11. Photograph of a photograph in possession of Rock Island ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photograph of a photograph in possession of Rock Island Arsenal Historical Office. BASEMENT, SHOWING ORIGINAL OPEN INTERIOR PLAN. DATED APRIL 7, 1942. - Rock Island Arsenal, Building No. 56, North Avenue & East Avenue, Rock Island, Rock Island County, IL

3. INTERIOR OF SOUTHEAST CORNER OF OPEN CONCOURSE, SHOWING WOODFRAMED ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. INTERIOR OF SOUTHEAST CORNER OF OPEN CONCOURSE, SHOWING WOOD-FRAMED WINDOWS AND CEMENTED TILE AND STEEL CEILING - Pennsylvania Railroad Station, Open Concourse & Concourse Roof Extension, 1101 Liberty Avenue, Pittsburgh, Allegheny County, PA

78 FR 5209 - 165th Meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-24

..., U.S. Department of Labor, 200 Constitution Avenue NW., Washington, DC 20210. The purpose of the open... Secretary, ERISA Advisory Council, U.S. Department of Labor, Suite N-5623, 200 Constitution Avenue NW...

75 FR 36677 - Notice of Relocation/Change of Address for the Bureau of Land Management, Office of Pipeline...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-28

... 4th Avenue, Suite 2, Anchorage, Alaska, is relocating to 188 West Northern Lights Boulevard, Suite 500... Pipeline Monitoring office at 411 West 4th Avenue, Suite 2, Anchorage, Alaska, will remain open during the...

LONGITUDINAL VIEW OF THE SOAKING PIT BUILDING INTERIOR WITH OPEN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LONGITUDINAL VIEW OF THE SOAKING PIT BUILDING INTERIOR WITH OPEN HEARTH IN BACKGROUND AND FURNACE PIT/ STACK AREA TO THE LEFT. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

75 FR 11199 - 150th Meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... Constitution Avenue, NW., Washington, DC 20210. The purpose of the open meeting, which will run from 1:30 p.m... Secretary, ERISA Advisory Council, U.S. Department of Labor, Suite N-5623, 200 Constitution Avenue, NW...

VIEW LOOKING WEST DOWN TRACKS WITH OPEN HEARTH ON THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW LOOKING WEST DOWN TRACKS WITH OPEN HEARTH ON THE RIGHT FOREGROUND AND BRICK POWER HOUSE TO LEFT, BLOOMING MILL IN BACKGROUND. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

Open Government Partnership as a Platform for Advancing Open Education Policy

ERIC Educational Resources Information Center

Gondol, Jan; Allen, Nicole

2015-01-01

An exciting new avenue for establishing and expanding national commitments to open education has emerged through the Open Government Partnership (OGP), a multilateral initiative that aims to secure commitments from governments to make their governance more open, accountable and responsive to citizens. In the past, there has not been a strong link…

4. VIEW LOOKING WEST FROM BASEMENT UNDER OPEN CONCOURSE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. VIEW LOOKING WEST FROM BASEMENT UNDER OPEN CONCOURSE - CEILING OF BRICK ARCHES; WOOD PANELS MARK LOCATION OF ORIGINAL GLASS PRISM SKYLIGHTS REPLACED WITH CONCRETE - Pennsylvania Railroad Station, Open Concourse & Concourse Roof Extension, 1101 Liberty Avenue, Pittsburgh, Allegheny County, PA

INTERIOR DETAIL, WINDOW OPENING ONTO THE SERVICE STAIR FROM DINING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR DETAIL, WINDOW OPENING ONTO THE SERVICE STAIR FROM DINING ROOM PASSAGE. OPENINGS LIKE THESE ARE PRESENT IN A NUMBER OF PLACES, “BORROWING LIGHT” FOR OTHERWISE DARK INTERIOR SPACES - The Woodlands, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

4. BASEMENT WALL BENEATH SOUTH PASSAGE SHOWING STEAM TUNNEL OPENING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. BASEMENT WALL BENEATH SOUTH PASSAGE SHOWING STEAM TUNNEL OPENING IN SOUTH WALL. - Pennsylvania Railroad Station, South Baggage Passage & Canopy, 1101 Liberty Avenue, Pittsburgh, Allegheny County, PA

DETAIL VIEW, SOUTH PORTICO, CENTER DOOR OPENING CONTAINING FRENCH WINDOWS. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW, SOUTH PORTICO, CENTER DOOR OPENING CONTAINING FRENCH WINDOWS. (NOTE THE INCISED STUCCO MIMICKING ASHLAR STONE COURSING - The Woodlands, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

77 FR 11116 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... Jersey Avenue NW., Washington, DC. STATUS: Open. MATTERS TO BE CONSIDERED: The Commission will consider and act upon the following in open session: Secretary of Labor v. Black Beauty Coal Co., Docket No...

13. SOUTH BEDROOM INTERIOR SHOWING OPEN DOOR TO WALKIN CLOSET ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. SOUTH BEDROOM INTERIOR SHOWING OPEN DOOR TO WALKIN CLOSET AT PHOTO CENTER, OPEN DOOR TO LIVING ROOM AT PHOTO RIGHT, AND OPEN DOOR TO BATHROOM AT PHOTO LEFT. VIEW TO NORTH. - Big Creek Hydroelectric System, Big Creek Town, Operator House, Orchard Avenue south of Huntington Lake Road, Big Creek, Fresno County, CA

75 FR 60457 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

... EXPORT-IMPORT BANK OF THE UNITED STATES Sunshine Act Meeting ACTION: Notice of a Partially Open... Avenue, NW., Washington, DC 20571. Open Agenda Item: PEFCO Secured Note Issues Resolutions. Public Participation: The meeting will be open to public participation for Item No. 1 only. Further Information: For...

Internal pedestrian circulation and common open space, also illustrating mature ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Internal pedestrian circulation and common open space, also illustrating mature landscape features. Building 35 at left foreground. Facing east - Harbor Hills Housing Project, 26607 Western Avenue, Lomita, Los Angeles County, CA

33 CFR 117.543 - Bear Creek.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Parkway Bridge, mile 2.1, between Dundalk and Sparrows Point, shall open on signal; except that, from... bridge, mile 3.4 at Wise Avenue between Dundalk and Sparrows Point, shall open on signal if at least four...

33 CFR 117.543 - Bear Creek.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Parkway Bridge, mile 2.1, between Dundalk and Sparrows Point, shall open on signal; except that, from... bridge, mile 3.4 at Wise Avenue between Dundalk and Sparrows Point, shall open on signal if at least four...

33 CFR 117.543 - Bear Creek.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., mile 2.1, both between Dundalk and Sparrows Point, shall open on signal; except that, from April 16... 3.4 at Wise Avenue between Dundalk and Sparrows Point, shall open on signal if at least four hours...

33 CFR 117.543 - Bear Creek.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., mile 2.1, both between Dundalk and Sparrows Point, shall open on signal; except that, from April 16... 3.4 at Wise Avenue between Dundalk and Sparrows Point, shall open on signal if at least four hours...

33 CFR 117.543 - Bear Creek.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Parkway Bridge, mile 2.1, between Dundalk and Sparrows Point, shall open on signal; except that, from... bridge, mile 3.4 at Wise Avenue between Dundalk and Sparrows Point, shall open on signal if at least four...

75 FR 47026 - Cedar Creek and Belle Grove National Historical Park Advisory Commission; Notice of Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-04

.... Location: Warren County Government Center, 220 North Commerce Avenue, Front Royal, VA. Date: December 16... 16, 2011 Location: Warren County Government Center, 220 North Commerce Avenue, Front Royal, VA. All meetings will convene at 8:30 a.m. and are open to the public. FOR FURTHER INFORMATION CONTACT: Diann Jacox...

15. NORTH BEDROOM INTERIOR SHOWING OPEN DOOR TO WALKIN CLOSET ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. NORTH BEDROOM INTERIOR SHOWING OPEN DOOR TO WALKIN CLOSET AT PHOTO RIGHT, AND OPEN DOOR TO LIVING ROOM AT PHOTO LEFT. VIEW TO EAST. - Big Creek Hydroelectric System, Big Creek Town, Operator House, Orchard Avenue south of Huntington Lake Road, Big Creek, Fresno County, CA

The Role of Advanced High School Coursework in Increasing STEM Career Interest

ERIC Educational Resources Information Center

Sadler, Philip M.; Sonnert, Gerhard; Hazari, Zahra; Tai, Robert

2014-01-01

Several avenues are open to students who wish to study advanced science or mathematics in high school, which include Advanced Placement courses and teacher-designed courses unaffiliated with organized programs. We employ a retrospective cohort study of 4,691 nationally representative college students at 34 randomly selected, colleges and…

Environmental Factors of Distance Learning: An Exploratory Study

ERIC Educational Resources Information Center

Klaus, Tim; Changchit, Chuleeporn

2014-01-01

The widespread use of the Internet has opened new avenues for learning in higher education. Distance education through the Internet has had a large increase over the last decade. This study focuses on examining factors of the online course environment that affect student satisfaction. The results identify factors that affect students' satisfaction…

Literature Especially with Remedial Readers (Open to Suggestion).

ERIC Educational Resources Information Center

Glowacki, Joan

1990-01-01

Argues that incorporating literature into daily reading instruction opens up avenues that junior high remedial students may never think exist for them. Presents eight techniques to help teachers get started using literature in the remedial classroom. (RS)

DETAIL VIEW, WINDOW BOW IN EAST WALL. (NOTE THE OPENING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW, WINDOW BOW IN EAST WALL. (NOTE THE OPENING FOR THE CRYPTOPORTICUS TO THE BOW’S RIGHT. THIS EXTERIOR FEATURE EXTENDS BENEATH THE NORTH TERRACE - The Woodlands, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

West end view, "Boat Shop" open doorway, Facility 7 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

West end view, "Boat Shop" - open doorway, Facility 7 connected on the left, view facing east-southeast - U.S. Naval Base, Pearl Harbor, Boat Shop, Seventh Street near Avenue E, Pearl City, Honolulu County, HI

Researchers uncover cause of genetic anomaly linked to cancer | Center for Cancer Research

Cancer.gov

In a new study in Nature, Shiv Grewal’s team has identified a process that drives a genetic anomaly linked to cancer and other diseases. This work could open new avenues for treatment of cancer and other human diseases. Learn more...

Iron Isotopes in Spherical Hematite and Goethite Concretions from the Navajo Sandstone (Utah, USA): A Prospective Study for "Martian Blueberries"

NASA Astrophysics Data System (ADS)

Busigny, V.; Dauphas, N.

2006-03-01

Iron isotopes of terrestrial hematite and goethite concretions provide clues on fluid transport, reservoir sizes, redox variations and biotic versus abiotic processes. This opens several avenues of research for future work on Martian blueberries.

View of main hoist wire rope drum and brakes, open ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of main hoist wire rope drum and brakes, open contact boards are in view at the far right wall - Puget Sound Naval Shipyard, Portal Gantry Crane No. 42, Pier 5, Farragut Avenue, Bremerton, Kitsap County, WA

75 FR 4557 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-28

... Open Meeting of the Board of Directors of the Export-Import Bank of the United States. Time and Place... Avenue, NW., Washington, DC 20571. Open Agenda Items Item No. 1: Ex-Im Bank Advisory Committee (16th... Participation: The meeting will be open to public observation for Items No. 1 & 2 only. FOR FURTHER INFORMATION...

Play and Literacy in Early Childhood: Research from Multiple Perspectives.

ERIC Educational Resources Information Center

Roskos, Kathleen A., Ed.; Christie, James F., Ed.

Noting that an examination of play from diverse perspectives deepens understanding and opens up new avenues for research and educational practice, this book brings together studies, research syntheses, and critical commentaries that examine play-literacy relationships from cognitive, ecological, and cultural perspectives. Each set of chapters is…

33 CFR 117.181 - Oakland Inner Harbor Tidal Canal.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Tidal Canal. The draws of the Alameda County highway drawbridges at Park Street, mile 5.2; Fruitvale Avenue, mile 5.6; and High Street, mile 6.0; and the U.S. Army Corps of Engineers railroad drawbridge, mile 5.6 at Fruitvale Avenue, shall open on signal; except that, from 8 a.m. to 9 a.m. and 4:30 p.m. to...

33 CFR 117.181 - Oakland Inner Harbor Tidal Canal.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Tidal Canal. The draws of the Alameda County highway drawbridges at Park Street, mile 5.2; Fruitvale Avenue, mile 5.6; and High Street, mile 6.0; and the U.S. Army Corps of Engineers railroad drawbridge, mile 5.6 at Fruitvale Avenue, shall open on signal; except that, from 8 a.m. to 9 a.m. and 4:30 p.m. to...

GENERAL VIEW OF WESTERN PART OF PLANT INCLUDING (LEFT TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF WESTERN PART OF PLANT INCLUDING (LEFT TO RIGHT) BETHLEHEM RAIL MILL, GENERAL OFFICE BUILDING, MACHINE SHOP, BAR MILL, BLOOMING MILL & OPEN HEARTH PLANT. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

33 CFR 117.793 - Hutchinson River (Eastchester Creek).

Code of Federal Regulations, 2011 CFR

2011-07-01

... open on signal. (b) The draw of the Hutchinson River Parkway Bridge, mile 0.9, at the Bronx, New York shall open on signal if at least a two-hour notice is given to the New York City Department of... Avenue Bridge, mile 2.9, shall open on signal from three hours before to three hours after the predicted...

33 CFR 117.793 - Hutchinson River (Eastchester Creek).

Code of Federal Regulations, 2010 CFR

2010-07-01

... open on signal. (b) The draw of the Hutchinson River Parkway Bridge, mile 0.9, at the Bronx, New York shall open on signal if at least a two-hour notice is given to the New York City Department of... Avenue Bridge, mile 2.9, shall open on signal from three hours before to three hours after the predicted...

33 CFR 117.793 - Hutchinson River (Eastchester Creek).

Code of Federal Regulations, 2013 CFR

2013-07-01

... open on signal. (b) The draw of the Hutchinson River Parkway Bridge, mile 0.9, at the Bronx, New York shall open on signal if at least a two-hour notice is given to the New York City Department of... Avenue Bridge, mile 2.9, shall open on signal from three hours before to three hours after the predicted...

33 CFR 117.793 - Hutchinson River (Eastchester Creek).

Code of Federal Regulations, 2014 CFR

2014-07-01

... open on signal. (b) The draw of the Hutchinson River Parkway Bridge, mile 0.9, at the Bronx, New York shall open on signal if at least a two-hour notice is given to the New York City Department of... Avenue Bridge, mile 2.9, shall open on signal from three hours before to three hours after the predicted...

33 CFR 117.793 - Hutchinson River (Eastchester Creek).

Code of Federal Regulations, 2012 CFR

2012-07-01

... open on signal. (b) The draw of the Hutchinson River Parkway Bridge, mile 0.9, at the Bronx, New York shall open on signal if at least a two-hour notice is given to the New York City Department of... Avenue Bridge, mile 2.9, shall open on signal from three hours before to three hours after the predicted...

11. LIVING ROOM INTERIOR SHOWING BUILTIN CUPBOARD AND OPEN DOOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. LIVING ROOM INTERIOR SHOWING BUILT-IN CUPBOARD AND OPEN DOOR TO KITCHEN ON THE NORTH WALL AT PHOTO CENTER. OPEN DOOR ON WEST WALL AT PHOTO LEFT ENTERS NORTH BEDROOM. VIEW TO NORTH. - Big Creek Hydroelectric System, Big Creek Town, Operator House, Orchard Avenue south of Huntington Lake Road, Big Creek, Fresno County, CA

VIEW OF SEMIDISMANTLED HOPPER CAR ON THE ORE TRESTLE FACING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF SEMI-DISMANTLED HOPPER CAR ON THE ORE TRESTLE FACING NORTHWEST WITH OPEN HEARTH BUILDING IN THE BACKGROUND AND THE INGOT MOLD CONDITIONING BUILDING TO THE RIGHT. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

78 FR 69657 - Secretary of Energy Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... DEPARTMENT OF ENERGY Secretary of Energy Advisory Board AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Secretary of Energy..., Designated Federal Officer, U.S. Department of Energy, 1000 Independence Avenue SW., Washington, DC 20585...

76 FR 60011 - Secretary of Energy Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... DEPARTMENT OF ENERGY Secretary of Energy Advisory Board AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Secretary of Energy.... Department of Energy, 1000 Independence Avenue, SW., Washington, DC 20585; telephone (202) 586-0383 or...

Nanotechnology applications in the forest products industry

Treesearch

Robert J. Moon; Charles R. Frihart; Theodore Wegner

2006-01-01

Nanotechnology is the study and engineering of matter at the dimensions of 1 to 100 nanometers, where the physical, chemical, or biological properties are fundamentally different from those of the bulk material. By expanding our understanding and control of matter at such levels, new avenues in product development can be opened. Nanoscale-based science has...

Narrative Counseling in Schools: Powerful & Brief

ERIC Educational Resources Information Center

Winslade, John M.; Monk, Gerald D.

2006-01-01

Narrative counseling is based on the premise that stories, rather than hard-nosed realities, shape our lives. By changing the stories that negatively label and define students, they are helped to open up new avenues and opportunities. In this second edition of their best-selling book, the authors present even more case studies, guidance, and…

New Regions of the Human Genome Linked to Skin Color Variation in Some African Populations

Cancer.gov

In the first study of its kind, an international team of genomics researchers has identified new regions of the human genome that are associated with skin color variation in some African populations, opening new avenues for research on skin diseases and cancer in all populations.

Recognition, Accreditation and Validation of Non-Formal and Informal Learning: Prospects for Lifelong Learning in Nepal

ERIC Educational Resources Information Center

Regmi, Kapil Dev

2009-01-01

This study was an exploration on the various issues related to recognition, accreditation and validation of non-formal and informal learning to open up avenues for lifelong learning and continuing education in Nepal. The perceptions, experiences, and opinions of Nepalese Development Activists, Educational Administrators, Policy Actors and…

Developing EZH2-Targeted Therapy for Lung Cancer | Office of Cancer Genomics

Cancer.gov

Epigenetic targets are exciting new avenues for cancer drug discovery. Zhang and colleagues have designed the open-source EZH2 inhibitor JQEZ5 and shown antitumor efficacy in vitro and in vivo in preclinical studies in murine and human lung adenocarcinoma models expressing high levels of EZH2.

General Strain Theory, Peer Rejection, and Delinquency/Crime

ERIC Educational Resources Information Center

Higgins, George E.; Piquero, Nicole L.; Piquero, Alex R.

2011-01-01

The development of general strain theory (GST) has led to a renewed focus on the influence of negative life experiences on antisocial behavior. Although a number of studies have generated an impressive array of support for the theory, several avenues remain open for research. In this article, we examine how a specific noxious stimuli, peer…

Improvisation and Meditation in the Academy: Parallel Ordeals, Insights, and Openings

ERIC Educational Resources Information Center

Sarath, Edward

2015-01-01

This article examines parallel challenges and avenues for progress I have observed in my efforts to introduce improvisation in classical music studies, and meditation in music and overall academic settings. Though both processes were once central in their respective knowledge traditions--improvisation in earlier eras of European classical music,…

Hydraulic modeling of stream channels and structures in Harbor and Crow Hollow Brooks, Meriden, Connecticut

USGS Publications Warehouse

Weiss, Lawrence A.; Sears, Michael P.; Cervione, Michael A.

1994-01-01

Effects of urbanization have increased the frequency and size of floods along certain reaches of Harbor Brook and Crow Hollow Brook in Meriden, Conn. A floodprofile-modeling study was conducted to model the effects of selected channel and structural modifications on flood elevations and inundated areas. The study covered the reach of Harbor Brook downstream from Interstate 691 and the reach of Crow Hollow Brook downstream from Johnson Avenue. Proposed modifications, which include changes to bank heights, channel geometry, structural geometry, and streambed armoring on Harbor Brook and changes to bank heights on Crow Hollow Brook, significantly lower flood elevations. Results of the modeling indicate a significant reduction of flood elevations for the 10-year, 25-year, 35-year, 50-year, and 100-year flood frequencies using proposed modifications to (1 ) bank heights between Harbor Brook Towers and Interstate 691 on Harbor Brook, and between Centennial Avenue and Johnson Avenue on Crow Hollow Brook; (2) channel geometry between Coe Avenue and Interstate 69 1 on Harbor Brook; (3) bridge and culvert opening geometry between Harbor Brook Towers and Interstate 691 on Harbor Brook; and (4) channel streambed armoring between Harbor Brook Towers and Interstate 691 on Harbor Brook. The proposed modifications were developed without consideration of cost-benefit ratios.

75 FR 53684 - Secretary of Energy Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... DEPARTMENT OF ENERGY Secretary of Energy Advisory Board AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Secretary of Energy..., September 16, 2010. 8:30 a.m.-4 p.m. ADDRESSES: Department of Energy, 1000 Independence Avenue, SW...

1. EAST AND SOUTH SIDES OF STATION, SHOWING (LEFT BACKGROUND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. EAST AND SOUTH SIDES OF STATION, SHOWING (LEFT BACKGROUND TO CENTER FOREGROUND) SOUTH CANOPY, OPEN CONCOURSE ROOF, AND CONCOURSE ROOF EXTENSION (SMALL BUILDING UNDER CONCOURSE ROOF IS TEMPORARY AMTRAK STATION) - Pennsylvania Railroad Station, Open Concourse & Concourse Roof Extension, 1101 Liberty Avenue, Pittsburgh, Allegheny County, PA

INTERIOR DETAIL, SOUTHEAST CABINET NORTH WALL. THE DOORS TO THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR DETAIL, SOUTHEAST CABINET NORTH WALL. THE DOORS TO THE LEFT OF THE CHIMNEY MASS OPEN ONTO CLOSETS. ON THE RIGHT, THERE ARE TWO CLOSETS WITH JIB DOORS WITHIN THE CHIMNEY MASS. THE OPEN DOOR CONNECTS WITH THE DRAWING ROOM - The Woodlands, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

75 FR 42446 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-21

... MORE INFORMATION: Mitch Katz, Office of Public Affairs, (202) 326-2180. Recorded Message: (202) 326... Pennsylvania Avenue, NW., Washington, DC 20580. STATUS: Part of this meeting will be open to the public. The rest of the meeting will be closed to the public. Matters To Be Considered Portion Open to the Public...

76 FR 38647 - Secretary of Energy Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

... DEPARTMENT OF ENERGY Secretary of Energy Advisory Board AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Secretary of Energy..., July 20, 2011 8 a.m.-5 p.m. ADDRESSES: U.S. Department of Energy, 1000 Independence Avenue, SW...

78 FR 52911 - Secretary of Energy Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... DEPARTMENT OF ENERGY Secretary of Energy Advisory Board AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Secretary of Energy..., September 13, 2013, 9:00 a.m.-2:00 p.m. ADDRESSES: Department of Energy, 1000 Independence Avenue SW...

On the hunt for elusive ``meanings''

NASA Astrophysics Data System (ADS)

Roth, Wolff-Michael

2012-09-01

The feature article discussed in this forum presents an interesting description of how students work in the context of a virtual world, where they design phenomena that they subsequently investigate by analyzing graphical representations. The study is aligned with the current canon of science education interested in understanding the inter-psychological and intra-psychological determinants of learning. Its main focus is on "meaning making." In this contribution to the forum, I articulate some shortcomings inherent in this theoretical notion, which, in essence, hides rather than reveals the real issues in and of learning. I offer some alternative avenues, both theoretical and methodological, for framing pertinent issues; in so doing, I (endeavor to) open up new avenues for research in science education. In essence, therefore, I offer possible avenues in response to the question, "What more can there be done by science education research?" that would allow us to eschew what I perceive to be hidden contradictions that interfere with making theoretical and practical advances in our field.

33 CFR 117.505 - Terrebonne Bayou.

Code of Federal Regulations, 2012 CFR

2012-07-01

... open on signal; except that from 9 p.m. to 5 a.m. the draws shall open on signal if at least four hours..., from 5 p.m. to 9 a.m. the draw shall open on signal if at least four hours notice is given. (c) The draws of the Howard Avenue bridge, mile 35.0, and the Daigleville bridge, mile 35.5, at Houma, shall...

33 CFR 117.505 - Terrebonne Bayou.

Code of Federal Regulations, 2013 CFR

2013-07-01

... open on signal; except that from 9 p.m. to 5 a.m. the draws shall open on signal if at least four hours..., from 5 p.m. to 9 a.m. the draw shall open on signal if at least four hours notice is given. (c) The draws of the Howard Avenue bridge, mile 35.0, and the Daigleville bridge, mile 35.5, at Houma, shall...

33 CFR 117.505 - Terrebonne Bayou.

Code of Federal Regulations, 2011 CFR

2011-07-01

... open on signal; except that from 9 p.m. to 5 a.m. the draws shall open on signal if at least four hours..., from 5 p.m. to 9 a.m. the draw shall open on signal if at least four hours notice is given. (c) The draws of the Howard Avenue bridge, mile 35.0, and the Daigleville bridge, mile 35.5, at Houma, shall...

33 CFR 117.505 - Terrebonne Bayou.

Code of Federal Regulations, 2014 CFR

2014-07-01

... open on signal; except that from 9 p.m. to 5 a.m. the draws shall open on signal if at least four hours...; except that, from 5 p.m. to 9 a.m. the draw shall open on signal if at least four hours notice is given. (d) The draws of the Howard Avenue bridge, mile 35.0, and the Daigleville bridge, mile 35.5, at Houma...

76 FR 17461 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-29

... a.m. PLACE: Commission hearing room, 901 New York Avenue, NW., Suite 200, Washington, DC 20268-0001. STATUS: Part of this meeting will be open to the public. The rest of the meeting will be closed to the public. The open part of the meeting will be audiocast. The audiocast can be accessed via the Commission...

76 FR 38222 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

... a.m. PLACE: Commission hearing room, 901 New York Avenue, NW., Suite 200, Washington, DC 20268-0001. STATUS: Part of this meeting will be open to the public. The rest of the meeting will be closed to the public. The open part of the meeting will be audiocast. The audiocast can be accessed via the Commission...

76 FR 18829 - Open Meeting of the President's Advisory Council on Financial Capability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-05

... DEPARTMENT OF THE TREASURY Open Meeting of the President's Advisory Council on Financial... Council on Financial Capability (``Council'') will convene its second meeting on April 21, 2011 at the Department of Education, 400 Maryland Avenue, SW., Washington, DC, beginning at 11:00 a.m. Eastern Time. The...

INTERIOR VIEW, WESTERN STOREROOM LOOKING WEST. THE OPENING TO THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR VIEW, WESTERN STOREROOM LOOKING WEST. THE OPENING TO THE LEFT OF THE RELIEVING ARCH CONNECTS TO A CORRIDOR LEADING TO THE OFFICE. THE CANTED WALL OF THIS CORRIDOR MARKS THE INTERIOR OF ONE OF THE THREE-SIDED WINDOW BAYS OF THE ORIGINAL HOUSE - The Woodlands, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

23. View of open firststory passageway of Andrew McLean Company ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. View of open first-story passageway of Andrew McLean Company Textile Mill Building No. 1, looking west - Dundee Canal Industrial Historic District, Beginning at George Street in Passaic & extending north along Dundee Canal approximately 1.2 miles to Canal headgates opposite East Clifton Avenue in Clifton, Passaic, Passaic County, NJ

77 FR 3774 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

.... CONTACT PERSON FOR MORE INFORMATION: Mitch Katz, Office of Public Affairs (202) 326-2180. Recorded Message... Pennsylvania Avenue NW., Washington, DC 20580. STATUS: Part of this meeting will be open to the public. The rest of the meeting will be closed to the public. Matters To Be Considered Portion Open to the Public...

78 FR 55696 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-11

... EXPORT-IMPORT BANK Sunshine Act Meeting ACTION: Notice of a Partially Open Meeting of the Board of...:00 p.m. The meeting will be held at Ex-Im Bank in Room 321, 811 Vermont Avenue NW., Washington, DC...: The meeting will be open to public observation for Item No. 1 only. FURTHER INFORMATION: Members of...

18. BATHROOM INTERIOR SHOWING OPEN DOOR TO SOUTH BEDROOM AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. BATHROOM INTERIOR SHOWING OPEN DOOR TO SOUTH BEDROOM AT PHOTO CENTER, TOILET AT EXTREME PHOTO RIGHT BOTTOM, OPEN DOOR TO MEDICINE CABINET AT PHOTO RIGHT. A WALLPAPER WAINSCOT COVERS THE LOWER PORTION OF THE ORIGINAL FIBERBOARD WALL COVERING. THE FLOOR IS LINOLEUM. VIEW TO SOUTHEAST. - Big Creek Hydroelectric System, Big Creek Town, Operator House, Orchard Avenue south of Huntington Lake Road, Big Creek, Fresno County, CA

17. BATHROOM INTERIOR SHOWING OPEN DOOR TO NORTH BEDROOM AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. BATHROOM INTERIOR SHOWING OPEN DOOR TO NORTH BEDROOM AT PHOTO RIGHT, PLUMBING FOR SINK IN CORNER AT PHOTO CENTER, AND 1 OVER 1 LIGHT DOUBLE-HUNG, WOODFRAME WINDOW AT PHOTO LEFT. VIEW TO NORTHWEST. - Big Creek Hydroelectric System, Big Creek Town, Operator House, Orchard Avenue south of Huntington Lake Road, Big Creek, Fresno County, CA

View looking south out the door opening from the south ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View looking south out the door opening from the south side of the rotunda extension onto the "dog house" or vestibule positioned where the west Verandah of the south wing turns ninety degrees and continues along the south wall of the central pavilion. - U. S. Naval Asylum, Biddle Hall, Gray's Ferry Avenue, Philadelphia, Philadelphia County, PA

Control relaxation via dephasing: A quantum-state-diffusion study

NASA Astrophysics Data System (ADS)

Jing, Jun; Yu, Ting; Lam, Chi-Hang; You, J. Q.; Wu, Lian-Ao

2018-01-01

Dynamical decoupling as a quantum control strategy aims at suppressing quantum decoherence adopting the popular philosophy that the disorder in the unitary evolution of the open quantum system caused by environmental noises should be neutralized by a sequence of ordered or well-designed external operations acting on the system. This work studies the solution of quantum-state-diffusion equations by mixing two channels of environmental noises, i.e., relaxation (dissipation) and dephasing. It is interesting to find in two-level and three-level atomic systems that a non-Markovian relaxation or dissipation process can be suppressed by a Markovian dephasing noise. The discovery results in an anomalous control strategy by coordinating relaxation and dephasing processes. Our approach opens an avenue of noise control strategy with no artificial manipulation over the open quantum systems.

Interior, second floor south side of building toward east end ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior, second floor south side of building toward east end - Fitzsimons General Hospital, Open Air Tuberculosis Ward, West Pennington Avenue & North Hickey Street Southwest Corner, Aurora, Adams County, CO

Interior, second floor north side of building toward east end ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior, second floor north side of building toward east end - Fitzsimons General Hospital, Open Air Tuberculosis Ward, West Pennington Avenue & North Hickey Street Southwest Corner, Aurora, Adams County, CO

33 CFR 117.611 - Neponset River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Massachusetts § 117.611 Neponset River. The Granite... of the Granite Avenue Bridge shall open on signal from May 1 through October 31; 6 a.m. to 12...

33 CFR 117.611 - Neponset River.

Code of Federal Regulations, 2013 CFR

2013-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Massachusetts § 117.611 Neponset River. The Granite... of the Granite Avenue Bridge shall open on signal from May 1 through October 31; 6 a.m. to 12...

33 CFR 117.611 - Neponset River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Massachusetts § 117.611 Neponset River. The Granite... of the Granite Avenue Bridge shall open on signal from May 1 through October 31; 6 a.m. to 12...

33 CFR 117.611 - Neponset River.

Code of Federal Regulations, 2012 CFR

2012-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Massachusetts § 117.611 Neponset River. The Granite... of the Granite Avenue Bridge shall open on signal from May 1 through October 31; 6 a.m. to 12...

33 CFR 117.611 - Neponset River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Massachusetts § 117.611 Neponset River. The Granite... of the Granite Avenue Bridge shall open on signal from May 1 through October 31; 6 a.m. to 12...

39 CFR 3004.12 - Reading room.

Code of Federal Regulations, 2010 CFR

2010-07-01

... reading room at its offices is open during business hours. (b) The records available for public inspection... Reading room. (a) The Commission maintains a public reading room at its offices (901 New York Avenue, NW...

VIEW FROM CHARGING FLOOR LOOKING EAST AT COAL HOPPER, AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW FROM CHARGING FLOOR LOOKING EAST AT COAL HOPPER, AND PHYSICAL REMAINS OF GAS PRODUCER SYSTEM. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

N-Heterocyclic molecule-capped gold nanoparticles as effective antibiotics against multi-drug resistant bacteria

NASA Astrophysics Data System (ADS)

Feng, Yan; Chen, Wenwen; Jia, Yuexiao; Tian, Yue; Zhao, Yuyun; Long, Fei; Rui, Yukui; Jiang, Xingyu

2016-07-01

We demonstrate that N-heterocyclic molecule-capped gold nanoparticles (Au NPs) have broad-spectrum antibacterial activity. Optimized antibacterial activity can be achieved by using different initial molar ratios (1 : 1 and 10 : 1) of N-heterocyclic prodrugs and the precursor of Au NPs (HAuCl4). This work opens up new avenues for antibiotics based on Au NPs.We demonstrate that N-heterocyclic molecule-capped gold nanoparticles (Au NPs) have broad-spectrum antibacterial activity. Optimized antibacterial activity can be achieved by using different initial molar ratios (1 : 1 and 10 : 1) of N-heterocyclic prodrugs and the precursor of Au NPs (HAuCl4). This work opens up new avenues for antibiotics based on Au NPs. Electronic supplementary information (ESI) available. See DOI: 10.1039/c6nr03317b

16. NORTH BEDROOM INTERIOR SHOWING OPEN DOOR TO BATHROOM AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. NORTH BEDROOM INTERIOR SHOWING OPEN DOOR TO BATHROOM AT PHOTO LEFT, TWO 1 OVER 1 LIGHT DOUBLEHUNG, WOODFRAME WINDOWS IN A PAIRED ARRANGEMENT AT PHOTO CENTER, AND THE CLOSED DOOR TO THE KITCHEN AT PHOTO RIGHT. VIEW TO WEST. - Big Creek Hydroelectric System, Big Creek Town, Operator House, Orchard Avenue south of Huntington Lake Road, Big Creek, Fresno County, CA

122. View in subway showing air filters for unit turbinegenerator ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

122. View in subway showing air filters for unit turbine-generator unit no. 3; looking north. To the left is opening through wall which brings fresh air into the filters; this opening is above the tailrace. Photo by Jet Lowe, HAER, 1989. - Puget Sound Power & Light Company, White River Hydroelectric Project, 600 North River Avenue, Dieringer, Pierce County, WA

33 CFR 117.558 - Curtis Creek.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Avenue Bridge, mile 0.9 at Baltimore shall operate as follows: (1) Need not open from 6 a.m. on February 17, 2011 to 11:59 p.m. on January 20, 2011; except, vessel openings shall be provided on signal if at... p.m. on January 20, 2011 to 11:59 p.m. on February 12, 2011. The opposite connecting spans on the...

10. View (looking west) of the ground floor in the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. View (looking west) of the ground floor in the south segment of the building. The door opening is on the Central Avenue sidewalk. The ground floor had two noteworthy pressed-steel ceilings, an elaborate one in the larger west room and a plain one in the smaller 'back room.' Most of the elaborate ceiling panels were removed when a suspended ceiling (here removed) was installed. The plain ceiling is still in-tact above the suspended ceiling. Credit GADA/MRM. - Stroud Building, 31-33 North Central Avenue, Phoenix, Maricopa County, AZ

Low Dimensional Carbon Materials for Nanooptics and Nanoplasmonics

DTIC Science & Technology

2015-12-11

structure of the 2D glass supported by a graphene window and identified it as a bi-tetrahedral layer of SiO2 only 3 atoms thick. Our atomic resolution...developed can be directly applied to study other 2D materials such as molybdenum disulfide and 2D glasses . Novel properties in these materials open...up new avenues for studying old and new physics including glass phase transition and valley Hall effect. 15. SUBJECT TERMS graphene, bilayer graphene

Interior, first floor southeast side of building, showing french doors ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior, first floor southeast side of building, showing french doors and interior windows - Fitzsimons General Hospital, Open Air Tuberculosis Ward, West Pennington Avenue & North Hickey Street Southwest Corner, Aurora, Adams County, CO

Interior of the second floor dance hall showing tall and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior of the second floor dance hall showing tall and narrow window openings with 10-foot scale near center, looking south. - Bower Building, 409-413 East Weber Avenue, Stockton, San Joaquin County, CA

33 CFR 117.1087 - Fox River.

Code of Federal Regulations, 2012 CFR

2012-07-01

... OPERATION REGULATIONS Specific Requirements Wisconsin § 117.1087 Fox River. (a) The draws of the Canadian..., Wisconsin Street bridge, mile 57.0, and the Congress Avenue bridge, mile 58.3 all at Oshkosh, shall open on...

33 CFR 117.1087 - Fox River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... OPERATION REGULATIONS Specific Requirements Wisconsin § 117.1087 Fox River. (a) The draws of the Canadian..., Wisconsin Street bridge, mile 57.0, and the Congress Avenue bridge, mile 58.3 all at Oshkosh, shall open on...

33 CFR 117.1087 - Fox River.

Code of Federal Regulations, 2013 CFR

2013-07-01

... OPERATION REGULATIONS Specific Requirements Wisconsin § 117.1087 Fox River. (a) The draws of the Canadian..., Wisconsin Street bridge, mile 57.0, and the Congress Avenue bridge, mile 58.3 all at Oshkosh, shall open on...

33 CFR 117.1087 - Fox River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... OPERATION REGULATIONS Specific Requirements Wisconsin § 117.1087 Fox River. (a) The draws of the Canadian..., Wisconsin Street bridge, mile 57.0, and the Congress Avenue bridge, mile 58.3 all at Oshkosh, shall open on...

33 CFR 117.1087 - Fox River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... OPERATION REGULATIONS Specific Requirements Wisconsin § 117.1087 Fox River. (a) The draws of the Canadian..., Wisconsin Street bridge, mile 57.0, and the Congress Avenue bridge, mile 58.3 all at Oshkosh, shall open on...

High-speed homogenization coupled with microwave-assisted extraction followed by liquid chromatography-tandem mass spectrometry for the direct determination of alkaloids and flavonoids in fresh Isatis tinctoria L. hairy root cultures.

PubMed

Jiao, Jiao; Gai, Qing-Yan; Zhang, Lin; Wang, Wei; Luo, Meng; Zu, Yuan-Gang; Fu, Yu-Jie

2015-06-01

A new, simple and efficient analysis method for fresh plant in vitro cultures-namely, high-speed homogenization coupled with microwave-assisted extraction (HSH-MAE) followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS)-was developed for simultaneous determination of six alkaloids and eight flavonoids in Isatis tinctoria hairy root cultures (ITHRCs). Compared with traditional methods, the proposed HSH-MAE offers the advantages of easy manipulation, higher efficiency, energy saving, and reduced waste. Cytohistological studies were conducted to clarify the mechanism of HSH-MAE at cellular/tissue levels. Moreover, the established LC-MS/MS method showed excellent linearity, precision, repeatability, and reproducibility. The HSH-MAE-LC-MS/MS method was also successfully applied for screening high-productivity ITHRCs. Overall, this study opened up a new avenue for the direct determination of secondary metabolic profiles from fresh plant in vitro cultures, which is valuable for improving quality control of plant cell/organ cultures and sheds light on the metabolomic analysis of biological samples. Graphical Abstract HSH-MAE-LC-MS/MS opened up a new avenue for the direct determination of alkaloids and flavonoids in fresh Isatis tinctoria hairy root cultures.

77 FR 12235 - Meeting of the National Advisory Council on Innovation and Entrepreneurship

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... Entrepreneurship will hold a meeting on Tuesday, March 13, 2012. The open meeting will be conducted from 10 a.m.-1 p.m. and will be open to the public. The meeting will take place at Gallier Hall, 545 St. Charles.... Time: 10 a.m.-1 p.m. (CST). ADDRESSES: Gallier Hall, 545 St. Charles Avenue, New Orleans, LA 70130...

One of the larger open spaces on the third floor. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

One of the larger open spaces on the third floor. This space was used most often for drafting work and for general experimentation. Physical evidence on the ceiling indicates existence of partition walls for smaller rooms, but no photographic or documentary evidence has surfaced to verify this. - Thomas A. Edison Laboratories, Building No. 5, Main Street & Lakeside Avenue, West Orange, Essex County, NJ

William L. Baker: Fire ecology in Rocky Mountain landscapes [book review

Treesearch

Daniel Yaussy

2010-01-01

Every so often, we need something to make us question our beliefs and views of the natural order of things, to open our minds to different versions of reality so that we become better informed and open to new avenues of thought. The author comes across as slightly antagonistic in his attempt to set the record straight concerning fires in the Rocky Mountains.

33 CFR 117.313 - New River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Avenue bridge, mile 1.4 at Fort Lauderdale shall open on signal; except that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays, the draw need not open... that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays...

33 CFR 117.313 - New River.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Avenue bridge, mile 1.4 at Fort Lauderdale shall open on signal; except that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays, the draw need not open... that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays...

33 CFR 117.313 - New River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Avenue bridge, mile 1.4 at Fort Lauderdale shall open on signal; except that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays, the draw need not open... that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays...

33 CFR 117.313 - New River.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Avenue bridge, mile 1.4 at Fort Lauderdale shall open on signal; except that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays, the draw need not open... that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays...

33 CFR 117.313 - New River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Avenue bridge, mile 1.4 at Fort Lauderdale shall open on signal; except that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays, the draw need not open... that, from 7:30 a.m. to 9 a.m. and 4:30 p.m. to 6 p.m., Monday through Friday, except Federal holidays...

Nonlinear Metasurface for Simultaneous Control of Spin and Orbital Angular Momentum in Second Harmonic Generation.

PubMed

Li, Guixin; Wu, Lin; Li, King F; Chen, Shumei; Schlickriede, Christian; Xu, Zhengji; Huang, Siya; Li, Wendi; Liu, Yanjun; Pun, Edwin Y B; Zentgraf, Thomas; Cheah, Kok W; Luo, Yu; Zhang, Shuang

2017-12-13

The spin and orbital angular momentum (SAM and OAM) of light is providing a new gateway toward high capacity and robust optical communications. While the generation of light with angular momentum is well studied in linear optics, its further integration into nonlinear optical devices will open new avenues for increasing the capacity of optical communications through additional information channels at new frequencies. However, it has been challenging to manipulate the both SAM and OAM of nonlinear signals in harmonic generation processes with conventional nonlinear materials. Here, we report the generation of spin-controlled OAM of light in harmonic generations by using ultrathin photonic metasurfaces. The spin manipulation of OAM mode of harmonic waves is experimentally verified by using second harmonic generation (SHG) from gold meta-atom with 3-fold rotational symmetry. By introducing nonlinear phase singularity into the metasurface devices, we successfully generate and measure the topological charges of spin-controlled OAM mode of SHG through an on-chip metasurface interferometer. The nonlinear photonic metasurface proposed in this work not only opens new avenues for manipulating the OAM of nonlinear optical signals but also benefits the understanding of the nonlinear spin-orbit interaction of light in nanoscale devices.

33 CFR 117.655 - Thunder Bay River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Second Avenue bridge, mile 0.3 at Alpena, shall open on signal if at least three hours notice is given to the Dispatcher, Police Department, City of Alpena, Michigan. [CGD 82-025, 49 FR 17452, Apr. 24, 1984...

FOUNDRY LANDSCAPE LOOKING WESTNORTHWEST FROM MALLEABLE STOCK YARD CRANE, SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FOUNDRY LANDSCAPE LOOKING WEST-NORTHWEST FROM MALLEABLE STOCK YARD CRANE, SHOWING CRANE MOTOR AND MALLEABLE CUPOLAS WITH OPEN TOPS AND EMISSION RECOVERY DUCTS. - Stockham Pipe & Fittings Company, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

VIEW OF SOUTHWEST CORNER OF SECOND FLOOR STAIR HALL OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF SOUTHWEST CORNER OF SECOND FLOOR STAIR HALL OF PAULINE KILKER HOUSE SHOWING ARCHED OPENING IN FOREGROUND, FACING SOUTHWEST. - Pauline Kilker House, 1410 North Lincoln Avenue-3300 West Laurel Street, Tampa, Hillsborough County, FL

Giant ultrafast Kerr effect in superconductors

NASA Astrophysics Data System (ADS)

Robson, Charles W.; Fraser, Kieran A.; Biancalana, Fabio

2017-06-01

We study the ultrafast Kerr effect and high-harmonic generation in superconductors by formulating a model for a time-varying electromagnetic pulse normally incident on a thin-film superconductor. It is found that superconductors exhibit exceptionally large χ(3 ) due to the progressive destruction of Cooper pairs, and display high-harmonic generation at low incident intensities, and the highest nonlinear susceptibility of all known materials in the THz regime. Our theory opens up avenues for accessible analytical and numerical studies of the ultrafast dynamics of superconductors.

Validating the Novel Method of Measuring Cortisol Levels in Cetacean Skin by use of an ACTH Challenge in Bottlenose Dolphins

DTIC Science & Technology

2015-09-30

e.g. blubber biopsies). This process has shown to significantly raise both cortisol and aldosterone above baseline conditions and thus equals an...opening up a new avenue of research in physiological response studies following exposure to stressors. The current study will provide the validation... Physiology , 3: doi:10.1093/conphys/cov016 PUBLICATIONS Bechshøft TØ, Wright AJ, Teilmann J, Dietz R, Hansen M, Weisser JJ & Styrishave B. Developing a

[Autophagy in the cardiovascular system].

PubMed

Kheloufi, Marouane; Rautou, Pierre-Emmanuel; Boulanger, Chantal M

2017-03-01

Cardiovascular diseases are the leading cause of mortality worldwide. Studies regarding the role of autophagy in cardiac and vascular tissues have opened new therapeutic avenues to treat cardiovascular disorders. Altogether, these studies point out that autophagic activity needs to be maintained at an optimal level to preserve cardiovascular function. Reaching this goal constitutes a challenge for future efficient therapeutic strategies. The present review therefore highlights recent advances in the understanding of the role of autophagy in cardiovascular pathologies. © 2017 médecine/sciences – Inserm.

Exterior doorway detail south side of building (first floor) east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Exterior doorway detail south side of building (first floor) east inset porch; interior staircase visible in background - Fitzsimons General Hospital, Open Air Tuberculosis Ward, West Pennington Avenue & North Hickey Street Southwest Corner, Aurora, Adams County, CO

76 FR 15302 - Notice of Public Hearing for the Draft Environmental Impact Statement for the TRIDENT Support...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-21

.... April 21, 2011, at the Seattle Central Library, 1000 Fourth Avenue, Seattle, WA 98104. All meetings will start with an open house session from 6 p.m. to 7:30 p.m. followed by a presentation and public comment period from 7:30 p.m. to 9 p.m. The open house sessions will allow individuals the opportunity to review...

INTERIOR VIEW OF BATHROOM 1. NOTE THE ORIGINAL MOSAIC PATTERN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR VIEW OF BATHROOM 1. NOTE THE ORIGINAL MOSAIC PATTERN FLOOR TILE, ASBESTOS CEMENT WALL BOARD, AND OPEN TRANSOM OVER THE SHOWER DOORWAY. VIEW FACING WEST. - Hickam Field, Officers' Housing Type D, 111 Beard Avenue, Honolulu, Honolulu County, HI

Detail of west corner of front entry stair showing mission ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of west corner of front entry stair showing mission scrolls and sill of former living porch opening, facing east. - Albrook Air Force Station, Company Officer's Quarters, East side of Canfield Avenue, Balboa, Former Panama Canal Zone, CZ

25. Historic American Buildings Survey, Stevens Commercial Photographers, December 31, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. Historic American Buildings Survey, Stevens Commercial Photographers, December 31, 1927 Photocopy by Lyle E. Winkle, 1969 WEATHERLY BUILDING AND ORIENTAL THEATRE, LOOKING SOUTHEAST (TAKEN EVE OF THEATRE OPENING). - Oriental Theatre, 828 Southeast Grand Avenue, Portland, Multnomah County, OR

17. DETAIL OF CONTROL PANEL FOR FILTER #9: CONTROL SWITCHES ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. DETAIL OF CONTROL PANEL FOR FILTER #9: CONTROL SWITCHES CONTROL BY PERCENTAGE OF VALVE OPENINGS INFLUENT, EFFLUENT, DRAINAGE, BACKWASH AND SURFACE WASH. - F. E. Weymouth Filtration Plant, 700 North Moreno Avenue, La Verne, Los Angeles County, CA

Open-cage fullerene-like graphitic carbons as catalysts for oxidative dehydrogenation of isobutane.

PubMed

Liang, Chengdu; Xie, Hong; Schwartz, Viviane; Howe, Jane; Dai, Sheng; Overbury, Steven H

2009-06-10

We report herein a facile synthesis of fullerene-like cages, which can be opened and closed through simple thermal treatments. A glassy carbon with enclosed fullerene-like cages of 2-3 nm was synthesized through a soft-template approach that created open mesopores of 7 nm. The open mesopores provided access to the fullerene-like cages, which were opened and closed through heat treatments in air and inert gas at various temperatures. Catalytic measurements showed that the open cages displayed strikingly higher activity for the oxidative dehydrogenation of isobutane in comparison to the closed ones. We anticipate that this synthesis approach could unravel an avenue for pursuing fundamental understanding of the unique catalytic properties of graphitic carbon nanostructures.

Exploring the Sun with ALMA

NASA Astrophysics Data System (ADS)

Bastian, T. S.; Bárta, M.; Brajša, R.; Chen, B.; Pontieu, B. D.; Gary, D. E.; Fleishman, G. D.; Hales, A. S.; Iwai, K.; Hudson, H.; Kim, S.; Kobelski, A.; Loukitcheva, M.; Shimojo, M.; Skokić, I.; Wedemeyer, S.; White, S. M.; Yan, Y.

2018-03-01

The Atacama Large Millimeter/submillimeter Array (ALMA) Observatory opens a new window onto the Universe. The ability to perform continuum imaging and spectroscopy of astrophysical phenomena at millimetre and submillimetre wavelengths with unprecedented sensitivity opens up new avenues for the study of cosmology and the evolution of galaxies, the formation of stars and planets, and astrochemistry. ALMA also allows fundamentally new observations to be made of objects much closer to home, including the Sun. The Sun has long served as a touchstone for our understanding of astrophysical processes, from the nature of stellar interiors, to magnetic dynamos, non-radiative heating, stellar mass loss, and energetic phenomena such as solar flares. ALMA offers new insights into all of these processes.

[Programmed mouse genome modifications].

PubMed

Babinet, C

1998-02-01

The availability, in the mouse, of embryonic stem cells (ES cells) which have the ability to colonize the germ line of a developing embryo, has opened entirely new avenues to the genetic approach of embryonic development, physiology and pathology of this animal. Indeed, it is now possible, using homologous recombination in ES cells, to introduce mutations in any gene as long as it has been cloned. Thus, null as well as more subtle mutations can be created. Furthermore, scenarios are currently being derived which will allow one to generate conditional mutations. Taken together, these methods offer a tremendous tool to study gene function in vivo; they also open the way to creating murine models of human genetic diseases.

75 FR 10795 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice Time And Date: 2 p.m., Wednesday, March 24, 2010. Place: The United States Department of Labor Auditorium, Frances Perkins Building, 200 Constitution Avenue, NW., Washington, DC. Status: Open. Matters To Be Considered: The Commission...

6. Photograph of a photograph in possession of Rock Island ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photograph of a photograph in possession of Rock Island Arsenal Historical Office. BASEMENT, SHOWING ORIGINAL OPEN INTERIOR FLOOR PLAN. DATED C. 1898. - Rock Island Arsenal, Building No. 62, Rodman Avenue between First & Second Streets, Rock Island, Rock Island County, IL

31 CFR 357.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... which the Federal Reserve Banks are not open for business. Department means the United States Department... inspection at the Department of the Treasury Library, Room 1428, Main Treasury Building, 1500 Pennsylvania... Treasury Library, Room 1428, Main Treasury Building, 1500 Pennsylvania Avenue, NW., Washington, DC 20220,or...

76 FR 25683 - State Energy Advisory Board (STEAB); Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-05

... DEPARTMENT OF ENERGY Energy Efficiency and Renewable Energy State Energy Advisory Board (STEAB); Meeting AGENCY: Energy Efficiency and Renewable Energy, Department of Energy. ACTION: Notice of Open... Energy Efficiency and Renewable Energy, 1000 Independence Avenue, SW., Washington DC 20585; or e-mail...

Hazardous Waste Cleanup: Chemours Repauno in Gibbstown, New Jersey

EPA Pesticide Factsheets

Chemours Repauno, a former DuPont Company, is located at 200 North Repauno Avenue in Gibbstown, New Jersey. The DuPont Gibbstown plant occupies nearly 1,900 acres along the Delaware River in Gibbstown, Greenwich Township. The plant, which opened in 1880,

77 FR 37101 - Open Meeting of the Taxpayer Advocacy Panel Refund Processing Communications Project Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

...-1227 or 414-231-2360, or write TAP Office Stop 1006MIL, 211 West Wisconsin Avenue, Milwaukee, WI 53203... issues. Dated: June 13, 2012. Louis Morizio, Acting TAP Director, Taxpayer Advocacy Panel. [FR Doc. 2012...

76 FR 60080 - Cedar Creek and Belle Grove National Historical Park Advisory Commission; Notice of Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

...: Warren County Government Center, 220 North Commerce Avenue, Front Royal, VA. Date: March 15, 2012... at 8:30 a.m. and are open to the public. FOR FURTHER INFORMATION CONTACT: Diann Jacox, Superintendent...

Auditorily-induced illusory self-motion: a review.

PubMed

Väljamäe, Aleksander

2009-10-01

The aim of this paper is to provide a first review of studies related to auditorily-induced self-motion (vection). These studies have been scarce and scattered over the years and over several research communities including clinical audiology, multisensory perception of self-motion and its neural correlates, ergonomics, and virtual reality. The reviewed studies provide evidence that auditorily-induced vection has behavioral, physiological and neural correlates. Although the sound contribution to self-motion perception appears to be weaker than the visual modality, specific acoustic cues appear to be instrumental for a number of domains including posture prosthesis, navigation in unusual gravitoinertial environments (in the air, in space, or underwater), non-visual navigation, and multisensory integration during self-motion. A number of open research questions are highlighted opening avenue for more active and systematic studies in this area.

SOUTHWEST VIEW OF FOUNDRY FROM TOP OF GREY IRON CUPOLA ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTHWEST VIEW OF FOUNDRY FROM TOP OF GREY IRON CUPOLA SHOWING OPENED TOP OF CUPOLA WITH EMISSION RECOVERY DUCT COMING OFF. TO THE RIGHT IS THE STORAGE AND SHIPPING BUILDING. - Stockham Pipe & Fittings Company, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

12 CFR 271.3 - Published information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... from the Publications Services of the Federal Reserve Board, 20th Street and Constitution Avenue, N.W... Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) FEDERAL OPEN MARKET COMMITTEE RULES REGARDING AVAILABILITY OF INFORMATION § 271.3 Published information. (a) Federal Register. The Committee publishes in the...

12 CFR 271.3 - Published information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... from the Publications Services of the Federal Reserve Board, 20th Street and Constitution Avenue, N.W... Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) FEDERAL OPEN MARKET COMMITTEE RULES REGARDING AVAILABILITY OF INFORMATION § 271.3 Published information. (a) Federal Register. The Committee publishes in the...

Uncoated and Polymer Coated Titanium Dioxide (TiO2)Nanoparticles: Differences in Deposition and Charge Characteristics

EPA Science Inventory

The advent of nanotechnology has opened up several potential avenues starting from the development of advanced manufacturing processes, revolutionary medical treatments, new consumer products, environmental applications, pollution control, etc. The backbone of this new leading-ed...

Publicity.

ERIC Educational Resources Information Center

Chisholm, Joan

Publicity for preschool cooperatives is described. Publicity helps produce financial support for preschool cooperatives. It may take the form of posters, brochures, newsletters, open house, newspaper coverage, and radio and television. Word of mouth and general good will in the community are the best avenues of publicity that a cooperative nursery…

A 2-D guinea pig lung proteome map

USDA-ARS?s Scientific Manuscript database

Guinea pigs represent an important model for a number of infectious and non-infectious pulmonary diseases. The guinea pig genome has recently been sequenced to full coverage, opening up new research avenues using genomics, transcriptomics and proteomics techniques in this species. In order to furth...

Detail view to show the bronze gates hanging in the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view to show the bronze gates hanging in the driveway portals; the open grille is foliated and crowned with patriotic eagle emblems - United States Department of Commerce, Bounded by Fourteenth, Fifteenth, and E streets and Constitution Avenue, Washington, District of Columbia, DC

A single frame: imaging live cells twenty-five years ago.

PubMed

Fink, Rachel

2011-07-01

In the mid-1980s live-cell imaging was changed by the introduction of video techniques, allowing new ways to collect and store data. The increased resolution obtained by manipulating video signals, the ability to use time-lapse videocassette recorders to study events that happen over long time intervals, and the introduction of fluorescent probes and sensitive video cameras opened research avenues previously unavailable. The author gives a personal account of this evolution, focusing on cell migration studies at the Marine Biological Laboratory 25 years ago. Copyright © 2011 Wiley-Liss, Inc.

Gene networks and the evolution of plant morphology.

PubMed

Das Gupta, Mainak; Tsiantis, Miltos

2018-06-06

Elaboration of morphology depends on the precise orchestration of gene expression by key regulatory genes. The hierarchy and relationship among the participating genes is commonly known as gene regulatory network (GRN). Therefore, the evolution of morphology ultimately occurs by the rewiring of gene network structures or by the co-option of gene networks to novel domains. The availability of high-resolution expression data combined with powerful statistical tools have opened up new avenues to formulate and test hypotheses on how diverse gene networks influence trait development and diversity. Here we summarize recent studies based on both big-data and genetics approaches to understand the evolution of plant form and physiology. We also discuss recent genome-wide investigations on how studying open-chromatin regions may help study the evolution of gene expression patterns. Copyright © 2018. Published by Elsevier Ltd.

Human white matter and knowledge representation

PubMed Central

2018-01-01

Understanding how knowledge is represented in the human brain is a fundamental challenge in neuroscience. To date, most of the work on this topic has focused on knowledge representation in cortical areas and debated whether knowledge is represented in a distributed or localized fashion. Fang and colleagues provide evidence that brain connections and the white matter supporting such connections might play a significant role. The work opens new avenues of investigation, breaking through disciplinary boundaries across network neuroscience, computational neuroscience, cognitive science, and classical lesion studies. PMID:29698391

Human white matter and knowledge representation.

PubMed

Pestilli, Franco

2018-04-01

Understanding how knowledge is represented in the human brain is a fundamental challenge in neuroscience. To date, most of the work on this topic has focused on knowledge representation in cortical areas and debated whether knowledge is represented in a distributed or localized fashion. Fang and colleagues provide evidence that brain connections and the white matter supporting such connections might play a significant role. The work opens new avenues of investigation, breaking through disciplinary boundaries across network neuroscience, computational neuroscience, cognitive science, and classical lesion studies.

Measuring and Validating Levels of Steroid Hormones in the Skin of Bottlenose Dolphins (Tursiops Truncatus)

DTIC Science & Technology

2015-09-30

relationship between serum and skin concentrations of aldosterone , c) how long it takes for aldosterone , corticosterone, and cortisol to be measurable in...opening up a new avenue of research in physiological response studies. REFERENCES Bechshoft T, Wright A, Weisser JJ, Teilmann J, Dietz R, Hansen M...Björklund E & Styrishave B. Developing a new research tool for use in free-ranging cetaceans: recovering cortisol from harbor porpoise skin. Conservation Physiology , 3: doi:10.1093/conphys/cov016

The Changing Face of Hypophosphatemic Disorders in the FGF-23 Era

PubMed Central

Lee, Janet Y.; Imel, Erik A.

2014-01-01

In the past decade, research in genetic disorders of hypophosphatemia has significantly expanded our understanding of phosphate metabolism. X-linked hypophosphatemia (XLH) is the most common inherited form of rickets due to renal phosphate wasting. Recent understanding of the mechanisms of disease and role of fibroblast growth factor 23 (FGF-23) in XLH and other hypophosphatemic disorders have opened new potential therapeutic avenues. We will discuss the current standard of treatment for XLH as well as promising future directions under study. PMID:23858620

Towards fabrication of 3D printed medical devices to prevent biofilm formation.

PubMed

Sandler, Niklas; Salmela, Ida; Fallarero, Adyary; Rosling, Ari; Khajeheian, Mohammad; Kolakovic, Ruzica; Genina, Natalja; Nyman, Johan; Vuorela, Pia

2014-01-01

The use of three-dimensional (3D) printing technologies is transforming the way that materials are turned into functional devices. We demonstrate in the current study the incorporation of anti-microbial nitrofurantoin in a polymer carrier material and subsequent 3D printing of a model structure, which resulted in an inhibition of biofilm colonization. The approach taken is very promising and can open up new avenues to manufacture functional medical devices in the future. Copyright © 2013 Elsevier B.V. All rights reserved.

77 FR 69843 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice November 15, 2012. TIME AND DATE: 1:00 p.m., Thursday, December 6, 2012. PLACE: The Richard V. Backley Hearing Room, Room 511N, 1331 Pennsylvania Avenue NW., Washington, DC 20004 (entry from F Street entrance). STATUS: Open...

77 FR 66841 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice November 2, 2012. TIME AND DATE: 10:00 a.m., Friday, November 16, 2012. PLACE: The Richard V. Backley Hearing Room, Room 511N, 1331 Pennsylvania Avenue NW., Washington, DC 20004 (entry from F Street entrance). STATUS: Open...

78 FR 4145 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice January 15, 2013. TIME AND DATE: 2:00 p.m., Thursday, January 31, 2013. PLACE: The Richard V. Backley Hearing Room, Room 511N, 1331 Pennsylvania Avenue NW, Washington, DC 20004 (entry from F Street entrance). STATUS: Open. MATTERS...

78 FR 9390 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-08

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice February 5, 2013. TIME AND DATE: 2:00 p.m., Thursday, February 21, 2013 PLACE: The Richard V. Backley Hearing Room, Room 511N, 1331 Pennsylvania Avenue NW., Washington, DC 20004 (entry from F Street entrance) STATUS: Open MATTERS...

76 FR 7568 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Meeting February 3, 2011. TIME AND DATE: 10 a.m., Thursday, February 17, 2011. PLACE: The Richard V. Backley Hearing Room, 9th Floor, 601 New Jersey Avenue, NW., Washington, DC. STATUS: Open. MATTERS TO BE CONSIDERED: The Commission will...

76 FR 7568 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Meeting February 3, 2011. TIME AND DATE: 10 a.m., Thursday, February 24, 2011. PLACE: The Richard V. Backley Hearing Room, 9th Floor, 601 New Jersey Avenue, NW., Washington, DC. STATUS: Open. MATTERS TO BE CONSIDERED: The Commission will...

75 FR 55329 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-10

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice September 3, 2010. TIME AND DATE: 10 a.m., Thursday, September 16, 2010. PLACE: The Richard V. Backley Hearing Room, 9th Floor, 601 New Jersey Avenue, NW., Washington, DC. STATUS: Open. MATTERS TO BE CONSIDERED: The Commission will...

78 FR 9391 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-08

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice February 5, 2013. TIME AND DATE: 10:00 a.m., Thursday, February 21, 2013. PLACE: The Richard V. Backley Hearing Room, Room 511N, 1331 Pennsylvania Avenue NW., Washington, DC 20004 (entry from F Street entrance). STATUS: Open...

78 FR 4145 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice January 15, 2013. TIME AND DATE: 10:00 a.m., Thursday, January 31, 2013. PLACE: The Richard V. Backley Hearing Room, Room 511N, 1331 Pennsylvania Avenue NW, Washington, DC 20004 (entry from F Street entrance). STATUS: Open. MATTERS...

77 FR 9658 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-17

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Meeting February 14, 2012. TIME AND DATE: 10 a.m., Thursday, February 23, 2012. PLACE: The Richard V. Backley Hearing Room, 9th Floor, 601 New Jersey Avenue NW., Washington, DC. STATUS: Open. MATTERS TO BE CONSIDERED: The Commission will...

31 CFR 357.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... any day other than a Saturday, Sunday, or other day on which the Federal Reserve Banks are not open... inspection at the Department of the Treasury Library, Room 1428, Main Treasury Building, 1500 Pennsylvania... Treasury Library, Room 1428, Main Treasury Building, 1500 Pennsylvania Avenue, NW., Washington, DC 20220,or...

20 CFR 501.8 - Clerk of the Office of the Appellate Boards; docket of proceedings; records.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Boards is located at 200 Constitution Avenue, NW., Washington, DC 20210. The Office of the Clerk is open during business hours on all days except Saturdays, Sundays and Federal holidays, from 8:30 a.m. to 5 p.m...

20 CFR 501.8 - Clerk of the Office of the Appellate Boards; docket of proceedings; records.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Boards is located at 200 Constitution Avenue, NW., Washington, DC 20210. The Office of the Clerk is open during business hours on all days except Saturdays, Sundays and Federal holidays, from 8:30 a.m. to 5 p.m...

20 CFR 501.8 - Clerk of the Office of the Appellate Boards; docket of proceedings; records.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Boards is located at 200 Constitution Avenue, NW., Washington, DC 20210. The Office of the Clerk is open during business hours on all days except Saturdays, Sundays and Federal holidays, from 8:30 a.m. to 5 p.m...

78 FR 14101 - Homeland Security Science and Technology Advisory Committee (HSSTAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-04

... Technology Advisory Committee (HSSTAC) AGENCY: Science and Technology Directorate, DHS. ACTION: Committee... Technology Advisory Committee (HSSTAC) will meet on March 21, 2013 in Washington, DC The meeting will be open... the Department of Homeland Security (DHS), Science and Technology Directorate, 1120 Vermont Avenue NW...

INTERIOR VIEW, WEST CHAMBER OVER THE SALOON FROM THE EAST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR VIEW, WEST CHAMBER OVER THE SALOON FROM THE EAST. THE SIX-PANEL DOOR VISIBLE IN THE MAIN PASSAGE OPENS ONTO THE ATTIC STAIRS. THE SERVICE STAIR DOES NOT EXTEND CONTINUOUSLY FROM CELLAR TO ATTIC - The Woodlands, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

77 FR 71828 - Meeting of the Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-04

... recommended for inclusion on future Joint Board examinations in actuarial mathematics and methodology referred... meeting of the Advisory Committee on Actuarial Examinations (portions of which will be open to the public... Committee on Actuarial Examinations will meet at the Internal Revenue Service, 1111 Constitution Avenue NW...

78 FR 70944 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Meeting Notice November 22, 2013. TIME AND DATE: 1:00 p.m., Thursday, December 5, 2013. PLACE: The Richard V. Backley Hearing Room, Room 511N, 1331 Pennsylvania Avenue NW., Washington, DC 20004 (entry from F Street entrance). STATUS: Open...

77 FR 69843 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Meeting Notice November 15, 2012. TIME AND DATE: 10:00 a.m., Thursday, December 6, 2012. PLACE: The Richard V. Backley Hearing Room, Room 511N, 1331 Pennsylvania Avenue NW., Washington, DC 20004 (entry from F Street entrance). STATUS: Open...

75 FR 38096 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice June 21, 2010. TIME AND DATE: 10 a.m., Thursday, July 1, 2010. PLACE: The Richard V. Backley Hearing Room, 9th Floor, 601 New Jersey Avenue, NW., Washington, DC. STATUS: Open. MATTERS TO BE CONSIDERED: The Commission will consider...

78 FR 70944 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Meeting Notice November 22, 2013. TIME AND DATE: 10:00 a.m., Thursday, December 5, 2013. PLACE: The Richard V. Backley Hearing Room, Room 511N, 1331 Pennsylvania Avenue NW., Washington, DC 20004 (entry from F Street entrance). STATUS: Open...

75 FR 48336 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-10

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Notice Time and Date: 3 p.m., Thursday, August 12, 2010. Place: The Richard V. Backley Hearing Room, 9th Floor, 601 New Jersey Avenue, NW., Washington, DC. Status: Open. Matters To Be Considered: The Commission will consider and act upon the...

77 FR 13126 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-05

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Meeting Notice TIME AND DATE: 10 a.m., Thursday, March 8, 2012. PLACE: The Richard V. Backley Hearing Room, 9th Floor, 601 New Jersey Avenue NW., Washington, DC. STATUS: Open. MATTERS TO BE CONSIDERED: The Commission will consider and act upon the...

Child Language Research: Building on the Past, Looking to the Future.

ERIC Educational Resources Information Center

Perera, Katharine

1994-01-01

Outlines descriptive, theoretical, and methodological advances in child language research since the first volume of the "Journal of Child Language" was published. Papers in this volume build on earlier research, point the way to new research avenues, and open new lines of inquiry. (Contains 36 references.) (JP)

Multi-Dimensional Optimization for Cloud Based Multi-Tier Applications

ERIC Educational Resources Information Center

Jung, Gueyoung

2010-01-01

Emerging trends toward cloud computing and virtualization have been opening new avenues to meet enormous demands of space, resource utilization, and energy efficiency in modern data centers. By being allowed to host many multi-tier applications in consolidated environments, cloud infrastructure providers enable resources to be shared among these…

22. FROM CREW'S BERTHING, LOOKING TOWARDS STERN, SHOWING DETAIL OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. FROM CREW'S BERTHING, LOOKING TOWARDS STERN, SHOWING DETAIL OF INTERIOR LICKING MECHANISM OF HATCH DOOR OPENING TO FANTAIL (INTERIOR SIDE OF DOOR IN IMAGE 22). - U.S. Coast Guard Cutter WHITE LUPINE, U.S. Coast Guard Station Rockland, east end of Tillson Avenue, Rockland, Knox County, ME

Citizen Participation in Broadcast Licensing Before the FCC.

ERIC Educational Resources Information Center

Grundfest, Joseph A.

This report examines the public's role in determining the dimensions of the public interest in the regulation of broadcast services. Chapter II describes some of the avenues open to citizens to influence the Federal Communication Commission, including: (1) direct contact between broadcasters and citizens, (2) citizen participation in the…

Interior view, firstfloor room extending between the north wall of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior view, first-floor room extending between the north wall of the rotunda and the rotunda extensions north exterior wall, looking southwest. The small doorway at center opens onto the vestibule letting onto the rotunda. - U. S. Naval Asylum, Biddle Hall, Gray's Ferry Avenue, Philadelphia, Philadelphia County, PA

Fire Protection System for an Atrium Satisfies Code Intent

ERIC Educational Resources Information Center

Boehmer, Donald J.; Jensen, Rolf

1975-01-01

The Civic Center in Scarborough, Ontario, has an open interior design that incorporates an atrium. Fire protection elements include automatic sprinklers, provisions for efficient exiting of building occupants, and smoke evacuation by gravity exhaust. (Available from 1221 Avenue of the Americas, New York, NY 10020, $15.00 annually.) (Author/MLF)

75 FR 67145 - Sunshine Act: Public Hearing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-01

... OVERSEAS PRIVATE INVESTMENT CORPORATION Sunshine Act: Public Hearing TIME AND DATE: 2 p.m... Avenue, NW., Washington, DC. STATUS: Hearing open to the Public at 2 p.m. PURPOSE: Public Hearing in... hearing orally must provide advance notice to OPIC's Corporate Secretary no later than 5 p.m. Thursday...

77 FR 30031 - Sunshine Notice-June 6, 2012 Public Hearing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... OVERSEAS PRIVATE INVESTMENT CORPORATION Sunshine Notice--June 6, 2012 Public Hearing TIME AND DATE..., 1100 New York Avenue NW., Washington, DC. STATUS: Hearing OPEN to the Public at 2:00 p.m. PURPOSE: Public Hearing in conjunction with each meeting of OPIC's Board of Directors, to afford an opportunity...

76 FR 60559 - Sunshine Notice, Public Hearing, October 19, 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... OVERSEAS PRIVATE INVESTMENT CORPORATION Sunshine Notice, Public Hearing, October 19, 2011 TIME AND..., 1100 New York Avenue, NW., Washington, DC. STATUS: Hearing OPEN to the Public at 2 p.m. PURPOSE: Public Hearing in conjunction with each meeting of OPIC's Board of Directors, to afford an opportunity for any...

76 FR 34750 - Advisory Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

... inclusion on future Joint Board examinations in actuarial mathematics and methodology referred to in 29 U.S... Committee on Actuarial Examinations (a portion of which will be open to the public) in Washington, DC at the... Actuarial Examinations will meet in at the Internal Revenue Service Building, 1111 Constitution Avenue, NW...

75 FR 4630 - Open Meeting of the Area 6 Taxpayer Advocacy Panel (Including the States of Arizona, Colorado...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-28

... 1-888-912-1227 or 206-220-6098, or write TAP Office, 915 2nd Avenue, MS W-406, Seattle, WA 98174 or.... Reason for Late Notice: Due to year end leave and mandatory training in January key TAP staff were...

76 FR 61706 - Meeting of the Chronic Fatigue Syndrome Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Meeting of the Chronic Fatigue Syndrome Advisory Committee... Chronic Fatigue Syndrome Advisory Committee (CFSAC) will hold a meeting. The meeting will be open to the... Fatigue Syndrome Advisory Committee, Department of Health and Human Services; 200 Independence Avenue, SW...

77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-12

... owner displayed on the Wise Avenue Bridge signage that stated a 48-hour advance notice was required to open the draw bridge. This signage portrayed improper operational information since the current operation regulation had not changed. The Coast Guard determined the signage that stated a 48-hour advance...

78 FR 43968 - Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-22

... UNITED STATES INSTITUTE OF PEACE Notice of Meeting AGENCY: United States Institute of Peace. Date/Time: Monday, July 29, 2013 (9:30 a.m.-3:00 p.m.) Location: 2301 Constitution Avenue NW., Washington, DC 20037. Status: Open Session--Portions may be closed pursuant to Subsection (c) of Section 552(b...

75 FR 35000 - Blue Ribbon Commission on America's Nuclear Future, Disposal Subcommittee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-21

... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future, Disposal Subcommittee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of Open Meeting. SUMMARY: This... Avenue, SW., Washington DC 20585, e-mail to [email protected]nuclear.energy.gov , or post comments on the...

78 FR 21197 - Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

.... 2013-08152 Filed 4-8-13; 8:45 am] BILLING CODE 6820-AR-P ...: Date/Time: Friday, April 19, 2013 (9:00 a.m.-3:00 p.m.). Location: 2301 Constitution Avenue NW., Washington, DC 20037. Status: Open Session--Portions may be closed pursuant to Subsection (c) of Section 552...

Biosensors and Your Health: What's Your Body Trying to Tell You?

MedlinePlus

... of our normal health care routines. New sensor technologies are opening avenues to better health. Researchers are working to develop the biosensors of tomorrow. These could provide access to better health in ways we can’t yet imagine. Related Stories Keep an Eye on Your Eyes Struggling to ...

77 FR 28387 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Meeting Notice May 9, 2012. TIME AND DATE: 10:00 a.m., Thursday, May 17, 2012. PLACE: The Richard V. Backley Hearing Room, 9th Floor, 601 New Jersey Avenue NW., Washington, DC. STATUS: Open. MATTERS TO BE CONSIDERED: The Commission will...

77 FR 31612 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION Sunshine Act Meeting Notice May 22, 2012. TIME AND DATE: 10:00 a.m., Thursday, May 31, 2012. PLACE: The Richard V. Backley Hearing Room, 9th Floor, 601 New Jersey Avenue NW., Washington, DC. STATUS: Open. MATTERS TO BE CONSIDERED: The Commission will...

75 FR 50009 - Sunshine Act; Public Hearing, September 9, 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... OVERSEAS PRIVATE INVESTMENT CORPORATION Sunshine Act; Public Hearing, September 9, 2010 TIME AND DATE: 2 p.m., Thursday, September 9, 2010. PLACE: Offices of the Corporation, Twelfth Floor Board Room, 1100 New York Avenue, NW., Washington, DC. STATUS: Hearing open to the Public at 2 p.m. PURPOSE: Public...

The past, present, and future of Leishmania genomics and transcriptomics

PubMed Central

Cantacessi, Cinzia; Dantas-Torres, Filipe; Nolan, Matthew J.; Otranto, Domenico

2015-01-01

It has been nearly 10 years since the completion of the first entire genome sequence of a Leishmania parasite. Genomic and transcriptomic analyses have advanced our understanding of the biology of Leishmania, and shed new light on the complex interactions occurring within the parasite–host–vector triangle. Here, we review these advances and examine potential avenues for translation of these discoveries into treatment and control programs. In addition, we argue for a strong need to explore how disease in dogs relates to that in humans, and how an improved understanding in line with the ‘One Health’ concept may open new avenues for the control of these devastating diseases. PMID:25638444

Hydrologic data for urban storm runoff in the Denver metropolitan area, Colorado

USGS Publications Warehouse

Gibbs, Johnnie W.; Doefer, John T.

1982-01-01

Urban storm-runoff data collected from April through September 1981 from nine Denver Nationwide Urban Runoff Program sites, urban storm-runoff data collected from April 1980 through September 1981 from ten South Platte River Study sites, and rainfall-runoff simulation data from two sites for June 1980 and May 1981 are presented in this report. The Denver Nationwide Urban Runoff Program sites were two single-family residential areas, two multifamily residential areas, one commercial area (shopping center), one mixed commercial and multifamily residential area, one natural area (open space), and two detention ponds. The South Platte River Study sites were six tributaries of the South Platte River and four instream sites on the South Platte River. The tributary sites were Bear Creek at mouth, at Sheridan; Harvard Gulch at Harvard Park, at Denver; Sanderson Gulch at mouth, at Denver; Weir Gulch at mouth, at Denver; Lakewood Gulch at mouth, at Denver; and Cherry Creek at Denver. The instream sites were South Platte River at Littleton; South Platte River at Florida Avenue, at Denver; South Platte River at Denver; and South Platte River at 50th Avenue, at Denver. The rainfall-runoff simulation sites were North Avenue at Denver Federal Center, at Lakewood and Rooney Gulch at Rooney Ranch, near Morrison. Precipitation, rainfall-runoff, water-quality data, and basin characteristics were collected at the urban storm-runoff sites. The urban storm-runoff data may be used to characterize runoff loading for various land-use types in Denver and other semiarid regions. (USGS)

Symmetry Breaking and Optical Negative Index of Closed Nanorings

NASA Astrophysics Data System (ADS)

Kante, Boubacar; Park, Yong-Shik; O'Brien, Kevin; Shuldman, Daniel; Lanzillotti-Kimura, Norberto; Wong, Zi; Yin, Xiaobo; Zhang, Xiang; UC Berkeley Team

2013-03-01

We report the first experimental demonstration of broadband negative-index metamaterial made solely of closed metallic nanorings. Using symmetry breaking that negatively couples the discrete nanorings, we measured negative phase delay in our composite chess metamaterial. Our approach open avenues towards topological nanophotonics with on demand linear and non-linear responses.

Virtual Soil Monoliths: Blending Traditional and Web-Based Educational Approaches

ERIC Educational Resources Information Center

Krzic, Maja; Strivelli, Rachel A.; Holmes, Emma; Grand, Stephanie; Dyanatkar, Saeed; Lavkulich, Les M.; Crowley, Chris

2013-01-01

Since soil plays a crucial role in all aspects of global environmental change, it is essential that post-secondary institutions provide students with a strong foundation in soil science concepts including soil classification. The onset of information technology (IT) and web-based multimedia have opened new avenues to better incorporate…

Lattice enclosure, cellar passage, main block, looking south. Functioning with ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Lattice enclosure, cellar passage, main block, looking south. Functioning with vents opened through the masonry in the east and west walls, this partition provided a secure and aerated storage area for foodstuffs used in the nearby kitchen. - Lazaretto Quarantine Station, Wanamaker Avenue and East Second Street, Essington, Delaware County, PA

Guiding Curriculum Development: Student Perceptions for the Second Language Learning in Technology-Enhanced Learning Environments

ERIC Educational Resources Information Center

Gürleyik, Sinan; Akdemir, Elif

2018-01-01

Developing curriculum to enhance student learning is the primer purpose of all curricular activities. Availability of recent tools supporting to teach various skills including reading, listening, speaking and writing has opened a new avenue for curricular activities in technology-enhanced learning environments. Understanding the perceptions of…

18. Interior view of large unoccupied meeting/gathering room looking towards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Interior view of large unoccupied meeting/gathering room looking towards small stage and opened doorway to exterior vestibule; showing through wall air conditioning unit; north end of east wing on main floor; view to southwest. - Ellsworth Air Force Base, Group Administration & Secure Storage Building, 2372 Westover Avenue, Blackhawk, Meade County, SD

Information Technologies and Globalization: New Perspectives of Teaching Learning Process

ERIC Educational Resources Information Center

Hussain, Irshad

2008-01-01

This article discusses how information technologies and globalization have opened new avenues and horizons for educators and learners. It discusses different experiences of using information and communication technologies (ICTs) in teaching learning process the world over in the age of globalization. It focuses on the ways these new trends have…

Revitalizing Theory in Library and Information Science: The Contribution of Process Philosophy

ERIC Educational Resources Information Center

Jones, Bonna

2005-01-01

Two main traditions now operate in philosophy, influencing the choice about which theories are appropriate in library and information science (LIS). A third tradition, known as process philosophy, gives prominence to human knowledge as an organically integrated, self-sustaining whole, thereby opening another avenue for the effort to revitalize…

32 CFR Appendix B to Part 552 - Non-Permit Access Routes

Code of Federal Regulations, 2010 CFR

2010-07-01

... Limits) Lincoln Avenue (Madigan to EH 391179) 3. The Solo Point Road is open to Weyerhauser Corporation... Steilacoom-DuPont Road (EH 286156 to EH 302227). Pacific Highway Southeast (EH 232119 to EH 250141). Washington State Route 507 (EH 363061 to EH 429144). Goodacre (unpaved) and Rice Kandle (paved) Roads (EH...

32 CFR Appendix B to Part 552 - Non-Permit Access Routes

Code of Federal Regulations, 2011 CFR

2011-07-01

... Limits) Lincoln Avenue (Madigan to EH 391179) 3. The Solo Point Road is open to Weyerhauser Corporation... Steilacoom-DuPont Road (EH 286156 to EH 302227). Pacific Highway Southeast (EH 232119 to EH 250141). Washington State Route 507 (EH 363061 to EH 429144). Goodacre (unpaved) and Rice Kandle (paved) Roads (EH...

32 CFR Appendix B to Part 552 - Non-Permit Access Routes

Code of Federal Regulations, 2012 CFR

2012-07-01

... Limits) Lincoln Avenue (Madigan to EH 391179) 3. The Solo Point Road is open to Weyerhauser Corporation... Steilacoom-DuPont Road (EH 286156 to EH 302227). Pacific Highway Southeast (EH 232119 to EH 250141). Washington State Route 507 (EH 363061 to EH 429144). Goodacre (unpaved) and Rice Kandle (paved) Roads (EH...

76 FR 65780 - Open Meeting of the President's Advisory Council on Financial Capability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

..., the Department will make all statements available in their original format, including any business or... Pennsylvania Avenue, NW., Washington, DC, 20220, on official business days between the hours of 10 a.m. and 5 p... strategic areas: National Strategy, Financial Access, Research and Evaluation, Partnerships, and Youth. The...

Problematization as Activism: Disrupting the Neoliberal Education Project through the "Work of Thought"

ERIC Educational Resources Information Center

Pickup, Austin

2017-01-01

In this article, Austin Pickup centers Foucault's concept of "problematization" as an important methodological tool for displacing neoliberalism from its stable perch atop a perceived absence of other possibilities. According to Pickup, the genealogical analysis envisaged and practiced by Foucault opens up new avenues by indicating not…

12 CFR 271.4 - Records available for public inspection and copying.

Code of Federal Regulations, 2012 CFR

2012-01-01

... copying. 271.4 Section 271.4 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) FEDERAL OPEN MARKET.... weekdays, at the Freedom of Information Office of the Board of Governors of the Federal Reserve System, 20th Street and Constitution Avenue, N.W., Washington, D.C. 20551 (the pedestrian entrance is on C...

12 CFR 271.4 - Records available for public inspection and copying.

Code of Federal Regulations, 2010 CFR

2010-01-01

... copying. 271.4 Section 271.4 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) FEDERAL OPEN MARKET.... weekdays, at the Freedom of Information Office of the Board of Governors of the Federal Reserve System, 20th Street and Constitution Avenue, N.W., Washington, D.C. 20551 (the pedestrian entrance is on C...

12 CFR 271.4 - Records available for public inspection and copying.

Code of Federal Regulations, 2014 CFR

2014-01-01

... copying. 271.4 Section 271.4 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) FEDERAL OPEN MARKET.... weekdays, at the Freedom of Information Office of the Board of Governors of the Federal Reserve System, 20th Street and Constitution Avenue, N.W., Washington, D.C. 20551 (the pedestrian entrance is on C...

78 FR 70358 - Sunshine Act Meeting Notice-December 12, 2013 Board of Directors Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-25

... OVERSEAS PRIVATE INVESTMENT CORPORATION Sunshine Act Meeting Notice--December 12, 2013 Board of Directors Meeting TIME AND DATE: Thursday, December 12, 2013, 2 p.m. (OPEN Portion), 2:15 p.m. (CLOSED Portion). PLACE: Offices of the Corporation, Twelfth Floor Board Room, 1100 New York Avenue NW...

An Integration of Mobile Applications into Physical Education Programs

ERIC Educational Resources Information Center

Yu, Hyeonho; Kulinna, Pamela Hodges; Lorenz, Kent A.

2018-01-01

Even though technology in physical education has the potential to open up a variety of teaching and learning avenues by enhancing active experiences to help students develop the skills, attitudes, knowledge and behaviors needed for a lifetime of physical activity, some teachers may have a hard time finding ways to integrate technology into their…

View looking south along the main corridor on the third ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View looking south along the main corridor on the third floor of the south wing. The openings along the top of the corridor walls allowed for the movement of air and light between the corridor and the resident rooms. - U. S. Naval Asylum, Biddle Hall, Gray's Ferry Avenue, Philadelphia, Philadelphia County, PA

Low and High Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Spasticity

ERIC Educational Resources Information Center

Valle, Angela C.; Dionisio, Karen; Pitskel, Naomi Bass; Pascual-Leone, Alvaro; Orsati, Fernanda; Ferreira, Merari J. L.; Boggio, Paulo S.; Lima, Moises C.; Rigonatti, Sergio P.; Fregni, Felipe

2007-01-01

The development of non-invasive techniques of cortical stimulation, such as transcranial magnetic stimulation (TMS), has opened new potential avenues for the treatment of neuropsychiatric diseases. We hypothesized that an increase in the activity in the motor cortex by cortical stimulation would increase its inhibitory influence on spinal…

Copper phthalocyanine-based CMPs with various internal structures and functionalities.

PubMed

Ding, Xuesong; Han, Bao-Hang

2015-08-18

Several kinds of copper phthalocyanine-based conjugated microporous polymers have been synthesized, which present enhanced long-wavelength photon absorption capability and high efficiency for singlet oxygen generation under low energy light irradiation. This strategy opens a facile avenue towards expanding the scope of phthalocyanine-based porous materials with various internal structures and functionalities.

Women's Declining Employment with Access to Higher Education: Issues and Challenges

ERIC Educational Resources Information Center

Sangar, Sunita

2014-01-01

Access to higher education opened up avenues for more women workforce in decent employment contributing to the national economy. Government policies/schemes played a significant role in improving this significant indicator of women empowerment. This access also had an impact on their enrolment and choice of subjects but was accompanied by several…

Blueberries on Earth and Mars: Some Correlations Between Andean Paleosols, Geothermal Pipes in Navajo Sandstone and Terra Meridiani on Mars

NASA Astrophysics Data System (ADS)

Mahaney, W. C.; Milner, M. W.; Netoff, D. I.; Dohm, J. M.; Sodhi, R. N. S.; Aufreiter, S.; Hancock, R. G. V.; Bezada, M.; Kalm, V.; Malloch, D.

2006-03-01

The origin of "blueberries" on Mars and their relationship to similar concretionary forms on Earth invokes a process of variable redox conditions in underground fluids. The possible role of microorganisms in the origin of bluberries opens an avenue for biological investigations.

51. Projection room, looking SW. Original Movietone projection equipment intact. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

51. Projection room, looking SW. Original Movietone projection equipment intact. Old photo label identifying directional view is inaccurate. This image proves the projection room was expanded southward from its original design prior to the theatre's opening (see also photo WA-197-36). - Fox Theater, Seventh Avenue & Olive Way, Seattle, King County, WA

80. Photocopied August 1978. VIEW OF THE POWER HOUSE FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

80. Photocopied August 1978. VIEW OF THE POWER HOUSE FROM PORTAGE AVENUE ON GRAND OPENING DAY, OCTOBER 25, 1902. THE PUMP HOUSE ON THE WEST END OF THE POWER HOUSE WAS STILL INCOMPLETE AT THIS TIME. (407) - Michigan Lake Superior Power Company, Portage Street, Sault Ste. Marie, Chippewa County, MI

77 FR 21155 - Open Meeting of the Taxpayer Advocacy Panel Return Processing Delays Project Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-09

... 4:30 p.m. and Friday, June 1st from 8 a.m. to 12:00 noon Pacific Time at TAP Office, 915 2nd Avenue... more information please contact Ms. Spinks at 1-888-912-1227 or 206-220-6098, or write TAP Office, 915...

Seizing Teachable Moments to Develop Integrative Middle Level Curriculum

ERIC Educational Resources Information Center

Virtue, David C.

2007-01-01

September 11, 2001, was a critical teachable moment that provided the author of this article and his team with an avenue to middle level curriculum that was relevant, challenging, integrative, and exploratory. Hurricane Katrina opened a similar window of opportunity for middle level educators to focus the minds of young adolescents on important…

Can Universal, Place-Based Scholarships Reduce Inequality? Lessons from Kalamazoo, Michigan

ERIC Educational Resources Information Center

Miller-Adams, Michelle

2010-01-01

The Kalamazoo Promise, announced in 2005, is an innovative college-scholarship program available to every graduate of the Kalamazoo (Michigan) Public Schools. Programs such as the Kalamazoo Promise, which is being emulated in cities across the United States, open new avenues for the acquisition of human capital regardless of income level or…

78 FR 51100 - Appliance Standards and Rulemaking Federal Advisory Committee: Notice of Open Teleconference/Webinar

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... and Building Codes, U.S. Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy... posted at http://www1.eere.energy.gov/buildings/appliance_standards/asrac.html : Update on Commercial... Energy, Building Technologies Program, Mailstop EE-2J, 1000 Independence Avenue SW., Washington, DC 20585...

75 FR 57024 - Meeting of the Presidential Advisory Council on HIV/AIDS

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Meeting of the Presidential Advisory Council on HIV/AIDS... on HIV/AIDS (PACHA) will hold a meeting. The meeting will be open to the public. DATES: The meeting..., Presidential Advisory Council on HIV/AIDS, Department of Health and Human Services, 200 Independence Avenue, SW...

76 FR 27323 - Meeting of the Presidential Advisory Council on HIV/AIDS

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Meeting of the Presidential Advisory Council on HIV/AIDS... on HIV/AIDS (PACHA) will hold a meeting. The meeting will be open to the public. DATES: The meeting... Advisory Council on HIV/AIDS, Department of Health and Human Services, 200 Independence Avenue, Room 443H...

55. Aerial view looking north; end of openwater section of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

55. Aerial view looking north; end of open-water section of Dundee Canal at bottom, Botany Worsted Mills at center - Dundee Canal Industrial Historic District, Beginning at George Street in Passaic & extending north along Dundee Canal approximately 1.2 miles to Canal headgates opposite East Clifton Avenue in Clifton, Passaic, Passaic County, NJ

Proceedings of Naval Environmental Protection Data Base Instrumentation Workshop. Held at Channel Islands Harbor, California on 11-12 July 1972.

DTIC Science & Technology

with other activities measuring and monitoring environmental pollution , open and/or expand avenues of communication with other environmental activities...measuring and monitoring environmental pollution , and provide a vehicle for participants to review and update their current and future techniques and instrumentation needs.

Master-slave interferometry for parallel spectral domain interferometry sensing and versatile 3D optical coherence tomography.

PubMed

Podoleanu, Adrian Gh; Bradu, Adrian

2013-08-12

Conventional spectral domain interferometry (SDI) methods suffer from the need of data linearization. When applied to optical coherence tomography (OCT), conventional SDI methods are limited in their 3D capability, as they cannot deliver direct en-face cuts. Here we introduce a novel SDI method, which eliminates these disadvantages. We denote this method as Master - Slave Interferometry (MSI), because a signal is acquired by a slave interferometer for an optical path difference (OPD) value determined by a master interferometer. The MSI method radically changes the main building block of an SDI sensor and of a spectral domain OCT set-up. The serially provided signal in conventional technology is replaced by multiple signals, a signal for each OPD point in the object investigated. This opens novel avenues in parallel sensing and in parallelization of signal processing in 3D-OCT, with applications in high- resolution medical imaging and microscopy investigation of biosamples. Eliminating the need of linearization leads to lower cost OCT systems and opens potential avenues in increasing the speed of production of en-face OCT images in comparison with conventional SDI.

CRISPR/Cas9: From Genome Engineering to Cancer Drug Discovery

PubMed Central

Luo, Ji

2016-01-01

Advances in translational research are often driven by new technologies. The advent of microarrays, next-generation sequencing, proteomics and RNA interference (RNAi) have led to breakthroughs in our understanding of the mechanisms of cancer and the discovery of new cancer drug targets. The discovery of the bacterial clustered regularly interspaced palindromic repeat (CRISPR) system and its subsequent adaptation as a tool for mammalian genome engineering has opened up new avenues for functional genomics studies. This review will focus on the utility of CRISPR in the context of cancer drug target discovery. PMID:28603775

Self-assembled biomimetic nanoreactors I: Polymeric template

NASA Astrophysics Data System (ADS)

McTaggart, Matt; Malardier-Jugroot, Cecile; Jugroot, Manish

2015-09-01

The variety of nanoarchitectures made feasible by the self-assembly of alternating copolymers opens new avenues for biomimicry. Indeed, self-assembled structures allow the development of nanoreactors which combine the efficiency of high surface area metal active centres to the effect of confinement due to the very small cavities generated by the self-assembly process. A novel self-assembly of high molecular weight alternating copolymers is characterized in the present study. The self-assembly is shown to organize into nanosheets, providing a 2 nm hydrophobic cavity with a 1D confinement.

The GPlates Portal: Cloud-Based Interactive 3D Visualization of Global Geophysical and Geological Data in a Web Browser.

PubMed

Müller, R Dietmar; Qin, Xiaodong; Sandwell, David T; Dutkiewicz, Adriana; Williams, Simon E; Flament, Nicolas; Maus, Stefan; Seton, Maria

2016-01-01

The pace of scientific discovery is being transformed by the availability of 'big data' and open access, open source software tools. These innovations open up new avenues for how scientists communicate and share data and ideas with each other and with the general public. Here, we describe our efforts to bring to life our studies of the Earth system, both at present day and through deep geological time. The GPlates Portal (portal.gplates.org) is a gateway to a series of virtual globes based on the Cesium Javascript library. The portal allows fast interactive visualization of global geophysical and geological data sets, draped over digital terrain models. The globes use WebGL for hardware-accelerated graphics and are cross-platform and cross-browser compatible with complete camera control. The globes include a visualization of a high-resolution global digital elevation model and the vertical gradient of the global gravity field, highlighting small-scale seafloor fabric such as abyssal hills, fracture zones and seamounts in unprecedented detail. The portal also features globes portraying seafloor geology and a global data set of marine magnetic anomaly identifications. The portal is specifically designed to visualize models of the Earth through geological time. These space-time globes include tectonic reconstructions of the Earth's gravity and magnetic fields, and several models of long-wavelength surface dynamic topography through time, including the interactive plotting of vertical motion histories at selected locations. The globes put the on-the-fly visualization of massive data sets at the fingertips of end-users to stimulate teaching and learning and novel avenues of inquiry.

The GPlates Portal: Cloud-Based Interactive 3D Visualization of Global Geophysical and Geological Data in a Web Browser

PubMed Central

Müller, R. Dietmar; Qin, Xiaodong; Sandwell, David T.; Dutkiewicz, Adriana; Williams, Simon E.; Flament, Nicolas; Maus, Stefan; Seton, Maria

2016-01-01

The pace of scientific discovery is being transformed by the availability of ‘big data’ and open access, open source software tools. These innovations open up new avenues for how scientists communicate and share data and ideas with each other and with the general public. Here, we describe our efforts to bring to life our studies of the Earth system, both at present day and through deep geological time. The GPlates Portal (portal.gplates.org) is a gateway to a series of virtual globes based on the Cesium Javascript library. The portal allows fast interactive visualization of global geophysical and geological data sets, draped over digital terrain models. The globes use WebGL for hardware-accelerated graphics and are cross-platform and cross-browser compatible with complete camera control. The globes include a visualization of a high-resolution global digital elevation model and the vertical gradient of the global gravity field, highlighting small-scale seafloor fabric such as abyssal hills, fracture zones and seamounts in unprecedented detail. The portal also features globes portraying seafloor geology and a global data set of marine magnetic anomaly identifications. The portal is specifically designed to visualize models of the Earth through geological time. These space-time globes include tectonic reconstructions of the Earth’s gravity and magnetic fields, and several models of long-wavelength surface dynamic topography through time, including the interactive plotting of vertical motion histories at selected locations. The globes put the on-the-fly visualization of massive data sets at the fingertips of end-users to stimulate teaching and learning and novel avenues of inquiry. PMID:26960151

OpenHealth Platform for Interactive Contextualization of Population Health Open Data.

PubMed

Almeida, Jonas S; Hajagos, Janos; Crnosija, Ivan; Kurc, Tahsin; Saltz, Mary; Saltz, Joel

The financial incentives for data science applications leading to improved health outcomes, such as DSRIP (bit.ly/dsrip), are well-aligned with the broad adoption of Open Data by State and Federal agencies. This creates entirely novel opportunities for analytical applications that make exclusive use of the pervasive Web Computing platform. The framework described here explores this new avenue to contextualize Health data in a manner that relies exclusively on the native JavaScript interpreter and data processing resources of the ubiquitous Web Browser. The OpenHealth platform is made publicly available, and is publicly hosted with version control and open source, at https://github.com/mathbiol/openHealth. The different data/analytics workflow architectures explored are accompanied with live applications ranging from DSRIP, such as Hospital Inpatient Prevention Quality Indicators at http://bit.ly/pqiSuffolk, to The Cancer Genome Atlas (TCGA) as illustrated by http://bit.ly/tcgascopeGBM.

Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices

NASA Astrophysics Data System (ADS)

Varela, Juan A.; Dupuis, Julien P.; Etchepare, Laetitia; Espana, Agnès; Cognet, Laurent; Groc, Laurent

2016-03-01

Single-molecule imaging has changed the way we understand many biological mechanisms, particularly in neurobiology, by shedding light on intricate molecular events down to the nanoscale. However, current single-molecule studies in neuroscience have been limited to cultured neurons or organotypic slices, leaving as an open question the existence of fast receptor diffusion in intact brain tissue. Here, for the first time, we targeted dopamine receptors in vivo with functionalized quantum dots and were able to perform single-molecule tracking in acute rat brain slices. We propose a novel delocalized and non-inflammatory way of delivering nanoparticles (NPs) in vivo to the brain, which allowed us to label and track genetically engineered surface dopamine receptors in neocortical neurons, revealing inherent behaviour and receptor activity regulations. We thus propose a NP-based platform for single-molecule studies in the living brain, opening new avenues of research in physiological and pathological animal models.

Social Networking Web Sites: Teaching Appropriate Social Competence to Students with Emotional and Behavioral Disorders

ERIC Educational Resources Information Center

Morgan, Joseph J.

2010-01-01

The Internet has opened a variety of different avenues for people to interact with each other. As new digital environments are developed, new sets of social skills are needed to appropriately interact. Students with emotional and behavioral disorders often have deficits in social competence and require specialized training in specific social…

33 CFR 117.291 - Hillsborough River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... drawspans for the drawbridges at Platt Street, mile 0.0, Brorein Street, mile 0.16, Kennedy Boulevard, mile 0.4, Cass Street, mile 0.7, Laurel Street, mile 1.0, West Columbus Drive, mile 2.3, and West Hillsborough Avenue, mile 4.8, must open on signal if at least two hours notice is given; except that, the...

33 CFR 117.291 - Hillsborough River.

Code of Federal Regulations, 2012 CFR

2012-07-01

... drawspans for the drawbridges at Platt Street, mile 0.0, Brorein Street, mile 0.16, Kennedy Boulevard, mile 0.4, Cass Street, mile 0.7, Laurel Street, mile 1.0, West Columbus Drive, mile 2.3, and West Hillsborough Avenue, mile 4.8, must open on signal if at least two hours notice is given; except that, the...

33 CFR 117.291 - Hillsborough River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... drawspans for the drawbridges at Platt Street, mile 0.0, Brorein Street, mile 0.16, Kennedy Boulevard, mile 0.4, Cass Street, mile 0.7, Laurel Street, mile 1.0, West Columbus Drive, mile 2.3, and West Hillsborough Avenue, mile 4.8, must open on signal if at least two hours notice is given; except that, the...

33 CFR 117.291 - Hillsborough River.

Code of Federal Regulations, 2013 CFR

2013-07-01

... drawspans for the drawbridges at Platt Street, mile 0.0, Brorein Street, mile 0.16, Kennedy Boulevard, mile 0.4, Cass Street, mile 0.7, Laurel Street, mile 1.0, West Columbus Drive, mile 2.3, and West Hillsborough Avenue, mile 4.8, must open on signal if at least two hours notice is given; except that, the...

33 CFR 117.291 - Hillsborough River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... drawspans for the drawbridges at Platt Street, mile 0.0, Brorein Street, mile 0.16, Kennedy Boulevard, mile 0.4, Cass Street, mile 0.7, Laurel Street, mile 1.0, West Columbus Drive, mile 2.3, and West Hillsborough Avenue, mile 4.8, must open on signal if at least two hours notice is given; except that, the...

Neutrino phenomenology

DOE PAGES

Coloma, Pilar

2016-11-21

Neutrino oscillations have demonstrated that neutrinos have mass and, by now, oscillation experiments have been able to determine most of the parameters in the leptonic mixing matrix with a very good accuracy. Nevertheless, there are still many open questions in the neutrino sector. As a result, I will briefly discuss some of these questions, pointing out possible experimental avenues to address them.

"Her Soul beneath the Bone"--On Coping with Breast Cancer.

ERIC Educational Resources Information Center

Jacoby, Rebecca

2003-01-01

Common approaches to coping are discussed, followed by a description of the process of women coping with breast cancer as it is expressed in their own poems. Qualitative analysis was conducted on eight poems, with the results opening new avenues for counselors who work with women suffering from breast cancer. (Contains 54 references.) (GCP)

Big Data: Laying the Groundwork. ECAR Working Group Paper

ERIC Educational Resources Information Center

Almes, Guy T.; Hillegas, Curtis W.; Lance, Timothy; Lynch, Clifford A.; Monaco, Gregory E.; Mundrane, Michael R.; Zottola, Ralph J.

2014-01-01

This paper is part of series of the EDUCAUSE Center for Analysis and Research Campus Cyberinfrastructure (ECAR-CCI) Working Group. The topic of big data continues to receive a great deal of publicity because of its promise for opening new avenues of scholarly discovery and commercial opportunity. The ability to sift rapidly through massive amounts…

Big Data in the Campus Landscape: Curation. ECAR Working Group Paper

ERIC Educational Resources Information Center

Lynch, Clifford A.

2015-01-01

This paper is part of series of the EDUCAUSE Center for Analysis and Research Campus Cyberinfrastructure (ECAR-CCI) Working Group. The topic of big data continues to receive a great deal of publicity because of its promise for opening new avenues of scholarly discovery and commercial opportunity. The ability to sift rapidly through massive amounts…

78 FR 13645 - Notice of Public Meetings for the Draft Environmental Impact Statement and Draft Clean Air Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... Conformity Determination in an open house format. DoN representatives will be available at informational... Determination are available for public review at the following libraries: 1. City of El Centro Public Library, 1140 North Imperial Avenue, El Centro, California 92243. 2. City of Imperial Public Library, 200 West...

77 FR 55195 - Notice of Public Meetings for the Draft Environmental Impact Statement for Naval Weapons Systems...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-07

... the analysis in the Draft EIS. Each of the public meetings will include an open house information... review at the following public libraries: 1. Multnomah County Central Library, 801 Southwest 10th Avenue, Portland, Oregon 97205. 2. Boardman Branch of the Oregon Trail Library District, 200 South Main Street...

76 FR 17157 - Notice of an Open Meeting of the Advisory Committee on Apprenticeship (ACA)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-28

...: Announcement of meeting. SUMMARY: Pursuant to section 10 of the Federal Advisory Committee Act (Pub. L. 92-463... the provisions of the Federal Advisory Committee Act (FACA), as amended 5 U.S.C., App. 2, and it's... location is the U.S. Department of Labor, Frances Perkins Building, 200 Constitution Avenue, NW...

Detail section extending from shore. Note the paired support pilings, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail section extending from shore. Note the paired support pilings, concrete curbs with rectangular openings for drainage, and large-diameter metal pipe suspended under the deck. USS MISSOURI in background - U.S. Naval Base, Pearl Harbor, Gasoline Wharf, Offshore, near the intersection of Hornet Avenue & Curtis Street, Ford Island, Pearl City, Honolulu County, HI

77 FR 14591 - Open Meeting of the Federal Advisory Committee on Insurance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... Avenue NW., Washington, DC 20220, at (202) 622-6910 (this is not a toll-free number). Persons who have difficulty hearing or speaking may access this number via TTY by calling the toll-free Federal Relay Service... on the work to date of the Federal Insurance Office. Lance Auer, Deputy Assistant Secretary Financial...

78 FR 42820 - Agency Information Collection (Caution to Bidders-Bid Envelopes) Activities Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... or a Copy of the Submission Contact: Crystal Rennie, Enterprise Records Service (005R1B), Department of Veterans Affairs, 810 Vermont Avenue NW., Washington, DC 20420, (202) 632-7492 or email: crystal... mail or packages received and to ensure the bids are delivered to the proper bid opening room on time...

INTERIOR VIEW, WEST WALL OF NORTHWEST ATTIC CHAMBER. THIS SPACIOUS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR VIEW, WEST WALL OF NORTHWEST ATTIC CHAMBER. THIS SPACIOUS ROOM INCLUDED A ROOF MONITOR FOR LIGHT AND VENTILATION AND A FIREPLACE FOR HEAT. THE WALL OPENING AND DOOR ON EITHER SIDE OF THE FIREPLACE GIVE ONTO A LARGE UNFINISHED SPACE LOCATED OVER THE HOUSE’S WEST WING - The Woodlands, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

Validating the Novel Method of Measuring Cortisol Levels in Cetacean Skin by use of an ACTH Challenge in Bottlenose Dolphins

DTIC Science & Technology

2014-09-30

hours, in addition to other manipulations (e.g. blubber biopsies). This process has shown to significantly raise both cortisol and aldosterone above...cetacean skin samples will bring new possibilities for stress assessment in cetaceans, opening up a new avenue of research in physiological response

Can the American High School become an Avenue of Advancement for All?

ERIC Educational Resources Information Center

Balfanz, Robert

2009-01-01

As the twenty-first century opens, says Robert Balfanz, the United States is developing a deep social consensus that American high schools should ensure that all adolescents graduate from high school prepared for postsecondary schooling and training. Balfanz asks how well high schools are succeeding in this mission and whether they can ultimately…

77 FR 37901 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-25

... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Flexible Polyurethane Foam... Constitution Avenue NW., Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4... Flexible Polyurethane Foam Fabrication (Renewal). ICR Numbers: EPA ICR Number 2027.05, OMB Control Number...

76 FR 68203 - Mechanisms of Compliance with United States Citizenship Requirements for the Ownership of Vessels...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-03

... Transportation, West Building Ground Floor, Room W12-140, 1200 New Jersey Avenue SE., Washington, DC 20590-0001... or privileged or confidential information, or be detrimental to the security of transportation. The... the ``Open Docket Folder'' in the ``Actions'' column. If you do not have access to the internet, you...

77 FR 6557 - Agency Information Collection Activities: Request for Comments on One Proposed Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-08

... Compliance Docket and Information Center (ECDIC), in the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Avenue NW., Washington, DC. The EPA/DC Public Reading Room is open from 8 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The telephone number for the Reading Room...

Evidence of a Critical Phase Transition in Purely Temporal Dynamics with Long-Delayed Feedback

NASA Astrophysics Data System (ADS)

Faggian, Marco; Ginelli, Francesco; Marino, Francesco; Giacomelli, Giovanni

2018-04-01

Experimental evidence of an absorbing phase transition, so far associated with spatiotemporal dynamics, is provided in a purely temporal optical system. A bistable semiconductor laser, with long-delayed optoelectronic feedback and multiplicative noise, shows the peculiar features of a critical phenomenon belonging to the directed percolation universality class. The numerical study of a simple, effective model provides accurate estimates of the transition critical exponents, in agreement with both theory and our experiment. This result pushes forward a hard equivalence of nontrivial stochastic, long-delayed systems with spatiotemporal ones and opens a new avenue for studying out-of-equilibrium universality classes in purely temporal dynamics.

Exploiting Molecular and Immune Biology of Gastric and Gastroesophageal Adenocarcinomas to Discover Novel Therapeutic Targets.

PubMed

Elimova, Elena; Song, Shumei; Shimodaira, Yusuke; Lin, Quan; Ajani, Jaffer A

2016-11-01

Gastroesophageal carcinomas (GACs) are a significant problem worldwide, and despite many attempts to improve the outcomes of patients with these tumors, little progress has been made over the last several decades. In the past decade, only transtuzumab and ramucirumab, two drugs with marginal clinical benefit, have been approved for the treatment of patients with GACs. After second-line therapy, most treatment options are generally ineffective. Prior studies in this disease have been largely empiric, using unselected patient populations. More recently, detailed somatic genotyping, enrichment of patients based on biomarkers, and pharmacokinetic studies have opened new avenues for developing treatment options in patients with GAC.

Brookland Site Development Study, Brookland, bounded by B&O Railroad Tracks, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Brookland Site Development Study, Brookland, bounded by B&O Railroad Tracks, Rhode Island & Brentwood Avenues on the south, 18th Street & South Dakota Avenue on the east, and Michigan Avenue on the North, Washington, District of Columbia, DC

Obligate intracellular bacterium Ehrlichia inhibiting mitochondrial activity

PubMed Central

Liu, Yan; Zhang, Zhikai; Jiang, Yongquan; Zhang, Lihong; Popov, Vsevolod L.; Zhang, Jianzhi; Walker, David H.; Yu, Xue-jie

2010-01-01

Ehrlichia are obligately intracellular bacteria that reside in a vacuole in the cytoplasm of phagocytes. We determined by confocal microscopy the interaction between Ehrlichia and mitochondria in DH82 cells to investigate the mechanism of Ehrlichia survival inside the phagocyte. The most remarkable finding of our study was that Ehrlichia morulae interacted with mitochondria and inhibited mitochondrial metabolism,. We showed that in E. chaffeensis-infected DH82 cells, mitochondria did not incorporate BrdU and transcriptional level of the mitochondrial gene NADPH2 was significantly reduced, indicating the inhibition of mitochondrial metabolism. This study demonstrates that Ehrlichia are able to inhibit mitochondrial activities, and it opens up a new avenue for the study of Ehrlichia pathogenesis. PMID:21070861

Pharmacological Enhancement of Memory and Executive Functioning in Laboratory Animals

PubMed Central

Floresco, Stan B; Jentsch, James D

2011-01-01

Investigating how different pharmacological compounds may enhance learning, memory, and higher-order cognitive functions in laboratory animals is the first critical step toward the development of cognitive enhancers that may be used to ameliorate impairments in these functions in patients suffering from neuropsychiatric disorders. Rather than focus on one aspect of cognition, or class of drug, in this review we provide a broad overview of how distinct classes of pharmacological compounds may enhance different types of memory and executive functioning, particularly those mediated by the prefrontal cortex. These include recognition memory, attention, working memory, and different components of behavioral flexibility. A key emphasis is placed on comparing and contrasting the effects of certain drugs on different cognitive and mnemonic functions, highlighting methodological issues associated with this type of research, tasks used to investigate these functions, and avenues for future research. Viewed collectively, studies of the neuropharmacological basis of cognition in rodents and non-human primates have identified targets that will hopefully open new avenues for the treatment of cognitive disabilities in persons affected by mental disorders. PMID:20844477

Gene networks and developmental context: the importance of understanding complex gene expression patterns in evolution.

PubMed

Signor, Sarah A; Arbeitman, Michelle N; Nuzhdin, Sergey V

2016-05-01

Animal development is the product of distinct components and interactions-genes, regulatory networks, and cells-and it exhibits emergent properties that cannot be inferred from the components in isolation. Often the focus is on the genotype-to-phenotype map, overlooking the process of development that turns one into the other. We propose a move toward micro-evolutionary analysis of development, incorporating new tools that enable cell type resolution and single-cell microscopy. Using the sex determination pathway in Drosophila to illustrate potential avenues of research, we highlight some of the questions that these emerging technologies can address. For example, they provide an unprecedented opportunity to study heterogeneity within cell populations, and the potential to add the dimension of time to gene regulatory network analysis. Challenges still remain in developing methods to analyze this data and to increase the throughput. However this line of research has the potential to bridge the gaps between previously more disparate fields, such as population genetics and development, opening up new avenues of research. © 2016 Wiley Periodicals, Inc.

Electron anions and the glass transition temperature.

PubMed

Johnson, Lewis E; Sushko, Peter V; Tomota, Yudai; Hosono, Hideo

2016-09-06

Properties of glasses are typically controlled by judicious selection of the glass-forming and glass-modifying constituents. Through an experimental and computational study of the crystalline, molten, and amorphous [Ca12Al14O32](2+) ⋅ (e(-))2, we demonstrate that electron anions in this system behave as glass modifiers that strongly affect solidification dynamics, the glass transition temperature, and spectroscopic properties of the resultant amorphous material. The concentration of such electron anions is a consequential control parameter: It invokes materials evolution pathways and properties not available in conventional glasses, which opens a unique avenue in rational materials design.

SiO Masers in Mira with ALMA Long Baselines

NASA Astrophysics Data System (ADS)

Humphreys, Elizabeth

2018-04-01

The effect of binary companions on the near-circumstellar environment of AGB stars is an open-question. Using ALMA long baseline data, we have investigated this region of Mira A using SiO emission. The data locate SiO masers with respect to the star, unlike lower frequency observations. They also indicate an impact of the binary companion on gas within about 10 Rstar of Mira A. These types of studies, using high-frequency SiO masers, can provide a new avenue for understanding the influence of binaries on AGB mass loss and envelope-shaping.

Electron anions and the glass transition temperature

DOE PAGES

Johnson, Lewis E.; Sushko, Peter V.; Tomota, Yudai; ...

2016-08-24

Properties of glasses are typically controlled by judicious selection of the glass-forming and glass-modifying constituents. Through an experimental and computational study of the crystalline, molten, and amorphous [Ca 12Al 14O 32] 2+ ∙ (e –) 2, we demonstrate that electron anions in this system behave as glass-modifiers that strongly affect solidification dynamics, the glass transition temperature, and spectroscopic properties of the resultant amorphous material. Concentration of such electron anions is a consequential control parameter: it invokes materials evolution pathways and properties not available in conventional glasses, which opens a new avenue in rational materials design.

Fabrication of Nanoscale Circuits on Inkjet-Printing Patterned Substrates.

PubMed

Chen, Shuoran; Su, Meng; Zhang, Cong; Gao, Meng; Bao, Bin; Yang, Qiang; Su, Bin; Song, Yanlin

2015-07-08

Nanoscale circuits are fabricated by assembling different conducting materials (e.g., metal nanoparticles, metal nano-wires, graphene, carbon nanotubes, and conducting polymers) on inkjet-printing patterned substrates. This non-litho-graphy strategy opens a new avenue for integrating conducting building blocks into nanoscale devices in a cost-efficient manner. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Digital Humanities: Envisioning a Collaborative Tool for Mapping, Evaluating, and Sharing Reconstructed Colonial American Parcel Maps

ERIC Educational Resources Information Center

Ruvane, Mary Brent

2012-01-01

The use of GIS technology for the humanities has opened up new avenues for visually exploring and asking questions of our nation's historical record. The potential to harness new knowledge with tools designed to capture and preserve geographic links to the artifacts of our past is within our grasp. This research explores the common information…

The Five-String Banjo in the Music Classroom

ERIC Educational Resources Information Center

Smith, Kenneth H.

2011-01-01

The banjo is an instrument of unique image and sound. It has a long history in North America from its arrival on slave ships from North Africa to its contemporary use in jazz and popular music. Adding the instrument to the general music classroom can open new realms of timbre and new avenues of exploration into the instruments of cultures around…

Big Data in the Campus Landscape: Basic Infrastructure Support. ECAR Working Group Paper

ERIC Educational Resources Information Center

Almes, Guy T.; Zottola, Ralph J.

2014-01-01

This paper is part of series of the EDUCAUSE Center for Analysis and Research Campus Cyberinfrastructure (ECAR-CCI) Working Group. The topic of big data continues to receive a great deal of publicity because of its promise for opening new avenues of scholarly discovery and commercial opportunity. The ability to sift rapidly through massive amounts…

77 FR 74000 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-12

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Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

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Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

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Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-20

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Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

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Big Data in the Campus Landscape: Security and Privacy. ECAR Working Group Paper

ERIC Educational Resources Information Center

Barnett, William; Corn, Mike; Hillegas, Curt; Wada, Kent

2015-01-01

This paper is part of series of the EDUCAUSE Center for Analysis and Research Campus Cyberinfrastructure (ECAR-CCI) Working Group. The topic of big data continues to receive a great deal of publicity because of its promise for opening new avenues of scholarly discovery and commercial opportunity. The ability to sift rapidly through massive amounts…

Thermochromic Artificial Nacre Based on Montmorillonite.

PubMed

Peng, Jingsong; Cheng, Yiren; Tomsia, Antoni P; Jiang, Lei; Cheng, Qunfeng

2017-07-26

Nacre-inspired nanocomposites have attracted a great deal of attention in recent years because of their special mechanical properties and universality of the underlying principles of materials engineering. The ability to respond to external stimuli will augment the high toughness and high strength of artificial nacre-like composites and open new technological horizons for these materials. Herein, we fabricated robust artificial nacre based on montmorillonite (MMT) that combines robustness with reversible thermochromism. Our artificial nacre shows great potential in various fields such as aerospace and sensors and opens an avenue to fabricate artificial nacre responsive to other external stimuli in the future.

Why and How Political Science Can Contribute to Public Health? Proposals for Collaborative Research Avenues.

PubMed

Gagnon, France; Bergeron, Pierre; Clavier, Carole; Fafard, Patrick; Martin, Elisabeth; Blouin, Chantal

2017-04-05

Written by a group of political science researchers, this commentary focuses on the contributions of political science to public health and proposes research avenues to increase those contributions. Despite progress, the links between researchers from these two fields develop only slowly. Divergences between the approach of political science to public policy and the expectations that public health can have about the role of political science, are often seen as an obstacle to collaboration between experts in these two areas. Thus, promising and practical research avenues are proposed along with strategies to strengthen and develop them. Considering the interdisciplinary and intersectoral nature of population health, it is important to create a critical mass of researchers interested in the health of populations and in healthy public policy that can thrive working at the junction of political science and public health. © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Strategic Technologies for Deep Space Transport

NASA Technical Reports Server (NTRS)

Litchford, Ronald J.

2016-01-01

Deep space transportation capability for science and exploration is fundamentally limited by available propulsion technologies. Traditional chemical systems are performance plateaued and require enormous Initial Mass in Low Earth Orbit (IMLEO) whereas solar electric propulsion systems are power limited and unable to execute rapid transits. Nuclear based propulsion and alternative energetic methods, on the other hand, represent potential avenues, perhaps the only viable avenues, to high specific power space transport evincing reduced trip time, reduced IMLEO, and expanded deep space reach. Here, key deep space transport mission capability objectives are reviewed in relation to STMD technology portfolio needs, and the advanced propulsion technology solution landscape is examined including open questions, technical challenges, and developmental prospects. Options for potential future investment across the full compliment of STMD programs are presented based on an informed awareness of complimentary activities in industry, academia, OGAs, and NASA mission directorates.

Perspectives on biological growth and remodeling

PubMed Central

Ambrosi, D.; Ateshian, G. A.; Arruda, E. M.; Cowin, S. C.; Dumais, J.; Goriely, A.; Holzapfel, G. A.; Humphrey, J. D.; Kemkemer, R.; Kuhl, E.; Olberding, J. E.; Taber, L. A.; Garikipati, K.

2011-01-01

The continuum mechanical treatment of biological growth and remodeling has attracted considerable attention over the past fifteen years. Many aspects of these problems are now well-understood, yet there remain areas in need of significant development from the standpoint of experiments, theory, and computation. In this perspective paper we review the state of the field and highlight open questions, challenges, and avenues for further development. PMID:21532929

Flying podocytes.

PubMed

Simons, Matias; Huber, Tobias B

2009-03-01

Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocytes, including the nephrin-based slit diaphragm. This novel podocyte system might open new avenues toward the understanding of podocyte biology and pathophysiology.

From nurse to marketing entrepreneur.

PubMed

Aydlotte, J H

1998-03-01

An important lesson in career advancement is to be prepared for and take advantage of sudden opportunities that come your way. This risk-taking nurse went into nurse recruitment, which then opened avenues into health care marketing. She pioneered one of the largest health care advertising companies in the country and describes how she has used her new-found skills, at work and at home, to face life's biggest challenges.

78 FR 36777 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... either public viewing online at http://www.regulations.gov , or in person viewing at the Enforcement and Compliance Docket in the EPA Docket Center (EPA/ DC), EPA West, Room 3334, 1301 Constitution Avenue NW, Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through...

What is Intrinsic Motivation? A Typology of Computational Approaches

PubMed Central

Oudeyer, Pierre-Yves; Kaplan, Frederic

2007-01-01

Intrinsic motivation, centrally involved in spontaneous exploration and curiosity, is a crucial concept in developmental psychology. It has been argued to be a crucial mechanism for open-ended cognitive development in humans, and as such has gathered a growing interest from developmental roboticists in the recent years. The goal of this paper is threefold. First, it provides a synthesis of the different approaches of intrinsic motivation in psychology. Second, by interpreting these approaches in a computational reinforcement learning framework, we argue that they are not operational and even sometimes inconsistent. Third, we set the ground for a systematic operational study of intrinsic motivation by presenting a formal typology of possible computational approaches. This typology is partly based on existing computational models, but also presents new ways of conceptualizing intrinsic motivation. We argue that this kind of computational typology might be useful for opening new avenues for research both in psychology and developmental robotics. PMID:18958277

A Case for Pharmacogenomics in Management of Cardiac Arrhythmias

PubMed Central

Kandoi, Gaurav; Nanda, Anjali; Scaria, Vinod; Sivasubbu, Sridhar

2012-01-01

Disorders of the cardiac rhythm are quite prevalent in clinical practice. Though the variability in drug response between individuals has been extensively studied, this information has not been widely used in clinical practice. Rapid advances in the field of pharmacogenomics have provided us with crucial insights on inter-individual genetic variability and its impact on drug metabolism and action. Technologies for faster and cheaper genetic testing and even personal genome sequencing would enable clinicians to optimize prescription based on the genetic makeup of the individual, which would open up new avenues in the area of personalized medicine. We have systematically looked at literature evidence on pharmacogenomics markers for anti-arrhythmic agents from the OpenPGx consortium collection and reason the applicability of genetics in the management of arrhythmia. We also discuss potential issues that need to be resolved before personalized pharmacogenomics becomes a reality in regular clinical practice. PMID:22557843

Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator.

PubMed

Zhang, Zhe; Chen, Jue

2016-12-01

The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel evolved from the ATP-binding cassette (ABC) transporter family. In this study, we determined the structure of zebrafish CFTR in the absence of ATP by electron cryo-microscopy to 3.7 Å resolution. Human and zebrafish CFTR share 55% sequence identity, and 42 of the 46 cystic-fibrosis-causing missense mutational sites are identical. In CFTR, we observe a large anion conduction pathway lined by numerous positively charged residues. A single gate near the extracellular surface closes the channel. The regulatory domain, dephosphorylated, is located in the intracellular opening between the two nucleotide-binding domains (NBDs), preventing NBD dimerization and channel opening. The structure also reveals why many cystic-fibrosis-causing mutations would lead to defects either in folding, ion conduction, or gating and suggests new avenues for therapeutic intervention. Copyright © 2016 Elsevier Inc. All rights reserved.

UV plasmonic device for sensing ethanol and acetone

NASA Astrophysics Data System (ADS)

Honda, Mitsuhiro; Ichikawa, Yo; Rozhin, Alex G.; Kulinich, Sergei A.

2018-01-01

In the present study, we demonstrate efficient detection of volatile organic vapors with improved sensitivity, exploiting the localized surface plasmon resonance of indium nanograins in the UV range (UV-LSPR). The sensitivity of deep-UV-LSPR measurements toward ethanol was observed to be 0.004 nm/ppm, which is 10 times higher than that of a previously reported visible-LSPR device based on Ag nanoprisms [Sensors 11, 8643 (2011)]. Although practical issues such as improving detection limits are still remaining, the results of the present study suggest that the new approach based on UV-LSPR may open new avenues to the detection of organic molecules in solid, liquid, and gas phases using plasmonic sensors.

Open access behaviours and perceptions of health sciences faculty and roles of information professionals.

PubMed

Lwoga, Edda T; Questier, Frederik

2015-03-01

This study sought to investigate the faculty's awareness, attitudes and use of open access, and the role of information professionals in supporting open access (OA) scholarly communication in Tanzanian health sciences universities. A cross-sectional survey was conducted. Semi-structured interviews were conducted with 16 librarians, while questionnaires were physically distributed to 415 faculty members in all eight Tanzanian health sciences universities, with a response rate of 71.1%. The study found that most faculty members were aware about OA issues. However, the high level of OA awareness among faculty members did not translate into actual dissemination of faculty's research outputs through OA web avenues. A small proportion of faculty's research materials was made available as OA. Faculty were more engaged with OA journal publishing than with self-archiving practices. Senior faculty with proficient technical skills were more likely to use open access than junior faculty. Major barriers to OA usage were related to ICT infrastructure, awareness, skills, author-pay model, and copyright and plagiarism concerns. Interviews with librarians revealed that there was a strong support for promoting OA issues on campus; however, this positive support with various open access-related tasks did not translate into actual action. It is thus important for librarians and OA administrators to consider all these factors for effective implementation of OA projects in research and academic institutions. This is the first comprehensive and detailed study focusing on the health sciences faculty's and librarians' behaviours and perceptions of open access initiatives in Tanzania and reveals findings that are useful for planning and implementing open access initiatives in other institutions with similar conditions. © 2015 Health Libraries Journal.

Commentary: The Materials Project: A materials genome approach to accelerating materials innovation

NASA Astrophysics Data System (ADS)

Jain, Anubhav; Ong, Shyue Ping; Hautier, Geoffroy; Chen, Wei; Richards, William Davidson; Dacek, Stephen; Cholia, Shreyas; Gunter, Dan; Skinner, David; Ceder, Gerbrand; Persson, Kristin A.

2013-07-01

Accelerating the discovery of advanced materials is essential for human welfare and sustainable, clean energy. In this paper, we introduce the Materials Project (www.materialsproject.org), a core program of the Materials Genome Initiative that uses high-throughput computing to uncover the properties of all known inorganic materials. This open dataset can be accessed through multiple channels for both interactive exploration and data mining. The Materials Project also seeks to create open-source platforms for developing robust, sophisticated materials analyses. Future efforts will enable users to perform ``rapid-prototyping'' of new materials in silico, and provide researchers with new avenues for cost-effective, data-driven materials design.

Crossed Ga2O3/SnO2 multiwire architecture: a local structure study with nanometer resolution.

PubMed

Martínez-Criado, Gema; Segura-Ruiz, Jaime; Chu, Manh-Hung; Tucoulou, Remi; López, Iñaki; Nogales, Emilio; Mendez, Bianchi; Piqueras, Javier

2014-10-08

Crossed nanowire structures are the basis for high-density integration of a variety of nanodevices. Owing to the critical role of nanowires intersections in creating hybrid architectures, it has become a challenge to investigate the local structure in crossing points in metal oxide nanowires. Thus, if intentionally grown crossed nanowires are well-patterned, an ideal model to study the junction is formed. By combining electron and synchrotron beam nanoprobes, we show here experimental evidence of the role of impurities in the coupling formation, structural modifications, and atomic site configuration based on crossed Ga2O3/SnO2 nanowires. Our experiment opens new avenues for further local structure studies with both nanometer resolution and elemental sensitivity.

Exosomes released by keratinocytes modulate melanocyte pigmentation

PubMed Central

Cicero, Alessandra Lo; Delevoye, Cédric; Gilles-Marsens, Floriane; Loew, Damarys; Dingli, Florent; Guéré, Christelle; André, Nathalie; Vié, Katell; van Niel, Guillaume; Raposo, Graça

2015-01-01

Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is regulated by intercellular communication in both healthy and diseased states. PMID:26103923

Single-Molecule Imaging of RNA Splicing in Live Cells.

PubMed

Rino, José; Martin, Robert M; Carvalho, Célia; de Jesus, Ana C; Carmo-Fonseca, Maria

2015-01-01

Expression of genetic information in eukaryotes involves a series of interconnected processes that ultimately determine the quality and amount of proteins in the cell. Many individual steps in gene expression are kinetically coupled, but tools are lacking to determine how temporal relationships between chemical reactions contribute to the output of the final gene product. Here, we describe a strategy that permits direct measurements of intron dynamics in single pre-mRNA molecules in live cells. This approach reveals that splicing can occur much faster than previously proposed and opens new avenues for studying how kinetic mechanisms impact on RNA biogenesis. © 2015 Elsevier Inc. All rights reserved.

Carrier-doped aromatic hydrocarbons: a new platform in condensed matter chemistry and physics.

PubMed

Heguri, Satoshi; Tanigaki, Katsumi

2018-02-27

High-quality bulk samples of the first four polyacenes, which are naphthalene, anthracene, tetracene, and pentacene, doped with alkali metal in 1 : 1 and 1 : 2 stoichiometries were prepared and their fundamental properties were systematically studied. A new systematic understanding on the electronic states of electron-doped polyacenes sensitive to the energetic balance among on-site Coulomb repulsion, bandwidth and the Peierls instability was provided. The carrier-doped typical aromatic hydrocarbons showed a large variety of properties as well as charge transfer complexes and metal-doped fullerides. We open a new avenue for organometallic and inorganic chemistry.

The Most Massive Heartbeat: Finding the Pulse of ι Orionis

NASA Astrophysics Data System (ADS)

Pablo, Herbert; Richardson, Noel; Fuller, Jim; Moffat, Anthony F. J.; BEST and Ritter Observing Team

2017-11-01

ι Orionis is a massive binary system consisting of O9III + B1 III/IV stars. Though the system has been well studied, much about its fundamental properties have been difficult to determine. In this paper we report on the discovery of the heartbeat phenomenon in ι Orionis making it the most massive heartbeat system currently known. Using this phenomenon we have found empirical values for the masses and radii of both components. Moreover, we report the detection of tidally induced oscillations in an O-type star for the first time. These discoveries open a new avenue for exploring asteroseismology in massive stars.

A New Era for Jefferson Lab

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKeown, R. D.; Montgomery, H. E.; Pennington, M. R.

On a cool Saturday morning in late April a seemingly endless stream of cars turned off Jefferson Avenue in Newport News, Virginia, bringing 12,000 people ages 1 to 91 to the Open House to learn more about “the new era in science” at the Thomas Jefferson National Accelerator Facility. Here, the visitors were dazzled by the complex equipment, the enthusiastic staff, and the advanced technology at the Laboratory.

A detachable ester bond enables perfect Z-alkylations of olefins for the synthesis of tri- and tetrasubstituted alkenes.

PubMed

Nishikata, Takashi; Nakamura, Kimiaki; Inoue, Yuki; Ishikawa, Shingo

2015-06-25

2-Vinyl-substituted phenol and an alpha-bromoester undergo a tandem esterification-alkylation reaction in the presence of a Cu-amine catalyst system to produce benzene-fused lactone. Z-Alkylated styrene is obtained after hydrolysis of the lactone with perfect selectivity. The simple protocol developed in this work opens a new avenue in the multi-substitution chemistry of alkenes.

Pathological-Condition-Driven Construction of Supramolecular Nanoassemblies for Bacterial Infection Detection.

PubMed

Li, Li-Li; Ma, Huai-Lei; Qi, Guo-Bin; Zhang, Di; Yu, Faquan; Hu, Zhiyuan; Wang, Hao

2016-01-13

A pyropheophorbide-α-based building block (Ppa-PLGVRG-Van) can be used to construct self-aggregated superstructures in vivo for highly specific and sensitive diagnosis of bacterial infection by noninvasive photoacoustic tomography. This in vivo supramolecular chemistry approach opens a new avenue for efficient, rapid, and early-stage disease diagnosis with high sensitivity and specificity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

New Eye-Tracking Techniques May Revolutionize Mental Health Screening

DTIC Science & Technology

2015-11-04

health? Recent progress in eye-tracking tech- niques is opening new avenues for quanti - tative, objective, simple, inexpensive, and rapid evaluation ...to check with your doctor whether any corrective action should be taken. What if similar devices could be made available for the evaluation of mental... evaluations , especially for those disor- ders for which a clear chemical, genetic, morphological, physiological, or histologi- cal biomarker has not yet

Metal-free bioconjugation reactions.

PubMed

van Berkel, Sander S; van Delft, Floris L

2013-01-01

The recent strategy to apply chemical reactions to address fundamental biological questions has led to the emergence of entirely new conjugation reactions that are fast and irreversible, yet so mild and selective that they can be performed even in living cells or organisms. These so-called bioorthogonal reactions open novel avenues, not only in chemical biology research, but also in many other life sciences applications, including the modulation of biopharmaceuticals by site-specific modification approaches.

A New Era for Jefferson Lab

DOE PAGES

McKeown, R. D.; Montgomery, H. E.; Pennington, M. R.

2016-09-16

On a cool Saturday morning in late April a seemingly endless stream of cars turned off Jefferson Avenue in Newport News, Virginia, bringing 12,000 people ages 1 to 91 to the Open House to learn more about “the new era in science” at the Thomas Jefferson National Accelerator Facility. Here, the visitors were dazzled by the complex equipment, the enthusiastic staff, and the advanced technology at the Laboratory.

Studies of vesicle distribution patterns in Hawaiian lavas

NASA Technical Reports Server (NTRS)

Walker, George P. L.

1987-01-01

Basaltic lava flows are generally vesicular, and the broader facts relating to vesicle distribution have long been established; few studies have yet been made with a view to determining how and when vesicles form in the cooling history of the lava, explaining vesicle shape and size distribution, and gaining enough understanding to employ vesicles as a geological tool. Various avenues of approach exist by which one may seek to gain a better understanding of these ubiquitous structures and make a start towards developing a general theory, and three such avenues have recently been explored. One avenue involves the study of pipe vesicles; these are a well known feature of lava flows and are narrow pipes which occur near the base of many pahoehoe flow units. Another avenue of approach is that presented by the distinctive spongy pahoehoe facies of lava that is common in distal locations on Hawaiian volcanoes. A third avenue of approach is that of the study of gas blisters in lava. Gas blisters are voids, which can be as much as tens of meters wide, where the lava split along a vesicle-rich layer and the roof up-arched by gas pressure. These three avenues are briefly discussed.

Biosensors with Built-In Biomolecular Logic Gates for Practical Applications

PubMed Central

Lai, Yu-Hsuan; Sun, Sin-Cih; Chuang, Min-Chieh

2014-01-01

Molecular logic gates, designs constructed with biological and chemical molecules, have emerged as an alternative computing approach to silicon-based logic operations. These molecular computers are capable of receiving and integrating multiple stimuli of biochemical significance to generate a definitive output, opening a new research avenue to advanced diagnostics and therapeutics which demand handling of complex factors and precise control. In molecularly gated devices, Boolean logic computations can be activated by specific inputs and accurately processed via bio-recognition, bio-catalysis, and selective chemical reactions. In this review, we survey recent advances of the molecular logic approaches to practical applications of biosensors, including designs constructed with proteins, enzymes, nucleic acids, nanomaterials, and organic compounds, as well as the research avenues for future development of digitally operating “sense and act” schemes that logically process biochemical signals through networked circuits to implement intelligent control systems. PMID:25587423

Middle and late holocene micromammal pathologies from Cueva Tixi (Tandilia Range, Buenos Aires Province, Argentina).

PubMed

Luna, Leandro; Aranda, Claudia; Quintana, Carlos

2017-09-01

Paleopathology in bones of very small mammals has rarely been studied. Different types of osseous lesions of mammals weighing under 0.2kg, recovered from the Holocene strata of Cueva Tixi archaeological and paleontological site (Tandilia range, province of Buenos Aires, Argentina), are described and discussed in this report. Several types of trauma, entheseal changes, degenerative joint diseases, and probable osteomyelitis were identified. The lesions were chronic, indicating that the animals were able to survive a period of convalescence, although in many cases the decreased capacity for locomotion likely was significant. These pathological findings open research avenues for very small mammals that usually are not considered in archaeological disease studies. Copyright © 2017 Elsevier Inc. All rights reserved.

Single nickel-related defects in molecular-sized nanodiamonds for multicolor bioimaging: an ab initio study.

PubMed

Thiering, Gergő; Londero, Elisa; Gali, Adam

2014-10-21

Fluorescent nanodiamonds constitute an outstanding alternative to semiconductor quantum dots and dye molecules for in vivo biomarker applications, where the fluorescence comes from optically active point defects acting as color centers in the nanodiamonds. For practical purposes, these color centers should be photostable as a function of the laser power or the surface termination of nanodiamonds. Furthermore, they should exhibit a sharp and nearly temperature-independent zero-phonon line. In this study, we show by hybrid density functional theory calculations that nickel doped nanodiamonds exhibit the desired properties, thus opening the avenue to practical applications. In particular, harnessing the strong quantum confinement effect in molecule-sized nanodiamonds is very promising for achieving multicolor imaging by single nickel-related defects.

Single nickel-related defects in molecular-sized nanodiamonds for multicolor bioimaging: an ab initio study

NASA Astrophysics Data System (ADS)

Thiering, Gergő; Londero, Elisa; Gali, Adam

2014-09-01

Fluorescent nanodiamonds constitute an outstanding alternative to semiconductor quantum dots and dye molecules for in vivo biomarker applications, where the fluorescence comes from optically active point defects acting as color centers in the nanodiamonds. For practical purposes, these color centers should be photostable as a function of the laser power or the surface termination of nanodiamonds. Furthermore, they should exhibit a sharp and nearly temperature-independent zero-phonon line. In this study, we show by hybrid density functional theory calculations that nickel doped nanodiamonds exhibit the desired properties, thus opening the avenue to practical applications. In particular, harnessing the strong quantum confinement effect in molecule-sized nanodiamonds is very promising for achieving multicolor imaging by single nickel-related defects.

The Potential of GIS as a Management Tool for Avenue Trees Population in Small Communities; a Case Study of Idi-Shin Community, Ibadan, Nigeria

NASA Astrophysics Data System (ADS)

Olokeogun, O. S.; Akintola, O. O.; Abodunrin, E. K.

2016-06-01

This study demonstrates the potentials of Geographic Information System (GIS) as a management tool for avenue trees (Street trees) populations in small communities (using Idi-Ishin community, Ibadan, Nigeria as a case study). GIS is a decision support system which integrate data or set of data from different sources, bringing them under the same referencing system in a computer system. An Ikonos Imagery (1m Spatial Resolution) of the study area was digitized to produce a digital map using ArcGIS 10.1 version. The avenue trees species ≥ 5cm diameter at breast height (DBH) was selected for enumeration. These trees were then measured and tagged. The Height, Girth and Geographic location (X &Y coordinate) of the trees were measured with Haga altimeter, Girthing tape and Hand held Global Positioning System (GPS) respectively. The species and families of the trees enumerated were also identified. Data were analysed for basal area (BA) and volume (V). A total number of 43 avenue trees were assessed in Idi-Ishin Community. Roystonea regia accounted for the majority of the avenue trees (25.58%), followed by Polyanthia longiflora (23.26%), Gliricida seprium (20.93%), Eucalyptus toreliana (13.95%), Delunix regea (6.98%). However Terminalia catapa, Terminalia radii, Azadrachita indica and Newbodia levis had the same abundance of 2.33%. It was also observed that the benefits derived from these avenue trees includes; Carbon sequestration, Beautification, Wind break and shade. A spatial relational database was created for the assessed avenue trees using ArcCatalog of ArcGIS 10.1 version. Based on the findings from the study (which serves as baseline information for the management of the avenue trees in the study area), it was therefore recommended that subsequent assessment should be carried out at 3-5 year interval in other to ensure proper and continuous monitoring and updating of the data.

Improved Astronomical Instrumentation for the Far Ultra-Violet

NASA Astrophysics Data System (ADS)

Witt, Emily M.; Fleming, Brian; Egan, Arika; Tyler, Rachel; Wiley, James

2018-06-01

Recent technological advances have opened up new instrument capabilities in the ultraviolet. Of particular interest are advanced deposition processes that have made lithium fluoride (LiF) based mirrors more accessible, achieving greater than 80% broadband reflectivity down into the Lyman UV (100 nm). Traditional MgF2 protected aluminum mirrors cut off at 115 nm, missing crucial tracers of warm gas and molecules. The hygroscopic sensitivity of LiF, which adds mission risk and cost, has also been mitigated with a thin capping layer of a more durable substance, making LiF mirrors accessible without onerous environmental procedures. These advances open up a new paradigm in UV astronomy by enabling multi-reflection systems in the Lyman UV. We present recent progress in the testing of eLiF-based optics, and then discuss the potential scientific avenues this opens up in UV astronomy.

Group B streptococcal phospholipid causes pulmonary hypertension

NASA Astrophysics Data System (ADS)

Curtis, Jerri; Kim, Geumsoo; Wehr, Nancy B.; Levine, Rodney L.

2003-04-01

Group B Streptococcus is the most common cause of bacterial infection in the newborn. Infection in many cases causes persistent pulmonary hypertension, which impairs gas exchange in the lung. We purified the bacterial components causing pulmonary hypertension and identified them as cardiolipin and phosphatidylglycerol. Synthetic cardiolipin or phosphatidylglycerol also induced pulmonary hypertension in lambs. The recognition that bacterial phospholipids may cause pulmonary hypertension in newborns with Group B streptococcal infection opens new avenues for therapeutic intervention.

4. DETAIL VIEW (SIDE A) OF HANDMADE STEEL BOX ASSOCIATED ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. DETAIL VIEW (SIDE A) OF HANDMADE STEEL BOX ASSOCIATED WITH THE DEPLETED URANIUM ALLOY DEVELOPMENT AND COMPONENT FABRICATION PROCESS. THE BOX WAS USED TO TRANSFER HEATED BLOCKS OF METAL (SHOWN IN THE OPENED DOOR) FROM THE MOLTEN SALT BATH TO THE ROLLER LINES. (4/28/62) - Rocky Flats Plant, Uranium Rolling & Forming Operations, Southeast section of plant, southeast quadrant of intersection of Central Avenue & Eighth Street, Golden, Jefferson County, CO

Perspective: Materials Informatics and Big Data: Realization of the Fourth Paradigm of Science in Materials Science

DTIC Science & Technology

2016-08-17

thereby opening up new avenues for accelerated materials discovery and design . The need for such data analytics has also been emphasized by the...and design . The construction of inverse models is typically formulated as an optimiza- tion problem wherein a property or performance metric of...discovery and design . extraction, feature selection, etc. Such data preprocessing can either be supervised or unsupervised, based on whether the

Web of Deception: Social Media and Implications for Military Deception

DTIC Science & Technology

2012-12-01

additional deception and OPSEC concerns. 35 Beyond just the open source intelligence ( OSINT ) that can be collected by other entities, there is also a...witting participants, in an effort to mislead or confuse the enemy. Just as the United States would be monitoring social media for OSINT , the...deception. Exploiting adversary use of social media OSINT through DISO is another lower threat avenue to examine as a starting point. As previously

Group B streptococcal phospholipid causes pulmonary hypertension.

PubMed

Curtis, Jerri; Kim, Geumsoo; Wehr, Nancy B; Levine, Rodney L

2003-04-29

Group B Streptococcus is the most common cause of bacterial infection in the newborn. Infection in many cases causes persistent pulmonary hypertension, which impairs gas exchange in the lung. We purified the bacterial components causing pulmonary hypertension and identified them as cardiolipin and phosphatidylglycerol. Synthetic cardiolipin or phosphatidylglycerol also induced pulmonary hypertension in lambs. The recognition that bacterial phospholipids may cause pulmonary hypertension in newborns with Group B streptococcal infection opens new avenues for therapeutic intervention.

Use of Daily Phone Diary to study religiosity and mood: Convergent validity

PubMed Central

Szczesniak, Rhonda D.; Zou, Yuanshu; Dimitriou, Sophia M.; Quittner, Alexandra L.; Grossoehme, Daniel H.

2017-01-01

Studies of religious/spiritual behavior frequently rely on self-reported questionnaire data, which is susceptible to bias. The Daily Phone Diary (DPD) was developed to minimize bias in reporting activities and behavior across a 24-hour period. A cross-sectional study of 126 parents of children with cystic fibrosis was used to establish the validity of the DPD to study religious/spiritual behaviors. Longitudinal models were used to determine the odds of improved mood during religious/spiritual activities. Convergent validity was found. Participants had increased odds of improved mood during religious/spiritual activities compared to non-religious/spiritual activities. Associations with gender and religious affiliations were found. The DPD is a valid tool for studying religious/spiritual activities and opens novel avenues for chaplaincy research and the development of chaplaincy interventions incorporating these findings. PMID:27869567

Theoretical modeling of time-dependent skin temperature and heat losses during whole-body cryotherapy: A pilot study.

PubMed

Polidori, G; Marreiro, A; Pron, H; Lestriez, P; Boyer, F C; Quinart, H; Tourbah, A; Taïar, R

2016-11-01

This article establishes the basics of a theoretical model for the constitutive law that describes the skin temperature and thermolysis heat losses undergone by a subject during a session of whole-body cryotherapy (WBC). This study focuses on the few minutes during which the human body is subjected to a thermal shock. The relationship between skin temperature and thermolysis heat losses during this period is still unknown and have not yet been studied in the context of the whole human body. The analytical approach here is based on the hypothesis that the skin thermal shock during a WBC session can be thermally modelled by the sum of both radiative and free convective heat transfer functions. The validation of this scientific approach and the derivation of temporal evolution thermal laws, both on skin temperature and dissipated thermal power during the thermal shock open many avenues of large scale studies with the aim of proposing individualized cryotherapy protocols as well as protocols intended for target populations. Furthermore, this study shows quantitatively the substantial imbalance between human metabolism and thermolysis during WBC, the explanation of which remains an open question. Copyright © 2016 Elsevier Ltd. All rights reserved.

Four centuries later: how to close the Galileo case?

PubMed

Segre, Michael

The "Galileo case" is still open: John Paul II's 1979 initiative to "recognize wrongs from whatever side they come" was carried out in an unsatisfactory manner. The task would have been easy had the Pontifical Study Commission created for that purpose concentrated on the 1616 decree alone and declared it not in line with the hermeneutical guidelines of the Council of Trent, in agreement with Galileo and not with Saint Robert Bellarmine. A possible avenue to closing the "Galileo case" on the part of the Church of Rome could, thus, be to change its current defensive attitude and declare itself no longer what it was in 1616, since another such "case" is, hopefully, no longer conceivable.

[Induced pluripotent stem cells: a new paradigm to study human tissues].

PubMed

Sansac, Caroline; Assou, Said; Bouckenheimer, Julien; Lemaître, Jean-Marc; De Vos, John

2016-01-01

Induced pluripotent stem cells (iPSCs) are obtained by reprogramming differentiated cells through forced expression of four embryonic transcription factors. The discovery of this technology, able to transform a differentiated cell into a pluripotent cell, has profoundly shifted the paradigm of the concept of cell identity, since it is now possible to obtain in vitro any cell type from an initial sample of skin or blood cells from a healthy volunteer or patient. Applications of iPSCs are exceedingly large, and comprise the in vitro modeling of normal or pathological tissues, including for massive drug screening. They also open new therapeutic avenues in the field of regenerative medicine. © Société de Biologie, 2016.

Surface enhanced Raman scattering on Tardigrada--towards monitoring and imaging molecular structures in live cryptobiotic organisms.

PubMed

Kneipp, Harald; Møbjerg, Nadja; Jørgensen, Aslak; Bohr, Henrik G; Hélix-Nielsen, Claus; Kneipp, Janina; Kneipp, Katrin

2013-10-01

Tardigrades are microscopic metazoans which are able to survive extreme physical and chemical conditions by entering a stress tolerant state called cryptobiosis. At present, the molecular mechanisms behind cryptobiosis are still poorly understood. We show that surface enhanced Raman scattering supported by plasmonic gold nanoparticles can measure molecular constituents and their local distribution in live tardigrades. Surface enhanced Raman signatures allow to differentiate between two species and indicate molecular structural differences between tardigrades in water and in a dry state. This opens new avenues for exploring cryptobiosis by studying molecular changes in live cryptobiotic organisms. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

"It Ain't Over 'til It's Over" (a) -The Search for Treatments and Cures for Alzheimer's Disease.

PubMed

Hargreaves, Richard J

2012-11-08

In the neuroscience landscape, there is no condition with higher unmet medical and societal need than Alzheimer's disease (AD). There are significant opportunities to improve upon symptomatic treatments in AD, and as yet, there are no treatments to modify (slow, stop, or prevent) underlying disease progression. Our goals are to discover new symptomatic AD therapies with improved efficacy and longevity; to complete definitive studies that refute or prove the amyloid hypothesis, potentially opening multiple avenues to new therapeutic modalities; and to initiate tests of novel mechanisms that can prevent tau pathology and neurodegeneration. It's a critical time in the testing of novel AD therapeutics-let's hope we succeed.

Novel core-shell (TiO2@Silica) nanoparticles for scattering medium in a random laser: higher efficiency, lower laser threshold and lower photodegradation.

PubMed

Jimenez-Villar, Ernesto; Mestre, Valdeci; de Oliveira, Paulo C; de Sá, Gilberto F

2013-12-21

There has been growing interest in scattering media in recent years, due to their potential applications as solar collectors, photocatalyzers, random lasers and other novel optical devices. Here, we have introduced a novel core-shell scattering medium for a random laser composed of TiO2@Silica nanoparticles. Higher efficiency, lower laser threshold and long photobleaching lifetime in random lasers were demonstrated. This has introduced a new method or parameter (fraction of absorbed pumping), which opens a new avenue to characterize and study the scattering media. Optical chemical and colloidal stabilities were combined by coating a suitable silica shell onto TiO2 nanoparticles.

Observing the dynamics of supermassive black hole binaries with pulsar timing arrays.

PubMed

Mingarelli, C M F; Grover, K; Sidery, T; Smith, R J E; Vecchio, A

2012-08-24

Pulsar timing arrays are a prime tool to study unexplored astrophysical regimes with gravitational waves. Here, we show that the detection of gravitational radiation from individually resolvable supermassive black hole binary systems can yield direct information about the masses and spins of the black holes, provided that the gravitational-wave-induced timing fluctuations both at the pulsar and at Earth are detected. This in turn provides a map of the nonlinear dynamics of the gravitational field and a new avenue to tackle open problems in astrophysics connected to the formation and evolution of supermassive black holes. We discuss the potential, the challenges, and the limitations of these observations.

Aging and reprogramming: a two-way street

PubMed Central

Mahmoudi, Salah; Brunet, Anne

2012-01-01

Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a striking increase in a wide range of diseases. The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) opens new avenues for the aging field and has important applications for therapeutic treatments of age-related diseases. Here we review emerging studies on how aging and age-related pathways influence iPSC generation and property. We discuss the exciting possibility that reverting to a pluripotent stem cell stage erases several deficits associated with aging and will provide new strategies for rejuvenation. Finally, we argue that reprogramming provides a unique opportunity to model aging and perhaps exceptional longevity. PMID:23146768

Two-Dimensional-Material Membranes: A New Family of High-Performance Separation Membranes.

PubMed

Liu, Gongping; Jin, Wanqin; Xu, Nanping

2016-10-17

Two-dimensional (2D) materials of atomic thickness have emerged as nano-building blocks to develop high-performance separation membranes that feature unique nanopores and/or nanochannels. These 2D-material membranes exhibit extraordinary permeation properties, opening a new avenue to ultra-fast and highly selective membranes for water and gas separation. Summarized in this Minireview are the latest ground-breaking studies in 2D-material membranes as nanosheet and laminar membranes, with a focus on starting materials, nanostructures, and transport properties. Challenges and future directions of 2D-material membranes for wide implementation are discussed briefly. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Functional magnetic resonance microscopy at single-cell resolution in Aplysia californica

PubMed Central

Radecki, Guillaume; Nargeot, Romuald; Jelescu, Ileana Ozana; Le Bihan, Denis; Ciobanu, Luisa

2014-01-01

In this work, we show the feasibility of performing functional MRI studies with single-cell resolution. At ultrahigh magnetic field, manganese-enhanced magnetic resonance microscopy allows the identification of most motor neurons in the buccal network of Aplysia at low, nontoxic Mn2+ concentrations. We establish that Mn2+ accumulates intracellularly on injection into the living Aplysia and that its concentration increases when the animals are presented with a sensory stimulus. We also show that we can distinguish between neuronal activities elicited by different types of stimuli. This method opens up a new avenue into probing the functional organization and plasticity of neuronal networks involved in goal-directed behaviors with single-cell resolution. PMID:24872449

Exploration and Description of Faith-Based Health Resources: Findings Inform Advancing Holistic Health Care.

PubMed

Dyess, Susan MacLeod

2015-01-01

It is important to use all holistic resource opportunities in communities, such as integrative healing centers, and mind-body-spirit approaches to health. These holistic approaches may be realized through nontraditional avenues, such as faith-based resources. This article reports on an exploratory study that describes faith-based resources supporting holistic health in a southeastern region of the United States. A working definition for "faith-based health resources" was "ecumenical and interfaith community-based, open-access health resources that include in mission for service a reference to faith." Excluded from the definition were institutional services from hospitals, focused social services from area agencies, and federally funded services.

Intelligent screening of electrofusion-polyethylene joints based on a thermal NDT method

NASA Astrophysics Data System (ADS)

Doaei, Marjan; Tavallali, M. Sadegh

2018-05-01

The combinations of infrared thermal images and artificial intelligence methods have opened new avenues for pushing the boundaries of available testing methods. Hence, in the current study, a novel thermal non-destructive testing method for polyethylene electrofusion joints was combined with k-means clustering algorithms as an intelligent screening tool. The experiments focused on ovality of pipes in the coupler, as well as misalignment of pipes-couplers in 25 mm diameter joints. The temperature responses of each joint to an internal heat pulse were recorded by an IR thermal camera, and further processed to identify the faulty joints. The results represented clustering accuracy of 92%, as well as more than 90% abnormality detection capabilities.

Determination of noise and vibration impacts of construction and operation of the Second Avenue Subway

NASA Astrophysics Data System (ADS)

Pristera, Jessica L.

2004-05-01

An acoustical study was conducted to determine the potential for airborne noise and ground-borne noise and vibration impacts generated by construction and operation of the Second Avenue Subway. The study was performed in support of an environmental impact statement (EIS) that defined the areas along the proposed Second Avenue Subway corridor where any significiant impacts would occur as a result of construction activity and operation of the Second Avenue Subway. Using FTA guideline procedures, project-generated noise levels from subway construction and operations were determined. Construction noise levels exceeded operational noise levels. With limited alternative construction methods, practical mitigation methods were determined to reduce impacts.

Bright x-rays reveal shifting deformation states and effects of the microstructure on the plastic deformation of crystalline materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beaudoin, A. J.; Shade, P. A.; Schuren, J. C.

The plastic deformation of crystalline materials is usually modeled as smoothly progressing in space and time, yet modern studies show intermittency in the deformation dynamics of single-crystals arising from avalanche behavior of dislocation ensembles under uniform applied loads. However, once the prism of the microstructure in polycrystalline materials disperses and redistributes the load on a grain-by-grain basis, additional length and time scales are involved. Thus, the question is open as to how deformation intermittency manifests for the nonuniform grain-scale internal driving forces interacting with the finer-scale dislocation ensemble behavior. In this work we track the evolution of elastic strain withinmore » individual grains of a creep-loaded titanium alloy, revealing widely varying internal strains that fluctuate over time. Here, the findings provide direct evidence of how flow intermittency proceeds for an aggregate of ~700 grains while showing the influences of multiscale ensemble interactions and opening new avenues for advancing plasticity modeling.« less

Bright x-rays reveal shifting deformation states and effects of the microstructure on the plastic deformation of crystalline materials

DOE PAGES

Beaudoin, A. J.; Shade, P. A.; Schuren, J. C.; ...

2017-11-30

The plastic deformation of crystalline materials is usually modeled as smoothly progressing in space and time, yet modern studies show intermittency in the deformation dynamics of single-crystals arising from avalanche behavior of dislocation ensembles under uniform applied loads. However, once the prism of the microstructure in polycrystalline materials disperses and redistributes the load on a grain-by-grain basis, additional length and time scales are involved. Thus, the question is open as to how deformation intermittency manifests for the nonuniform grain-scale internal driving forces interacting with the finer-scale dislocation ensemble behavior. In this work we track the evolution of elastic strain withinmore » individual grains of a creep-loaded titanium alloy, revealing widely varying internal strains that fluctuate over time. Here, the findings provide direct evidence of how flow intermittency proceeds for an aggregate of ~700 grains while showing the influences of multiscale ensemble interactions and opening new avenues for advancing plasticity modeling.« less

General view, marine aviation hangars, looking northwest. Oral history has ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view, marine aviation hangars, looking northwest. Oral history has suggested that the north unit of the two surviving structures (in the background with the gable roof) was used as a repair shed by what is now the Philadelphia International Airport when it opened in 1925, and the south (doubled) unit was constructed as part of the 1926 Sesqui-Centennial Exposition. - Lazaretto Quarantine Station, Marine Aviation Hangars, Wanamaker Avenue and East Second Street, Essington, Delaware County, PA

Formation and rearrangement of homoserine depsipeptides and depsiproteins in the α-ketoacid-hydroxylamine ligation with 5-oxaproline.

PubMed

Wucherpfennig, Thomas G; Rohrbacher, Florian; Pattabiraman, Vijaya R; Bode, Jeffrey W

2014-11-03

The primary products of the chemical ligation of α-ketoacids and 5-oxaproline peptides are esters, rather than the previously reported amides. The depsipeptide product rapidly rearranges to the amide in basic buffers. The formation of esters sheds light on possible mechanisms for the type II KAHA ligations and opens an avenue for the chemical synthesis of depsiproteins. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

1. Streetscape with south sides of Medical Detachment Barracks on ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Streetscape with south sides of Medical Detachment Barracks on Ramp No. 5. Part of Building No. 9962-A with door is on far right. Also shown are the south A-sides of Buildings Nos. 9963, 9964, 9965, 9966, 9967 and 9968. The new Madigan Army Medical Center, which opened in 1992, is in far distance on right. - Madigan Hospital, Medical Detachment Barracks, Bounded by Wilson & McKinley Avenues & Garfield & Lincoln Streets, Tacoma, Pierce County, WA

The MAL: A Malware Analysis Lexicon

DTIC Science & Technology

2013-02-01

we feel that further exploration of the open source literature is a promising avenue for enlarging the corpus. 2.3 Publishing the MAL Early in the...MAL. We feel that the advantages of this format are well worth the small incremental cost. The distribution of the MAL in this format is under...dictionary. We feel that moving to a richer format such as WordNet or WordVis would greatly improve the usability of the lexicon. 3.5 Improved Hosting The

Self-assembled quantum dot structures in a hexagonal nanowire for quantum photonics.

PubMed

Yu, Ying; Dou, Xiu-Ming; Wei, Bin; Zha, Guo-Wei; Shang, Xiang-Jun; Wang, Li; Su, Dan; Xu, Jian-Xing; Wang, Hai-Yan; Ni, Hai-Qiao; Sun, Bao-Quan; Ji, Yuan; Han, Xiao-Dong; Niu, Zhi-Chuan

2014-05-01

Two types of quantum nanostructures based on self-assembled GaAs quantumdots embedded into GaAs/AlGaAs hexagonal nanowire systems are reported, opening a new avenue to the fabrication of highly efficient single-photon sources, as well as the design of novel quantum optics experiments and robust quantum optoelectronic devices operating at higher temperature, which are required for practical quantum photonics applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Discovering charge density functionals and structure-property relationships with PROPhet: A general framework for coupling machine learning and first-principles methods

DOE PAGES

Kolb, Brian; Lentz, Levi C.; Kolpak, Alexie M.

2017-04-26

Modern ab initio methods have rapidly increased our understanding of solid state materials properties, chemical reactions, and the quantum interactions between atoms. However, poor scaling often renders direct ab initio calculations intractable for large or complex systems. There are two obvious avenues through which to remedy this problem: (i) develop new, less expensive methods to calculate system properties, or (ii) make existing methods faster. This paper describes an open source framework designed to pursue both of these avenues. PROPhet (short for PROPerty Prophet) utilizes machine learning techniques to find complex, non-linear mappings between sets of material or system properties. Themore » result is a single code capable of learning analytical potentials, non-linear density functionals, and other structure-property or property-property relationships. These capabilities enable highly accurate mesoscopic simulations, facilitate computation of expensive properties, and enable the development of predictive models for systematic materials design and optimization. Here, this work explores the coupling of machine learning to ab initio methods through means both familiar (e.g., the creation of various potentials and energy functionals) and less familiar (e.g., the creation of density functionals for arbitrary properties), serving both to demonstrate PROPhet’s ability to create exciting post-processing analysis tools and to open the door to improving ab initio methods themselves with these powerful machine learning techniques.« less

Discovering charge density functionals and structure-property relationships with PROPhet: A general framework for coupling machine learning and first-principles methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kolb, Brian; Lentz, Levi C.; Kolpak, Alexie M.

Modern ab initio methods have rapidly increased our understanding of solid state materials properties, chemical reactions, and the quantum interactions between atoms. However, poor scaling often renders direct ab initio calculations intractable for large or complex systems. There are two obvious avenues through which to remedy this problem: (i) develop new, less expensive methods to calculate system properties, or (ii) make existing methods faster. This paper describes an open source framework designed to pursue both of these avenues. PROPhet (short for PROPerty Prophet) utilizes machine learning techniques to find complex, non-linear mappings between sets of material or system properties. Themore » result is a single code capable of learning analytical potentials, non-linear density functionals, and other structure-property or property-property relationships. These capabilities enable highly accurate mesoscopic simulations, facilitate computation of expensive properties, and enable the development of predictive models for systematic materials design and optimization. Here, this work explores the coupling of machine learning to ab initio methods through means both familiar (e.g., the creation of various potentials and energy functionals) and less familiar (e.g., the creation of density functionals for arbitrary properties), serving both to demonstrate PROPhet’s ability to create exciting post-processing analysis tools and to open the door to improving ab initio methods themselves with these powerful machine learning techniques.« less

Serial Femtosecond Crystallography Opens New Avenues for Structural Biology

PubMed Central

Coe, Jesse; Fromme, Petra

2016-01-01

Free electron lasers (FELs) provide X-ray pulses in the femtosecond time domain with up to 1012 higher photon flux than synchrotrons and open new avenues for the determination of difficult to crystallize proteins, like large complexes and human membrane proteins. While the X-ray pulses are so strong that they destroy any solid material, the crystals diffract before they are destroyed. The most successful application of FELs for biology has been the method of serial femtosecond crystallography (SFX) where nano or microcrystals are delivered to the FEL beam in a stream of their mother liquid at room temperature, which ensures the replenishment of the sample before the next X-ray pulse arrives. New injector technology allows also for the delivery of crystal in lipidic cubic phases or agarose, which reduces the sample amounts for an SFX data set by two orders of magnitude. Time-resolved SFX also allows for analysis of the dynamics of biomolecules, the proof of principle being recently shown for light-induced reactions in photosystem II and photoactive yellow protein. An SFX data sets consist of thousands of single crystal snapshots in random orientations, which can be analyzed now “on the fly” by data analysis programs specifically developed for SFX, but de-novo phasing is still a challenge, that might be overcome by two-color experiments or phasing by shape transforms. PMID:26786767

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

PubMed Central

2016-01-01

The development of new antimalarial compounds remains a pivotal part of the strategy for malaria elimination. Recent large-scale phenotypic screens have provided a wealth of potential starting points for hit-to-lead campaigns. One such public set is explored, employing an open source research mechanism in which all data and ideas were shared in real time, anyone was able to participate, and patents were not sought. One chemical subseries was found to exhibit oral activity but contained a labile ester that could not be replaced without loss of activity, and the original hit exhibited remarkable sensitivity to minor structural change. A second subseries displayed high potency, including activity within gametocyte and liver stage assays, but at the cost of low solubility. As an open source research project, unexplored avenues are clearly identified and may be explored further by the community; new findings may be cumulatively added to the present work. PMID:27800551

Stationary Light Pulses in Cold Atomic Media and without Bragg Gratings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Y.-W.; Liao, W.-T.; Peters, Thorsten

We study the creation of stationary light pulses (SLPs), i.e., light pulses without motion, based on the effect of electromagnetically induced transparency with two counterpropagating coupling fields in cold atoms. We show that the Raman excitations created by counterpropagating probe and coupling fields prohibit the formation of SLPs in media of cold and stationary atoms such as laser-cooled atom clouds, Bose condensates or color-center crystals. A method is experimentally demonstrated to suppress these Raman excitations and SLPs are realized in laser-cooled atoms. Furthermore, we report the first experimental observation of a bichromatic SLP at wavelengths for which no Bragg gratingmore » can be established. Our work advances the understanding of SLPs and opens a new avenue to SLP studies for few-photon nonlinear interactions.« less

Plant Systems Biology at the Single-Cell Level.

PubMed

Libault, Marc; Pingault, Lise; Zogli, Prince; Schiefelbein, John

2017-11-01

Our understanding of plant biology is increasingly being built upon studies using 'omics and system biology approaches performed at the level of the entire plant, organ, or tissue. Although these approaches open new avenues to better understand plant biology, they suffer from the cellular complexity of the analyzed sample. Recent methodological advances now allow plant scientists to overcome this limitation and enable biological analyses of single-cells or single-cell-types. Coupled with the development of bioinformatics and functional genomics resources, these studies provide opportunities for high-resolution systems analyses of plant phenomena. In this review, we describe the recent advances, current challenges, and future directions in exploring the biology of single-cells and single-cell-types to enhance our understanding of plant biology as a system. Copyright © 2017 Elsevier Ltd. All rights reserved.

Current at Metal-Organic Interfaces

NASA Astrophysics Data System (ADS)

Kern, Klaus

2012-02-01

Charge transport through atomic and molecular constrictions greatly affects the operation and performance of organic electronic devices. Much of our understanding of the charge injection and extraction processes in these systems relays on our knowledge of the electronic structure at the metal-organic interface. Despite significant experimental and theoretical advances in studying charge transport in nanoscale junctions, a microscopic understanding at the single atom/molecule level is missing. In the present talk I will present our recent results to probe directly the nanocontact between single molecules and a metal electrode using scanning probe microscopy and spectroscopy. The experiments provide unprecedented microscopic details of single molecule and atom junctions and open new avenues to study quantum critical and many body phenomena at the atomic scale. Implications for energy conversion devices and carbon based nanoelectronics will also be discussed.

PSYCHOANALYSIS AND THE ARTS: THE SLIPPERY GROUND OF APPLIED ANALYSIS.

PubMed

Abella, Adela

2016-01-01

The ways in which today's psychoanalysts approach art closely follow the avenues opened by Freud a hundred years ago. Drawing mainly on Freud's studies on Jensen's Gradiva (1907) and on Leonardo da Vinci (1910a), the author examines the main paradigms he used in discussing artistic activity, including his doubts and hesitations. Present-day approaches to art are then examined via a discussion of the advantages and pitfalls of psychobiography, of the case study, and of textual approaches. The author makes a case for the type of interdisciplinary dialogue in which the goal is to establish a cross-fertilization between psychoanalysis and other fields of knowledge while striving to avoid hypersaturation of a work of art in order to foster expansion of the mind. © 2016 The Psychoanalytic Quarterly, Inc.

Realization of two-dimensional spin-orbit coupling for Bose-Einstein condensates.

PubMed

Wu, Zhan; Zhang, Long; Sun, Wei; Xu, Xiao-Tian; Wang, Bao-Zong; Ji, Si-Cong; Deng, Youjin; Chen, Shuai; Liu, Xiong-Jun; Pan, Jian-Wei

2016-10-07

Cold atoms with laser-induced spin-orbit (SO) interactions provide a platform to explore quantum physics beyond natural conditions of solids. Here we propose and experimentally realize two-dimensional (2D) SO coupling and topological bands for a rubidium-87 degenerate gas through an optical Raman lattice, without phase-locking or fine-tuning of optical potentials. A controllable crossover between 2D and 1D SO couplings is studied, and the SO effects and nontrivial band topology are observed by measuring the atomic cloud distribution and spin texture in momentum space. Our realization of 2D SO coupling with advantages of small heating and topological stability opens a broad avenue in cold atoms to study exotic quantum phases, including topological superfluids. Copyright © 2016, American Association for the Advancement of Science.

Molecular Wiring in Smart Dressings: Opening a New Route to Monitoring Wound pH

PubMed Central

McLister, Anna; Davis, James

2015-01-01

It has been proposed that fluctuations in wound pH can give valuable insights into the healing processes in chronic wounds, but acquiring such data can be a technological challenge especially where there is little sample available. Developments in voltammetric pH sensing have opened up new avenues for the design of probes that can function in ultra-small volumes and can be inherently disposable but, as yet few can meet the demands of wound monitoring. A preliminary investigation of the pH response of a new redox wire prepared from a peptide homopolymer of tryptophan is presented and its potential applicability as a sensing material for use in smart dressings is critically discussed. PMID:27417774

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ulvestad, Andrew; Sasikumar, Kiran; Kim, Jong Woo

Multielectron transfer processes are crucially important in energy and biological science but require favorable catalysts to achieve fast kinetics. Nanostructuring catalysts can dramatically improve their properties, which can be difficult to understand due to strain- and size-dependent thermodynamics, the influence of defects, and substrate-dependent activities. Here, we report three-dimensional (3D) imaging of single gold nanoparticles during catalysis of ascorbic acid decomposition using Bragg coherent diffractive imaging (BCDI). Local strains were measured in single nanoparticles and modeled using reactive molecular dynamics (RMD) simulations and finite element analysis (FEA) simulations. RMD reveals the pathway for local strain generation in the gold lattice:more » chemisorption of hydroxyl ions. FEA reveals that the RMD results are transferable to the nanocrystal sizes studied in the experiment. Our study probes the strain-activity connection and opens a powerful avenue for theoretical and experimental studies of nanocrystal catalysis.« less

Overview taken from the corner of Avenue E (Russell Avenue) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Overview taken from the corner of Avenue E (Russell Avenue) and Central Avenue. Facility 167 in background. View facing northwest - U.S. Naval Base, Pearl Harbor, Administration Annex, Near Russell Avenue (previously Avenue E), between of Facility Nos. 1C & 1E , Pearl City, Honolulu County, HI

Molecular Dynamics Simulation Reveals Correlated Inter-Lobe Motion in Protein Lysine Methyltransferase SMYD2.

PubMed

Spellmon, Nicholas; Sun, Xiaonan; Sirinupong, Nualpun; Edwards, Brian; Li, Chunying; Yang, Zhe

2015-01-01

SMYD proteins are an exciting field of study as they are linked to many types of cancer-related pathways. Cardiac and skeletal muscle development and function also depend on SMYD proteins opening a possible avenue for cardiac-related treatment. Previous crystal structure studies have revealed that this special class of protein lysine methyltransferases have a bilobal structure, and an open-closed motion may regulate substrate specificity. Here we use the molecular dynamics simulation to investigate the still-poorly-understood SMYD2 dynamics. Cross-correlation analysis reveals that SMYD2 exhibits a negative correlated inter-lobe motion. Principle component analysis suggests that this correlated dynamic is contributed to by a twisting motion of the C-lobe with respect to the N-lobe and a clamshell-like motion between the lobes. Dynamical network analysis defines possible allosteric paths for the correlated dynamics. There are nine communities in the dynamical network with six in the N-lobe and three in the C-lobe, and the communication between the lobes is mediated by a lobe-bridging β hairpin. This study provides insight into the dynamical nature of SMYD2 and could facilitate better understanding of SMYD2 substrate specificity.

Aspiration dynamics in structured population acts as if in a well-mixed one.

PubMed

Du, Jinming; Wu, Bin; Wang, Long

2015-01-26

Understanding the evolution of human interactive behaviors is important. Recent experimental results suggest that human cooperation in spatial structured population is not enhanced as predicted in previous works, when payoff-dependent imitation updating rules are used. This constraint opens up an avenue to shed light on how humans update their strategies in real life. Studies via simulations show that, instead of comparison rules, self-evaluation driven updating rules may explain why spatial structure does not alter the evolutionary outcome. Though inspiring, there is a lack of theoretical result to show the existence of such evolutionary updating rule. Here we study the aspiration dynamics, and show that it does not alter the evolutionary outcome in various population structures. Under weak selection, by analytical approximation, we find that the favored strategy in regular graphs is invariant. Further, we show that this is because the criterion under which a strategy is favored is the same as that of a well-mixed population. By simulation, we show that this holds for random networks. Although how humans update their strategies is an open question to be studied, our results provide a theoretical foundation of the updating rules that may capture the real human updating rules.

Optical instruments synergy in determination of optical depth of thin clouds

NASA Astrophysics Data System (ADS)

Viviana Vlăduţescu, Daniela; Schwartz, Stephen E.; Huang, Dong

2018-04-01

Optically thin clouds have a strong radiative effect and need to be represented accurately in climate models. Cloud optical depth of thin clouds was retrieved using high resolution digital photography, lidar, and a radiative transfer model. The Doppler Lidar was operated at 1.5 μm, minimizing return from Rayleigh scattering, emphasizing return from aerosols and clouds. This approach examined cloud structure on scales 3 to 5 orders of magnitude finer than satellite products, opening new avenues for examination of cloud structure and evolution.

Remanagement of Singlet and Triplet Excitons in Single-Emissive-Layer Hybrid White Organic Light-Emitting Devices Using Thermally Activated Delayed Fluorescent Blue Exciplex.

PubMed

Liu, Xiao-Ke; Chen, Zhan; Qing, Jian; Zhang, Wen-Jun; Wu, Bo; Tam, Hoi Lam; Zhu, Furong; Zhang, Xiao-Hong; Lee, Chun-Sing

2015-11-25

A high-performance hybrid white organic light-emitting device (WOLED) is demonstrated based on an efficient novel thermally activated delayed fluorescence (TADF) blue exciplex system. This device shows a low turn-on voltage of 2.5 V and maximum forward-viewing external quantum efficiency of 25.5%, which opens a new avenue for achieving high-performance hybrid WOLEDs with simple structures. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Investigation of air transportation technology at Princeton University, 1986

NASA Technical Reports Server (NTRS)

Stengel, Robert F.

1988-01-01

The Air Transportation Technology Program at Princeton proceeded along four avenues: Guidance and control strategies for penetration of microbursts and wind shear; Application of artificial intelligence in flight control systems; Computer aided control system design; and Effects of control saturation on closed loop stability and response of open loop unstable aircraft. Areas of investigation relate to guidance and control of commercial transports as well as general aviation aircraft. Interaction between the flight crew and automatic systems is a subject of prime concern.

New Approach to Road Construction in Oil-Producing Regions of Western Siberia

NASA Astrophysics Data System (ADS)

Piirainen, V. Y.; Estrin, Y.

2017-10-01

This article presents, as a polemic exercise, a new approach to road construction in marshland areas of oil and gas producing regions of Western Siberia. The approach is based on the use of novel modular elements that can be assembled into an integral structure by means of topological interlocking. The use of modern superlight concrete in conjunction with the new design systems based on the modular principle opens up new avenues to solving problems of road construction in regions with unstable, boggy soils.

Laboratory Cultivation and Maintenance of Borrelia miyamotoi.

PubMed

Stone, Brandee L; Brissette, Catherine A

2016-08-12

Borrelia miyamotoi is a relapsing fever tick-borne pathogen found in Ixodes spp. (hard) ticks. In vitro culturing has proven difficult despite initial reports of cultures maintained in Barbour-Stoenner-Kelly-II (BSK-II) medium. The ability to culture in vitro opens many avenues for investigating the genetics and physiology of bacterial species. This unit describes methods for the maintenance and cultivation of B. miyamotoi in liquid medium. © 2016 by John Wiley & Sons, Inc. Copyright © 2016 John Wiley & Sons, Inc.

Optical Instruments Synergy in Determination of Optical Depth of Thin Clouds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vladutescu, Daniela V.; Schwartz, Stephen E.

Optically thin clouds have a strong radiative effect and need to be represented accurately in climate models. Cloud optical depth of thin clouds was retrieved using high resolution digital photography, lidar, and a radiative transfer model. The Doppler Lidar was operated at 1.5 μm, minimizing return from Rayleigh scattering, emphasizing return from aerosols and clouds. This approach examined cloud structure on scales 3 to 5 orders of magnitude finer than satellite products, opening new avenues for examination of cloud structure and evolution.

Method for image reconstruction of moving radionuclide source distribution

DOEpatents

Stolin, Alexander V.; McKisson, John E.; Lee, Seung Joon; Smith, Mark Frederick

2012-12-18

A method for image reconstruction of moving radionuclide distributions. Its particular embodiment is for single photon emission computed tomography (SPECT) imaging of awake animals, though its techniques are general enough to be applied to other moving radionuclide distributions as well. The invention eliminates motion and blurring artifacts for image reconstructions of moving source distributions. This opens new avenues in the area of small animal brain imaging with radiotracers, which can now be performed without the perturbing influences of anesthesia or physical restraint on the biological system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurtado, Antonio, E-mail: antonio.hurtado@strath.ac.uk; Javaloyes, Julien

Multiple controllable spiking patterns are achieved in a 1310 nm Vertical-Cavity Surface Emitting Laser (VCSEL) in response to induced perturbations and for two different cases of polarized optical injection, namely, parallel and orthogonal. Furthermore, reproducible spiking responses are demonstrated experimentally at sub-nanosecond speed resolution and with a controlled number of spikes fired. This work opens therefore exciting research avenues for the use of VCSELs in ultrafast neuromorphic photonic systems for non-traditional computing applications, such as all-optical binary-to-spiking format conversion and spiking information encoding.

Stability of an aqueous quadrupole micro-trap

DOE PAGES

Park, Jae Hyun; Krstić, Predrag S.

2012-03-30

Recently demonstrated functionality of an aqueous quadrupole micro- or nano-trap opens a new avenue for applications of the Paul traps, like is confinement of a charged biomolecule which requires water environment for its chemical stability. Besides strong viscosity forces, motion of a charged particle in the aqueous trap is subject to dielectrophoretic and electrophoretic forces. In this study, we describe the general conditions for stability of a charged particle in an aqueous quadrupole trap. We find that for the typical micro-trap parameters, effects of both dielectrophoresis and electrophoresis significantly influence the trap stability. In particular, the aqueous quadrupole trap couldmore » play of a role of a synthetic virtual nanopore for the 3rd generation of DNA sequencing technology.« less

Mapping children’s politics: the promise of articulation and the limits of nonrepresentational theory

PubMed Central

Mitchell, Katharyne; Elwood, Sarah

2015-01-01

Reflecting wider debates in the discipline, recent scholarship in children’s geographies has focused attention on the meanings of the political. While supportive of work that opens up new avenues for conceptualizing politics beyond the liberal rational subject, we provide a critique of research methods which delink politics from historical context and relations of power. Focusing on the use of nonrepresentational theory as a research methodology, the paper points to the limits of this approach for children’s political formation as well as for sustained scholarly collaboration. We argue instead for a politics of articulation, in the double sense of communication and connection. An empirical case study is used as an illustrative example. PMID:25635154

Folding and unfolding single RNA molecules under tension

PubMed Central

Woodside, Michael T; García-García, Cuauhtémoc; Block, Steven M

2010-01-01

Single-molecule force spectroscopy constitutes a powerful method for probing RNA folding: it allows the kinetic, energetic, and structural properties of intermediate and transition states to be determined quantitatively, yielding new insights into folding pathways and energy landscapes. Recent advances in experimental and theoretical methods, including fluctuation theorems, kinetic theories, novel force clamps, and ultrastable instruments, have opened new avenues for study. These tools have been used to probe folding in simple model systems, for example, RNA and DNA hairpins. Knowledge gained from such systems is helping to build our understanding of more complex RNA structures composed of multiple elements, as well as how nucleic acids interact with proteins involved in key cellular activities, such as transcription and translation. PMID:18786653

Preparation of Magnetic Carbon Nanotubes (Mag-CNTs) for Biomedical and Biotechnological Applications

PubMed Central

Masotti, Andrea; Caporali, Andrea

2013-01-01

Carbon nanotubes (CNTs) have been widely studied for their potential applications in many fields from nanotechnology to biomedicine. The preparation of magnetic CNTs (Mag-CNTs) opens new avenues in nanobiotechnology and biomedical applications as a consequence of their multiple properties embedded within the same moiety. Several preparation techniques have been developed during the last few years to obtain magnetic CNTs: grafting or filling nanotubes with magnetic ferrofluids or attachment of magnetic nanoparticles to CNTs or their polymeric coating. These strategies allow the generation of novel versatile systems that can be employed in many biotechnological or biomedical fields. Here, we review and discuss the most recent papers dealing with the preparation of magnetic CNTs and their application in biomedical and biotechnological fields. PMID:24351838

Improving Informed Consent with Minority Participants: Results from Researcher and Community Surveys

PubMed Central

Quinn, Sandra Crouse; Garza, Mary A.; Butler, James; Fryer, Craig S.; Casper, Erica T.; Thomas, Stephen B.; Barnard, David; Kim, Kevin H.

2013-01-01

Strengthening the informed consent process is one avenue for improving recruitment of minorities into research. This study examines that process from two different perspectives, that of researchers and that of African American and Latino community members. Through the use of two separate surveys, we compared strategies used by researchers with the preferences and attitudes of community members during the informed consent process. Our data suggest that researchers can improve the informed consent process by incorporating methods preferred by the community members along with methods shown in the literature for increasing comprehension. With this approach, the informed consent process may increase both participants’ comprehension of the material and overall satisfaction, fostering greater trust in research and openness to future research opportunities. PMID:23324203

Note: Mechanical in situ exfoliation of van der Waals materials

NASA Astrophysics Data System (ADS)

Pásztor, Á.; Scarfato, A.; Renner, Ch.

2017-07-01

Exfoliation, namely, the peeling of layered materials down to a single unit-cell thin foil, opens promising avenues to fabricate novel electronic materials. New properties and original functionalities emerge in the single and few layer configurations of a number of layered compounds, in particular in transition metal dichalcogenides. However, many of these thin exfoliated materials are very sensitive to ambient conditions impeding the exploration of this new and fascinating parameter space. Here we describe a method of mechanical exfoliation in ultra-high vacuum (UHV). This technique is easily adaptable to any UHV system and allows preparing and studying air sensitive nanoflakes in situ. We present the basic design and proof-of-concept scanning tunneling microscopy imaging of VSe2 nanoflakes.

Preparation of magnetic carbon nanotubes (Mag-CNTs) for biomedical and biotechnological applications.

PubMed

Masotti, Andrea; Caporali, Andrea

2013-12-18

Carbon nanotubes (CNTs) have been widely studied for their potential applications in many fields from nanotechnology to biomedicine. The preparation of magnetic CNTs (Mag-CNTs) opens new avenues in nanobiotechnology and biomedical applications as a consequence of their multiple properties embedded within the same moiety. Several preparation techniques have been developed during the last few years to obtain magnetic CNTs: grafting or filling nanotubes with magnetic ferrofluids or attachment of magnetic nanoparticles to CNTs or their polymeric coating. These strategies allow the generation of novel versatile systems that can be employed in many biotechnological or biomedical fields. Here, we review and discuss the most recent papers dealing with the preparation of magnetic CNTs and their application in biomedical and biotechnological fields.

Gigantic magnetic-field-induced polarization and magnetoelectric coupling in a ferrimagnetic oxide CaBaCo 4 O 7

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caignaert, V.; Maignan, A.; Singh, K.

2013-11-01

Below Tc, the single-crystal study of CaBaCo40,, a noncollinear ferrimagnet (Tc = 64 K) with a polar orthorhombic space group (Pbn21) between 4 and 293 K, shows a large change inthe electric polarization along its c axis reaching !!iP = 17 mC/m2 at 10 K. At 62.5 K, a magnetic-field-driven giant variation inpolarization P(9 T) - P(O T) = 8 mC/m2 is observed. Moreover, the present magnetoelectric measurements are fully consistent withthe m'm2' magnetic point group. This ferrimagnetic oxide, which belongs to the "114" structural family, opens an avenue for the search for new magnetoelectrics.

All electrical propagating spin wave spectroscopy with broadband wavevector capability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ciubotaru, F., E-mail: Florin.Ciubotaru@imec.be; KU Leuven, Departement Electrotechniek; Devolder, T.

2016-07-04

We developed an all electrical experiment to perform the broadband phase-resolved spectroscopy of propagating spin waves in micrometer sized thin magnetic stripes. The magnetostatic surface spin waves are excited and detected by scaled down to 125 nm wide inductive antennas, which award ultra broadband wavevector capability. The wavevector selection can be done by applying an excitation frequency above the ferromagnetic resonance. Wavevector demultiplexing is done at the spin wave detector thanks to the rotation of the spin wave phase upon propagation. A simple model accounts for the main features of the apparatus transfer functions. Our approach opens an avenue for themore » all electrical study of wavevector-dependent spin wave properties including dispersion spectra or non-reciprocal propagation.« less

Laser spectroscopy of a halocarbocation in the gas phase: CH2I+.

PubMed

Tao, Chong; Mukarakate, Calvin; Reid, Scott A

2006-07-26

We report the first gas-phase observation of the electronic spectrum of a simple halocarbocation, CH2I+. The ion was generated rotationally cold (Trot approximately 20 K) using pulsed discharge methods and was detected via laser spectroscopy. The identity of the spectral carrier was confirmed by modeling the rotational contour observed in the excitation spectra and by comparison of ground state vibrational frequencies determined by single vibronic level emission spectroscopy with Density Functional Theory (DFT) predictions. The transition was assigned as 3A1 <-- X1A1. This initial detection of the electronic spectrum of a halocarbocation in the gas phase should open new avenues for study of the structure and reactivity of these important ions.

Local food activity in the Republic of Ireland and Great Britain.

PubMed

Ricketts Hein, Jane; Watts, David

2010-01-01

Recent changes in local food supply systems have attracted substantial research interest, but little consideration has been paid to exactly where they occur. This article combines data from three studies to compare local food system development in England, Wales, Scotland and Ireland using a single index of food relocalisation, thereby exploring the usefulness of the Index across different social and political contexts. Four diagnostic indicators suggest that local food systems in the south west of Ireland and Britain are particularly well developed. The Index itself is a useful tool for making international comparisons, being easy to replicate and allowing the integration of different data sets. Perhaps its greatest utility is that it opens up new avenues for further research.

Open Knee: Open Source Modeling and Simulation in Knee Biomechanics.

PubMed

Erdemir, Ahmet

2016-02-01

Virtual representations of the knee joint can provide clinicians, scientists, and engineers the tools to explore mechanical functions of the knee and its tissue structures in health and disease. Modeling and simulation approaches such as finite element analysis also provide the possibility to understand the influence of surgical procedures and implants on joint stresses and tissue deformations. A large number of knee joint models are described in the biomechanics literature. However, freely accessible, customizable, and easy-to-use models are scarce. Availability of such models can accelerate clinical translation of simulations, where labor-intensive reproduction of model development steps can be avoided. Interested parties can immediately utilize readily available models for scientific discovery and clinical care. Motivated by this gap, this study aims to describe an open source and freely available finite element representation of the tibiofemoral joint, namely Open Knee, which includes the detailed anatomical representation of the joint's major tissue structures and their nonlinear mechanical properties and interactions. Three use cases illustrate customization potential of the model, its predictive capacity, and its scientific and clinical utility: prediction of joint movements during passive flexion, examining the role of meniscectomy on contact mechanics and joint movements, and understanding anterior cruciate ligament mechanics. A summary of scientific and clinically directed studies conducted by other investigators are also provided. The utilization of this open source model by groups other than its developers emphasizes the premise of model sharing as an accelerator of simulation-based medicine. Finally, the imminent need to develop next-generation knee models is noted. These are anticipated to incorporate individualized anatomy and tissue properties supported by specimen-specific joint mechanics data for evaluation, all acquired in vitro from varying age groups and pathological states. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A Clustering-Based Approach to Enriching Code Foraging Environment.

PubMed

Niu, Nan; Jin, Xiaoyu; Niu, Zhendong; Cheng, Jing-Ru C; Li, Ling; Kataev, Mikhail Yu

2016-09-01

Developers often spend valuable time navigating and seeking relevant code in software maintenance. Currently, there is a lack of theoretical foundations to guide tool design and evaluation to best shape the code base to developers. This paper contributes a unified code navigation theory in light of the optimal food-foraging principles. We further develop a novel framework for automatically assessing the foraging mechanisms in the context of program investigation. We use the framework to examine to what extent the clustering of software entities affects code foraging. Our quantitative analysis of long-lived open-source projects suggests that clustering enriches the software environment and improves foraging efficiency. Our qualitative inquiry reveals concrete insights into real developer's behavior. Our research opens the avenue toward building a new set of ecologically valid code navigation tools.

Pollutant Concentrations in Street Canyons of Different Aspect Ratio with Avenues of Trees for Various Wind Directions

NASA Astrophysics Data System (ADS)

Gromke, Christof; Ruck, Bodo

2012-07-01

This study summarizes the effects of avenues of trees in urban street canyons on traffic pollutant dispersion. We describe various wind-tunnel experiments with different tree-avenue models in combination with variations in street-canyon aspect ratio W/ H (with W the street-canyon width and H the building height) and approaching wind direction. Compared to tree-free street canyons, in general, higher pollutant concentrations are found. Avenues of trees do not suppress canyon vortices, although the air ventilation in canyons is hindered significantly. For a perpendicular wind direction, increases in wall-average and wall-maximum concentrations at the leeward canyon wall and decreases in wall-average concentrations at the windward wall are found. For oblique and perpendicular wind directions, increases at both canyon walls are obtained. The strongest effects of avenues of trees on traffic pollutant dispersion are observed for oblique wind directions for which also the largest concentrations at the canyon walls are found. Thus, the prevailing assumption that attributes the most harmful dispersion conditions to a perpendicular wind direction does not hold for street canyons with avenues of trees. Furthermore, following dimensional analysis, an estimate of the normalized wall-maximum traffic pollutant concentration in street canyons with avenues of trees is derived.

Biological materials by design.

PubMed

Qin, Zhao; Dimas, Leon; Adler, David; Bratzel, Graham; Buehler, Markus J

2014-02-19

In this topical review we discuss recent advances in the use of physical insight into the way biological materials function, to design novel engineered materials 'from scratch', or from the level of fundamental building blocks upwards and by using computational multiscale methods that link chemistry to material function. We present studies that connect advances in multiscale hierarchical material structuring with material synthesis and testing, review case studies of wood and other biological materials, and illustrate how engineered fiber composites and bulk materials are designed, modeled, and then synthesized and tested experimentally. The integration of experiment and simulation in multiscale design opens new avenues to explore the physics of materials from a fundamental perspective, and using complementary strengths from models and empirical techniques. Recent developments in this field illustrate a new paradigm by which complex material functionality is achieved through hierarchical structuring in spite of simple material constituents.

Induced Pluripotent Stem Cell-Derived Endothelial Cells in Insulin Resistance and Metabolic Syndrome.

PubMed

Carcamo-Orive, Ivan; Huang, Ngan F; Quertermous, Thomas; Knowles, Joshua W

2017-11-01

Insulin resistance leads to a number of metabolic and cellular abnormalities including endothelial dysfunction that increase the risk of vascular disease. Although it has been particularly challenging to study the genetic determinants that predispose to abnormal function of the endothelium in insulin-resistant states, the possibility of deriving endothelial cells from induced pluripotent stem cells generated from individuals with detailed clinical phenotyping, including accurate measurements of insulin resistance accompanied by multilevel omic data (eg, genetic and genomic characterization), has opened new avenues to study this relationship. Unfortunately, several technical barriers have hampered these efforts. In the present review, we summarize the current status of induced pluripotent stem cell-derived endothelial cells for modeling endothelial dysfunction associated with insulin resistance and discuss the challenges to overcoming these limitations. © 2017 American Heart Association, Inc.

Pathology and Molecular Genetics of Pancreatic Neoplasms

PubMed Central

Wood, Laura D.; Hruban, Ralph H.

2014-01-01

Cancer is fundamentally a genetic disease caused by the ac cumulation of somatic mutations in oncogenes and tumor suppressor genes. In the last decade, rapid advances in sequencing and bioinformatic technology led to an explosion in sequencing studies of cancer genomes, greatly expanding our knowledge of the genetic changes underlying a variety of tumor types. Several of these studies of cancer genomes have focused on pancreatic neoplasms, and cancers from the pancreas are some of the best characterized tumors at the genetic level. Pancreatic neoplasms encompass a wide array of clinical diseases, from benign cysts to deadly cancers, and the genetic alterations underlying neoplasms of the pancreas are similarly diverse. This new knowledge of pancreatic cancer genomes has deepened our understanding of tumorigenesis in the pancreas and has opened several promising new avenues for novel diagnostics and therapeutics. PMID:23187835

Polarization of submillimetre lines from interstellar medium

NASA Astrophysics Data System (ADS)

Zhang, Heshou; Yan, Huirong

2018-04-01

Magnetic fields play important roles in many astrophysical processes. However, there is no universal diagnostic for the magnetic fields in the interstellar medium (ISM) and each magnetic tracer has its limitation. Any new detection method is thus valuable. Theoretical studies have shown that submillimetre fine-structure lines are polarized due to atomic alignment by ultraviolet photon-excitation, which opens up a new avenue to probe interstellar magnetic fields. We will, for the first time, perform synthetic observations on the simulated three-dimensional ISM to demonstrate the measurability of the polarization of submillimetre atomic lines. The maximum polarization for different absorption and emission lines expected from various sources, including star-forming regions are provided. Our results demonstrate that the polarization of submillimetre atomic lines is a powerful magnetic tracer and add great value to the observational studies of the submilimetre astronomy.

Epigenetic regulation of open chromatin in pluripotent stem cells

PubMed Central

Kobayashi, Hiroshi; Kikyo, Nobuaki

2014-01-01

The recent progress in pluripotent stem cell research has opened new avenues of disease modeling, drug screening, and transplantation of patient-specific tissues that had been unimaginable until a decade ago. The central mechanism underlying pluripotency is epigenetic gene regulation; the majority of cell signaling pathways, both extracellular and cytoplasmic, eventually alter the epigenetic status of their target genes during the process of activating or suppressing the genes to acquire or maintain pluripotency. It has long been thought that the chromatin of pluripotent stem cells is globally open to enable the timely activation of essentially all genes in the genome during differentiation into multiple lineages. The current article reviews descriptive observations and the epigenetic machinery relevant to what is supposed to be globally open chromatin in pluripotent stem cells. This includes microscopic appearance, permissive gene transcription, chromatin remodeling complexes, histone modifications, DNA methylation, noncoding RNAs, dynamic movement of chromatin proteins, nucleosome accessibility and positioning, and long-range chromosomal interactions. Detailed analyses of each element, however, have revealed that the globally open chromatin hypothesis is not necessarily supported by some of the critical experimental evidence, such as genome-wide nucleosome accessibility and nucleosome positioning. Further understanding of the epigenetic gene regulation is expected to determine the true nature of the so-called globally open chromatin in pluripotent stem. PMID:24695097

Model-based analysis of coupled equilibrium-kinetic processes: indirect kinetic studies of thermodynamic parameters using the dynamic data.

PubMed

Emami, Fereshteh; Maeder, Marcel; Abdollahi, Hamid

2015-05-07

Thermodynamic studies of equilibrium chemical reactions linked with kinetic procedures are mostly impossible by traditional approaches. In this work, the new concept of generalized kinetic study of thermodynamic parameters is introduced for dynamic data. The examples of equilibria intertwined with kinetic chemical mechanisms include molecular charge transfer complex formation reactions, pH-dependent degradation of chemical compounds and tautomerization kinetics in micellar solutions. Model-based global analysis with the possibility of calculating and embedding the equilibrium and kinetic parameters into the fitting algorithm has allowed the complete analysis of the complex reaction mechanisms. After the fitting process, the optimal equilibrium and kinetic parameters together with an estimate of their standard deviations have been obtained. This work opens up a promising new avenue for obtaining equilibrium constants through the kinetic data analysis for the kinetic reactions that involve equilibrium processes.

Puberty and the Education of Girls*

PubMed Central

CAVANAGH, SHANNON E.; RIEGLE-CRUMB, CATHERINE; CROSNOE, ROBERT

2010-01-01

This study extends previous research on the social psychological implications of pubertal timing to education by applying a life course framework to data from the National Longitudinal Study of Adolescent Health and from the Adolescent Health and Academic Achievement Study. Early pubertal timing, which has previously been associated with major social psychological changes in girls' lives during middle school, predicted girls' grade point average and probability of course failure at the start of high school. Because of this initial failure during the high school transition, it also predicted their probability of dropping out of high school, and, among those who graduated, their grade point average at the end of high school. Such research demonstrates one way in which the immediate social psychological risk of early pubertal timing, measured as the age at menarche, translates into long-term disadvantage for girls, thereby opening up new avenues of research for social psychologists interested in youth development, health, and education. PMID:20216926

A toolbox to explore the mechanics of living embryonic tissues

PubMed Central

Campàs, Otger

2016-01-01

The sculpting of embryonic tissues and organs into their functional morphologies involves the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in vitro work, complemented by some in vivo studies, have shown the relevance of mechanical cues in the control of cell behaviors that are central to developmental processes, but the lack of methodologies enabling precise, quantitative measurements of mechanical cues in vivo have hindered our understanding of the role of mechanics in embryonic development. Several methodologies are starting to enable quantitative studies of mechanics in vivo and in situ, opening new avenues to explore how mechanics contributes to shaping embryonic tissues and how it affects cell behavior within developing embryos. Here we review the present methodologies to study the role of mechanics in living embryonic tissues, considering their strengths and drawbacks as well as the conditions in which they are most suitable. PMID:27061360

A toolbox to explore the mechanics of living embryonic tissues.

PubMed

Campàs, Otger

2016-07-01

The sculpting of embryonic tissues and organs into their functional morphologies involves the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in vitro work, complemented by some in vivo studies, have shown the relevance of mechanical cues in the control of cell behaviors that are central to developmental processes, but the lack of methodologies enabling precise, quantitative measurements of mechanical cues in vivo have hindered our understanding of the role of mechanics in embryonic development. Several methodologies are starting to enable quantitative studies of mechanics in vivo and in situ, opening new avenues to explore how mechanics contributes to shaping embryonic tissues and how it affects cell behavior within developing embryos. Here we review the present methodologies to study the role of mechanics in living embryonic tissues, considering their strengths and drawbacks as well as the conditions in which they are most suitable. Copyright © 2016 Elsevier Ltd. All rights reserved.

Feasibility Study on 3-D Printing of Metallic Structural Materials with Robotized Laser-Based Metal Additive Manufacturing

NASA Astrophysics Data System (ADS)

Ding, Yaoyu; Kovacevic, Radovan

2016-07-01

Metallic structural materials continue to open new avenues in achieving exotic mechanical properties that are naturally unavailable. They hold great potential in developing novel products in diverse industries such as the automotive, aerospace, biomedical, oil and gas, and defense. Currently, the use of metallic structural materials in industry is still limited because of difficulties in their manufacturing. This article studied the feasibility of printing metallic structural materials with robotized laser-based metal additive manufacturing (RLMAM). In this study, two metallic structural materials characterized by an enlarged positive Poisson's ratio and a negative Poisson's ratio were designed and simulated, respectively. An RLMAM system developed at the Research Center for Advanced Manufacturing of Southern Methodist University was used to print them. The results of the tensile tests indicated that the printed samples successfully achieved the corresponding mechanical properties.

Nuclear transporters in a multinucleated organism: functional and localization analyses in Aspergillus nidulans

PubMed Central

Markina-Iñarrairaegui, Ane; Etxebeste, Oier; Herrero-García, Erika; Araújo-Bazán, Lidia; Fernández-Martínez, Javier; Flores, Jairo A.; Osmani, Stephen A.; Espeso, Eduardo A.

2011-01-01

Nuclear transporters mediate bidirectional macromolecule traffic through the nuclear pore complex (NPC), thus participating in vital processes of eukaryotic cells. A systematic functional analysis in Aspergillus nidulans permitted the identification of 4 essential nuclear transport pathways of a hypothetical number of 14. The absence of phenotypes for most deletants indicates redundant roles for these nuclear receptors. Subcellular distribution studies of these carriers show three main distributions: nuclear, nucleocytoplasmic, and in association with the nuclear envelope. These locations are not specific to predicted roles as exportins or importins but indicate that bidirectional transport may occur coordinately in all nuclei of a syncytium. Coinciding with mitotic NPC rearrangements, transporters dynamically modified their localizations, suggesting supplementary roles to nucleocytoplasmic transport specifically during mitosis. Loss of transportin-SR and Mex/TAP from the nuclear envelope indicates absence of RNA transport during the partially open mitosis of Aspergillus, whereas nucleolar accumulation of Kap121 and Kap123 homologues suggests a role in nucleolar disassembly. This work provides new insight into the roles of nuclear transporters and opens an avenue for future studies of the molecular mechanisms of transport among nuclei within a common cytoplasm, using A. nidulans as a model organism. PMID:21880896

Has the American Public's Interest in Information Related to Relationships Beyond "The Couple" Increased Over Time?

PubMed

Moors, Amy C

2017-01-01

Finding romance, love, and sexual intimacy is a central part of our life experience. Although people engage in romance in a variety of ways, alternatives to "the couple" are largely overlooked in relationship research. Scholars and the media have recently argued that the rules of romance are changing, suggesting that interest in consensual departures from monogamy may become popular as people navigate their long-term coupling. This study utilizes Google Trends to assess Americans' interest in seeking out information related to consensual nonmonogamous relationships across a 10-year period (2006-2015). Using anonymous Web queries from hundreds of thousands of Google search engine users, results show that searches for words related to polyamory and open relationships (but not swinging) have significantly increased over time. Moreover, the magnitude of the correlation between consensual nonmonogamy Web queries and time was significantly higher than popular Web queries over the same time period, indicating this pattern of increased interest in polyamory and open relationships is unique. Future research avenues for incorporating consensual nonmonogamous relationships into relationship science are discussed.

Open Issues in Evolutionary Robotics.

PubMed

Silva, Fernando; Duarte, Miguel; Correia, Luís; Oliveira, Sancho Moura; Christensen, Anders Lyhne

2016-01-01

One of the long-term goals in evolutionary robotics is to be able to automatically synthesize controllers for real autonomous robots based only on a task specification. While a number of studies have shown the applicability of evolutionary robotics techniques for the synthesis of behavioral control, researchers have consistently been faced with a number of issues preventing the widespread adoption of evolutionary robotics for engineering purposes. In this article, we review and discuss the open issues in evolutionary robotics. First, we analyze the benefits and challenges of simulation-based evolution and subsequent deployment of controllers versus evolution on real robotic hardware. Second, we discuss specific evolutionary computation issues that have plagued evolutionary robotics: (1) the bootstrap problem, (2) deception, and (3) the role of genomic encoding and genotype-phenotype mapping in the evolution of controllers for complex tasks. Finally, we address the absence of standard research practices in the field. We also discuss promising avenues of research. Our underlying motivation is the reduction of the current gap between evolutionary robotics and mainstream robotics, and the establishment of evolutionary robotics as a canonical approach for the engineering of autonomous robots.

Approximate quasiparticle correction for calculations of the energy gap in two-dimensional materials

NASA Astrophysics Data System (ADS)

Guilhon, I.; Koda, D. S.; Ferreira, L. G.; Marques, M.; Teles, L. K.

2018-01-01

At the same time that two-dimensional (2D) systems open possibilities for new physics and applications, they present a higher challenge for electronic structure calculations, especially concerning excitations. The achievement of a fast and accurate practical model that incorporates approximate quasiparticle corrections can further open an avenue for more reliable band structure calculations of complex systems such as interactions of 2D materials with substrates or molecules, as well as the formation of van der Waals heterostructures. In this work, we demonstrate that the performance of the fast and parameter-free DFT-1/2 method is comparable with state-of-the-art GW and superior to the HSE06 hybrid functional in the majority set of the 34 different 2D materials studied. Moreover, based on the knowledge of the method and chemical information of the material, we can predict the small number of cases in which the method is not so effective and also provide the best recipe for an optimized DFT-1/2 method based on the electronegativity difference of the bonding atoms.

A new 3D POMOF based on CuI/CuII-bis(triazole) complexes and BW12 Keggin polyoxoanions: Synthesis, characterization and electrochemical properties

NASA Astrophysics Data System (ADS)

Zhang, Yanjun; Fu, Xin; Zhang, Chunjing; Pang, Hainjun; Ma, Huiyuan; Zhao, Xi; Wang, Cheng

2018-02-01

A novel organic-inorganic hybrid compound, {[CuI(btpe)2][CuII2(H2O)2(btpe)2][BW12O40]}·2H2O, (btpe = 1,5-bis(1,2,4-triazol-1-yl)pentane) (1) has been synthesized by hydrothermal reaction, and characterized by elemental analyses, IR spectroscopy, TG and single X-ray diffraction. Compound 1 is composed of α-Keggin type [BW12O40]5- (BW12) polyoxoanions and copper-btpe complexes. The copper-btpe complexes are stagger-packed to form an open framework containing the two kinds of channels with parallelogram-like apertures, in which the BW12 guests are encapsulated into the bigger channels. The electrochemical studies show that 1 has a good electrocatalytic activity towards reduction of hydrogen peroxide (H2O2), thanking to its special porous POMOF structure. The molecular design of 1 not only generates a new POMOF, but also opens a new avenue to the electrocatalytic materials.

Observations on the preparation of sections of dental hard and soft tissues without conventional embedding procedures.

PubMed

Mok, Y C; Fearnhead, R W

1985-09-01

Inexpensive thin copper discs loaded with diamonds embedded in small slits around the periphery, may be used to cut sections from unembedded tooth samples without disrupting the cellular and extracellular components intimately associated with hard tissue interfaces. The tissue may be unfixed, fixed or cut using fixation or dye solutions as the lubricant. The use of these discs therefore opens up new avenues of histochemical investigation of hard tissue unrestricted by those artefacts associated with conventional or traditional methods of preparation.

High yield fabrication of fluorescent nanodiamonds

PubMed Central

Boudou, Jean-Paul; Curmi, Patrick; Jelezko, Fedor; Wrachtrup, Joerg; Aubert, Pascal; Sennour, Mohamed; Balasubramanian, Gopalakrischnan; Reuter, Rolf; Thorel, Alain; Gaffet, Eric

2009-01-01

A new fabrication method to produce homogeneously fluorescent nanodiamonds with high yields is described. The powder obtained by high energy ball milling of fluorescent high pressure, high temperature diamond microcrystals was converted in a pure concentrated aqueous colloidal dispersion of highly crystalline ultrasmall nanoparticles with a mean size less than or equal to 10 nm. The whole fabrication yield of colloidal quasi-spherical nanodiamonds was several orders of magnitude higher than those previously reported starting from microdiamonds. The results open up avenues for the industrial cost-effective production of fluorescent nanodiamonds with well-controlled properties. PMID:19451687

Anatomy of exotic Higgs decays in 2HDM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kling, Felix; No, Jose Miguel; Su, Shufang

Large mass splittings between new scalars in two-Higgs-doublet models (2HDM) open a key avenue to search for these new states via exotic heavy Higgs decays. We discuss in detail the different search channels for these new scalars at the LHC in the presence of a sizable mass splitting, i.e. a hierarchical 2HDM scenario, taking into account the theoretical and experimental constraints. Here, we provide benchmark planes to exploit the complementarity among these searches, analyzing their potential to probe the hierarchical 2HDM parameter space during LHC Run 2.

Chiral selection on inorganic crystalline surfaces

NASA Technical Reports Server (NTRS)

Hazen, Robert M.; Sholl, David S.

2003-01-01

From synthetic drugs to biodegradable plastics to the origin of life, the chiral selection of molecules presents both daunting challenges and significant opportunities in materials science. Among the most promising, yet little explored, avenues for chiral molecular discrimination is adsorption on chiral crystalline surfaces - periodic environments that can select, concentrate and possibly even organize molecules into polymers and other macromolecular structures. Here we review experimental and theoretical approaches to chiral selection on inorganic crystalline surfaces - research that is poised to open this new frontier in understanding and exploiting surface-molecule interactions.

Tuning group-velocity dispersion by optical force.

PubMed

Jiang, Wei C; Lin, Qiang

2013-07-15

We propose an optomechanical approach for dispersion dynamic tuning and microengineering by taking advantage of the optical force in nano-optomechanical structures. Simulations of a suspended coupled silicon waveguide show that the zero-dispersion wavelength can be tuned by 40 nm by an optical pump power of 3 mW. Our approach exhibits great potential for broad applications in dispersion-sensitive processes, which not only offers a new root toward versatile tunable nonlinear photonics but may also open up a great avenue toward a new regime of nonlinear dynamics coupling between nonlinear optical and optomechanical effects.

Anatomy of exotic Higgs decays in 2HDM

NASA Astrophysics Data System (ADS)

Kling, Felix; No, Jose Miguel; Su, Shufang

2016-09-01

Large mass splittings between new scalars in two-Higgs-doublet models (2HDM) open a key avenue to search for these new states via exotic heavy Higgs decays. We discuss in detail the different search channels for these new scalars at the LHC in the presence of a sizable mass splitting, i.e. a hierarchical 2HDM scenario, taking into account the theoretical and experimental constraints. We provide benchmark planes to exploit the complementarity among these searches, analyzing their potential to probe the hierarchical 2HDM parameter space during LHC Run 2.

Manipulating TRPV1 antagonists: how to cool down a hot molecule?

PubMed

Islas, Leon; Szallasi, Arpad

2018-05-05

TRPV1 is a promising pain target. Although a number of small molecule TRPV1 antagonists have been advanced into clinical trials, thus far none has progressed beyond Phase II due to on-target side-effects such as a febrile reaction. In this issue of Acta Physiologica, Romanovsky and colleagues report two TRPV1 antagonists that paradoxically induce hypothermia in experimental animals, potentially opening a new avenue for drug development. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Superlubrication by phonon confinement

NASA Astrophysics Data System (ADS)

Wada, Noriyuki; Ishikawa, Makoto; Shiga, Takuma; Shiomi, Junichiro; Suzuki, Masaru; Miura, Kouji

2018-04-01

The superlubrication described here, involving confined phonons, is easily achievable and very simple because it uses only submicron islands, smaller than the mean free path of the phonons, to confine phonons. We can achieve superlubrication with a friction force of piconewton order at the submicron island. We can call this phononic lubrication or self-lubrication because phonons induced by tip shearing are confined within the submicron islands and decrease the friction during the subsequent sliding. Phonon confinement should make it possible to directly develop applications for lubricants and ultimately to open a novel avenue of tribology.

Anatomy of exotic Higgs decays in 2HDM

DOE PAGES

Kling, Felix; No, Jose Miguel; Su, Shufang

2016-09-16

Large mass splittings between new scalars in two-Higgs-doublet models (2HDM) open a key avenue to search for these new states via exotic heavy Higgs decays. We discuss in detail the different search channels for these new scalars at the LHC in the presence of a sizable mass splitting, i.e. a hierarchical 2HDM scenario, taking into account the theoretical and experimental constraints. Here, we provide benchmark planes to exploit the complementarity among these searches, analyzing their potential to probe the hierarchical 2HDM parameter space during LHC Run 2.

29. SOUTHEAST ACROSS BLACKSMITH SHOP AREA TOWARD TWO CIRCA 1900 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. SOUTHEAST ACROSS BLACKSMITH SHOP AREA TOWARD TWO CIRCA 1900 DRILL PRESSES ALONG THE EAST INTERIOR WALL AT THE NORTHEAST CORNER OF THE FACTORY BUILDING. THE HOODED FORGE IS VISIBLE IN THE LEFT FOREGROUND, SHOWING LADLES USED FOR POURING BABBITT BEARINGS. MOUNTED ON THE WORK BENCH IS THE MAIN CASTING FROM AN ELI WINDMILL, USED AS A JIG TO SUPPORT PARTS DURING THE BABBITT BEARING POURING OPERATION. THE WALL ABOVE THE WORKBENCH SHOWS THE BOARDED-UP OPENING FOR A FORMER WINDOW. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

A place for agent-based models. Comment on "Statistical physics of crime: A review" by M.R. D'Orsogna and M. Perc

NASA Astrophysics Data System (ADS)

Barbaro, Alethea

2015-03-01

Agent-based models have been widely applied in theoretical ecology to explain migrations and other collective animal movements [2,5,8]. As D'Orsogna and Perc have expertly highlighted in [6], the recent emergence of crime modeling has opened another interesting avenue for mathematical investigation. The area of crime modeling is particularly suited to agent-based models, because these models offer a great deal of flexibility within the model and also ease of communication among criminologist, law enforcement and modelers.

GENERAL VIEW LOOKING EAST, CITY FARM LANE OVERPASS OVER THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW LOOKING EAST, CITY FARM LANE OVERPASS OVER THE CONRAIL (RIGHT) AND CSX (LEFT) RIGHT OF WAYS. STRUCTURES IN FRONT OF TRESTLE INCLUDE (LEFT TO RIGHT): STOREHOUSE, CONSTRUCTION WAREHOUSE AND "HOLE IN THE WALL" (ARCH OPENING AT RIGHT). BEHIND BRIDGE ARE: MACHINE SHOP NO. 2, VERTICAL FURNACE BUILDING, AND PIT FURNACES OF THE STRUCTURAL MILL. STACKS OF THE CARRIE FURNACE CAN BE SEEN ACROSS THE RIVER AT RIGHT REAR. - U.S. Steel Homestead Works, Along Monongahela River, north of Eighth Avenue, Homestead, Allegheny County, PA

The Dichotomous Effect of Chronic Stress on Obesity.

PubMed

Razzoli, Maria; Bartolomucci, Alessandro

2016-07-01

Obesity and metabolic diseases are linked to chronic stress and low socioeconomic status. The mechanistic link between stress and obesity has not been clarified, partly due to the inherent complexity exemplified by the bidirectional effect of stress on eating and body weight. Recent studies focusing on adaptive thermogenesis and brown adipose tissue (BAT) function support a dichotomous relation to explain the impact of stress on obesity: stress promotes obesity in the presence of hyperphagia and unchanged BAT function; stress results in weight loss and/or obesity resistance in the presence of hypophagia, or when hyperphagia is associated with BAT recruitment and enhanced thermogenesis. Mechanistically dissecting the bidirectional effects of stress on metabolic outcomes might open new avenues for innovative pharmacotherapies for the treatment of obesity-associated diseases. Copyright © 2016 Elsevier Ltd. All rights reserved.

The dichotomous effect of chronic stress on obesity

PubMed Central

Razzoli, Maria; Bartolomucci, Alessandro

2016-01-01

Obesity and metabolic diseases are linked to chronic stress and low socio-economic status. The mechanistic link between stress and obesity has not been clarified, partly due to the inherent complexity exemplified by the bidirectional effect of stress on eating and body weight. Recent studies focusing on adaptive-thermogenesis and brown adipose tissue (BAT) function support a dichotomous relationship to explain the impact of stress on obesity: stress promotes obesity in the presence of hyperphagia and unchanged BAT function; stress results in weight-loss/obesity-resistance in the presence of hypophagia, or when hyperphagia is associated with BAT recruitment and enhanced thermogenesis. Mechanistically dissecting the bidirectional effects of stress on metabolic outcomes might open new avenues for innovative pharmacotherapies for the treatment of obesity-associated diseases. PMID:27162125

Emotional intervention strategies for dementia-related behavior: a theory synthesis.

PubMed

Yao, Lan; Algase, Donna

2008-04-01

Behavioral disturbances of elders with dementia are prevalent. Yet the science guiding development and testing of effective intervention strategies is limited by rudimentary and often-conflicting theories. Using a theory-synthesis approach conducted within the perspective of the need-driven dementia-compromised behavior model, this article presents the locomoting responses to environment in elders with dementia (LRE-EWD) model. This new model, based on empirical and theoretical evidence, integrates the role of emotion with that of cognition in explicating a person-environment dynamic supporting wandering and other dementia-related disturbances. Included is evidence of the theory's testability and elaboration of its implications. The LRE-EWD model resolves conflicting views and evidence from current research on environmental interventions for behavior disturbances and opens new avenues to advance this field of study and practice.

Turning Participatory Microbiome Research into Usable Data: Lessons from the American Gut Project

PubMed Central

Debelius, Justine W.; Vázquez-Baeza, Yoshiki; McDonald, Daniel; Xu, Zhenjiang; Wolfe, Elaine; Knight, Rob

2016-01-01

The role of the human microbiome is the subject of continued investigation resulting in increased understanding. However, current microbiome research has only scratched the surface of the variety of healthy microbiomes. Public participation in science through crowdsourcing and crowdfunding microbiome research provides a novel opportunity for both participants and investigators. However, turning participatory science into publishable data can be challenging. Clear communication with the participant base and among researchers can ameliorate some challenges. Three major aspects need to be considered: recruitment and ongoing interaction, sample collection, and data analysis. Usable data can be maximized through diligent participant interaction, careful survey design, and maintaining an open source pipeline. While participatory science will complement rather than replace traditional avenues, it presents new opportunities for studies in the microbiome and beyond. PMID:27047589

Turning Participatory Microbiome Research into Usable Data: Lessons from the American Gut Project.

PubMed

Debelius, Justine W; Vázquez-Baeza, Yoshiki; McDonald, Daniel; Xu, Zhenjiang; Wolfe, Elaine; Knight, Rob

2016-03-01

The role of the human microbiome is the subject of continued investigation resulting in increased understanding. However, current microbiome research has only scratched the surface of the variety of healthy microbiomes. Public participation in science through crowdsourcing and crowdfunding microbiome research provides a novel opportunity for both participants and investigators. However, turning participatory science into publishable data can be challenging. Clear communication with the participant base and among researchers can ameliorate some challenges. Three major aspects need to be considered: recruitment and ongoing interaction, sample collection, and data analysis. Usable data can be maximized through diligent participant interaction, careful survey design, and maintaining an open source pipeline. While participatory science will complement rather than replace traditional avenues, it presents new opportunities for studies in the microbiome and beyond.

Constructed Rain Garden Systems for Stormwater Quality Control under Tropical Climates

NASA Astrophysics Data System (ADS)

Mohd Sidek, Lariyah; Elyza Muha, Norshafa; Noor, Nur Asmaliza Md; Basri, Hidayah

2013-06-01

Malaysia has taken an integrated approach to manage storm water that is increasingly becoming a problem in big cities. Rain gardens are recommended as green technology for a new storm water management in Malaysia. The approach is applied in urban planning and design that integrates the total water cycle management into the development process areas. Rain gardens have been effective in reducing peak discharge and consistently reduce the number of storm water pollutants. This paper will examine some of guidelines, laboratory studies and field monitoring that shows great potential and benefit of rain garden. The preliminary results for rain garden performance were reported in this paper. The findings from this research will open avenues for researchers to advance the knowledge in rain garden systems to achieve the sustainable development in Malaysia.

Redox Strategies for Crop Improvement.

PubMed

Kerchev, Pavel; De Smet, Barbara; Waszczak, Cezary; Messens, Joris; Van Breusegem, Frank

2015-11-10

Recently, the agro-biotech industry has been driven by overcoming the limitations imposed by fluctuating environmental stress conditions on crop productivity. A common theme among (a)biotic stresses is the perturbation of the redox homeostasis. As a strategy to engineer stress-tolerant crops, many approaches have been centered on restricting the negative impact of reactive oxygen species (ROS) accumulation. In this study, we discuss the scientific background of the existing redox-based strategies to improve crop performance and quality. In this respect, a special focus goes to summarizing the current patent landscape because this aspect is very often ignored, despite constituting the forefront of applied research. The current increased understanding of ROS acting as signaling molecules has opened new avenues to exploit redox biology for crop improvement required for sustainable food security.

Tuning Fluorescence Direction with Plasmonic Metal–Dielectric– Metal Substrates

PubMed Central

Choudhury, Sharmistha Dutta; Badugu, Ramachandram; Nowaczyk, Kazimierz; Ray, Krishanu; Lakowicz, Joseph R.

2013-01-01

Controlling the emission properties of fluorophores is essential for improving the performance of fluorescence-based techniques in modern biochemical research, medical diagnosis, and sensing. Fluorescence emission is isotropic in nature, which makes it difficult to capture more than a small fraction of the total emission. Metal– dielectric–metal (MDM) substrates, discussed in this Letter, convert isotropic fluorescence into beaming emission normal to the substrate. This improves fluorescence collection efficiency and also opens up new avenues for a wide range of fluorescence-based applications. We suggest that MDM substrates can be readily adapted for multiple uses, such as in microarray formats, for directional fluorescence studies of multiple probes or for molecule-specific sensing with a high degree of spatial control over the fluorescence emission. SECTION: Physical Processes in Nanomaterials and Nanostructures PMID:24013521

*K-means and cluster models for cancer signatures.

PubMed

Kakushadze, Zura; Yu, Willie

2017-09-01

We present *K-means clustering algorithm and source code by expanding statistical clustering methods applied in https://ssrn.com/abstract=2802753 to quantitative finance. *K-means is statistically deterministic without specifying initial centers, etc. We apply *K-means to extracting cancer signatures from genome data without using nonnegative matrix factorization (NMF). *K-means' computational cost is a fraction of NMF's. Using 1389 published samples for 14 cancer types, we find that 3 cancers (liver cancer, lung cancer and renal cell carcinoma) stand out and do not have cluster-like structures. Two clusters have especially high within-cluster correlations with 11 other cancers indicating common underlying structures. Our approach opens a novel avenue for studying such structures. *K-means is universal and can be applied in other fields. We discuss some potential applications in quantitative finance.

Exploitation of Food Industry Waste for High-Value Products.

PubMed

Ravindran, Rajeev; Jaiswal, Amit K

2016-01-01

A growing global population leads to an increasing demand for food production and the processing industry associated with it and consequently the generation of large amounts of food waste. This problem is intensified due to slow progress in the development of effective waste management strategies and measures for the proper treatment and disposal of waste. Food waste is a reservoir of complex carbohydrates, proteins, lipids, and nutraceuticals and can form the raw materials for commercially important metabolites. The current legislation on food waste treatment prioritises the prevention of waste generation and least emphasises disposal. Recent valorisation studies for food supply chain waste opens avenues to the production of biofuels, enzymes, bioactive compounds, biodegradable plastics, and nanoparticles among many other molecules. Copyright © 2015 Elsevier Ltd. All rights reserved.

Does self-complexity moderate the effects of exposure to political violence for adolescents?

PubMed

Slone, Michelle; Roziner, Ilan

2013-01-01

This study examined the moderating role of self-complexity (SC) on well-being (WB) and psychopathology among Israeli adolescents exposed to the Second Lebanon War (2006). Adolescents (N=584, mean age 16.41) completed a SC measure, Political and Negative Life Events (NLE) scales, Brief Symptom Inventory and Satisfaction with Life Scale. The theoretical model analyzed the function of SC as a moderator of exposure effects to political life events (PLE), while controlling for general NLE. Results corroborated the model with SC moderating the effects of the war-related PLE. Adolescents with low SC are at risk for damaged WB and psychiatric consequences from political violence exposure. This opens a diagnostic avenue for identification of at-risk adolescents in this socio-political context toward whom clinical programs should be directed.

Unraveling heavy oil desulfurization chemistry: targeting clean fuels.

PubMed

Choudhary, Tushar V; Parrott, Stephen; Johnson, Byron

2008-03-15

The sulfur removal chemistry of heavy oils has been unraveled by systematically investigating several heavy oils with an extremely wide range of properties. The heavy oil feed and product properties have been characterized by advanced analytical methods, and these properties have been related to the sulfur conversion data observed in pilot hydrotreating units. These studies coupled with kinetic treatment of the data have revealed that the desulfurization chemistry of heavy oils is essentially controlled by the strongly inhibiting three and larger ring aromatic hydrocarbon content and surprisingly not by the content of the "hard-to-remove" sulfur compounds. Such enhanced understanding of the heavy oil sulfur removal is expected to open new avenues for catalyst/process optimization for heavy oil desulfurization and thereby assist the efficent production of clean transporation fuels.

The Gut Microbiome: A New Frontier in Autism Research

PubMed Central

Mulle, Jennifer G.; Sharp, William G.; Cubells, Joseph F.

2013-01-01

The human gut harbors a complex community of microbes that profoundly influence many aspects of growth and development, including development of the nervous system. Advances in high-throughput DNA sequencing methods have led to rapidly expanding knowledge about this gut microbiome. Here, we review fundamental emerging data on the human gut microbiome, with a focus on potential interactions between the microbiome and autism spectrum disorders (ASD) and consider research on atypical patterns of feeding and nutrition in ASD and how they might interact with the microbiome. Finally we selectively survey results from studies in rodents on the impact of the microbiome on neurobehavioral development. The evidence reviewed here suggests that a deeper understanding of the gut microbiome could open up new avenues of research on ASD, including potential novel treatment strategies. PMID:23307560

80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT GUN HILL STATION. 7TH AVENUE EL EXPRESS IS VISIBLE ABOVE THE 3RD AVENUE EL WHICH JOINED ONTO THE SAME STRUCTURE AT GUN HILL ROAD. NOTE: GUN HILL ROAD IS THE NORTH TERMINUS OF THE 3RD AVENUE ELEVATED. TRAINS DID NOT CARRY PASSENGERS BEYOND THIS POINT, ALTHOUGH THE 3RD AVENUE TRACK DID EXTEND FURTHER NORTH FOR SWITCHING PURPOSES AND INTO THE YARDS. - Interborough Rapid Transit Company, Third Avenue Elevated Line, Borough of the Bronx, New York County, NY

Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review)

PubMed Central

Ilie, Mihaela Adriana; Caruntu, Constantin; Zurac, Sabina; Neagu, Monica; Constantin, Carolina; Branisteanu, Daciana Elena; Voiculescu, Vlad; Mamoulakis, Charalampos; Tzanakakis, George; Spandidos, Demetrios A.

2018-01-01

Human papilloma viruses (HPV) are a small group of non-enveloped viruses belonging to the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles consist of a genome in the form of a circular double-stranded DNA, encompassing eight open reading frames, as well as a non-enveloped icosahedral capsid. HPV infection is considered the most common sexually transmitted disease in both sexes and is strongly implicated in the pathogenesis of different types of cancer. ‘High-risk’ mucosal HPV types, predominantly types 16, 18, 31, 33 and 35, are associated with most cervical, penile, vulvar, vaginal, anal, oropharyngeal cancers and pre-cancers. Screening for HPV is necessary for the prognosis and for determining treatment strategies for cancer. Novel HPV markers, including proteomic and genomic markers, as well as anti-papillomavirus vaccines are currently available. The aim of this comprehensive review was to thoroughly present the updated information on virus development, cancer occurrence, treatment and prevention strategies, in an attempt to shed further light into the field, including novel research avenues. PMID:29393378

Reflected wavefront manipulation based on ultrathin planar acoustic metasurfaces

PubMed Central

Li, Yong; Liang, Bin; Gu, Zhong-ming; Zou, Xin-ye; Cheng, Jian-chun

2013-01-01

The introduction of metasurfaces has renewed the Snell's law and opened up new degrees of freedom to tailor the optical wavefront at will. Here, we theoretically demonstrate that the generalized Snell's law can be achieved for reflected acoustic waves based on ultrathin planar acoustic metasurfaces. The metasurfaces are constructed with eight units of a solid structure to provide discrete phase shifts covering the full 2π span with steps of π/4 by coiling up the space. By careful selection of the phase profiles in the transverse direction of the metasurfaces, some fascinating wavefront engineering phenomena are demonstrated, such as anomalous reflections, conversion of propagating waves into surface waves, planar aberration-free lens and nondiffracting Bessel beam generated by planar acoustic axicon. Our results could open up a new avenue for acoustic wavefront engineering and manipulations. PMID:23986034

7. View (looking west) of the second floor corridor in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. View (looking west) of the second floor corridor in the south segment of building. The second floor was designed for residential rental rooms. The guardrail, balusters, newel posts, and handrail, as well as the two upper-level door openings with transoms, are original features. The doors, proper, are nonoriginal and probably were installed when the second floor was converted to office use. The pair of doors (one leaf is open and one is closed) is located at the intermediate stair landing. The original exterior doorway (without a door) is located at the bottom of the stair. The upper-level door without a transom is nonoriginal, as are the floor tile and wall paneling. At the time of documentation a suspended ceiling and duct were removed to ... - Stroud Building, 31-33 North Central Avenue, Phoenix, Maricopa County, AZ

Synthesis of magnetic microtubes decorated with nanowires and cells

NASA Astrophysics Data System (ADS)

Pomar, C. Diaz; Martinho, H.; Ferreira, F. F.; Goia, T. S.; Rodas, A. C. D.; Santos, S. F.; Souza, J. A.

2018-04-01

Antiferromagnetic and ferrimagnetic microtubes decorated with nanowires have been obtained during thermal oxidation process, which was assisted by in situ electrical resistivity measurements. The synthesis route including heat treatment and electrical current along with growth mechanism are presented. This simple method and the ability to tune in the magnetic moment of the obtained microtubes going from a nonmagnetic-like to a large magnetization saturation open an avenue for interesting applications. In vitro experiments involving adherence, migration, and proliferation of fibroblasts cell culture on the surface of the microtubes indicated the absence of cytotoxicity for this material. We have also calculated both torque and driving magnetic force for these microtubes with nanowires and cells as a function of external magnetic field gradient which were found to be robust opening the possibility for magnetic bio micro-robot device fabrication and application in biotechnology.

Time- and energy-efficient solution combustion synthesis of binary metal tungstate nanoparticles with enhanced photocatalytic activity.

PubMed

Thomas, Abegayl; Janáky, Csaba; Samu, Gergely F; Huda, Muhammad N; Sarker, Pranab; Liu, J Ping; van Nguyen, Vuong; Wang, Evelyn H; Schug, Kevin A; Rajeshwar, Krishnan

2015-05-22

In the search for stable and efficient photocatalysts beyond TiO2 , the tungsten-based oxide semiconductors silver tungstate (Ag2 WO4 ), copper tungstate (CuWO4 ), and zinc tungstate (ZnWO4 ) were prepared using solution combustion synthesis (SCS). The tungsten precursor's influence on the product was of particular relevance to this study, and the most significant effects are highlighted. Each sample's photocatalytic activity towards methyl orange degradation was studied and benchmarked against their respective commercial oxide sample obtained by solid-state ceramic synthesis. Based on the results herein, we conclude that SCS is a time- and energy-efficient method to synthesize crystalline binary tungstate nanomaterials even without additional excessive heat treatment. As many of these photocatalysts possess excellent photocatalytic activity, the discussed synthetic strategy may open sustainable materials chemistry avenues to solar energy conversion and environmental remediation. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Marine Microbiological Enzymes: Studies with Multiple Strategies and Prospects.

PubMed

Wang, Yan; Song, Qinghao; Zhang, Xiao-Hua

2016-09-22

Marine microorganisms produce a series of promising enzymes that have been widely used or are potentially valuable for our daily life. Both classic and newly developed biochemistry technologies have been broadly used to study marine and terrestrial microbiological enzymes. In this brief review, we provide a research update and prospects regarding regulatory mechanisms and related strategies of acyl-homoserine lactones (AHL) lactonase, which is an important but largely unexplored enzyme. We also detail the status and catalytic mechanism of the main types of polysaccharide-degrading enzymes that broadly exist among marine microorganisms but have been poorly explored. In order to facilitate understanding, the regulatory and synthetic biology strategies of terrestrial microorganisms are also mentioned in comparison. We anticipate that this review will provide an outline of multiple strategies for promising marine microbial enzymes and open new avenues for the exploration, engineering and application of various enzymes.

Atomic force microscopy and spectroscopy to probe single membrane proteins in lipid bilayers.

PubMed

Sapra, K Tanuj

2013-01-01

The atomic force microscope (AFM) has opened vast avenues hitherto inaccessible to the biological scientist. The high temporal (millisecond) and spatial (nanometer) resolutions of the AFM are suited for studying many biological processes in their native conditions. The AFM cantilever stylus is aptly termed as a "lab on a tip" owing to its versatility as an imaging tool as well as a handle to manipulate single bonds and proteins. Recent examples assert that the AFM can be used to study the mechanical properties and monitor processes of single proteins and single cells, thus affording insight into important mechanistic details. This chapter specifically focuses on practical and analytical protocols of single-molecule AFM methodologies related to high-resolution imaging and single-molecule force spectroscopy of membrane proteins. Both these techniques are operator oriented, and require specialized working knowledge of the instrument, theoretical, and practical skills.

Past-focused environmental comparisons promote proenvironmental outcomes for conservatives

PubMed Central

Baldwin, Matthew; Lammers, Joris

2016-01-01

Conservatives appear more skeptical about climate change and global warming and less willing to act against it than liberals. We propose that this unwillingness could result from fundamental differences in conservatives’ and liberals’ temporal focus. Conservatives tend to focus more on the past than do liberals. Across six studies, we rely on this notion to demonstrate that conservatives are positively affected by past- but not by future-focused environmental comparisons. Past comparisons largely eliminated the political divide that separated liberal and conservative respondents’ attitudes toward and behavior regarding climate change, so that across these studies conservatives and liberals were nearly equally likely to fight climate change. This research demonstrates how psychological processes, such as temporal comparison, underlie the prevalent ideological gap in addressing climate change. It opens up a promising avenue to convince conservatives effectively of the need to address climate change and global warming. PMID:27956619

Binding of small molecules at interface of protein-protein complex - A newer approach to rational drug design.

PubMed

Gurung, A B; Bhattacharjee, A; Ajmal Ali, M; Al-Hemaid, F; Lee, Joongku

2017-02-01

Protein-protein interaction is a vital process which drives many important physiological processes in the cell and has also been implicated in several diseases. Though the protein-protein interaction network is quite complex but understanding its interacting partners using both in silico as well as molecular biology techniques can provide better insights for targeting such interactions. Targeting protein-protein interaction with small molecules is a challenging task because of druggability issues. Nevertheless, several studies on the kinetics as well as thermodynamic properties of protein-protein interactions have immensely contributed toward better understanding of the affinity of these complexes. But, more recent studies on hot spots and interface residues have opened up new avenues in the drug discovery process. This approach has been used in the design of hot spot based modulators targeting protein-protein interaction with the objective of normalizing such interactions.

Polysaccharide metallohydrogel obtained from Salecan and trivalent chromium: Synthesis and characterization.

PubMed

Su, Ting; Qi, Xiaoliang; Zuo, Gancheng; Pan, Xihao; Zhang, Jianfa; Han, Zhiwei; Dong, Wei

2018-02-01

Here, a new kind of Salecan derived polysaccharide metallohydrogel was reported. Successful fabrication of Salecan metallohydrogel was verified by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and rheological measurements. Scanning electron microscope investigations have been conducted to elucidate the morphology of Salecan/Cr 3+ gel (SCgel). We found that the pore size of metallohydrogel can be tailored by adjusting the Cr 3+ dose during gel formation. After that, swelling and de-swelling behaviors were systematically studied. The increasing of chromium ion concentration and the presence of saline solutions will cause the decrease of swelling percentage. It is assumed that the decreasing hydrophilicity of Salecan, the increase of crosslinking density, and the complexation of the carboxylate group with saline ions are the main syneresis mechanisms. Altogether, this study opens a new avenue to prapare Salecan-based hydrogel. Copyright © 2017 Elsevier Ltd. All rights reserved.

Tracing Magnetic Fields With The Polarization Of Submillimeter Lines

NASA Astrophysics Data System (ADS)

Zhang, Heshou; Yan, Huirong

2017-10-01

Magnetic fields play important roles in many astrophysical processes. However, there is no universal diagnostic for the magnetic fields in the interstellar medium (ISM) and each magnetic tracer has its limitation. Any new detection method is thus valuable. Theoretical studies have shown that submillimeter fine-structure lines are polarized due to atomic alignment by Ultraviolet (UV) photon-excitation, which opens up a new avenue to probe interstellar magnetic fields. The method is applicable to all radiative-excitation dominant region, e.g., H II Regions, PDRs. The polarization of the submillimeter fine-structure lines induced by atomic alignment could be substantial and the applicability of using the spectro-polarimetry of atomic lines to trace magnetic fields has been supported by synthetic observations of simulated ISM in our recent paper. Our results demonstrate that the polarization of submillimeter atomic lines is a powerful magnetic tracer and add great value to the observational studies of the submilimeter astronomy.

Large-Scale Fluorescence Calcium-Imaging Methods for Studies of Long-Term Memory in Behaving Mammals

PubMed Central

Jercog, Pablo; Rogerson, Thomas; Schnitzer, Mark J.

2016-01-01

During long-term memory formation, cellular and molecular processes reshape how individual neurons respond to specific patterns of synaptic input. It remains poorly understood how such changes impact information processing across networks of mammalian neurons. To observe how networks encode, store, and retrieve information, neuroscientists must track the dynamics of large ensembles of individual cells in behaving animals, over timescales commensurate with long-term memory. Fluorescence Ca2+-imaging techniques can monitor hundreds of neurons in behaving mice, opening exciting avenues for studies of learning and memory at the network level. Genetically encoded Ca2+ indicators allow neurons to be targeted by genetic type or connectivity. Chronic animal preparations permit repeated imaging of neural Ca2+ dynamics over multiple weeks. Together, these capabilities should enable unprecedented analyses of how ensemble neural codes evolve throughout memory processing and provide new insights into how memories are organized in the brain. PMID:27048190

Free energy landscape and localization of nanoparticles at block copolymer model defects.

PubMed

Kim, Yongjoo; Chen, Hsieh; Alexander-Katz, Alfredo

2014-05-14

Nanoparticle localization in block copolymer model defects is studied using self-consistent field theory simulations. In particular we study the nanoparticle free energy landscape for three different model defects: X, T, Y shape defects. Our results indicate that nanoparticles can be strongly bound to certain locations in these defects. The symmetry of the defects affects in a non-trivial fashion the "stiffness of the trap", with the X shape defect displaying the deepest energy well. The T and Y defects exhibit orientations along which the potential energy well is rather shallow. Furthermore, we find that the free energy well is tunable by the size of the nanoparticles. Our results help to explain recent experimental observations in block copolymer templated assembly of nanoparticles. Furthermore, they may open new avenues to assemble arbitrary heterogeneous patterns with precise nanoparticle positions by carefully controlling the morphology of a block copolymer system by using directed self-assembly techniques.

Metamorphic records of multiple seismic cycles during subduction

PubMed Central

Hacker, Bradley R.; Seward, Gareth G. E.; Kelley, Chris S.

2018-01-01

Large earthquakes occur in rocks undergoing high-pressure/low-temperature metamorphism during subduction. Rhythmic major-element zoning in garnet is a common product of such metamorphism, and one that must record a fundamental subduction process. We argue that rhythmic major-element zoning in subduction zone garnets from the Franciscan Complex, California, developed in response to growth-dissolution cycles driven by pressure pulses. Using electron probe microanalysis and novel techniques in Raman and synchrotron Fourier transform infrared microspectroscopy, we demonstrate that at least four such pressure pulses, of magnitude 100–350 MPa, occurred over less than 300,000 years. These pressure magnitude and time scale constraints are most consistent with the garnet zoning having resulted from periodic overpressure development-dissipation cycles, related to pore-fluid pressure fluctuations linked to earthquake cycles. This study demonstrates that some metamorphic reactions can track individual earthquake cycles and thereby opens new avenues to the study of seismicity. PMID:29568800

Solar Light Responsive Photocatalytic Activity of Reduced Graphene Oxide-Zinc Selenide Nanocomposite

NASA Astrophysics Data System (ADS)

Chakraborty, Koushik; Ibrahim, Sk; Das, Poulomi; Ghosh, Surajit; Pal, Tanusri

2017-10-01

Solution processable reduced graphene oxide-zinc selenide (RGO-ZnSe) nanocomposite has been successfully synthesized by an easy one-pot single-step solvothermal reaction. The RGO-ZnSe composite was characterized structurally and morphologically by the study of XRD analysis, SEM and TEM imaging. Reduction in graphene oxide was confirmed by FTIR spectroscopy analysis. Photocatalytic efficiency of RGO-ZnSe composite was investigated toward the degradation of Rhodamine B under solar light irradiation. Our study indicates that the RGO-ZnSe composite is catalytically more active compared to the controlled-ZnSe under the solar light illumination. Here, RGO plays an important role for photoinduced charge separation and subsequently hinders the electron-hole recombination probability that consequently enhances photocatalytic degradation efficiency. We expect that this type of RGO-based optoelectronics materials opens up a new avenue in the field of photocatalytic degradation of different organic water pollutants.

Combined baseline and one-month changes in big endothelin-1 and brain natriuretic peptide plasma concentrations predict clinical outcomes in patients with left ventricular dysfunction after acute myocardial infarction: Insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study.

PubMed

Olivier, A; Girerd, N; Michel, J B; Ketelslegers, J M; Fay, R; Vincent, J; Bramlage, P; Pitt, B; Zannad, F; Rossignol, P

2017-08-15

Increased levels of neuro-hormonal biomarkers predict poor prognosis in patients with acute myocardial infarction (AMI) complicated by left ventricular systolic dysfunction (LVSD). The predictive value of repeated (one-month interval) brain natriuretic peptides (BNP) and big-endothelin 1 (BigET-1) measurements were investigated in patients with LVSD after AMI. In a sub-study of the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS trial), BNP and BigET-1 were measured at baseline and at 1month in 476 patients. When included in the same Cox regression model, baseline BNP (p=0.0003) and BigET-1 (p=0.026) as well as the relative changes (after 1month) from baseline in BNP (p=0.049) and BigET-1 (p=0.045) were predictive of the composite of cardiovascular death or hospitalization for worsening heart failure. Adding baseline and changes in BigET-1 to baseline and changes in BNP led to a significant increase in prognostic reclassification as assessed by integrated discrimination improvement index (5.0%, p=0.01 for the primary endpoint). Both increased baseline and changes after one month in BigET-1 concentrations were shown to be associated with adverse clinical outcomes, independently from BNP baseline levels and one month changes, in patients after recent AMI complicated with LVSD. This novel result may be of clinical interest since such combined biomarker assessment could improve risk stratification and open new avenues for biomarker-guided targeted therapies. In the present study, we report for the first time in a population of patients with reduced LVEF after AMI and signs or symptoms of congestive HF, that increased baseline values of BNP and BigET-1 as well as a further rise of these markers over the first month after AMI, were independently predictive of future cardiovascular events. This approach may therefore be of clinical interest with the potential of improving risk stratification after AMI with reduced LVEF while further opening new avenues for biomarker-guided targeted therapies. Copyright © 2017 Elsevier B.V. All rights reserved.

Education as a Public Good: Justification and Avenues of Values Integration into Management of Ugandan School Discipline

ERIC Educational Resources Information Center

Sekiwu, Denis; Botha, M. M.

2014-01-01

This qualitative study employs grounded theory and the Wilsonian concept analysis, as interpretative paradigms, to examine participants' voices on the justification and avenues of values integration into management of school discipline in Uganda. By using John Dewey's educational philosophy [pragmatism] as the theoretical lens for the study, we…

Studying Two-Dimensional Zeolites with the Tools of Surface Science: MFI Nanosheets on Au(111)

DOE PAGES

J. D. Kestell; Zhong, J. Q.; Shete, M.; ...

2016-07-26

While surface science has provided fundamental insights into a variety a materials, the most used catalysts in the industry, namely zeolites, still remain a challenge. The recent preparation of two-dimensional versions of MFI zeolite frameworks and the possibility of their deposition on electrically conductive supports provides for the first time a viable strategy to perform detailed studies on industrially relevant zeolites using the vast toolkit of surface science. In this work we demonstrate the use of infrared reflection absorption spectroscopy (IRRAS) and synchrotron-based x-ray photoelectron spectroscopy (XPS) to study these materials. Furthermore, polarization modulation IRRAS is used to study themore » adsorption of methanol and its effect in phonon vibrations of the zeolite framework. The possibility of using surface science methods, in particular under ambient pressure conditions, for the study of well-defined zeolites and other microporous structures opens new avenues to understand structural and mechanistic aspects of these materials as catalysts, adsorbents and molecular sieves.« less

Studying Two-Dimensional Zeolites with the Tools of Surface Science: MFI Nanosheets on Au(111)

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. D. Kestell; Zhong, J. Q.; Shete, M.

While surface science has provided fundamental insights into a variety a materials, the most used catalysts in the industry, namely zeolites, still remain a challenge. The recent preparation of two-dimensional versions of MFI zeolite frameworks and the possibility of their deposition on electrically conductive supports provides for the first time a viable strategy to perform detailed studies on industrially relevant zeolites using the vast toolkit of surface science. In this work we demonstrate the use of infrared reflection absorption spectroscopy (IRRAS) and synchrotron-based x-ray photoelectron spectroscopy (XPS) to study these materials. Furthermore, polarization modulation IRRAS is used to study themore » adsorption of methanol and its effect in phonon vibrations of the zeolite framework. The possibility of using surface science methods, in particular under ambient pressure conditions, for the study of well-defined zeolites and other microporous structures opens new avenues to understand structural and mechanistic aspects of these materials as catalysts, adsorbents and molecular sieves.« less

7. View looking northwest along Cedar Avenue Bridge. Delaware, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. View looking northwest along Cedar Avenue Bridge. - Delaware, Lackawanna & Western Railroad, Scranton Yards, Cedar Avenue Bridge, Spanning Cedar Avenue at Railroad Alley, Scranton, Lackawanna County, PA

Open reduction and internal fixation of patellar fractures with tension band wiring through cannulated screws.

PubMed

Malik, Mudasir; Halwai, Manzoor Ahmad

2014-10-01

The purpose of this study was to evaluate effectiveness and safety of a relatively new technique of open reduction and internal fixation of displaced transverse patellar fractures with tension band wiring (TBW) through parallel cannulated compression screws. A total of 30 patients with displaced transverse patellar fracture were enrolled in this prospective study. Of the 30 patients, 20 patients had trauma due to fall, 5 due to road traffic accident, 2 due to fall of heavy object on the knee, 2 due to forced flexion of knee, and 1 had fracture due to being beaten. All 30 patients were treated with vertical skin exposure, fracture open reduction, and internal fixation by anterior TBW through 4.0 mm cannulated screws. The postoperative rehabilitation protocol was standardized. The patients were followed postsurgery to evaluate time required for radiographic bone union, knee joint range of motion (ROM), loss of fracture reduction, material failure, and the overall functional result of knee using Bostman scoring. All the fractures healed radiologically, at an average time of 10.7 weeks (range, 8-12 weeks). The average ROM arc was 129.7 degrees (range, 115-140 degrees). No patient had loss of fracture reduction, implant migration, or material failure. The average Bostman score was 28.6 out of 30. Anterior TBW through cannulated screws for displaced transverse fractures is safe and effective alternative treatment. Good functional results and recovery can be expected. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

4. Underside and southeast end of Cedar Avenue Bridge. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Underside and southeast end of Cedar Avenue Bridge. - Delaware, Lackawanna & Western Railroad, Scranton Yards, Cedar Avenue Bridge, Spanning Cedar Avenue at Railroad Alley, Scranton, Lackawanna County, PA

8. Perspective view of Cedar Avenue Bridge looking east. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Perspective view of Cedar Avenue Bridge looking east. - Delaware, Lackawanna & Western Railroad, Scranton Yards, Cedar Avenue Bridge, Spanning Cedar Avenue at Railroad Alley, Scranton, Lackawanna County, PA

Influence of avenue-trees on air quality at the urban neighborhood scale. Part II: traffic pollutant concentrations at pedestrian level.

PubMed

Gromke, Christof; Blocken, Bert

2015-01-01

Flow and dispersion of traffic-emitted pollutants were studied in a generic urban neighborhood for various avenue-tree layouts by employing 3D steady RANS simulations with the realizable k-ε turbulence model. In comparison to the tree-free situation quantitative and qualitative changes with flow reversal in the wind field were observed. Low to moderate increases (<13.2%) in the neighborhood-averaged pollutant concentration were found at pedestrian level. An approximately 1% increase in the neighborhood-averaged concentration was obtained with each percent of the street canyon volumes being occupied by vegetation for occupation fractions between 4 and 14%. The overall pattern of concentration changes relative to the tree-free situation was similar for all avenue-tree layouts. However, pronounced locally restricted decreases or increases in concentration (-87 to +1378%) occurred. The results indicate the necessity to account for existing or planned avenue-trees in neighborhood scaled is dispersion studies. Their consideration is prerequisite for reliable urban air quality assessment.

Journal of Open Source Software (JOSS): design and first-year review

NASA Astrophysics Data System (ADS)

Smith, Arfon M.

2018-01-01

JOSS is a free and open-access journal that publishes articles describing research software across all disciplines. It has the dual goals of improving the quality of the software submitted and providing a mechanism for research software developers to receive credit. While designed to work within the current merit system of science, JOSS addresses the dearth of rewards for key contributions to science made in the form of software. JOSS publishes articles that encapsulate scholarship contained in the software itself, and its rigorous peer review targets the software components: functionality, documentation, tests, continuous integration, and the license. A JOSS article contains an abstract describing the purpose and functionality of the software, references, and a link to the software archive. JOSS published more than 100 articles in its first year, many from the scientific python ecosystem (including a number of articles related to astronomy and astrophysics). JOSS is a sponsored project of the nonprofit organization NumFOCUS and is an affiliate of the Open Source Initiative.In this presentation, I'll describes the motivation, design, and progress of the Journal of Open Source Software (JOSS) and how it compares to other avenues for publishing research software in astronomy.

1. OBLIQUE VIEW LOOKING WEST FROM 21ST STREET VIADUCT (SOUTHSIDE) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. OBLIQUE VIEW LOOKING WEST FROM 21ST STREET VIADUCT (SOUTHSIDE) 2000 BLOCK OF MORRIS AVENUE AND HEAVIEST CORNER ON EARTH DISTRICT AT FIRST AVENUE NORTH AND 20TH STREET (CENTER TOP) - Morris Avenue Warehouse District, 2000-2400 blocks of Morris Avenue & 2100-2500 blocks of First Avenue, North, Birmingham, Jefferson County, AL

Overview taken from Facility 2 looking east down Avenue E ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Overview taken from Facility 2 looking east down Avenue E (Russell Avenue). Facility 1 is on left, Facility 1G and 1C in center. View facing east - U.S. Naval Base, Pearl Harbor, Administration Annex, Near Russell Avenue (previously Avenue E), between of Facility Nos. 1C & 1E , Pearl City, Honolulu County, HI

ENTRY ON SOUTHEAST SIDE (WILLISTON AVENUE ENTRY), VIEW FACING NORTHWEST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ENTRY ON SOUTHEAST SIDE (WILLISTON AVENUE ENTRY), VIEW FACING NORTHWEST. - Schofield Barracks Military Reservation, Quadrangle I Administration Building, Williston Avenue between Wright-Smith & Reilly Avenues, Wahiawa, Honolulu County, HI

3. VIEW OF WILLOW CREEK TRESTLE FROM CORNER BASELINE AVENUE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. VIEW OF WILLOW CREEK TRESTLE FROM CORNER BASELINE AVENUE AND 185TH AVENUE, FACING NORTHEAST - Oregon Electric Railway Westside Corridor, Between Watson & 185th Avenues, Beaverton, Washington County, OR

Contextual view of building 733 along Cedar Avenue; camera facing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Contextual view of building 733 along Cedar Avenue; camera facing southwest. - Mare Island Naval Shipyard, WAVES Officers Quarters, Cedar Avenue, west side between Tisdale Avenue & Eighth Street, Vallejo, Solano County, CA

5. Detail of underside of Cedar Avenue Bridge at northwest ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Detail of underside of Cedar Avenue Bridge at northwest end. - Delaware, Lackawanna & Western Railroad, Scranton Yards, Cedar Avenue Bridge, Spanning Cedar Avenue at Railroad Alley, Scranton, Lackawanna County, PA

Looking southwest from Idaho Avenue showing east side and north ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking southwest from Idaho Avenue showing east side and north end with entrance - University of Idaho, University Classroom Building, Line Street between University Avenue & Idaho Avenue, Moscow, Latah County, ID

Perspective view toward southwest from Idaho Avenue showing east side ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Perspective view toward southwest from Idaho Avenue showing east side and north end - University of Idaho, University Classroom Building, Line Street between University Avenue & Idaho Avenue, Moscow, Latah County, ID

78 FR 47778 - The Boeing Company Boeing Commercial Aircraft (BCA) Auburn, Washington; The Boeing Company Boeing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

... Building 535 Garden Avenue North, Renton, Washington and 10-18 Building 635 Park Avenue North, Renton... include workers at the 10-16 Building 535 Garden Avenue North, Renton, Washington and 10-18 Building 635... Garden Avenue North and 10-18 Building 635 Park Avenue North, Renton, Washington (TA-W-82,705C), The...

Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

Looking southeast from intersection of Idaho Avenue and Line Street ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking southeast from intersection of Idaho Avenue and Line Street showing north end and west front - University of Idaho, University Classroom Building, Line Street between University Avenue & Idaho Avenue, Moscow, Latah County, ID

Conservation and Divergence of Mediator Structure and Function: Insights from Plants.

PubMed

Dolan, Whitney L; Chapple, Clint

2017-01-01

The Mediator complex is a large, multisubunit, transcription co-regulator that is conserved across eukaryotes. Studies of the Arabidopsis Mediator complex and its subunits have shown that it functions in nearly every aspect of plant development and fitness. In addition to revealing mechanisms of regulation of plant-specific pathways, studies of plant Mediator complexes have the potential to shed light on the conservation and divergence of Mediator structure and function across Kingdoms and plant lineages. The majority of insights into plant Mediator function have come from Arabidopsis because it is the only plant from which Mediator has been purified and from which an array of Mediator mutants have been isolated by forward and reverse genetics. So far, these studies indicate that, despite low sequence similarity between many orthologous subunits, the overall structure and function of Mediator is well conserved between Kingdoms. Several studies have also expanded our knowledge of Mediator to other plant species, opening avenues of investigation into the role of Mediator in plant adaptation and fitness.

Facilitation of Drug Transport across the Blood-Brain Barrier with Ultrasound and Microbubbles.

PubMed

Meairs, Stephen

2015-08-31

Medical treatment options for central nervous system (CNS) diseases are limited due to the inability of most therapeutic agents to penetrate the blood-brain barrier (BBB). Although a variety of approaches have been investigated to open the BBB for facilitation of drug delivery, none has achieved clinical applicability. Mounting evidence suggests that ultrasound in combination with microbubbles might be useful for delivery of drugs to the brain through transient opening of the BBB. This technique offers a unique non-invasive avenue to deliver a wide range of drugs to the brain and promises to provide treatments for CNS disorders with the advantage of being able to target specific brain regions without unnecessary drug exposure. If this method could be applied for a range of different drugs, new CNS therapeutic strategies could emerge at an accelerated pace that is not currently possible in the field of drug discovery and development. This article reviews both the merits and potential risks of this new approach. It assesses methods used to verify disruption of the BBB with MRI and examines the results of studies aimed at elucidating the mechanisms of opening the BBB with ultrasound and microbubbles. Possible interactions of this novel delivery method with brain disease, as well as safety aspects of BBB disruption with ultrasound and microbubbles are addressed. Initial translational research for treatment of brain tumors and Alzheimer's disease is presented.

PIQUETTE AVENUE STREETSCAPE WITH STUDEBAKER CORPORATION IN FOREGROUND. 411 PIQUETTE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PIQUETTE AVENUE STREETSCAPE WITH STUDEBAKER CORPORATION IN FOREGROUND. 411 PIQUETTE AVENUE IN CENTER, AND FORD PIQIETTE PLANT ON THE OTHER SIDE. (Duplicate color view of HAER MI-349-1) - 411 Piquette Avenue (Industrial), Detroit, MI

12. VISTA SOUTHWEST ON NEW HAMPSHIRE AVENUE TO WASHINGTON CIRCLE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. VISTA SOUTHWEST ON NEW HAMPSHIRE AVENUE TO WASHINGTON CIRCLE FROM RESERVATION NO. 140 AT THE INTERSECTION OF NEW HAMPSHIRE AVENUE, M, AND 21ST STREETS, NW. - New Hampshire Avenue, Washington, District of Columbia, DC

Quantum-dot based nanothermometry in optical plasmonic recording media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maestro, Laura Martinez; Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122; Zhang, Qiming

2014-11-03

We report on the direct experimental determination of the temperature increment caused by laser irradiation in a optical recording media constituted by a polymeric film in which gold nanorods have been incorporated. The incorporation of CdSe quantum dots in the recording media allowed for single beam thermal reading of the on-focus temperature from a simple analysis of the two-photon excited fluorescence of quantum dots. Experimental results have been compared with numerical simulations revealing an excellent agreement and opening a promising avenue for further understanding and optimization of optical writing processes and media.

Topology-optimized dual-polarization Dirac cones

NASA Astrophysics Data System (ADS)

Lin, Zin; Christakis, Lysander; Li, Yang; Mazur, Eric; Rodriguez, Alejandro W.; Lončar, Marko

2018-02-01

We apply a large-scale computational technique, known as topology optimization, to the inverse design of photonic Dirac cones. In particular, we report on a variety of photonic crystal geometries, realizable in simple isotropic dielectric materials, which exhibit dual-polarization Dirac cones. We present photonic crystals of different symmetry types, such as fourfold and sixfold rotational symmetries, with Dirac cones at different points within the Brillouin zone. The demonstrated and related optimization techniques open avenues to band-structure engineering and manipulating the propagation of light in periodic media, with possible applications to exotic optical phenomena such as effective zero-index media and topological photonics.

Investigation of air transportation technology at Princeton University, 1984

NASA Technical Reports Server (NTRS)

Stengel, Robert F.

1987-01-01

The Air Transportation Technology Program at Princeton University, a program emphasizing graduate and undergraduate student research, proceeded along four avenues during 1984: (1) guidance and control strategies for penetration of microbursts and wind shear; (2) application of artificial intelligence in flight control systems; (3) effects of control saturation on closed loop stability; and (4) response of open loop unstable aircraft. Areas of investigation relate to guidance and control of commercial transports as well as to general aviation aircraft. Interaction between the flight crew and automatic systems is a subject of principle concern. These areas of investigation are briefly discussed.

Investigation of air transportation technology at Princeton University, 1985

NASA Technical Reports Server (NTRS)

Stengel, Robert F.

1987-01-01

The program proceeded along five avenues during 1985. Guidance and control strategies for penetration of microbursts and wind shear, application of artificial intelligence in flight control and air traffic control systems, the use of voice recognition in the cockpit, the effects of control saturation on closed-loop stability and response of open-loop unstable aircraft, and computer aided control system design are among the topics briefly considered. Areas of investigation relate to guidance and control of commercial transports as well as general aviation aircraft. Interaction between the flight crew and automatic systems is the subject of principal concern.

DOE Office of Scientific and Technical Information (OSTI.GOV)

He, Qing Lin; Pan, Lei; Stern, Alexander L.

Majorana fermion is a hypothetical particle that is its own antiparticle. We report transport measurements that suggest the existence of one-dimensional chiral Majorana fermion modes in the hybrid system of a quantum anomalous Hall insulator thin film coupled with a superconductor. As the external magnetic field is swept, half-integer quantized conductance plateaus are observed at the locations of magnetization reversals, giving a distinct signature of the Majorana fermion modes. This transport signature is reproducible over many magnetic field sweeps and appears at different temperatures. This finding may open up an avenue to control Majorana fermions for implementing robust topological quantummore » computing.« less

Removing Gaps in the Exclusion of Top Squark Parameter Space

NASA Astrophysics Data System (ADS)

Czakon, Michal; Mitov, Alexander; Papucci, Michele; Ruderman, Joshua T.; Weiler, Andreas

2014-11-01

Light stops are a hallmark of the most natural realizations of weak-scale supersymmetry. While stops have been extensively searched for, there remain open gaps around and below the top mass, due to similarities of stop and top signals with current statistics. We propose a new fast-track avenue to improve light stop searches for R -parity-conserving supersymmetry by comparing top cross section measurements to the theoretical prediction. Stop masses below ˜180 GeV can now be ruled out for a light neutralino. The possibility of a stop signal contaminating the top mass measurement is also briefly addressed.

Recent Progress Towards Quantum Dot Solar Cells with Enhanced Optical Absorption.

PubMed

Zheng, Zerui; Ji, Haining; Yu, Peng; Wang, Zhiming

2016-12-01

Quantum dot solar cells, as a promising candidate for the next generation solar cell technology, have received tremendous attention in the last 10 years. Some recent developments in epitaxy growth and device structures have opened up new avenues for practical quantum dot solar cells. Unfortunately, the performance of quantum dot solar cells is often plagued by marginal photon absorption. In this review, we focus on the recent progress made in enhancing optical absorption in quantum dot solar cells, including optimization of quantum dot growth, improving the solar cells structure, and engineering light trapping techniques.

A dynamic model of stress and sustained attention

NASA Technical Reports Server (NTRS)

Hancock, P. A.; Warm, Joel S.

1989-01-01

Arguments are presented that an integrated view of stress and performance must consider the task demanding a sustained attention as a primary source of cognitive stress. A dynamic model is developed on the basis of the concept of adaptability in both physiological and psychological terms, that addresses the effects of stress on vigilance and, potentially, a wide variety of attention-demanding performance tasks. The model provides an insight into the failure of an operator under the driving influences of stress and opens a number of potential avenues through which solutions to the complex challenge of stress and performance might be posed.

Wigner's "Polanyian" Epistemology and the Measurement Problem: The Wigner-Polanyi Dialog on Tacit Knowledge

NASA Astrophysics Data System (ADS)

Jha, Stefania

2011-09-01

I analyze the long dialog that Eugene Wigner (1902-1995) and Michael Polanyi (1891-1976) carried out on Polanyi's concept of tacit knowledge and its meaning for the measurement problem in quantum physics, focusing in particular on their ten-year correspondence between 1961 and 1971 on these subjects and the related mind-body problem. They differed in their interpretations, epistemologies, and ontologies, and consequently never resolved their differences on the measurement and mind-body problems. Nonetheless, their long dialog is significant and opens up avenues for exploring these problems further.

Cognitive, social, and neural determinants of diminished decision-making and financial exploitation risk in aging and dementia: A review and new model.

PubMed

Spreng, R Nathan; Karlawish, Jason; Marson, Daniel C

2016-01-01

In this article we will briefly review how changes in brain and in cognitive and social functioning, across the spectrum from normal to pathological aging, can lead to decision-making impairments that increase abuse risk in many life domains (e.g., health care, social engagement, financial management). The review will specifically focus on emerging research identifying neural, cognitive, and social markers of declining financial decision-making capacity in older adults. We will highlight how these findings are opening avenues for early detection and new interventions to reduce exploitation risk.

Can the "musical stroop" task replace the classical stroop task? Commentary on “The musical Stroop effect: Opening a new avenue to research on automatisms” by l. Grégoire, P. Perruchet, and B. Poulin-Charronnat (Experimental Psychology, 2013, vol. 60, pp. 269–278).

PubMed

Zakay, Dan

2014-01-01

The musical Stroop task is analyzed and compared to the classical Stroop task. The analysis indicates that the two tasks differ in the following significant characteristics: ecological validity, the interrelations between the two perceptual dimensions involved, the nature of the automatic process and the existence of a potential Garner interference. It is concluded that the musical task has no advantage over the classical task.

Dimensionality-Driven Metal-Insulator Transition in Spin-Orbit-Coupled SrIrO3

NASA Astrophysics Data System (ADS)

Schütz, P.; Di Sante, D.; Dudy, L.; Gabel, J.; Stübinger, M.; Kamp, M.; Huang, Y.; Capone, M.; Husanu, M.-A.; Strocov, V. N.; Sangiovanni, G.; Sing, M.; Claessen, R.

2017-12-01

Upon reduction of the film thickness we observe a metal-insulator transition in epitaxially stabilized, spin-orbit-coupled SrIrO3 ultrathin films. By comparison of the experimental electronic dispersions with density functional theory at various levels of complexity we identify the leading microscopic mechanisms, i.e., a dimensionality-induced readjustment of octahedral rotations, magnetism, and electronic correlations. The astonishing resemblance of the band structure in the two-dimensional limit to that of bulk Sr2 IrO4 opens new avenues to unconventional superconductivity by "clean" electron doping through electric field gating.

From evolutionary computation to the evolution of things.

PubMed

Eiben, Agoston E; Smith, Jim

2015-05-28

Evolution has provided a source of inspiration for algorithm designers since the birth of computers. The resulting field, evolutionary computation, has been successful in solving engineering tasks ranging in outlook from the molecular to the astronomical. Today, the field is entering a new phase as evolutionary algorithms that take place in hardware are developed, opening up new avenues towards autonomous machines that can adapt to their environment. We discuss how evolutionary computation compares with natural evolution and what its benefits are relative to other computing approaches, and we introduce the emerging area of artificial evolution in physical systems.

Toward a new STATe: The role of STATs in mitochondrial function

PubMed Central

Meier, Jeremy A.; Larner, Andrew C.

2014-01-01

Signal Transducers and Activators of Transcription (STATs) have been studied extensively and have been associated with virtually every biochemical pathway. Until recently, however, they were thought to exert these effects solely as a nuclear transcription factor. The finding that STAT3 localizes to the mitochondria and modulates respiration has opened up a new avenue through which STATs may regulate the cell. Recently, other members of the STAT family (STAT1, STAT2, STAT5, and STAT6) have also been shown to be present in the mitochondria. Coordinate regulation at the nucleus and mitochondria by these proteins places them in a unique position to drive cellular processes to achieve a specific response. This review summarizes recent findings that have led to our current understanding of how STATs influence mitochondrial function in health and disease. PMID:24434063

Qubit-Programmable Operations on Quantum Light Fields

PubMed Central

Barbieri, Marco; Spagnolo, Nicolò; Ferreyrol, Franck; Blandino, Rémi; Smith, Brian J.; Tualle-Brouri, Rosa

2015-01-01

Engineering quantum operations is a crucial capability needed for developing quantum technologies and designing new fundamental physics tests. Here we propose a scheme for realising a controlled operation acting on a travelling continuous-variable quantum field, whose functioning is determined by a discrete input qubit. This opens a new avenue for exploiting advantages of both information encoding approaches. Furthermore, this approach allows for the program itself to be in a superposition of operations, and as a result it can be used within a quantum processor, where coherences must be maintained. Our study can find interest not only in general quantum state engineering and information protocols, but also details an interface between different physical platforms. Potential applications can be found in linking optical qubits to optical systems for which coupling is best described in terms of their continuous variables, such as optomechanical devices. PMID:26468614

Filling Terrorism Gaps: VEOs, Evaluating Databases, and Applying Risk Terrain Modeling to Terrorism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hagan, Ross F.

2016-08-29

This paper aims to address three issues: the lack of literature differentiating terrorism and violent extremist organizations (VEOs), terrorism incident databases, and the applicability of Risk Terrain Modeling (RTM) to terrorism. Current open source literature and publicly available government sources do not differentiate between terrorism and VEOs; furthermore, they fail to define them. Addressing the lack of a comprehensive comparison of existing terrorism data sources, a matrix comparing a dozen terrorism databases is constructed, providing insight toward the array of data available. RTM, a method for spatial risk analysis at a micro level, has some applicability to terrorism research, particularlymore » for studies looking at risk indicators of terrorism. Leveraging attack data from multiple databases, combined with RTM, offers one avenue for closing existing research gaps in terrorism literature.« less

Role of microstructures on the M1-M2 phase transition in epitaxial VO2 thin films

PubMed Central

Ji, Yanda; Zhang, Yin; Gao, Min; Yuan, Zhen; Xia, Yudong; Jin, Changqing; Tao, Bowan; Chen, Chonglin; Jia, Quanxi; Lin, Yuan

2014-01-01

Vanadium dioxide (VO2) with its unique sharp resistivity change at the metal-insulator transition (MIT) has been extensively considered for the near-future terahertz/infrared devices and energy harvesting systems. Controlling the epitaxial quality and microstructures of vanadium dioxide thin films and understanding the metal-insulator transition behaviors are therefore critical to novel device development. The metal-insulator transition behaviors of the epitaxial vanadium dioxide thin films deposited on Al2O3 (0001) substrates were systematically studied by characterizing the temperature dependency of both Raman spectrum and Fourier transform infrared spectroscopy. Our findings on the correlation between the nucleation dynamics of intermediate monoclinic (M2) phase with microstructures will open a new avenue for the design and integration of advanced heterostructures with controllable multifunctionalities for sensing and imaging system applications. PMID:24798056

Novel Botulinum Neurotoxins: Exploring Underneath the Iceberg Tip.

PubMed

Tehran, Domenico Azarnia; Pirazzini, Marco

2018-05-10

Botulinum neurotoxins (BoNTs), the etiological agents of botulism, are the deadliest toxins known to humans. Yet, thanks to their biological and toxicological features, BoNTs have become sophisticated tools to study neuronal physiology and valuable therapeutics for an increasing number of human disorders. BoNTs are produced by multiple bacteria of the genus Clostridium and, on the basis of their different immunological properties, were classified as seven distinct types of toxin. BoNT classification remained stagnant for the last 50 years until, via bioinformatics and high-throughput sequencing techniques, dozens of BoNT variants, novel serotypes as well as BoNT-like toxins within non-clostridial species have been discovered. Here, we discuss how the now “booming field” of botulinum neurotoxin may shed light on their evolutionary origin and open exciting avenues for future therapeutic applications.

Single-particle cryo-electron microscopy of Rift Valley fever virus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sherman, Michael B.; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555; Freiberg, Alexander N.

2009-04-25

Rift Valley fever virus (RVFV; Bunyaviridae; Phlebovirus) is an emerging human and veterinary pathogen causing acute hepatitis in ruminants and has the potential to cause hemorrhagic fever in humans. We report a three-dimensional reconstruction of RVFV vaccine strain MP-12 (RVFV MP-12) by cryo-electron microcopy using icosahedral symmetry of individual virions. Although the genomic core of RVFV MP-12 is apparently poorly ordered, the glycoproteins on the virus surface are highly symmetric and arranged on a T = 12 icosahedral lattice. Our RVFV MP-12 structure allowed clear identification of inter-capsomer contacts and definition of possible glycoprotein arrangements within capsomers. This structure providesmore » a detailed model for phleboviruses, opens new avenues for high-resolution structural studies of the bunyavirus family, and aids the design of antiviral diagnostics and effective subunit vaccines.« less

Salmonella modulation of host cell gene expression promotes its intracellular growth.

PubMed

Hannemann, Sebastian; Gao, Beile; Galán, Jorge E

2013-01-01

Salmonella Typhimurium has evolved a complex functional interface with its host cell largely determined by two type III secretion systems (T3SS), which through the delivery of bacterial effector proteins modulate a variety of cellular processes. We show here that Salmonella Typhimurium infection of epithelial cells results in a profound transcriptional reprogramming that changes over time. This response is triggered by Salmonella T3SS effector proteins, which stimulate unique signal transduction pathways leading to STAT3 activation. We found that the Salmonella-stimulated changes in host cell gene expression are required for the formation of its specialized vesicular compartment that is permissive for its intracellular replication. This study uncovers a cell-autonomous process required for Salmonella pathogenesis potentially opening up new avenues for the development of anti-infective strategies that target relevant host pathways.

Exploring the Spatiotemporal Organization of Membrane Proteins in Living Plant Cells.

PubMed

Wang, Li; Xue, Yiqun; Xing, Jingjing; Song, Kai; Lin, Jinxing

2018-04-29

Plasma membrane proteins have important roles in transport and signal transduction. Deciphering the spatiotemporal organization of these proteins provides crucial information for elucidating the links between the behaviors of different molecules. However, monitoring membrane proteins without disrupting their membrane environment remains difficult. Over the past decade, many studies have developed single-molecule techniques, opening avenues for probing the stoichiometry and interactions of membrane proteins in their native environment by providing nanometer-scale spatial information and nanosecond-scale temporal information. In this review, we assess recent progress in the development of labeling and imaging technology for membrane protein analysis. We focus in particular on several single-molecule techniques for quantifying the dynamics and assembly of membrane proteins. Finally, we provide examples of how these new techniques are advancing our understanding of the complex biological functions of membrane proteins.

Bistable four-wave mixing response in a semiconductor quantum dot coupled to a photonic crystal nanocavity.

PubMed

Li, Jian-Bo; Xiao, Si; Liang, Shan; He, Meng-Dong; Luo, Jian-Hua; Kim, Nam-Chol; Chen, Li-Qun

2017-10-16

We perform a theoretical study of the bistable four-wave mixing (FWM) response in a coupled system comprised of a semiconductor quantum dot (SQD) and a photonic crystal (PC) nanocavity in which the SQD is embedded. It is shown that the shape of the FWM spectrum can switch among single-peaked, double-peaked, triple-peaked, and four-peaked arising from the vacuum Rabi splitting and the exciton-nanocavity coupling. Especially, we map out bistability phase diagrams within a parameter subspace of the system, and find that it is easy to turn on or off the bistable FWM response by only adjusting the excitation frequency or the pumping intensity. Our results offer a feasible means for measuring the SQD-PC nanocavity coupling strength and open a new avenue to design optical switches and memories.

Personality predicts the vibrancy of colour imagery: The case of synaesthesia.

PubMed

Hossain, Shyla R; Simner, Julia; Ipser, Alberta

2017-07-01

In this study we show that personality traits predict the physical qualities of mentally generated colours, using the case of synaesthesia. Developmental grapheme-colour synaesthetes have the automatic lifelong association of colours paired to letters or digits. Although these colours are internal mental constructs, they can be measured along physical dimensions such as saturation and luminance. The personality of synaesthetes can also be quantified using self-report questionnaires relating, for example, to the five major traits of Conscientiousness, Extraversion, Agreeableness, Neuroticism, and Openness to Experience. In this paper, we bring together both types of quality by examining whether the personality of individual synaesthetes predicts their synaesthetic colours. Twenty grapheme-colour synaesthetes were tested with the Big Five Inventory (BFI) personality questionnaire. Their synaesthesia was also tested in terms of consistency and average colour saturation and luminance. Two major results were found: although personality did not influence the overall robustness (i.e., consistency) of synaesthesia, it predicted the nature of synaesthetes' colours: the trait of Openness was positively correlated with the saturation of synaesthetic colours. Our study provides evidence that personality and internal perception are intertwined, and suggests future avenues of research for investigating the associations between the two. Copyright © 2017 Elsevier Ltd. All rights reserved.

Comparison between Closing-Wedge and Opening-Wedge High Tibial Osteotomy in Patients with Medial Knee Osteoarthritis: A Systematic Review and Meta-analysis.

PubMed

Sun, Hao; Zhou, Lin; Li, Fengsheng; Duan, Jun

2017-02-01

Young active patients with medial knee osteoarthritis (OA) combined with varus leg alignment can be treated with high tibial osteotomy (HTO) to stop the progression of OA and avoid or postpone total knee arthroplasty (TKA). Closing-wedge osteotomy (CWO) and opening-wedge osteotomy (OWO) are the most commonly used osteotomy techniques. The purpose of this study was to compare the clinical and radiologic outcomes and complications between OWO and CWO. We retrospectively evaluated 23 studies including 17 clinical trials from published databases from their inception to May 2015. We evaluated the clinical outcomes including operation time, visual analog scale (VAS), maximal flexion, and hospital for special surgery knee (HSS) score. The radiologic outcomes included patellar height measured by posterior tibial slope angle, hip-knee-ankle (HKA) angle, femorotibial (FT) axis, and limb length. Complications recorded included the incidence of deep vein thrombosis (DVT), common peroneal nerve injury, opposite cortical fracture, etc. There were no differences in most of the clinical outcomes except the operation time. OWO increased the posterior slope angle and limb length, decreased the patellar height, and provided higher accuracy of correction. CWO led to a higher incidence of opposite cortical fracture. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Effects of channel blocking on information transmission and energy efficiency in squid giant axons.

PubMed

Liu, Yujiang; Yue, Yuan; Yu, Yuguo; Liu, Liwei; Yu, Lianchun

2018-04-01

Action potentials are the information carriers of neural systems. The generation of action potentials involves the cooperative opening and closing of sodium and potassium channels. This process is metabolically expensive because the ions flowing through open channels need to be restored to maintain concentration gradients of these ions. Toxins like tetraethylammonium can block working ion channels, thus affecting the function and energy cost of neurons. In this paper, by computer simulation of the Hodgkin-Huxley neuron model, we studied the effects of channel blocking with toxins on the information transmission and energy efficiency in squid giant axons. We found that gradually blocking sodium channels will sequentially maximize the information transmission and energy efficiency of the axons, whereas moderate blocking of potassium channels will have little impact on the information transmission and will decrease the energy efficiency. Heavy blocking of potassium channels will cause self-sustained oscillation of membrane potentials. Simultaneously blocking sodium and potassium channels with the same ratio increases both information transmission and energy efficiency. Our results are in line with previous studies suggesting that information processing capacity and energy efficiency can be maximized by regulating the number of active ion channels, and this indicates a viable avenue for future experimentation.

36 CFR 908.30 - Request for review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 908.30 Parks, Forests, and Public Property PENNSYLVANIA AVENUE DEVELOPMENT CORPORATION POLICY AND PROCEDURES TO FACILITATE THE RETENTION OF DISPLACED BUSINESSES AND RESIDENTS IN THE PENNSYLVANIA AVENUE... Director of Real Estate, Pennsylvania Avenue Development Corporation, 1331 Pennsylvania Avenue, NW., Suite...

33. 193195 AUBURN AVENUE (Callaway BuildingGeorgia Insurance Brokerage Inc.) (Consolidated ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. 193-195 AUBURN AVENUE (Callaway Building--Georgia Insurance Brokerage Inc.) (Consolidated Mortgage Building--Three Sisters Beauty Shop; Alston & Co. Realty and Property Management) NORTH ELEVATION - 126-255 Auburn Avenue (Commercial Buildings), Auburn Avenue, Atlanta, Fulton County, GA

FACILITY 858, PORTION OF NORTHEAST SIDE (APRON AVENUE SIDE), SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACILITY 858, PORTION OF NORTHEAST SIDE (APRON AVENUE SIDE), SHOWING CHEVRON DESIGN OVER FORMER PASSAGEWAY, OBLIQUE VIEW FACING WEST. - Schofield Barracks Military Reservation, Quadrangle K Barracks Type, Between Wilson Street & Capron Avenue near Williston Avenue, Wahiawa, Honolulu County, HI

76 FR 50446 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-15

... intersection of Inspiration Avenue and D Avenue, and comments pertaining to the Sal Taylor Creek Tributary 2... modified BFE is approximately 0.51 mile upstream of the intersection of Inspiration Avenue and D Avenue... mile upstream of the intersection of [[Page 50447

Highly Active N,O Zinc Guanidine Catalysts for the Ring-Opening Polymerization of Lactide.

PubMed

Schäfer, Pascal M; Fuchs, Martin; Ohligschläger, Andreas; Rittinghaus, Ruth; McKeown, Paul; Akin, Enver; Schmidt, Maximilian; Hoffmann, Alexander; Liauw, Marcel A; Jones, Matthew D; Herres-Pawlis, Sonja

2017-09-22

New zinc guanidine complexes with N,O donor functionalities were prepared, characterized by X-Ray crystallography, and examined for their catalytic activity in the solvent-free ring-opening polymerization (ROP) of technical-grade rac-lactide at 150 °C. All complexes showed a high activity. The fastest complex [ZnCl 2 (DMEGasme)] (C1) produced colorless poly(lactide) (PLA) after 90 min with a conversion of 52 % and high molar masses (M w =69 100, polydispersity=1.4). The complexes were tested with different monomer-to-initiator ratios to determine the rate constant k p . Furthermore, a polymerization with the most active complex C1 was monitored by in situ Raman spectroscopy. Overall, conversion of up to 90 % can be obtained. End-group analysis was performed to clarify the mechanism. All four complexes combine robustness against impurities in the lactide with high polymerization rates, and they represent the fastest robust lactide ROP catalysts to date, opening new avenues to a sustainable ROP catalyst family for industrial use. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

A microscopic solution to the magnetic detwinning mystery in EuFe2As2

NASA Astrophysics Data System (ADS)

Maiwald, J.; Mazin, I. I.; Nandi, S.; Xiao, Y.; Gegenwart, P.

One of the greatest recent advances in studying nematic phenomena in Fe-based superconductors was the mechanical detwinning of the 122-family compounds. Unfortunately, these techniques generate considerable stress in the investigated samples, which contaminates the results. Recently, we observed that a minuscule magnetic field of the order of 0.1 T irreversibly and persistently detwins EuFe2As2, opening an entirely new avenue for addressing nematicity. However, further development was hindered by the absence of a microscopic theory explaining this magnetic detwinning. In fact, Eu2+ has zero orbital moment and does not couple to the lattice, and its exchange coupling with the Fe sublattice cancels by symmetry. Moreover, further increase of the field to 1 T leads to a reorientation of Fe domains, while even larger fields 10 T reorient the domains once again. We will present a new microscopic model, based on a sizable biquadratic coupling between the Fe 3 d and Eu 4 f moments. This model quantitatively explains our old and new magnetization and neutron diffraction data, thus removing the veil of mystery and finally opening the door to full-scale research into magnetic detwinning and nematicity in Fe-based superconductors.

International Barcode of Life: Focus on big biodiversity in South Africa.

PubMed

Adamowicz, Sarah J; Hollingsworth, Peter M; Ratnasingham, Sujeevan; van der Bank, Michelle

2017-11-01

Participants in the 7th International Barcode of Life Conference (Kruger National Park, South Africa, 20-24 November 2017) share the latest findings in DNA barcoding research and its increasingly diversified applications. Here, we review prevailing trends synthesized from among 429 invited and contributed abstracts, which are collated in this open-access special issue of Genome. Hosted for the first time on the African continent, the 7th Conference places special emphasis on the evolutionary origins, biogeography, and conservation of African flora and fauna. Within Africa and elsewhere, DNA barcoding and related techniques are being increasingly used for wildlife forensics and for the validation of commercial products, such as medicinal plants and seafood species. A striking trend of the conference is the dramatic rise of studies on environmental DNA (eDNA) and on diverse uses of high-throughput sequencing techniques. Emerging techniques in these areas are opening new avenues for environmental biomonitoring, managing species-at-risk and invasive species, and revealing species interaction networks in unprecedented detail. Contributors call for the development of validated community standards for high-throughput sequence data generation and analysis, to enable the full potential of these methods to be realized for understanding and managing biodiversity on a global scale.

Proteomics technique opens new frontiers in mobilome research.

PubMed

Davidson, Andrew D; Matthews, David A; Maringer, Kevin

2017-01-01

A large proportion of the genome of most eukaryotic organisms consists of highly repetitive mobile genetic elements. The sum of these elements is called the "mobilome," which in eukaryotes is made up mostly of transposons. Transposable elements contribute to disease, evolution, and normal physiology by mediating genetic rearrangement, and through the "domestication" of transposon proteins for cellular functions. Although 'omics studies of mobilome genomes and transcriptomes are common, technical challenges have hampered high-throughput global proteomics analyses of transposons. In a recent paper, we overcame these technical hurdles using a technique called "proteomics informed by transcriptomics" (PIT), and thus published the first unbiased global mobilome-derived proteome for any organism (using cell lines derived from the mosquito Aedes aegypti ). In this commentary, we describe our methods in more detail, and summarise our major findings. We also use new genome sequencing data to show that, in many cases, the specific genomic element expressing a given protein can be identified using PIT. This proteomic technique therefore represents an important technological advance that will open new avenues of research into the role that proteins derived from transposons and other repetitive and sequence diverse genetic elements, such as endogenous retroviruses, play in health and disease.

Chiral quantum dot based materials

NASA Astrophysics Data System (ADS)

Govan, Joseph; Loudon, Alexander; Baranov, Alexander V.; Fedorov, Anatoly V.; Gun'ko, Yurii

2014-05-01

Recently, the use of stereospecific chiral stabilising molecules has also opened another avenue of interest in the area of quantum dot (QD) research. The main goal of our research is to develop new types of technologically important quantum dot materials containing chiral defects, study their properties and explore their applications. The utilisation of chiral penicillamine stabilisers allowed the preparation of new water soluble white emitting CdS quantum nanostructures which demonstrated circular dichroism in the band-edge region of the spectrum. It was also demonstrated that all three types of QDs (D-, L-, and Rac penicillamine stabilised) show very broad emission bands between 400 and 700 nm due to defects or trap states on the surfaces of the nanocrystals. In this work the chiral CdS based quantum nanostructures have also been doped by copper metal ions and new chiral penicilamine stabilized CuS nanoparticles have been prepared and investigated. It was found that copper doping had a strong effect at low levels in the synthesis of chiral CdS nanostructures. We expect that this research will open new horizons in the chemistry of chiral nanomaterials and their application in biotechnology, sensing and asymmetric synthesis.

gDNA enrichment by a transposase-based technology for NGS analysis of the whole sequence of BRCA1, BRCA2, and 9 genes involved in DNA damage repair.

PubMed

Chevrier, Sandy; Boidot, Romain

2014-10-06

The widespread use of Next Generation Sequencing has opened up new avenues for cancer research and diagnosis. NGS will bring huge amounts of new data on cancer, and especially cancer genetics. Current knowledge and future discoveries will make it necessary to study a huge number of genes that could be involved in a genetic predisposition to cancer. In this regard, we developed a Nextera design to study 11 complete genes involved in DNA damage repair. This protocol was developed to safely study 11 genes (ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, PALB2, RAD50, RAD51C, RAD80, and TP53) from promoter to 3'-UTR in 24 patients simultaneously. This protocol, based on transposase technology and gDNA enrichment, gives a great advantage in terms of time for the genetic diagnosis thanks to sample multiplexing. This protocol can be safely used with blood gDNA.

Understanding illegality and corruption in forest governance.

PubMed

Sundström, Aksel

2016-10-01

This review synthesizes the literature studying illegality and government corruption in forest management. After discussing the theoretical connections between different types of corruption and illegal forest-related activities it describes the major trends in previous studies, examining cross-national patterns as well as local in-depth studies. Both theory and available empirical findings provide a straightforward suggestion: Bribery is indeed a "door opener" for illegal activities to take place in forest management. It then discusses the implications for conservation, focusing first on international protection schemes such as the REDD+ and second on efforts to reduce illegality and bribery in forest management. Key aspects to consider in the discussion on how to design monitoring institutions of forest regulations is how to involve actors without the incentive to engage in bribery and how to make use of new technologies that may publicize illegal behavior in distant localities. The review concludes by discussing avenues for future research. Copyright © 2016 Elsevier Ltd. All rights reserved.

Detergent/Nanodisc Screening for High-Resolution NMR Studies of an Integral Membrane Protein Containing a Cytoplasmic Domain

PubMed Central

Maslennikov, Innokentiy; Choe, Senyon; Riek, Roland

2013-01-01

Because membrane proteins need to be extracted from their natural environment and reconstituted in artificial milieus for the 3D structure determination by X-ray crystallography or NMR, the search for membrane mimetic that conserve the native structure and functional activities remains challenging. We demonstrate here a detergent/nanodisc screening study by NMR of the bacterial α-helical membrane protein YgaP containing a cytoplasmic rhodanese domain. The analysis of 2D [15N,1H]-TROSY spectra shows that only a careful usage of low amounts of mixed detergents did not perturb the cytoplasmic domain while solubilizing in parallel the transmembrane segments with good spectral quality. In contrast, the incorporation of YgaP into nanodiscs appeared to be straightforward and yielded a surprisingly high quality [15N,1H]-TROSY spectrum opening an avenue for the structural studies of a helical membrane protein in a bilayer system by solution state NMR. PMID:23349867