Biomass Structure and Its Contributions to Recalcitrance During Consolidated Bioprocessing with Clostridium Thermocellum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akinosho, Hannah O.

Each study provided compelling reasoning to strongly consider lignin’s part in limiting CBP efficiencies at the laboratory and eventually the industrial scale. To make cellulosic ethanol production feasible with CBP, lignin structure and content must be manipulated with genetic modifications or carefully selected in natural variants to combat these difficulties.

Professional Learning Communities by Design: Putting the Learning Back into PLCs

ERIC Educational Resources Information Center

Easton, Lois Brown

2011-01-01

If you are looking for an organic approach to purpose-driven professional learning, this is the book for you. Award-winning educator Lois Brown Easton's latest work provides a compelling case study in narrative form, a chronological PLC planning outline, and first-hand "lessons learned" about how PLCs develop, mature, and sustain themselves. You…

Accuracy of a Rationally Derived Method for Identifying Treatment Failure in Children and Adolescents

ERIC Educational Resources Information Center

Bishop, Matthew J.; Bybee, Taige S.; Lambert, Michael J.; Burlingame, Gary M.; Wells, M. Gawain; Poppleton, Landon E.

2005-01-01

Psychotherapy outcome can be enhanced by early identification of potential treatment failures before they leave treatment. In adults, compelling data are emerging that provide evidence that an early warning system that identifies potential treatment failures can be developed and applied to enhance outcome. The present study reports an analysis of…

Adolescents’ impressions of antismoking media literacy education: qualitative results from a randomized controlled trial

PubMed Central

Primack, Brian A.; Fine, Danielle; Yang, Christopher K.; Wickett, Dustin; Zickmund, Susan

2009-01-01

Although media literacy represents an innovative venue for school-based antismoking programming, studies have not systematically compared student impressions of these and traditional programs. This study utilized data from a randomized trial comparing these two types of programs. After each program, students responded to three open-ended questions related to their assigned curriculum. Two coders, blinded to student assignments, independently coded these data. Coders had strong inter-rater agreement (kappa = 0.77). Our primary measures were spontaneously noted overall assessment, enjoyment/interest and the likelihood of changing smoking behavior. Of the 531 participants, 255 (48.0%) were randomized to the intervention (media literacy) group. Intervention participants had more net positive responses [rate ratio (RR) = 1.27, 95% confidence interval (CI) = 1.05, 1.54], more responses rating the program as compelling (RR = 1.63, 95% CI = 1.16, 2.29) and fewer responses rating the program as non-compelling (RR = 0.62, 95% CI = 0.39, 0.97). However, the intervention group was not more likely to suggest that the curriculum was likely to change behavior positively (RR = 0.57, 95% CI = 0.30, 1.06). Findings suggest that although media literacy provides a compelling format for the delivery of antitobacco programming, integration of components of traditional programming may help media literacy programs achieve maximal efficacy. PMID:19052155

The Association between Pediatric NAFLD and Common Genetic Variants

PubMed Central

Umano, Giuseppina Rosaria; Martino, Mariangela; Santoro, Nicola

2017-01-01

Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of obesity. Several studies have shown that genetic predisposition probably plays an important role in its pathogenesis. In fact, in the last few years a large number of genetic studies have provided compelling evidence that some gene variants, especially those in genes encoding proteins regulating lipid metabolism, are associated with intra-hepatic fat accumulation. Here we provide a comprehensive review of the gene variants that have affected the natural history of the disease. PMID:28629152

Compelling Counternarratives to Deficit Discourses: An Investigation into the Funds of Knowledge of Culturally and Linguistically Diverse U.S. Elementary Students' Households

ERIC Educational Resources Information Center

Kinney, Angela

2015-01-01

This study focused on household funds of knowledge or "historically accumulated bodies of knowledge and skills essential for household functioning and well-being" (Gonzalez, Andrade, Civil, & Moll, 2001). A Funds of Knowledge approach provides both a methodological and theoretical lens for educators to understand both themselves and…

18 CFR 375.309 - Delegations to the General Counsel.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., compel their attendance and testimony, take evidence, compel the filing of special reports and... and affirmations, subpoena witnesses, compel their attendance and testimony, take evidence, compel the... Policy Act of 1978, 15 U.S.C. 3301-3432 (1982). (f) Deny or grant, in whole or in part, petitions for...

Toward Effective and Compelling Instruction for High School eCommerce Students: Results from a Small Field Study

ERIC Educational Resources Information Center

Luterbach, Kenneth J.; Rodriguez, Diane; Love, Lakecia

2012-01-01

This paper describes an instructional development effort to create effective and compelling instruction for eCommerce students. Results from a small field study inform the development project. Four high school students in an eCommerce course completed the standalone tutorial developed to teach them how to create a web page in the HyperText Markup…

Digital Image Manipulation: A Compelling Means to Engage Students in Discussion of Point of View and Perspective

ERIC Educational Resources Information Center

Hofer, Mark; Swan, Kathleen Owings

2005-01-01

With the importance of imagery in our culture and the increasing access to both digital images and the tools used to manipulate them, it is important that social studies teacher educators prepare preservice teachers to provide their students with opportunities to develop a critical lens through which to view images. As we strive to encourage the…

24 CFR 180.540 - Motion to compel discovery.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Motion to compel discovery. 180.540....540 Motion to compel discovery. (a) If a deponent fails to answer a question propounded, or a party... order compelling discovery in accordance with the request. The motion shall: (1) State the nature of the...

Preclinical Mouse Models of Neurofibromatosis

DTIC Science & Technology

2005-11-01

and NF2-deficient human cells and in cells from Nf1 and Nf2 mutant mice. Genetic analysis of human and murine tumors has provided compelling...lethal myeloproliferative disorder (MPD) characterized by over-production of infiltrative myeloid cells (13). JMML has been modeled in mice by...tumor development for 18 months after exposure. Pathologic analysis was performed on 91% of the Shannon, K.M. 11 study cohort, including 95 of 104

Event-Related Potentials (ERPs) in Second Language Research: A Brief Introduction to the Technique, a Selected Review, and an Invitation to Reconsider Critical Periods in L2

ERIC Educational Resources Information Center

Steinhauer, Karsten

2014-01-01

This article provides a selective overview of recent event-related brain potential (ERP) studies in L2 morpho-syntax, demonstrating that the ERP evidence supporting the critical period hypothesis (CPH) may be less compelling than previously thought. The article starts with a general introduction to ERP methodology and language-related ERP profiles…

Naval Ship Procurement Process Study

DTIC Science & Technology

1978-07-01

was to drdw from the troublesome experiences of the past, compelling lessons which the Navy and the shipbuilding industry would be strongly motivated...These interviews provided a number of insights into the process of planning for the acquisition of Navy ships as well as the legal and business...strategies on recent pro- grams. Prospective shipbuilders have participated in the preparation of the con- tract design package, and it is planned on

Professional Development through Organizational Assessment: Using APPA's Facilities Management Evaluation Program

ERIC Educational Resources Information Center

Medlin, E. Lander; Judd, R. Holly

2013-01-01

APPA's Facilities Management Evaluation Program (FMEP) provides an integrated system to optimize organizational performance. The criteria for evaluation not only provide a tool for organizational continuous improvement, they serve as a compelling leadership development tool essential for today's facilities management professional. The senior…

The Cascadia Paradox: Understanding Mantle Flow in the Cascadia Subduction System

NASA Astrophysics Data System (ADS)

Long, M. D.

2015-12-01

The pattern of mantle flow in subduction systems, and the processes that control the mantle flow field, is a fundamental but still poorly understood aspect of subduction dynamics. Mantle flow plays a key role in controlling the transport of volatiles and melt in the wedge, deformation of the overriding plate, mass transfer between the upper and lower mantle, and the morphology and dynamics of slabs. The Cascadia subduction zone provides a compelling system in which to understand the controls on mantle flow, particularly given the dense geophysical observations provided by EarthScope, GeoPRISMS, the Cascadia Initiative, and related efforts. Cascadia is a particularly intriguing system because observations of seismic anisotropy, which provide relatively direct constraints on mantle flow, seem to yield contradictory views of the mantle flow field in different parts of the system. Observations of seismic anisotropy on the overriding plate apparently require a significant component of three-dimensional, toroidal flow around the slab edge, while new observations from offshore stations are compellingly explained with a simple two-dimensional entrained flow model. Recent evidence from seismic tomography for the fragmentation of the Cascadia slab at depth provides a further puzzle: how can a fragmented slab provide a driving force for either two-dimensional entrained flow or three-dimensional toroidal flow due to slab rollback? I will present a synthesis of recent observations of seismic anisotropy in the Cascadia subduction system, and how they can be integrated with constraints from geodynamical modeling, geochemistry, and the history and timing of Pacific Northwest volcanism. I will discuss the compelling but contradictory evidence for each of the endmember mantle flow models (two-dimensional entrained flow vs. three-dimensional toroidal flow) and explore possible avenues for resolving the Cascadia Paradox.

The "olfactory mirror" and other recent attempts to demonstrate self-recognition in non-primate species.

PubMed

Gallup, Gordon G; Anderson, James R

2018-03-01

The recent attempt by Horowitz (2017) to develop an "olfactory mirror" test of self-recognition in domestic dogs raises some important questions about the kinds of data that are required to provide definitive evidence for self-recognition in dogs and other species. We conclude that the "olfactory mirror" constitutes a compelling analog to the mark test for mirror self-recognition in primates, but despite claims to the contrary neither dogs, elephants, dolphins, magpies, horses, manta rays, squid, nor ants have shown compelling, reproducible evidence for self-recognition in any modality. Copyright © 2017 Elsevier B.V. All rights reserved.

Dan Says - Continuum Magazine | NREL

Science.gov Websites

provide incisive insights into the latest and most impactful clean energy innovations, while spotlighting compelling and a useful look into NREL's ongoing contributions to our collective energy future. Dr. Dan E

Exploring Physics with Computer Animation and PhysGL

NASA Astrophysics Data System (ADS)

Bensky, T. J.

2016-10-01

This book shows how the web-based PhysGL programming environment (http://physgl.org) can be used to teach and learn elementary mechanics (physics) using simple coding exercises. The book's theme is that the lessons encountered in such a course can be used to generate physics-based animations, providing students with compelling and self-made visuals to aid their learning. Topics presented are parallel to those found in a traditional physics text, making for straightforward integration into a typical lecture-based physics course. Users will appreciate the ease at which compelling OpenGL-based graphics and animations can be produced using PhysGL, as well as its clean, simple language constructs. The author argues that coding should be a standard part of lower-division STEM courses, and provides many anecdotal experiences and observations, that include observed benefits of the coding work.

American Akicita: Indigenous American warriors and military service.

PubMed

McDonald, J Douglas

2017-08-01

Indigenous Americans (i.e., Native/American Indians, AK natives, Pacific Islanders) have consistently volunteered for military service at greater rates than any other ethnic group, including the majority culture, since the early days of the country. This article is an introduction to the special section which includes a number of outstanding papers that provide an innovative and compelling effort to overcome the challenges of casualties from war and render effective and culturally informed care. These manuscripts describe culturally appropriate considerations of suicide (O'Keefe), family involvement and access to care (Whealin), and telehealth for treatment of rural Native veterans (Goss). Challenging and complex treatment needs call for equally mindful and competent approaches. These authors and providers present compelling examples of addressing these needs in working with our Wounded Warriors. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Girls' Sexual Development in the Inner City: From Compelled Childhood Sexual Contact to Sex-for-Things Exchanges

ERIC Educational Resources Information Center

Dunlap, Eloise; Golub, Andrew; Johnson, Bruce D.

2003-01-01

Child Sexual Abuse (CSA) has been linked to a wide variety of adverse psychological and behavioral outcomes. This paper describes girls' sexual development in the inner city based on qualitative material from a long-term ethnographic (observational) study. For many inner-city girls, early and then continued experiences of being compelled to have…

Developing Sustainable Digital Libraries: Socio-Technical Perspectives

ERIC Educational Resources Information Center

Ashraf, Tariq, Ed.; Sharma, Jaideep, Ed.; Gulati, Puja Anand, Ed.

2010-01-01

The increasing prevalence of digital information systems and technologies compels libraries across the globe to update systems and provide users with a digital experience outside the confines of the structural library, providing useful benefits to the user while creating new areas of concern such as digital information preservation.…

Yesterday, Today, and Tomorrow: School Desegregation and Resegregation in Charlotte

ERIC Educational Resources Information Center

Mickelson, Roslyn Arlin, Ed.; Smith, Stephen Samuel, Ed.; Nelson, Amy Hawn, Ed.

2015-01-01

"Yesterday, Today, and Tomorrow" provides a compelling analysis of the forces and choices that have shaped the trend toward the resegregation of public schools. By assembling a wide range of contributors--historians, sociologists, economists, and education scholars--the editors provide a comprehensive view of a community's experience…

Ten tips for successful electronic health records deployment.

PubMed

Gasch, Art

2012-01-01

As healthcare providers are increasingly compelled to adopt electronic health records (EHRs) and paper records migrate to electronic files provided to dozens of healthcare intermediaries, breeches of protected health information are skyrocketing, and so are dissatisfaction rates with EHR solutions. This article provides 10 practical tips to ensure a successful EHR system deployment an circumvent EHR land mines.

Know Stroke: Know the Signs, Act in Time Video

MedlinePlus Videos and Cool Tools

... of the National Institutes of Health For more information about stroke, please call 1-800-352-9424 ... Merino. This 13 minute Spanish video provides critical information about stroke prevention and treatment through the compelling, ...

Convergent dysregulation of frontal cortical cognitive and reward systems in eating disorders.

PubMed

Stefano, George B; Ptáček, Radek; Kuželová, Hana; Mantione, Kirk J; Raboch, Jiří; Papezova, Hana; Kream, Richard M

2013-05-10

A substantive literature has drawn a compelling case for the functional involvement of mesolimbic/prefrontal cortical neural reward systems in normative control of eating and in the etiology and persistence of severe eating disorders that affect diverse human populations. Presently, we provide a short review that develops an equally compelling case for the importance of dysregulated frontal cortical cognitive neural networks acting in concert with regional reward systems in the regulation of complex eating behaviors and in the presentation of complex pathophysiological symptoms associated with major eating disorders. Our goal is to highlight working models of major eating disorders that incorporate complementary approaches to elucidate functionally interactive neural circuits defined by their regulatory neurochemical phenotypes. Importantly, we also review evidence-based linkages between widely studied psychiatric and neurodegenerative syndromes (e.g., autism spectrum disorders and Parkinson's disease) and co-morbid eating disorders to elucidate basic mechanisms involving dopaminergic transmission and its regulation by endogenously expressed morphine in these same cortical regions.

Healthy body, healthy mind?: the effectiveness of physical activity to treat ADHD in children.

PubMed

Halperin, Jeffrey M; Berwid, Olga G; O'Neill, Sarah

2014-10-01

Data from animal studies provide convincing evidence that physical exercise enhances brain development and neurobehavioral functioning in areas believed to be impaired in children with attention-deficit/hyperactivity disorder (ADHD). To a lesser but still compelling extent, results from studies in typically developing children and adults indicate beneficial effects of exercise on many of the neurocognitive functions that have been shown to be impaired in children with ADHD. Together, these data provide a strong rationale for why a program of structured physical exercise might serve as an effective intervention for children with ADHD. Copyright © 2014 Elsevier Inc. All rights reserved.

Collaboration for Education with the Apple Learning Interchange

NASA Astrophysics Data System (ADS)

Young, Patrick A.; Zimmerman, T.; Knierman, K. A.

2006-12-01

We present a progressive effort to deliver online education and outreach resources in collaboration with the Apple Learning Interchange, a free community for educators. We have created a resource site with astronomy activities, video training for the activities, and the possibility of interactive training through video chat services. Also in development is an online textbook for graduate and advanced undergraduate courses in stellar evolution, featuring an updatable and annotated text with multimedia content, online lectures, podcasts, and a framework for interactive simulation activities. Both sites will be highly interactive, combining online discussions, the opportunity for live video interaction, and a growing library of student work samples. This effort promises to provide a compelling model for collaboration between science educators and corporations. As scientists, we provide content knowledge and a compelling reason to communicate, while Apple provides technical expertise, a deep knowledge of online education, and a way for us to reach a wide audience of higher education, community outreach, and K-12 educators.

On the lack of evidence that non-human animals possess anything remotely resembling a 'theory of mind'.

PubMed

Penn, Derek C; Povinelli, Daniel J

2007-04-29

After decades of effort by some of our brightest human and non-human minds, there is still little consensus on whether or not non-human animals understand anything about the unobservable mental states of other animals or even what it would mean for a non-verbal animal to understand the concept of a 'mental state'. In the present paper, we confront four related and contentious questions head-on: (i) What exactly would it mean for a non-verbal organism to have an 'understanding' or a 'representation' of another animal's mental state? (ii) What should (and should not) count as compelling empirical evidence that a non-verbal cognitive agent has a system for understanding or forming representations about mental states in a functionally adaptive manner? (iii) Why have the kind of experimental protocols that are currently in vogue failed to produce compelling evidence that non-human animals possess anything even remotely resembling a theory of mind? (iv) What kind of experiments could, at least in principle, provide compelling evidence for such a system in a non-verbal organism?

Perceptual Organization of Visual Structure Requires a Flexible Learning Mechanism

ERIC Educational Resources Information Center

Aslin, Richard N.

2011-01-01

Bhatt and Quinn (2011) provide a compelling and comprehensive review of empirical evidence that supports the operation of principles of perceptual organization in young infants. They also have provided a comprehensive list of experiences that could serve to trigger the learning of at least some of these principles of perceptual organization, and…

Simulation Genres and Student Uptake: The Patient Health Record in Clinical Nursing Simulations

ERIC Educational Resources Information Center

Campbell, Lilly

2017-01-01

Drawing on fieldwork, this article examines nursing students' design and use of a patient health record during clinical simulations, where small teams of students provide nursing care for a robotic patient. The student-designed patient health record provides a compelling example of how simulation genres can both authentically coordinate action…

Storyline Visualization: A Compelling Way to Understand Patterns over Time and Space

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2017-10-16

Storyline visualization is a compelling way to understand patterns over time and space. Much effort has been spent developing efficient and aesthetically pleasing layout optimization algorithms. But what if those algorithms are optimizing the wrong things? To answer this question, we conducted a design study with different storyline layout algorithms. We found that users with our new design principles for storyline visualization outperform existing methods.

Traffic records needs of local governments in Virginia.

DOT National Transportation Integrated Search

1975-01-01

The state of Virginia has a unilateral traffic records system whereby localities are compelled by law to provide law enforcement information to the state without any assurance that usable information will be returned to the localities. This situation...

13 CFR 303.4 - Award requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PLANNING INVESTMENTS AND COMPREHENSIVE ECONOMIC DEVELOPMENT STRATEGIES § 303.4 Award requirements. (a) Planning Investments shall function in conjunction with any other available Federal, State or local... compelling circumstances as determined by the Assistant Secretary, EDA will not provide Planning Investments...

43 CFR 4.1135 - Motion to compel discovery.

Code of Federal Regulations, 2013 CFR

2013-10-01

... a motion made pursuant to this section, the administrative law judge may make such a protective... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Motion to compel discovery. 4.1135 Section... Motion to compel discovery. (a) If a deponent fails to answer a question propounded, or a party upon whom...

43 CFR 4.1135 - Motion to compel discovery.

Code of Federal Regulations, 2014 CFR

2014-10-01

... a motion made pursuant to this section, the administrative law judge may make such a protective... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Motion to compel discovery. 4.1135 Section... Motion to compel discovery. (a) If a deponent fails to answer a question propounded, or a party upon whom...

Methods Used in Game Development to Foster FLOW

NASA Technical Reports Server (NTRS)

Jeppsen, Isaac Ben

2010-01-01

Games designed for entertainment have a rich history of providing compelling experiences. From consoles to PCs, games have managed to present intuitive and effective interfaces for a wide range of game styles to successfully allow users to "walk-up-and-play". Once a user is hooked, successful games artfully present challenging experiences just within reach of a user's ability, weaving each task and achievement into a compelling and engaging experience. In this paper, engagement is discussed in terms of the psychological theory of Flow. I argue that engagement should be one of the primary goals when developing a serious game and I discuss the best practices and techniques that have emerged from traditional video game development which help foster the creation of engaging, high Flow experiences.

When Sleep Isn’t Perfect: Risk and Resilience for Cognitive Consquences of Imperfect Sleep Duration and Suboptimal Timing of Tasks in Circadian Rhythm

DTIC Science & Technology

2017-07-01

Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a...progress in our work with the industry collaborator providing data to meet our study aims. Preliminary analyses of sleep and cognitive performance data...have yielded compelling findings with respect to sleep duration and cognitive performance across the lifespan. These now published findings

29 CFR 18.21 - Motion to compel discovery.

Code of Federal Regulations, 2011 CFR

2011-07-01

... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.21 Motion to compel discovery. (a) If a deponent fails... to answer or respond. (d) In ruling on a motion made pursuant to this section, the administrative law... 29 Labor 1 2011-07-01 2011-07-01 false Motion to compel discovery. 18.21 Section 18.21 Labor...

29 CFR 18.21 - Motion to compel discovery.

Code of Federal Regulations, 2012 CFR

2012-07-01

... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.21 Motion to compel discovery. (a) If a deponent fails... to answer or respond. (d) In ruling on a motion made pursuant to this section, the administrative law... 29 Labor 1 2012-07-01 2012-07-01 false Motion to compel discovery. 18.21 Section 18.21 Labor...

29 CFR 18.21 - Motion to compel discovery.

Code of Federal Regulations, 2013 CFR

2013-07-01

... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.21 Motion to compel discovery. (a) If a deponent fails... to answer or respond. (d) In ruling on a motion made pursuant to this section, the administrative law... 29 Labor 1 2013-07-01 2013-07-01 false Motion to compel discovery. 18.21 Section 18.21 Labor...

29 CFR 18.21 - Motion to compel discovery.

Code of Federal Regulations, 2014 CFR

2014-07-01

... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.21 Motion to compel discovery. (a) If a deponent fails... to answer or respond. (d) In ruling on a motion made pursuant to this section, the administrative law... 29 Labor 1 2014-07-01 2013-07-01 true Motion to compel discovery. 18.21 Section 18.21 Labor Office...

Effectiveness of violator penalties in compelling compliance with state truck weight limits

DOT National Transportation Integrated Search

1997-01-01

This is the 1997 edition of a series of reports required by Congress on America's surface transportation system. The report provides information on the physical and operating characteristics of the highway, bridge, and transit portions of our Nation'...

An alternate pathway for androgen regulation of brain function: Activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5α-androstane 3β, 17β diol

PubMed Central

Handa, Robert J.; Pak, Toni R.; Kudwa, Andrea E.; Lund, Trent D.; Hinds, Laura

2008-01-01

The complexity of gonadal steroid hormone actions is reflected in their broad and diverse effects on a host of integrated systems including reproductive physiology, sexual behavior, stress responses, immune function, cognition, and neural protection. Understanding the specific contributions of androgens and estrogens in neurons that mediate these important biological processes is central to the study of neuroendocrinology. Of particular interest in recent years has been the biological role of androgen metabolites. The goal of this review is to highlight recent data delineating the specific brain targets for the dihydrotestosterone metabolite, 5α-androstane, 3β, 17β-diol (3β-Diol). Studies using both in vitro and in vivo approaches provide compelling evidence that 3β-Diol is an important modulator of the stress response mediated by the hypothalmo-pituitary-adrenal axis. Further, the actions of 3β-Diol are mediated by estrogen receptors, and not androgen receptors, often through a canonical estrogen response element in the promoter of a given target gene. These novel findings compel us to re-evaluate the interpretation of past studies and the design of future experiments aimed at elucidating the specific effects of androgen receptor signaling pathways. PMID:18067894

Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement.

PubMed

Griffiths, R R; Chausmer, A L

2000-11-01

Caffeine is an excellent model compound for understanding drugs of abuse/dependence. The results of self-administration and choice studies in humans clearly demonstrate the reinforcing effects of low and moderate doses of caffeine. Caffeine reinforcement has been demonstrated in about 45% of normal subjects with histories of moderate and heavy caffeine use. Recent studies provide compelling evidence that caffeine physical dependence potentiates the reinforcing effects of caffeine through the mechanism of withdrawal symptom avoidance. Tolerance to the subjective and sleep-disrupting effects of caffeine in humans has been demonstrated. Physical dependence as reflected in a withdrawal syndrome in humans has been repeatedly demonstrated in adults and recently demonstrated in children. Withdrawal severity is an increasing function of caffeine maintenance dose, with withdrawal occurring at doses as low as 100 mg per day. Increased cerebral blood flow may be the physiological mechanism for caffeine withdrawal headache. Case studies in adults and adolescents clearly demonstrate that some individuals meet DSM-IV diagnostic criteria for a substance dependence syndrome on caffeine, including feeling compelled to continue caffeine use despite desires and recommendations to the contrary. Survey data suggest that 9% to 30% percent of caffeine consumers may be caffeine dependent according to DSM-IV criteria.

Developing Cognitive Models for Social Simulation from Survey Data

NASA Astrophysics Data System (ADS)

Alt, Jonathan K.; Lieberman, Stephen

The representation of human behavior and cognition continues to challenge the modeling and simulation community. The use of survey and polling instruments to inform belief states, issue stances and action choice models provides a compelling means of developing models and simulations with empirical data. Using these types of data to population social simulations can greatly enhance the feasibility of validation efforts, the reusability of social and behavioral modeling frameworks, and the testable reliability of simulations. We provide a case study demonstrating these effects, document the use of survey data to develop cognitive models, and suggest future paths forward for social and behavioral modeling.

45 CFR 164.103 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... contained in law that compels an entity to make a use or disclosure of protected health information and that... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS... health plan, health care provider, or health care clearinghouse. Health care component means a component...

45 CFR 164.103 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... contained in law that compels an entity to make a use or disclosure of protected health information and that... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS... health plan, health care provider, or health care clearinghouse. Health care component means a component...

Piaget and Middle School Mathematics.

ERIC Educational Resources Information Center

Juraschek, William

1983-01-01

This discussion is primarily designed to increase teachers' awareness of Piaget's theory of cognitive development and implications for mathematics in the middle school. It is hoped such awareness will compel instructors to adopt strategies that help pupils gain more from mathematical experiences, by providing impetus for innovation and…

Reconstruing U-Shaped Functions

ERIC Educational Resources Information Center

Werker, Janet F.; Hall, D. Geoffrey; Fais, Laurel

2004-01-01

U-shaped developmental functions, and their N-shaped cousins, have intrigued developmental psychologists for decades because they provide a compelling demonstration that development does not always entail a monotonic increase across age in a single underlying ability. Instead, the causes of development are much more complex. Indeed,…

Teachers and Children Inquire into Reggio Emilia

ERIC Educational Resources Information Center

Clyde, Jean Anne; Miller, Carol; Sauer, Stacy; Liebert, Karen; Parker, Susan; Runyan, Sarah

2006-01-01

"Reggio Emilia" is a remarkable, interdisciplinary inquiry-based approach typically found in preschools. What happens when elementary teachers confined by curricular mandates embrace key features of this learner-centered philosophy? This article provides compelling evidence that when multiple literacies are harnessed in support of inquiry, the…

Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome.

PubMed

Dölen, Gül; Bear, Mark F

2008-03-15

Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of fragile X and related disorders.

Chromosome Territories

PubMed Central

Cremer, Thomas; Cremer, Marion

2010-01-01

Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief statement, the possible contribution of nuclear architecture studies to the field of epigenomics is considered, followed by a historical account of the CT concept and the final compelling experimental evidence of a territorial organization of chromosomes in all eukaryotes studied to date. Present knowledge of nonrandom CT arrangements, of the internal CT architecture, and of structural interactions with other CTs is provided as well as the dynamics of CT arrangements during cell cycle and postmitotic terminal differentiation. The article concludes with a discussion of open questions and new experimental strategies to answer them. PMID:20300217

The Toxicant-Target Paradigm for Toxicity Screening – Pharmacophore Based Constraints

EPA Science Inventory

There is a compelling need to develop information for the screening and prioritization of the health and environmental effects of large numbers of man-made chemicals. Knowledge of the potential pathways for activity provides a rational basis for the preliminary evaluation of ris...

Development of Prosocial Skills. Final Report

ERIC Educational Resources Information Center

Parrila, Rauno K.; Ma, Xin; Fleming, Darcy; Rinaldi, Christina

2002-01-01

In part, this focus is a result of substantial research demonstrating strong links between early social competence and later life adjustment and healthy development. The close connection between prosocial skills and a wide variety of future developmental outcomes provides a compelling rationale to examine what factors are associated with…

Transforming First-Year Learning Experiences to Enhance Success for At-Risk Undergraduates

ERIC Educational Resources Information Center

Zander, Douglas; Mack, Nakia; Aviles, Jose; Corkery, Caleb; Shettel, Jennifer; Prabhu,Vilas; Shibley, Lisa

2013-01-01

The Millersville Scholars Program at Millersville University of Pennsylvania, located in the Southeastern Pennsylvania metropolitan area, provides a compelling best practice for transition programs that address the specific needs of underprepared students so their success mirrors success rates of well-prepared students.

Unleashing Latent Ability: Implications of Stereotype Threat for College Admissions

ERIC Educational Resources Information Center

Logel, Christine R.; Walton, Gregory M.; Spencer, Steven J.; Peach, Jennifer; Mark, Zanna P.

2012-01-01

Social-psychological research conducted over the past 15 years provides compelling evidence that pervasive psychological threats are present in common academic environments--especially threats that originate in negative intellectual stereotypes--and that these threats undermine the real-world academic performance of non-Asian ethnic minority…

Democratic Leadership in Education

ERIC Educational Resources Information Center

Woods, Philip A.

2005-01-01

In this book Philip Woods turns his attention to issues of democracy and leadership. He has provided an eloquent, intellectually compelling and sophisticated account of a new leadership label--democratic leadership. He argues that the purpose of "democratic" leadership is to create and help sustain an environment that enables everyone…

Getting started with the model for improvement: psychology and leadership in quality improvement.

PubMed

Pratap, J Nick; Varughese, Anna M; Adler, Elena; Kurth, C Dean

2013-02-01

Although the case for quality in hospitals is compelling, doctors are often uncertain how to achieve it. This article forms the third and final part of a series providing practical guidance on getting started with a first quality improvement project. Introduction.

The Condition of College Readiness, 2009

ERIC Educational Resources Information Center

ACT, Inc., 2009

2009-01-01

Since 1959, ACT has collected and reported data on students' academic readiness for college. Because becoming ready for college is a process that occurs throughout elementary and secondary education, measuring academic performance over time in the context of college readiness provides meaningful and compelling information about the college…

Noise-Induced Hearing Loss (NIHL).

ERIC Educational Resources Information Center

Seidman, Michael D.

1999-01-01

This article provides an overview of noise-induced hearing loss (NIHL), the leading cause of occupationally induced hearing loss in industrialized countries. It discusses causes of NIHL and compelling evidence that reactive oxygen metabolites and cochlear hypoprefusion are responsible for the destruction of cochlear hair cells. Prevention is also…

Synaptic communication between neurons and NG2+ cells.

PubMed

Paukert, Martin; Bergles, Dwight E

2006-10-01

Chemical synaptic transmission provides the basis for much of the rapid signaling that occurs within neuronal networks. However, recent studies have provided compelling evidence that synapses are not used exclusively for communication between neurons. Physiological and anatomical studies indicate that a distinct class of glia known as NG2(+) cells also forms direct synaptic junctions with both glutamatergic and GABAergic neurons. Glutamatergic signaling can influence intracellular Ca(2+) levels in NG2(+) cells by activating Ca(2+) permeable AMPA receptors, and these inputs can be potentiated through high frequency stimulation. Although the significance of this highly differentiated form of communication remains to be established, these neuro-glia synapses might enable neurons to influence rapidly the behavior of this ubiquitous class of glial progenitors.

Destination Media Center: How to Provide an Orientation to Make Sure Patrons Are Headed in the Right Direction

ERIC Educational Resources Information Center

Purcell, Melissa

2011-01-01

The school library media center should be a place that every student and teacher feels compelled to visit on a daily basis. Offering good, informative orientations can provide the direction needed to ensure that happens. Orientations should be part of every school library media specialist's job description and role. Orientations can be as long or…

Wilderness management within an Australian interstate context

Treesearch

J. Elkinton

2015-01-01

Conservation, reserve management within an interstate context is not unique in or to Australia. Nevertheless, the policy and procedures derived from various, state legislation often creates ambiguity for interstate, land management agencies. This compels such agencies to adopt specific approaches and strategies to landscape management. This paper provides a context for...

Commentary on Sowcik and Allen: Getting Down to Business

ERIC Educational Resources Information Center

Murphy, Susan Elaine

2013-01-01

Sowcik and Allen's paper, "Getting Down to Business: A Look at Leadership Education in Business Schools," identifies a number of compelling issues in improving leadership education in business schools and provides a thorough overview of how these efforts could benefit from the considerations present in the National Leadership Educators…

Cell biology: at the center of modern biomedicine.

PubMed

Budde, Priya Prakash; Williams, Elizabeth H; Misteli, Tom

2012-10-01

How does basic cell biology contribute to biomedicine? A new series of Features in JCB provides a cross section of compelling examples of how basic cell biology findings can lead to therapeutics. These articles highlight the fruitful, essential, and increasingly prominent bridge that exists between cell biology and the clinic.

22 CFR 92.10 - Specific waiver in notarial certificate.

Code of Federal Regulations, 2010 CFR

2010-04-01

... officer has reason to believe that material statements in a document presented for notarization are false... frivolous statements: Provided, That substantial and compelling reasons do not exist which impel restraining...) executed in connection with divorce proceedings. [22 FR 10858, Dec. 27, 1957, as amended at 60 FR 51723...

Virtual Education and the Race to the Bottom

ERIC Educational Resources Information Center

Versluis, Arthur

2004-01-01

The president of a vastly profitable virtual education corporation asserted that customers flock to him, not for an education, but for the material comforts that an education provides. Compelled by technology and supported by the World Trade Organization, such huge credentialing agencies employ lowpaid contractors to dish out homogenized info…

What Can K-12 School Leaders Learn from Video Games and Gaming?

ERIC Educational Resources Information Center

Halverson, Richard

2005-01-01

Schools have much to learn from video games and the gaming community. By providing compelling activities for motivating otherwise indifferent learners, video games can potentially help teachers improve the design of learning environments. However, there are considerable rhetorical and practical barriers between the schooling and gaming communities…

Directions in nutritional assessment: Biomarkers and bio-indicators - providing clarity in the face of complexity

USDA-ARS?s Scientific Manuscript database

Among the greatest challenges facing the Nutrition community is integrating nutrition into all aspects of global efforts in health promotion and disease prevention. Despite compelling evidence of its importance to human development, a full appreciation of how nutrition affects health is still lackin...

E-Coaching Systems: Convenient, Anytime, Anywhere, and Nonhuman

ERIC Educational Resources Information Center

Warner, Teri

2012-01-01

Technologies continue to evolve to provide more compelling and interactive learning opportunities. Coaching has traditionally been face-to-face or by email. By combining the new technologies with coaching, learning developers now have the opportunity to develop an asynchronous, online, nonhuman coaching system, or e-coaching system. An e-coaching…

Black Women and Homeownership: The Financial Challenge of the '80s.

ERIC Educational Resources Information Center

Better, Shirley

1979-01-01

States that changes in the economy, employment, family composition, and social attitudes now compel more Black women into howeownership. Reports that homeownership by Blacks prevents urban blight and gives Blacks more political power. Provides sources of information on mortgage credit and redress for discrimination. (Author/WP)

The Condition of College & Career Readiness, 2010

ERIC Educational Resources Information Center

ACT, Inc., 2010

2010-01-01

Since 1959, ACT has collected and reported data on students' academic readiness for college. Because becoming ready for college and career is a process that occurs throughout elementary and secondary education, measuring academic performance over time in the context of college and career readiness provides meaningful and compelling information…

Promoting Competence and Resilience in the School Context

ERIC Educational Resources Information Center

Masten, Ann S.; Herbers, Janette E.; Cutuli, J. J.; Lafavor, Theresa L.

2008-01-01

Four decades of research on resilience in young people provide compelling data and models for applications in the school context. Resilience theory and findings are highly congruent with Strengths-Based School Counseling (SBSC) as formulated by Galassi and Akos (2007). In this article, resilience is defined in relation to competence in…

IGF-1: elixir for motor neuron diseases.

PubMed

Papanikolaou, Theodora; Ellerby, Lisa M

2009-08-13

Modulation of testosterone levels is a therapeutic approach for spinal and bulbar muscular atrophy (SBMA), a polyglutamine disorder that affects the motor neurons. The article by Palazzolo et al. in this issue of Neuron provides compelling evidence that the expression of insulin growth hormone is a potential therapeutic for SBMA.

Converging cellular themes for the hereditary spastic paraplegias.

PubMed

Blackstone, Craig

2018-05-10

Hereditary spastic paraplegias (HSPs) are neurologic disorders characterized by prominent lower-extremity spasticity, resulting from a length-dependent axonopathy of corticospinal upper motor neurons. They are among the most genetically-diverse neurologic disorders, with >80 distinct genetic loci and over 60 identified genes. Studies investigating the molecular pathogenesis underlying HSPs have emphasized the importance of converging cellular pathogenic themes in the most common forms of HSP, providing compelling targets for therapy. Most notably, these include organelle shaping and biogenesis as well as membrane and cargo trafficking. Published by Elsevier Ltd.

Measurement of inflammation and oxidative stress following drastic changes in air pollution during the Beijing Olympics: a panel study approach

PubMed Central

Kipen, Howard; Rich, David; Huang, Wei; Zhu, Tong; Wang, Guangfa; Hu, Min; Lu, Shou-en; Ohman-Strickland, Pamela; Zhu, Ping; Wang, Yuedan; Zhang, Jim (Junfeng)

2014-01-01

Ambient air pollution has been linked to cardiovascular and respiratory morbidity and mortality in epidemiology studies. Frequently, oxidative and nitrosative stress are hypothesized to mediate these pollution effects, however precise mechanisms remain unclear. This paper describes the methodology for a major panel study to examine air pollution effects on these and other mechanistic pathways. The study took place during the drastic air pollution changes accompanying the 2008 Olympics in Beijing, China. After a general description of air pollution health effects, we provide a discussion of panel studies and describe the unique features of this study that make it likely to provide compelling results. This study should lead to a clearer and more precise definition of the role of oxidative and nitrosative stress, as well as other mechanisms, in determining acute morbidity and mortality from air pollution exposure. PMID:20716299

Tool bending in New Caledonian crows.

PubMed

Rutz, Christian; Sugasawa, Shoko; van der Wal, Jessica E M; Klump, Barbara C; St Clair, James J H

2016-08-01

'Betty' the New Caledonian crow astonished the world when she 'spontaneously' bent straight pieces of garden wire into hooked foraging tools. Recent field experiments have revealed that tool bending is part of the species' natural behavioural repertoire, providing important context for interpreting Betty's iconic wire-bending feat. More generally, this discovery provides a compelling illustration of how natural history observations can inform laboratory-based research into the cognitive capacities of non-human animals.

30 CFR 775.11 - Administrative review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... affirmations, subpoena witnesses and written or printed materials, compel attendance of witnesses or production of those materials, compel discovery, and take evidence, including, but not limited to, site...

Twins and transsexualism: an update and a preview; research reviews: conjoined twins, angiographic lesions, single versus double embryo transfer; headlines: school placement legislation, Junior Taekwondo Olympics, prosthetic ears, murder victim.

PubMed

Segal, Nancy L

2007-12-01

In recent years, there has been growing appreciation for the complexity of gender identity. Focusing on monozygotic (MZ) twins discordant for transsexualism can offer clues to events that may trigger this behavioral difference, offering new information about critical underlying factors. An update of twin research in this area is provided, together with a preview of a compelling new film, 'Red Without Blue.' Next, twin study findings on the topics of conjoined twinning, angiographic lesions and embryo transfer are provided. This is followed by a survey of newsworthy twins and twin-related events.

28 CFR 0.177a - Antitrust civil investigative demands.

Code of Federal Regulations, 2010 CFR

2010-07-01

... JUSTICE Assigning Responsibility Concerning Applications for Orders Compelling Testimony or Production of..., United States Code, to compel testimony in response to antitrust civil investigative demands for oral...

Wyoming Landscape Conservation Initiative—A case study in partnership development

USGS Publications Warehouse

D'Erchia, Frank

2016-10-21

The Wyoming Landscape Conservation Initiative (WLCI) is a successful example of collaboration between science and natural resource management at the landscape scale. In southwestern Wyoming, expanding energy and mineral development, urban growth, and other changes in land use over recent decades, combined with landscape-scale drivers such as climate change and invasive species, have presented compelling challenges to resource managers and a diverse group of Federal, State, industry, and non-governmental organizations, as well as citizen stakeholders. To address these challenges, the WLCI was established as a collaborative forum and interagency partnership to develop and implement science-based conservation actions. About a decade after being established, this report documents the establishment and history of the WLCI, focusing on the path to success of the initiative and providing insights and details that may be useful in developing similar partnerships in other locations. Not merely retrospective, the elements of the WLCI that are presented herein are still in play, still evolving, and still contributing to the resolution of compelling conservation challenges in the Western United States.The U.S. Geological Survey has developed many successful longstanding partnerships, of which the WLCI is one example.“As the Nation’s largest water, earth, and biological science and civilian mapping agency, the U.S. Geological Survey collects, monitors, analyzes, and provides scientific understanding about natural resource conditions, issues, and problems. The diversity of our scientific expertise enables us to carry out large-scale, multi-disciplinary investigations and provide impartial scientific information to resource managers, planners, and other customers” (U.S. Geological Survey, 2016).

Integrated play groups: promoting symbolic play and social engagement with typical peers in children with ASD across settings.

PubMed

Wolfberg, Pamela; DeWitt, Mila; Young, Gregory S; Nguyen, Thanh

2015-03-01

Children with autism spectrum disorders (ASD) face pervasive challenges in symbolic and social play development. The Integrated Play Groups (IPG) model provides intensive guidance for children with ASD to participate with typical peers in mutually engaging experiences in natural settings. This study examined the effects of a 12-week IPG intervention on the symbolic and social play of 48 children with ASD using a repeated measures design. The findings revealed significant gains in symbolic and social play that generalized to unsupported play with unfamiliar peers. Consistent with prior studies, the outcomes provide robust and compelling evidence that further validate the efficacy of the IPG model. Theoretical and practical implications for maximizing children's developmental potential and social inclusion in play are discussed.

Peirce, Pragmatism, and Religious Education: Participating More Deeply in God's Imagination

ERIC Educational Resources Information Center

Falcone, John P.

2016-01-01

Approaching Christian education in light of Charles Sanders Peirce's Classical Pragmatism can help catechists make Christian tradition more intelligible to present-day North Americans; it can provide them with a rich framework for pedagogical practices; and it can help them offer a compelling vision of deeper participation in the Trinitarian life…

The Power of Story in Science Learning.

ERIC Educational Resources Information Center

Lauritzen, Carol; Jaeger, Michael

Jill Paton Walsh's "The Green Book," the story of a group of humans and their life on a new planet, captures the imagination of learners and provides a compelling context for learning. Several groups of learners including fifth graders and adult teacher practitioners responded to the book in unique and interesting ways. As the setting,…

Systematic review of the influence of foraging habitat on red-cockaded woodpecker reproductive success

Treesearch

James E. Garabedian; Christopher E. Moorman; M. Nils Peterson; John C. Kilgo

2014-01-01

Relationships between foraging habitat and reproductive success provide compelling evidence of the contribution of specific vegetative features to foraging habitat quality, a potentially limiting factor for many animal populations. For example, foraging habitat quality likely will gain importance in the recovery of the threatened red-cockaded woodpecker Picoides...

Testing for Accountability: A Balancing Act That Challenges Current Testing Practices and Theories

ERIC Educational Resources Information Center

Brennan, Robert L.

2015-01-01

Koretz, in his article published in this issue, provides compelling arguments that the high stakes currently associated with accountability testing lead to behavioral changes in students, teachers, and other stakeholders that often have negative consequences, such as inflated scores. Koretz goes on to argue that these negative consequences require…

Modules, Theories, or Islands of Expertise? Domain Specificity in Socialization

ERIC Educational Resources Information Center

Gelman, Susan A.

2010-01-01

The domain-specific approach to socialization processes presented by J. E. Grusec and M. Davidov (this issue) provides a compelling framework for integrating and interpreting a large and disparate body of research findings, and it generates a wealth of testable new hypotheses. At the same time, it introduces core theoretical questions regarding…

Early Domain-Specific Knowledge? Nonlinear Developmental Trajectories Further Erode a House of Sand

ERIC Educational Resources Information Center

Deak, Gedeon O.

2011-01-01

Rakison and Yermolayeva (this issue) argue that domain specificity is difficult to reconcile with U-, N-, or M-shaped developmental trends. They are justified because: (1) There is no compelling evidence that nonlinear trends require mechanisms beyond general, well-known cognitive processes; and (2) epigenetic neuroscience provides no clear…

Poverty Matters: The Cost of Child Poverty in America.

ERIC Educational Resources Information Center

Sherman, Arloc

The poverty affecting 14.5 million U.S. children living below the poverty line poses long-term effects, including risks to health, educational achievement, family stability, and employment prospects. This report provides compelling evidence of the substantial costs of poverty among children to our nation's economic well-being, and shows that…

The Rising Cost of "Not" Going to College

ERIC Educational Resources Information Center

Morin, Rich; Brown, Anna; Fry, Rick

2014-01-01

For those who question the value of college in this era of soaring student debt and high unemployment, the attitudes and experiences of today's young adults--members of the so-called Millennial generation--provide a compelling answer. On virtually every measure of economic well-being and career attainment--from personal earnings to job…

The Almanac of American Education, 2013. Seventh Edition. U.S. DataBook Series

ERIC Educational Resources Information Center

Gaquin, Deirdre A., Ed.; Dunn, Gwenavere W., Ed.

2013-01-01

The "Almanac of American Education" helps users understand and compare the quality of education at the national, state, and county levels. Compiled from official U.S. government and reliable private sources, the book contains historical and current data, insightful analysis, and useful graphs that provide compelling insights into the…

The Almanac of American Education, 2014-2015. Eighth Edition. U.S. DataBook Series

ERIC Educational Resources Information Center

Gaquin, Deirdre A., Ed.; Dunn, Gwenavere W., Ed.

2015-01-01

The "Almanac of American Education" helps users understand and compare the quality of education at the national, state, and county levels. Compiled from official U.S. government and reliable private sources, the book contains historical and current data, insightful analysis, and useful graphs that provide compelling insights into the…

Social Fatherhood: Conceptualizations, Compelling Research, and Future Directions.

ERIC Educational Resources Information Center

Day, Randal D.

Noting that the research literature about father involvement is expanding at an exponential rate, this paper explores seminal ideas about father involvement in families. The paper is presented in three parts. The first part provides an overview of the emerging research on social fatherhood. This part traces the changes in the concept of fatherhood…

Baseline Report on HB2320

ERIC Educational Resources Information Center

State Council of Higher Education for Virginia, 2015

2015-01-01

Staff provides this baseline report as a summary of its preliminary considerations and initial research in fulfillment of the requirements of HB2320 from the 2015 session of the General Assembly. Codified as § 23-7.4:7, this legislation compels the Education Secretary and the State Council of Higher Education for Virginia (SCHEV) Director, in…

Market Failures and the Rationale for National Parks.

ERIC Educational Resources Information Center

Turner, Robert W.

2002-01-01

Discusses how market failures can, in principle, be used to justify national parks. States the best rationale is based on existence or nonuse values instead of the recreational aspects. Shows more evidence (costs of providing and operating the parks and the magnitude of nonuse values) is needed before the case becomes compelling. (JEH)

The Power of Music in the Lives of Older Adults

ERIC Educational Resources Information Center

Creech, Andrea; Hallam, Susan; McQueen, Hilary; Varvarigou, Maria

2013-01-01

A compelling body of research demonstrates that music continues to offer powerful potential for enhancing health and well-being in old age. Active music-making has been found to provide a source of enhanced social cohesion, enjoyment, personal development, and empowerment, and to contribute to recovery from depression and maintenance of personal…

Presaging Plowden: An Introduction to the Hadow Reports

ERIC Educational Resources Information Center

Gillard, Derek

2007-01-01

The author provides notes on the historical context and membership of the consultative committees chaired by Sir W. H. Hadow, summarises each of the six reports produced between 1923 and 1933, and assesses the extent to which they informed the development of education in England, noting that the Plowden Committee felt compelled to reiterate many…

Brown at 50: Keeping Promises

ERIC Educational Resources Information Center

Wu, Frank H.

2004-01-01

The story of Brown is compelling. Blacks and Whites alike understood that the Jim Crow system of "separate but equal" was a convenient fiction. There was no actual effort to ensure that Whites and Blacks were provided the same services. Invariably, the White schools had higher funding, better buildings, newer supplies and so on. Indeed,…

Designing and Redesigning a Framework for Assessing Students' Understanding of Foundational Fractions Concepts

ERIC Educational Resources Information Center

Mendiburo, Maria; Williams, Laura; Henson, Robert; Hasselbring, Ted

2013-01-01

The fact that research has shown that fractions are among the most difficult mathematical concepts for elementary school students to master (Behr, Harel, Post, & Lesh, 1992; Bezuk & Cramer, 1989; Moss & Case, 1999) provides a compelling motivation for research and innovation focused on improving the available assessment and…

Exploring Visual Evidence of Human Impact on the Environment with Planetary-Scale Zoomable Timelapse Video

NASA Astrophysics Data System (ADS)

Sargent, R.; Egge, M.; Dille, P. S.; O'Donnell, G. D.; Herwig, C.

2016-12-01

Visual evidence ignites curiosity and inspires advocacy. Zoomable imagery and video on a planetary scale provides compelling evidence of human impact on the environment. Earth Timelapse places the observable impact of 30+ years of human activity into the hands of policy makers, scientists, and advocates, with fluidity and speed that supports inquiry and exploration. Zoomability enables compelling narratives and ready apprehension of environmental changes, connecting human-scale evidence to regional and ecosystem-wide trends and changes. Leveraging the power of Google Earth Engine, join us to explore 30+ years of Landset 30m RGB imagery showing glacial retreat, agricultural deforestation, irrigation expansion, and the disappearance of lakes. These narratives are enriched with datasets showing planetary forest gain/loss, annual cycles of agricultural fires, global changes in the health of coral reefs, trends in resource extraction, and of renewable energy development. We demonstrate the intuitive and inquiry-enabling power of these planetary visualizations, and provide instruction on how scientists and advocates can create and share or contribute visualizations of their own research or topics of interest.

Recent Progress in Alzheimer’s Disease Research, Part 2: Genetics and Epidemiology

PubMed Central

Robinson, Morgan; Lee, Brenda Y.; Hane, Francis T.

2017-01-01

This is the second part of a three-part review series reviewing the most important advances in Alzheimer’s disease (AD) research since 2010. This review covers the latest research on genetics and epidemiology. Epidemiological and genetic studies are revealing important insights into the etiology of, and factors that contribute to AD, as well as areas of priority for research into mechanisms and interventions. The widespread adoption of genome wide association studies has provided compelling evidence of the genetic complexity of AD with genes associated with such diverse physiological function as immunity and lipid metabolism being implicated in AD pathogenesis. PMID:28211812

The ethics of placebo-controlled trials: methodological justifications.

PubMed

Millum, Joseph; Grady, Christine

2013-11-01

The use of placebo controls in clinical trials remains controversial. Ethical analysis and international ethical guidance permit the use of placebo controls in randomized trials when scientifically indicated in four cases: (1) when there is no proven effective treatment for the condition under study; (2) when withholding treatment poses negligible risks to participants; (3) when there are compelling methodological reasons for using placebo, and withholding treatment does not pose a risk of serious harm to participants; and, more controversially, (4) when there are compelling methodological reasons for using placebo, and the research is intended to develop interventions that can be implemented in the population from which trial participants are drawn, and the trial does not require participants to forgo treatment they would otherwise receive. The concept of methodological reasons is essential to assessing the ethics of placebo controls in these controversial last two cases. This article sets out key considerations relevant to considering whether methodological reasons for a placebo control are compelling. © 2013.

The impact of physical navigation on spatial organization for sensemaking.

PubMed

Andrews, Christopher; North, Chris

2013-12-01

Spatial organization has been proposed as a compelling approach to externalizing the sensemaking process. However, there are two ways in which space can be provided to the user: by creating a physical workspace that the user can interact with directly, such as can be provided by a large, high-resolution display, or through the use of a virtual workspace that the user navigates using virtual navigation techniques such as zoom and pan. In this study we explicitly examined the use of spatial sensemaking techniques within these two environments. The results demonstrate that these two approaches to providing sensemaking space are not equivalent, and that the greater embodiment afforded by the physical workspace changes how the space is perceived and used, leading to increased externalization of the sensemaking process.

Melvin Calvin award lecture, Isotopic chemistry: the most varied of careers…with tritium and deuterium the most versatile of the isotopes.

PubMed

Lockley, William J S

2013-01-01

Isotopic chemistry offers the opportunity for organic chemists to explore a surprisingly large variety of scientific avenues. It lends itself naturally to multidisciplinary research projects and provides the sophisticated tools with which the most complex of processes can be investigated. This Melvin Calvin Award lecture will keep to a broadly chronological theme and will give examples of how the remarkable versatility of the two heavy hydrogen isotopes has been utilised during collaborative studies in areas as varied as plant and insect biochemistry, drug metabolism and pharmacokinetics, structure determination, NMR spectroscopy, reaction mechanisms, molecular energetics and novel catalyst development. Few other careers can provide the opportunity to study such varied and fundamental subjects and still provide challenges that are as compelling and exciting some 4 decades later. Copyright © 2013 John Wiley & Sons, Ltd.

49 CFR 511.36 - Motions to compel discovery.

Code of Federal Regulations, 2010 CFR

2010-10-01

... inspection or production of documents, or otherwise compelling discovery. For purposes of this subsection, an... a motion pursuant to § 511.31(d). When making oral examinations, the discovering party shall...

Tool bending in New Caledonian crows

PubMed Central

Sugasawa, Shoko; van der Wal, Jessica E. M.; Klump, Barbara C.; St Clair, James J. H.

2016-01-01

‘Betty’ the New Caledonian crow astonished the world when she ‘spontaneously’ bent straight pieces of garden wire into hooked foraging tools. Recent field experiments have revealed that tool bending is part of the species' natural behavioural repertoire, providing important context for interpreting Betty's iconic wire-bending feat. More generally, this discovery provides a compelling illustration of how natural history observations can inform laboratory-based research into the cognitive capacities of non-human animals. PMID:27853622

The anatomy and art of writing a successful grant application: a practical step-by-step approach.

PubMed

Gholipour, Ali; Lee, Edward Y; Warfield, Simon K

2014-12-01

Writing a compelling grant application is a skill that is crucial to conducting high-quality and high-impact scientific research. A successful grant proposal provides the resources necessary to foster activity in an important area of investigation. A concise and practical overview of the anatomy and art of grant writing is provided in this article, along with citations to resources that are particularly useful for junior investigators.

24 CFR 180.540 - Motion to compel discovery.

Code of Federal Regulations, 2010 CFR

2010-04-01

... order compelling discovery in accordance with the request. The motion shall: (1) State the nature of the... secondary evidence concerning the information sought; (6) Striking any appropriate part of the pleadings or...

Testing and extending the group engagement model: linkages between social identity, procedural justice, economic outcomes, and extrarole behavior.

PubMed

Blader, Steven L; Tyler, Tom R

2009-03-01

Two field studies tested and extended the group engagement model (Tyler & Blader, 2000, Tyler & Blader, 2003) by examining the model with regard to employee extrarole behavior. Consistent with the group engagement model's predictions, results of these studies indicate that the social identities employees form around their work groups and their organizations are strongly related to whether employees engage in extrarole behaviors. Moreover, the studies demonstrated that social identity explains the impact of other factors that have previously been linked to extrarole behavior. In particular, the findings indicate that social identity mediates the effect of procedural justice judgments and economic outcomes on supervisor ratings of extrarole behavior. Overall, these studies provide compelling indication that social identity is an important determinant of behavior within work organizations and provide strong support for the application of the group engagement model in organizational settings. (c) 2009 APA, all rights reserved.

Evaluation of Wearable Haptic Systems for the Fingers in Augmented Reality Applications.

PubMed

Maisto, Maurizio; Pacchierotti, Claudio; Chinello, Francesco; Salvietti, Gionata; De Luca, Alessandro; Prattichizzo, Domenico

2017-01-01

Although Augmented Reality (AR) has been around for almost five decades, only recently we have witnessed AR systems and applications entering in our everyday life. Representative examples of this technological revolution are the smartphone games "Pokémon GO" and "Ingress" or the Google Translate real-time sign interpretation app. Even if AR applications are already quite compelling and widespread, users are still not able to physically interact with the computer-generated reality. In this respect, wearable haptics can provide the compelling illusion of touching the superimposed virtual objects without constraining the motion or the workspace of the user. In this paper, we present the experimental evaluation of two wearable haptic interfaces for the fingers in three AR scenarios, enrolling 38 participants. In the first experiment, subjects were requested to write on a virtual board using a real chalk. The haptic devices provided the interaction forces between the chalk and the board. In the second experiment, subjects were asked to pick and place virtual and real objects. The haptic devices provided the interaction forces due to the weight of the virtual objects. In the third experiment, subjects were asked to balance a virtual sphere on a real cardboard. The haptic devices provided the interaction forces due to the weight of the virtual sphere rolling on the cardboard. Providing haptic feedback through the considered wearable device significantly improved the performance of all the considered tasks. Moreover, subjects significantly preferred conditions providing wearable haptic feedback.

Molecular Mechanisms of Preeclampsia

PubMed Central

Hod, Tammy; Cerdeira, Ana Sofia; Karumanchi, S. Ananth

2015-01-01

Preeclampsia is a pregnancy-specific disease characterized by new onset hypertension and proteinuria after 20 wk of gestation. It is a leading cause of maternal and fetal morbidity and mortality worldwide. Exciting discoveries in the last decade have contributed to a better understanding of the molecular basis of this disease. Epidemiological, experimental, and therapeutic studies from several laboratories have provided compelling evidence that an antiangiogenic state owing to alterations in circulating angiogenic factors leads to preeclampsia. In this review, we highlight the role of key circulating antiangiogenic factors as pathogenic biomarkers and in the development of novel therapies for preeclampsia. PMID:26292986

Was monogamy a key step on the hominin road? Reevaluating the monogamy hypothesis in the evolution of cooperative breeding.

PubMed

Kramer, Karen L; Russell, Andrew F

2015-01-01

Because human mothers routinely rely on others to help raise their young, humans have been characterized as cooperative breeders.(1-9) Several large-scale phylogenetic analyses have presented compelling evidence that monogamy preceded the evolution of cooperative breeding in a wide variety of nonhuman animals.(10-14) These studies have suggested that monogamy provides a general rule (the monogamy hypothesis) for explaining evolutionary transitions to cooperative breeding.(15) Given the prevalence of cooperative breeding in contemporary human societies, we evaluate whether this suggests a monogamous hominin past. © 2015 Wiley Periodicals, Inc.

From Claude Bernard to the Batcave and Beyond: Using Batman as a Hook for Physiology Education

ERIC Educational Resources Information Center

Zehr, E. Paul

2011-01-01

Communicating physiology to the general public and popularizing science can be tremendously rewarding activities. Providing relevant and compelling points of linkage, however, between the scientific experiences and the interests of the general public can be challenging. One avenue for popularizing science is to link scientific concepts to images,…

Progress for Children: A Report Card on Adolescents. Number 10

ERIC Educational Resources Information Center

UNICEF, 2012

2012-01-01

Adolescence is a formative period during which children grow into their rightful place as full citizens and agents of change in their own lives and the lives of their societies. This publication provides an overview of the situation of adolescents, including of their vulnerabilities in critical areas. It makes a compelling case for increased…

Special Issue: Bridging the Diversity Divide--Globalization and Reciprocal Empowerment in Higher Education

ERIC Educational Resources Information Center

Chun, Edna; Evans, Alvin

2009-01-01

In this monograph, the authors focus on concrete approaches and tools that will assist educational leaders and educators in the creation of a genuinely inclusive campus culture. The first chapter, "The Changing Landscape and the Compelling Need for Diversity," provides an overview of forces that have historically inhibited the inclusion of women…

Annual Research Review: Epigenetic Mechanisms and Environmental Shaping of the Brain during Sensitive Periods of Development

ERIC Educational Resources Information Center

Roth, Tania L.; Sweatt, J. David

2011-01-01

Experiences during early development profoundly affect development of the central nervous system (CNS) to impart either risk for or resilience to later psychopathology. Work in the developmental neuroscience field is providing compelling data that epigenetic marking of the genome may underlie aspects of this process. Experiments in rodents…

Field Trip to the Moon. Educator's Guide. EG-2007-09-120-MSFC

ERIC Educational Resources Information Center

National Aeronautics and Space Administration (NASA), 2007

2007-01-01

The Field Trip to the Moon program uses an inquiry-based learning approach that fosters team building and introduces students to careers in science and engineering. The program components include a DVD and classroom investigations. The compelling DVD (not included here) provides essential information about Earth and the Moon. The hands-on…

A Theory on Becoming an Entrepreneurial Leader: A Student's Developmental Journey to a Creation-Driven Mindset

ERIC Educational Resources Information Center

Newman, Elizabeth Betsy Lavelle

2013-01-01

There is a compelling need to educate more entrepreneurial leaders of the 21st century with new and innovative approaches; and, higher education is poised to respond. Entrepreneurship plays a critical role in fueling local, national, and global economies and in providing prosperous livelihoods to diverse people, communities, and societies. And…

Alternate Reality Games as Learning Environments for Student Induction

ERIC Educational Resources Information Center

Whitton, Nicola; Jones, Rosie; Wilson, Scott; Whitton, Peter

2014-01-01

Alternate reality games (ARGs) are a relatively new form of collaborative game that make use of both the virtual and real worlds to engage players in a series of challenges within a compelling narrative. The Alternate Reality Games for Orientation, Socialisation and Induction (ARGOSI) project aimed to use this game format to provide an alternative…

Perspectives on Outcome Based Evaluation for Libraries and Museums.

ERIC Educational Resources Information Center

Institute of Museum and Library Services, Washington, DC.

If museums and libraries are to compete for both public and private funds in an accountability-driven environment, they must develop evaluation practices that provide the most compelling picture of the impact of their services. The two essays in this document present clear arguments for the adoption of a specific approach to evaluation known as…

U.S. v. "Providence Journal": The First Amendment and the Constitutionality of Enforcing Unconstitutional Orders.

ERIC Educational Resources Information Center

Labunski, Richard

Serious constitutional problems arise when the contempt power of judges clashes with other compelling interests such as those of the First Amendment. The "collateral bar" rule--which requires that court orders, even those later determined to be unconstitutional, must be complied with until amended or vacated--in effect, calls for…

The Cost of High-Quality Pre-School Education in New Jersey

ERIC Educational Resources Information Center

Belfield, Clive; Schwartz, Heather

2007-01-01

This report calculates the full cost of providing well-planned, high quality pre-school for children in New Jersey, as required under "Abbott vs. Burke" (153 NJ 480 1998). The evidence on how high-quality pre-school improves the academic performance of children is compelling. After a rapid expansion over the last decade, many children in…

Guidelines for Writing Charter School Accountability Plans

ERIC Educational Resources Information Center

Massachusetts Department of Education, 2004

2004-01-01

A charter school creates an Accountability Plan to articulate to the community and the state what goals the school will use to measure its success. These "Guidelines" are intended to give schools guidance on the type of data that provide compelling evidence, the desirable structure for goals and objectives, and how to most clearly present results.…

45 CFR 2507.5 - How does the Corporation process requests for records?

Code of Federal Regulations, 2013 CFR

2013-10-01

... compelled to create new records or do statistical computations. For example, the Corporation is not required... feasible way to respond to a request. The Corporation is not required to perform any research for the... duplicating all of them. For example, if it requires less time and expense to provide a computer record as a...

75 FR 69130 - Proposed Extension of Information Collection Request Submitted for Public Comment; Prohibited...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-10

.... Description: Without the relief provided by this exemption, an open-end mutual fund would be unable to sell... investment advisor for the mutual fund. As a result, plans would be compelled to liquidate their existing... disclosure requirements. The first requires at the time of the purchase or sale of such mutual fund shares...

Here Comes the (Daughter of the) Bride: Parental Weddings in Two Contemporary Girls' Series Books

ERIC Educational Resources Information Center

Sweeney, Meghan M.

2009-01-01

This article examines the way that weddings are portrayed in contemporary series fiction for girls, in particular Ann M. Martin's "The Baby-sitters Club" and Phyllis Reynolds Naylor's "Alice" books. It argues that, while weddings in these novels offer the protagonists supporting roles in compelling family dramas, they also provide few…

Outdoor Adventure Education in East Asia: Interpreting Data from Outward Bound Hong Kong

ERIC Educational Resources Information Center

Sibthorp, Jim; Funnell, Aaron; Riley, Mike; Chan, Bacon; Meerts-Brandsma, Lisa

2018-01-01

Outdoor adventure education (OAE) is philosophically rooted in Western values, yet it has been implemented in non-Western cultures, such as East Asia. This paper examines how OAE functions in East Asia, through data from Hong Kong. Although some cultural differences are clear, there is no compelling evidence that OAE cannot provide benefits in…

Disallowing Recommendations for Practice and Policy: A Proposal that Is Both Too Much and Too Little

ERIC Educational Resources Information Center

Harris, Karen R.

2013-01-01

Robinson et al. ("Educ Psychol Rev" 25(2):291-302, 2013) offer a thoughtful and powerful argument for a policy change for primary educational research journals. This policy change would "disallow recommendations for practice" (p. 10) in primary educational research journals. They provided compelling examples of works in which…

Governing Global Health - Challenge, Response, Innovation Schrecker Ted Kirton John J Cooper Andrew F Governing Global Health - Challenge, Response, Innovation 320 Ashgate 9780754648734 0754648737.

PubMed

2007-10-24

This excellent book provides a comprehensive and analytical overview of the socio-political and economic factors that contribute to an understanding of global health governance. The opening chapter outlines compelling arguments for why such an understanding should be everyone's business.

E-Learning for SMEs: Competition and Dimensions of Perceived Value

ERIC Educational Resources Information Center

Roffe, Ian

2004-01-01

E-learning is such an attractive opportunity for training providers to reconfigure delivery and support that it presents compelling reasons to engage with the practice. A broad range of provision is therefore available for every type of market segment, including small firms. Sustaining a competitive advantage from a host of offers is a practical…

Exuberance and Despair

ERIC Educational Resources Information Center

Blount, Jackie

2013-01-01

As a historian of education, what excites you and compels you to keep doing scholarly work? If mortality were not an issue, how might you find your continued place in the field among ideas and sources that are dauntingly and increasingly vast? What is the work you most want to do? Jackie Blount provides her response herein: She would want to…

Pedagogy for the Connected Science Classroom: Computer Supported Collaborative Science and the Next Generation Science Standards

ERIC Educational Resources Information Center

Foley, Brian J.; Reveles, John M.

2014-01-01

The prevalence of computers in the classroom is compelling teachers to develop new instructional skills. This paper provides a theoretical perspective on an innovative pedagogical approach to science teaching that takes advantage of technology to create a connected classroom. In the connected classroom, students collaborate and share ideas in…

Classic Teenplots: A Booktalk Guide to Use with Readers Ages 12-18

ERIC Educational Resources Information Center

Gillespie, John T.; Naden, Corinne

2006-01-01

This resource provides tools needed to create compelling booktalks featuring outstanding young adult novels that are mainstays in library collections. For each of the 100 titles selected, there is background information on the book and the author, a list of principal characters, a detailed plot summary, critical comment and notes on suitability,…

Whose Compelling Interest? The Ending of Desegregation and the Affirming of Racial Inequality in Education

ERIC Educational Resources Information Center

Donnor, Jamel K.

2012-01-01

This article provides a critical race analysis of the U.S. Supreme Court's decision to declare voluntary public school integration unconstitutional in Parents v. Seattle School District No.1. The author contends that the high Court used a perpetrator perspective of racial discrimination to privilege the self-interests of white families over…

Pollutional haze as a potential cause of lung cancer.

PubMed

Shi, Xuefei; Liu, Hongbing; Song, Yong

2015-10-01

Along with fast economic growth over the past few decades, the world is faced with cumulatively serious environmental pollution and now is paying increased attention to pollutional haze. In the last few years, multiple epidemiological studies and animal models have provided compelling evidences that inhalation of pollutional haze could be linked to several adverse health effects. Since the respiratory tract is the crucial passageway of entry of pollutional haze, the lung is the main affected organ. Therefore, here, we reviewed some of the important information around long-term exposure to pollutional haze and lung cancer, as well as highlight important roles of pollutional haze in human lung carcinogenesis, providing evidence for pollutional haze acting as another risk factor for lung cancer.

Microbial Fuel Cell Possibilities on American Indian Tribal Lands

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cameron, Kimberlynn

The purpose of this paper is to present a brief background of tribal reservations, the process of how Microbial Fuel Cells (MFCs) work, and the potential benefits of using MFCs on tribal reservations to convert waste water to energy as a means to sustainably generate electricity. There have been no known studies conducted on tribal lands that would be able to add to the estimated percentage of all renewable energy resources identified. Not only does MFC technology provide a compelling, innovative solution, it could also address better management of wastewater, using it as a form of energy generation. Using wastewatermore » for clean energy generation could provide a viable addition to community infrastructure systems improvements.« less

The PTSD Practitioner Registry: An Innovative Tracking, Dissemination, and Support Tool for Providers in Military and Nonmilitary Settings

DTIC Science & Technology

2015-10-01

stress and burnout will also be discussed. GOAL: If successful, we plan to maintain and expand the PTSD Practitioner Registry as a novel mechanism...a compelling priority for clinicians working with active-duty Warriors and Veterans with Post Traumatic Stress Disorder (PTSD). The PTSD...Warriors and Veterans with PTSD as well as their families. It will also provide a way of monitoring the levels of burnout among PTSD treatment

The need to know caregiver perspectives toward using smart home technology.

PubMed

Giger, Jarod T; Markward, Martha

2011-01-01

This article reviews the literature on adults with serious mental illness, their caregivers, and smart home technology. The article provides compelling evidence for social workers to undertake research aimed at investigating caregivers' perceptions toward using smart home technology for care of adult family members or friends with a serious mental illness. Empirical support for using smart home technologies with adults with serious mental illness is provided, and recommendations for future social work research are offered.

A curious fact: Photic sneeze reflex. Autosomical dominant compelling helio-ophthalmic outburst syndrome.

PubMed

Sevillano, C; Parafita-Fernández, A; Rodriguez-Lopez, V; Sampil, M; Moraña, N; Viso, E; Cores, F J

2016-07-01

To assess ocular involvement in the pathophysiology of autosomal dominant compelling helio-ophthalmic outburst syndrome (ACHOOs). An interview was conducted with a Caucasian family that showed clinical features of ACHOOs. Twelve of them had photic reflex and were recruited. A complete eye evaluation was made. A dominant autosomal inheritance with mild penetrance was demonstrated, with 67% of the studied subjects showing some degree of prominent corneal nerves. No other eye changes were found. Prominent corneal nerves may be associated with ACHOOs. The other eye structures studied do not seem to play a role in ACHOOs. Further studies are needed to understand the physiology of the ACHOOs. Copyright © 2016 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

Hydrodynamic Simulations of Protoplanetary Disks with GIZMO

NASA Astrophysics Data System (ADS)

Rice, Malena; Laughlin, Greg

2018-01-01

Over the past several decades, the field of computational fluid dynamics has rapidly advanced as the range of available numerical algorithms and computationally feasible physical problems has expanded. The development of modern numerical solvers has provided a compelling opportunity to reconsider previously obtained results in search for yet undiscovered effects that may be revealed through longer integration times and more precise numerical approaches. In this study, we compare the results of past hydrodynamic disk simulations with those obtained from modern analytical resources. We focus our study on the GIZMO code (Hopkins 2015), which uses meshless methods to solve the homogeneous Euler equations of hydrodynamics while eliminating problems arising as a result of advection between grid cells. By comparing modern simulations with prior results, we hope to provide an improved understanding of the impact of fluid mechanics upon the evolution of protoplanetary disks.

Baseline studies in the Elwha River ecosystem prior to dam removal: Introduction to the special issue

USGS Publications Warehouse

Duda, Jeffrey J.; Freilich, Jerry; Schreiner, Edward G.

2008-01-01

The planned removal of two dams that have been in place for over 95 years on the Elwha River provides a unique opportunity to study dam removal effects. Among the largest dams ever considered for removal, this project is compelling because 83% of the watershed lies undisturbed in Olympic National Park. Eighteen million cubic meters of sediment have accumulated in and will be released from the reservoirs, and there is potential for rehabilitating depressed Pacific salmon runs. Researchers from academia, non-profit organizations, federal and state governments, and the Lower Elwha Klallam Tribe are currently assessing baseline ecological conditions of the Elwha River as part of dam removal studies. We introduce dam removal topics, provide a brief history of the dams, and summarize the ecology of the Elwha River basin as an introduction to a special issue devoted to research in the watershed.

4 CFR 28.43 - Compelling discovery.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Compelling discovery. 28.43 Section 28.43 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL APPEALS BOARD; PROCEDURES APPLICABLE TO CLAIMS CONCERNING EMPLOYMENT PRACTICES AT THE GOVERNMENT ACCOUNTABILITY OFFICE...

Hormonally active phytochemicals and vertebrate evolution.

PubMed

Lambert, Max R; Edwards, Thea M

2017-06-01

Living plants produce a diversity of chemicals that share structural and functional properties with vertebrate hormones. Wildlife species interact with these chemicals either through consumption of plant materials or aquatic exposure. Accumulating evidence shows that exposure to these hormonally active phytochemicals (HAPs) often has consequences for behavior, physiology, and fecundity. These fitness effects suggest there is potential for an evolutionary response by vertebrates to HAPs. Here, we explore the toxicological HAP-vertebrate relationship in an evolutionary framework and discuss the potential for vertebrates to adapt to or even co-opt the effects of plant-derived chemicals that influence fitness. We lay out several hypotheses about HAPs and provide a path forward to test whether plant-derived chemicals influence vertebrate reproduction and evolution. Studies of phytochemicals with direct impacts on vertebrate reproduction provide an obvious and compelling system for studying evolutionary toxicology. Furthermore, an understanding of whether animal populations evolve in response to HAPs could provide insightful context for the study of rapid evolution and how animals cope with chemical agents in the environment.

Neural mechanisms of oculomotor abnormalities in the infantile strabismus syndrome.

PubMed

Walton, Mark M G; Pallus, Adam; Fleuriet, Jérome; Mustari, Michael J; Tarczy-Hornoch, Kristina

2017-07-01

Infantile strabismus is characterized by numerous visual and oculomotor abnormalities. Recently nonhuman primate models of infantile strabismus have been established, with characteristics that closely match those observed in human patients. This has made it possible to study the neural basis for visual and oculomotor symptoms in infantile strabismus. In this review, we consider the available evidence for neural abnormalities in structures related to oculomotor pathways ranging from visual cortex to oculomotor nuclei. These studies provide compelling evidence that a disturbance of binocular vision during a sensitive period early in life, whatever the cause, results in a cascade of abnormalities through numerous brain areas involved in visual functions and eye movements. Copyright © 2017 the American Physiological Society.

Revealing W51C as a Cosmic-Ray source using Fermi-LAT data

DOE PAGES

Jogler, T.; Funk, S.

2016-01-10

Here, supernova remnants (SNRs) are commonly believed to be the primary sources of Galactic cosmic rays. Despite intensive study of the non-thermal emission of many SNRs the identification of the accelerated particle type relies heavily on assumptions of ambient-medium parameters that are only loosely constrained. Compelling evidence of hadronic acceleration can be provided by detecting a strong roll-off in the secondary γ-ray spectrum below themore » $${\\pi }^{0}$$ production threshold energy of about 135 MeV, the so called "pion bump." Here we use five years of Fermi-Large Area Telescope data to study the spectrum above 60 MeV of the middle-aged SNR W51C. A clear break in the power-law γ-ray spectrum at $${E}_{{\\rm{break}}}=290\\pm 20\\;{\\rm{MeV}}$$ is detected with $$9\\sigma $$ significance and we show that this break is most likely associated with the energy production threshold of $${\\pi }^{0}$$mesons. A high-energy break in the γ-ray spectrum at about 2.7 GeV is found with $$7.5\\sigma $$ significance. The spectral index at energies beyond this second break is $${{\\rm{\\Gamma }}}_{2}={2.52}_{-0.07}^{+0.06}$$ and closely matches the spectral index derived by the MAGIC Collaboration above 75 GeV. Therefore our analysis provides strong evidence to explain the γ-ray spectrum of W51C by a single particle population of protons with a momentum spectrum best described by a broken power law with break momentum $${p}_{{\\rm{break}}}\\sim 80\\;{\\rm{G}}{\\rm{e}}{\\rm{V}}/c.$$ W51C is the third middle-aged SNR that displays compelling evidence for cosmic-ray acceleration and thus strengthens the case of SNRs as the main source of Galactic cosmic rays.« less

Iran Sanctions

DTIC Science & Technology

2010-06-23

Act) authorizes sanctions on foreign persons (individuals or corporations , not countries or governments ) that are determined by the Administration to...sanctions, particularly those targeting Iran’s energy sector, which provides about 80% of government revenues, can reduce Iran’s ability to support its WMD...foreign firm’s business opportunities in the United States. ISA does not, and probably could not practically, compel any foreign government to take action

Maniac Talk - Dr. Marshall Shepherd

NASA Image and Video Library

2015-07-14

Marshall Shepherd Maniac Lecture, July 14, 2015 Dr. Marshall Shepherd, professor, University of Georgia, also the host of Sunday's talk show Weather Geeks, presented a Maniac lecture entitled "Zombies, Sports, and Cola: Implications for Communicating Weather and Climate." Believe it or not, Dr. Shepherd ties zombies, sports, and cola together to provide a compelling look at how we communicate (miscommunicate) weather and climate.

Storytelling at Its Best: Using the StartUp Podcast in the Classroom

ERIC Educational Resources Information Center

Teckchandani, Atul; Obstfeld, David

2017-01-01

This article discusses the virtues of using podcasts in the classroom by focusing on the pedagogical merits of one podcast: StartUp. The StartUp podcast provides a compelling first-person account of the entrepreneurial journey, as told by an award-winning radio journalist. Episodes from the podcast can be used to engage students and improve their…

Could Caldecott Have Won the Caldecott? Victorian Views on Selection and Evaluation.

ERIC Educational Resources Information Center

Lundin, Anne

1998-01-01

Provides a close description of the ways that Randolph Caldecott's work continues to compel admiration to show how classic texts that are selected and evaluated in the marketplace are the product of historical contingencies. Suggests that the choice of Caldecott as the name for the big prize in children's book illustration was and is fitting. (RS)

Spark Ignition of Combustible Vapor in a Plastic Bottle as a Demonstration of Rocket Propulsion

ERIC Educational Resources Information Center

Mattox, J. R.

2017-01-01

I report an innovation that provides a compelling demonstration of rocket propulsion, appropriate for students of physics and other physical sciences. An electrical spark is initiated from a distance to cause the deflagration of a combustible vapor mixed with air in a lightweight plastic bottle that is consequently propelled as a rocket by the…

Personalised and Self Regulated Learning in the Web 2.0 Era: International Exemplars of Innovative Pedagogy Using Social Software

ERIC Educational Resources Information Center

McLoughlin, Catherine; Lee, Mark J. W.

2010-01-01

Research findings in recent years provide compelling evidence of the importance of encouraging student control over the learning process as a whole. The socially based tools and technologies of the Web 2.0 movement are capable of supporting informal conversation, reflexive dialogue and collaborative content generation, enabling access to a wide…

Complexity and Targeting in Federal Student Aid: A Quantitative Analysis. NBER Working Paper No. 13801

ERIC Educational Resources Information Center

Dynarski, Susan; Scott-Clayton, Judith E.

2008-01-01

A growing body of empirical evidence shows that some financial aid programs increase college enrollment. Puzzlingly, there is little compelling evidence that Pell Grants and Stafford Loans, the primary federal student aid programs, are effective in achieving this goal. In this paper, we provide an in-depth review of this evidence, which taken as a…

Inelastic dark matter in light of DAMA/LIBRA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, Spencer; Weiner, Neal; Kribs, Graham D.

2009-02-15

Inelastic dark matter, in which weakly interacting massive particle (WIMP)-nucleus scatterings occur through a transition to an excited WIMP state {approx}100 keV above the ground state, provides a compelling explanation of the DAMA annual modulation signal. We demonstrate that the relative sensitivities of various dark matter direct detection experiments are modified such that the DAMA annual modulation signal can be reconciled with the absence of a reported signal at CDMS-Soudan, XENON10, ZEPLIN, CRESST, and KIMS for inelastic WIMPs with masses O(100 GeV). We review the status of these experiments, and make predictions for upcoming ones. In particular, we note thatmore » inelastic dark matter leads to highly suppressed signals at low energy, with most events typically occurring between 20 and 45 keV (unquenched) at xenon and iodine experiments, and generally no events at low ({approx}10 keV) energies. Suppressing the background in this high-energy region is essential to testing this scenario. The recent CRESST data suggest seven observed tungsten events, which is consistent with expectations from this model. If the tungsten signal persists at future CRESST runs, it would provide compelling evidence for inelastic dark matter, while its absence should exclude it.« less

The PTSD Practitioner Registry: An Innovative Tracking, Dissemination, and Support Tool for Providers in Military and Nonmilitary Settings

DTIC Science & Technology

2015-10-01

practice-related stress and burnout will also be discussed. GOAL: If successful, we plan to maintain and expand the PTSD Practitioner Registry as a...related disorders is a compelling priority for clinicians working with active-duty Warriors and Veterans with Post Traumatic Stress Disorder (PTSD). The...quality of care for Warriors and Veterans with PTSD as well as their families. It will also provide a way of monitoring the levels of burnout among PTSD

The PTSD Practitioner Registry: An Innovative Tracking, Dissemination, and Support Tool for Providers in Military and Nonmilitary settings

DTIC Science & Technology

2017-10-01

the registry as well as pre- test the proposed registry survey. In Phase II, an RCT is being conducted to evaluate the impact of registry...disorders is a compelling priority for clinicians working with active-duty Warriors and Veterans with Post Traumatic Stress Disorder (PTSD). The PTSD...4. 2) Develop and pre- test interview modules (10/14-11/14) 100% complete on 03/15 3) Recruit providers for interview assessments (10/14-03/15)100

40 CFR 1610.4 - Deposition Transcripts.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Deposition Transcripts. 1610.4 Section... INVESTIGATIONS § 1610.4 Deposition Transcripts. (a) Transcripts of depositions of witnesses compelled by subpoena... by the person conducting the deposition. (b) Such a witness, after completing the compelled testimony...

40 CFR 1610.4 - Deposition Transcripts.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Deposition Transcripts. 1610.4 Section... INVESTIGATIONS § 1610.4 Deposition Transcripts. (a) Transcripts of depositions of witnesses compelled by subpoena... by the person conducting the deposition. (b) Such a witness, after completing the compelled testimony...

Compelling Diversities, Educational Intersections: Policy, Practice, Parity

ERIC Educational Resources Information Center

Taylor, Yvette

2013-01-01

The ninth international Gender and Education Association Conference "Compelling Diversities, Educational Intersections" hosted by the Weeks Centre for Social and Policy Research, London South Bank University engages with key debates surrounding the interplay between dynamics of education, work, employment and society in the context of…

Screen Violence and Youth Behavior.

PubMed

Anderson, Craig A; Bushman, Brad J; Bartholow, Bruce D; Cantor, Joanne; Christakis, Dimitri; Coyne, Sarah M; Donnerstein, Edward; Brockmyer, Jeanne Funk; Gentile, Douglas A; Green, C Shawn; Huesmann, Rowell; Hummer, Tom; Krahé, Barbara; Strasburger, Victor C; Warburton, Wayne; Wilson, Barbara J; Ybarra, Michele

2017-11-01

Violence in screen entertainment media (ie, television, film, video games, and the Internet), defined as depictions of characters (or players) trying to physically harm other characters (or players), is ubiquitous. The Workgroup on Media Violence and Violent Video Games reviewed numerous meta-analyses and other relevant research from the past 60 years, with an emphasis on violent video game research. Consistent with every major science organization review, the Workgroup found compelling evidence of short-term harmful effects, as well as evidence of long-term harmful effects. The vast majority of laboratory-based experimental studies have revealed that violent media exposure causes increased aggressive thoughts, angry feelings, physiologic arousal, hostile appraisals, aggressive behavior, and desensitization to violence and decreases prosocial behavior (eg, helping others) and empathy. Still, to more fully understand the potential for long-term harm from media violence exposure, the field is greatly in need of additional large-sample, high-quality, longitudinal studies that include validated measures of media violence exposure and measures of other known violence risk factors. Also, although several high-quality media violence intervention studies have been conducted, larger-scale studies with more comprehensive and longer-term assessments are needed to fully understand long-term effects and to inform the development of tools that will help to reduce problems associated with aggression and violence. The evidence that violent screen media constitutes a causal risk factor for increased aggression is compelling. Modern social-cognitive theories of social behavior provide useful frameworks for understanding how and why these effects occur. Copyright © 2017 by the American Academy of Pediatrics.

Conclusions, synthesis, and future directions: understanding sources of population change

USGS Publications Warehouse

Esler, Daniel N.; Flint, Paul L.; Derksen, Dirk V.; Savard, Jean-Pierre L.; Eadie, John M.

2015-01-01

The material in this volume reflects the burgeoning interest in sea ducks, both as study species with compelling and unique ecological attributes and as taxa of conservation concern. In this review, we provide perspective on the current state of sea duck knowledge by highlighting key findings in the preceding chapters that are of particular value for understanding or influencing population change. We also introduce a conceptual model that characterizes links among topics covered by individual chapters and places them in the context of demographic responses. Finally, we offer recommendations for areas of future research that we suggest will have importance for understanding and managing sea duck population dynamics.

The age 60 rule.

PubMed

2004-08-01

The impetus for amending the Age 60 Rule compels the review of recent scientific literature pertinent to pilot age and performance. The Rule has been the subject of extensive debate among policymakers and the aviation community. The aviation medical community is in a position to continue research and discussion that may provide additional evidence for the development of future policy decisions. Those addressing the future of the Age 60 Rule may benefit from understanding the nature and limitations of these studies, whether their outcomes are conclusive or not. Hopefully, some measure of guidance may be achieved as they address pilot age limits and related safety, economic, and operational issues of the aviation industry.

Hypnotic suggestion: opportunities for cognitive neuroscience.

PubMed

Oakley, David A; Halligan, Peter W

2013-08-01

Hypnosis uses the powerful effects of attention and suggestion to produce, modify and enhance a broad range of subjectively compelling experiences and behaviours. For more than a century, hypnotic suggestion has been used successfully as an adjunctive procedure to treat a wide range of clinical conditions. More recently, hypnosis has attracted a growing interest from a cognitive neuroscience perspective. Recent studies using hypnotic suggestion show how manipulating subjective awareness in the laboratory can provide insights into brain mechanisms involved in attention, motor control, pain perception, beliefs and volition. Moreover, they indicate that hypnotic suggestion can create informative analogues of clinical conditions that may be useful for understanding these conditions and their treatments.

Molecular Mechanisms of Preeclampsia.

PubMed

Hod, Tammy; Cerdeira, Ana Sofia; Karumanchi, S Ananth

2015-08-20

Preeclampsia is a pregnancy-specific disease characterized by new onset hypertension and proteinuria after 20 wk of gestation. It is a leading cause of maternal and fetal morbidity and mortality worldwide. Exciting discoveries in the last decade have contributed to a better understanding of the molecular basis of this disease. Epidemiological, experimental, and therapeutic studies from several laboratories have provided compelling evidence that an antiangiogenic state owing to alterations in circulating angiogenic factors leads to preeclampsia. In this review, we highlight the role of key circulating antiangiogenic factors as pathogenic biomarkers and in the development of novel therapies for preeclampsia. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

Raw food diets in companion animals: A critical review

PubMed Central

Schlesinger, Daniel P.; Joffe, Daniel J.

2011-01-01

Feeding of raw meat-based diets to pets has become an increasingly popular trend amongst pet owners. Owners, who desire to provide the best for their pets, seek veterinary opinions about food options. This paper reviews and applies standards of evidence-based medicine to grade the available scientific literature that addresses the nutritional benefits or risks, infectious disease risks, and public health implications of raw, meat-based pet diets. Although there is a lack of large cohort studies to evaluate risk or benefit of raw meat diets fed to pets, there is enough evidence to compel veterinarians to discuss human health implications of these diets with owners. PMID:21461207

Complexity and conflicts of interest statements: a case-study of emails exchanged between Coca-Cola and the principal investigators of the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE).

PubMed

Stuckler, David; Ruskin, Gary; McKee, Martin

2018-02-01

Statements on conflicts of interest provide important information for readers of scientific papers. There is now compelling evidence from several fields that papers reporting funding from organizations that have an interest in the results often generate different findings from those that do not report such funding. We describe the findings of an analysis of correspondence between representatives of a major soft drinks company and scientists researching childhood obesity. Although the studies report no influence by the funder, the correspondence describes detailed exchanges on the study design, presentation of results and acknowledgement of funding. This raises important questions about the meaning of standard statements on conflicts of interest.

Sperm Proteome: What Is on the Horizon?

PubMed

Mohanty, Gayatri; Swain, Nirlipta; Samanta, Luna

2015-06-01

As the mammalian spermatozoa transcends from the testis to the end of the epididymal tubule, the functionally incompetent spermatozoa acquires its fertilizing capability. Molecular changes in the spermatozoa at the posttesticular level concern qualitative and quantitative modifications of proteins along with their sugar moieties and membranous lipids mostly associated with motility, egg binding, and penetration processes. Proteomic studies have identified numerous sperm-specific proteins, and recent reports have provided a further understanding of their function with respect to male fertility. High-throughput techniques such as mass spectrometry have shown drastic potential for the identification and study of sperm proteins. In fact, compelling evidence has provided that proteins are critically important in cellular remodeling event and that aberrant expression is associated with pronounced defects in sperm function. This review highlights the posttesticular functional transformation in the epididymis and female reproductive tract with due emphasis on proteomics. © The Author(s) 2014.

Primer Part 1-The building blocks of epilepsy genetics.

PubMed

Helbig, Ingo; Heinzen, Erin L; Mefford, Heather C

2016-06-01

This is the first of a two-part primer on the genetics of the epilepsies within the Genetic Literacy Series of the Genetics Commission of the International League Against Epilepsy. In Part 1, we cover the foundations of epilepsy genetics including genetic epidemiology and the range of genetic variants that can affect the risk for developing epilepsy. We discuss various epidemiologic study designs that have been applied to the genetics of the epilepsies including population studies, which provide compelling evidence for a strong genetic contribution in many epilepsies. We discuss genetic risk factors varying in size, frequency, inheritance pattern, effect size, and phenotypic specificity, and provide examples of how genetic risk factors within the various categories increase the risk for epilepsy. We end by highlighting trends in epilepsy genetics including the increasing use of massive parallel sequencing technologies. Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.

Quantifying Reinforcement Value and Demand for Psychoactive Substances in Humans

PubMed Central

Heinz, Adrienne J.; Lilje, Todd C.; Kassel, Jon D.; de Wit, Harriet

2013-01-01

Behavioral economics is an emerging cross-disciplinary field that is providing an exciting new contextual framework for researchers to study addictive processes. New initiatives to study addiction under a behavioral economic rubric have yielded variable terminology and differing methods and theoretical approaches that are consistent with the multidimensional nature of addiction. The present article is intended to provide an integrative overview of the behavioral economic nomenclature and to describe relevant theoretical models, principles and concepts. Additionally, we present measures derived from behavioral economic theories that quantify demand for substances and assess decision making processes surrounding substance use. The sensitivity of these measures to different contextual elements (e.g., drug use status, acute drug effects, deprivation) is also addressed. The review concludes with discussion of the validity of these approaches and their potential for clinical application and highlights areas that warrant further research. Overall, behavioral economics offers a compelling framework to help explicate complex addictive processes and it is likely to provide a translational platform for clinical intervention. PMID:23062106

FDA-Required Tobacco Product Inserts & Onserts–and the First Amendment.

PubMed

Lindblom, Eric N; Berman, Micah L; Thrasher, James F

In 2012, a federal court of appeals struck down an FDA rule requiring graphic health warnings on cigarettes as violating First Amendment commercial speech protections. Tobacco product inserts and onserts can more readily avoid First Amendment constraints while delivering more extensive information to tobacco users, and can work effectively to support and encourage smoking cessation. This paper examines FDA’s authority to require effective inserts and onserts and shows how FDA could design and support them to avoid First Amendment problems. Through this process, the paper offers helpful insights regarding how key Tobacco Control Act provisions can and should be interpreted and applied to follow and promote the statute’s purposes and objectives. The paper’s rigorous analysis of existing First Amendment case law relating to compelled commercial speech also provides useful guidance for any government efforts either to compel product disclosures or to require government messaging in or on commercial products or their advertising, whether done for remedial, purely informational, or behavior modification purposes.

Cross-Linguistic Differences in the Neural Representation of Human Language: Evidence from Users of Signed Languages

PubMed Central

Corina, David P.; Lawyer, Laurel A.; Cates, Deborah

2013-01-01

Studies of deaf individuals who are users of signed languages have provided profound insight into the neural representation of human language. Case studies of deaf signers who have incurred left- and right-hemisphere damage have shown that left-hemisphere resources are a necessary component of sign language processing. These data suggest that, despite frank differences in the input and output modality of language, core left perisylvian regions universally serve linguistic function. Neuroimaging studies of deaf signers have generally provided support for this claim. However, more fine-tuned studies of linguistic processing in deaf signers are beginning to show evidence of important differences in the representation of signed and spoken languages. In this paper, we provide a critical review of this literature and present compelling evidence for language-specific cortical representations in deaf signers. These data lend support to the claim that the neural representation of language may show substantive cross-linguistic differences. We discuss the theoretical implications of these findings with respect to an emerging understanding of the neurobiology of language. PMID:23293624

Joint Force Quarterly. Number 5, Summer 1994

DTIC Science & Technology

1994-07-01

terms of a matrix and have set it up to achieve things that matrix organizations facilitate. Matrices compel interaction across organizations; they...provide more joint, synergistic solutions to military problems. One primary result of this interaction between the assess- ment process and JROC is the...the Contingency Tactical Air Control Auto- mated Planning System (CTAPS) are both single-host computer sys- tems that do not support interactive data

The Political Control of the Soviet Armed Forces.

DTIC Science & Technology

1988-04-05

training aids. 9In sum, the MPA is 6 responsible for providing coordination and standardization for the political socialization in the Soviet military...compelling nationalist loyalties and to instill approved Socialist values in soldiers of the non- lavic minorities. Along with this political ... socialization the political officer will 21 conduct language classes for those minorities with low levels of Russian fluency. In summary, the large number of

Beyond economic games: a mutualistic approach to the rest of moral life.

PubMed

Graham, Jesse

2013-02-01

Mutualism provides a compelling account of the fairness intuitions on display in economic games. However, it is not yet clear how well the approach holds up as an explanation of all human morality. The theory needs to be tested outside the methodological neighborhood it was born in; such testing has the potential to greatly improve our understanding of morality in general.

Caring Enough To Lead: How Reflective Thought Leads to Moral Leadership. Second Edition.

ERIC Educational Resources Information Center

Pellicer, Leonard O.

This book examines what it means to be a leader. It is intended not only for education leaders but also for anyone who feels compelled to provide effective leadership. The content is based on the author's more than 30 years of experience as a professional educator. Each chapter illustrates a component of leadership through a series of questions,…

Iran Sanctions

DTIC Science & Technology

2010-07-12

particularly those targeting Iran’s energy sector that provides about 80% of government revenues, might reduce Iran’s ability to support its WMD and...such as Hizbollah, Hamas, and Palestine Islamic Jihad. Iran’s petroleum sector generates about 20% of Iran’s GDP, and 80% of its government revenue...probably could not practically, compel any foreign government to take action against one of its firms. Amendments added by P.L. 111-195, the

Prevention: a key component to saving lives and money.

PubMed

Brown, Steve

2009-03-01

It's no mystery that one of the chief culprits to our current economic crisis is skyrocketing costs of providing health care, particularly to our nation's growing baby boom population. This makes the case all the more compelling to practice as much preventative care as possible to avoid a myriad of conditions that could lead to lengthy and costly hospital stays, and potentially even death.

Exposure to School and Community Based Prevention Programs and Reductions in Cigarette Smoking among Adolescents in the United States, 2000-08

ERIC Educational Resources Information Center

Chen, Xinguang; Ren, Yuanjing; Lin, Feng; MacDonell, Karen; Jiang, Yifan

2012-01-01

Smoking remains prevalent among US youth despite decades of antismoking efforts. Effects from exposure to prevention programs at national level may provide informative and compelling data supporting better planning and strategy for tobacco control. A national representative sample of youth 12-17 years of age from the National Survey on Drug Use…

Using Rich Context and Data Exploration to Improve Engagement with Climate Data and Data Literacy: Bringing a Field Station into the College Classroom

ERIC Educational Resources Information Center

Ellwein, Amy L.; Hartley, Laurel M.; Donovan, Sam; Billick, Ian

2014-01-01

Authentic scientific data, when richly contextualized, can provide the basis for compelling learning experiences. Many undergraduate students either do not have access to primary data, or if they do, the data are so abstract that student engagement is limited. Here, we describe contextual information and data-rich, student-centered activities we…

Streamlining Simulation Development using a Commercial Game Engine

DTIC Science & Technology

2009-10-01

few years. The realism is stunning and the Commercial Game Industry fuels the fire of cutting edge advances in hardware and immersive experiences...Technology applies to Military training in more than just the obvious upgrades in game engines and hardware. The increased visual realism and performance...elaborate storytelling and cinematic effects provide a more immersive and compelling experience to the player. The underlying game engine technology

Where Inequality Lives in the Body: Teenage Pregnancy, Public Pedagogies and Individual Lives

ERIC Educational Resources Information Center

Luttrell, Wendy

2011-01-01

This paper is concerned with how inequality is lived in the body. I have written elsewhere about how teenage pregnancy--as both a public discourse and an individual experience--provides a compelling example of the ways that inequality is carried in bodies, minds, and hearts. The aim of this paper is to revisit my earlier analysis and consider more…

Multicultural Awareness, Knowledge, and Skills among American Counselor Trainees: Group Differences in Self-Perceived Competence Based on Dispositional and Programmatic Variables

ERIC Educational Resources Information Center

Hill, Nicole R.; Vereen, Linwood G.; McNeal, Donell; Stotesbury, Ryan

2013-01-01

Multiculturalism has been a topic of scholarly discourse and inquiry for the last three decades. As the philosophical commitment to multiculturalism continues to be endorsed by the counseling field, it is becoming increasingly imperative that we integrate theory, research, and practice in an applied and compelling manner. This article provides the…

34 CFR 31.7 - Hearing procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... authority to issue subpoenas to compel the production of documents or to compel the attendance of witnesses at an oral hearing under this part. The Secretary will attempt to make available during an oral... necessary, but that the official cannot attend an oral hearing to testify, the Secretary attempts to make...

Aram Chaos: A Long Lived Subsurface Aqueous Environment with Strong Water Resource Potential for Human Missions on Mars

NASA Astrophysics Data System (ADS)

Sibille, L.; Mueller, R. P.; Niles, P. B.; Glotch, T.; Archer, P. D.; Bell, M. S.

2015-10-01

Aram Chaos is a 280-km-wide near-circular structure near the outflow channel Ares Vallis and Aureum Chaos. It is a compelling landing site for human explorers featuring multiple science ROIs with a compelling resource ROI with polyhydrated sulfates.

Aggressive Bimodal Communication in Domestic Dogs, Canis familiaris.

PubMed

Déaux, Éloïse C; Clarke, Jennifer A; Charrier, Isabelle

2015-01-01

Evidence of animal multimodal signalling is widespread and compelling. Dogs' aggressive vocalisations (growls and barks) have been extensively studied, but without any consideration of the simultaneously produced visual displays. In this study we aimed to categorize dogs' bimodal aggressive signals according to the redundant/non-redundant classification framework. We presented dogs with unimodal (audio or visual) or bimodal (audio-visual) stimuli and measured their gazing and motor behaviours. Responses did not qualitatively differ between the bimodal and two unimodal contexts, indicating that acoustic and visual signals provide redundant information. We could not further classify the signal as 'equivalent' or 'enhancing' as we found evidence for both subcategories. We discuss our findings in relation to the complex signal framework, and propose several hypotheses for this signal's function.

Immune cell functions in iron overload.

PubMed Central

de Sousa, M

1989-01-01

A number of studies done in the last 10 years demonstrate the importance of iron in regulating the expression of T lymphoid cell surface markers, in influencing the expansion of different T cell subsets and in affecting different immune cell functions in vitro. It has been argued that some of the results obtained could be explained by the formation of iron polymers in the experimental conditions used in vitro (Soyano Fernandez & Romano, 1985). In this review the results of studies of immunological function in clinical situations of iron overload are analysed. From this analysis, it is concluded that the majority of the observations made in vitro have a counterpart in vivo, thus providing additional compelling evidence for the importance of iron as an immunoregulator. PMID:2649280

Teacher to Teacher: What Is Your Most Compelling Reason for Teaching Grammar?

ERIC Educational Resources Information Center

English Journal, 2006

2006-01-01

This article presents compelling reasons from teachers why they teach grammar. Amy Benjamin from Hendrick Hudson High School says, she teaches grammar for two reasons. The first is that grammar instruction gives students metalanguage, "language about language." The second reason is that students are interested in language--its changes and…

75 FR 29381 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-25

... compelling need to attract order flow, imposed significant competitive pressure on that exchange's need to... competitive pressures on the ISE Order Feed and ISE's compelling need to attract order flow impose significant competitive pressure on the Exchange to act equitably, fairly, and reasonably in setting its fees. B. Self...

29 CFR 575.5 - Supporting data to accompany application.

Code of Federal Regulations, 2011 CFR

2011-07-01

... REGULATIONS WAIVER OF CHILD LABOR PROVISIONS FOR AGRICULTURAL EMPLOYMENT OF 10 AND 11 YEAR OLD MINORS IN HAND... to the consequences of not meeting a compelling need for the employment of 10- and 11-year olds to... above, this would ordinarily demonstrate the compelling need for the employment of 10 and 11 year olds...

A Compelling Desire for Deafness

ERIC Educational Resources Information Center

Veale, David

2006-01-01

A case is described of a patient who has a compelling and persistent desire to become deaf. She often kept cotton wool moistened with oil in her ears and was learning sign language. Living without sound appeared to be a severe form of avoidance behavior from hyperacusis and misophonia. She had a borderline personality disorder that was associated…

Eight Issues for Learning Scientists about Education and the Economy

ERIC Educational Resources Information Center

Roschelle, Jeremy; Bakia, Marianne; Toyama, Yukie; Patton, Charles

2011-01-01

Linking research to a compelling societal interest can build financial commitments to research, bring increased attention to findings, and grow support for scaling up impacts. Among many compelling societal interests that learning scientists can cite--such as increasing the quality of life, preparing citizens to make decisions in a complex world,…

Why History? Thinking about the Uses of the Past.

ERIC Educational Resources Information Center

Stricker, Frank

1992-01-01

Discusses reasons for studying history. Suggests that compelling arguments for historical study will affect students' attitudes throughout life. Evaluates common rationales for studying history. Includes history as fun, tradition, great ideas, human folly, escapism, and nationalist legitimation. Urges that students be taught history as facts that…

Developing Aesthetically Compelling Visualizations for Documenting and Communicating Alaskan Glacier and Landscape Change

NASA Astrophysics Data System (ADS)

Molnia, B. F.

2016-12-01

For 50 years I have investigated glacier dynamics and attempted to convey this information to others. Since 2000, my focus has been on capturing and documenting decadal and century-scale Alaskan glacier and landscape change using precision repeat photography and on broadly communicate these results through simple, aesthetically compelling, unambiguous visualizations. As a young geologist, I spent the summer of 1968 on the Juneau Icefield, photographing its surface features and margins. Since then, I have taken 150,000 photographs of Alaskan glaciers and collected 5,000 historical Alaskan photographs taken by other, the earliest dating back to 1883. This database and my passion for photographing glaciers became the basis for an on-going investigation aimed at visually documenting glacier and landscapes change at more than 200 previously photographed Alaskan locations in Glacier Bay and Kenai Fjords National Parks, Prince William Sound, and the Coast Mountains. Repeat photography is a technique in which a historical and a modern photograph, both having similar fields of view, are compared and contrasted to quantitatively and qualitatively determine their similarities and differences. In precision repeat photography, both photographs have the same field of view, ideally being photographed from the identical location. Since 2000, I have conducted nearly 20 field campaigns to systematically revisit and re-photograph more than 225 fields of view previously captured in the historical photographs. As aesthetics are important in successfully communicating what has changed, substantial time and effort is invested in capturing new, comparable, generally cloud free photographs at each revisited site. The resulting modern images are then paired with similar field-of-view historical images to produce compelling, aesthetic photo pairs which depict long-term glacier, landscape, and ecosystem changes. As a few sites have multiple historical images, photo triplets or quadruplets are sometimes possible. Several approaches have been tried to produce aesthetic compelling visualization. These have included sliders, dissolves, adjacent pairs, a website, and DVDs. Providing high resolution pairs to users and letting them adapt the images to their individual needs has also been very successful.

Iran Sanctions

DTIC Science & Technology

2010-08-03

increasingly shared by major allies—is that sanctions should target Iran’s energy sector that provides about 80% of government revenues. U.S. efforts...Hamas, and Palestine Islamic Jihad. Iran’s petroleum sector generates about 20% of Iran’s GDP, and 80% of its government revenue. Iran’s oil sector is...practically, compel any foreign government to take action against one of its firms. Amendments added by P.L. 111-195, the Comprehensive Iran Sanctions

Cleaning Up the Joint: Command, Control, and Agency in American War Fighting

DTIC Science & Technology

2012-01-01

markers of the rise of professionalism . Constabulary duties on the frontier provided no compelling intellectual locus on which to build a theory of war...Docks; Construction , Equipment and Repairs; Provisions and Clothing; Ordnance and Hydrography; and Medicine and Surgery.80 Its professionalism , however...advisors seem to have convinced themselves otherwise, forcible regime change is by definition a nation- building project of the highest order.67 When

Disparity and convergence: Chinese provincial government health expenditures.

PubMed

Pan, Jay; Wang, Peng; Qin, Xuezheng; Zhang, Shufang

2013-01-01

The huge regional disparity in government health expenditures (GHE) is a major policy concern in China. This paper addresses whether provincial GHE converges in China from 1997 to 2009 using the economic convergence framework based on neoclassical economic growth theory. Our empirical investigation provides compelling evidence of long-term convergence in provincial GHE within China, but not in short-term. Policy implications of these empirical results are discussed.

Disparity and Convergence: Chinese Provincial Government Health Expenditures

PubMed Central

Pan, Jay; Wang, Peng; Qin, Xuezheng; Zhang, Shufang

2013-01-01

The huge regional disparity in government health expenditures (GHE) is a major policy concern in China. This paper addresses whether provincial GHE converges in China from 1997 to 2009 using the economic convergence framework based on neoclassical economic growth theory. Our empirical investigation provides compelling evidence of long-term convergence in provincial GHE within China, but not in short-term. Policy implications of these empirical results are discussed. PMID:23977049

The Dividing Line between Haves and Have-Nots in Home Ownership: Education, Not Student Debt. Evidence Speaks Reports, Vol 1, #17

ERIC Educational Resources Information Center

Dynarski, Susan M.

2016-01-01

Many worry that student loans are a drag on the economy, particularly the housing market. Analyses from the Federal Reserve Bank of New York, cited by leading economists, do not provide compelling evidence for this hypothesis. The New York Fed data contain no information about education. As a result, their analyses contrast the home ownership rate…

Augmented Reality for Maintenance and Repair (ARMAR)

DTIC Science & Technology

2007-08-01

800×600 resolution monocular display, whose small size and lack of an opaque “ frame ”, provides the closest experience to an eyeglass form factor, and...Alternatively, fiducials could be mounted on lightweight rigid frames that are attached to predetermined points on the maintained system. Figure...stereo at 800×600 resolution, thirty frames per second, creating a compelling experience of an augmented workspace. Based on our preliminary

Planetary science. Europa's ocean--the case strengthens.

PubMed

Stevenson, D

2000-08-25

The possibility of a subsurface ocean on Jupiter's moon Europa has been suggested on the basis of theoretical, geological, and spectroscopic arguments. But, as Stevenson explains in his Perspective, none of these arguments were compelling. In contrast, the magnetic field data obtained by the Galileo spacecraft and presented in the report by Kivelson et al., provide persuasive evidence for a conducting layer--most likely a global water ocean--near Europa's surface.

Starting Points and Destinations: Negotiating Factual and Fictional Pathways: A Response to Gilbourne, Jones and Jordan

ERIC Educational Resources Information Center

Wellard, Ian

2014-01-01

This paper provides a response to questions which emerged when reading Gilbourne et al's paper, questions it is suggested which compel us to go back to the very heart of what critical social science is (or can be) about. Central to this debate is the extent to which a perceived starting point in any investigation has implications upon the…

Korean Air Lines Flight 007: Lessons from the Past and Insights for the Future

NASA Technical Reports Server (NTRS)

Degani, Asaf; Shafto, M. (Technical Monitor)

2001-01-01

The majority of the problems pilot encounter when using automated systems center around two factors: (1) the pilot has an incomplete and inadequate model of how the autopilot works; and (2) the displays and flight manuals, provided to the pilot, are inadequate for the task. The tragic accident of Korean Air Lines Flight 007, a Boeing 747 that deviated from its intended flight path, provides a compelling case-study of problems related to pilots' use of automated systems. This paper describes what had happened and exposes two types of human-automation interaction problems: (1) The pilots of KAL were not provided with adequate information about the actual behavior of the autopilot and its mode transition logic; and (2) The autopilot onboard KAL 007 did not provide adequate information to the flight crew about its active and armed modes. Both factors, according to the International Civil Aviation Organization (1993) report on the accident, contributed to the aircraft's lethal navigation error.

Opening a door to safe abortion: international perspectives on medical abortifacient use.

PubMed

Pollack, A E; Pine, R N

2000-01-01

International experience compels us to revisit how we define and assess the safety and efficacy of medical abortifacients such as misoprostol. In some countries where safe abortion is neither accessible nor legal, even unsupervised, off-protocol use of misoprostol can provide women with a means to safely terminate pregnancy. This is due primarily to misoprostol-induced uterine contractions that cause bleeding, which in turn provides access to existing reasonable quality health services that would otherwise be unavailable. Several studies have suggested that an increase in the underground use of misoprostol in Brazil has already reduced serious complications from unsafe abortion. Thus, the availability of medical abortifacients combined with strengthened postabortion care services can legitimately be considered a public health success in countries in which safe abortion services do not exist and law reform is unlikely.

Understanding the Effects of Sampling on Healthcare Risk Modeling for the Prediction of Future High-Cost Patients

NASA Astrophysics Data System (ADS)

Moturu, Sai T.; Liu, Huan; Johnson, William G.

Rapidly rising healthcare costs represent one of the major issues plaguing the healthcare system. Data from the Arizona Health Care Cost Containment System, Arizona's Medicaid program provide a unique opportunity to exploit state-of-the-art machine learning and data mining algorithms to analyze data and provide actionable findings that can aid cost containment. Our work addresses specific challenges in this real-life healthcare application with respect to data imbalance in the process of building predictive risk models for forecasting high-cost patients. We survey the literature and propose novel data mining approaches customized for this compelling application with specific focus on non-random sampling. Our empirical study indicates that the proposed approach is highly effective and can benefit further research on cost containment in the healthcare industry.

Neurobiology of Schizophrenia: Search for the Elusive Correlation with Symptoms

PubMed Central

Mathalon, Daniel H.; Ford, Judith M.

2012-01-01

In the last half-century, human neuroscience methods provided a way to study schizophrenia in vivo, and established that it is associated with subtle abnormalities in brain structure and function. However, efforts to understand the neurobiological bases of the clinical symptoms that the diagnosis is based on have been largely unsuccessful. In this paper, we provide an overview of the conceptual and methodological obstacles that undermine efforts to link the severity of specific symptoms to specific neurobiological measures. These obstacles include small samples, questionable reliability and validity of measurements, medication confounds, failure to distinguish state and trait effects, correlation–causation ambiguity, and the absence of compelling animal models of specific symptoms to test mechanistic hypotheses derived from brain-symptom correlations. We conclude with recommendations to promote progress in establishing brain-symptom relationships. PMID:22654745

Visions Lost and Dreams Forgotten: Environmental Education, Systems Thinking, and Possible Futures in American Public Schools

ERIC Educational Resources Information Center

Cassell, John A.; Nelson, Thomas

2010-01-01

This article discusses the contributions to this special issue of "Teacher Education Quarterly." At the core of all the contributions is the compellingly urgent realization that humanity is facing, and must deal with, enormous ecological and social problems and challenges. This situation has created an urgent and compelling need centered…

75 FR 13416 - Federal Acquisition Regulation; FAR Case 2008-006, Enhanced Competition for Task- and Delivery...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-19

.... ``Unusual and Compelling Urgency.'' In the event of a FAR subpart 6.3 exception for a single contract award over $100 million including an unusual and compelling urgency exception, the commenter expresses... work. In those situations, it does not make sense in terms of costs and efficiency to require the...

K-12 School Diversity and Social Cohesion: Evidence in Support of a Compelling State Interest

ERIC Educational Resources Information Center

Mikulyuk, Ashley B.; Braddock, Jomills H.

2018-01-01

Despite existing research that demonstrates the benefits of racial diversity in education, the Court has become increasingly disinclined to allow the use of race or ethnicity in education policy targeted to increase race/ethnic diversity, absent a compelling state interest. The debate over the merits of educational diversity has almost exclusively…

12 CFR 602.4 - How to make a request.

Code of Federal Regulations, 2010 CFR

2010-01-01

... as we can. A compelling need means: (1) Someone's life or physical safety may be in danger if we do... Credit Administration. You may send it: (1) By mail to 1501 Farm Credit Drive, McLean, Virginia 22102..., that you have a “compelling need.” The FOIA Officer will tell you within 10 calendar days after...

A Conceptual Model for Leadership Transition

ERIC Educational Resources Information Center

Manderscheid, Steven V.; Ardichvili, Alexandre

2008-01-01

The purpose of this study was to develop a model of leadership transition based on an integrative review of literature. The article establishes a compelling case for focusing on leadership transitions as an area for study and leadership development practitioner intervention. The proposed model in this study identifies important success factors…

Achieving Value in Primary Care: The Primary Care Value Model.

PubMed

Rollow, William; Cucchiara, Peter

2016-03-01

The patient-centered medical home (PCMH) model provides a compelling vision for primary care transformation, but studies of its impact have used insufficiently patient-centered metrics with inconsistent results. We propose a framework for defining patient-centered value and a new model for value-based primary care transformation: the primary care value model (PCVM). We advocate for use of patient-centered value when measuring the impact of primary care transformation, recognition, and performance-based payment; for financial support and research and development to better define primary care value-creating activities and their implementation; and for use of the model to support primary care organizations in transformation. © 2016 Annals of Family Medicine, Inc.

Cellular miR-2909 RNomics governs the genes that ensure immune checkpoint regulation.

PubMed

Kaul, Deepak; Malik, Deepti; Wani, Sameena

2018-06-20

Cross-talk between coding RNAs and regulatory non-coding microRNAs, within human genome, has provided compelling evidence for the existence of flexible checkpoint control of T-Cell activation. The present study attempts to demonstrate that the interplay between miR-2909 and its effector KLF4 gene has the inherent capacity to regulate genes coding for CTLA4, CD28, CD40, CD134, PDL1, CD80, CD86, IL-6 and IL-10 within normal human peripheral blood mononuclear cells (PBMCs). Based upon these findings, we propose a pathway that links miR-2909 RNomics with the genes coding for immune checkpoint regulators required for the maintenance of immune homeostasis.

Missed and Delayed Diagnosis of Dementia in Primary Care: Prevalence and Contributing Factors

PubMed Central

Bradford, Andrea; Kunik, Mark E.; Schulz, Paul; Williams, Susan P.; Singh, Hardeep

2009-01-01

Dementia is a growing public health problem for which early detection may be beneficial. Currently, the diagnosis of dementia in primary care is dependent mostly on clinical suspicion based on patient symptomsor caregivers’ concerns and is prone to be missed or delayed. We conducted a systematic review of the literature to ascertain the prevalence and contributing factors for missed and delayed dementia diagnoses in primary care. Prevalence of missed and delayed diagnosis was estimated by abstracting quantitative data from studies of diagnostic sensitivity among primary care providers. Possible predictors and contributory factors were determined from the text of quantitative and qualitative studies of patient-, caregiver-, provider-, and system-related barriers. Overall estimates of diagnostic sensitivity varied among studies and appeared to be in part a function of dementia severity, degree of patient impairment, dementia subtype, and frequency of patient-provider contact. Major contributory factors included problems with attitudes and patient-provider communication, educational deficits, and system resource constraints. The true prevalence of missed and delayed diagnoses of dementia is unknown but appears to be high. Until the case for dementia screening becomes more compelling, efforts to promote timely detection should focus on removing barriers to diagnosis. PMID:19568149

Software solutions alone cannot guarantee useful radiology requests.

PubMed

Van Borsel, Mathias D; Devolder, Pieter Jd; Bosmans, Jan Ml

2016-11-01

Background The availability of clinical information and a pertinent clinical question can improve the diagnostic accuracy of the imaging process. Purpose To examine if an electronic request form forcing referring clinicians to provide separate input of both clinical information and a clinical question can improve the quality of the request. Material and Methods A total of 607 request forms in the clinical worklists for a computed tomography (CT) scan of the thorax, the abdomen or their combination, were examined. Using software of our own making, we examined the presence of clinical information and a clinical question before and after the introduction of a new, more compelling order method. We scored and compared the quality of the clinical information and the clinical question between the two systems and we examined the effect on productivity. Results Both clinical information and a clinical question were present in 76.7% of cases under the old system and in 95.3% under the new system ( P < 0.001). Individual characteristics of the clinical information and the clinical question however, with the exception of incompleteness, showed little improvement under the new system. There was also no significant difference between the two systems in the number of requests requiring further search. Conclusion The introduction of electronic radiology request forms compelling referring clinicians to provide separate input of clinical information and a clinical question provides only limited benefit to the quality of the request. Raising awareness among clinicians of the importance of a well-written request remains essential.

The Economic Education of Young People

ERIC Educational Resources Information Center

Prutchenkov, A.; Teriukova, T.

2010-01-01

Under the economic conditions that are new to Russia, young people are subjected to the influence of many factors. On the one hand, they are compelled to put up opposition to the economic system, while on the other hand they are compelled to be actively involved in it. In either case they have to solve the problem of how to survive in the system.…

18 CFR 385.410 - Objections to discovery, motions to quash or to compel, and protective orders (Rule 410).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Objections to discovery... RULES OF PRACTICE AND PROCEDURE Discovery Procedures for Matters Set for Hearing Under Subpart E § 385.410 Objections to discovery, motions to quash or to compel, and protective orders (Rule 410). (a...

Opinion: Is science really facing a reproducibility crisis, and do we need it to?

PubMed Central

Fanelli, Daniele

2018-01-01

Efforts to improve the reproducibility and integrity of science are typically justified by a narrative of crisis, according to which most published results are unreliable due to growing problems with research and publication practices. This article provides an overview of recent evidence suggesting that this narrative is mistaken, and argues that a narrative of epochal changes and empowerment of scientists would be more accurate, inspiring, and compelling. PMID:29531051

Clausewitz’s Elusive Center of Gravity

DTIC Science & Technology

1987-09-01

compel our enemy to do our will. Force, to counter opposing force, equips itself with the inventions of art and science . . . . Force-that is...relationship to the concentration of force. In his Summary o f the Art o f War (1838), Jomini defined the fundamental principle of war as...will to resist that provides the cohesion, the coherence, to these centers of gravity in collision. But the essence of operational art is the

Aggressive Bimodal Communication in Domestic Dogs, Canis familiaris

PubMed Central

Déaux, Éloïse C.; Clarke, Jennifer A.; Charrier, Isabelle

2015-01-01

Evidence of animal multimodal signalling is widespread and compelling. Dogs’ aggressive vocalisations (growls and barks) have been extensively studied, but without any consideration of the simultaneously produced visual displays. In this study we aimed to categorize dogs’ bimodal aggressive signals according to the redundant/non-redundant classification framework. We presented dogs with unimodal (audio or visual) or bimodal (audio-visual) stimuli and measured their gazing and motor behaviours. Responses did not qualitatively differ between the bimodal and two unimodal contexts, indicating that acoustic and visual signals provide redundant information. We could not further classify the signal as ‘equivalent’ or ‘enhancing’ as we found evidence for both subcategories. We discuss our findings in relation to the complex signal framework, and propose several hypotheses for this signal’s function. PMID:26571266

Bicarbonate Balance and Prescription in ESRD

PubMed Central

2017-01-01

The optimal approach to managing acid-base balance is less well defined for patients receiving hemodialysis than for those receiving peritoneal dialysis. Interventional studies in hemodialysis have been limited and inconsistent in their findings, whereas more compelling data are available from interventional studies in peritoneal dialysis. Both high and low serum bicarbonate levels associate with an increased risk of mortality in patients receiving hemodialysis, but high values are a marker for poor nutrition and comorbidity and are often highly variable from month to month. Measurement of pH would likely provide useful additional data. Concern has arisen regarding high-bicarbonate dialysate and dialysis-induced alkalemia, but whether these truly cause harm remains to be determined. The available evidence is insufficient for determining the optimal target for therapy at this time. PMID:27881607

Signatures of exciton condensation in a transition metal dichalcogenide

NASA Astrophysics Data System (ADS)

Kogar, Anshul; Rak, Melinda S.; Vig, Sean; Husain, Ali A.; Flicker, Felix; Joe, Young Il; Venema, Luc; MacDougall, Greg J.; Chiang, Tai C.; Fradkin, Eduardo; van Wezel, Jasper; Abbamonte, Peter

2017-12-01

Bose condensation has shaped our understanding of macroscopic quantum phenomena, having been realized in superconductors, atomic gases, and liquid helium. Excitons are bosons that have been predicted to condense into either a superfluid or an insulating electronic crystal. Using the recently developed technique of momentum-resolved electron energy-loss spectroscopy (M-EELS), we studied electronic collective modes in the transition metal dichalcogenide semimetal 1T-TiSe2. Near the phase-transition temperature (190 kelvin), the energy of the electronic mode fell to zero at nonzero momentum, indicating dynamical slowing of plasma fluctuations and crystallization of the valence electrons into an exciton condensate. Our study provides compelling evidence for exciton condensation in a three-dimensional solid and establishes M-EELS as a versatile technique sensitive to valence band excitations in quantum materials.

Moral injury: a mechanism for war-related psychological trauma in military family members.

PubMed

Nash, William P; Litz, Brett T

2013-12-01

Recent research has provided compelling evidence of mental health problems in military spouses and children, including post-traumatic stress disorder (PTSD), related to the war-zone deployments, combat exposures, and post-deployment mental health symptoms experienced by military service members in the family. One obstacle to further research and federal programs targeting the psychological health of military family members has been the lack of a clear, compelling, and testable model to explain how war-zone events can result in psychological trauma in military spouses and children. In this article, we propose a possible mechanism for deployment-related psychological trauma in military spouses and children based on the concept of moral injury, a model that has been developed to better understand how service members and veterans may develop PTSD and other serious mental and behavioral problems in the wake of war-zone events that inflict damage to moral belief systems rather by threatening personal life and safety. After describing means of adapting the moral injury model to family systems, we discuss the clinical implications of moral injury, and describe a model for its psychological treatment.

MutS HOMOLOG1-Derived Epigenetic Breeding Potential in Tomato1[OPEN

PubMed Central

Kundariya, Hardik; Xu, Ying-Zhi; Sandhu, Ajay; Yu, Jiantao; Zhang, Mingfang

2015-01-01

Evidence is compelling in support of a naturally occurring epigenetic influence on phenotype expression in land plants, although discerning the epigenetic contribution is difficult. Agriculturally important attributes like heterosis, inbreeding depression, phenotypic plasticity, and environmental stress response are thought to have significant epigenetic components, but unequivocal demonstration of this is often infeasible. Here, we investigate gene silencing of a single nuclear gene, MutS HOMOLOG1 (MSH1), in the tomato (Solanum lycopersicum) ‘Rutgers’ to effect developmental reprogramming of the plant. The condition is heritable in subsequent generations independent of the MSH1-RNA interference transgene. Crossing these transgene-null, developmentally altered plants to the isogenic cv Rutgers wild type results in progeny lines that show enhanced, heritable growth vigor under both greenhouse and field conditions. This boosted vigor appears to be graft transmissible and is partially reversed by treatment with the methylation inhibitor 5-azacytidine, implying the influence of mobile, epigenetic factors and DNA methylation changes. These data provide compelling evidence for the feasibility of epigenetic breeding in a crop plant. PMID:25736208

Behavorial effects of subchronic inhalation of toluene in adult rats

EPA Science Inventory

Whereas the acute neurobehavioral effects oftoluene are robust and well characterized, evidence for persistent effects ofrepeated exposure to this industrial solvent is less compelling. The present studies sought to determine whether repeated inhalation oftoluene caused persist...

Creating a Conference and Workshop Attendance Process with Teacher Collaboration

ERIC Educational Resources Information Center

Hironaka, Janet Hiroko

2009-01-01

This study aimed to build a professional learning community collaboratively among high school teachers for lifelong growth to minimize teacher isolation, discomfort, and fear. The study was driven by a compelling desire to extend personal learning in ways to impact the school learning community. The foundation for this study was the body of…

The Dilemmas of Peer Relationships Confronting Mathematically Gifted Female Adolescents: Nine Cases in Taiwan

ERIC Educational Resources Information Center

Kao, Chen-Yao

2011-01-01

There has been a scarcity of research studies addressing the dilemmas of peer relationships confronting gifted adolescent females. In this study, the peer relationships of nine mathematically gifted adolescent females living in Taiwan are explored using a qualitative multicase study. Data analysis revealed six compelling themes: a proclivity for…

Developing Multiple Literacies in Academic English through Service-Learning and Community Engagement

ERIC Educational Resources Information Center

Askildson, Lance R.; Kelly, Annie Cahill; Mick, Connie Snyder

2013-01-01

Research on service-learning offers compelling evidence of the advances student learners make in moral development, orientation to prosocial behavior, and curricular content retention. But who are those student learners? Most studies focus on native, dominant-culture, dominant-language students serving marginalized populations. Studies of the…

Learning Outcomes Assessment: Extrapolating from Study Abroad to International Service-Learning

ERIC Educational Resources Information Center

Rubin, Donald L.; Matthews, Paul H.

2013-01-01

For international service-learning to thrive, it must document student learning outcomes that accrue to participants. The approaches to international service-learning assessment must be compelling to a variety of stakeholders. Recent large-scale projects in study abroad learning outcomes assessment--including the Georgia Learning Outcomes of…

Practicing Critical Media Literacy Education: Developing a Community of Inquiry among Teachers Using Popular Culture

ERIC Educational Resources Information Center

Flores-Koulish, Stephanie

2010-01-01

Media literacy compels us to look anew at the most mundane, that which surrounds us: the media and our popular culture. From there media literacy compels us to accept that the media are constructed and to seek various ways to analyze them, while considering our own beliefs to evaluate for ourselves an ultimate interpretation. This process has the…

41 CFR 302-6.105 - What is a “compelling reason” warranting extension of my authorized period for claiming an actual...

Code of Federal Regulations, 2014 CFR

2014-07-01

... reasonâ warranting extension of my authorized period for claiming an actual TQSE reimbursement? 302-6.105... is a “compelling reason” warranting extension of my authorized period for claiming an actual TQSE... problems (e.g., delay in settlement on the new residence, or short-term delay in construction of the...

41 CFR 302-6.105 - What is a “compelling reason” warranting extension of my authorized period for claiming an actual...

Code of Federal Regulations, 2013 CFR

2013-07-01

... reasonâ warranting extension of my authorized period for claiming an actual TQSE reimbursement? 302-6.105... is a “compelling reason” warranting extension of my authorized period for claiming an actual TQSE... problems (e.g., delay in settlement on the new residence, or short-term delay in construction of the...

41 CFR 302-6.105 - What is a “compelling reason” warranting extension of my authorized period for claiming an actual...

Code of Federal Regulations, 2011 CFR

2011-07-01

... reasonâ warranting extension of my authorized period for claiming an actual TQSE reimbursement? 302-6.105... is a “compelling reason” warranting extension of my authorized period for claiming an actual TQSE... problems (e.g., delay in settlement on the new residence, or short-term delay in construction of the...

41 CFR 302-6.105 - What is a “compelling reason” warranting extension of my authorized period for claiming an actual...

Code of Federal Regulations, 2010 CFR

2010-07-01

... reasonâ warranting extension of my authorized period for claiming an actual TQSE reimbursement? 302-6.105... is a “compelling reason” warranting extension of my authorized period for claiming an actual TQSE... problems (e.g., delay in settlement on the new residence, or short-term delay in construction of the...

THE NATURE AND SCOPE OF STRESSFUL SPOUSAL CAREGIVING RELATIONSHIPS

PubMed Central

Davis, Linda Lindsey; Gilliss, Catherine L.; Deshefy-Longhi, Tess; Chestnutt, Deborah H.; Molloy, Margory

2013-01-01

The caregiving literature provides compelling evidence that caregiving burden and depressive symptoms are linked with stressful care relationships however relational difficulties around caregiving are seldom described in the literature. This paper presents findings from content analysis of baseline interviews with 40 Alzheimer’s disease and Parkinson’s disease spousal caregivers enrolled in a home care skill training trial who identified their care relationship as a source of care burden. Disappointment and sadness about the loss of the relationship; tension within the relationship; and care decision conflicts within the relationship were recurrent themes of relational stress in caregiving. These spousal caregivers had relationship quality scores below the mean and burden and depressive symptom scores above the means of the other caregivers in the study. These findings provide support for developing dyadic interventions that help spouses manage relational losses, care-related tensions and care decision making conflicts. PMID:21531858

Natural Conversations as a Source of False Memories in Children: Implications for the Testimony of Young Witnesses

PubMed Central

Principe, Gabrielle F.; Schindewolf, Erica

2012-01-01

Research on factors that can affect the accuracy of children’s autobiographical remembering has important implications for understanding the abilities of young witnesses to provide legal testimony. In this article, we review our own recent research on one factor that has much potential to induce errors in children’s event recall, namely natural memory sharing conversations with peers and parents. Our studies provide compelling evidence that not only can the content of conversations about the past intrude into later memory but that such exchanges can prompt the generation of entirely false narratives that are more detailed than true accounts of experienced events. Further, our work show that deeper and more creative participation in memory sharing dialogues can boost the damaging effects of conversationally conveyed misinformation. Implications of this collection of findings for children’s testimony are discussed. PMID:23129880

Dopamine prediction errors in reward learning and addiction: from theory to neural circuitry

PubMed Central

Keiflin, Ronald; Janak, Patricia H.

2015-01-01

Summary Midbrain dopamine (DA) neurons are proposed to signal reward prediction error (RPE), a fundamental parameter in associative learning models. This RPE hypothesis provides a compelling theoretical framework for understanding DA function in reward learning and addiction. New studies support a causal role for DA-mediated RPE activity in promoting learning about natural reward; however, this question has not been explicitly tested in the context of drug addiction. In this review, we integrate theoretical models with experimental findings on the activity of DA systems, and on the causal role of specific neuronal projections and cell types, to provide a circuit-based framework for probing DA-RPE function in addiction. By examining error-encoding DA neurons in the neural network in which they are embedded, hypotheses regarding circuit-level adaptations that possibly contribute to pathological error-signaling and addiction can be formulated and tested. PMID:26494275

What's in a name? Nominative determinism in the UK dental workforce.

PubMed

Sleigh, J

2016-12-16

Background Nominative determinism describes the theory that people are more likely to pursue careers that are connected to their names. Compelling research has been carried out across the medical professions that provides strong evidence for this phenomenon, but as yet its applicability to the UK dental workforce remains unknown.Aim The aim of this study was to establish the prevalence of dentally-related surnames in the UK dental workforce (dentists and dental care professionals) and compare this to the UK population.Results Dentistry may provide a surprising counter-example to prevailing theories of nominative determinism, as UK dentists are significantly less likely than the UK general population to have dentally-related surnames. This new phenomenon of 'nominative antideterminism' was not observed in the dental care professional (DCP) cohort, for whom the prevalence of dentally-related surnames was similar to that in the wider UK population.

Investigating paranormal phenomena: Functional brain imaging of telepathy.

PubMed

Venkatasubramanian, Ganesan; Jayakumar, Peruvumba N; Nagendra, Hongasandra R; Nagaraja, Dindagur; Deeptha, R; Gangadhar, Bangalore N

2008-07-01

"Telepathy" is defined as "the communication of impressions of any kind from one mind to another, independently of the recognized channels of sense". Meta-analyses of "ganzfield" studies as well as "card-guessing task" studies provide compelling evidence for the existence of telepathic phenomena. The aim of this study was to elucidate the neural basis of telepathy by examining an individual with this special ability. Using functional MRI, we examined a famous "mentalist" while he was performing a telepathic task in a 1.5 T scanner. A matched control subject without this special ability was also examined under similar conditions. The mentalist demonstrated significant activation of the right parahippocampal gyrus after successful performance of a telepathic task. The comparison subject, who did not show any telepathic ability, demonstrated significant activation of the left inferior frontal gyrus. The findings of this study are suggestive of a limbic basis for telepathy and warrant further systematic research.

Implementation of consumer providers into mental health intensive case management teams.

PubMed

Hamilton, Alison B; Chinman, Matthew; Cohen, Amy N; Oberman, Rebecca Shoai; Young, Alexander S

2015-01-01

In mental health care, consumer providers (CPs) are individuals with serious mental illness (SMI) who draw upon their lived experiences while providing services to others with SMI. Implementation of CPs has proven to be challenging in a variety of settings. The PEER project (Peers Enhancing Recovery) involved rolling out CPs using an implementation science model and evaluating implementation and impact in mental health treatment settings (three intervention, three control). In qualitative interviews, facilitators and challenges to implementation were described by the CPs, their team members, clients, and study researchers. Site preparation, external facilitation, and positive, reinforcing experiences with CPs facilitated implementation. Role definitions and deficiencies in CPs' technical knowledge posed challenges to implementation. Sustainability was not realized due to insufficient resources. However, implementation was positive overall, characterized by diffusion of innovation concepts of high relative advantage, strong trialability, compatibility with prevailing norms, compelling observability, and relatively low complexity. By preparing and working systematically with intervention sites to incorporate new services, implementation was strengthened and challenges were minimized.

Fusarium mycotoxins: a trans-disciplinary overview

USDA-ARS?s Scientific Manuscript database

Due to health risks and economic losses associated with mycotoxins produced by plant pathogenic Fusarium species, there is a compelling need for improved understanding of these fungi from across diverse perspectives and disciplinary approaches. Phylogenetic studies have made tremendous progress in d...

Magnetic force and work: an accessible example

NASA Astrophysics Data System (ADS)

Gates, Joshua

2014-05-01

Despite their physics instructors’ arguments to the contrary, introductory students can observe situations in which there seems to be compelling evidence for magnetic force doing work. The counterarguments are often highly technical and require physics knowledge beyond the experience of novice students, however. A simple example is presented which can illustrate that all may not be what it seems when energy transfer and the magnetic force are involved. Excel and Python simulations of the process are also provided.

The NYU System for MUC-6 or Where’s the Syntax?

DTIC Science & Technology

1995-01-01

34 and only in the face of compelling syntactic or semantic evidence, in a (nearly) deterministic manner . Speed was particularly an issue for MUC-6...thank BBN Systems and Technologies for providing us with this tagger. 168 Name Recognitio n The input stage is followed by several stages of pattern...Group Recognitio n The third stage of pattern matching recognizes verb groups : simple tensed verbs ("sleeps"), and verbs with auxiliaries ("will sleep

State Department of Public Health v. Wells.

PubMed

1989-09-07

The Alabama Court of Civil Appeals decided that under state law the results of an inmate's HIV-AIDS test remain confidential. The release of test results may be done by physicians or state health officers to third parties where the risk of disease transmittal is foreseeable, real, or probable. An inmate awaiting transfer from a county jail to a state prison voluntarily submitted to HIV testing, and the county sheriff sought to compel release of the results. Under the state Notifiable Diseases Act, the county could not compel testing of those inmates awaiting transfer, nor could it compel release of the results of that testing. The results are confidential unless the test is compulsory or the inmate gives written consent, and then the discretion to divulge the results resides in physicians or state health personnel rather than in the courts.

TAS::89 0927::TAS RECOVERY - The Lean Green Energy Controller Machine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teeter, John; Wang, Gene; Moss, David

Achieving efficiency improvements and providing demand-response programs have been identified as key elements of our national energy initiative. The residential market is the largest, yet most difficult, segment to engage in efforts to meet these objectives. This project developed Energy Management System that engages the consumer and enables Smart Grid services, applications, and business processes to address this need. Our innovative solution provides smart controller providing dynamic optimization of energy consumption for the residential energy consumer. Our solution extends the technical platform to include a cloud based Internet of Things (IoT) aggregation of data sensors and actuators the go beyondmore » energy management and extend to life style services provided through compelling mobile and console based user experiences.« less

Lack of prosociality in great apes, capuchin monkeys and spider monkeys: convergent evidence from two different food distribution tasks

PubMed Central

Amici, Federica; Visalberghi, Elisabetta; Call, Josep

2014-01-01

Prosociality can be defined as any behaviour performed to alleviate the needs of others or to improve their welfare. Prosociality has probably played an essential role in the evolution of cooperative behaviour and several studies have already investigated it in primates to understand the evolutionary origins of human prosociality. Two main tasks have been used to test prosociality in a food context. In the Platforms task, subjects can prosocially provide food to a partner by selecting a prosocial platform over a selfish one. In the Tokens task, subjects can prosocially provide food to a partner by selecting a prosocial token over a selfish one. As these tasks have provided mixed results, we used both tasks to test prosociality in great apes, capuchin monkeys and spider monkeys. Our results provided no compelling evidence of prosociality in a food context in any of the species tested. Additionally, our study revealed serious limitations of the Tokens task as it has been previously used. These results highlight the importance of controlling for confounding variables and of using multiple tasks to address inconsistencies present in the literature. PMID:25209941

Structuring U.S. Ground Forces to Meet All Threats

DTIC Science & Technology

2008-04-30

After the Indians breeched the August 1868 treaty, Sheridan planned an offensive to gain control of the hostile tribes . He restricted operations...winter, compelled the majority to acquiesce45. Despite these major successes, a few tribes escaped and continued to attack white settlers through the...winter of 186946. Sheridan sent General George Custer with a small detachment of Indian scouts to find, meet with, and compel the remaining tribes

39 CFR 230.17 - If an attempt is made to compel production of reports and records during the employee's testimony...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false If an attempt is made to compel production of reports and records during the employee's testimony, what is an Office of Inspector General employee directed to do? 230.17 Section 230.17 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION OFFICE OF INSPECTOR GENERAL Rules...

Memory for color reactivates color processing region.

PubMed

Slotnick, Scott D

2009-11-25

Memory is thought to be constructive in nature, where features processed in different cortical regions are synthesized during retrieval. In an effort to support this constructive memory framework, the present functional magnetic resonance imaging study assessed whether memory for color reactivated color processing regions. During encoding, participants were presented with colored and gray abstract shapes. During retrieval, old and new shapes were presented in gray and participants responded 'old-colored', 'old-gray', or 'new'. Within color perception regions, color memory related activity was observed in the left fusiform gyrus, adjacent to the collateral sulcus. A retinotopic mapping analysis indicated this activity occurred within color processing region V8. The present feature specific evidence provides compelling support for a constructive view of memory.

Learning Bridge Tool to Improve Student Learning, Preceptor Training, and Faculty Teamwork

PubMed Central

Cawley, Pauline; Arendt, Cassandra S.

2011-01-01

Objectives To implement a Learning Bridge tool to improve educational outcomes for pharmacy students as well as for preceptors and faculty members. Design Pharmacy faculty members collaborated to write 9 case-based assignments that first-year pharmacy (P1) students worked with preceptors to complete while at experiential sites. Assessment Students, faculty members, and preceptors were surveyed about their perceptions of the Learning Bridge process. As in our pilot study,1 the Learning Bridge process promoted student learning. Additionally, the Learning Bridge assignments familiarized preceptors with the school's P1 curriculum and its content. Faculty teamwork also was increased through collaborating on the assignments. Conclusions The Learning Bridge assignments provided a compelling learning environment and benefited students, preceptors, and faculty members. PMID:21655400

NMR signature of evolution of ductile-to-brittle transition in bulk metallic glasses.

PubMed

Yuan, C C; Xiang, J F; Xi, X K; Wang, W H

2011-12-02

The mechanical properties of monolithic metallic glasses depend on the structures at atomic or subnanometer scales, while a clear correlation between mechanical behavior and structures has not been well established in such amorphous materials. In this work, we find a clear correlation of (27)Al NMR isotropic shifts with a microalloying induced ductile-to-brittle transition at ambient temperature in bulk metallic glasses, which indicates that the (27)Al NMR isotropic shift can be regarded as a structural signature to characterize plasticity for this metallic glass system. The study provides a compelling approach for investigating and understanding the mechanical properties of metallic glasses from the point of view of electronic structure. © 2011 American Physical Society

Book Review: Water Diplomacy: A Negotiated Approach to Managing Complex Water Networks

NASA Astrophysics Data System (ADS)

Hossain, Faisal

2013-01-01

All nations have built their economies around water that is naturally available. Almost all sectors of the economy depend on water. Yet there is conflict among various users for the finite amount of water that is available. Managers and practitioners have long held the notion that competition rather than collaboration is the solution when there is conflict. Water Diplomacy: A Negotiated Approach to Managing Complex Water Networks, by Shafiqul Islam and Lawrence Susskind, provides a refreshingly compelling alternative to overcoming water conflicts. The book argues that the dynamic sociopolitical and socioeconomic constraints of water resources are best addressed in a "diplomacy" framework. The book rebuts, using several case studies, the technically rigid competition approach of today's water sharing practice.

Learning bridge tool to improve student learning, preceptor training, and faculty teamwork.

PubMed

Karimi, Reza; Cawley, Pauline; Arendt, Cassandra S

2011-04-11

To implement a Learning Bridge tool to improve educational outcomes for pharmacy students as well as for preceptors and faculty members. Pharmacy faculty members collaborated to write 9 case-based assignments that first-year pharmacy (P1) students worked with preceptors to complete while at experiential sites. Students, faculty members, and preceptors were surveyed about their perceptions of the Learning Bridge process. As in our pilot study,(1) the Learning Bridge process promoted student learning. Additionally, the Learning Bridge assignments familiarized preceptors with the school's P1 curriculum and its content. Faculty teamwork also was increased through collaborating on the assignments. The Learning Bridge assignments provided a compelling learning environment and benefited students, preceptors, and faculty members.

The Geospace Mission Definition Team report

NASA Astrophysics Data System (ADS)

Kintner, P.; Spann, J.

The Geospace Mission Definition Team (GMDT) is the portion of the Living With a Star (LWS) Program that has been charged by NASA to examine how the Geospace environment responds to solar variability. The goal is to provide science recommendations that guide NASA in the formulation of Geospace missions. The GMDT's first meeting with September 10, 2001 and has met on four subsequent dates. The top level space weather effects were initially defined by the LWS Science Architecture Team (SAT). From these effects the GMDT has distilled general objectives and specific objectives. These objectives have been prioritized and compelling science questions have been identified that are required to address the objectives. A set of candidate missions has been defined with minimum, baseline, and augmentation measurements identified. The priority science questions focus on two broad areas: (1) ionospheric variability, especially at mid-latitudes, that affects navigation and communications and (2) the source, acceleration mechanisms, and sinks of the radiation belts that degrade satellite lifetimes, produce surface charging, and threaten manned space flight. In addition the measurements required for understanding ionospheric variability will also address science issues associated with thermospheric satellite drag and orbital prediction. Candidate missions to address these science focii have been developed and studied. The team concludes that it is possible to address the compelling science questions with a cost effective program that yields major advances in our understanding of space weather science, that inspires and validates better ionospheric and magnetospheric models, and that will enable operational advances mitigating the societal impacts of space weather.

Folate and carcinogenesis-mechanisms

USDA-ARS?s Scientific Manuscript database

A large and growing body of both pre-clinical and clinical studies pertaining to colorectal neoplasms constitutes the most compelling evidence for the protective effect of folate against the development of cancer, although evidence is also accruing in this regard for cancers of the breast, lung, pan...

Innovation: Examining Workplace Learning in New Enterprises.

ERIC Educational Resources Information Center

Fenwick, Tara

2003-01-01

A study of women entrepreneurs explored learning in the process of business start-up, conditions that foster innovative learning (challenge/variety, compelling social purpose, recognition and pride), and forms of innovative learning (generating multiple ideas, scanning, optimizing, problem solving, self-confidence). Innovative processes involved…

Elementary Principals' Strategies for Managing the Educational Technology Refresh Process: A Case Study

ERIC Educational Resources Information Center

Denton, Edward A.

2011-01-01

Increased uses of educational technology by students and teachers in recent years have compelled elementary principals to expand educational technology resources and replace educational technology resources at the end of it's service life. The purpose of this study was to investigate strategies and practices employed by elementary principals…

Anxiety Sensitivity and Panic Attacks: A 1-Year Longitudinal Study

ERIC Educational Resources Information Center

Li, Wen; Zinbarg, Richard E.

2007-01-01

The hypothesis that anxiety sensitivity (AS) is a risk factor for panic genesis has obtained compelling support, but the clinical/practical importance of AS in panic genesis has been questioned. In addition, the association between panic experience and AS increase has not been clearly demonstrated. Through this 1-year longitudinal study among…

Challenge-Based Learning: An Approach for Our Time

ERIC Educational Resources Information Center

Johnson, Laurence F.; Smith, Rachel S.; Smythe, J. Troy; Varon, Rachel K.

2009-01-01

Study after study documents the skills the American workforce needs to stay competitive in a global marketplace, yet increasingly employers are compelled to look overseas for those skills. The authors advocate for a different manner of thinking, focused on engaging students in work that is relevant to the world they see, encouraging them to take…

Soil health: an emergent set of soil properties that result from synergy among agricultural management practices

USDA-ARS?s Scientific Manuscript database

The responses of a selected soil microbial property to a single agricultural management practice are often inconsistent among field studies, possibly reflecting the site-specific nature of field studies. An equally compelling explanation is that in complex systems where outcomes are the result of n...

Relational Rurals: Some Thoughts on Relating Things and Theory in Rural Studies

ERIC Educational Resources Information Center

Heley, Jesse; Jones, Laura

2012-01-01

This paper considers how shifts within the social sciences towards conceptualising spatiality in relational terms have unfolded in rural studies in particular ways over the past decade or so. A period in which networks, connections, flows and mobility have all established themselves as compelling conceptual frames for research, the rural has…

Bicarbonate Balance and Prescription in ESRD.

PubMed

Abramowitz, Matthew K

2017-03-01

The optimal approach to managing acid-base balance is less well defined for patients receiving hemodialysis than for those receiving peritoneal dialysis. Interventional studies in hemodialysis have been limited and inconsistent in their findings, whereas more compelling data are available from interventional studies in peritoneal dialysis. Both high and low serum bicarbonate levels associate with an increased risk of mortality in patients receiving hemodialysis, but high values are a marker for poor nutrition and comorbidity and are often highly variable from month to month. Measurement of pH would likely provide useful additional data. Concern has arisen regarding high-bicarbonate dialysate and dialysis-induced alkalemia, but whether these truly cause harm remains to be determined. The available evidence is insufficient for determining the optimal target for therapy at this time. Copyright © 2017 by the American Society of Nephrology.

Antibiotic Algae by Chemical Surface Engineering.

PubMed

Kerschgens, Isabel P; Gademann, Karl

2018-03-02

Chemical cell-surface engineering is a tool for modifying and altering cellular functions. Herein, we report the introduction of an antibiotic phenotype to the green alga Chlamydomonas reinhardtii by chemically modifying its cell surface. Flow cytometry and confocal microscopy studies demonstrated that a hybrid of the antibiotic vancomycin and a 4-hydroxyproline oligomer binds reversibly to the cell wall without affecting the viability or motility of the cells. The modified cells were used to inhibit bacterial growth of Gram-positive Bacillus subtilis cultures. Delivery of the antibiotic from the microalgae to the bacterial cells was verified by microscopy. Our studies provide compelling evidence that 1) chemical surface engineering constitutes a useful tool for the introduction of new, previously unknown functionality, and 2) living microalgae can serve as new platforms for drug delivery. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

No Compelling Evidence that Preferences for Facial Masculinity Track Changes in Women's Hormonal Status.

PubMed

Jones, Benedict C; Hahn, Amanda C; Fisher, Claire I; Wang, Hongyi; Kandrik, Michal; Han, Chengyang; Fasolt, Vanessa; Morrison, Danielle; Lee, Anthony J; Holzleitner, Iris J; O'Shea, Kieran J; Roberts, S Craig; Little, Anthony C; DeBruine, Lisa M

2018-06-01

Although widely cited as strong evidence that sexual selection has shaped human facial-attractiveness judgments, findings suggesting that women's preferences for masculine characteristics in men's faces are related to women's hormonal status are equivocal and controversial. Consequently, we conducted the largest-ever longitudinal study of the hormonal correlates of women's preferences for facial masculinity ( N = 584). Analyses showed no compelling evidence that preferences for facial masculinity were related to changes in women's salivary steroid hormone levels. Furthermore, both within-subjects and between-subjects comparisons showed no evidence that oral contraceptive use decreased masculinity preferences. However, women generally preferred masculinized over feminized versions of men's faces, particularly when assessing men's attractiveness for short-term, rather than long-term, relationships. Our results do not support the hypothesized link between women's preferences for facial masculinity and their hormonal status.

The X-Ray Surveyor Mission Concept Study: Forging the Path to NASA Astrophysics 2020 Decadal Survey Prioritization

NASA Technical Reports Server (NTRS)

Gaskin, Jessica; Ozel, Feryal; Vikhlinin, Alexey

2016-01-01

The X-Ray Surveyor mission concept is unique among those being studied for prioritization in the NASA Astrophysics 2020 Decadal Survey. The X-Ray Surveyor mission will explore the high-energy Universe; providing essential and complimentary observations to the Astronomy Community. The NASA Astrophysics Roadmap (Enduring Quests, Daring Visions) describes the need for an X-Ray Observatory that is capable of addressing topics such as the origin and growth of the first supermassive black holes, galaxy evolution and growth of the cosmic structure, and the origin and evolution of the stars that make up our Universe. To address these scientifically compelling topics and more, an Observatory that exhibits leaps in capability over that of previous X-Ray Observatories in needed. This paper describes the current status of the X-Ray Surveyor Mission Concept Study and the path forward, which includes scientific investigations, technology development, and community participation.

The X-Ray Surveyor mission concept study: forging the path to NASA astrophysics 2020 decadal survey prioritization

NASA Astrophysics Data System (ADS)

Gaskin, Jessica; Özel, Feryal; Vikhlinin, Alexey

2016-07-01

The X-Ray Surveyor mission concept is unique among those being studied for prioritization in the NASA Astrophysics 2020 Decadal Survey. The X-Ray Surveyor mission will explore the high-energy Universe; providing essential and complimentary observations to the Astronomy Community. The NASA Astrophysics Roadmap (Enduring Quests, Daring Visions) describes the need for an X-Ray Observatory that is capable of addressing topics such as the origin and growth of the first supermassive black holes, galaxy evolution and growth of the cosmic structure, and the origin and evolution of the stars that make up our Universe. To address these scientifically compelling topics and more, an Observatory that exhibits leaps in capability over that of previous X-Ray Observatories in needed. This paper describes the current status of the X-Ray Surveyor Mission Concept Study and the path forward, which includes scientific investigations, technology development, and community participation.

The Washington Needle Depot: fitting healthcare to injection drug users rather than injection drug users to healthcare: moving from a syringe exchange to syringe distribution model

PubMed Central

2010-01-01

Needle exchange programs chase political as well as epidemiological dragons, carrying within them both implicit moral and political goals. In the exchange model of syringe distribution, injection drug users (IDUs) must provide used needles in order to receive new needles. Distribution and retrieval are co-existent in the exchange model. Likewise, limitations on how many needles can be received at a time compel addicts to have multiple points of contact with professionals where the virtues of treatment and detox are impressed upon them. The centre of gravity for syringe distribution programs needs to shift from needle exchange to needle distribution, which provides unlimited access to syringes. This paper provides a case study of the Washington Needle Depot, a program operating under the syringe distribution model, showing that the distribution and retrieval of syringes can be separated with effective results. Further, the experience of IDUs is utilized, through paid employment, to provide a vulnerable population of people with clean syringes to prevent HIV and HCV. PMID:20047690

National Security Personnel System: An Optimization Strategy for Implementing Pay-for-Performance

DTIC Science & Technology

2006-03-15

leaders who can be more nimble and more adaptive in an environment of unprecedented cultural change. Unfortunately, for Exelon, these were qualities...has been thrust upon them. Therefore, to effect a successful cultural change, DoD leaders will have to communicate a compelling reason for...additional level of risk perceived by their employees.30 Communication. Perhaps, the most important thing leaders can do is to articulate clear, compelling

Gold

USGS Publications Warehouse

Kirkemo, Harold; Newman, William L.; Ashley, Roger P.

1998-01-01

Through the ages, men and women have cherished gold, and many have had a compelling desire to amass great quantities of it -- so compelling a desire, in fact, that the frantic need to seek and hoard gold has been aptly named "gold fever." Gold was among the first metals to be mined because it commonly occurs in its native form -- that is, not combined with other elements -- because it is beautiful and imperishable, and because exquisite objects can be made from it.

A compelling desire for deafness.

PubMed

Veale, David

2006-01-01

A case is described of a patient who has a compelling and persistent desire to become deaf. She often kept cotton wool moistened with oil in her ears and was learning sign language. Living without sound appeared to be a severe form of avoidance behavior from hyperacusis and misophonia. She had a borderline personality disorder that was associated with a poor sense of self. Her desire to be deaf may be one aspect of gaining an identity for herself and to compensate for feeling like an alien and gaining acceptance in the Deaf community. Will a compelling desire for deafness ever become a recognized mental disorder one day for which hearing patients may be offered elective deafness after a period of assessment and living like a deaf person? Those working in the field of deafness should be aware that individuals may occasionally be seeking elective deafness or self-inflicting deafness to obtain a hearing aid.

The next generation Internet and health care: a civics lesson for the informatics community.

PubMed

Shortliffe, E H

1998-01-01

The Internet provides one of the most compelling examples of the way in which government research investments can, in time, lead to innovations of broad social and economic impact. This paper reviews the history of the Internet's evolution, emphasizing in particular its relationship to medical informatics and to the nation's health-care system. Current national research programs are summarized and the need for more involvement by the informatics community and by federal health-care agencies is emphasized.

NOVA-2 -- A Digital Computer Program for Analyzing Nuclear Overpressure Effects on Aircraft. Part 1. Theory

DTIC Science & Technology

1976-08-01

extensive areas of good agreement with measured loadings where the prediction is based on acoustic theory. Acoustic theory as applied to thin airfoils...Acoustic thaory ha« baen demonstrated by references 12 through 18 to provide fairly good agreeaent with measured airloads due to blast and shock... ia found to riae to large values near the leading edge. Higher observed values of Ac further rearward of the leading edge ere found to compel

Dietary fiber and protein: nutritional therapy in chronic kidney disease and beyond.

PubMed

Evenepoel, Pieter; Meijers, Björn K

2012-02-01

The health benefits of dietary fiber in the general population are increasingly recognized. Krishnamurthy et al. provide compelling evidence that chronic kidney disease (CKD) further augments these benefits. CKD, besides a microinflammatory state, is a state of increased proteolytic fermentation. Both these harmful conditions are exacerbated by dietary protein and reversed by dietary fiber. Future nutrition guidelines should consider recommending a higher consumption of dietary fiber or potassium-free alternatives such as prebiotics in CKD patients.

The next generation Internet and health care: a civics lesson for the informatics community.

PubMed Central

Shortliffe, E. H.

1998-01-01

The Internet provides one of the most compelling examples of the way in which government research investments can, in time, lead to innovations of broad social and economic impact. This paper reviews the history of the Internet's evolution, emphasizing in particular its relationship to medical informatics and to the nation's health-care system. Current national research programs are summarized and the need for more involvement by the informatics community and by federal health-care agencies is emphasized. PMID:9929176

The WSTIAC Quarterly. Volume 9, Number 4

DTIC Science & Technology

2010-04-28

elements of command– Major Eric D. Trias Captain Bryan M. Bell US Air Force You have to know the past to understand the present. — Carl Sagan This article is...Quarterly, Volume 9, Number 4 3 INTRODUCTION Carl von Clausewitz defined war as “…an act of violence intended to compel our opponent to fulfill our will...controlled systems. NOTES & REFERENCES ‡ Joint Pub 3-13 provides the doctrinal foundation for the conduct of IO in joint operations. [1] von Clausewitz, Carl

Mid-course Corrections: The Army Reserve’s Campaign to Mitigate Its Officer Vacancies during the Global War on Terror

DTIC Science & Technology

2012-05-17

external civilian success factors rather than recognized competence within the Army organization. Finally, this produced a zero net gain for USAR...officers prior to their MSO and the after-tax net result for a $6,000 bonus was not compelling for many Soldiers. The USAR experienced a noticeable...the maximum active duty end strength. Thus, Congress created Active Duty for Operational Support ( ADOS ). 91 This short-term policy provided

Relative bioavailability of arsenic contaminated soils in a mouse model

EPA Science Inventory

Exposure to As contaminated soils compels extensive soil cleanups so that human health risks are minimized. In order to improve exposure estimates and potentially reduce remediation costs, determination of the bioavailability of As in soils is needed. The objective of this study ...

The Science and Experimental Equipment for the 12 GeV Upgrade of CEBAF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arrington, John; Bernstein, Aron; Brooks, William

2005-01-10

This Conceptual Design Report (CDR) presents the compelling scientific case for upgrading the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab to 12 GeV. Such a facility will make profound contributions to the study of hadronic matter.

Staples.com: Focus on Usability.

ERIC Educational Resources Information Center

McCann, Tom; Hynes, Colin

2002-01-01

Describes the Staples.com electronic commerce Web site; discusses its steady growth rate; and details two case studies in which data from a variety of sources were used to identify and resolve site usability issues and which are supported by compelling ROI (return on investment) figures. (Author/LRW)

Teaching Qualitative Research to Practitioner-Researchers

ERIC Educational Resources Information Center

Cox, Rebecca D.

2012-01-01

Practitioner-researchers are well-positioned to apply qualitative methods to the study of significant problems of educational practice. However, while learning the skills of qualitative inquiry, practitioners may be compelled by forces outside of qualitative research classrooms to think quantitatively. In this article, the author considers two…

International Students' Confidence and Academic Success

ERIC Educational Resources Information Center

Telbis, Nicola Miky

2013-01-01

Research shows that the international student population is showing significant growth. Studies also show that foreign students are encountering difficulties such as social adaptability, language barriers, academic ability, and financial need. There is compelling evidence that establishes a correlation between a person's self-efficacy and his or…

A Demonstration of Sample Segregation

ERIC Educational Resources Information Center

Fritz, Mark D.; Brumbach, Stephen B.; Hartman, JudithAnn R.

2005-01-01

The demonstration of sample segregation, which is simple, and visually compelling illustrates the importance of sample handling for students studying analytical chemistry and environmental chemistry. The mixture used in this demonstration has two components, which have big particle size, and different colors, which makes the segregation graphic.

The value of health care information exchange and interoperability.

PubMed

Walker, Jan; Pan, Eric; Johnston, Douglas; Adler-Milstein, Julia; Bates, David W; Middleton, Blackford

2005-01-01

In this paper we assess the value of electronic health care information exchange and interoperability (HIEI) between providers (hospitals and medical group practices) and independent laboratories, radiology centers, pharmacies, payers, public health departments, and other providers. We have created an HIEI taxonomy and combined published evidence with expert opinion in a cost-benefit model. Fully standardized HIEI could yield a net value of dollar 77.8 billion per year once fully implemented. Nonstandardized HIEI offers smaller positive financial returns. The clinical impact of HIEI for which quantitative estimates cannot yet be made would likely add further value. A compelling business case exists for national implementation of fully standardized HIEI.

An official multi-society statement: the role of clinical research results in the practice of critical care medicine.

PubMed

Tonelli, Mark R; Curtis, J Randall; Guntupalli, Kalpalatha K; Rubenfeld, Gordon D; Arroliga, Alejandro C; Brochard, Laurent; Douglas, Ivor S; Gutterman, David D; Hall, Jesse R; Kavanagh, Brian P; Mancebo, Jordi; Misak, Cheryl J; Simpson, Steven Q; Slutsky, Arthur S; Suffredini, Anthony F; Thompson, B Taylor; Ware, Lorraine B; Wheeler, Arthur P; Levy, Mitchell M

2012-05-15

While the results of clinical research are clearly valuable in the care of critically ill patients, the limitations of such information and the role of other forms of medical knowledge for clinical decision making have not been carefully examined. The leadership of three large professional societies representing critical care practitioners convened a diverse group representing a wide variety of views regarding the role of clinical research results in clinical practice to develop a document to serve as a basis for agreement and a framework for ongoing discussion. Consensus was reached on several issues. While the results of rigorous clinical research are important in arriving at the best course of action for an individual critically ill patient, other forms of medical knowledge, including clinical experience and pathophysiologic reasoning, remain essential. No single source of knowledge is sufficient to guide clinical decisions, nor does one kind of knowledge always take precedence over others. Clinicians will find clinical research compelling for a variety of reasons that go beyond study design. While clinical practice guidelines and protocols based upon clinical research may improve care and decrease variability in practice, clinicians must be able to understand and articulate the rationale as to why a particular protocol or guideline is used or why an alternative approach is taken. Making this clinical reasoning explicit is necessary to understand practice variability. Understanding the strengths and weaknesses of different kinds of medical knowledge for clinical decision making and factors beyond study design that make clinical research compelling to clinicians can provide a framework for understanding the role of clinical research in practice.

Long-range Transport of Asian Dust Storms: A Satellite/Surface Perspective on Societal and Scientific Influence

NASA Technical Reports Server (NTRS)

2007-01-01

Among the many components contributing to air pollution, airborne mineral dust plays an important role due to its biogeochemical impact on the ecosystem and its radiative forcing effect on the weather/climate system. As much as one-third to half of the global dust emissions, estimated about 800 Tg, are introduced annually into Earth's atmosphere from various deserts in China. Asian dust storm outbreaks are believed to have persisted for hundreds and thousands years over the vast territory of north and northwest China, but not until recent decades that many studies reveal the compelling evidence in recognizing the importance of these eolian dust particles for forming Chinese Loess Plateau and for biogeochemical cycling in the North Pacific Ocean to as far as in the Greenland ice-sheets through long-range transport. The Asian dust and air pollution aerosols can be detected by its colored appearance on current Earth observing satellites and its evolution monitored by satellite and surface network. In this paper, we will demonstrate the capability of a new satellite algorithm, called Deep Blue, to retrieve aerosol properties, particularly but not limited to, over bright-reflecting surfaces such as urban areas and deserts. Recently, many field campaigns were designed and executed to study the compelling variability in spatial and temporal scale of both pollution-derived and naturally occurring aerosols, which often exist in high concentrations over eastern Asia and along the rim of the western Pacific. We will provide an overview of the outbreak of Asian dust storms, near source/sink and their evolution along transport pathway, from space and surface observations. The climatic effects and societal impacts of the Asian dusts will be addressed in depth. (to be presented in the International Workshop on Semi-Arid Land Surface-

Compelling teaching with the four Cs: caring, comedy, creativity, and challenging.

PubMed

Story, Lachel; Butts, Janie B

2010-05-01

The traditional classroom, particularly in nursing, often is stifling to students and teachers. A dynamic co-learning experience creates a potential to move students from merely obtaining knowledge to practice. This article presents an exemplar of the transformative learning process within the nursing education setting. The concepts forming this compelling teaching approach are caring, comedy, creativity, and challenging (the four Cs). Through this innovative teaching method, opportunities are created for authentic co-learning to occur.

Perceptions of the Principal Evaluation Process and Performance Criteria: A Qualitative Study of the Challenge of Principal Evaluation

ERIC Educational Resources Information Center

Faginski-Stark, Erica; Casavant, Christopher; Collins, William; McCandless, Jason; Tencza, Marilyn

2012-01-01

Recent federal and state mandates have tasked school systems to move beyond principal evaluation as a bureaucratic function and to re-imagine it as a critical component to improve principal performance and compel school renewal. This qualitative study investigated the district leaders' and principals' perceptions of the performance evaluation…

Ways with Data: Understanding Coding as Writing

ERIC Educational Resources Information Center

Lindgren, Chris

2017-01-01

In this dissertation, I report findings from an exploratory case-study about Ray, a web developer, who works on a data-driven news team that finds and tells compelling stories with large sets of data. I implicate this case of Ray's coding on a data team in a writing studies epistemology, which is guided by the following question: "What might…

The Pilot Study of Integrating Spatial Educational Experiences (Isee) in an Undergraduate Crop Production Course

ERIC Educational Resources Information Center

Mitzman, Stephanie; Snyder, Lori Unruh; Schulze, Darrell G.; Owens, Phillip R.; Bracke, Marianne Stowell

2011-01-01

Recent National Research Council reports make compelling arguments for the need to incorporate spatial abilities and use spatial technologies throughout our educational system. We conducted a pilot study to determine the pedagogical effectiveness of teaching with geographic information systems (GIS) by using a web-based GIS tool of Indiana soils.…

National Qualification Frameworks: Developing Research Perspectives

ERIC Educational Resources Information Center

Fernie, Scott; Pilcher, Nick

2009-01-01

Arguments for National Qualification Frameworks (NQF) are compelling. Indeed, such frameworks are now an international phenomenon. Yet, few studies take a critical perspective and challenge the broad assumptions underpinning NQF. Arguments presented in this paper attempt to open a debate within the higher education community that draws attention…

Dimensions of Publicness and Performance in Substance Abuse Treatment Organizations

ERIC Educational Resources Information Center

Heinrich, Carolyn J.; Fournier, Elizabeth

2004-01-01

Changes in funding, clientele, and treatment practices of public and privately owned substance abuse treatment programs, compelled in part by increased cost containment pressures, have prompted researchers' investigations of the implications of organizational form for treatment programs. These studies primarily probe associations between ownership…

Nuclear Weapons and Communication Studies: A Review Essay.

ERIC Educational Resources Information Center

Taylor, Bryan C.

1998-01-01

Reviews the body of work inspired by the late Cold War period, where nuclear weapons briefly became a compelling object for communication scholars. Considers the prospects for nuclear communication scholarship in post-Cold War culture. Discusses "nuclear criticism" and issues regarding the bomb in communication. (SC)

Emotion in Organizations: Resources for Business Educators

ERIC Educational Resources Information Center

Bowen, Janine L.

2014-01-01

The study of emotion in organizations has advanced considerably in recent years. Several aspects of this research area make calls for its translation into business curricula particularly compelling. First, potential benefits to students are significant. Second, important contributions to this scholarship often come from the classroom. Third,…

Healthcare e-commerce: connecting with patients.

PubMed

Joslyn, J S

2001-01-01

Electronically connecting with patients is a challenging frontier at which technical hurdles are probably exceeded by political, legal, and other barriers. The rise of consumerism, however, compels a response focused more on revenue and strategic advantage than on pure cost savings. Among the difficulties faced by providers is choosing among various models of connectivity and component function. Emerging models include "free-floating" personal medical records largely independent of the office-based physician, systems with compatible and intertwined physician and consumer relationships using an application services provider office practice system, and systems that connect patients and providers through e-mail, office triage, prescription refills, scheduling, and so on. This article discusses these and other combinations of technology that significantly overcome the barriers involved and that may be woven together to provide solutions uniquely suited to various competitive situations.

Making sense of behavioral irregularities of great apes.

PubMed

Fabrega, Horacio

2006-01-01

Psychopathology, mental illness, and psychiatric treatment are concepts relevant to modern medicine and medical psychology and replete with cumbersome intellectual and literary baggage. They bear the imprint of suppositions, world views, and general beliefs and values exemplified in the science, history, and general culture of Anglo European societies. The study in higher apes of phenomena addressed by such concepts raises conceptual dilemmas, usually termed speciesism and anthropomorphism, not unlike those encountered in comparative human studies of similar phenomena across cultures and historical periods, namely, ethnocentrism and anachronism. The authors' synthesis of literature and their analysis of the implications of higher ape psychopathology represent an epistemically compelling account that broadens the scope of the comparative study of behavioral irregularities, a topic that provides a different slant for examining challenging questions in evolutionary biology and primatology, such as cognition, self awareness, intentional behavior, culture and behavioral traditions, social intelligence, sickness and healing, and altruism. Theoretical and empirical study of this topic expands formulation and can help provide informative answers about human evolution as well as essential features of human psychiatric syndromes, with potential practical implications. The study of psychopathology of higher apes and other non human primates represents an appropriate focus for neuroscience and bio-behavioral sciences.

UNDERSTANDING X-RAY STARS:. The Discovery of Binary X-ray Sources

NASA Astrophysics Data System (ADS)

Schreier, E. J.; Tananbaum, H.

2000-09-01

The discovery of binary X-ray sources with UHURU introduced many new concepts to astronomy. It provided the canonical model which explained X-ray emission from a large class of galactic X-ray sources: it confirmed the existence of collapsed objects as the source of intense X-ray emission; showed that such collapsed objects existed in binary systems, with mass accretion as the energy source for the X-ray emission; and provided compelling evidence for the existence of black holes. This model also provided the basis for explaining the power source of AGNs and QSOs. The process of discovery and interpretation also established X-ray astronomy as an essential sub-discipline of astronomy, beginning its incorporation into the mainstream of astronomy.

A Marine Origin for the Meridiani Planum Landing Site?

NASA Technical Reports Server (NTRS)

Parker, T. J.; Haldemann, A. F.

2005-01-01

The Opportunity instruments have provided compelling evidence that the sulfate-rich chemical and siliciclastic sediments at the Meridiani Planum landing site were deposited in shallow water. The local paleo-environment is most often characterized as a broad, shallow sea or large playa, with surface conditions cycling between wet and dry episodes, interbedding evaporates with eolian fine sediments [e.g., 1,2]. This particular working hypothesis is reasonable, considering the area characterized by the rover s mobility. An alternative, marine origin will be considered here, a working hypothesis that we feel provides a better fit to the local-scale results identified by Opportunity, and the regional-scale characteristics of Meridiani Planum provided by data from orbiting spacecraft, when considered together.

Ecological restoration should be redefined for the twenty-first century.

PubMed

Martin, David M

2017-09-24

Forty years ago, ecological restoration was conceptualized through a natural science lens. Today, ecological restoration has evolved into a social and scientific concept. The duality of ecological restoration is acknowledged in guidance documents on the subject but is not apparent in its definition. Current definitions reflect our views about what ecological restoration does but not why we do it. This viewpoint does not give appropriate credit to contributions from social sciences, nor does it provide compelling goals for people with different motivating rationales to engage in or support restoration. In this study, I give a concise history of the conceptualization and definition of ecological restoration, and I propose an alternative definition and corresponding viewpoint on restoration goal-setting to meet twenty-first century scientific and public inquiry.

Exobiological Exploration of Europa (E3) Europa Lander

NASA Technical Reports Server (NTRS)

Stillwagen, F. H.; Manvi, Ramachandra; Seywald, Hans; Park, Sang-Young; Kolacinski, Rick

2002-01-01

The search for life outside Earth's protected atmosphere is a compelling testament to the quest by mankind to determine if "we" are alone in the universe. The phenomenal success of the NASA Galileo spacecraft has indicated that the moons of Jupiter, and most notably Europa, may indeed contain subsurface liquid under an icy surface. This speculation of a salty liquid subsurface fuels expert opinions that biological products may exist. The Revolutionary Aerospace Systems Concepts (RASC) effort at Langley Research Center, initiated by NASA Headquarters, pushes NASA and the Aerospace/Science community to target advanced evolutionary technology usage to provide a Europa Lander concept targeted for completion within the next 50 years. The study effort indicates the use of certain advanced technologies to achieve a subsurface penetrator and liquid explorer in the approximately 2040 timeframe.

Skeletal Muscle Hypertrophy with Concurrent Exercise Training: Contrary Evidence for an Interference Effect.

PubMed

Murach, Kevin A; Bagley, James R

2016-08-01

Over the last 30+ years, it has become axiomatic that performing aerobic exercise within the same training program as resistance exercise (termed concurrent exercise training) interferes with the hypertrophic adaptations associated with resistance exercise training. However, a close examination of the literature reveals that the interference effect of concurrent exercise training on muscle growth in humans is not as compelling as previously thought. Moreover, recent studies show that, under certain conditions, concurrent exercise may augment resistance exercise-induced hypertrophy in healthy human skeletal muscle. The purpose of this article is to outline the contrary evidence for an acute and chronic interference effect of concurrent exercise on skeletal muscle growth in humans and provide practical literature-based recommendations for maximizing hypertrophy when training concurrently.

Fractal growth of platinum electrodeposits revealed by in situ electron microscopy.

PubMed

Wang, Lifen; Wen, Jianguo; Sheng, Huaping; Miller, Dean J

2016-10-06

Fractals are commonly observed in nature and elucidating the mechanisms of fractal-related growth is a compelling issue for both fundamental science and technology. Here we report an in situ electron microscopy study of dynamic fractal growth of platinum during electrodeposition in a miniaturized electrochemical cell at varying growth conditions. Highly dendritic growth - either dense branching or ramified islands - are formed at the solid-electrolyte interface. We show how the diffusion length of ions in the electrolyte influences morphology selection and how instability induced by initial surface roughness, combined with local enhancement of electric field, gives rise to non-uniform branched deposition as a result of nucleation/growth at preferred locations. Comparing the growth behavior under these different conditions provides new insight into the fundamental mechanisms of platinum nucleation.

Magnetospheric Multiscale (MMS)

NASA Image and Video Library

2014-05-09

Observatory #1 is shown here on the Ransome table, tilted in a vertical position to provide better access for the engineers and technicians. Learn more about MMS at www.nasa.gov/mms Credit NASA/Goddard The Magnetospheric Multiscale, or MMS, will study how the sun and the Earth's magnetic fields connect and disconnect, an explosive process that can accelerate particles through space to nearly the speed of light. This process is called magnetic reconnection and can occur throughout all space. NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

White-tailed deer age ratios as herd management and predator impact measures in Pennsylvania

USGS Publications Warehouse

Rosenberry, Christopher S.; Norton, Andrew S.; Diefenbach, Duane R.; Fleegle, Jeannine T.; Wallingford, Bret D.

2011-01-01

A review of the Pennsylvania Game Commission's (PGC) deer management program and public concern about predator impacts on deer (Odocoileus virginianus) populations compelled the PGC to investigate the role of age ratios in developing management recommendations. Age ratios, such as proportion of juveniles in the antlerless harvest, may provide an index to population productivity and predator impacts. We estimated proportion of juveniles in the antlerless harvest from hunter-killed deer, population trends using the Pennsylvania (USA) sex–age–kill model, and reproduction from road-killed females. Using these estimates and a simulation model, we concluded that no single age-ratio value would serve as a reliable measure of population status. Wildlife Management Unit-specific trends in proportion of juveniles in the antlerless harvest and population trends provided the most relevant management information. We also provide an example decision chart to guide management actions in response to declining age ratios in the harvest. Although predator management activities and juvenile survival studies are often desired by the public, our decision-chart example indicated a number of deer management options exist before investing resources in predator management activities and juvenile survival studies.

Compelled to Act: The Negotiation of Compassion Fatigue among Student Affairs Professionals

ERIC Educational Resources Information Center

Stoves, Douglas R.

2014-01-01

The purpose of the qualitative study was to identify the ways in which Student Affairs professionals in higher education in South Texas experienced and negotiated compassion fatigue through their everyday responsibilities. Research questions explored the development and experience of, and coping with, compassion fatigue. Grounded in Constructivist…

Burdened Children: Theory, Research, and Treatment of Parentification.

ERIC Educational Resources Information Center

Chase, Nancy D., Ed.

Parentification is defined as compelling children to perform the role of parent at the expense of their own developmentally appropriate needs and pursuits. This book presents a comprehensive study of parentification in the family, covering both theoretical and clinical topics. Part 1 of the book details research related to parentification and…

Asian American Youth Language Use: Perspectives across Schools and Communities

ERIC Educational Resources Information Center

Shankar, Shalini

2011-01-01

Recent studies of Asian American youth language practices have presented compelling insights about the identities and migration experiences of young people of Asian descent. This article offers a detailed examination of the relationship between language use and select issues concerning Asian American youth, including social life, schooling,…

Future Search in School District Change: Connection, Community, and Results

ERIC Educational Resources Information Center

Schweitz, Rita; Martens, Kim; Aronson, Nancy; Weisbord, Marvin; Janoff, Sandra

2005-01-01

This book contains sixteen compelling case studies that illustrate the power of future search to create lasting, whole system change. Future Search in School District Change: Connection, Community, and Results chronicles ways in which educational institutions have used broad-based stakeholder involvement to improve education. These experiences, by…

The Spatial-Numerical Congruity Effect in Preschoolers

ERIC Educational Resources Information Center

Patro, Katarzyna; Haman, Maciej

2012-01-01

Number-to-space mapping and its directionality are compelling topics in the study of numerical cognition. Usually, literacy and math education are thought to shape a left-to-right number line. We challenged this claim by analyzing performance of preliterate precounting preschoolers in a spatial-numerical task. In our experiment, children exhibited…

Counseling Psychology Trainees' Social Justice Interest and Commitment

ERIC Educational Resources Information Center

Miller, Matthew J.; Sendrowitz, Kerrin

2011-01-01

Scholars within the field of counseling psychology have for some time now articulated eloquent and compelling calls for attending to social justice in the social sciences. To date, counseling psychologists have been at the forefront of addressing social justice issues in research, practice, and professional development. The present study advances…

Virtual Learning: Is It Conducive to Student Achievement?

ERIC Educational Resources Information Center

Torain, Janie Mae Sheeley Johnson

2009-01-01

The use of technology to compel student learning has become an increasingly central component of teaching, learning, and school improvement efforts. What exactly does virtual learning entail? How does it integrate with curriculum and instruction? Does it present organizational challenges to educational institutions? This study examined unit test…

Conceptualizing Community Engagement: Starting a Campus-Wide Dialogue

ERIC Educational Resources Information Center

Starke, Anthony M., Jr.; Shenouda, Keristiena; Smith-Howell, Deborah

2017-01-01

Institutions of higher education are increasingly compelled to produce evidence that illustrates their contribution to society. In this age of demonstrating value, self-assessment is critical for urban and metropolitan universities. This study will explore the design and implementation of a landscape analysis--phase one of an in-depth…

The Impact of No Child Left Behind on Student Achievement

ERIC Educational Resources Information Center

Dee, Thomas S.; Jacob, Brian

2011-01-01

The No Child Left Behind (NCLB) Act compelled states to design school accountability systems based on annual student assessments. The effect of this federal legislation on the distribution of student achievement is a highly controversial but centrally important question. This study presents evidence on whether NCLB has influenced student…

Wellness Matters

ERIC Educational Resources Information Center

Arteaga, Brenda

2011-01-01

Creating a healthier school in today's world of budget cuts and seemingly endless to-do lists is not only possible, but it is also imperative. Beyond the health implications, one of the most compelling reasons for creating healthier schools is that wellness serves as a power booster for learning. Numerous studies have documented what educators…

On the Importance of Coherence in the Study of Character Development

ERIC Educational Resources Information Center

Callina, Kristina Schmid; Lerner, Richard M.

2017-01-01

Nucci (this issue) gives a compelling conceptualization of the ideas needed to understand character as a multifaceted developmental system. In this article, we focus on the idea of coherence as it applies to understanding character development, education, and assessment. Using ideas from relational developmental systems (RDS) metatheory, we…

Medication Administration: Measuring Associate Degree Nursing Student Knowledge

ERIC Educational Resources Information Center

Crowell, Debra L.

2016-01-01

The American Nurse Association's (ANA) provisions outline the commitment expected of nurses to protect the community from harm. Medication administration coincides with patient safety as a compelling obligation in nursing practice. The study's purpose was to examine retention of medication safety knowledge among first year nursing students, after…

Engagement with Young Adult Literature: Outcomes and Processes

ERIC Educational Resources Information Center

Ivey, Gay; Johnston, Peter H.

2013-01-01

This study examines students' perceptions of the outcomes and processes of engaged reading in classrooms prioritizing engagement through self-selected, self-paced reading of compelling young adult literature. The primary data were 71 end-of-year student interviews, supported by end-of-year teacher interviews, biweekly observational data,…

The Challenge of Assessing Project-Based Learning

ERIC Educational Resources Information Center

Boss, Suzie

2012-01-01

For their ambitious project, called America at War, high school juniors at Da Vinci Charter Academy in the Davis (California) Joint Unified School District didn't just study history. They became historians. Their project offers compelling evidence of what students can accomplish through project-based learning (PBL), an instructional approach that…

Faculty Technology Adoption and Integration: Motivations and Consequences

ERIC Educational Resources Information Center

Mrabet, Khalid

2009-01-01

In recent years, technology integration has become one of the top priorities at higher education institutions. Consequently, faculty members found themselves compelled to integrate computers and other technology into their teaching, research, and public service. The purpose of this qualitative study was to gain an understanding of some of the…

Brazilian and Nigerian International Students' Conceptions of Learning in Higher Education

ERIC Educational Resources Information Center

Ashong, Carol; Commander, Nannette

2017-01-01

The growth of international students compels examination of introspective aspects of learning experiences such as conceptions of learning. Additionally, learning conceptions profoundly impact learning outcomes (Tsai, 2009). To address the lack of research on learning conceptions of students from Africa and South America, this study examines…

Affordance of English-Medium Instruction Contexts in Taiwan

ERIC Educational Resources Information Center

Huang, Yi-Ping; Jhuang, Wun-Ting

2015-01-01

The proliferation of English-medium instruction (EMI) in nonnative English-speaking (NNES) contexts has compelled researchers to explore the challenges students face in such environments. Mostly quantitative in nature with foci on language-related difficulties in one type of institution or curriculum, these studies obscure the complexity of NNES…

Family Stress and Coping for Mexican Origin Adolescents

ERIC Educational Resources Information Center

Liu, Freda F.; Gonzales, Nancy A.; Fernandez, Aida Cristina; Millsap, Roger E.; Dumka, Larry E.

2011-01-01

Family-related stressors pose special challenges for adolescents of Mexican origin, given traditional cultural norms that compel youths to get involved with family problems despite their limited ability to effect change. The current study examines the prospective effects of coping strategies (i.e., active, distraction, avoidance, support-seeking,…

The dark side of gloss.

PubMed

Kim, Juno; Marlow, Phillip J; Anderson, Barton L

2012-11-01

Our visual system relies on the image structure generated by the interaction of light with objects to infer their material properties. One widely studied surface property is gloss, which can provide information that an object is smooth, shiny or wet. Studies have historically focused on the role of specular highlights in modulating perceived gloss. Here we show in human observers that glossy surfaces can generate both bright specular highlights and dark specular 'lowlights', and that the presence of either is sufficient to generate compelling percepts of gloss. We show that perceived gloss declines when the image structure generated by specular lowlights is blurred or misaligned with surrounding surface shading and that perceived gloss can arise from the presence of lowlights in surface regions isolated from highlights. These results suggest that the image structure generated by specular highlights and lowlights is used to construct our experience of surface gloss.

Online and Offline Performance Gains Following Motor Imagery Practice: A Comprehensive Review of Behavioral and Neuroimaging Studies.

PubMed

Di Rienzo, Franck; Debarnot, Ursula; Daligault, Sébastien; Saruco, Elodie; Delpuech, Claude; Doyon, Julien; Collet, Christian; Guillot, Aymeric

2016-01-01

There is now compelling evidence that motor imagery (MI) promotes motor learning. While MI has been shown to influence the early stages of the learning process, recent data revealed that sleep also contributes to the consolidation of the memory trace. How such "online" and "offline" processes take place and how they interact to impact the neural underpinnings of movements has received little attention. The aim of the present review is twofold: (i) providing an overview of recent applied and fundamental studies investigating the effects of MI practice (MIP) on motor learning; and (ii) detangling applied and fundamental findings in support of a sleep contribution to motor consolidation after MIP. We conclude with an integrative approach of online and offline learning resulting from intense MIP in healthy participants, and underline research avenues in the motor learning/clinical domains.

A qualitative study of programs for parents with serious mental illness and their children: building practice-based evidence.

PubMed

Nicholson, Joanne; Hinden, Beth R; Biebel, Kathleen; Henry, Alexis D; Katz-Leavy, Judith

2007-10-01

The rationale for the development of effective programs for parents with serious mental illness and their children is compelling. Using qualitative methods and a grounded theory approach with data obtained in site visits, seven existing programs for parents with mental illness and their children in the United States are described and compared across core components: target population, theory and assumptions, funding, community and agency contexts, essential services and intervention strategies, moderators, and outcomes. The diversity across programs is strongly complemented by shared characteristics, the identification of which provides the foundation for future testing and the development of an evidence base. Challenges in program implementation and sustainability are identified. Qualitative methods are useful, particularly when studying existing programs, in taking steps toward building the evidence base for effective programs for parents with serious mental illness and their children.

Space-based Remote Sensing: A Tool for Studying Bird Migration Across Multiple Scales

NASA Technical Reports Server (NTRS)

Smith, James A.

2005-01-01

The study of bird migration on a global scale is one of the compelling and challenging problems of modern biology with major implications for human health and conservation biology. Migration and conservation efforts cross national boundaries and are subject to numerous international agreements and treaties. Space based technology offers new opportunities to shed understanding on the distribution and migration of organisms on the planet and their sensitivity to human disturbances and environmental changes. Our working hypothesis is that individual organism biophysical models of energy and water balance, driven by satellite measurements of spatio-temporal gradients in climate and habitat, will help us to explain the variability in avian species richness and distribution. Further, these models provide an ecological forecasting tool for science and application users to visualize the possible consequences of loss of wetlands, flooding, or other natural disasters such as hurricanes on avian biodiversity and bird migration.

A mechanistical study on non-equilibrium reaction pathways in solid nitromethane (CH3NO2) and D3-nitromethane (CD3NO2) upon interaction with ionizing radiation

NASA Astrophysics Data System (ADS)

Kaiser, Ralf I.; Maksyutenko, Pavlo

2015-07-01

Thin films of homogeneously mixed nitromethane (CH3NO2) and D3-nitromethane (CD3NO2) ices were exposed to energetic electrons and Lyman α photons. The isotopically mixed reaction products were probed in situ via reflectron time-of-flight mass spectrometry coupled with pulsed photoionization during temperature programmed desorption. This study provides compelling evidence on three high energy pathways, which have not been observed under collisionless conditions in the gas phase. These are decomposition of nitromethane (CH3NO2) via atomic oxygen loss to nitrosomethane (CH3NO), fragmentation of nitromethane (CH3NO2) and/or methylnitrite (CH3ONO) via carbene (CH2) loss, and carbonsbnd hydrogen bond rupture processes in nitromethane (CH3NO2) and/or methylnitrite (CH3ONO).

Autonomy and paternalism in medical e-commerce.

PubMed

Mendoza, Roger Lee

2015-08-01

One of the overriding interests of the literature on health care economics is to discover where personal choice in market economies end and corrective government intervention should begin. Our study addresses this question in the context of John Stuart Mill's utilitarian principle of harm. Our primary objective is to determine whether public policy interventions concerning more than 35,000 online pharmacies worldwide are necessary and efficient compared to traditional market-oriented approaches. Secondly, we seek to determine whether government interference could enhance personal  utility maximization, despite its direct and indirect (unintended) costs on medical e-commerce. This study finds that containing the negative externalities of medical e-commerce provides the most compelling raison d'etre of government interference. It asserts that autonomy and paternalism need not be mutually exclusive, despite their direct and indirect consequences on individual choice and decision-making processes. Valuable insights derived from Mill's principle should enrich theory-building in health care economics and policy.

Online and Offline Performance Gains Following Motor Imagery Practice: A Comprehensive Review of Behavioral and Neuroimaging Studies

PubMed Central

Di Rienzo, Franck; Debarnot, Ursula; Daligault, Sébastien; Saruco, Elodie; Delpuech, Claude; Doyon, Julien; Collet, Christian; Guillot, Aymeric

2016-01-01

There is now compelling evidence that motor imagery (MI) promotes motor learning. While MI has been shown to influence the early stages of the learning process, recent data revealed that sleep also contributes to the consolidation of the memory trace. How such “online” and “offline” processes take place and how they interact to impact the neural underpinnings of movements has received little attention. The aim of the present review is twofold: (i) providing an overview of recent applied and fundamental studies investigating the effects of MI practice (MIP) on motor learning; and (ii) detangling applied and fundamental findings in support of a sleep contribution to motor consolidation after MIP. We conclude with an integrative approach of online and offline learning resulting from intense MIP in healthy participants, and underline research avenues in the motor learning/clinical domains. PMID:27445755

Restoration of fMRI Decodability Does Not Imply Latent Working Memory States

PubMed Central

Schneegans, Sebastian; Bays, Paul M.

2018-01-01

Recent imaging studies have challenged the prevailing view that working memory is mediated by sustained neural activity. Using machine learning methods to reconstruct memory content, these studies found that previously diminished representations can be restored by retrospective cueing or other forms of stimulation. These findings have been interpreted as evidence for an activity-silent working memory state that can be reactivated dependent on task demands. Here, we test the validity of this conclusion by formulating a neural process model of working memory based on sustained activity and using this model to emulate a spatial recall task with retrocueing. The simulation reproduces both behavioral and fMRI results previously taken as evidence for latent states, in particular the restoration of spatial reconstruction quality following an informative cue. Our results demonstrate that recovery of the decodability of an imaging signal does not provide compelling evidence for an activity-silent working memory state. PMID:28820674

Ambulatory Assessment

PubMed Central

Trull, Timothy J.; Ebner-Priemer, Ulrich

2014-01-01

Ambulatory assessment (AA) covers a wide range of assessment methods to study people in their natural environment, including self-report, observational, and biological/physiological/behavioral. AA methods minimize retrospective biases while gathering ecologically valid data from patients’ everyday life in real time or near real time. Here, we report on the major characteristics of AA, and we provide examples of applications of AA in clinical psychology (a) to investigate mechanisms and dynamics of symptoms, (b) to predict the future recurrence or onset of symptoms, (c) to monitor treatment effects, (d) to predict treatment success, (e) to prevent relapse, and (f) as interventions. In addition, we present and discuss the most pressing and compelling future AA applications: technological developments (the smartphone), improved ecological validity of laboratory results by combined lab-field studies, and investigating gene-environment interactions. We conclude with a discussion of acceptability, compliance, privacy, and ethical issues. PMID:23157450

Does the evidence for an inverse relationship between serum vitamin D status and breast cancer risk satisfy the Hill criteria?

PubMed

Mohr, Sharif B; Gorham, Edward D; Alcaraz, John E; Kane, Christopher I; Macera, Caroline A; Parsons, J Kellogg; Wingard, Deborah L; Garland, Cedric F

2012-04-01

A wide range of epidemiologic and laboratory studies combined provide compelling evidence of a protective role of vitamin D on risk of breast cancer. This review evaluates the scientific evidence for such a role in the context of the A.B. Hill criteria for causality, in order to assess the presence of a causal, inverse relationship, between vitamin D status and breast cancer risk. After evaluation of this evidence in the context of Hill's criteria, it was found that the criteria for a causal relationship were largely satisfied. Studies in human populations and the laboratory have consistently demonstrated that vitamin D plays an important role in the prevention of breast cancer. Vitamin D supplementation is an urgently needed, low cost, effective, and safe intervention strategy for breast cancer prevention that should be implemented without delay. In the meantime, randomized controlled trials of high doses of vitamin D(3) for prevention of breast cancer should be undertaken to provide the necessary evidence to guide national health policy.

Thresholds in marsh resilience to the Deepwater Horizon oil spill

PubMed Central

Silliman, Brian R.; Dixon, Philip M.; Wobus, Cameron; He, Qiang; Daleo, Pedro; Hughes, Brent B.; Rissing, Matthew; Willis, Jonathan M.; Hester, Mark W.

2016-01-01

Ecosystem boundary retreat due to human-induced pressure is a generally observed phenomenon. However, studies that document thresholds beyond which internal resistance mechanisms are overwhelmed are uncommon. Following the Deepwater Horizon (DWH) oil spill, field studies from a few sites suggested that oiling of salt marshes could lead to a biogeomorphic feedback where plant death resulted in increased marsh erosion. We tested for spatial generality of and thresholds in this effect across 103 salt marsh sites spanning ~430 kilometers of shoreline in coastal Louisiana, Alabama, and Mississippi, using data collected as part of the natural resource damage assessment (NRDA). Our analyses revealed a threshold for oil impacts on marsh edge erosion, with higher erosion rates occurring for ~1–2 years after the spill at sites with the highest amounts of plant stem oiling (90–100%). These results provide compelling evidence showing large-scale ecosystem loss following the Deepwater Horizon oil spill. More broadly, these findings provide rare empirical evidence identifying a geomorphologic threshold in the resistance of an ecosystem to increasing intensity of human-induced disturbance. PMID:27679956

Concise Review: Mesenchymal Stromal Cell‐Based Approaches for the Treatment of Acute Respiratory Distress and Sepsis Syndromes

PubMed Central

Soeder, Yorick; Dahlke, Marc H.

2017-01-01

Abstract Despite extensive research on candidate pharmacological treatments and a significant and increasing prevalence, sepsis syndrome, and acute respiratory distress syndrome (ARDS) remain areas of unmet clinical need. Preclinical studies examining mesenchymal stromal cell (MSCs) based‐therapies have provided compelling evidence of potential benefit; however, the precise mechanism by which MSCs exert a therapeutic influence, and whether MSC application is efficacious in humans, remains unknown. Detailed evaluation of the limited number of human trials so far completed is further hampered as a result of variations in trial design and biomarker selection. This review provides a concise summary of current preclinical and clinical knowledge of MSCs as a cell therapy for sepsis syndrome and ARDS. The challenges of modeling such heterogeneous and rapidly progressive disease states are considered and we discuss how lessons from previous studies of pharmacological treatments for sepsis syndrome and ARDS might be used to inform and refine the design of the next generation of MSC clinical trials. Stem Cells Translational Medicine 2017;6:1141–1151 PMID:28186706

The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging.

PubMed

Karuppagounder, Vengadeshprabhu; Arumugam, Somasundaram; Babu, Sahana Suresh; Palaniyandi, Suresh S; Watanabe, Kenichi; Cooke, John P; Thandavarayan, Rajarajan A

2017-05-01

Because cardiovascular disease remains the major cause of mortality and morbidity world-wide, there remains a compelling need for new insights and novel therapeutic avenues. In this regard, the senescence-accelerated mouse prone 8 (SAMP8) line is a particularly good model for studying the effects of aging on cardiovascular health. Accumulating evidence suggests that this model may shed light on age-associated cardiac and vascular dysfunction and disease. These animals manifest evidence of inflammation, oxidative stress and adverse cardiac remodeling that may recapitulate processes involved in human disease. Early alterations in oxidative damage promote endoplasmic reticulum stress to trigger apoptosis and cytokine production in this genetically susceptible mouse strain. Conversely, pharmacological treatments that reduce inflammation and oxidative stress improve cardiac function in these animals. Therefore, the SAMP8 mouse model provides an exciting opportunity to expand our knowledge of aging in cardiovascular disease and the potential identification of novel targets of treatment. Herein, we review the previous studies performed in SAMP8 mice that provide insight into age-related cardiovascular alterations. Copyright © 2016 Elsevier B.V. All rights reserved.

Evolution of a Materials Data Infrastructure

NASA Astrophysics Data System (ADS)

Warren, James A.; Ward, Charles H.

2018-06-01

The field of materials science and engineering is writing a new chapter in its evolution, one of digitally empowered materials discovery, development, and deployment. The 2008 Integrated Computational Materials Engineering (ICME) study report helped usher in this paradigm shift, making a compelling case and strong recommendations for an infrastructure supporting ICME that would enable access to precompetitive materials data for both scientific and engineering applications. With the launch of the Materials Genome Initiative in 2011, which drew substantial inspiration from the ICME study, digital data was highlighted as a core component of a Materials Innovation Infrastructure, along with experimental and computational tools. Over the past 10 years, our understanding of what it takes to provide accessible materials data has matured and rapid progress has been made in establishing a Materials Data Infrastructure (MDI). We are learning that the MDI is essential to eliminating the seams between experiment and computation by providing a means for them to connect effortlessly. Additionally, the MDI is becoming an enabler, allowing materials engineering to tie into a much broader model-based engineering enterprise for product design.

Culturally compelling strategies for behaviour change: a social ecology model and case study in malaria prevention.

PubMed

Panter-Brick, Catherine; Clarke, Sian E; Lomas, Heather; Pinder, Margaret; Lindsay, Steve W

2006-06-01

Behaviour change is notoriously difficult to initiate and sustain, and the reasons why efforts to promote healthy behaviours fail are coming under increasing scrutiny. To be successful, health interventions should build on existing practices, skills and priorities, recognise the constraints on human behaviour, and either feature community mobilisation or target those most receptive to change. Furthermore, interventions should strive to be culturally compelling, not merely culturally appropriate: they must engage local communities and nestle within social and ecological landscapes. In this paper, we propose a social ecology perspective to make explicit the links between intention to change, actual behaviour change, and subsequent health impact, as relating to both theory-based models and practical strategies for triggering behaviour change. A social ecology model focuses attention on the contexts of behaviour when designing, implementing or critically evaluating interventions. As a case study, we reflect on a community-directed intervention in rural Gambia designed to reduce malaria by promoting a relatively simple and low-cost behaviour: repairing holes in mosquito bednets. In phase 1, contextual information on bednet usage, transactions and repairs (the 'social lives' of nets) was documented. In phase 2 (intervention), songs were composed and posters displayed by community members to encourage repairs, creating a sense of ownership and a compelling medium for the transmission of health messages. In phase 3 (evaluation), qualitative and quantitative data showed that household responses were particularly rapid and extensive, with significant increase in bednet repairs (p<0.001), despite considerable constraints on human agency. We highlight a promising approach-using songs-as a vehicle for change, and present a framework to embed the design, implementation and critical evaluation of interventions within the larger context-or social ecology-of behaviour practices that are the bedrock of health interventions.

Authoring Tours of Geospatial Data With KML and Google Earth

NASA Astrophysics Data System (ADS)

Barcay, D. P.; Weiss-Malik, M.

2008-12-01

As virtual globes become widely adopted by the general public, the use of geospatial data has expanded greatly. With the popularization of Google Earth and other platforms, GIS systems have become virtual reality platforms. Using these platforms, a casual user can easily explore the world, browse massive data-sets, create powerful 3D visualizations, and share those visualizations with millions of people using the KML language. This technology has raised the bar for professionals and academics alike. It is now expected that studies and projects will be accompanied by compelling, high-quality visualizations. In this new landscape, a presentation of geospatial data can be the most effective form of advertisement for a project: engaging both the general public and the scientific community in a unified interactive experience. On the other hand, merely dumping a dataset into a virtual globe can be a disorienting, alienating experience for many users. To create an effective, far-reaching presentation, an author must take care to make their data approachable to a wide variety of users with varying knowledge of the subject matter, expertise in virtual globes, and attention spans. To that end, we present techniques for creating self-guided interactive tours of data represented in KML and visualized in Google Earth. Using these methods, we provide the ability to move the camera through the world while dynamically varying the content, style, and visibility of the displayed data. Such tours can automatically guide users through massive, complex datasets: engaging a broad user-base, and conveying subtle concepts that aren't immediately apparent when viewing the raw data. To the casual user these techniques result in an extremely compelling experience similar to watching video. Unlike video though, these techniques maintain the rich interactive environment provided by the virtual globe, allowing users to explore the data in detail and to add other data sources to the presentation.

Effects of an International Experience Requirement, Year in School, and Preferred Program Duration on Student Interest in Study Abroad

ERIC Educational Resources Information Center

Richart, Adrienne F.

2015-01-01

Several compelling rationales have driven dramatic increases in the number of students that U.S. American postsecondary institutions send abroad each year. The rationales are political, academic, cultural/social, and economic in nature and undeniably integral to developing graduates who are prepared to compete in the global arena. This study was…

Exercise and Diabetes: A Narrative Review.

PubMed

Jenkins, David W; Jenks, Alexander

Persons with diabetes might experience significant benefits through regular exercise. Not unlike the general population, those with diabetes could also lack motivation to participate in an exercise program. Often, those treating persons with diabetes lack training and/or interest in exercise prescription and are therefore unable to provide the needed information and encouragement. In many cases, reluctance to exercise could result from an inability to find an enjoyable exercise activity. Attempts to find activities that, not only provide effective aerobic challenges, but are also enjoyable to participate in are fraught with difficulty. Three electronic databases were searched in January 2017. Evidence for the merits of exercise for those with diabetes was robust. Numerous reports have addressed the degree of noncompliance to exercise recommendations and the barriers reported for this nonadherence. Additional studies concluded that most medical providers are deficient in formal training in the prescription of an exercise program. Newer studies are evaluating the effects of exercise and vitamin D supplementation and their interplay with diabetic peripheral neuropathy and ulceration. Exercise confers remarkable benefits to those with diabetes; however, the challenges to compelling patients with diabetes to exercise are formidable. An improved focus on exercise prescription and related motivation during provider training must be undertaken. Copyright © 2017 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

An integrated pipeline to create and experience compelling scenarios in virtual reality

NASA Astrophysics Data System (ADS)

Springer, Jan P.; Neumann, Carsten; Reiners, Dirk; Cruz-Neira, Carolina

2011-03-01

One of the main barriers to create and use compelling scenarios in virtual reality is the complexity and time-consuming efforts for modeling, element integration, and the software development to properly display and interact with the content in the available systems. Still today, most virtual reality applications are tedious to create and they are hard-wired to the specific display and interaction system available to the developers when creating the application. Furthermore, it is not possible to alter the content or the dynamics of the content once the application has been created. We present our research on designing a software pipeline that enables the creation of compelling scenarios with a fair degree of visual and interaction complexity in a semi-automated way. Specifically, we are targeting drivable urban scenarios, ranging from large cities to sparsely populated rural areas that incorporate both static components (e. g., houses, trees) and dynamic components (e. g., people, vehicles) as well as events, such as explosions or ambient noise. Our pipeline has four basic components. First, an environment designer, where users sketch the overall layout of the scenario, and an automated method constructs the 3D environment from the information in the sketch. Second, a scenario editor used for authoring the complete scenario, incorporate the dynamic elements and events, fine tune the automatically generated environment, define the execution conditions of the scenario, and set up any data gathering that may be necessary during the execution of the scenario. Third, a run-time environment for different virtual-reality systems provides users with the interactive experience as designed with the designer and the editor. And fourth, a bi-directional monitoring system that allows for capturing and modification of information from the virtual environment. One of the interesting capabilities of our pipeline is that scenarios can be built and modified on-the-fly as they are being presented in the virtual-reality systems. Users can quickly prototype the basic scene using the designer and the editor on a control workstation. More elements can then be introduced into the scene from both the editor and the virtual-reality display. In this manner, users are able to gradually increase the complexity of the scenario with immediate feedback. The main use of this pipeline is the rapid development of scenarios for human-factors studies. However, it is applicable in a much more general context.

Healthcare Providers' Formative Experiences with Race and Black Male Patients in Urban Hospital Environments.

PubMed

Plaisime, Marie V; Malebranche, David J; Davis, Andrea L; Taylor, Jennifer A

2017-12-01

We explored health providers' formative personal and professional experiences with race and Black men as a way to assess their potential influence on interactions with Black male patients. Utilizing convenience sampling with snowballing techniques, we identified healthcare providers in two urban university hospitals. We compared Black and White providers' experiences based on race and level of training. We used the Gardener's Tale to conceptualize how racism may lead to racial health disparities. A semi-structured interview guide was used to conduct in-person interviews (n = 16). Using the grounded theory approach, we conducted three types of coding to examine data patterns. We found two themes reflective of personally mediated racism: (1) perception of Black males accompanied by two subthemes (a) biased care and (b) fear and discomfort and (2) cognitive dissonance. While this latter theme is more reflective of Jones's internalized racism level, we present its results because its novelty is compelling. Perception of Black males and cognitive dissonance appear to influence providers' approaches with Black male patients. This study suggests the need to develop initiatives and curricula in health professional schools that address provider racial bias. Understanding the dynamics operating in the patient-provider encounter enhances the ability to address and reduce health disparities.

Robot-like dexterity without computers and motors: a review of hand-held laparoscopic instruments with wrist-like tip articulation

PubMed Central

Anderson, Patrick L.; Lathrop, Ray A.; Webster, Robert J.

2018-01-01

Introduction Conventional manual laparoscopic instruments for minimally invasive surgery have limited dexterity within the patient, making procedures challenging. Surgical robotic systems offer enhanced articulation, but at substantial financial costs. This has motivated the development of high-dexterity, low-cost laparoscopic instruments. Areas covered This article reviews both commercial and academic results on creating fully mechanical (i.e. non-robotic) laparoscopic instruments that provide wrists or wrist-like dexterity within the patient. We review the state of the art in the development of these mechanical instruments, focusing on the surgeon interface, wrist mechanism, and the kinematic mapping between the two. Expert commentary Current articulated mechanical laparoscopic instruments exhibit a wide range of designs, with no clear consensus on what makes such devices easy to use. As these technologies mature, user studies are needed to determine surgeon preferences. Articulated, low-cost instruments have the potential to impact the minimally invasive surgery market if they provide compelling benefits to surgeons. PMID:26808896

Kinematic Treatment of CME Evolution in the Solar Wind

NASA Technical Reports Server (NTRS)

Riley, Pete; Crooker, N. U.

2004-01-01

We present a kinematic study of the evolution of coronal mass ejections (CMEs) in the solar wind. Specifically, we consider the effects of: (1) spherical expansion; and (2) uniform expansion due to pressure gradients between the Interplanetary CME (ICME) and the ambient solar wind. We compare these results with an MHD model, which allows us to isolate these effects from the combined kinematic and dynamical effects, which are included in MHD models. They also provide compelling evidence that the fundamental cross section of so-called "force-free" flux ropes (or magnetic clouds) is neither circular or elliptical, but rather a convex-outward, "pancake" shape. We apply a force-free fitting to the magnetic vectors from the MHD simulation to assess how the distortion of the flux rope affects the fitting. In spite of these limitations, force-free fittings, which are straightforward to apply, do provide an important description of a number of parameters, including the radial dimension, orientation and chirality of the ICME.

Effect of hydrogen on deformation structure and properties of CMSX-2 nickel-base single-crystal superalloy

NASA Technical Reports Server (NTRS)

Dollar, M.; Bernstein, I. M.; Walston, S.; Prinz, F.; Domnanovich, A.

1987-01-01

Material used in this study was a heat of the alloy CMSX-2. This nickel-based superalloy was provided in the form of oriented single crystals, solutionized for 3 hrs at 1315 C. It was then usually heat treated as follows: 1050 C/16h/air cool + 850 C/48h/air cool. The resulting microstructure is dominated by cuboidal, ordered gamma precipitates with a volume fraction of about 75% and an average size of 0.5 microns. In brief, the most compelling hydrogen induced-changes in deformation structure are: (1) enhanced dislocation accumulation in the gamma matrix; and (2) more extensive cross-slip of superdislocations in the gamma precipitates. The enhanced dislocation density in gamma acts to decrease the mean free path of a superdislocation, while easier cross slip hinders superdislocation movement by providing pinning points in the form of sessile jobs. Both processes contribute to the increase of flow stress and the notable work hardening that occurs prior to fracture.

The organization of prospective thinking: evidence of event clusters in freely generated future thoughts.

PubMed

Demblon, Julie; D'Argembeau, Arnaud

2014-02-01

Recent research suggests that many imagined future events are not represented in isolation, but instead are embedded in broader event sequences-referred to as event clusters. It remains unclear, however, whether the production of event clusters reflects the underlying organizational structure of prospective thinking or whether it is an artifact of the event-cuing task in which participants are explicitly required to provide chains of associated future events. To address this issue, the present study examined whether the occurrence of event clusters in prospective thought is apparent when people are left to think freely about events that might happen in their personal future. The results showed that the succession of events participants spontaneously produced when envisioning their future frequently included event clusters. This finding provides more compelling evidence that prospective thinking involves higher-order autobiographical knowledge structures that organize imagined events in coherent themes and sequences. Copyright © 2014 Elsevier Inc. All rights reserved.

Creating wavelet-based models for real-time synthesis of perceptually convincing environmental sounds

NASA Astrophysics Data System (ADS)

Miner, Nadine Elizabeth

1998-09-01

This dissertation presents a new wavelet-based method for synthesizing perceptually convincing, dynamic sounds using parameterized sound models. The sound synthesis method is applicable to a variety of applications including Virtual Reality (VR), multi-media, entertainment, and the World Wide Web (WWW). A unique contribution of this research is the modeling of the stochastic, or non-pitched, sound components. This stochastic-based modeling approach leads to perceptually compelling sound synthesis. Two preliminary studies conducted provide data on multi-sensory interaction and audio-visual synchronization timing. These results contributed to the design of the new sound synthesis method. The method uses a four-phase development process, including analysis, parameterization, synthesis and validation, to create the wavelet-based sound models. A patent is pending for this dynamic sound synthesis method, which provides perceptually-realistic, real-time sound generation. This dissertation also presents a battery of perceptual experiments developed to verify the sound synthesis results. These experiments are applicable for validation of any sound synthesis technique.

Robot-like dexterity without computers and motors: a review of hand-held laparoscopic instruments with wrist-like tip articulation.

PubMed

Anderson, Patrick L; Lathrop, Ray A; Webster, Robert J

2016-07-01

Conventional manual laparoscopic instruments for minimally invasive surgery have limited dexterity within the patient, making procedures challenging. Surgical robotic systems offer enhanced articulation, but at substantial financial costs. This has motivated the development of high-dexterity, low-cost laparoscopic instruments. This article reviews both commercial and academic results on creating fully mechanical (i.e. non-robotic) laparoscopic instruments that provide wrists or wrist-like dexterity within the patient. We review the state of the art in the development of these mechanical instruments, focusing on the surgeon interface, wrist mechanism, and the kinematic mapping between the two. Expert commentary: Current articulated mechanical laparoscopic instruments exhibit a wide range of designs, with no clear consensus on what makes such devices easy to use. As these technologies mature, user studies are needed to determine surgeon preferences. Articulated, low-cost instruments have the potential to impact the minimally invasive surgery market if they provide compelling benefits to surgeons.

Investigating paranormal phenomena: Functional brain imaging of telepathy

PubMed Central

Venkatasubramanian, Ganesan; Jayakumar, Peruvumba N; Nagendra, Hongasandra R; Nagaraja, Dindagur; Deeptha, R; Gangadhar, Bangalore N

2008-01-01

Aim: “Telepathy” is defined as “the communication of impressions of any kind from one mind to another, independently of the recognized channels of sense”. Meta-analyses of “ganzfield” studies as well as “card-guessing task” studies provide compelling evidence for the existence of telepathic phenomena. The aim of this study was to elucidate the neural basis of telepathy by examining an individual with this special ability. Materials and Methods: Using functional MRI, we examined a famous “mentalist” while he was performing a telepathic task in a 1.5 T scanner. A matched control subject without this special ability was also examined under similar conditions. Results: The mentalist demonstrated significant activation of the right parahippocampal gyrus after successful performance of a telepathic task. The comparison subject, who did not show any telepathic ability, demonstrated significant activation of the left inferior frontal gyrus. Conclusions: The findings of this study are suggestive of a limbic basis for telepathy and warrant further systematic research. PMID:21829287

UV/Visible Telescope with Hubble Disposal

NASA Technical Reports Server (NTRS)

Benford, Dominic J.

2013-01-01

Submission Overview: Our primary objective is to convey a sense of the significant advances possible in astrophysics investigations for major Cosmic Origins COR program goals with a 2.4m telescope asset outfitted with one or more advanced UV visible instruments. Several compelling science objectives were identified based on community meetings these science objectives drove the conceptual design of instruments studied by the COR Program Office during July September 2012. This RFI submission encapsulates the results of that study, and suggests that a more detailed look into the instrument suite should be conducted to prove viability and affordability to support the demonstrated scientific value. This study was conducted in the context of a larger effort to consider the options available for a mission to dispose safely of Hubble hence, the overall architecture considered for the mission we studied for the 2.4m telescope asset included resource sharing. This mitigates combined cost and risk and provides naturally for a continued US leadership role in astrophysics with an advanced, general-purpose UV visible space telescope.

Increased hippocampal blood volume and normal blood flow in schizophrenia

PubMed Central

Talati, Pratik; Rane, Swati; Skinner, Jack; Gore, John; Heckers, Stephan

2015-01-01

Neuroimaging studies have provided compelling evidence for abnormal hippocampal activity in schizophrenia. Most studies made inferences about baseline hippocampal activity using a single hemodynamic parameter (e.g., blood volume or blood flow). Here we studied several hemodynamic measures in the same cohort to test the hypothesis of increased hippocampal activity in schizophrenia. We used dynamic susceptibility contrast- (DSC-) magnetic resonance imaging to assess blood volume, blood flow, and mean transit time in the hippocampus of 15 patients with chronic schizophrenia and 15 healthy controls. Left and right hippocampal measurements were combined for absolute measures of cerebral blood volume (CBV), blood flow (CBF), and mean transit time (MTT). We found significantly increased hippocampal CBV, but normal CBF and MTT, in schizophrenia. The uncoupling of CBV and CBF could be due to several factors, including antipsychotic medication, loss of cerebral perfusion pressure, or angiogenesis. Further studies need to incorporate several complementary imaging modalities to better characterize hippocampal dysfunction in schizophrenia. PMID:25896442

Modulation of the Gastrointestinal Microbiome with Nondigestible Fermentable Carbohydrates To Improve Human Health.

PubMed

Deehan, Edward C; Duar, Rebbeca M; Armet, Anissa M; Perez-Muñoz, Maria Elisa; Jin, Mingliang; Walter, Jens

2017-09-01

There is a clear association between the gastrointestinal (GI) microbiome and the development of chronic noncommunicable diseases, providing a rationale for the development of strategies that target the GI microbiota to improve human health. In this article, we discuss the potential of supplementing the human diet with nondigestible fermentable carbohydrates (NDFCs) to modulate the composition, structure, diversity, and metabolic potential of the GI microbiome in an attempt to prevent or treat human disease. The current concepts by which NDFCs can be administered to humans, including prebiotics, fermentable dietary fibers, and microbiota-accessible carbohydrates, as well as the mechanisms by which these carbohydrates exert their health benefits, are discussed. Epidemiological research presents compelling evidence for the health effects of NDFCs, with clinical studies providing further support for some of these benefits. However, rigorously designed human intervention studies with well-established clinical markers and microbial endpoints are still essential to establish (i) the clinical efficiency of specific NDFCs, (ii) the causal role of the GI microbiota in these effects, (iii) the underlying mechanisms involved, and (iv) the degree by which inter-individual differences between GI microbiomes influence these effects. Such studies would provide the mechanistic understanding needed for a systematic application of NDFCs to improve human health via GI microbiota modulation while also allowing the personalization of these dietary strategies.

The ethics of stem cells revisited.

PubMed

de Miguel-Beriain, Iñigo

2015-03-01

Stem cells constitute one of the most promising tools for regenerative medicine. Thus, it seems morally compelling to explore all the sources that might provide us with them. However, some of these sources, such as somatic cell nuclear transfer, embryo destruction, or even induced pluripotency obtained by reprogramming have raised deep ethical issues. The aim of this paper is to reflect on the stem cell ethical debate at the current moment through an analysis of the academic literature. It will also provide an analysis of the ethical implications of the most relevant scientific advances that have happened in recent months or those which seem about to merge. Copyright © 2014 Elsevier B.V. All rights reserved.

The Science in Science Fiction: Using Popular Entertainment as a Gateway

NASA Astrophysics Data System (ADS)

Basri, Gibor S.

2011-05-01

Science fiction on television and in movies reaches a wide audience of young people. Some of them are avid fans of particular stories, and more are enthralled by some of the special effects and other science fiction themes that have become ever more compelling as media technology improves. It actually doesn't matter whether the physics behind the science fiction is solid, the latest in speculative theory, or absolute nonsense - all provide a backdrop against which to present solid science. I'll talk about the opportunities provided by a few recent series and movies and how they can be woven into discussions of physics, astrophysics, or how science really works.

The application of volume-outcome contouring in data warehousing.

PubMed

Studnicki, James; Berndt, Donald J; Luther, Stephen L; Fisher, John W

2004-01-01

Despite a compelling body of published research on the nature of provider volume and clinical outcomes, healthcare executives and policymakers have not managed to develop and implement systems that are useful in directing patients to higher volume providers via selective referral or avoidance. A specialized data warehouse application, utilizing hospital discharge data linked to physician biographical information, allows detailed analysis of physician and hospital volume and the resulting pattern (contour) of related outcomes such as mortality, complications, and medical errors. The approach utilizes a historical repository of hospital discharge data in which the outcomes of interest, important patient characteristics and risk factors used in severity-adjusting of the outcomes are derived from the coding structure of the data.

Proceedings of Seminar (22nd) on Coastal and Inland Water Quality Held in Las Vegas, Nevada on 6-7 February 1990

DTIC Science & Technology

1990-05-01

mystic of biology and formal training compelled me to pursue aquatic biology as a career. I later learned to enjoy applied science and a teamwork...reviewing "Umnology" by Welch when he is struggling with a technical problem or a mental block. I strongly recommend this approach as therapy or a... aquatic environment. The 404(b)(1) guidelines at 40 CFR, Part 230, and ocean dumping criteria at 40 CFR, Part 220-228 provide general regulatory guidance

Excitonic AND Logic Gates on DNA Brick Nanobreadboards.

PubMed

Cannon, Brittany L; Kellis, Donald L; Davis, Paul H; Lee, Jeunghoon; Kuang, Wan; Hughes, William L; Graugnard, Elton; Yurke, Bernard; Knowlton, William B

2015-03-18

A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic devices. DNA brick assembly is a compelling method for creating programmable nanobreadboards on which chromophores may be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. Using DNA nanobreadboards, we have demonstrated each of these functions through the construction and operation of two different excitonic AND logic gates. The modularity and high chromophore density achievable via this brick-based approach provide a viable path toward developing information processing and storage systems.

Excitonic AND Logic Gates on DNA Brick Nanobreadboards

PubMed Central

2015-01-01

A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic devices. DNA brick assembly is a compelling method for creating programmable nanobreadboards on which chromophores may be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. Using DNA nanobreadboards, we have demonstrated each of these functions through the construction and operation of two different excitonic AND logic gates. The modularity and high chromophore density achievable via this brick-based approach provide a viable path toward developing information processing and storage systems. PMID:25839049

Report of the CIRRPC Executive Committee regarding EPA NESHAP regulations on radionuclides for medical research institutions and radiopharmaceutical manufacturers

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1990-06-01

There appears to be no compelling public health protection reason for EPA`s promulgation of NESHAP regulations to control air emissions of radioactive materials from NRC-licensed facilities engaged in activities associated with the practice and development of nuclear medicine. The NRC`s existing regulations provide the necessary controls for protection and EPA`s regulations would only add burdensome reporting requirements at substantial cost to medical treatment and diagnosis. Availability of nuclear medicine practice could be impacted and advancements through research delayed.

Abstraction and reformulation in artificial intelligence.

PubMed Central

Holte, Robert C.; Choueiry, Berthe Y.

2003-01-01

This paper contributes in two ways to the aims of this special issue on abstraction. The first is to show that there are compelling reasons motivating the use of abstraction in the purely computational realm of artificial intelligence. The second is to contribute to the overall discussion of the nature of abstraction by providing examples of the abstraction processes currently used in artificial intelligence. Although each type of abstraction is specific to a somewhat narrow context, it is hoped that collectively they illustrate the richness and variety of abstraction in its fullest sense. PMID:12903653

Abstraction and reformulation in artificial intelligence.

PubMed

Holte, Robert C; Choueiry, Berthe Y

2003-07-29

This paper contributes in two ways to the aims of this special issue on abstraction. The first is to show that there are compelling reasons motivating the use of abstraction in the purely computational realm of artificial intelligence. The second is to contribute to the overall discussion of the nature of abstraction by providing examples of the abstraction processes currently used in artificial intelligence. Although each type of abstraction is specific to a somewhat narrow context, it is hoped that collectively they illustrate the richness and variety of abstraction in its fullest sense.

Joe L. Kincheloe: Embracing criticality in science education

NASA Astrophysics Data System (ADS)

Bayne, Gillian U.

2009-09-01

This article reviews significant contributions made by Joe L. Kincheloe to critical research in science education, especially through a multimethodological, multitheoretical, and multidisciplinary informed lens that incorporates social, cultural, political, economic, and cognitive dynamics—the bricolage. Kincheloe's ideas provide for a compelling understanding of, and insights into, the forces that shape the intricacies of teaching and learning science and science education. They have implications in improving science education policies, in developing actions that challenge and cultivate the intellect while operating in ways that are more understanding of difference and are socially just.

Exchange-Dominated Pure Spin Current Transport in Alq3 Molecules.

PubMed

Jiang, S W; Liu, S; Wang, P; Luan, Z Z; Tao, X D; Ding, H F; Wu, D

2015-08-21

We address the controversy over the spin transport mechanism in Alq3 utilizing spin pumping in the Y3Fe5O12/Alq3/Pd system. An unusual angular dependence of the inverse spin Hall effect is found. It, however, disappears when the microwave magnetic field is fully in the sample plane, excluding the presence of the Hanle effect. Together with the quantitative temperature-dependent measurements, these results provide compelling evidence that the pure spin current transport in Alq3 is dominated by the exchange-mediated mechanism.

Shaking Up Biotech/Pharma: Can Cues Be Taken from the Tech Industry?

PubMed

Wang, C Katherine

2017-06-01

The biotech and pharma (biotech/pharma) industry is in dire need of finding ways to increase efficacy, efficiency, and affordability of its products. The information and technology industry ("tech") industry, which is an industry similarly founded on inventions and innovation, may provide some food for thought. This perspective will demonstrate the shift that biotech/pharma is already making and will propose that the industry has an opportunity to compel change by adopting some aspects of the tech industry with regards to models for technology/product development and leadership attributes.

Competitive Swimming and Racial Disparities in Drowning

PubMed Central

Myers, Samuel L.; Cuesta, Ana M.; Lai, Yufeng

2018-01-01

This paper provides compelling evidence of an inverse relationship between competitive swimming rates and drowning rates using Centers for Disease Control and Prevention (CDC) data on fatal drowning rates and membership rates from USA Swimming, the governing organization of competitive swimming in the United States. Tobit and Poisson regression models are estimated using panel data by state from 1999–2007 separately for males, females, African Americans and whites. The strong inverse relationship between competitive swimming rates and unintentional deaths through fatal drowning is most pronounced among African Americans males.

The Moon

NASA Image and Video Library

2017-12-08

This composite image of the moon using Clementine data from 1994 is the view we are most likely to see when the moon is full. Credit: NASA To learn about NASA's LRO project go to: www.nasa.gov/mission_pages/LRO/main/index.html NASA Goddard Space Flight Center contributes to NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s endeavors by providing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

Magneto-electronic coupling in modulated defect-structures of natural Fe{sub 1−x}S

DOE Office of Scientific and Technical Information (OSTI.GOV)

Charilaou, M., E-mail: charilaou@mat.ethz.ch; Löffler, J. F.; Kind, J.

2015-08-28

We provide compelling experimental evidence that the low-temperature transition in natural non-stoichiometric Fe{sub 7}S{sub 8}, a major magnetic remanence carrier in the Earth's crust and in extraterrestrial materials, is a phenomenon caused by magnetic coupling between epitaxially intergrown superstructures. The two superstructures differ in their defect distribution, and consequently in their magnetic anisotropy. At T < 30 K, the magnetic moments of the superstructures become strongly coupled, resulting in a 12-fold anisotropy symmetry, which is reflected in the anisotropic magneto-resistance.

Curriculum Management: "Driving the School Management Team Frantic"

ERIC Educational Resources Information Center

Lumadi, M. W.

2012-01-01

This study explores factors which have a negative impact, on the role of the School Management Team (SMT) that serves as the fulcrum of the curriculum management process. The SMT is compelled to execute its responsibilities in an efficient and effective manner thus keeping a delicate balance between the often-conflicting pressures from parents,…

The Achievement Consequences of the No Child Left Behind Act. Working Paper

ERIC Educational Resources Information Center

Dee, Thomas S.; Jacob, Brian A.

2009-01-01

The No Child Left Behind (NCLB) Act has compelled states to design school accountability systems based on annual student assessments. The effect of this Federal legislation on the distribution of student achievement is a highly controversial but centrally important question. This study presents evidence on whether NCLB has influenced student…

Learning To Value English: Cultural Capital in a Two-Way Bilingual Program.

ERIC Educational Resources Information Center

McCollum, Pam

1999-01-01

A 3-year ethnographic study of middle-school students in a two-way bilingual program found that Mexican-background students learned to value English over Spanish at school. The hidden curriculum, instructional practices, and assessment policy devalued the students' native linguistic cultural capital compelling them to use English in the classroom…

e-Learning Risks: Why Universities Should NOT Go It Alone

ERIC Educational Resources Information Center

Matthews, Tim; Pickar, Gloria; Schneid, Tom

2007-01-01

With $1M, faculty support, and their reputation at risk, Eastern Kentucky University (EKU) sought a distance learning partner to assess the MS in Loss Prevention & Safety opportunity, and then market the program to qualified students ready to learn. This compelling case study demonstrates how marketplace demand and competitive advantage can…

Is Literacy Enough? Pathways to Academic Success for Adolescents

ERIC Educational Resources Information Center

Snow, Catherine E.; Porche, Michelle V.; Tabors, Patton O.; Harris, Stephanie R.

2007-01-01

Four literacy experts lay out the evidence in this compelling book, based on the well-known Home-School Study of Language and Literacy Development that inspired the landmark resource "Beginning Literacy with Language." Following a group of children living in low-income families from preschool through high school, the authors charted the students'…

Parental Migration and Children's Academic Engagement: The Case of China

ERIC Educational Resources Information Center

Chen, Shuang; Adams, Jennifer; Qu, Zhiyong; Wang, Xiaohua; Chen, Li

2013-01-01

In the context of China's increasing rural-urban migration, few studies have investigated how parental migration affects children's experience in school. The high cost of schooling, taken together with the institutional barriers in destination cities, have compelled many rural parents in China to migrate without their children, leaving them in the…

Immortality of Prejudice in Striving Ubuntu: Case Studies of Community Managed Schools in Nepal

ERIC Educational Resources Information Center

Rajbhandari, Mani Man Singh; Rajbhandari, Smriti

2016-01-01

The immortality of prejudice after the school management transfer has not been judged. This makes communities to take responsibility for schools further by compelling the government to mandate amendments of Community Managed Schools (CMS) Directives. The purpose was to explore the CMS enduring Ubuntu against immorality of prejudice, through…

Asset-Based Assessment in Educational Psychology: Capturing Perceptions during a Paradigm Shift

ERIC Educational Resources Information Center

Lubbe, Carien; Eloff, Irma

2004-01-01

Several trends are compelling educational psychologists towards a philosophy of assessment that is asset-based and strength focused. This article shares the results from a study that explored perceptions about asset-based assessment in Educational Psychology in South Africa. Three focus groups were held and four main themes emerged from the…

An Effort to Close Achievement Gaps at Scale through Self-Affirmation

ERIC Educational Resources Information Center

Borman, Geoffrey D.; Grigg, Jeffrey

2013-01-01

This study addresses closing the academic performance gaps between African American and Latino students and their White counterparts, and between girls and boys in mathematics. Of the various models and theories of these social inequalities that have been advanced in literature, one particularly compelling line of research concerns the idea of…

Assessing the Positive Influence of Music Activities in Community Development Programs

ERIC Educational Resources Information Center

Dillon, Steve

2006-01-01

This article describes a framework for assessing the positive influence of music activities in community development programs. It examines hybrid music, health and rich media approaches to creative case study with the purpose of developing more compelling evidence based advocacy that examines the claims of a causal link. This preliminary study…

The Politics of the ICT4ED (Fatih) Project in Turkey

ERIC Educational Resources Information Center

Tolu, Hüseyin

2014-01-01

Information and communications technology (ICT) is crucial in any contemporary society, especially if its online presence is to be widely significant, but, in a national context, it is important to investigate whether there is a compelling ICT "politic" in the education sector in Turkey. This study specifically focuses on the ICT for…

Teaching Problem-Solving Competency in Business Studies at Secondary School Level

ERIC Educational Resources Information Center

Meintjes, Aloe; Henrico, Alfred; Kroon, Japie

2015-01-01

The high unemployment rate in South Africa compels potential entrepreneurs to start their own businesses in order to survive. Often this is with little or no formal training or education in entrepreneurship. Since problem recognition and problem-solving are amongst the most crucial competencies required for a successful entrepreneurial career,…

Compelling Evidence: An Influence on Middle School Students' Accounts That May Impact Decision-Making about Socioscientific Issues

ERIC Educational Resources Information Center

Emery, Katherine; Harlow, Danielle; Whitmer, Ali; Gaines, Steven

2017-01-01

This study investigates how middle school students make hypothetical purchasing, consuming, and voting decisions about environmental and science-related issues--a key component of environmental literacy. Fifty-three female students were given a packet containing multiple excerpts of information from conflicting positions from stakeholders and…

The Custody Evaluation Handbook: Research-Based Solutions and Applications.

ERIC Educational Resources Information Center

Bricklin, Barry

Three of the most challenging problems in the custody evaluation field follow from: (1) the difficulties involved in adapting data derived from group studies or traditional tests into a form for individual cases; (2) the absence of clear and compelling guidelines to aggregate the information collected in a comprehensive evaluation; and (3) the…

Using Second Life to Teach about Marketing in Second Life

ERIC Educational Resources Information Center

Halvorson, Wade; Ewing, Mike; Windisch, Lydia

2011-01-01

There are compelling reasons for educators to consider incorporating virtual worlds (VWs) in their marketing curriculum. That said, the ways in which VWs can be implemented into the teaching curriculum are many and varied. This article reports on two studies in which notionally similar graduate classes are taught about marketing in Second Life…

From the Fear of Death to the Fear of "Dissimilar Other": A Research in Elementary School Classrooms

ERIC Educational Resources Information Center

Leondari, A.; Magos, K.; Oikonomou, A.

2014-01-01

Social stereotyping and prejudice constitute pressing societal problems and have many causes. Terror Management Theory offers a compelling and heavily researched account of individuals' reactions towards "dissimilar others" when faced with thoughts of mortality. Building from previous research with adult samples, the present study aimed…

Women Pursuing Higher Education in Ultra-Orthodox Society

ERIC Educational Resources Information Center

Baum, Nehami; Yedidya, Tova; Schwartz, Chaya; Aran, Ofra

2014-01-01

The study reported in this article concerns the beginnings of higher education for women in the Haredi (ultra-Orthodox) enclave in Israel. Haredi Jews are a self-secluded fundamentalist group committed to particularly strict interpretation of Jewish religious law. In recent years, they have been compelled by poverty and other factors to allow…

Factors Influencing the Quality of EHR Performance: An Exploratory Qualitative Study

ERIC Educational Resources Information Center

Rhodes, Harry B.

2016-01-01

A significant amount of evidence existed in support of the positive effect on the quality of healthcare that resulted from transitioning to electronic health information systems, equally compelling evidence suggests that the development process for electronic health information systems falls short of achieving its potential. The objective of this…

Understanding Planned Change among Remote Nonfaculty Employees in Higher Education

ERIC Educational Resources Information Center

Lubin, Erin Heather

2017-01-01

Implementing planned change in online university divisions with remote nonfaculty employees is a unique challenge. The problem that compelled this study was the need to understand the challenges of implementing planned change for a group of geographically remote nonfaculty employees who served as field team members (FTM) in an online university's…

Place-Based Education and Teaching about Marin County Birds: Curriculum Development for Teachers

ERIC Educational Resources Information Center

Barnett, Sharon Anne

2009-01-01

Compelling evidence illustrates place-based education (PBE) as a catalyst for inspiring teachers to create dynamic curricula that energizes the student. PBE curriculum typically encompasses all traditional subjects and entails hands-on classroom and field studies utilizing the natural world and local community. The purpose of this literature…

A, B, CD, DVD: Marketing Higher Education to the Millennial Generation

ERIC Educational Resources Information Center

Furbeck, Lee F.; Harding, Marc L.; Wohlgemuth, Darin R.; Bousquet, David R.

2003-01-01

Based on compelling financial and strategic reasons, Iowa State University replaced its paper viewbook with a CD-ROM digital viewbook following the Fall 1998 recruiting cycle. The first interactive DVD viewbook debuted for the Fall 2003 recruiting cycle, following a qualitative research study designed to gauge the effectiveness of the medium.…

Media Studies Orientations for Israel Education: Lessons from "In Treatment," "Homeland," and "Z-Cars"

ERIC Educational Resources Information Center

Gottlieb, Owen

2013-01-01

Israeli film and television have risen to international prominence, presenting compelling and complicating perspectives. Simultaneously, Web 2.0 technologies have accelerated the spread and immediacy of digital media. Following the work of Holtz (2003) and Levisohn (2010) in developing orientations for teaching Bible and Rabbinic Literature, this…

The Historical Representation of Thanksgiving within Primary- and Intermediate-Level Children's Literature

ERIC Educational Resources Information Center

Bickford, John H., III; Rich, Cynthia W.

2015-01-01

State and national initiatives have compelled significant change in English language arts and social studies/history curricula. English language arts teachers are required to balance fiction (or literature) and nonfiction (or informational texts), which is a considerable change for a content area formerly occupied by fiction (National Governors…

The UARS (Upper Atmosphere Research Satellite): A program to study global ozone change

NASA Technical Reports Server (NTRS)

1989-01-01

NASA's Upper Atmosphere Research Satellite (UARS) program, its goals and objectives are described. Also included are its significance to upper atmosphere science, the experimental and theoretical investigations that comprise it, and the compelling issues of global change, driven by human activities, that led NASA to plan and implement it.

From Dissemination to Propagation: A New Paradigm for Education Developers

ERIC Educational Resources Information Center

Froyd, Jeffrey E.; Henderson, Charles; Cole, Renée S.; Friedrichsen, Debra; Khatri, Raina; Stanford, Courtney

2017-01-01

Scholarly studies and national reports document failure of current efforts to achieve broad, sustained adoption of research-based instructional practices, despite compelling bodies of evidence supporting efficacy of many of these practices. The authors of this paper argue that many change agents who are working to promote systemic adoption of…

Poverty and Brain Development in Children: Implications for Learning

ERIC Educational Resources Information Center

Dike, Victor E.

2017-01-01

Debates on the effect of poverty on brain development in children and its implications for learning have been raging for decades. Research suggests that poverty affects brain development in children and that the implications for learning are more compelling today given the attention the issue has attracted. For instance, studies in the fields of…

Parents' Decision on Child Labour and School Attendance: Evidence from Iranian Households

ERIC Educational Resources Information Center

Keshavarz Haddad, GholamReza

2017-01-01

In the framework of a household's collective decision processes, this study presents a structural empirical model to test the hypothesis that child labour is compelled by household's poverty and parent's bargaining power against one another. To this end, a measure for mother's intra-household bargaining power is developed. I use Iranian…

Political Influence and the Commander in Chief: Congress, the President, and War Powers

DTIC Science & Technology

2006-01-01

consultation with congressional leaders. Framed against the background of the 2006 midterm elections, this study suggests that scholars and other observers...potential v presidential consultation with congressional leaders. Framed against the background of the 2006 midterm elections, this study suggests that...wonder, for war powers politics offers a compelling arena for studying a variety of political phenomena, running the conceptual gamut from American

Let it go: Relationship autonomy predicts pro-relationship responses to partner transgressions.

PubMed

Hadden, Benjamin W; Baker, Zachary G; Knee, C Raymond

2017-11-24

The purpose of the present research is to better understand how relationship autonomy-having more self-determined reasons for being committed to a relationship-contributes to pro-relationship responses to transgressions in romantic relationships (e.g., forgiveness and accommodation). Study 1 employed a cross-sectional design (N = 350) and Study 2 used a weekly diary (N = 121) to test associations between relationship autonomy and pro-relationship responses to transgressions. Studies 3 and 4 utilized dyadic designs (Study 3: N = 200 couples, 400 individuals; Study 4: N = 275 couples, 550 individuals) to determine how both partners' relationship autonomy is associated with pro-relationship responses. Results revealed that relationship autonomy is robustly associated with pro-relationship responses to transgressions, both as general tendencies and as responses to idiosyncratic transgressions. Results of actor-partner interdependence model (APIM) analyses in Studies 3 and 4 provide evidence that one's partner's relationship autonomy is important for promoting pro-relationship responses as well. Study 4 also found that people perceive that partners respond better to transgressions if their partner is high in relationship autonomy. This research provides consistent and compelling evidence that the degree of self-determination underlying commitment is important for understanding how people respond to transgressions in their relationships, beyond their current levels of commitment. © 2017 Wiley Periodicals, Inc.

The Role of Tobacco-Derived Carcinogens in Pancreas Cancer

PubMed Central

Lochan, Rajiv; Reeves, Helen L.; Daly, Anne K.; Charnley, Richard M.

2011-01-01

The extremely poor outcome from pancreas cancer is well known. However, its aetiology less well appreciated, and the molecular mechanisms underlying this are poorly understood. Tobacco usage is one of the strongest risk factors for this disease, and this is a completely avoidable hazard. In addition, there are well described hereditary diseases which predispose, and familial pancreas cancer. We have sought here to summarise the role of tobacco-derived carcinogens and the mode of their tumorigenic action on the pancreas. There is compelling evidence from animal and human studies (laboratory including cell line studies and epidemiologic) that tobacco derived carcinogens cause pancreas cancer. However, the manner in which they do so is not entirely apparent. There is also compelling evidence that synergism with genetic and other life-style factors—like diet obesity—results in a multifactorial causation of the disease. Ascertaining the role of tobacco carcinogens in the development of this cancer and their interaction with other risk factors will enable novel therapeutic and preventative strategies to improve outcome from this appalling malignancy. PMID:22084727

Toward a Biosignature for Suicide

PubMed Central

Oquendo, Maria A.; Sullivan, Gregory M.; Sudol, Katherin; Baca-Garcia, Enrique; Stanley, Barbara H.; Sublette, M. Elizabeth; Mann, J. John

2015-01-01

Objective Suicide, a major cause of death worldwide, has distinct biological underpinnings. The authors review and synthesize the research literature on biomarkers of suicide, with the aim of using the findings of these studies to develop a coherent model for the biological diathesis for suicide. Method The authors examined studies covering a large range of neurobiological systems implicated in suicide. They provide succinct descriptions of each system to provide a context for interpreting the meaning of findings in suicide. Results Several lines of evidence implicate dysregulation in stress response systems, especially the hypothalamic-pituitary-adrenal axis, as a diathesis for suicide. Additional findings related to neuroinflammatory indices, glutamatergic function, and neuronal plasticity at the cellular and circuitry level may reflect downstream effects of such dysregulation. Whether serotonergic abnormalities observed in individuals who have died by suicide are independent of stress response abnormalities is an unresolved question. Conclusions The most compelling biomarkers for suicide are linked to altered stress responses and their downstream effects, and to abnormalities in the serotonergic system. Studying these systems in parallel and in the same populations may elucidate the role of each and their interplay, possibly leading to identification of new treatment targets and biological predictors. PMID:25263730

Using the Q-Connectivity Method to Study Frequency of Interaction with Multiple Peer Triads: Do Preschoolers' Peer Group Interactions at School Relate to Academic Skills?

ERIC Educational Resources Information Center

Hanish, Laura D.; Barcelo, Helene; Martin, Carol Lynn; Fabes, Richard A.; Holmwall, Jennifer; Palermo, Francisco

2007-01-01

How, when, and under what conditions do peer interactions contribute to variations in developmental trajectories along dimensions that are important to children's well-being? These compelling and fundamental questions have piqued the interest of developmental scientists and led to studies of the ways in which peers socialize and affect such…

Online Social Networking Goes to College: Two Case Studies of Higher Education Institutions That Implemented College-Created Social Networking Sites for Recruiting Undergraduate Students

ERIC Educational Resources Information Center

Ferguson, Christopher Paul

2010-01-01

With increased competition among higher education institutions for best- fit students, the profession of college admissions is compelled to implement innovative recruiting strategies (e.g. online social networking sites), that may impact college access and persistence in the United States. This qualitative study examined the reasons why two…

Dynamic Connectivity Patterns in Conscious and Unconscious Brain

PubMed Central

Ma, Yuncong; Hamilton, Christina

2017-01-01

Abstract Brain functional connectivity undergoes dynamic changes from the awake to unconscious states. However, how the dynamics of functional connectivity patterns are linked to consciousness at the behavioral level remains elusive. In this study, we acquired resting-state functional magnetic resonance imaging data during wakefulness and graded levels of consciousness in rats. Data were analyzed using a dynamic approach combining the sliding window method and k-means clustering. Our results demonstrate that whole-brain networks contained several quasi-stable patterns that dynamically recurred from the awake state into anesthetized states. Remarkably, two brain connectivity states with distinct spatial similarity to the structure of anatomical connectivity were strongly biased toward high and low consciousness levels, respectively. These results provide compelling neuroimaging evidence linking the dynamics of whole-brain functional connectivity patterns and states of consciousness at the behavioral level. PMID:27846731

Classification of Weed Species Using Artificial Neural Networks Based on Color Leaf Texture Feature

NASA Astrophysics Data System (ADS)

Li, Zhichen; An, Qiu; Ji, Changying

The potential impact of herbicide utilization compel people to use new method of weed control. Selective herbicide application is optimal method to reduce herbicide usage while maintain weed control. The key of selective herbicide is how to discriminate weed exactly. The HIS color co-occurrence method (CCM) texture analysis techniques was used to extract four texture parameters: Angular second moment (ASM), Entropy(E), Inertia quadrature (IQ), and Inverse difference moment or local homogeneity (IDM).The weed species selected for studying were Arthraxon hispidus, Digitaria sanguinalis, Petunia, Cyperus, Alternanthera Philoxeroides and Corchoropsis psilocarpa. The software of neuroshell2 was used for designing the structure of the neural network, training and test the data. It was found that the 8-40-1 artificial neural network provided the best classification performance and was capable of classification accuracies of 78%.

The essential value of long-term experimental data for hydrology and water management

NASA Astrophysics Data System (ADS)

Tetzlaff, D.; Carey, S. K.; McNamara, J. P.; Laudon, H.; Soulsby, C.

2017-12-01

Observations and data from long-term experimental watersheds are the foundation of hydrology as a geoscience. They allow us to benchmark process understanding, observe trends and natural cycles, and are pre-requisites for testing predictive models. Long-term experimental watersheds also are places where new measurement technologies are developed. These studies offer a crucial evidence base for understanding and managing the provision of clean water supplies; predicting and mitigating the effects of floods, and protecting ecosystem services provided by rivers and wetlands. They also show how to manage land and water in an integrated, sustainable way that reduces environmental and economic costs. We present a number of compelling examples illustrating how hydrologic process understanding has been generated through comparing hypotheses to data, and how this understanding has been essential for managing water supplies, floods, and ecosystem services today.

Using climate models to estimate the quality of global observational data sets.

PubMed

Massonnet, François; Bellprat, Omar; Guemas, Virginie; Doblas-Reyes, Francisco J

2016-10-28

Observational estimates of the climate system are essential to monitoring and understanding ongoing climate change and to assessing the quality of climate models used to produce near- and long-term climate information. This study poses the dual and unconventional question: Can climate models be used to assess the quality of observational references? We show that this question not only rests on solid theoretical grounds but also offers insightful applications in practice. By comparing four observational products of sea surface temperature with a large multimodel climate forecast ensemble, we find compelling evidence that models systematically score better against the most recent, advanced, but also most independent product. These results call for generalized procedures of model-observation comparison and provide guidance for a more objective observational data set selection. Copyright © 2016, American Association for the Advancement of Science.

Assembly of micro/nanomaterials into complex, three-dimensional architectures by compressive buckling

NASA Astrophysics Data System (ADS)

Xu, Sheng; Yan, Zheng; Jang, Kyung-In; Huang, Wen; Fu, Haoran; Kim, Jeonghyun; Wei, Zijun; Flavin, Matthew; McCracken, Joselle; Wang, Renhan; Badea, Adina; Liu, Yuhao; Xiao, Dongqing; Zhou, Guoyan; Lee, Jungwoo; Chung, Ha Uk; Cheng, Huanyu; Ren, Wen; Banks, Anthony; Li, Xiuling; Paik, Ungyu; Nuzzo, Ralph G.; Huang, Yonggang; Zhang, Yihui; Rogers, John A.

2015-01-01

Complex three-dimensional (3D) structures in biology (e.g., cytoskeletal webs, neural circuits, and vasculature networks) form naturally to provide essential functions in even the most basic forms of life. Compelling opportunities exist for analogous 3D architectures in human-made devices, but design options are constrained by existing capabilities in materials growth and assembly. We report routes to previously inaccessible classes of 3D constructs in advanced materials, including device-grade silicon. The schemes involve geometric transformation of 2D micro/nanostructures into extended 3D layouts by compressive buckling. Demonstrations include experimental and theoretical studies of more than 40 representative geometries, from single and multiple helices, toroids, and conical spirals to structures that resemble spherical baskets, cuboid cages, starbursts, flowers, scaffolds, fences, and frameworks, each with single- and/or multiple-level configurations.

First saccadic eye movement reveals persistent attentional guidance by implicit learning

PubMed Central

Jiang, Yuhong V.; Won, Bo-Yeong; Swallow, Khena M.

2014-01-01

Implicit learning about where a visual search target is likely to appear often speeds up search. However, whether implicit learning guides spatial attention or affects post-search decisional processes remains controversial. Using eye tracking, this study provides compelling evidence that implicit learning guides attention. In a training phase, participants often found the target in a high-frequency, “rich” quadrant of the display. When subsequently tested in a phase during which the target was randomly located, participants were twice as likely to direct the first saccadic eye movement to the previously rich quadrant than to any of the sparse quadrants. The attentional bias persisted for nearly 200 trials after training and was unabated by explicit instructions to distribute attention evenly. We propose that implicit learning guides spatial attention but in a qualitatively different manner than goal-driven attention. PMID:24512610

Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target

PubMed Central

Chen, Mo; Peters, Alec; Huang, Tao; Nan, Xiaolin

2016-01-01

The K-, N-, and HRas small GTPases are key regulators of cell physiology and are frequently mutated in human cancers. Despite intensive research, previous efforts to target hyperactive Ras based on known mechanisms of Ras signaling have been met with little success. Several studies have provided compelling evidence for the existence and biological relevance of Ras dimers, establishing a new mechanism for regulating Ras activity in cells additionally to GTP-loading and membrane localization. Existing data also start to reveal how Ras proteins dimerize on the membrane. We propose a dimer model to describe Ras-mediated effector activation, which contrasts existing models of Ras signaling as a monomer or as a 5-8 membered multimer. We also discuss potential implications of this model in both basic and translational Ras biology. PMID:26423697

Horizontal Launch: A Versatile Concept for Assured Space Access

NASA Technical Reports Server (NTRS)

Bartolotta, Paul; Wilhite, Alan W.; Schaffer, Mark; Voland, Randall T.; Huebner, Larry

2011-01-01

The vision of horizontal launch is the capability to provide a mobile launch pad that can use existing aircraft runways, cruise above weather, loiter for mission instructions, and achieve precise placement for orbital intercept, rendezvous, or reconnaissance. Another compelling benefit of horizontal launch is that today s ground-based vertical launch pads are a single earthquake, hurricane, or terrorist attack away from disruption of critical U.S. launch capabilities. The study did not attempt to design a new system concept for horizontal launch, but rather focused on the refinement of many previously-studied horizontal launch concepts. Because of the large number of past horizontal launch studies, a process was developed to narrow the number of concepts through prescreening, screening, and evaluation of point designs. The refinement process was not intended to select the "best" concept, but rather to establish the feasibility of horizontal launch from a balanced assessment of figures of merit and to identify potential concepts that warrant further exploration.

Guideline implementation strategies for specialist mental healthcare.

PubMed

Girlanda, Francesca; Fiedler, Ines; Ay, Esra; Barbui, Corrado; Koesters, Markus

2013-07-01

Clinical practice guidelines in mental healthcare are viewed as an essential asset if appropriately developed and implemented. The purpose of this article was to review the existing literature on how guidelines should be implemented to optimize their impact on provider performance and patient outcomes in specialist mental healthcare settings. Findings from recent studies suggest a trend toward an improvement in process and patient outcomes following guideline implementation. However, studies are heterogeneous in terms of design, implementation strategies and outcome measures, making it very difficult to draw firm conclusions about which implementation strategy is effective in different healthcare contexts. Current knowledge about how guidelines should be implemented is still sparse and inconclusive in mental healthcare. Future studies should attempt to employ more rigorous designs, including random allocation of patients or clusters of patients, to shed further light on this compelling issue. Research on guideline implementation strategies should additionally take into account potential barriers to knowledge translation, which can heavily influence the implementability of treatment recommendations.

Challenges and solutions for studying collective animal behaviour in the wild.

PubMed

Hughey, Lacey F; Hein, Andrew M; Strandburg-Peshkin, Ariana; Jensen, Frants H

2018-05-19

Mobile animal groups provide some of the most compelling examples of self-organization in the natural world. While field observations of songbird flocks wheeling in the sky or anchovy schools fleeing from predators have inspired considerable interest in the mechanics of collective motion, the challenge of simultaneously monitoring multiple animals in the field has historically limited our capacity to study collective behaviour of wild animal groups with precision. However, recent technological advancements now present exciting opportunities to overcome many of these limitations. Here we review existing methods used to collect data on the movements and interactions of multiple animals in a natural setting. We then survey emerging technologies that are poised to revolutionize the study of collective animal behaviour by extending the spatial and temporal scales of inquiry, increasing data volume and quality, and expediting the post-processing of raw data.This article is part of the theme issue 'Collective movement ecology'. © 2018 The Author(s).

A Spoonful of (Added) Sugar Helps the Constitution Go Down: Curing the Compelled Speech Commercial Speech Doctrine with FDA’s Added Sugars Rule.

PubMed

Smith, Colleen

On May 27, 2016, the Food and Drug Administration (FDA) announced that it was adopting a new rule that requires food manufacturers to list—on the already mandated Nutrition Facts label—how many grams of sugar have been added to a food product. Many opponents have criticized this “added sugars” rule on First Amendment grounds, arguing that the rule violates the commercial speech rights of food manufacturers. Whether the rule would survive constitutional scrutiny or not is an open question because the compelled commercial speech doctrine is anything but clear. Courts are split over whether Zauderer’s rational basis test, Central Hudson’s intermediate scrutiny, or some combination of the two should apply to a mandated disclosure like FDA’s added sugars rule. This Paper explains that the added sugars rule is unique in the history of mandated nutrition labeling in that the rule is motivated largely by public health concerns and backed by reports that assert that consumers should limit their intake of added sugars. In contrast, correcting and preventing consumer deception has been a major driving force behind the remainder of FDA’s mandated nutrition labeling. Because of this distinct rationale, the added sugars rule does not fit neatly into any currently existing compelled commercial speech test. This Paper uses the added sugars rule to highlight the deficiencies in the existing tests. Finally, this Paper proposes a new compelled commercial speech test that would adequately balance the interest of all of the effected parties: the government, the public, and food manufacturers.

Shining lights: studies that have most influenced the understanding of health promotion's financial impact.

PubMed

Golaszewski, T

2001-01-01

To examine the literature from the past 20 years and identify those studies that support the economic merit of health promotion. A panel of experts was used to identify the top studies supporting the purpose of this article. Studies were chosen based on the following criteria: the study (1) examined the relationship between health risks and financial outcomes, or health promotion programs and financial outcomes; (2) provided strong and compelling financial data supporting the worth of health promotion; (3) had a high-quality methodology; (4) answered an important question or replicated important findings with superior methodology; and (5) represented U.S.-based initiatives published since 1980. After initially nominating a group of studies for consideration, panelists rated each on a scale from 1 to 3 representing their opinion of importance. Studies rating the highest were included for this discussion. Studies were analyzed by population characteristics, design, statistical tests, limitations, and results. This information was summarized for each identified article. A relationship between modifiable health risk factors and health care costs is supported by research. Health promotion interventions appear to provide positive financial returns, most notably for health care costs and absenteeism reduction. Private sector initiatives seem to be driving economic-based research. Overall, health promotion shows promising results for providing financial advantages for its sponsors; however, if this discipline is to show its true worth, considerable funding is needed from government or philanthropic sources to cover the substantial costs of quality research.

Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

PubMed

Church, Stephanie J; Begley, Paul; Kureishy, Nina; McHarg, Selina; Bishop, Paul N; Bechtold, David A; Unwin, Richard D; Cooper, Garth J S

2015-05-08

Ob/ob mice provide an animal model for non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH) in patients with obesity and type-2 diabetes. Low liver copper has been linked to hepatic lipid build-up (steatosis) in animals with systemic copper deficiency caused by low-copper diets. However, hepatic copper status in patients with NAFLD or NASH is uncertain, and a validated animal model useful for the study of hepatic copper regulation in common forms of metabolic liver disease is lacking. Here, we report parallel measurements of essential metal levels in whole-liver tissue and defatted-dried liver tissue from ob/ob and non-obese control mice. Measurements in whole-liver tissue from ob/ob mice at an age when they have developed NAFLD/NASH, provide compelling evidence for factitious lowering of copper and all other essential metals by steatosis, and so cannot be used to study hepatic metal regulation in this model. By marked contrast, metal measurements in defatted-dried liver samples reveal that most essential metals were actually normal and indicate specific lowering of copper in ob/ob mice, consistent with hepatic copper deficiency. Thus ob/ob mice can provide a model useful for the study of copper regulation in NAFLD and NASH, provided levels are measured in defatted-dried liver tissue. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Predictive Value of Performance Criteria for First-Time Sophomore Resident Assistants

ERIC Educational Resources Information Center

Severance, Dana A.

2015-01-01

Housing professionals are increasingly compelled to consider hiring resident assistants (RAs) from a pool of applicants that includes students with less college experience than has traditionally been expected. The purpose of the study is to determine if the success of first-time sophomore RAs differs from that of first-time upper-class RAs…

In Favour of Ethics Education, against Religious Education

ERIC Educational Resources Information Center

Tillson, John

2011-01-01

The questions that I address are: "What ought to become of Religious Education (RE)?" and "To what extent do non-religious beliefs belong in RE?" I will argue that there are compelling reasons for studying religious and non-religious views alongside each other, but that there are serious objections to doing this in the context of any subject…

Language Views on Social Networking Sites for Language Learning: The Case of Busuu

ERIC Educational Resources Information Center

Álvarez Valencia, José Aldemar

2016-01-01

Social networking has compelled the area of computer-assisted language learning (CALL) to expand its research palette and account for new virtual ecologies that afford language learning and socialization. This study focuses on Busuu, a social networking site for language learning (SNSLL), and analyzes the views of language that are enacted through…

43 CFR 404.28 - Is it possible to expedite the completion of an appraisal investigation or feasibility study?

Code of Federal Regulations, 2010 CFR

2010-10-01

... served by a proposed rural water supply project has urgent and compelling water needs, Reclamation will... Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.28 Is it possible to expedite the completion of an appraisal investigation...

From Face-to-Face to Paired Oral Proficiency Interviews: The Nut Is yet to Be Cracked

ERIC Educational Resources Information Center

Birjandi, Parviz; Bagherkazemi, Marzieh

2011-01-01

The pressing need for English oral communication skills in multifarious contexts today is compelling impetus behind the large number of studies done on oral proficiency interviewing. Moreover, given the recently articulated concerns with the fairness and social dimension of such interviews, parallel concerns have been raised as to how most fairly…

The Impact of No Child Left Behind on Student Achievement. NBER Working Paper No. 15531

ERIC Educational Resources Information Center

Dee, Thomas; Jacob, Brian

2009-01-01

The No Child Left Behind (NCLB) Act compelled states to design school-accountability systems based on annual student assessments. The effect of this Federal legislation on the distribution of student achievement is a highly controversial but centrally important question. This study presents evidence on whether NCLB has influenced student…

The Longitudinal Impact of Distal, Non-Familial Relationships on Parental Monitoring: Implications for Delinquent Behavior

ERIC Educational Resources Information Center

Jaggers, Jeremiah W.; Bolland, Anneliese C.; Tomek, Sara; Bolland, Kathleen A.; Hooper, Lisa M.; Church, Wesley T., II; Bolland, John M.

2018-01-01

An extensive body of work shows that parental monitoring reduces the likelihood of risky behaviors among youth, yet little attention has been given to the factors compelling parents to engage in monitoring behaviors. The current study examines the association between non-familial, adolescent relationships (i.e., school connectedness, community…

Process Writing and the Internet: Blogs and Ning Networks in the Classroom

ERIC Educational Resources Information Center

Boas, Isabela Villas

2011-01-01

In contrast to the product approach to writing, which is based on studying and replicating textual models, the process approach involves multiple and repeated steps that compel the writer to closely consider the topic, language, purpose for writing, and social reality of an audience. In addition to discussing the benefits of the process approach…

VIVA! Community Arts and Popular Education in the Americas. SUNY Series, Praxis: Theory in Action [with DVD

ERIC Educational Resources Information Center

Barndt, Deborah, Ed.

2011-01-01

This compelling collection of inspiring case studies from community arts projects in five countries will inform and inspire students, artists, and activists. "VIVA!" is the product of a five-year transnational research project that integrates place, politics, passion, and praxis. Framed by postcolonial theories of decolonization, the…

Women in Line Administration: A Longitudinal Study in One State, 1972-2002

ERIC Educational Resources Information Center

Mertz, Norma T.

2003-01-01

Responding to compelling evidence of gender inequity and a systematic campaign of political pressure to redress these inequities, Congress passed Title IX of the Education Amendments of 1972 (20 U.S.C. 1681) prohibiting sex discrimination in all aspects of education in institutions receiving federal financial assistance. At the time Title IX was…

Comparison of Sustained and Selective Attention in Children Who Have Mental Retardation with and without Attention Deficit Hyperactivity Disorder.

ERIC Educational Resources Information Center

Pearson, Deborah A.; And Others

1996-01-01

This study compared children with attention deficit hyperactivity disorder (ADHD) and mental retardation with children with only mental retardation on tasks involving sustained and selective attention. No compelling evidence emerged for sustained attention deficits in the ADHD children, though evidence suggesting selective attention deficits was…

Impact of the Teacher Study Group Professional Development Program on Student Vocabulary and Observed Teaching Practice: A Replication in First Grade Classrooms

ERIC Educational Resources Information Center

Gersten, Russell; Dimino, Joseph; Jayanthi, Madhavi; Newman-Gonchar, Rebecca; Taylor, Mary Jo

2013-01-01

The ESEA Blueprint for Reform states that teachers need "effective, ongoing, job-embedded, professional development that is targeted to student and school needs… [and] aligned with evidence of improvements in student learning." Unfortunately, the professional development approaches advocated, though sensible and compelling in theory,…

Knowledge Utilization Strategies in the Design and Implementation of New Schools--Symbolic Functions.

ERIC Educational Resources Information Center

Sieber, Sam D.

An examination of case studies suggests that rational processes were not entirely at work in the planning and conception of new, innovative schools. The rational model that serves as the foundation of our information systems assumes that a compelling professional need triggers a search for solutions; and, therefore, school personnel are eager to…

The Stability of Kindergarten Teachers' Effectiveness: A Generalizability Study Comparing the Framework for Teaching and the Classroom Assessment Scoring System

ERIC Educational Resources Information Center

Mantzicopoulos, Panayota; French, Brian F.; Patrick, Helen; Watson, J. Samuel; Ahn, Inok

2018-01-01

To meet recent accountability mandates, school districts are implementing assessment frameworks to document teachers' effectiveness. Observational assessments play a key role in this process, albeit without compelling evidence of their psychometric rigor. Using a sample of kindergarten teachers, we employed Generalizability theory to investigate…

Young Women of Alaska Speak Out about Dropping Out.

ERIC Educational Resources Information Center

Bruce, Lauren

This report is the result of taped interviews with 115 Alaskan teenage women who have dropped out of "regular" public school. Two results of the study stand out: first, the majority of the students wanted a diploma, but nonetheless felt compelled to drop out; second (the reason most girls gave for dropping out): no one cared. However,…

Creating the Out-of-State University: Do Public Universities Increase Nonresident Freshman Enrollment in Response to Declining State Appropriations?

ERIC Educational Resources Information Center

Jaquette, Ozan; Curs, Bradley R.

2015-01-01

This study investigates whether public universities respond to declines in state appropriations by increasing nonresident freshman enrollment. State higher education appropriations declined substantially during the 2000s, compelling public universities to become more dependent on net-tuition revenue. State policy controls often limit the growth of…

Oxidative Damage in Diabetics: Insights from a Graduate Study in La Reunion University

ERIC Educational Resources Information Center

Girard, Dorothée; Rondeau, Philippe; Catan, Aurélie; Planesse, Cynthia; Giraud, Pierre; Bourdon, Emmanuel

2014-01-01

Due to the growing incidence of diabetes in developed nations, there is a compelling case to be made for teaching graduate students more deeply about mechanisms underlying this disease. Diabetes is associated with enhanced oxidative stress and protein glycation via the covalent binding of glucose molecules. Albumin represents the major plasmatic…

Teaching about Nature of Science through Short Lab Activities in Hong Kong Classroom

ERIC Educational Resources Information Center

Lau, Kwok-chi

2017-01-01

The study evaluated the effectiveness of using short, school lab investigations to teach about the nature of science (NOS). A manipulated lab inquiry approach was used, which modified the investigations in ways that students were compelled to experience certain NOS aspects. An investigation about apple browning was used to teach about the…

A Review of New Brunswick's Dedicated Notebook Research Project: One-to-One Computing--A Compelling Classroom-Change Intervention

ERIC Educational Resources Information Center

Milton, Penny

2008-01-01

The Canadian Education Association (CEA) was commissioned by Hewlett-Packard Canada to create a case study describing the development, implementation and outcomes of New Brunswick's Dedicated Notebook Research Project. The New Brunswick Department of Education designed its research project to assess impacts on teaching and learning of dedicated…

What Do Teenagers Want? What Do Teenagers Need?

ERIC Educational Resources Information Center

Strom, Kimberly; And Others

1995-01-01

Reports on the qualitative findings extracted from a study of over 3,700 teenagers from urban, suburban, and small city settings, describing the array of difficulties teenagers face today. The themes that emerged from the students' comments offer a compelling portrait of life as a teenager in the 1990s and help shape an agenda for understanding…

Psychotherapy supervision developments and innovations for the new millennium: contributions from the cutting edge.

PubMed

Watkins, C Edward

2014-01-01

What are some of the most recent, cutting-edge developments and innovations in psychotherapy supervision? And what is their particular significance for supervision now and into its future? In this special supervision issue of the American Journal of Psychotherapy, those questions are considered, and some compelling answers are provided. In what follows, I introduce this special journal issue: (a) define supervision and indicate its purposes; (b) summarize the contents of each innovative paper; and (c) accentuate the significance of each presented development/innovation. The papers contained in this issue boldly speak to supervision's future and provide exciting--and highly profitable--directions to pursue in forever making psychotherapy supervision a far more anchored, accountable, and educational experience.

Description of a new species of crested newt, previously subsumed in Triturus ivanbureschi (Amphibia: Caudata: Salamandridae).

PubMed

Wielstra, B; Arntzen, J W

2016-05-05

Multilocus molecular data play a pivotal role in diagnosing cryptic species (i.e. genetically distinct but morphologically similar species). A multilocus phylogeographic survey has provided compelling evidence that Triturus ivanbureschi sensu lato comprises two distinct gene pools with restricted gene flow. We conclude that this taxon had better be treated as two distinct (albeit morphologically cryptic) species. The name T. ivanbureschi should be restricted to the western species, which is distributed in western Asiatic Turkey plus the south-eastern Balkan Peninsula. No name is as yet available for the eastern species, which is distributed in northern Asiatic Turkey. We propose the name T. anatolicus sp. nov. for the eastern species and provide a formal species description.

Team reasoning: Solving the puzzle of coordination.

PubMed

Colman, Andrew M; Gold, Natalie

2017-11-03

In many everyday activities, individuals have a common interest in coordinating their actions. Orthodox game theory cannot explain such intuitively obvious forms of coordination as the selection of an outcome that is best for all in a common-interest game. Theories of team reasoning provide a convincing solution by proposing that people are sometimes motivated to maximize the collective payoff of a group and that they adopt a distinctive mode of reasoning from preferences to decisions. This also offers a compelling explanation of cooperation in social dilemmas. A review of team reasoning and related theories suggests how team reasoning could be incorporated into psychological theories of group identification and social value orientation theory to provide a deeper understanding of these phenomena.

Are extreme hydro-meteorological events a prerequisite for extreme water quality impacts? Exploring climate impacts on inland and coastal waters

NASA Astrophysics Data System (ADS)

Michalak, A. M.; Balaji, V.; Del Giudice, D.; Sinha, E.; Zhou, Y.; Ho, J. C.

2017-12-01

Questions surrounding water sustainability, climate change, and extreme events are often framed around water quantity - whether too much or too little. The massive impacts of extreme water quality impairments are equally compelling, however. Recent years have provided a host of compelling examples, with unprecedented harmful algal blooms developing along the West coast, in Utah Lake, in Lake Erie, and off the Florida coast, and huge hypoxic dead zones continuing to form in regions such as Lake Erie, the Chesapeake Bay, and the Gulf of Mexico. Linkages between climate change, extreme events, and water quality impacts are not well understood, however. Several factors explain this lack of understanding, including the relative complexity of underlying processes, the spatial and temporal scale mismatch between hydrologists and climatologists, and observational uncertainty leading to ambiguities in the historical record. Here, we draw on a number of recent studies that aim to quantitatively link meteorological variability and water quality impacts to test the hypothesis that extreme water quality impairments are the result of extreme hydro-meteorological events. We find that extreme hydro-meteorological events are neither always a necessary nor a sufficient condition for the occurrence of extreme water quality impacts. Rather, extreme water quality impairments often occur in situations where multiple contributing factors compound, which complicates both attribution of historical events and the ability to predict the future incidence of such events. Given the critical societal importance of water quality projections, a concerted program of uncertainty reduction encompassing observational and modeling components will be needed to examine situations where extreme weather plays an important, but not solitary, role in the chain of cause and effect.

The storytelling brain. Commentary on "On social attribution: implications of recent cognitive neuroscience research for race, law, and politics".

PubMed

Nigam, Sanjay K

2012-09-01

The well-established techniques of the professional storyteller not only have the potential to model complex "truth" but also to dig deeply into that complexity, thereby perhaps getting closer to that truth. This applies not only to fiction, but also to medicine and even science. Compelling storytelling ability may have conferred an evolutionary survival advantage and, if so, is likely represented in the neural circuitry of the human brain. Functional imaging will likely point to a neuroanatomical basis for compelling storytelling ability; this will presumably reflect underlying cellular and molecular mechanisms.

Carbon Nanotubes: Present and Future Commercial Applications

NASA Astrophysics Data System (ADS)

De Volder, Michael F. L.; Tawfick, Sameh H.; Baughman, Ray H.; Hart, A. John

2013-02-01

Worldwide commercial interest in carbon nanotubes (CNTs) is reflected in a production capacity that presently exceeds several thousand tons per year. Currently, bulk CNT powders are incorporated in diverse commercial products ranging from rechargeable batteries, automotive parts, and sporting goods to boat hulls and water filters. Advances in CNT synthesis, purification, and chemical modification are enabling integration of CNTs in thin-film electronics and large-area coatings. Although not yet providing compelling mechanical strength or electrical or thermal conductivities for many applications, CNT yarns and sheets already have promising performance for applications including supercapacitors, actuators, and lightweight electromagnetic shields.

Water Ice on Mercury

NASA Image and Video Library

2015-04-16

This orthographic projection view from NASA MESSENGER spacecraft provides a look at Mercury north polar region. The yellow regions in many of the craters mark locations that show evidence for water ice, as detected by Earth-based radar observations from Arecibo Observatory in Puerto Rico. MESSENGER has collected compelling new evidence that the deposits are indeed water ice, including imaging within the permanently shaded interiors of some of the craters, such as Prokofiev and Fuller. Instrument: Mercury Dual Imaging System (MDIS) Arecibo Radar Image: In yellow (Harmon et al., 2011, Icarus 211, 37-50) http://photojournal.jpl.nasa.gov/catalog/PIA19411

Introduction: Applying Clinical Psychological Science to Practice.

PubMed

Cha, Christine B; DiVasto, Katherine A

2017-05-01

Mental illness is a prevalent and extraordinarily complex phenomenon. Psychologists have developed distinct approaches toward understanding and treating mental illness, rooted in divergent epistemology. This introduction to the Special Issue on Clinical Psychological Science and Practice provides a brief overview of the scientist-practitioner gap, and explores one step (of many) toward bridging this divide. Seven compelling case illustrations featured in this Special Issue apply empirical findings to case formulation, treatment selection, and assessment across complex and varied clinical presentations. This issue thereby demonstrates the feasibility of integrating research and clinical expertise in mental healthcare. © 2017 Wiley Periodicals, Inc.

Twenty years of terahertz imaging [Invited].

PubMed

Mittleman, Daniel M

2018-04-16

The birth of terahertz imaging approximately coincides with the birth of the journal Optics Express. The 20 th anniversary of the journal is therefore an opportune moment to consider the state of progress in the field of terahertz imaging. This article discusses some of the compelling reasons that one may wish to form images in the THz range, in order to provide a perspective of how far the field has come since the early demonstrations of the mid-1990's. It then focuses on a few of the more prominent frontiers of current research, highlighting their impacts on both fundamental science and applications.

Overview of Common Sleep Disorders and Intersection with Dermatologic Conditions.

PubMed

Walia, Harneet K; Mehra, Reena

2016-04-30

Sleep disorders are very common, often under-recognized and therefore undertreated, are associated with a myriad of medical conditions and could lead to significant impairment of quality of life. This review provides an up-to-date synopsis of common sleep disorders encompassing insufficient sleep syndrome, insomnia, circadian rhythm disorders and obstructive sleep apnea with a brief overview of epidemiology, screening, diagnostic testing and treatment. We also emphasize the emerging area of the intersection of sleep disorders and dermatologic conditions and present compelling data regarding underlying mechanisms including sleep dysfunction in relation to disorders of skin inflammation, aging and skin cancer.

The neurobiology, diagnosis, and treatment of narcolepsy.

PubMed

Scammell, Thomas E

2003-02-01

Narcolepsy is a common cause of chronic sleepiness distinguished by intrusions into wakefulness of physiological aspects of rapid eye movement sleep such as cataplexy and hallucinations. Recent advances provide compelling evidence that narcolepsy may be a neurodegenerative or autoimmune disorder resulting in a loss of hypothalamic neurons containing the neuropeptide orexin (also known as hypocretin). Because orexin promotes wakefulness and inhibits rapid eye movement sleep, its absence may permit inappropriate transitions between wakefulness and sleep. These discoveries have considerably improved our understanding of the neurobiology of sleep and should foster the development of rational treatments for a variety of sleep disorders.

Carbon nanotubes: present and future commercial applications.

PubMed

De Volder, Michael F L; Tawfick, Sameh H; Baughman, Ray H; Hart, A John

2013-02-01

Worldwide commercial interest in carbon nanotubes (CNTs) is reflected in a production capacity that presently exceeds several thousand tons per year. Currently, bulk CNT powders are incorporated in diverse commercial products ranging from rechargeable batteries, automotive parts, and sporting goods to boat hulls and water filters. Advances in CNT synthesis, purification, and chemical modification are enabling integration of CNTs in thin-film electronics and large-area coatings. Although not yet providing compelling mechanical strength or electrical or thermal conductivities for many applications, CNT yarns and sheets already have promising performance for applications including supercapacitors, actuators, and lightweight electromagnetic shields.

Spark Ignition of Combustible Vapor in a Plastic Bottle as a Demonstration of Rocket Propulsion

NASA Astrophysics Data System (ADS)

Mattox, J. R.

2017-01-01

I report an innovation that provides a compelling demonstration of rocket propulsion, appropriate for students of physics and other physical sciences. An electrical spark is initiated from a distance to cause the deflagration of a combustible vapor mixed with air in a lightweight plastic bottle that is consequently propelled as a rocket by the release of combustion products, i.e., a "whoosh rocket." My recommendation is that the standard fuel for pedagogical whoosh demonstrations be isopropanol, and the recommended vessel is the 3.8-L high-density polyethylene (HDPE) bottle.

The Landsat program: Its origins, evolution, and impacts

USGS Publications Warehouse

Lauer, D.T.; Morain, S.A.; Salomonson, V.V.

1997-01-01

Landsat 1 began an era of space-based resource data collection that changed the way science, industry, governments, and the general public view the Earth. For the last 25 years, the Landsat program - despite being hampered by institutional problems and budget uncertainties - has successfully provided a continuous supply of synoptic, repetitive, multi-spectral data of the Earth's land areas. These data have profoundly affected programs for mapping resources, monitoring environmental changes, and assessing global habitability. The societal applications this program generated are so compelling that international systems have proliferated to carry on the tasks initiated with Landsat data.

Hard to Believe : Produced by Ken Stone and Irene Silber, 2015, Swoop Films and Stone Soup Productions (New York, 56 minutes, unrated).

PubMed

Northam, Holly Louise

2016-06-01

This article presents a review of Hard to Believe, a compelling documentary reporting the forced organ procurement and death of Chinese prisoners of conscience. The documentary is targeted to ignite political and public pressure to stop these practices that are thought to be motivated by financial and political gain. Narrated by journalist and author Ethan Gutmann, the documentary pricks at the collective conscience, as credible witnesses provide evidence that point to an abrogation of every ethical principle ascribed to legitimate organ procurement.

Of poops and parasites: unethical FDA overregulation.

PubMed

Young, Kenneth A

2014-01-01

Therapies born out of the Hygiene Hypothesis--such as helminthic therapy and fecal bacteriotherapy--provide a compelling example of the FDA's institutional blindness. Unlike the traditional pharmaceutical model of treatment, therapies based in the Hygiene Hypothesis purport to resolve or alleviate conditions by reintroducing organisms once thought to be wholly negative. While questions of negative effects and safety remain in the former, they are largely absent in the latter. Nonetheless, the FDA has chosen to regulate the use of both helminthic therapy and fecal bacteriotherapy. Such restriction of doctor-patient autonomy in the name of efficacy is costly and unethical.

The Ames Virtual Environment Workstation: Implementation issues and requirements

NASA Technical Reports Server (NTRS)

Fisher, Scott S.; Jacoby, R.; Bryson, S.; Stone, P.; Mcdowall, I.; Bolas, M.; Dasaro, D.; Wenzel, Elizabeth M.; Coler, C.; Kerr, D.

1991-01-01

This presentation describes recent developments in the implementation of a virtual environment workstation in the Aerospace Human Factors Research Division of NASA's Ames Research Center. Introductory discussions are presented on the primary research objectives and applications of the system and on the system's current hardware and software configuration. Principle attention is then focused on unique issues and problems encountered in the workstation's development with emphasis on its ability to meet original design specifications for computational graphics performance and for associated human factors requirements necessary to provide compelling sense of presence and efficient interaction in the virtual environment.

Relaxation of herbivore-mediated selection drives the evolution of genetic covariances between plant competitive and defense traits.

PubMed

Uesugi, Akane; Connallon, Tim; Kessler, André; Monro, Keyne

2017-06-01

Insect herbivores are important mediators of selection on traits that impact plant defense against herbivory and competitive ability. Although recent experiments demonstrate a central role for herbivory in driving rapid evolution of defense and competition-mediating traits, whether and how herbivory shapes heritable variation in these traits remains poorly understood. Here, we evaluate the structure and evolutionary stability of the G matrix for plant metabolites that are involved in defense and allelopathy in the tall goldenrod, Solidago altissima. We show that G has evolutionarily diverged between experimentally replicated populations that evolved in the presence versus the absence of ambient herbivory, providing direct evidence for the evolution of G by natural selection. Specifically, evolution in an herbivore-free habitat altered the orientation of G, revealing a negative genetic covariation between defense- and competition-related metabolites that is typically masked in herbivore-exposed populations. Our results may be explained by predictions of classical quantitative genetic theory, as well as the theory of acquisition-allocation trade-offs. The study provides compelling evidence that herbivory drives the evolution of plant genetic architecture. © 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution.

A robust demonstration of the cognate facilitation effect in first-language and second-language naming.

PubMed

Sheng, Li; Lam, Boji Pak Wing; Cruz, Diana; Fulton, Aislynn

2016-01-01

The cognate facilitation effect refers to the phenomenon that in bilinguals performance on various vocabulary tasks is enhanced for cross-linguistic cognates as opposed to noncognates. However, research investigating the presence of the cognate advantage in bilingual children remains limited. Most studies with children conducted to date has not included a control group or rigorously designed stimuli, which may jeopardize the validity and robustness of the emerging evidence. The current study addressed these methodological problems by examining performance in picture naming tasks in 34 4- to 7-year-old Spanish-English bilinguals and 52 Mandarin-English bilinguals as well as 37 English-speaking monolinguals who served as controls. Stimuli were controlled for phonology, word frequency, and length. The Spanish-English bilinguals performed better for cognates than for noncognates and exhibited a greater number of doublet responses (i.e., providing correct responses in both languages) in naming cognate targets than in naming noncognates. The control groups did not show differences in performance between the two sets of words. These findings provide compelling evidence that cross-linguistic similarities at the phonological level allow bootstrapping of vocabulary learning. Copyright © 2015 Elsevier Inc. All rights reserved.

Dissociation in hysteria and hypnosis: evidence from cognitive neuroscience.

PubMed

Bell, Vaughan; Oakley, David A; Halligan, Peter W; Deeley, Quinton

2011-03-01

Jean-Martin Charcot proposed the radical hypothesis that similar brain processes were responsible for the unexplained neurological symptoms of 'hysteria', now typically diagnosed as 'conversion disorder' or 'dissociative (conversion) disorder', and the temporary effects of hypnosis. While this idea has been largely ignored, recent cognitive neuroscience studies indicate that (i) hypnotisability traits are associated with a tendency to develop dissociative symptoms in the sensorimotor domain; (ii) dissociative symptoms can be modelled with suggestions in highly hypnotisable subjects; and (iii) hypnotic phenomena engage brain processes similar to those seen in patients with symptoms of hysteria. One clear theme to emerge from the findings is that 'symptom' presentation, whether clinically diagnosed or simulated using hypnosis, is associated with increases in prefrontal cortex activity suggesting that intervention by the executive system in both automatic and voluntary cognitive processing is common to both hysteria and hypnosis. Nevertheless, while the recent literature provides some compelling leads into the understanding of these phenomena, the field still lacks well controlled systematically designed studies to give a clear insight into the neurocognitive processes underlying dissociation in both hysteria and hypnosis. The aim of this review is to provide an agenda for future research.

Vocal acoustic analysis as a biometric indicator of information processing: implications for neurological and psychiatric disorders.

PubMed

Cohen, Alex S; Dinzeo, Thomas J; Donovan, Neila J; Brown, Caitlin E; Morrison, Sean C

2015-03-30

Vocal expression reflects an integral component of communication that varies considerably within individuals across contexts and is disrupted in a range of neurological and psychiatric disorders. There is reason to suspect that variability in vocal expression reflects, in part, the availability of "on-line" resources (e.g., working memory, attention). Thus, understanding vocal expression is a potentially important biometric index of information processing, not only across but within individuals over time. A first step in this line of research involves establishing a link between vocal expression and information processing systems in healthy adults. The present study employed a dual attention experimental task where participants provided natural speech while simultaneously engaged in a baseline, medium or high nonverbal processing-load task. Objective, automated, and computerized analysis was employed to measure vocal expression in 226 adults. Increased processing load resulted in longer pauses, fewer utterances, greater silence overall and less variability in frequency and intensity levels. These results provide compelling evidence of a link between information processing resources and vocal expression, and provide important information for the development of an automated, inexpensive and uninvasive biometric measure of information processing. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Enhanced NMR Discrimination of Pharmaceutically Relevant Molecular Crystal Forms through Fragment-Based Ab Initio Chemical Shift Predictions.

PubMed

Hartman, Joshua D; Day, Graeme M; Beran, Gregory J O

2016-11-02

Chemical shift prediction plays an important role in the determination or validation of crystal structures with solid-state nuclear magnetic resonance (NMR) spectroscopy. One of the fundamental theoretical challenges lies in discriminating variations in chemical shifts resulting from different crystallographic environments. Fragment-based electronic structure methods provide an alternative to the widely used plane wave gauge-including projector augmented wave (GIPAW) density functional technique for chemical shift prediction. Fragment methods allow hybrid density functionals to be employed routinely in chemical shift prediction, and we have recently demonstrated appreciable improvements in the accuracy of the predicted shifts when using the hybrid PBE0 functional instead of generalized gradient approximation (GGA) functionals like PBE. Here, we investigate the solid-state 13 C and 15 N NMR spectra for multiple crystal forms of acetaminophen, phenobarbital, and testosterone. We demonstrate that the use of the hybrid density functional instead of a GGA provides both higher accuracy in the chemical shifts and increased discrimination among the different crystallographic environments. Finally, these results also provide compelling evidence for the transferability of the linear regression parameters mapping predicted chemical shieldings to chemical shifts that were derived in an earlier study.

Enhanced NMR Discrimination of Pharmaceutically Relevant Molecular Crystal Forms through Fragment-Based Ab Initio Chemical Shift Predictions

PubMed Central

2016-01-01

Chemical shift prediction plays an important role in the determination or validation of crystal structures with solid-state nuclear magnetic resonance (NMR) spectroscopy. One of the fundamental theoretical challenges lies in discriminating variations in chemical shifts resulting from different crystallographic environments. Fragment-based electronic structure methods provide an alternative to the widely used plane wave gauge-including projector augmented wave (GIPAW) density functional technique for chemical shift prediction. Fragment methods allow hybrid density functionals to be employed routinely in chemical shift prediction, and we have recently demonstrated appreciable improvements in the accuracy of the predicted shifts when using the hybrid PBE0 functional instead of generalized gradient approximation (GGA) functionals like PBE. Here, we investigate the solid-state 13C and 15N NMR spectra for multiple crystal forms of acetaminophen, phenobarbital, and testosterone. We demonstrate that the use of the hybrid density functional instead of a GGA provides both higher accuracy in the chemical shifts and increased discrimination among the different crystallographic environments. Finally, these results also provide compelling evidence for the transferability of the linear regression parameters mapping predicted chemical shieldings to chemical shifts that were derived in an earlier study. PMID:27829821

Social control and coercion in addiction treatment: towards evidence-based policy and practice.

PubMed

Wild, T Cameron

2006-01-01

Social pressures are often an integral part of the process of seeking addiction treatment. However, scientists have not developed conclusive evidence on the processes, benefits and limitations of using legal, formal and informal social control tactics to inform policy makers, service providers and the public. This paper characterizes barriers to a robust interdisciplinary analysis of social control and coercion in addiction treatment and provides directions for future research. Conceptual analysis and review of key studies and trends in the area are used to describe eight implicit assumptions underlying policy, practice and scholarship on this topic. Many policies, programmes and researchers are guided by a simplistic behaviourist and health-service perspective on social controls that (a) overemphasizes the use of criminal justice systems to compel individuals into treatment and (b) fails to take into account provider, patient and public views. Policies and programmes that expand addiction treatment options deserve support. However, drawing a firm distinction between social controls (objective use of social pressure) and coercion (client perceptions and decision-making processes) supports a parallel position that rejects treatment policies, programmes, and associated practices that create client perceptions of coercion.

#Eduresistance: A Critical Analysis of the Role of Digital Media in Collective Struggles for Public Education in the Usa

ERIC Educational Resources Information Center

Thapliyal, Nisha

2018-01-01

From Facebook-coordinated high-school walkouts to compelling Internet-based protest art that has accompanied recent teacher strikes, grassroots education activism in the USA has gone digital. Despite the proliferation of research on the mediatisation of education policy, few studies have explored the ways in which activists for public education…

The Role of "Family Snapshots" in Teaching Art History within a Dialogic Pedagogy

ERIC Educational Resources Information Center

Baxter, Kristin

2012-01-01

Studying images of families in works of art and in snapshots is compelling, and the author wondered if looking at both types of images side by side might help students understand both kinds of images more fully. Snapshots often prompt detailed and vivid stories among family members and friends. Therefore, she wondered if dialogue about snapshots…

Standing in the middle: Insider/outsider positionality while conducting qualitative research with opposing military veteran political groups

Treesearch

David Flores

2018-01-01

This case study describes the process and challenges of conducting qualitative research on two opposing military veteran political groups: Iraq Veterans Against the War and Vets for Freedom. The discussion is based on a dissertation project that compelled me to reflect on my simultaneous "insider" status as a military veteran and "outsider" status...

Digital Storytelling in a Place-Based Composition Course

ERIC Educational Resources Information Center

Chisholm, James S.; Trent, Brandie

2014-01-01

Although the study of place in the fields of composition and education has a long and compelling history, the concept has taken on increased importance in today's digital landscape. As perceptions of places shift, we're challenged to understand how and which places shape who we are. Due to its potential power to leverage student choice,…

On a Path to Success: Experiences of Hispanic High School Dropout Students

ERIC Educational Resources Information Center

Garza, Jorge L.

2010-01-01

This study is about the lives of three low-socioeconomic Hispanic students who dropped out of high school and felt compelled to return to the school setting to earn their high school diploma. This research focused on one research question: What are the life experiences of low socio-economic Hispanic students who successfully graduated from high…

Historical Research and Research in Higher Education: Reflections and Recommendations from a Self-Study

ERIC Educational Resources Information Center

Haigh, Neil

2012-01-01

When we conceptualize and undertake new research projects, a number of the associated activities require us to take on the role of an historian: there is historical research to do. Those activities include determining whether there is a compelling case for embarking on the project in the light of previous research, making design decisions that…

Twin Data That Made a Big Difference, and That Deserve to Be Better-Known and Used in Teaching

ERIC Educational Resources Information Center

Campbell, Harlan; Hanley, James A.

2017-01-01

Because of their efficiency and ability to keep many other factors constant, twin studies have a special appeal for investigators. Just as with any teaching dataset, a "matched-sets" dataset used to illustrate a statistical model should be compelling, still relevant, and valid. Indeed, such a "model dataset" should meet the…

When Compelled to FB around Academic Texts: Postgraduate Students Reflected on Their Online Experience

ERIC Educational Resources Information Center

Abdullah, Sarimah Shaik; Yaacob, Aizan; Rahim, Fauziah Abdul

2013-01-01

Purpose: This paper is part of a larger study which explored postgraduate students talk around academic texts via Facebook (FB). Our exploration is largely guided by the idea of reading as a social practice. In this paper, we specifically focus on the students' reflections of their online experience of talking around academic texts. Method: The…

Heart Rate Recovery and Variability Following Combined Aerobic and Resistance Exercise Training in Adults with and without Down Syndrome

ERIC Educational Resources Information Center

Mendonca, Goncalo V.; Pereira, Fernando D.; Fernhall, Bo

2013-01-01

Persons with Down syndrome (DS) are at high risk for cardiovascular morbidity and mortality, and there is compelling evidence of autonomic dysfunction in these individuals. The main purpose of this study was to determine whether a combined aerobic and resistance exercise intervention produces similar results in cardiac autonomic function between…

Who Gets to Be a Writer? Exploring Identity and Learning Issues in Becoming a Fiction Author

ERIC Educational Resources Information Center

Gouthro, Patricia A.

2014-01-01

Drawing upon a research study on lifelong learning, citizenship, and fiction writing, this paper explores issues around identity and learning in becoming a fiction author. Five main thematic areas are discussed: (1) envisioning a writing career, (2) compelled to write, (3) learning the craft, (4) getting published, and (5) online identity. The…

"I'm Still Here:" Black Female Undergraduates' Self-Definition Narratives

ERIC Educational Resources Information Center

Robinson, Subrina J.; Esquibel, Elena; Rich, Marc D.

2013-01-01

Drawing on Black feminism and oral narrative research, we examine how Black women undergraduates make sense of their identities as Black females. More specifically, we explore the dual impact of gender and race by considering what it means to be a Black woman on campus. The women in this study articulate compelling, and at times, diverging…

Compelled to Be Connected: An Ethnographic Exploration of Organizational Culture, Work-Life Balance, and the Use of Mobile Workplace Technologies

ERIC Educational Resources Information Center

Thomas, Kristopher J.

2013-01-01

This study is an ethnographic exploration of organizational culture, work-life balance, and the use of information and communication technology ("ICT") in the work and home settings. The researcher was embedded for nine weeks within the Information Technology ("IT") department at the corporate headquarters of a mid-sized…

Pre-Service Teachers' Impact on Student Learning: Three-Year Study of the Impact on Student Learning Project

ERIC Educational Resources Information Center

Meister, Denise G.

2011-01-01

With the demand for a demonstration of continuous progress as an accountability gauge in public schools, teachers are compelled to examine assessment data for each of their pupils. This data analysis, in turn, should help teachers gauge their instructional practices and differentiate instruction so that all can reach proficient levels of…

Skype-Based English Activities: A Case for Compelling Input? Correlational Changes before and after Skype Exchanges

ERIC Educational Resources Information Center

Ockert, David

2015-01-01

This paper reports the results of a small, longitudinal study involving a group of Japanese elementary school students (N = 29) involved in exploratory research using foreign language activities, including two Skype exchanges between these students and students in Australia. The purpose of the research was to test for the impact of a series of…

Where Does the Teaching of Advertising Belong?: The Case for the Business School Environment. Faculty Working Paper No. MK 78-28.

ERIC Educational Resources Information Center

Patti, Charles H.

Compelling arguments have been offered supporting both the journalism/ communication school and the business school as the ideal setting for advertising education. While relatively few advertising programs now exist in business schools, a growing number of undergraduates are finding the study of advertising in a business school environment to be…

Response to Comartin, Kernsmith, and Miles' (2010) Michigan Sex Offender Registration Study

ERIC Educational Resources Information Center

Prescott, David S.

2010-01-01

Basic human respect compels everyone to ask about the effect of the current policies to prevent further abuse on family members of those who have abused. Sadly, only a handful of researchers are examining the effects of policies on the affected parties, such as victims, the abusers themselves, or their families. No one yet has asked a random…

Hypertonic Saline Resuscitation Restores Inflammatory Cytokine Balance in Post-Traumatic Hemorrhagic Shock Patients

DTIC Science & Technology

2004-08-01

immunocompetant cells experience bidirectional communication with hormones and cytokines [35,40]. Thus, despite compelling experimental findings, HSD has not...hypertonic saline with 6% dextran-70 (HSD) has been shown in experimental studies to reduce shock/resuscitation-induced inflammatory reactions and...alterations have been described in clinical and experimental investigations of post-traumatic hemorrhagic shock [13]. The initial immunological

Leonard Covello: A Study of Progressive Leadership and Community Empowerment. Occasional Paper Series 24

ERIC Educational Resources Information Center

Krakowsky, Lorenzo

2010-01-01

This paper tells the remarkable and compelling story of Leonard Covello, a ground breaking progressive educator who worked tirelessly to shape public education in New York City during the first half of the 20th century. Covello was the founding principal of Benjamin Franklin High School (BFHS) in East Harlem in the 1930s. The author invites…

[The potential contribution of adenovirus 36 to the development of obesity].

PubMed

Villavicencio, Francisca; Valladares, Macarena

2017-08-01

The evidence of the last 20 years shows a link between viral infections and obesity in animals and humans. There are five adenovirus which have been associated with development of obesity in animals. SMAM-1 virus was the first studied in humans associated with obesity. There is compelling evidence that Ad-36 virus could contribute to the development of obesity in humans and it is related with body mass index (BMI). This manuscript reviews the association between Ad-36 and the other four virus infections with obesity. An electronic search of articles in the databases PubMed and Scielo, with use of key words: obesity, infection, adipose tissue, Ad-36, 3T3-L1 was performed. The search was restricted "human" and "animals". The importance of the relationship between virus infections and obesity has increased over the past two decades. Ad-36 shows more compelling evidence in humans. There are reports involving this virus in the enhancement of adipogenesis, adipocyte differentiation, a lower secretion of leptin and an increased insulin sensitivity. Future work should focus in larger cohort studies to confirm this association, which explains the global obesity epidemic from a new perspective.

Rigor, vigor, and the study of health disparities

PubMed Central

Adler, Nancy; Bush, Nicole R.; Pantell, Matthew S.

2012-01-01

Health disparities research spans multiple fields and methods and documents strong links between social disadvantage and poor health. Associations between socioeconomic status (SES) and health are often taken as evidence for the causal impact of SES on health, but alternative explanations, including the impact of health on SES, are plausible. Studies showing the influence of parents’ SES on their children’s health provide evidence for a causal pathway from SES to health, but have limitations. Health disparities researchers face tradeoffs between “rigor” and “vigor” in designing studies that demonstrate how social disadvantage becomes biologically embedded and results in poorer health. Rigorous designs aim to maximize precision in the measurement of SES and health outcomes through methods that provide the greatest control over temporal ordering and causal direction. To achieve precision, many studies use a single SES predictor and single disease. However, doing so oversimplifies the multifaceted, entwined nature of social disadvantage and may overestimate the impact of that one variable and underestimate the true impact of social disadvantage on health. In addition, SES effects on overall health and functioning are likely to be greater than effects on any one disease. Vigorous designs aim to capture this complexity and maximize ecological validity through more complete assessment of social disadvantage and health status, but may provide less-compelling evidence of causality. Newer approaches to both measurement and analysis may enable enhanced vigor as well as rigor. Incorporating both rigor and vigor into studies will provide a fuller understanding of the causes of health disparities. PMID:23045672

Graphic Narratives and Cancer Prevention: A Case Study of an American Cancer Society Comic Book.

PubMed

Krakow, Melinda

2017-05-01

As the interest in graphic medicine grows, health communicators have started engaging readers with compelling visual and textual accounts of health and illness, including via comic books. One context where comics have shown promise is cancer communication. This brief report presents an early example of graphic medicine developed by the American Cancer Society. "Ladies … Wouldn't It Be Better to Know?" is a comic book produced in the 1960s to provide the public with lay information about the Pap test for cervical cancer prevention and detection. An analysis of a key narrative attribute, plot development, illustrates the central role that perceived barriers played in this midcentury public health message, a component that remains a consideration of cancer communication design today. This case study of an early graphic narrative identifies promising cancer message features that can be used to address and refute barriers to cervical cancer screening and connects contemporary research with historical efforts in public health communication.

Enhancement of cognitive and neural functions through complex reasoning training: evidence from normal and clinical populations

PubMed Central

Chapman, Sandra B.; Mudar, Raksha A.

2014-01-01

Public awareness of cognitive health is fairly recent compared to physical health. Growing evidence suggests that cognitive training offers promise in augmenting cognitive brain performance in normal and clinical populations. Targeting higher-order cognitive functions, such as reasoning in particular, may promote generalized cognitive changes necessary for supporting the complexities of daily life. This data-driven perspective highlights cognitive and brain changes measured in randomized clinical trials that trained gist reasoning strategies in populations ranging from teenagers to healthy older adults, individuals with brain injury to those at-risk for Alzheimer's disease. The evidence presented across studies support the potential for Gist reasoning training to strengthen cognitive performance in trained and untrained domains and to engage more efficient communication across widespread neural networks that support higher-order cognition. The meaningful benefits of Gist training provide compelling motivation to examine optimal dose for sustained benefits as well as to explore additive benefits of meditation, physical exercise, and/or improved sleep in future studies. PMID:24808834

Early but not late-blindness leads to enhanced auditory perception.

PubMed

Wan, Catherine Y; Wood, Amanda G; Reutens, David C; Wilson, Sarah J

2010-01-01

The notion that blindness leads to superior non-visual abilities has been postulated for centuries. Compared to sighted individuals, blind individuals show different patterns of brain activation when performing auditory tasks. To date, no study has controlled for musical experience, which is known to influence auditory skills. The present study tested 33 blind (11 congenital, 11 early-blind, 11 late-blind) participants and 33 matched sighted controls. We showed that the performance of blind participants was better than that of sighted participants on a range of auditory perception tasks, even when musical experience was controlled for. This advantage was observed only for individuals who became blind early in life, and was even more pronounced for individuals who were blind from birth. Years of blindness did not predict task performance. Here, we provide compelling evidence that superior auditory abilities in blind individuals are not explained by musical experience alone. These results have implications for the development of sensory substitution devices, particularly for late-blind individuals.

Altered Cytochrome c Display Precedes Apoptotic Cell Death in Drosophila

PubMed Central

Varkey, Johnson; Chen, Po; Jemmerson, Ronald; Abrams, John M.

1999-01-01

Drosophila affords a genetically well-defined system to study apoptosis in vivo. It offers a powerful extension to in vitro models that have implicated a requirement for cytochrome c in caspase activation and apoptosis. We found that an overt alteration in cytochrome c anticipates programmed cell death (PCD) in Drosophila tissues, occurring at a time that considerably precedes other known indicators of apoptosis. The altered configuration is manifested by display of an otherwise hidden epitope and occurs without release of the protein into the cytosol. Conditional expression of the Drosophila death activators, reaper or grim, provoked apoptogenic cytochrome c display and, surprisingly, caspase activity was necessary and sufficient to induce this alteration. In cell-free studies, cytosolic caspase activation was triggered by mitochondria from apoptotic cells but identical preparations from healthy cells were inactive. Our observations provide compelling validation of an early role for altered cytochrome c in PCD and suggest propagation of apoptotic physiology through reciprocal, feed-forward amplification involving cytochrome c and caspases. PMID:10037791

State of the art metrics for aspect oriented programming

NASA Astrophysics Data System (ADS)

Ghareb, Mazen Ismaeel; Allen, Gary

2018-04-01

The quality evaluation of software, e.g., defect measurement, gains significance with higher use of software applications. Metric measurements are considered as the primary indicator of imperfection prediction and software maintenance in various empirical studies of software products. However, there is no agreement on which metrics are compelling quality indicators for novel development approaches such as Aspect Oriented Programming (AOP). AOP intends to enhance programming quality, by providing new and novel constructs for the development of systems, for example, point cuts, advice and inter-type relationships. Hence, it is not evident if quality pointers for AOP can be derived from direct expansions of traditional OO measurements. Then again, investigations of AOP do regularly depend on established coupling measurements. Notwithstanding the late reception of AOP in empirical studies, coupling measurements have been adopted as useful markers of flaw inclination in this context. In this paper we will investigate the state of the art metrics for measurement of Aspect Oriented systems development.

Hereditary association between testicular cancer and familial ovarian cancer: A Familial Ovarian Cancer Registry study.

PubMed

Etter, John Lewis; Eng, Kevin; Cannioto, Rikki; Kaur, Jasmine; Almohanna, Hani; Alqassim, Emad; Szender, J Brian; Joseph, Janine M; Lele, Shashikant; Odunsi, Kunle; Moysich, Kirsten B

2018-04-01

Although family history of testicular cancer is well-established as a risk factor for testicular cancer, it is unknown whether family history of ovarian cancer is associated with risk of testicular cancer. Using data from the Familial Ovarian Cancer Registry on 2636 families with multiple cases of ovarian cancer, we systematically compared relative frequencies of ovarian cancer among relatives of men with testicular and non-testicular cancers. Thirty-one families with cases of both ovarian and testicular cancer were identified. We observed that, among men with cancer, those with testicular cancer were more likely to have a mother with ovarian cancer than those with non-testicular cancers (OR = 3.32, p = 0.004). Zero paternal grandmothers of men with testicular cancer had ovarian cancer. These observations provide compelling preliminary evidence for a familial association between ovarian and testicular cancers Future studies should be designed to further investigate this association and evaluate X-linkage. Copyright © 2018 Elsevier Ltd. All rights reserved.