76 FR 22615 - Privacy Act; Implementation
Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-22
... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DoD-2011-OS-0003] 32 CFR Part 322... Part 322 Privacy. Accordingly, 32 CFR part 322 is amended as follows: PART 322--NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICE PROGRAM 0 1. The authority citation for 32 CFR part 322.7 continues to...
76 FR 22614 - Privacy Act; Implementation
Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-22
... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DoD-2008-OS-0053] 32 CFR Part 322... levels of government. List of Subjects in 32 CFR Part 322 Privacy. Accordingly, 32 CFR part 322 is amended as follows: PART 322--[AMENDED] 0 1. The authority citation for 32 CFR part 322 continues to read...
77 FR 15596 - Privacy Act; Implementation
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-16
... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DoD-2012-OS-0032] 32 CFR Part 322 Privacy... levels of government. List of Subjects in 32 CFR Part 322 Privacy. Accordingly, 32 CFR part 322 is amended as follows: PART 322--NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICE 0 1. The authority...
New decoding methods of interleaved burst error-correcting codes
NASA Astrophysics Data System (ADS)
Nakano, Y.; Kasahara, M.; Namekawa, T.
1983-04-01
A probabilistic method of single burst error correction, using the syndrome correlation of subcodes which constitute the interleaved code, is presented. This method makes it possible to realize a high capability of burst error correction with less decoding delay. By generalizing this method it is possible to obtain probabilistic method of multiple (m-fold) burst error correction. After estimating the burst error positions using syndrome correlation of subcodes which are interleaved m-fold burst error detecting codes, this second method corrects erasure errors in each subcode and m-fold burst errors. The performance of these two methods is analyzed via computer simulation, and their effectiveness is demonstrated.
77 FR 19095 - Privacy Act; Implementation; Correction
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-30
... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2012-OS-0031] 32 CFR Part 322... direct final rule, Department of Defense discovered that paragraphs (l)(2) through (l)(5) in Sec. 322.7...) published on March 16, 2012 (77 FR 15595-15596), make the following corrections: Sec. 322.7 [Corrected] On...
NASA Technical Reports Server (NTRS)
Lin, Shu (Principal Investigator); Uehara, Gregory T.; Nakamura, Eric; Chu, Cecilia W. P.
1996-01-01
The (64, 40, 8) subcode of the third-order Reed-Muller (RM) code for high-speed satellite communications is proposed. The RM subcode can be used either alone or as an inner code of a concatenated coding system with the NASA standard (255, 233, 33) Reed-Solomon (RS) code as the outer code to achieve high performance (or low bit-error rate) with reduced decoding complexity. It can also be used as a component code in a multilevel bandwidth efficient coded modulation system to achieve reliable bandwidth efficient data transmission. The progress made toward achieving the goal of implementing a decoder system based upon this code is summarized. The development of the integrated circuit prototype sub-trellis IC, particularly focusing on the design methodology, is addressed.
A novel encoding scheme for effective biometric discretization: Linearly Separable Subcode.
Lim, Meng-Hui; Teoh, Andrew Beng Jin
2013-02-01
Separability in a code is crucial in guaranteeing a decent Hamming-distance separation among the codewords. In multibit biometric discretization where a code is used for quantization-intervals labeling, separability is necessary for preserving distance dissimilarity when feature components are mapped from a discrete space to a Hamming space. In this paper, we examine separability of Binary Reflected Gray Code (BRGC) encoding and reveal its inadequacy in tackling interclass variation during the discrete-to-binary mapping, leading to a tradeoff between classification performance and entropy of binary output. To overcome this drawback, we put forward two encoding schemes exhibiting full-ideal and near-ideal separability capabilities, known as Linearly Separable Subcode (LSSC) and Partially Linearly Separable Subcode (PLSSC), respectively. These encoding schemes convert the conventional entropy-performance tradeoff into an entropy-redundancy tradeoff in the increase of code length. Extensive experimental results vindicate the superiority of our schemes over the existing encoding schemes in discretization performance. This opens up possibilities of achieving much greater classification performance with high output entropy.
Ground-state coding in partially connected neural networks
NASA Technical Reports Server (NTRS)
Baram, Yoram
1989-01-01
Patterns over (-1,0,1) define, by their outer products, partially connected neural networks, consisting of internally strongly connected, externally weakly connected subnetworks. The connectivity patterns may have highly organized structures, such as lattices and fractal trees or nests. Subpatterns over (-1,1) define the subcodes stored in the subnetwork, that agree in their common bits. It is first shown that the code words are locally stable stares of the network, provided that each of the subcodes consists of mutually orthogonal words or of, at most, two words. Then it is shown that if each of the subcodes consists of two orthogonal words, the code words are the unique ground states (absolute minima) of the Hamiltonian associated with the network. The regions of attraction associated with the code words are shown to grow with the number of subnetworks sharing each of the neurons. Depending on the particular network architecture, the code sizes of partially connected networks can be vastly greater than those of fully connected ones and their error correction capabilities can be significantly greater than those of the disconnected subnetworks. The codes associated with lattice-structured and hierarchical networks are discussed in some detail.
Circuit Design Approaches for Implementation of a Subtrellis IC for a Reed-Muller Subcode
NASA Technical Reports Server (NTRS)
Lin, Shu; Uehara, Gregory T.; Nakamura, Eric B.; Chu, Cecilia W. P.
1996-01-01
In his research, we have proposed the (64, 40, 8) subcode of the third-order Reed-Muller (RM) code to NASA for high-speed satellite communications. This RM subcode can be used either alone or as an inner code of a concatenated coding system with the NASA standard (255, 233, 33) Reed-Solomon (RS) code as the outer code to achieve high performance (or low bit-error rate) with reduced decoding complexity. It can also be used as a component code in a multilevel bandwidth efficient coded modulation system to achieve reliable bandwidth efficient data transmission. This report will summarize the key progress we have made toward achieving our eventual goal of implementing a decoder system based upon this code. In the first phase of study, we investigated the complexities of various sectionalized trellis diagrams for the proposed (64, 40, 8) RM subcode. We found a specific 8-trellis diagram for this code which requires the least decoding complexity with a high possibility of achieving a decoding speed of 600 M bits per second(Mbps). The combination of a large number of states and a high data rate will be made possible due to the utilization of a high degree of parallelism throughout the architecture. This trellis diagram will be presented and briefly described. In the second phase of study which was carried out through the past year, we investigated circuit architectures to determine the feasibility of VLSI implementation of a high- speed Viterbi decoder based on this 8-section trellis diagram. We began to examine specific design and implementation approaches to implement a fully custom integrated circuit (IC) which will be a key building block for a decoder system implementation. The key results will be presented in this report. This report will be divided into three primary sections. First, we will briefly describe the system block diagram in which the proposed decoder is assumed to be operating and present some of the key architectural approaches being used to implement the system at high speed. Second, we will describe details of the 8-trellis diagram we found to best meet the trade-offs between chip and overall system complexity. The chosen approach implements the trellis for the (64, 40, 8) RM subcode with 32 independent sub-trellises. And third, we will describe results of our feasibility study on the implementation of such an IC chip in CMOS technology to implement one of these subtrellises.
Circuit Design Approaches for Implementation of a Subtrellis IC for a Reed-Muller Subcode
NASA Technical Reports Server (NTRS)
Lin, Shu; Uehara, Gregory T.; Nakamura, Eric B.; Chu, Cecilia W. P.
1996-01-01
In this research, we have proposed the (64, 40, 8) subcode of the third-order Reed-Muller (RM) code to NASA for high-speed satellite communications. This RM subcode can be used either alone or as an inner code of a concatenated coding system with the NASA standard (255, 233, 33) Reed-Solomon (RS) code as the outer code to achieve high performance (or low bit-error rate) with reduced decoding complexity. It can also be used as a component code in a multilevel bandwidth efficient coded modulation system to achieve reliable bandwidth efficient data transmission. This report will summarize the key progress we have made toward achieving our eventual goal of implementing a decoder system based upon this code. In the first phase of study, we investigated the complexities of various sectionalized trellis diagrams for the proposed (64, 40, 8) RM subcode. We found a specific 8-trellis diagram for this code which requires the least decoding complexity with a high possibility of achieving a decoding speed of 600 M bits per second (Mbps). The combination of a large number of states and a high data rate will be made possible due to the utilization of a high degree of parallelism throughout the architecture. This trellis diagram will be presented and briefly described. In the second phase of study which was carried out through the past year, we investigated circuit architectures to determine the feasibility of VLSI implementation of a high-speed Viterbi decoder based on this 8-section trellis diagram. We began to examine specific design and implementation approaches to implement a fully custom integrated circuit (IC) which will be a key building block for a decoder system implementation. The key results will be presented in this report. This report will be divided into three primary sections. First, we will briefly describe the system block diagram in which the proposed decoder is assumed to be operating and present some of the key architectural approaches being used to implement the system at high speed. Second, we will describe details of the 8-trellis diagram we found to best meet the trade-offs between chip and overall system complexity. The chosen approach implements the trellis for the (64, 40, 8) RM subcode with 32 independent sub-trellises. And third, we will describe results of our feasibility study on the implementation of such an IC chip in CMOS technology to implement one of these subtrellises.
Fake ID ownership and heavy drinking in underage college students: prospective findings.
Martinez, Julia A; Rutledge, Patricia C; Sher, Kenneth J
2007-06-01
The authors examined the ownership of false identification (fake ID) for the purpose of obtaining alcohol and the relation of fake ID ownership to heavy drinking in a longitudinal sample of college students under 21 years of age. A sample of 3,720 undergraduates was assessed the summer prior to college entrance and during the 4 semesters comprising freshman and sophomore years. Regression analyses were used to estimate bidirectional relations between consumption and fake ID ownership. Sex, Greek membership, and prior drinking were controlled. Results showed that fake ID ownership increased over time (12.5% pre-college to 32.2% fourth semester) and that Greek members were more likely than others to own fake IDs. Fake ID ownership predicted concurrent and next-semester heavy drinking with increasing strength over time. Also, the acquisition (onset) of fake ID ownership at each time point was predicted by previous-semester consumption. When traditional, robust risk factors of consumption are controlled, fake ID ownership meaningfully relates to heavy drinking in college. It thus presents a significant public health problem, addressable through training for alcohol servers and retailers, punitive measures toward fake ID owners, and other possible interventions.
Powell, Shelagh; Koch, Susanne V; Crowley, James J; Matthiesen, Manuel; Grice, Dorothy E; Thomsen, Per H; Parner, E
2017-01-01
Objectives Employing national registers for research purposes depends on a high diagnostic validity. The aim of the present study was to examine the diagnostic validity of recorded diagnoses of early-onset obsessive-compulsive disorder (OCD) in the Danish Psychiatric Central Register (DPCR). Design Review of patient journals selected randomly through the DPCR. Method One hundred cases of OCD were randomly selected from DPCR. Using a predefined coding scheme based on the Children’s Yale Brown Obsessive Compulsive Scale (CYBOCS), experienced research nurse or child and adolescent psychiatrists assessed each journal to determine the presence/absence of OCD diagnostic criteria. The detailed assessments were reviewed by two senior child and adolescent psychiatrists to determine if diagnostic criteria were met. Primary outcome measurements Positive predictive value (PPV) was used as the primary outcome measurement. Results A total of 3462 children/adolescents received an OCD diagnosis as the main diagnosis between 1 January 1995 and 31 December 2015. The average age at diagnosis was 13.21±2.89 years. The most frequent registered OCD subcode was the combined diagnosis DF42.2. Of the 100 cases we examined, 35 had at least one registered comorbidity. For OCD, the PPV was good (PPV 0.85). Excluding journals with insufficient information, the PPV was 0.96. For the subcode F42.2 the PPV was 0.77. The inter-rater reliability was 0.94. The presence of the CYBOCS in the journal significantly increased the PPV for the OCD diagnosis altogether and for the subcode DF42.2. Conclusion The validity and reliability of International Classification of Disease 10th revision codes for OCD in the DPCR is generally high. The subcodes for predominant obsessions/predominant compulsions are less certain and should be used with caution. The results apply for both children and adolescents and for both older and more recent cases. Altogether, the study suggests that there is a high validity of the OCD diagnosis in the Danish National Registers. PMID:28928194
41. ARAIII Prototype assembly and evaluation building ARA630. West end ...
41. ARA-III Prototype assembly and evaluation building ARA-630. West end and south side of building. Camera facing northeast. Ineel photo no. 3-22. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID
NASA Astrophysics Data System (ADS)
Earle, Sarah
2014-05-01
Background:Since the discontinuation of Standard Attainment Tests (SATs) in science at age 11 in England, pupil performance data in science reported to the UK government by each primary school has relied largely on teacher assessment undertaken in the classroom. Purpose:The process by which teachers are making these judgements has been unclear, so this study made use of the extensive Primary Science Quality Mark (PSQM) database to obtain a 'snapshot' (as of March 2013) of the approaches taken by 91 English primary schools to the formative and summative assessment of pupils' learning in science.
Tumor-Selective Targeting of Androgen Receptor Expression by Novel Small-Molecule Agents
2013-05-01
Uro - genital...Mouse ID 310 315 316 322 331 302 307 309 318 333 PCNA β-Actin Mouse ID PCNA β-Actin OSU-CG5 CG5Ctl CG5 Ctl P = 0.002 Control D o rs al lo b e % R el...e xp re ss io n % C el ls im m u n o re ac ti ve fo r K i6 7 L at er al lo b e OSU-CG5 DP * * * * *P < 0.05 LP VP AP Figure 3.
IRA: Intrusion - Reaction - Appats
2004-11-01
deuxième phase fut de mettre en œuvre un IDS au sein d’une plate-forme de tests afin d’en présenter les différents aspects. Les trois ...local et / ou distant vers le Responsable SSI 4 / Analyse 3.2.2 Modes d’action des IDS Trois modes d’actions sont caractéristiques des outils de...et la capture des informations. La figure suivante montre ce que pourrait être un honeynet. Trois réseaux séparés par un pare-feu : l’Internet
IET. Control and equipment building (TAN620). Details and room finish ...
IET. Control and equipment building (TAN-620). Details and room finish schedule. Ralph M. Parsons 902-4-ANP-620-A 322. Approved by INEEL Classification Office for public release. INEEL index code no. 035-0629-00-693-106907 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID
High-Speed Soft-Decision Decoding of Two Reed-Muller Codes
NASA Technical Reports Server (NTRS)
Lin, Shu; Uehara, Gregory T.
1996-01-01
In his research, we have proposed the (64, 40, 8) subcode of the third-order Reed-Muller (RM) code to NASA for high-speed satellite communications. This RM subcode can be used either alone or as an inner code of a concatenated coding system with the NASA standard (255, 233, 33) Reed-Solomon (RS) code as the outer code to achieve high performance (or low bit-error rate) with reduced decoding complexity. It can also be used as a component code in a multilevel bandwidth efficient coded modulation system to achieve reliable bandwidth efficient data transmission. This report will summarize the key progress we have made toward achieving our eventual goal of implementing a decoder system based upon this code. In the first phase of study, we investigated the complexities of various sectionalized trellis diagrams for the proposed (64, 40, 8) RNI subcode. We found a specific 8-trellis diagram for this code which requires the least decoding complexity with a high possibility of achieving a decoding speed of 600 M bits per second (Mbps). The combination of a large number of states and a hi ch data rate will be made possible due to the utilization of a high degree of parallelism throughout the architecture. This trellis diagram will be presented and briefly described. In the second phase of study which was carried out through the past year, we investigated circuit architectures to determine the feasibility of VLSI implementation of a high-speed Viterbi decoder based on this 8-section trellis diagram. We began to examine specific design and implementation approaches to implement a fully custom integrated circuit (IC) which will be a key building block for a decoder system implementation. The key results will be presented in this report. This report will be divided into three primary sections. First, we will briefly describe the system block diagram in which the proposed decoder is assumed to be operating and present some of the key architectural approaches being used to implement the system at high speed. Second, we will describe details of the 8-trellis diagram we found to best meet the trade-offs between chip and overall system complexity. The chosen approach implements the trellis for the (64, 40, 8) RM subcode with 32 independent sub-trellises. And third, we will describe results of our feasibility study on the implementation of such an IC chip in CMOS technology to implement one of these sub-trellises.
High-Speed Soft-Decision Decoding of Two Reed-Muller Codes
NASA Technical Reports Server (NTRS)
Lin, Shu; Uehara, Gregory T.
1996-01-01
In this research, we have proposed the (64, 40, 8) subcode of the third-order Reed-Muller (RM) code to NASA for high-speed satellite communications. This RM subcode can be used either alone or as an inner code of a concatenated coding system with the NASA standard (255, 233, 33) Reed-Solomon (RS) code as the outer code to achieve high performance (or low bit-error rate) with reduced decoding complexity. It can also be used as a component code in a multilevel bandwidth efficient coded modulation system to achieve reliable bandwidth efficient data transmission. This report will summarize the key progress we have made toward achieving our eventual goal of implementing, a decoder system based upon this code. In the first phase of study, we investigated the complexities of various sectionalized trellis diagrams for the proposed (64, 40, 8) RM subcode. We found a specific 8-trellis diagram for this code which requires the least decoding complexity with a high possibility of achieving a decoding speed of 600 M bits per second (Mbps). The combination of a large number of states and a high data rate will be made possible due to the utilization of a high degree of parallelism throughout the architecture. This trellis diagram will be presented and briefly described. In the second phase of study, which was carried out through the past year, we investigated circuit architectures to determine the feasibility of VLSI implementation of a high-speed Viterbi decoder based on this 8-section trellis diagram. We began to examine specific design and implementation approaches to implement a fully custom integrated circuit (IC) which will be a key building block for a decoder system implementation. The key results will be presented in this report. This report will be divided into three primary sections. First, we will briefly describe the system block diagram in which the proposed decoder is assumed to be operating, and present some of the key architectural approaches being used to implement the system at high speed. Second, we will describe details of the 8-trellis diagram we found to best meet the trade-offs between chip and overall system complexity. The chosen approach implements the trellis for the (64, 40, 8) RM subcode with 32 independent sub-trellises. And third, we will describe results of our feasibility study on the implementation of such an IC chip in CMOS technology to implement one of these sub-trellises.
Xu, Jing; Gattacceca, Florence; Amiji, Mansoor
2013-01-01
The objective of this study was to evaluate qualitative and quantitative biodistribution of epidermal growth factor receptor (EGFR)-targeted thiolated type B gelatin nanoparticles in vivo in a subcutaneous human pancreatic adenocarcinoma (Panc-1) bearing female SCID Beige mice. EGFR-targeted nanoparticles showed preferential and sustained accumulation in the tumor mass, especially at early time points. Higher blood concentrations and higher tumor accumulations were observed with PEG-modified and EGFR-targeted nanoparticles during the study (AUClast: 17.38 and 19.56 %ID/mL*h in blood, 187 and 322 %ID/g*h in tumor for PEG-modified and EGFR-targeted nanoparticles, respectively), as compared to control, unmodified particles (AUClast: 10.71 %ID/mL*h in blood and 138 %ID/g*h in tumor). EGFR-targeted nanoparticles displayed almost twice tumor targeting efficiency than either PEG-modified or the unmodified nanoparticles, highlighting the efficacy of the active targeting strategy. In conclusion, this study shows that EGFR-targeted and PEG-modified nanoparticles were suitable vehicles for specific systemic delivery in subcutaneous Panc-1 tumor xenograft models. PMID:23544877
Parallel Subspace Subcodes of Reed-Solomon Codes for Magnetic Recording Channels
ERIC Educational Resources Information Center
Wang, Han
2010-01-01
Read channel architectures based on a single low-density parity-check (LDPC) code are being considered for the next generation of hard disk drives. However, LDPC-only solutions suffer from the error floor problem, which may compromise reliability, if not handled properly. Concatenated architectures using an LDPC code plus a Reed-Solomon (RS) code…
Xu, Jing; Gattacceca, Florence; Amiji, Mansoor
2013-05-06
The objective of this study was to evaluate qualitative and quantitative biodistribution of epidermal growth factor receptor (EGFR)-targeted thiolated type B gelatin nanoparticles in vivo in subcutaneous human pancreatic adenocarcinoma (Panc-1) bearing female SCID Beige mice. EGFR-targeted nanoparticles showed preferential and sustained accumulation in the tumor mass, especially at early time points. Higher blood concentrations and higher tumor accumulations were observed with PEG-modified and EGFR-targeted nanoparticles during the study (AUClast: 17.38 and 19.56%ID/mL·h in blood, 187 and 322%ID/g·h in tumor for PEG-modified and EGFR-targeted nanoparticles, respectively), as compared to control, unmodified particles (AUClast: 10.71%ID/mL·h in blood and 138%ID/g·h in tumor). EGFR-targeted nanoparticles displayed almost twice tumor targeting efficiency than either PEG-modified or the unmodified nanoparticles, highlighting the efficacy of the active targeting strategy. In conclusion, this study shows that EGFR-targeted and PEG-modified nanoparticles were suitable vehicles for specific systemic delivery in subcutaneous Panc-1 tumor xenograft models.
A Recommender System in the Cyber Defense Domain
2014-03-27
monitoring software is a java based program sending updates to the database on the sensor machine. The host monitoring program gathers information about...3.2.2 Database. A MySQL database located on the sensor machine acts as the storage for the sensors on the network. Snort, Nmap, vulnerability scores, and...machine with the IDS and the recommender is labeled “sensor”. The recommender system code is written in java and compiled using java version 1.6.024
Kuroda, Yukiko; Ohashi, Ikuko; Naruto, Takuya; Ida, Kazumi; Enomoto, Yumi; Saito, Toshiyuki; Nagai, Jun-Ichi; Wada, Takahito; Kurosawa, Kenji
2015-06-01
Next-generation sequencing has enabled the screening for a causative mutation in X-linked intellectual disability (XLID). We identified KIAA2022 mutations in two unrelated male patients by targeted sequencing. We selected 13 Japanese male patients with severe intellectual disability (ID), including four sibling patients and nine sporadic patients. Two of thirteen had a KIAA2022 mutation. Patient 1 was a 3-year-old boy. He had severe ID with autistic behavior and hypotonia. Patient 2 was a 5-year-old boy. He also had severe ID with autistic behavior, hypotonia, central hypothyroidism, and steroid-dependent nephrotic syndrome. Both patients revealed consistent distinctive features, including upswept hair, narrow forehead, downslanting eyebrows, wide palpebral fissures, long nose, hypoplastic alae nasi, open mouth, and large ears. De novo KIAA2022 mutations (p.Q705X in Patient 1, p.R322X in Patient 2) were detected by targeted sequencing and confirmed by Sanger sequencing. KIAA2022 mutations and alterations have been reported in only four families with nonsyndromic ID and epilepsy. KIAA2022 is highly expressed in the fetal and adult brain and plays a crucial role in neuronal development. These additional patients support the evidence that KIAA2022 is a causative gene for XLID. © 2015 Wiley Periodicals, Inc.
91. ARAIII. GCRE reactor building (ARA608) at 48 percent completion. ...
91. ARA-III. GCRE reactor building (ARA-608) at 48 percent completion. Camera faces west end of building; shows roll-up door. High bay section on right view. Petro-chem heater stack extends above roof of low-bay section on left. Excavation for 13, 8 kv electrical conduit in foreground. January 20, 1959. Ineel photo no. 59-322. Photographer: Jack L. Anderson. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID
Satyanarayana, Ande; Klarmann, Kimberly D.; Gavrilova, Oksana; Keller, Jonathan R.
2012-01-01
Obesity is a major health concern that contributes to the development of diabetes, hyperlipidemia, coronary artery disease, and cancer. Id proteins are helix-loop-helix transcription factors that regulate the proliferation and differentiation of cells from multiple tissues, including adipocytes. We screened mouse tissues for the expression of Id1 and found that Id1 protein is highly expressed in brown adipose tissue (BAT) and white adipose tissue (WAT), suggesting a role for Id1 in adipogenesis and cell metabolism. Id1−/− mice are viable but show a significant reduction in fat mass (P<0.005) over the life of the animal that was not due to decreased number of adipocytes. Analysis of Id1−/− mice revealed higher energy expenditure, increased lipolysis, and fatty acid oxidation, resulting in reduced triglyceride accumulation in WAT compared to Id1+/+ mice. Serum levels of triglycerides (193.9±32.2 vs. 86.5±33.8, P<0.0005), cholesterol (189.4±33.8 vs. 110.6±8.23, P<0.0005) and leptin (1263±835 vs. 222±260, P<0.005) were significantly lower in aged Id1−/− mice compared to Id1+/+ mice. Id1-deficient mice have higher resting (P<0.005) and total (P<0.05) O2 consumption and lower respiratory exchange ratio (P<0.005), confirming that Id1−/− mice use a higher proportion of lipid as an energy source for the increased energy expenditure. The expression of PGC1α and UCP1 were 2- to 3-fold up-regulated in Id1−/− BAT, suggesting that loss of Id1 increases thermogenesis. As a consequence of higher energy expenditure and reduced fat mass, Id1−/− mice displayed enhanced insulin sensitivity. Id1 deficiency protected mice against age- and high-fat-diet-induced adiposity, insulin resistance, and hepatosteatosis. Our findings suggest that Id1 plays a critical role in the regulation of energy homeostasis and could be a potential target in the treatment of insulin resistance and fatty liver disease.—Satyanarayana, A., Klarmann, K. D., Gavrilova, l O., Keller, J. R. Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet-induced insulin resistance and hepatosteatosis. PMID:21990377
Sharma, Pankaj; Gupta, Neerja; Chowdhury, Madhumita Roy; Sapra, Savita; Ghosh, Manju; Gulati, Sheffali; Kabra, Madhulika
2016-09-15
Intellectual disability (ID)/Global developmental delay (GDD) is a diverse group of disorders in terms of cognitive and non-cognitive functions and can occur with or without associated co-morbidities. It affects 1-3% of individuals globally and in at least 30-50% of cases the etiology remains unexplained. The widespread use of chromosomal microarray analysis (CMA) in a clinical setting has allowed the identification of submicroscopic copy number variations (CNVs), throughout the genome, associated with neurodevelopmental phenotypes including ID/GDD. In this study we investigated the utility of CMA in the detection of CNVs in 106 patients with unexplained ID/DD, dysmorphism with or without multiple congenital anomalies (MCA). CMA study was carried out using Agilent 8×60K chips and Illumina Human CytoSNP-12 chips. Pathogenic CNVs were found in 15 (14.2%) patients. In these patients, CNVs on single chromosome were detected in 10 patients while 5 patients showed co-occurrence CNVs on two chromosomes. The size of these CNVs ranged between 322kb to 13Mb. The yield of pathogenic CNVs was similar for both mild and severe ID/GDD cases. One patient described in this paper is considered to harbour a likely pathogenic CNV with deletion in 17q22 region. Only few cases have been described in literature for 17q22 deletion and patient reported here was found to have an atypical deletion in 17q22 region (Case 90). This study re-affirms the view point that CMA is a powerful diagnostic tool in the evaluation of idiopathic ID/GDD patients irrespective of the degree of severity. Identifying pathogenic CNVs helps in counseling and prenatal diagnosis if desired. Copyright © 2016 Elsevier B.V. All rights reserved.
On complexity of trellis structure of linear block codes
NASA Technical Reports Server (NTRS)
Lin, Shu
1990-01-01
The trellis structure of linear block codes (LBCs) is discussed. The state and branch complexities of a trellis diagram (TD) for a LBC is investigated. The TD with the minimum number of states is said to be minimal. The branch complexity of a minimal TD for a LBC is expressed in terms of the dimensions of specific subcodes of the given code. Then upper and lower bounds are derived on the number of states of a minimal TD for a LBC, and it is shown that a cyclic (or shortened cyclic) code is the worst in terms of the state complexity among the LBCs of the same length and dimension. Furthermore, it is shown that the structural complexity of a minimal TD for a LBC depends on the order of its bit positions. This fact suggests that an appropriate permutation of the bit positions of a code may result in an equivalent code with a much simpler minimal TD. Boolean polynomial representation of codewords of a LBC is also considered. This representation helps in study of the trellis structure of the code. Boolean polynomial representation of a code is applied to construct its minimal TD. Particularly, the construction of minimal trellises for Reed-Muller codes and the extended and permuted binary primitive BCH codes which contain Reed-Muller as subcodes is emphasized. Finally, the structural complexity of minimal trellises for the extended and permuted, and double-error-correcting BCH codes is analyzed and presented. It is shown that these codes have relatively simple trellis structure and hence can be decoded with the Viterbi decoding algorithm.
Press Pelease Image - STS-1 - Earth View
1981-04-12
S81-30396 (12-14 April 1981) --- A vertical view of Eleuthera Island in the Bahamas and part of the great Bahama Bank, as photographed with a 70mm handheld camera from the space shuttle Columbia in Earth orbit. The light blue of the Bahama Bank contrasts sharply with the darker blue of the deep ocean waters. Astronauts John W. Young, commander, and Robert L. Crippen, pilot, took a series of Earth photos from inside the flight deck of the Columbia, which has windows on its top side, convenient for shooting photographs as the spacecraft flew ?upside down? above Earth. The mission frame ID number is STS001-12-322. Photo credit: NASA
Brett, Maggie; McPherson, John; Zang, Zhi Jiang; Lai, Angeline; Tan, Ee-Shien; Ng, Ivy; Ong, Lai-Choo; Cham, Breana; Tan, Patrick; Rozen, Steve; Tan, Ene-Choo
2014-01-01
Developmental delay and/or intellectual disability (DD/ID) affects 1–3% of all children. At least half of these are thought to have a genetic etiology. Recent studies have shown that massively parallel sequencing (MPS) using a targeted gene panel is particularly suited for diagnostic testing for genetically heterogeneous conditions. We report on our experiences with using massively parallel sequencing of a targeted gene panel of 355 genes for investigating the genetic etiology of eight patients with a wide range of phenotypes including DD/ID, congenital anomalies and/or autism spectrum disorder. Targeted sequence enrichment was performed using the Agilent SureSelect Target Enrichment Kit and sequenced on the Illumina HiSeq2000 using paired-end reads. For all eight patients, 81–84% of the targeted regions achieved read depths of at least 20×, with average read depths overlapping targets ranging from 322× to 798×. Causative variants were successfully identified in two of the eight patients: a nonsense mutation in the ATRX gene and a canonical splice site mutation in the L1CAM gene. In a third patient, a canonical splice site variant in the USP9X gene could likely explain all or some of her clinical phenotypes. These results confirm the value of targeted MPS for investigating DD/ID in children for diagnostic purposes. However, targeted gene MPS was less likely to provide a genetic diagnosis for children whose phenotype includes autism. PMID:24690944
Mägi, Agnes; Unt, Eve; Prans, Ele; Raus, Liina; Eha, Jaan; Veraksitš, Alar; Kingo, Külli; Kõks, Sulev
2016-06-01
Endurance performance depends on the integration of several phenotypic traits influenced by multiple environmental and genetic factors. Objectives of the study were: (1) to examine the genotypic frequencies of the ACE I/D, ACTN3 R577X polymorphisms and endurance performance-related phenotypes, (2) to evaluate the dynamics of endurance performance parameters during a 5-year period in relation to ACE I/D and ACTN3 R577X genotypes in Estonian young skiers. Determination of VO2peak was performed in 58 skiers aged 15-19 years (41 males, 17 females) during a 5-year period. The control group consisted of 322 healthy non-athletic subjects (145 males, 177 females). The study groups were genotyped for the ACE I/D and ACTN3 R577X variants. Frequencies of the ACE ID and ACTN3 RR genotypes were significantly higher (p = 0.047 and p = 0.003, respectively) and the RX genotype was lower (p = 0.008) in young male skiers compared with controls. A significant relationship was found between change (Δ) of training volume and ΔVO2peak (mL·kg(-1)·min(-1)) (r = 0.475, p = 0.002). No significant main effect was detected between VO2peak (mL·kg(-1)·min(-1)) dynamics (comparison with the previous age group data) and ACE I/D and ACTN3 R577X genotypes interactions (F = 0.571, p = 0.770 and F = 0.650 and p = 0.705, respectively) in all young skiers. Study results indicated a significantly higher frequency of the ACE ID and ACTN3 RR genotypes among Estonian young male skiers compared with the male control group. Significant genotype-related differences in dynamics of VO2peak during a 5-year period were not found. In the future, longitudinal research including different gene variants may contribute to a better understanding of the nature of endurance performance. Key pointsSignificantly higher prevalence of the ACE ID and the ACTN3 RR genotypes were found among Estonian young male skiers compared with the male control group, which may be an advantage for the explosive speed and power capacity in race skiing.A more remarkable trend of increase in VO2peak (mL·kg(-1)·min(-1)) during the 5-year period was observed among male skiers with the ACTN3 XX genotype and among female skiers with the ACE ID genotype.No significant genotype-related associations in the dynamics of VO2peak were found during the 5-year period.
Mägi, Agnes; Unt, Eve; Prans, Ele; Raus, Liina; Eha, Jaan; Veraksitš, Alar; Kingo, Külli; Kõks, Sulev
2016-01-01
Endurance performance depends on the integration of several phenotypic traits influenced by multiple environmental and genetic factors. Objectives of the study were: (1) to examine the genotypic frequencies of the ACE I/D, ACTN3 R577X polymorphisms and endurance performance-related phenotypes, (2) to evaluate the dynamics of endurance performance parameters during a 5-year period in relation to ACE I/D and ACTN3 R577X genotypes in Estonian young skiers. Determination of VO2peak was performed in 58 skiers aged 15-19 years (41 males, 17 females) during a 5-year period. The control group consisted of 322 healthy non-athletic subjects (145 males, 177 females). The study groups were genotyped for the ACE I/D and ACTN3 R577X variants. Frequencies of the ACE ID and ACTN3 RR genotypes were significantly higher (p = 0.047 and p = 0.003, respectively) and the RX genotype was lower (p = 0.008) in young male skiers compared with controls. A significant relationship was found between change (Δ) of training volume and ΔVO2peak (mL·kg-1·min-1) (r = 0.475, p = 0.002). No significant main effect was detected between VO2peak (mL·kg-1·min-1) dynamics (comparison with the previous age group data) and ACE I/D and ACTN3 R577X genotypes interactions (F = 0.571, p = 0.770 and F = 0.650 and p = 0.705, respectively) in all young skiers. Study results indicated a significantly higher frequency of the ACE ID and ACTN3 RR genotypes among Estonian young male skiers compared with the male control group. Significant genotype-related differences in dynamics of VO2peak during a 5-year period were not found. In the future, longitudinal research including different gene variants may contribute to a better understanding of the nature of endurance performance. Key points Significantly higher prevalence of the ACE ID and the ACTN3 RR genotypes were found among Estonian young male skiers compared with the male control group, which may be an advantage for the explosive speed and power capacity in race skiing. A more remarkable trend of increase in VO2peak (mL·kg-1·min-1) during the 5-year period was observed among male skiers with the ACTN3 XX genotype and among female skiers with the ACE ID genotype. No significant genotype-related associations in the dynamics of VO2peak were found during the 5-year period. PMID:27274666
Amirfakhrian, Hossein; Abedi, Seyed Mohammad; Sadeghi, Hossein; Azizi, Soheil; Hosseinimehr, Seyed Jalal
2018-01-01
In this study, we investigated the protective effect of vitamin E against methotrexate (MTX)-induced hepatotoxicity by quantitative liver 99mTc-phytate uptake and liver imaging and to compare its effect with histopathology in rat. Rats were divided into five groups as control, solvent, Vit E (100 mg/kg), MTX (20 mg/kg), Vit E + MTX and. Vit E was intraperitoneally administrated for 17 days before MTX injection and continued for 4 days. 99mTc-phytate was injected through the tail of rats after the drug administration. The percentage of the injected dose per gram of liver and spleen tissues (%ID/g) was calculated. Liver imaging was obtained with gamma camera. In other experiment, liver of treated rats were assessed for histopathology. 99mTc-phytate uptake per gram tissue of the livers as %ID/g in control, solvent, MTX, Vit E, Vit E + MTX and MTX groups were 8.99% ± 1.37, 8.53% ± 2.91, 8.65% ± 3.84, 3.22% ± 1.09 and 8.38% ± 2.68. Vit E administration with MTX resulted in a significant increasing in the level of %ID/g. Vit E treatment improved the shape of live in planner image. Histophatological examinations showed a protective effect of Vit E against MTX-induced hepatoxicity in rats. The results showed that Vit E significantly attenuates the MTX-induced hepatotoxicity in rats, and 99mTc-phytate uptake in liver as well as liver image to be acceptable techniques for assessment of liver and spleen damages and/or their tissues protective effects in animal model.
Fuel thermal conductivity (FTHCON). Status report. [PWR; BWR
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hagrman, D. L.
1979-02-01
An improvement of the fuel thermal conductivity subcode is described which is part of the fuel rod behavior modeling task performed at EG and G Idaho, Inc. The original version was published in the Materials Properties (MATPRO) Handbook, Section A-2 (Fuel Thermal Conductivity). The improved version incorporates data which were not included in the previous work and omits some previously used data which are believed to come from cracked specimens. The models for the effect of porosity on thermal conductivity and for the electronic contribution to thermal coductivity have been completely revised in order to place these models on amore » more mechanistic basis. As a result of modeling improvements the standard error of the model with respect to its data base has been significantly reduced.« less
Enantioselective Tissue Distribution of Ketorolac and its Enantiomers in Rats.
Dubey, S K; Anand, A; Saha, R N
2015-08-01
The difference in tissue distribution of Ketorolac and its enantiomers were investigated in wistar rats. Separate high performance liquid chromatographic method was developed and validated for determination of Ketorolac and its enantiomers. Oyster BDS (150 × 4.6 mm id., 5 μm particle size) column was used for determination of concentration of Ketorolac. Ketorolac enantiomers were determined using Chiral-AGP column (100 × 4.0 mm I.D., particle size 5 μ, Chrom tech Ltd, Sweden). Detection was done at wavelength of 322 nm using an ultraviolet detector in the analytical system. Ketorolac enantiomers exhibit difference in their disposition in Wistar rats. In kidney, there was a significant difference in pharmacokinetic parameters. The Cmax was nearly 4 times and AUC 0-∞ was found to be more than double for S (-) Ketorolac than that of R (+) Ketorolac. MRT, Ke and t1/2 differ significantly in kidney. In liver, Cmax was found to be approximately 69% higher for S (-) Ketorolac compared to R (+) Ketorolac. AUC 0-∞ did not differ significantly for the enantiomers in liver. In liver, S (-) Ketorolac eliminated very fast in comparison to R (+) Ketorolac having t1/2 (one third) in comparison to R (+) Ketorolac. In lungs, there was no difference observed for Cmax and other parameters but AUC 0-∞ was found to be marginally higher for S (-) ketorolac. © Georg Thieme Verlag KG Stuttgart · New York.
Optical and Event-Duration Variables Affecting Self-Motion Perception.
1985-11-01
0000 SZKO 6 .511 .16 2.22 .0467 GK 2 .463 .14 6.19 .0029 ZFK 4 .468 .14 2.66 .0336 Total 5939 328.401 100.00 - - Note. Each effect was tested using...0 . 322 1.322 2.322 3.322 4.322 5.322 LOG 2 PREVIEW PERIOD (s) (0) (1.25) (2.50) (5.0) (10.0) (20.0) (40.0) PREVIEW PERIOD (s) Figure 19. Percent...DECELERATING 6-.- - z 0 w1) 3 0 z F0 I, I I I 1 I 0 . 322 1 . 322 2.322 3.322 4.: 322 5.322 LOG2 PREVIEW PERIOD (s) ~(0) (1.25) (2.50) (5.0) (10.0) (20.0) (40.0
Park, Steven I.; Shenoi, Jaideep; Frayo, Shani M.; Hamlin, Donald K.; Lin, Yukang; Wilbur, D. Scott; Stayton, Patrick S.; Orgun, Nural; Hylarides, Mark; Buchegger, Franz; Kenoyer, Aimee L.; Axtman, Amanda; Gopal, Ajay K.; Green, Damian J.; Pagel, John M.; Press, Oliver W.
2011-01-01
Purpose Pretargeted radioimmunotherapy (PRIT) using streptavidin (SAv)-biotin technology can deliver higher therapeutic doses of radioactivity to tumors than conventional RIT. However, “endogenous” biotin can interfere with the effectiveness of this approach by blocking binding of radiolabeled biotin to SAv. We engineered a series of SAv FPs that down-modulate the affinity of SAv for biotin, while retaining high avidity for divalent DOTA-bis-biotin to circumvent this problem. Experimental Design The single-chain variable region gene of the murine 1F5 anti-CD20 antibody was fused to the wild-type (WT) SAv gene and to mutant SAv genes, Y43A-SAv and S45A-SAv. FPs were expressed, purified and compared in studies using athymic mice bearing Ramos lymphoma xenografts. Results Biodistribution studies demonstrated delivery of more radioactivity to tumors of mice pretargeted with mutant SAv FPs followed by 111In-DOTA-bis-biotin (6.2 ± 1.7 % of the injected dose per gram [%ID/gm] of tumor 24 hours after Y43A-SAv FP and 5.6 ± 2.2 %ID/g with S45A-SAv FP) than in mice on normal diets pretargeted with WT-SAv FP (2.5 ± 1.6 %ID/g; p = 0.01). These superior biodistributions translated into superior anti-tumor efficacy in mice treated with mutant FPs and 90Y-DOTA-bis-biotin (tumor volumes after 11 days: 237 ± 66 mm3 with Y43A-SAv, 543 ± 320 mm3 with S45A-SAv, 1129 ± 322 mm3 with WT-SAv and 1435 ± 212 mm3 with control FP [p < 0.0001]). Conclusions Genetically engineered mutant-SAv FPs and bis-biotin reagents provide an attractive alternative to current SAv-biotin PRIT methods in settings where endogenous biotin levels are high. PMID:21976541
Park, Steven I; Shenoi, Jaideep; Frayo, Shani M; Hamlin, Donald K; Lin, Yukang; Wilbur, D Scott; Stayton, Patrick S; Orgun, Nural; Hylarides, Mark; Buchegger, Franz; Kenoyer, Aimee L; Axtman, Amanda; Gopal, Ajay K; Green, Damian J; Pagel, John M; Press, Oliver W
2011-12-01
Pretargeted radioimmunotherapy (PRIT) using streptavidin (SAv)-biotin technology can deliver higher therapeutic doses of radioactivity to tumors than conventional RIT. However, "endogenous" biotin can interfere with the effectiveness of this approach by blocking binding of radiolabeled biotin to SAv. We engineered a series of SAv FPs that downmodulate the affinity of SAv for biotin, while retaining high avidity for divalent DOTA-bis-biotin to circumvent this problem. The single-chain variable region gene of the murine 1F5 anti-CD20 antibody was fused to the wild-type (WT) SAv gene and to mutant SAv genes, Y43A-SAv and S45A-SAv. FPs were expressed, purified, and compared in studies using athymic mice bearing Ramos lymphoma xenografts. Biodistribution studies showed delivery of more radioactivity to tumors of mice pretargeted with mutant SAv FPs followed by (111)In-DOTA-bis-biotin [6.2 ± 1.7% of the injected dose per gram (%ID/gm) of tumor 24 hours after Y43A-SAv FP and 5.6 ± 2.2%ID/g with S45A-SAv FP] than in mice on normal diets pretargeted with WT-SAv FP (2.5 ± 1.6%ID/g; P = 0.01). These superior biodistributions translated into superior antitumor efficacy in mice treated with mutant FPs and (90)Y-DOTA-bis-biotin [tumor volumes after 11 days: 237 ± 66 mm(3) with Y43A-SAv, 543 ± 320 mm(3) with S45A-SAv, 1129 ± 322 mm(3) with WT-SAv, and 1435 ± 212 mm(3) with control FP (P < 0.0001)]. Genetically engineered mutant-SAv FPs and bis-biotin reagents provide an attractive alternative to current SAv-biotin PRIT methods in settings where endogenous biotin levels are high. ©2011 AACR.
The weight hierarchies and chain condition of a class of codes from varieties over finite fields
NASA Technical Reports Server (NTRS)
Wu, Xinen; Feng, Gui-Liang; Rao, T. R. N.
1996-01-01
The generalized Hamming weights of linear codes were first introduced by Wei. These are fundamental parameters related to the minimal overlap structures of the subcodes and very useful in several fields. It was found that the chain condition of a linear code is convenient in studying the generalized Hamming weights of the product codes. In this paper we consider a class of codes defined over some varieties in projective spaces over finite fields, whose generalized Hamming weights can be determined by studying the orbits of subspaces of the projective spaces under the actions of classical groups over finite fields, i.e., the symplectic groups, the unitary groups and orthogonal groups. We give the weight hierarchies and generalized weight spectra of the codes from Hermitian varieties and prove that the codes satisfy the chain condition.
Constructions for finite-state codes
NASA Technical Reports Server (NTRS)
Pollara, F.; Mceliece, R. J.; Abdel-Ghaffar, K.
1987-01-01
A class of codes called finite-state (FS) codes is defined and investigated. These codes, which generalize both block and convolutional codes, are defined by their encoders, which are finite-state machines with parallel inputs and outputs. A family of upper bounds on the free distance of a given FS code is derived from known upper bounds on the minimum distance of block codes. A general construction for FS codes is then given, based on the idea of partitioning a given linear block into cosets of one of its subcodes, and it is shown that in many cases the FS codes constructed in this way have a d sub free which is as large as possible. These codes are found without the need for lengthy computer searches, and have potential applications for future deep-space coding systems. The issue of catastropic error propagation (CEP) for FS codes is also investigated.
20 CFR 322.4 - Consideration of evidence.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification...
20 CFR 322.4 - Consideration of evidence.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification...
20 CFR 322.4 - Consideration of evidence.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification...
49 CFR 172.322 - Marine pollutants.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 49 Transportation 2 2012-10-01 2012-10-01 false Marine pollutants. 172.322 Section 172.322... SECURITY PLANS Marking § 172.322 Marine pollutants. (a) For vessel transportation of each non-bulk packaging that contains a marine pollutant— (1) If the proper shipping name for a material which is a marine...
49 CFR 172.322 - Marine pollutants.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 49 Transportation 2 2014-10-01 2014-10-01 false Marine pollutants. 172.322 Section 172.322... SECURITY PLANS Marking § 172.322 Marine pollutants. (a) For vessel transportation of each non-bulk packaging that contains a marine pollutant— (1) If the proper shipping name for a material which is a marine...
20 CFR 322.4 - Consideration of evidence.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification that he or she...
20 CFR 322.4 - Consideration of evidence.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification that he or she...
32 CFR 322.4 - Responsibilities.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 32 National Defense 2 2014-07-01 2014-07-01 false Responsibilities. 322.4 Section 322.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.4 Responsibilities. (a) The...
32 CFR 322.4 - Responsibilities.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 32 National Defense 2 2012-07-01 2012-07-01 false Responsibilities. 322.4 Section 322.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.4 Responsibilities. (a) The...
32 CFR 322.4 - Responsibilities.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 32 National Defense 2 2013-07-01 2013-07-01 false Responsibilities. 322.4 Section 322.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.4 Responsibilities. (a) The...
20 CFR 322.5 - Payments under vacation agreements.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Payments under vacation agreements. 322.5 Section 322.5 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.5 Payments under vacation agreements. (a) General. In ascertaining the...
20 CFR 322.8 - Miscellaneous income.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Miscellaneous income. 322.8 Section 322.8 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.8 Miscellaneous income. (a) Income from self-employment. In determining whether income from...
20 CFR 322.8 - Miscellaneous income.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Miscellaneous income. 322.8 Section 322.8 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.8 Miscellaneous income. (a) Income from self-employment. In determining whether income from...
20 CFR 322.5 - Payments under vacation agreements.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Payments under vacation agreements. 322.5 Section 322.5 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.5 Payments under vacation agreements. (a) General. In ascertaining the...
20 CFR 322.8 - Miscellaneous income.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Miscellaneous income. 322.8 Section 322.8 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.8 Miscellaneous income. (a) Income from self-employment. In determining whether income from...
20 CFR 322.5 - Payments under vacation agreements.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Payments under vacation agreements. 322.5 Section 322.5 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.5 Payments under vacation agreements. (a) General. In ascertaining the...
20 CFR 322.5 - Payments under vacation agreements.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Payments under vacation agreements. 322.5 Section 322.5 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.5 Payments under vacation agreements. (a) General. In ascertaining the...
20 CFR 322.8 - Miscellaneous income.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Miscellaneous income. 322.8 Section 322.8 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.8 Miscellaneous income. (a) Income from self-employment. In determining whether income from...
20 CFR 322.5 - Payments under vacation agreements.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Payments under vacation agreements. 322.5 Section 322.5 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.5 Payments under vacation agreements. (a) General. In ascertaining the...
20 CFR 322.8 - Miscellaneous income.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Miscellaneous income. 322.8 Section 322.8 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.8 Miscellaneous income. (a) Income from self-employment. In determining whether income from...
28 CFR 32.2 - Computation of time; filing.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Computation of time; filing. 32.2 Section 32.2 Judicial Administration DEPARTMENT OF JUSTICE PUBLIC SAFETY OFFICERS' DEATH, DISABILITY, AND EDUCATIONAL ASSISTANCE BENEFIT CLAIMS General Provisions § 32.2 Computation of time; filing. (a) In computing...
33 CFR 183.322 - Flotation materials.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Flotation materials. 183.322 Section 183.322 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... of 2 Horsepower or Less General § 183.322 Flotation materials. (a) Flotation materials must meet the...
Code of Federal Regulations, 2012 CFR
2012-07-01
... 32 National Defense 2 2012-07-01 2012-07-01 false Policy. 322.3 Section 322.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.3 Policy. (a) The National Security...
Code of Federal Regulations, 2011 CFR
2011-07-01
... 32 National Defense 2 2011-07-01 2011-07-01 false Policy. 322.3 Section 322.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.3 Policy. (a) The National Security...
Code of Federal Regulations, 2014 CFR
2014-07-01
... 32 National Defense 2 2014-07-01 2014-07-01 false Policy. 322.3 Section 322.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.3 Policy. (a) The National Security...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 322.3 Section 322.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.3 Policy. (a) The National Security...
Code of Federal Regulations, 2013 CFR
2013-07-01
... 32 National Defense 2 2013-07-01 2013-07-01 false Policy. 322.3 Section 322.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.3 Policy. (a) The National Security...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 1 2013-01-01 2013-01-01 false Discovery. 1.322 Section 1.322 Agriculture Office of... Under the Program Fraud Civil Remedies Act of 1986 § 1.322 Discovery. (a) The following types of discovery are authorized: (1) Requests for production, inspection and photocopying of documents; (2...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 1 2014-01-01 2014-01-01 false Discovery. 1.322 Section 1.322 Agriculture Office of... Under the Program Fraud Civil Remedies Act of 1986 § 1.322 Discovery. (a) The following types of discovery are authorized: (1) Requests for production, inspection and photocopying of documents; (2...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 1 2011-01-01 2011-01-01 false Discovery. 1.322 Section 1.322 Agriculture Office of... Under the Program Fraud Civil Remedies Act of 1986 § 1.322 Discovery. (a) The following types of discovery are authorized: (1) Requests for production, inspection and photocopying of documents; (2...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 1 2012-01-01 2012-01-01 false Discovery. 1.322 Section 1.322 Agriculture Office of... Under the Program Fraud Civil Remedies Act of 1986 § 1.322 Discovery. (a) The following types of discovery are authorized: (1) Requests for production, inspection and photocopying of documents; (2...
33 CFR 183.322 - Flotation materials.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Flotation materials. 183.322 Section 183.322 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... of 2 Horsepower or Less General § 183.322 Flotation materials. (a) Flotation materials must meet the...
33 CFR 183.322 - Flotation materials.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Flotation materials. 183.322 Section 183.322 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... of 2 Horsepower or Less General § 183.322 Flotation materials. (a) Flotation materials must meet the...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 1 2010-01-01 2010-01-01 false Discovery. 1.322 Section 1.322 Agriculture Office of... Under the Program Fraud Civil Remedies Act of 1986 § 1.322 Discovery. (a) The following types of discovery are authorized: (1) Requests for production, inspection and photocopying of documents; (2...
28 CFR 32.2 - Computation of time; filing.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Computation of time; filing. 32.2 Section 32.2 Judicial Administration DEPARTMENT OF JUSTICE PUBLIC SAFETY OFFICERS' DEATH, DISABILITY, AND EDUCATIONAL ASSISTANCE BENEFIT CLAIMS General Provisions § 32.2 Computation of time; filing. (a) In computing...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false Dead bees. 322.29 Section 322.29 Agriculture..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of Restricted Articles § 322.29 Dead bees. (a) Dead bees imported into or transiting the United States must be...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false Dead bees. 322.29 Section 322.29 Agriculture..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of Restricted Articles § 322.29 Dead bees. (a) Dead bees imported into or transiting the United States must be...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Dead bees. 322.29 Section 322.29 Agriculture..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of Restricted Articles § 322.29 Dead bees. (a) Dead bees imported into or transiting the United States must be...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false Dead bees. 322.29 Section 322.29 Agriculture..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of Restricted Articles § 322.29 Dead bees. (a) Dead bees imported into or transiting the United States must be...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false Dead bees. 322.29 Section 322.29 Agriculture..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of Restricted Articles § 322.29 Dead bees. (a) Dead bees imported into or transiting the United States must be...
43 CFR 4.322 - What must an appeal contain?
Code of Federal Regulations, 2011 CFR
2011-10-01
... Probate Matters § 4.322 What must an appeal contain? (a) Each appeal must contain a written statement of... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false What must an appeal contain? 4.322 Section 4.322 Public Lands: Interior Office of the Secretary of the Interior DEPARTMENT HEARINGS AND APPEALS...
Code of Federal Regulations, 2013 CFR
2013-10-01
... access hospitals, and tissue banks. 486.322 Section 486.322 Public Health CENTERS FOR MEDICARE & MEDICAID... Measures § 486.322 Condition: Relationships with hospitals, critical access hospitals, and tissue banks. (a... hospital and critical access hospital staff. (c) Standard: Cooperation with tissue banks. (1) The OPO must...
Code of Federal Regulations, 2014 CFR
2014-10-01
... access hospitals, and tissue banks. 486.322 Section 486.322 Public Health CENTERS FOR MEDICARE & MEDICAID... Measures § 486.322 Condition: Relationships with hospitals, critical access hospitals, and tissue banks. (a... hospital and critical access hospital staff. (c) Standard: Cooperation with tissue banks. (1) The OPO must...
Code of Federal Regulations, 2010 CFR
2010-10-01
... access hospitals, and tissue banks. 486.322 Section 486.322 Public Health CENTERS FOR MEDICARE & MEDICAID... Measures § 486.322 Condition: Relationships with hospitals, critical access hospitals, and tissue banks. (a... hospital and critical access hospital staff. (c) Standard: Cooperation with tissue banks. (1) The OPO must...
Code of Federal Regulations, 2012 CFR
2012-10-01
... access hospitals, and tissue banks. 486.322 Section 486.322 Public Health CENTERS FOR MEDICARE & MEDICAID... Measures § 486.322 Condition: Relationships with hospitals, critical access hospitals, and tissue banks. (a... hospital and critical access hospital staff. (c) Standard: Cooperation with tissue banks. (1) The OPO must...
Code of Federal Regulations, 2011 CFR
2011-10-01
... access hospitals, and tissue banks. 486.322 Section 486.322 Public Health CENTERS FOR MEDICARE & MEDICAID... Measures § 486.322 Condition: Relationships with hospitals, critical access hospitals, and tissue banks. (a... hospital and critical access hospital staff. (c) Standard: Cooperation with tissue banks. (1) The OPO must...
31 CFR 561.322 - Entity owned or controlled by the Government of Iran.
Code of Federal Regulations, 2014 CFR
2014-07-01
... Government of Iran. 561.322 Section 561.322 Money and Finance: Treasury Regulations Relating to Money and... SANCTIONS REGULATIONS General Definitions § 561.322 Entity owned or controlled by the Government of Iran. The phrase entity owned or controlled by the Government of Iran means any entity, including a...
31 CFR 561.322 - Entity owned or controlled by the Government of Iran.
Code of Federal Regulations, 2012 CFR
2012-07-01
... Government of Iran. 561.322 Section 561.322 Money and Finance: Treasury Regulations Relating to Money and... SANCTIONS REGULATIONS General Definitions § 561.322 Entity owned or controlled by the Government of Iran. The phrase entity owned or controlled by the Government of Iran means any entity, including a...
31 CFR 561.322 - Entity owned or controlled by the Government of Iran.
Code of Federal Regulations, 2013 CFR
2013-07-01
... Government of Iran. 561.322 Section 561.322 Money and Finance: Treasury Regulations Relating to Money and... SANCTIONS REGULATIONS General Definitions § 561.322 Entity owned or controlled by the Government of Iran. The phrase entity owned or controlled by the Government of Iran means any entity, including a...
20 CFR 322.6 - Pay for time lost.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Pay for time lost. 322.6 Section 322.6 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.6 Pay for time lost. (a) Definition. The term “pay for time lost” means any payment made to...
20 CFR 322.6 - Pay for time lost.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Pay for time lost. 322.6 Section 322.6 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.6 Pay for time lost. (a) Definition. The term “pay for time lost” means any payment made to...
20 CFR 322.6 - Pay for time lost.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Pay for time lost. 322.6 Section 322.6 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.6 Pay for time lost. (a) Definition. The term “pay for time lost” means any payment made to...
20 CFR 322.6 - Pay for time lost.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Pay for time lost. 322.6 Section 322.6 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.6 Pay for time lost. (a) Definition. The term “pay for time lost” means any payment made to...
20 CFR 322.6 - Pay for time lost.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Pay for time lost. 322.6 Section 322.6 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.6 Pay for time lost. (a) Definition. The term “pay for time lost” means any payment made to...
40 CFR 300.322 - Response to substantial threats to public health or welfare of the United States.
Code of Federal Regulations, 2013 CFR
2013-07-01
... public health or welfare of the United States. 300.322 Section 300.322 Protection of Environment... Removal § 300.322 Response to substantial threats to public health or welfare of the United States. (a) As... in a substantial threat to public health or welfare of the United States (including, but not limited...
40 CFR 300.322 - Response to substantial threats to public health or welfare of the United States.
Code of Federal Regulations, 2012 CFR
2012-07-01
... public health or welfare of the United States. 300.322 Section 300.322 Protection of Environment... Removal § 300.322 Response to substantial threats to public health or welfare of the United States. (a) As... in a substantial threat to public health or welfare of the United States (including, but not limited...
40 CFR 300.322 - Response to substantial threats to public health or welfare of the United States.
Code of Federal Regulations, 2014 CFR
2014-07-01
... public health or welfare of the United States. 300.322 Section 300.322 Protection of Environment... Removal § 300.322 Response to substantial threats to public health or welfare of the United States. (a) As... in a substantial threat to public health or welfare of the United States (including, but not limited...
40 CFR 300.322 - Response to substantial threats to public health or welfare of the United States.
Code of Federal Regulations, 2010 CFR
2010-07-01
... public health or welfare of the United States. 300.322 Section 300.322 Protection of Environment... Removal § 300.322 Response to substantial threats to public health or welfare of the United States. (a) As... in a substantial threat to public health or welfare of the United States (including, but not limited...
40 CFR 300.322 - Response to substantial threats to public health or welfare of the United States.
Code of Federal Regulations, 2011 CFR
2011-07-01
... public health or welfare of the United States. 300.322 Section 300.322 Protection of Environment... Removal § 300.322 Response to substantial threats to public health or welfare of the United States. (a) As... in a substantial threat to public health or welfare of the United States (including, but not limited...
Montgomery, M D; Bylund, D B
2010-02-01
The alpha(2C)-adrenoceptor has multiple functions, including inhibiting release of noradrenaline from presynaptic nerve terminals. A human alpha(2C) polymorphism, Del322-325, a potential risk factor for heart failure, has been reported to exhibit reduced signalling in CHO cells. To further understand the role of the Del322-325 polymorphism on receptor signalling, we attempted to replicate and further study the reduced signalling in HEK293 cells. Human alpha(2C) wild-type (WT) and Del322-325 adrenoceptors were stably transfected into HEK293 cells. Radioligand binding was performed to determine affinities for both receptors. In intact cells, inhibition of forskolin-stimulated cyclic AMP production by WT and Del322-325 clones with a range of receptor densities (200-2320 fmol.mg(-1) protein) was measured following agonist treatment. Noradrenaline, brimonidine and clonidine exhibited similar binding affinities for WT and Del322-325. Brimonidine and clonidine also had similar efficacies and potencies for both receptors for the inhibition of cyclic AMP production at all receptor densities tested. A linear regression analysis comparing efficacy and potency with receptor expression levels showed no differences in slopes between WT and Del322-325. The alpha(2C) WT and Del322-325 adrenoceptors exhibited similar binding properties. Additionally, inhibition of cyclic AMP production by Del322-325 was similar to that of WT over a range of receptor densities. Therefore, in intact HEK293 cells, the alpha(2C)-Del322-325 polymorphism does not exhibit reduced signalling to adenylyl cyclase and may not represent a clinically important phenotype.
Zhao, Xiaoqin; Rong, Can; Pan, Fenghui; Xiang, Lizhi; Wang, Xinlei; Hu, Yun
2018-06-28
Increasing evidence indicates that long noncoding RNAs (lncRNAs) perform special biological functions by regulating gene expression through multiple pathways and molecular mechanisms. The aim of this study was to explore the expression characteristics of lncRNA uc.322 in pancreatic islet cells and its effects on the secretion function of islet cells. Bioinformatics analysis was used to detect the lncRNA uc.322 sequence, location, and structural features. Expression of lncRNA uc.322 in different tissues was detected by quantitative polymerase chain reaction analyses. Quantitative polymerase chain reaction, Western blot analysis, adenosine triphosphate determination, glucose-stimulated insulin secretion, and enzyme-linked immunosorbent assay were used to evaluate the effects of lncRNA uc.322 on insulin secretion. The results showed that the full-length of lncRNA uc.322 is 224 bp and that it is highly conserved in various species. Bioinformatics analysis revealed that lncRNA uc.322 is located on chr7:122893196-122893419 (GRCH37/hg19) within the SRY-related HMG-box 6 gene exon region. Compared with other tissues, lncRNA uc.322 is highly expressed in pancreatic tissue. Upregulation of lncRNA uc.322 expression increases the insulin transcription factors pancreatic and duodenal homeobox 1 and Forkhead box O1 expression, promotes insulin secretion in the extracellular fluid of Min6 cells, and increases the adenosine triphosphate concentration. On the other hand, knockdown of lncRNA uc.322 has opposite effects on Min6 cells. Overall, this study showed that upregulation of lncRNA uc.322 in islet β-cells can increase the expression of insulin transcription factors and promote insulin secretion, and it may be a new therapeutic target for diabetes. © 2018 Wiley Periodicals, Inc.
Code of Federal Regulations, 2010 CFR
2010-01-01
... Commission so orders. (c) Content. All written motions shall state the particular order, ruling, or action... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Motions. 3.22 Section 3.22 Commercial... ADJUDICATIVE PROCEEDINGS Prehearing Procedures; Motions; Interlocutory Appeals; Summary Decisions § 3.22...
Code of Federal Regulations, 2011 CFR
2011-01-01
... Commission so orders. (c) Content. All written motions shall state the particular order, ruling, or action... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Motions. 3.22 Section 3.22 Commercial... ADJUDICATIVE PROCEEDINGS Prehearing Procedures; Motions; Interlocutory Appeals; Summary Decisions § 3.22...
49 CFR 173.322 - Ethyl chloride.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 49 Transportation 2 2010-10-01 2010-10-01 false Ethyl chloride. 173.322 Section 173.322 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... SHIPMENTS AND PACKAGINGS Gases; Preparation and Packaging § 173.322 Ethyl chloride. Ethyl chloride must be...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-12
... Airworthiness Directives; Airbus Model A310-221, -222, -322, - 324, and -325 Airplanes, and Model A300 B4-620... applies to Airbus Model A310-221, -222, -322, -324, and -325 airplanes, and Model A300 B4-620, B4-622, B4... Model A310-221, - 222, -322, -324, and -325 airplanes), both including Appendix 1, both dated October 3...
47 CFR 27.322-27.325 - [Reserved
Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 2 2010-10-01 2010-10-01 false [Reserved] 27.322-27.325 Section 27.322-27.325 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Application, Licensing, and Processing Rules for WCS §§ 27.322-27.325 [Reserved] ...
47 CFR 27.322-27.325 - [Reserved
Code of Federal Regulations, 2011 CFR
2011-10-01
... 47 Telecommunication 2 2011-10-01 2011-10-01 false [Reserved] 27.322-27.325 Section 27.322-27.325 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Application, Licensing, and Processing Rules for WCS §§ 27.322-27.325 [Reserved] ...
7 CFR 1210.322 - Term of office.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 10 2010-01-01 2010-01-01 false Term of office. 1210.322 Section 1210.322 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... PLAN Watermelon Research and Promotion Plan National Watermelon Promotion Board § 1210.322 Term of...
Surface Electric Strength of Thermoplastic Materials in Vacuum
1981-11-27
For all the 1 lengths of investigated samples the flashover voltage showed the tendency of going down as the pressure increased from 133.322xi0" 6 Pa to...0,4 =326%10-8 133.32?*0 133= 322 -10V Figure 5.1. Flashover voltage as a function of pressure for samplesfrom polymethylmethacrylate. Direct...course of switching surge 400/2000 ýis L -76 AV L 1t0 01 1 01’O Tr W33.322.106 033.32210-" I33.322-10Ŗ 133.)2210- W3. 322 . 10-" Pa Figure 5.2
7 CFR 322.3 - Costs and charges.
Code of Federal Regulations, 2014 CFR
2014-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.3... accordance with § 322.2(c)(1). Further, if you import bees or germ plasm into a containment facility for...
7 CFR 322.3 - Costs and charges.
Code of Federal Regulations, 2013 CFR
2013-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.3... accordance with § 322.2(c)(1). Further, if you import bees or germ plasm into a containment facility for...
7 CFR 322.3 - Costs and charges.
Code of Federal Regulations, 2011 CFR
2011-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.3... accordance with § 322.2(c)(1). Further, if you import bees or germ plasm into a containment facility for...
7 CFR 322.3 - Costs and charges.
Code of Federal Regulations, 2010 CFR
2010-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.3... accordance with § 322.2(c)(1). Further, if you import bees or germ plasm into a containment facility for...
7 CFR 322.3 - Costs and charges.
Code of Federal Regulations, 2012 CFR
2012-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.3... accordance with § 322.2(c)(1). Further, if you import bees or germ plasm into a containment facility for...
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Extensions. 52.322 Section 52.322... PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.322 Extensions. The Administrator, by authority delegated..., 1995) the attainment date for the Denver, Colorado, PM-10 nonattainment area. [60 FR 52315, Oct. 6...
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Extensions. 52.322 Section 52.322... PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.322 Extensions. The Administrator, by authority delegated..., 1995) the attainment date for the Denver, Colorado, PM-10 nonattainment area. [60 FR 52315, Oct. 6...
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Extensions. 52.322 Section 52.322... PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.322 Extensions. The Administrator, by authority delegated..., 1995) the attainment date for the Denver, Colorado, PM-10 nonattainment area. [60 FR 52315, Oct. 6...
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Extensions. 52.322 Section 52.322... PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.322 Extensions. The Administrator, by authority delegated..., 1995) the attainment date for the Denver, Colorado, PM-10 nonattainment area. [60 FR 52315, Oct. 6...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Extensions. 52.322 Section 52.322... PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.322 Extensions. The Administrator, by authority delegated..., 1995) the attainment date for the Denver, Colorado, PM-10 nonattainment area. [60 FR 52315, Oct. 6...
31 CFR 29.322 - Disability benefits.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Disability benefits. 29.322 Section 29.322 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER CERTAIN DISTRICT OF COLUMBIA RETIREMENT PROGRAMS Split Benefits § 29.322 Disability benefits. If...
31 CFR 29.322 - Disability benefits.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Disability benefits. 29.322 Section 29.322 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER CERTAIN DISTRICT OF COLUMBIA RETIREMENT PROGRAMS Split Benefits § 29.322 Disability benefits. If...
48 CFR 322.810 - Solicitation provisions and contract clauses.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Solicitation provisions and contract clauses. 322.810 Section 322.810 Federal Acquisition Regulations System HEALTH AND HUMAN... Opportunity 322.810 Solicitation provisions and contract clauses. (h) The Contracting Officer shall insert the...
48 CFR 322.810 - Solicitation provisions and contract clauses.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Solicitation provisions and contract clauses. 322.810 Section 322.810 Federal Acquisition Regulations System HEALTH AND HUMAN... Opportunity 322.810 Solicitation provisions and contract clauses. (h) The Contracting Officer shall insert the...
78 FR 16245 - Submission for OMB Review; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-14
... making its determinations under Section 322(a) of the Act, and for providing relief under Section 322(b... Section 322(b) of the Act. Affected Public: Individuals or households; business or other for- profit...
20 CFR 633.322 - Sanctions for violation of the Act.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Sanctions for violation of the Act. 633.322 Section 633.322 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR MIGRANT AND SEASONAL FARMWORKER PROGRAMS Program Design and Administrative Procedures § 633.322 Sanctions for...
10 CFR 63.322 - Human intrusion scenario.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 2 2010-01-01 2010-01-01 false Human intrusion scenario. 63.322 Section 63.322 Energy... REPOSITORY AT YUCCA MOUNTAIN, NEVADA Postclosure Public Health and Environmental Standards Human Intrusion Standard § 63.322 Human intrusion scenario. For the purposes of the analysis of human intrusion, DOE must...
7 CFR 322.30 - Export certificate.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Export certificate. 322.30 Section 322.30 Agriculture... Restricted Articles § 322.30 Export certificate. Each shipment of restricted articles, except for dead bees, imported into or transiting the United States must be accompanied by an export certificate issued by the...
7 CFR 322.6 - Export certificate.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Export certificate. 322.6 Section 322.6 Agriculture... Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.6 Export... region must be accompanied by an export certificate issued by the appropriate regulatory agency of the...
32 CFR 322.7 - Exempt systems of records.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 32 National Defense 2 2013-07-01 2013-07-01 false Exempt systems of records. 322.7 Section 322.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.7 Exempt systems of...
32 CFR 322.7 - Exempt systems of records.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 32 National Defense 2 2012-07-01 2012-07-01 false Exempt systems of records. 322.7 Section 322.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.7 Exempt systems of...
32 CFR 322.7 - Exempt systems of records.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 32 National Defense 2 2014-07-01 2014-07-01 false Exempt systems of records. 322.7 Section 322.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.7 Exempt systems of...
32 CFR 322.7 - Exempt systems of records.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 32 National Defense 2 2011-07-01 2011-07-01 false Exempt systems of records. 322.7 Section 322.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.7 Exempt systems of...
Liu, Jianyun; Glosson, Nicole L; Du, Wenjun; Gervay-Hague, Jacquelyn; Brutkiewicz, Randy R
2013-01-01
CD1d-restricted T (natural killer T; NKT) cells are important for controlling herpesvirus infections. Interestingly, herpes simplex virus (HSV) can down-regulate CD1d-mediated activation of NKT cells. We have previously shown that the Thr322 residue in the cytoplasmic tail of human CD1d is important for its intracellular trafficking and functional expression. We proposed that the phosphorylation of T322 is a signal for CD1d lysosomal targeting and subsequent degradation. In the current study, we generated dual mutants by substituting the T322 and S323 residues of wild-type (WT) CD1d with Ala (non-phosphorylatable) or Asp (mimicking phosphorylation) and ectopically expressed them in human embryonic kidney 293 cells. We found that the surface expression levels of the CD1d mutants was in this order: T322AS323A > WT > T322A > S323A > S323D > T322D > T322DS323D. Our results therefore suggest that mimicking the phosphorylation of both T322 and S323 has a cumulative negative effect on the functional expression of CD1d. As previously reported, we also found that upon an HSV infection, antigen presentation by WT CD1d is reduced and the CD1d molecule is degraded. Interestingly, the T322A/S323A double mutation inhibited CD1d degradation and rescued CD1d-mediated antigen presentation following an HSV-1 infection. This suggests that the T322/S323 dyad may be phosphorylated, which then targets CD1d for lysosomal degradation post-infection as a means of immune evasion, explaining (at least in part) the reduced antigen presentation observed. Hence, our findings strongly suggest that T322 and S323 form a dual residue motif that can regulate the functional expression of CD1d during a viral infection. PMID:23710894
DOE Office of Scientific and Technical Information (OSTI.GOV)
BRISC is a developmental prototype for a nextgeneration systems-level integrated performance and safety code (IPSC) for nuclear reactors. Its development served to demonstrate how a lightweight multi-physics coupling approach can be used to tightly couple the physics models in several different physics codes (written in a variety of languages) into one integrated package for simulating accident scenarios in a liquid sodium cooled burner nuclear reactor. For example, the RIO Fluid Flow and Heat transfer code developed at Sandia (SNL: Chris Moen, Dept. 08005) is used in BRISC to model fluid flow and heat transfer, as well as conduction heat transfermore » in solids. Because BRISC is a prototype, its most practical application is as a foundation or starting point for developing a true production code. The sub-codes and the associated models and correlations currently employed within BRISC were chosen to cover the required application space and demonstrate feasibility, but were not optimized or validated against experimental data within the context of their use in BRISC.« less
Code of Federal Regulations, 2013 CFR
2013-07-01
... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Legal review. 3.22 Section 3.22 Money... OF DEPARTMENT OF TREASURY EMPLOYEES Claims Under the Small Claims Act § 3.22 Legal review. Claims filed under this subpart shall be forwarded to the legal division of the bureau or office out of whose...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Legal review. 3.22 Section 3.22 Money... OF DEPARTMENT OF TREASURY EMPLOYEES Claims Under the Small Claims Act § 3.22 Legal review. Claims filed under this subpart shall be forwarded to the legal division of the bureau or office out of whose...
Code of Federal Regulations, 2014 CFR
2014-07-01
... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Legal review. 3.22 Section 3.22 Money... OF DEPARTMENT OF TREASURY EMPLOYEES Claims Under the Small Claims Act § 3.22 Legal review. Claims filed under this subpart shall be forwarded to the legal division of the bureau or office out of whose...
Code of Federal Regulations, 2011 CFR
2011-07-01
... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Legal review. 3.22 Section 3.22 Money... OF DEPARTMENT OF TREASURY EMPLOYEES Claims Under the Small Claims Act § 3.22 Legal review. Claims filed under this subpart shall be forwarded to the legal division of the bureau or office out of whose...
Code of Federal Regulations, 2012 CFR
2012-07-01
... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Legal review. 3.22 Section 3.22 Money... OF DEPARTMENT OF TREASURY EMPLOYEES Claims Under the Small Claims Act § 3.22 Legal review. Claims filed under this subpart shall be forwarded to the legal division of the bureau or office out of whose...
Sun, Lei; Yang, Xiaowei; Chen, Feifei; Li, Rongpeng; Li, Xuesong; Liu, Zhenxing; Gu, Yuyu; Gong, Xiaoyan; Liu, Zhonghua; Wei, Hua; Huang, Ying; Yuan, Sheng
2013-01-01
Fission yeast cells express Rpl32-2 highly while Rpl32-1 lowly in log phase; in contrast, expression of Rpl32-1 raises and reaches a peak level while Rpl32-2 is downregulated to a low basic level when cells enter into stationary phase. Overexpression of Rpl32-1 inhibits cell growth while overexpression of Rpl32-2 does not. Deleting rpl32-2 impairs cell growth more severely than deleting rpl32-1 does. Cell growth impaired by deleting either paralog can be rescued completely by reintroducing rpl32-2, but only partly by rpl32-1. Overexpression of Rpl32-1 inhibits cell division, yielding 4c DNA and multiple septa, while overexpressed Rpl32-2 promotes it. Transcriptomics analysis proved that Rpl32 paralogs regulate expression of a subset of genes related with cell division and stress response in a distinctive way. This functional difference of the two paralogs is due to their difference of 95th amino acid residue. The significance of a competitive inhibition between Rpl32 paralogs on their expression is discussed. PMID:23577148
NASA Astrophysics Data System (ADS)
Lim, Meng-Hui; Teoh, Andrew Beng Jin
2011-12-01
Biometric discretization derives a binary string for each user based on an ordered set of biometric features. This representative string ought to be discriminative, informative, and privacy protective when it is employed as a cryptographic key in various security applications upon error correction. However, it is commonly believed that satisfying the first and the second criteria simultaneously is not feasible, and a tradeoff between them is always definite. In this article, we propose an effective fixed bit allocation-based discretization approach which involves discriminative feature extraction, discriminative feature selection, unsupervised quantization (quantization that does not utilize class information), and linearly separable subcode (LSSC)-based encoding to fulfill all the ideal properties of a binary representation extracted for cryptographic applications. In addition, we examine a number of discriminative feature-selection measures for discretization and identify the proper way of setting an important feature-selection parameter. Encouraging experimental results vindicate the feasibility of our approach.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-27
.../Absecon Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US40-322 (Albany Avenue) across... Route 30/Absecon Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US40-322 (Albany... mean high water. US40-322 (Albany Avenue) Bridge The current operating regulation for the US40-322...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-21
... Thorofare, NJICW mile 67.2 and the US40-322 (Albany Avenue) across Inside Thorofare, NJICW mile 70.0, both... Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US40-322 (Albany Avenue) across Inside..., above mean high water. US40-322 (Albany Avenue) Bridge The current operating regulation for the US40-322...
8 CFR 322.4 - Who must appear for an interview on the application for citizenship?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Who must appear for an interview on the application for citizenship? 322.4 Section 322.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... CITIZENSHIP § 322.4 Who must appear for an interview on the application for citizenship? The U.S. citizen...
10 CFR 63.322 - Human intrusion scenario.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 10 Energy 2 2013-01-01 2013-01-01 false Human intrusion scenario. 63.322 Section 63.322 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Postclosure Public Health and Environmental Standards Human Intrusion...
10 CFR 63.322 - Human intrusion scenario.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 10 Energy 2 2014-01-01 2014-01-01 false Human intrusion scenario. 63.322 Section 63.322 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Postclosure Public Health and Environmental Standards Human Intrusion...
10 CFR 63.322 - Human intrusion scenario.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 10 Energy 2 2012-01-01 2012-01-01 false Human intrusion scenario. 63.322 Section 63.322 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Postclosure Public Health and Environmental Standards Human Intrusion...
10 CFR 63.322 - Human intrusion scenario.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 10 Energy 2 2011-01-01 2011-01-01 false Human intrusion scenario. 63.322 Section 63.322 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Postclosure Public Health and Environmental Standards Human Intrusion...
76 FR 73496 - Airworthiness Directives; Airbus Airplanes
Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-29
...) that applies to certain Airbus Model A330-201, -202, -203, -223, -243, -301, -302, -303, -321, -322..., -322, -323, -341, -342, and -343 airplanes, all serial numbers, except those on which Airbus... Service Information (g) For Model A330-201, -202, -203, -223, -243, -301, -321, - 322, -323, -341, -342...
8 CFR 322.2 - Who is eligible for citizenship?
Code of Federal Regulations, 2010 CFR
2010-01-01
... Section 322.2 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS CHILD BORN... eligible for citizenship? (a) General. A child will be eligible for citizenship under section 322 of the Act, if the following conditions have been fulfilled: (1) The child has at least one United States...
10 CFR 1021.322 - Findings of no significant impact.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 4 2010-01-01 2010-01-01 false Findings of no significant impact. 1021.322 Section 1021... PROCEDURES Implementing Procedures § 1021.322 Findings of no significant impact. (a) DOE shall prepare a... the impacts of the proposed action not significant, beyond those mitigations that are integral...
7 CFR 322.28 - General requirements; restricted articles.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements; restricted articles. 322.28... EQUIPMENT Importation and Transit of Restricted Articles § 322.28 General requirements; restricted articles. (a) The following articles from any region are restricted articles: (1) Dead bees of any genus; (2...
7 CFR 322.28 - General requirements; restricted articles.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false General requirements; restricted articles. 322.28... EQUIPMENT Importation and Transit of Restricted Articles § 322.28 General requirements; restricted articles. (a) The following articles from any region are restricted articles: (1) Dead bees of any genus; (2...
7 CFR 322.28 - General requirements; restricted articles.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false General requirements; restricted articles. 322.28... EQUIPMENT Importation and Transit of Restricted Articles § 322.28 General requirements; restricted articles. (a) The following articles from any region are restricted articles: (1) Dead bees of any genus; (2...
7 CFR 322.28 - General requirements; restricted articles.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false General requirements; restricted articles. 322.28... EQUIPMENT Importation and Transit of Restricted Articles § 322.28 General requirements; restricted articles. (a) The following articles from any region are restricted articles: (1) Dead bees of any genus; (2...
7 CFR 322.28 - General requirements; restricted articles.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false General requirements; restricted articles. 322.28... EQUIPMENT Importation and Transit of Restricted Articles § 322.28 General requirements; restricted articles. (a) The following articles from any region are restricted articles: (1) Dead bees of any genus; (2...
20 CFR 322.2 - General definition of remuneration.
Code of Federal Regulations, 2010 CFR
2010-04-01
... Section 322.2 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT... unemployment or a day of sickness, except as explained in § 322.9. (c) Supplemental unemployment or sickness... nongovernmental plan for unemployment or sickness insurance, as defined in part 323 of this chapter. Employer...
20 CFR 322.2 - General definition of remuneration.
Code of Federal Regulations, 2013 CFR
2013-04-01
... Section 322.2 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT... unemployment or a day of sickness, except as explained in § 322.9. (c) Supplemental unemployment or sickness... nongovernmental plan for unemployment or sickness insurance, as defined in part 323 of this chapter. Employer...
20 CFR 322.2 - General definition of remuneration.
Code of Federal Regulations, 2011 CFR
2011-04-01
... Section 322.2 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT... unemployment or a day of sickness, except as explained in § 322.9. (c) Supplemental unemployment or sickness... nongovernmental plan for unemployment or sickness insurance, as defined in part 323 of this chapter. Employer...
20 CFR 322.2 - General definition of remuneration.
Code of Federal Regulations, 2014 CFR
2014-04-01
... Section 322.2 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT... unemployment or a day of sickness, except as explained in § 322.9. (c) Supplemental unemployment or sickness... nongovernmental plan for unemployment or sickness insurance, as defined in part 323 of this chapter. Employer...
20 CFR 322.2 - General definition of remuneration.
Code of Federal Regulations, 2012 CFR
2012-04-01
... Section 322.2 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT... unemployment or a day of sickness, except as explained in § 322.9. (c) Supplemental unemployment or sickness... nongovernmental plan for unemployment or sickness insurance, as defined in part 323 of this chapter. Employer...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-21
... Thorofare, NJICW mile 67.2 and the US40-322 (Albany Avenue) across Inside Thorofare, NJICW mile 70.0, both... 67.2 and the US40-322 (Albany Avenue) across Inside Thorofare, NJICW mile 70.0, both at Atlantic City... high water. US40-322 (Albany Avenue) Bridge The current operating regulation for the US40-322 (Albany...
78 FR 65187 - Airworthiness Directives; Airbus Airplanes
Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-31
.... (c) Applicability This AD applies to Airbus Model A330-301, -302, -303, -321, - 322, -323, -341, -342..., - 321, -322, -323, -341, -342, and -343 airplanes); or A340-27-4175, Revision 01, dated June 13, 2013...-3179, Revision 01, dated June 13, 2013 (for Model A330-301, -302, -303, -321, -322, -323, -341, -342...
Code of Federal Regulations, 2014 CFR
2014-10-01
... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Definitions. 32.2 Section 32.2 Public Lands: Interior Office of the Secretary of the Interior GRANTS TO STATES FOR ESTABLISHING YOUNG ADULT... follows: (a) Act. The Comprehensive Employment and Training Act of 1973, as amended. (b) YACC. Young Adult...
9 CFR 322.2 - Export certificates; instructions concerning issuance.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Export certificates; instructions concerning issuance. 322.2 Section 322.2 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... concerning issuance. (a) Upon application of the exporter, the inspector in charge is authorized to issue...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Definitions. 32.2 Section 32.2 Public Lands: Interior Office of the Secretary of the Interior GRANTS TO STATES FOR ESTABLISHING YOUNG ADULT... follows: (a) Act. The Comprehensive Employment and Training Act of 1973, as amended. (b) YACC. Young Adult...
15 CFR 904.322 - Interim action.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Interim action. 904.322 Section 904... Sanctions and Denials Permit Sanction for Violations § 904.322 Interim action. (a) To protect marine resources during the pendency of an action under this subpart, in cases of willfulness, or as otherwise...
15 CFR 904.322 - Interim action.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Interim action. 904.322 Section 904... Sanctions and Denials Permit Sanction for Violations § 904.322 Interim action. (a) To protect marine resources during the pendency of an action under this subpart, in cases of willfulness, or as otherwise...
40 CFR 90.322 - Calibration of other equipment.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Calibration of other equipment. 90.322 Section 90.322 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... engineering practice. ...
75 FR 39863 - Airworthiness Directives; Airbus Model A310 Series Airplanes
Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-13
..., -322, -324, and -325 airplanes, certificated in any category. Subject (d) Air Transport Association... first. (ii) For A310-304, -322, -324, and -325 short range airplanes: Within 700 flight cycles or 1,900 flight hours after the effective date of this AD, whichever occurs first. (iii) For A310-304, -322, -324...
75 FR 54069 - U.S. Paralympics Monthly Assistance Allowance
Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-03
....) SUPPLEMENTARY INFORMATION: In 2008, Congress amended title 38, United States Code, to add a new section 322... assistance allowance. 38 U.S.C. 322. VA proposes to amend its regulations to implement the allowance. Under section 322, VA may provide an allowance to a veteran with a disability who is: (1) Invited by the USP to...
77 FR 50986 - Submission for OMB Review; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-23
... procedures for requesting such safeguard measures, for making its determinations under section 322(a) of the Act, and for providing relief under section 322(b) of the Act. In Proclamation No. 8818 (77 FR 29519... domestic textile or apparel industry, subject to section 322(b) of the Act. Affected Public: Individuals or...
78 FR 67102 - Submission for OMB Review; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-08
... requesting such safeguard measures, for making its determinations under section 322(a) of the Act, and for providing relief under section 322(b) of the Act. In Proclamation No. 8341 (74 FR 4105, January 22, 2009... apparel industry, subject to section 322(b) of the Act. Affected Public: Individuals or households...
75 FR 62760 - Submission for OMB Review; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-13
... procedures for requesting such safeguard measures, for making its determinations under section 322(a) of the Act, and for providing relief under section 322(b) of the Act. In Proclamation No. 8332 (73 FR 80289... domestic textile or apparel industry, subject to section 322(b) of the Act. Affected Public: Individuals or...
Federal Register 2010, 2011, 2012, 2013, 2014
2012-12-03
... Under Section 322, Form N-600K; Revision of a Currently Approved Collection ACTION: 60-Day Notice... Form/Collection: Application for Citizenship and Issuance of Certificate Under Section 322. (3) Agency... applications for citizenship under section 322 of the Immigration and Nationality Act. (5) An estimate of the...
75 FR 66659 - Airworthiness Directives; Airbus Model A310 Series Airplanes
Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-29
.... Applicability (c) This AD applies to all Airbus Model A310-203, -204, -221, - 222, -304, -322, [[Page 66661... first. (ii) For A310-304, -322, -324, and -325 short range airplanes: Within 700 flight cycles or 1,900 flight hours after the effective date of this AD, whichever occurs first. (iii) For A310-304, -322, -324...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false Documentation. 322.23 Section 322.23 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of Restricted...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false Documentation. 322.23 Section 322.23 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of Restricted...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false Documentation. 322.23 Section 322.23 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of Restricted...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Documentation. 322.23 Section 322.23 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of Restricted...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false Documentation. 322.23 Section 322.23 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of Restricted...
40 CFR 91.322 - Calibration of other equipment.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Calibration of other equipment. 91.322 Section 91.322 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... manufacturer or as necessary according to good engineering practice. ...
Code of Federal Regulations, 2010 CFR
2010-01-01
... documents should the United States citizen parent(s) file? 322.3 Section 322.3 Aliens and Nationality... should the United States citizen parent(s) file? (a) Application. An application for a certificate of... for Certificate of Citizenship, by the U.S. citizen parent(s). An application for a certificate of...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-13
... and Issuance of Certificate under Section 322. OMB Control No. 1615-0087. The Department of Homeland...) Title of the Form/Collection: Application for Citizenship and Issuance of Certificate under Section 322... citizenship under section 322 of the Immigration and Nationality Act. (5) An estimate of the total number of...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-29
... and issuance of certificate under section 322. OMB Control No. 1615-0087. The Department of Homeland...) Title of the Form/Collection: Application for Citizenship and Issuance of Certificate under Section 322... citizenship under section 322 of the Immigration and Nationality Act. (5) An estimate of the total number of...
42 CFR 436.322 - Medically needy coverage of the disabled.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 42 Public Health 4 2012-10-01 2012-10-01 false Medically needy coverage of the disabled. 436.322... Optional Coverage of the Medically Needy § 436.322 Medically needy coverage of the disabled. If the agency provides Medicaid to the medically needy, it may provide Medicaid to disabled individuals who meet— (a) The...
42 CFR 436.322 - Medically needy coverage of the disabled.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 4 2010-10-01 2010-10-01 false Medically needy coverage of the disabled. 436.322... Optional Coverage of the Medically Needy § 436.322 Medically needy coverage of the disabled. If the agency provides Medicaid to the medically needy, it may provide Medicaid to disabled individuals who meet— (a) The...
42 CFR 436.322 - Medically needy coverage of the disabled.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 42 Public Health 4 2011-10-01 2011-10-01 false Medically needy coverage of the disabled. 436.322... Optional Coverage of the Medically Needy § 436.322 Medically needy coverage of the disabled. If the agency provides Medicaid to the medically needy, it may provide Medicaid to disabled individuals who meet— (a) The...
42 CFR 436.322 - Medically needy coverage of the disabled.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 42 Public Health 4 2013-10-01 2013-10-01 false Medically needy coverage of the disabled. 436.322... Optional Coverage of the Medically Needy § 436.322 Medically needy coverage of the disabled. If the agency provides Medicaid to the medically needy, it may provide Medicaid to disabled individuals who meet— (a) The...
42 CFR 436.322 - Medically needy coverage of the disabled.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 42 Public Health 4 2014-10-01 2014-10-01 false Medically needy coverage of the disabled. 436.322... Optional Coverage of the Medically Needy § 436.322 Medically needy coverage of the disabled. If the agency provides Medicaid to the medically needy, it may provide Medicaid to disabled individuals who meet— (a) The...
8 CFR 322.5 - What happens if the application is approved or denied by the Service?
Code of Federal Regulations, 2010 CFR
2010-01-01
... or denied by the Service? 322.5 Section 322.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS CHILD BORN OUTSIDE THE UNITED STATES; REQUIREMENTS FOR APPLICATION FOR CERTIFICATE OF... certificate of citizenship. The child is a citizen as of the date of approval and administration of the oath...
40 CFR 86.322-79 - NDIR CO2 rejection ratio check.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 19 2012-07-01 2012-07-01 false NDIR CO2 rejection ratio check. 86.322... PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission....322-79 NDIR CO2 rejection ratio check. (a) Zero and span the analyzer on the lowest range that will be...
40 CFR 86.322-79 - NDIR CO2 rejection ratio check.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 19 2013-07-01 2013-07-01 false NDIR CO2 rejection ratio check. 86.322... PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission....322-79 NDIR CO2 rejection ratio check. (a) Zero and span the analyzer on the lowest range that will be...
40 CFR 86.322-79 - NDIR CO2 rejection ratio check.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 18 2011-07-01 2011-07-01 false NDIR CO2 rejection ratio check. 86.322... PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission....322-79 NDIR CO2 rejection ratio check. (a) Zero and span the analyzer on the lowest range that will be...
The paper gives results of an experimental investigation at 32.2 C condensing of warm-liquid defrost for commercial food display cases. A refrigeration test rig with two open cases and two reach-in cases was tested using warm-liquid defrost (WLD) at -34.4 C evaporating, 32.2 C co...
40 CFR 86.322-79 - NDIR CO2 rejection ratio check.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 18 2010-07-01 2010-07-01 false NDIR CO2 rejection ratio check. 86.322... PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission....322-79 NDIR CO2 rejection ratio check. (a) Zero and span the analyzer on the lowest range that will be...
7 CFR 322.22 - General requirements.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false General requirements. 322.22 Section 322.22 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of...
7 CFR 322.22 - General requirements.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false General requirements. 322.22 Section 322.22 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of...
7 CFR 322.22 - General requirements.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false General requirements. 322.22 Section 322.22 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of...
7 CFR 322.22 - General requirements.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false General requirements. 322.22 Section 322.22 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of...
7 CFR 322.17 - Mailed packages.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false Mailed packages. 322.17 Section 322.17 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
7 CFR 322.22 - General requirements.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements. 322.22 Section 322.22 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit of...
7 CFR 322.17 - Mailed packages.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Mailed packages. 322.17 Section 322.17 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
7 CFR 322.17 - Mailed packages.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false Mailed packages. 322.17 Section 322.17 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
7 CFR 322.17 - Mailed packages.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false Mailed packages. 322.17 Section 322.17 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
7 CFR 322.17 - Mailed packages.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false Mailed packages. 322.17 Section 322.17 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
7 CFR 51.322 - Metric conversion table.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 2 2012-01-01 2012-01-01 false Metric conversion table. 51.322 Section 51.322 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...
7 CFR 51.322 - Metric conversion table.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 2 2013-01-01 2013-01-01 false Metric conversion table. 51.322 Section 51.322 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...
7 CFR 51.322 - Metric conversion table.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 2 2014-01-01 2014-01-01 false Metric conversion table. 51.322 Section 51.322 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...
7 CFR 51.322 - Metric conversion table.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 2 2011-01-01 2011-01-01 false Metric conversion table. 51.322 Section 51.322 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...
7 CFR 51.322 - Metric conversion table.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 2 2010-01-01 2010-01-01 false Metric conversion table. 51.322 Section 51.322 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-21
...-201, -202, -203, - 223, -243, -301, -302, -303, -321, -322, -323, -341, -342, and -343 Airplanes...-201, -202, -203, -223, -243, -301, -302, -303, -321, -322, -323, - 341, -342, and -343 airplanes... through 270714 inclusive. (1) Model A330-201, -202, -203, -223, -243, -301, -302, -303, - 321, -322, -323...
76 FR 14282 - U.S. Paralympics Monthly Assistance Allowance
Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-16
... reside at a USP training center. Congress authorized this allowance in 38 U.S.C. 322. As explained in the proposed rule, under section 322, VA may provide an allowance to a disabled veteran who is: (1) Invited by... veterans for this purpose, we note that Congress has already authorized this benefit under 38 U.S.C. 322(d...
77 FR 31342 - Application To Export Electric Energy; Emera Energy Services Subsidiaries
Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-25
... DEPARTMENT OF ENERGY [OE Docket No. EA-321-A, EA-322-A, EA-323-A, EA-324-A and EA-325-A...)). On April 19, 2007, the Department of Energy (DOE) issued Order No. EA-321, EA-322, EA-323, EA-324 and... Canada as power marketers for a five-year term. The current export authorities in Order No EA-321, EA-322...
7 CFR 322.32 - Mailed packages.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false Mailed packages. 322.32 Section 322.32 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.20 - Ports of entry.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false Ports of entry. 322.20 Section 322.20 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
7 CFR 322.32 - Mailed packages.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Mailed packages. 322.32 Section 322.32 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.32 - Mailed packages.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false Mailed packages. 322.32 Section 322.32 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.20 - Ports of entry.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Ports of entry. 322.20 Section 322.20 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
7 CFR 322.20 - Ports of entry.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false Ports of entry. 322.20 Section 322.20 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
7 CFR 322.32 - Mailed packages.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false Mailed packages. 322.32 Section 322.32 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.20 - Ports of entry.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false Ports of entry. 322.20 Section 322.20 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
7 CFR 322.32 - Mailed packages.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false Mailed packages. 322.32 Section 322.32 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.20 - Ports of entry.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false Ports of entry. 322.20 Section 322.20 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-30
... temporary deviation from the operating schedule that governs the draw of the US40-322 (Albany Avenue) Bridge... from the current operating regulations of the US40-322 (Albany Avenue) Bridge across Inside Thorofare... temporary deviation, the US40-322 (Albany Avenue) Bridge will remain in the closed position from 6 a.m...
75 FR 26183 - Procedures for Transportation Workplace Drug and Alcohol Testing Programs
Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-11
... Omnibus Transportation Employee Testing Act of 1991 (49 U.S.C. 102, 301, 322, 5331, 20140, 31306, and 45101 et seq.) and the Department of Transportation Act (49 U.S.C. 322). This proposed rule is a non... follows: Authority: 49 U.S.C. 102, 301, 322, 5331, 20140, 31306, and 45101 et seq. 2. In Appendix G to...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-22
.../Absecon Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US 40-322 (Albany Avenue) Bridge... Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US 40-322 (Albany Avenue) Bridge across... bridge need only open on the hour from 7 a.m. to 11 p.m. The US 40-322 (Albany Avenue Bridge) is a...
28 CFR 115.322 - Policies to ensure referrals of allegations for investigations.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Policies to ensure referrals of allegations for investigations. 115.322 Section 115.322 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Responsive...
28 CFR 115.322 - Policies to ensure referrals of allegations for investigations.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Policies to ensure referrals of allegations for investigations. 115.322 Section 115.322 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Responsive...
28 CFR 115.322 - Policies to ensure referrals of allegations for investigations.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Policies to ensure referrals of allegations for investigations. 115.322 Section 115.322 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Responsive...
7 CFR 322.35 - Ports of entry.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Ports of entry. 322.35 Section 322.35 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.19 - Inspection; refusal of entry.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Inspection; refusal of entry. 322.19 Section 322.19 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...
7 CFR 322.34 - Inspection; refusal of entry.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Inspection; refusal of entry. 322.34 Section 322.34 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and...
7 CFR 322.35 - Ports of entry.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false Ports of entry. 322.35 Section 322.35 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.27 - Eligible ports for transit shipments.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false Eligible ports for transit shipments. 322.27 Section 322.27 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit...
7 CFR 322.34 - Inspection; refusal of entry.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false Inspection; refusal of entry. 322.34 Section 322.34 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and...
7 CFR 322.19 - Inspection; refusal of entry.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false Inspection; refusal of entry. 322.19 Section 322.19 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...
7 CFR 322.19 - Inspection; refusal of entry.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false Inspection; refusal of entry. 322.19 Section 322.19 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...
7 CFR 322.19 - Inspection; refusal of entry.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false Inspection; refusal of entry. 322.19 Section 322.19 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...
7 CFR 322.19 - Inspection; refusal of entry.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false Inspection; refusal of entry. 322.19 Section 322.19 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...
7 CFR 322.35 - Ports of entry.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false Ports of entry. 322.35 Section 322.35 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.34 - Inspection; refusal of entry.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false Inspection; refusal of entry. 322.34 Section 322.34 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and...
7 CFR 322.35 - Ports of entry.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false Ports of entry. 322.35 Section 322.35 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.27 - Eligible ports for transit shipments.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 5 2010-01-01 2010-01-01 false Eligible ports for transit shipments. 322.27 Section 322.27 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit...
7 CFR 322.27 - Eligible ports for transit shipments.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false Eligible ports for transit shipments. 322.27 Section 322.27 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit...
7 CFR 322.35 - Ports of entry.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 5 2013-01-01 2013-01-01 false Ports of entry. 322.35 Section 322.35 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...
7 CFR 322.27 - Eligible ports for transit shipments.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false Eligible ports for transit shipments. 322.27 Section 322.27 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit...
7 CFR 322.34 - Inspection; refusal of entry.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 5 2011-01-01 2011-01-01 false Inspection; refusal of entry. 322.34 Section 322.34 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and...
7 CFR 322.27 - Eligible ports for transit shipments.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 5 2014-01-01 2014-01-01 false Eligible ports for transit shipments. 322.27 Section 322.27 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit...
7 CFR 322.34 - Inspection; refusal of entry.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 5 2012-01-01 2012-01-01 false Inspection; refusal of entry. 322.34 Section 322.34 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 10 Energy 1 2011-01-01 2011-01-01 false Definitions. 32.2 Section 32.2 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER CERTAIN ITEMS CONTAINING BYPRODUCT MATERIAL... disposal, or nuclear material contained in any fuel assembly, subassembly, fuel rod, or fuel pellet...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 1 2010-01-01 2010-01-01 false Definitions. 32.2 Section 32.2 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER CERTAIN ITEMS CONTAINING BYPRODUCT MATERIAL... disposal, or nuclear material contained in any fuel assembly, subassembly, fuel rod, or fuel pellet...
30 CFR 75.322 - Harmful quantities of noxious gases.
Code of Federal Regulations, 2013 CFR
2013-07-01
... Section 75.322 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.322 Harmful... Governmental Industrial Hygienists in “Threshold Limit Values for Substance in Workroom Air” (1972). Detectors...
30 CFR 75.322 - Harmful quantities of noxious gases.
Code of Federal Regulations, 2011 CFR
2011-07-01
... Section 75.322 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.322 Harmful... Governmental Industrial Hygienists in “Threshold Limit Values for Substance in Workroom Air” (1972). Detectors...
20 CFR 322.9 - Subsidiary remuneration.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Subsidiary remuneration. 322.9 Section 322.9 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT... to be considered as days of unemployment or days of sickness. (d) Substantially less than full time...
20 CFR 322.9 - Subsidiary remuneration.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Subsidiary remuneration. 322.9 Section 322.9 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT... to be considered as days of unemployment or days of sickness. (d) Substantially less than full time...
20 CFR 322.9 - Subsidiary remuneration.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Subsidiary remuneration. 322.9 Section 322.9 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT... to be considered as days of unemployment or days of sickness. (d) Substantially less than full time...
20 CFR 322.9 - Subsidiary remuneration.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Subsidiary remuneration. 322.9 Section 322.9 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT... to be considered as days of unemployment or days of sickness. (d) Substantially less than full time...
Hybrid 3D model for the interaction of plasma thruster plumes with nearby objects
NASA Astrophysics Data System (ADS)
Cichocki, Filippo; Domínguez-Vázquez, Adrián; Merino, Mario; Ahedo, Eduardo
2017-12-01
This paper presents a hybrid particle-in-cell (PIC) fluid approach to model the interaction of a plasma plume with a spacecraft and/or any nearby object. Ions and neutrals are modeled with a PIC approach, while electrons are treated as a fluid. After a first iteration of the code, the domain is split into quasineutral and non-neutral regions, based on non-neutrality criteria, such as the relative charge density and the Debye length-to-cell size ratio. At the material boundaries of the former quasineutral region, a dedicated algorithm ensures that the Bohm condition is met. In the latter non-neutral regions, the electron density and electric potential are obtained by solving the coupled electron momentum balance and Poisson equations. Boundary conditions for both the electric current and potential are finally obtained with a plasma sheath sub-code and an equivalent circuit model. The hybrid code is validated by applying it to a typical plasma plume-spacecraft interaction scenario, and the physics and capabilities of the model are finally discussed.
42 CFR 495.322 - FFP for reasonable administrative expenses.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 5 2010-10-01 2010-10-01 false FFP for reasonable administrative expenses. 495.322 Section 495.322 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY...
31 CFR 29.322 - Disability benefits.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Disability benefits. 29.322 Section 29.322 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER CERTAIN DISTRICT OF COLUMBIA RETIREMENT PROGRAMS Split Benefits Service Performed After June 30...
31 CFR 29.322 - Disability benefits.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Disability benefits. 29.322 Section 29.322 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER CERTAIN DISTRICT OF COLUMBIA RETIREMENT PROGRAMS Split Benefits Service Performed After June 30...
31 CFR 29.322 - Disability benefits.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Disability benefits. 29.322 Section 29.322 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER CERTAIN DISTRICT OF COLUMBIA RETIREMENT PROGRAMS Split Benefits Service Performed After June 30...
miR-322 stabilizes MEK1 expression to inhibit RAF/MEK/ERK pathway activation in cartilage.
Bluhm, Björn; Ehlen, Harald W A; Holzer, Tatjana; Georgieva, Veronika S; Heilig, Juliane; Pitzler, Lena; Etich, Julia; Bortecen, Toman; Frie, Christian; Probst, Kristina; Niehoff, Anja; Belluoccio, Daniele; Van den Bergen, Jocelyn; Brachvogel, Bent
2017-10-01
Cartilage originates from mesenchymal cell condensations that differentiate into chondrocytes of transient growth plate cartilage or permanent cartilage of the articular joint surface and trachea. MicroRNAs fine-tune the activation of entire signaling networks and thereby modulate complex cellular responses, but so far only limited data are available on miRNAs that regulate cartilage development. Here, we characterize a miRNA that promotes the biosynthesis of a key component in the RAF/MEK/ERK pathway in cartilage. Specifically, by transcriptome profiling we identified miR-322 to be upregulated during chondrocyte differentiation. Among the various miR-322 target genes in the RAF/MEK/ERK pathway, only Mek1 was identified as a regulated target in chondrocytes. Surprisingly, an increased concentration of miR-322 stabilizes Mek1 mRNA to raise protein levels and dampen ERK1/2 phosphorylation, while cartilage-specific inactivation of miR322 in mice linked the loss of miR-322 to decreased MEK1 levels and to increased RAF/MEK/ERK pathway activation. Such mice died perinatally due to tracheal growth restriction and respiratory failure. Hence, a single miRNA can stimulate the production of an inhibitory component of a central signaling pathway to impair cartilage development. © 2017. Published by The Company of Biologists Ltd.
Code of Federal Regulations, 2010 CFR
2010-07-01
... technology currently available. 436.322 Section 436.322 Protection of Environment ENVIRONMENTAL PROTECTION... reduction attainable by the application of the best practicable control technology currently available... application of the best practicable control technology currently available (BPT): For operations not employing...
9 CFR 322.3 - Transferring products for export.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Transferring products for export. 322... INSPECTION AND CERTIFICATION EXPORTS 1 § 322.3 Transferring products for export. When inspected and passed products for export are transferred from tank cars to other containers on vessels, such transfer shall be...
30 CFR 75.322 - Harmful quantities of noxious gases.
Code of Federal Regulations, 2014 CFR
2014-07-01
..._federal_regulations/ibr_locations.html. [61 FR 26442, May 28, 1996, as amended at 67 FR 38386, June 4... Section 75.322 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.322 Harmful...
30 CFR 75.322 - Harmful quantities of noxious gases.
Code of Federal Regulations, 2012 CFR
2012-07-01
..._federal_regulations/ibr_locations.html. [61 FR 26442, May 28, 1996, as amended at 67 FR 38386, June 4... Section 75.322 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.322 Harmful...
10 CFR 2.322 - Special assistants to the presiding officer.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 1 2010-01-01 2010-01-01 false Special assistants to the presiding officer. 2.322 Section 2.322 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Rules of General Applicability: Hearing Requests, Petitions To Intervene, Availability of Documents, Selection of Specific Hearin...
7 CFR 322.13 - General requirements; restricted organisms.
Code of Federal Regulations, 2010 CFR
2010-01-01
... HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING... region other than those listed in § 322.4(b); and (4) Bees other than honeybees, in any life stage, from any region other than those listed in § 322.4(c) or any species of bee other than those listed in...
7 CFR 322.13 - General requirements; restricted organisms.
Code of Federal Regulations, 2013 CFR
2013-01-01
... HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING... region other than those listed in § 322.4(b); and (4) Bees other than honeybees, in any life stage, from any region other than those listed in § 322.4(c) or any species of bee other than those listed in...
7 CFR 322.13 - General requirements; restricted organisms.
Code of Federal Regulations, 2014 CFR
2014-01-01
... HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING... region other than those listed in § 322.4(b); and (4) Bees other than honeybees, in any life stage, from any region other than those listed in § 322.4(c) or any species of bee other than those listed in...
7 CFR 322.13 - General requirements; restricted organisms.
Code of Federal Regulations, 2012 CFR
2012-01-01
... HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING... region other than those listed in § 322.4(b); and (4) Bees other than honeybees, in any life stage, from any region other than those listed in § 322.4(c) or any species of bee other than those listed in...
7 CFR 322.13 - General requirements; restricted organisms.
Code of Federal Regulations, 2011 CFR
2011-01-01
... HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING... region other than those listed in § 322.4(b); and (4) Bees other than honeybees, in any life stage, from any region other than those listed in § 322.4(c) or any species of bee other than those listed in...
42 CFR 403.322 - Termination of agreements for Medicare recognition of State systems.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 2 2010-10-01 2010-10-01 false Termination of agreements for Medicare recognition of State systems. 403.322 Section 403.322 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Recognition of State...
Bharathi, Sivakama S.; Zhang, Yuxun; Mohsen, Al-Walid; Uppala, Radha; Balasubramani, Manimalha; Schreiber, Emanuel; Uechi, Guy; Beck, Megan E.; Rardin, Matthew J.; Vockley, Jerry; Verdin, Eric; Gibson, Bradford W.; Hirschey, Matthew D.; Goetzman, Eric S.
2013-01-01
Long-chain acyl-CoA dehydrogenase (LCAD) is a key mitochondrial fatty acid oxidation enzyme. We previously demonstrated increased LCAD lysine acetylation in SIRT3 knockout mice concomitant with reduced LCAD activity and reduced fatty acid oxidation. To study the effects of acetylation on LCAD and determine sirtuin 3 (SIRT3) target sites, we chemically acetylated recombinant LCAD. Acetylation impeded substrate binding and reduced catalytic efficiency. Deacetylation with recombinant SIRT3 partially restored activity. Residues Lys-318 and Lys-322 were identified as SIRT3-targeted lysines. Arginine substitutions at Lys-318 and Lys-322 prevented the acetylation-induced activity loss. Lys-318 and Lys-322 flank residues Arg-317 and Phe-320, which are conserved among all acyl-CoA dehydrogenases and coordinate the enzyme-bound FAD cofactor in the active site. We propose that acetylation at Lys-318/Lys-322 causes a conformational change which reduces hydride transfer from substrate to FAD. Medium-chain acyl-CoA dehydrogenase and acyl-CoA dehydrogenase 9, two related enzymes with lysines at positions equivalent to Lys-318/Lys-322, were also efficiently deacetylated by SIRT3 following chemical acetylation. These results suggest that acetylation/deacetylation at Lys-318/Lys-322 is a mode of regulating fatty acid oxidation. The same mechanism may regulate other acyl-CoA dehydrogenases. PMID:24121500
Federal Register 2010, 2011, 2012, 2013, 2014
2011-08-11
.../Abescon Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US 40-322 (Albany Avenue) Bridge... Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US 40-322 (Albany Avenue) Bridge across... and unlimited in the open position. The current operating regulation for the US 40-322 (Albany Avenue...
31 CFR 515.322 - Authorized trade territory; member of the authorized trade territory.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Authorized trade territory; member of the authorized trade territory. 515.322 Section 515.322 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS General...
31 CFR 515.322 - Authorized trade territory; member of the authorized trade territory.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Authorized trade territory; member of the authorized trade territory. 515.322 Section 515.322 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS General...
31 CFR 515.322 - Authorized trade territory; member of the authorized trade territory.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Authorized trade territory; member of the authorized trade territory. 515.322 Section 515.322 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS General...
31 CFR 515.322 - Authorized trade territory; member of the authorized trade territory.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Authorized trade territory; member of the authorized trade territory. 515.322 Section 515.322 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS General...
31 CFR 500.322 - Authorized trade territory; member of the authorized trade territory.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Authorized trade territory; member of the authorized trade territory. 500.322 Section 500.322 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN ASSETS CONTROL REGULATIONS General...
31 CFR 515.322 - Authorized trade territory; member of the authorized trade territory.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Authorized trade territory; member of the authorized trade territory. 515.322 Section 515.322 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS General...
46 CFR 183.322 - Multiple generators.
Code of Federal Regulations, 2010 CFR
2010-10-01
...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service power, the following requirements...
46 CFR 183.322 - Multiple generators.
Code of Federal Regulations, 2012 CFR
2012-10-01
...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service power, the following requirements...
46 CFR 183.322 - Multiple generators.
Code of Federal Regulations, 2014 CFR
2014-10-01
...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service power, the following requirements...
46 CFR 183.322 - Multiple generators.
Code of Federal Regulations, 2011 CFR
2011-10-01
...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service power, the following requirements...
46 CFR 183.322 - Multiple generators.
Code of Federal Regulations, 2013 CFR
2013-10-01
...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service power, the following requirements...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-10
.../Absecon Boulevard Bridge across Beach Thorofare, NJICW mile 67.2, and the US40-322 (Albany Avenue) across... Bridge across Beach Thorofare, NJICW mile 67.2, and the US40-322 (Albany Avenue) across Inside Thorofare...-type bridge is 20 feet above mean high water. US40-322 (Albany Avenue) Bridge The current operating...
50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?
Code of Federal Regulations, 2012 CFR
2012-10-01
... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...
50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?
Code of Federal Regulations, 2014 CFR
2014-10-01
... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...
50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?
Code of Federal Regulations, 2010 CFR
2010-10-01
... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...
50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?
Code of Federal Regulations, 2013 CFR
2013-10-01
... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...
50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?
Code of Federal Regulations, 2011 CFR
2011-10-01
... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...
78 FR 14162 - Airworthiness Directives; Airbus Airplanes
Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-05
... Airbus Model A310-203, -204, -222, -304, -322, and -324 airplanes. This AD was prompted by a design... Airbus Model A310-203, -204, -222, -304, - 322, and -324 airplanes, certificated in any category...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-08-12
...) bridges: The Route 30/Abescon Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US 40-322... the US 40-322 (Albany Avenue) Bridge across Inside Thorofare, NJICW mile 70.0, both at Atlantic City... schedule for the bridge is set out in 33 CFR 117.733(e) and was last amended in April 2009. The US 40-322...
Beam Energy Dependence of the Third Harmonic of Azimuthal Correlations in Au +Au Collisions at RHIC
NASA Astrophysics Data System (ADS)
Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alekseev, I.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Attri, A.; Averichev, G. S.; Bai, X.; Bairathi, V.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bhattarai, P.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Bouchet, J.; Brandenburg, J. D.; Brandin, A. V.; Bunzarov, I.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Campbell, J. M.; Cebra, D.; Chakaberia, I.; Chaloupka, P.; Chang, Z.; Chatterjee, A.; Chattopadhyay, S.; Chen, J. H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H. J.; Das, S.; De Silva, L. C.; Debbe, R. R.; Dedovich, T. G.; Deng, J.; Derevschikov, A. A.; di Ruzza, B.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J. L.; Draper, J. E.; Du, C. M.; Dunkelberger, L. E.; Dunlop, J. C.; Efimov, L. G.; Engelage, J.; Eppley, G.; Esha, R.; Evdokimov, O.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Fedorisin, J.; Feng, Z.; Filip, P.; Fisyak, Y.; Flores, C. E.; Fulek, L.; Gagliardi, C. A.; Garand, D.; Geurts, F.; Gibson, A.; Girard, M.; Greiner, L.; Grosnick, D.; Gunarathne, D. S.; Guo, Y.; Gupta, S.; Gupta, A.; Guryn, W.; Hamad, A. I.; Hamed, A.; Haque, R.; Harris, J. W.; He, L.; Heppelmann, S.; Heppelmann, S.; Hirsch, A.; Hoffmann, G. W.; Horvat, S.; Huang, T.; Huang, X.; Huang, B.; Huang, H. Z.; Huck, P.; Humanic, T. J.; Igo, G.; Jacobs, W. W.; Jang, H.; Jentsch, A.; Jia, J.; Jiang, K.; Judd, E. G.; Kabana, S.; Kalinkin, D.; Kang, K.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Khan, Z. H.; Kikoła, D. P.; Kisel, I.; Kisiel, A.; Kochenda, L.; Koetke, D. D.; Kosarzewski, L. K.; Kraishan, A. F.; Kravtsov, P.; Krueger, K.; Kumar, L.; Lamont, M. A. C.; Landgraf, J. M.; Landry, K. D.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, X.; Li, C.; Li, X.; Li, Y.; Li, W.; Lin, T.; Lisa, M. A.; Liu, F.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, X.; Ma, R.; Ma, G. L.; Ma, Y. G.; Ma, L.; Magdy, N.; Majka, R.; Manion, A.; Margetis, S.; Markert, C.; Matis, H. S.; McDonald, D.; McKinzie, S.; Meehan, K.; Mei, J. C.; Minaev, N. G.; Mioduszewski, S.; Mishra, D.; Mohanty, B.; Mondal, M. M.; Morozov, D. A.; Mustafa, M. K.; Nandi, B. K.; Nasim, Md.; Nayak, T. K.; Nigmatkulov, G.; Niida, T.; Nogach, L. V.; Noh, S. Y.; Novak, J.; Nurushev, S. B.; Odyniec, G.; Ogawa, A.; Oh, K.; Okorokov, V. A.; Olvitt, D.; Page, B. S.; Pak, R.; Pan, Y. X.; Pandit, Y.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Pile, P.; Pluta, J.; Poniatowska, K.; Porter, J.; Posik, M.; Poskanzer, A. M.; Pruthi, N. K.; Putschke, J.; Qiu, H.; Quintero, A.; Ramachandran, S.; Raniwala, S.; Raniwala, R.; Ray, R. L.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Sakrejda, I.; Salur, S.; Sandweiss, J.; Sarkar, A.; Schambach, J.; Scharenberg, R. P.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Seger, J.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Sharma, A.; Sharma, B.; Sharma, M. K.; Shen, W. Q.; Shi, Z.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Sikora, R.; Simko, M.; Singha, S.; Skoby, M. J.; Smirnov, N.; Smirnov, D.; Solyst, W.; Song, L.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Stepanov, M.; Stock, R.; Strikhanov, M.; Stringfellow, B.; Sumbera, M.; Summa, B.; Sun, Z.; Sun, X. M.; Sun, Y.; Surrow, B.; Svirida, D. N.; Tang, Z.; Tang, A. H.; Tarnowsky, T.; Tawfik, A.; Thäder, J.; Thomas, J. H.; Timmins, A. R.; Tlusty, D.; Todoroki, T.; Tokarev, M.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Tripathy, S. K.; Tsai, O. D.; Ullrich, T.; Underwood, D. G.; Upsal, I.; Van Buren, G.; van Nieuwenhuizen, G.; Vandenbroucke, M.; Varma, R.; Vasiliev, A. N.; Vertesi, R.; Videbæk, F.; Vokal, S.; Voloshin, S. A.; Vossen, A.; Wang, F.; Wang, G.; Wang, J. S.; Wang, H.; Wang, Y.; Wang, Y.; Webb, G.; Webb, J. C.; Wen, L.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y.; Xiao, Z. G.; Xie, W.; Xie, G.; Xin, K.; Xu, Y. F.; Xu, Q. H.; Xu, N.; Xu, H.; Xu, Z.; Xu, J.; Yang, S.; Yang, Y.; Yang, Y.; Yang, C.; Yang, Y.; Yang, Q.; Ye, Z.; Ye, Z.; Yepes, P.; Yi, L.; Yip, K.; Yoo, I.-K.; Yu, N.; Zbroszczyk, H.; Zha, W.; Zhang, X. P.; Zhang, Y.; Zhang, J.; Zhang, J.; Zhang, S.; Zhang, S.; Zhang, Z.; Zhang, J. B.; Zhao, J.; Zhong, C.; Zhou, L.; Zhu, X.; Zoulkarneeva, Y.; Zyzak, M.; STAR Collaboration
2016-03-01
We present results from a harmonic decomposition of two-particle azimuthal correlations measured with the STAR detector in Au +Au collisions for energies ranging from √{sN N }=7.7 to 200 GeV. The third harmonic v32{2 }=⟨cos 3 (ϕ1-ϕ2)⟩ , where ϕ1-ϕ2 is the angular difference in azimuth, is studied as a function of the pseudorapidity difference between particle pairs Δ η =η1-η2 . Nonzero v32{2 } is directly related to the previously observed large-Δ η narrow-Δ ϕ ridge correlations and has been shown in models to be sensitive to the existence of a low viscosity quark gluon plasma phase. For sufficiently central collisions, v32{2 } persist down to an energy of 7.7 GeV, suggesting that quark gluon plasma may be created even in these low energy collisions. In peripheral collisions at these low energies, however, v32{2 } is consistent with zero. When scaled by the pseudorapidity density of charged-particle multiplicity per participating nucleon pair, v32{2 } for central collisions shows a minimum near √{sN N }=20 GeV .
Babakhanyan, Anna; Leke, Rose G. F.; Salanti, Ali; Bobbili, Naveen; Gwanmesia, Philomina; Leke, Robert J. I.; Quakyi, Isabella A.; Chen, John J.; Taylor, Diane Wallace
2014-01-01
In pregnant women, Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA antigen bind to chondroitin sulfate A in the placenta causing placental malaria. The binding site of VAR2CSA is present in the ID1-ID2a region. This study sought to determine if pregnant Cameroonian women naturally acquire antibodies to ID1-ID2a and if antibodies to ID1-ID2a correlate with absence of placental malaria at delivery. Antibody levels to full-length VAR2CSA and ID1-ID2a were measured in plasma samples from 745 pregnant Cameroonian women, 144 Cameroonian men, and 66 US subjects. IgM levels and IgG avidity to ID1-ID2a were also determined. As expected, antibodies to ID1-ID2a were absent in US controls. Although pregnant Cameroonian women developed increasing levels of antibodies to full-length VAR2CSA during pregnancy, no increase in either IgM or IgG to ID1-ID2a was observed. Surprisingly, no differences in antibody levels to ID1-ID2a were detected between Cameroonian men and pregnant women. For example, in rural settings only 8–9% of males had antibodies to full-length VAR2CSA, but 90–96% had antibodies to ID1-ID2a. In addition, no significant difference in the avidity of IgG to ID1-ID2a was found between pregnant women and Cameroonian men, and no correlation between antibody levels at delivery and absence of placental malaria was found. Thus, the response to ID1-ID2a was not pregnancy specific, but predominantly against cross-reactivity epitopes, which may have been induced by other PfEMP1 antigens, malarial antigens, or microbes. Currently, ID1-ID2a is a leading vaccine candidate, since it binds to the CSA with the same affinity as the full-length molecule and elicits binding-inhibitory antibodies in animals. Further studies are needed to determine if the presence of naturally acquired cross-reactive antibodies in women living in malaria endemic countries will alter the response to ID1-ID2a following vaccination with ID1-ID2a. PMID:24505415
Dubey, S. K.; Duddelly, S.; Jangala, H.; Saha, R. N.
2013-01-01
A reliable, rapid and sensitive isocratic reverse phase high-performance liquid chromatography method has been developed and validated for assay of ketorolac tromethamine in tablets and ophthalmic dosage forms using diclofenac sodium as an internal standard. An isocratic separation of ketorolac tromethamine was achieved on Oyster BDS (150×4.6 mm i.d., 5 μm particle size) column using mobile phase of methanol:acetonitrile:sodium dihydrogen phosphate (20 mM; pH 5.5) (50:10:40, %v/v) at a flow rate of 1.0 ml/min. The eluents were monitored at 322 nm for ketorolac and at 282 nm for diclofenac sodium with a photodiode array detector. The retention times of ketorolac and diclofenac sodium were found to be 1.9 min and 4.6 min, respectively. Response was a linear function of drug concentration in the range of 0.01-15 μg/ml (R2=0.994; linear regression model using weighing factor 1/x2) with a limit of detection and quantification of 0.002 μg/ml and 0.007 μg/ml, respectively. The % recovery and % relative standard deviation values indicated the method was accurate and precise. PMID:23901166
64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET radiotracer targeting neuroblastoma and melanoma.
Vavere, Amy L; Butch, Elizabeth R; Dearling, Jason L J; Packard, Alan B; Navid, Fariba; Shulkin, Barry L; Barfield, Raymond C; Snyder, Scott E
2012-11-01
The hu14.18K322A variant of the GD2-targeting antibody hu14.18 has been shown to elicit a level of antibody-dependent cell-mediated cytotoxicity toward human neuroblastoma cells similar to that of the parent antibody. However, hu14.18K322A exhibited a decreased complement activation and associated pain, the dose-limiting toxicity in neuroblastoma immunotherapy. PET with a radiolabeled analog of the same antibody used in treatment will provide insight into the ability of hu14.18K322A to reach its target, as well as nontarget uptake that may cause side effects. Such antibody radiotracers might also provide a method for measuring GD2 expression in tumors, thus enabling the prediction of response to anti-GD2 therapy for individual patients. The conjugation of hu14.18K322A with p-NH(2)-Bn-DOTA was accomplished using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide with subsequent (64)Cu radiolabeling at 37°C for 30 min. Immunoreactivity of the conjugate was assessed by a dose-escalation blocking experiment measuring binding to purified GD2 versus GD1b as a negative control. Cell uptake and biodistribution studies in M21 (GD2-positive) and PC-3 (GD2-negative) tumor models were performed, as was small-animal PET/CT of M21 and PC-3 tumor-bearing mice. The labeling of (64)Cu-p-NH(2)-Bn-DOTA-hu14.18K322A was achieved at more than 95% radiochemical purity and a specific activity of 127-370 MBq/mg (3.4-10 mCi/mg) after chromatographic purification. Preliminary in vitro data demonstrated a greater than 6-fold selectivity of binding to GD2 versus GD1b and dose-dependent inhibition of binding by unmodified hu14.8K322A. In vivo data, including small-animal PET/CT, showed significant GD2-positive tumor-targeting ability, with a persistent 2-fold-higher uptake of radiotracer than in GD2-negative tumors. (64)Cu-p-NH(2)-Bn-DOTA-hu14.18K322A represents a novel PET radiotracer to facilitate clinical investigations of anti-GD2 immunotherapies and to complement other imaging modalities in the staging and treatment of neuroblastoma.
Use of DoD Architectural Framework in Support of JFIIT Assessments
2007-06-12
ACCA ASCA Div FSCA BCT/Regt FSCA Bn FSCA TACP TACP TACP JFO/Observer Friendly Forces Air RCA OV-1 for TA 3.2.2 Conduct Close Air Support OV-1 for TA...3.2.2 Conduct Close Air Support Ground RCA ISR FSCA/ ACCA CAS Aircraft FAC(A) Indirect Surface Fires Hostile Targets WOC TACP GLO Legend ACCA Air...FAC(A)/CAS Aircrew A3.1.4 Control CAS A3.2.1 Coordinate with WOC/ ACCA /ASCA/ACA A3.2.2 Coordinate with JTAC A3.2.3 Provide CAS A3.3.1 Coordinate with
Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-19
... and Issuance of Certificate under Section 322. The Department of Homeland Security, U.S. Citizenship... the Form/Collection: Application for Citizenship and Issuance of Certificate under Section 322. [[Page...
Bairagya, Hridoy R; Mukhopadhyay, Bishnu P; Sekar, K
2009-10-01
Inosine 5' monophosphate dehydrogenase (IMPDH II) is a key enzyme involved in the de novo biosynthesis pathway of purine nucleotides and is also considered to be an excellent target for cancer inhibitor design. The conserve R 322 residue (in human) is thought to play some role in the recognition of inhibitor and cofactor through the catalytic D 364 and N 303. The 15 ns simulation and the water dynamics of the three different PDB structures (1B3O, 1NF7, and 1NFB) of human IMPDH by CHARMM force field have clearly indicated the involvement of three conserved water molecules (W(L), W(M), and W(C)) in the recognition of catalytic residues (R 322, D 364, and N 303) to inhibitor and cofactor. Both the guanidine nitrogen atoms (NH1 and NH 2) of the R 322 have anchored the di- and mono-nucleotide (cofactor and inhibitor) binding domains via the conserved W(C) and W(L) water molecules. Another conserved water molecule WM seems to bridge the two domains including the R 322 and also the W(C) and W(L) through seven centers H-bonding coordination. The conserved water molecular triad (W(C)-W(M)-W(L)) in the protein complex may thought to play some important role in the recognition of inhibitor and cofactor to the protein through R 322 residue.
7 CFR 1205.322 - Establishment and membership.
Code of Federal Regulations, 2014 CFR
2014-01-01
... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Cotton Board § 1205.322 Establishment and membership. (a) There is hereby established a Cotton Board composed of: (1) Representatives of cotton...
7 CFR 1205.322 - Establishment and membership.
Code of Federal Regulations, 2010 CFR
2010-01-01
... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Cotton Board § 1205.322 Establishment and membership. (a) There is hereby established a Cotton Board composed of: (1) Representatives of cotton...
7 CFR 1205.322 - Establishment and membership.
Code of Federal Regulations, 2013 CFR
2013-01-01
... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Cotton Board § 1205.322 Establishment and membership. (a) There is hereby established a Cotton Board composed of: (1) Representatives of cotton...
7 CFR 1205.322 - Establishment and membership.
Code of Federal Regulations, 2012 CFR
2012-01-01
... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Cotton Board § 1205.322 Establishment and membership. (a) There is hereby established a Cotton Board composed of: (1) Representatives of cotton...
7 CFR 1205.322 - Establishment and membership.
Code of Federal Regulations, 2011 CFR
2011-01-01
... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Cotton Board § 1205.322 Establishment and membership. (a) There is hereby established a Cotton Board composed of: (1) Representatives of cotton...
On the Child's Status in the Democratic State: A Response to Mr. Schrag
ERIC Educational Resources Information Center
Cohen, Carl
1975-01-01
In response to SO 504 322, it is agreed that a chronological age criterion for voting is necessary but disagreement is found with the 15-year-old franchise. For journal availability, see SO 504 322. (ND)
"All the money in the world …" patient perspectives regarding the influence of financial incentives.
Reisinger, Heather Schacht; Brackett, Rachel Horner; Buzza, Colin D; Páez, Monica B Williams; Gourley, Ryan; Weg, Mark W Vander; Christensen, Alan J; Kaboli, Peter J
2011-12-01
To analyze patient perspectives of the use of financial incentives in a hypertension intervention. Study Setting. Twelve Veterans Affairs primary care clinics over a 9-month period. Qualitative semistructured interviews conducted with 54 hypertensive veterans participating in an intervention to promote guideline-consistent therapy. Intervention components included an intervention letter requesting patients talk with their providers, an offer of U.S.$20 to bring in the letter to their provider, and a health educator phone call. Semistructured interviews were conducted. Transcripts were coded for thematic content. The financial incentive theme was then subcoded for more detailed analysis. Most participants (n=48; 88.9 percent) stated the incentive had (or would have) no effect on their decision to initiate a discussion with their provider. Some participants articulated reservations about the effectiveness and/or appropriateness of financial incentives in health care decisions; however, a few expressed the opinion that there may be some potential benefits to the use of financial incentives if they encourage patients to be active in their health care. The findings of this study raise questions about the appropriateness and unintended consequences of employing patient-directed financial incentives in health care settings. © Health Research and Educational Trust.
Kusuhara, Hiroyuki; Takashima, Tadayuki; Fujii, Hisako; Takashima, Tsutomu; Tanaka, Masaaki; Ishii, Akira; Tazawa, Shusaku; Takahashi, Kazuhiro; Takahashi, Kayo; Tokai, Hidekichi; Yano, Tsuneo; Kataoka, Makoto; Inano, Akihiro; Yoshida, Suguru; Hosoya, Takamitsu; Sugiyama, Yuichi; Yamashita, Shinji; Hojo, Taisuke; Watanabe, Yasuyoshi
2017-12-01
The aim of the present study is to investigate the pharmacokinetics of our newly developed aromatase inhibitors (cetrozole and TMD-322) in healthy subjects by a cassette microdose strategy. A cocktail of cetrozole and TMD-322 was administered intravenously or orally (1.98 μg for each drug) to six healthy volunteers in a crossover fashion. Anastrozole (1.98 μg) was also included in the oral cocktail. Total body clearance and bioavailability were 12.1 ± 7.1 mL/min/kg and 34.9 ± 32.3% for cetrozole, and 16.8 ± 3.5 mL/min/kg and 18.4 ± 12.2% for TMD-322, respectively. The area under the plasma concentration-time curves of cetrozole and TMD-322 after oral administration was markedly lower than that of anastrozole because of their high hepatic clearance. Two subjects out of six exhibited 4- and 17-fold larger exposure of cetrozole than the others following intravenous and oral administration, respectively. Such variation was not observed for TMD-322 and anastrozole. Extensive metabolism of cetrozole and TMD-322 was observed in the CYP2C19 expression system among the test CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4). We report the first clinical investigation of our aromatase inhibitors by a cassette microdose strategy in healthy Japanese subjects. This strategy offers an optional approach for candidate selection as a phase zero study in drug development. Copyright © 2017. Published by Elsevier Ltd.
Observations of H1743-322 with the Sardinia Radio Telescope: upper limits
NASA Astrophysics Data System (ADS)
Egron, E.; Bachetti, M.; Pellizzoni, A.; Trois, A.; Iacolina, M. N.; Pilia, M.; Loru, S.; Navarrini, A.; Ballhausen, R.; Corbel, S.; Eikmann, W.; Fuerst, F.; Grinberg, V.; Kreykenbohm, I.; Marongiu, M.; Nowak, M.; Possenti, A.; Pottschmidt, K.; Rodriguez, J.; Wilms, J.
2016-03-01
A new outburst of the Galactic black hole low-mass X-ray binary H1743-322 was reported on 2016 February 28 using Swift/BAT (Lin et al., ATel #8751), less than a year after its previous outburst (#7652).
20 CFR 322.3 - Determining the days with respect to which remuneration is payable or accrues.
Code of Federal Regulations, 2010 CFR
2010-04-01
... REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.3 Determining the days with... unemployment or sickness. See § 332.6 of this chapter. (c) Guaranteed earnings. A payment under a plan which...
20 CFR 322.3 - Determining the days with respect to which remuneration is payable or accrues.
Code of Federal Regulations, 2013 CFR
2013-04-01
... REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.3 Determining the days with... unemployment or sickness. See § 332.6 of this chapter. (c) Guaranteed earnings. A payment under a plan which...
20 CFR 322.3 - Determining the days with respect to which remuneration is payable or accrues.
Code of Federal Regulations, 2014 CFR
2014-04-01
... REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.3 Determining the days with... unemployment or sickness. See § 332.6 of this chapter. (c) Guaranteed earnings. A payment under a plan which...
20 CFR 322.3 - Determining the days with respect to which remuneration is payable or accrues.
Code of Federal Regulations, 2012 CFR
2012-04-01
... REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.3 Determining the days with... unemployment or sickness. See § 332.6 of this chapter. (c) Guaranteed earnings. A payment under a plan which...
20 CFR 322.3 - Determining the days with respect to which remuneration is payable or accrues.
Code of Federal Regulations, 2011 CFR
2011-04-01
... REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.3 Determining the days with... unemployment or sickness. See § 332.6 of this chapter. (c) Guaranteed earnings. A payment under a plan which...
32 CFR 322.4 - Responsibilities.
Code of Federal Regulations, 2011 CFR
2011-07-01
... physical security requirements for the protection of personal information and ensure that such requirements... NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.4 Responsibilities. (a) The... Associate Director for Human Resources Services or designee shall: (1) Establish the physical security...
45 CFR 3.22 - Request for identification.
Code of Federal Regulations, 2011 CFR
2011-10-01
... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON THE NATIONAL INSTITUTES OF HEALTH FEDERAL ENCLAVE Traffic Regulations § 3.22 Request for... identification card or driver's license): (a) A traffic accident within the enclave; (b) The police officer...
45 CFR 3.22 - Request for identification.
Code of Federal Regulations, 2012 CFR
2012-10-01
... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON THE NATIONAL INSTITUTES OF HEALTH FEDERAL ENCLAVE Traffic Regulations § 3.22 Request for... identification card or driver's license): (a) A traffic accident within the enclave; (b) The police officer...
45 CFR 3.22 - Request for identification.
Code of Federal Regulations, 2014 CFR
2014-10-01
... Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON THE NATIONAL INSTITUTES OF HEALTH FEDERAL ENCLAVE Traffic Regulations § 3.22 Request for... identification card or driver's license): (a) A traffic accident within the enclave; (b) The police officer...
45 CFR 3.22 - Request for identification.
Code of Federal Regulations, 2013 CFR
2013-10-01
... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON THE NATIONAL INSTITUTES OF HEALTH FEDERAL ENCLAVE Traffic Regulations § 3.22 Request for... identification card or driver's license): (a) A traffic accident within the enclave; (b) The police officer...
7 CFR 322.9 - Mailed packages.
Code of Federal Regulations, 2014 CFR
2014-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.9 Mailed packages. (a) If you import a package of honeybees, honeybee germ plasm, or bees other than honeybees under...
7 CFR 322.9 - Mailed packages.
Code of Federal Regulations, 2011 CFR
2011-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.9 Mailed packages. (a) If you import a package of honeybees, honeybee germ plasm, or bees other than honeybees under...
7 CFR 322.9 - Mailed packages.
Code of Federal Regulations, 2010 CFR
2010-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.9 Mailed packages. (a) If you import a package of honeybees, honeybee germ plasm, or bees other than honeybees under...
7 CFR 322.9 - Mailed packages.
Code of Federal Regulations, 2012 CFR
2012-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.9 Mailed packages. (a) If you import a package of honeybees, honeybee germ plasm, or bees other than honeybees under...
7 CFR 322.9 - Mailed packages.
Code of Federal Regulations, 2013 CFR
2013-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.9 Mailed packages. (a) If you import a package of honeybees, honeybee germ plasm, or bees other than honeybees under...
NASA Astrophysics Data System (ADS)
Molla, Aslam Ali; Debnath, Dipak; Chakrabarti, Sandip Kumar; Mondal, Santanu; Jana, Arghajit; Chatterjee, Debjit
2016-07-01
The black hole X-ray binary H1743-322 has been observed almost during every X-ray mission since the inception of X-ray astronomy. Like other black hole candidates H1743-322 is highly variable. Using a self consistent accretion flow model (TCAF), we study spectral evolution during its 2010 & 2011 outbursts by keeping model normalization fixed to a value (14.5). As model normalization depends only on mass, distance and inclination angle of the black hole so, it should be a constant. This constant allows us to calculate mass of the black hole if we keep it frozen. The only uncertainty in mass and normalization measurements comes from the uncertainty of distance and inclination angle. Here we present spectral analysis of H1743-322 during 2010 and 2011 outburst and conclude that the mass of the black hole is within a range of 9 - 13 M_Sun.
1983-12-01
END IF 322 : C WRITE VAHIABLES, mCLDDING KEYWORDS, TO CATBUF 323: C 324: . CATX Bir70UT(CATLrH,CATBOT,112,rEOF) 325...SCORR.SD.SIZE,RC0RR,RD,RANGE 7012 . FORMAT(6F10.4) 91 92 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338...SIZEMX 320: 2013 FORMATC Max shot size:’,F10.4,’ Enter size:’) 118 321 322 323 14 324 2014 325 326 327 15 328 2015 329 330 331 16
Decreasing patient identification band errors by standardizing processes.
Walley, Susan Chu; Berger, Stephanie; Harris, Yolanda; Gallizzi, Gina; Hayes, Leslie
2013-04-01
Patient identification (ID) bands are an essential component in patient ID. Quality improvement methodology has been applied as a model to reduce ID band errors although previous studies have not addressed standardization of ID bands. Our specific aim was to decrease ID band errors by 50% in a 12-month period. The Six Sigma DMAIC (define, measure, analyze, improve, and control) quality improvement model was the framework for this study. ID bands at a tertiary care pediatric hospital were audited from January 2011 to January 2012 with continued audits to June 2012 to confirm the new process was in control. After analysis, the major improvement strategy implemented was standardization of styles of ID bands and labels. Additional interventions included educational initiatives regarding the new ID band processes and disseminating institutional and nursing unit data. A total of 4556 ID bands were audited with a preimprovement ID band error average rate of 9.2%. Significant variation in the ID band process was observed, including styles of ID bands. Interventions were focused on standardization of the ID band and labels. The ID band error rate improved to 5.2% in 9 months (95% confidence interval: 2.5-5.5; P < .001) and was maintained for 8 months. Standardization of ID bands and labels in conjunction with other interventions resulted in a statistical decrease in ID band error rates. This decrease in ID band error rates was maintained over the subsequent 8 months.
7 CFR 322.5 - General requirements.
Code of Federal Regulations, 2012 CFR
2012-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.5 General requirements. (a) All shipments of bees and honeybee germ plasm imported into the United States under this...
7 CFR 322.5 - General requirements.
Code of Federal Regulations, 2013 CFR
2013-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.5 General requirements. (a) All shipments of bees and honeybee germ plasm imported into the United States under this...
7 CFR 322.5 - General requirements.
Code of Federal Regulations, 2011 CFR
2011-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.5 General requirements. (a) All shipments of bees and honeybee germ plasm imported into the United States under this...
7 CFR 322.5 - General requirements.
Code of Federal Regulations, 2010 CFR
2010-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.5 General requirements. (a) All shipments of bees and honeybee germ plasm imported into the United States under this...
7 CFR 322.5 - General requirements.
Code of Federal Regulations, 2014 CFR
2014-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.5 General requirements. (a) All shipments of bees and honeybee germ plasm imported into the United States under this...
42 CFR 412.322 - Indirect medical education adjustment factor.
Code of Federal Regulations, 2010 CFR
2010-10-01
... Capital-Related Costs § 412.322 Indirect medical education adjustment factor. (a) Basic data. CMS...] Determination of Transition Period Payment Rates for Capital-Related Costs ... 42 Public Health 2 2010-10-01 2010-10-01 false Indirect medical education adjustment factor. 412...
Code of Federal Regulations, 2010 CFR
2010-04-01
...' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.1 Introduction. The Railroad Unemployment Insurance Act provides benefits for a qualified employee's days of unemployment or days of sickness, as defined in section 1(k) of the Act. Under that...
Code of Federal Regulations, 2013 CFR
2013-04-01
...' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.1 Introduction. The Railroad Unemployment Insurance Act provides benefits for a qualified employee's days of unemployment or days of sickness, as defined in section 1(k) of the Act. Under that...
Code of Federal Regulations, 2011 CFR
2011-04-01
...' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.1 Introduction. The Railroad Unemployment Insurance Act provides benefits for a qualified employee's days of unemployment or days of sickness, as defined in section 1(k) of the Act. Under that...
Code of Federal Regulations, 2012 CFR
2012-04-01
...' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.1 Introduction. The Railroad Unemployment Insurance Act provides benefits for a qualified employee's days of unemployment or days of sickness, as defined in section 1(k) of the Act. Under that...
Code of Federal Regulations, 2014 CFR
2014-04-01
...' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.1 Introduction. The Railroad Unemployment Insurance Act provides benefits for a qualified employee's days of unemployment or days of sickness, as defined in section 1(k) of the Act. Under that...
Iron Deficiency (ID) at Both Birth and 9 Months Predicts Right Frontal EEG Asymmetry in Infancy
Armony-Sivan, Rinat; Zhu, Bingquan; Clark, Katy M.; Richards, Blair; Ji, Chai; Kaciroti, Niko; Shao, Jie
2016-01-01
This study considered effects of timing and duration of iron deficiency (ID) on frontal EEG asymmetry in infancy. In healthy term Chinese infants, EEG was recorded at 9 months in three experimental conditions: baseline, peek-a-boo, and stranger approach. Eighty infants provided data for all conditions. Prenatal ID was defined as low cord ferritin or high ZPP/H. Postnatal ID was defined as ≥ two abnormal iron measures at 9 months. Study groups were pre- and postnatal ID, prenatal ID only, postnatal ID only, and not ID. GLM repeated measure analysis showed a main effect for iron group. The pre- and postnatal ID group had negative asymmetry scores, reflecting right frontal EEG asymmetry (mean ±SE: −.18 ±.07) versus prenatal ID only (.00 ±.04), postnatal ID only (.03 ±.04), and not ID (.02 ±.04). Thus, ID at both birth and 9 months was associated with right frontal EEG asymmetry, a neural correlate of behavioral withdrawal and negative emotions. PMID:26668100
Riedl, Sabrina; Rinner, Beate; Schaider, Helmut; Lohner, Karl; Zweytick, Dagmar
2014-10-01
Despite favorable advancements in therapy cancer is still not curative in many cases, which is often due to inadequate specificity for tumor cells. In this study derivatives of a short cationic peptide derived from the human host defense peptide lactoferricin were optimized in their selective toxicity towards cancer cells. We proved that the target of these peptides is the negatively charged membrane lipid phosphatidylserine (PS), specifically exposed on the surface of cancer cells. We have studied the membrane interaction of three peptides namely LF11-322, its N-acyl derivative 6-methyloctanoyl-LF11-322 and its retro repeat derivative R(etro)-DIM-P-LF11-322 with liposomes mimicking cancerous and non-cancerous cell membranes composed of PS and phosphatidylcholine (PC), respectively. Calorimetric and permeability studies showed that N-acylation and even more the repeat derivative of LF11-322 leads to strongly improved interaction with the cancer mimic PS, whereas only the N-acyl derivative also slightly affects PC. Tryptophan fluorescence of selective peptide R-DIM-P-LF11-322 revealed specific peptide penetration into the PS membrane interface and circular dichroism showed change of its secondary structure by increase of proportion of β-sheets just in the presence of the cancer mimic. Data correlated with in vitro studies with cell lines of human melanomas, their metastases and melanocytes, revealing R-DIM-P-LF11-322 to exhibit strongly increased specificity for cancer cells. This indicates the need of high affinity to the target PS, a minimum length and net positive charge, an adequate but moderate hydrophobicity, and capability of adoption of a defined structure exclusively in presence of the target membrane for high antitumor activity.
45 CFR 3.22 - Request for identification.
Code of Federal Regulations, 2010 CFR
2010-10-01
... identification card or driver's license): (a) A traffic accident within the enclave; (b) The police officer... TRAFFIC ON THE NATIONAL INSTITUTES OF HEALTH FEDERAL ENCLAVE Traffic Regulations § 3.22 Request for... (see § 3.41). A driver of a motor vehicle involved in an accident within the enclave shall also exhibit...
7 CFR 322.10 - Inspection; refusal of entry.
Code of Federal Regulations, 2014 CFR
2014-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.10 Inspection; refusal of entry. (a) Shipments of honeybees, honeybee germ plasm, and bees other than honeybees...
7 CFR 322.10 - Inspection; refusal of entry.
Code of Federal Regulations, 2010 CFR
2010-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.10 Inspection; refusal of entry. (a) Shipments of honeybees, honeybee germ plasm, and bees other than honeybees...
7 CFR 322.10 - Inspection; refusal of entry.
Code of Federal Regulations, 2012 CFR
2012-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.10 Inspection; refusal of entry. (a) Shipments of honeybees, honeybee germ plasm, and bees other than honeybees...
7 CFR 322.10 - Inspection; refusal of entry.
Code of Federal Regulations, 2011 CFR
2011-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.10 Inspection; refusal of entry. (a) Shipments of honeybees, honeybee germ plasm, and bees other than honeybees...
7 CFR 322.10 - Inspection; refusal of entry.
Code of Federal Regulations, 2013 CFR
2013-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.10 Inspection; refusal of entry. (a) Shipments of honeybees, honeybee germ plasm, and bees other than honeybees...
Code of Federal Regulations, 2012 CFR
2012-07-01
... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.5 Procedures. (a) The Director of... for the FOIA/PA office is: National Security Agency, ATTN: FOIA/PA Services (DC321), 9800 Savage Road...
Code of Federal Regulations, 2014 CFR
2014-07-01
... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.5 Procedures. (a) The Director of... for the FOIA/PA office is: National Security Agency, ATTN: FOIA/PA Services (DC321), 9800 Savage Road...
Code of Federal Regulations, 2011 CFR
2011-07-01
... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.5 Procedures. (a) The Director of... for the FOIA/PA office is: National Security Agency, ATTN: FOIA/PA Services (DC321), 9800 Savage Road...
Code of Federal Regulations, 2013 CFR
2013-07-01
... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.5 Procedures. (a) The Director of... for the FOIA/PA office is: National Security Agency, ATTN: FOIA/PA Services (DC321), 9800 Savage Road...
20 CFR 322.7 - Dismissal, coordination, and separation allowances.
Code of Federal Regulations, 2010 CFR
2010-04-01
... UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.7 Dismissal, coordination, and separation allowances. (a... paid to the employee and found recoverable under section 2(f) of the Railroad Unemployment Insurance... Railroad Unemployment Insurance Act from receiving unemployment or sickness benefits for the period of time...
20 CFR 322.7 - Dismissal, coordination, and separation allowances.
Code of Federal Regulations, 2012 CFR
2012-04-01
... UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.7 Dismissal, coordination, and separation allowances. (a... paid to the employee and found recoverable under section 2(f) of the Railroad Unemployment Insurance... Railroad Unemployment Insurance Act from receiving unemployment or sickness benefits for the period of time...
20 CFR 322.7 - Dismissal, coordination, and separation allowances.
Code of Federal Regulations, 2011 CFR
2011-04-01
... UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.7 Dismissal, coordination, and separation allowances. (a... paid to the employee and found recoverable under section 2(f) of the Railroad Unemployment Insurance... Railroad Unemployment Insurance Act from receiving unemployment or sickness benefits for the period of time...
20 CFR 322.7 - Dismissal, coordination, and separation allowances.
Code of Federal Regulations, 2014 CFR
2014-04-01
... UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.7 Dismissal, coordination, and separation allowances. (a... paid to the employee and found recoverable under section 2(f) of the Railroad Unemployment Insurance... Railroad Unemployment Insurance Act from receiving unemployment or sickness benefits for the period of time...
20 CFR 322.7 - Dismissal, coordination, and separation allowances.
Code of Federal Regulations, 2013 CFR
2013-04-01
... UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.7 Dismissal, coordination, and separation allowances. (a... paid to the employee and found recoverable under section 2(f) of the Railroad Unemployment Insurance... Railroad Unemployment Insurance Act from receiving unemployment or sickness benefits for the period of time...
40 CFR 89.322 - Carbon dioxide analyzer calibration.
Code of Federal Regulations, 2010 CFR
2010-07-01
... Test Equipment Provisions § 89.322 Carbon dioxide analyzer calibration. (a) Prior to its introduction... requirements of paragraph (a)(3) of this section. Proceed as follows: (1) Follow good engineering practices for... engineering practice. For each range calibrated, if the deviation from a least-squares best-fit straight line...
75 FR 65382 - Agency Information Collection Activities: Proposed Collection; Comments Requested
Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-22
... of Information Collection Under Review: Implementation of Public Law 103-322, The Violent Crime... collection. (2) Title of the Form/Collection: Implementation of Public Law 103- 322, The Violent Crime...
75 FR 80847 - Agency Information Collection Activities: Proposed Collection; Comments Requested
Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-23
... of Information Collection Under Review: Implementation of Public Law 103-322, The Violent Crime... Form/Collection: Implementation of Public Law 103- 322, The Violent Crime Control and Law Enforcement...
Elevation of deck truss span over creek, looking NW along ...
Elevation of deck truss span over creek, looking NW along U.S. route 322. - Pennsylvania Railroad, Brandywine Valley Viaduct, Spanning Brandywine Creek & U.S. Route 322, Downingtown, Chester County, PA
Code of Federal Regulations, 2010 CFR
2010-07-01
... DEPARTMENT OF EDUCATION EMPLOYEES § 32.2 Definitions. The following definitions apply to this part: Department means the Department of Education. Disposable pay means the amount that remains from an employee's...; and such other deductions that are required by law to be withheld. Employee means a current or former...
Dai, Fuhong; Yoo, Won Gi; Lee, Ji-Yun; Lu, Yanyan; Pak, Jhang Ho; Sohn, Woon-Mok; Hong, Sung-Jong
2017-03-01
Multidrug resistance-associated protein 7 (MRP7, ABCC10) is a C subfamily member of the ATP-binding cassette (ABC) superfamily. MRP7 is a lipophilic anion transporter that pumps endogenous and xenobiotic substrates from the cytoplasm to the extracellular milieu. Here, we cloned and characterized CsMRP7 as a novel ABC transporter from the Chinese liver fluke, Clonorchis sinensis. Full-length cDNA of CsMRP7 was 5174 nt, encoded 1636 amino acids (aa), and harbored a 147-bp 5'-untranslated region (5'-UTR) and 116-bp 3'-UTR. Phylogenetic analysis confirmed that CsMRP7 was closer to the ABCC subfamily than the ABCB subfamily. Tertiary structures of the N-terminal region (1-322 aa) and core region (323-1621 aa) of CsMRP7 were generated by homology modeling using glucagon receptor (PDB ID: 5ee7_A) and P-glycoprotein (PDB ID: 4f4c_A) as templates, respectively. CsMRP7 nucleotide-binding domain 2 (NBD2) was conserved more than NBD1, which was the sites of ATP binding and hydrolysis. Like typical long MRPs, CsMRP7 has an additional membrane-spanning domain 0 (MSD0) and cytoplasmic loop, along with a common structural fold consisting of MSD1-NBD1-MSD2-NBD2 as a single polypeptide assembly. MSD0, MSD1, and MSD2 consisted of TM1-7, TM8-13, and TM14-19, respectively. The CsMRP7 transcript was more abundant in the metacercariae than in the adult worms. Truncated NBD1 (39 kDa) and NBD2 (44 kDa) were produced in bacteria and mouse immune sera were raised. CsMRP7 was localized in the apical side of the intestinal epithelium, sperm in the testes and seminal receptacle, receptacle membrane, and mesenchymal tissue around intestine in the adult worm. These results provide molecular information and insights into structural and functional characteristics of CsMRP7 and homologs of flukes.
Safety and immunogenicity of a quadrivalent intradermal influenza vaccine in adults.
Gorse, Geoffrey J; Falsey, Ann R; Ozol-Godfrey, Ayca; Landolfi, Victoria; Tsang, Peter H
2015-02-25
An intradermal (ID) trivalent split-virion influenza vaccine (IIV3-ID) (Fluzone(®) Intradermal, Sanofi Pasteur, Swiftwater, PA) has been available in the US since the 2011/2012 influenza season for adults aged 18-64 years. This study examined whether adding a second B-lineage strain affects immunogenicity and safety. This randomized, double-blind, multicentre trial evaluated the immunogenicity and safety of an intradermal quadrivalent split-virion influenza vaccine (IIV4-ID) in adults 18-64 years of age in the US during the 2012-2013 influenza season. Participants were randomized 2:1:1 to receive a single injection of IIV4-ID, licensed IIV3-ID, or an investigational IIV3-ID containing the alternate B-lineage strain. Haemagglutination inhibition antibody titres were assessed in two-thirds of participants before vaccination and 28 days after vaccination. 1672 participants were vaccinated with IIV4-ID, 837 with licensed IIV3-ID, and 846 with an investigational IIV3-ID. For all four vaccine strains, antibody responses to IIV4-ID were statistically non-inferior to the response to the IIV3-ID vaccines containing the matched strains. For both B strains, post-vaccination antibody responses to IIV4-ID were statistically superior to the responses to IIV3-ID lacking the corresponding B strain. Adverse events were similar for IIV4-ID and IIV3-ID. The most commonly reported solicited reactions were pain, pruritus, myalgia, headache, and malaise; and most were grade 1 or 2 and appeared and resolved within 3 days of vaccination. IIV4-ID was statistically non-inferior to the two pooled IIV3-ID vaccines for the proportions of participants with at least one grade 2 or 3 systemic reaction. Antibody responses to the IIV4-ID were non-inferior to IIV3-ID for the A and matched B strains and superior for the unmatched B strains. IIV4-ID was well tolerated without any safety concerns. IIV4-ID may help address an unmet need due to mismatched B strains in previous influenza vaccines. Copyright © 2015 Elsevier Ltd. All rights reserved.
Intelligent Design versus Evolution
Aviezer, Nathan
2010-01-01
Intelligent Design (ID) burst onto the scene in 1996, with the publication of Darwin’s Black Box by Michael Behe. Since then, there has been a plethora of articles written about ID, both pro and con. However, most of the articles critical of ID deal with peripheral issues, such as whether ID is just another form of creationism or whether ID qualifies as science or whether ID should be taught in public schools. It is our view that the central issue is whether the basic claim of ID is correct. Our goal is fourfold: (I) to show that most of the proposed refutations of ID are unconvincing and/or incorrect, (II) to describe the single fundamental error of ID, (III) to discuss the historic tradition surrounding the ID controversy, showing that ID is an example of a “god-of-the-gaps” argument, and (IV) to place the ID controversy in the larger context of proposed proofs for the existence of God, with the emphasis on Jewish tradition. PMID:23908779
Intelligent Design versus Evolution.
Aviezer, Nathan
2010-07-01
Intelligent Design (ID) burst onto the scene in 1996, with the publication of Darwin's Black Box by Michael Behe. Since then, there has been a plethora of articles written about ID, both pro and con. However, most of the articles critical of ID deal with peripheral issues, such as whether ID is just another form of creationism or whether ID qualifies as science or whether ID should be taught in public schools. It is our view that the central issue is whether the basic claim of ID is correct. Our goal is fourfold: (I) to show that most of the proposed refutations of ID are unconvincing and/or incorrect, (II) to describe the single fundamental error of ID, (III) to discuss the historic tradition surrounding the ID controversy, showing that ID is an example of a "god-of-the-gaps" argument, and (IV) to place the ID controversy in the larger context of proposed proofs for the existence of God, with the emphasis on Jewish tradition.
Desprez, Pierre-Yves; Campisi, Judith
2014-09-30
A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression.
322-R2U2 Engineering Assessment - August 2015
DOE Office of Scientific and Technical Information (OSTI.GOV)
Abri, M.; Griffin, D.
This Engineering Assessment and Certification of Integrity of retention tank system 322-R2 has been prepared for tank systems that store and neutralizes hazardous waste and have secondary containment. The regulations require that this assessment be completed periodically and certified by an independent, qualified, California-registered professional engineer. Abri Environmental Engineering performed an inspection of the 322-R2 Tank system at the Lawrence Livermore National Laboratory (LLNL) in Livermore, CA. Mr. William W. Moore, P.E., conducted this inspection on March 16, 2015. Mr. Moore is a California Registered Civil Engineer, with extensive experience in civil engineering, and hazardous waste management.
34 CFR 300.322 - Parent participation.
Code of Federal Regulations, 2012 CFR
2012-07-01
... Placements Individualized Education Programs § 300.322 Parent participation. (a) Public agency responsibility—general. Each public agency must take steps to ensure that one or both of the parents of a child with a... other than English. (f) Parent copy of child's IEP. The public agency must give the parent a copy of the...
34 CFR 300.322 - Parent participation.
Code of Federal Regulations, 2011 CFR
2011-07-01
... Placements Individualized Education Programs § 300.322 Parent participation. (a) Public agency responsibility—general. Each public agency must take steps to ensure that one or both of the parents of a child with a... other than English. (f) Parent copy of child's IEP. The public agency must give the parent a copy of the...
34 CFR 300.322 - Parent participation.
Code of Federal Regulations, 2014 CFR
2014-07-01
... Placements Individualized Education Programs § 300.322 Parent participation. (a) Public agency responsibility—general. Each public agency must take steps to ensure that one or both of the parents of a child with a... other than English. (f) Parent copy of child's IEP. The public agency must give the parent a copy of the...
34 CFR 300.322 - Parent participation.
Code of Federal Regulations, 2010 CFR
2010-07-01
... Placements Individualized Education Programs § 300.322 Parent participation. (a) Public agency responsibility—general. Each public agency must take steps to ensure that one or both of the parents of a child with a... other than English. (f) Parent copy of child's IEP. The public agency must give the parent a copy of the...
34 CFR 300.322 - Parent participation.
Code of Federal Regulations, 2013 CFR
2013-07-01
... Placements Individualized Education Programs § 300.322 Parent participation. (a) Public agency responsibility—general. Each public agency must take steps to ensure that one or both of the parents of a child with a... other than English. (f) Parent copy of child's IEP. The public agency must give the parent a copy of the...
2016-05-31
and included explosives such as TATP, HMTD, RDX, RDX, ammonium nitrate , potassium perchlorate, potassium nitrate , sugar, and TNT. The approach...Distribution Unlimited UU UU UU UU 31-05-2016 15-Apr-2014 14-Jan-2015 Final Report: Technical Topic 3.2.2. d Bayesian and Non- parametric Statistics...of Papers published in non peer-reviewed journals: Final Report: Technical Topic 3.2.2. d Bayesian and Non-parametric Statistics: Integration of Neural
Zhu, Lina; Luo, Xi; Tang, Qingjiu; Liu, Yanfang; Zhou, Shuai; Yang, Yan; Zhang, Jingsong
2013-01-01
To obtain a low-molecular-weight polysaccharide with immuno-enhancing activity, hot water extract of Ganoderma lucidum fruit bodies was separated by membrane ultrafiltration, anion exchange, and gel filtration chromatography, and the immunological activities of fractions were assessed on the basis of nitric oxide production by RAW 264.7 macrophages. A novel polysaccharide (TB3-2-2) was successfully isolated and purified. TB3-2-2 is a homogeneous polysaccharide, with a relative molecular weight of 5.11 × 103 Da, identified by high-performance liquid chromatography and was composed of galactose and glucose in a molar ratio of 2:3 determined by high-performance anion exchange chromatography. TB3-2-2 had a carbohydrate content of 99%, as measured using the phenol-sulfuric acid method. Proliferation of mouse spleen lymphocytes and the expression level of interleukin-6 was significantly increased by TB3-2-2. Results indicate that the low-molecular-weight polysaccharide with immunological activity in G. lucidum is worthy of further research and development.
The state of infectious diseases clinical trials: a systematic review of ClinicalTrials.gov.
Goswami, Neela D; Pfeiffer, Christopher D; Horton, John R; Chiswell, Karen; Tasneem, Asba; Tsalik, Ephraim L
2013-01-01
There is a paucity of clinical trials informing specific questions faced by infectious diseases (ID) specialists. The ClinicalTrials.gov registry offers an opportunity to evaluate the ID clinical trials portfolio. We examined 40,970 interventional trials registered with ClinicalTrials.gov from 2007-2010, focusing on study conditions and interventions to identify ID-related trials. Relevance to ID was manually confirmed for each programmatically identified trial, yielding 3570 ID trials and 37,400 non-ID trials for analysis. The number of ID trials was similar to the number of trials identified as belonging to cardiovascular medicine (n = 3437) or mental health (n = 3695) specialties. Slightly over half of ID trials were treatment-oriented trials (53%, vs. 77% for non-ID trials) followed by prevention (38%, vs. 8% in non-ID trials). ID trials tended to be larger than those of other specialties, with a median enrollment of 125 subjects (interquartile range [IQR], 45-400) vs. 60 (IQR, 30-160) for non-ID trials. Most ID studies are randomized (73%) but nonblinded (56%). Industry was the funding source in 51% of ID trials vs. 10% that were primarily NIH-funded. HIV-AIDS trials constitute the largest subset of ID trials (n = 815 [23%]), followed by influenza vaccine (n = 375 [11%]), and hepatitis C (n = 339 [9%]) trials. Relative to U.S. and global mortality rates, HIV-AIDS and hepatitis C virus trials are over-represented, whereas lower respiratory tract infection trials are under-represented in this large sample of ID clinical trials. This work is the first to characterize ID clinical trials registered in ClinicalTrials.gov, providing a framework to discuss prioritization, methodology, and policy.
32 CFR 644.322 - Disposition of proceeds from disposal.
Code of Federal Regulations, 2012 CFR
2012-07-01
... covered into the land and water conservation fund in the Treasury of the United States (16 U.S.C. 460L-5(a... water conservation fund as provided in paragraph (a) of this section. ... PROPERTY REAL ESTATE HANDBOOK Disposal § 644.322 Disposition of proceeds from disposal. (a) Land and Water...
32 CFR 644.322 - Disposition of proceeds from disposal.
Code of Federal Regulations, 2011 CFR
2011-07-01
... covered into the land and water conservation fund in the Treasury of the United States (16 U.S.C. 460L-5(a... water conservation fund as provided in paragraph (a) of this section. ... PROPERTY REAL ESTATE HANDBOOK Disposal § 644.322 Disposition of proceeds from disposal. (a) Land and Water...
32 CFR 644.322 - Disposition of proceeds from disposal.
Code of Federal Regulations, 2014 CFR
2014-07-01
... covered into the land and water conservation fund in the Treasury of the United States (16 U.S.C. 460L-5(a... water conservation fund as provided in paragraph (a) of this section. ... PROPERTY REAL ESTATE HANDBOOK Disposal § 644.322 Disposition of proceeds from disposal. (a) Land and Water...
32 CFR 644.322 - Disposition of proceeds from disposal.
Code of Federal Regulations, 2013 CFR
2013-07-01
... covered into the land and water conservation fund in the Treasury of the United States (16 U.S.C. 460L-5(a... water conservation fund as provided in paragraph (a) of this section. ... PROPERTY REAL ESTATE HANDBOOK Disposal § 644.322 Disposition of proceeds from disposal. (a) Land and Water...
32 CFR 644.322 - Disposition of proceeds from disposal.
Code of Federal Regulations, 2010 CFR
2010-07-01
... covered into the land and water conservation fund in the Treasury of the United States (16 U.S.C. 460L-5(a... water conservation fund as provided in paragraph (a) of this section. ... PROPERTY REAL ESTATE HANDBOOK Disposal § 644.322 Disposition of proceeds from disposal. (a) Land and Water...
7 CFR 322.7 - Notice of arrival.
Code of Federal Regulations, 2011 CFR
2011-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.7 Notice of arrival. (a) At least 10 business days prior to the arrival in the United States of any shipment of bees...
7 CFR 322.7 - Notice of arrival.
Code of Federal Regulations, 2014 CFR
2014-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.7 Notice of arrival. (a) At least 10 business days prior to the arrival in the United States of any shipment of bees...
7 CFR 322.7 - Notice of arrival.
Code of Federal Regulations, 2010 CFR
2010-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.7 Notice of arrival. (a) At least 10 business days prior to the arrival in the United States of any shipment of bees...
7 CFR 322.7 - Notice of arrival.
Code of Federal Regulations, 2013 CFR
2013-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.7 Notice of arrival. (a) At least 10 business days prior to the arrival in the United States of any shipment of bees...
7 CFR 322.7 - Notice of arrival.
Code of Federal Regulations, 2012 CFR
2012-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.7 Notice of arrival. (a) At least 10 business days prior to the arrival in the United States of any shipment of bees...
10 CFR 4.322 - Written notice, technical assistance, and educational materials.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 1 2010-01-01 2010-01-01 false Written notice, technical assistance, and educational... the Age Discrimination Act of 1975, as Amended Duties of Nrc Recipients § 4.322 Written notice, technical assistance, and educational materials. (a) NRC will provide written notice to each recipient of...
Active video games: the mediating effect of aerobic fitness on body composition.
Maddison, Ralph; Mhurchu, Cliona Ni; Jull, Andrew; Prapavessis, Harry; Foley, Louise S; Jiang, Yannan
2012-05-03
Increased understanding of why and how physical activity impacts on health outcomes is needed to increase the effectiveness of physical activity interventions. A recent randomized controlled trial of an active video game (PlayStation EyeToy™) intervention showed a statistically significant treatment effect on the primary outcome, change from baseline in body mass index (BMI), which favored the intervention group at 24 weeks. In this short paper we evaluate the mediating effects of the secondary outcomes. To identify mediators of the effect of an active video games intervention on body composition. Data from a two-arm parallel randomized controlled trial of an active video game intervention (n = 322) were analyzed. The primary outcome was change from baseline in BMI. A priori secondary outcomes were considered as potential mediators of the intervention on BMI, including aerobic fitness (VO2Max), time spent in moderate-to-vigorous physical activity (MVPA), and food snacking at 24 weeks. Only aerobic fitness at 24 weeks met the conditions for mediation, and was a significant mediator of BMI. Playing active video games can have a positive effect on body composition in overweight or obese children and this effect is most likely mediated through improved aerobic fitness. Future trials should examine other potential mediators related to this type of intervention. Australian New Zealand Clinical Trials Registry Website: http://www.anzctr.org.au. Study ID number: ACTRN12607000632493.
Cross-Cultural Register Differences in Infant-Directed Speech: An Initial Study.
Farran, Lama K; Lee, Chia-Cheng; Yoo, Hyunjoo; Oller, D Kimbrough
2016-01-01
Infant-directed speech (IDS) provides an environment that appears to play a significant role in the origins of language in the human infant. Differences have been reported in the use of IDS across cultures, suggesting different styles of infant language-learning. Importantly, both cross-cultural and intra-cultural research suggest there may be a positive relationship between the use of IDS and rates of language development, underscoring the need to investigate cultural differences more deeply. The majority of studies, however, have conceptualized IDS monolithically, granting little attention to a potentially key distinction in how IDS manifests across cultures during the first two years. This study examines and quantifies for the first time differences within IDS in the use of baby register (IDS/BR), an acoustically identifiable type of IDS that includes features such as high pitch, long duration, and smooth intonation (the register that is usually assumed to occur in IDS), and adult register (IDS/AR), the type of IDS that does not include such features and thus sounds as if it could have been addressed to an adult. We studied IDS across 19 American and 19 Lebanese mother-infant dyads, with particular focus on the differential use of registers within IDS as mothers interacted with their infants ages 0-24 months. Our results showed considerable usage of IDS/AR (>30% of utterances) and a tendency for Lebanese mothers to use more IDS than American mothers. Implications for future research on IDS and its role in elucidating how language evolves across cultures are explored.
Cross-Cultural Register Differences in Infant-Directed Speech: An Initial Study
Farran, Lama K.; Lee, Chia-Cheng; Yoo, Hyunjoo; Oller, D. Kimbrough
2016-01-01
Infant-directed speech (IDS) provides an environment that appears to play a significant role in the origins of language in the human infant. Differences have been reported in the use of IDS across cultures, suggesting different styles of infant language-learning. Importantly, both cross-cultural and intra-cultural research suggest there may be a positive relationship between the use of IDS and rates of language development, underscoring the need to investigate cultural differences more deeply. The majority of studies, however, have conceptualized IDS monolithically, granting little attention to a potentially key distinction in how IDS manifests across cultures during the first two years. This study examines and quantifies for the first time differences within IDS in the use of baby register (IDS/BR), an acoustically identifiable type of IDS that includes features such as high pitch, long duration, and smooth intonation (the register that is usually assumed to occur in IDS), and adult register (IDS/AR), the type of IDS that does not include such features and thus sounds as if it could have been addressed to an adult. We studied IDS across 19 American and 19 Lebanese mother-infant dyads, with particular focus on the differential use of registers within IDS as mothers interacted with their infants ages 0–24 months. Our results showed considerable usage of IDS/AR (>30% of utterances) and a tendency for Lebanese mothers to use more IDS than American mothers. Implications for future research on IDS and its role in elucidating how language evolves across cultures are explored. PMID:26981626
322. Dennis Hill, Photographer May 1998 VIEW OF GIRDER SPANS, ...
322. Dennis Hill, Photographer May 1998 VIEW OF GIRDER SPANS, OAKLAND APPROACH AT TRANSITION TO DOUBLE-DECK ROADWAY, FACING WEST. - San Francisco Oakland Bay Bridge, Spanning San Francisco Bay, San Francisco, San Francisco County, CA
Morton, Derrick; Sharma, Pankaj; Gorantla, Yamini; Joshi, Jugal; Nagappan, Perri; Pallaniappan, Ravi; Chaudhary, Jaideep
2016-01-01
ID4, a helix loop helix transcriptional regulator has emerged as a tumor suppressor in prostate cancer. Epigenetic silencing of ID4 promotes prostate cancer whereas ectopic expression in prostate cancer cell lines blocks cancer phenotype. To directly investigate the anti-tumor property, full length human recombinant ID4 encapsulated in biodegradable Polycaprolactone/Maltodextrin (PCL-MD) nano-carrier was delivered to LNCaP cells in which the native ID4 was stably silenced (LNCaP(-)ID4). The cellular uptake of ID4 resulted in increased apoptosis, decreased proliferation and colony formation. Intratumoral delivery of PCL-MD ID4 into growing LNCaP(-)ID4 tumors in SCID mice significantly reduced the tumor volume compared to the tumors treated with chemotherapeutic Docetaxel. The study supports the feasibility of using nano-carrier encapsulated ID4 protein as a therapeutic. Mechanistically, ID4 may assimilate multiple regulatory pathways for example epigenetic re-programming, integration of multiple AR co-regulators or signaling pathways resulting in tumor suppressor activity of ID4. PMID:27487149
The Self-Identity Protein IdsD Is Communicated between Cells in Swarming Proteus mirabilis Colonies.
Saak, Christina C; Gibbs, Karine A
2016-12-15
Proteus mirabilis is a social bacterium that is capable of self (kin) versus nonself recognition. Swarming colonies of this bacterium expand outward on surfaces to centimeter-scale distances due to the collective motility of individual cells. Colonies of genetically distinct populations remain separate, while those of identical populations merge. Ids proteins are essential for this recognition behavior. Two of these proteins, IdsD and IdsE, encode identity information for each strain. These two proteins bind in vitro in an allele-restrictive manner. IdsD-IdsE binding is correlated with the merging of populations, whereas a lack of binding is correlated with the separation of populations. Key questions remained about the in vivo interactions of IdsD and IdsE, specifically, whether IdsD and IdsE bind within single cells or whether IdsD-IdsE interactions occur across neighboring cells and, if so, which of the two proteins is exchanged. Here we demonstrate that IdsD must originate from another cell to communicate identity and that this nonresident IdsD interacts with IdsE resident in the recipient cell. Furthermore, we show that unbound IdsD in recipient cells does not cause cell death and instead appears to contribute to a restriction in the expansion radius of the swarming colony. We conclude that P. mirabilis communicates IdsD between neighboring cells for nonlethal kin recognition, which suggests that the Ids proteins constitute a type of cell-cell communication. We demonstrate that self (kin) versus nonself recognition in P. mirabilis entails the cell-cell communication of an identity-encoding protein that is exported from one cell and received by another. We further show that this intercellular exchange affects swarm colony expansion in a nonlethal manner, which adds social communication to the list of potential swarm-related regulatory factors. Copyright © 2016, American Society for Microbiology. All Rights Reserved.
The Self-Identity Protein IdsD Is Communicated between Cells in Swarming Proteus mirabilis Colonies
Saak, Christina C.
2016-01-01
ABSTRACT Proteus mirabilis is a social bacterium that is capable of self (kin) versus nonself recognition. Swarming colonies of this bacterium expand outward on surfaces to centimeter-scale distances due to the collective motility of individual cells. Colonies of genetically distinct populations remain separate, while those of identical populations merge. Ids proteins are essential for this recognition behavior. Two of these proteins, IdsD and IdsE, encode identity information for each strain. These two proteins bind in vitro in an allele-restrictive manner. IdsD-IdsE binding is correlated with the merging of populations, whereas a lack of binding is correlated with the separation of populations. Key questions remained about the in vivo interactions of IdsD and IdsE, specifically, whether IdsD and IdsE bind within single cells or whether IdsD-IdsE interactions occur across neighboring cells and, if so, which of the two proteins is exchanged. Here we demonstrate that IdsD must originate from another cell to communicate identity and that this nonresident IdsD interacts with IdsE resident in the recipient cell. Furthermore, we show that unbound IdsD in recipient cells does not cause cell death and instead appears to contribute to a restriction in the expansion radius of the swarming colony. We conclude that P. mirabilis communicates IdsD between neighboring cells for nonlethal kin recognition, which suggests that the Ids proteins constitute a type of cell-cell communication. IMPORTANCE We demonstrate that self (kin) versus nonself recognition in P. mirabilis entails the cell-cell communication of an identity-encoding protein that is exported from one cell and received by another. We further show that this intercellular exchange affects swarm colony expansion in a nonlethal manner, which adds social communication to the list of potential swarm-related regulatory factors. PMID:27672195
46 CFR 197.322 - Surface-supplied helmets and masks.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Surface-supplied helmets and masks. 197.322 Section 197... helmets and masks. (a) Each surface-supplied helmet or mask must have— (1) A nonreturn valve at the attachment point between helmet or mask and umbilical that closes readily and positively; (2) An exhaust...
Swift monitoring observations of 1H 1743-322 and its evolution towards a state transition
NASA Astrophysics Data System (ADS)
Yan, Zhen; Lin, Jie; Yu, Wenfei; Zhang, Wenda; Zhang, Hui; Mao, Dongming
2016-03-01
Following the report of the new outburst of black hole X-ray binary H1743-322 (ATel #8751), we requested a series of Swift ToO observations to monitor the X-ray temporal and spectral evolution and potential jet contribution to the UV flux during the outburst.
Code of Federal Regulations, 2012 CFR
2012-10-01
... older, who possesses a license. One adult hunter may supervise no more than two youth hunters. 9. You may possess only approved nontoxic shot while hunting with a shotgun (see § 32.2(k)). 10. We prohibit... nontoxic shot while hunting turkey (see § 32.2(k)). 4. Hunters may possess lead-rifled slugs while deer...
Code of Federal Regulations, 2014 CFR
2014-10-01
... older, who possesses a license. One adult hunter may supervise no more than two youth hunters. 9. You may possess only approved nontoxic shot while hunting with a shotgun (see § 32.2(k)). 10. We prohibit... nontoxic shot while hunting turkey (see § 32.2(k)). 4. Hunters may possess lead-rifled slugs while deer...
Code of Federal Regulations, 2013 CFR
2013-10-01
... older, who possesses a license. One adult hunter may supervise no more than two youth hunters. 9. You may possess only approved nontoxic shot while hunting with a shotgun (see § 32.2(k)). 10. We prohibit... nontoxic shot while hunting turkey (see § 32.2(k)). 4. Hunters may possess lead-rifled slugs while deer...
Microbe-ID: an open source toolbox for microbial genotyping and species identification.
Tabima, Javier F; Everhart, Sydney E; Larsen, Meredith M; Weisberg, Alexandra J; Kamvar, Zhian N; Tancos, Matthew A; Smart, Christine D; Chang, Jeff H; Grünwald, Niklaus J
2016-01-01
Development of tools to identify species, genotypes, or novel strains of invasive organisms is critical for monitoring emergence and implementing rapid response measures. Molecular markers, although critical to identifying species or genotypes, require bioinformatic tools for analysis. However, user-friendly analytical tools for fast identification are not readily available. To address this need, we created a web-based set of applications called Microbe-ID that allow for customizing a toolbox for rapid species identification and strain genotyping using any genetic markers of choice. Two components of Microbe-ID, named Sequence-ID and Genotype-ID, implement species and genotype identification, respectively. Sequence-ID allows identification of species by using BLAST to query sequences for any locus of interest against a custom reference sequence database. Genotype-ID allows placement of an unknown multilocus marker in either a minimum spanning network or dendrogram with bootstrap support from a user-created reference database. Microbe-ID can be used for identification of any organism based on nucleotide sequences or any molecular marker type and several examples are provided. We created a public website for demonstration purposes called Microbe-ID (microbe-id.org) and provided a working implementation for the genus Phytophthora (phytophthora-id.org). In Phytophthora-ID, the Sequence-ID application allows identification based on ITS or cox spacer sequences. Genotype-ID groups individuals into clonal lineages based on simple sequence repeat (SSR) markers for the two invasive plant pathogen species P. infestans and P. ramorum. All code is open source and available on github and CRAN. Instructions for installation and use are provided at https://github.com/grunwaldlab/Microbe-ID.
Id-1 promotes osteosarcoma cell growth and inhibits cell apoptosis via PI3K/AKT signaling pathway
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hao, Liang; Liao, Qi; Tang, Qiang
2016-02-12
Accumulating evidence reveals that Id-1 is upregulated and functions as a potential tumor promoter in several human cancer types. However, the role of Id-1 in osteosarcoma (OS) is unknown. In present study, we found that Id-1 expression was elevated in OS tissues than adjacent normal bone tissues. More importantly, we demonstrated that overexpression of Id-1 is significantly correlated with tumor progression and poor survival in OS patients. Furthermore, increased expression of Id-1 was observed in OS cell lines and ectopic expression of Id-1 significantly enhanced in vitro cell proliferation and promoted in vivo tumor growth, whereas knockdown of Id-1 suppressed OS cellsmore » growth. Moreover, our experimental data revealed that Id-1 promotes cell proliferation by facilitating cell cycle progression and inhibits cell apoptosis. Mechanistically, the effects of Id-1 in OS cells is at least partly through activation of PI3K/Akt signaling pathway. Therefore, we identified a tumorigenic role of Id-1 in OS and suggested a potential therapeutic target for OS patients. - Highlights: • Id-1 expression is positively correlated in OS patients with poor prognosis. • Overexpression of Id-1 promotes OS cell growth in vitro and in vivo. • Id-1induces cell cycle progression and inhibits cell apoptosis. • PI3K/Akt signaling pathway contributed to the oncogenic effects of Id-1 in OS cells.« less
Neumeister, Alexander; Drevets, Wayne C; Belfer, Inna; Luckenbaugh, David A; Henry, Shannan; Bonne, Omer; Herscovitch, Peter; Goldman, David; Charney, Dennis S
2006-08-01
Alterations in processing of emotionally salient information have been reported in individuals with major depressive disorder (MDD). Evidence suggests a role for noradrenaline in the regulation of a cortico-limbic-striatal circuit that has also been implicated in the pathophysiology of MDD. Herein, we studied the physiological consequences of a common coding polymorphism of the gene for the alpha(2C)-adrenoreceptor (AR) subtype--the deletion of four consecutive amino acids at codons 322-325 of the alpha2C-AR (alpha2CDel322-325-AR) in medication-free, remitted individuals with MDD (rMDD), and healthy control subjects. After injection of 10 mCi of H2(15)O, positron emission tomography (PET) measures of neural activity were acquired while subjects were viewing unmasked sad, happy, and fearful faces. The neural responses to sad facial expressions were increased in the amygdala and decreased in the left ventral striatum in rMDD patients relative to healthy control subjects. Furthermore, we report that rMDD carriers of one or two copies of the alpha2CDel322-325-AR exhibit greater amygdala as well as pregenual and subgenual anterior cingulate gyrus neuronal activity in response to sad faces than healthy alpha2CDel322-325-AR carriers and rMDD noncarriers. These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD.
NASA Astrophysics Data System (ADS)
Ud Din, Zia; Serrano, N. F. G.; Ademi, Kastriot; Sousa, C. P.; Deflon, Victor Marcelo; Maia, Pedro Ivo da Silva; Rodrigues-Filho, Edson
2017-09-01
In this work the screening of 20 unsymmetrical chalcone and curcuminoids analogues in regard of their antimicrobial properties was conducted. Electron donating groups in the aromatic rings in the chalcone and curcuminoid derivatives produced higher antimicrobial effect. Compounds 1, 9 and 15 exhibited good activity against Escherichia coli and Staphylococcus aureus. These compounds were further evaluated against nine micro-organisms of pathological interest. Pharmmaper was used for target fishing of compounds against important bacterial targets. Molecular Docking helped to verify the results of these compounds against the selected bacterial target D-alanyl-D-alanine carboxypeptidase (PDB ID: 1PW1). The crystal structure of ligand and docked conformers in the active site of 1PW1 were analyzed. As a result structure-activity relationships are proposed. Structures of compounds 14 and 16 were obtained through single crystals X-ray diffraction studies. Compound 14 crystallizes in monoclinic space group P21/c with unit cell dimensions a = 13.1293(3) Å, b = 17.5364(4) Å, c = 15.1433(3) Å, β = 95.6440(10), V = 3469.70(13) Å3 and Z = 8. Compound 16 crystallizes in triclinic space group Pī with unit cell dimensions a = 6.8226(4) Å, b = 7.2256(4) Å, c = 18.1235(12) Å, β = 87.322(4), V = 850.57(9) Å3 and Z = 2.
Fan, Shu-Quan; Huang, Wei; Wang, Lai-Xi
2012-01-01
Endo-β-N-acetylglucosaminidase from Streptococcus pneumoniae (Endo-D) is an endoglycosidase capable of hydrolyzing the Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-D also possesses transglycosylation activity with sugar oxazoline as the donor substrate, but the transglycosylation yield is low due to enzymatic hydrolysis of the donor substrate and the product. We report here our study on the hydrolytic and transglycosylation activity of recombinant Endo-D and its selected mutants. We found that Endo-D preferred core-fucosylated N-glycan for hydrolysis but favored nonfucosylated GlcNAc acceptor for transglycosylation. Several mutants showed significantly enhanced transglycosylation efficiency over the wild type enzyme. Two mutants (N322Q and N322A) were identified as typical glycosynthases that demonstrated remarkable transglycosylation activity with only marginal or no product hydrolysis activity. Kinetic studies revealed that the N332Q and N322A glycosynthases had much higher catalytic efficiency for glycosylating the nonfucosylated GlcNAc acceptor. In comparison, the N322Q was much more efficient than N322A for transglycosylation. However, N332Q and N332A could not take more complex N-glycan oxazoline as substrate for transglycosylation, indicating their strict substrate specificity. The usefulness of the N332Q glycosynthase was exemplified by its application for efficient glycosylation remodeling of IgG-Fc domain. PMID:22318728
Castañón, Eduardo; Soltermann, Alex; López, Inés; Román, Marta; Ecay, Margarita; Collantes, María; Redrado, Miriam; Baraibar, Iosune; López-Picazo, José María; Rolfo, Christian; Vidal-Vanaclocha, Fernando; Raez, Luis; Weder, Walter; Calvo, Alfonso; Gil-Bazo, Ignacio
2017-08-28
Id1 promotes carcinogenesis and metastasis, and predicts prognosis of non-small cell lung cancer (NSCLC)-adenocarcionoma patients. We hypothesized that Id1 may play a critical role in lung cancer colonization of the liver by affecting both tumor cells and the microenvironment. Depleted levels of Id1 in LLC (Lewis lung carcinoma cells, LLC shId1) significantly reduced cell proliferation and migration in vitro. Genetic loss of Id1 in the host tissue (Id1 -/- mice) impaired liver colonization and increased survival of Id1 -/- animals. Histologically, the presence of Id1 in tumor cells of liver metastasis was responsible for liver colonization. Microarray analysis comparing liver tumor nodules from Id1 +/+ mice and Id1 -/- mice injected with LLC control cells revealed that Id1 loss reduces the levels of EMT-related proteins, such as vimentin. In tissue microarrays containing 532 NSCLC patients' samples, we found that Id1 significantly correlated with vimentin and other EMT-related proteins. Id1 loss decreased the levels of vimentin, integrinβ1, TGFβ1 and snail, both in vitro and in vivo. Therefore, Id1 enables both LLC and the host microenvironment for an effective liver colonization, and may represent a novel therapeutic target to avoid NSCLC liver metastasis. Copyright © 2017 Elsevier B.V. All rights reserved.
Swift/BAT X-ray monitoring indicates a new outburst of the black hole transient H 1743-322
NASA Astrophysics Data System (ADS)
Zhang, Hui; Yu, Wenfei; Yan, Zhen; Lin, Jie
2017-07-01
H 1743-322 is a black hole X-ray binary with frequent outbursts. Recent Swift/BAT monitoring observations (Krimm et al. 2013) show that this source has turned into a new outburst after been in quiescence for about nine months since the most recent outburst in 2016.
Microbe-ID: an open source toolbox for microbial genotyping and species identification
Tabima, Javier F.; Everhart, Sydney E.; Larsen, Meredith M.; Weisberg, Alexandra J.; Kamvar, Zhian N.; Tancos, Matthew A.; Smart, Christine D.; Chang, Jeff H.
2016-01-01
Development of tools to identify species, genotypes, or novel strains of invasive organisms is critical for monitoring emergence and implementing rapid response measures. Molecular markers, although critical to identifying species or genotypes, require bioinformatic tools for analysis. However, user-friendly analytical tools for fast identification are not readily available. To address this need, we created a web-based set of applications called Microbe-ID that allow for customizing a toolbox for rapid species identification and strain genotyping using any genetic markers of choice. Two components of Microbe-ID, named Sequence-ID and Genotype-ID, implement species and genotype identification, respectively. Sequence-ID allows identification of species by using BLAST to query sequences for any locus of interest against a custom reference sequence database. Genotype-ID allows placement of an unknown multilocus marker in either a minimum spanning network or dendrogram with bootstrap support from a user-created reference database. Microbe-ID can be used for identification of any organism based on nucleotide sequences or any molecular marker type and several examples are provided. We created a public website for demonstration purposes called Microbe-ID (microbe-id.org) and provided a working implementation for the genus Phytophthora (phytophthora-id.org). In Phytophthora-ID, the Sequence-ID application allows identification based on ITS or cox spacer sequences. Genotype-ID groups individuals into clonal lineages based on simple sequence repeat (SSR) markers for the two invasive plant pathogen species P. infestans and P. ramorum. All code is open source and available on github and CRAN. Instructions for installation and use are provided at https://github.com/grunwaldlab/Microbe-ID. PMID:27602267
50 CFR 648.322 - Skate allocation, possession, and landing provisions.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Skate allocation, possession, and landing... Management Measures for the NE Skate Complex Fisheries § 648.322 Skate allocation, possession, and landing... TAL not landed in Seasons 1 or 2 shall be allocated. (b) Skate wing possession and landing limits. A...
50 CFR 648.322 - Skate allocation, possession, and landing provisions.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Skate allocation, possession, and landing... Management Measures for the NE Skate Complex Fisheries § 648.322 Skate allocation, possession, and landing... TAL not landed in Seasons 1 or 2 shall be allocated. (b) Skate wing possession and landing limits. A...
21 CFR 173.322 - Chemicals used in delinting cottonseed.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Chemicals used in delinting cottonseed. 173.322... Limitations alpha-Alkyl-omega-hydroxypoly-(oxyethylene) produced by condensation of a linear primary alcohol... units May be used at an application rate not to exceed 0.3 percent by weight of cottonseeds to enhance...
Code of Federal Regulations, 2012 CFR
2012-10-01
... possess only approved nontoxic shot while in the field (see § 32.2(k)). 3. We allow only portable blinds... a one-piece filler incapable of removal without disassembling the gun, so its total capacity does... boundaries to hunting. 3. You may only possess approved nontoxic shot while in the field (see § 32.2(k)). 4...
Code of Federal Regulations, 2014 CFR
2014-10-01
... possess only approved nontoxic shot while in the field (see § 32.2(k)). 3. We allow only portable blinds... a one-piece filler incapable of removal without disassembling the gun, so its total capacity does... boundaries to hunting. 3. You may only possess approved nontoxic shot while in the field (see § 32.2(k)). 4...
Code of Federal Regulations, 2013 CFR
2013-10-01
... possess only approved nontoxic shot while in the field (see § 32.2(k)). 3. We allow only portable blinds... a one-piece filler incapable of removal without disassembling the gun, so its total capacity does... boundaries to hunting. 3. You may only possess approved nontoxic shot while in the field (see § 32.2(k)). 4...
ERIC Educational Resources Information Center
Lee, Jihyun; Jang, Seonyoung
2014-01-01
Instructional design (ID) models have been developed to promote understandings of ID reality and guide ID performance. As the number and diversity of ID practices grows, implicit doubts regarding the reliability, validity, and usefulness of ID models suggest the need for methodological guidance that would help to generate ID models that are…
NASA Astrophysics Data System (ADS)
Kamei, Masayuki; Takao, Yoshinori; Eriguchi, Koji; Ono, Kouichi
2014-01-01
We clarified in this study how plasma-induced charging damage (PCD) affects the so-called “random telegraph noise (RTN)” — a principal concern in designing ultimately scaled large-scale integrated circuits (LSIs). Metal-oxide-semiconductor field-effect transistors (MOSFETs) with SiO2 and high-k gate dielectric were exposed to an inductively coupled plasma (ICP) with Ar gas. Drain current vs gate voltage (Ids-Vg) characteristics were obtained before and after the ICP plasma exposure for the same device. Then, the time evolution of Ids fluctuation defined as Ids/μIds was measured, where μIds is the mean Ids. This value corresponds to an RTN feature, and RTN was obtained under various gate voltages (Vg) by a customized measurement technique. We focused on the statistical distribution width of (Ids/μIds), δ(Ids/μIds), in order to clarify the effects of PCD on RTN. δ(Ids/μIds) was increased by PCD for both MOSFETs with the SiO2 and high-k gate dielectrics, suggesting that RTN can be used as a measure of PCD, i.e., a distribution width increase directly indicates the presence of PCD. The dependence of δ(Ids/μIds) on the overdrive voltage Vg-Vth, where Vth is the threshold voltage, was investigated by the present technique. It was confirmed that δ(Ids/μIds) increased with a decrease in the overdrive voltage for MOSFETs with the SiO2 and high-k gate dielectrics. The presence of created carrier trap sites with PCD was characterized by the time constants for carrier capture and emission. The threshold voltage shift (ΔVth) induced by PCD was also evaluated and compared with the RTN change, to correlate the RTN increase with ΔVth induced by PCD. Although the estimated time constants exhibited complex behaviors due to the nature of trap sites created by PCD, δ(Ids/μIds) showed a straightforward tendency in accordance with the amount of PCD. These findings provide an in-depth understanding of plasma-induced RTN characteristic changes in future MOSFETs.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-10
... of the US40-322 (Albany Avenue) Bridge, at NJICW mile 70.0, across Inside Thoroughfare, in Atlantic... the 2012 Atlantic City Triathlon. The US40-322 (Albany Avenue) Bridge, at NJICW mile 70.0 across...
Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-02
... $589,322 limit that corresponds to the outstanding amount of the original performance bond issued by...,322 limit) in accordance with instructions to be provided by EPA, in the event that EPA takes over...
Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-30
... Commission to waive the requirement that approximately 322.24 acres of airport property, located at the... request by the Laurinburg-Maxton Airport Commission to release approximately 322.24 acres of airport...
History of Allied Force Headquarters - Part Three, December 1943 - July 1944. Section 1
1945-11-01
AG NATOUSA Itr, 322 /287 A»0, 22 Dec 43 (AG AAF/MTO files 322 ). AAF/MTO GO No 1, 1 Jaa 44. 87. AAF/MTO GO No 4, 15 Jan 44; No 12, 7 Mar 44; aad No 31...February 1944 between Major General FoGo Beaumont-Nesbitt, British Chief Liaison Officer MEF, and General Ranosovio s Chief of Staff Jugo slav Forces Hq...in occupied ITALY were brought under one central authorityp ACC 0 67. FAN Cable No 2805 CCS to Eisenhower p 26 Nov 43. 68. Memo MOS 322 -17 on Crg of
43 CFR 17.322 - Assurance of compliance and recipient assessment of age distinctions.
Code of Federal Regulations, 2010 CFR
2010-10-01
... Nondiscrimination on the Basis of Age Duties of Doi Recipients § 17.322 Assurance of compliance and recipient assessment of age distinctions. (a) Each recipient of Federal financial assistance from DOI shall sign a written assurance as specified by DOI that it will comply with the Act and these regulations. (b...
Code of Federal Regulations, 2014 CFR
2014-10-01
... nontoxic shot are the legal means that may be used or possessed during these hunts (see § 32.2(k)). 5. We... nontoxic shot for hunting while in the field (see § 32.2(k)). 5. Refuge permits (name only) are required... allowed. 14. A hunter may bring one guest. Guest may not use a hunting firearm or other hunting weapon...
43 CFR 17.322 - Assurance of compliance and recipient assessment of age distinctions.
Code of Federal Regulations, 2011 CFR
2011-10-01
... Nondiscrimination on the Basis of Age Duties of Doi Recipients § 17.322 Assurance of compliance and recipient assessment of age distinctions. (a) Each recipient of Federal financial assistance from DOI shall sign a written assurance as specified by DOI that it will comply with the Act and these regulations. (b...
Training on intellectual disability in health sciences: the European perspective.
Salvador-Carulla, Luis; Martínez-Leal, Rafael; Heyler, Carla; Alvarez-Galvez, Javier; Veenstra, Marja Y; García-Ibáñez, Jose; Carpenter, Sylvia; Bertelli, Marco; Munir, Kerim; Torr, Jennifer; Van Schrojenstein Lantman-de Valk, Henny M J
2015-01-01
Intellectual disability (ID) has consequences at all stages of life, requires high service provision and leads to high health and societal costs. However, ID is largely disregarded as a health issue by national and international organisations, as are training in ID and in the health aspects of ID at every level of the education system. This paper aims to (1) update the current information about availability of training and education in ID and related health issues in Europe with a particular focus in mental health; and (2) to identify opportunities arising from the initial process of educational harmonization in Europe to include ID contents in health sciences curricula and professional training. We carried out a systematic search of scientific databases and websites, as well as policy and research reports from the European Commission, European Council and WHO. Furthermore, we contacted key international organisations related to health education and/or ID in Europe, as well as other regional institutions. ID modules and contents are minimal in the revised health sciences curricula and publications on ID training in Europe are equally scarce. European countries report few undergraduate and graduate training modules in ID, even in key specialties such as paediatrics. Within the health sector, ID programmes focus mainly on psychiatry and psychology. The poor availability of ID training in health sciences is a matter of concern. However, the current European policy on training provides an opportunity to promote ID in the curricula of programmes at all levels. This strategy should address all professionals working in ID and it should increase the focus on ID relative to other developmental disorders at all stages of life.
Participation in daytime activities among people with mild or moderate intellectual disability.
Dusseljee, J C E; Rijken, P M; Cardol, M; Curfs, L M G; Groenewegen, P P
2011-01-01
Community participation has been defined as performing daytime activities by people while interacting with others. Previous studies on community participation among people with intellectual disability (ID) have mainly focused on the domestic life aspect. This study investigates the variation in community participation in the domains work, social contacts and leisure activities among people with ID in the Netherlands. A number of categories of people with ID were distinguished by: (1) gender; (2) age; (3) type of education; (4) severity of ID; and (5) accommodation type. Data were gathered on 653 people with mild or moderate ID, of whom 513 by oral interviews and 140 by structured questionnaires filled in by representatives of those who could not be interviewed. Pearson chi-square tests were used to test differences between categories of people with ID in the distributions of the participation variables. Additional logistic regression analyses were conducted to correct for differences between the categories in other variables. Most people with mild or moderate ID in the Netherlands have work or other daytime activities, have social contacts and have leisure activities. However, people aged 50 years and over and people with moderate ID participate less in these domains than those under 50 years and people with mild ID. Moreover, people with ID hardly participate in activities with people without ID. High participation among people with a mild or moderate ID within the domains of work, social contact and leisure activities does not necessarily indicate a high level of interaction with the community, because the majority hardly interact with people without ID. Furthermore, older people with ID and people with a more severe level of ID seem to be more at risk for social exclusion. © 2010 The Authors. Journal of Intellectual Disability Research © 2010 Blackwell Publishing Ltd.
Training on intellectual disability in health sciences: the European perspective
Salvador-Carulla, Luis; Martínez-Leal, Rafael; Heyler, Carla; Alvarez-Galvez, Javier; Veenstra, Marja Y.; García-Ibáñez, Jose; Carpenter, Sylvia; Bertelli, Marco; Munir, Kerim; Torr, Jennifer; Van Schrojenstein Lantman-de Valk, Henny M. J.
2015-01-01
Background Intellectual disability (ID) has consequences at all stages of life, requires high service provision and leads to high health and societal costs. However, ID is largely disregarded as a health issue by national and international organisations, as are training in ID and in the health aspects of ID at every level of the education system. Specific aim This paper aims to (1) update the current information about availability of training and education in ID and related health issues in Europe with a particular focus in mental health; and (2) to identify opportunities arising from the initial process of educational harmonization in Europe to include ID contents in health sciences curricula and professional training. Method We carried out a systematic search of scientific databases and websites, as well as policy and research reports from the European Commission, European Council and WHO. Furthermore, we contacted key international organisations related to health education and/or ID in Europe, as well as other regional institutions. Results ID modules and contents are minimal in the revised health sciences curricula and publications on ID training in Europe are equally scarce. European countries report few undergraduate and graduate training modules in ID, even in key specialties such as paediatrics. Within the health sector, ID programmes focus mainly on psychiatry and psychology. Conclusion The poor availability of ID training in health sciences is a matter of concern. However, the current European policy on training provides an opportunity to promote ID in the curricula of programmes at all levels. This strategy should address all professionals working in ID and it should increase the focus on ID relative to other developmental disorders at all stages of life. PMID:25705375
Chen, B; Han, B H; Sun, X H; Lim, R W
1997-01-15
We have examined the role of an Id-like protein, Id3 (also known as HLH462), in the regulation of muscle-specific gene expression. Id proteins are believed to block expression of muscle-specific genes by preventing the dimerization between ubiquitous bHLH proteins (E proteins) and myogenic bHLH proteins such as MyoD. Consistent with its putative role as an inhibitor of differentiation, Id3 mRNA was detected in proliferating skeletal muscle cells, was further induced by basic fibroblast growth factor (bFGF) and was down-regulated in differentiated muscle cultures. Overexpression of Id3 efficiently inhibited the MyoD-mediated activation of the muscle-specific creatine kinase (MCK) reporter gene. Deletion analysis indicated that the C-terminal 15 amino acids of Id3 are critical for the full inhibitory activity while deleting up to 42 residues from the C-terminus of the related protein, Id2, did not affect its ability to inhibit the MCK reporter gene. Chimeric protein containing the N-terminal region of Id3 and the C-terminus of Id2 was also non-functional in transfected cells. In contrast, wild-type Id3, the C-terminal mutants, and the Id3/Id2 chimera could all interact with the E-protein E47in vitro. Additional studies indicated that truncation of the Id3 C-terminus might have adversely affected the expression level of the mutant proteins but the Id3/Id2 chimera was stably expressed. Taken together, our results revealed a more complex requirement for the expression and proper function of the Id family proteins than was hitherto expected.
Chen, B; Han, B H; Sun, X H; Lim, R W
1997-01-01
We have examined the role of an Id-like protein, Id3 (also known as HLH462), in the regulation of muscle-specific gene expression. Id proteins are believed to block expression of muscle-specific genes by preventing the dimerization between ubiquitous bHLH proteins (E proteins) and myogenic bHLH proteins such as MyoD. Consistent with its putative role as an inhibitor of differentiation, Id3 mRNA was detected in proliferating skeletal muscle cells, was further induced by basic fibroblast growth factor (bFGF) and was down-regulated in differentiated muscle cultures. Overexpression of Id3 efficiently inhibited the MyoD-mediated activation of the muscle-specific creatine kinase (MCK) reporter gene. Deletion analysis indicated that the C-terminal 15 amino acids of Id3 are critical for the full inhibitory activity while deleting up to 42 residues from the C-terminus of the related protein, Id2, did not affect its ability to inhibit the MCK reporter gene. Chimeric protein containing the N-terminal region of Id3 and the C-terminus of Id2 was also non-functional in transfected cells. In contrast, wild-type Id3, the C-terminal mutants, and the Id3/Id2 chimera could all interact with the E-protein E47in vitro. Additional studies indicated that truncation of the Id3 C-terminus might have adversely affected the expression level of the mutant proteins but the Id3/Id2 chimera was stably expressed. Taken together, our results revealed a more complex requirement for the expression and proper function of the Id family proteins than was hitherto expected. PMID:9016574
5 CFR 530.322 - Setting pay when a special rate schedule is newly established or increased.
Code of Federal Regulations, 2010 CFR
2010-01-01
... Recruitment and Retention Setting An Employee's Rate of Pay § 530.322 Setting pay when a special rate schedule is newly established or increased. (a) General rule. When an employee holds a position that becomes... agency must set the employee's special rate at the step (or relative position in range for a GM employee...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-24
... the US40-322 (Albany Avenue) Bridge, at NJICW mile 70.0, across Inside Thorofare in Atlantic City, NJ.... The US40-322 (Albany Avenue) Bridge, at NJICW mile 70.0 across Inside Thorofare in Atlantic City, NJ...
7 CFR 322.6 - Export certificate.
Code of Federal Regulations, 2013 CFR
2013-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.6 Export certificate. Each shipment of bees and honeybee germ plasm arriving in the United States from an approved...
7 CFR 322.4 - Approved regions.
Code of Federal Regulations, 2011 CFR
2011-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.4 Approved regions..., Bermuda, Canada, France, Great Britain, New Zealand, and Sweden. (c) Bees other than honeybees. The...
7 CFR 322.6 - Export certificate.
Code of Federal Regulations, 2011 CFR
2011-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.6 Export certificate. Each shipment of bees and honeybee germ plasm arriving in the United States from an approved...
7 CFR 322.6 - Export certificate.
Code of Federal Regulations, 2014 CFR
2014-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.6 Export certificate. Each shipment of bees and honeybee germ plasm arriving in the United States from an approved...
7 CFR 322.4 - Approved regions.
Code of Federal Regulations, 2014 CFR
2014-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.4 Approved regions..., Bermuda, Canada, France, Great Britain, New Zealand, and Sweden. (c) Bees other than honeybees. The...
7 CFR 322.4 - Approved regions.
Code of Federal Regulations, 2013 CFR
2013-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.4 Approved regions..., Bermuda, Canada, France, Great Britain, New Zealand, and Sweden. (c) Bees other than honeybees. The...
7 CFR 322.6 - Export certificate.
Code of Federal Regulations, 2012 CFR
2012-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.6 Export certificate. Each shipment of bees and honeybee germ plasm arriving in the United States from an approved...
7 CFR 322.4 - Approved regions.
Code of Federal Regulations, 2012 CFR
2012-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.4 Approved regions..., Bermuda, Canada, France, Great Britain, New Zealand, and Sweden. (c) Bees other than honeybees. The...
7 CFR 322.4 - Approved regions.
Code of Federal Regulations, 2010 CFR
2010-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.4 Approved regions..., Bermuda, Canada, France, Great Britain, New Zealand, and Sweden. (c) Bees other than honeybees. The...
33 CFR 322.5 - Special policies.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 322.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF... Special policies. The Secretary of the Army has delegated to the Chief of Engineers the authority to issue...), the district engineer will review the applicant's provisions for siting, constructing, monitoring...
33 CFR 322.5 - Special policies.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 322.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF... Special policies. The Secretary of the Army has delegated to the Chief of Engineers the authority to issue...), the district engineer will review the applicant's provisions for siting, constructing, monitoring...
33 CFR 322.5 - Special policies.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 322.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF... Special policies. The Secretary of the Army has delegated to the Chief of Engineers the authority to issue...), the district engineer will review the applicant's provisions for siting, constructing, monitoring...
32 CFR 322.1 - Purpose and applicability.
Code of Federal Regulations, 2012 CFR
2012-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.1 Purpose and... of Defense Privacy Program (32 CFR part 310) within the National Security Agency/Central Security...
32 CFR 322.1 - Purpose and applicability.
Code of Federal Regulations, 2014 CFR
2014-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.1 Purpose and... of Defense Privacy Program (32 CFR part 310) within the National Security Agency/Central Security...
32 CFR 322.1 - Purpose and applicability.
Code of Federal Regulations, 2011 CFR
2011-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.1 Purpose and... of Defense Privacy Program (32 CFR part 310) within the National Security Agency/Central Security...
32 CFR 322.1 - Purpose and applicability.
Code of Federal Regulations, 2010 CFR
2010-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.1 Purpose and... of Defense Privacy Program (32 CFR part 310) within the National Security Agency/Central Security...
32 CFR 322.1 - Purpose and applicability.
Code of Federal Regulations, 2013 CFR
2013-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.1 Purpose and... of Defense Privacy Program (32 CFR part 310) within the National Security Agency/Central Security...
7 CFR 1207.322 - Nominations and appointment.
Code of Federal Regulations, 2013 CFR
2013-01-01
... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.322... of potato producers. Such nomination meetings shall be held not later than 60 days after the issuance...
7 CFR 1207.322 - Nominations and appointment.
Code of Federal Regulations, 2012 CFR
2012-01-01
... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.322... of potato producers. Such nomination meetings shall be held not later than 60 days after the issuance...
7 CFR 1207.322 - Nominations and appointment.
Code of Federal Regulations, 2014 CFR
2014-01-01
... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.322... of potato producers. Such nomination meetings shall be held not later than 60 days after the issuance...
18 CFR 32.2 - Required exhibits.
Code of Federal Regulations, 2010 CFR
2010-04-01
... facilities used for the generation and transmission of electric energy, indicating on said map the points... Section 32.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTERCONNECTION OF FACILITIES Application for An Order...
18 CFR 32.2 - Required exhibits.
Code of Federal Regulations, 2011 CFR
2011-04-01
... facilities used for the generation and transmission of electric energy, indicating on said map the points... Section 32.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTERCONNECTION OF FACILITIES Application for An Order...
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zhang, Long; Shi, Songting; Zhang, Juan
Highlights: Black-Right-Pointing-Pointer Expression of Id3 but not Id1 is induced by Wnt3a stimulation in C2C12 cells. Black-Right-Pointing-Pointer Wnt3a induces Id3 expression via canonical Wnt/{beta}-catenin pathway. Black-Right-Pointing-Pointer Wnt3a-induced Id3 expression does not depend on BMP signaling activation. Black-Right-Pointing-Pointer Induction of Id3 expression is critical determinant in Wnt3a-induced cell proliferation and differentiation. -- Abstract: Canonical Wnt signaling plays important roles in regulating cell proliferation and differentiation. In this study, we report that inhibitor of differentiation (Id)3 is a Wnt-inducible gene in mouse C2C12 myoblasts. Wnt3a induced Id3 expression in a {beta}-catenin-dependent manner. Bone morphogenetic protein (BMP) also potently induced Id3 expression. However,more » Wnt-induced Id3 expression occurred independent of the BMP/Smad pathway. Functional studies showed that Id3 depletion in C2C12 cells impaired Wnt3a-induced cell proliferation and alkaline phosphatase activity, an early marker of osteoblast cells. Id3 depletion elevated myogenin induction during myogenic differentiation and partially impaired Wnt3a suppressed myogenin expression in C2C12 cells. These results suggest that Id3 is an important Wnt/{beta}-catenin induced gene in myoblast cell fate determination.« less
Sun, Lili; Li, Xuenong; Liu, Guobing
2013-06-01
To investigate the expression of inhibitor of DNA differentiation/DNA binding 1 (Id1) and Id3 in endometrial carcinoma and explore their roles in regulating the proliferation, invasion, migration and adhesion of endometrial carcinoma cells in vitro. Id1 and Id3 expression in 4 fresh endometrial cancer tissue specimens and matched adjacent tissues were detected using Western blotting. Two endometrial cancer cell lines, HEC-1-B and RL-952, were both divided into 4 groups, namely the untreated group, blank virus group, promoter group and Id1/Id3 double-knockdown group, and their expressions of MMP2, CXCR4 and P21 were detected by qRT-PCR and Western blotting. The proliferation, invasion, migration and adhesion of the cells were evaluated with MTT, Transwell, wound-healing, and adhesion assays. Endometrial carcinoma tissues showed significantly higher Id1 and Id3 expression than the adjacent tissues (P<0.05). In the two endometrial carcinoma cell lines, Id1/Id3 double-knockdown significantly decreased MMP2 and CXCR4 expression and increased P21 expression at both mRNA and protein levels (P<0.05), and resulted in suppressed cell proliferation, invasion, migration and adhesion. Id1 and Id3 expressions are up-regulated in endometrial carcinoma to promote the proliferation, invasion, migration and adhesion of the tumor cells by increasing MMP2 and CXCR4 expression and reducing P21 expression. Therapies targeting Id1/Id3 can be a novel strategy for treatment of endometrial carcinoma.
Observation of Electron Neutrino Appearance in a Muon Neutrino Beam
NASA Astrophysics Data System (ADS)
Abe, K.; Adam, J.; Aihara, H.; Akiri, T.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Ariga, T.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bass, M.; Batkiewicz, M.; Bay, F.; Bentham, S. W.; Berardi, V.; Berger, B. E.; Berkman, S.; Bertram, I.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S. R.; Densham, C.; Di Lodovico, F.; Di Luise, S.; Drapier, O.; Duboyski, T.; Duffy, K.; Dufour, F.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Emery, S.; Ereditato, A.; Escudero, L.; Finch, A. J.; Floetotto, L.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Gaudin, A.; Giffin, S.; Giganti, C.; Gilje, K.; Goeldi, D.; Golan, T.; Gomez-Cadenas, J. J.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Ives, S. J.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Johnson, R. A.; Jo, J. H.; Jonsson, P.; Jung, C. K.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Koch, L.; Kolaceke, A.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kreslo, I.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kumaratunga, S.; Kurjata, R.; Kutter, T.; Lagoda, J.; Laihem, K.; Lamont, I.; Laveder, M.; Lawe, M.; Lazos, M.; Lee, K. P.; Licciardi, C.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Ludovici, L.; Macaire, M.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marino, A. D.; Marteau, J.; Martin, J. F.; Maruyama, T.; Marzec, J.; Mathie, E. L.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Mine, S.; Missert, A.; Miura, M.; Monfregola, L.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nagasaki, T.; Nakadaira, T.; Nakahata, M.; Nakai, T.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Naples, D.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Owen, R. A.; Oyama, Y.; Palladino, V.; Paolone, V.; Payne, D.; Pearce, G. F.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pickard, L. J.; Pinzon Guerra, E. S.; Pistillo, C.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Redij, A.; Reeves, M.; Reinherz-Aronis, E.; Retiere, F.; Robert, A.; Rodrigues, P. A.; Rojas, P.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smith, R. J.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suda, Y.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Szeglowski, T.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. K.; Tanaka, H. A.; Tanaka, M. M.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Ueno, K.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yen, S.; Yershov, N.; Yokoyama, M.; Yuan, T.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.; T2K Collaboration
2014-02-01
The T2K experiment has observed electron neutrino appearance in a muon neutrino beam produced 295 km from the Super-Kamiokande detector with a peak energy of 0.6 GeV. A total of 28 electron neutrino events were detected with an energy distribution consistent with an appearance signal, corresponding to a significance of 7.3σ when compared to 4.92±0.55 expected background events. In the Pontecorvo-Maki-Nakagawa-Sakata mixing model, the electron neutrino appearance signal depends on several parameters including three mixing angles θ12, θ23, θ13, a mass difference Δm322 and a CP violating phase δCP. In this neutrino oscillation scenario, assuming |Δm322|=2.4×10-3 eV2, sin2θ23=0.5, and Δm322>0 (Δm322<0), a best-fit value of sin22θ13=0.140-0.032+0.038 (0.170-0.037+0.045) is obtained at δCP=0. When combining the result with the current best knowledge of oscillation parameters including the world average value of θ13 from reactor experiments, some values of δCP are disfavored at the 90% C.L.
Role of ID Proteins in BMP4 Inhibition of Profibrotic Effects of TGF-β2 in Human TM Cells.
Mody, Avani A; Wordinger, Robert J; Clark, Abbot F
2017-02-01
Increased expression of TGF-β2 in primary open-angle glaucoma (POAG) aqueous humor (AH) and trabecular meshwork (TM) causes deposition of extracellular matrix (ECM) in the TM and elevated IOP. Bone morphogenetic proteins (BMPs) regulate TGF-β2-induced ECM production. The underlying mechanism for BMP4 inhibition of TGF-β2-induced fibrosis remains undetermined. Bone morphogenic protein 4 induces inhibitor of DNA binding proteins (ID1, ID3), which suppress transcription factor activities to regulate gene expression. Our study will determine whether ID1and ID3 proteins are downstream targets of BMP4, which attenuates TGF-β2 induction of ECM proteins in TM cells. Primary human TM cells were treated with BMP4, and ID1 and ID3 mRNA, and protein expression was determined by quantitative PCR (Q-PCR) and Western immunoblotting. Intracellular ID1 and ID3 protein localization was studied by immunocytochemistry. Transformed human TM cells (GTM3 cells) were transfected with ID1 or ID3 expression vectors to determine their potential inhibitory effects on TGF-β2-induced fibronectin and plasminogen activator inhibitor-I (PAI-1) protein expression. Basal expression of ID1-3 was detected in primary human TM cells. Bone morphogenic protein 4 significantly induced early expression of ID1 and ID3 mRNA (P < 0.05) and protein in primary TM cells, and a BMP receptor inhibitor blocked this induction. Overexpression of ID1 and ID3 significantly inhibited TGF-β2-induced expression of fibronectin and PAI-1 in TM cells (P < 0.01). Bone morphogenic protein 4 induced ID1 and ID3 expression suppresses TGF-β2 profibrotic activity in human TM cells. In the future, targeting specific regulators may control the TGF-β2 profibrotic effects on the TM, leading to disease modifying IOP lowering therapies.
Chen, Ching-Jen; Moosa, Shayan; Ding, Dale; Raper, Daniel M; Burke, Rebecca M; Lee, Cheng-Chia; Chivukula, Srinivas; Wang, Tony R; Starke, Robert M; Crowley, R Webster; Liu, Kenneth C
2016-08-01
Cerebrovascular infundibular dilations (IDs) are triangular-shaped widenings less than 3 mm in diameter, which are most commonly found at the posterior communicating artery (PCoA). The aims of this systematic review are to elucidate the natural histories of IDs, determine their risk of progression to significant pathology, and discuss potential management options. A comprehensive literature search of PubMed was used to find all case reports and series relating to cerebral IDs. IDs were classified into three types: type I IDs do not exhibit morphological change over a long follow-up period, type II IDs evolve into saccular aneurysms, while type III IDs are those that result in subarachnoid hemorrhage without prior aneurysmal progression. Data were extracted from studies that demonstrated type II or III IDs. We reviewed 16 cases of type II and seven cases of type III IDs. For type II IDs, 81.3% of patients were female with a median age at diagnosis of 38. All type II IDs were located at the PCoA without a clear predilection for sidedness. Median time to aneurysm progression was 7.5 years. For type III IDs there was no clear gender preponderance and the median age at diagnosis was 51. The PCoA was involved in 85.7% of cases, with 57.1% of IDs occurring on the left. Most patients were treated with clipping. Risk factors for aneurysm formation appear to be female gender, young age, left-sided localization, coexisting aneurysms, and hypertension. IDs can rarely progress to aneurysms or rupture. Young patients with type II or III IDs with coexisting aneurysms or hypertension may benefit from long-term imaging surveillance. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Code of Federal Regulations, 2014 CFR
2014-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.1... Plant Health Inspection Service of the United States Department of Agriculture. Bee. Any member of the..., including, but not limited to, beeswax for beekeeping, pollen for bee feed, or honey for bee feed...
7 CFR 322.11 - Ports of entry.
Code of Federal Regulations, 2011 CFR
2011-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.11 Ports of entry. Shipments of honeybees, honeybee germ plasm, and bees other than honeybees imported under this subpart may...
7 CFR 322.11 - Ports of entry.
Code of Federal Regulations, 2013 CFR
2013-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.11 Ports of entry. Shipments of honeybees, honeybee germ plasm, and bees other than honeybees imported under this subpart may...
7 CFR 322.11 - Ports of entry.
Code of Federal Regulations, 2012 CFR
2012-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.11 Ports of entry. Shipments of honeybees, honeybee germ plasm, and bees other than honeybees imported under this subpart may...
Code of Federal Regulations, 2010 CFR
2010-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.1... Plant Health Inspection Service of the United States Department of Agriculture. Bee. Any member of the..., including, but not limited to, beeswax for beekeeping, pollen for bee feed, or honey for bee feed...
Code of Federal Regulations, 2011 CFR
2011-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.1... Plant Health Inspection Service of the United States Department of Agriculture. Bee. Any member of the..., including, but not limited to, beeswax for beekeeping, pollen for bee feed, or honey for bee feed...
7 CFR 322.11 - Ports of entry.
Code of Federal Regulations, 2010 CFR
2010-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.11 Ports of entry. Shipments of honeybees, honeybee germ plasm, and bees other than honeybees imported under this subpart may...
Code of Federal Regulations, 2012 CFR
2012-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.1... Plant Health Inspection Service of the United States Department of Agriculture. Bee. Any member of the..., including, but not limited to, beeswax for beekeeping, pollen for bee feed, or honey for bee feed...
Code of Federal Regulations, 2013 CFR
2013-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.1... Plant Health Inspection Service of the United States Department of Agriculture. Bee. Any member of the..., including, but not limited to, beeswax for beekeeping, pollen for bee feed, or honey for bee feed...
7 CFR 322.11 - Ports of entry.
Code of Federal Regulations, 2014 CFR
2014-01-01
..., DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.11 Ports of entry. Shipments of honeybees, honeybee germ plasm, and bees other than honeybees imported under this subpart may...
32 CFR 322.6 - Establishing exemptions.
Code of Federal Regulations, 2011 CFR
2011-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.6 Establishing... the National Security Agency shall be prohibited to the extent authorized by Pub. L. No. 86-36 (1959...
32 CFR 322.6 - Establishing exemptions.
Code of Federal Regulations, 2012 CFR
2012-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.6 Establishing... the National Security Agency shall be prohibited to the extent authorized by Pub. L. No. 86-36 (1959...
32 CFR 322.6 - Establishing exemptions.
Code of Federal Regulations, 2013 CFR
2013-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.6 Establishing... the National Security Agency shall be prohibited to the extent authorized by Pub. L. No. 86-36 (1959...
32 CFR 322.6 - Establishing exemptions.
Code of Federal Regulations, 2014 CFR
2014-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.6 Establishing... the National Security Agency shall be prohibited to the extent authorized by Pub. L. No. 86-36 (1959...
32 CFR 322.6 - Establishing exemptions.
Code of Federal Regulations, 2010 CFR
2010-07-01
... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.6 Establishing... the National Security Agency shall be prohibited to the extent authorized by Pub. L. No. 86-36 (1959...
Qualitative Data Analysis for Health Services Research: Developing Taxonomy, Themes, and Theory
Bradley, Elizabeth H; Curry, Leslie A; Devers, Kelly J
2007-01-01
Objective To provide practical strategies for conducting and evaluating analyses of qualitative data applicable for health services researchers. Data Sources and Design We draw on extant qualitative methodological literature to describe practical approaches to qualitative data analysis. Approaches to data analysis vary by discipline and analytic tradition; however, we focus on qualitative data analysis that has as a goal the generation of taxonomy, themes, and theory germane to health services research. Principle Findings We describe an approach to qualitative data analysis that applies the principles of inductive reasoning while also employing predetermined code types to guide data analysis and interpretation. These code types (conceptual, relationship, perspective, participant characteristics, and setting codes) define a structure that is appropriate for generation of taxonomy, themes, and theory. Conceptual codes and subcodes facilitate the development of taxonomies. Relationship and perspective codes facilitate the development of themes and theory. Intersectional analyses with data coded for participant characteristics and setting codes can facilitate comparative analyses. Conclusions Qualitative inquiry can improve the description and explanation of complex, real-world phenomena pertinent to health services research. Greater understanding of the processes of qualitative data analysis can be helpful for health services researchers as they use these methods themselves or collaborate with qualitative researchers from a wide range of disciplines. PMID:17286625
Qualitative data analysis for health services research: developing taxonomy, themes, and theory.
Bradley, Elizabeth H; Curry, Leslie A; Devers, Kelly J
2007-08-01
To provide practical strategies for conducting and evaluating analyses of qualitative data applicable for health services researchers. DATA SOURCES AND DESIGN: We draw on extant qualitative methodological literature to describe practical approaches to qualitative data analysis. Approaches to data analysis vary by discipline and analytic tradition; however, we focus on qualitative data analysis that has as a goal the generation of taxonomy, themes, and theory germane to health services research. We describe an approach to qualitative data analysis that applies the principles of inductive reasoning while also employing predetermined code types to guide data analysis and interpretation. These code types (conceptual, relationship, perspective, participant characteristics, and setting codes) define a structure that is appropriate for generation of taxonomy, themes, and theory. Conceptual codes and subcodes facilitate the development of taxonomies. Relationship and perspective codes facilitate the development of themes and theory. Intersectional analyses with data coded for participant characteristics and setting codes can facilitate comparative analyses. Qualitative inquiry can improve the description and explanation of complex, real-world phenomena pertinent to health services research. Greater understanding of the processes of qualitative data analysis can be helpful for health services researchers as they use these methods themselves or collaborate with qualitative researchers from a wide range of disciplines.
Finning, Kirstin; Bhandari, Radhika; Sellers, Fiona; Revelli, Nicoletta; Villa, Maria Antonietta; Muñiz-Díaz, Eduardo; Nogués, Núria
2016-03-01
High-throughput genotyping platforms enable simultaneous analysis of multiple polymorphisms for blood group typing. BLOODchip® ID is a genotyping platform based on Luminex® xMAP technology for simultaneous determination of 37 red blood cell (RBC) antigens (ID CORE XT) and 18 human platelet antigens (HPA) (ID HPA XT) using the BIDS XT software. In this international multicentre study, the performance of ID CORE XT and ID HPA XT, using the centres' current genotyping methods as the reference for comparison, and the usability and practicality of these systems, were evaluated under working laboratory conditions. DNA was extracted from whole blood in EDTA with Qiagen methodologies. Ninety-six previously phenotyped/genotyped samples were processed per assay: 87 testing samples plus five positive controls and four negative controls. Results were available for 519 samples: 258 with ID CORE XT and 261 with ID HPA XT. There were three "no calls" that were either caused by human error or resolved after repeating the test. Agreement between the tests and reference methods was 99.94% for ID CORE XT (9,540/9,546 antigens determined) and 100% for ID HPA XT (all 4,698 alleles determined). There were six discrepancies in antigen results in five RBC samples, four of which (in VS, N, S and Do(a)) could not be investigated due to lack of sufficient sample to perform additional tests and two of which (in S and C) were resolved in favour of ID CORE XT (100% accuracy). The total hands-on time was 28-41 minutes for a batch of 16 samples. Compared with the reference platforms, ID CORE XT and ID HPA XT were considered simpler to use and had shorter processing times. ID CORE XT and ID HPA XT genotyping platforms for RBC and platelet systems were accurate and user-friendly in working laboratory settings.
29 CFR 779.322 - Second requirement for qualifying as a “retail or service establishment.”
Code of Federal Regulations, 2013 CFR
2013-07-01
... FAIR LABOR STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments ârecognizedâ As Retail âin the Particular Industryâ § 779.322 Second requirement for qualifying as a “retail or service establishment.” If the business is one to which the retail...
29 CFR 779.322 - Second requirement for qualifying as a “retail or service establishment.”
Code of Federal Regulations, 2011 CFR
2011-07-01
... FAIR LABOR STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments ârecognizedâ As Retail âin the Particular Industryâ § 779.322 Second requirement for qualifying as a “retail or service establishment.” If the business is one to which the retail...
29 CFR 779.322 - Second requirement for qualifying as a “retail or service establishment.”
Code of Federal Regulations, 2012 CFR
2012-07-01
... FAIR LABOR STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments ârecognizedâ As Retail âin the Particular Industryâ § 779.322 Second requirement for qualifying as a “retail or service establishment.” If the business is one to which the retail...
29 CFR 779.322 - Second requirement for qualifying as a “retail or service establishment.”
Code of Federal Regulations, 2014 CFR
2014-07-01
... FAIR LABOR STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments ârecognizedâ As Retail âin the Particular Industryâ § 779.322 Second requirement for qualifying as a “retail or service establishment.” If the business is one to which the retail...
Code of Federal Regulations, 2013 CFR
2013-10-01
..., A8, and A9 apply. 8. Hunters may place no more than one stand on the refuge. Stands may not be in... approved nontoxic shot while in the field (see § 32.2(k)). B. Upland Game Hunting. We allow hunting of... approved nontoxic shot while in the field (see § 32.2(k)). 5. You may hunt beaver during any established...
Code of Federal Regulations, 2012 CFR
2012-10-01
..., A8, and A9 apply. 8. Hunters may place no more than one stand on the refuge. Stands may not be in... approved nontoxic shot while in the field (see § 32.2(k)). B. Upland Game Hunting. We allow hunting of... approved nontoxic shot while in the field (see § 32.2(k)). 5. You may hunt beaver during any established...
Code of Federal Regulations, 2014 CFR
2014-10-01
..., A8, and A9 apply. 8. Hunters may place no more than one stand on the refuge. Stands may not be in... approved nontoxic shot while in the field (see § 32.2(k)). B. Upland Game Hunting. We allow hunting of... approved nontoxic shot while in the field (see § 32.2(k)). 5. You may hunt beaver during any established...
ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells
DOE Office of Scientific and Technical Information (OSTI.GOV)
Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H.; Morton, Derrick J.
Deregulation of tumor suppressor genes is associated with tumorigenesis and the development of cancer. In prostate cancer, ID4 is epigenetically silenced and acts as a tumor suppressor. In normal prostate epithelial cells, ID4 collaborates with androgen receptor (AR) and p53 to exert its tumor suppressor activity. Previous studies have shown that ID4 promotes tumor suppressive function of AR whereas loss of ID4 results in tumor promoter activity of AR. Previous study from our lab showed that ectopic ID4 expression in DU145 attenuates proliferation and promotes AR expression suggesting that ID4 dependent AR activity is tumor suppressive. In this study, wemore » examined the effect of ectopic expression of ID4 on highly malignant prostate cancer cell, PC3. Here we show that stable overexpression of ID4 in PC3 cells leads to increased apoptosis and decreased cell proliferation and migration. In addition, in vivo studies showed a decrease in tumor size and volume of ID4 overexpressing PC3 cells, in nude mice. At the molecular level, these changes were associated with increased androgen receptor (AR), p21, and AR dependent FKBP51 expression. At the mechanistic level, ID4 may regulate the expression or function of AR through specific but yet unknown AR co-regulators that may determine the final outcome of AR function. - Highlights: • ID4 expression induces AR expression in PC3 cells, which generally lack AR. • ID4 expression increased apoptosis and decreased cell proliferation and invasion. • Overexpression of ID4 reduces tumor growth of subcutaneous xenografts in vivo. • ID4 induces p21 and FKBP51 expression- co-factors of AR tumor suppressor activity.« less
Detecting 'infant-directedness' in face and voice.
Kim, Hojin I; Johnson, Scott P
2014-07-01
Five- and 3-month-old infants' perception of infant-directed (ID) faces and the role of speech in perceiving faces were examined. Infants' eye movements were recorded as they viewed a series of two side-by-side talking faces, one infant-directed and one adult-directed (AD), while listening to ID speech, AD speech, or in silence. Infants showed consistently greater dwell time on ID faces vs. AD faces, and this ID face preference was consistent across all three sound conditions. ID speech resulted in higher looking overall, but it did not increase looking at the ID face per se. Together, these findings demonstrate that infants' preferences for ID speech extend to ID faces. © 2014 John Wiley & Sons Ltd.
Reduction in pediatric identification band errors: a quality collaborative.
Phillips, Shannon Connor; Saysana, Michele; Worley, Sarah; Hain, Paul D
2012-06-01
Accurate and consistent placement of a patient identification (ID) band is used in health care to reduce errors associated with patient misidentification. Multiple safety organizations have devoted time and energy to improving patient ID, but no multicenter improvement collaboratives have shown scalability of previously successful interventions. We hoped to reduce by half the pediatric patient ID band error rate, defined as absent, illegible, or inaccurate ID band, across a quality improvement learning collaborative of hospitals in 1 year. On the basis of a previously successful single-site intervention, we conducted a self-selected 6-site collaborative to reduce ID band errors in heterogeneous pediatric hospital settings. The collaborative had 3 phases: preparatory work and employee survey of current practice and barriers, data collection (ID band failure rate), and intervention driven by data and collaborative learning to accelerate change. The collaborative audited 11377 patients for ID band errors between September 2009 and September 2010. The ID band failure rate decreased from 17% to 4.1% (77% relative reduction). Interventions including education of frontline staff regarding correct ID bands as a safety strategy; a change to softer ID bands, including "luggage tag" type ID bands for some patients; and partnering with families and patients through education were applied at all institutions. Over 13 months, a collaborative of pediatric institutions significantly reduced the ID band failure rate. This quality improvement learning collaborative demonstrates that safety improvements tested in a single institution can be disseminated to improve quality of care across large populations of children.
Gleitz, Hélène Fe; Liao, Ai Yin; Cook, James R; Rowlston, Samuel F; Forte, Gabriella Ma; D'Souza, Zelpha; O'Leary, Claire; Holley, Rebecca J; Bigger, Brian W
2018-06-08
The pediatric lysosomal storage disorder mucopolysaccharidosis type II is caused by mutations in IDS, resulting in accumulation of heparan and dermatan sulfate, causing severe neurodegeneration, skeletal disease, and cardiorespiratory disease. Most patients manifest with cognitive symptoms, which cannot be treated with enzyme replacement therapy, as native IDS does not cross the blood-brain barrier. We tested a brain-targeted hematopoietic stem cell gene therapy approach using lentiviral IDS fused to ApoEII (IDS.ApoEII) compared to a lentivirus expressing normal IDS or a normal bone marrow transplant. In mucopolysaccharidosis II mice, all treatments corrected peripheral disease, but only IDS.ApoEII mediated complete normalization of brain pathology and behavior, providing significantly enhanced correction compared to IDS. A normal bone marrow transplant achieved no brain correction. Whilst corrected macrophages traffic to the brain, secreting IDS/IDS.ApoEII enzyme for cross-correction, IDS.ApoEII was additionally more active in plasma and was taken up and transcytosed across brain endothelia significantly better than IDS via both heparan sulfate/ApoE-dependent receptors and mannose-6-phosphate receptors. Brain-targeted hematopoietic stem cell gene therapy provides a promising therapy for MPS II patients. © 2018 The Authors. Published under the terms of the CC BY 4.0 license.
[Infectious diseases in the adult population admitted to a general hospital].
Ramos, José M; Pinargote, Héctor; Torrús, Diego; Sánchez-Martínez, Rosario; Merino, Esperanza; Portilla, Joaquín
2015-10-01
To determine the infectious diseases (ID) that led to hospital admission of the foreign population>14 years. A retrospective study of foreign patients admitted to hospital (2000-2012). A total of 3,087 foreigners were admitted with infectious diseases. Of these, 73.6% were from low income countries, and 26.4% from high income countries. Most of them (86.9%) were admitted with common ID, 11.8% with transmissible ID, and 1.6% with tropical ID. Tropical ID and transmissible ID were higher in patients from low income countries (14.7%) than from high income countries (9.7%, p<0.001). The main tropical ID was malaria (74%). The main transmissible ID were tuberculosis (40.3%), hepatitis (27.8%), and HIV/AIDS (27.5%). Common ID were the main reason for admission in foreign population. Copyright © 2014 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.
33 CFR 322.3 - Activities requiring permits.
Code of Federal Regulations, 2012 CFR
2012-07-01
....3 Section 322.3 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PERMITS FOR STRUCTURES OR WORK IN OR AFFECTING NAVIGABLE WATERS OF THE UNITED STATES... history and/or provisions of the Act should clearly demonstrate that Congress was approving the exact...
7 CFR 322.8 - Packaging of shipments.
Code of Federal Regulations, 2013 CFR
2013-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.8... States under this subpart: (1) Must be packaged to prevent the escape of any bees or bee pests; (2) Must...
7 CFR 322.8 - Packaging of shipments.
Code of Federal Regulations, 2014 CFR
2014-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.8... States under this subpart: (1) Must be packaged to prevent the escape of any bees or bee pests; (2) Must...
7 CFR 322.8 - Packaging of shipments.
Code of Federal Regulations, 2012 CFR
2012-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.8... States under this subpart: (1) Must be packaged to prevent the escape of any bees or bee pests; (2) Must...
7 CFR 322.8 - Packaging of shipments.
Code of Federal Regulations, 2011 CFR
2011-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.8... States under this subpart: (1) Must be packaged to prevent the escape of any bees or bee pests; (2) Must...
7 CFR 322.8 - Packaging of shipments.
Code of Federal Regulations, 2010 CFR
2010-01-01
... SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult Honeybees, Honeybee Germ Plasm, and Bees Other Than Honeybees From Approved Regions § 322.8... States under this subpart: (1) Must be packaged to prevent the escape of any bees or bee pests; (2) Must...
9 CFR 93.322 - Declaration for horses.
Code of Federal Regulations, 2010 CFR
2010-01-01
... CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Horses Mexico 18 § 93.322 Declaration for horses. For all horses offered for importation from Mexico, the importer or his or her agent shall present two...
New metrics for evaluating channel networks extracted in grid digital elevation models
NASA Astrophysics Data System (ADS)
Orlandini, S.; Moretti, G.
2017-12-01
Channel networks are critical components of drainage basins and delta regions. Despite the important role played by these systems in hydrology and geomorphology, there are at present no well-defined methods to evaluate numerically how two complex channel networks are geometrically far apart. The present study introduces new metrics for evaluating numerically channel networks extracted in grid digital elevation models with respect to a reference channel network (see the figure below). Streams of the evaluated network (EN) are delineated as in the Horton ordering system and examined through a priority climbing algorithm based on the triple index (ID1,ID2,ID3), where ID1 is a stream identifier that increases as the elevation of lower end of the stream increases, ID2 indicates the ID1 of the draining stream, and ID3 is the ID1 of the corresponding stream in the reference network (RN). Streams of the RN are identified by the double index (ID1,ID2). Streams of the EN are processed in the order of increasing ID1 (plots a-l in the figure below). For each processed stream of the EN, the closest stream of the RN is sought by considering all the streams of the RN sharing the same ID2. This ID2 in the RN is equal in the EN to the ID3 of the stream draining the processed stream, the one having ID1 equal to the ID2 of the processed stream. The mean stream planar distance (MSPD) and the mean stream elevation drop (MSED) are computed as the mean distance and drop, respectively, between corresponding streams. The MSPD is shown to be useful for evaluating slope direction methods and thresholds for channel initiation, whereas the MSED is shown to indicate the ability of grid coarsening strategies to retain the profiles of observed channels. The developed metrics fill a gap in the existing literature by allowing hydrologists and geomorphologists to compare descriptions of a fixed physical system obtained by using different terrain analysis methods, or different physical systems described by using the same methods.
75 FR 44030 - Agency Forms Submitted for OMB Review, Request for Comments
Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-27
..., ID-4X, Advising of Service/Earnings Requirements for Sickness Benefits, ID-20-1, Advising that Normal..., ID-4K, ID-4Y, ID-20-1, ID-20-2, and ID-204 is required to obtain or retain benefits. One response is... determine (1) the practical utility of the collection; (2) the accuracy of the estimated burden of the...
Stankic, Marko; Pavlovic, Svetlana; Chin, Yvette; Brogi, Edi; Padua, David; Norton, Larry; Massague, Joan; Benezra, Robert
2014-01-01
SUMMARY ID genes are required for breast cancer colonization of the lungs, but the mechanism remains poorly understood. Here, we show that Id1 expression induces a stem-like phenotype in breast cancer cells, while retaining epithelial properties, contrary to the notion that cancer stem-like properties are inextricably linked to the mesenchymal state. During metastatic colonization, Id1 induces a mesenchymal-to-epithelial transition (MET), specifically in cells whose mesenchymal state is dependent on the Id1 target protein Twist1 but not at the primary site, where this state is controlled by the zinc-finger protein Snail1. Knockdown of Id expression in metastasizing cells prevents MET and dramatically reduces lung colonization. Furthermore, Id1 is induced by TGFβ only in cells that have first undergone EMT, demonstrating that EMT is a pre-requisite for subsequent Id1-induced MET during lung colonization. Collectively, these studies underscore the importance of Id-mediated phenotypic switching during distinct stages of breast cancer metastasis. PMID:24332369
Petzoldt, Astrid G; Coutelis, Jean-Baptiste; Géminard, Charles; Spéder, Pauline; Suzanne, Magali; Cerezo, Delphine; Noselli, Stéphane
2012-05-01
In bilateria, positioning and looping of visceral organs requires proper left-right (L/R) asymmetry establishment. Recent work in Drosophila has identified a novel situs inversus gene encoding the unconventional type ID myosin (MyoID). In myoID mutant flies, the L/R axis is inverted, causing reversed looping of organs, such as the gut, spermiduct and genitalia. We have previously shown that MyoID interacts physically with β-Catenin, suggesting a role of the adherens junction in Drosophila L/R asymmetry. Here, we show that DE-Cadherin co-immunoprecipitates with MyoID and is required for MyoID L/R activity. We further demonstrate that MyoIC, a closely related unconventional type I myosin, can antagonize MyoID L/R activity by preventing its binding to adherens junction components, both in vitro and in vivo. Interestingly, DE-Cadherin inhibits MyoIC, providing a protective mechanism to MyoID function. Conditional genetic experiments indicate that DE-Cadherin, MyoIC and MyoID show temporal synchronicity for their function in L/R asymmetry. These data suggest that following MyoID recruitment by β-Catenin at the adherens junction, DE-Cadherin has a twofold effect on Drosophila L/R asymmetry by promoting MyoID activity and repressing that of MyoIC. Interestingly, the product of the vertebrate situs inversus gene inversin also physically interacts with β-Catenin, suggesting that the adherens junction might serve as a conserved platform for determinants to establish L/R asymmetry both in vertebrates and invertebrates.
Lai, Hsien-Tang; Kung, Pei-Tseng; Tsai, Wen-Chen
2014-12-01
Women with intellectual disabilities (ID) have cognitive impairment and communication difficulties; for both caregivers and clinical personnel, discovering the early symptoms of breast cancer among women with ID is challenging. The mammography utilization rate of women with ID was significantly lower than that of women in the general population. This study employed a 2008 database of people with disabilities in Taiwan as a research target and analyzed the mammography utilization rate of women with ID aged 50–69 years. In addition, relevant factors influencing mammography utilization among women with ID were also investigated. A total of 4370 participants were recruited and the majority were illiterate or had elementary-level educations (82.27%). The majority of the participants had ID that was more severe than mild (83.80%). The mammography utilization rate of women with ID was 4.32%, which was significantly lower than that of women in the general population (12%). The mammography utilization rate among women with ID who were married, had higher education levels, and had been diagnosed with cancer, diabetes, or mild ID was significantly higher. However, the mammography utilization rate among women with ID, who had elementary-level educations or were illiterate, was only 4.03%. The utilization rate among women with profound ID was only 2.65%. Women with ID who had undergone pap smears or had utilized adult preventive health services demonstrated a significantly higher mammography utilization rate. This study identified that education level, a diagnosis of diabetes, and the application of pap smears or adult preventive health services were primary factors that influenced the mammography utilization rate among women with ID. This study also observed that in Taiwan, the mammography utilization rate of women with ID was lower than that of pap smears and adult preventive health services, and was only half of that of people with disabilities. An unequal situation existed in regard to the acceptance of breast cancer screening among women with ID, and a different form of strategic planning must be adopted in public health policy. Because ID differs from other disabilities and most women with ID are illiterate, tailored courses are required to train primary caregivers and clinical personnel in providing knowledge and services. The objectives are to diagnose breast cancer at an early stage to decrease the risk of mortality and ensure their rights to health.
Santos, Denise CC; Angulo-Barroso, Rosa M; Li, Ming; Bian, Yang; Sturza, Julie; Richards, Blair; Lozoff, Betsy
2017-01-01
BACKGROUND/OBJECTIVES Poorer motor development is reported in infants with iron deficiency (ID). The role of timing, duration and severity is unclear. We assessed relations between ID timing, duration, and severity and gross motor scores, neurological integrity, and motor behavior quality at 9 months. METHODS Iron status was determined at birth and 9 months in otherwise healthy term Chinese infants. The 9-month motor evaluation included the Peabody Developmental Motor Scale (PDMS-2), Infant Neurological International Battery (INFANIB), and motor quality factor. Motor outcomes were analyzed by ID timing (fetal-neonatal, infancy), duration, and severity. For severity, we also considered maternal iron status. RESULTS Data were available for 1194 infants. Iron status was classified as fetal-neonatal and infancy ID (n=253), fetal-neonatal ID (n=256), infancy ID (n=288), and not ID (n=397). Compared with not ID, infants with fetal-neonatal or infancy ID had lower locomotion scores (effect size ds=0.19, 0.18) and those with ID in both periods (longer duration) had lower locomotion and overall PDMS-2 gross motor scores (ds=0.20, 0.18); ID groups did not differ. More severe ID in late pregnancy was associated with lower INFANIB Vestibular function (p=0.01), and total score (p=0.03). More severe ID in infancy was associated with lower scores for locomotion (p=0.03), overall gross motor (p=0.05). CONCLUSIONS Fetal-neonatal and/or infancy ID was associated with lower overall gross motor development and locomotion test scores at 9 months. Associations with ID severity varied by ID timing: more severe ID in late pregnancy, poorer neurological integrity; more severe ID in infancy, poorer gross motor development. PMID:29235557