Heterogeneous conservation of Dlx paralog co-expression in jawed vertebrates.

PubMed

Debiais-Thibaud, Mélanie; Metcalfe, Cushla J; Pollack, Jacob; Germon, Isabelle; Ekker, Marc; Depew, Michael; Laurenti, Patrick; Borday-Birraux, Véronique; Casane, Didier

2013-01-01

The Dlx gene family encodes transcription factors involved in the development of a wide variety of morphological innovations that first evolved at the origins of vertebrates or of the jawed vertebrates. This gene family expanded with the two rounds of genome duplications that occurred before jawed vertebrates diversified. It includes at least three bigene pairs sharing conserved regulatory sequences in tetrapods and teleost fish, but has been only partially characterized in chondrichthyans, the third major group of jawed vertebrates. Here we take advantage of developmental and molecular tools applied to the shark Scyliorhinus canicula to fill in the gap and provide an overview of the evolution of the Dlx family in the jawed vertebrates. These results are analyzed in the theoretical framework of the DDC (Duplication-Degeneration-Complementation) model. The genomic organisation of the catshark Dlx genes is similar to that previously described for tetrapods. Conserved non-coding elements identified in bony fish were also identified in catshark Dlx clusters and showed regulatory activity in transgenic zebrafish. Gene expression patterns in the catshark showed that there are some expression sites with high conservation of the expressed paralog(s) and other expression sites with events of paralog sub-functionalization during jawed vertebrate diversification, resulting in a wide variety of evolutionary scenarios within this gene family. Dlx gene expression patterns in the catshark show that there has been little neo-functionalization in Dlx genes over gnathostome evolution. In most cases, one tandem duplication and two rounds of vertebrate genome duplication have led to at least six Dlx coding sequences with redundant expression patterns followed by some instances of paralog sub-functionalization. Regulatory constraints such as shared enhancers, and functional constraints including gene pleiotropy, may have contributed to the evolutionary inertia leading to high redundancy between gene expression patterns.

Saccharomyces cerevisiae Bat1 and Bat2 Aminotransferases Have Functionally Diverged from the Ancestral-Like Kluyveromyces lactis Orthologous Enzyme

PubMed Central

Colón, Maritrini; Hernández, Fabiola; López, Karla; Quezada, Héctor; González, James; López, Geovani; Aranda, Cristina; González, Alicia

2011-01-01

Background Gene duplication is a key evolutionary mechanism providing material for the generation of genes with new or modified functions. The fate of duplicated gene copies has been amply discussed and several models have been put forward to account for duplicate conservation. The specialization model considers that duplication of a bifunctional ancestral gene could result in the preservation of both copies through subfunctionalization, resulting in the distribution of the two ancestral functions between the gene duplicates. Here we investigate whether the presumed bifunctional character displayed by the single branched chain amino acid aminotransferase present in K. lactis has been distributed in the two paralogous genes present in S. cerevisiae, and whether this conservation has impacted S. cerevisiae metabolism. Principal Findings Our results show that the KlBat1 orthologous BCAT is a bifunctional enzyme, which participates in the biosynthesis and catabolism of branched chain aminoacids (BCAAs). This dual role has been distributed in S. cerevisiae Bat1 and Bat2 paralogous proteins, supporting the specialization model posed to explain the evolution of gene duplications. BAT1 is highly expressed under biosynthetic conditions, while BAT2 expression is highest under catabolic conditions. Bat1 and Bat2 differential relocalization has favored their physiological function, since biosynthetic precursors are generated in the mitochondria (Bat1), while catabolic substrates are accumulated in the cytosol (Bat2). Under respiratory conditions, in the presence of ammonium and BCAAs the bat1Δ bat2Δ double mutant shows impaired growth, indicating that Bat1 and Bat2 could play redundant roles. In K. lactis wild type growth is independent of BCAA degradation, since a Klbat1Δ mutant grows under this condition. Conclusions Our study shows that BAT1 and BAT2 differential expression and subcellular relocalization has resulted in the distribution of the biosynthetic and catabolic roles of the ancestral BCAT in two isozymes improving BCAAs metabolism and constituting an adaptation to facultative metabolism. PMID:21267457

Structure and transcriptional regulation of the major intrinsic protein gene family in grapevine.

PubMed

Wong, Darren Chern Jan; Zhang, Li; Merlin, Isabelle; Castellarin, Simone D; Gambetta, Gregory A

2018-04-11

The major intrinsic protein (MIP) family is a family of proteins, including aquaporins, which facilitate water and small molecule transport across plasma membranes. In plants, MIPs function in a huge variety of processes including water transport, growth, stress response, and fruit development. In this study, we characterize the structure and transcriptional regulation of the MIP family in grapevine, describing the putative genome duplication events leading to the family structure and characterizing the family's tissue and developmental specific expression patterns across numerous preexisting microarray and RNAseq datasets. Gene co-expression network (GCN) analyses were carried out across these datasets and the promoters of each family member were analyzed for cis-regulatory element structure in order to provide insight into their transcriptional regulation. A total of 29 Vitis vinifera MIP family members (excluding putative pseudogenes) were identified of which all but two were mapped onto Vitis vinifera chromosomes. In this study, segmental duplication events were identified for five plasma membrane intrinsic protein (PIP) and four tonoplast intrinsic protein (TIP) genes, contributing to the expansion of PIPs and TIPs in grapevine. Grapevine MIP family members have distinct tissue and developmental expression patterns and hierarchical clustering revealed two primary groups regardless of the datasets analyzed. Composite microarray and RNA-seq gene co-expression networks (GCNs) highlighted the relationships between MIP genes and functional categories involved in cell wall modification and transport, as well as with other MIPs revealing a strong co-regulation within the family itself. Some duplicated MIP family members have undergone sub-functionalization and exhibit distinct expression patterns and GCNs. Cis-regulatory element (CRE) analyses of the MIP promoters and their associated GCN members revealed enrichment for numerous CREs including AP2/ERFs and NACs. Combining phylogenetic analyses, gene expression profiling, gene co-expression network analyses, and cis-regulatory element enrichment, this study provides a comprehensive overview of the structure and transcriptional regulation of the grapevine MIP family. The study highlights the duplication and sub-functionalization of the family, its strong coordinated expression with genes involved in growth and transport, and the putative classes of TFs responsible for its regulation.

Duplication and diversification of the LEAFY HULL STERILE1 and Oryza sativa MADS5 SEPALLATA lineages in graminoid Poales

PubMed Central

2012-01-01

Background Gene duplication and the subsequent divergence in function of the resulting paralogs via subfunctionalization and/or neofunctionalization is hypothesized to have played a major role in the evolution of plant form. The LEAFY HULL STERILE1 (LHS1) SEPALLATA (SEP) genes have been linked with the origin and diversification of the grass spikelet, but it is uncertain 1) when the duplication event that produced the LHS1 clade and its paralogous lineage Oryza sativa MADS5 (OSM5) occurred, and 2) how changes in gene structure and/or expression might have contributed to subfunctionalization and/or neofunctionalization in the two lineages. Methods Phylogenetic relationships among 84 SEP genes were estimated using Bayesian methods. RNA expression patterns were inferred using in situ hybridization. The patterns of protein sequence and RNA expression evolution were reconstructed using maximum parsimony (MP) and maximum likelihood (ML) methods, respectively. Results Phylogenetic analyses mapped the LHS1/OSM5 duplication event to the base of the grass family. MP character reconstructions estimated a change from cytosine to thymine in the first codon position of the first amino acid after the Zea mays MADS3 (ZMM3) domain converted a glutamine to a stop codon in the OSM5 ancestor following the LHS1/OSM5 duplication event. RNA expression analyses of OSM5 co-orthologs in Avena sativa, Chasmanthium latifolium, Hordeum vulgare, Pennisetum glaucum, and Sorghum bicolor followed by ML reconstructions of these data and previously published analyses estimated a complex pattern of gain and loss of LHS1 and OSM5 expression in different floral organs and different flowers within the spikelet or inflorescence. Conclusions Previous authors have reported that rice OSM5 and LHS1 proteins have different interaction partners indicating that the truncation of OSM5 following the LHS1/OSM5 duplication event has resulted in both partitioned and potentially novel gene functions. The complex pattern of OSM5 and LHS1 expression evolution is not consistent with a simple subfunctionalization model following the gene duplication event, but there is evidence of recent partitioning of OSM5 and LHS1 expression within different floral organs of A. sativa, C. latifolium, P. glaucum and S. bicolor, and between the upper and lower florets of the two-flowered maize spikelet. PMID:22340849

Reconstructing the Evolutionary History of Paralogous APETALA1/FRUITFULL-Like Genes in Grasses (Poaceae)

PubMed Central

Preston, Jill C.; Kellogg, Elizabeth A.

2006-01-01

Gene duplication is an important mechanism for the generation of evolutionary novelty. Paralogous genes that are not silenced may evolve new functions (neofunctionalization) that will alter the developmental outcome of preexisting genetic pathways, partition ancestral functions (subfunctionalization) into divergent developmental modules, or function redundantly. Functional divergence can occur by changes in the spatio-temporal patterns of gene expression and/or by changes in the activities of their protein products. We reconstructed the evolutionary history of two paralogous monocot MADS-box transcription factors, FUL1 and FUL2, and determined the evolution of sequence and gene expression in grass AP1/FUL-like genes. Monocot AP1/FUL-like genes duplicated at the base of Poaceae and codon substitutions occurred under relaxed selection mostly along the branch leading to FUL2. Following the duplication, FUL1 was apparently lost from early diverging taxa, a pattern consistent with major changes in grass floral morphology. Overlapping gene expression patterns in leaves and spikelets indicate that FUL1 and FUL2 probably share some redundant functions, but that FUL2 may have become temporally restricted under partial subfunctionalization to particular stages of floret development. These data have allowed us to reconstruct the history of AP1/FUL-like genes in Poaceae and to hypothesize a role for this gene duplication in the evolution of the grass spikelet. PMID:16816429

Expansion of banana (Musa acuminata) gene families involved in ethylene biosynthesis and signalling after lineage-specific whole-genome duplications.

PubMed

Jourda, Cyril; Cardi, Céline; Mbéguié-A-Mbéguié, Didier; Bocs, Stéphanie; Garsmeur, Olivier; D'Hont, Angélique; Yahiaoui, Nabila

2014-05-01

Whole-genome duplications (WGDs) are widespread in plants, and three lineage-specific WGDs occurred in the banana (Musa acuminata) genome. Here, we analysed the impact of WGDs on the evolution of banana gene families involved in ethylene biosynthesis and signalling, a key pathway for banana fruit ripening. Banana ethylene pathway genes were identified using comparative genomics approaches and their duplication modes and expression profiles were analysed. Seven out of 10 banana ethylene gene families evolved through WGD and four of them (1-aminocyclopropane-1-carboxylate synthase (ACS), ethylene-insensitive 3-like (EIL), ethylene-insensitive 3-binding F-box (EBF) and ethylene response factor (ERF)) were preferentially retained. Banana orthologues of AtEIN3 and AtEIL1, two major genes for ethylene signalling in Arabidopsis, were particularly expanded. This expansion was paralleled by that of EBF genes which are responsible for control of EIL protein levels. Gene expression profiles in banana fruits suggested functional redundancy for several MaEBF and MaEIL genes derived from WGD and subfunctionalization for some of them. We propose that EIL and EBF genes were co-retained after WGD in banana to maintain balanced control of EIL protein levels and thus avoid detrimental effects of constitutive ethylene signalling. In the course of evolution, subfunctionalization was favoured to promote finer control of ethylene signalling. © 2014 CIRAD New Phytologist © 2014 New Phytologist Trust.

Sequencing and analysis of 10967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morin, R D; Chang, E; Petrescu, A

2005-10-31

Sequencing of full-insert clones from full-length cDNA libraries from both Xenopus laevis and Xenopus tropicalis has been ongoing as part of the Xenopus Gene Collection initiative. Here we present an analysis of 10967 clones (8049 from X. laevis and 2918 from X. tropicalis). The clone set contains 2013 orthologs between X. laevis and X. tropicalis as well as 1795 paralog pairs within X. laevis. 1199 are in-paralogs, believed to have resulted from an allotetraploidization event approximately 30 million years ago, and the remaining 546 are likely out-paralogs that have resulted from more ancient gene duplications, prior to the divergence betweenmore » the two species. We do not detect any evidence for positive selection by the Yang and Nielsen maximum likelihood method of approximating d{sub N}/d{sub S}. However, d{sub N}/d{sub S} for X. laevis in-paralogs is elevated relative to X. tropicalis orthologs. This difference is highly significant, and indicates an overall relaxation of selective pressures on duplicated gene pairs. Within both groups of paralogs, we found evidence of subfunctionalization, manifested as differential expression of paralogous genes among tissues, as measured by EST information from public resources. We have observed, as expected, a higher instance of subfunctionalization in out-paralogs relative to in-paralogs.« less

Redefining C and D in the petunia ABC.

PubMed

Heijmans, Klaas; Ament, Kai; Rijpkema, Anneke S; Zethof, Jan; Wolters-Arts, Mieke; Gerats, Tom; Vandenbussche, Michiel

2012-06-01

According to the ABC(DE) model for flower development, C-genes are required for stamen and carpel development and floral determinacy, and D-genes were proposed to play a unique role in ovule development. Both C- and D-genes belong to the AGAMOUS (AG) subfamily of MADS box transcription factors. We show that the petunia (Petunia hybrida) C-clade genes PETUNIA MADS BOX GENE3 and FLORAL BINDING PROTEIN6 (FBP6) largely overlap in function, both in floral organ identity specification and floral determinacy, unlike the pronounced subfunctionalization observed in Arabidopsis thaliana and snapdragon (Antirrhinum majus). Some specialization has also evolved, since FBP6 plays a unique role in the development of the style and stigma. Furthermore, we show that the D-genes FBP7 and FBP11 are not essential to confer ovule identity. Instead, this function is redundantly shared among all AG members. In turn, the D-genes also participate in floral determinacy. Gain-of-function analyses suggest the presence of a posttranscriptional C-repression mechanism in petunia, most likely not existing in Arabidopsis. Finally, we show that expression maintenance of the paleoAPETALA3-type B-gene TOMATO MADS BOX GENE6 depends on the activity of C-genes. Taken together, this demonstrates considerable variation in the molecular control of floral development between eudicot species.

Redefining C and D in the Petunia ABC[W

PubMed Central

Heijmans, Klaas; Ament, Kai; Rijpkema, Anneke S.; Zethof, Jan; Wolters-Arts, Mieke; Gerats, Tom; Vandenbussche, Michiel

2012-01-01

According to the ABC(DE) model for flower development, C-genes are required for stamen and carpel development and floral determinacy, and D-genes were proposed to play a unique role in ovule development. Both C- and D-genes belong to the AGAMOUS (AG) subfamily of MADS box transcription factors. We show that the petunia (Petunia hybrida) C-clade genes PETUNIA MADS BOX GENE3 and FLORAL BINDING PROTEIN6 (FBP6) largely overlap in function, both in floral organ identity specification and floral determinacy, unlike the pronounced subfunctionalization observed in Arabidopsis thaliana and snapdragon (Antirrhinum majus). Some specialization has also evolved, since FBP6 plays a unique role in the development of the style and stigma. Furthermore, we show that the D-genes FBP7 and FBP11 are not essential to confer ovule identity. Instead, this function is redundantly shared among all AG members. In turn, the D-genes also participate in floral determinacy. Gain-of-function analyses suggest the presence of a posttranscriptional C-repression mechanism in petunia, most likely not existing in Arabidopsis. Finally, we show that expression maintenance of the paleoAPETALA3-type B-gene TOMATO MADS BOX GENE6 depends on the activity of C-genes. Taken together, this demonstrates considerable variation in the molecular control of floral development between eudicot species. PMID:22706285

Protein domain evolution is associated with reproductive diversification and adaptive radiation in the genus Eucalyptus.

PubMed

Kersting, Anna R; Mizrachi, Eshchar; Bornberg-Bauer, Erich; Myburg, Alexander A

2015-06-01

Eucalyptus is a pivotal genus within the rosid order Myrtales with distinct geographic history and adaptations. Comparative analysis of protein domain evolution in the newly sequenced Eucalyptus grandis genome and other rosid lineages sheds light on the adaptive mechanisms integral to the success of this genus of woody perennials. We reconstructed the ancestral domain content to elucidate the gain, loss and expansion of protein domains and domain arrangements in Eucalyptus in the context of rosid phylogeny. We used functional gene ontology (GO) annotation of genes to investigate the possible biological and evolutionary consequences of protein domain expansion. We found that protein modulation within the angiosperms occurred primarily on the level of expansion of certain domains and arrangements. Using RNA-Seq data from E. grandis, we showed that domain expansions have contributed to tissue-specific expression of tandemly duplicated genes. Our results indicate that tandem duplication of genes, a key feature of the Eucalyptus genome, has played an important role in the expansion of domains, particularly in proteins related to the specialization of reproduction and biotic and abiotic interactions affecting root and floral biology, and that tissue-specific expression of proteins with expanded domains has facilitated subfunctionalization in domain families. © 2014 University of Pretoria New Phytologist © 2014 New Phytologist Trust.

Population Level Purifying Selection and Gene Expression Shape Subgenome Evolution in Maize.

PubMed

Pophaly, Saurabh D; Tellier, Aurélien

2015-12-01

The maize ancestor experienced a recent whole-genome duplication (WGD) followed by gene erosion which generated two subgenomes, the dominant subgenome (maize1) experiencing fewer deletions than maize2. We take advantage of available extensive polymorphism and gene expression data in maize to study purifying selection and gene expression divergence between WGD retained paralog pairs. We first report a strong correlation in nucleotide diversity between duplicate pairs, except for upstream regions. We then show that maize1 genes are under stronger purifying selection than maize2. WGD retained genes have higher gene dosage and biased Gene Ontologies consistent with previous studies. The relative gene expression of paralogs across tissues demonstrates that 98% of duplicate pairs have either subfunctionalized in a tissuewise manner or have diverged consistently in their expression thereby preventing functional complementation. Tissuewise subfunctionalization seems to be a hallmark of transcription factors, whereas consistent repression occurs for macromolecular complexes. We show that dominant gene expression is a strong determinant of the strength of purifying selection, explaining the inferred stronger negative selection on maize1 genes. We propose a novel expression-based classification of duplicates which is more robust to explain observed polymorphism patterns than the subgenome location. Finally, upstream regions of repressed genes exhibit an enrichment in transposable elements which indicates a possible mechanism for expression divergence. © The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Evolution of the duplicated intracellular lipid-binding protein genes of teleost fishes.

PubMed

Venkatachalam, Ananda B; Parmar, Manoj B; Wright, Jonathan M

2017-08-01

Increasing organismal complexity during the evolution of life has been attributed to the duplication of genes and entire genomes. More recently, theoretical models have been proposed that postulate the fate of duplicated genes, among them the duplication-degeneration-complementation (DDC) model. In the DDC model, the common fate of a duplicated gene is lost from the genome owing to nonfunctionalization. Duplicated genes are retained in the genome either by subfunctionalization, where the functions of the ancestral gene are sub-divided between the sister duplicate genes, or by neofunctionalization, where one of the duplicate genes acquires a new function. Both processes occur either by loss or gain of regulatory elements in the promoters of duplicated genes. Here, we review the genomic organization, evolution, and transcriptional regulation of the multigene family of intracellular lipid-binding protein (iLBP) genes from teleost fishes. Teleost fishes possess many copies of iLBP genes owing to a whole genome duplication (WGD) early in the teleost fish radiation. Moreover, the retention of duplicated iLBP genes is substantially higher than the retention of all other genes duplicated in the teleost genome. The fatty acid-binding protein genes, a subfamily of the iLBP multigene family in zebrafish, are differentially regulated by peroxisome proliferator-activated receptor (PPAR) isoforms, which may account for the retention of iLBP genes in the zebrafish genome by the process of subfunctionalization of cis-acting regulatory elements in iLBP gene promoters.

A Synergism between Adaptive Effects and Evolvability Drives Whole Genome Duplication to Fixation

PubMed Central

Cuypers, Thomas D.; Hogeweg, Paulien

2014-01-01

Whole genome duplication has shaped eukaryotic evolutionary history and has been associated with drastic environmental change and species radiation. While the most common fate of WGD duplicates is a return to single copy, retained duplicates have been found enriched for highly interacting genes. This pattern has been explained by a neutral process of subfunctionalization and more recently, dosage balance selection. However, much about the relationship between environmental change, WGD and adaptation remains unknown. Here, we study the duplicate retention pattern postWGD, by letting virtual cells adapt to environmental changes. The virtual cells have structured genomes that encode a regulatory network and simple metabolism. Populations are under selection for homeostasis and evolve by point mutations, small indels and WGD. After populations had initially adapted fully to fluctuating resource conditions re-adaptation to a broad range of novel environments was studied by tracking mutations in the line of descent. WGD was established in a minority (≈30%) of lineages, yet, these were significantly more successful at re-adaptation. Unexpectedly, WGD lineages conserved more seemingly redundant genes, yet had higher per gene mutation rates. While WGD duplicates of all functional classes were significantly over-retained compared to a model of neutral losses, duplicate retention was clearly biased towards highly connected TFs. Importantly, no subfunctionalization occurred in conserved pairs, strongly suggesting that dosage balance shaped retention. Meanwhile, singles diverged significantly. WGD, therefore, is a powerful mechanism to cope with environmental change, allowing conservation of a core machinery, while adapting the peripheral network to accommodate change. PMID:24743268

A synergism between adaptive effects and evolvability drives whole genome duplication to fixation.

PubMed

Cuypers, Thomas D; Hogeweg, Paulien

2014-04-01

Whole genome duplication has shaped eukaryotic evolutionary history and has been associated with drastic environmental change and species radiation. While the most common fate of WGD duplicates is a return to single copy, retained duplicates have been found enriched for highly interacting genes. This pattern has been explained by a neutral process of subfunctionalization and more recently, dosage balance selection. However, much about the relationship between environmental change, WGD and adaptation remains unknown. Here, we study the duplicate retention pattern postWGD, by letting virtual cells adapt to environmental changes. The virtual cells have structured genomes that encode a regulatory network and simple metabolism. Populations are under selection for homeostasis and evolve by point mutations, small indels and WGD. After populations had initially adapted fully to fluctuating resource conditions re-adaptation to a broad range of novel environments was studied by tracking mutations in the line of descent. WGD was established in a minority (≈30%) of lineages, yet, these were significantly more successful at re-adaptation. Unexpectedly, WGD lineages conserved more seemingly redundant genes, yet had higher per gene mutation rates. While WGD duplicates of all functional classes were significantly over-retained compared to a model of neutral losses, duplicate retention was clearly biased towards highly connected TFs. Importantly, no subfunctionalization occurred in conserved pairs, strongly suggesting that dosage balance shaped retention. Meanwhile, singles diverged significantly. WGD, therefore, is a powerful mechanism to cope with environmental change, allowing conservation of a core machinery, while adapting the peripheral network to accommodate change.

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.

PubMed

Braasch, Ingo; Gehrke, Andrew R; Smith, Jeramiah J; Kawasaki, Kazuhiko; Manousaki, Tereza; Pasquier, Jeremy; Amores, Angel; Desvignes, Thomas; Batzel, Peter; Catchen, Julian; Berlin, Aaron M; Campbell, Michael S; Barrell, Daniel; Martin, Kyle J; Mulley, John F; Ravi, Vydianathan; Lee, Alison P; Nakamura, Tetsuya; Chalopin, Domitille; Fan, Shaohua; Wcisel, Dustin; Cañestro, Cristian; Sydes, Jason; Beaudry, Felix E G; Sun, Yi; Hertel, Jana; Beam, Michael J; Fasold, Mario; Ishiyama, Mikio; Johnson, Jeremy; Kehr, Steffi; Lara, Marcia; Letaw, John H; Litman, Gary W; Litman, Ronda T; Mikami, Masato; Ota, Tatsuya; Saha, Nil Ratan; Williams, Louise; Stadler, Peter F; Wang, Han; Taylor, John S; Fontenot, Quenton; Ferrara, Allyse; Searle, Stephen M J; Aken, Bronwen; Yandell, Mark; Schneider, Igor; Yoder, Jeffrey A; Volff, Jean-Nicolas; Meyer, Axel; Amemiya, Chris T; Venkatesh, Byrappa; Holland, Peter W H; Guiguen, Yann; Bobe, Julien; Shubin, Neil H; Di Palma, Federica; Alföldi, Jessica; Lindblad-Toh, Kerstin; Postlethwait, John H

2016-04-01

To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences.

Genome evolution and speciation genetics of clawed frogs (Xenopus and Silurana).

PubMed

Evans, Ben J

2008-05-01

Speciation of clawed frogs occurred through bifurcation and reticulation of evolutionary lineages, and resulted in extant species with different ploidy levels. Duplicate gene evolution and expression in these animals provides a unique perspective into the earliest genomic transformations after vertebrate whole genome duplication (WGD) and suggests that functional constraints are relaxed compared to before duplication but still consistently strong for millions of years following WGD. Additionally, extensive quantitative expression divergence between duplicate genes occurred after WGD. Diversification of clawed frogs was potentially catalyzed by transposition and divergent resolution--processes that occur through different genetic mechanisms but that have analogous implications for genome structure. How sex determination is maintained after genome duplication is fundamental to our understanding of why allopolyploidization is so prevalent in this group, and why clawed frogs violate Haldane's Rule for hybrid sterility. Future studies of expression subfunctionalization in polyploids will shed light on the role and purviews of cis- and trans-regulatory elements in gene regulation.

The spotted gar genome illuminates vertebrate evolution and facilitates human-to-teleost comparisons

PubMed Central

Braasch, Ingo; Gehrke, Andrew R.; Smith, Jeramiah J.; Kawasaki, Kazuhiko; Manousaki, Tereza; Pasquier, Jeremy; Amores, Angel; Desvignes, Thomas; Batzel, Peter; Catchen, Julian; Berlin, Aaron M.; Campbell, Michael S.; Barrell, Daniel; Martin, Kyle J.; Mulley, John F.; Ravi, Vydianathan; Lee, Alison P.; Nakamura, Tetsuya; Chalopin, Domitille; Fan, Shaohua; Wcisel, Dustin; Cañestro, Cristian; Sydes, Jason; Beaudry, Felix E. G.; Sun, Yi; Hertel, Jana; Beam, Michael J.; Fasold, Mario; Ishiyama, Mikio; Johnson, Jeremy; Kehr, Steffi; Lara, Marcia; Letaw, John H.; Litman, Gary W.; Litman, Ronda T.; Mikami, Masato; Ota, Tatsuya; Saha, Nil Ratan; Williams, Louise; Stadler, Peter F.; Wang, Han; Taylor, John S.; Fontenot, Quenton; Ferrara, Allyse; Searle, Stephen M. J.; Aken, Bronwen; Yandell, Mark; Schneider, Igor; Yoder, Jeffrey A.; Volff, Jean-Nicolas; Meyer, Axel; Amemiya, Chris T.; Venkatesh, Byrappa; Holland, Peter W. H.; Guiguen, Yann; Bobe, Julien; Shubin, Neil H.; Di Palma, Federica; Alföldi, Jessica; Lindblad-Toh, Kerstin; Postlethwait, John H.

2016-01-01

To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before the teleost genome duplication (TGD). The slowly evolving gar genome conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization, and development (e.g., Hox, ParaHox, and miRNA genes). Numerous conserved non-coding elements (CNEs, often cis-regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles of such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses revealed that the sum of expression domains and levels from duplicated teleost genes often approximate patterns and levels of gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes, and the function of human regulatory sequences. PMID:26950095

Lineage-specific co-evolution of the Egf receptor/ligand signaling system.

PubMed

Laisney, Juliette A G C; Braasch, Ingo; Walter, Ronald B; Meierjohann, Svenja; Schartl, Manfred

2010-01-27

The epidermal growth factor receptor (Egfr) with its numerous ligands has fundamental roles in development, cell differentiation and physiology. Dysfunction of the receptor-ligand system contributes to many human malignancies. Consistent with such various tasks, the Egfr gene family has expanded during vertebrate evolution as a consequence of several rounds of whole genome duplication. Of particular interest is the effect of the fish-specific whole genome duplication (FSGD) on the ligand-receptor system, as it has supplied this largest group of vertebrates with additional opportunities for sub- and/or neofunctionalization in this signaling system. We identified the predicted components of the Egf receptor-ligand signaling system in teleost fishes (medaka, platyfish, stickleback, pufferfishes and zebrafish). We found two duplicated egfr genes, egfra and egfrb, in all available teleost genomes. Surprisingly only one copy for each of the seven Egfr ligands could be identified in most fishes, with zebrafish hbegf being the only exception. Special focus was put on medaka, for which we more closely investigated all Egf receptors and Egfr ligands. The different expression patterns of egfra, egfrb and their ligands in medaka tissues and embryo stages suggest differences in role and function. Preferential co-expression of different subsets of Egfr ligands corroborates the possible subfunctionalization and specialization of the two receptors in adult tissues. Bioinformatic analyses of the ligand-receptor interface between Egfr and its ligands show a very weak evolutionary conservation within this region. Using in vitro analyses of medaka Egfra, we could show that this receptor is only activated by medaka ligands, but not by human EGF. Altogether, our data suggest a lineage-specific Egfr/Egfr ligand co-evolution. Our data indicate that medaka Egfr signaling occurs via its two copies, Egfra and Egfrb, each of them being preferentially coexpressed with different subsets of Egfr ligands. This fish-specific occurrence of Egf receptor specialization offers unique opportunities to study the functions of different Egf receptor-ligand combinations and their biological outputs in vertebrates. Furthermore, our results strongly support the use of homologous ligands in future studies, as sufficient cross-specificity is very unlikely for this ligand/receptor system.

Lineage-specific co-evolution of the Egf receptor/ligand signaling system

PubMed Central

2010-01-01

Background The epidermal growth factor receptor (Egfr) with its numerous ligands has fundamental roles in development, cell differentiation and physiology. Dysfunction of the receptor-ligand system contributes to many human malignancies. Consistent with such various tasks, the Egfr gene family has expanded during vertebrate evolution as a consequence of several rounds of whole genome duplication. Of particular interest is the effect of the fish-specific whole genome duplication (FSGD) on the ligand-receptor system, as it has supplied this largest group of vertebrates with additional opportunities for sub- and/or neofunctionalization in this signaling system. Results We identified the predicted components of the Egf receptor-ligand signaling system in teleost fishes (medaka, platyfish, stickleback, pufferfishes and zebrafish). We found two duplicated egfr genes, egfra and egfrb, in all available teleost genomes. Surprisingly only one copy for each of the seven Egfr ligands could be identified in most fishes, with zebrafish hbegf being the only exception. Special focus was put on medaka, for which we more closely investigated all Egf receptors and Egfr ligands. The different expression patterns of egfra, egfrb and their ligands in medaka tissues and embryo stages suggest differences in role and function. Preferential co-expression of different subsets of Egfr ligands corroborates the possible subfunctionalization and specialization of the two receptors in adult tissues. Bioinformatic analyses of the ligand-receptor interface between Egfr and its ligands show a very weak evolutionary conservation within this region. Using in vitro analyses of medaka Egfra, we could show that this receptor is only activated by medaka ligands, but not by human EGF. Altogether, our data suggest a lineage-specific Egfr/Egfr ligand co-evolution. Conclusions Our data indicate that medaka Egfr signaling occurs via its two copies, Egfra and Egfrb, each of them being preferentially coexpressed with different subsets of Egfr ligands. This fish-specific occurrence of Egf receptor specialization offers unique opportunities to study the functions of different Egf receptor-ligand combinations and their biological outputs in vertebrates. Furthermore, our results strongly support the use of homologous ligands in future studies, as sufficient cross-specificity is very unlikely for this ligand/receptor system. PMID:20105326

Comparative analysis of protein-protein interactions in the defense response of rice and wheat.

PubMed

Cantu, Dario; Yang, Baoju; Ruan, Randy; Li, Kun; Menzo, Virginia; Fu, Daolin; Chern, Mawsheng; Ronald, Pamela C; Dubcovsky, Jorge

2013-03-12

Despite the importance of wheat as a major staple crop and the negative impact of diseases on its production worldwide, the genetic mechanisms and gene interactions involved in the resistance response in wheat are still poorly understood. The complete sequence of the rice genome has provided an extremely useful parallel road map for genetic and genomics studies in wheat. The recent construction of a defense response interactome in rice has the potential to further enhance the translation of advances in rice to wheat and other grasses. The objective of this study was to determine the degree of conservation in the protein-protein interactions in the rice and wheat defense response interactomes. As entry points we selected proteins that serve as key regulators of the rice defense response: the RAR1/SGT1/HSP90 protein complex, NPR1, XA21, and XB12 (XA21 interacting protein 12). Using available wheat sequence databases and phylogenetic analyses we identified and cloned the wheat orthologs of these four rice proteins, including recently duplicated paralogs, and their known direct interactors and tested 86 binary protein interactions using yeast-two-hybrid (Y2H) assays. All interactions between wheat proteins were further tested using in planta bimolecular fluorescence complementation (BiFC). Eighty three percent of the known rice interactions were confirmed when wheat proteins were tested with rice interactors and 76% were confirmed using wheat protein pairs. All interactions in the RAR1/SGT1/ HSP90, NPR1 and XB12 nodes were confirmed for the identified orthologous wheat proteins, whereas only forty four percent of the interactions were confirmed in the interactome node centered on XA21. We hypothesize that this reduction may be associated with a different sub-functionalization history of the multiple duplications that occurred in this gene family after the divergence of the wheat and rice lineages. The observed high conservation of interactions between proteins that serve as key regulators of the rice defense response suggests that the existing rice interactome can be used to predict interactions in wheat. Such predictions are less reliable for nodes that have undergone a different history of duplications and sub-functionalization in the two lineages.

Bacillus subtilis ribonucleases J1 and J2 form a complex with altered enzyme behaviour.

PubMed

Mathy, Nathalie; Hébert, Agnès; Mervelet, Peggy; Bénard, Lionel; Dorléans, Audrey; Li de la Sierra-Gallay, Inés; Noirot, Philippe; Putzer, Harald; Condon, Ciarán

2010-01-01

Ribonucleases J1 and J2 are recently discovered enzymes with dual 5'-to-3' exoribonucleolytic/endoribonucleolytic activity that plays a key role in the maturation and degradation of Bacillus subtilis RNAs. RNase J1 is essential, while its paralogue RNase J2 is not. Up to now, it had generally been assumed that the two enzymes functioned independently. Here we present evidence that RNases J1 and J2 form a complex that is likely to be the predominant form of these enzymes in wild-type cells. While both RNase J1 and the RNase J1/J2 complex have robust 5'-to-3' exoribonuclease activity in vitro, RNase J2 has at least two orders of magnitude weaker exonuclease activity, providing a possible explanation for why RNase J1 is essential. The association of the two proteins also has an effect on the endoribonucleolytic properties of RNases J1 and J2. While the individual enzymes have similar endonucleolytic cleavage activities and specificities, as a complex they behave synergistically to alter cleavage site preference and to increase cleavage efficiency at specific sites. These observations dramatically change our perception of how these ribonucleases function and provide an interesting example of enzyme subfunctionalization after gene duplication.

Legume small GTPases and their role in the establishment of symbiotic associations with Rhizobium spp

PubMed Central

Memon, Abdul R

2009-01-01

Small GTP-binding genes act as molecular switches regulating myriad of cellular processes including vesicle-mediated intracellular trafficking, signal transduction, cytoskeletal reorganization and cell division in plants and animals. Even though these genes are well conserved both functionally and sequentially across whole Eukaryotae, occasional lineage-specific diversification in some plant species in terms of both functional and expressional characteristics have been reported. Hence, comparative phyletic and correlative functional analyses of legume small GTPases homologs with the genes from other Metazoa and Embryophyta species would be very beneficial for gleaning out the small GTPases that could have specialized in legume-specific processes; e.g., nodulation. The completion of genome sequences of two model legumes, Medicago truncatula and Lotus japonicus will significantly improve our knowledge about mechanism of biological processes taking place in legume-rhizobia symbiotic associations. Besides, the need for molecular switches coordinating busy cargo-trafficking between symbiosis partners would suggest a possible subfunctionalization of small GTPases in Fabaceae for these functions. Therefore, more detailed investigation into the functional characteristics of legume small GTPases would be helpful for the illumination of the events initialized with the perception of bacteria by host, followed by the formation of infection thread and the engulfment of rhizobial bacteria, and end with the senescence of nitrogen-fixing organelles, nodules. In summary, a more thorough functional and evolutionary characterization of small GTPases across the main lineages of Embryophyta is significant for better comprehension of evolutionary history of Plantae, that is because, these genes are associated with multitude of vital biological processes including organogenesis. PMID:19794839

Heart morphogenesis gene regulatory networks revealed by temporal expression analysis.

PubMed

Hill, Jonathon T; Demarest, Bradley; Gorsi, Bushra; Smith, Megan; Yost, H Joseph

2017-10-01

During embryogenesis the heart forms as a linear tube that then undergoes multiple simultaneous morphogenetic events to obtain its mature shape. To understand the gene regulatory networks (GRNs) driving this phase of heart development, during which many congenital heart disease malformations likely arise, we conducted an RNA-seq timecourse in zebrafish from 30 hpf to 72 hpf and identified 5861 genes with altered expression. We clustered the genes by temporal expression pattern, identified transcription factor binding motifs enriched in each cluster, and generated a model GRN for the major gene batteries in heart morphogenesis. This approach predicted hundreds of regulatory interactions and found batteries enriched in specific cell and tissue types, indicating that the approach can be used to narrow the search for novel genetic markers and regulatory interactions. Subsequent analyses confirmed the GRN using two mutants, Tbx5 and nkx2-5 , and identified sets of duplicated zebrafish genes that do not show temporal subfunctionalization. This dataset provides an essential resource for future studies on the genetic/epigenetic pathways implicated in congenital heart defects and the mechanisms of cardiac transcriptional regulation. © 2017. Published by The Company of Biologists Ltd.

Analyses of the NAC transcription factor gene family in Gossypium raimondii Ulbr.: chromosomal location, structure, phylogeny, and expression patterns.

PubMed

Shang, Haihong; Li, Wei; Zou, Changsong; Yuan, Youlu

2013-07-01

NAC domain proteins are plant-specific transcription factors known to play diverse roles in various plant developmental processes. In the present study, we performed the first comprehensive study of the NAC gene family in Gossypium raimondii Ulbr., incorporating phylogenetic, chromosomal location, gene structure, conserved motif, and expression profiling analyses. We identified 145 NAC transcription factor (NAC-TF) genes that were phylogenetically clustered into 18 distinct subfamilies. Of these, 127 NAC-TF genes were distributed across the 13 chromosomes, 80 (55%) were preferentially retained duplicates located in both duplicated regions and six were located in triplicated chromosomal regions. The majority of NAC-TF genes showed temporal-, spatial-, and tissue-specific expression patterns based on transcriptomic and qRT-PCR analyses. However, the expression patterns of several duplicate genes were partially redundant, suggesting the occurrence of sub-functionalization during their evolution. Based on their genomic organization, we concluded that genomic duplications contributed significantly to the expansion of the NAC-TF gene family in G. raimondii. Comprehensive analysis of their expression profiles could provide novel insights into the functional divergence among members of the NAC gene family in G. raimondii. © 2013 Institute of Botany, Chinese Academy of Sciences.

Tissue-Specific Profiling Reveals Transcriptome Alterations in Arabidopsis Mutants Lacking Morphological Phenotypes[C][W

PubMed Central

Simon, Marissa; Bruex, Angela; Kainkaryam, Raghunandan M.; Zheng, Xiaohua; Huang, Ling; Woolf, Peter J.; Schiefelbein, John

2013-01-01

Traditional genetic analysis relies on mutants with observable phenotypes. Mutants lacking visible abnormalities may nevertheless exhibit molecular differences useful for defining gene function. To examine this, we analyzed tissue-specific transcript profiles from Arabidopsis thaliana transcription factor gene mutants with known roles in root epidermis development, but lacking a single-gene mutant phenotype due to genetic redundancy. We discovered substantial transcriptional changes in each mutant, preferentially affecting root epidermal genes in a manner consistent with the known double mutant effects. Furthermore, comparing transcript profiles of single and double mutants, we observed remarkable variation in the sensitivity of target genes to the loss of one or both paralogous genes, including preferential effects on specific branches of the epidermal gene network, likely reflecting the pathways of paralog subfunctionalization during evolution. In addition, we analyzed the root epidermal transcriptome of the transparent testa glabra2 mutant to clarify its role in the network. These findings provide insight into the molecular basis of genetic redundancy and duplicate gene diversification at the level of a specific gene regulatory network, and they demonstrate the usefulness of tissue-specific transcript profiling to define gene function in mutants lacking informative visible changes in phenotype. PMID:24014549

Two tomato GDP-D-mannose epimerase isoforms involved in ascorbate biosynthesis play specific roles in cell wall biosynthesis and development.

PubMed

Mounet-Gilbert, Louise; Dumont, Marie; Ferrand, Carine; Bournonville, Céline; Monier, Antoine; Jorly, Joana; Lemaire-Chamley, Martine; Mori, Kentaro; Atienza, Isabelle; Hernould, Michel; Stevens, Rebecca; Lehner, Arnaud; Mollet, Jean Claude; Rothan, Christophe; Lerouge, Patrice; Baldet, Pierre

2016-08-01

GDP-D-mannose epimerase (GME, EC 5.1.3.18) converts GDP-D-mannose to GDP-L-galactose, and is considered to be a central enzyme connecting the major ascorbate biosynthesis pathway to primary cell wall metabolism in higher plants. Our previous work demonstrated that GME is crucial for both ascorbate and cell wall biosynthesis in tomato. The aim of the present study was to investigate the respective role in ascorbate and cell wall biosynthesis of the two SlGME genes present in tomato by targeting each of them through an RNAi-silencing approach. Taken individually SlGME1 and SlGME2 allowed normal ascorbate accumulation in the leaf and fruits, thus suggesting the same function regarding ascorbate. However, SlGME1 and SlGME2 were shown to play distinct roles in cell wall biosynthesis, depending on the tissue considered. The RNAi-SlGME1 plants harbored small and poorly seeded fruits resulting from alterations of pollen development and of pollination process. In contrast, the RNAi-SlGME2 plants exhibited vegetative growth delay while fruits remained unaffected. Analysis of SlGME1- and SlGME2-silenced seeds and seedlings further showed that the dimerization state of pectin rhamnogalacturonan-II (RG-II) was altered only in the RNAi-SlGME2 lines. Taken together with the preferential expression of each SlGME gene in different tomato tissues, these results suggest sub-functionalization of SlGME1 and SlGME2 and their specialization for cell wall biosynthesis in specific tomato tissues. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology.

The genome sequence of Sea-Island cotton (Gossypium barbadense) provides insights into the allopolyploidization and development of superior spinnable fibres

PubMed Central

Yuan, Daojun; Tang, Zhonghui; Wang, Maojun; Gao, Wenhui; Tu, Lili; Jin, Xin; Chen, Lingling; He, Yonghui; Zhang, Lin; Zhu, Longfu; Li, Yang; Liang, Qiqi; Lin, Zhongxu; Yang, Xiyan; Liu, Nian; Jin, Shuangxia; Lei, Yang; Ding, Yuanhao; Li, Guoliang; Ruan, Xiaoan; Ruan, Yijun; Zhang, Xianlong

2015-01-01

Gossypium hirsutum contributes the most production of cotton fibre, but G. barbadense is valued for its better comprehensive resistance and superior fibre properties. However, the allotetraploid genome of G. barbadense has not been comprehensively analysed. Here we present a high-quality assembly of the 2.57 gigabase genome of G. barbadense, including 80,876 protein-coding genes. The double-sized genome of the A (or At) (1.50 Gb) against D (or Dt) (853 Mb) primarily resulted from the expansion of Gypsy elements, including Peabody and Retrosat2 subclades in the Del clade, and the Athila subclade in the Athila/Tat clade. Substantial gene expansion and contraction were observed and rich homoeologous gene pairs with biased expression patterns were identified, suggesting abundant gene sub-functionalization occurred by allopolyploidization. More specifically, the CesA gene family has adapted differentially temporal expression patterns, suggesting an integrated regulatory mechanism of CesA genes from At and Dt subgenomes for the primary and secondary cellulose biosynthesis of cotton fibre in a “relay race”-like fashion. We anticipate that the G. barbadense genome sequence will advance our understanding the mechanism of genome polyploidization and underpin genome-wide comparison research in this genus. PMID:26634818

Conserved noncoding sequences conserve biological networks and influence genome evolution.

PubMed

Xie, Jianbo; Qian, Kecheng; Si, Jingna; Xiao, Liang; Ci, Dong; Zhang, Deqiang

2018-05-01

Comparative genomics approaches have identified numerous conserved cis-regulatory sequences near genes in plant genomes. Despite the identification of these conserved noncoding sequences (CNSs), our knowledge of their functional importance and selection remains limited. Here, we used a combination of DNA methylome analysis, microarray expression analyses, and functional annotation to study these sequences in the model tree Populus trichocarpa. Methylation in CG contexts and non-CG contexts was lower in CNSs, particularly CNSs in the 5'-upstream regions of genes, compared with other sites in the genome. We observed that CNSs are enriched in genes with transcription and binding functions, and this also associated with syntenic genes and those from whole-genome duplications, suggesting that cis-regulatory sequences play a key role in genome evolution. We detected a significant positive correlation between CNS number and protein interactions, suggesting that CNSs may have roles in the evolution and maintenance of biological networks. The divergence of CNSs indicates that duplication-degeneration-complementation drives the subfunctionalization of a proportion of duplicated genes from whole-genome duplication. Furthermore, population genomics confirmed that most CNSs are under strong purifying selection and only a small subset of CNSs shows evidence of adaptive evolution. These findings provide a foundation for future studies exploring these key genomic features in the maintenance of biological networks, local adaptation, and transcription.

Floral organ MADS-box genes in Cercidiphyllum japonicum (Cercidiphyllaceae): Implications for systematic evolution and bracts definition.

PubMed

Jin, Yupei; Wang, Yubing; Zhang, Dechun; Shen, Xiangling; Liu, Wen; Chen, Faju

2017-01-01

The dioecious relic Cercidiphyllum japonicum is one of two species of the sole genus Cercidiphyllum, with a tight inflorescence lacking an apparent perianth structure. In addition, its systematic place has been much debated and, so far researches have mainly focused on its morphology and chloroplast genes. In our investigation, we identified 10 floral organ identity genes, including four A-class, three B-class, two C-class and one D-class. Phylogenetic analyses showed that all ten genes are grouped with Saxifragales plants, which confirmed the phylogenetic place of C. japonicum. Expression patterns of those genes were examined by quantitative reverse transcriptase PCR, with some variations that did not completely coincide with the ABCDE model, suggesting some subfunctionalization. As well, our research supported the idea that thebract actually is perianth according to our morphological and molecular analyses in Cercidiphyllum japonicum.

Floral organ MADS-box genes in Cercidiphyllum japonicum (Cercidiphyllaceae): Implications for systematic evolution and bracts definition

PubMed Central

Zhang, Dechun; Shen, Xiangling; Chen, Faju

2017-01-01

The dioecious relic Cercidiphyllum japonicum is one of two species of the sole genus Cercidiphyllum, with a tight inflorescence lacking an apparent perianth structure. In addition, its systematic place has been much debated and, so far researches have mainly focused on its morphology and chloroplast genes. In our investigation, we identified 10 floral organ identity genes, including four A-class, three B-class, two C-class and one D-class. Phylogenetic analyses showed that all ten genes are grouped with Saxifragales plants, which confirmed the phylogenetic place of C. japonicum. Expression patterns of those genes were examined by quantitative reverse transcriptase PCR, with some variations that did not completely coincide with the ABCDE model, suggesting some subfunctionalization. As well, our research supported the idea that thebract actually is perianth according to our morphological and molecular analyses in Cercidiphyllum japonicum. PMID:28562649

Convergent evolution of heat-inducibility during subfunctionalization of the Hsp70 gene family

PubMed Central

2013-01-01

Background Heat-shock proteins of the 70 kDa family (Hsp70s) are essential chaperones required for key cellular functions. In eukaryotes, four subfamilies can be distinguished according to their function and localisation in different cellular compartments: cytosol, endoplasmic reticulum, mitochondria and chloroplasts. Generally, multiple cytosol-type Hsp70s can be found in metazoans that show either constitutive expression and/or stress-inducibility, arguing for the evolution of different tasks and functions. Information about the hsp70 copy number and diversity in microbial eukaryotes is, however, scarce, and detailed knowledge about the differential gene expression in most protists is lacking. Therefore, we have characterised the Hsp70 gene family of Paramecium caudatum to gain insight into the evolution and differential heat stress response of the distinct family members in protists and to investigate the diversification of eukaryotic hsp70s focusing on the evolution of heat-inducibility. Results Eleven putative hsp70 genes could be detected in P. caudatum comprising homologs of three major Hsp70-subfamilies. Phylogenetic analyses revealed five evolutionarily distinct Hsp70-groups, each with a closer relationship to orthologous sequences of Paramecium tetraurelia than to another P. caudatum Hsp70-group. These highly diverse, paralogous groups resulted from duplications preceding Paramecium speciation, underwent divergent evolution and were subject to purifying selection. Heat-shock treatments were performed to test for differential expression patterns among the five Hsp70-groups as well as for a functional conservation within Paramecium. These treatments induced exceptionally high mRNA up-regulations in one cytosolic group with a low basal expression, indicative for the major heat inducible hsp70s. All other groups showed comparatively high basal expression levels and moderate heat-inducibility, signifying constitutively expressed genes. Comparative EST analyses for P. tetraurelia hsp70s unveiled a corresponding expression pattern, which supports a functionally conserved evolution of the Hsp70 gene family in Paramecium. Conclusions Our analyses suggest an independent evolution of the heat-inducible cytosol-type hsp70s in Paramecium and in its close relative Tetrahymena, as well as within higher eukaryotes. This result indicates convergent evolution during hsp70 subfunctionalization and implies that heat-inducibility evolved several times during the course of eukaryotic evolution. PMID:23433225

Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling

PubMed Central

Morin, Ryan D.; Chang, Elbert; Petrescu, Anca; Liao, Nancy; Griffith, Malachi; Kirkpatrick, Robert; Butterfield, Yaron S.; Young, Alice C.; Stott, Jeffrey; Barber, Sarah; Babakaiff, Ryan; Dickson, Mark C.; Matsuo, Corey; Wong, David; Yang, George S.; Smailus, Duane E.; Wetherby, Keith D.; Kwong, Peggy N.; Grimwood, Jane; Brinkley, Charles P.; Brown-John, Mabel; Reddix-Dugue, Natalie D.; Mayo, Michael; Schmutz, Jeremy; Beland, Jaclyn; Park, Morgan; Gibson, Susan; Olson, Teika; Bouffard, Gerard G.; Tsai, Miranda; Featherstone, Ruth; Chand, Steve; Siddiqui, Asim S.; Jang, Wonhee; Lee, Ed; Klein, Steven L.; Blakesley, Robert W.; Zeeberg, Barry R.; Narasimhan, Sudarshan; Weinstein, John N.; Pennacchio, Christa Prange; Myers, Richard M.; Green, Eric D.; Wagner, Lukas; Gerhard, Daniela S.; Marra, Marco A.; Jones, Steven J.M.; Holt, Robert A.

2006-01-01

Sequencing of full-insert clones from full-length cDNA libraries from both Xenopus laevis and Xenopus tropicalis has been ongoing as part of the Xenopus Gene Collection Initiative. Here we present 10,967 full ORF verified cDNA clones (8049 from X. laevis and 2918 from X. tropicalis) as a community resource. Because the genome of X. laevis, but not X. tropicalis, has undergone allotetraploidization, comparison of coding sequences from these two clawed (pipid) frogs provides a unique angle for exploring the molecular evolution of duplicate genes. Within our clone set, we have identified 445 gene trios, each comprised of an allotetraploidization-derived X. laevis gene pair and their shared X. tropicalis ortholog. Pairwise dN/dS, comparisons within trios show strong evidence for purifying selection acting on all three members. However, dN/dS ratios between X. laevis gene pairs are elevated relative to their X. tropicalis ortholog. This difference is highly significant and indicates an overall relaxation of selective pressures on duplicated gene pairs. We have found that the paralogs that have been lost since the tetraploidization event are enriched for several molecular functions, but have found no such enrichment in the extant paralogs. Approximately 14% of the paralogous pairs analyzed here also show differential expression indicative of subfunctionalization. PMID:16672307

Genome-wide analysis of the Dof transcription factor gene family reveals soybean-specific duplicable and functional characteristics.

PubMed

Guo, Yong; Qiu, Li-Juan

2013-01-01

The Dof domain protein family is a classic plant-specific zinc-finger transcription factor family involved in a variety of biological processes. There is great diversity in the number of Dof genes in different plants. However, there are only very limited reports on the characterization of Dof transcription factors in soybean (Glycine max). In the present study, 78 putative Dof genes were identified from the whole-genome sequence of soybean. The predicted GmDof genes were non-randomly distributed within and across 19 out of 20 chromosomes and 97.4% (38 pairs) were preferentially retained duplicate paralogous genes located in duplicated regions of the genome. Soybean-specific segmental duplications contributed significantly to the expansion of the soybean Dof gene family. These Dof proteins were phylogenetically clustered into nine distinct subgroups among which the gene structure and motif compositions were considerably conserved. Comparative phylogenetic analysis of these Dof proteins revealed four major groups, similar to those reported for Arabidopsis and rice. Most of the GmDofs showed specific expression patterns based on RNA-seq data analyses. The expression patterns of some duplicate genes were partially redundant while others showed functional diversity, suggesting the occurrence of sub-functionalization during subsequent evolution. Comprehensive expression profile analysis also provided insights into the soybean-specific functional divergence among members of the Dof gene family. Cis-regulatory element analysis of these GmDof genes suggested diverse functions associated with different processes. Taken together, our results provide useful information for the functional characterization of soybean Dof genes by combining phylogenetic analysis with global gene-expression profiling.

Extending the family table: insights into the FGF superfamily from beyond vertebrates

PubMed Central

2014-01-01

Since the discovery of Fibroblast Growth Factors much focus has been placed on elucidating the roles for each vertebrate FGF ligand, receptor, and regulating molecules in the context of vertebrate development, human disorders and cancer. Studies in human, mouse, Xenopus, chick, and zebrafish have gone a long way to help us understand [AS1]which FGFs are involved in which processes. However, in recent years, as more genomes are sequenced, more information is becoming available from many non-vertebrate models and a more complete picture of the FGF superfamily as a whole is emerging. In some cases less redundancy in the FGF signaling system in invertebrate models may allow for more mechanistic insights. Studies in cnidaria have highlighted how ancient FGF signaling is, and helped provide insight into the evolution of the FGF gene family. Work in C. elegans has shown that different splice forms can be used for functional specificity in invertebrate FGF signaling. Comparing FGFs from Ciona to those in vertebrates and FGFs from Tribolium to Drosophila reveals some important clues as to the process of gene loss, duplication and subfunctionalization of FGFs throughout evolution. Finally, comparing all members of the FGF ligand superfamily reveals variability in many properties, which may point to a feature of FGFs as being highly adaptable with regards to protein structure and mechanism. Further studies on FGF signaling outside of vertebrates is likely to complement work in vertebrates by contributing many insights to the FGF field as a whole and providing unexpected information that could be used for medical applications. PMID:20860061

Special trends in CBF and DREB2 groups in Eucalyptus gunnii vs Eucalyptus grandis suggest that CBF are master players in the trade-off between growth and stress resistance.

PubMed

Nguyen, Hong C; Cao, Phi B; San Clemente, Hélène; Ployet, Raphaël; Mounet, Fabien; Ladouce, Nathalie; Harvengt, Luc; Marque, Christiane; Teulieres, Chantal

2017-04-01

Annotation of the Eucalyptus grandis genome showed a large amplification of the dehydration-responsive element binding 1/C-repeat binding factor (DREB1/CBF) group without recent DREB2 gene duplication compared with other plant species. The present annotation of the CBF and DREB2 genes from a draft of the Eucalyptus gunnii genome sequence reveals at least one additional CBF copy in the E. gunnii genome compared with E. grandis, suggesting that this group is still evolving, unlike the DREB2 group. This study aims to investigate the redundancy/neo- or sub-functionalization of the duplicates and the relative involvement of the two groups in abiotic stress responses in both E. grandis and E. gunnii (lower growth but higher cold resistance). A comprehensive transcriptional analysis using high-throughput quantitative real-time polymerase chain reaction (qRT-PCR) was performed on leaves, stems and roots from the two Eucalyptus species after cold, heat or drought treatment. A large CBF cluster accounted for most of the cold response in all the organs, whereas heat and drought responses mainly involved a small CBF cluster and the DREB2 genes. In addition, CBF putative target genes, known to be involved in plant tolerance and development, were found to be cold-regulated. The higher transcript amounts of both the CBF and target genes in the cold tolerant E. gunnii contrasted with the higher CBF induction rates in the fast growing E. grandis. Altogether, the present results, in agreement with previous data about Eucalyptus transgenic lines over-expressing CBF, suggest that these factors, which promote both stress protection and growth limitation, participate in the trade-off between growth and resistance in this woody species. © 2016 Scandinavian Plant Physiology Society.

Diversification and evolution of the SDG gene family in Brassica rapa after the whole genome triplication.

PubMed

Dong, Heng; Liu, Dandan; Han, Tianyu; Zhao, Yuxue; Sun, Ji; Lin, Sue; Cao, Jiashu; Chen, Zhong-Hua; Huang, Li

2015-11-24

Histone lysine methylation, controlled by the SET Domain Group (SDG) gene family, is part of the histone code that regulates chromatin function and epigenetic control of gene expression. Analyzing the SDG gene family in Brassica rapa for their gene structure, domain architecture, subcellular localization, rate of molecular evolution and gene expression pattern revealed common occurrences of subfunctionalization and neofunctionalization in BrSDGs. In comparison with Arabidopsis thaliana, the BrSDG gene family was found to be more divergent than AtSDGs, which might partly explain the rich variety of morphotypes in B. rapa. In addition, a new evolutionary pattern of the four main groups of SDGs was presented, in which the Trx group and the SUVR subgroup evolved faster than the E(z), Ash groups and the SUVH subgroup. These differences in evolutionary rate among the four main groups of SDGs are perhaps due to the complexity and variability of the regions that bind with biomacromolecules, which guide SDGs to their target loci.

Diversification and evolution of the SDG gene family in Brassica rapa after the whole genome triplication

PubMed Central

Dong, Heng; Liu, Dandan; Han, Tianyu; Zhao, Yuxue; Sun, Ji; Lin, Sue; Cao, Jiashu; Chen, Zhong-Hua; Huang, Li

2015-01-01

Histone lysine methylation, controlled by the SET Domain Group (SDG) gene family, is part of the histone code that regulates chromatin function and epigenetic control of gene expression. Analyzing the SDG gene family in Brassica rapa for their gene structure, domain architecture, subcellular localization, rate of molecular evolution and gene expression pattern revealed common occurrences of subfunctionalization and neofunctionalization in BrSDGs. In comparison with Arabidopsis thaliana, the BrSDG gene family was found to be more divergent than AtSDGs, which might partly explain the rich variety of morphotypes in B. rapa. In addition, a new evolutionary pattern of the four main groups of SDGs was presented, in which the Trx group and the SUVR subgroup evolved faster than the E(z), Ash groups and the SUVH subgroup. These differences in evolutionary rate among the four main groups of SDGs are perhaps due to the complexity and variability of the regions that bind with biomacromolecules, which guide SDGs to their target loci. PMID:26596461

Origin and functional diversification of an amphibian defense peptide arsenal.

PubMed

Roelants, Kim; Fry, Bryan G; Ye, Lumeng; Stijlemans, Benoit; Brys, Lea; Kok, Philippe; Clynen, Elke; Schoofs, Liliane; Cornelis, Pierre; Bossuyt, Franky

2013-01-01

The skin secretion of many amphibians contains an arsenal of bioactive molecules, including hormone-like peptides (HLPs) acting as defense toxins against predators, and antimicrobial peptides (AMPs) providing protection against infectious microorganisms. Several amphibian taxa seem to have independently acquired the genes to produce skin-secreted peptide arsenals, but it remains unknown how these originated from a non-defensive ancestral gene and evolved diverse defense functions against predators and pathogens. We conducted transcriptome, genome, peptidome and phylogenetic analyses to chart the full gene repertoire underlying the defense peptide arsenal of the frog Silurana tropicalis and reconstruct its evolutionary history. Our study uncovers a cluster of 13 transcriptionally active genes, together encoding up to 19 peptides, including diverse HLP homologues and AMPs. This gene cluster arose from a duplicated gastrointestinal hormone gene that attained a HLP-like defense function after major remodeling of its promoter region. Instead, new defense functions, including antimicrobial activity, arose by mutation of the precursor proteins, resulting in the proteolytic processing of secondary peptides alongside the original ones. Although gene duplication did not trigger functional innovation, it may have subsequently facilitated the convergent loss of the original function in multiple gene lineages (subfunctionalization), completing their transformation from HLP gene to AMP gene. The processing of multiple peptides from a single precursor entails a mechanism through which peptide-encoding genes may establish new functions without the need for gene duplication to avoid adaptive conflicts with older ones.

Diversity and population-genetic properties of copy number variations and multicopy genes in cattle

PubMed Central

Bickhart, Derek M.; Xu, Lingyang; Hutchison, Jana L.; Cole, John B.; Null, Daniel J.; Schroeder, Steven G.; Song, Jiuzhou; Garcia, Jose Fernando; Sonstegard, Tad S.; Van Tassell, Curtis P.; Schnabel, Robert D.; Taylor, Jeremy F.; Lewin, Harris A.; Liu, George E.

2016-01-01

The diversity and population genetics of copy number variation (CNV) in domesticated animals are not well understood. In this study, we analysed 75 genomes of major taurine and indicine cattle breeds (including Angus, Brahman, Gir, Holstein, Jersey, Limousin, Nelore, and Romagnola), sequenced to 11-fold coverage to identify 1,853 non-redundant CNV regions. Supported by high validation rates in array comparative genomic hybridization (CGH) and qPCR experiments, these CNV regions accounted for 3.1% (87.5 Mb) of the cattle reference genome, representing a significant increase over previous estimates of the area of the genome that is copy number variable (∼2%). Further population genetics and evolutionary genomics analyses based on these CNVs revealed the population structures of the cattle taurine and indicine breeds and uncovered potential diversely selected CNVs near important functional genes, including AOX1, ASZ1, GAT, GLYAT, and KRTAP9-1. Additionally, 121 CNV gene regions were found to be either breed specific or differentially variable across breeds, such as RICTOR in dairy breeds and PNPLA3 in beef breeds. In contrast, clusters of the PRP and PAG genes were found to be duplicated in all sequenced animals, suggesting that subfunctionalization, neofunctionalization, or overdominance play roles in diversifying those fertility-related genes. These CNV results provide a new glimpse into the diverse selection histories of cattle breeds and a basis for correlating structural variation with complex traits in the future. PMID:27085184

Diversification, evolution and sub-functionalization of 70kDa heat-shock proteins in two sister species of antarctic krill: differences in thermal habitats, responses and implications under climate change.

PubMed

Cascella, Kévin; Jollivet, Didier; Papot, Claire; Léger, Nelly; Corre, Erwan; Ravaux, Juliette; Clark, Melody S; Toullec, Jean-Yves

2015-01-01

A comparative thermal tolerance study was undertaken on two sister species of Euphausiids (Antarctic krills) Euphausia superba and Euphausia crystallorophias. Both are essential components of the Southern Ocean ecosystem, but occupy distinct environmental geographical locations with slightly different temperature regimes. They therefore provide a useful model system for the investigation of adaptations to thermal tolerance. Initial CTmax studies showed that E. superba was slightly more thermotolerant than E. crystallorophias. Five Hsp70 mRNAs were characterized from the RNAseq data of both species and subsequent expression kinetics studies revealed notable differences in induction of each of the 5 orthologues between the two species, with E. crystallorophias reacting more rapidly than E. superba. Furthermore, analyses conducted to estimate the evolutionary rates and selection strengths acting on each gene tended to support the hypothesis that diversifying selection has contributed to the diversification of this gene family, and led to the selective relaxation on the inducible C form with its possible loss of function in the two krill species. The sensitivity of the epipelagic species E. crystallorophias to temperature variations and/or its adaptation to cold is enhanced when compared with its sister species, E. superba. These results indicate that ice krill could be the first of the two species to be impacted by the warming of coastal waters of the Austral ocean in the coming years due to climate change.

The house spider genome reveals an ancient whole-genome duplication during arachnid evolution.

PubMed

Schwager, Evelyn E; Sharma, Prashant P; Clarke, Thomas; Leite, Daniel J; Wierschin, Torsten; Pechmann, Matthias; Akiyama-Oda, Yasuko; Esposito, Lauren; Bechsgaard, Jesper; Bilde, Trine; Buffry, Alexandra D; Chao, Hsu; Dinh, Huyen; Doddapaneni, HarshaVardhan; Dugan, Shannon; Eibner, Cornelius; Extavour, Cassandra G; Funch, Peter; Garb, Jessica; Gonzalez, Luis B; Gonzalez, Vanessa L; Griffiths-Jones, Sam; Han, Yi; Hayashi, Cheryl; Hilbrant, Maarten; Hughes, Daniel S T; Janssen, Ralf; Lee, Sandra L; Maeso, Ignacio; Murali, Shwetha C; Muzny, Donna M; Nunes da Fonseca, Rodrigo; Paese, Christian L B; Qu, Jiaxin; Ronshaugen, Matthew; Schomburg, Christoph; Schönauer, Anna; Stollewerk, Angelika; Torres-Oliva, Montserrat; Turetzek, Natascha; Vanthournout, Bram; Werren, John H; Wolff, Carsten; Worley, Kim C; Bucher, Gregor; Gibbs, Richard A; Coddington, Jonathan; Oda, Hiroki; Stanke, Mario; Ayoub, Nadia A; Prpic, Nikola-Michael; Flot, Jean-François; Posnien, Nico; Richards, Stephen; McGregor, Alistair P

2017-07-31

The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum. We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication. Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes.

Cone arrestin confers cone vision of high temporal resolution in zebrafish larvae.

PubMed

Renninger, Sabine L; Gesemann, Matthias; Neuhauss, Stephan C F

2011-02-01

Vision of high temporal resolution depends on careful regulation of photoresponse kinetics, beginning with the lifetime of activated photopigment. The activity of rhodopsin is quenched by high-affinity binding of arrestin to photoexcited phosphorylated photopigment, which effectively terminates the visual transduction cascade. This regulation mechanism is well established for rod photoreceptors, yet its role for cone vision is still controversial. In this study we therefore analyzed arrestin function in the cone-dominated vision of larval zebrafish. For both rod (arrS ) and cone (arr3 ) arrestin we isolated two paralogs, each expressed in the respective subset of photoreceptors. Labeling with paralog-specific antibodies revealed subfunctionalized expression of Arr3a in M- and L-cones, and Arr3b in S- and UV-cones. The inactivation of arr3a by morpholino knockdown technology resulted in a severe delay in photoresponse recovery which, under bright light conditions, was rate-limiting. Comparison to opsin phosphorylation-deficient animals confirmed the role of cone arrestin in late cone response recovery. Arr3a activity partially overlapped with the function of the cone-specific kinase Grk7a involved in initial response recovery. Behavioral measurements further revealed Arr3a deficiency to be sufficient to reduce temporal contrast sensitivity, providing evidence for the importance of arrestin in cone vision of high temporal resolution. © 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

Origin and Functional Diversification of an Amphibian Defense Peptide Arsenal

PubMed Central

Roelants, Kim; Fry, Bryan G.; Ye, Lumeng; Stijlemans, Benoit; Brys, Lea; Kok, Philippe; Clynen, Elke; Schoofs, Liliane; Cornelis, Pierre; Bossuyt, Franky

2013-01-01

The skin secretion of many amphibians contains an arsenal of bioactive molecules, including hormone-like peptides (HLPs) acting as defense toxins against predators, and antimicrobial peptides (AMPs) providing protection against infectious microorganisms. Several amphibian taxa seem to have independently acquired the genes to produce skin-secreted peptide arsenals, but it remains unknown how these originated from a non-defensive ancestral gene and evolved diverse defense functions against predators and pathogens. We conducted transcriptome, genome, peptidome and phylogenetic analyses to chart the full gene repertoire underlying the defense peptide arsenal of the frog Silurana tropicalis and reconstruct its evolutionary history. Our study uncovers a cluster of 13 transcriptionally active genes, together encoding up to 19 peptides, including diverse HLP homologues and AMPs. This gene cluster arose from a duplicated gastrointestinal hormone gene that attained a HLP-like defense function after major remodeling of its promoter region. Instead, new defense functions, including antimicrobial activity, arose by mutation of the precursor proteins, resulting in the proteolytic processing of secondary peptides alongside the original ones. Although gene duplication did not trigger functional innovation, it may have subsequently facilitated the convergent loss of the original function in multiple gene lineages (subfunctionalization), completing their transformation from HLP gene to AMP gene. The processing of multiple peptides from a single precursor entails a mechanism through which peptide-encoding genes may establish new functions without the need for gene duplication to avoid adaptive conflicts with older ones. PMID:23935531

Partial redundancy and functional specialization of E-class SEPALLATA genes in an early-diverging eudicot.

PubMed

Soza, Valerie L; Snelson, Corey D; Hewett Hazelton, Kristen D; Di Stilio, Verónica S

2016-11-01

Plant MADS-box genes have duplicated extensively, allegedly contributing to the immense diversity of floral form in angiosperms. In Arabidopsis thaliana (a core eudicot model plant), four SEPALLATA (SEP) genes comprise the E-class from the extended ABCE model of flower development. They are redundantly involved in the development of the four types of floral organs (sepals, petals, stamens and carpels) and in floral meristem determinacy. E-class genes have been examined in other core eudicots and monocots, but have been less investigated in non-core eudicots. Our goal was to functionally characterize the E-class genes in the early-diverging eudicot Thalictrum thalictroides (Ranunculaceae), whose flowers are apetalous. We identified four SEP orthologs, which when placed in a phylogenetic context, resulted from a major gene duplication event before the origin of angiosperms and a subsequent duplication at the origin of the Ranunculales. We used Virus-Induced Gene Silencing (VIGS) to down-regulate the three expressed paralogs individually and in combination to investigate their function and to determine the degree of conservation versus divergence of this important plant transcription factor. All loci were partially redundant in sepal and stamen identity and in promoting petaloidy of sepals, yet the SEP3 ortholog had a more pronounced role in carpel identity and development. The two other paralogs appear to have subfunctionalized in their cadastral roles to keep the boundaries between either sepal and stamen zones or stamen and carpel zones. Double knockdowns had enhanced phenotypes and the triple knockdown had an even more severe phenotype that included partial to complete homeotic conversion of stamens and carpels to sepaloid organs and green sepals, highlighting a role of E-class genes in petaloidy of sepals in this species. While no floral meristem determinacy defects were observed, this could be due to residual amounts of gene expression in the VIGS experiments being sufficient to perform this function or to the masking role of a redundant gene. Copyright © 2016 Elsevier Inc. All rights reserved.

Identification and expression analysis of the SQUAMOSA promoter-binding protein (SBP)-box gene family in Prunus mume.

PubMed

Xu, Zongda; Sun, Lidan; Zhou, Yuzhen; Yang, Weiru; Cheng, Tangren; Wang, Jia; Zhang, Qixiang

2015-10-01

SQUAMOSA promoter-binding protein (SBP)-box family genes encode plant-specific transcription factors that play crucial roles in plant development, especially flower and fruit development. However, little information on this gene family is available for Prunus mume, an ornamental and fruit tree widely cultivated in East Asia. To explore the evolution of SBP-box genes in Prunus and explore their functions in flower and fruit development, we performed a genome-wide analysis of the SBP-box gene family in P. mume. Fifteen SBP-box genes were identified, and 11 of them contained an miR156 target site. Phylogenetic and comprehensive bioinformatics analyses revealed that different groups of SBP-box genes have undergone different evolutionary processes and varied in their length, structure, and motif composition. Purifying selection has been the main selective constraint on both paralogous and orthologous SBP-box genes. In addition, the sequences of orthologous SBP-box genes did not diverge widely after the split of P. mume and Prunus persica. Expression analysis of P. mume SBP-box genes revealed their diverse spatiotemporal expression patterns. Three duplicated SBP-box genes may have undergone subfunctionalization in Prunus. Most of the SBP-box genes showed high transcript levels in flower buds and young fruit. The four miR156-nontargeted genes were upregulated during fruit ripening. Together, these results provide information about the evolution of SBP-box genes in Prunus. The expression analysis lays the foundation for further research on the functions of SBP-box genes in P. mume and other Prunus species, especially during flower and fruit development.

Genome Wide Identification, Evolutionary, and Expression Analysis of VQ Genes from Two Pyrus Species.

PubMed

Cao, Yunpeng; Meng, Dandan; Abdullah, Muhammad; Jin, Qing; Lin, Yi; Cai, Yongping

2018-04-23

The VQ motif-containing gene, a member of the plant-specific genes, is involved in the plant developmental process and various stress responses. The VQ motif-containing gene family has been studied in several plants, such as rice ( Oryza sativa ), maize ( Zea mays ), and Arabidopsis ( Arabidopsis thaliana ). However, no systematic study has been performed in Pyrus species, which have important economic value. In our study, we identified 41 and 28 VQ motif-containing genes in Pyrus bretschneideri and Pyrus communis , respectively. Phylogenetic trees were calculated using A. thaliana and O. sativa VQ motif-containing genes as a template, allowing us to categorize these genes into nine subfamilies. Thirty-two and eight paralogous of VQ motif-containing genes were found in P. bretschneideri and P. communis , respectively, showing that the VQ motif-containing genes had a more remarkable expansion in P. bretschneideri than in P. communis . A total of 31 orthologous pairs were identified from the P. bretschneideri and P. communis VQ motif-containing genes. Additionally, among the paralogs, we found that these duplication gene pairs probably derived from segmental duplication/whole-genome duplication (WGD) events in the genomes of P. bretschneideri and P. communis , respectively. The gene expression profiles in both P. bretschneideri and P. communis fruits suggested functional redundancy for some orthologous gene pairs derived from a common ancestry, and sub-functionalization or neo-functionalization for some of them. Our study provided the first systematic evolutionary analysis of the VQ motif-containing genes in Pyrus , and highlighted the diversification and duplication of VQ motif-containing genes in both P. bretschneideri and P. communis .

The circadian clock of teleost fish: a comparative analysis reveals distinct fates for duplicated genes.

PubMed

Toloza-Villalobos, Jessica; Arroyo, José Ignacio; Opazo, Juan C

2015-01-01

The circadian clock is a central oscillator that coordinates endogenous rhythms. Members of six gene families underlie the metabolic machinery of this system. Although this machinery appears to correspond to a highly conserved genetic system in metazoans, it has been recognized that vertebrates possess a more diverse gene inventory than that of non-vertebrates. This difference could have originated in the two successive rounds of whole-genome duplications that took place in the common ancestor of the group. Teleost fish underwent an extra event of whole-genome duplication, which is thought to have provided an abundance of raw genetic material for the biological innovations that facilitated the radiation of the group. In this study, we assessed the relative contributions of whole-genome duplication and small-scale gene duplication to generate the repertoire of genes associated with the circadian clock of teleost fish. To achieve this goal, we annotated genes from six gene families associated with the circadian clock in eight teleost fish species, and we reconstructed their evolutionary history by inferring phylogenetic relationships. Our comparative analysis indicated that teleost species possess a variable repertoire of genes related to the circadian clock gene families and that the actual diversity of these genes has been shaped by a variety of phenomena, such as the complete deletion of ohnologs, the differential retention of genes, and lineage-specific gene duplications. From a functional perspective, the subfunctionalization of two ohnolog genes (PER1a and PER1b) in zebrafish highlights the power of whole-genome duplications to generate biological diversity.

Evolution of Chemical Diversity in Echinocandin Lipopeptide Antifungal Metabolites

PubMed Central

Yue, Qun; Chen, Li; Zhang, Xiaoling; Li, Kuan; Sun, Jingzu; Liu, Xingzhong

2015-01-01

The echinocandins are a class of antifungal drugs that includes caspofungin, micafungin, and anidulafungin. Gene clusters encoding most of the structural complexity of the echinocandins provided a framework for hypotheses about the evolutionary history and chemical logic of echinocandin biosynthesis. Gene orthologs among echinocandin-producing fungi were identified. Pathway genes, including the nonribosomal peptide synthetases (NRPSs), were analyzed phylogenetically to address the hypothesis that these pathways represent descent from a common ancestor. The clusters share cooperative gene contents and linkages among the different strains. Individual pathway genes analyzed in the context of similar genes formed unique echinocandin-exclusive phylogenetic lineages. The echinocandin NRPSs, along with the NRPS from the inp gene cluster in Aspergillus nidulans and its orthologs, comprise a novel lineage among fungal NRPSs. NRPS adenylation domains from different species exhibited a one-to-one correspondence between modules and amino acid specificity that is consistent with models of tandem duplication and subfunctionalization. Pathway gene trees and Ascomycota phylogenies are congruent and consistent with the hypothesis that the echinocandin gene clusters have a common origin. The disjunct Eurotiomycete-Leotiomycete distribution appears to be consistent with a scenario of vertical descent accompanied by incomplete lineage sorting and loss of the clusters from most lineages of the Ascomycota. We present evidence for a single evolutionary origin of the echinocandin family of gene clusters and a progression of structural diversification in two fungal classes that diverged approximately 290 to 390 million years ago. Lineage-specific gene cluster evolution driven by selection of new chemotypes contributed to diversification of the molecular functionalities. PMID:26024901

Prevalent Role of Gene Features in Determining Evolutionary Fates of Whole-Genome Duplication Duplicated Genes in Flowering Plants1[W][OA

PubMed Central

Jiang, Wen-kai; Liu, Yun-long; Xia, En-hua; Gao, Li-zhi

2013-01-01

The evolution of genes and genomes after polyploidization has been the subject of extensive studies in evolutionary biology and plant sciences. While a significant number of duplicated genes are rapidly removed during a process called fractionation, which operates after the whole-genome duplication (WGD), another considerable number of genes are retained preferentially, leading to the phenomenon of biased gene retention. However, the evolutionary mechanisms underlying gene retention after WGD remain largely unknown. Through genome-wide analyses of sequence and functional data, we comprehensively investigated the relationships between gene features and the retention probability of duplicated genes after WGDs in six plant genomes, Arabidopsis (Arabidopsis thaliana), poplar (Populus trichocarpa), soybean (Glycine max), rice (Oryza sativa), sorghum (Sorghum bicolor), and maize (Zea mays). The results showed that multiple gene features were correlated with the probability of gene retention. Using a logistic regression model based on principal component analysis, we resolved evolutionary rate, structural complexity, and GC3 content as the three major contributors to gene retention. Cluster analysis of these features further classified retained genes into three distinct groups in terms of gene features and evolutionary behaviors. Type I genes are more prone to be selected by dosage balance; type II genes are possibly subject to subfunctionalization; and type III genes may serve as potential targets for neofunctionalization. This study highlights that gene features are able to act jointly as primary forces when determining the retention and evolution of WGD-derived duplicated genes in flowering plants. These findings thus may help to provide a resolution to the debate on different evolutionary models of gene fates after WGDs. PMID:23396833

Development of the central nervous system in the larvacean Oikopleura dioica and the evolution of the chordate brain.

PubMed

Cañestro, Cristian; Bassham, Susan; Postlethwait, John

2005-09-15

In non-vertebrate chordates, central nervous system (CNS) development has been studied in only two taxa, the Cephalochordata and a single Class (Ascidiacea) of the morphologically diverse Urochordata. To understand development and molecular regionalization of the brain in a different deeply diverging chordate clade, we isolated and determined the expression patterns of orthologs of vertebrate CNS markers (otxa, otxb, otxc, pax6, pax2/5/8a, pax2/5/8b, engrailed, and hox1) in Oikopleura dioica (Subphylum Urochordata, Class Larvacea). The three Oikopleura otx genes are expressed similarly to vertebrate Otx paralogs, demonstrating that trans-homologs converged on similar evolutionary outcomes by independent neo- or subfunctionalization processes during the evolution of the two taxa. This work revealed that the Oikopleura CNS possesses homologs of the vertebrate forebrain, hindbrain, and spinal cord, but not the midbrain. Comparing larvacean gene expression patterns to published results in ascidians disclosed important developmental differences and similarities that suggest mechanisms of development likely present in their last common ancestor. In contrast to ascidians, the lack of a radical reorganization of the CNS as larvaceans become adults allows us to relate embryonic gene expression patterns to three subdivisions of the adult anterior brain. Our study of the Oikopleura brain provides new insights into chordate CNS evolution: first, the absence of midbrain is a urochordate synapomorphy and not a peculiarity of ascidians, perhaps resulting from their drastic CNS metamorphosis; second, there is no convincing evidence for a homolog of a midbrain-hindbrain boundary (MHB) organizer in urochordates; and third, the expression pattern of "MHB-genes" in the urochordate hindbrain suggests that they function in the development of specific neurons rather than in an MHB organizer.

New insights on the evolution of Leafy cotyledon1 (LEC1) type genes in vascular plants.

PubMed

Cagliari, Alexandro; Turchetto-Zolet, Andreia Carina; Korbes, Ana Paula; Maraschin, Felipe Dos Santos; Margis, Rogerio; Margis-Pinheiro, Marcia

2014-01-01

NF-Y is a conserved oligomeric transcription factor found in all eukaryotes. In plants, this regulator evolved with a broad diversification of the genes coding for its three subunits (NF-YA, NF-YB and NF-YC). The NF-YB members can be divided into Leafy Cotyledon1 (LEC1) and non-LEC1 types. Here we presented a comparative genomic study using phylogenetic analyses to validate an evolutionary model for the origin of LEC-type genes in plants and their emergence from non-LEC1-type genes. We identified LEC1-type members in all vascular plant genomes, but not in amoebozoa, algae, fungi, metazoa and non-vascular plant representatives, which present exclusively non-LEC1-type genes as constituents of their NF-YB subunits. The non-synonymous to synonymous nucleotide substitution rates (Ka/Ks) between LEC1 and non-LEC1-type genes indicate the presence of positive selection acting on LEC1-type members to the fixation of LEC1-specific amino acid residues. The phylogenetic analyses demonstrated that plant LEC1-type genes are evolutionary divergent from the non-LEC1-type genes of plants, fungi, amoebozoa, algae and animals. Our results point to a scenario in which LEC1-type genes have originated in vascular plants after gene expansion in plants. We suggest that processes of neofunctionalization and/or subfunctionalization were responsible for the emergence of a versatile role for LEC1-type genes in vascular plants, especially in seed plants. LEC1-type genes besides being phylogenetic divergent also present different expression profile when compared with non-LEC1-type genes. Altogether, our data provide new insights about the LEC1 and non-LEC1 evolutionary relationship during the vascular plant evolution. Copyright © 2014 Elsevier Inc. All rights reserved.

Evolutionary Insights into Taste Perception of the Invasive Pest Drosophila suzukii.

PubMed

Crava, Cristina M; Ramasamy, Sukanya; Ometto, Lino; Anfora, Gianfranco; Rota-Stabelli, Omar

2016-12-07

Chemosensory perception allows insects to interact with the environment by perceiving odorant or tastant molecules; genes encoding chemoreceptors are the molecular interface between the environment and the insect, and play a central role in mediating its chemosensory behavior. Here, we explore how the evolution of these genes in the emerging pest Drosophila suzukii correlates with the peculiar ecology of this species. We annotated approximately 130 genes coding for gustatory receptors (GRs) and divergent ionotropic receptors (dIRs) in D. suzukii and in its close relative D. biarmipes We then analyzed the evolution, in terms of size, of each gene family as well of the molecular evolution of the genes in a 14 Drosophila species phylogenetic framework. We show that the overall evolution of GRs parallels that of dIRs not only in D. suzukii, but also in all other analyzed Drosophila Our results reveal an unprecedented burst of gene family size in the lineage leading to the suzukii subgroup, as well as genomic changes that characterize D. suzukii, particularly duplications and strong signs of positive selection in the putative bitter-taste receptor GR59d. Expression studies of duplicate genes in D. suzukii support a spatio-temporal subfunctionalization of the duplicate isoforms. Our results suggest that D. suzukii is not characterized by gene loss, as observed in other specialist Drosophila species, but rather by a dramatic acceleration of gene gains, compatible with a highly generalist feeding behavior. Overall, our analyses provide candidate taste receptors specific for D. suzukii that may correlate with its specific behavior, and which may be tested in functional studies to ultimately enhance its control in the field. Copyright © 2016 Crava et al.

How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation

PubMed Central

Schroeder, Mark D.; Greer, Christina; Gaul, Ulrike

2011-01-01

The generation of metameric body plans is a key process in development. In Drosophila segmentation, periodicity is established rapidly through the complex transcriptional regulation of the pair-rule genes. The ‘primary’ pair-rule genes generate their 7-stripe expression through stripe-specific cis-regulatory elements controlled by the preceding non-periodic maternal and gap gene patterns, whereas ‘secondary’ pair-rule genes are thought to rely on 7-stripe elements that read off the already periodic primary pair-rule patterns. Using a combination of computational and experimental approaches, we have conducted a comprehensive systems-level examination of the regulatory architecture underlying pair-rule stripe formation. We find that runt (run), fushi tarazu (ftz) and odd skipped (odd) establish most of their pattern through stripe-specific elements, arguing for a reclassification of ftz and odd as primary pair-rule genes. In the case of run, we observe long-range cis-regulation across multiple intervening genes. The 7-stripe elements of run, ftz and odd are active concurrently with the stripe-specific elements, indicating that maternal/gap-mediated control and pair-rule gene cross-regulation are closely integrated. Stripe-specific elements fall into three distinct classes based on their principal repressive gap factor input; stripe positions along the gap gradients correlate with the strength of predicted input. The prevalence of cis-elements that generate two stripes and their genomic organization suggest that single-stripe elements arose by splitting and subfunctionalization of ancestral dual-stripe elements. Overall, our study provides a greatly improved understanding of how periodic patterns are established in the Drosophila embryo. PMID:21693522

Molecular Evolution and Functional Diversification of Replication Protein A1 in Plants

PubMed Central

Aklilu, Behailu B.; Culligan, Kevin M.

2016-01-01

Replication protein A (RPA) is a heterotrimeric, single-stranded DNA binding complex required for eukaryotic DNA replication, repair, and recombination. RPA is composed of three subunits, RPA1, RPA2, and RPA3. In contrast to single RPA subunit genes generally found in animals and yeast, plants encode multiple paralogs of RPA subunits, suggesting subfunctionalization. Genetic analysis demonstrates that five Arabidopsis thaliana RPA1 paralogs (RPA1A to RPA1E) have unique and overlapping functions in DNA replication, repair, and meiosis. We hypothesize here that RPA1 subfunctionalities will be reflected in major structural and sequence differences among the paralogs. To address this, we analyzed amino acid and nucleotide sequences of RPA1 paralogs from 25 complete genomes representing a wide spectrum of plants and unicellular green algae. We find here that the plant RPA1 gene family is divided into three general groups termed RPA1A, RPA1B, and RPA1C, which likely arose from two progenitor groups in unicellular green algae. In the family Brassicaceae the RPA1B and RPA1C groups have further expanded to include two unique sub-functional paralogs RPA1D and RPA1E, respectively. In addition, RPA1 groups have unique domains, motifs, cis-elements, gene expression profiles, and pattern of conservation that are consistent with proposed functions in monocot and dicot species, including a novel C-terminal zinc-finger domain found only in plant RPA1C-like sequences. These results allow for improved prediction of RPA1 subunit functions in newly sequenced plant genomes, and potentially provide a unique molecular tool to improve classification of Brassicaceae species. PMID:26858742

Genome Wide Identification, Evolutionary, and Expression Analysis of VQ Genes from Two Pyrus Species

PubMed Central

Meng, Dandan; Abdullah, Muhammad; Jin, Qing; Lin, Yi; Cai, Yongping

2018-01-01

The VQ motif-containing gene, a member of the plant-specific genes, is involved in the plant developmental process and various stress responses. The VQ motif-containing gene family has been studied in several plants, such as rice (Oryza sativa), maize (Zea mays), and Arabidopsis (Arabidopsis thaliana). However, no systematic study has been performed in Pyrus species, which have important economic value. In our study, we identified 41 and 28 VQ motif-containing genes in Pyrus bretschneideri and Pyrus communis, respectively. Phylogenetic trees were calculated using A. thaliana and O. sativa VQ motif-containing genes as a template, allowing us to categorize these genes into nine subfamilies. Thirty-two and eight paralogous of VQ motif-containing genes were found in P. bretschneideri and P. communis, respectively, showing that the VQ motif-containing genes had a more remarkable expansion in P. bretschneideri than in P. communis. A total of 31 orthologous pairs were identified from the P. bretschneideri and P. communis VQ motif-containing genes. Additionally, among the paralogs, we found that these duplication gene pairs probably derived from segmental duplication/whole-genome duplication (WGD) events in the genomes of P. bretschneideri and P. communis, respectively. The gene expression profiles in both P. bretschneideri and P. communis fruits suggested functional redundancy for some orthologous gene pairs derived from a common ancestry, and sub-functionalization or neo-functionalization for some of them. Our study provided the first systematic evolutionary analysis of the VQ motif-containing genes in Pyrus, and highlighted the diversification and duplication of VQ motif-containing genes in both P. bretschneideri and P. communis. PMID:29690608

A Change in SHATTERPROOF Protein Lies at the Origin of a Fruit Morphological Novelty and a New Strategy for Seed Dispersal in Medicago Genus1[C][W

PubMed Central

Fourquin, Chloé; del Cerro, Carolina; Victoria, Filipe C.; Vialette-Guiraud, Aurélie; de Oliveira, Antonio C.; Ferrándiz, Cristina

2013-01-01

Angiosperms are the most diverse and numerous group of plants, and it is generally accepted that this evolutionary success owes in part to the diversity found in fruits, key for protecting the developing seeds and ensuring seed dispersal. Although studies on the molecular basis of morphological innovations are few, they all illustrate the central role played by transcription factors acting as developmental regulators. Here, we show that a small change in the protein sequence of a MADS-box transcription factor correlates with the origin of a highly modified fruit morphology and the change in seed dispersal strategies that occurred in Medicago, a genus belonging to the large legume family. This protein sequence modification alters the functional properties of the protein, affecting the affinities for other protein partners involved in high-order complexes. Our work illustrates that variation in coding regions can generate evolutionary novelties not based on gene duplication/subfunctionalization but by interactions in complex networks, contributing also to the current debate on the relative importance of changes in regulatory or coding regions of master regulators in generating morphological novelties. PMID:23640757

Wicked Problems in Special and Inclusive Education

ERIC Educational Resources Information Center

Armstrong, David

2017-01-01

This special paper provides a critical overview of wicked problems in special and inclusive education. Practically, this paper provides a strategic framework for future special issues in the "Journal of Special Educational Needs". Critical attention is also given to the concept of a wicked problem when applied to research in special and…

Manual for Special Education Nurses.

ERIC Educational Resources Information Center

Schnetter, Vicki A., Ed.

This manual aims (1) to provide a standard, well-referenced resource for Iowa special education nurses and (2) to provide direction and continuity for health services to pupils with special needs. The first chapter provides an overview of the special education nurse's role, including philosophy, definitions of assignments, levels of service, and…

Using Technology to Address Barriers in Rural Special Education for Students with Autism: A Do-It-Yourself Guide

ERIC Educational Resources Information Center

McKissick, Bethany R.; Diegelmann, Karen M.; Parker, Sarah

2017-01-01

Providing high-quality special education services in rural settings has a variety of challenges such as geographic isolation and a lack of resources. One particularly challenging aspect of rural special education is providing general curriculum access. Computer-assisted instruction is one way to provide high-quality specialized instruction that…

What Do Employers Ask for in Advertisements for Special Education Positions?

ERIC Educational Resources Information Center

Stephenson, Jennifer; Carter, Mark

2014-01-01

Although qualified special educators are more likely to provide effective teaching for students with disabilities and special education needs, it seems many teachers in special education and support positions are not qualified for this role. The study reported here provided analysis of 219 job advertisements for special education positions in…

48 CFR 1545.309 - Providing Government production and research property under special restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... improvements necessary for installing special tooling, special test equipment, or plant equipment, shall not be... production and research property under special restrictions. 1545.309 Section 1545.309 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Providing...

Office of Special Services Annual Report, FY 1999.

ERIC Educational Resources Information Center

Front Range Community Coll., Westminster, CO.

This report lists support services provided by the Westminster Campus Special Services Department to the Westminster, Brighton, Longmont, and North Boulder Campuses. The Special Services Department provides disability services, including interpreting for the deaf, tutoring, gender equity support, and special populations transition support.…

Metallothionein Gene Family in the Sea Urchin Paracentrotus lividus: Gene Structure, Differential Expression and Phylogenetic Analysis

PubMed Central

Ragusa, Maria Antonietta; Nicosia, Aldo; Costa, Salvatore; Cuttitta, Angela; Gianguzza, Fabrizio

2017-01-01

Metallothioneins (MT) are small and cysteine-rich proteins that bind metal ions such as zinc, copper, cadmium, and nickel. In order to shed some light on MT gene structure and evolution, we cloned seven Paracentrotus lividus MT genes, comparing them to Echinodermata and Chordata genes. Moreover, we performed a phylogenetic analysis of 32 MTs from different classes of echinoderms and 13 MTs from the most ancient chordates, highlighting the relationships between them. Since MTs have multiple roles in the cells, we performed RT-qPCR and in situ hybridization experiments to understand better MT functions in sea urchin embryos. Results showed that the expression of MTs is regulated throughout development in a cell type-specific manner and in response to various metals. The MT7 transcript is expressed in all tissues, especially in the stomach and in the intestine of the larva, but it is less metal-responsive. In contrast, MT8 is ectodermic and rises only at relatively high metal doses. MT5 and MT6 expression is highly stimulated by metals in the mesenchyme cells. Our results suggest that the P. lividus MT family originated after the speciation events by gene duplications, evolving developmental and environmental sub-functionalization. PMID:28417916

Genome Structures and Transcriptomes Signify Niche Adaptation for the Multiple-Ion-Tolerant Extremophyte Schrenkiella parvula1[C][W][OPEN

PubMed Central

Oh, Dong-Ha; Hong, Hyewon; Lee, Sang Yeol; Yun, Dae-Jin; Bohnert, Hans J.; Dassanayake, Maheshi

2014-01-01

Schrenkiella parvula (formerly Thellungiella parvula), a close relative of Arabidopsis (Arabidopsis thaliana) and Brassica crop species, thrives on the shores of Lake Tuz, Turkey, where soils accumulate high concentrations of multiple-ion salts. Despite the stark differences in adaptations to extreme salt stresses, the genomes of S. parvula and Arabidopsis show extensive synteny. S. parvula completes its life cycle in the presence of Na+, K+, Mg2+, Li+, and borate at soil concentrations lethal to Arabidopsis. Genome structural variations, including tandem duplications and translocations of genes, interrupt the colinearity observed throughout the S. parvula and Arabidopsis genomes. Structural variations distinguish homologous gene pairs characterized by divergent promoter sequences and basal-level expression strengths. Comparative RNA sequencing reveals the enrichment of ion-transport functions among genes with higher expression in S. parvula, while pathogen defense-related genes show higher expression in Arabidopsis. Key stress-related ion transporter genes in S. parvula showed increased copy number, higher transcript dosage, and evidence for subfunctionalization. This extremophyte offers a framework to identify the requisite adjustments of genomic architecture and expression control for a set of genes found in most plants in a way to support distinct niche adaptation and lifestyles. PMID:24563282

Evolutionary origin of phytochrome responses and signaling in land plants.

PubMed

Inoue, Keisuke; Nishihama, Ryuichi; Kohchi, Takayuki

2017-11-01

Phytochromes comprise one of the major photoreceptor families in plants, and they regulate many aspects of plant growth and development throughout the plant life cycle. A canonical land plant phytochrome originated in the common ancestor of streptophytes. Phytochromes have diversified in seed plants and some basal land plants because of lineage-specific gene duplications that occurred during the course of land plant evolution. Molecular genetic analyses using Arabidopsis thaliana suggested that there are two types of phytochromes in angiosperms, light-labile type I and light-stable type II, which have different signaling mechanisms and which regulate distinct responses. In basal land plants, little is known about molecular mechanisms of phytochrome signaling, although red light/far-red photoreversible physiological responses and the distribution of phytochrome genes are relatively well documented. Recent advances in molecular genetics using the moss Physcomitrella patens and the liverwort Marchantia polymorpha revealed that basal land plants show far-red-induced responses and that the establishment of phytochrome-mediated transcriptional regulation dates back to at least the common ancestor of land plants. In this review, we summarize our knowledge concerning functions of land plant phytochromes, especially in basal land plants, and discuss subfunctionalization/neofunctionalization of phytochrome signaling during the course of land plant evolution. © 2017 John Wiley & Sons Ltd.

Diversity, classification and function of the plant protein kinase superfamily

PubMed Central

Lehti-Shiu, Melissa D.; Shiu, Shin-Han

2012-01-01

Eukaryotic protein kinases belong to a large superfamily with hundreds to thousands of copies and are components of essentially all cellular functions. The goals of this study are to classify protein kinases from 25 plant species and to assess their evolutionary history in conjunction with consideration of their molecular functions. The protein kinase superfamily has expanded in the flowering plant lineage, in part through recent duplications. As a result, the flowering plant protein kinase repertoire, or kinome, is in general significantly larger than other eukaryotes, ranging in size from 600 to 2500 members. This large variation in kinome size is mainly due to the expansion and contraction of a few families, particularly the receptor-like kinase/Pelle family. A number of protein kinases reside in highly conserved, low copy number families and often play broadly conserved regulatory roles in metabolism and cell division, although functions of plant homologues have often diverged from their metazoan counterparts. Members of expanded plant kinase families often have roles in plant-specific processes and some may have contributed to adaptive evolution. Nonetheless, non-adaptive explanations, such as kinase duplicate subfunctionalization and insufficient time for pseudogenization, may also contribute to the large number of seemingly functional protein kinases in plants. PMID:22889912

New Insights into Ligand-Receptor Pairing and Coevolution of Relaxin Family Peptides and Their Receptors in Teleosts

PubMed Central

Good, Sara; Yegorov, Sergey; Martijn, Joran; Franck, Jens; Bogerd, Jan

2012-01-01

Relaxin-like peptides (RLN/INSL) play diverse roles in reproductive and neuroendocrine processes in placental mammals and are functionally associated with two distinct types of receptors (RXFP) for each respective function. The diversification of RLN/INSL and RXFP gene families in vertebrates was predominantly driven by whole genome duplications (2R and 3R). Teleosts preferentially retained duplicates of genes putatively involved in neuroendocrine regulation, harboring a total of 10-11 receptors and 6 ligand genes, while most mammals have equal numbers of ligands and receptors. To date, the ligand-receptor relationships of teleost Rln/Insl peptides and their receptors have largely remained unexplored. Here, we use selection analyses based on sequence data from 5 teleosts and qPCR expression data from zebrafish to explore possible ligand-receptor pairings in teleosts. We find support for the hypothesis that, with the exception of RLN, which has undergone strong positive selection in mammalian lineages, the ligand and receptor genes shared between mammals and teleosts appear to have similar pairings. On the other hand, the teleost-specific receptors show evidence of subfunctionalization. Overall, this study underscores the complexity of RLN/INSL and RXFP ligand-receptor interactions in teleosts and establishes theoretical background for further experimental work in nonmammals. PMID:23008798

Forgotten and Ignored: Special Education in First Nations Schools in Canada

ERIC Educational Resources Information Center

Phillips, Ron

2010-01-01

Usually reviews of special education in Canada describe the special education programs, services, policies, and legislation that are provided by the provinces and territories. The reviews consistently ignore the special education programs, services, policies, and legislation that are provided by federal government of Canada. The federal government…

A Rural Special Education Teacher Training Program: Successful Adaptations.

ERIC Educational Resources Information Center

Prater, Greg; And Others

The Rural Special Education Program (RSEP), a partnership between Northern Arizona University (NAU) and Kayenta Unified School District (KUSD), provides training for preservice special education teachers to work with Native American students and their families. To date, the program has provided training for 63 preservice special education…

Special Education in Jordan

ERIC Educational Resources Information Center

Abu-Hamour, Bashir; Al-Hmouz, Hanan

2014-01-01

The purpose of this article is to provide a brief background about special education system in Jordan and particularly describes the present types of programmes and legislation provided within the country to students with special needs, as well as integration movement. Jordan has historically provided a limited number of educational opportunities…

SPECIAL CLASSES FOR STUDENTS WITH SPECIAL NEEDS.

ERIC Educational Resources Information Center

DOWELL, G.L.

A SPECIAL 3-YEAR TRAINING PROGRAM IN FARM POWER AND MACHINERY WAS DEVELOPED TO PROVIDE FOR DIFFERENT LEVELS OF STUDENT ACHIEVEMENT AND TO HELP MEET THE NEED FOR SKILLED WORKERS IN THE MISSISSIPPI DELTA AREA. CHANGES IN THE LEARNING ENVIRONMENT OF STUDENTS TRANSFERRED FROM REGULAR VOCATIONAL AGRICULTURE CLASSES TO THE SPECIAL CLASSES PROVIDE A MORE…

Spine concerns in the Special Olympian with Down syndrome.

PubMed

Tassone, James Channing; Duey-Holtz, Allison

2008-03-01

As with any child participating in sports, the safety of The Special Olympian participating in athletics is paramount. The preparticipation medical clearance is necessary to ensure these athletes' safety. In response to evidence that 15% of all individuals with Down syndrome have atlanto-occipital and/or atlanto-axial instability or subluxation, the Special Olympics Inc have additionally mandated preparticipation spine clearance for all individuals with Down syndrome. Spine clearance for the Special Olympian is challenging for the healthcare provider. In addition, controversy has arisen surrounding The Special Olympics Inc policy statement. The purposes of this article are to provide healthcare providers with a review of atlanto-occipital and atlanto-axial instability and subluxation, review spine clearance guidelines, discuss the details and controversy surrounding The Special Olympics Inc mandate, and provide recommendations on how to improve screening and ensure safety of the participants based on the current medical literature.

Tandem Duplication Events in the Expansion of the Small Heat Shock Protein Gene Family in Solanum lycopersicum (cv. Heinz 1706).

PubMed

Krsticevic, Flavia J; Arce, Débora P; Ezpeleta, Joaquín; Tapia, Elizabeth

2016-10-13

In plants, fruit maturation and oxidative stress can induce small heat shock protein (sHSP) synthesis to maintain cellular homeostasis. Although the tomato reference genome was published in 2012, the actual number and functionality of sHSP genes remain unknown. Using a transcriptomic (RNA-seq) and evolutionary genomic approach, putative sHSP genes in the Solanum lycopersicum (cv. Heinz 1706) genome were investigated. A sHSP gene family of 33 members was established. Remarkably, roughly half of the members of this family can be explained by nine independent tandem duplication events that determined, evolutionarily, their functional fates. Within a mitochondrial class subfamily, only one duplicated member, Solyc08g078700, retained its ancestral chaperone function, while the others, Solyc08g078710 and Solyc08g078720, likely degenerated under neutrality and lack ancestral chaperone function. Functional conservation occurred within a cytosolic class I subfamily, whose four members, Solyc06g076570, Solyc06g076560, Solyc06g076540, and Solyc06g076520, support ∼57% of the total sHSP RNAm in the red ripe fruit. Subfunctionalization occurred within a new subfamily, whose two members, Solyc04g082720 and Solyc04g082740, show heterogeneous differential expression profiles during fruit ripening. These findings, involving the birth/death of some genes or the preferential/plastic expression of some others during fruit ripening, highlight the importance of tandem duplication events in the expansion of the sHSP gene family in the tomato genome. Despite its evolutionary diversity, the sHSP gene family in the tomato genome seems to be endowed with a core set of four homeostasis genes: Solyc05g014280, Solyc03g082420, Solyc11g020330, and Solyc06g076560, which appear to provide a baseline protection during both fruit ripening and heat shock stress in different tomato tissues. Copyright © 2016 Krsticevic et al.

Tandem Duplication Events in the Expansion of the Small Heat Shock Protein Gene Family in Solanum lycopersicum (cv. Heinz 1706)

PubMed Central

Krsticevic, Flavia J.; Arce, Débora P.; Ezpeleta, Joaquín; Tapia, Elizabeth

2016-01-01

In plants, fruit maturation and oxidative stress can induce small heat shock protein (sHSP) synthesis to maintain cellular homeostasis. Although the tomato reference genome was published in 2012, the actual number and functionality of sHSP genes remain unknown. Using a transcriptomic (RNA-seq) and evolutionary genomic approach, putative sHSP genes in the Solanum lycopersicum (cv. Heinz 1706) genome were investigated. A sHSP gene family of 33 members was established. Remarkably, roughly half of the members of this family can be explained by nine independent tandem duplication events that determined, evolutionarily, their functional fates. Within a mitochondrial class subfamily, only one duplicated member, Solyc08g078700, retained its ancestral chaperone function, while the others, Solyc08g078710 and Solyc08g078720, likely degenerated under neutrality and lack ancestral chaperone function. Functional conservation occurred within a cytosolic class I subfamily, whose four members, Solyc06g076570, Solyc06g076560, Solyc06g076540, and Solyc06g076520, support ∼57% of the total sHSP RNAm in the red ripe fruit. Subfunctionalization occurred within a new subfamily, whose two members, Solyc04g082720 and Solyc04g082740, show heterogeneous differential expression profiles during fruit ripening. These findings, involving the birth/death of some genes or the preferential/plastic expression of some others during fruit ripening, highlight the importance of tandem duplication events in the expansion of the sHSP gene family in the tomato genome. Despite its evolutionary diversity, the sHSP gene family in the tomato genome seems to be endowed with a core set of four homeostasis genes: Solyc05g014280, Solyc03g082420, Solyc11g020330, and Solyc06g076560, which appear to provide a baseline protection during both fruit ripening and heat shock stress in different tomato tissues. PMID:27565886

An adaptive radiation model for the origin of new genefunctions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Francino, M. Pilar

2004-10-18

The evolution of new gene functions is one of the keys to evolutionary innovation. Most novel functions result from gene duplication followed by divergence. However, the models hitherto proposed to account for this process are not fully satisfactory. The classic model of neofunctionalization holds that the two paralogous gene copies resulting from a duplication are functionally redundant, such that one of them can evolve under no functional constraints and occasionally acquire a new function. This model lacks a convincing mechanism for the new gene copies to increase in frequency in the population and survive the mutational load expected to accumulatemore » under neutrality, before the acquisition of the rare beneficial mutations that would confer new functionality. The subfunctionalization model has been proposed as an alternative way to generate genes with altered functions. This model also assumes that new paralogous gene copies are functionally redundant and therefore neutral, but it predicts that relaxed selection will affect both gene copies such that some of the capabilities of the parent gene will disappear in one of the copies and be retained in the other. Thus, the functions originally present in a single gene will be partitioned between the two descendant copies. However, although this model can explain increases in gene number, it does not really address the main evolutionary question, which is the development of new biochemical capabilities. Recently, a new concept has been introduced into the gene evolution literature which is most likely to help solve this dilemma. The key point is to allow for a period of natural selection for the duplication per se, before new function evolves, rather than considering gene duplication to be neutral as in the previous models. Here, I suggest a new model that draws on the advantage of postulating selection for gene duplication, and proposes that bursts of adaptive gene amplification in response to specific selection pressures provide the raw material for the evolution of new function.« less

Hospice and nursing homes.

PubMed

Castle, N G

1999-01-01

In this article a descriptive analysis of nursing homes with special care hospice units is provided. These are compared to nursing homes with other special care units and to nursing homes without any special care units. An analysis of the determinants of nursing homes with special care hospice units is also provided. Factors such as ownership, staffing levels, having other special care units, case-mix intensity, competitiveness of the nursing home market, and the state Medicaid reimbursement rate structure are examined. Finally, the influence of policies on hospice care in nursing homes is discussed.

Building Medical Homes for Children with Special Health Care Needs.

ERIC Educational Resources Information Center

Nickel, Robert E.; Cooley, W. Carl; McAllister, Jeanne W.; Samson-Fang, Lisa

2003-01-01

Discussion of medical homes for children with special health care needs suggests such homes can provide quality health care services to children in partnership with families and community professionals. Early intervention and early childhood special education providers are encouraged to collaborate with primary health care professionals, thereby…

47 CFR 15.27 - Special accessories.

Code of Federal Regulations, 2010 CFR

2010-10-01

... information required by this section may be included in the manual in that alternative form, provided the user..., shall ensure that these special accessories are provided with the equipment. The instruction manual for... responsibility of the user to use the needed special accessories supplied with the equipment. In cases where the...

Surrogate Parents in California Special Education: A Resource Notebook.

ERIC Educational Resources Information Center

California State Univ., Sacramento.

This resource notebook presents samples of training materials and local policies and procedures and is intended to accompany an overview document which provides information on California legislation concerning surrogate parents in special education. Part 1 provides a summary of special education laws, services, and parent and student rights. Part…

Inclusive Resources for Science and Special Educational Needs.

ERIC Educational Resources Information Center

Fenton, Adrian

2002-01-01

Introduces a CD-ROM that provides support for inclusive science and special education. Provides a full-scale investigation, resources for lessons, and management strategies for special needs students in science, and includes the themes of coastline protection, micro-scale chemistry, torches and color, fast plants, and flashcards software. (YDS)

Specialized Prisons and Services: Results From a National Survey

PubMed Central

Cropsey, Karen L.; Wexler, Harry K.; Melnick, Gerald; Taxman, Faye S.; Young, Douglas W.

2008-01-01

Findings from the National Criminal Justice Drug Abuse Treatment Studies (CJ-DATS) National Criminal Justice Treatment Practices survey are examined to describe types of services provided by three types of prisons: those that serve a cross-section of offenders, those that specialize in serving offenders with special psychosocial and medical needs, and those that specialize in serving legal status or gender specific populations. Information is presented on the prevalence and type of specialized prisons and services provided to offenders as reported by wardens and other facility directors drawn from a nationally representative sample of prisons. Additional analyses explore organizational factors that differentiate prisons that serve specialized populations including staffing, training, other resources, leadership, and climate for change and innovation. Implications for expanding and improving services for special populations in correctional settings and the values of specialized prisons are discussed. PMID:18443650

Diversification of Transcriptional Regulation Determines Subfunctionalization of Paralogous Branched Chain Aminotransferases in the Yeast Saccharomyces cerevisiae.

PubMed

González, James; López, Geovani; Argueta, Stefany; Escalera-Fanjul, Ximena; El Hafidi, Mohammed; Campero-Basaldua, Carlos; Strauss, Joseph; Riego-Ruiz, Lina; González, Alicia

2017-11-01

Saccharomyces cerevisiae harbors BAT1 and BAT2 paralogous genes that encode branched chain aminotransferases and have opposed expression profiles and physiological roles . Accordingly, in primary nitrogen sources such as glutamine, BAT1 expression is induced, supporting Bat1-dependent valine-isoleucine-leucine (VIL) biosynthesis, while BAT2 expression is repressed. Conversely, in the presence of VIL as the sole nitrogen source, BAT1 expression is hindered while that of BAT2 is activated, resulting in Bat2-dependent VIL catabolism. The presented results confirm that BAT1 expression is determined by transcriptional activation through the action of the Leu3-α-isopropylmalate (α-IPM) active isoform, and uncovers the existence of a novel α-IPM biosynthetic pathway operating in a put3 Δ mutant grown on VIL, through Bat2-Leu2-Leu1 consecutive action. The classic α-IPM biosynthetic route operates in glutamine through the action of the leucine-sensitive α-IPM synthases. The presented results also show that BAT2 repression in glutamine can be alleviated in a ure2 Δ mutant or through Gcn4-dependent transcriptional activation. Thus, when S. cerevisiae is grown on glutamine, VIL biosynthesis is predominant and is preferentially achieved through BAT1 ; while on VIL as the sole nitrogen source, catabolism prevails and is mainly afforded by BAT2 . Copyright © 2017 by the Genetics Society of America.

Genome-wide characterization of the Pectate Lyase-like (PLL) genes in Brassica rapa.

PubMed

Jiang, Jingjing; Yao, Lina; Miao, Ying; Cao, Jiashu

2013-11-01

Pectate lyases (PL) depolymerize demethylated pectin (pectate, EC 4.2.2.2) by catalyzing the eliminative cleavage of α-1,4-glycosidic linked galacturonan. Pectate Lyase-like (PLL) genes are one of the largest and most complex families in plants. However, studies on the phylogeny, gene structure, and expression of PLL genes are limited. To understand the potential functions of PLL genes in plants, we characterized their intron-exon structure, phylogenetic relationships, and protein structures, and measured their expression patterns in various tissues, specifically the reproductive tissues in Brassica rapa. Sequence alignments revealed two characteristic motifs in PLL genes. The chromosome location analysis indicated that 18 of the 46 PLL genes were located in the least fractionated sub-genome (LF) of B. rapa, while 16 were located in the medium fractionated sub-genome (MF1) and 12 in the more fractionated sub-genome (MF2). Quantitative RT-PCR analysis showed that BrPLL genes were expressed in various tissues, with most of them being expressed in flowers. Detailed qRT-PCR analysis identified 11 pollen specific PLL genes and several other genes with unique spatial expression patterns. In addition, some duplicated genes showed similar expression patterns. The phylogenetic analysis identified three PLL gene subfamilies in plants, among which subfamily II might have evolved from gene neofunctionalization or subfunctionalization. Therefore, this study opens the possibility for exploring the roles of PLL genes during plant development.

Eyes with basic dorsal and specific ventral regions in the glacial Apollo, Parnassius glacialis (Papilionidae).

PubMed

Awata, Hiroko; Matsushita, Atsuko; Wakakuwa, Motohiro; Arikawa, Kentaro

2010-12-01

Recent studies on butterflies have indicated that their colour vision system is almost species specific. To address the question of how this remarkable diversity evolved, we investigated the eyes of the glacial Apollo, Parnassius glacialis, a living fossil species belonging to the family Papilionidae. We identified four opsins in the Parnassius eyes--an ultraviolet- (PgUV), a blue- (PgB), and two long wavelength (PgL2, PgL3)-absorbing types--and localized their mRNAs within the retina. We thus found ommatidial heterogeneity and a clear dorso-ventral regionalization of the eye. The dorsal region consists of three basic types of ommatidia that are similar to those found in other insects, indicating that this dorsal region retains the ancestral state. In the ventral region, we identified two novel phenomena: co-expression of the opsins of the UV- and B-absorbing type in a subset of photoreceptors, and subfunctionalization of long-wavelength receptors in the distal tier as a result of differential expression of the PgL2 and PgL3 mRNAs. Interestingly, butterflies from the closely related genus Papilio (Papilionidae) have at least three long-wavelength opsins, L1-L3. The present study indicates that the duplication of L2 and L3 occurred before the Papilio lineage diverged from the rest, whereas L1 was produced from L3 in the Papilio lineage.

Preparing Special Educators for Teacher Consultation.

ERIC Educational Resources Information Center

Warger, Cynthia L., Ed.; Aldinger, Loviah E., Ed.

The publication defines the nature of special education consultation and presents various options through which training can be provided by college and university departments of special education. The first three papers present the realities of special education consultation as currently practiced: "Serving Special Children through Teacher…

Ending Discrimination in Special Education. Second Edition.

ERIC Educational Resources Information Center

Grossman, Herbert

This book discusses the forces that create and perpetuate discrimination in special education and provides suggestions for eliminating discriminatory practices. An introduction describes the harmful effects of discrimination in special education. Chapters 1 and 2 discuss prejudice in special education and suggest how special education educators…

Distribution of specialized care centers in the United States.

PubMed

Wang, Henry E; Yealy, Donald M

2012-11-01

As a recommended strategy for optimally managing critical illness, regionalization of care involves matching the needs of the target population with available hospital resources. The national supply and characteristics of hospitals providing specialized critical care services is currently unknown. We seek to characterize the current distribution of specialized care centers in the United States. Using public data linked with the American Hospital Association directory and US Census, we identified US general acute hospitals providing specialized care for ST-segment elevation myocardial infarction (STEMI) (≥40 annual primary percutaneous coronary interventions reported in Medicare Hospital Compare), stroke (The Joint Commission certified stroke centers), trauma (American College of Surgeons or state-designated, adult or pediatric, level I or II), and pediatric critical care (presence of a pediatric ICU) services. We determined the characteristics and state-level distribution and density of specialized care centers (centers per state and centers per state population). Among 4,931 acute care hospitals in the United States, 1,325 (26.9%) provided one of the 4 defined specialized care services, including 574 STEMI, 763 stroke, 508 trauma, and 457 pediatric critical care centers. Approximately half of the 1,325 hospitals provided 2 or more specialized services, and one fifth provided 3 or 4 specialized services. There was variation in the number of each type of specialized care center in each state: STEMI median 7 interquartile range (IQR 2 to 14), stroke 8 (IQR 3 to 17), trauma 6 (IQR 3 to 11), pediatric specialized care 6 (IQR 3 to 11). Similarly, there was variation in the number of each type of specialized care center per population: STEMI median 1 center per 585,135 persons (IQR 418,729 to 696,143), stroke 1 center per 412,188 persons (IQR 321,604 to 572,387), trauma 1 center per 610,589 persons (IQR 406,192 to 917,588), and pediatric critical care 1 center per 665,282 persons (IQR 441,525 to 942,254). The national distribution patterns differed for each type of specialized care center. The distribution of specialized care centers varies across the United States. These observations highlight unanswered questions about the regional organization of specialized care in the United States. Copyright © 2012. Published by Mosby, Inc.

76 FR 80410 - Pendency of Request for Approval of Special Withdrawal Liability Rules; the Cultural Institutions...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

... Liability Rules; the Cultural Institutions Pension Plan AGENCY: Pension Benefit Guaranty Corporation. ACTION... approval of a plan amendment providing for special withdrawal liability rules. Under Sec. 4203(f) of the... Liability Rules, a multiemployer pension plan may, with PBGC approval, be amended to provide for special...

Music Integration Therapy: An Instructional Tool for Students with Special Needs

ERIC Educational Resources Information Center

Rodriguez, Delilah

2017-01-01

Students with special needs are required by law to have an individualized education plan based on their unique educational needs. Special education teachers understand these needs and provide students with instructional strategies that allow them to succeed. Music has often been used to provide students with disabilities alternative ways to learn…

Improving Professional Development to Enhance Reading Outcomes for Students in Special Education.

PubMed

Lemons, Christopher J; Otaiba, Stephanie Al; Conway, Sheila J; Mellado De La Cruz, Veronica

2016-12-01

The purpose of this article is to focus specifically on professional development that is needed to ensure that preservice and in-service teachers are prepared to deliver intensive intervention to enhance reading outcomes of students in special education. Our aim is to provide recommendations to ensure that special educators are prepared to design and implement data-based individualization in the area of reading. We highlight what special educators need to know to implement data-based individualization and provide recommendations for improving professional development using findings from federally funded projects. Implications for practice and next steps for research and policy are provided. © 2016 Wiley Periodicals, Inc.

Cultivating and Keeping Committed Special Education Teachers: What Principals and District Leaders Can Do

ERIC Educational Resources Information Center

Billingsley, Bonnie S.

2005-01-01

This book highlights the problems that drive many special educators out of teaching and outlines practical recommendations that leaders can use to increase retention. Drawing on field experience as well as research findings, the author provides a comprehensive framework for supporting special educators. This book provides effective ways to: (1)…

75 FR 37 - Special Conditions: Airbus Model A330 Series Airplanes; Seats with Non-Traditional, Large, Non...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

...-traditional, large, non-metallic panels. To provide a level of safety that is equivalent to that provided by...; Special Conditions No. 25-400-SC] Special Conditions: Airbus Model A330 Series Airplanes; Seats with Non-Traditional, Large, Non-Metallic Panels AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final...

Case-mix specialization in the market for hospital services.

PubMed Central

Farley, D E; Hogan, C

1990-01-01

Historically, cost-based reimbursement encouraged hospitals to compete on the basis of quality, leading to duplication of services and other inefficient behavior. More recently, prospective payment, selective contracting, and other innovations in reimbursement have strengthened incentives for more efficient hospital operations. In principle, hospitals may be able to reduce their costs by limiting the array of services they provide, but there has been little empirical evidence that U.S. hospitals are moving toward greater specialization or that specialization leads to cost savings. This article explores recent changes in case-mix specialization and the relationship of these changes to hospital costs. It first describes an index of specialization derived from Information Theory and shows that this index provides intuitively reasonable results in characterizing patterns of specialization across hospitals. The analysis then demonstrates that specialization, as measured by this index, in fact increased from 1980 through 1985; that specialization can indeed lower hospital costs; and that increases in specialization have been largest in those hospitals with the greatest incentives to reduce costs. PMID:2123838

Let's Find the Special People: Identifying and Locating the Special Needs Learners. "It Isn't Easy Being Special." Research & Development Series No. 176.

ERIC Educational Resources Information Center

Campbell-Thrane, Lucille, Ed.

This publication presents a data collection system useful in measuring the success of vocational programs for special needs populations as well as current descriptive/demographic information on special needs populations nationwide. The first of four chapters provides a general characterization of special populations and specific definitions for…

The Case for Increasing Workplace Decision-Making: Proposing a Model for Special Educator Attrition Research

ERIC Educational Resources Information Center

Tyler, Teresa A.; Brunner, C. Cryss

2014-01-01

The chronically high rate of special educator attrition across U.S. schools creates a dilemma for educational leaders because special educators provide direct services to students with special needs. Attrition exacerbates already high special educator shortages reported in most districts, and nearly one million schoolchildren with disabilities…

Progressive specialization within general surgery: adding to the complexity of workforce planning.

PubMed

Stitzenberg, Karyn B; Sheldon, George F

2005-12-01

Although most general surgeons receive comparable training leading to Board certification, the services they provide in practice may be highly variable. Progressive specialization is the voluntary narrowing of scope of practice from the breadth of skills acquired during training; it occurs in response to patient demand, rapid growth of medical knowledge, and personal factors. Progressive specialization is increasingly linked to fellowship training, which generally abruptly narrows a surgeon's scope of practice. This study examines progressive specialization by evaluating trends in fellowship training among general surgeons. Because no database exists that tracks trainees from medical school matriculation through entrance into the workforce, data from multiple sources were compiled to assess the impact of progressive specialization. Trends in overall number of trainees, match rates, and proportion of international medical graduates were analyzed. The proportion of general surgeons pursuing fellowship training has increased from > 55% to > 70% since 1992. The introduction of fellowship opportunities in newer content areas, such as breast surgery and minimally invasive surgery, accounts for some of the increase. Meanwhile, interest in more traditional subspecialties (ie, thoracic and vascular surgery) is declining. Progressive specialization confounds workforce projections. Available databases provide only an estimate of the extent of progressive specialization. When surgeons complete fellowships, they narrow the spectrum of services provided. Consequently, as the phenomenon of progressive specialization evolves, a larger surgical workforce will be needed to provide the breadth of services encompassed by the primary components of general surgery.

An Analysis of Social Skills Instruction Provided in Teacher Education and In-Service Training Programs for General and Special Educators

ERIC Educational Resources Information Center

Dobbins, Nicole; Higgins, Kyle; Pierce, Tom; Tandy, Richard D.; Tincani, Matt

2010-01-01

An adapted version of the "Teacher/Staff Skillstreaming Checklist" was used to determine the level, type, and area of social skills instruction provided to general and special education teachers. Nine universities participated in the study in which facilitators advertised the adapted questionnaire to licensed general and special education teachers…

29 CFR 825.604 - Special rules for school employees, restoration to “an equivalent position.”

Code of Federal Regulations, 2010 CFR

2010-07-01

... employee to “an equivalent position” must provide substantially the same protections as provided in the Act... 29 Labor 3 2010-07-01 2010-07-01 false Special rules for school employees, restoration to âan... to Employees of Schools § 825.604 Special rules for school employees, restoration to “an equivalent...

Special Events from A to Z: The Complete Educator's Handbook.

ERIC Educational Resources Information Center

Jasso, Gayle

This handbook offers guidelines for coordinating a special school event or activity. Chapter 1 provides answers to frequently asked questions about special events. Chapter 2 describes the benefits and risks of acting as a special-events coordinator. The 12 phases of planning a special event and bringing it to culmination are outlined in the third…

Inclusive Special Education: Development of a New Theory for the Education of Children with Special Educational Needs and Disabilities

ERIC Educational Resources Information Center

Hornby, Garry

2015-01-01

Inclusive education and special education are based on different philosophies and provide alternative views of education for children with special educational needs and disabilities. They are increasingly regarded as diametrically opposed in their approaches. This article presents a theory of "inclusive special education" that comprises…

Educating People With Special Needs in Nigeria: Present and Future Perspectives

ERIC Educational Resources Information Center

Eskay, Michael; Eskay, Obidiya; Uma, Emea

2012-01-01

For a long time, children with special needs were educated along with other regular children in schools. The notion of special education was a western phenomenon and concept in Nigeria. How were children with special needs educated without special education programs? This paper will provide cultural perspectives on issues of disability and caring…

Una Guia para Los Padres sobre La Educacion Especial: El Derecho de Su Hijo(a) a Adquirir una Educacion en el Estado de Nueva York (A Parent's Guide to Special Education: Your Child's Right to an Education in New York State).

ERIC Educational Resources Information Center

New York State Education Dept. Albany. Office for the Education of Children with Handicapping Conditions.

This guide provides information to help parents of special needs children in New York become active partners in the planning and implementation of special education programs. The first part of the guide provides in-depth information related to the special education process in New York State public schools. A historical view of children's rights to…

50 CFR 21.27 - Special purpose permits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... WILDLIFE AND PLANTS (CONTINUED) MIGRATORY BIRD PERMITS Specific Permit Provisions § 21.27 Special purpose permits. Permits may be issued for special purpose activities related to migratory birds, their parts... special purpose permit for migratory bird related activities not otherwise provided for in this part may...

MCPS Special Education at a Glance 2012-2013

ERIC Educational Resources Information Center

Montgomery County Public Schools, 2013

2013-01-01

Montgomery County Public Schools (MCPS) "Special Education at a Glance," which includes a copy of the "Guide to Planning and Assessing School-Based Special Education Programs," provides in a single document, information about the special education population at each Montgomery County (Maryland) public school, including…

MCPS Special Education at a Glance 2011-2012

ERIC Educational Resources Information Center

Montgomery County Public Schools, 2012

2012-01-01

Montgomery County Public Schools (MCPS) "Special Education at a Glance," which includes a copy of the "Guide to Planning and Assessing School-Based Special Education Programs," provides in a single document, information about the special education population at each Montgomery County (Maryland) public school, including…

Engaging Students in Modeling as an Epistemic Practice of Science: An Introduction to the Special Issue of the "Journal of Science Education and Technology"

ERIC Educational Resources Information Center

Campbell, Todd; Oh, Phil Seok

2015-01-01

This article provides an introduction for the special issue of the "Journal of Science Education and Technology" focused on science teaching and learning with models. The article provides initial framing for questions that guided the special issue. Additionally, based on our careful review of each of these articles, some discussion of…

Using a Lesson Template To Integrate General and Special Education: Teaching Lesson Template Use to Educators of Students with Special Needs.

ERIC Educational Resources Information Center

Murry, Francie R.; Murry, G. Brandon

Teacher preparation programs have recognized their obligation to provide solutions for the dilemmas their teachers face once in the inclusive educational environment. The changing demands required by both general and special education teachers at the K-12 level are being addressed. One of these solutions is to provide access to technological…

19 CFR 200.735-122 - Special Government employees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 3 2012-04-01 2012-04-01 false Special Government employees. 200.735-122 Section... Government employees. (a) Except as provided in paragraph (b) of this section, each special Government... employment; and (2) The financial interests of the special Government employee which the Commission...

19 CFR 200.735-122 - Special Government employees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Special Government employees. 200.735-122 Section... Government employees. (a) Except as provided in paragraph (b) of this section, each special Government... employment; and (2) The financial interests of the special Government employee which the Commission...

Special Education Teachers' Nature of Science Instructional Experiences

ERIC Educational Resources Information Center

Mulvey, Bridget K.; Chiu, Jennifer L.; Ghosh, Rajlakshmi; Bell, Randy L.

2016-01-01

Special education teachers provide critical science instruction to students. However, little research investigates special education teacher beliefs and practices around science in general or the nature of science and inquiry in particular. This investigation is a cross-case analysis of four elementary special education teachers' initial…

MCPS Special Education at a Glance 2013-2014

ERIC Educational Resources Information Center

Montgomery County Public Schools, 2014

2014-01-01

Montgomery County Public Schools (MCPS) "Special Education at a Glance," which includes a copy of the "Guide to Planning and Assessing School-Based Special Education Programs," provides in a single document, information about the special education population at each Montgomery County public school, including enrollment,…

Cookbooks and Good Eating: Cookbooks for Special Populations.

ERIC Educational Resources Information Center

Ensign, Arselia S., Ed.

1990-01-01

The brochure briefly describes approximately 50 cookbooks and related materials appropriate for use with special populations. For most entries, title, author, source, price, and a brief description are provided. Entries include general cookbooks, large print and Braille cookbooks, cookbooks for special diets, cookbooks for special conditions,…

Introduction to the Special Section on Resurgence

ERIC Educational Resources Information Center

Kestner, Kathryn M.; Peterson, Stephanie M.; Wacker, David P.

2017-01-01

In this introduction, the editors provide an overview of resurgence and its importance to practitioners. They also provide an overview of the four articles contained in this special section focusing on the applied implications of resurgence.

34 CFR 380.1 - What is the program of special projects and demonstrations for providing supported employment...

Code of Federal Regulations, 2012 CFR

2012-07-01

... demonstrations for providing supported employment services to individuals with the most severe disabilities and... employment services to individuals with the most severe disabilities, including projects that demonstrate the... SPECIAL PROJECTS AND DEMONSTRATIONS FOR PROVIDING SUPPORTED EMPLOYMENT SERVICES TO INDIVIDUALS WITH THE...

34 CFR 380.1 - What is the program of special projects and demonstrations for providing supported employment...

Code of Federal Regulations, 2011 CFR

2011-07-01

... demonstrations for providing supported employment services to individuals with the most severe disabilities and... employment services to individuals with the most severe disabilities, including projects that demonstrate the... SPECIAL PROJECTS AND DEMONSTRATIONS FOR PROVIDING SUPPORTED EMPLOYMENT SERVICES TO INDIVIDUALS WITH THE...

34 CFR 380.1 - What is the program of special projects and demonstrations for providing supported employment...

Code of Federal Regulations, 2013 CFR

2013-07-01

... demonstrations for providing supported employment services to individuals with the most severe disabilities and... employment services to individuals with the most severe disabilities, including projects that demonstrate the... SPECIAL PROJECTS AND DEMONSTRATIONS FOR PROVIDING SUPPORTED EMPLOYMENT SERVICES TO INDIVIDUALS WITH THE...

34 CFR 380.1 - What is the program of special projects and demonstrations for providing supported employment...

Code of Federal Regulations, 2014 CFR

2014-07-01

... demonstrations for providing supported employment services to individuals with the most severe disabilities and... employment services to individuals with the most severe disabilities, including projects that demonstrate the... SPECIAL PROJECTS AND DEMONSTRATIONS FOR PROVIDING SUPPORTED EMPLOYMENT SERVICES TO INDIVIDUALS WITH THE...

Back-to-School Special Education Technology Resource Guide.

ERIC Educational Resources Information Center

Edyburn, Dave L., Ed.

1990-01-01

This newsletter special issue provides a compendium of information, strategies, and resources concerning the use of technology by individuals with special needs. A section on strategies for the effective use of technology contains the following papers: "A Philosophy for the Use of Technology in Special Education" (A. Edward Blackhurst…

77 FR 25075 - Special Local Regulation; Galveston Bay, Kemah, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-27

...-AA08 Special Local Regulation; Galveston Bay, Kemah, TX AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary special local regulation in Galveston Bay in the vicinity of Kemah, Texas. This temporary special local regulation is necessary to provide...

Vocational Education for Special Groups. Sixth Yearbook.

ERIC Educational Resources Information Center

Wall, James E., Ed.

Issues, concepts, and strategies that impact directly on the ability of vocational education to deliver its services to special groups are the focus of this yearbook. Chapters by 24 different authors are divided into three sections. Section 1 provides an overview of special groups, how special groups evolved, their underlying structure and…

Special Education Teacher Preparation in the Gulf Cooperation Council Countries

ERIC Educational Resources Information Center

Keller, Clayton; Al-Hendawi, Maha; Abuelhassan, Hadeel

2016-01-01

The provision of special education for students with disabilities depends upon the availability of well-qualified special educators, which, in turn, depends upon the availability and characteristics of preparation programs. In countries of the world where special education systems are still developing the capacity to provide the education that…

The Preparation of Counseling Personnel to Serve Special Needs Students.

ERIC Educational Resources Information Center

Parker, Linda G.; Stodden, Robert A.

1981-01-01

Discusses the elementary school counselor's role in providing affective education to special needs students. Explores the need for special education courses in counselor training. Results of a national survey indicated only two states required a course in special education for counselor certification. Suggests recommendations for updating…

Disability within the African Culture

ERIC Educational Resources Information Center

Eskay, M.; Onu, V. C.; Igbo, J. N.; Obiyo, N.; Ugwuanyi, L.

2012-01-01

For a long time, children with special needs were educated along with other regular children in schools. The notion of special education was a Western phenomenon and concept in Nigeria. How were children with special needs educated without special education programs? This article will provide cultural perspectives on issues of disability and care…

Special and Research Permits for Ocean Dumping

EPA Pesticide Factsheets

Special permits and research permits under the Marine Protection, Research and Sanctuaries Act may be issued by EPA for ocean dumping. Examples and ocean disposal sites for special and research permits are provided.

Delivery and Evaluation of Training for School Nutrition Administrators and Managers on Meeting Special Food and Nutrition Needs of Students in the School Setting

ERIC Educational Resources Information Center

Oakley, Charlotte B.; Knight, Kathy; Hobbs, Margie; Dodd, Lacy M.; Cole, Janie

2011-01-01

Purpose/Objectives: The purpose of this investigation was to complete a formal evaluation of a project that provided specialized training for school nutrition (SN) administrators and managers on meeting children's special dietary needs in the school setting. Methods: The training was provided as part of the "Eating Good and Moving Like We…

Evolution of developmental roles of Pax2/5/8 paralogs after independent duplication in urochordate and vertebrate lineages.

PubMed

Bassham, Susan; Cañestro, Cristian; Postlethwait, John H

2008-08-22

Gene duplication provides opportunities for lineage diversification and evolution of developmental novelties. Duplicated genes generally either disappear by accumulation of mutations (nonfunctionalization), or are preserved either by the origin of positively selected functions in one or both duplicates (neofunctionalization), or by the partitioning of original gene subfunctions between the duplicates (subfunctionalization). The Pax2/5/8 family of important developmental regulators has undergone parallel expansion among chordate groups. After the divergence of urochordate and vertebrate lineages, two rounds of independent gene duplications resulted in the Pax2, Pax5, and Pax8 genes of most vertebrates (the sister group of the urochordates), and an additional duplication provided the pax2a and pax2b duplicates in teleost fish. Separate from the vertebrate genome expansions, a duplication also created two Pax2/5/8 genes in the common ancestor of ascidian and larvacean urochordates. To better understand mechanisms underlying the evolution of duplicated genes, we investigated, in the larvacean urochordate Oikopleura dioica, the embryonic gene expression patterns of Pax2/5/8 paralogs. We compared the larvacean and ascidian expression patterns to infer modular subfunctions present in the single pre-duplication Pax2/5/8 gene of stem urochordates, and we compared vertebrate and urochordate expression to infer the suite of Pax2/5/8 gene subfunctions in the common ancestor of olfactores (vertebrates + urochordates). Expression pattern differences of larvacean and ascidian Pax2/5/8 orthologs in the endostyle, pharynx and hindgut suggest that some ancestral gene functions have been partitioned differently to the duplicates in the two urochordate lineages. Novel expression in the larvacean heart may have resulted from the neofunctionalization of a Pax2/5/8 gene in the urochordates. Expression of larvacean Pax2/5/8 in the endostyle, in sites of epithelial remodeling, and in sensory tissues evokes like functions of Pax2, Pax5 and Pax8 in vertebrate embryos, and may indicate ancient origins for these functions in the chordate common ancestor. Comparative analysis of expression patterns of chordate Pax2/5/8 duplicates, rooted on the single-copy Pax2/5/8 gene of amphioxus, whose lineage diverged basally among chordates, provides new insights into the evolution and development of the heart, thyroid, pharynx, stomodeum and placodes in chordates; supports the controversial conclusion that the atrial siphon of ascidians and the otic placode in vertebrates are homologous; and backs the notion that Pax2/5/8 functioned in ancestral chordates to engineer epithelial fusions and perforations, including gill slit openings.

Audit Oversight: Quality Control System at U.S. Special Operations Command Inspector General Audit Division

DTIC Science & Technology

2002-08-21

The Audit Division provides the Commander, U.S. Special Operations Command (USSOCOM) with professional auditing services to safeguard, account for...and ensure the proper use of special operations forces assets in accomplishing the USSOCOM mission. The Audit Division reports to the USSOCOM Inspector...U.S. Army Special Operations Command, Naval Special Warfare Command, and the Joint Special Operations Command. Appendix A contains a summary of the Audit Division policy and procedures.

The relationship between hospital specialization and hospital efficiency: do different measures of specialization lead to different results?

PubMed

Lindlbauer, Ivonne; Schreyögg, Jonas

2014-12-01

This study investigated the relationship between hospital specialization and technical efficiency using different measures of specialization, including two novel approaches based on patient volumes rather than patient proportions. It was motivated by the observation that most studies to date have quantified hospital specialization using information about hospital patients grouped into different categories based on their diagnosis, and in doing so have used proportions-thus indirectly assuming that these categories are dependent on one other. In order to account for the diversification of organizations and the idea that hospitals can be specialized in terms of professional expertise or technical equipment within a given diagnosis category, we developed our two specialization measures based on patient volume in each category. Using a one-step stochastic frontier approach on randomly selected data from the annual reports of 1,239 acute care German hospitals for the years 2000 through 2010, we estimated the relationship of inefficiency to exogenous variables, such as specialization. The results show that specialization as quantified by our novel measures has effects on efficiency that are the opposite of those obtained using earlier measures of specialization. These results underscore the importance of always providing an exact definition of specialization when studying its effects. Additionally, a Monte Carlo simulation based on three scenarios is provided to facilitate the choice of a specialization measure for further analysis.

State Special Education Finance Systems, 1999-2000. Part II: Special Education Revenues and Expenditures

ERIC Educational Resources Information Center

Parrish, Thomas; Harr, Jenifer; Wolman, Jean; Anthony, Jennifer; Merickel, Amy; Esra, Phil

2004-01-01

The Center for Special Education Finance (CSEF) provides policymakers and administrators at all governmental levels with data, analyses, expertise, and opportunities to share information about special education finance issues. One of CSEF's major activities is the periodic collection and dissemination of information on state funding systems for…

12 CFR 1024.6 - Special information booklet at time of loan application.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Special information booklet at time of loan... SETTLEMENT PROCEDURES ACT (REGULATION X) Mortgage Settlement and Escrow Accounts § 1024.6 Special information booklet at time of loan application. (a) Lender to provide special information booklet. Subject to the...

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

Guidelines for Becoming a Teacher Leader in Rural Special Education

ERIC Educational Resources Information Center

Collins, Belva C.; Leahy, Maria Marsella; Ault, Melinda Jones

2017-01-01

Special education teachers have a unique set of skills and opportunities to become leaders in the field of education. Some rural special education teachers, however, may not see themselves as potential leaders or believe they have opportunities to be leaders. This article provides guidelines for rural special education teachers to consider in…

Local Special Education Planning Model: User's Manual.

ERIC Educational Resources Information Center

Hartman, Peggy L.; Hartman, William T.

To help school districts estimate the present and future needs and costs of their special education programs, this manual presents the Local Special Education Planning Model, an interactive computer program (with worksheets) that provides a framework for using a district's own data to analyze its special education program. Part 1 of the manual…

Issues in Educating Students with Disabilities. The LEA Series on Special Education and Disability.

ERIC Educational Resources Information Center

Lloyd, John Wills, Ed.; Kameenui, Edward J., Ed.; Chard, David, Ed.

This book is designed to reaffirm the value of special instruction and to provide information on current research and practice which shows productive and successful outcomes. It addresses the definition of disabilities, the assessment of disabilities, instruction, special populations, special education legislation and policy, and integration.…

14 CFR 91.157 - Special VFR weather minimums.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Special VFR weather minimums. 91.157... Flight Rules § 91.157 Special VFR weather minimums. (a) Except as provided in appendix D, section 3, of this part, special VFR operations may be conducted under the weather minimums and requirements of this...

14 CFR 91.157 - Special VFR weather minimums.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Special VFR weather minimums. 91.157... Flight Rules § 91.157 Special VFR weather minimums. (a) Except as provided in appendix D, section 3, of this part, special VFR operations may be conducted under the weather minimums and requirements of this...

14 CFR 91.157 - Special VFR weather minimums.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Special VFR weather minimums. 91.157... Flight Rules § 91.157 Special VFR weather minimums. (a) Except as provided in appendix D, section 3, of this part, special VFR operations may be conducted under the weather minimums and requirements of this...

14 CFR 91.157 - Special VFR weather minimums.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Special VFR weather minimums. 91.157... Flight Rules § 91.157 Special VFR weather minimums. (a) Except as provided in appendix D, section 3, of this part, special VFR operations may be conducted under the weather minimums and requirements of this...

14 CFR 91.157 - Special VFR weather minimums.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Special VFR weather minimums. 91.157... Flight Rules § 91.157 Special VFR weather minimums. (a) Except as provided in appendix D, section 3, of this part, special VFR operations may be conducted under the weather minimums and requirements of this...

Modelling Inclusive Special Needs Education: Insights from Dutch Secondary Schools

ERIC Educational Resources Information Center

Van der Bij, T.; Geijsel, F. P.; Garst, G. J. A.; Ten Dam, G. T. M.

2016-01-01

Inclusive special needs education is prominent on the international education agenda. Research on the characteristics of inclusive education for students with special needs and schools providing this is scarce, however. Our aim in the present study was therefore to further theory-building with regard to inclusive special needs education. On the…

34 CFR 376.1 - What is the program of Special Projects and Demonstrations for Providing Transitional...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false What is the program of Special Projects and....1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL PROJECTS AND DEMONSTRATIONS FOR...

A Study on Family Opinions Concerning Services Provided in Special Education Centres

ERIC Educational Resources Information Center

Ugurlu, Necla Isikdogan; Kayhan, Nilay

2017-01-01

This study is to diagnose and evaluate children with different special needs medically and educationally and, as a result of those evaluations, to identify families' expectations, opinions and suggestions concerning the special education process, services and the functioning of special education institutions. The mothers of five children who…

Special Education in Mexico: One Community's Response.

ERIC Educational Resources Information Center

Shepherd, Terry L.; Contreras, Diana; Brown, Randel

2002-01-01

This article looks at the history of special education in Mexico, discusses the emergence of special education programs, and examines a school for special education in Nuevo Laredo, Tamaulipas. The school provides vocational training for students with a variety of disabilities and has a partnership with the local maquiladora industry. (Contains 5…

Handbook of Procedural Guidelines for Implementation of Special Education Curriculum: Critical Skills/Community-Based and Special Education Curriculum Guide.

ERIC Educational Resources Information Center

Riverside County Office of Education, CA. Div. of Special Schools and Services.

The special education procedural handbook and the special education curriculum guide provide guidelines for teachers and other school personnel. The procedural handbook covers the following areas: individual education program process (IEP) and program placement, individual education program team, administrative placements, parent interviews,…

Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II.

PubMed

Criscitiello, Michael F; Ohta, Yuko; Graham, Matthew D; Eubanks, Jeannine O; Chen, Patricia L; Flajnik, Martin F

2012-03-01

The invariant chain (Ii) is the critical third chain required for the MHC class II heterodimer to be properly guided through the cell, loaded with peptide, and expressed on the surface of antigen presenting cells. Here, we report the isolation of the nurse shark Ii gene, and the comparative analysis of Ii splice variants, expression, genomic organization, predicted structure, and function throughout vertebrate evolution. Alternative splicing to yield Ii with and without the putative protease-protective, thyroglobulin-like domain is as ancient as the MHC-based adaptive immune system, as our analyses in shark and lizard further show conservation of this mechanism in all vertebrate classes except bony fish. Remarkable coordinate expression of Ii and class II was found in shark tissues. Conserved Ii residues and cathepsin L orthologs suggest their long co-evolution in the antigen presentation pathway, and genomic analyses suggest 450 million years of conserved Ii exon/intron structure. Other than an extended linker preceding the thyroglobulin-like domain in cartilaginous fish, the Ii gene and protein are predicted to have largely similar physiology from shark to man. Duplicated Ii genes found only in teleosts appear to have become sub-functionalized, as one form is predicted to play the same role as that mediated by Ii mRNA alternative splicing in all other vertebrate classes. No Ii homologs or potential ancestors of any of the functional Ii domains were found in the jawless fish or lower chordates. Copyright © 2011 Elsevier Ltd. All rights reserved.

Maintenance and Loss of Duplicated Genes by Dosage Subfunctionalization.

PubMed

Gout, Jean-Francois; Lynch, Michael

2015-08-01

Whole-genome duplications (WGDs) have contributed to gene-repertoire enrichment in many eukaryotic lineages. However, most duplicated genes are eventually lost and it is still unclear why some duplicated genes are evolutionary successful whereas others quickly turn to pseudogenes. Here, we show that dosage constraints are major factors opposing post-WGD gene loss in several Paramecium species that share a common ancestral WGD. We propose a model where a majority of WGD-derived duplicates preserve their ancestral function and are retained to produce enough of the proteins performing this same ancestral function. Under this model, the expression level of individual duplicated genes can evolve neutrally as long as they maintain a roughly constant summed expression, and this allows random genetic drift toward uneven contributions of the two copies to total expression. Our analysis suggests that once a high level of imbalance is reached, which can require substantial lengths of time, the copy with the lowest expression level contributes a small enough fraction of the total expression that selection no longer opposes its loss. Extension of our analysis to yeast species sharing a common ancestral WGD yields similar results, suggesting that duplicated-gene retention for dosage constraints followed by divergence in expression level and eventual deterministic gene loss might be a universal feature of post-WGD evolution. © The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Paralogous SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) genes differentially regulate leaf initiation and reproductive phase change in petunia.

PubMed

Preston, Jill C; Jorgensen, Stacy A; Orozco, Rebecca; Hileman, Lena C

2016-02-01

Duplicated petunia clade-VI SPL genes differentially promote the timing of inflorescence and flower development, and leaf initiation rate. The timing of plant reproduction relative to favorable environmental conditions is a critical component of plant fitness, and is often associated with variation in plant architecture and habit. Recent studies have shown that overexpression of the microRNA miR156 in distantly related annual species results in plants with perennial characteristics, including late flowering, weak apical dominance, and abundant leaf production. These phenotypes are largely mediated through the negative regulation of a subset of genes belonging to the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) family of transcription factors. In order to determine how and to what extent paralogous SPL genes have partitioned their roles in plant growth and development, we functionally characterized petunia clade-VI SPL genes under different environmental conditions. Our results demonstrate that PhSBP1and PhSBP2 differentially promote discrete stages of the reproductive transition, and that PhSBP1, and possibly PhCNR, accelerates leaf initiation rate. In contrast to the closest homologs in annual Arabidopsis thaliana and Mimulus guttatus, PhSBP1 and PhSBP2 transcription is not mediated by the gibberellic acid pathway, but is positively correlated with photoperiod and developmental age. The developmental functions of clade-VI SPL genes have, thus, evolved following both gene duplication and speciation within the core eudicots, likely through differential regulation and incomplete sub-functionalization.

Regulation of Leaf Starch Degradation by Abscisic Acid Is Important for Osmotic Stress Tolerance in Plants[OPEN

PubMed Central

Thalmann, Matthias; Pazmino, Diana; Seung, David; Horrer, Daniel; Nigro, Arianna; Meier, Tiago; Zeeman, Samuel C.; Santelia, Diana

2016-01-01

Starch serves functions that range over a timescale of minutes to years, according to the cell type from which it is derived. In guard cells, starch is rapidly mobilized by the synergistic action of β-AMYLASE1 (BAM1) and α-AMYLASE3 (AMY3) to promote stomatal opening. In the leaves, starch typically accumulates gradually during the day and is degraded at night by BAM3 to support heterotrophic metabolism. During osmotic stress, starch is degraded in the light by stress-activated BAM1 to release sugar and sugar-derived osmolytes. Here, we report that AMY3 is also involved in stress-induced starch degradation. Recently isolated Arabidopsis thaliana amy3 bam1 double mutants are hypersensitive to osmotic stress, showing impaired root growth. amy3 bam1 plants close their stomata under osmotic stress at similar rates as the wild type but fail to mobilize starch in the leaves. 14C labeling showed that amy3 bam1 plants have reduced carbon export to the root, affecting osmolyte accumulation and root growth during stress. Using genetic approaches, we further demonstrate that abscisic acid controls the activity of BAM1 and AMY3 in leaves under osmotic stress through the AREB/ABF-SnRK2 kinase-signaling pathway. We propose that differential regulation and isoform subfunctionalization define starch-adaptive plasticity, ensuring an optimal carbon supply for continued growth under an ever-changing environment. PMID:27436713

Position of the American Dietetic Association: Providing nutrition services for people with developmental disabilities and special health care needs.

PubMed

Van Riper, Cynthia L; Wallace, Lee Shelly

2010-02-01

It is the position of the American Dietetic Association that nutrition services provided by registered dietitians (RDs) and dietetic technicians, registered (DTRs), are essential components of comprehensive care for all people with developmental disabilities and special health care needs. Nutrition services should be provided throughout life in a manner that is interdisciplinary, family-centered, community-based, and culturally competent. People with developmental disabilities and special health care needs frequently have nutrition concerns, including growth alterations (failure to thrive, obesity, or growth retardation), metabolic disorders, poor feeding skills, medication-nutrient interactions, and sometimes partial or total dependence on enteral or parenteral nutrition. Individuals with special needs are also more likely to develop comorbid conditions such as obesity or endocrine disorders that require nutrition interventions. Poor health habits, limited access to services, and long-term use of multiple medications are considered health risk factors. Health maintenance and avoidance of complications can be promoted by timely and cost-effective nutrition interventions. Public policy for individuals with special needs has evolved over time, resulting in a transition from institutional facilities and programs to community living. The expansion of public access to technology and health information on the Internet challenges RDs and DTRs to provide accurate scientific information for those with developmental disabilities and special health care needs. Nationally credentialed RDs and DTRs are best prepared to provide appropriate nutrition information for wellness and quality of life.

Understanding Inclusion and the Americans with Disabilities Act (ADA): A Resource To Assist Families, Child Care Providers and Advocates in Planning and Delivering Child Care for Children with Special Needs.

ERIC Educational Resources Information Center

2001

This booklet is designed to assist families, child care providers, and advocates in planning and delivering child care for children with disabilities and special health care needs. The booklet defines the term inclusion and discusses common misconceptions about children with special needs and disabilities. It explains what the Americans with…

The Proposed MACRA/MIPS Threshold for Patient-Facing Encounters: What It Means for Radiologists.

PubMed

Rosenkrantz, Andrew B; Hirsch, Joshua A; Allen, Bibb; Wang, Wenyi; Hughes, Danny R; Nicola, Gregory N

2017-03-01

In implementing the Merit-Based Incentive Payment System (MIPS), CMS will provide special considerations to physicians with infrequent face-to-face patient encounters by reweighting MIPS performance categories to account for the unique circumstances facing these providers. The aim of this study was to determine the impact of varying criteria on the fraction of radiologists who are likely to receive special considerations for performance assessment under MIPS. Data from the 2014 Medicare Physician and Other Supplier file for 28,710 diagnostic radiologists were used to determine the fraction of radiologists meeting various proposed criteria for receiving special considerations. For each definition, the fraction of patient-facing encounters among all billed codes was determined for those radiologists not receiving special considerations. When using the criterion proposed by CMS that physicians will receive special considerations if billing ≤25 evaluation and management services or surgical codes, 72.0% of diagnostic radiologists would receive special considerations, though such encounters would represent only 2.1% of billed codes among remaining diagnostic radiologists without special considerations. If CMS were to apply an alternative criterion of billing ≤100 evaluation and management codes exclusively, 98.8% of diagnostic radiologists would receive special considerations. At this threshold, patient-facing encounters would represent approximately 10% of billed codes among remaining radiologists without special considerations. The current CMS proposed criterion for special considerations would result in a considerable fraction of radiologists being evaluated on the basis of measures that are not reflective of their practice and beyond their direct control. Alternative criteria could help ensure that radiologists are provided a fair opportunity for success in performance review under the MIPS. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Respite care services for children with special healthcare needs: Parental perceptions.

PubMed

Whitmore, Kim E; Snethen, Julia

2018-04-26

Parents of children with special healthcare needs may become overwhelmed with the ongoing caregiving needs of their children. Caring for a child with special healthcare needs is often challenging, requiring specialized training in many cases. As a result, parents can struggle to find qualified caregivers capable of providing them a break from the 24/7 care of their child. Respite care programs are designed to provide caregivers with a much-needed temporary break. The purpose of this study was to examine parental perceptions of utilizing a respite care program. Twenty-two parents who had a child with special healthcare needs who attended a Midwestern respite care program completed a Participant Characteristic Form addressing their experiences caring for their child with special healthcare needs and using respite care services. Parents participated in a focus group (N = 4) to explore their perceptions and experiences of respite care participation. Multistage thematic analysis and descriptive statistics were used to analyze the data. Themes emerging from the data included: Constant care demands; It is just so stressful; Respite is a gift, we get a break; Respite program "fit"; and Respite is their special time too. Parents emphasized the benefits of respite care for their marital relationship, as well as the benefits to the children with special healthcare needs and their siblings. Parents also described the importance of tailoring respite care to the unique needs of their family. Nurses and other healthcare professionals play a critical role in addressing the unmet respite care needs of parents of children with special healthcare needs by identifying unmet needs and making appropriate referrals to services that will meet the unique needs of the family. Healthcare professionals can also volunteer with existing programs to help expand access to respite care services and increase the availability of adequately trained respite care providers whom parents can trust to provide for the complex healthcare needs of their children. © 2018 Wiley Periodicals, Inc.

2012 JSOU and NDIA SO/LIC Division Essays

DTIC Science & Technology

2012-07-01

University (JSOU) provides its publications to contribute toward expanding the body of knowledge about joint special operations. JSOU publications ...Comments about this publication are invited and should be forwarded to Director, Strategic Studies Department, Joint Special Operations University , 7701...Department of Defense, United States Special Operations Command, or the Joint Special Operations University . Recent Publications of the JSOU Press

12 CFR 1024.6 - Special information booklet at time of loan application.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Special information booklet at time of loan... SETTLEMENT PROCEDURES ACT (REGULATION X) § 1024.6 Special information booklet at time of loan application. (a) Lender to provide special information booklet. Subject to the exceptions set forth in this paragraph, the...

78 FR 20849 - Special Local Regulations; Marine Events, Potomac River; National Harbor Access Channel, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-08

...-AA08 Special Local Regulations; Marine Events, Potomac River; National Harbor Access Channel, MD AGENCY... special local regulations during the ``Swim Across the Potomac'' swimming competition, to be held on the waters of the Potomac River on June 2, 2013. These special local regulations are necessary to provide for...

29 CFR 35.16 - Special benefits for children and the elderly.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 1 2011-07-01 2011-07-01 false Special benefits for children and the elderly. 35.16... Discrimination § 35.16 Special benefits for children and the elderly. If a recipient is operating a program or activity that provides special benefits to the elderly or to children, the use of such age distinctions is...

45 CFR 91.17 - Special benefits for children and the elderly.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Special benefits for children and the elderly. 91... Standards for Determining Age Discrimination § 91.17 Special benefits for children and the elderly. If a recipient operating a program or activity provides special benefits to the elderly or to children, such use...

45 CFR 91.17 - Special benefits for children and the elderly.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Special benefits for children and the elderly. 91... Standards for Determining Age Discrimination § 91.17 Special benefits for children and the elderly. If a recipient operating a program or activity provides special benefits to the elderly or to children, such use...

76 FR 20840 - Medical Devices; General and Plastic Surgery Devices; Classification of the Low Level Laser...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-14

... into class II (special controls). The special control(s) that will apply to the device is entitled ``Class II Special Controls Guidance Document: Low Level Laser System for Aesthetic Use.'' The Agency is classifying the device into class II (special controls) in order to provide a reasonable assurance of safety...

Current Uses of Artificial Intelligence in Special Education. Abstract XI: Research & Resources on Special Education.

ERIC Educational Resources Information Center

ERIC Clearinghouse on Handicapped and Gifted Children, Reston, VA.

Summarized are two reports of a federally funded project on the use of artificial intelligence in special education. The first report, "Artificial Intelligence Applications in Special Education: How Feasible?," by Alan Hofmeister and Joseph Ferrara, provides information on the development and evaluation of a series of prototype systems in special…

The Development and Field Test of Employment Interview Questions Designed to Predict Special Education Teachers' Retention

ERIC Educational Resources Information Center

Vossler, Victoria L.

2010-01-01

The attrition of special education teachers greatly affects the quality of special education services districts can provide for students with disabilities and creates an ongoing challenge for educational leaders. It is essential to understand the factors influencing special education teachers' decisions to leave or remain in the field. If…

38 CFR 61.41 - Special need grants-application packages and threshold requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Special need grants-application packages and threshold requirements. 61.41 Section 61.41 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM Special Need Grants § 61.41 Special need...

38 CFR 61.41 - Special need grants-application packages and threshold requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Special need grants-application packages and threshold requirements. 61.41 Section 61.41 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM Special Need Grants § 61.41 Special need...

Project SCS (Special Communication Services).

ERIC Educational Resources Information Center

Curtis, John A.

This extensive report describes and provides documentation on Special Communications Services for the Sensory Impaired (SCS), a Virginia-based telecommunications delivery system developed by the Center for Excellence, Inc. (CenTex), to provide information and entertainment broadcasting services to the visually handicapped, the hearing impaired,…

American Academy of Pediatrics: Committee on Injury and Poison Prevention. School bus transportation of children with special health care needs.

PubMed

2001-08-01

School systems are responsible for ensuring that children with special needs are safely transported on all forms of federally approved transportation provided by the school system, and a plan should be developed to provide the most current and proper support to children with special transportation requirements. This statement provides current guidelines for the protection of child passengers with specific health care needs, including those with a tracheostomy, those requiring use of car seats, or those transported in wheelchairs. Guidelines that apply to general school transportation should be followed, including the training of staff, provision of nurses or aides if needed, establishment of a written emergency evacuation plan, and a comprehensive infection control program. Research provides the basis for recommendations concerning occupant securement for children in wheelchairs and children with other special needs who are transported on a school bus. Pediatricians can help their patients by being aware of guidelines for restraint systems for children with special needs and by remaining informed of new resources. Pediatricians can also play an important role at the state and local level in the development of school bus specifications.

School Bus Transportation of Children With Special Health Care Needs.

PubMed

O'Neil, Joseph; Hoffman, Benjamin D

2018-05-01

School systems are responsible for ensuring that children with special needs are safely transported on all forms of federally approved transportation provided by the school system. A plan to provide the most current and proper support to children with special transportation needs should be developed by the Individualized Education Program team, including the parent, school transportation director, and school nurse, in conjunction with physician orders and recommendations. With this statement, we provide current guidance for the protection of child passengers with specific health care needs. Guidance that applies to general school transportation should be followed, inclusive of staff training, provision of nurses or aides if needed, and establishment of a written emergency evacuation plan as well as a comprehensive infection control program. Researchers provide the basis for recommendations concerning occupant securement for children in wheelchairs and children with other special needs who are transported on a school bus. Pediatricians can help their patients by being aware of guidance for restraint systems for children with special needs and by remaining informed of new resources. Pediatricians can also play an important role at the state and local level in the development of school bus specifications. Copyright © 2018 by the American Academy of Pediatrics.

The Other Quiet Professionals: Lessons for Future Cyber Forces from the Evolution of Special Forces

DTIC Science & Technology

2014-01-01

Special Forces, Rangers, civil affairs, and psychological operations units—under the new command. Furthermore, the army provided Special Forces with...and 10th Special Forces (Airborne) groups; the 4th Psychological Operations Group, 96th Civil Affairs Battalion; the 75th Ranger Regiment; the 160th...and reserve psychological operations and civil affairs units. Similarly, the Navy sought to withhold U.S. Naval Special Warfare forces, arguing that

Perceptions of Special Education Teachers Regarding Documentation of Individual Special Education Student Academic Accommodations within Secondary Inclusion Classrooms in an Identified Rural Public School District in Sussex County, Delaware

ERIC Educational Resources Information Center

Conover, Virginia Ann

2010-01-01

The purpose of this qualitative study was to determine special education teachers' perceptions of the daily process of documentation of academic accommodations provided to special education students on their caseloads, Grades 6-10. The purposefully selected sample was comprised of 12 middle and high school special education teachers who teach in…

Meeting Our Responsibilities in Special Education.

ERIC Educational Resources Information Center

LeRoy, C. H.; And Others

1994-01-01

This paper reviews transmission of human immunodeficiency virus and stages of acquired immune deficiency syndrome (AIDS); AIDS symptoms in children; special complications for children with disabilities; and responsibilities of special educators, including, among others, inclusion in schools, interdisciplinary team management, providing a family…

The Concept of Respite Care.

PubMed

Whitmore, Kim E

2017-07-01

The aim of this article is to analyze the concept of respite care in the context of caring for a child with special healthcare needs. Respite care has often been identified as an important resource for caregivers of children with special healthcare needs. It can help provide a break from the constant demands of caregiving. A concept analysis was conducted using an evolutionary approach. The data source for the concept analysis was a review of literature addressing respite care for caregivers of children with special healthcare needs. A review of the literature was conducted and a concept model was developed using an evolutionary approach. A theoretical definition of respite care is provided and the defining attributes, related concepts, antecedents, and consequences of respite care are shown in a diagram of the concept of respite care. The conceptual model provides a framework to help nurses better understand the concept of respite care in order to educate caregivers, provide appropriate referrals, serve as providers of respite care, and advocate for policy changes related to the provision of respite care services for caregivers of children with special healthcare needs. © 2016 Wiley Periodicals, Inc.

Fixing Special Education

ERIC Educational Resources Information Center

Greene, Jay P.

2007-01-01

The current system of educating disabled students provides financial incentives to schools to overidentify students as disabled and underserve those that are identified. The incentive to overidentify is caused by providing schools with additional funds as more students are placed in special education categories that are ambiguous to diagnose and…

Procedures and criteria for increasing the earthquake resistance level of electrical substations and special installations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Couch, R.W.; Deacon, R.J.

1973-09-30

This report defines a procedure and provides basic information needed to determine the modifications required to make electrical substations and special installations of the Bonneville Power Administration (BPA) more resistant to strong earthquake ground motion. It also provides a procedure for developing an effective plan for establishing the sequence, or priority, of providing the required modifications.

Health Professionals Special Pays Study: Report to Congress on Armed Forces Health Professionals Special Pays -- Other Health Care Providers

DTIC Science & Technology

1988-12-01

of its force in those years, while others were able to maintain their size fairly well. Various factors have contributed to the relative health of each...specialized health care providers. These factors have particular significance for health care in the Military Health Services System (MHSS). The Military...system. Many factors interrelate to cause major changes in health care delivery since the early 1970s. And health care is continuing to evolve as a result

Special nuclear material simulation device

DOEpatents

Leckey, John H.; DeMint, Amy; Gooch, Jack; Hawk, Todd; Pickett, Chris A.; Blessinger, Chris; York, Robbie L.

2014-08-12

An apparatus for simulating special nuclear material is provided. The apparatus typically contains a small quantity of special nuclear material (SNM) in a configuration that simulates a much larger quantity of SNM. Generally the apparatus includes a spherical shell that is formed from an alloy containing a small quantity of highly enriched uranium. Also typically provided is a core of depleted uranium. A spacer, typically aluminum, may be used to separate the depleted uranium from the shell of uranium alloy. A cladding, typically made of titanium, is provided to seal the source. Methods are provided to simulate SNM for testing radiation monitoring portals. Typically the methods use at least one primary SNM spectral line and exclude at least one secondary SNM spectral line.

Do You Want to Make a Difference in the Lives of Students with Special Needs? Careers in Special Education and Related Services.

ERIC Educational Resources Information Center

National Clearinghouse for Professions in Special Education, Reston, VA.

Designed for high school students interested in careers in special education and related services, this guide outlines the different roles of special education and related services professionals who teach and provide specifically designed instruction and services to children with disabilities. It addresses the different disabilities that students…

Everyday Arts for Special Education Impact Evaluation. District 75, New York City Department of Education

ERIC Educational Resources Information Center

Horowitz, Rob

2016-01-01

The purpose of this study was to examine the impact of the Everyday Arts for Special Education (EASE) program on elementary special education students' academic achievement (reading and math) and social-emotional learning. EASE was a 5-year program providing professional development and instruction in the arts in 10 New York City special education…

29 CFR 35.16 - Special benefits for children and the elderly.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Special benefits for children and the elderly. 35.16 Section... Discrimination § 35.16 Special benefits for children and the elderly. If a recipient is operating a program or activity that provides special benefits to the elderly or to children, the use of such age distinctions is...

What Every Special Educator Must Know: The International Standards for the Preparation and Certification of Special Education Teachers. Second Edition.

ERIC Educational Resources Information Center

Council for Exceptional Children, Reston, VA.

This document presents revised comprehensive standards and guidelines for the preparation and certification of special educators and for practice as special educators, developed by the Council for Exceptional Children (CEC). Part 1 provides the CEC's Code of Ethics for Professional Practice for Educators of Persons with Exceptionalities and CEC's…

75 FR 34634 - Special Local Regulation; Swim Across the Sound, Long Island Sound, Port Jefferson, NY to Captain...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

...-AA08 Special Local Regulation; Swim Across the Sound, Long Island Sound, Port Jefferson, NY to Captain... Guard is establishing a permanent Special Local Regulation on the navigable waters of Long Island Sound... Sound event. This special local regulation is necessary to provide for the safety of life by protecting...

40 CFR 435.51 - Specialized definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Specialized definitions. 435.51 Section 435.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES... Subcategory § 435.51 Specialized definitions. For the purpose of this subpart: (a) Except as provided below...

40 CFR 418.31 - Specialized definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 29 2011-07-01 2009-07-01 true Specialized definitions. 418.31 Section... STANDARDS FERTILIZER MANUFACTURING POINT SOURCE CATEGORY Urea Subcategory § 418.31 Specialized definitions. For the purposes of this subpart: (a) Except as provided below, the general definitions, abbreviations...

Evolutionary Expansion of WRKY Gene Family in Banana and Its Expression Profile during the Infection of Root Lesion Nematode, Pratylenchus coffeae.

PubMed

Kaliyappan, Raja; Viswanathan, Sriram; Suthanthiram, Backiyarani; Subbaraya, Uma; Marimuthu Somasundram, Saraswathi; Muthu, Mayilvaganan

2016-01-01

The WRKY family of transcription factors orchestrate the reprogrammed expression of the complex network of defense genes at various biotic and abiotic stresses. Within the last 96 million years, three rounds of Musa polyploidization events had occurred from selective pressure causing duplication of MusaWRKYs with new activities. Here, we identified a total of 153 WRKY transcription factors available from the DH Pahang genome. Based on their phylogenetic relationship, the MusaWRKYs available with complete gene sequence were classified into the seven common WRKY sub-groups. Synteny analyses data revealed paralogous relationships, with 17 MusaWRKY gene pairs originating from the duplication events that had occurred within the Musa lineage. We also found 15 other MusaWRKY gene pairs originating from much older duplication events that had occurred along Arecales and Poales lineage of commelinids. Based on the synonymous and nonsynonymous substitution rates, the fate of duplicated MusaWRKY genes was predicted to have undergone sub-functionalization in which the duplicated gene copies retain a subset of the ancestral gene function. Also, to understand the regulatory roles of MusaWRKY during a biotic stress, Illumina sequencing was performed on resistant and susceptible cultivars during the infection of root lesion nematode, Pratylenchus coffeae. The differential WRKY gene expression analysis in nematode resistant and susceptible cultivars during challenged and unchallenged conditions had distinguished: 1) MusaWRKYs participating in general banana defense mechanism against P.coffeae common to both susceptible and resistant cultivars, 2) MusaWRKYs that may aid in the pathogen survival as suppressors of plant triggered immunity, 3) MusaWRKYs that may aid in the host defense as activators of plant triggered immunity and 4) cultivar specific MusaWRKY regulation. Mainly, MusaWRKY52, -69 and -92 are found to be P.coffeae specific and can act as activators or repressors in a defense pathway. Overall, this preliminary study in Musa provides the basis for understanding the evolution and regulatory mechanism of MusaWRKY during nematode stress.

Evolutionary Expansion of WRKY Gene Family in Banana and Its Expression Profile during the Infection of Root Lesion Nematode, Pratylenchus coffeae

PubMed Central

Suthanthiram, Backiyarani; Subbaraya, Uma; Marimuthu Somasundram, Saraswathi; Muthu, Mayilvaganan

2016-01-01

The WRKY family of transcription factors orchestrate the reprogrammed expression of the complex network of defense genes at various biotic and abiotic stresses. Within the last 96 million years, three rounds of Musa polyploidization events had occurred from selective pressure causing duplication of MusaWRKYs with new activities. Here, we identified a total of 153 WRKY transcription factors available from the DH Pahang genome. Based on their phylogenetic relationship, the MusaWRKYs available with complete gene sequence were classified into the seven common WRKY sub-groups. Synteny analyses data revealed paralogous relationships, with 17 MusaWRKY gene pairs originating from the duplication events that had occurred within the Musa lineage. We also found 15 other MusaWRKY gene pairs originating from much older duplication events that had occurred along Arecales and Poales lineage of commelinids. Based on the synonymous and nonsynonymous substitution rates, the fate of duplicated MusaWRKY genes was predicted to have undergone sub-functionalization in which the duplicated gene copies retain a subset of the ancestral gene function. Also, to understand the regulatory roles of MusaWRKY during a biotic stress, Illumina sequencing was performed on resistant and susceptible cultivars during the infection of root lesion nematode, Pratylenchus coffeae. The differential WRKY gene expression analysis in nematode resistant and susceptible cultivars during challenged and unchallenged conditions had distinguished: 1) MusaWRKYs participating in general banana defense mechanism against P.coffeae common to both susceptible and resistant cultivars, 2) MusaWRKYs that may aid in the pathogen survival as suppressors of plant triggered immunity, 3) MusaWRKYs that may aid in the host defense as activators of plant triggered immunity and 4) cultivar specific MusaWRKY regulation. Mainly, MusaWRKY52, -69 and -92 are found to be P.coffeae specific and can act as activators or repressors in a defense pathway. Overall, this preliminary study in Musa provides the basis for understanding the evolution and regulatory mechanism of MusaWRKY during nematode stress. PMID:27603787

Molecular evolution and transcriptional regulation of the oilseed rape proline dehydrogenase genes suggest distinct roles of proline catabolism during development.

PubMed

Faës, Pascal; Deleu, Carole; Aïnouche, Abdelkader; Le Cahérec, Françoise; Montes, Emilie; Clouet, Vanessa; Gouraud, Anne-Marie; Albert, Benjamin; Orsel, Mathilde; Lassalle, Gilles; Leport, Laurent; Bouchereau, Alain; Niogret, Marie-Françoise

2015-02-01

Six BnaProDH1 and two BnaProDH2 genes were identified in Brassica napus genome. The BnaProDH1 genes are mainly expressed in pollen and roots' organs while BnaProDH2 gene expression is associated with leaf vascular tissues at senescence. Proline dehydrogenase (ProDH) catalyzes the first step in the catabolism of proline. The ProDH gene family in oilseed rape (Brassica napus) was characterized and compared to other Brassicaceae ProDH sequences to establish the phylogenetic relationships between genes. Six BnaProDH1 genes and two BnaProDH2 genes were identified in the B. napus genome. Expression of the three paralogous pairs of BnaProDH1 genes and the two homoeologous BnaProDH2 genes was measured by real-time quantitative RT-PCR in plants at vegetative and reproductive stages. The BnaProDH2 genes are specifically expressed in vasculature in an age-dependent manner, while BnaProDH1 genes are strongly expressed in pollen grains and roots. Compared to the abundant expression of BnaProDH1, the overall expression of BnaProDH2 is low except in roots and senescent leaves. The BnaProDH1 paralogs showed different levels of expression with BnaA&C.ProDH1.a the most strongly expressed and BnaA&C.ProDH1.c the least. The promoters of two BnaProDH1 and two BnaProDH2 genes were fused with uidA reporter gene (GUS) to characterize organ and tissue expression profiles in transformed B. napus plants. The transformants with promoters from different genes showed contrasting patterns of GUS activity, which corresponded to the spatial expression of their respective transcripts. ProDHs probably have non-redundant functions in different organs and at different phenological stages. In terms of molecular evolution, all BnaProDH sequences appear to have undergone strong purifying selection and some copies are becoming subfunctionalized. This detailed description of oilseed rape ProDH genes provides new elements to investigate the function of proline metabolism in plant development.

Natural history of SLC11 genes in vertebrates: tales from the fish world.

PubMed

Neves, João V; Wilson, Jonathan M; Kuhl, Heiner; Reinhardt, Richard; Castro, L Filipe C; Rodrigues, Pedro N S

2011-04-18

The SLC11A1/Nramp1 and SLC11A2/Nramp2 genes belong to the SLC11/Nramp family of transmembrane divalent metal transporters, with SLC11A1 being associated with resistance to pathogens and SLC11A2 involved in intestinal iron uptake and transferrin-bound iron transport. Both members of the SLC11 gene family have been clearly identified in tetrapods; however SLC11A1 has never been documented in teleost fish and is believed to have been lost in this lineage during early vertebrate evolution. In the present work we characterized the SLC11 genes in teleosts and evaluated if the roles attributed to mammalian SLC11 genes are assured by other fish specific SLC11 gene members. Two different SLC11 genes were isolated in the European sea bass (Dicentrarchus. labrax), and named slc11a2-α and slc11a2-β, since both were found to be evolutionary closer to tetrapods SLC11A2, through phylogenetic analysis and comparative genomics. Induction of slc11a2-α and slc11a2-β in sea bass, upon iron modulation or exposure to Photobacterium damselae spp. piscicida, was evaluated in in vivo or in vitro experimental models. Overall, slc11a2-α was found to respond only to iron deficiency in the intestine, whereas slc11a2-β was found to respond to iron overload and bacterial infection in several tissues and also in the leukocytes. Our data suggests that despite the absence of slc11a1, its functions have been undertaken by one of the slc11a2 duplicated paralogs in teleost fish in a case of synfunctionalization, being involved in both iron metabolism and response to bacterial infection. This study provides, to our knowledge, the first example of this type of sub-functionalization in iron metabolism genes, illustrating how conserving the various functions of the SLC11 gene family is of crucial evolutionary importance.

Restriction of Equine Infectious Anemia Virus by Equine APOBEC3 Cytidine Deaminases ▿ †

PubMed Central

Zielonka, Jörg; Bravo, Ignacio G.; Marino, Daniela; Conrad, Elea; Perković, Mario; Battenberg, Marion; Cichutek, Klaus; Münk, Carsten

2009-01-01

The mammalian APOBEC3 (A3) proteins comprise a multigene family of cytidine deaminases that act as potent inhibitors of retroviruses and retrotransposons. The A3 locus on the chromosome 28 of the horse genome contains multiple A3 genes: two copies of A3Z1, five copies of A3Z2, and a single copy of A3Z3, indicating a complex evolution of multiple gene duplications. We have cloned and analyzed for expression the different equine A3 genes and examined as well the subcellular distribution of the corresponding proteins. Additionally, we have tested the functional antiretroviral activity of the equine and of several of the human and nonprimate A3 proteins against the Equine infectious anemia virus (EIAV), the Simian immunodeficiency virus (SIV), and the Adeno-associated virus type 2 (AAV-2). Hematopoietic cells of horses express at least five different A3s: A3Z1b, A3Z2a-Z2b, A3Z2c-Z2d, A3Z2e, and A3Z3, whereas circulating macrophages, the natural target of EIAV, express only part of the A3 repertoire. The five A3Z2 tandem copies arose after three consecutive, recent duplication events in the horse lineage, after the split between Equidae and Carnivora. The duplicated genes show different antiviral activities against different viruses: equine A3Z3 and A3Z2c-Z2d are potent inhibitors of EIAV while equine A3Z1b, A3Z2a-Z2b, A3Z2e showed only weak anti-EIAV activity. Equine A3Z1b and A3Z3 restricted AAV and all equine A3s, except A3Z1b, inhibited SIV. We hypothesize that the horse A3 genes are undergoing a process of subfunctionalization in their respective viral specificities, which might provide the evolutionary advantage for keeping five copies of the original gene. PMID:19458006

34 CFR 304.23 - Assurances that must be provided by grantee.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SERVICE OBLIGATIONS UNDER SPECIAL EDUCATION-PERSONNEL DEVELOPMENT TO IMPROVE SERVICES AND RESULTS FOR CHILDREN WITH DISABILITIES Conditions... 34 Education 2 2011-07-01 2010-07-01 true Assurances that must be provided by grantee. 304.23...

34 CFR 304.23 - Assurances that must be provided by grantee.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SERVICE OBLIGATIONS UNDER SPECIAL EDUCATION-PERSONNEL DEVELOPMENT TO IMPROVE SERVICES AND RESULTS FOR CHILDREN WITH DISABILITIES Conditions... 34 Education 2 2010-07-01 2010-07-01 false Assurances that must be provided by grantee. 304.23...

The Law and Special Education.

ERIC Educational Resources Information Center

Yell, Mitchell L.

This textbook provides information on the legal development of special education, the current legal requirements in providing a free appropriate public education to students with disabilities, and the procedures involved in obtaining legal information in law libraries and on the Internet. Specifically, the 16 chapters address: (1) sources of law…

Special care dentistry for general dental practice.

PubMed

Greig, Vicki; Sweeney, Petrina

2013-01-01

Although special care dentistry (SCD) is a fairly recent specialty, the principles and practice of SCD have been developed since the 1980s. Shared care of these patients with general dental practitioners remains vital to ensure that comprehensive care is provided. This article aims to discuss some of the patient groups commonly seen in SCD clinics and give an insight into the varied complex medical and social aspects of care which are managed as part of providing appropriate, safe and holistic care. Many patients who currently fall under the remit of special care dentistry could be treated safely in general dental practice. This article acts as an introduction to special care dentistry for general dental practitioners.

Distinguishing Disability: Parents, Privilege, and Special Education

ERIC Educational Resources Information Center

Ong-Dean, Colin

2009-01-01

Students in special education programs can have widely divergent experiences. For some, special education amounts to a dumping ground where schools unload their problem students, while for others, it provides access to services and accommodations that drastically improve chances of succeeding in school and beyond. "Distinguishing…

Special Projects: An Historical Analysis.

ERIC Educational Resources Information Center

Thomas, M. Angele; Bunsen, Teresa D.

The Special Projects Competition is a separate federal government priority authorized to support an increased quantity and improved quality of personnel available to educate infants, toddlers, children, and youth with disabilities. Special project grants provide a means for the conceptualization of new approaches to preparation programs, the…

28 CFR 42.714 - Special benefits.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Special benefits. 42.714 Section 42.714 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION; EQUAL EMPLOYMENT OPPORTUNITY; POLICIES AND... benefits. If a recipient operating a program or activity provides special benefits to the elderly or to...

28 CFR 42.714 - Special benefits.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Special benefits. 42.714 Section 42.714 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION; EQUAL EMPLOYMENT OPPORTUNITY; POLICIES AND... benefits. If a recipient operating a program or activity provides special benefits to the elderly or to...

28 CFR 42.714 - Special benefits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Special benefits. 42.714 Section 42.714 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION; EQUAL EMPLOYMENT OPPORTUNITY; POLICIES AND... benefits. If a recipient operating a program or activity provides special benefits to the elderly or to...

28 CFR 42.714 - Special benefits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Special benefits. 42.714 Section 42.714 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION; EQUAL EMPLOYMENT OPPORTUNITY; POLICIES AND... benefits. If a recipient operating a program or activity provides special benefits to the elderly or to...

42 CFR 489.26 - Special requirements concerning veterans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Special requirements concerning veterans. 489.26... Provider Agreements § 489.26 Special requirements concerning veterans. For inpatient services, a hospital... concerning admissions practices and payment methodology and amounts. This section applies to services...

Special Education in Arab Countries: Current Challenges

ERIC Educational Resources Information Center

Hadidi, Muna S.; Al Khateeb, Jamal M.

2015-01-01

Arab countries have undertaken various measures to develop special education programmes and services over the last three decades; nevertheless, major challenges remain regarding the expansion of these programmes and services and improving their quality. "This article provides an update on disability and special education in Arab…

Special Education Research Advances Knowledge in Education

ERIC Educational Resources Information Center

Vaughn, Sharon; Swanson, Elizabeth A.

2015-01-01

Research in special education has yielded beneficial outcomes for students with disabilities as well as typical achieving students. The authors provide examples of the valuable knowledge special education research has generated, including the elements of response to intervention (e.g., screening and progress monitoring), instructional practices…

40 CFR 435.51 - Specialized definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Specialized definitions. 435.51... AND STANDARDS OIL AND GAS EXTRACTION POINT SOURCE CATEGORY Agricultural and Wildlife Water Use Subcategory § 435.51 Specialized definitions. For the purpose of this subpart: (a) Except as provided below...

36 CFR 2.50 - Special events.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Special events. 2.50 Section... PROTECTION, PUBLIC USE AND RECREATION § 2.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however, There...

36 CFR 2.50 - Special events.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Special events. 2.50 Section... PROTECTION, PUBLIC USE AND RECREATION § 2.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however, There...

36 CFR 2.50 - Special events.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Special events. 2.50 Section... PROTECTION, PUBLIC USE AND RECREATION § 2.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however, There...

36 CFR 1002.50 - Special events.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Special events. 1002.50... RECREATION § 1002.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however, There is a meaningful association...

36 CFR 2.50 - Special events.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Special events. 2.50 Section... PROTECTION, PUBLIC USE AND RECREATION § 2.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however, There...

36 CFR 1002.50 - Special events.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Special events. 1002.50... RECREATION § 1002.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however, There is a meaningful association...

36 CFR 2.50 - Special events.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Special events. 2.50 Section... PROTECTION, PUBLIC USE AND RECREATION § 2.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however, There...

West Asian Special Libraries and Information Centers.

ERIC Educational Resources Information Center

Harvey, John F.

Special libraries are defined in this paper as those libraries serving such institutions as government offices, private corporations, associations, and university departments. Information centers are similar to special libraries but provide personalized, high quality reference service, usually in science and technology, and often using mechanical…

Minority Recruitment and Retention for Universities: Bilingual Special Education Faculty

ERIC Educational Resources Information Center

Brice, Alejandro E.

2012-01-01

Recruitment and retention of minority faculty in bilingual special education is a perilous task. Research has shown that minority faculty/teachers are able to provide emotional support, mentor students, serve as role models, create a positive climate, provide diverse views, increase collaboration among faculty and teachers, and work with…

75 FR 30410 - Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Provider...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

..., Disability, and Injury Prevention and Control Special Interest Project (SIP): Provider and Public Health... and Public Health Input for Vaccine Policy Decisions, SIP 10-036.'' Contact Person for More Information: Michelle Mathieson, Public Health Analyst, National Center for Chronic Disease and Health...

Inservice Packet Undertaken for the Vocational Assessment for Special Needs Project.

ERIC Educational Resources Information Center

Hemphill, Norma Jean

The inservice package for assessment team members is designed to provide skill training regarding the vocational assessment process used with special needs students. Activities within the inservice training package sensitize individuals to the purposes of infusing vocational assessment into the educational curriculum, and provide instruction on…

41 CFR 102-85.195 - Does GSA provide special services?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does GSA provide special services? 102-85.195 Section 102-85.195 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 85-PRICING POLICY FOR...

Multimedia Centers: Concepts for the Future.

ERIC Educational Resources Information Center

Crannell, Philip A.

Because of public demand for access to new media, librarians must be able to provide specialized systems and facilities. To support librarians in the planning and rethinking of new multimedia libraries, the firm of Gee & Jenson, which specializes in library design, created this guide. It provides an illustration of the possibilities and…

34 CFR 606.23 - What special funding consideration does the Secretary provide?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What special funding consideration does the Secretary provide? 606.23 Section 606.23 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION DEVELOPING HISPANIC-SERVING...

34 CFR 606.23 - What special funding consideration does the Secretary provide?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What special funding consideration does the Secretary provide? 606.23 Section 606.23 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION DEVELOPING HISPANIC-SERVING...

Computer-Based Education. The Best of ERIC, 1988.

ERIC Educational Resources Information Center

McLaughlin, Pamela

This annotated bibliography provides an overview of literature entered into the ERIC database in 1988 on computer use in elementary and secondary education, adult education, and special education. The first of four sections provides a list of overview documents on: computer-assisted instruction. Focusing on special applications, the second section…

Relationships between Working Conditions and Special Educators' Instruction

ERIC Educational Resources Information Center

Bettini, Elizabeth A.; Crockett, Jean B.; Brownell, Mary T.; Merrill, Kristen L.

2016-01-01

Students with disabilities (SWDs) depend upon special education teachers (SETs) to provide effective instruction. SETs, in turn, depend upon school leaders to provide conditions necessary to learn and engage in effective instructional practices for students with the most significant learning needs. A promising body of research indicates that…

A Personal Appraisal of the MIBiol Courses in Entomology and Plant Pathology at Wolverhampton Polytechnic, 1967-71

ERIC Educational Resources Information Center

Ayerst, G.; Gower, A. M.

1972-01-01

Article provides brief description of two microbiology courses at the college level which have multiple characteristics. Course I provides instruction based on papers in biology and in a special subject. Course II is devoted entirely to the special subject. (PS)

Training and Resource Needs of Teachers Who Provide HIV Education to Special Population Students

ERIC Educational Resources Information Center

Sawyer, Richard J.; Blake, Susan; Ledsky, Rebecca; Goodenow, Carol; Evans, Doug

2004-01-01

This study identified substantial training and resource needs for special education (SPED), transitional bilingual education/ English as a Second Language (TBE/ESL), and general education (GENED) HIV education teachers relative to providing appropriate, effective HIV education to students with disabilities (SWD) and language minority/Limited…

42 CFR 422.214 - Special rules for services furnished by noncontract providers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules for services furnished by noncontract providers. 422.214 Section 422.214 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Relationships With...

Marine Special Operations Helicopter Unit: Viability in the Joint Force of 2020

DTIC Science & Technology

2012-04-18

competitive globalized environment will increase the requirements for aviation support. With a dedicated Marine Special Operations Helicopter Squadron...efficiency in planning, training, and execution will provide for precise timely and accurate organic fires, direct mobility support, and reduce the...Fulfilling the gap in Marine Special Operations Command with a dedicated Marine special operations helicopter unit is necessary. Concisely, this will

Strategic Choice: United States Special Forces’ Comparative Advantage in Irregular Warfare

DTIC Science & Technology

2017-03-01

UNITED STATES SPECIAL FORCES’ COMPARATIVE ADVANTAGE IN IRREGULAR WARFARE by Steven F. Payne March 2017 Thesis Advisor: Hy S. Rothstein...REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE STRATEGIC CHOICE: UNITED STATES SPECIAL FORCES’ COMPARATIVE ADVANTAGE IN...methodology, this thesis concludes that U.S. Army Special Forces have a comparative advantage over conventional forces to provide the National Command

34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

Code of Federal Regulations, 2012 CFR

2012-07-01

... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to § 403.32...

34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

Code of Federal Regulations, 2013 CFR

2013-07-01

... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to § 403.32...

34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

Code of Federal Regulations, 2011 CFR

2011-07-01

... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to § 403.32...

34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

Code of Federal Regulations, 2014 CFR

2014-07-01

... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to § 403.32...

Assessment of Classroom Verbal Interaction and Attitudes toward School for Female Students in Single-Gender and Mixed-Gender Residential Special Education Classes

ERIC Educational Resources Information Center

Marcik-Mc Closkey, Nicole J.

2009-01-01

The education of students with special needs is an area which continues to evolve as teachers and administrators strive to provide the most appropriate learning environment for children. A paucity of information exists regarding the needs of female students in special education. This study compared female students with special needs at two…

Strategies and Techniques for Mainstreaming. Revised.

ERIC Educational Resources Information Center

Scheetz, Janet A.; Hudak, Barbara J.

The handbook is intended for the special education teacher and covers all aspects of mainstreaming according to the Monroe model, developed in Monroe County, Michigan. The model focuses on the special education teacher/consultant, who provides direct diagnostic and instructional services to special students, and indirect services to building…

Special Education in Early Childhood. A Burning Issues Series Report.

ERIC Educational Resources Information Center

San Diego County Office of Education, CA.

The National Preschool Coordination Project's (NPCP) Interstate Coordination Committee identified problems in finding and providing special education services for preschool migrant children. They propose training for parents and migrant staff and coordination among agencies to improve services. The NPCP Subcommittee on Special Education identified…

Completing the Special Education J-50 Report.

ERIC Educational Resources Information Center

California Association of School Business Officials, Sacramento.

The J-50 Report, one of the most complicated entitlement reports that any state agency requires, provides information for funding and monitoring special education services and operations throughout California and for making special education funding allocations equitable. This manual was developed to assist local educational agency (LEA) and…

39 CFR 122.1 - Ancillary special services.

Code of Federal Regulations, 2010 CFR

2010-07-01

... mail products identified above in part 121, mailers may purchase various ancillary special services... by the Postal Service on mail for which the following special services have been purchased: Domestic... purchase insurance from the Postal ServiceTM to provide indemnity against loss or damage to the contents of...

A service-learning project to eliminate barriers to oral care for children with special health care needs.

PubMed

DeMattei, Ronda R; Allen, Jessica; Goss, Breanna

2012-06-01

Children with special health care needs face many barriers to oral care and are at high risk for oral disease. School nurses are in a unique position to promote oral wellness in this vulnerable population. Collaboration between school nurses and dental hygiene faculty resulted in the formation of a partnership between a university-based dental hygiene program and two special education districts in rural southern Illinois. Senior dental hygiene students participated in a school-based service-learning project that provided dental examinations, preventive services, and education to children with special health care needs. Evidence-based behavioral interventions were used to teach children to comply with oral procedures. School nurses mentored dental hygiene students in behavior management of children. Dental exams were provided to 234 children from four special education schools with the majority receiving cleanings and fluoride.

Model of Providing Assistive Technologies in Special Education Schools.

PubMed

Lersilp, Suchitporn; Putthinoi, Supawadee; Chakpitak, Nopasit

2015-05-14

Most students diagnosed with disabilities in Thai special education schools received assistive technologies, but this did not guarantee the greatest benefits. The purpose of this study was to survey the provision, use and needs of assistive technologies, as well as the perspectives of key informants regarding a model of providing them in special education schools. The participants were selected by the purposive sampling method, and they comprised 120 students with visual, physical, hearing or intellectual disabilities from four special education schools in Chiang Mai, Thailand; and 24 key informants such as parents or caregivers, teachers, school principals and school therapists. The instruments consisted of an assistive technology checklist and a semi-structured interview. Results showed that a category of assistive technologies was provided for students with disabilities, with the highest being "services", followed by "media" and then "facilities". Furthermore, mostly students with physical disabilities were provided with assistive technologies, but those with visual disabilities needed it more. Finally, the model of providing assistive technologies was composed of 5 components: Collaboration; Holistic perspective; Independent management of schools; Learning systems and a production manual for users; and Development of an assistive technology center, driven by 3 major sources such as Government and Private organizations, and Schools.

47 CFR 15.27 - Special accessories.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 1 2013-10-01 2013-10-01 false Special accessories. 15.27 Section 15.27 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.27 Special... manual is provided only in a form other than paper, such as on a computer disk or over the Internet, the...

47 CFR 15.27 - Special accessories.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false Special accessories. 15.27 Section 15.27 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.27 Special... manual is provided only in a form other than paper, such as on a computer disk or over the Internet, the...

47 CFR 15.27 - Special accessories.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 1 2014-10-01 2014-10-01 false Special accessories. 15.27 Section 15.27 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.27 Special... manual is provided only in a form other than paper, such as on a computer disk or over the Internet, the...

47 CFR 15.27 - Special accessories.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 1 2011-10-01 2011-10-01 false Special accessories. 15.27 Section 15.27 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.27 Special... manual is provided only in a form other than paper, such as on a computer disk or over the Internet, the...

Preparing Urban Special Education Leaders: What Works

ERIC Educational Resources Information Center

Martin, Suzanne M.; Little, Joyce; Miller, Katie; Gourwitz, Jillian

2014-01-01

Special education administrators play a critical role in the implementation of successful inclusion in diverse, standards-based environments. They provide the vision and leadership necessary to guide educators in both general and special education as they deliver instructional programs to meet the needs of diverse students with disabilities.…

Hiring an Effective Special Education Teacher

ERIC Educational Resources Information Center

Fenlon, Amanda

2008-01-01

The task of hiring special education teachers may seem daunting because they serve in what is undeniably the most complex of teaching roles. This article provides guidance and suggestions for identifying key competencies that a viable special education teacher candidate should possess. Although many building leaders may still subscribe to gut…

Webcasting: A New Technology for Training Special Educators in Rural Areas.

ERIC Educational Resources Information Center

Ludlow, Barbara L.; Duff, Michael C.

This paper describes the use of webcasting technology in a personnel preparation program for rural special education practitioners. Emerging technologies offer promising solutions to the challenges of providing accessible and appropriate training to rural special educators. Web-based instruction is especially appropriate for on-the-job training of…

42 CFR 489.28 - Special capitalization requirements for HHAs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Special capitalization requirements for HHAs. 489.28 Section 489.28 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND... Essentials of Provider Agreements § 489.28 Special capitalization requirements for HHAs. (a) Basic rule. An...

33 CFR 109.10 - Special anchorage areas.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Special anchorage areas. 109.10 Section 109.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES GENERAL § 109.10 Special anchorage areas. An Act of Congress of April 22, 1940, provides for the...

33 CFR 109.10 - Special anchorage areas.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Special anchorage areas. 109.10 Section 109.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES GENERAL § 109.10 Special anchorage areas. An Act of Congress of April 22, 1940, provides for the...

33 CFR 109.10 - Special anchorage areas.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Special anchorage areas. 109.10 Section 109.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES GENERAL § 109.10 Special anchorage areas. An Act of Congress of April 22, 1940, provides for the...

33 CFR 109.10 - Special anchorage areas.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Special anchorage areas. 109.10 Section 109.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES GENERAL § 109.10 Special anchorage areas. An Act of Congress of April 22, 1940, provides for the...

33 CFR 109.10 - Special anchorage areas.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Special anchorage areas. 109.10 Section 109.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES GENERAL § 109.10 Special anchorage areas. An Act of Congress of April 22, 1940, provides for the...

Impact of Early Sport Specialization: A Physiological Perspective

ERIC Educational Resources Information Center

Kaleth, Anthony S.; Mikesky, Alan E.

2010-01-01

This article addresses the question of whether early sport specialization provides a "physiological" advantage for future athletic success. It examines the limited literature related to the effects of early specialization on the body's organ systems: the endocrine system, the muscular system, the nervous system, and the cardiovascular system. The…

44 CFR 7.925 - Special benefits for children and the elderly.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Special benefits for children and the elderly. 7.925 Section 7.925 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT... the elderly. If a recipient operating a program or activity provides special benefits to the elderly...

14 CFR 1252.203 - Special benefits for children and the elderly.

Code of Federal Regulations, 2010 CFR

2010-01-01

... elderly. 1252.203 Section 1252.203 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... Determining Age Discrimination § 1252.203 Special benefits for children and the elderly. If a recipient operating a program or activity provides special benefits to the elderly or to children, such use of age...

14 CFR 1252.203 - Special benefits for children and the elderly.

Code of Federal Regulations, 2011 CFR

2011-01-01

... elderly. 1252.203 Section 1252.203 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... Determining Age Discrimination § 1252.203 Special benefits for children and the elderly. If a recipient operating a program or activity provides special benefits to the elderly or to children, such use of age...

44 CFR 7.925 - Special benefits for children and the elderly.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Special benefits for children and the elderly. 7.925 Section 7.925 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT... the elderly. If a recipient operating a program or activity provides special benefits to the elderly...

Special Service Personnel: A Source of Help for the Teacher.

ERIC Educational Resources Information Center

Walden, S. Bernie; And Others

Examined are the roles of special service personnel (SSP) who provide support services for Iowa public school teachers by three methods: helping a specific child, helping develop instructional program content, and helping develop new instructional skills. The 13 SSPs include counselor, director of special education, educational consultant, hearing…

Overcoming Common Misunderstandings about Students with Disabilities Who Are English Language Learners

ERIC Educational Resources Information Center

Cheatham, Gregory A.; Hart Barnett, Juliet E.

2017-01-01

Special education programs are increasingly serving students with disabilities who are English language learners and their families. Facilitating bilingualism is an effective practice and aligns with culturally responsive special education service provision. It is critical for special educators and service providers to learn about bilingualism,…

38 CFR 21.3333 - Rates.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Rates. 21.3333 Section 21... Payments; Special Restorative Training § 21.3333 Rates. (a) Rates. Special training allowance is payable at the following monthly rates, except as provided in paragraph (c) of this section. (1) For special...

38 CFR 21.3333 - Rates.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Rates. 21.3333 Section 21... Payments; Special Restorative Training § 21.3333 Rates. (a) Rates. Special training allowance is payable at the following monthly rates, except as provided in paragraph (c) of this section. (1) For special...

38 CFR 21.3333 - Rates.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Rates. 21.3333 Section 21... Payments; Special Restorative Training § 21.3333 Rates. (a) Rates. Special training allowance is payable at the following monthly rates, except as provided in paragraph (c) of this section. (1) For special...

Special Education Voucher Programs, Reflective Judgment, and Future Legislative Recommendations

ERIC Educational Resources Information Center

Bon, Susan C.; Decker, Janet R.; Strassfeld, Natasha

2016-01-01

As of 2015, 17 special education voucher programs (SVPs) existed in 13 states and proposals continue to emerge. Eligible parents utilize these vouchers to enroll their children in private schools and thereby relinquish special education services and protections provided under the Individuals with Disabilities Education Act (IDEA). Using a…

38 CFR 21.3333 - Rates.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Rates. 21.3333 Section 21... Payments; Special Restorative Training § 21.3333 Rates. (a) Rates. Special training allowance is payable at the following monthly rates, except as provided in paragraph (c) of this section. (1) For special...

PREFACE SPECIAL ISSUE ON MODEL EVALUATION: EVALUATION OF URBAN AND REGIONAL EULERIAN AIR QUALITY MODELS

EPA Science Inventory

The "Preface to the Special Edition on Model Evaluation: Evaluation of Urban and Regional Eulerian Air Quality Models" is a brief introduction to the papers included in a special issue of Atmospheric Environment. The Preface provides a background for the papers, which have thei...

Tools for Teaming: Resources for Linking Vocational Programs with Special Populations.

ERIC Educational Resources Information Center

Tavares, Barbara, Ed.

This publication provides resources for linking vocational programs with five special populations. Sections 1-5 each focus on one special population and contain some or all of these resources: activities; recruitment; teacher tips; laws; staff development; funding streams; parent advice; instructional modifications; websites; community resources;…

Model Special Education Manpower Information and Management System. Final Report.

ERIC Educational Resources Information Center

Gilles, Cynthia

The Massachusetts Special Education Manpower Planning Project is described. Relying on cooperative planning, the project developed a system to provide information on manpower planning, a system to link other agencies with the project, and annual statements of state special education training priorities. The project also collaborated with six other…

An Analysis of Teacher Sorting in Secondary Special Education and Alternative Schools

ERIC Educational Resources Information Center

Mason-Williams, Loretta; Gagnon, Joseph Calvin

2017-01-01

This study provides nationally representative information about the qualifications and preparation of secondary content and special education teachers in special education and alternative school settings, as compared with teachers in regular schools. Findings demonstrate that a statistically significant relationship did not exist between school…

Access to Qualified Special Educators across Elementary Neighborhood and Exclusionary Schools

ERIC Educational Resources Information Center

Mason-Williams, Loretta; Bettini, Elizabeth; Gagnon, Joseph Calvin

2017-01-01

In this study, we investigate the distribution of qualified special educators across elementary neighborhood schools and exclusionary public and private special education schools. Using the 2011-2012 Schools and Staffing Survey, we provide a descriptive analysis of measurable teacher qualifications (e.g., years of experience, preparation type,…

Quality Improvement Program Plan for Special Educators (QUIPP), 1990-91. OREA Report.

ERIC Educational Resources Information Center

New York City Board of Education, Brooklyn, NY. Office of Research, Evaluation, and Assessment.

This evaluation report describes the Quality Improvement Program Plan for Special Educators (QUIPP) which provides supplemental professional development opportunities for New York City special education professionals and paraprofessionals at the elementary, middle, and intermediate/junior high school levels. The program stresses design of the…

Special Education Transition Predictors for Post-School Success: Findings from the Field

ERIC Educational Resources Information Center

Sprunger, Nikki S.; Harvey, Michael W.; Quick, Marilynn M.

2018-01-01

Legislation has mandated that secondary schools provide services for students with disabilities that prepare them for independent living, employment, and/or post-secondary education (IDEA, 2004). This study examined the perceptions of special education directors, assistant directors/program coordinators, and secondary special education teachers…

48 CFR 831.7001-2 - Special services or courses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... courses. 831.7001-2 Section 831.7001-2 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... and Procedures 831.7001-2 Special services or courses. Special services or courses are those services or courses that VA requests that are over and above those the institution customarily provides for...

48 CFR 831.7001-2 - Special services or courses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... courses. 831.7001-2 Section 831.7001-2 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... and Procedures 831.7001-2 Special services or courses. Special services or courses are those services or courses that VA requests that are over and above those the institution customarily provides for...

48 CFR 831.7001-2 - Special services or courses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... courses. 831.7001-2 Section 831.7001-2 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... and Procedures 831.7001-2 Special services or courses. Special services or courses are those services or courses that VA requests that are over and above those the institution customarily provides for...

48 CFR 831.7001-2 - Special services or courses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... courses. 831.7001-2 Section 831.7001-2 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... and Procedures 831.7001-2 Special services or courses. Special services or courses are those services or courses that VA requests that are over and above those the institution customarily provides for...

48 CFR 831.7001-2 - Special services or courses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... courses. 831.7001-2 Section 831.7001-2 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... and Procedures 831.7001-2 Special services or courses. Special services or courses are those services or courses that VA requests that are over and above those the institution customarily provides for...

Job Design: An Administrator's Guide to Supporting and Retaining Special Educators

ERIC Educational Resources Information Center

Bettini, Elizabeth A.; Cheyney, Kristi; Wang, Jun; Leko, Christopher

2015-01-01

Special education teacher attrition has numerous negative impacts for students and schools. Administrators play an essential role in supporting special educators, but they seldom receive adequate preparation to provide this support effectively. The authors synthesize job characteristics theory, an area of research conducted by organizational…

Special Education Teachers' Supervision of Paraeducators: A Quantitative Study of Team Sharedness

ERIC Educational Resources Information Center

Panitz, Beth L.

2012-01-01

Paraeducators, also known as paraprofessionals or teaching assistants, provide special education services for students with disabilities under the supervision of special education teachers. Despite legal requirements that paraeducators work under the direct supervision of teachers, teacher education programs lack research-based evidence to design…

The European Clinical Specialization on Fluency Disorders (ECSF)

ERIC Educational Resources Information Center

Eggers, Kurt; Leahy, Margaret

2011-01-01

The European Clinical Specialization on Fluency Disorders (ECSF) project consists of one-year post-qualification fluency specialization training and a harmonized graduate fluency program. It was developed by eight European universities/colleges to provide the means whereby graduates would meet comparable standards of competence to practice in the…

Web Resources for Special Education

ERIC Educational Resources Information Center

Singh, Delar K.

2010-01-01

The purpose of this paper is to provide brief descriptions and links to a number of reputed websites on various topics and issues of special education. The web sites are organized in the following categories: (1) Teaching in Inclusive Classroom, (2) Policies, Procedures, & Process of Special education, (3) Students with High Incidence…

36 CFR § 1002.50 - Special events.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Special events. § 1002.50... RECREATION § 1002.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however, There is a meaningful association...

Teachers' Perceptions of Greek Special Education Policies and Practices

ERIC Educational Resources Information Center

Miller, Kevin J.; Morfidi, Eleni; Soulis, Spyros

2013-01-01

Special education teachers and related service providers were interviewed for their perspectives on Greek special education policies and practices and how these influenced their job preparation and duties. Specifically, they were asked about the impact of the following on their jobs: Greek law related to the education of students with…

78 FR 36698 - Microbiology Devices; Reclassification of Nucleic Acid-Based Systems for Mycobacterium tuberculosis

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... specimens from class III (premarket approval) into class II (special controls). FDA is also issuing the draft special controls guideline entitled ``Class II Special Controls Guideline: Nucleic Acid-Based In... regulatory controls needed to provide reasonable assurance of their safety and effectiveness. The three...

Assessing LEP Migrant Students for Special Education Services. ERIC Digest.

ERIC Educational Resources Information Center

Lozano-Rodriguez, Jose R.; Castellano, Jaime A.

Many migrant students are not identified for needed special education services in a timely manner. This digest describes the obligations of schools to provide such services, and discusses approaches for student referral, assessment, and placement and working with migrant families. Federal mandates concerning special education are summarized, and…

A Practical Guide to Early Numeracy Instruction for General and Special Educators

ERIC Educational Resources Information Center

Anderson, Alida

2013-01-01

This report summarizes recommendations from NCTM, NRC, CCSSM, NMAP, and IES to guide early numeracy instruction for elementary age students in general and special education classroom settings. We highlight common threads among general and special education research recommendations and provide a numeracy intervention curriculum model connecting…

The Program Evaluation Guide: A Preliminary Review of Special Education Instruction

ERIC Educational Resources Information Center

Nulty, Elizabeth C.

2017-01-01

Special education programs vary in the quality of services provided across states, cities, and school districts. There are three major components necessary for a quality special education program for children with complex learning needs. These components include systems level analysis, capacity building for staff, and strong individual student…

Special Educators and Mathematics Phobia: An Initial Qualitative Investigation

ERIC Educational Resources Information Center

Humphrey, Michael; Hourcade, Jack J.

2010-01-01

Special educators are uniquely challenged to be content experts in all curricular areas, including mathematics, because students in their caseloads may require academic instruction in any area. However, special educators with math phobia may be limited in their ability to provide effective instruction to their students with mathematical deficits…

"It Makes History Alive for Them": The Role of Archivists and Special Collections Librarians in Instructing Undergraduates

ERIC Educational Resources Information Center

Krause, Magia G.

2010-01-01

This study explores the educational role of archivists and special collections librarians in providing instructional services aimed at undergraduate students. Twelve leading thinkers in teaching with primary sources are interviewed to provide insight on pedagogical strategies for undergraduates, assessment of instruction, and how archivists…

Introduction to the Special Issue: Children in Foster Care and International Adoption

ERIC Educational Resources Information Center

Jankowska, Anna M.

2015-01-01

Children in the foster care system and those experiencing international adoption face a host of risk factors that result in academic, behavioral, and emotional challenges. The purpose of this special issue is to provide school psychologists with the knowledge regarding current intervention strategies and programming to provide effective supports…

Research Designs and Special Education Research: Different Designs Address Different Questions

ERIC Educational Resources Information Center

Cook, Bryan G.; Cook, Lysandra

2016-01-01

The aim of this article is to provide practitioners and other nonresearchers a basic understanding of research designs to aid in appropriately interpreting and applying research findings in special education. Research design provides the blueprint for conducting a research study and shapes what kind of knowledge is generated by the study. We…

Project S.P.I.C.E.: Special Partnership in Career Education. Guide to Program Implementation.

ERIC Educational Resources Information Center

Emerson, Debby H.; And Others

The implementation guide to Project SPICE (Special Partnership in Career Education) - a curriculum designed to develop and demonstrate effective methods and techniques for providing career education experiences for educable mentally handicapped (EMH) students (ages 11-to-13 years) is provided. A description of the program focuses on program…

Psychosocial Issues for Children and Adolescents in Disasters. Second Edition.

ERIC Educational Resources Information Center

Speier, Anthony H.

Major natural and human-caused disasters deeply affect children, and they have a special vulnerability to such events. The importance of providing crisis counseling recovery assistance within the context of their special world cannot be over emphasized. The information in this manual provides both theory and guidance to individuals concerned with…

20 CFR 663.430 - Under what circumstances may mechanisms other than ITA's be used to provide training services?

Code of Federal Regulations, 2013 CFR

2013-04-01

... that there are an insufficient number of eligible providers in the local area to accomplish the purpose... private organization to serve special participant populations that face multiple barriers to employment... determining demonstrated effectiveness, particularly as it applies to the special participant population to be...

20 CFR 663.430 - Under what circumstances may mechanisms other than ITA's be used to provide training services?

Code of Federal Regulations, 2014 CFR

2014-04-01

... that there are an insufficient number of eligible providers in the local area to accomplish the purpose... private organization to serve special participant populations that face multiple barriers to employment... determining demonstrated effectiveness, particularly as it applies to the special participant population to be...

20 CFR 663.430 - Under what circumstances may mechanisms other than ITA's be used to provide training services?

Code of Federal Regulations, 2012 CFR

2012-04-01

... that there are an insufficient number of eligible providers in the local area to accomplish the purpose... private organization to serve special participant populations that face multiple barriers to employment... determining demonstrated effectiveness, particularly as it applies to the special participant population to be...

Interweaving Teaching and Emotional Support for Novice Special Educators in Alternative Certification Programs

ERIC Educational Resources Information Center

Ricci, Leila Ansari; Zetlin, Andrea G.

2013-01-01

As the shortage of special education teachers has led to increasing numbers of teacher candidates enrolled in alternative certification programs, there is a need to provide systematic mentoring and coaching. The relationship between support providers and novice teachers enrolled in an alternative certification program in a diverse, urban…

NO CHILD IS INEDUCABLE, SPECIAL EDUCATION--PROVISION AND TRENDS.

ERIC Educational Resources Information Center

SEGAL, S.S.

THE BOOK OUTLINES THE HISTORICAL DEVELOPMENT OF SPECIAL EDUCATION IN ENGLAND, PROVIDES A GUIDE TO A VARIETY OF RESOURCES, AND CONCLUDES WITH THE AUTHOR'S INFERENCES ABOUT TRENDS. PART ONE, TITLED THEORY AND PROVISION, DESCRIBES EDUCATIONAL LEGISLATION AND THE RANGE OF PROVISIONS FOR ALL TYPES OF HANDICAPPED CHILDREN, PROVIDES A BRIEF HISTORY OF…

School-Based Training and Information for Paraprofessionals: A Handbook for Practicing Paraprofessionals

ERIC Educational Resources Information Center

Santana, Jesse

2016-01-01

School enrollment is expected to increase over the next decade, and with this increase, schools in the United States have seen an increase in the number of paraprofessionals employed to provide services for special education students. Paraprofessionals are key to providing services and assistance to students with special needs toward their…

BOCES: A Delivery System for Special Education. Special Education: Innovative Programs

ERIC Educational Resources Information Center

Colella, Henry V.; Foster, Herbert

1974-01-01

New York State's Boards of Cooperative Educational Services (BOCES) now serve approximately 30,000 handicapped children, whose disabilities range from mild to severe. BOCES provide shared services to two or more member school districts that initiate the request when one or the other is unable to provide such services economically or efficiently…

Neuroscience and Special Education. inForum

ERIC Educational Resources Information Center

Muller, Eve

2011-01-01

The purpose of this document is to provide a brief overview of how links are being developed between the rapidly expanding field of neuroscience and the practice of special education. The first part of the document introduces definitions and terminology, provides an overview of how findings from neuroscience are being applied to the field of…

Adapting and Modifying Toys for Children with Special Needs.

ERIC Educational Resources Information Center

Simpson, Cynthia G.; Lynch, Sharon A.

Many caregivers doubt their ability to provide appropriate play experiences for children with special needs included in their program because some children with disabilities may not have the ability to interact and manipulate toys in a meaningful way. This paper provides guidance in appropriately adapting toys and the play situation to allow many…

Global Rural Autism Asperger Information Network: A Distance Learning Inservice Training Program.

ERIC Educational Resources Information Center

Bock, Marjorie A.; Swinney, Lori; Smart, Kathy

The University of North Dakota's Global Rural Autism Asperger Information Network (GRAAIN) provides a special graduate certificate program in Autistic Spectrum Disorder (ASD) consisting of six online courses. The program started over 4 years ago as a pilot program to provide specialized ASD training to educators and personnel serving children with…

EPA’s Role in Emergency Response - Special Teams

EPA Pesticide Factsheets

The Environmental Response Team; Radiological Response Team; Chemical, Biological, Radiological, and Nuclear Consequence Management Advisory Division; and National Criminal Enforcement Response Team provide specialized support.

Insights into the Prunus-Specific S-RNase-Based Self-Incompatibility System from a Genome-Wide Analysis of the Evolutionary Radiation of S Locus-Related F-box Genes.

PubMed

Akagi, Takashi; Henry, Isabelle M; Morimoto, Takuya; Tao, Ryutaro

2016-06-01

Self-incompatibility (SI) is an important plant reproduction mechanism that facilitates the maintenance of genetic diversity within species. Three plant families, the Solanaceae, Rosaceae and Plantaginaceae, share an S-RNase-based gametophytic SI (GSI) system that involves a single S-RNase as the pistil S determinant and several F-box genes as pollen S determinants that act via non-self-recognition. Previous evidence has suggested a specific self-recognition mechanism in Prunus (Rosaceae), raising questions about the generality of the S-RNase-based GSI system. We investigated the evolution of the pollen S determinant by comparing the sequences of the Prunus S haplotype-specific F-box gene (SFB) with those of its orthologs in other angiosperm genomes. Our results indicate that the Prunus SFB does not cluster with the pollen S of other plants and diverged early after the establishment of the Eudicots. Our results further indicate multiple F-box gene duplication events, specifically in the Rosaceae family, and suggest that the Prunus SFB gene originated in a recent Prunus-specific gene duplication event. Transcriptomic and evolutionary analyses of the Prunus S paralogs are consistent with the establishment of a Prunus-specific SI system, and the possibility of subfunctionalization differentiating the newly generated SFB from the original pollen S determinant. © The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

The Physcomitrella patens exocyst subunit EXO70.3d has distinct roles in growth and development, and is essential for completion of the moss life cycle.

PubMed

Rawat, Anamika; Brejšková, Lucie; Hála, Michal; Cvrčková, Fatima; Žárský, Viktor

2017-10-01

The exocyst, an evolutionarily conserved secretory vesicle-tethering complex, spatially controls exocytosis and membrane turnover in fungi, metazoans and plants. The exocyst subunit EXO70 exists in multiple paralogs in land plants, forming three conserved clades with assumed distinct roles. Here we report functional analysis of the first moss exocyst subunit to be studied, Physcomitrella patens PpEXO70.3d (Pp1s97_91V6), from the, as yet, poorly characterized EXO70.3 clade. Following phylogenetic analysis to confirm the presence of three ancestral land plant EXO70 clades outside angiosperms, we prepared and phenotypically characterized loss-of-function Ppexo70.3d mutants and localized PpEXO70.3d in vivo using green fluorescent protein-tagged protein expression. Disruption of PpEXO70.3d caused pleiotropic cell elongation and differentiation defects in protonemata, altered response towards exogenous auxin, increased endogenous IAA concentrations, along with defects in bud and gametophore development. During mid-archegonia development, an abnormal egg cell is formed and subsequently collapses, resulting in mutant sterility. Mutants exhibited altered cell wall and cuticle deposition, as well as compromised cytokinesis, consistent with the protein localization to the cell plate. Despite some functional redundancy allowing survival of moss lacking PpEXO70.3d, this subunit has an essential role in the moss life cycle, indicating sub-functionalization within the moss EXO70 family. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Myostatin inhibits myosatellite cell proliferation and consequently activates differentiation: evidence for endocrine-regulated transcript processing.

PubMed

Garikipati, Dilip K; Rodgers, Buel D

2012-10-01

Myostatin is a potent negative regulator of muscle growth in mammals. Despite high structural conservation, functional conservation in nonmammalian species is only assumed. This is particularly true for fish due to the presence of several myostatin paralogs: two in most species and four in salmonids (MSTN-1a, -1b, -2a, and -2b). Rainbow trout are a rich source of primary myosatellite cells as hyperplastic muscle growth occurs even in adult fish. These cells were therefore used to determine myostatin's effects on proliferation whereas our earlier studies reported its effects on quiescent cells. As in mammals, recombinant myostatin suppressed proliferation with no changes in cell morphology. Expression of MSTN-1a was several fold higher than the other paralogs and was autoregulated by myostatin, which also upregulated the expression of key differentiation markers: Myf5, MyoD1, myogenin, and myosin light chain. Thus, myostatin-stimulated cellular growth inhibition activates rather than represses differentiation. IGF-1 stimulated proliferation but had minimal and delayed effects on differentiation and its actions were suppressed by myostatin. However, IGF-1 upregulated MSTN-2a expression and the processing of its transcript, which is normally unprocessed. Myostatin therefore appears to partly mediate IGF-stimulated myosatellite differentiation in rainbow trout. This also occurs in mammals, although the IGF-stimulated processing of MSTN-2a transcripts is highly unique and is indicative of subfunctionalization within the gene family. These studies also suggest that the myokine's actions, including its antagonistic relationship with IGF-1, are conserved and that the salmonid gene family is functionally diverging.

Restriction and Recruitment—Gene Duplication and the Origin and Evolution of Snake Venom Toxins

PubMed Central

Hargreaves, Adam D.; Swain, Martin T.; Hegarty, Matthew J.; Logan, Darren W.; Mulley, John F.

2014-01-01

Snake venom has been hypothesized to have originated and diversified through a process that involves duplication of genes encoding body proteins with subsequent recruitment of the copy to the venom gland, where natural selection acts to develop or increase toxicity. However, gene duplication is known to be a rare event in vertebrate genomes, and the recruitment of duplicated genes to a novel expression domain (neofunctionalization) is an even rarer process that requires the evolution of novel combinations of transcription factor binding sites in upstream regulatory regions. Therefore, although this hypothesis concerning the evolution of snake venom is very unlikely and should be regarded with caution, it is nonetheless often assumed to be established fact, hindering research into the true origins of snake venom toxins. To critically evaluate this hypothesis, we have generated transcriptomic data for body tissues and salivary and venom glands from five species of venomous and nonvenomous reptiles. Our comparative transcriptomic analysis of these data reveals that snake venom does not evolve through the hypothesized process of duplication and recruitment of genes encoding body proteins. Indeed, our results show that many proposed venom toxins are in fact expressed in a wide variety of body tissues, including the salivary gland of nonvenomous reptiles and that these genes have therefore been restricted to the venom gland following duplication, not recruited. Thus, snake venom evolves through the duplication and subfunctionalization of genes encoding existing salivary proteins. These results highlight the danger of the elegant and intuitive “just-so story” in evolutionary biology. PMID:25079342

Supplemental Fingerprint Card Data (SFCD) for NIST Special Database 9

National Institute of Standards and Technology Data Gateway

Supplemental Fingerprint Card Data (SFCD) for NIST Special Database 9 (Web, free access)   NIST Special Database 10 (Supplemental Fingerprint Card Data for Special Database 9 - 8-Bit Gray Scale Images) provides a larger sample of fingerprint patterns that have a low natural frequency of occurrence and transitional fingerprint classes in NIST Special Database 9. The software is the same code used with NIST Special Database 4 and 9. A newer version of the compression/decompression software on the CDROM can be found at the website http://www.nist.gov/itl/iad/ig/nigos.cfm as part of the NBIS package.

A Selected Special Education Bibliography and Resource Guide.

ERIC Educational Resources Information Center

Draper, Ingrid L., Comp.

Presented is a bibliography and resource guide to assist Head Start personnel who are not experienced in special education to locate helpful resources and to provide listings of current literature and training materials for special educators. Listed in Chapter (1) are several national, state, and local sources of information and resources in each…

Technology and Interactive Multimedia. Identifying Emerging Issues and Trends in Technology for Special Education.

ERIC Educational Resources Information Center

Ashton, Ray

As part of a 3-year study to identify emerging issues and trends in technology for special education, this paper addresses the role of interactive multimedia, especially the digital, optical compact disc technologies, in providing instructional services to special education students. An overview identifies technological and economic trends,…

Policy Challenges and Opportunities for Rural Special Education

ERIC Educational Resources Information Center

Rude, Harvey; Miller, Kevin J.

2018-01-01

This article reviews current developments in state and national policies that affect rural special education. A brief overview of the federal role in rural education is provided, with emphasis on the implications for the provision of special education services in rural communities. A variety of challenges are identified, including (a) the variable…

34 CFR 607.23 - What special funding consideration does the Secretary provide?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What special funding consideration does the Secretary... Does the Secretary Make an Award? § 607.23 What special funding consideration does the Secretary... for library materials per full-time equivalent enrolled student which is less than the average...

Special Education Disabilities and Juvenile Delinquency: A Unique Challenge for School Social Work

ERIC Educational Resources Information Center

Mallett, Christopher A.; Stoddard-Dare, Patricia; Workman-Crewnshaw, Lisa

2011-01-01

In pursuit of their mission to augment the educational process, school social workers provide service to special education students and to youths at risk for juvenile delinquency. This paper builds on previous literature that has looked at the relationship between special education disabilities and youths offending behaviors and delinquency. In…

Estimating the Effectiveness of Special Education Using Large-Scale Assessment Data

ERIC Educational Resources Information Center

Ewing, Katherine Anne

2009-01-01

The inclusion of students with disabilities in large scale assessment and accountability programs has provided new opportunities to examine the impact of special education services on student achievement. Hanushek, Kain, and Rivkin (1998, 2002) evaluated the effectiveness of special education programs by examining students' gains on a large-scale…

34 CFR 110.16 - Special benefits for children and the elderly.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Special benefits for children and the elderly. 110.16 Section 110.16 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS... the elderly. If a recipient operating a program or activity provides special benefits to the elderly...

43 CFR 17.313 - Special benefits for children and the elderly.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Special benefits for children and the elderly. 17.313 Section 17.313 Public Lands: Interior Office of the Secretary of the Interior... elderly. If a recipient operating a program or activity provides special benefits to the elderly or to...

43 CFR 17.313 - Special benefits for children and the elderly.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Special benefits for children and the elderly. 17.313 Section 17.313 Public Lands: Interior Office of the Secretary of the Interior... elderly. If a recipient operating a program or activity provides special benefits to the elderly or to...

Reforms and Collaborations in Europe--China Doctoral Education

ERIC Educational Resources Information Center

Zhu, Chang; Cai, Yuzhuo; Shen, Wen-Qin; François, Karen

2017-01-01

This special issue focuses on the reforms and collaborations in Europe--China doctoral education. The articles in this special issue provide an insightful picture of the recent reforms in doctoral education in China and EU countries. Next to the structural reforms in Europe and China, the special issue papers have also specifically focused on…

Descriptive Analysis of Secondary Special Education and Transition Services Model Programs.

ERIC Educational Resources Information Center

Rusch, Frank R.; And Others

This monograph provides a descriptive analysis of five grant programs funded by the Office of Special Education and Rehabilitative Services (OSERS) in 1984. The programs were designed to stimulate the improvement and development of programs for secondary special education and to strengthen and coordinate education, training, and related services…

The West Virginia Special Education Technology Integration Specialist (SETIS) Program: 2012-2014 Evaluation Report

ERIC Educational Resources Information Center

Stohr, Amber D.

2015-01-01

The Special Education Technology Integration Specialist (SETIS) program provides professional development for special education teachers to assist them in achieving proficiency with 21st Century Technology Tools. The program completed its eighth and ninth rounds during the 2012-2013 and 2013-2014 school years, training more than 30 special…

45 CFR 1626.10 - Special eligibility questions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Special eligibility questions. 1626.10 Section 1626.10 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.10 Special eligibility questions. (a)(1) This part is not applicable to recipients providing services...

42 CFR 482.68 - Special requirements for transplant centers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 5 2013-10-01 2013-10-01 false Special requirements for transplant centers. 482.68... Specialty Hospitals § 482.68 Special requirements for transplant centers. A transplant center located within... specified in §§ 482.72 through 482.104 in order to be granted approval from CMS to provide transplant...

42 CFR 482.68 - Special requirements for transplant centers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 5 2012-10-01 2012-10-01 false Special requirements for transplant centers. 482.68... Specialty Hospitals § 482.68 Special requirements for transplant centers. A transplant center located within... specified in §§ 482.72 through 482.104 in order to be granted approval from CMS to provide transplant...

42 CFR 482.68 - Special requirements for transplant centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Special requirements for transplant centers. 482.68... Specialty Hospitals § 482.68 Special requirements for transplant centers. A transplant center located within... specified in §§ 482.72 through 482.104 in order to be granted approval from CMS to provide transplant...

42 CFR 482.68 - Special requirements for transplant centers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Special requirements for transplant centers. 482.68... Specialty Hospitals § 482.68 Special requirements for transplant centers. A transplant center located within... specified in §§ 482.72 through 482.104 in order to be granted approval from CMS to provide transplant...

42 CFR 482.68 - Special requirements for transplant centers.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 5 2014-10-01 2014-10-01 false Special requirements for transplant centers. 482.68... Specialty Hospitals § 482.68 Special requirements for transplant centers. A transplant center located within... specified in §§ 482.72 through 482.104 in order to be granted approval from CMS to provide transplant...

The State of Special Education in Catholic Schools

ERIC Educational Resources Information Center

DeFiore, Leonard

2006-01-01

Catholic educators in recent years have worked to increase their schools' capacity to provide special education services to more students. The expansion of federal programs to support students with special needs has aided in dealing with this issue, but it has also exacerbated problems. The exacerbation comes from the increased focus on both the…

Co-Teaching: An Illustration of the Complexity of Collaboration in Special Education

ERIC Educational Resources Information Center

Friend, Marilyn; Cook, Lynne; Hurley-Chamberlain, DeAnna; Shamberger, Cynthia

2010-01-01

Although collaboration among service providers has been a hallmark of special education almost since its inception, co-teaching, the sharing of instruction by a general education teacher and a special education teacher or another specialist in a general education class that includes students with disabilities, is a relatively recent application.…

Development of Competency Based Credential Programs in Southern California's High Desert Region.

ERIC Educational Resources Information Center

Burton, Louise F.; And Others

In the northern high desert region of San Bernardino County (California), about half of special education teachers do not hold special education credentials. In September 1988, the Desert-Mountain Rural Training Program began to provide appropriate training to uncredentialed special education teachers in this sparsely populated area. The program…

Off-Site Storage and Special Collections: A Study in Use and Impact in ARL Libraries in the United States

ERIC Educational Resources Information Center

Priddle, Charlotte; McCann, Laura

2015-01-01

Special collections libraries collect and preserve materials of intellectual and cultural heritage, providing access to unique research resources. As their holdings continue to expand, special collections in research libraries confront increased space pressures. Off-site storage facilities, used frequently by research libraries for general…

Republication of "A Propensity Score Matching Analysis of the Effects of Special Education Services"

ERIC Educational Resources Information Center

Morgan, Paul L.; Frisco, Michelle L.; Farkas, George; Hibel, Jacob

2017-01-01

Since the landmark enactment of Education of the Handicapped Act in 1975, special education supports and services have been provided to children with disabilities. Although costly, the intentionality of these specialized services has been to advance the educational and societal opportunities of children with disabilities as they progress to…

Problems Faced by Preservice Special Education Teachers in Jordan

ERIC Educational Resources Information Center

Al-Hiary, Ghaleb M.; Almakanin, Hisham A.; Tabbal, Suha A.

2015-01-01

One of the most important factors in the success of educating children with special needs is the quality of the special education teacher. While teachers are responsible for a plethora of duties, it is important that teacher preparation programs provide adequate training to ensure teachers are well prepared for the teaching profession. However,…

Special Education: A Reference Book for Policy & Curriculum Development. Second Edition

ERIC Educational Resources Information Center

Grey House Publishing, 2009

2009-01-01

A reference work that presents a chronology focusing on special education, its development, and the important issues that both positively and negatively affect the field. Updated through current events, this second edition provides an excellent introduction to special education in all of its practical aspects--how it developed, its curriculum,…

Teaching Students with Learning Disabilities. Programming for Students with Special Needs, Book 6.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton. Special Education Branch.

Part of a seven-book series called "Programming for Students with Special Needs," this book offers all teachers information to enhance their understanding of learning disabilities and provides practical strategies to assist in teaching students with special needs. Section 1 discusses the definition of learning disabilities, labeling, and…

Using Virtual Technology to Enhance Field Experiences for Pre-Service Special Education Teachers

ERIC Educational Resources Information Center

Billingsley, Glenna M.; Scheuermann, Brenda K.

2014-01-01

Teacher educators of pre-service teachers of students with special needs face challenges in providing the unique knowledge and skills required of highly qualified special education teachers. The emerging use of various forms of virtual technology, however, offers realistic solutions to these problems. This systematic review of literature examines…

Meeting Students' Special Needs in Catholic Schools: A Report from the USA

ERIC Educational Resources Information Center

Scanlan, Martin

2017-01-01

Students experience a wide array of special needs, from diagnosed disabilities to cultural and linguistic barriers to traumas. Schools around the world and across public and private sectors struggle to provide optimal opportunities to learn for students experiencing special needs. Moreover, schools typically engage in these efforts in isolation…

Smoking Cessation: Next Steps for Special Populations Research and Innovative Treatments

ERIC Educational Resources Information Center

Borrelli, Belinda

2010-01-01

Objective: The current introductory article provides the rationale for the special section on understudied smokers and innovative treatments. This article proposes a definition of "special populations" of smokers, outlines a priori criteria by which to judge whether an intervention should be adapted for these smokers, and delineates a process by…

Beginning Special Education Teachers of Students with Emotional/Behavioral Disorders

ERIC Educational Resources Information Center

Pressley, Denise Marie

2013-01-01

In an attempt to provide educational services to students eligible to receive special education, school systems are using beginning out-of-field teachers. The purpose of this phenomenological study was to determine which skills, knowledge, training methods, and support beginning out-of-field special education teachers identified as necessary to…

Differentiating Science Instruction and Assessment for Learners with Special Needs, K-8

ERIC Educational Resources Information Center

Finson, Kevin D.; Ormsbee, Christine K.; Jensen, Mary M.

2011-01-01

Teachers are required to provide appropriate science instruction to all students, including children with special needs. However, educators are often left on their own to figure out how to effectively differentiate lessons and activities. This timely, practical guidebook shows general and special educators how to retool science activities and…

75 FR 39 - Special Conditions: Boeing Model 757 Series Airplanes; Seats With Non-Traditional, Large, Non...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

...-traditional, large, non-metallic panels in their designs. To provide a level of safety that is equivalent to...; Special Conditions No. 25-397-SC] Special Conditions: Boeing Model 757 Series Airplanes; Seats With Non-Traditional, Large, Non-Metallic Panels AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final...

New Orleans Cuisine: "Hamlet" to Bubble Gum.

ERIC Educational Resources Information Center

Monroe, Betty J.

Paperback publications are an ideal way to supplement the adopted textbook series of the New Orleans Public Schools or to provide common reading materials for special courses or for special students in special schools. Though established guidelines are helpful in making decisions about what books should be read by students, there is no system-wide…

Rules for the Provision of Special Education to Special Education Students. Chapter 392-172 WAC.

ERIC Educational Resources Information Center

Washington Office of the State Superintendent of Public Instruction, Olympia.

This handbook provides state legal regulations for Washington State special education services and programs for students with disabilities. It includes requirements that address the following areas: (1) general authority and purpose of the requirements; (2) students' rights; (3) general definitions; (4) child find; (5) evaluation procedures; (6)…

Commonsense Methods for Children with Special Educational Needs: Strategies for the Regular Classroom. Fourth Edition.

ERIC Educational Resources Information Center

Westwood, Peter

This book is designed to provide teachers with an immediate and comprehensive source of practical strategies for meeting children's special needs in regular classrooms. Chapter 1 explores issues relating to children with general and specific learning difficulties. It discusses inclusive schooling and special educational needs, factors associated…

Special Education Services: A Manual of Policies, Procedures and Guidelines

ERIC Educational Resources Information Center

British Columbia Ministry of Education, 2013

2013-01-01

This resource conveys policies, procedures, and guidelines that support the delivery of special education services in British Columbia's (Canada) public schools. It was originally published in 1995 (ED414703), following an extensive provincial Special Education Review (1993-94). The purpose of this manual is to provide a single point of reference…

Engaging Students Regarding Special Needs in Technology and Engineering Education

ERIC Educational Resources Information Center

White, David W.

2015-01-01

In 1984, James Buffer and Michael Scott produced the book "Special Needs Guide for Technology Education" (Buffer and Scott, 1984). This was a pivotal offering insofar as it set the stage for technology education educators, at the time, to think about and be provided with information regarding students with special needs in their…

14 CFR 382.31 - May carriers impose special charges on passengers with a disability for providing services and...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false May carriers impose special charges on... 382.31 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Nondiscrimination...

14 CFR 382.31 - May carriers impose special charges on passengers with a disability for providing services and...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false May carriers impose special charges on... 382.31 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Nondiscrimination...

Enhancing Pre-Service Special Educator Preparation through Combined Use of Virtual Simulation and Instructional Coaching

ERIC Educational Resources Information Center

Peterson-Ahmad, Maria

2018-01-01

To meet the ever-increasing teaching standards, pre-service special educators need extensive and advanced opportunities for pedagogical preparation prior to entering the classroom. Providing opportunities for pre-service special educators to practice such strategies within a virtual simulation environment offers teacher preparation programs a way…

Special Education and Severe Disabilities in Costa Rica: Developing Inclusion in a Developing Country.

ERIC Educational Resources Information Center

Stough, Laura M.

2003-01-01

An overview of special education in Costa Rica is provided. Costa Rica has promulgated four educational service models that extend special education expertise: consulting teachers, educational assistance teams, itinerant teams, and resource centers. Their educational classification system describes the level of modifications required by students.…

Retention in Special Education Teachers in Georgia: A Phenomenological Approach

ERIC Educational Resources Information Center

Jackson, Arndra N.

2012-01-01

The purpose of this qualitative study using a phenomenological approach was to identify and examine factors influencing the retention rate of special education teachers in rural and urban schools in middle Georgia. Provided in this study are factors that are related to retention in special education teachers. Semistructured interviews were used to…

A Vocational/Special Education Individualized Transitional Planner (School to Work).

ERIC Educational Resources Information Center

Youshock, Joseph M.; Gilgannon, Nancy

This individualized transition plan manual can be used by special and vocational educators in developing a curriculum plan for handicapped or special needs learners based on career goals and job selection. The introductory sections provide a description of the individual transition planning model, an outline of communication skills, and a list of…

14 CFR 382.31 - May carriers impose special charges on passengers with a disability for providing services and...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false May carriers impose special charges on... 382.31 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Nondiscrimination...

14 CFR 382.31 - May carriers impose special charges on passengers with a disability for providing services and...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false May carriers impose special charges on... 382.31 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Nondiscrimination...

14 CFR 382.31 - May carriers impose special charges on passengers with a disability for providing services and...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false May carriers impose special charges on... 382.31 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Nondiscrimination...

Targeting Resources to Students with Special Educational Needs: National Differences in Policy and Practice

ERIC Educational Resources Information Center

Deluca, Marcella; Stillings, Cara

2008-01-01

Multiple policy strategies exist to promote equity and inclusion in education and training systems. Across countries, the provision of additional resources to students with special educational needs is a common strategy; previous research indicates that providing extra resources to students with special educational needs can help those students…

2017 State Policy Review: School and District Leadership. Special Report

ERIC Educational Resources Information Center

Scott, Deven

2017-01-01

This special report provides context and examples of new legislation impacting preparation, certification, induction, professional development, evaluation and compensation for leaders of schools and districts.

The Education Act (Ontario) 1980: A Review.

ERIC Educational Resources Information Center

Hodder, C. J.

1984-01-01

Ontario has provided special education legislation through the Education Amendment Act, 1980. Issues related to teacher preparation for special education and program planning and implementation are reviewed. (DF)

An Evaluation of Past Special Education Programs and Services Provided to Incarcerated Young Offenders

ERIC Educational Resources Information Center

Ingalls, Lawrence; Hammond, Helen; Trussell, Robert P.

2011-01-01

This study investigated the past special education programs and services provided to children and youth who later became incarcerated. Participants in this study were inmates from a medium security state correctional facility in the southwest region of the United States. All inmates involved in this study were identified as having a disability and…

The Impact of IDEA 04 and NCLB on Speech and Language Related Services: How Do We Meet the Challenges

ERIC Educational Resources Information Center

Means, Jennifer

2006-01-01

As most special educators endure the periodic legal changes in education and special education, related service providers face the same challenges. These challenges include Inclusion, IDEA 04 regulations, NCLB and curricular related services. This paper presents these challenges and discusses a variety of solutions providing the most appropriate…

Minimum Objectives: A Measurement System to Provide Evaluation of Special Education in Regular Classrooms.

ERIC Educational Resources Information Center

Christie, Lu S.; McKenzie, Hugh S.

Discussed is the use of minimum behavioral objectives to provide evaluation of special education in regular classrooms. Literature which supports the mainstreaming of moderately handicapped children is reviewed briefly. Application of the behavioral model of education on the community level is considered in terms of the basic skills which comprise…

Why Not Competence? A Guide for Training Special Education Aides.

ERIC Educational Resources Information Center

Semrau, Barbara L.; And Others

The manual is designed for use by trainers of special education teacher aides to provide a competency based course which will enable teacher aides to assist in the implementation of the requirements of P.L. 94-142 (the Education for All Handicapped Children Act). The first section provides background information to give trainers the grasp of…

20 CFR 663.430 - Under what circumstances may mechanisms other than ITA's be used to provide training services?

Code of Federal Regulations, 2011 CFR

2011-04-01

... are an insufficient number of eligible providers in the local area to accomplish the purpose of a... organization to serve special participant populations that face multiple barriers to employment, as described... demonstrated effectiveness, particularly as it applies to the special participant population to be served. The...

34 CFR 380.20 - What requirements must a grantee meet before it provides for the transition of an individual in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL PROJECTS AND DEMONSTRATIONS FOR PROVIDING SUPPORTED... 34 Education 2 2010-07-01 2010-07-01 false What requirements must a grantee meet before it...

34 CFR 675.41 - Special definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... institutionally organized or approved study abroad or externship program; and (4) Provides students participating..., DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Work-Colleges Program § 675.41 Special definitions. The...

34 CFR 675.41 - Special definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... institutionally organized or approved study abroad or externship program; and (4) Provides students participating..., DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Work-Colleges Program § 675.41 Special definitions. The...

34 CFR 675.41 - Special definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... institutionally organized or approved study abroad or externship program; and (4) Provides students participating..., DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Work-Colleges Program § 675.41 Special definitions. The...

34 CFR 675.41 - Special definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... institutionally organized or approved study abroad or externship program; and (4) Provides students participating..., DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Work-Colleges Program § 675.41 Special definitions. The...

Probing the Limits: Collected Works on the Second Law of Thermodynamics and Special Relativity

NASA Astrophysics Data System (ADS)

D'Abramo, Germano

2017-01-01

Synopsis: This book brings together the chief results of the research work carried out by the author on the second law of thermodynamics and the theory of special relativity since 2008. The first six chapters are devoted to the research on the epistemological status of the second law of thermodynamics and the connection between thermionic/photoelectric phenomena and the second law: evidence is provided that thermionic emission could, in principle, violate the second law. More precisely, the photoelectric emission induced by the high-frequency tail of black-body radiation at room temperature (heat) can be harnessed to charge a capacitor and provide readily usable energy from a single heat reservoir. Chapter 7 contains some reflections on special relativity. It is the most speculative part of the book and it has not been published elsewhere. Two thought experiments on time dilation in the framework of special relativity are presented. The main contention in this part of the book is that if both postulates of special relativity are assumed to hold concurrently, then the prediction of asymmetric ageing made by Einstein in his 1905 relativity paper appears to be in fact incompatible with them and the fact that time dilation (which is intimately related to "asymmetric ageing") seems to have been experimentally confirmed provides, paradoxically, a refutation rather than a confirmation of the theory of special relativity, at least as interpreted today. A critical assessment of Purcell's basic explanation of magnetic forces, which basically relies on special relativity, is also given at the end of the book.

The role of the independent neuropsychologist in special education.

PubMed

Hurewitz, Felicia; Kerr, Sonja

2011-08-01

Neuropsychologists are playing an increasing role in special education. We explain steps that neuropsychologists can take to ethically and effectively approach the "quasi-forensic" role of independent evaluator. Because neuropsychologists may provide reports for treatment, school programming, and legal disputes, it is important that they are familiar with the school programming process and the unique litigation procedures available for children with disabilities in special education. We provide guidelines including determining referral questions, obtaining outside information, choosing assessments, considering the legal constructs of questions, reviewing discrepant results from other evaluations and Individual Education Plans and communicating ideas.

The Military Assistance Command-Vietnam Studies and Observations Group-A Case Study in Special Operations Campaigning

DTIC Science & Technology

2016-06-10

viewed as the panacea for all military problems. Politicians view SOF as a low risk minimalist investment that produces results; even for problems...of published work that has been dedicated to discussing special operations theory as an element of military strategy. A good starting point to...utility. Doctrine As a starting point for framing understanding of special operations, Joint Publication (JP) 3-05 Special Operations, provides the basis

Evolution of developmental roles of Pax2/5/8 paralogs after independent duplication in urochordate and vertebrate lineages

PubMed Central

Bassham, Susan; Cañestro, Cristian; Postlethwait, John H

2008-01-01

Background Gene duplication provides opportunities for lineage diversification and evolution of developmental novelties. Duplicated genes generally either disappear by accumulation of mutations (nonfunctionalization), or are preserved either by the origin of positively selected functions in one or both duplicates (neofunctionalization), or by the partitioning of original gene subfunctions between the duplicates (subfunctionalization). The Pax2/5/8 family of important developmental regulators has undergone parallel expansion among chordate groups. After the divergence of urochordate and vertebrate lineages, two rounds of independent gene duplications resulted in the Pax2, Pax5, and Pax8 genes of most vertebrates (the sister group of the urochordates), and an additional duplication provided the pax2a and pax2b duplicates in teleost fish. Separate from the vertebrate genome expansions, a duplication also created two Pax2/5/8 genes in the common ancestor of ascidian and larvacean urochordates. Results To better understand mechanisms underlying the evolution of duplicated genes, we investigated, in the larvacean urochordate Oikopleura dioica, the embryonic gene expression patterns of Pax2/5/8 paralogs. We compared the larvacean and ascidian expression patterns to infer modular subfunctions present in the single pre-duplication Pax2/5/8 gene of stem urochordates, and we compared vertebrate and urochordate expression to infer the suite of Pax2/5/8 gene subfunctions in the common ancestor of olfactores (vertebrates + urochordates). Expression pattern differences of larvacean and ascidian Pax2/5/8 orthologs in the endostyle, pharynx and hindgut suggest that some ancestral gene functions have been partitioned differently to the duplicates in the two urochordate lineages. Novel expression in the larvacean heart may have resulted from the neofunctionalization of a Pax2/5/8 gene in the urochordates. Expression of larvacean Pax2/5/8 in the endostyle, in sites of epithelial remodeling, and in sensory tissues evokes like functions of Pax2, Pax5 and Pax8 in vertebrate embryos, and may indicate ancient origins for these functions in the chordate common ancestor. Conclusion Comparative analysis of expression patterns of chordate Pax2/5/8 duplicates, rooted on the single-copy Pax2/5/8 gene of amphioxus, whose lineage diverged basally among chordates, provides new insights into the evolution and development of the heart, thyroid, pharynx, stomodeum and placodes in chordates; supports the controversial conclusion that the atrial siphon of ascidians and the otic placode in vertebrates are homologous; and backs the notion that Pax2/5/8 functioned in ancestral chordates to engineer epithelial fusions and perforations, including gill slit openings. PMID:18721460

47 CFR 90.656 - Responsibilities of base station licensees of Specialized Mobile Radio systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Responsibilities of base station licensees of... Bands § 90.656 Responsibilities of base station licensees of Specialized Mobile Radio systems. (a) The licensees of base stations that provide Specialized Mobile Radio service on a commercial basis of the use of...

Special Education Coordinator: Learning Lessons From All Our Students

ERIC Educational Resources Information Center

Satterley, Donna

2015-01-01

As a special education coordinator of students with learning disabilities, I come into contact quite frequently with students who are considered twice exceptional. My role is to provide support to teachers on how to best meet the needs of the students with special needs in my school district. It is imperative that collaboration occurs between…

Programs for Children with Special Needs in Iran: The Importance of Early Intervention

ERIC Educational Resources Information Center

Malekpour, Mokhtar

2007-01-01

The purpose of this paper is to discuss programs that serve children with special needs in Iran, as well as early intervention. These programs are provided through two separate governmental organizations: the Well-Fare Department, and Special Education Organization. These programs include different types of habilitation services such as (a)…

A Collaborative Program To Prepare Mainstream Teachers: Using Peer Supervision by General and Special Educators.

ERIC Educational Resources Information Center

Ludlow, Barbara L.; Wienke, Wilfred D.; Henderson, Joan; Klein, Holly

As increasing numbers of students with disabilities are placed in regular classrooms, the shortage of rural special educators means that many rural classroom teachers are the primary providers of individualized programming to meet special needs. Since 1994, West Virginia University has been expanding its existing teacher education programs to…

Free Appropriate Public Education (FAPE): Special Education and Related Services. Issues in Education. Technical Assistance Bulletin.

ERIC Educational Resources Information Center

Missouri State Dept. of Elementary and Secondary Education, Jefferson City. Div. of Special Education.

This bulletin provides guidance and direction to Missouri local education agencies (LEAs) and Individualized Education Program (IEP) teams regarding the U.S. Office of Special Education Program's findings that indicated Missouri students with disabilities were not always receiving all of the special education and related services that were…

Functional Curriculum for Elementary, Middle, and Secondary Age Students with Special Needs. Second Edition

ERIC Educational Resources Information Center

Wehman, Paul; Kregel, John

2004-01-01

The second edition of Functional Curriculum for Elementary, Middle, and Secondary Age Students with Special Needs has an expanded framework for a functional and longitudinal curriculum for children and adolescents with disabilities and other special needs. These is a stronger demand than ever to provide a curriculum with everyday usefulness and…

76 FR 15214 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-21

...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... during the ``Potomac River Sharkfest Swim'' amateur swim, a marine event to be held on the waters of the Potomac River. These special local regulations are necessary to provide for the safety of life on...

41 CFR 101-8.709 - Special benefits for children and the elderly.

Code of Federal Regulations, 2011 CFR

2011-07-01

... children and the elderly. 101-8.709 Section 101-8.709 Public Contracts and Property Management Federal... § 101-8.709 Special benefits for children and the elderly. If a recipient's program or activity provides special benefits to the elderly or to children, such use of age distinctions is presumed to be necessary...

41 CFR 101-8.709 - Special benefits for children and the elderly.

Code of Federal Regulations, 2010 CFR

2010-07-01

... children and the elderly. 101-8.709 Section 101-8.709 Public Contracts and Property Management Federal... § 101-8.709 Special benefits for children and the elderly. If a recipient's program or activity provides special benefits to the elderly or to children, such use of age distinctions is presumed to be necessary...

Caring for Children with Special Needs. BNA Special Report Series on Work & Family. Special Report #43.

ERIC Educational Resources Information Center

Ott-Worrow, Karen; Baldassano, Victoria A.

This report examines day care needs and services for families with handicapped children. A section providing background information identifies barriers to finding day care for these children and discusses the relevance of federal legislation, especially the Americans with Disabilities Act of 1990. The next section presents information on standards…

42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules on supplemental benefits for MA MSA... and Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses...

42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules on supplemental benefits for MA MSA... Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses that count...

42 CFR 422.216 - Special rules for MA private fee-for-service plans.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules for MA private fee-for-service plans... With Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and...

42 CFR 422.216 - Special rules for MA private fee-for-service plans.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules for MA private fee-for-service plans... With Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and...

42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules on supplemental benefits for MA MSA... and Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses...

42 CFR 422.216 - Special rules for MA private fee-for-service plans.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules for MA private fee-for-service plans... With Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and...

42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules on supplemental benefits for MA MSA... and Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses...

42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules on supplemental benefits for MA MSA... Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses that count...

Annual Report of Indian Education in Montana. Johnson-O'Malley Activities, Fiscal Year 1974.

ERIC Educational Resources Information Center

Montana State Office of the Superintendent of Public Instruction, Helena.

Montana's Johnson-O'Malley (JOM) funds provided services for 6,094 and 7,613 Indian students respectively in 1973 and 1974. JOM funds were channeled into special projects, i.e., home-school coordinators, tutors, counselors, special transportation, special teachers, Indian teacher aides, Indian studies classes, summer programs, field trips,…

Strengthening Partnerships between Special Education Teacher Educators and Schools. Induction Insights. Supporting Special Education Teachers-Policymakers [PII-3

ERIC Educational Resources Information Center

National Center to Inform Policy and Practice in Special Education Professional Development, 2010

2010-01-01

Partnerships among institutions of higher education and school districts are desirable. Partnerships enable organizations to leverage their resources as well as expand and enhance their capabilities. They also provide opportunities for personnel with specialized areas of expertise to address shared challenges. Partnerships take considerable time,…

Preparing Effective Special Education Teachers. What Works for Special-Needs Learners Series

ERIC Educational Resources Information Center

Mamlin, Nancy

2012-01-01

What tools are in the toolkit of an excellent special educator, and how can teacher preparation programs provide these tools in the most efficient, effective way possible? This practical, clearly written book is grounded in current research and policy as well as the author's extensive experience as a teacher educator. It identifies what special…

The "special K" in kaizen.

PubMed

McAtee, L F

1999-05-01

Do you want a strategy that guarantees the success of kaizen in your organization? This article will provide insights as to why one organization may succeed and another fails. Learn why the "Special K" is the difference. Idea will be presented on how to develop the "Special K" in others and ourselves. You will be challenged to become a "kaizener".

Public and Private School Principals' Knowledge of Special Education Law

ERIC Educational Resources Information Center

Boyd, Marie Nicole

2018-01-01

The purpose of this study is to examine the knowledge of special education law held by public and private school principals as the law pertains to providing the appropriate services to students with disabilities. Numerous studies have investigated public school principals' level of preparation, training, and role within in special education law.…

Alaskan Natives and Other Minorities in the Special Education Programs of Four Alaskan School Districts.

ERIC Educational Resources Information Center

Pilla, Thomas V.

This report provides information on the percentages of Native Alaskans and other minorities in the special education programs of four Alaskan school districts. It was prompted by a civil rights complaint by parents in the Juneau School District alleging that Native Alaskans were overrepresented in special education programs. The complaint was…

Special Needs, Successful Inclusion: A Guide to Planning Community Activities for Children with Special Needs.

ERIC Educational Resources Information Center

Newman, Cynthia

This guide to including children with special needs in community programs in New Jersey begins with a history of the inclusion movement, stressing the importance of personal experiences and beliefs and ways in which inclusion benefits everyone. The following chapter provides answers to 32 frequently asked questions on successful inclusion of…

Behavioral Disorders: Practice Concerns and Students with EBD. Advances in Special Education. Volume 23

ERIC Educational Resources Information Center

Bakken, Jeffrey P., Ed.; Obiakor, Festus E., Ed.; Rotatori, Anthony F., Ed.

2012-01-01

Volumes 22 and 23 of the "Advances in Special Education" address the current top perspectives and issues in the field of emotional and behavioral disorders (EBD) by providing chapters written by active researchers and scholarly university professors who specialize in this area. Volume 22 first delineates legal issues, themes, and dimensions…

77 FR 16974 - Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-23

...-AA08 Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI AGENCY... Island, for the Ocean State Tall Ships Festival 2012. This action is necessary to provide for the safety..., during the Ocean State Tall Ships Festival on July 6-9, 2012. These temporary special local regulations...

34 CFR 380.1 - What is the program of special projects and demonstrations for providing supported employment...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false What is the program of special projects and... technical assistance projects? 380.1 Section 380.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION...

"Unconscious" Inclusion of Students with Learning Disabilities in a Malaysian Mainstream Primary School: Teachers' Perspectives

ERIC Educational Resources Information Center

Lee, Lay Wah; Low, Hui Min

2013-01-01

The inclusion of children with special needs in mainstream regular schools has been seen as the best practice in special education provision, most markedly since the 90s. International research has provided amassing evidence towards the advantages of inclusive model over a segregation model of special education provision. However, nearly two…

Identifying and Caring for Rare Books in the Community or Junior College with No Special Collections Department.

ERIC Educational Resources Information Center

Visser, Michelle

2003-01-01

Discusses issues of identifying, storing, handling, and providing access to rare books and materials in institutions without special collections departments. Suggests that although many community colleges do not collect rare materials, they may nonetheless be in possession of books that are rare and that should receive special care. (ontains four…

26 CFR 1.818-8 - Special rules relating to consolidated returns and certain capital losses.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Special rules relating to consolidated returns... Special rules relating to consolidated returns and certain capital losses. Section 818(g) provides that, in the case of a life insurance company filing or required to file a consolidated return under...

78 FR 40391 - Special Local Regulations; Dinghy Poker Run, Middle River; Baltimore County, Essex, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-05

... the rule is to ensure safety of life on navigable waters of the United States during the Dinghy Poker...: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard proposes to establish special... River. These special local regulations are necessary to provide for the safety of life on navigable...

Identification of Special Educational Needs for Early Childhood Inclusive Education in Ghana

ERIC Educational Resources Information Center

Mensah, Florence Akua; Badu-Shayar, Jeremiah

2016-01-01

Early Childhood Education is a key element for the growth and development of every country. This paper, provides a summary of reviewing the impact of early childhood special educational assessment on children to be "at risk" of developing special educational needs. It was identified mainly that early identification of at-risk factors for…

Project TOMORROW. Special Projects in Vocational Education for Youth and Adults with Special Needs.

ERIC Educational Resources Information Center

Huffman, Harry; And Others

Project TOMORROW is designed to provide better vocational education for Colorado youth and adults who have special problems, including social and economic disadvantagement, participation in student unrest, disinterest in education, dropping out of school, lack of motivation, and drug use. Phase 1 of the project (1970-1971) sought to help a number…

75 FR 32 - Special Conditions: Airbus Model A340 Series Airplanes; Seats With Non-Traditional, Large, Non...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

... incorporate non-traditional, large, non-metallic panels. To provide a level of safety that is equivalent to...; Special Conditions No. 25-399-SC] Special Conditions: Airbus Model A340 Series Airplanes; Seats With Non-Traditional, Large, Non-Metallic Panels AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final...

Elementary Analysis of the Special Relativistic Combination of Velocities, Wigner Rotation and Thomas Precession

ERIC Educational Resources Information Center

O'Donnell, Kane; Visser, Matt

2011-01-01

The purpose of this paper is to provide an elementary introduction to the qualitative and quantitative results of velocity combination in special relativity, including the Wigner rotation and Thomas precession. We utilize only the most familiar tools of special relativity, in arguments presented at three differing levels: (1) utterly elementary,…

States Seek Federal Waivers to Cut Special Education

ERIC Educational Resources Information Center

Samuels, Christina A.

2010-01-01

At least three states have asked for permission to cut back on the money they provide districts for special education, under a built-in escape clause in the federal special education law that is aimed at financially struggling states. Iowa and Kansas have both been granted a waiver, which under the Individuals with Disabilities Education Act…

School Transitions: A Qualitative Study of the Supports Provided by Washington State Special Education Administrators

ERIC Educational Resources Information Center

Lewinsohn, Kari

2013-01-01

This study investigated the role of special education administrators in the transition planning process for children with disabilities ages 3-21 in selected Washington school districts. A basic qualitative study was selected to construct meaning from a described phenomenon. The study sought to identify and explain how special education…

An Evaluation of a Decade of a Rural Field-Based Special and Elementary Teacher Training Program.

ERIC Educational Resources Information Center

Medina, Catherine; Redsteer, Denise; Prater, Greg; Minner, Sam

To address the need for special education teachers trained in rural and culturally diverse settings, a field-based special education program was implemented in Kayenta Unified School District (KUSD), Arizona, on the Navajo Nation. KUSD provided teacher housing, classroom space, sites for practicum coursework, and some student teaching placements.…

"That's Where the Rubber Meets the Road": The Intersection of Special Education and Dual Language Education

ERIC Educational Resources Information Center

Kangas, Sara E. N.

2017-01-01

Background: English language learners (ELLs) with special needs remain an underresearched student population. Although providing services to these students proves to be a daunting task, bilingual schools are uniquely poised to meet the educational needs of ELLs with special needs. Yet, research has not explored service provision practices in…

38 CFR 61.42 - Threshold requirements for special needs grant applications.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Threshold requirements for special needs grant applications. 61.42 Section 61.42 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM § 61.42 Threshold requirements for special needs grant...

42 CFR 435.236 - Individuals in institutions who are eligible under a special income level.

Code of Federal Regulations, 2010 CFR

2010-10-01

... a special income level. 435.236 Section 435.236 Public Health CENTERS FOR MEDICARE & MEDICAID... in institutions who are eligible under a special income level. (a) If the agency provides Medicaid... not institutionalized; but (2) Have income below a level specified in the plan under § 435.722. (See...

Identification and analysis of MKK and MPK gene families in canola (Brassica napus L.).

PubMed

Liang, Wanwan; Yang, Bo; Yu, Bao-Jun; Zhou, Zili; Li, Cui; Jia, Ming; Sun, Yun; Zhang, Yue; Wu, Feifei; Zhang, Hanfeng; Wang, Boya; Deyholos, Michael K; Jiang, Yuan-Qing

2013-06-11

Eukaryotic mitogen-activated protein kinase (MAPK/MPK) signaling cascades transduce and amplify environmental signals via three types of reversibly phosphorylated kinases to activate defense gene expression. Canola (oilseed rape, Brassica napus) is a major crop in temperate regions. Identification and characterization of MAPK and MAPK kinases (MAPKK/MKK) of canola will help to elucidate their role in responses to abiotic and biotic stresses. We describe the identification and analysis of seven MKK (BnaMKK) and 12 MPK (BnaMPK) members from canola. Sequence alignments and phylogenetic analyses of the predicted amino acid sequences of BnaMKKs and BnaMPKs classified them into four different groups. We also examined the subcellular localization of four and two members of BnaMKK and BnaMPK gene families, respectively, using green fluorescent protein (GFP) and, found GFP signals in both nuclei and cytoplasm. Furthermore, we identified several interesting interaction pairs through yeast two-hybrid (Y2H) analysis of interactions between BnaMKKs and BnaMPKs, as well as BnaMPK and BnaWRKYs. We defined contiguous signaling modules including BnaMKK9-BnaMPK1/2-BnaWRKY53, BnaMKK2/4/5-BnaMPK3/6-BnaWRKY20/26 and BnaMKK9-BnaMPK5/9/19/20. Of these, several interactions had not been previously described in any species. Selected interactions were validated in vivo by a bimolecular fluorescence complementation (BiFC) assay. Transcriptional responses of a subset of canola MKK and MPK genes to stimuli including fungal pathogens, hormones and abiotic stress treatments were analyzed through real-time RT-PCR and we identified a few of BnaMKKs and BnaMPKs responding to salicylic acid (SA), oxalic acid (OA), Sclerotinia sclerotiorum or other stress conditions. Comparisons of expression patterns of putative orthologs in canola and Arabidopsis showed that transcript expression patterns were generally conserved, with some differences suggestive of sub-functionalization. We identified seven MKK and 12 MPK genes from canola and examined their phylogenetic relationships, transcript expression patterns, subcellular localization, and protein-protein interactions. Not all expression patterns and interactions were conserved between canola and Arabidopsis, highlighting the limitations of drawing inferences about crops from model species. The data presented here provide the first systematic description of MKK-MPK-WRKY signaling modules in canola and will further improve our understanding of defense responses in general and provide a basis for future crop improvement.

20 CFR 655.1293 - Special procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Establishment of special procedures. To provide for a limited degree of flexibility in carrying out the... other livestock), and for custom combine crews. In a like manner, for work in occupations characterized...

The Individuals With Disabilities Education Act (IDEA) for Children With Special Educational Needs.

PubMed

Lipkin, Paul H; Okamoto, Jeffrey

2015-12-01

The pediatric health care provider has a critical role in supporting the health and well-being of children and adolescents in all settings, including early intervention (EI), preschool, and school environments. It is estimated that 15% of children in the United States have a disability. The Individuals with Disabilities Education Act entitles every affected child in the United States from infancy to young adulthood to a free appropriate public education through EI and special education services. These services bolster development and learning of children with various disabilities. This clinical report provides the pediatric health care provider with a summary of key components of the most recent version of this law. Guidance is also provided to ensure that every child in need receives the EI and special education services to which he or she is entitled. Copyright © 2015 by the American Academy of Pediatrics.

Urban special education policy and the lived experience of stigma in a high school science classroom

NASA Astrophysics Data System (ADS)

Hale, Chris

2015-12-01

In this paper, I provide a window into the lived experience of a group of urban high school science students confronted with the stigma associated with special education, disability, and academic failure and present tools to understanding the ideological forces and institutional structures that undermine the ability of schools to create a culture of care and inclusion of children with disabilities. With the purpose of understanding the context of these students' tainted social status within the school community, I draw connections between the ideological bipolarity and ambiguity of federal and state special education law and the lack of moral commitment at the local level to including and protecting the rights of children with disabilities in New York City schools. An important element of this paper is an exploration of a decade of neoliberal reform in the New York City Department of Education and the meticulously documented failure of New York City's special education system to provide mandated services, adequately include special education students, and generally protect the rights of children with disabilities. I conclude that the ableism embedded in special education law and a lack of meaningful enforcement renders special education regulations intangible to administrators whereas neoliberal performance benchmarks are extremely salient due to the dire consequences for schools of not meeting them.

Project S.P.I.C.E.: Special Partnership in Career Education. Career/Educational Awareness Teaching Module.

ERIC Educational Resources Information Center

Emerson, Debby H.; And Others

The career/educational awareness teaching module is one of a series of six modules prepared by Project SPICE (Special Partnership in Career Education) as a means of providing career awareness information to educable mentally handicapped students (ages 11-to-13 years). After an overview, a module profile is provided which charts the activities and…

Project S.P.I.C.E.: Special Partnership in Career Education. Economic Awareness Teaching Module.

ERIC Educational Resources Information Center

Emerson, Debby H.; And Others

The economic awareness teaching module is one of a series of six modules prepared by Project SPICE (Special Partnership in Career Education) as a means of providing career awareness information to educable mentally handicapped students (ages 11-to-13 years). After an overview, a module profile is provided which charts the units, the activities in…

Project S.P.I.C.E.: Special Partnership in Career Education. Self-Awareness Teaching Module.

ERIC Educational Resources Information Center

Emerson, Debby H.; And Others

The self awareness teaching module is one of a series of six modules prepared by Project SPICE (Special Partnership in Career Education) as a means of providing career awareness information to educable mentally handicapped students (ages 11-to-13 years). After an overview, a module profile is provided which charts the units, the activities in each…

Project S.P.I.C.E.: Special Partnership in Career Education. Rights and Responsibility Teaching Module.

ERIC Educational Resources Information Center

Emerson, Debby H.; And Others

The rights and responsibility teaching module is one of a series of six modules prepared by Project SPICE (Special Partnership in Career Education) as a means of providing career awareness information to educable mentally handicapped students (ages 11-to-13 years). After an overview, a module profile is provided which charts the activities, and…

Project S.P.I.C.E.: Special Partnership in Career Education. Decision Making Teaching Module.

ERIC Educational Resources Information Center

Emerson, Debby H.; And Others

The decision making teaching module is one of a series of six modules prepared by Project SPICE (Special Partnership in Career Education) as a means of providing career awareness information to educable mentally handicapped students (ages 11-to-13 years). After an overview, a module profile is provided which charts the units, the activities in…

Early Intervention Special Instructors and Service Coordinators in One State: Characteristics, Professional Development, and Needed Lines of Inquiry

ERIC Educational Resources Information Center

Edwards, Nicole Megan; Gallagher, Peggy A.

2016-01-01

The success of Early Intervention (EI) programs (Part C, IDEA [Individuals with Disabilities Education Improvement Act of 2004]) for infants and toddlers with special needs (birth to 36 months) is largely influenced by the quality of direct service providers. Little is known, however, about characteristics of providers or involvement in training…

A Very Special Education

ERIC Educational Resources Information Center

Jones, Hilda B.

1973-01-01

Granite School District, a suburb of Salt Lake City, Utah, has a staff of 349 teachers and other professional personnel who provide career education and job experience for more than 5,000 special children. (DS)

Find a NCCAOM Certified Practitioner

MedlinePlus

... Diplomate Fees Forms and Documents Publications Academy Website Ethics and Disciplinary Review Special Events Applicants Applicants Home ... Fees Forms and Documents ADA Accommodations State Licensure Ethics and Disciplinary Review Applicants Special Events PDA Providers ...

ALS (Amyotrophic Lateral Sclerosis)

MedlinePlus

... design an individualized treatment plan and provide special equipment aimed at keeping people as mobile, comfortable, and ... drug interactions. Physical therapy Physical therapy and special equipment can enhance an individual’s independence and safety throughout ...

[Communication of psychiatric hospitals' specialization].

PubMed

Thielscher, Christian; Kox, Andreas; Schütte, Michael

2010-09-01

To analyze whether specialization of psychiatric hospitals results in quality improvement, and whether it can and should be measured and communicated to patients and ambulatory care physicians. Depth interviews with key deciders in the German psychiatric care system. There are several specializations within the system of psychiatric hospital care which can be communicated to patients and physicians; this would facilitate choice of hospital. There is no national database available yet. Data collection and communication as provided by an independent organization would improve knowledge about hospital specialization.

Increased pediatric sub-specialization is associated with decreased surgical complication rates for inpatient pediatric urology procedures

PubMed Central

Tejwani, R.; Wang, H-H. S.; Young, B. J.; Greene, N. H.; Wolf, S.; Wiener, J. S.; Routh, J. C.

2016-01-01

Summary Introduction Increased case volumes and training are associated with better surgical outcomes. However, the impact of pediatric urology sub-specialization on perioperative complication rates is unknown. Objectives To determine the presence and magnitude of difference in rates of common postoperative complications for elective pediatric urology procedures between specialization levels of urologic surgeons. The Nationwide Inpatient Sample (NIS), a nationally representative administrative database, was used. Study Design The NIS (1998–2009) was retrospectively reviewed for pediatric (≤18 years) admissions, using ICD-9-CM codes to identify urologic surgeries and National Surgical Quality Improvement Program (NSQIP) inpatient postoperative complications. Degree of pediatric sub-specialization was calculated using a Pediatric Proportion Index (PPI), defined as the ratio of children to total patients operated on by each provider. The providers were grouped into PPI quartiles: Q1, 0–25% specialization; Q2, 25–50%; Q3, 50–75%; Q4, 75–100%. Weighted multivariate analysis was performed to test for associations between PPI and surgical complications. Results A total of 71,479 weighted inpatient admissions were identified. Patient age decreased with increasing specialization: Q1, 7.9 vs Q2, 4.8 vs Q3, 4.8 vs Q4, 4.6 years, P<0.01). Specialization was not associated with race (P>0.20), gender (P>0.50), or comorbidity scores (P=0.10). Mortality (1.5% vs 0.2% vs 0.3% vs 0.4%, P<0.01) and complication rates (15.5% vs 11.7% vs 9.6% vs 10.9%, P<0.0001) both decreased with increasing specialization. Patients treated by more highly specialized surgeons incurred slightly higher costs (Q2, +4%; Q3, +1%; Q4 + 2%) but experienced shorter length of hospital stay (Q2, –5%; Q3, –10%; Q4, –3%) compared with the least specialized providers. A greater proportion of patients treated by Q1 and Q3 specialized urologists had CCS ≥2 than those seen by Q2 or Q4 urologists (12.5% and 12.2%, respectively vs 8.4% and 10.9%, respectively, P=0.04). Adjusting for confounding effects, increased pediatric specialization was associated with decreased postoperative complications: Q2 OR 0.78, CI 0.58–1.05; Q3 OR 0.60, CI 0.44–0.84; Q4 OR 0.70, CI 0.58–0.84; P<0.01. Discussion Providers with proportionally higher volumes of pediatric patients achieved better postoperative outcomes than their less sub-specialized counterparts. This may have arisen from increased exposure to pediatric anatomy and physiology, and greater familiarity with pediatric techniques. Limitation The NIS admission-based retrospective design did not enable assessment of long-term outcomes, repeated admissions, or to track a particular patient across time. The study was similarly limited in evaluating the effect of pre-surgical referral patterns on patient distributions. Conclusions Increased pediatric sub-specialization among urologists was associated with a decreased risk of mortality and surgical complications in children undergoing inpatient urologic procedures. PMID:27363329

Increased pediatric sub-specialization is associated with decreased surgical complication rates for inpatient pediatric urology procedures.

PubMed

Tejwani, R; Wang, H-H S; Young, B J; Greene, N H; Wolf, S; Wiener, J S; Routh, J C

2016-12-01

Increased case volumes and training are associated with better surgical outcomes. However, the impact of pediatric urology sub-specialization on perioperative complication rates is unknown. To determine the presence and magnitude of difference in rates of common postoperative complications for elective pediatric urology procedures between specialization levels of urologic surgeons. The Nationwide Inpatient Sample (NIS), a nationally representative administrative database, was used. The NIS (1998-2009) was retrospectively reviewed for pediatric (≤18 years) admissions, using ICD-9-CM codes to identify urologic surgeries and National Surgical Quality Improvement Program (NSQIP) inpatient postoperative complications. Degree of pediatric sub-specialization was calculated using a Pediatric Proportion Index (PPI), defined as the ratio of children to total patients operated on by each provider. The providers were grouped into PPI quartiles: Q1, 0-25% specialization; Q2, 25-50%; Q3, 50-75%; Q4, 75-100%. Weighted multivariate analysis was performed to test for associations between PPI and surgical complications. A total of 71,479 weighted inpatient admissions were identified. Patient age decreased with increasing specialization: Q1, 7.9 vs Q2, 4.8 vs Q3, 4.8 vs Q4, 4.6 years, P < 0.01). Specialization was not associated with race (P > 0.20), gender (P > 0.50), or comorbidity scores (P = 0.10). Mortality (1.5% vs 0.2% vs 0.3% vs 0.4%, P < 0.01) and complication rates (15.5% vs 11.7% vs 9.6% vs 10.9%, P < 0.0001) both decreased with increasing specialization. Patients treated by more highly specialized surgeons incurred slightly higher costs (Q2, +4%; Q3, +1%; Q4 + 2%) but experienced shorter length of hospital stay (Q2, -5%; Q3, -10%; Q4, -3%) compared with the least specialized providers. A greater proportion of patients treated by Q1 and Q3 specialized urologists had CCS ≥2 than those seen by Q2 or Q4 urologists (12.5% and 12.2%, respectively vs 8.4% and 10.9%, respectively, P = 0.04). Adjusting for confounding effects, increased pediatric specialization was associated with decreased postoperative complications: Q2 OR 0.78, CI 0.58-1.05; Q3 OR 0.60, CI 0.44-0.84; Q4 OR 0.70, CI 0.58-0.84; P < 0.01. Providers with proportionally higher volumes of pediatric patients achieved better postoperative outcomes than their less sub-specialized counterparts. This may have arisen from increased exposure to pediatric anatomy and physiology, and greater familiarity with pediatric techniques. The NIS admission-based retrospective design did not enable assessment of long-term outcomes, repeated admissions, or to track a particular patient across time. The study was similarly limited in evaluating the effect of pre-surgical referral patterns on patient distributions. Increased pediatric sub-specialization among urologists was associated with a decreased risk of mortality and surgical complications in children undergoing inpatient urologic procedures. Copyright © 2016 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

Funding Transparency under ESSA. Special Report

ERIC Educational Resources Information Center

Woods, Julie Rowland

2018-01-01

This special report explains the new requirements states have in reporting per-pupil expenditures under the Every Student Succeeds Act. It also provides key considerations for states and information about technical assistance and support.

49 CFR 178.3 - Marking of packagings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... packaging to provide adequate accessibility, permanency, contrast, and legibility so as to be readily... manufacturing special permit unless that person is the holder of or a party to that special permit, an agent of...

Charter School Directors' and Principals' Self-Reported Knowledge of Inclusive Aspects of Special Education

ERIC Educational Resources Information Center

Christensen, Jaime Dereta

2009-01-01

The purpose of this study was to determine the reported level of special education knowledge of Utah charter school principals/directors. In order for charter schools to provide a learning environment that is accommodating, accepting, and promotes the success of children with special needs a systems change may be in order. For the change to be…

Using PulpMotion Videos as Instructional Anchors for Pre-Service Teachers Learning about Early Childhood Special Education

ERIC Educational Resources Information Center

Chapman, Denise N. J.

2014-01-01

Providing pre-service early childhood general educators with a strong knowledge base of key aspects of early childhood special education is essential in the United States as US federal law mandates it. Specifically, the Individuals with Disabilities Education Act (IDEA) stipulates that children with special needs must to be placed in the least…

Multitasking Is Multitaxing: Why Special Educators Are Leaving the Field

ERIC Educational Resources Information Center

Kaff, Marilyn S.

2004-01-01

The purpose of the study was to provide insight into the inability to retain qualified special education teachers. Why do special educators say they want to leave? What conditions would encourage them to stay? Nearly half of the teachers reported they planned to leave the field in the next 5 years. They cited three areas of concern: administrative…

Access Skills. Vocational Readiness Skills Inventory for Special Needs Students. (Revised Entry Level Skills Inventory.) Missouri LINC.

ERIC Educational Resources Information Center

Cassity, Sandra; Boyer-Stephens, Arden

This manual is intended to assist special educators and vocational educators in determining the vocational readiness skills of special needs students. The information in this Missouri inventory is based on data provided by the Michigan Occupational Data Analysis System (ODAS) as a part of the Vocational-Technical Education Consortium of States…

Stories that Promote Understanding of Children with Special Needs: A Look at Autism Spectrum Disorders, Tourette Syndrome, Down Syndrome, and Attention Deficit/Hyperactivity Disorder

ERIC Educational Resources Information Center

Maples, Lucy; Applin, Janet L.

2009-01-01

This article takes on the issue of understanding children with special needs by providing an annotated bibliography of stories about children with special needs. Four areas are addressed: autism spectrum disorders, Down syndrome, Tourette syndrome, and Attention Deficit/Hyperactivity Disorder. Each area is described with its typical…

42 CFR 422.216 - Special rules for MA private fee-for-service plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules for MA private fee-for-service plans... Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and services that...

42 CFR 422.216 - Special rules for MA private fee-for-service plans.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules for MA private fee-for-service plans... Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and services that...

Developing a Specialized Vocabulary Word List in a Composition Culinary Course through Lecture Notes

ERIC Educational Resources Information Center

M.Nordin, N. R.; Stapa, S. H.; Darus, S.

2013-01-01

Learning to write in a composition culinary course is very challenging for L2 learners. The main barrier in writing proficiency within this discipline is the lack of vocabulary, specifically the lack of exposure towards specialized vocabulary. This study aims to provide a corpus of specialized vocabulary within a food writing course. By providing…

Que Sucede? Manual Informativo Sobre Rehabilitacion y Educacion Especial en Costa Rica (What's Happening? Informative Manual on Rehabilitation and Special Education in Costa Rica).

ERIC Educational Resources Information Center

de Mezerville, Gaston; And Others

The manual, in Spanish, provides descriptions of rehabilitation, medical, and special education services; centers and institutions which offer physical and mental rehabilitation services; and lists of professionals and advocacy organizations in Costa Rica. Part 1 includes an overview of rehabilitation and special education, a short history of…

Behavioral Disorders: Identification, Assessment, and Instruction of Students with EBD. Advances in Special Education. Volume 22

ERIC Educational Resources Information Center

Bakken, Jeffrey P., Ed.; Obiakor, Festus E., Ed.; Rotatori, Anthony F., Ed.

2012-01-01

Volumes 22 and 23 of "Advances in Special Education" address the current top perspectives and issues in the field of EBD by providing chapters written by active researchers and scholarly university professors who specialize in this area. Volume 22 first delineates legal issues, themes, and dimensions related to the historical development of the…

46 CFR 280.9 - Special rules for last year of ODS agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Special rules for last year of ODS agreement. 280.9... LINER OPERATORS § 280.9 Special rules for last year of ODS agreement. (a) Reduction in payment of ODS. ODS payable during the last year of any ODS agreement shall be reduced, as provided in paragraph (b...

A Study of West Virginia Elementary Special Education Teachers' Roles, Responsibilities, and Practices within a Multi-Tiered Instructional System: Implications for Policy and Practice

ERIC Educational Resources Information Center

Palenchar, Linda M.

2012-01-01

The purpose of the study was to provide a data-based description of West Virginia special education teachers' roles, responsibilities, and practices relevant to their participation in selected components of the Response to Intervention (RTI) process. Special educators' practices related to assessment, tiered instruction, decision making, and…

40 CFR 141.209 - Special notice for nitrate exceedances above MCL by non-community water systems (NCWS), where...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Special notice for nitrate exceedances... Drinking Water Violations § 141.209 Special notice for nitrate exceedances above MCL by non-community water... primacy agency under § 141.11(d) to exceed the nitrate MCL must provide notice to persons served according...

40 CFR 141.209 - Special notice for nitrate exceedances above MCL by non-community water systems (NCWS), where...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Special notice for nitrate exceedances... Water Violations § 141.209 Special notice for nitrate exceedances above MCL by non-community water... primacy agency under § 141.11(d) to exceed the nitrate MCL must provide notice to persons served according...

40 CFR 141.209 - Special notice for nitrate exceedances above MCL by non-community water systems (NCWS), where...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 24 2012-07-01 2012-07-01 false Special notice for nitrate exceedances... Water Violations § 141.209 Special notice for nitrate exceedances above MCL by non-community water... primacy agency under § 141.11(d) to exceed the nitrate MCL must provide notice to persons served according...

26 CFR 31.3406(h)-2 - Special rules.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Special rules. 31.3406(h)-2 Section 31.3406(h... Collection of Income Tax at Source § 31.3406(h)-2 Special rules. (a) Joint accounts—(1) Relevant name and... be subject to the penalty under section 6705 (failure of a broker to provide notice to a payor). (h...

The philosophical aspects of hate crime and hate crime legislation: introducing the special section on the philosophy of hate crime.

PubMed

Brax, David; Munthe, Christian

2015-06-01

In this introduction to the special symposium on the philosophy of hate crime, we provide an overview of the main philosophical aspects of hate crime and hate crime legislation. We point out that there are two overarching philosophical issues that span over the literature: the Conceptual Question--concerning what hate crime is--and the Normative Question--concerning the status of hate crimes and the justification of hate crime legislation. We also provide brief summaries of the articles in the special section and point to their relations to the broader themes. © The Author(s) 2014.

Method for cancelling expansion waves in a wave rotor

NASA Astrophysics Data System (ADS)

Paxson, Daniel E.

1994-03-01

A wave rotor system includes a wave rotor coupled to first and second end plates. Special ports are provided, one in each of the first and second end plates, to cancel expansion waves generated by the release of working fluid from the wave rotor. One of the expansion waves is reflected in the wave rotor from a reflecting portion, and provided to the special port in the second end plate. Fluid present at the special port in the second end plate has a stagnation pressure and mass flow which is substantially the same as that of the cells of the wave rotor communicating with such special port. This allows for cancellation of the expansion wave generated by the release of working fluid from the wave rotor. The special port in the second end plate has a first end corresponding substantially to the head of the expansion wave, and a second end corresponding substantially to the tail of the expansion wave. Also, the special port is configured to continually change along the circumference of the second end plate to affect expansion wave cancellation. An expansion wave generated by a second release of working fluid from the wave rotor is cancelled in a similar manner to that described above using a special port in the first end plate. Preferably the cycle of operation of the wave rotor system is designed so that the stagnation pressure and mass flow of the fluid present at the special ports is the same so that the special ports may be connected by a common duct.

System and method for cancelling expansion waves in a wave rotor

NASA Astrophysics Data System (ADS)

Paxson, Daniel E.

1993-12-01

A wave rotor system that is comprised of a wave rotor coupled to first and second plates is described. Special ports are provided, one in each of the first and second end plates, to cancel expansion waves generated by the release of working fluid from the wave rotor. One of the expansion waves is reflected in the wave rotor from a reflecting portion and provided to the special port in the second end plate. Fluid present at the special port in the second end plate has a stagnation pressure and mass flow which is the same as that of the cells of the wave rotor communicating with such special port. This allows for cancellation of the expansion wave generated by the release of working fluid from the wave rotor. The special port in the second end plate has a first end corresponding to the head of the expansion wave and a second end corresponding to the tail of the expansion wave. Also, the special port is configured to continually change along the circumference of the second end plate to affect expansion wave cancellation. An expansion wave generated by a second release of working fluid from the wave rotor is cancelled in a similar manner to that described above using a special port in the first end plate. The cycle of operation of the wave rotor system is designed so that the stagnation pressure and mass flow of the fluid present at the special ports is the same so that the special ports may be connected by a common duct.

IDEA at Age Forty: Weathering Common Core Standards and Data Driven Decision Making

ERIC Educational Resources Information Center

Bicehouse, Vaughn; Faieta, Jean

2017-01-01

Special education, a discipline that aims to provide specialized instruction to meet the unique needs of each child with a disability, has turned 40 years old in the United States. Ever since the passage of the Education for All Handicapped Children Act (P.L. 94-142) in 1975, every state has been directed to provide a free and appropriate…

Inclusion and the Special Educational Needs (SEN) Resource Base in Mainstream Schools: Physical Factors to Maximise Effectiveness

ERIC Educational Resources Information Center

McAllister, Keith; Hadjri, Karim

2013-01-01

As a society, we have a responsibility to provide an inclusive built environment. As part of the need to promote inclusion, there is now a growing trend to place pupils with special educational needs (SEN) into a mainstream school setting. This is often facilitated by providing a specialist SEN resource base located within the mainstream school.…

A tertiary care-primary care partnership model for medically complex and fragile children and youth with special health care needs.

PubMed

Gordon, John B; Colby, Holly H; Bartelt, Tera; Jablonski, Debra; Krauthoefer, Mary L; Havens, Peter

2007-10-01

To evaluate the impact of a tertiary care center special needs program that partners with families and primary care physicians to ensure seamless inpatient and outpatient care and assist in providing medical homes. Up to 3 years of preenrollment and postenrollment data were compared for patients in the special needs program from July 1, 2002, through June 30, 2005. A tertiary care center pediatric hospital and medical school serving urban and rural patients. A total of 227 of 230 medically complex and fragile children and youth with special needs who had a wide range of chronic disorders and were enrolled in the special needs program. Care coordination provided by a special needs program pediatric nurse case manager with or without a special needs program physician. Preenrollment and postenrollment tertiary care center resource utilization, charges, and payments. A statistically significant decrease was found in the number of hospitalizations, number of hospital days, and tertiary care center charges and payments, and an increase was found in the use of outpatient services. Aggregate data revealed a decrease in hospital days from 7926 to 3831, an increase in clinic visits from 3150 to 5420, and a decrease in tertiary care center payments of $10.7 million. The special needs program budget for fiscal year 2005 had a deficit of $400,000. This tertiary care-primary care partnership model improved health care and reduced costs with relatively modest institutional support.

LISTS : Transportation Brokerage for the Elderly and Handicapped in Lancaster, PA

DOT National Transportation Integrated Search

1984-06-01

The Lancaster Integrated Specialized Transportation System (LISTS) is a transportation broker serving Lancaster County, Pennsylvania. The system was initiated in 1977 and matches the resources of private, specialized transportation providers with the...

47 CFR 78.33 - Special temporary authority.

Code of Federal Regulations, 2010 CFR

2010-10-01

... facilities, a request may be made for special temporary authority to install and operate new equipment or to... with § 78.18: Provided, however, That in the case of events of widespread interest and importance that...

Special Education through Neighbourhood Centers in Algeria.

ERIC Educational Resources Information Center

Boucebci, Mahfoud

1981-01-01

The article provides a survey of special education needs in Algeria with emphasis on the role of neighborhood centers which involve parents in the education of mentally handicapped children. Journal availability: see EC 133 861. (DB)

Paratransit, Inc., Special Transportation Service in Sacramento

DOT National Transportation Integrated Search

1981-07-01

Paratransit, Inc., a nonprofit corporation created in July, 1978, offers special transportation for handicapped and elderly persons in the Sacramento area. A variety of service agreements were negotiated with social service agencies for providing tra...

Evacuating populations with special needs

DOT National Transportation Integrated Search

2009-04-01

Evacuation operations are conducted under the authority of, and based on decisions by, local and state authorities. The purpose of this primer, Evacuating Populations with Special Needs, is to provide local and state emergency managers, government of...

Foreword to the special issue on intercalibration of satellite instruments

USGS Publications Warehouse

Chander, Gyanesh; Hewison, T.J.; Fox, Nigel; Wu, Xiangqian; Xiong, Xiaoxiong; Blackwell, William J.

2013-01-01

This forty papers in this special issue focus on how intercalibration and comparison between sensors can provide an effective and convenient means of verifying their postlaunch performance and correcting their measurement differences.

Introduction to the Special Section on Teaching, Training, and Supervision in Personality and Psychological Assessment.

PubMed

Smith, Justin D

2017-01-01

This special section contains empirical and conceptual articles pertaining to the broad topic of teaching, training, and supervision of assessment. Despite some evidence of a decline in recent decades, assessment remains a defining practice of professional psychologists in many subfields, including clinical, counseling, school, and neuropsychology, that consumes a consequential proportion of their time. To restore assessment to its rightful place of prominence, a clear agenda needs to be developed for advancing teaching and training methods, increasing instruction to state-of-the-art methods, and defining aims that could be elucidated through empirical inquiry. The 7 articles in this special section provide a developmental perspective of these issues that collectively provide practical tools for instructors and begin to set the stage for a research agenda in this somewhat neglected area of study that is vital to the identity of professional psychology. Additionally, 2 comments are provided by distinguished figures in the field concerning the implications of the articles in the special section to health services psychology and the competencies-based movement in applied psychology.

Childhood Placement in Special Education and Adult Well-Being.

PubMed

Chesmore, Ashley A; Ou, Suh-Ruu; Reynolds, Arthur J

2016-08-01

The present study investigates the relationship between childhood placement in special education and adult well-being among 1,377 low-income, minority children participating in the Chicago Longitudinal Study. Roughly 16% of the sample received special education services in grades 1-8. After accounting for sociodemographic factors and early academic achievement, children receiving special education services tended to have lower rates of high school completion and fewer years of education, as well as greater rates of incarceration, substance misuse, and depression. Eighth grade academic achievement significantly mediated the association between childhood placement in special education and adult well-being outcomes. The study contributes to the literature by providing support for a pathway from childhood special education placement to adult outcomes among an inner-city minority cohort.

Medical devices; hematology and pathology devices; classification of cord blood processing system and storage container. Final rule.

PubMed

2007-02-01

The Food and Drug Administration (FDA) is classifying a cord blood processing system and storage container into class II (special controls). The special control that will apply to this device is the guidance document entitled "Class II Special Controls Guidance Document: Cord Blood Processing System and Storage Container." FDA is classifying this device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of this device. Elsewhere in this issue of the Federal Register, FDA is announcing the availability of the guidance document that will serve as the special control for this device.

Pediatric Dentistry Specialty as Part of a Longer Continuum of Care: A Commentary.

PubMed

Waldman, H Barry; Rader, Rick; Sulkes, Stephen; Perlman, Steven P

The transition of teenagers with special needs to young adulthood is a complex period for the children and their families. This transition is especially difficult when it comes to securing needed oral health care. The teenager is forced to transfer from the services of an age defined pediatric dental specialist with training to provide care for individuals with special needs, to 1) general practitioners with limited formal training and often unwillingness to provide care and 2) at a period when most states provide limited or lack of adult dental Medicaid programs. These issues and the need to expand pediatric dental specialist involvement in the general transitional period are reviewed. "Pediatric dentistry is an age-defined specialty that provides both primary and comprehensive preventive and therapeutic oral health care for infants and children through adolescence, including those with special health care needs."(1) "Our system of preparing and maintaining our abilities to provide oral health services for an increasing diverse population must be brought up to date to meet the challenges posed by the treatment of young adults with disabilities."(2) "Most responding dentists (to a national study of pediatric dentists) helped adolescents with and without SHCNs (Special Health Care Needs) make the transition into adult care, but the major barrier was the availability of general dentists and specialists."(3).

The Comparison of Special Education between Thailand and the United States: Inclusion and Support for Children with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Hill, Doris Adams; Sukbunpant, Sasipin

2013-01-01

The history of special education in the United States and Thailand has followed a similar path in many ways. Both countries made compulsory education mandatory to move in a positive direction in providing special education services to children with disabilities including the provision of services for children with ASD or Autism. In Thailand,…

75 FR 30296 - Special Local Regulation for Marine Event; Maryland Swim for Life, Chester River, Chestertown, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

...-AA08 Special Local Regulation for Marine Event; Maryland Swim for Life, Chester River, Chestertown, MD... Chestertown, MD during the Maryland Swim for Life. Special local regulations are necessary to provide for the safety of life on navigable waters during the event. DATES: This rule is effective from 5:30 a.m. to 2:30...

2015 Cataloging Hidden Special Collections and Archives Unconference and Symposium: Innovation, Collaboration, and Models. Proceedings of the CLIR Cataloging Hidden Special Collections and Archives Symposium (Philadelphia, Pennsylvania, March 12-13, 2015)

ERIC Educational Resources Information Center

Oestreicher, Cheryl, Ed.

2015-01-01

The 2015 CLIR Unconference & Symposium was the capstone event to seven years of grant funding through CLIR's Cataloging Hidden Special Collections and Archives program. These proceedings group presentations by theme. Collaborations provides examples of multi-institutional projects, including one international collaboration; Student and Faculty…

Rural/Urban Differences in Barriers to and Burden of Care for Children with Special Health Care Needs

ERIC Educational Resources Information Center

Skinner, Asheley Cockrell; Slifkin, Rebecca T.

2007-01-01

Purpose: To examine the barriers and difficulties experienced by rural families of children with special health care needs (CSHCN) in caring for their children. Methods: The National Survey of Children with Special Health Care Needs was used to examine rural-urban differences in types of providers used, reasons CSHCN had unmet health care needs,…

Providing Immediate Feedback to Co-Teachers through Bug-in-Ear Technology: An Effective Method of Peer Coaching in Inclusion Classrooms

ERIC Educational Resources Information Center

Scheeler, Mary Catherine; Congdon, Marissa; Stansbery, Sam

2010-01-01

More children with special needs are educated in general education classrooms than ever before. Ideally, special education and general education teachers work together in these settings as instructional teams, but a "one teaching, one assisting" model is often in place with the special education teacher assuming a subordinate role. As such, the…

The Special Education Teacher as an Instructional Designer. Rational, Content, and Strategy for an Innovative Individualized Course on Instructional Design in Special Education. Working Paper 9.14.

ERIC Educational Resources Information Center

Thiagarajan, Sivasailam

Provided are the rationale, content and strategy for an introductory course in instructional design for special education teachers. The teacher's need for varied competencies in instructional design, management and interaction are discussed. It is recommended that teacher training include development of such design skills as task analysis, learner…

The Bureau of Indian Affairs is Slow in Providing Special Education Services to All Handicapped Indian Children.

ERIC Educational Resources Information Center

Comptroller General of the U.S., Washington, DC.

Many handicapped Indian children in Bureau of Indian Affairs (BIA) schools are not receiving the benefits of special education services due to problems caused by poor leadership and a lack of emphasis on the program. Because of the late and incomplete evaluation of students, too few special education teachers have been hired, and funds that should…

47 CFR 80.1061 - Special requirements for 406.0-406.1 MHz EPIRB stations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... requirements contained in §§ 2.925 and 2.926 of this chapter, each 406.0-406.1 MHz EPIRB must be provided on... 47 Telecommunication 5 2011-10-01 2011-10-01 false Special requirements for 406.0-406.1 MHz EPIRB... Radiobeacons (EPIRB's) § 80.1061 Special requirements for 406.0-406.1 MHz EPIRB stations. (a) Notwithstanding...

"My Eyes Went Wide Open"--An Evaluation of the Special Needs Education Awareness Course at Molepolole College of Education, Botswana

ERIC Educational Resources Information Center

Dart, Gareth

2006-01-01

This article is an evaluation of the special needs education awareness course run at Molepolole College of Education, Botswana. The course directly reflects the Government of Botswana's policy on special education and seeks to provide students with a wide range of skills and knowledge to help them identify and support pupils with a variety of…

Evaluating "Blair's Educational Legacy?": Some Comments on the Special Issue of "Oxford Review of Education"

ERIC Educational Resources Information Center

Whitty, Geoff

2009-01-01

The December 2008 special issue of the "Oxford Review of Education" provided a review of education policy during Tony Blair's tenure as Prime Minister. This paper forms a response to the ten contributions to that special issue and discusses some of the issues raised in them. While a few positive aspects of education under New Labour were…

The Effects of Two Schedules of Instruction with Constant Time Delay on the Receptive Word Learning Skills of Preschool Children with Developmental Delays

ERIC Educational Resources Information Center

Spino, Margie A.

2013-01-01

Young children with special needs in inclusive settings may be provided special education services by itinerant early childhood special education (ECSE) teachers. These teachers typically travel to the community-based preschool program and work with a child for about 1 hour, 1 day each week. Research suggests that once itinerant ECSE teachers…

Special school teachers require more goal-oriented collaboration with psychiatric professionals in Northern Finland.

PubMed

Pönkkö, Maija-Leena; Taanila, Anja; Ebeling, Hanna

2003-03-01

The problems of children and adolescents have increased in number and severity during the last years. The purpose of this study was to elicit the views of special school teachers in the Oulu Province in Finland concerning their pupils' problems and the need, use and adequacy of relevant psychiatric services. The information was collected from the Northern Ostrobothnia Hospital District in 1998 in Finland and responses were obtained from the 37 (97.4%) special schools. The data were analysed using the content analysis method. Special-needs pupils had various behavioural and emotional problems that made it difficult for them to learn and for the teachers to teach. According to the teachers, the major obstacles in the process of helping special-needs pupils were the delayed admission for treatment and the lack of information necessary for the pupils' school work and goal-oriented aftercare, although there were also favourable experiences of functional co-operation and availability of useful information. Some schools lacked a reliable network for helping pupilsand supporting teachers. The Finnish legislation on basic education obliges the providers of education to provide rehabilitation in connection with special education and to arrange relevant development, counselling and support services. The rehabilitation of special-need pupils and the collaboration between school and mental health authorities is not optimally realised in spite of the legislation.

The 1986 Get Away Special Experimenter's Symposium

NASA Technical Reports Server (NTRS)

Thomas, Lawrence R. (Editor); Mosier, Frances L. (Editor)

1987-01-01

The 1986 Get Away Special (GAS) Experimenter's Symposium will provide a formal opportunity for GAS Experimenter's to share the results of their projects. The focus of this symposium is on payloads that will be flown in the future.

Special issue : neck injuries and rear-end crashes

DOT National Transportation Integrated Search

1999-05-22

Research has indicated that head restraints could prevent whiplash injuries in rear-end crashes, but so far the existing head restraints do not satisfactorily prevent whiplash injuries. This special issue of 'Status Report' first provides a snapshot ...

Theme: Teaching Academically Disadvantaged Students.

ERIC Educational Resources Information Center

Iverson, Maynard J.; And Others

1993-01-01

Includes "Will We Serve the Academically Disadvantaged?" (Iverson); "Using Centers of Learning to Reach Academically Disadvantaged Students" (Gentry); "Georgia's Special Lamb Project Adoption Program" (Farmer); "Teacher Expectations" (Powers); "Providing Instruction for Special Populations" (Jewell); and "The Educational Reform Movement and…

Special Education: A Microcosm of Bureaucracy. Part Two: The Elements of the System

ERIC Educational Resources Information Center

Clark, Ann D.

1971-01-01

Delineates a case study of special education that provides a unique microcosm of the emergence of an educational subsystem with inherent and forceful bureaucratic controls that were present from its inception. (Author)

Lift : Special Needs Transportation in Portland, Oregon

DOT National Transportation Integrated Search

1978-01-01

The report covers Portland, Oregon's Special Needs Transportation (SNT) project - the Lift - during its first year of operation. The purposes of this UMTA Service and Methods Demonstration (SMD) is to: (1) test a transit operator's ability to provide...

Effect of assistive technology in a public school setting.

PubMed

Watson, Anne H; Ito, Max; Smith, Roger O; Andersen, Lori T

2010-01-01

The Individuals With Disabilities Education Improvement Act of 2004 (IDEA) requires assistive technology (AT) be considered at the yearly individualized education program (IEP) meeting of every student in special education. IDEA also directs that AT be implemented on the basis of peer-reviewed literature despite a paucity of research on AT's effectiveness in the public schools. This repeated-measures quasi-experimental study explored AT's effect in a public school special education setting. Participants (N=13) were a heterogeneous group of students in 1 school system who had newly provided AT to address academic and communication goals in one school year. Results suggest that relative to other interventions, AT provided by a multidisciplinary team may have a significant effect on IEP goal improvement (t[12] = 5.54, p= .00) for students in special education (F[2] = 9.35, p= .00), which may support AT's use in special education by occupational therapists as directed by IDEA.

Answers to Questions Frequently Asked About the Classified Student. A Professional Supplement Provided through the Central Burlington County Region for Special Education. Special Education Information Series. Booklet #5.

ERIC Educational Resources Information Center

Nissman, Blossom S.

This booklet provides answers to questions that may arise when learning or socially disabled children are placed in regular classrooms. The introduction gives the background of classifying students in the New Jersey school system and lists the twelve classification categories: (1) emotionally disturbed; (2) neurologically impaired; (3) trainable…