27 CFR 73.31 - May I submit forms electronically to TTB?

Code of Federal Regulations, 2014 CFR

2014-04-01

...; ELECTRONIC SUBMISSION OF FORMS Electronic Filing of Documents with TTB § 73.31 May I submit forms... above; (c) You submit the electronic form to an electronic document receiving system that we have... submit the form through an electronic document receiving system that TTB has designated for the receipt...

Department of the Air Force Justification of Estimates for Fiscal Years 1992/1993 Biennial Budget Estimates Submitted to Congress February 1991: Operation and Maintenance, Air Force. Volume 1

DTIC Science & Technology

1991-02-01

0- 04 (U *-( t)4C 41 44. 0.cU 00 1. E ) --- 0.- .0 0cc0 "a 40’. w-(. )( vi C.. 0 -C 00 r.SI. C -r. 00 Ccto 0(a 0 0 4 0Z.. 9 " 0 0 0 0 ~ -. 4 N000.to...4)" Q.0)L C 0) U LO. 0 -0 0-)Ŕ 0 C C 0 0 4)CU) C - C U) cCto - UI) - % $ c z- -O CU 0.0. 0)- C Ŕ T 0.Q’- - 0- Om 0 a)0 c 0 ) co’ 0 > . co C.C C

Cancer related gene alterations can be detected with next-generation sequencing analysis of bile in diffusely infiltrating type cholangiocarcinoma.

PubMed

Lee, Chang Hun; Wang, Hong En; Seo, Seung Young; Kim, Seong Hun; Kim, In Hee; Kim, Sang Wook; Lee, Soo Teik; Kim, Dae Ghon; Han, Myung Kwan; Lee, Seung Ok

2016-08-01

Genome-wide association study in diffusely infiltrating type cholangiocarcinoma (CC) can be limited due to the difficulty of obtaining tumor tissue. We aimed to evaluate the genomic alterations of diffusely infiltrating type CC using next-generation sequencing (NGS) of bile and to compare the variations with those of mass-forming type CC. A total of 24 bile samples obtained during endoscopic retrograde cholangiopancreatography (ERCP) and 17 surgically obtained tumor tissue samples were evaluated. Buffy coat and normal tissue samples were used as controls for a somatic mutation analysis. After extraction of genomic DNA, NGS analysis was performed for 48 cancer related genes. There were 27 men and 14 women with a mean age of 65.0±11.8years. The amount of extracted genomic DNA from 3cm(3) of bile was 66.0±84.7μg and revealed a high depth of sequencing coverage. All of the patients had genomic variations, with an average number of 19.4±2.8 and 22.3±3.3 alterations per patient from the bile and tumor tissue, respectively. After filtering process, damaging SNPs (8 sites for each type of CC) were predicted by analyzing tools, and their target genes showed relevant differences between the diffusely infiltrating and mass-forming type CC. Finally, in somatic mutation analysis, tumor-normal paired 14 tissue and 6 bile samples were analyzed, genomic alterations of EGFR, FGFR1, ABL1, PIK3CA, and CDKN2A gene were seen in the diffusely infiltrating type CC, and TP53, KRAS, APC, GNA11, ERBB4, ATM, SMAD4, BRAF, and IDH1 were altered in the mass-forming type CC group. STK11, GNAQ, RB1, KDR, and SMO genes were revealed in both groups. The NGS analysis was feasible with bile sample and diffusely infiltrating type CC revealed genetic differences compared with mass-forming type CC. Genome-wide association study could be performed using bile sample in the patients with CC undergoing ERCP and a different genetic approach for accurate diagnosis, pathogenesis study, and targeted therapy will be needed in diffusely infiltrating type CC. Copyright © 2016 Elsevier Inc. All rights reserved.

Quantum cluster theory for the polarizable continuum model. I. The CCSD level with analytical first and second derivatives.

PubMed

Cammi, R

2009-10-28

We present a general formulation of the coupled-cluster (CC) theory for a molecular solute described within the framework of the polarizable continuum model (PCM). The PCM-CC theory is derived in its complete form, called PTDE scheme, in which the correlated electronic density is used to have a self-consistent reaction field, and in an approximate form, called PTE scheme, in which the PCM-CC equations are solved assuming the fixed Hartree-Fock solvent reaction field. Explicit forms for the PCM-CC-PTDE equations are derived at the single and double (CCSD) excitation level of the cluster operator. At the same level, explicit equations for the analytical first derivatives of the PCM basic energy functional are presented, and analytical second derivatives are also discussed. The corresponding PCM-CCSD-PTE equations are given as a special case of the full theory.

30 CFR 1218.580 - When do I submit Form ONRR-4444?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false When do I submit Form ONRR-4444? 1218.580... Service of Official Correspondence § 1218.580 When do I submit Form ONRR-4444? Initially, you must submit Form ONRR-4444 by November 29, 2006, and subsequently, within 2 weeks of any change of your address. ...

30 CFR 1218.580 - When do I submit Form MMS-4444?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false When do I submit Form MMS-4444? 1218.580... Service of Official Correspondence § 1218.580 When do I submit Form MMS-4444? Initially, you must submit Form MMS-4444 by November 29, 2006, and subsequently, within 2 weeks of any change of your address. ...

30 CFR 218.580 - When do I submit Form MMS-4444?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When do I submit Form MMS-4444? 218.580 Section 218.580 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE... Correspondence § 218.580 When do I submit Form MMS-4444? Initially, you must submit MMS Form-4444 by November 29...

30 CFR 1218.580 - When do I submit Form MMS-4444?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false When do I submit Form MMS-4444? 1218.580... Service of Official Correspondence § 1218.580 When do I submit Form MMS-4444? Initially, you must submit Form MMS-4444 by November 29, 2006, and subsequently, within 2 weeks of any change of your address. ...

30 CFR 1218.580 - When do I submit Form ONRR-4444?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false When do I submit Form ONRR-4444? 1218.580... Service of Official Correspondence § 1218.580 When do I submit Form ONRR-4444? Initially, you must submit Form ONRR-4444 by November 29, 2006, and subsequently, within 2 weeks of any change of your address. ...

Interannual Variability of Tehuantepec Eddies

DTIC Science & Technology

2006-01-01

NRL) Layered Ocean Model (NLOM) results Alaska and California and in the regions close to Aca- pulco, Cabo Corrientes , and the Maria Islands [Melsom...IDepartment of Marine Sciences, University of Georgia, Athens, Cabo Corrientes and the Maria Islands, Mexico, submitted Georgia, USA. to Journal of...Tehuantepec (GT), Acapulco (ACA), Cabo Corrientes (CC), and Maria Islands (NM1) are indicated. The magenta box in Figure 13h indicates the area where

30 CFR 1210.201 - How do I submit Form MMS-4430, Solid Minerals Production and Royalty Report?

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Instructions for completing and submitting Form MMS-4430 are available on our Internet reporting web site or you may contact us toll free at 1-888-201-6416. (b) When to submit. (1) Unless your lease terms... month. (c) How to submit. (1) You must submit Form MMS-4430 electronically using our Internet reporting...

Fatty acid composition of porcine cumulus oocyte complexes (COC) during maturation: effect of the lipid modulators trans-10, cis-12 conjugated linoleic acid (t10,c12 CLA) and forskolin.

PubMed

Prates, E G; Alves, S P; Marques, C C; Baptista, M C; Horta, A E M; Bessa, R J B; Pereira, R M

2013-05-01

The effect of maturation and of two lipid modulators supplementation along in vitro maturation (IVM) on fatty acid (FA) and dimethylacetal (DMA) composition of porcine cumulus oocyte complexes (COC) were studied. Abattoir-derived immature COC were analyzed for FA and DMA or submitted to IVM as follows: control group; t10,c12 CLA group, t10,c12 CLA supplementation for 44 h; Forskolin group, forskolin supplementation during the initial 2 h; t10,c12 CLA + forskolin group, t10,c12 CLA for 44 h and forskolin for just 2h. Each experimental group had five replicates. FA analysis of oocytes, cumulus cells (CC), follicular fluid, and culture media were performed by gas-liquid chromatography. Oocytes and their CC had different FA composition. Oocytes were richer in saturated FA (SFA) preferentially maintaining their FA profile during maturation. Mature CC had the highest polyunsaturated FA (PUFA) content. Five individual and total SFA, and monounsaturated FA (MUFA), notably oleic acid (c9-18:1), percentages were lower (P ≤ 0.023) in mature than in immature CC. t10,c12 CLA was accumulated by COC from t10,c12 CLA and t10,c12 CLA + forskolin groups, mostly in CC where MUFA and an eicosatrienoic isomer decreased (P ≤ 0.043). Nevertheless, PUFA or FA and DMA total content were not affected. Arachidonic acid was reduced in t10,c12 CLA + forskolin CC and hexadecanal-DMA-16:0 in t10,c12 CLA CC. Forskolin alone increased (P ≤ 0.043) c9-18:1 in oocytes. In conclusion, maturation process clearly changed porcine COC FA and DMA profiles, mostly of CC, also more susceptible to modifications induced by t10,c12 CLA. This possibility of manipulating COC lipid composition during IVM could be used to improve oocyte quality/cryopreservation efficiency.

(YIP-10) Enabling Dynamic Oxidation Mechanisms in Reverse Infiltrated Ultra-High Temperature Ceramic Coated C-C Composites for Application in Hypersonics

DTIC Science & Technology

2013-08-09

of Hf,Zr oxychloride hydrates, triethyl borate , and phenolic resin to form precipitate free sols that turn into stable gels with no catalyst addition...minutes, shows the glass -ceramic coating (that formed a shell upon cooling) was generated from within the UHTC filled C-C composite. Notice, in Figure...generation of the coating during high temperature exposure to oxygen. The formation of a ZrO2-SiO2 glass -ceramic coating on the C-C composite is believed to

Integrability of the coupled cubic-quintic complex Ginzburg-Landau equations and multiple-soliton solutions via mathematical methods

NASA Astrophysics Data System (ADS)

Selima, Ehab S.; Seadawy, Aly R.; Yao, Xiaohua; Essa, F. A.

2018-02-01

This paper is devoted to study the (1+1)-dimensional coupled cubic-quintic complex Ginzburg-Landau equations (cc-qcGLEs) with complex coefficients. This equation can be used to describe the nonlinear evolution of slowly varying envelopes of periodic spatial-temporal patterns in a convective binary fluid. Dispersion relation and properties of cc-qcGLEs are constructed. Painlevé analysis is used to check the integrability of cc-qcGLEs and to establish the Bäcklund transformation form. New traveling wave solutions and a general form of multiple-soliton solutions of cc-qcGLEs are obtained via the Bäcklund transformation and simplest equation method with Bernoulli, Riccati and Burgers’ equations as simplest equations.

30 CFR 1218.560 - How do I submit Form MMS-4444?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false How do I submit Form MMS-4444? 1218.560 Section... Service of Official Correspondence § 1218.560 How do I submit Form MMS-4444? A copy of Form MMS-4444 and..., signed form to the address designated on the Form MMS-4444 instructions. ...

Consideration of climate change on environmental impact assessment in Spain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Enríquez-de-Salamanca, Álvaro, E-mail: aenriquez@draba.org; Martín-Aranda, Rosa M., E-mail: rmartin@ccia.uned.es; Díaz-Sierra, Rubén, E-mail: sierra@dfmf.uned.es

Most of the projects subject to environmental impact assessment (EIA) are closely related to climate change, as they contribute to or are affected by it. The growing certainty about climate change and its impacts makes its consideration an essential part of the EIA process, as well as in strategic environmental assessment (SEA). This paper examines how climate change (CC) has been taken into account in EIA in Spain through the analysis of 1713 environmental records of decision (RODs) of projects submitted for EIA. In 2013 Spain approved one of the most advanced laws in terms of CC consideration in environmentalmore » assessment, although it had not yet accumulated extensive practice on the issue. This contrasts with the situation of countries like Canada or the USA, which have a significant body of experience without specific legal requirements. Only 14% of the RODs analysed included references to CC, and in more than half of the cases it was a mere citation. Thermal power plants, which are subject to specific GHG regulations, show the highest consideration, while transport infrastructures, which are important contributors to CC, show a very low consideration. Almost all the references are related to their contribution to CC, while consideration of the effects of CC is minimal. The increasingly common incorporation of CC into SEA, should not imply its exclusion from EIA, because both processes have different aims and uses. Including the obligation to consider CC in the EIA regulations is highly desirable, but probably not enough without other measures, such as practical guidance, training and motivational programmes for practitioners and evaluators. But even these actions cannot ensure effective and adequate assessments of CC. Probably more resources should be spent on creating greater awareness in all the agents involved in EIA. - Highlights: • We analyse how the climate change is considered in EIA in Spain. • Few projects seriously assess climate change. • Transport infrastructure projects barely consider climate change. • Assessing climate change in SEA should not imply that it is excluded from EIA.« less

C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products.

PubMed

Yokoyama, Kenichi; Lilla, Edward A

2018-04-10

Covering: up to the end of 2017C-C bond formations are frequently the key steps in cofactor and natural product biosynthesis. Historically, C-C bond formations were thought to proceed by two electron mechanisms, represented by Claisen condensation in fatty acids and polyketide biosynthesis. These types of mechanisms require activated substrates to create a nucleophile and an electrophile. More recently, increasing number of C-C bond formations catalyzed by radical SAM enzymes are being identified. These free radical mediated reactions can proceed between almost any sp3 and sp2 carbon centers, allowing introduction of C-C bonds at unconventional positions in metabolites. Therefore, free radical mediated C-C bond formations are frequently found in the construction of structurally unique and complex metabolites. This review discusses our current understanding of the functions and mechanisms of C-C bond forming radical SAM enzymes and highlights their important roles in the biosynthesis of structurally complex, naturally occurring organic molecules. Mechanistic consideration of C-C bond formation by radical SAM enzymes identifies the significance of three key mechanistic factors: radical initiation, acceptor substrate activation and radical quenching. Understanding the functions and mechanisms of these characteristic enzymes will be important not only in promoting our understanding of radical SAM enzymes, but also for understanding natural product and cofactor biosynthesis.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Satterlee, J.D.; Erman, J.E.; Mauro, J.M.

Proton NMR spectra of cytochrome c peroxidase (CcP) isolated from yeast (wild type) and two Escherichia coli expressed proteins, the parent expressed protein (CcP(MI)) and the site-directed mutant CcP(MI,D235N) (Asp-235 {yields} Asn-235), have been examined. At neutral pH and in the presence of only potassium phosphate buffer and potassium nitrate, wild-type Ccp and CcP(MI) demonstrate nearly identical spectra corresponding to normal (i.e., unaged) high-spin ferric peroxidase. In contrast, the mutant protein displays a spectrum characteristic of a low-spin form, probably a result of hydroxide ligation. Asp-235 is hydrogen-bonded to the proximal heme ligand, His-175. Changing Asp-235 to Asn results inmore » alteration of the pK for formation of the basic form of CcP. Thus, changes in proximal side structure mediate the chemistry of the distal ligand binding site. All three proteins bind F{sup {minus}}, N{sub 3}{sup {minus}}, and CN{sup {minus}} ions, although the affinity of the mutant protein (D235N) for fluoride ion appears to be much higher than that of the other two proteins. Analysis of proton NMR spectra of the cyanide ligated forms leads to the conclusion that the mutant protein (D235N) possesses a more neutral proximal histidine imidazole ring than does either wild-type CcP or CcP(MI). It confirms that an important feature of the cytochrome c peroxidase structure is at least partial, and probably full, imidazolate character for the proximal histidine (His-175).« less

Observation of Spontaneous C=C Bond Breaking in the Reaction between Atomic Boron and Ethylene in Solid Neon.

PubMed

Jian, Jiwen; Lin, Hailu; Luo, Mingbiao; Chen, Mohua; Zhou, Mingfei

2016-07-11

A ground-state boron atom inserts into the C=C bond of ethylene to spontaneously form the allene-like compound H2 CBCH2 on annealing in solid neon. This compound can further isomerize to the propyne-like HCBCH3 isomer under UV light excitation. The observation of this unique spontaneous C=C bond insertion reaction is consistent with theoretical predictions that the reaction is thermodynamically exothermic and kinetically facile. This work demonstrates that the stronger C=C bond, rather than the less inert C-H bond, can be broken to form organoboron species from the reaction of a boron atom with ethylene even at cryogenic temperatures. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Iterative reactions of transient boronic acids enable sequential C-C bond formation

NASA Astrophysics Data System (ADS)

Battilocchio, Claudio; Feist, Florian; Hafner, Andreas; Simon, Meike; Tran, Duc N.; Allwood, Daniel M.; Blakemore, David C.; Ley, Steven V.

2016-04-01

The ability to form multiple carbon-carbon bonds in a controlled sequence and thus rapidly build molecular complexity in an iterative fashion is an important goal in modern chemical synthesis. In recent times, transition-metal-catalysed coupling reactions have dominated in the development of C-C bond forming processes. A desire to reduce the reliance on precious metals and a need to obtain products with very low levels of metal impurities has brought a renewed focus on metal-free coupling processes. Here, we report the in situ preparation of reactive allylic and benzylic boronic acids, obtained by reacting flow-generated diazo compounds with boronic acids, and their application in controlled iterative C-C bond forming reactions is described. Thus far we have shown the formation of up to three C-C bonds in a sequence including the final trapping of a reactive boronic acid species with an aldehyde to generate a range of new chemical structures.

30 CFR 1218.560 - How do I submit Form ONRR-4444?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false How do I submit Form ONRR-4444? 1218.560... Service of Official Correspondence § 1218.560 How do I submit Form ONRR-4444? You may obtain a copy of Form ONRR-4444 and instructions from ONRR. This form is posted at http://www.onrr.gov/FM/Forms/default...

30 CFR 1218.560 - How do I submit Form ONRR-4444?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false How do I submit Form ONRR-4444? 1218.560... Service of Official Correspondence § 1218.560 How do I submit Form ONRR-4444? You may obtain a copy of Form ONRR-4444 and instructions from ONRR. This form is posted at http://www.onrr.gov/FM/Forms/default...

28 CFR 542.15 - Appeals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... response may submit an Appeal on the appropriate form (BP-10) to the appropriate Regional Director within... Regional Director's response may submit an Appeal on the appropriate form (BP-11) to the General Counsel... appeal. (b) Form. (1) Appeals to the Regional Director shall be submitted on the form designed for...

28 CFR 542.15 - Appeals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... response may submit an Appeal on the appropriate form (BP-10) to the appropriate Regional Director within... Regional Director's response may submit an Appeal on the appropriate form (BP-11) to the General Counsel... appeal. (b) Form. (1) Appeals to the Regional Director shall be submitted on the form designed for...

27 CFR 73.34 - When is an electronically submitted form considered timely filed?

Code of Federal Regulations, 2010 CFR

2010-04-01

... AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURES AND PRACTICES ELECTRONIC SIGNATURES; ELECTRONIC SUBMISSION OF FORMS Electronic Filing of Documents with TTB § 73.34 When is an electronically submitted form considered timely filed? If you submit a form to our electronic...

41 CFR 61-250.11 - On what form must the data required by this part be submitted?

Code of Federal Regulations, 2014 CFR

2014-07-01

... boxes. Type of Form: If a reporting organization submits only one VETS-100 Report form for a single location, check the Single Establishment box. If the reporting organization submits more than one form... the space provided. For each form, only one box should be checked within this block. COMPANY...

41 CFR 61-250.11 - On what form must the data required by this part be submitted?

Code of Federal Regulations, 2012 CFR

2012-07-01

... boxes. Type of Form: If a reporting organization submits only one VETS-100 Report form for a single location, check the Single Establishment box. If the reporting organization submits more than one form... the space provided. For each form, only one box should be checked within this block. COMPANY...

41 CFR 61-250.11 - On what form must the data required by this part be submitted?

Code of Federal Regulations, 2013 CFR

2013-07-01

... boxes. Type of Form: If a reporting organization submits only one VETS-100 Report form for a single location, check the Single Establishment box. If the reporting organization submits more than one form... the space provided. For each form, only one box should be checked within this block. COMPANY...

30 CFR 1210.201 - How do I submit Form ONRR-4430, Solid Minerals Production and Royalty Report?

Code of Federal Regulations, 2014 CFR

2014-07-01

... and submitting Form ONRR-4430 are available on our Internet reporting web site or you may contact us toll free at 1-888-201-6416. (b) When to submit. (1) Unless your lease terms specify a different... submit Form ONRR-4430 electronically using our Internet reporting web site unless you meet the conditions...

30 CFR 1210.201 - How do I submit Form ONRR-4430, Solid Minerals Production and Royalty Report?

Code of Federal Regulations, 2013 CFR

2013-07-01

... and submitting Form ONRR-4430 are available on our Internet reporting web site or you may contact us toll free at 1-888-201-6416. (b) When to submit. (1) Unless your lease terms specify a different... submit Form ONRR-4430 electronically using our Internet reporting web site unless you meet the conditions...

30 CFR 1218.560 - How do I submit Form MMS-4444?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false How do I submit Form MMS-4444? 1218.560 Section... Service of Official Correspondence § 1218.560 How do I submit Form MMS-4444? You may obtain a copy of Form MMS-4444 and instructions from ONRR. This form is posted at http://www.onrr.gov/FM/Forms/default.htm...

Enhanced mechanical properties of hydrothermal carbamated cellulose nanocomposite film reinforced with graphene oxide.

PubMed

Gan, Sinyee; Zakaria, Sarani; Syed Jaafar, Sharifah Nabihah

2017-09-15

Cellulose carbamate (CC) was synthesized via hydrothermal process and mixed with graphene oxide (GO) to form a homogeneous cellulose matrix nanocomposite films. The properties of CC/GO nanocomposite films fabricated using simple solution-mixing method with different GO loadings were studied. Transmission electron microscope analysis showed the exfoliation of self-synthesized GO nanosheets within the CC matrix. X-ray diffraction results confirmed the crystalline structure of CC/GO films as the CC/GO mass ratio increased from 100/0 to 100/4. The mechanical properties of CC/GO film were significantly improved as compared to neat CC film. From thermogravimetric analysis result, the introduction of GO enhanced the thermal stability and carbon yields. The 3D homogeneous porous structures of the CC/GO films were observed under Field emission scanning electron microscope. These improvements in nanocomposite film properties could be confirmed by Fourier transform infrared spectroscopy due to the strong and good interactions between CC and GO. Copyright © 2017 Elsevier Ltd. All rights reserved.

Cubanes: Super explosives and potential pharmaceutical intermediates

NASA Technical Reports Server (NTRS)

Bashir-Hashemi, A.

1994-01-01

The cubane molecule, in which eight carbon atoms are locked in a cubic framework, shows great potential for both military and pharmaceutical applications. Octanitrocubane, with a predicted density of 2.1 g/cc and strain energy of more than 165 kcal/mol, is considered to be the 'super-explosive', while cubane derivatives submitted to the National Institutes of Health for preliminary biological activity screening have displayed promising anti-cancer and anti-HIV activity.

40 CFR Appendix to Subpart Cc of... - Tables

Code of Federal Regulations, 2011 CFR

2011-07-01

... 150 days of the compliance dates”; except in §§ 63.182 (c)(2) and (c)(4). 63.182(d) Periodic report...)-63.1(c)(4) No Reserved. 63.1(c)(5) Yes Except that sources are not required to submit notifications...) Yes 63.4(a)(3)-63.4(a)(5) No Reserved. 63.4(b) Yes 63.4(c) Yes 63.5(a) Yes 63.5(b)(1) Yes 63.5(b)(2...

Alkali metal mediated C-C bond coupling reaction

NASA Astrophysics Data System (ADS)

Tachikawa, Hiroto

2015-02-01

Metal catalyzed carbon-carbon (C-C) bond formation is one of the important reactions in pharmacy and in organic chemistry. In the present study, the electron and hole capture dynamics of a lithium-benzene sandwich complex, expressed by Li(Bz)2, have been investigated by means of direct ab-initio molecular dynamics method. Following the electron capture of Li(Bz)2, the structure of [Li(Bz)2]- was drastically changed: Bz-Bz parallel form was rapidly fluctuated as a function of time, and a new C-C single bond was formed in the C1-C1' position of Bz-Bz interaction system. In the hole capture, the intermolecular vibration between Bz-Bz rings was only enhanced. The mechanism of C-C bond formation in the electron capture was discussed on the basis of theoretical results.

Addition by subtraction in coupled-cluster theory: a reconsideration of the CC and CI interface and the nCC hierarchy.

PubMed

Bartlett, Rodney J; Musiał, Monika

2006-11-28

The nCC hierarchy of coupled-cluster approximations, where n guarantees exactness for n electrons and all products of n electrons are derived and applied to several illustrative problems. The condition of exactness for n=2 defines nCCSD=2CC, with nCCSDT=3CC and nCCSDTQ=4CC being exact for three and four electrons. To achieve this, the minimum number of diagrams is evaluated, which is less than in the corresponding CC model. For all practical purposes, nCC is also the proper definition of a size-extensive CI. 2CC is also an orbitally invariant coupled electron pair approximation. The numerical results of nCC are close to those for the full CC variant, and in some cases are closer to the full CI reference result. As 2CC is exact for separated electron pairs, it is the natural zeroth-order approximation for the correlation problem in molecules with other effects introduced as these units start to interact. The nCC hierarchy of approximations has all the attractive features of CC including its size extensivity, orbital invariance, and orbital insensitivity, but in a conceptually appealing form suited to bond breaking, while being computationally less demanding. Excited states from the equation of motion (EOM-2CC) are also reported, which show results frequently approaching those of EOM-CCSDT.

30 CFR 1210.201 - How do I submit Form MMS-4430, Solid Minerals Production and Royalty Report?

Code of Federal Regulations, 2012 CFR

2012-07-01

... submitting Form MMS-4430 are available on our Internet reporting web site or you may contact us toll free at... submit Form MMS-4430 electronically using our Internet reporting web site unless you meet the conditions...

High density crystalline boron prepared by hot isostatic pressing in refractory metal containers

DOEpatents

Hoenig, C.L.

1993-08-31

Boron powder is hot isostatically pressed in a refractory metal container to produce a solid boron monolith with a bulk density at least 2.22 g/cc and up to or greater than 2.34 g/cc. The refractory metal container is formed of tantalum, niobium, tungsten, molybdenum or alloys thereof in the form of a canister or alternatively plasma sprayed or chemical vapor deposited onto a powder compact. Hot isostatic pressing at 1,800 C and 30 PSI (206.8 MPa) argon pressure for four hours produces a bulk density of 2.34 g/cc. Complex shapes can be made.

High density crystalline boron prepared by hot isostatic pressing in refractory metal containers

DOEpatents

Hoenig, Clarence L.

1993-01-01

Boron powder is hot isostatically pressed in a refractory metal container to produce a solid boron monolith with a bulk density at least 2.22 g/cc and up to or greater than 2.34 g/cc. The refractory metal container is formed of tantalum, niobium, tungsten, molybdenum or alloys thereof in the form of a canister or alternatively plasma sprayed or chemical vapor deposited onto a powder compact. Hot isostatic pressing at 1800.degree. C. and 30 KSI (206.8 MPa) argon pressure for four hours produces a bulk density of 2.34 g/cc. Complex shapes can be made.

78 FR 6150 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... required to submit reports of employee service and compensation to the RRB as needed for administering the... home addresses of all employees hired within the last year (new-hires). Form BA-6a, Form BA-6 Address.... The form also serves as an instruction sheet to railroad employers who can submit the information...

20 CFR 703.105 - Copies of forms of policies to be submitted with application.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Copies of forms of policies to be submitted... REGULATIONS Authorization of Insurance Carriers § 703.105 Copies of forms of policies to be submitted with... of the Office copies of the forms of policies which the applicant proposes to issue in writing...

Evaluating the Role of Writing in the First and Second Year University Foreign Language Curriculum

ERIC Educational Resources Information Center

Hubert, Michael D.

2014-01-01

Approaches to foreign language (FL) instruction have changed a great deal in the past fifty years, the most fundamental change being the shift from a focus solely on language form to a focus on communicative competence (CC). Although most FL instructors now appear to focus on CC in the teaching of speaking, they do not necessarily apply CC to…

Ectopic expression of the Coffea canephora SERK1 homolog-induced differential transcription of genes involved in auxin metabolism and in the developmental control of embryogenesis.

PubMed

Pérez-Pascual, Daniel; Jiménez-Guillen, Doribet; Villanueva-Alonzo, Hernán; Souza-Perera, Ramón; Godoy-Hernández, Gregorio; Zúñiga-Aguilar, José Juan

2018-04-01

Somatic embryogenesis receptor-like kinase 1 (SERK1) is a membrane receptor that might serve as common co-regulator of plant cell differentiation processes by forming heterodimers with specific receptor-like kinases. The Coffea canephora SERK1 homolog (CcSERK1) was cloned in this work, and its early function in the transcription of embryogenesis master genes and of genes encoding proteins involved in auxin metabolism was investigated by externally manipulating its expression in embryogenic leaf explants, before the appearance of embryogenic structures. Overexpression of CcSERK1 early during embryogenesis caused an increase in the number of somatic embryos when the 55-day process was completed. Suppression of CcSERK1 expression by RNA interference almost abolished somatic embryogenesis. Real time-PCR experiments revealed that the transcription of the CcAGL15, CcWUS, CcBBM, CcPKL, CcYUC1, CcPIN1 and CcPIN4 homologs was modified in direct proportion to the expression of CcSERK1 and that only CcLEC1 was inversely affected by the expression levels of CcSERK1. The expression of the CcYUC4 homolog was induced to more than 80-fold under CcSERK1 overexpression conditions, but it was also induced when CcSERK1 expression was silenced. The level of CcTIR1 was not affected by CcSERK1 overexpression but was almost abolished during CcSERK1 silencing. These results suggest that CcSERK1 co-regulates the induction of somatic embryogenesis in Coffea canephora by early activation of YUC-dependent auxin biosynthesis, auxin transport mediated by PIN1 and PIN4, and probably auxin perception by the TIR1 receptor, leading to the induction of early-stage homeotic genes (CcAGL15, CcWUS, CcPKL and CcBBM) and repression of late-stage homeotic genes (CcLec1). © 2018 Scandinavian Plant Physiology Society.

76 FR 71389 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-17

... techniques or other forms of information technology. Comments to the RRB or OIRA must contain the OMB control... equivalent version of Form BA-3 that can be submitted through the ERS which will include the option to file a.../System Access Application. OMB Control Number: 3220-0008. Forms Submitted: BA-3, BA-3 (Internet), BA-4...

78 FR 72139 - Forms Submitted to the Office of Management and Budget for Extension of Clearance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

... should be sent to the Office of Information and Regulatory Affairs, Attention: Desk Officer, Selective... SELECTIVE SERVICE SYSTEM Forms Submitted to the Office of Management and Budget for Extension of Clearance AGENCY: Selective Service System. ACTION: Notice. The following forms have been submitted to the...

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2011-11-15

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76 FR 62892 - Form Submitted to the Office of Management and Budget for Extension of Clearance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... should be sent to the Office of Information and Regulatory Affairs, Attention: Desk Officer, Selective... SELECTIVE SERVICE SYSTEM Form Submitted to the Office of Management and Budget for Extension of Clearance AGENCY: Selective Service System. ACTION: Notice. The following form has been submitted to the...

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2011-03-07

... SELECTIVE SERVICE SYSTEM Form Submitted to the Office of Management and Budget for Extension of Clearance AGENCY: Selective Service System. ACTION: Notice. The following form has been submitted to the... boards in the Selective Service System. Respondents: Potential board members. Burden: A burden of 15...

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Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... Regulatory Affairs, Attention: Desk Officer, Selective Service System, Office of Management and Budget, New... SELECTIVE SERVICE SYSTEM Form Submitted to the Office of Management and Budget for Extension of Clearance AGENCY: Selective Service System. ACTION: Notice. The following form has been submitted to the...

76 FR 41855 - Forms Submitted to the Office of Management and Budget for Extension of Clearance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-15

... Regulatory Affairs, Attention: Desk Officer, Selective Service System, Office of Management and Budget, New... SELECTIVE SERVICE SYSTEM Forms Submitted to the Office of Management and Budget for Extension of Clearance AGENCY: Selective Service System. ACTION: Notice. The following form has been submitted to the...

Cartilage conduction is characterized by vibrations of the cartilaginous portion of the ear canal.

PubMed

Nishimura, Tadashi; Hosoi, Hiroshi; Saito, Osamu; Miyamae, Ryosuke; Shimokura, Ryota; Yamanaka, Toshiaki; Kitahara, Tadashi; Levitt, Harry

2015-01-01

Cartilage conduction (CC) is a new form of sound transmission which is induced by a transducer being placed on the aural cartilage. Although the conventional forms of sound transmission to the cochlea are classified into air or bone conduction (AC or BC), previous study demonstrates that CC is not classified into AC or BC (Laryngoscope 124: 1214-1219). Next interesting issue is whether CC is a hybrid of AC and BC. Seven volunteers with normal hearing participated in this experiment. The threshold-shifts by water injection in the ear canal were measured. AC, BC, and CC thresholds at 0.5-4 kHz were measured in the 0%-, 40%-, and 80%-water injection conditions. In addition, CC thresholds were also measured for the 20%-, 60%-, 100%-, and overflowing-water injection conditions. The contributions of the vibrations of the cartilaginous portion were evaluated by the threshold-shifts. For AC and BC, the threshold-shifts by the water injection were 22.6-53.3 dB and within 14.9 dB at the frequency of 0.5-4 kHz, respectively. For CC, when the water was filled within the bony portion, the thresholds were elevated to the same degree as AC. When the water was additionally injected to reach the cartilaginous portion, the thresholds at 0.5 and 1 kHz dramatically decreased by 27.4 and 27.5 dB, respectively. In addition, despite blocking AC by the injected water, the CC thresholds in force level were remarkably lower than those for BC. The vibration of the cartilaginous portion contributes to the sound transmission, particularly in the low frequency range. Although the airborne sound is radiated into the ear canal in both BC and CC, the mechanism underlying its generation is different between them. CC generates airborne sound in the canal more efficiently than BC. The current findings suggest that CC is not a hybrid of AC and BC.

Cartilage Conduction Is Characterized by Vibrations of the Cartilaginous Portion of the Ear Canal

PubMed Central

Nishimura, Tadashi; Hosoi, Hiroshi; Saito, Osamu; Miyamae, Ryosuke; Shimokura, Ryota; Yamanaka, Toshiaki; Kitahara, Tadashi; Levitt, Harry

2015-01-01

Cartilage conduction (CC) is a new form of sound transmission which is induced by a transducer being placed on the aural cartilage. Although the conventional forms of sound transmission to the cochlea are classified into air or bone conduction (AC or BC), previous study demonstrates that CC is not classified into AC or BC (Laryngoscope 124: 1214–1219). Next interesting issue is whether CC is a hybrid of AC and BC. Seven volunteers with normal hearing participated in this experiment. The threshold-shifts by water injection in the ear canal were measured. AC, BC, and CC thresholds at 0.5–4 kHz were measured in the 0%-, 40%-, and 80%-water injection conditions. In addition, CC thresholds were also measured for the 20%-, 60%-, 100%-, and overflowing-water injection conditions. The contributions of the vibrations of the cartilaginous portion were evaluated by the threshold-shifts. For AC and BC, the threshold-shifts by the water injection were 22.6–53.3 dB and within 14.9 dB at the frequency of 0.5–4 kHz, respectively. For CC, when the water was filled within the bony portion, the thresholds were elevated to the same degree as AC. When the water was additionally injected to reach the cartilaginous portion, the thresholds at 0.5 and 1 kHz dramatically decreased by 27.4 and 27.5 dB, respectively. In addition, despite blocking AC by the injected water, the CC thresholds in force level were remarkably lower than those for BC. The vibration of the cartilaginous portion contributes to the sound transmission, particularly in the low frequency range. Although the airborne sound is radiated into the ear canal in both BC and CC, the mechanism underlying its generation is different between them. CC generates airborne sound in the canal more efficiently than BC. The current findings suggest that CC is not a hybrid of AC and BC. PMID:25768088

Are adolescents with chronic conditions particularly at risk for bullying?

PubMed

Pittet, I; Berchtold, A; Akré, C; Michaud, P-A; Surís, J-C

2010-09-01

To compare the prevalence and intensity of victimisation from bullying and the characteristics of the victim of bullying, comparing adolescents with and adolescents without chronic conditions (CC). School survey. Postmandatory schools. A total of 7005 students (48% females) aged 16-20 years, distributed into adolescents with CC (728, 50% females) and controls (6277, 48% females). Chronic condition was defined as having a chronic disease and/or a physical disability. Prevalence of bullying-intensity of bullying-and sociodemographic, biopsychosocial, familial, school and violence context characteristics of the victims of bullying. The prevalence of bullying in our sample was 13.85%. Adolescents with CC were more likely to be victims of bullying (adjusted OR 1.53), and to be victims of two or three forms of bullying (adjusted OR 1.92). Victims of bullying with CC were more likely than non-victims to be depressed (RR 1.57), to have more physical symptoms (RR 1.61), to have a poorer relationship with their parents (RR 1.33), to have a poorer school climate (RR 1.60) and to have been victims of sexual abuse (RR 1.79) or other forms of violence (RR 1.80). Although these characteristics apply to victims in general, in most cases, they are less pronounced among victims without CC. CC seems to be a risk factor for victimisation from bullying. Therefore, as adolescents with CC are increasingly mainstreamed, schools should be encouraged to undertake preventive measures to avoid victimisation of such adolescents.

43 CFR 428.4 - Who must submit forms under this part.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Who must submit forms under this part. 428.4 Section 428.4 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION... THE ELIGIBILITY OF CERTAIN FORMERLY EXCESS LAND § 428.4 Who must submit forms under this part. (a) You...

Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice.

PubMed

Braunersreuther, Vincent; Montecucco, Fabrizio; Pelli, Graziano; Galan, Katia; Proudfoot, Amanda E; Belin, Alexandre; Vuilleumier, Nicolas; Burger, Fabienne; Lenglet, Sébastien; Caffa, Irene; Soncini, Debora; Nencioni, Alessio; Vallée, Jean-Paul; Mach, François

2013-10-01

Chemokines trigger leukocyte trafficking and are implicated in cardiovascular disease pathophysiology. Chemokine-binding proteins, called "Evasins" have been shown to inhibit both CC and CXC chemokine-mediated bioactivities. Here, we investigated whether treatment with Evasin-3 (CXC chemokine inhibitor) and Evasin-4 (CC chemokine inhibitor) could influence post-infarction myocardial injury and remodelling. C57Bl/6 mice were submitted in vivo to left coronary artery permanent ligature and followed up for different times (up to 21 days). After coronary occlusion, three intraperitoneal injections of 10 μg Evasin-3, 1 μg Evasin-4 or equal volume of vehicle (PBS) were performed at 5 minutes, 24 hours (h) and 48 h after ischaemia onset. Both anti-chemokine treatments were associated with the beneficial reduction in infarct size as compared to controls. This effect was accompanied by a decrease in post-infarction myocardial leukocyte infiltration, reactive oxygen species release, and circulating levels of CXCL1 and CCL2. Treatment with Evasin-4 induced a more potent effect, abrogating the inflammation already at one day after ischaemia onset. At days 1 and 21 after ischaemia onset, both anti-chemokine treatments failed to significantly improve cardiac function, remodelling and scar formation. At 21-day follow-up, mouse survival was exclusively improved by Evasin-4 treatment when compared to control vehicle. In conclusion, we showed that the selective inhibition of CC chemokines (i.e. CCL5) with Evasin-4 reduced cardiac injury/inflammation and improved survival. Despite the inhibition of CXC chemokine bioactivities, Evasin-3 did not affect mouse survival. Therefore, early inhibition of CC chemokines might represent a promising therapeutic approach to reduce the development of post-infarction heart failure in mice.

An Expert System for Searching in Full-Text

DTIC Science & Technology

1989-12-01

2 An Expert System for Searching in Full-Text 00~ TR89-043 -December, 1989 cc D IF L, ~r." T M~ EA 13~ 1991ON- The University of North Carolina at...Full-Text by Susan Evalyn Gauch A dissertation submitted to the faculty of The University of North Carolina at Chapel Hill in partial fulfillment of...MICROARRAS, the retrieval software. MICROARRAS developed at the University of North Carolina under the direction of John B. Smith and Stephen Weiss [Smith et

40 CFR 60.2795 - In what form can I submit my reports?

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CDX) by using the Electronic Reporting Tool (ERT) (see http://www.epa.gov/ttn/chief/ert/ert_tool.html). ... Reporting § 60.2795 In what form can I submit my reports? Submit initial, annual, and deviation reports...

76 FR 67729 - Information Collection Being Submitted for Review and Approval to the Office of Management and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-02

... operators submit this form to local franchising authorities or the Commission, in situations where the FCC... changes in external costs. Cable operators submit FCC Form 1240 to their respective local franchising...

Open Source Subtitle Editor Software Study for Section 508 Close Caption Applications

NASA Technical Reports Server (NTRS)

Murphy, F. Brandon

2013-01-01

This paper will focus on a specific item within the NASA Electronic Information Accessibility Policy - Multimedia Presentation shall have synchronized caption; thus making information accessible to a person with hearing impairment. This synchronized caption will assist a person with hearing or cognitive disability to access the same information as everyone else. This paper focuses on the research and implementation for CC (subtitle option) support to video multimedia. The goal of this research is identify the best available open-source (free) software to achieve synchronized captions requirement and achieve savings, while meeting the security requirement for Government information integrity and assurance. CC and subtitling are processes that display text within a video to provide additional or interpretive information for those whom may need it or those whom chose it. Closed captions typically show the transcription of the audio portion of a program (video) as it occurs (either verbatim or in its edited form), sometimes including non-speech elements (such as sound effects). The transcript can be provided by a third party source or can be extracted word for word from the video. This feature can be made available for videos in two forms: either Soft-Coded or Hard-Coded. Soft-Coded is the more optional version of CC, where you can chose to turn them on if you want, or you can turn them off. Most of the time, when using the Soft-Coded option, the transcript is also provided to the view along-side the video. This option is subject to compromise, whereas the transcript is merely a text file that can be changed by anyone who has access to it. With this option the integrity of the CC is at the mercy of the user. Hard-Coded CC is a more permanent form of CC. A Hard-Coded CC transcript is embedded within a video, without the option of removal.

High Incidence of Pathogenic Streptococcus agalactiae ST485 Strain in Pregnant/Puerperal Women and Isolation of Hyper-Virulent Human CC67 Strain

PubMed Central

Li, Liping; Wang, Rui; Huang, Yan; Huang, Ting; Luo, Fuguang; Huang, Weiyi; Yang, Xiuying; Lei, Aiying; Chen, Ming; Gan, Xi

2018-01-01

Group B streptococcus (GBS) is the major pathogen causing diseases in neonates, pregnant/puerperal women, cows and fish. Recent studies have shown that GBS may be infectious across hosts and some fish GBS strain might originate from human. The purpose of this study is to investigate the genetic relationship of CC103 strains that recently emerged in cows and humans, and explore the pathogenicity of clinical GBS isolates from human to tilapia. Ninety-two pathogenic GBS isolates were identified from 19 patients with different diseases and their evolution and pathogenicity to tilapia were analyzed. The multilocus sequence typing revealed that clonal complex (CC) 103 strain was isolated from 21.74% (20/92) of patients and ST485 strain was from 14.13% (13/92) patients with multiple diseases including neonates. Genomic evolution analysis showed that both bovine and human CC103 strains alternately form independent evolutionary branches. Three CC67 isolates carried gbs2018-C gene and formed one evolutionary branch with ST61 and ST67 strains that specifically infect dairy cows. Studies of interspecies transmission to tilapia found that 21/92 (22.83%) isolates including all ST23 isolates were highly pathogenic to tilapia and demonstrated that streptococci could break through the blood-brain barrier into brain tissue. In conclusions, CC103 strains are highly prevalent among pathogenic GBS from humans and have evolved into the highly pathogenic ST485 strains specifically infecting humans. The CC67 strains isolated from cows are able to infect humans through evolutionary events of acquiring CC17-specific type C gbs2018 gene and others. Human-derived ST23 pathogenic GBS strains are highly pathogenic to tilapia. PMID:29467722

Hyaluronan and calcium carbonate hybrid nanoparticles for colorectal cancer chemotherapy

NASA Astrophysics Data System (ADS)

Bai, Jinghui; Xu, Jian; Zhao, Jian; Zhang, Rui

2017-09-01

A hybrid drug delivery system (DDS) composed of hyaluronan and calcium carbonate (CC) was developed. By taking advantage of the tumor-targeting ability of hyaluronan and the drug-loading property of CC, the well-formed hyaluronan-CC nanoparticles were able to serve as a DDS targeting colorectal cancer with a decent drug loading content, which is beneficial in the chemotherapy of colorectal cancer. In this study, hyaluronan-CC nanoparticles smaller than 100 nm were successfully developed to load the wide-range anti-cancer drug adriamycin (Adr) to construct hyaluronan-CC/Adr nanoparticles. On the other hand, we also found that hyaluronan-CC/Adr nanoparticles can possibly increase the uptake ratio of Adr into HT29 colorectal cancer cells when compared with hyaluronan-free nanoparticles (CC/Adr) via the CD44 receptor-mediated endocytosis via competitive uptake and in vivo imaging assays. Note that both in vitro (CCK-8 assay on HT29 cells) and in vivo (anti-cancer assay on HT-29 tumor-bearing nude mice model) experiments revealed that hyaluronan-CC/Adr nanoparticles exhibited stronger anti-cancer activity than free Adr or CC/Adr nanoparticles with minimized toxic side effects and preferable cancer-suppression potential.

Arbuscular mycorrhizal fungi improve photosynthetic energy use efficiency and decrease foliar construction cost under recurrent water deficit in woody evergreen species.

PubMed

Barros, Vanessa; Frosi, Gabriella; Santos, Mariana; Ramos, Diego Gomes; Falcão, Hiram Marinho; Santos, Mauro Guida

2018-06-01

Plants suffer recurrent cycles of water deficit in semiarid regions and have several mechanisms to tolerate low water availability. Thus, arbuscular mycorrhizal fungi (AMF) can alleviate deleterious effects of stress. In this study, Cynophalla flexuosa plants, a woody evergreen species from semiarid, when associated with AMF were exposed to two consecutive cycles of water deficit. Leaf primary metabolism, specific leaf area (SLA), leaf construction cost (CC) and photosynthetic energy use efficiency (PEUE) were measured. The maximum stress occurred on seven days (cycle 1) and ten days (cycle 2) after suspending irrigation (photosynthesis close to zero). The rehydration was performed for three days after each maximum stress. In both cycles, plants submitted to water deficit showed reduced gas exchange and leaf relative water content. However, Drought + AMF plants had significantly larger leaf relative water content in cycle 2. At cycle 1, the SLA was larger in non-inoculated plants, while CC was higher in inoculated plants. At cycle 2, Drought + AMF treatment had lower CC and large SLA compared to control, and high PEUE compared to Drought plants. These responses suggest AMFs increase tolerance of C. flexuosa to recurrent water deficit, mainly in cycle 2, reducing the CC, promoting the improvement of SLA and PEUE, leading to higher photosynthetic area. Thus, our result emphasizes the importance of studies on recurrence of water deficit, a common condition in semiarid environments. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Ursodeoxycholic acid impairs atherogenesis and promotes plaque regression by cholesterol crystal dissolution in mice.

PubMed

Bode, Niklas; Grebe, Alena; Kerksiek, Anja; Lütjohann, Dieter; Werner, Nikos; Nickenig, Georg; Latz, Eicke; Zimmer, Sebastian

2016-09-09

Atherosclerosis is a chronic inflammatory disease driven primarily by a continuous retention of cholesterol within the subendothelial space where it precipitates to form cholesterol crystals (CC). These CC trigger a complex inflammatory response through activation of the NLRP3 inflammasome and promote lesion development. Here we examined whether increasing cholesterol solubility with ursodeoxycholic acid (UDCA) affects vascular CC formation and ultimately atherosclerotic lesion development. UDCA mediated intracellular CC dissolution in macrophages and reduced IL-1β production. In ApoE(-/-) mice, UDCA treatment not only impaired atherosclerotic plaque development but also mediated regression of established vascular lesions. Importantly, mice treated with UDCA had decreased CC-depositions in atherosclerotic plaques compared to controls. Together, our data demonstrate that UDCA impaired CC and NLRP3 dependent inflammation by increasing cholesterol solubility and diminished atherosclerosis in mice. Copyright © 2016 Elsevier Inc. All rights reserved.

Evolution of interstellar organic compounds under asteroidal hydrothermal conditions

NASA Astrophysics Data System (ADS)

Vinogradoff, V.; Bernard, S.; Le Guillou, C.; Remusat, L.

2018-05-01

Carbonaceous chondrites (CC) contain a diversity of organic compounds. No definitive evidence for a genetic relationship between these complex organic molecules and the simple organic molecules detected in the interstellar medium (ISM) has yet been reported. One of the many difficulties arises from the transformations of organic compounds during accretion and hydrothermal alteration on asteroids. Here, we report results of hydrothermal alteration experiments conducted on a common constituent of interstellar ice analogs, Hexamethylenetetramine (HMT - C6H12N4). We submitted HMT to asteroidal hydrothermal conditions at 150 °C, for various durations (up to 31 days) and under alkaline pH. Organic products were characterized by gas chromatography mass spectrometry, infrared spectroscopy and synchrotron-based X-ray absorption near edge structure spectroscopy. Results show that, within a few days, HMT has evolved into (1) a very diverse suite of soluble compounds dominated by N-bearing aromatic compounds (> 150 species after 31 days), including for instance formamide, pyridine, pyrrole and their polymers (2) an aromatic and N-rich insoluble material that forms after only 7 days of experiment and then remains stable through time. The reaction pathways leading to the soluble compounds likely include HMT dissociation, formose and Maillard-type reactions, e.g. reactions of sugar derivatives with amines. The present study demonstrates that, if interstellar organic compounds such as HMT had been accreted by chondrite parent bodies, they would have undergone chemical transformations during hydrothermal alteration, potentially leading to the formation of high molecular weight insoluble organic molecules. Some of the diversity of soluble and insoluble organic compounds found in CC may thus result from asteroidal hydrothermal alteration.

Stage II Chronic Maxillary Atelectasis Associated with Subclinical Visual Field Defect.

PubMed

Mangussi-Gomes, João; Nakanishi, Márcio; Chalita, Maria Regina; Damasco, Fabiana; De Oliveira, Carlos Augusto Costa Pires

2013-10-01

Introduction Chronic maxillary atelectasis (CMA) is characterized by a persistent decrease in the maxillary sinus volume due to inward bowing of its walls. According to its severity, it may be classified into three clinical-radiological stages. Objective To report a case of stage II CMA associated with subclinical visual field defect. Case Report A 34-year-old woman presented with a 15-year history of recurrent episodes of sinusitis and intermittent right facial discomfort for the past 5 years. She denied visual complaints, and no facial deformities were observed on physical examination. Paranasal sinus computed tomography (CT) demonstrated a completely opacified right maxillary sinus with inward bowing of its walls, suggesting the diagnosis of stage II CMA. A computerized campimetry (CC) disclosed a scotoma adjacent to the blind spot of the right eye, indicating a possible damage to the optic nerve. The patient was submitted to functional endoscopic sinus surgery, with drainage of a thick mucous fluid from the sinus. She did well after surgery and has been asymptomatic since then. Postoperative CT was satisfactory and CC was normal. Discussion CMA occurs because of a persistent ostiomeatal obstruction, which creates negative pressure inside the sinus. It is associated with nasosinusal symptoms but had never been described in association with any visual field defect. It can be divided into stage I (membranous deformity), stage II (bony deformity), and stage III (clinical deformity). The silent sinus syndrome is a special form of CMA. This term should only be used to describe those cases with spontaneous enophthalmos, hypoglobus, and/or midfacial deformity in the absence of nasosinusal symptoms.

Hydrogen peroxide clusters: the role of open book motif in cage and helical structures.

PubMed

Elango, M; Parthasarathi, R; Subramanian, V; Ramachandran, C N; Sathyamurthy, N

2006-05-18

Hartree-Fock (HF) calculations using 6-31G*, 6-311++G(d,p), aug-cc-pVDZ, and aug-cc-pVTZ basis sets show that hydrogen peroxide molecular clusters tend to form hydrogen-bonded cyclic and cage structures along the lines expected of a molecule which can act as a proton donor as well as an acceptor. These results are reiterated by density functional theoretic (DFT) calculations with B3LYP parametrization and also by second-order Møller-Plesset perturbation (MP2) theory using 6-31G* and 6-311++G(d,p) basis sets. Trends in stabilization energies and geometrical parameters obtained at the HF level using 6-311++G(d,p), aug-cc-pVDZ, and aug-cc-pVTZ basis sets are similar to those obtained from HF/6-31G* calculation. In addition, the HF calculations suggest the formation of stable helical structures for larger clusters, provided the neighbors form an open book structure.

Sample Premanufacture Notification (PMN) Form

EPA Pesticide Factsheets

For users who need to submit a Premanufacture notice for new chemical substances, this document provides and example form. This form is not for submission, but it will help you figure out how to model your own form to submit to the agency.

75 FR 33806 - Proposed Agency Information Collection Activities; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... with Regulation CC (Expedited Funds Availability Act (EFAA)). Agency form number: Reg CC. OMB control... response: Banks: Specific availability policy disclosure and initial disclosures, 1 minute; notice in... consumer deposits, 15 minutes; annual notice of new automated teller machines (ATMs), 5 hours; ATM changes...

CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4.

PubMed

Deshar, Rakesh; Cho, Eun-Bee; Yoon, Sungjoo Kim; Yoon, Jong-Bok

2016-11-11

Signaling through many transmembrane receptors is terminated by their sorting to the intraluminal vesicles (ILVs) of multivescular bodies (MVBs) and subsequent lysosomal degradation. ILV formation requires the endosomal sorting complex required for transport (ESCRT) machinery. CC2D1A and CC2D1B interact with the CHMP4 family of proteins, the major subunit of the ESCRT-III complex, however, their roles in receptor degradation and signaling are poorly defined. Here, we report that CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway. We show that depletion of CC2D1A and B accelerates degradation of EGFR and elicits rapid termination of its downstream signaling through ERK1 and 2. Depletion of CC2D1A and B promotes sorting of EGFR to ILV leading to its rapid lysosomal degradation. In addition, we show that knockdown of CC2D1A and B has similar effects on degradation and downstream signaling of another membrane receptor, TLR4. Thus, these findings suggest that CC2D1A and B may have broad effects on transmembrane receptors by preventing premature ILV sorting and termination of signaling. Copyright © 2016 Elsevier Inc. All rights reserved.

Naval Reserve Annual Operating Costs

DTIC Science & Technology

1975-10-29

LUV WL mw f-U>) C V) L0 1-LUW (Y) CO Co LU C ::N co~- 00 L 0j C-L ) r-4 ) LL L C) LU -4 L- i ~~llC CJ> . C~ - f-J F. F-~fl0 LU WF- .- -( L-F- Q. C...0 Uj t&P NI I )P 0V’ 000 M N M ) 41 o - - 5.. t c I ., oe. P r oi 5.,. 005 CC CC f-N - 0I r 0c c0 N5 Oil j C co a0 OCY .Cw CC a~ r0 0 0 C5 n I CC CC tSC...34 i - L u- - l ____l______o____ REPORT DOCUMENTAl ION PAGE BEFORE MPLETI FORM I REPORT NUMBER 2. GOVY ACCESS|ON NO, 3. RECIPIENT’S CATALOG NUMBER 4

Giant Cornu Cutaneum Superimposed on Basal Cell Carcinoma.

PubMed

Agirgol, S; Mansur, A T; Bozkurt, K; Azakli, H N; Babacan, A; Dikmen, A

2015-09-01

Cornu cutaneum (CC) is a clinical term that describes the horn-like keratotic lesions extending vertically from the skin. Benign, premalignant or malignant lesions may be present at the base of CC. Seborrhoeic keratosis and squamous cell carcinoma (SCC) are the most commonly reported benign and malignant forms, respectively. Basal cell carcinoma (BCC) at the base is rare. Here, we report on an 85-year old female patient having multiple CC lesions, one being giant on her face and two of the lesions diagnosed with BCC at the base. This case is of significance due to the presence of giant and multiple CC and detection of BCC at the base of more than one lesion. This present case indicates the need for the treatment of possible malignant lesions underlying CC in the elderly by total surgical excision.

Study of pyrolysed acid and based treated coconut coir as green photocatalyst substrate

NASA Astrophysics Data System (ADS)

Asim, Nilofar; Emdadi, Zeynab; Abdullah, N. A.; Mohammad, Masita; Badiei, Marzieh; Sopian, Kamaruzzaman

2017-12-01

This study investigates the possible contribution to sustainable development by utilizing agriculture waste materials to prepare a substrate for photo-catalysis application. The photocatalytic performance of impregnated TiO2 on acid and base- treated coconut coir (CC) and their pyrolysed form have been studied. The photocatalytic performance of impregnated TiO2 on acid treated CC improved compared to bare TiO2. However, the pyrolysed samples showed higher thermal stability and porosity compared to only treated CC, their catalytic performance was decreased. It seems that impregnated TiO2 undergo interaction with treated CC during pyrolysis. More investigations to reveal exact reason of this behavior is in progress.

40 CFR 60.2235 - In what form can I submit my reports?

Code of Federal Regulations, 2012 CFR

2012-07-01

... opacity data, electronically to EPA's Central Data Exchange (CDX) by using the Electronic Reporting Tool (ERT) (see http://www.epa.gov/ttn/chief/ert/ert tool.html/) or other compatible electronic spreadsheet... Recordkeeping and Reporting § 60.2235 In what form can I submit my reports? Submit initial, annual, and...

40 CFR 60.2235 - In what form can I submit my reports?

Code of Federal Regulations, 2011 CFR

2011-07-01

... opacity data, electronically to EPA's Central Data Exchange (CDX) by using the Electronic Reporting Tool (ERT) (see http://www.epa.gov/ttn/chief/ert/ert tool.html/) or other compatible electronic spreadsheet... Recordkeeping and Reporting § 60.2235 In what form can I submit my reports? Submit initial, annual, and...

Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering

PubMed Central

Sandberg, Anders; Luheshi, Leila M.; Söllvander, Sofia; Pereira de Barros, Teresa; Macao, Bertil; Knowles, Tuomas P. J.; Biverstål, Henrik; Lendel, Christofer; Ekholm-Petterson, Frida; Dubnovitsky, Anatoly; Lannfelt, Lars; Dobson, Christopher M.; Härd, Torleif

2010-01-01

Soluble oligomeric aggregates of the amyloid-β peptide (Aβ) have been implicated in the pathogenesis of Alzheimer’s disease (AD). Although the conformation adopted by Aβ within these aggregates is not known, a β-hairpin conformation is known to be accessible to monomeric Aβ. Here we show that this β-hairpin is a building block of toxic Aβ oligomers by engineering a double-cysteine mutant (called Aβcc) in which the β-hairpin is stabilized by an intramolecular disulfide bond. Aβ40cc and Aβ42cc both spontaneously form stable oligomeric species with distinct molecular weights and secondary-structure content, but both are unable to convert into amyloid fibrils. Biochemical and biophysical experiments and assays with conformation-specific antibodies used to detect Aβ aggregates in vivo indicate that the wild-type oligomer structure is preserved and stabilized in Aβcc oligomers. Stable oligomers are expected to become highly toxic and, accordingly, we find that β-sheet-containing Aβ42cc oligomers or protofibrillar species formed by these oligomers are 50 times more potent inducers of neuronal apoptosis than amyloid fibrils or samples of monomeric wild-type Aβ42, in which toxic aggregates are only transiently formed. The possibility of obtaining completely stable and physiologically relevant neurotoxic Aβ oligomer preparations will facilitate studies of their structure and role in the pathogenesis of AD. For example, here we show how kinetic partitioning into different aggregation pathways can explain why Aβ42 is more toxic than the shorter Aβ40, and why certain inherited mutations are linked to protofibril formation and early-onset AD. PMID:20713699

High density-high purity graphite prepared by hot isostatic pressing in refractory metal containers

DOEpatents

Hoenig, Clarence L.

1994-01-01

Porous graphite in solid form is hot isostatically pressed in a refractory metal container to produce a solid graphite monolith with a bulk density greater than or equal to 2.10 g/cc. The refractory metal container is formed of tantalum, niobium, tungsten, molybdenum or alloys thereof in the form of a canister or alternatively plasma sprayed, chemically vapor deposited, or coated by some other suitable means onto graphite. Hot isostatic pressing at 2200.degree. C. and 30 KSI (206.8 MPa) argon pressure for two hours produces a bulk density of 2.10 g/cc. Complex shapes can be made.

High density-high purity graphite prepared by hot isostatic pressing in refractory metal containers

DOEpatents

Hoenig, C.L.

1994-08-09

Porous graphite in solid form is hot isostatically pressed in a refractory metal container to produce a solid graphite monolith with a bulk density greater than or equal to 2.10 g/cc. The refractory metal container is formed of tantalum, niobium, tungsten, molybdenum or alloys thereof in the form of a canister or alternatively plasma sprayed, chemically vapor deposited, or coated by some other suitable means onto graphite. Hot isostatic pressing at 2,200 C and 30 KSI (206.8 MPa) argon pressure for two hours produces a bulk density of 2.10 g/cc. Complex shapes can be made. 1 fig.

75 FR 54354 - Notice of Proposed Information Collection for Public Comment Allocation of Operating Subsidies...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-07

... submission. For Fiscal Year 2011, the Department is changing its submission methods for the subject forms... 52722 will be submitted through templates; form HUD 53087 will be submitted via hard copy. Agency Form...

18 CFR 35.13 - Filing of changes in rate schedules, tariffs or service agreements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... be reconciled with the utility's most recent FERC Form 1. If the utility has not yet submitted Form 1 for the Test Period, the utility shall submit the relevant Form 1 pages in draft form. (D) The utility.... Balance sheets shall be constructed in accordance with the annual report form for electric utilities...

18 CFR 35.13 - Filing of changes in rate schedules, tariffs or service agreements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... be reconciled with the utility's most recent FERC Form 1. If the utility has not yet submitted Form 1 for the Test Period, the utility shall submit the relevant Form 1 pages in draft form. (D) The utility.... Balance sheets shall be constructed in accordance with the annual report form for electric utilities...

18 CFR 35.13 - Filing of changes in rate schedules, tariffs or service agreements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... be reconciled with the utility's most recent FERC Form 1. If the utility has not yet submitted Form 1 for the Test Period, the utility shall submit the relevant Form 1 pages in draft form. (D) The utility.... Balance sheets shall be constructed in accordance with the annual report form for electric utilities...

18 CFR 35.13 - Filing of changes in rate schedules, tariffs or service agreements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... be reconciled with the utility's most recent FERC Form 1. If the utility has not yet submitted Form 1 for the Test Period, the utility shall submit the relevant Form 1 pages in draft form. (D) The utility.... Balance sheets shall be constructed in accordance with the annual report form for electric utilities...

18 CFR 35.13 - Filing of changes in rate schedules, tariffs or service agreements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... be reconciled with the utility's most recent FERC Form 1. If the utility has not yet submitted Form 1 for the Test Period, the utility shall submit the relevant Form 1 pages in draft form. (D) The utility.... Balance sheets shall be constructed in accordance with the annual report form for electric utilities...

77 FR 3289 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-23

... uses Form AA-6, Employee Application for Medicare; Form AA-7, Spouse/Divorced Spouse Application for Medicare; and Form AA-8, Widow/Widower Application for Medicare; to obtain the information needed to.... Forms submitted: AA-6, AA-7, AA-8, RL-311-F. Type of request: Extension without change of a currently...

Department of the Navy FY 1994 Budget Estimates. Military Personnel, Navy. Justification of Estimates Submitted to Congress April 1993

DTIC Science & Technology

1993-04-01

Co -ag a 9LiC o 4 L ma o ~ %an -cc 4nm a- .& el 1 ’AU) -j mat ma -- C2~. q.ýIL1g 9L maa-. 0 IFm ma cn "ij 4A ~ ~ ~ ~ ~ ~ ~ ~ r.. It C m;R .4IOa iec...am E n E n a- I E n C a g enS at ao on ~ 1 4a -w ;=- Lu -s I. LIMEn Lu d4 V. a a U a - aMC igS re aa- a-m n En - El In cc Ena LM am IL. l-S kCa En...In I! N.! cIn (𔃺) n (0 a CD 0 IInl 0C el -i ca af. Ca’. C-)rJ 1 . a" r- a ý i an a’ I- a a* * aina - S~ ~~~ In ~ I’ N. - U I n InnI al f I’f InI- 5

26 CFR 1.9101-1 - Permission to submit information required by certain returns and statements on magnetic tape.

Code of Federal Regulations, 2014 CFR

2014-04-01

... satisfied by submitting the information required by such form on magnetic tape or by other media, provided... submitting the information required by such form on magnetic tape or other approved media, provided that the prior consent of the Commissioner of Social Security (or other authorized officer or employee thereof...

26 CFR 1.9101-1 - Permission to submit information required by certain returns and statements on magnetic tape.

Code of Federal Regulations, 2013 CFR

2013-04-01

... satisfied by submitting the information required by such form on magnetic tape or by other media, provided... submitting the information required by such form on magnetic tape or other approved media, provided that the prior consent of the Commissioner of Social Security (or other authorized officer or employee thereof...

26 CFR 1.9101-1 - Permission to submit information required by certain returns and statements on magnetic tape.

Code of Federal Regulations, 2011 CFR

2011-04-01

... satisfied by submitting the information required by such form on magnetic tape or by other media, provided... submitting the information required by such form on magnetic tape or other approved media, provided that the prior consent of the Commissioner of Social Security (or other authorized officer or employee thereof...

26 CFR 1.9101-1 - Permission to submit information required by certain returns and statements on magnetic tape.

Code of Federal Regulations, 2012 CFR

2012-04-01

... satisfied by submitting the information required by such form on magnetic tape or by other media, provided... submitting the information required by such form on magnetic tape or other approved media, provided that the prior consent of the Commissioner of Social Security (or other authorized officer or employee thereof...

30 CFR 1206.458 - Determination of washing allowances.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., before any deduction may be taken, the lessee must submit a completed page one of Form MMS-4292, Coal... situations. However, before any estimated or actual deduction may be taken, the lessee must submit a... paragraphs (c)(1)(v) and (c)(1)(vi) of this section, the lessee shall submit page one of the initial Form MMS...

30 CFR 210.153 - What reports must I submit for Indian gas valuation purposes?

Code of Federal Regulations, 2010 CFR

2010-07-01

... INTERIOR MINERALS REVENUE MANAGEMENT FORMS AND REPORTS Special-Purpose Forms and Reports-Oil, Gas, and Geothermal Resources § 210.153 What reports must I submit for Indian gas valuation purposes? (a) General. For... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What reports must I submit for Indian gas...

Heterologous Quaternary Structure of CXCL12 and its Relationship to the CC Chemokine Family

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murphy, J.; Yuan, H; Kong, Y

2010-01-01

X-ray crystallographic studies reveal that CXCL12 is able to form multiple dimer types, a traditional CXC dimer and a 'CC-like' form. Phylogenetic analysis of all known human chemokines demonstrates CXCL12 is more closely related to the CC chemokine class than other CXC chemokines. These observations indicate that CXCL12 contains genomic and structural elements characteristic of both CXC and CC chemokines.Chemokines are members of a superfamily of proteins involved in the migration of cells to the proper anatomical position during embryonic development or in response to infection or stress during an immune response. There are two major (CC and CXC) andmore » two minor (CX3C and XC) families based on the sequence around the first conserved cysteine. The topology of all structures is essentially identical with a flexible N-terminal region of 3-8 amino acids, a 10-20 residue N-terminal loop, a short 3{sub 10}-helix, three {beta}-strands, and a {alpha}-helix. The major consequence of the subtle difference between the families occurs at the oligomeric level. Monomers of the CC, CXC, and CX3C families form dimers in a family-specific manner. The XCL1 chemokine is a monomer that can interconvert between two folded states. All chemokines activate GPCRs according to family-specificity, however there are a few examples of chemokines crossing the family boundary to function as antagonists. A two-stage mechanism for chemokine activation of GPCRs has been proposed. The N-terminal region of the receptor interacts with the chemokine, followed by receptor activation by the chemokine N-terminal region. Monomeric chemokines have been demonstrated to be the active form for receptor function. There are numerous examples of both chemokines and their receptors forming dimers. While family-specific dimerization may be an attractive explanation for why specific chemokines only activate GPCRs within their own family, the role of dimers in the function of chemokines has not been resolved. Given that CXCL12 is in the CXC family, the CXC dimer is considered the physiologic dimer in all previous studies based on crystallographic evidence. NMR and mutational studies agree with the CXC dimer form in solution. The CXC form of the dimer is seen in recent structures of CXCL12 bound to a heparin disaccharide and several CXCR4 peptides. In one case, crystals of the CXC-type dimer were soaked in a heparin disaccharide solution to determine the interactions between this dimer and bound disaccharide. In another case, in order to overcome NMR chemical shift line broadening when CXCR4 peptides are added, a 'locked' dimer was constructed by introducing a cysteine mutant that linked subunits as a CXC dimer through an inter-subunit disulfide bond. The solution structures of the locked CXC dimer with CXCR4 peptides were determined. The locked CXC dimer retained Ca{sup 2+} mobilization yet lost chemotaxis activity, presumably because the monomer is the active form. In addition to existing as a monomer and CXC dimer, CXCL12 is now demonstrated to have the capacity to form CC type dimers in the presence of a CXCR4 peptide.« less

Mumps Photos

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Asbestos Photos

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Centchroman inhibits proliferation of head and neck cancer cells through the modulation of PI3K/mTOR Pathway

DOE Office of Scientific and Technical Information (OSTI.GOV)

Srivastava, Vikas Kumar; Gara, Rishi Kumar; Bhatt, M.L.B.

Research highlights: {yields} Centchroman (CC) inhibits cellular proliferation in HNSCC cells through the dual inhibition of PI3/mTOR pathway. {yields} CC treatment also inhibits STAT3 activation and alters expression of proteins involved in cell cycle regulation and DNA repair response in HNSCC cells. {yields} CC exhibits anti-proliferative activity in a variety of non-HNSCC cancer cell lines and is devoid of cytotoxicity to normal cell types of diverse origins. -- Abstract: Centchroman (CC; 67/20; INN: Ormeloxifene) is a non-steroidal antiestrogen extensively used as a female contraceptive in India. In the present study, we report the anti-proliferative effect of CC in head andmore » neck squamous cell carcinoma (HNSCC) cells. CC inhibited cell proliferation in a dose dependent manner at 24 h of treatment. Further studies showed that CC treatment induced apoptosis, inhibited Akt/mTOR and signal transducers and activators of transcription protein 3 (STAT3) signaling, altered proteins associated with cell cycle regulation and DNA damage and inhibited colony forming efficiency of HNSCC cells. In addition, CC displayed anti-proliferative activity against a variety of non-HNSCC cell lines of diverse origin. The ability of CC to serve as a dual-inhibitor of Akt/mTOR and STAT3 signaling warrants further studies into its role as a therapeutic strategy against HNSCC.« less

76 FR 31943 - Global Positioning System Directorate (Gpsd); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

...) Durations. All comments must be submitted in Comments Resolution Matrix (CRM) form. These forms along with... process for IS-GPS-200, IS-GPS-705, and IS-GPS-800. Please provide them in the CRM form and submit to Tony...

77 FR 37660 - ICWG Meeting for the NAVSTAR GPS Public Signals in Space

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... comments must be submitted in Comments Resolution Matrix (CRM) form. These forms along with the Was/Is...-GPS-705, and IS-GPS-800. Please provide them in the CRM form and submit to Tony Marquez by July 20...

27 CFR 73.32 - May I electronically sign forms I submit electronically to TTB?

Code of Federal Regulations, 2010 CFR

2010-04-01

... AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURES AND PRACTICES ELECTRONIC SIGNATURES; ELECTRONIC SUBMISSION OF FORMS Electronic Filing of Documents with TTB § 73.32 May I electronically sign forms I submit electronically to TTB? You may electronically sign the electronic form you...

Photos of Shingles

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Facts about Botulism

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Nodulation, Nitrogen Fixation, and Hydrogen Oxidation by Pigeon Pea Bradyrhizobium spp. in Symbiotic Association with Pigeon Pea, Cowpea, and Soybean †

PubMed Central

Nautiyal, C. S.; Hegde, S. V.; van Berkum, P.

1988-01-01

The pigeon pea strains of Bradyrhizobium CC-1, CC-8, UASGR(S), and F4 were evaluated for nodulation, effectiveness for N2 fixation, and H2 oxidation with homologous and nonhomologous host plants. Strain CC-1 nodulated Macroptilium atropurpureum, Vigna unguiculata, Glycine max, and G. soja but did not nodulate Pisum sativum, Phaseolus vulgaris, Trigonella foenum-graecum, and Trifolium repens. Strain F4 nodulated G. max cv. Peking and PI 434937 (Malayan), but the symbioses formed were poor. Similarly, G. max cv. Peking, cv. Bragg, PI 434937, PR 13-28-2-8-7, and HM-1 were nodulated by strain CC-1, and symbioses were also poor. G. max cv. Williams and cv. Clark were not nodulated. H2 uptake activity was expressed with pigeon pea and cowpea, but not with soybean. G. max cv. Bragg grown in Bangalore, India, in local soil not previously exposed to Bradyrhizobium japonicum formed nodules with indigenous Bradyrhizobium spp. Six randomly chosen isolates, each originating from a different nodule, formed effective symbioses with pigeon pea host ICPL-407, nodulated PR 13-28-2-8-7 soybean forming moderately effective symbioses, and did not nodulate Williams soybean. These results indicate the six isolates to be pigeon pea strains although they originated from soybean nodules. Host-determined nodulation of soybean by pigeon pea Bradyrhizobium spp. may depend upon the ancestral backgrounds of the cultivars. The poor symbioses formed by the pigeon pea strains with soybean indicate that this crop should be inoculated with B. japonicum for its cultivation in soils containing only pigeon pea Bradyrhizobium spp. PMID:16347542

Pathways to Oxygen-Bearing Molecules in the Interstellar Medium and in Planetary Atmospheres: Cyclopropenone (c-C3H2O) and Propynal (HCCCHO)

NASA Astrophysics Data System (ADS)

Zhou, Li; Kaiser, Ralf I.; Gao, Li Gyun; Chang, Agnes H. H.; Liang, Mao-Chang; Yung, Yuk L.

2008-10-01

We investigated the formation of two C3H2O isomers, i.e., cyclopropenone (c-C3H2O) and propynal (HCCCHO), in binary ice mixtures of carbon monoxide (CO) and acetylene (C2H2) at 10 K in an ultrahigh vacuum machine on high-energy electron irradiation. The chemical evolution of the ice samples was followed online and in situ via a Fourier transform infrared spectrometer and a quadrupole mass spectrometer. The temporal profiles of the cyclopropenone and propynal isomers suggest (pseudo-) first-order kinetics. The cyclic structure (c-C3H2O) is formed via an addition of triplet carbon monoxide to ground-state acetylene (or vice versa); propynal (HCCCHO) can be synthesized from a carbon monoxide-acetylene complex via a [HCO...CCH] radical pair inside the matrix cage. These laboratory studies showed for the first time that both C3H2O isomers can be formed in low-temperature ices via nonequilibrium chemistry initiated by energetic electrons as formed in the track of Galactic cosmic ray particles penetrating interstellar icy grains in cold molecular clouds. Our results can explain the hitherto unresolved gas phase abundances of cyclopropenone in star-forming regions via sublimation of c-C3H2O as formed on icy grains in the cold molecular cloud stage. Implications for the heterogeneous oxygen chemistry of Titan and icy terrestrial planets and satellites suggest that the production of oxygen-bearing molecules such as C3H2O may dominate on aerosol particles compared to pure gas phase chemistry.

Activity and Stability of Dispersed Multi Metallic Pt-based Catalysts for CO Tolerance in Proton Exchange Membrane Fuel Cell Anodes.

PubMed

Hassan, Ayaz; Ticianelli, Edson A

2018-01-01

Studies aiming at improving the activity and stability of dispersed W and Mo containing Pt catalysts for the CO tolerance in proton exchange membrane fuel cell (PEMFC) anodes are revised for the following catalyst systems: (1) a carbon supported PtMo electrocatalyst submitted to heat treatments; (2) Pt and PtMo nanoparticles deposited on carbon-supported molybdenum carbides (Mo2C/C); (3) ternary and quaternary materials formed by PtMoFe/C, PtMoRu/C and PtMoRuFe/C and; (4) Pt nanoparticles supported on tungsten carbide/carbon catalysts and its parallel evaluation with carbon supported PtW catalyst. The heat-treated (600 oC) Pt-Mo/C catalyst showed higher hydrogen oxidation activity in the absence and in the presence of CO and better stability, compared to all other Mo-containing catalysts. PtMoRuFe, PtMoFe, PtMoRu supported on carbon and Pt supported on Mo2C/C exhibited similar CO tolerances but better stability, as compared to as-prepared PtMo supported on carbon. Among the tungsten-based catalysts, tungsten carbide supported Pt catalyst showed reasonable performance and reliable stability in comparison to simple carbon supported PtW catalyst, though an uneven level of catalytic activity towards H2 oxidation in presence of CO is observed for the former as compared to Mo containing catalyst. However, a small dissolution of Mo, Ru, Fe and W from the anodes and their migration toward cathodes during the cell operation is observed. These results indicate that the fuel cell performance and stability has been improved but not yet totally resolved.

Coupled-cluster Green's function: Analysis of properties originating in the exponential parametrization of the ground-state wave function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, Bo; Kowalski, Karol

In this paper we derive basic properties of the Green’s function matrix elements stemming from the exponential coupled cluster (CC) parametrization of the ground-state wave function. We demon- strate that all intermediates used to express retarded (or equivalently, ionized) part of the Green’s function in the ω-representation can be expressed through connected diagrams only. Similar proper- ties are also shared by the first order ω-derivatives of the retarded part of the CC Green’s function. This property can be extended to any order ω-derivatives of the Green’s function. Through the Dyson equation of CC Green’s function, the derivatives of corresponding CCmore » self-energy can be evaluated analytically. In analogy to the CC Green’s function, the corresponding CC self-energy is expressed in terms of connected diagrams only. Moreover, the ionized part of the CC Green’s func- tion satisfies the non-homogeneous linear system of ordinary differential equations, whose solution may be represented in the exponential form. Our analysis can be easily generalized to the advanced part of the CC Green’s function.« less

Injuries and Mass Casualty Events

MedlinePlus

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Prevalence of substance use among middle school-aged e-cigarette users compared with cigarette smokers, nonusers, and dual users: Implications for primary prevention.

PubMed

Kristjansson, Alfgeir L; Mann, Michael J; Smith, Megan L

2017-01-01

The objective of this study was to compare the prevalence of substance use in e-cigarette (EC)-only users with combustible cigarette (CC)-only users, dual users, and nonusers in a large sample of middle school-aged adolescents. Population-based cross-sectional school survey conducted in 15 middle schools in 3 counties in West Virginia in the United States between October and December of 2015 (N = 6547, girls = 49.6%; response rate 84.7%). Approximately 4.3% of participants had used EC only, 4.5% had used CC only, and around 5.5% were dual users. Nonusers had the lowest prevalence of all 9 forms of substance use assessed in the study (i.e., chewing tobacco, any alcohol, drunkenness, marijuana, sniffing, prescription drugs, hallucinogens, synthetic marijuana, and bath salts), followed by EC and CC users. Dual users had the highest prevalence of 8 of 9 forms of substance use. Multinomial logistic regression models showed that EC-only users had significantly greater odds over nonusers of using 8 of 9 types of substances included in the study. Conversely, EC-only users had significantly lower odds of using 7 of 9 types of substances when compared with dual users. However, EC-only users did not differ from CC-only users in odds of use in any of the 9 substances included in this analysis. Among middle school-aged adolescents, EC-only users do not differ from CC-only users in odds for other forms of substance use. Primary prevention programs should consider EC use initiation as a pathway to greater risk of other licit and illicit substances among young adolescents.

77 FR 41663 - Surety Bond Guarantee Program-Quick Bond Application and Agreement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-16

... other things, clarify the procedures for submitting application forms and paying fees, and deletes an obsolete reference to a form. DATES: This rule is effective August 15, 2012. FOR FURTHER INFORMATION... SBG Program regulations, including clarifying the procedures for submitting application forms and...

Measuring Physical Activity Intensity

MedlinePlus Videos and Cool Tools

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7 CFR 28.56 - Form A and Form D memorandum.

Code of Federal Regulations, 2011 CFR

2011-01-01

... classification and/or comparison has been made of any samples submitted by the owner of the cotton or the owner's... Certificates and Memoranda § 28.56 Form A and Form D memorandum. (a) When a classification and/or comparison has been made of any samples submitted to a Classing Office direct from a public warehouse, the...

7 CFR 28.56 - Form A and Form D memorandum.

Code of Federal Regulations, 2010 CFR

2010-01-01

... classification and/or comparison has been made of any samples submitted by the owner of the cotton or the owner's... Certificates and Memoranda § 28.56 Form A and Form D memorandum. (a) When a classification and/or comparison has been made of any samples submitted to a Classing Office direct from a public warehouse, the...

75 FR 72847 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

..., Placement Service. The RRB currently utilizes four forms to obtain information needed to carry out its job... required to obtain or maintain a benefit. In addition, the RRB also collects Railroad Job Vacancies... Control Number: 3220-0057. Form(s) submitted: ES-2, ES-21, ES-21c, UI-35, and Job Vacancies Reports. Type...

14 CFR 330.29 - What information must air taxi operators submit on Form 330 (Final) and Form 330-C?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false What information must air taxi operators... COMPENSATION OF AIR CARRIERS Application Procedures § 330.29 What information must air taxi operators submit on Form 330 (Final) and Form 330-C? As an air taxi operator, you must complete Form 330 (Final) in...

14 CFR 330.29 - What information must air taxi operators submit on Form 330 (Final) and Form 330-C?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false What information must air taxi operators... COMPENSATION OF AIR CARRIERS Application Procedures § 330.29 What information must air taxi operators submit on Form 330 (Final) and Form 330-C? As an air taxi operator, you must complete Form 330 (Final) in...

Centchroman regulates breast cancer angiogenesis via inhibition of HIF-1α/VEGFR2 signalling axis.

PubMed

Dewangan, Jayant; Kaushik, Shweta; Rath, Srikanta Kumar; Balapure, Anil K

2018-01-15

Angiogenesis is a recognized hallmark of cancer which promotes cancer cell progression and metastasis. Inhibition of angiogenesis to attenuate cancer growth is becoming desirable strategy for breast cancer management. The present study is aimed to investigate the antiangiogenic efficacy of a novel selective estrogen receptor modulator Centchroman (CC) on human breast cancer cells. Effect of CC on cell viability was evaluated using Sulforhodamine B assay. Endothelial cell proliferation, wound healing, Boyden chamber cell invasion, tube formation and chorioallantoic membrane (CAM) assays were performed to assess the effect of CC on migration, invasion and angiogenesis. Apoptosis, reactive oxygen species generation, caspase-3/7 and intracellular calcium ion level were measured through flow cytometry. Expression levels of HIF-1α, VEGF, VEGFR2, AKT and ERK were assessed by western blot analysis. CC selectively induces apoptosis in human breast cancer cells without affecting non-tumorigenic breast epithelial cells MCF-10A. Moreover, it inhibits migratory, invasive and mammosphere forming potential of breast cancer. Furthermore, CC also inhibited VEGF-induced migration, invasion and tube formation of HUVECs in vitro. CC effectively inhibited neovasculature formation in chicken CAM. Western blot analysis demonstrated that CC inhibited expression of HIF-1α and its downstream target VEGF. Interestingly, CC also suppressed VEGFR2 phosphorylation and consequently attenuated AKT and ERK phosphorylation. Our findings suggest that CC downregulates VEGF-induced angiogenesis by modulating HIF-1α/VEGFR2 pathway and recommend it (CC) as a potential therapeutic drug for breast cancer treatment. Copyright © 2017 Elsevier Inc. All rights reserved.

[Optimal Ovulation Induction in Polycystic Ovary Syndrome Resistant to Clomiphene Citrate or Letrozole.

PubMed

Chen, Ying; Zhang, Dan

2016-11-01

To investigate the optimal ovulation induction with the combination of combining letrozole(LE),clomiphene citrate (CC),and human menopausal gonadotropin (HMG) in polycystic ovary syndrome(PCOS) patients resistant to CC or LE. Two hundreds nine PCOS patients (209 cycles) resistant to CC or LE were randomly divided into three groups: CC+HMG group (59 cycles),LE+HMG group (72 cycles) and LE+CC group (78 cycles).The patients in LE+CC group unable to form the dominant follicle after 54 cycles were enrolled into LE+CC+HMG group.Maximum follicle diameter (MFD),endometrial thickness,number of follicles (diameter>1.4 cm),the level of serum estradiol (E2) were measured on the day of HMG administration.Also these results were observed and compared including the duration of treatment,dosage of HMG,number of ovulated follicles,clinical pregnancy rate,biochemical pregnancy rate,early abortion rate,twinning rate,and ectopic pregnancy rate. The ovulation rate was significantly lower in LE+CC group (30.77%) ( P <0.05),but similar in the other three groups.The number of >1.4 cm follicles and ovulated follicles,ovulation duration and E2 concentration in LE+CC group were also at a lower level ( P <0.05).The patients in LE+CC+HMG group showed higher E2 level and more HMG consumption ( P <0.05).There was no statistical difference in endometrial thickness,MFD,clinical pregnancy rate,biochemical pregnancy rate,early abortion rate and twinning rate among these groups ( P >0.05).No severe ovarian hyperstimulation syndrome (OHSS) or luteinized unruptured follicle (LUF) occurred. Combintion of LE with CC could achieve 1/3 ovulation induction in PCOS resistant to CC or LE alone.When both combined with HMG,the induction of ovulation could be significantly higher than LE+HMG and CC+HMG,while the risk of multiple pregnancy and OHSS was reduced.

47 CFR 1.1158 - Form of payment for regulatory fees.

Code of Federal Regulations, 2012 CFR

2012-10-01

... regulatory fee payment (including a regulatory fee payment submitted with an application in the wireless radio service) made by credit card or money order must be submitted with a completed FCC Form 159...

47 CFR 1.1158 - Form of payment for regulatory fees.

Code of Federal Regulations, 2014 CFR

2014-10-01

... regulatory fee payment (including a regulatory fee payment submitted with an application in the wireless radio service) made by credit card or money order must be submitted with a completed FCC Form 159...

47 CFR 1.1158 - Form of payment for regulatory fees.

Code of Federal Regulations, 2013 CFR

2013-10-01

... regulatory fee payment (including a regulatory fee payment submitted with an application in the wireless radio service) made by credit card or money order must be submitted with a completed FCC Form 159...

27 CFR 73.31 - May I submit forms electronically to TTB?

Code of Federal Regulations, 2010 CFR

2010-04-01

... requirement in this chapter, only if: (a) We have published a notice in the Federal Register and on our Web... Register and on our Web site as stated above; (c) You submit the electronic form to an electronic document receiving system that we have designated for the receipt of that specific form; and (d) The electronic form...

Trimethyl phosphite as a trap for alkoxy radicals formed from the ring opening of oxiranylcarbinyl radicals. Conversion to alkenes. Mechanistic applications to the study of C-C versus C-O ring cleavage.

PubMed

Ding, Bangwei; Bentrude, Wesley G

2003-03-19

Trimethyl phosphite, (MeO)(3)P, is introduced as an efficient and selective trap in oxiranylcarbinyl radical (2) systems, formed from haloepoxides 8-13 under thermal AIBN/n-Bu(3)SnH conditions at about 80 degrees C. Initially, the transformations of 8-13, in the absence of phosphite, to allyl alcohol 7 and/or vinyl ether 5 were measured quantitatively (Table 1). Structural variations in the intermediate oxiranylcarbinyl (2), allyloxy (3), and vinyloxycarbinyl (4) radicals involve influences of the thermodynamics and kinetics of the C-O (2 --> 3, k(1)) and C-C (2 --> 4, k(2)) radical scission processes and readily account for the changes in the amounts of product vinyl ether (5) and allyl alcohol (7) formed. Added (MeO)(3)P is inert to vinyloxycarbinyl radical 4 and selectively and rapidly traps allyloxy radical 3, diverting it to trimethyl phosphate and allyl radical 6. Allyl radicals (6) dimerize or are trapped by n-Bu(3)SnH to give alkenes, formed from haloepoxides 8, 9, and 13 in 69-95% yields. Intermediate vinyloxycarbinyl radicals (4), in the presence or absence of (MeO)(3)P, are trapped by n-Bu(3)SnH to give vinyl ethers (5). The concentrations of (MeO)(3)P and n-Bu(3)SnH were varied independently, and the amounts of phosphate, vinyl ether (5), and/or alkene from haloepoxides 10, 11, and 13 were carefully monitored. The results reflect readily understood influences of changes in the structures of radicals 2-4, particularly as they influence the C-O (k(1)) and C-C (k(2)) cleavages of intermediate oxiranylcarbinyl radical 2 and their reverse (k(-1), k(-2)). Diversion by (MeO)(3)P of allyloxy radicals (3) from haloepoxides 11 and 12 fulfills a prior prediction that under conditions closer to kinetic control, products of C-O scission, not just those of C-C scission, may result. Thus, for oxiranylcarbinyl radicals from haloepoxides 11, 12, and 13, C-O scission (k(1), 2 --> 3) competes readily with C-C cleavage (k(2), 2 --> 4), even though C-C scission is favored thermodynamically.

Rodent Control: Seal Up! Trap Up! Clean Up!

MedlinePlus

... Skip directly to site content Start of Search Controls Search Form Controls Cancel Submit Search The CDC CDC A-Z ... V W X Y Z # Start of Search Controls Search Form Controls Cancel Submit Search The CDC ...

Infection Control: The Use and Handling of Toothbrushes

MedlinePlus

... Skip directly to site content Start of Search Controls Search Form Controls Cancel Submit Search the CDC CDC A-Z ... V W X Y Z # Start of Search Controls Search Form Controls Search The CDC Cancel Submit ...

Differential Stability of Dimeric and Monomeric Cytochrome c Oxidase Exposed to Elevated Hydrostatic Pressure†

PubMed Central

Staničová, Jana; Sedlák, Erik; Musatov, Andrej; Robinson, Neal C.

2007-01-01

Detergent-solubilized dimeric and monomeric cytochrome c oxidase (CcO) have significantly different quaternary stability when exposed to 2−3 kbar of hydrostatic pressure. Dimeric, dodecyl maltoside-solubilized cytochrome c oxidase is very resistant to elevated hydrostatic pressure with almost no perturbation of its quaternary structure or functional activity after release of pressure. In contrast to the stability of dimeric CcO, 3 kbar of hydrostatic pressure triggers multiple structural and functional alterations within monomeric cytochrome c oxidase. The perturbations are either irreversible or slowly reversible since they persist after the release of high pressure. Therefore, standard biochemical analytical procedures could be used to quantify the pressure-induced changes after the release of hydrostatic pressure. The electron transport activity of monomeric cytochrome c oxidase decreases by as much as 60% after exposure to 3 kbar of hydrostatic pressure. The irreversible loss of activity occurs in a time- and pressure-dependent manner. Coincident with the activity loss is a sequential dissociation of four subunits as detected by sedimentation velocity, high-performance ion-exchange chromatography, and reversed-phase and SDS–PAGE subunit analysis. Subunits VIa and VIb are the first to dissociate followed by subunits III and VIIa. Removal of subunits VIa and VIb prior to pressurization makes the resulting 11-subunit form of CcO even more sensitive to elevated hydrostatic pressure than monomeric CcO containing all 13 subunits. However, dimeric CcO, in which the association of VIa and VIb is stabilized, is not susceptible to pressure-induced inactivation. We conclude that dissociation of subunit III and/or VIIa must be responsible for pressure-induced inactivation of CcO since VIa and VIb can be removed from monomeric CcO without significant activity loss. These results are the first to clearly demonstrate an important structural role for the dimeric form of cytochrome c oxidase, i.e., stabilization of its quaternary structure. PMID:17530783

20 CFR 655.533 - What should be submitted for locations in Alaska?

Code of Federal Regulations, 2010 CFR

2010-04-01

... locations in Alaska? (a) Form ETA 9033-A with accompanying documentation. A completed and dated original Form ETA 9033-A, or facsimile transmission thereof, containing the required attestation elements and... with two copies of the completed, signed, and dated Form ETA 9033-A shall be submitted to ETA. (If the...

38 CFR 74.12 - What must a concern submit to apply for VetBiz VIP Verification Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... electronic documents, these manual records will provide the CVE verification examiner with sufficient... Verification applicant must submit the electronic forms and attachments CVE requires. All electronic forms are... dispatches the electronic forms, the applicant must also retain on file at the principal place of business a...

38 CFR 74.12 - What must a concern submit to apply for VetBiz VIP Verification Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... electronic documents, these manual records will provide the CVE verification examiner with sufficient... Verification applicant must submit the electronic forms and attachments CVE requires. All electronic forms are... dispatches the electronic forms, the applicant must also retain on file at the principal place of business a...

38 CFR 74.12 - What must a concern submit to apply for VetBiz VIP Verification Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... electronic documents, these manual records will provide the CVE verification examiner with sufficient... Verification applicant must submit the electronic forms and attachments CVE requires. All electronic forms are... dispatches the electronic forms, the applicant must also retain on file at the principal place of business a...

38 CFR 74.12 - What must a concern submit to apply for VetBiz VIP Verification Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... electronic documents, these manual records will provide the CVE verification examiner with sufficient... Verification applicant must submit the electronic forms and attachments CVE requires. All electronic forms are... dispatches the electronic forms, the applicant must also retain on file at the principal place of business a...

42 CFR 73.9 - Responsible Official.

Code of Federal Regulations, 2011 CFR

2011-10-01

... reported by submission of APHIS/CDC Form 4 within seven calendar days after identification. A copy of the... any other select agent or toxin, APHIS/CDC Form 4 must be submitted within seven calendar days after... agent or toxin, APHIS/CDC Form 4 must be submitted within 90 calendar days of receipt of the agent or...

26 CFR 1.6015-5 - Time and manner for requesting relief.

Code of Federal Regulations, 2014 CFR

2014-04-01

... equitable relief under § 1.6015-4, a requesting spouse must file Form 8857, “Request for Innocent Spouse Relief” (or other specified form); submit a written statement containing the same information required on Form 8857, which is signed under penalties of perjury; or submit information in the manner prescribed...

26 CFR 1.6015-5 - Time and manner for requesting relief.

Code of Federal Regulations, 2011 CFR

2011-04-01

... equitable relief under § 1.6015-4, a requesting spouse must file Form 8857, “Request for Innocent Spouse Relief” (or other specified form); submit a written statement containing the same information required on Form 8857, which is signed under penalties of perjury; or submit information in the manner prescribed...

Alternative initial proton acceptors for the D pathway of Rhodobacter sphaeroides cytochrome c oxidase

PubMed Central

Varanasi, Lakshman; Hosler, Jonathan

2011-01-01

In order to characterize protein structures that control proton uptake, forms of cytochrome c oxidase (CcO) containing a carboxyl or a thiol group in line with the initial, internal waters of the D pathway for proton transfer have been assayed in the presence and absence of subunit III. Subunit III provides approximately half of the protein surrounding the entry region of the D pathway. The mutant N139D-D132N contains a carboxyl group 6Å within the D pathway and lacks the normal, surface-exposed proton acceptor, Asp-132. With subunit III, the steady-state activity of this mutant is slow but once subunit III is removed its activity is the same as wild-type CcO lacking subunit III (∼1800 H+ s-1). Thus, a carboxyl group ∼25% within the pathway enhances proton uptake even though the carboxyl has no direct contact with bulk solvent. Protons from solvent apparently move to internal Asp-139 through a short file of waters, normally blocked by subunit III. Cysteine-139 also supports rapid steady-state proton uptake, demonstrating that an anion other than a carboxyl can attract and transfer protons into the D pathway. When both Asp-132 and Asp/Cys-139 are present, the removal of subunit III increases CcO activity to rates greater than that of normal CcO due to simultaneous proton uptake by two initial acceptors. The results show how the environment of the initial proton acceptor for the D pathway in these CcO forms dictates the pH range of CcO activity, with implications for the function of Asp-132, the normal proton acceptor. PMID:21344856

First Time Detection of C13CC and Study of 13CCC in Dense Star Forming Regions

NASA Astrophysics Data System (ADS)

Giesen, Thomas

Small carbon chain molecules play an important role in the formation of larger, complex molecules as well as in the destruction process of interstellar grains. Linear C3 was found in dense star forming regions and in shells of late type carbon stars. In the course of recent SOFIA cycle 4 observations we made a first time detection of the 13C-isotopologue 13CCC in space. Asymmetrically substituted 13CCC transitions were detected based on recent unpublished laboratory data. Following this detection we propose to look for the yet undetected C13CC isotopologue and to observe higher-J Q-transitions for both isotopologues. The measurements aim to determine the 13CCC/C13CC ratio which equals 2 for random 13C-incorporation during the C3 formation process. A non-random, chemically driven 13CCC/C13CC ratio will shed light on possible routes to C3-formation. Furthermore high level J-transitions are sensitive to the prevailing excitation conditions. Below 50K symmetrically substituted C13CC can only be cooled by collisions with the ambient gas, whereas asymmetrically substituted 13CCC is cooled by collisions AND radiation thanks to a small permanent dipole moment. Thus 13CCC/C13CC-intensity ratios of the Q(8) line will give insights into excitation mechanism and temperatures of C3. For the new measurements we choose SgrB2(M) as source in order to compare line strengths of C3 and its 13C-isotopologues at exactly the same conditions than we had in our previous CCC observations.

Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer

PubMed Central

Cano, Carla E; Sandí, María José; Hamidi, Tewfik; Calvo, Ezequiel L; Turrini, Olivier; Bartholin, Laurent; Loncle, Céline; Secq, Véronique; Garcia, Stéphane; Lomberk, Gwen; Kroemer, Guido; Urrutia, Raul; Iovanna, Juan L

2012-01-01

Pancreatic adenocarcinoma (PDAC) is an extremely deadly disease for which all treatments available have failed to improve life expectancy significantly. This may be explained by the high metastatic potential of PDAC cells, which results from their dedifferentiation towards a mesenchymal phenotype. Some PDAC present cell-in-cell structures whose origin and significance are currently unknown. We show here that cell-in-cells form after homotypic cell cannibalism (HoCC). We found PDAC patients whose tumours display HoCC develop less metastasis than those without. In vitro, HoCC was promoted by inactivation of the nuclear protein 1 (Nupr1), and was enhanced by treatment with transforming growth factor β. HoCC ends with death of PDAC cells, consistent with a metastasis suppressor role for this phenomenon. Hence, our data indicates a protective role for HoCC in PDAC and identifies Nupr1 as a molecular regulator of this process. PMID:22821859

Auditory interhemispheric transfer in relation to patterns of partial agenesis and hypoplasia of the corpus callosum in spina bifida meningomyelocele

PubMed Central

Hannay, H. Julia; Walker, Amy; Dennis, Maureen; Kramer, Larry; Blaser, Susan; Fletcher, Jack M.

2009-01-01

Spina bifida meningomyelocele with hydrocephalus (SBM) is commonly associated with anomalies of the corpus callosum (CC). We describe MRI patterns of regional CC agenesis and relate CC anomalies to functional laterality based on a dichotic listening test in 90 children with SBM and 27 typically developing controls. Many children with SBM (n = 40) showed regional CC anomalies in the form of agenesis of the rostrum and0or splenium, and a smaller number (n = 20) showed hypoplasia (thinning) of all CC regions (rostrum, genu, body, and splenium). The expected right ear advantage (REA) was exhibited by normal controls and children with SBM having a normal or hypoplastic splenium. It was not shown by children with SBM who were left handed, missing a splenium, or had a higher level spinal cord lesion. Perhaps the right hemisphere of these children is more involved in processing some aspects of linguistic stimuli. PMID:18764972

A dense and strong bonding collagen film for carbon/carbon composites

NASA Astrophysics Data System (ADS)

Cao, Sheng; Li, Hejun; Li, Kezhi; Lu, Jinhua; Zhang, Leilei

2015-08-01

A strong bonding collagen film was successfully prepared on carbon/carbon (C/C) composites. The surface conditions of the modified C/C composites were detected by contact angle measurements, scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS) and Raman spectra. The roughness, optical morphology, bonding strength and biocompatibility of collagen films at different pH values were detected by confocal laser scanning microscope (CLSM), universal test machine and cytology tests in vitro. After a 4-h modification in 30% H2O2 solution at 100 °C, the contact angle on the surface of C/C composites was decreased from 92.3° to 65.3°. Large quantities of hydroxyl, carboxyl and carbonyl functional groups were formed on the surface of the modified C/C composites. Then a dense and continuous collagen film was prepared on the modified C/C substrate. Bonding strength between collagen film and C/C substrate was reached to 8 MPa level when the pH value of this collagen film was 2.5 after the preparing process. With 2-day dehydrathermal treatment (DHT) crosslinking at 105 °C, the bonding strength was increased to 12 MPa level. At last, the results of in vitro cytological test showed that this collagen film made a great improvement on the biocompatibility on C/C composites.

The influence of FLiNaK salt impregnation on the mechanical properties of a 2D woven C/C composite

NASA Astrophysics Data System (ADS)

Zhang, Dongsheng; Xia, Huihao; Yang, Xinmei; Feng, Shanglei; Song, Jinliang; Zhou, Xingtai

2017-03-01

Impregnating of molten LiF-NaF-KF salt (LiF-NaF-KF: 46.5-11.5-42 mol%, FLiNaK) into a 2D woven C/C composite was performed at 650 °C under different pressure. The weight gain and mechanical properties change of the 2D woven C/C composite after FLiNaK salt impregnation were measured. The FLiNaK salt distribution into the 2D woven C/C composite was observed by X-ray computed tomography (X-ray CT) and scanning electron microscopy. The results showed that the weight gain of the 2D woven C/C composite increased with increasing impregnating pressure. In X-ray CT images, FLiNaK salt was distributed into the open pores and fissures among fiber bundles and neighboring plies. The interlaminar shear strength, compressive strength, and flexural strength of the 2D woven C/C composite increased with the increase of weight gain. The influence of FLiNaK salt impregnation on the mechanical properties was attributed to the coupling effect of re-densification of FLiNaK salt impregnation and residual stress formed in 2D woven C/C composite.

Guidance Documents and Sample Forms for Central Data Exchange (CDX) Registration and e-PMN Software (Thin Client)

EPA Pesticide Factsheets

For users submitting electronic notices through CDX, this page contains guidance documents and sample forms to help you, submit Premanufacture Notices (PMN), Bona Fide and biotechnology notices, among others.

Assistance with Obtaining a Replacement Card Form

EPA Pesticide Factsheets

Form to be submitted to Section 608 Technician Certification Program Manager if a technician wants to replace a certification card, and the record of the original certification is in the data submitted by companies that have gone out of business.

Theoretical investigation of the reaction of Mn+ with ethylene oxide.

PubMed

Li, Yuanyuan; Guo, Wenyue; Zhao, Lianming; Liu, Zhaochun; Lu, Xiaoqing; Shan, Honghong

2012-01-12

The potential energy surfaces of Mn(+) reaction with ethylene oxide in both the septet and quintet states are investigated at the B3LYP/DZVP level of theory. The reaction paths leading to the products of MnO(+), MnO, MnCH(2)(+), MnCH(3), and MnH(+) are described in detail. Two types of encounter complexes of Mn(+) with ethylene oxide are formed because of attachments of the metal at different sites of ethylene oxide, i.e., the O atom and the CC bond. Mn(+) would insert into a C-O bond or the C-C bond of ethylene oxide to form two different intermediates prior to forming various products. MnO(+)/MnO and MnH(+) are formed in the C-O activation mechanism, while both C-O and C-C activations account for the MnCH(2)(+)/MnCH(3) formation. Products MnO(+), MnCH(2)(+), and MnH(+) could be formed adiabatically on the quintet surface, while formation of MnO and MnCH(3) is endothermic on the PESs with both spins. In agreement with the experimental observations, the excited state a(5)D is calculated to be more reactive than the ground state a(7)S. This theoretical work sheds new light on the experimental observations and provides fundamental understanding of the reaction mechanism of ethylene oxide with transition metal cations.

Molecular and functional roles of 6C CC chemokine 19 in defense system of striped murrel Channa striatus.

PubMed

Arockiaraj, Jesu; Bhatt, Prasanth; Harikrishnan, Ramasamy; Arasu, Mariadhas Valan; Al-Dhabi, Naif Abdullah

2015-08-01

In this study, we have reported the molecular information of chemokine-19 (Chem19) from striped murrel Channa striatus (Cs). CsCC-Chem19 cDNA sequence was 555 base pair (bp) in length which is 68bp 5' untranslated region (UTR), 339bp translated region and 149bp 3' UTR. The translated region is encoded for a polypeptide of 112 amino acids. CsCC-Chem19 peptide contains a signal sequence between 1 and 26 and an interleukin (IL) 8 like domain between 24 and 89. The multiple sequence alignment showed a 'DCCL' motif, an indispensable motif present in all CC chemokines which was conserved throughout the evolution. Phylogenetic tree showed that CsCC-Chem19 formed a cluster with chemokine 19 from fishes. Secondary structure of CsCC-Chem19 revealed that the peptide contains maximum amount of coils (61.6%) compared to α-helices (25.9%%) and β-sheet (12.5%). Further, 3D analysis indicated that the cysteine residues at 33, 34, 59 and 75 making the disulfide bridges as 33 = 59 and 34 = 75. Significantly (P < 0.05) highest CsCC-Chem19 mRNA expression was observed in blood and it was up-regulated upon fungus and bacterial infection. Utilizing the coding region of CsCC-Chem19, recombinant CsCC-Chem19 protein was produced. The recombinant CsCC-Chem19 protein induced the cellular proliferation and respiratory burst activity of C. striatus peripheral blood leukocytes (PBL) in a concentration dependent manner. Moreover, the chemotactic activity showed that the recombinant CsCC-Chem19 significantly (P < 0.05) enhanced the movement of PBL of C. striatus. Conclusively, CsCC-Chem19 is a 6C CC chemokine having an ability to perform both inflammatory and homeostatic functions. However, further research is necessary to understand the potential of 6C CC chemokine 19 of C. striatus, particularly their regulatory ability on different cellular components in the defense system. Copyright © 2015 Elsevier Ltd. All rights reserved.

30 CFR 218.41 - Assessments for failure to submit payment of same amount as Form MMS-2014 or bill document or to...

Code of Federal Regulations, 2010 CFR

2010-07-01

... same amount as Form MMS-2014 or bill document or to provide adequate information. 218.41 Section 218.41... Assessments for failure to submit payment of same amount as Form MMS-2014 or bill document or to provide... equivalent in amount to the total of individual line items on the associated Form MMS-2014, Form MMS-4430, or...

An homolog of the Frz Phosphoenolpyruvate:carbohydrate phosphoTransferase System of extraintestinal pathogenic Escherichia coli is encoded on a genomic island in specific lineages of Streptococcus agalactiae.

PubMed

Patron, Kévin; Gilot, Philippe; Camiade, Emilie; Mereghetti, Laurent

2015-06-01

We identified a Streptococcus agalactiae metabolic region (fru2) coding for a Phosphoenolpyruvate:carbohydrate phosphoTransferase System (PTS) homologous to the Frz system of extraintestinal pathogenic Escherichia coli strains. The Frz system is involved in environmental sensing and regulation of the expression of adaptation and virulence genes in E. coli. The S. agalactiae fru2 region codes three subunits of a PTS transporter of the fructose-mannitol family, a transcriptional activator of PTSs of the MtlR family, an allulose-6 phosphate-3-epimerase, a transaldolase and a transketolase. We demonstrated that all these genes form an operon. The fru2 operon is present in a 17494-bp genomic island. We analyzed by multilocus sequence typing a population of 492 strains representative of the S. agalactiae population and we showed that the presence of the fru2 operon is linked to the phylogeny of S. agalactiae. The fru2 operon is always present within strains of clonal complexes CC 1, CC 7, CC 10, CC 283 and singletons ST 130 and ST 288, but never found in other CCs and STs. Our results indicate that the fru2 operon was acquired during the evolution of the S. agalactiae species from a common ancestor before the divergence of CC 1, CC 7, CC 10, CC 283, ST 130 and ST 288. As S. agalactiae strains of CC 1 and CC 10 are frequently isolated from adults with invasive disease, we hypothesize that the S. agalactiae Fru2 system senses the environment to allow the bacterium to adapt to new conditions encountered during the infection of adults. Copyright © 2015 Elsevier B.V. All rights reserved.

Rhenium complexes of bidentate, bis-bidentate and tridentate N-heterocyclic carbene ligands.

PubMed

Chan, Chung Ying; Barnard, Peter J

2015-11-28

A series of eight Rhenium(I)-N-heterocyclic carbene (NHC) complexes of the general form [ReCl(CO)3(C^C)] (where C^C is a bis(NHC) bidentate ligand), [ReCl(CO)3(C^C)]2 (where C^C is a bis-bidentate tetra-NHC ligand) and [Re(CO)3(C^N^C)](+)[X](-) (where C^N^C is a bis(NHC)-amine ligand and the counter ion X is either the ReO4(-) or PF6(-)) have been synthesised using a Ag2O transmetallation protocol. The novel precursor imidazolium salts and Re(I) complexes were characterized by elemental analysis, (1)H and (13)C NMR spectroscopy and the molecular structures for two imidazolium salt and six Re(I) complexes were determined by single crystal X-ray diffraction. These NHC ligand systems are of interest for possible applications in the development of Tc-99m or Re-186/188 radiopharmaceuticals and as such the stability of two complexes of the form [ReCl(CO)3(C^C)] and [Re(CO)3(C^N^C)][ReO4] were evaluated in ligand challenge experiments using the metal binding amino acids L-histidine or L-cysteine. These studies showed that the former was unstable, with the chloride ligand being replaced by either cysteine or histidine, while no evidence for transchelation was observed for the latter suggesting that bis(NHC)-amine ligands of this type may be suitable for biological applications.

An Aerobic Digestion of Lime Sludge.

DTIC Science & Technology

1982-07-01

removal. 1,2 After lime addition, phosphorus is considered to be in the form of calcium hydroxyapatite (Ca5-(OH)(P04 )3 ), which will not resolubilize...U: c a e - ~ -’ tr *cr. V. (r. C . -~~~ C c C C&c cj Ir u -. C Fy. - U C C - C F.~-cc 0.c gC - - gg MFC - - C -66 TABLE 20. SUMMARY OF LEAST

Frequent Questions about the Manifest Registry

EPA Pesticide Factsheets

FAQs Including Can I submit multiple form samples to the EPA Registry for approval? Must I submit a continuation sheet sample to the Manifest Registry under section 262.21(d)? Can I typeset the form after I am approved to print the manifest?

Synthesis and physicochemical studies of amyloidogenic hexapeptides derived from human cystatin C.

PubMed

Iłowska, Emilia; Sawicka, Justyna; Szymańska, Aneta

2018-06-01

Human cystatin C (hCC) is a low molecular mass protein that belongs to the cystatin superfamily. It is an inhibitor of extracellular cysteine proteinases, present in all human body fluids. At physiological conditions, hCC is a monomer, but it has a tendency to dimerization. Naturally occurring hCC mutant, with leucine in position 68 substituted by glutamine (L68Q), is directly involved in the formation of amyloid deposits, independently of other proteins. This process is the primary cause of hereditary cerebral amyloid angiopathy, observed mainly in the Icelandic population. Oligomerization and fibrillization processes of hCC are not explained equally well, but it is proposed that domain swapping is involved in both of them. Research carried out on the fibrillization process led to new hypothesis about the existence of a steric zipper motif in amyloidogenic proteins. In the hCC sequence, there are 2 fragments which may play the role of a steric zipper: the loop L1 region and the C-terminal fragment. In this work, we focused on the first of these. Nine hexapeptides covering studied hCC fragment were synthesized, and their fibrillogenic potential was assessed using an array of biophysical methods. The obtained results showed that the studied hCC fragment has strong profibrillogenic propensities because it contains 2 fragments fulfilling the requirements for an effective steric zipper located next to each other, forming 1 super-steric zipper motif. This hCC fragment might therefore be responsible for the enhanced amyloidogenic properties of dimeric or partially unfolded hCC. Copyright © 2018 European Peptide Society and John Wiley & Sons, Ltd.

76 FR 66805 - Endangered and Threatened Wildlife and Plants: Final Rulemaking To Designate Critical Habitat for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-27

... which 4,843 were form letters submitted by supporters of the Center for Biological Diversity (CBD) and 20 were nearly identical to the form letters but included additional information. Comments were also... abalone and its habitat. Comment 29: In one of the form letters submitted by a supporter of CBD, one...

75 FR 35776 - Commission Information Collection Activities (FERC Form No. 80); Comment Request; Submitted for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... Information Collection Activities (FERC Form No. 80); Comment Request; Submitted for OMB Review June 16, 2010... interested person may file comments directly with OMB and should address a copy of those comments to the.../2010) requesting public comments. FERC received no comments on the FERC Form No. 80 and has made this...

77 FR 44696 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... the social security equivalent and non- social security equivalent portions of Tier I, Tier II, vested... OMB control number of the ICR. For proper consideration of your comments, it is best if the RRB and... and Compensation Reports. OMB Control Number: 3220-0014. Form(s) submitted: DC-2 and DC-2a. Type of...

Clustering in complex directed networks

NASA Astrophysics Data System (ADS)

Fagiolo, Giorgio

2007-08-01

Many empirical networks display an inherent tendency to cluster, i.e., to form circles of connected nodes. This feature is typically measured by the clustering coefficient (CC). The CC, originally introduced for binary, undirected graphs, has been recently generalized to weighted, undirected networks. Here we extend the CC to the case of (binary and weighted) directed networks and we compute its expected value for random graphs. We distinguish between CCs that count all directed triangles in the graph (independently of the direction of their edges) and CCs that only consider particular types of directed triangles (e.g., cycles). The main concepts are illustrated by employing empirical data on world-trade flows.

30 CFR 210.203 - How do I submit sales contracts?

Code of Federal Regulations, 2010 CFR

2010-07-01

... royalty terms. (b) When to submit. (1) For coal and metal production, you must submit the required... MANAGEMENT FORMS AND REPORTS Production and Royalty Reports-Solid Minerals § 210.203 How do I submit sales..., and phosphate production, and production from any other lease with ad valorem royalty terms, you must...

The CARMEN software as a service infrastructure.

PubMed

Weeks, Michael; Jessop, Mark; Fletcher, Martyn; Hodge, Victoria; Jackson, Tom; Austin, Jim

2013-01-28

The CARMEN platform allows neuroscientists to share data, metadata, services and workflows, and to execute these services and workflows remotely via a Web portal. This paper describes how we implemented a service-based infrastructure into the CARMEN Virtual Laboratory. A Software as a Service framework was developed to allow generic new and legacy code to be deployed as services on a heterogeneous execution framework. Users can submit analysis code typically written in Matlab, Python, C/C++ and R as non-interactive standalone command-line applications and wrap them as services in a form suitable for deployment on the platform. The CARMEN Service Builder tool enables neuroscientists to quickly wrap their analysis software for deployment to the CARMEN platform, as a service without knowledge of the service framework or the CARMEN system. A metadata schema describes each service in terms of both system and user requirements. The search functionality allows services to be quickly discovered from the many services available. Within the platform, services may be combined into more complicated analyses using the workflow tool. CARMEN and the service infrastructure are targeted towards the neuroscience community; however, it is a generic platform, and can be targeted towards any discipline.

Aristolochic Acid in the Etiology of Renal Cell Carcinoma

PubMed Central

Hoang, Margaret L.; Chen, Chung-Hsin; Chen, Pau-Chung; Roberts, Nicholas J.; Dickman, Kathleen G.; Yun, Byeong Hwa; Turesky, Robert J.; Pu, Yeong-Shiau; Vogelstein, Bert; Papadopoulos, Nickolas; Grollman, Arthur P.; Kinzler, Kenneth W.; Rosenquist, Thomas A.

2017-01-01

Background Aristolochia species used in the practice of traditional herbal medicine contains aristolochic acid (AA), an established human carcinogen contributing to urothelial carcinomas of the upper urinary tract. AA binds covalently to genomic DNA, forming aristolactam (AL)–DNA adducts. Here we investigated whether AA is also an etiologic factor in clear cell renal cell carcinoma (ccRCC). Methods We conducted a population-based case–control study to investigate the linkage between Aristolochia prescription history, cumulative AA consumption, and ccRCC incidence in Taiwan (5,709 cases and 22,836 matched controls). The presence and level of mutagenic dA-AL-I adducts were determined in the kidney DNA of 51 Taiwanese ccRCC patients. The whole-exome sequences of ccRCC tumors from 10 Taiwanese ccRCC patients with prior exposure to AA were determined. Results Cumulative ingestion of more than 250 mg of AA increased risk of ccRCC (OR, 1.25), and we detected dA-AL-I adducts in 76% of Taiwanese ccRCC patients. Furthermore, the distinctive AA mutational signature was evident in six of 10 sequenced ccRCC exomes from Taiwanese patients. Conclusions This study strongly suggests that AA contributes to the etiology of certain RCCs. Impact The current study offers compelling evidence implicating AA in a significant fraction of the RCC arising in Taiwan and illustrates the power of integrating epidemiologic, molecular, and genetic data in the investigation of cancer etiology. PMID:27555084

Centers for Disease Control and Prevention, Office of Minority Health & Health Equity (OMHHE)

MedlinePlus

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7 CFR 3052.320 - Report submission.

Code of Federal Regulations, 2010 CFR

2010-01-01

... audit shall be completed and the data collection form and reporting package shall be submitted within... is limited to the data elements prescribed by OMB. (c) Reporting package. The reporting package shall... not submitted the required data collection forms and reporting packages. (i) Clearinghouse address...

7 CFR 3052.320 - Report submission.

Code of Federal Regulations, 2011 CFR

2011-01-01

... audit shall be completed and the data collection form and reporting package shall be submitted within... is limited to the data elements prescribed by OMB. (c) Reporting package. The reporting package shall... not submitted the required data collection forms and reporting packages. (i) Clearinghouse address...

7 CFR 3052.320 - Report submission.

Code of Federal Regulations, 2013 CFR

2013-01-01

... audit shall be completed and the data collection form and reporting package shall be submitted within... is limited to the data elements prescribed by OMB. (c) Reporting package. The reporting package shall... not submitted the required data collection forms and reporting packages. (i) Clearinghouse address...

7 CFR 3052.320 - Report submission.

Code of Federal Regulations, 2012 CFR

2012-01-01

... audit shall be completed and the data collection form and reporting package shall be submitted within... is limited to the data elements prescribed by OMB. (c) Reporting package. The reporting package shall... not submitted the required data collection forms and reporting packages. (i) Clearinghouse address...

7 CFR 3052.320 - Report submission.

Code of Federal Regulations, 2014 CFR

2014-01-01

... audit shall be completed and the data collection form and reporting package shall be submitted within... is limited to the data elements prescribed by OMB. (c) Reporting package. The reporting package shall... not submitted the required data collection forms and reporting packages. (i) Clearinghouse address...

Department of the Army Justification of Estimates for Fiscal Year 1987, Submitted to Congress February 1986. Operation and Maintenance, Army. Volume 1.

DTIC Science & Technology

1986-02-01

Izu ac)L 4)V C rio 2C E-4-4 in 0) M) V VOz V C 0 d 0C 0 C)4 0 C 4 tiC r. . a) ". HL 1- o 0) CC -4 A.) w 4 1-4 :5 c) r_ cC c Ř 0 0 w) W4 0 P-4 a) 0 S 0...CL.C 0.491 hi% % A ~ 9.~§~: ~:~-:*~~.*.-~*:*~~; o~-a’~--o~"T q - 0 t- O OC M -Z oo ’- -- iP - LL. 00 -)N - - CYu LLL; 00-0’JUL) . 0 C n% coO 0 TN N: O om...Crzjz 41 - . *1 4-a 4. -4 . A~’i m* * W0 : ) c a): (0 4.. S 4.10t - *1 5.n- *0 M* -4 0 cn 0 12 ’a .3 w8 -4 C14 0 w . 0 4-4 C ~ 0 * *~ 4J CZ4 ~ 5 D IP tv r

Human Factors Validation of the AeroForm Tissue Expander System for Breast Reconstruction.

PubMed

Kelley, Kathy; Kim, Jennie

The tissue expansion process using traditional saline expanders is lengthy and uncomfortable. A new technology has been developed, providing a needle-free option implanted after a mastectomy, and is activated by a handheld remote control releasing small amounts (10 cc) of carbon dioxide from an internal reservoir. The expander is gradually filled with CO2 resulting in mechanical stretching of the overlying tissue. The AeroForm System has been evaluated in a series of clinical trials including a randomized, controlled U.S. study comparing the AeroForm System with saline expanders. Results demonstrated patients can safely and reliably dose and complete their expansions in half the time compared to saline expanders. A human factors validation study was conducted in 8 patients to evaluate whether patients could correctly use the device to complete their expansion at home. The sessions were recorded and data on performance, behavioral, and subjective measures were collected and analyzed and submitted to the FDA as part of the U.S. marketing approval. All 8 participants were successful in using the controller to deliver a simulated dose. Participants found the device easy to use and the training material provided adequate to understand use of the controller. For women who choose 2-stage breast reconstruction, a new safe and effective option is available for tissue expansion, offering a convenient and empowering alternative. The human factors validation study conducted confirmed the simplicity of the device and further validated that the device can be used safely and effectively for breast tissue expansion.

Integrative Pericyclic Cascade: An Atom Economic, Multi C-C Bond-Forming Strategy for the Construction of Molecular Complexity.

PubMed

Tejedor, David; Delgado-Hernández, Samuel; Peyrac, Jesús; González-Platas, Javier; García-Tellado, Fernando

2017-07-26

An all-pericyclic manifold is developed for the construction of topologically diverse, structurally complex and natural product-like polycyclic chemotypes. The manifold uses readily accessible tertiary propargyl vinyl ethers as substrates and imidazole as a catalyst to form up to two new rings, three new C-C bonds, six stereogenic centers and one transannular oxo-bridge. The manifold is efficient, scalable and instrumentally simple to perform and entails a propargyl Claisen rearrangement-[1,3]H shift, an oxa-6π-electrocyclization, and an intramolecular Diels-Alder reaction. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Abell 1142 and the Missing Central Galaxy – A Cluster in Transition?

NASA Astrophysics Data System (ADS)

Jones, Alexander; Su, Yuanyuan; Buote, David; Forman, William; van Weeren, Reinout; Jones, Christine; Gastaldello, Fabio; Kraft, Ralph; Randall, Scott

2018-01-01

Two types of galaxy clusters exist: cool core (CC) clusters which exhibit centrally-peaked metallicity and X-ray emission and non-cool core (NCC) clusters, possessing comparably homogeneous metallicity and X-ray emission distributions. However, the origin of this dichotomy is still unknown. The current prevailing theories state that either there is a primordial entropy limit, above which a CC is unable to form, or that clusters can change type through major mergers and radiative cooling. Abell 1142 is a galaxy cluster that can provide a unique probe of the root of this cluster-type division. It is formed of two merging sub-clusters, each with its own brightest cluster galaxies (BCG). Its enriched X-ray centroid (possible CC remnant) lies between these two BCGs. We present the thermal and chemical distributions of this system using deep (180ks) XMM-Newton observations to shed light on the role of mergers in the evolution of galaxy clusters.

The formation of RCCCO and CCC(O)R (R = Me, Ph) neutral radicals from ionic precursors in the gas phase: the rearrangement of CCC(O)Ph.

PubMed

Peppe, Salvatore; McAnoy, Andrew M; Dua, Suresh; Bowie, John H

2004-01-01

Neutrals MeCCCO, CCC(O)Me, PhCCCO and CCC(O)Ph have been made by neutralisation of [MeCCCO](+), [CCC(O)Me](-), [PhCCCO](+) and [CC(CO)Ph](-). Neutrals MeCCCO, CCC(O)Me and PhCCCO are stable for the microsecond duration of the neutralisation experiment. A joint experimental and theoretical study (energies calculated at the B3LYP/aug-cc-pVDZ//B3LYP/6-31G(d) level of theory) suggests that the neutral radical CCC(O)Ph rearranges via a four-centred ipso radical cyclisation/ring opening to form the isomer PhCCCO in an exothermic reaction. (13)C labelling confirms that the rearrangement does not involve O migration. Some of the PhCCCO radicals formed in this reaction are sufficiently energised to effect decomposition to give PhCC and CO. Copyright 2004 John Wiley & Sons, Ltd.

20 CFR 10.331 - How and when should the medical report be submitted?

Code of Federal Regulations, 2010 CFR

2010-04-01

... medical report be submitted? (a) Form CA-16 may be used for the initial medical report, while Form CA-20... employee or the physician. (See also § 10.210.) The employer may request a copy of the report from OWCP. The employer should use Form CA-17 to obtain interim reports concerning the duty status of an employee...

20 CFR 10.331 - How and when should the medical report be submitted?

Code of Federal Regulations, 2011 CFR

2011-04-01

... medical report be submitted? (a) Form CA-16 may be used for the initial medical report, while Form CA-20... employee or the physician. (See also § 10.210.) The employer may request a copy of the report from OWCP. The employer should use Form CA-17 to obtain interim reports concerning the duty status of an employee...

76 FR 39813 - Notice of Funding Availability of Applications (NOFA) for Section 514 Farm Labor Housing Loans...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

...- application. If leveraged funds are in the form of tax credits, the applicant must document that it has... provide an electronic copy of all hard copy forms and documents submitted in the pre-application/ application package as requested by this Notice. The forms and documents must be submitted to the appropriate...

8 CFR 322.3 - How, where, and what forms and other documents should the United States citizen parent(s) file?

Code of Federal Regulations, 2011 CFR

2011-01-01

... DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS CHILD BORN OUTSIDE THE UNITED STATES; REQUIREMENTS... citizenship under this section on behalf of a biological child shall be submitted on Form N-600, Application... citizenship under this section on behalf of an adopted child shall be submitted on Form N-643, Application for...

25 CFR 224.54 - How must a tribe submit an application?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false How must a tribe submit an application? 224.54 Section... Obtaining Tribal Energy Resource Agreements Processing Applications § 224.54 How must a tribe submit an application? A tribe must submit an application and all supporting documents in written and electronic form to...

25 CFR 224.54 - How must a tribe submit an application?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true How must a tribe submit an application? 224.54 Section 224... Obtaining Tribal Energy Resource Agreements Processing Applications § 224.54 How must a tribe submit an application? A tribe must submit an application and all supporting documents in written and electronic form to...

25 CFR 224.54 - How must a tribe submit an application?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false How must a tribe submit an application? 224.54 Section... Obtaining Tribal Energy Resource Agreements Processing Applications § 224.54 How must a tribe submit an application? A tribe must submit an application and all supporting documents in written and electronic form to...

25 CFR 224.54 - How must a tribe submit an application?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false How must a tribe submit an application? 224.54 Section... Obtaining Tribal Energy Resource Agreements Processing Applications § 224.54 How must a tribe submit an application? A tribe must submit an application and all supporting documents in written and electronic form to...

Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma

PubMed Central

Mehdi, Ali; Riazalhosseini, Yasser

2017-01-01

Clear cell renal cell carcinoma (ccRCC), the most common form of Kidney cancer, is characterized by frequent mutations of the von Hippel-Lindau (VHL) tumor suppressor gene in ~85% of sporadic cases. Loss of pVHL function affects multiple cellular processes, among which the activation of hypoxia inducible factor (HIF) pathway is the best-known function. Constitutive activation of HIF signaling in turn activates hundreds of genes involved in numerous oncogenic pathways, which contribute to the development or progression of ccRCC. Although VHL mutations are considered as drivers of ccRCC, they are not sufficient to cause the disease. Recent genome-wide sequencing studies of ccRCC have revealed that mutations of genes coding for epigenome modifiers and chromatin remodelers, including PBRM1, SETD2 and BAP1, are the most common somatic genetic abnormalities after VHL mutations in these tumors. Moreover, recent research has shed light on the extent of abnormal epigenome alterations in ccRCC tumors, including aberrant DNA methylation patterns, abnormal histone modifications and deregulated expression of non-coding RNAs. In this review, we discuss the epigenetic modifiers that are commonly mutated in ccRCC, and our growing knowledge of the cellular processes that are impacted by them. Furthermore, we explore new avenues for developing therapeutic approaches based on our knowledge of epigenome aberrations of ccRCC. PMID:28812986

Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma.

PubMed

Mehdi, Ali; Riazalhosseini, Yasser

2017-08-16

Clear cell renal cell carcinoma (ccRCC), the most common form of Kidney cancer, is characterized by frequent mutations of the von Hippel-Lindau ( VHL ) tumor suppressor gene in ~85% of sporadic cases. Loss of pVHL function affects multiple cellular processes, among which the activation of hypoxia inducible factor (HIF) pathway is the best-known function. Constitutive activation of HIF signaling in turn activates hundreds of genes involved in numerous oncogenic pathways, which contribute to the development or progression of ccRCC. Although VHL mutations are considered as drivers of ccRCC, they are not sufficient to cause the disease. Recent genome-wide sequencing studies of ccRCC have revealed that mutations of genes coding for epigenome modifiers and chromatin remodelers, including PBRM1 , SETD2 and BAP1 , are the most common somatic genetic abnormalities after VHL mutations in these tumors. Moreover, recent research has shed light on the extent of abnormal epigenome alterations in ccRCC tumors, including aberrant DNA methylation patterns, abnormal histone modifications and deregulated expression of non-coding RNAs. In this review, we discuss the epigenetic modifiers that are commonly mutated in ccRCC, and our growing knowledge of the cellular processes that are impacted by them. Furthermore, we explore new avenues for developing therapeutic approaches based on our knowledge of epigenome aberrations of ccRCC.

Unimolecular thermal decomposition of phenol and d5-phenol: Direct observation of cyclopentadiene formation via cyclohexadienone

NASA Astrophysics Data System (ADS)

Scheer, Adam M.; Mukarakate, Calvin; Robichaud, David J.; Nimlos, Mark R.; Carstensen, Hans-Heinrich; Barney Ellison, G.

2012-01-01

The pyrolyses of phenol and d5-phenol (C6H5OH and C6D5OH) have been studied using a high temperature, microtubular (μtubular) SiC reactor. Product detection is via both photon ionization (10.487 eV) time-of-flight mass spectrometry and matrix isolation infrared spectroscopy. Gas exiting the heated reactor (375 K-1575 K) is subject to a free expansion after a residence time in the μtubular reactor of approximately 50-100 μs. The expansion from the reactor into vacuum rapidly cools the gas mixture and allows the detection of radicals and other highly reactive intermediates. We find that the initial decomposition steps at the onset of phenol pyrolysis are enol/keto tautomerization to form cyclohexadienone followed by decarbonylation to produce cyclopentadiene; C6H5OH → c-C6H6 = O → c-C5H6 + CO. The cyclopentadiene loses a H atom to generate the cyclopentadienyl radical which further decomposes to acetylene and propargyl radical; c-C5H6 → c-C5H5 + H → HC≡CH + HCCCH2. At higher temperatures, hydrogen loss from the PhO-H group to form phenoxy radical followed by CO ejection to generate the cyclopentadienyl radical likely contributes to the product distribution; C6H5O-H → C6H5O + H → c-C5H5 + CO. The direct decarbonylation reaction remains an important channel in the thermal decomposition mechanisms of the dihydroxybenzenes. Both catechol (o-HO-C6H4-OH) and hydroquinone (p-HO-C6H4-OH) are shown to undergo decarbonylation at the onset of pyrolysis to form hydroxycyclopentadiene. In the case of catechol, we observe that water loss is also an important decomposition channel at the onset of pyrolysis.

Inherited Congenital Cataract: A Guide to Suspect the Genetic Etiology in the Cataract Genesis

PubMed Central

Messina-Baas, Olga; Cuevas-Covarrubias, Sergio A.

2017-01-01

Cataracts are the principal cause of treatable blindness worldwide. Inherited congenital cataract (CC) shows all types of inheritance patterns in a syndromic and nonsyndromic form. There are more than 100 genes associated with cataract with a predominance of autosomal dominant inheritance. A cataract is defined as an opacity of the lens producing a variation of the refractive index of the lens. This variation derives from modifications in the lens structure resulting in light scattering, frequently a consequence of a significant concentration of high-molecular-weight protein aggregates. The aim of this review is to introduce a guide to identify the gene involved in inherited CC. Due to the manifold clinical and genetic heterogeneity, we discarded the cataract phenotype as a cardinal sign; a 4-group classification with the genes implicated in inherited CC is proposed. We consider that this classification will assist in identifying the probable gene involved in inherited CC. PMID:28611546

Modification of carbon composites by nanoceramic compounds

NASA Astrophysics Data System (ADS)

Stoch, A.; Jastrzebski, W.; Długoń, E.; Stoch, G. J.; Błażewicz, S.; Adamczyk, A.; Tatarzyńska, K.

2005-06-01

Carbon-carbon composites (C/C) exhibit excellent high-temperature mechanical properties but their air oxidation limits their use at temperatures above 500 °C to inert atmosphere. Variety of coatings has been used to protect C/C composites from oxidation. In this work C/C composite substrates were covered with ceramic multilayer coats by electrophoretic deposition from ceramic sols such as silica sol, alumina sol and silica-lumina sol. Sol particles were of nano-sized dimensions. Deposited coats were annealed at 900-1500 °C. Oxidation tests at 600 °C reveal that the best protection of C/C composite against oxidation gives the multilayer coat formed by three or four electrophoretic depositions. The phase composition in the final annealed layers was analyzed by Infrared spectroscopy (FTIR) and by X-ray diffraction analysis (XRD). Morphology and chemical composition was observed using Scanning electron microscopy (SEM) with energy dispersive X-ray microanalysis (EDS).

Aliphatic C-C Bond Cleavage in α-Hydroxy Ketones by a Dioxygen-Derived Nucleophilic Iron-Oxygen Oxidant.

PubMed

Bhattacharya, Shrabanti; Rahaman, Rubina; Chatterjee, Sayanti; Paine, Tapan K

2017-03-17

A nucleophilic iron-oxygen oxidant, formed in situ in the reaction between an iron(II)-benzilate complex and O 2 , oxidatively cleaves the aliphatic C-C bonds of α-hydroxy ketones. In the cleavage reaction, α-hydroxy ketones without any α-C-H bond afford a 1:1 mixture of carboxylic acid and ketone. Isotope labeling studies established that one of the oxygen atoms from dioxygen is incorporated into the carboxylic acid product. Furthermore, the iron(II) complex cleaves an aliphatic C-C bond of 17-α-hydroxyprogesterone affording androstenedione and acetic acid. The O 2 -dependent aliphatic C-C bond cleavage of α-hydroxy ketones containing no α-C-H bond bears similarity to the lyase activity of the heme enzyme, cytochrome P450 17A1 (CYP17A1). © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Boron-Based Catalysts for C-C Bond-Formation Reactions.

PubMed

Rao, Bin; Kinjo, Rei

2018-05-02

Because the construction of the C-C bond is one of the most significant reactions in organic chemistry, the development of an efficient strategy has attracted much attention throughout the synthetic community. Among various protocols to form C-C bonds, organoboron compounds are not just limited to stoichiometric reagents, but have also made great achievements as catalysts because of the easy modification of the electronic and steric impacts on the boron center. This review presents recent developments of boron-based catalysts applied in the field of C-C bond-formation reactions, which are classified into four kinds on the basis of the type of boron catalyst: 1) highly Lewis acidic borane, B(C 6 F 5 ) 3 ; 2) organoboron acids, RB(OH) 2 , and their ester derivatives; 3) borenium ions, (R 2 BL)X; and 4) other miscellaneous kinds. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Hydroxypropyl-β-cyclodextrin functionalized calcium carbonate microparticles as a potential carrier for enhancing oral delivery of water-insoluble drugs

PubMed Central

Zhang, Lihua; Zhu, Wufu; Lin, Qisi; Han, Jin; Jiang, Liqun; Zhang, Yanzhuo

2015-01-01

The objective of the present study was to demonstrate that a novel hydroxypropyl-β-cyclodextrin functionalized calcium carbonate (HP-β-CD/CC) based amorphous solid dispersion (ASD) can be used to increase the solubility and oral bioavailability of water-insoluble drugs. Irbesartan (IRB) was selected as a model compound and loaded into the nanoporous HP-β-CD/CC matrix using an immersion method. The IRB-loaded HP-β-CD/CC formulation was characterized by various analytical techniques, such as specific surface area analysis, scanning electron microscopy (SEM), dynamic light scattering (DLS), powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC). Analyses with PXRD and DSC confirmed that IRB was fully converted into the amorphous form in the nanopores of HP-β-CD/CC. From the solubility and dissolution tests, it was observed that the aqueous solubility and dissolution rate of IRB-loaded HP-β-CD/CC were increased significantly compared with those of pure IRB and IRB-loaded mesoporous silica. Likewise, the IRB-loaded HP-β-CD/CC formulation exhibited better absorption compared with that of the commercially available IRB capsules in beagle dogs. The mean peak plasma concentration (Cmax) and the area under the mean plasma concentration–time curve (AUC[0→48]) of IRB-loaded HP-β-CD/CC were 1.56- and 1.52-fold higher than that of the commercial product, respectively. Furthermore, the IRB-loaded HP-β-CD/CC formulation exhibited excellent stability against re-crystallization. These results clearly demonstrate that HP-β-CD/CC based porous ASD is a promising formulation approach to improve the aqueous solubility and the in vivo absorption performance of a water-insoluble compound like IRB. PMID:25995635

Hydroxypropyl-β-cyclodextrin functionalized calcium carbonate microparticles as a potential carrier for enhancing oral delivery of water-insoluble drugs.

PubMed

Zhang, Lihua; Zhu, Wufu; Lin, Qisi; Han, Jin; Jiang, Liqun; Zhang, Yanzhuo

2015-01-01

The objective of the present study was to demonstrate that a novel hydroxypropyl-β-cyclodextrin functionalized calcium carbonate (HP-β-CD/CC) based amorphous solid dispersion (ASD) can be used to increase the solubility and oral bioavailability of water-insoluble drugs. Irbesartan (IRB) was selected as a model compound and loaded into the nanoporous HP-β-CD/CC matrix using an immersion method. The IRB-loaded HP-β-CD/CC formulation was characterized by various analytical techniques, such as specific surface area analysis, scanning electron microscopy (SEM), dynamic light scattering (DLS), powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC). Analyses with PXRD and DSC confirmed that IRB was fully converted into the amorphous form in the nanopores of HP-β-CD/CC. From the solubility and dissolution tests, it was observed that the aqueous solubility and dissolution rate of IRB-loaded HP-β-CD/CC were increased significantly compared with those of pure IRB and IRB-loaded mesoporous silica. Likewise, the IRB-loaded HP-β-CD/CC formulation exhibited better absorption compared with that of the commercially available IRB capsules in beagle dogs. The mean peak plasma concentration (C max) and the area under the mean plasma concentration-time curve (AUC[0→48]) of IRB-loaded HP-β-CD/CC were 1.56- and 1.52-fold higher than that of the commercial product, respectively. Furthermore, the IRB-loaded HP-β-CD/CC formulation exhibited excellent stability against re-crystallization. These results clearly demonstrate that HP-β-CD/CC based porous ASD is a promising formulation approach to improve the aqueous solubility and the in vivo absorption performance of a water-insoluble compound like IRB.

Calculation of excitation energies from the CC2 linear response theory using Cholesky decomposition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baudin, Pablo, E-mail: baudin.pablo@gmail.com; qLEAP – Center for Theoretical Chemistry, Department of Chemistry, Aarhus University, Langelandsgade 140, DK-8000 Aarhus C; Marín, José Sánchez

2014-03-14

A new implementation of the approximate coupled cluster singles and doubles CC2 linear response model is reported. It employs a Cholesky decomposition of the two-electron integrals that significantly reduces the computational cost and the storage requirements of the method compared to standard implementations. Our algorithm also exploits a partitioning form of the CC2 equations which reduces the dimension of the problem and avoids the storage of doubles amplitudes. We present calculation of excitation energies of benzene using a hierarchy of basis sets and compare the results with conventional CC2 calculations. The reduction of the scaling is evaluated as well asmore » the effect of the Cholesky decomposition parameter on the quality of the results. The new algorithm is used to perform an extrapolation to complete basis set investigation on the spectroscopically interesting benzylallene conformers. A set of calculations on medium-sized molecules is carried out to check the dependence of the accuracy of the results on the decomposition thresholds. Moreover, CC2 singlet excitation energies of the free base porphin are also presented.« less

Isolation and genetic mapping of a Coffea canephora phenylalanine ammonia-lyase gene (CcPAL1) and its involvement in the accumulation of caffeoyl quinic acids.

PubMed

Mahesh, Venkataramaiah; Rakotomalala, Jean Jacques; Le Gal, Lénaïg; Vigne, Hélène; de Kochko, Alexandre; Hamon, Serge; Noirot, Michel; Campa, Claudine

2006-09-01

Biosynthesis of caffeoylquinic acids occurs via the phenylpropanoid pathway in which the phenylalanine ammonia-lyase (PAL) acts as a key-control enzyme. A full-length cDNA (pF6), corresponding to a PAL gene (CcPAL1), was isolated by screening a Coffea canephora fruit cDNA library and its corresponding genomic sequence was characterized. Amplification of total DNA from seven Coffea species revealed differences in intronic length. This interspecific polymorphism was used to locate the gene on a genetic map established for a backcross progeny between Coffea pseudozanguebariae and C. dewevrei. The CcPAL1 gene was found on the same linkage group, but genetically independent, as a caffeoyl-coenzyme A-O-methyltransferase gene, another gene intervening in the phenylpropanoid pathway. In the same backcross, a lower caffeoylquinic acid content was observed in seeds harvested from plants harbouring the C. pseudozanguebariae CcPAL1 allele. Involvement of the CcPAL1 allelic form in the differential accumulation of caffeoylquinic acids in coffee green beans is then discussed.

Ablation properties of carbon/carbon composites with tungsten carbide

NASA Astrophysics Data System (ADS)

Yin, Jian; Zhang, Hongbo; Xiong, Xiang; Huang, Baiyun; Zuo, Jinlv

2009-02-01

The ablation properties and morphologies of carbon/carbon (C/C) composites with tungsten carbide (WC) filaments were investigated by ablation test on an arc heater and scanning electron microscopy. And the results were compared with those without tungsten carbide (WC) filaments tested under the same conditions. It shows that there is a big difference between C/C composites with and without WC filaments on both macroscopic and microscopic ablation morphologies and the ablation rates of the former are higher than the latter. It is found that the ablation process of C/C composites with WC filaments includes oxidation of carbon fibers, carbon matrices and WC, melting of WC and WO 3, and denudation of WC, WO 3 and C/C composites. Oxidation and melting of WC leads to the formation of holes in z directional carbon fiber bundles, which increases the coarseness of the ablation surfaces of the composites, speeds up ablation and leads to the higher ablation rate. Moreover, it is further found that the molten WC and WO 3 cannot form a continuous film on the ablation surface to prevent further ablation of C/C composites.

Monitoring of Microbial Contaminants of Beef, Pork, and Chicken in HACCP Implemented Meat Processing Plants of Korea.

PubMed

Kim, Jung Hyun; Hur, Sun Jin; Yim, Dong Gyun

2018-04-01

This research was to evaluate microbial contamination levels in meat samples at hazard analysis critical control point (HACCP)-implemented processing plants that produce beef, pork, and chicken. During a period of about a year, a total of 178 samples (76 from beef, 89 from pork, and 13 from chicken) were obtained from raw materials (21.3%) and final products (78.7%). All samples were determined for each 25 g homogenized one. Samples were analyzed to determine the total aerobic plate count (APC), coliform count (CC), and E. coli count (ECC). By month, APC levels were the highest in September and the lowest in February ( p <0.001). In comparison among season, APC levels in meat samples were the highest in the summer and the lowest in winter ( p <0.001). By month, the highest CC prevalence was found in August, followed by October and then July ( p <0.001). By season, the highest CC was obtained in summer, followed by autumn and then spring ( p <0.001). All samples were negative for ECC. There was a direct correlation between the product form and coliform presence ( p <0.001). In addition, there was a positive correlation between the APC and CC (r=0.261). The APCs in analyzed samples ranged from below <10 1 CFU/g to <10 7 CFU/g. In conclusion, the month and season had significant effects on microbial contamination levels at HACCP implemented processing plants. Interrelationships between (i) the product form and coliform, (ii) the APC and CC were revealed.

Catalytic activation of carbon-carbon bonds in cyclopentanones.

PubMed

Xia, Ying; Lu, Gang; Liu, Peng; Dong, Guangbin

2016-11-24

In the chemical industry, molecules of interest are based primarily on carbon skeletons. When synthesizing such molecules, the activation of carbon-carbon single bonds (C-C bonds) in simple substrates is strategically important: it offers a way of disconnecting such inert bonds, forming more active linkages (for example, between carbon and a transition metal) and eventually producing more versatile scaffolds. The challenge in achieving such activation is the kinetic inertness of C-C bonds and the relative weakness of newly formed carbon-metal bonds. The most common tactic starts with a three- or four-membered carbon-ring system, in which strain release provides a crucial thermodynamic driving force. However, broadly useful methods that are based on catalytic activation of unstrained C-C bonds have proven elusive, because the cleavage process is much less energetically favourable. Here we report a general approach to the catalytic activation of C-C bonds in simple cyclopentanones and some cyclohexanones. The key to our success is the combination of a rhodium pre-catalyst, an N-heterocyclic carbene ligand and an amino-pyridine co-catalyst. When an aryl group is present in the C3 position of cyclopentanone, the less strained C-C bond can be activated; this is followed by activation of a carbon-hydrogen bond in the aryl group, leading to efficient synthesis of functionalized α-tetralones-a common structural motif and versatile building block in organic synthesis. Furthermore, this method can substantially enhance the efficiency of the enantioselective synthesis of some natural products of terpenoids. Density functional theory calculations reveal a mechanism involving an intriguing rhodium-bridged bicyclic intermediate.

20 CFR 10.331 - How and when should the medical report be submitted?

Code of Federal Regulations, 2012 CFR

2012-04-01

... medical report be submitted? (a) Form CA-16 may be used for the initial medical report; Form CA-20 may be used for the initial report and for subsequent reports; and Form CA-20a may be used where continued... employee or the physician. (See also § 10.210.) The employer may request a copy of the report from OWCP...

20 CFR 10.331 - How and when should the medical report be submitted?

Code of Federal Regulations, 2013 CFR

2013-04-01

... medical report be submitted? (a) Form CA-16 may be used for the initial medical report; Form CA-20 may be used for the initial report and for subsequent reports; and Form CA-20a may be used where continued... employee or the physician. (See also § 10.210.) The employer may request a copy of the report from OWCP...

20 CFR 10.331 - How and when should the medical report be submitted?

Code of Federal Regulations, 2014 CFR

2014-04-01

... medical report be submitted? (a) Form CA-16 may be used for the initial medical report; Form CA-20 may be used for the initial report and for subsequent reports; and Form CA-20a may be used where continued... employee or the physician. (See also § 10.210.) The employer may request a copy of the report from OWCP...

30 CFR 218.560 - How do I submit Form MMS-4444?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 218.560 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Service of Official... from MMS. It will also be posted on the MMS Web site. Submit the completed, signed form to the address...

75 FR 35843 - Proposed Extension of Information Collection Request Submitted for Public Comment; Form 5500...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... welfare plans (collectively referred to as employee benefit plans) to file returns or reports annually... DEPARTMENT OF LABOR Employee Benefits Security Administration Proposed Extension of Information Collection Request Submitted for Public Comment; Form 5500, Annual Return/Report of Employee Benefit Plan...

30 CFR 210.158 - What reports must I submit to designate someone to make my royalty payments?

Code of Federal Regulations, 2010 CFR

2010-07-01

...-Oil, Gas, and Geothermal Resources § 210.158 What reports must I submit to designate someone to make... http://www.mrm.mms.gov/ReportingServices/Forms/AFSOil_Gas.htm or request the form from MMS at P.O. Box...

75 FR 38798 - Commission Information Collection Activities (FERC Form No. 580) Request; Submitted for OMB...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

..., Office of the Deputy Chief Information Officer, Federal Energy Regulatory Commission, 888 First Street... Information Collection Activities (FERC Form No. 580) Request; Submitted for OMB Review; Correction June 29... submission of information collection to the Office of Management and Budget for review of information...

14 CFR 47.11 - Evidence of ownership.

Code of Federal Regulations, 2014 CFR

2014-01-01

... submits an Aircraft Registration Application, AC Form 8050-1 under this part must also submit the required... administrator. The Certificate of Aircraft Registration, AC Form 8050-3 is issued to the applicant as executor... certified copy of the order of the court appointing him guardian. The Certificate of Aircraft Registration...

14 CFR 47.11 - Evidence of ownership.

Code of Federal Regulations, 2013 CFR

2013-01-01

... submits an Aircraft Registration Application, AC Form 8050-1 under this part must also submit the required... administrator. The Certificate of Aircraft Registration, AC Form 8050-3 is issued to the applicant as executor... certified copy of the order of the court appointing him guardian. The Certificate of Aircraft Registration...

Grande Ronde Basin Chinook Salmon Captive Brood and Conventional Supplementation Programs, 2001 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carmichael, Richard W.

2003-03-01

Endangered Species Permit Number 1011 (formerly Permit No. 973) authorizes ODFW to take listed spring chinook salmon juveniles from Catherine Creek (CC), Lostine River (LR) and Grande Ronde River (GR) for research and enhancement purposes. Modification 2 of this permit authorizes ODFW to take adults for spawning and the production and release of smolts for the Captive and Conventional broodstock programs. This report satisfies the requirement that an annual report be submitted. Herein we report on activities conducted and provide cursory data analyses for the Grande Ronde spring chinook salmon Captive and Conventional broodstock projects from 1 January-31 December 2001.

Grande Ronde Basin Chinook Salmon Captive Brood and Conventional Supplementation Program, 2000 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carmichael, Richard W.

2003-03-01

Endangered Species Permit Number 1011 (formerly Permit No. 973) authorizes ODFW to take listed spring chinook salmon juveniles from Catherine Creek (CC), Lostine River (LR) and Grande Ronde River (GR) for research and enhancement purposes. Modification 2 of this permit authorizes ODFW to take adults for spawning and the production and release of smolts for the Captive and Conventional broodstock programs. This report satisfies the requirement that an annual report be submitted. Herein we report on activities conducted and provide cursory data analyses for the Grande Ronde spring chinook salmon Captive and Conventional broodstock projects from 1 January-31 December 2000.

Inter-hemispheric Functional Connectivity Changes with Corpus Callosum Morphology in Multiple Sclerosis

PubMed Central

Zito, Giancarlo; Luders, Eileen; Tomasevic, Leo; Lupoi, Domenico; Toga, Arthur W.; Thompson, Paul M.; Rossini, Paolo M.; Filippi, Maria M.; Tecchio, Franca

2014-01-01

Multiple sclerosis (MS) affects myelin sheaths within the central nervous system, concurring to cause brain atrophy and neurodegeneration as well as gradual functional disconnections. To explore early signs of altered connectivity in MS from a structural and functional perspective, the morphology of corpus callosum (CC) was correlated with a dynamic inter-hemispheric connectivity index. Twenty mildly disabled patients affected by a relapsing-remitting (RR) form of MS (EDSS ≤ 3.5) and 15 healthy subjects underwent structural MRI to measure CC thickness over 100 sections and electroencephalography to assess a spectral coherence index between primary regions devoted to hand control, at rest and during an isometric handgrip. In patients, an overall CC atrophy was associated with increased lesion load. A less efficacious inter-hemispheric coherence during movement was associated with CC atrophy in sections interconnecting homologous primary motor areas (anterior mid-body). In healthy controls, less efficacious inter-hemispheric coherence at rest was associated with a thinner CC splenium. Our data suggest that in mildly disabled RR-MS patients a covert impairment may be detected in the correlation between the structural (CC thickness) and functional (inter-hemispheric coherence) measures of homologous networks, whereas these two counterparts do not yet differ individually from controls. PMID:24486438

Biosorption of Cr(VI) by coconut coir: spectroscopic investigation on the reaction mechanism of Cr(VI) with lignocellulosic material.

PubMed

Shen, Ying-Shuian; Wang, Shan-Li; Huang, Shiuh-Tsuen; Tzou, Yu-Min; Huang, Jang-Hung

2010-07-15

In this study, the removal mechanism of Cr(VI) from water by coconut coir (CC) was investigated using X-ray photoelectron spectroscopy (XPS), Cr K-edge X-ray absorption near edge structure (XANES) and FTIR spectroscopy. The results showed that, upon reaction with CC at pH 3, Cr(VI) was reduced to Cr(III), which was either bound to CC or released back into solution. As revealed by the FTIR spectra of CC before and after reacting with Cr(VI), the phenolic methoxyl and hydroxyl groups of lignin in CC are the dominant drivers of Cr(VI) reduction, giving rise to carbonyl and carboxyl groups on CC. These functional groups can subsequently provide binding sites for Cr(III) resulting from Cr(VI) reduction. In conjunction with forming complexes with carbonyl and carboxyl groups, the formation of Cr(III) hydroxide precipitate could also readily occur as revealed by the linear combination fitting of the Cr K-edge XANES spectrum using a set of reference compounds. The phenolic groups in lignin are responsible for initiating Cr(VI) reduction, so lignocellulosic materials containing a higher amount of phenolic groups are expected to be more effective scavengers for removal of Cr(VI) from the environment. 2010 Elsevier B.V. All rights reserved.

Ask a SEER Registrar - SEER Registrars

Cancer.gov

First submit questions to your central registry as required and they will submit them to SEER. Use the form on this page to submit questions to SEER staff about coding cancer cases or SEER's reporting guideline materials. Coding and abstracting answers are on SEER Inquiry System website.

Review: aromatase inhibitors for ovulation induction.

PubMed

Casper, Robert F; Mitwally, Mohamed F M

2006-03-01

For the last 40 yr, the first line of treatment for anovulation in infertile women has been clomiphene citrate (CC). CC is a safe, effective oral agent but is known to have relatively common antiestrogenic endometrial and cervical mucous side effects that could prevent pregnancy in the face of successful ovulation. In addition, there is a significant risk of multiple pregnancy with CC, compared with natural cycles. Because of these problems, we proposed the concept of aromatase inhibition as a new method of ovulation induction that could avoid many of the adverse effects of CC. The objective of this review was to describe the different physiological mechanisms of action for CC and aromatase inhibitors (AIs) and compare studies of efficacy for both agents for ovulation induction. We conducted a systematic review of all the published studies, both controlled and noncontrolled, comparing CC and AI treatment, either alone or in combination with gonadotropins, for ovulation induction or augmentation, identified through the Entrez-PubMed search engine. Because of the recent acceptance of the concept of using AIs for ovulation induction, few controlled studies were identified, and the rest of the studies were pilot or preliminary comparisons. Based on these studies, it appears that AIs are as effective as CC in inducing ovulation, are devoid of any antiestrogenic side effects, result in lower serum estrogen concentrations, and are associated with good pregnancy rates with a lower incidence of multiple pregnancy than CC. When combined with gonadotropins for assisted reproductive technologies, AIs reduce the dose of FSH required for optimal follicle recruitment and improve the response to FSH in poor responders. Preliminary evidence suggests that AIs may replace CC in the future because of similar efficacy with a reduced side effect profile. Although worldwide experience with AIs for ovulation induction is increasing, at present, definitive studies in the form of randomized controlled trials comparing CC with AIs are lacking.

The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes.

PubMed

Naito, Daisuke; Ogata, Takehiro; Hamaoka, Tetsuro; Nakanishi, Naohiko; Miyagawa, Kotaro; Maruyama, Naoki; Kasahara, Takeru; Taniguchi, Takuya; Nishi, Masahiro; Matoba, Satoaki; Ueyama, Tomomi

2015-12-15

Muscle-restricted coiled-coil protein (MURC), also referred to as cavin-4, is a member of the cavin family that works cooperatively with caveolins in caveola formation and function. Cavins are cytoplasmic proteins with coiled-coil domains and form heteromeric complexes, which are recruited to caveolae in cells expressing caveolins. Among caveolins, caveolin-3 (Cav3) is exclusively expressed in muscle cells, similar to MURC/cavin-4. In the heart, Cav3 overexpression contributes to cardiac protection, and its deficiency leads to progressive cardiomyopathy. Mutations in the MURC/cavin-4 gene have been identified in patients with dilated cardiomyopathy. In the present study, we show the role of MURC/cavin-4 as a caveolar component in the heart. In H9c2 cells, MURC/cavin-4 was localized at the plasma membrane, whereas a MURC/cavin-4 mutant lacking the coiled-coil domain (ΔCC) was primarily localized to the cytoplasm. ΔCC bound to Cav3 and impaired membrane localization of Cav3 in cardiomyocytes. Additionally, although ΔCC did not alter Cav3 mRNA expression, ΔCC decreased the Cav3 protein level. MURC/cavin-4 and ΔCC similarly induced cardiomyocyte hypertrophy; however, ΔCC showed higher hypertrophy-related fetal gene expression than MURC/cavin-4. ΔCC induced ERK activation in cardiomyocytes. Transgenic mice expressing ΔCC in the heart (ΔCC-Tg mice) showed impaired cardiac function accompanied by cardiomyocyte hypertrophy and marked interstitial fibrosis. Hearts from ΔCC-Tg mice showed a reduction of the Cav3 protein level and activation of ERK. These results suggest that MURC/cavin-4 requires its coiled-coil domain to target the plasma membrane and to stabilize Cav3 at the plasma membrane of cardiomyocytes and that MURC/cavin-4 functions as a crucial caveolar component to regulate cardiac function. Copyright © 2015 the American Physiological Society.

High density hexagonal boron nitride prepared by hot isostatic pressing in refractory metal containers

DOEpatents

Hoenig, Clarence L.

1992-01-01

Boron nitride powder with less than or equal to the oxygen content of starting powder (down to 0.5% or less) is hot isostatically pressed in a refractory metal container to produce hexagonal boron nitride with a bulk density greater than 2.0 g/cc. The refractory metal container is formed of tantalum, niobium, tungsten, molybdenum or alloys thereof in the form of a canister or alternatively plasma sprayed or chemical vapor deposited onto a powder compact. Hot isostatic pressing at 1800.degree. C. and 30 KSI (206.8 MPa) argon pressure for four hours produces a bulk density of 2.21 g/cc. Complex shapes can be made.

40 CFR 60.1385 - What reports must I submit after I submit my notice of construction and in what form?

Code of Federal Regulations, 2014 CFR

2014-07-01

... SOURCES Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is... may submit electronic reports. (c) Keep a copy of all reports required by §§ 60.1400, 60.1410, and 60...

40 CFR 60.1385 - What reports must I submit after I submit my notice of construction and in what form?

Code of Federal Regulations, 2011 CFR

2011-07-01

... SOURCES Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is... may submit electronic reports. (c) Keep a copy of all reports required by §§ 60.1400, 60.1410, and 60...

40 CFR 60.1385 - What reports must I submit after I submit my notice of construction and in what form?

Code of Federal Regulations, 2012 CFR

2012-07-01

... SOURCES Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is... may submit electronic reports. (c) Keep a copy of all reports required by §§ 60.1400, 60.1410, and 60...

40 CFR 60.1385 - What reports must I submit after I submit my notice of construction and in what form?

Code of Federal Regulations, 2010 CFR

2010-07-01

... SOURCES Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is... may submit electronic reports. (c) Keep a copy of all reports required by §§ 60.1400, 60.1410, and 60...

40 CFR 60.1385 - What reports must I submit after I submit my notice of construction and in what form?

Code of Federal Regulations, 2013 CFR

2013-07-01

... SOURCES Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is... may submit electronic reports. (c) Keep a copy of all reports required by §§ 60.1400, 60.1410, and 60...

77 FR 51833 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... required to submit reports of employee service and compensation to the RRB as needed for administering the... employees hired within the last year (new-hires). Form BA-6a, Form BA-6 Address Report, is used by the RRB... also serves as an instruction sheet to railroad employers who can submit the information electronically...

30 CFR 210.155 - What reports must I submit for Federal onshore stripper oil properties?

Code of Federal Regulations, 2010 CFR

2010-07-01

... stripper oil properties? 210.155 Section 210.155 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT FORMS AND REPORTS Special-Purpose Forms and Reports-Oil, Gas, and Geothermal Resources § 210.155 What reports must I submit for Federal onshore stripper oil...

Advances in Planetary Geology

NASA Technical Reports Server (NTRS)

Woronow, A. (Editor)

1982-01-01

Advances in Planetary Geology is a new series intended to serve the planetary geology community with a form for quick and thorough communications. There are no set lists of acceptable topics or formats, and submitted manuscripts will not undergo a formal review. All submissions should be in a camera ready form, preferably spaced, and submitted to the editor.

47 CFR 1.1158 - Form of payment for regulatory fees.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Commission or by Visa, Mastercard, American Express or Discover credit cards only. The Commission discourages... submitted with an application in the wireless radio service) made by credit card or money order must be submitted with a completed FCC Form 159. Failure to accurately enter the credit card number and date of...

7 CFR 331.16 - Transfers.

Code of Federal Regulations, 2011 CFR

2011-01-01

... or CDC prior to the transfer. 8 8 The requirements of this section do not apply to transfers within a... authorization for a transfer, APHIS/CDC Form 2 must be submitted. (e) The recipient must submit a completed APHIS/CDC Form 2 within 2 business days of receipt of a select agent or toxin. (f) The recipient must...

7 CFR 331.16 - Transfers.

Code of Federal Regulations, 2010 CFR

2010-01-01

... or CDC prior to the transfer. 8 8 The requirements of this section do not apply to transfers within a... authorization for a transfer, APHIS/CDC Form 2 must be submitted. (e) The recipient must submit a completed APHIS/CDC Form 2 within 2 business days of receipt of a select agent or toxin. (f) The recipient must...

7 CFR 331.16 - Transfers.

Code of Federal Regulations, 2012 CFR

2012-01-01

... or CDC prior to the transfer. 8 8 The requirements of this section do not apply to transfers within a... authorization for a transfer, APHIS/CDC Form 2 must be submitted. (e) The recipient must submit a completed APHIS/CDC Form 2 within 2 business days of receipt of a select agent or toxin. (f) The recipient must...

29 CFR 1960.72 - Reporting Federal Agency Injury and Illness Information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 9 2014-07-01 2014-07-01 false Reporting Federal Agency Injury and Illness Information... Federal Agency Injury and Illness Information. (a) Each agency must submit to the Secretary by May 1 of... illness recordkeeping forms. The information submitted must include all data entered on the OSHA Form 300...

76 FR 52026 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-19

... AA-104, Application for Canadian Hospital Benefits Under Medicare--Part A, is provided by the RRB to...) submitted: AA-104 Type of request: Revision of a currently approved collection Affected public: Individuals... proposes non-burden impacting formatting and editorial changes to Form AA-104. The burden estimate for the...

Revisit the landscape of protonated water clusters H+(H2O)n with n = 10-17: An ab initio global search.

PubMed

Shi, Ruili; Li, Keyao; Su, Yan; Tang, Lingli; Huang, Xiaoming; Sai, Linwei; Zhao, Jijun

2018-05-07

Using a genetic algorithm incorporated with density functional theory, we explore the ground state structures of protonated water clusters H + (H 2 O) n with n = 10-17. Then we re-optimize the isomers at B97-D/aug-cc-pVDZ level of theory. The extra proton connects with a H 2 O molecule to form a H 3 O + ion in all H + (H 2 O) 10-17 clusters. The lowest-energy structures adopt a monocage form at n = 10-16 and core-shell structure at n = 17 based on the MP2/aug-cc-pVTZ//B97-D/aug-cc-pVDZ+ZPE single-point-energy calculation. Using second-order vibrational perturbation theory, we further calculate the infrared spectra with anharmonic correction for the ground state structures of H + (H 2 O) 10-17 clusters at the PBE0/aug-cc-pVDZ level. The anharmonic correction to the spectra is crucial since it reproduces the experimental results quite well. The extra proton weakens the O-H bond strength in the H 3 O + ion since the Wiberg bond order of the O-H bond in the H 3 O + ion is smaller than that in H 2 O molecules, which causes a red shift of the O-H stretching mode in the H 3 O + ion.

Revisit the landscape of protonated water clusters H+(H2O)n with n = 10-17: An ab initio global search

NASA Astrophysics Data System (ADS)

Shi, Ruili; Li, Keyao; Su, Yan; Tang, Lingli; Huang, Xiaoming; Sai, Linwei; Zhao, Jijun

2018-05-01

Using a genetic algorithm incorporated with density functional theory, we explore the ground state structures of protonated water clusters H+(H2O)n with n = 10-17. Then we re-optimize the isomers at B97-D/aug-cc-pVDZ level of theory. The extra proton connects with a H2O molecule to form a H3O+ ion in all H+(H2O)10-17 clusters. The lowest-energy structures adopt a monocage form at n = 10-16 and core-shell structure at n = 17 based on the MP2/aug-cc-pVTZ//B97-D/aug-cc-pVDZ+ZPE single-point-energy calculation. Using second-order vibrational perturbation theory, we further calculate the infrared spectra with anharmonic correction for the ground state structures of H+(H2O)10-17 clusters at the PBE0/aug-cc-pVDZ level. The anharmonic correction to the spectra is crucial since it reproduces the experimental results quite well. The extra proton weakens the O-H bond strength in the H3O+ ion since the Wiberg bond order of the O-H bond in the H3O+ ion is smaller than that in H2O molecules, which causes a red shift of the O-H stretching mode in the H3O+ ion.

78 FR 75342 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request; NESHAP...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-11

... Request Submitted to OMB for Review and Approval; Comment Request; NESHAP for Lime Manufacturing (Renewal... Agency has submitted an information collection request (ICR), ``NESHAP for Lime Manufacturing (40 CFR... required semiannually. Form Numbers: None. Respondents/affected entities: Lime manufacturing plants...

30 CFR 210.51 - Who must submit royalty reports?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who must submit royalty reports? 210.51 Section 210.51 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT FORMS AND REPORTS Royalty Reports-Oil, Gas, and Geothermal Resources § 210.51 Who must submit...

78 FR 52190 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request; NESHAP...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-22

... Submitted to OMB for Review and Approval; Comment Request; NESHAP for Gasoline Distribution Facilities... Protection Agency has submitted an information collection request (ICR), ``NESHAP for Gasoline Distribution... semiannually at a minimum. Form Numbers: None. Respondents/affected entities: Owners or operators of gasoline...

30 CFR 210.204 - How do I submit facility data?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 210.204 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT FORMS AND REPORTS Production and Royalty Reports-Solid Minerals § 210.204 How do I submit facility...) Output quality or product grades. (5) Your submitted facility data may be internally generated documents...

40 CFR 167.90 - Where to obtain and submit forms.

Code of Federal Regulations, 2010 CFR

2010-07-01

... establishments not found at the same location as their company headquarters, must submit applications and reports... establishments not found at the same location as their company headquarters to be submitted by the company headquarters to the Regional Office having jurisdiction over the State in which the company headquarters is...

21 CFR 720.7 - Notification of person submitting cosmetic product ingredient statement.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Notification of person submitting cosmetic product... AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.7 Notification of person submitting cosmetic product ingredient statement. When Form FDA...

21 CFR 720.7 - Notification of person submitting cosmetic product ingredient statement.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Notification of person submitting cosmetic product... AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.7 Notification of person submitting cosmetic product ingredient statement. When Form FDA...

21 CFR 720.7 - Notification of person submitting cosmetic product ingredient statement.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Notification of person submitting cosmetic product... AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.7 Notification of person submitting cosmetic product ingredient statement. When Form FDA...

21 CFR 720.7 - Notification of person submitting cosmetic product ingredient statement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Notification of person submitting cosmetic product... AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.7 Notification of person submitting cosmetic product ingredient statement. When Form FDA...

21 CFR 720.7 - Notification of person submitting cosmetic product ingredient statement.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Notification of person submitting cosmetic product... AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.7 Notification of person submitting cosmetic product ingredient statement. When Form FDA...

The Peru Cervical Cancer Screening Study (PERCAPS): The Design and Implementation of a Mother/Daughter Screen, Treat, and Vaccinate Program in the Peruvian Jungle

PubMed Central

Levinson, Kimberly L.; Salmeron, Jorge; Sologuren, Carlos Vallejos; Fernandez, Maria Jose Vallejos; Belinson, Jerome L.

2014-01-01

Peru struggles to prevent cervical cancer (CC). In the jungle, prevention programs suffer from significant barriers although technology exists to detect CC precursors. This study used community based participatory research (CBPR) methods to overcome barriers. The objective was to evaluate the utility of CBPR techniques in a mother–child screen/treat and vaccinate program for CC prevention in the Peruvian jungle. The CC prevention program used self-sampling for human papillomavirus (HPV) for screening, cryotherapy for treatment and the HPV vaccine Gardasil for vaccination. Community health leaders (HL) from around Iquitos participated in a two half day educational course. The HLs then decided how to implement interventions in their villages or urban sectors. The success of the program was measured by: (1) ability of the HLs to determine an implementation plan, (2) proper use of research forms, (3) participation and retention rates, and (4) participants’ satisfaction. HLs successfully registered 320 women at soup kitchens, schools, and health posts. Screening, treatment, and vaccination were successfully carried out using forms for registration, consent, and results with minimum error. In the screen/treat intervention 100 % of participants gave an HPV sample and 99.7 % reported high satisfaction; 81 % of HPV + women were treated, and 57 % returned for 6-month followup. Vaccine intervention: 98 % of girls received the 1st vaccine, 88 % of those received the 2nd, and 65 % the 3rd. CBPR techniques successfully helped implement a screen/treat and vaccinate CC prevention program around Iquitos, Peru. These techniques may be appropriate for large-scale preventive health-care interventions. PMID:24276617

The Peru Cervical Cancer Screening Study (PERCAPS): the design and implementation of a mother/daughter screen, treat, and vaccinate program in the Peruvian jungle.

PubMed

Abuelo, Carolina E; Levinson, Kimberly L; Salmeron, Jorge; Sologuren, Carlos Vallejos; Fernandez, Maria Jose Vallejos; Belinson, Jerome L

2014-06-01

Peru struggles to prevent cervical cancer (CC). In the jungle, prevention programs suffer from significant barriers although technology exists to detect CC precursors. This study used community based participatory research (CBPR) methods to overcome barriers. The objective was to evaluate the utility of CBPR techniques in a mother-child screen/treat and vaccinate program for CC prevention in the Peruvian jungle. The CC prevention program used self-sampling for human papillomavirus (HPV) for screening, cryotherapy for treatment and the HPV vaccine Gardasil for vaccination. Community health leaders (HL) from around Iquitos participated in a two half day educational course. The HLs then decided how to implement interventions in their villages or urban sectors. The success of the program was measured by: (1) ability of the HLs to determine an implementation plan, (2) proper use of research forms, (3) participation and retention rates, and (4) participants' satisfaction. HLs successfully registered 320 women at soup kitchens, schools, and health posts. Screening, treatment, and vaccination were successfully carried out using forms for registration, consent, and results with minimum error. In the screen/treat intervention 100% of participants gave an HPV sample and 99.7% reported high satisfaction; 81% of HPV + women were treated, and 57% returned for 6-month followup. Vaccine intervention: 98% of girls received the 1st vaccine, 88% of those received the 2nd, and 65% the 3rd. CBPR techniques successfully helped implement a screen/treat and vaccinate CC prevention program around Iquitos, Peru. These techniques may be appropriate for large-scale preventive health-care interventions.

21 CFR 803.53 - If I am a manufacturer, in which circumstances must I submit a 5-day report?

Code of Federal Regulations, 2010 CFR

2010-04-01

... must I submit a 5-day report? 803.53 Section 803.53 Food and Drugs FOOD AND DRUG ADMINISTRATION... Reporting Requirements § 803.53 If I am a manufacturer, in which circumstances must I submit a 5-day report? You must submit a 5-day report to us, on Form 3500A or an electronic equivalent approved under § 803...

21 CFR 803.53 - If I am a manufacturer, in which circumstances must I submit a 5-day report?

Code of Federal Regulations, 2012 CFR

2012-04-01

... must I submit a 5-day report? 803.53 Section 803.53 Food and Drugs FOOD AND DRUG ADMINISTRATION... Reporting Requirements § 803.53 If I am a manufacturer, in which circumstances must I submit a 5-day report? You must submit a 5-day report to us, on Form 3500A or an electronic equivalent approved under § 803...

21 CFR 803.53 - If I am a manufacturer, in which circumstances must I submit a 5-day report?

Code of Federal Regulations, 2013 CFR

2013-04-01

... must I submit a 5-day report? 803.53 Section 803.53 Food and Drugs FOOD AND DRUG ADMINISTRATION... Reporting Requirements § 803.53 If I am a manufacturer, in which circumstances must I submit a 5-day report? You must submit a 5-day report to us, on Form 3500A or an electronic equivalent approved under § 803...

21 CFR 803.53 - If I am a manufacturer, in which circumstances must I submit a 5-day report?

Code of Federal Regulations, 2011 CFR

2011-04-01

... must I submit a 5-day report? 803.53 Section 803.53 Food and Drugs FOOD AND DRUG ADMINISTRATION... Reporting Requirements § 803.53 If I am a manufacturer, in which circumstances must I submit a 5-day report? You must submit a 5-day report to us, on Form 3500A or an electronic equivalent approved under § 803...

Influence of bending of monoatomic copper chains with 10 and 22 atoms on their absorbance spectra: TD-DFT calculations

NASA Astrophysics Data System (ADS)

Markin, Alexey V.; Skaptsov, Alexander A.; Markina, Natalia E.

2018-04-01

The aim of the work is the investigation of bending on the properties of hypothetical one-atom-thick copper clusters (CC) (with 10 and 22 atoms). Time-dependent density functional theory with PBE0 functional and lanl2dz basis set were used for all calculations. The bending was performed by changing angle between copper atoms from 180° to 144° and 163.7° (2° step size) for CC with 10 and 22 atoms, correspondingly. The dependences of absorbance spectra in UVvisible-NIR range (400-2000 nm range) and various energetic characteristics (final energy, chemical potential, and binding energy) on bending angle were investigated. Non-bended (linear) clusters were assigned as references. First, absorbance spectra of all CC contain interband transitions (3d->4sp) in UV-visible range (below 600 nm). Linear configuration of CC also contain intensive absorbance band in NIR region (at 900 and 1700 nm for CC with 10 and 22 atoms) which is associated with 4s electron oscillations along clusters (longitudinal transitions). Significant dumping of low energy 4s transitions (HOMO->LUMO) and interband transitions in the range 600‒500 nm was observed during the bending of CC. Obtained results are in agreement with experimental results for 2D copper nanostructures from literature. We explain such influence of bending by formation merging 4s orbitals which form new 4s oscillations in-plane of bending (in the case of ring-like CC - diametral oscillations). An influence of bending on energy, stability, and chemical potential (Fermi level) of CC was also investigated and discussed.

Electronic Submissions of Pesticide Applications

EPA Pesticide Factsheets

Applications for pesticide registration can be submitted electronically, including forms, studies, and draft product labeling. Applicants need not submit multiple electronic copies of any pieces of their applications.

The Effect of Anatomical Location of Lymph Node Metastases on Cancer Specific Survival in Patients with Clear Cell Renal Cell Carcinoma.

PubMed

Nini, Alessandro; Larcher, Alessandro; Cianflone, Francesco; Trevisani, Francesco; Terrone, Carlo; Volpe, Alessandro; Regis, Federica; Briganti, Alberto; Salonia, Andrea; Montorsi, Francesco; Bertini, Roberto; Capitanio, Umberto

2018-01-01

Positive nodal status (pN1) is an independent predictor of survival in renal cell carcinoma (RCC) patients. However, no study to date has tested whether the location of lymph node (LN) metastases does affect oncologic outcomes in a population submitted to radical nephrectomy (RN) and extended lymph node dissection (eLND). To describe nodal disease dissemination in clear cell RCC (ccRCC) patients and to assess the effect of the anatomical sites and the number of nodal areas affected on cancer specific mortality (CSM). The study included 415 patients who underwent RN and eLND, defined as the removal of hilar, side-specific (pre/paraaortic or pre/paracaval) and interaortocaval LNs for ccRCC, at two institutions. Descriptive statistics were used to depict nodal dissemination in pN1 patients, stratified according to nodal site and number of involved areas. Multivariable Cox regression analyses and Kaplan-Meier curves were used to explore the relationship between pN1 disease features and survival outcomes. Median number of removed LN was 14 (IQR 9-19); 23% of patients were pN1. Among patients with one involved nodal site, 54 and 26% of patients were positive only in side-specific and interaortocaval station, respectively. The most frequent nodal site was the interaortocaval and side-specific one, for right and left ccRCC, respectively. Interaortocaval nodal positivity (HR 2.3, CI 95%: 1.3-3.9, p < 0.01) represented an independent predictor of CSM. When ccRCC patient harbour nodal disease, its spreading can occur at any nodal station without involving the others. The presence of interoartocaval positive nodes does affect oncologic outcomes. Lymph node invasion in patients with clear cell renal cell carcinoma is not following a fixed anatomical pattern. An extended lymph node dissection, during treatment for primary kidney tumour, would aid patient risk stratification and multimodality upfront treatment.

75 FR 65297 - Notice of Public Information Collection Requirements Submitted to OMB for Review

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

.... SUPPLEMENTARY INFORMATION: OMB Number: OMB 0412-New. Form Number: AID 321-1. Title: Mentor Prot[eacute]g[eacute... interested in participating in the U.S. Agency for International Developments (USAID) Mentor-Prot[eacute]g... (OSDBU) by submitting the application form. The application will contain the Mentor- Prot[eacute]g[eacute...

77 FR 39705 - Information Collection(s) Being Submitted for Review and Approval to the Office of Management and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

.... SUPPLEMENTARY INFORMATION: OMB Control Number: 3060-0228. Title: Section 80.59, Compulsory Ship Inspections and Ship Inspection Certificates. Form Numbers: FCC Forms 806, 824, 827 and 829. Type of Review: Revision... States where an inspection can be held. An information application must be submitted by the ship's owner...

75 FR 8366 - Centers for Disease Control and Prevention Proposed Data Collections Submitted for Public Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... in hard copy. Respondent/petitioners should be aware that HHS is not requiring respondents to use the forms. Respondents can choose to submit petitions as letters or in other formats, but petitions must... form, since it provides a simple, organized format for addressing the informational requirements of a...

30 CFR 210.156 - What reports must I submit for net profit share leases?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What reports must I submit for net profit share leases? 210.156 Section 210.156 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT FORMS AND REPORTS Special-Purpose Forms and Reports-Oil, Gas, and Geothermal...

44 CFR 295.10 - Bringing a claim under the CGFAA.

Code of Federal Regulations, 2013 CFR

2013-10-01

... under the CGFAA by filing a Notice of Loss. A claim submitted on any form other than a Notice of Loss..., the signer must disclose his or her relationship to the Claimant. FEMA may require a legal representative to submit evidence of authority. (d) Notice of Loss forms are available from OCGFC by request...

44 CFR 295.10 - Bringing a claim under the CGFAA.

Code of Federal Regulations, 2014 CFR

2014-10-01

... under the CGFAA by filing a Notice of Loss. A claim submitted on any form other than a Notice of Loss..., the signer must disclose his or her relationship to the Claimant. FEMA may require a legal representative to submit evidence of authority. (d) Notice of Loss forms are available from OCGFC by request...

43 CFR 428.4 - Who must submit forms under this part.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., DEPARTMENT OF THE INTERIOR INFORMATION REQUIREMENTS FOR CERTAIN FARM OPERATIONS IN EXCESS OF 960 ACRES AND.... (b) Anyone who is the indirect owner of a legal entity that is a farm operator meeting the criteria... paragraph (a) of this section you need not submit another RRA form during the current water year, even if...

Cooperative structural transitions in amyloid-like aggregation

NASA Astrophysics Data System (ADS)

Steckmann, Timothy; Bhandari, Yuba R.; Chapagain, Prem P.; Gerstman, Bernard S.

2017-04-01

Amyloid fibril aggregation is associated with several horrific diseases such as Alzheimer's, Creutzfeld-Jacob, diabetes, Parkinson's, and others. Although proteins that undergo aggregation vary widely in their primary structure, they all produce a cross-β motif with the proteins in β-strand conformations perpendicular to the fibril axis. The process of amyloid aggregation involves forming myriad different metastable intermediate aggregates. To better understand the molecular basis of the protein structural transitions and aggregation, we report on molecular dynamics (MD) computational studies on the formation of amyloid protofibrillar structures in the small model protein ccβ, which undergoes many of the structural transitions of the larger, naturally occurring amyloid forming proteins. Two different structural transition processes involving hydrogen bonds are observed for aggregation into fibrils: the breaking of intrachain hydrogen bonds to allow β-hairpin proteins to straighten, and the subsequent formation of interchain H-bonds during aggregation into amyloid fibrils. For our MD simulations, we found that the temperature dependence of these two different structural transition processes results in the existence of a temperature window that the ccβ protein experiences during the process of forming protofibrillar structures. This temperature dependence allows us to investigate the dynamics on a molecular level. We report on the thermodynamics and cooperativity of the transformations. The structural transitions that occurred in a specific temperature window for ccβ in our investigations may also occur in other amyloid forming proteins but with biochemical parameters controlling the dynamics rather than temperature.

Novel Aminoglycoside Resistance Transposons and Transposon-Derived Circular Forms Detected in Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates

PubMed Central

Dwibedi, Chinmay Kumar; Sjöström, Karin; Edquist, Petra; Wai, Sun Nyunt; Uhlin, Bernt Eric

2016-01-01

Acinetobacter baumannii has emerged as an important opportunistic pathogen equipped with a growing number of antibiotic resistance genes. Our study investigated the molecular epidemiology and antibiotic resistance features of 28 consecutive carbapenem-resistant clinical isolates of A. baumannii collected throughout Sweden in 2012 and 2013. The isolates mainly belonged to clonal complexes (CCs) with an extensive international distribution, such as CC2 (n = 16) and CC25 (n = 7). Resistance to carbapenems was related to blaOXA-23 (20 isolates), blaOXA-24/40-like (6 isolates), blaOXA-467 (1 isolate), and ISAba1-blaOXA-69 (1 isolate). Ceftazidime resistance was associated with blaPER-7 in the CC25 isolates. Two classical point mutations were responsible for resistance to quinolones in all the isolates. Isolates with high levels of resistance to aminoglycosides carried the 16S rRNA methylase armA gene. The isolates also carried a variety of genes encoding aminoglycoside-modifying enzymes. Several novel structures involved in aminoglycoside resistance were identified, including Tn6279, ΔTn6279, Ab-ST3-aadB, and different assemblies of Tn6020 and TnaphA6. Importantly, a number of circular forms related to the IS26 or ISAba125 composite transposons were detected. The frequent occurrence of these circular forms in the populations of several isolates indicates a potential role of these circular forms in the dissemination of antibiotic resistance genes. PMID:26824943

MR imaging and MR cholangiopancreatography of cholangiocarcinoma developing in printing company workers.

PubMed

Koyama, Koichi; Kubo, Shoji; Ueki, Ai; Shimono, Taro; Takemura, Shigekazu; Tanaka, Shogo; Kinoshita, Masahiko; Hamano, Genya; Miki, Yukio

2017-05-01

To retrospectively investigate magnetic resonance (MR) imaging findings of occupational cholangiocarcinoma (oCC) occurring among workers in printing companies in Japan, compared to those of non-occupational cholangiocarcinoma (nCC), primary sclerosing cholangitis (PSC), and age-matched normal controls (NORs). Participants comprised 27 consecutive patients (oCC, n = 5; nCC, n = 8; PSC, n = 6; NOR, n = 8) who underwent MR imaging between May 2009 and October 2012. MR imaging was evaluated with respect to tumor characteristics, abnormal MR cholangiographic findings (PSC-like findings), bile duct stricture, and signal changes of the hepatic parenchyma. Tumors were detected in all nCCs and four oCCs. Tumors displayed a mass-forming type in all nCCs and two oCCs, and an intraductal growth type in two oCCs. Abnormal cholangiographic findings were detected in all oCCs and PSCs, but not in any nCCs or NORs. All oCCs and seven nCCs showed biliary strictures longer than 1 cm; five PSCs showed biliary strictures shorter than 1 cm. Both intra- and extrahepatic biliary strictures were detected in three PSCs and two oCCs. Peripheral hepatic hyperintensity on T2-weighted imaging was detected in two nCCs, two PSCs, and two oCCs. These results indicated that MR imaging of oCC showed findings of both PSC and nCC.

Method of low pressure and/or evaporative drying of aerogel

DOEpatents

Mayer, Steven T.; Kaschmitter, James L.; Pekala, Richard W.

1995-01-01

A process whereby Resorcinol/Formaldehyde (RF) aerogel having a density of about 0.4-1.2 g/cc can be manufactured using a simple air drying procedure. This process is inherently simpler, quicker, and less expensive than the more conventional supercritical or subcritical CO.sub.2 extraction procedures. RF aerogels can be used as produced, such as in insulation applications, or pyrolyzed to form carbon aerogels with a density of about 0.9 g/cc for use in applications such as batteries, supercapacitors, etc.

Theoretical study of the Diels-Alder reaction between o-benzoquinone and norbornadiene

NASA Astrophysics Data System (ADS)

Quijano-Quiñones, Ramiro F.; Quesadas-Rojas, M.; Cuevas, Gabriel; Mena-Rejón, Gonzalo J.

2013-06-01

The reaction between norbornadiene and o-benzoquinone is an important step in polyalicyclic rigid structures synthesis. It has been considered that this reaction is an example of Diels-Alder (DA) and hetero-Diels-Alder (HDA) cycloadditions with o-benzoquinone acting as diene (forming C-C bonds) and heterodiene (forming O-C bonds). We have performed a Density Functional Theory study of this reaction, employing B3LYP, mPW1PW91, and B1B95 functionals and 6-31G(d,p) and 6-31+G(d,p) Gaussian type basis sets. The results indicate that Diels-Alder is a feasible mechanism for both reactions, but should not be the main route to the formation of products with C-C bonds.

30 CFR 210.101 - Who must submit production reports?

Code of Federal Regulations, 2010 CFR

2010-07-01

... MANAGEMENT FORMS AND REPORTS Production Reports-Oil and Gas § 210.101 Who must submit production reports? (a... operator number. To obtain an operator number, refer to the MMS Minerals Production Reporter Handbook for... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who must submit production reports? 210.101...

30 CFR 210.104 - Must I submit these production reports electronically?

Code of Federal Regulations, 2010 CFR

2010-07-01

... MINERALS REVENUE MANAGEMENT FORMS AND REPORTS Production Reports-Oil and Gas § 210.104 Must I submit these... Production Reporter Handbook for the most current reporting options, instructions, and security measures. The... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Must I submit these production reports...

78 FR 45923 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request; NESHAP...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

... Submitted to OMB for Review and Approval; Comment Request; NESHAP for Automobile and Light-duty Truck... Environmental Protection Agency has submitted an information collection request (ICR), ``NESHAP for Automobile... semiannually at a minimum. Form Numbers: None. Respondents/affected entities: Owners or operators of automobile...

Molecular epidemiology and strain-specific characteristics of Streptococcus agalactiae at the herd and cow level.

PubMed

Mahmmod, Y S; Klaas, I C; Katholm, J; Lutton, M; Zadoks, R N

2015-10-01

Host-adaptation of Streptococcus agalactiae subpopulations has been described whereby strains that are commonly associated with asymptomatic carriage or disease in people differ phenotypically and genotypically from those causing mastitis in dairy cattle. Based on multilocus sequence typing (MLST), the most common strains in dairy herds in Denmark belong to sequence types (ST) that are also frequently found in people. The aim of this study was to describe epidemiological and diagnostic characteristics of such strains in relation to bovine mastitis. Among 1,199 cattle from 6 herds, cow-level prevalence of S. agalactiae was estimated to be 27.4% based on PCR and 7.8% based on bacteriological culture. Quarter-level prevalence was estimated at 2.8% based on bacteriological culture. Per herd, between 2 and 26 isolates were characterized by pulsed-field gel electrophoresis (PFGE) and MLST. Within each herd, a single PFGE type and ST predominated, consistent with a contagious mode of transmission or point source infection within herds. Evidence of within-herd evolution of S. agalactiae was detected with both typing methods, although ST belonged to a single clonal complex (CC) per herd. Detection of CC23 (3 herds) was associated with significantly lower approximate count (colony-forming units) at the quarter level and significantly lower cycle threshold value at the cow level than detection of CC1 (2 herds) or CC19 (1 herd), indicating a lower bacterial load in CC23 infections. Median values for the number of infected quarters and somatic cell count (SCC) were numerically but not significantly lower for cows infected with CC23 than for cows with CC1 or CC19. For all CC, an SCC threshold of 200,000 cells/mL was an unreliable indicator of infection status, and prescreening of animals based on SCC as part of S. agalactiae detection and eradication campaigns should be discouraged. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

21 CFR 803.53 - If I am a manufacturer, in which circumstances must I submit a 5-day report?

Code of Federal Regulations, 2014 CFR

2014-04-01

..., including any trend analysis; or (b) We have made a written request for the submission of a 5-day report. If... must I submit a 5-day report? 803.53 Section 803.53 Food and Drugs FOOD AND DRUG ADMINISTRATION... must I submit a 5-day report? You must submit a 5-day report to us, on Form 3500A or an electronic...

Mammary analogue secretory carcinoma (MASC) of salivary gland in four Mexican patients.

PubMed

Serrano-Arévalo, Mónica L; Mosqueda-Taylor, Adalberto; Domínguez-Malagón, Hugo; Michal, Michal

2015-01-01

The Clinco-pathological, immunohistochemical and molecular findings of four cases of Mammary Analogue Secretory Carcinoma (MASC) of salivary glands found in Mexico are described. The cases were extracted from 253 salivary gland tumors from a single institution in Mexico City. The 85 Candidates for initial selection were: low grade mucoepidermoid carcinoma (MEC) (N=70 ), Acinic cell cancinoma (AciCC) (N=14), papillary cystadenocarcinoma (N=1), and adenocarcinoma NOS (N=0). Tumors with some histological features consistent with MASC (N= 17, 6.7%) were studied by immunohistochemistry for mammaglobin, STAT5, and S-100 protein and four cases were positive (1.5%), thus the diagnosis of MASC was established, and these were submitted for molecular studies for ETV6-NTRK3. Fusion gene was demonstrated in three cases, two had been erroneously diagnosed as poorly granulated AciCC, and one as low grade MEC with microcystic pattern. Female gender predominated (3:1); one occurred in the parotid, two in minor salivary glands and one in the submaxillary gland; infiltrating borders, atypical mitosis and lymph node metastases were seen in the parotideal tumor. Two patients with major salivary gland tumors are alive and well at 10 and 20 months respectively, the two patients with minor salivary gland tumors are lost. It can be concluded that is important to think in MASC in poorly granulated AciCC and low grade MEC with microcystic pattern. Immunohistochemisty studies confirm the diagnosis, preferentially supported by molecular studies. MASC may follow aggressive behavior or transform into a high grade neoplasm.

Novel members of the adipokinetic hormone family in beetles of the superfamily Scarabaeoidea.

PubMed

Gäde, Gerd; Šimek, Petr; Marco, Heather G

2016-12-01

Eight beetle species of the superfamily Scarabaeoidea were investigated with respect to peptides belonging to the adipokinetic hormone (AKH) family in their neurohemal organs, the corpora cardiaca (CC). The following beetle families are represented: Scarabaeidae, Lucanidae, and Geotrupidae. AKH peptides were identified through a heterospecific trehalose-mobilizing bioassay and by sequence analyses, using liquid chromatography coupled to positive electrospray mass spectrometry (LC-ESI-MS) and analysis of the tandem MS 2 spectra obtained by collision-induced dissociation. All the beetle species have octapeptide AKHs; some have two AKHs, while others have only one. Novel AKH members were found in Euoniticellus intermedius and Circellium bacchus (family Scarabaeidae), as well as in Dorcus parallelipipedus (family Lucanidae). Two species of the family Geotrupidae and two species of the Scarabaeidae subfamily Cetoniinae contain one known AKH peptide, Melme-CC, while E. intermedius produces a novel peptide code named Euoin-AKH: pEINFTTGWamide. Two AKH peptides were each identified in CC of C. bacchus and D. parallelipipedus: the novel Cirba-AKH: pEFNFSAGWamide and the known peptide, Scade-CC-I in the former, and the novel Dorpa-AKH: pEVNYSPVW amide and the known peptide, Melme-CC in the latter. Kheper bonelli (subfamily Scarabaeinae) also has two AKHs, the known Scade-CC-I and Scade-CC-II. All the novel peptides were synthesized and the amino acid sequence assignments were unequivocally confirmed by co-elution of the synthetic peptides with their natural equivalent, and identical MS parameters of the two forms. The novel synthetic peptides are all active in inducing hypertrehalosemia in cockroaches.

Endoscopy-coupled Raman spectroscopy for in vivo discrimination of inflammatory bowel disease

NASA Astrophysics Data System (ADS)

Pence, I. J.; Nguyen, Q. T.; Bi, X.; Herline, A. J.; Beaulieu, D. M.; Horst, S. N.; Schwartz, D. A.; Mahadevan-Jansen, A.

2014-03-01

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's colitis (CC), affects nearly 2 million Americans, and the incidence is increasing worldwide. It has been established that UC and CC are distinct forms of IBD and require different medical care, however the distinction made between UC and CC is based upon inexact clinical, radiological, endoscopic, and pathologic features. A diagnosis of indeterminate colitis occurs in up to 15% of patients when UC and CC features overlap and cannot be differentiated; in these patients, diagnosis relies on long term followup, success or failure of existing treatment, and recurrence of the disease. Thus, there is need for a tool that can improve the sensitivity and specificity for fast, accurate and automated diagnosis of IBD. Here we present colonoscopy-coupled fiber probe-based Raman spectroscopy as a novel in vivo diagnostic tool for IBD. This in vivo study of both healthy control (NC, N=10) and diagnosed IBD patients with UC (N=15) and CC (N=26) aims to characterize spectral signatures of NC, UC, and CC. Samples are correlated with tissue pathology markers and endoscopic evaluation. Optimal collection parameters for detection have been identified based upon the new, application specific instrument design. The collected spectra are processed and analyzed using multivariate statistical techniques to identify spectral markers and discriminate NC, UC, and CC. Development of spectral markers to discriminate disease type is a necessary first step in the development of real-time, accurate and automated in vivo detection of IBD during colonoscopy procedures.

Department of the Navy Justification of Estimates for Fiscal Year 1986 Submitted to Congress February 1985, Operation & Maintenance, Navy. Book 3.

DTIC Science & Technology

1985-02-01

Et COMMUNICATIONS, U G ET A T V T :lT A NNlM E I A G ABUDGET ACTIVITY 9: ADMINISTRATION ft ASSOC ACTS BUDGET ACTIVITY 10: SUPPORT TO OTHER NATIONS...85 628 0318 I r- m~ -Cc. Vc MuL ,n aI I I I8 I 8I1I1. ,. C 0’. CD ODC~ V . q* mY 00t M CO Io -~,r- M~ r- en 0 CO -" C%)0 (%.k LL v koO C)O~ 4n C%. ____r...Property 109 f. Base Operations 131 - ~ ~ V .. O&M.N 3 -4 *• ". .’. i

Infrared study of matrix-isolated ethyl cyanide: simulation of the photochemistry in the atmosphere of Titan.

PubMed

Toumi, A; Piétri, N; Couturier-Tamburelli, I

2015-11-11

Low-temperature Ar matrix isolation has been carried out to investigate the infrared spectrum of ethyl cyanide (CH3CH2CN), a molecule present in the atmosphere of Titan. The λ > 120 nm and λ > 230 nm photolysis reactions of ethyl cyanide in an Ar matrix were also performed in order to compare the behaviour of this compound when it is submitted to high and low energetic radiations. These different wavelengths have been used with the aim to reproduce the radiation reaching the various parts of the atmosphere. Several photoproducts have been identified during photolysis such as vinyl cyanide (CH2[double bond, length as m-dash]CHCN), cyanoacetylene (HC3N), and ethylene/hydrogen cyanide (C2H4/HCN), ethylene/hydrogen isocyanide (C2H4/HNC), acetylene/hydrogen cyanide (C2H2/HCN), acetylene/hydrogen isocyanide (C2H2/HNC), and acetylene:methylenimine (C2H2:HNCH2) complexes. Ethyl isocyanide (CH3CH2NC) and a ketenimine form (CH3CH[double bond, length as m-dash]C[double bond, length as m-dash]NH) have been identified as well. Photoproduct identification and spectral assignments were done using previous studies and density functional theory (DFT) calculations with the B3LYP/cc-pVTZ basis set.

26 CFR 1.9101-1 - Permission to submit information required by certain returns and statements on magnetic tape.

Code of Federal Regulations, 2010 CFR

2010-04-01

... submitting the information required by such form on magnetic tape or by other media, provided that the prior... required by such form on magnetic tape or other approved media, provided that the prior consent of the Commissioner of Social Security (or other authorized officer or employee thereof) has been obtained. [T.D. 6883...

A Study of Assessing Errors and Completeness of Research Application Forms Submitted to Instituitional Ethics Committee (IEC) of a Tertiary Care Hospital.

PubMed

Shah, Pruthak C; Panchasara, Ashwin K; Barvaliya, Manish J; Tripathi, C B

2016-09-01

Application form of research work is an essential requirement which is required to be submitted along with the research proposal to the Ethics Committee (EC). To check the completeness and to find the errors in application forms submitted to the EC of a tertiary care hospital. The application forms of research projects submitted to the Institutional Review Board (IRB), Government Medical College, Bhavnagar, Gujarat, India from January 2014 to June 2015 were analysed for completeness and errors, with respect to the following - type of study, information about study investigators, sample size, study participants, title of the studies, signatures of all investigators, regulatory approval, recruitment procedure, compensation to study participants, informed consent process, information about sponsor, declaration of conflict of interest, plans for storage and maintenance of data, patient information sheet, informed consent forms and study related documents. Total 100 application forms were analysed. Among them, 98 were academic and 2 were industrial studies. Majority of academic studies were of basic science type. In 63.26% studies, type of study was not mentioned in title. Age group of subjects was not mentioned in 8.16% application forms. In 34.6% informed consent, benefits of the study were not mentioned. Signature of investigators/co-investigators/Head of the Department was missing in 3.06% cases. Our study recommends that the efficiency and speed of review will increase if investigator will increase vigilance regarding filling of application forms. Regular meetings will be helpful to solve the problems related to content of application forms. The uniformity in functioning of EC can be achieved if common application form for all ECs is there.

Variations in biofilm formation, desiccation resistance and Benzalkonium chloride susceptibility among Listeria monocytogenes strains isolated in Canada.

PubMed

Piercey, Marta J; Ells, Timothy C; Macintosh, Andrew J; Truelstrup Hansen, Lisbeth

2017-09-18

Listeria monocytogenes is a pathogenic foodborne microorganism noted for its ability to survive in the environment and food processing facilities. Survival may be related to the phenotype of individual strains including the ability to form biofilms and resist desiccation and/or sanitizer exposure. The objectives of this research were to compare 14 L. monocytogenes strains isolated from blood (3), food (6) and water (5) with respect to their benzalkonium chloride (BAC) sensitivity, desiccation resistance, and ability to form biofilm. Correlations were tested between those responses, and the presence of the SSI-1 (Stress Survival Islet) and LGI1/CC8 (Listeria Genomic Island 1 in a clonal complex 8 background) genetic markers. Genetic sequences from four strains representing different phenotypes were also probed for predicted amino acid differences in biofilm, desiccation, and membrane related genes. The water isolates were among the most desiccation susceptible strains, while strains exhibiting desiccation resistance harboured SSI-1 or both the SSI-1 and LGI1/CC8 markers. BAC resistance was greatest in planktonic LGI1/CC8 cells (relative to non-LGI1/CC8 cells), and higher BAC concentrations were also needed to inhibit the formation of biofilm by LGI1/CC8 strains during incubation for 48h and 6days compared to other strains. Formation of biofilm on stainless steel was not significantly (p>0.05) different among the strains. Analysis of genetic sequence data from desiccation and BAC sensitive (CP4 5-1, CP5 2-3, both from water), intermediate (Lm568, food) and desiccation and BAC resistant (08 5578, blood, human outbreak) strains led to the finding of amino acid differences in predicted functional protein domains in several biofilm, desiccation and peptidoglycan related genes (e.g., lmo0263, lmo0433, lmo0434, lmo0771, lmo0973, lmo1080, lmo1224, lmo1370, lmo1744, and lmo2558). Notably, the LGI1/CC8 strain 08-5578 had a frameshift mutation in lmo1370, a gene previously associated with desiccation resistance. In conclusion, the more desiccation and BAC resistant LGI1/CC8 isolates may pose a challenge for sanitation efforts. Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.

Presidential Green Chemistry Challenge: 2007 Academic Award

EPA Pesticide Factsheets

Presidential Green Chemistry Challenge 2007 award winner, Professor Michael J. Krische, developed selective C-C bond-forming hydrogenation without organometallic reagents, eliminating hazardous reagents and hazardous waste.

Information on Receiving Contract and Commercial Payments

EPA Pesticide Factsheets

Provides links to payment instructions and financial forms and reports for vendors and grant recipients. Billing tips, instructions for submitting invoices electronically or by email, including submitting simplified acquisition payments (SAPs).

Aids to Practice.

DTIC Science & Technology

1986-01-01

alone prepared and signed by TC and accused (optional use of written form): Request for enlisted menbers signed by the accused submitted: Pretrial motions...CA: Accepted/rejected by CA: Signed : (Date) If submitted, signed trial by KJ alone request and returned to DC: If submitted, contacted CA about detail...Judge Alone ... ..... 11-104 Motion for a Continuance ..... ................. ... 11-105 Stipulation of Fact ........ ................... 11-106

30 CFR 1210.155 - What reports must I submit for Federal onshore stripper oil properties?

Code of Federal Regulations, 2014 CFR

2014-07-01

... stripper oil properties? 1210.155 Section 1210.155 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE..., Gas, and Geothermal Resources § 1210.155 What reports must I submit for Federal onshore stripper oil... Management (BLM) under 43 CFR 3103.4-2 must submit Form ONRR-4377, Stripper Royalty Rate Reduction...

30 CFR 1210.155 - What reports must I submit for Federal onshore stripper oil properties?

Code of Federal Regulations, 2012 CFR

2012-07-01

... stripper oil properties? 1210.155 Section 1210.155 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE..., Gas, and Geothermal Resources § 1210.155 What reports must I submit for Federal onshore stripper oil... Management (BLM) under 43 CFR 3103.4-2 must submit Form MMS-4377, Stripper Royalty Rate Reduction...

30 CFR 1210.155 - What reports must I submit for Federal onshore stripper oil properties?

Code of Federal Regulations, 2013 CFR

2013-07-01

... stripper oil properties? 1210.155 Section 1210.155 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE..., Gas, and Geothermal Resources § 1210.155 What reports must I submit for Federal onshore stripper oil... Management (BLM) under 43 CFR 3103.4-2 must submit Form ONRR-4377, Stripper Royalty Rate Reduction...

Metal-ligand synergistic effects in the complex Ni(η(2)-TEMPO)2: synthesis, structures, and reactivity.

PubMed

Isrow, Derek; DeYonker, Nathan J; Koppaka, Anjaneyulu; Pellechia, Perry J; Webster, Charles Edwin; Captain, Burjor

2013-12-16

In the current investigation, reactions of the "bow-tie" Ni(η(2)-TEMPO)2 complex with an assortment of donor ligands have been characterized experimentally and computationally. While the Ni(η(2)-TEMPO)2 complex has trans-disposed TEMPO ligands, proton transfer from the C-H bond of alkyne substrates (phenylacetylene, acetylene, trimethylsilyl acetylene, and 1,4-diethynylbenzene) produce cis-disposed ligands of the form Ni(η(2)-TEMPO)(κ(1)-TEMPOH)(κ(1)-R). In the case of 1,4-diethynylbenzene, a two-stage reaction occurs. The initial product Ni(η(2)-TEMPO)(κ(1)-TEMPOH)[κ(1)-CC(C6H4)CCH] is formed first but can react further with another equivalent of Ni(η(2)-TEMPO)2 to form the bridged complex Ni(η(2)-TEMPO)(κ(1)-TEMPOH)[κ(1)-κ(1)-CC(C6H4)CC]Ni(η(2)-TEMPO)(κ(1)-TEMPOH). The corresponding reaction with acetylene, which could conceivably also yield a bridging complex, does not occur. Via density functional theory (DFT), addition mechanisms are proposed in order to rationalize thermodynamic and kinetic selectivity. Computations have also been used to probe the relative thermodynamic stabilities of the cis and trans addition products and are in accord with experimental results. Based upon the computational results and the geometry of the experimentally observed product, a trans-cis isomerization must occur.

C3 Polymorphism Influences Circulating Levels of C3, ASP and Lipids in Schizophrenic Patients.

PubMed

Nsaiba, Mohamed Jalloul; Lapointe, Marc; Mabrouk, Hajer; Douki, Wahiba; Gaha, Lotfi; Pérusse, Louis; Bouchard, Claude; Jrad, Besma Bel Hadj; Cianflone, Katherine

2015-05-01

Excessive activation of complement is associated with many diseases including schizophrenia. Investigation of C3 polymorphisms, circulating C3, cleavage product ASP/C3adesArg, and lipid metabolism. Cross-sectional analysis. C3 genotyping (CC vs GG for R102L) was performed on 434 Tunisian people consisting of 272 schizophrenic (SZ) patients and 162 control subjects. In a age- and gender-matched subgroups of the three genotypes (131 SZ and 112 NOR), plasma triglycerides, total cholesterol (C), LDL-C, HDL-C, ASP, and complement C3 were measured. C3 gene polymorphism influences BMI and plasma C3, ASP, triglyceride, total cholesterol, LDL-C and HDL-C among SZ patients (p < 0.05-0.0001), with increasing values demonstrated from CC (common form) to CG (heterozygote form) to GG (rare homozygote) forms. Significant correlations between plasma C3 and BMI, triglyceride, HDL-C and ASP (p < 0.05-0.0001) were observed, while ASP correlated with BMI and LDL-C (p = 0.005, p = 0.001, respectively) in SZ patients. Further, proportional conversion of C3 to ASP (%ASP/C3) also increased (p < 0.0001, GG>CG>CC). C3 polymorphisms and plasma C3, ASP and %ASP/C3 correlated with lipid parameters in this SZ population, suggesting that factors predisposing patients to schizophrenia are permissive for complement pathway activation and dyslipidemic influences.

Lennard-Jones fluids in two-dimensional nano-pores. Multi-phase coexistence and fluid structure

NASA Astrophysics Data System (ADS)

Yatsyshin, Petr; Savva, Nikos; Kalliadasis, Serafim

2014-03-01

We present a number of fundamental findings on the wetting behaviour of nano-pores. A popular model for fluid confinement is a one-dimensional (1D) slit pore formed by two parallel planar walls and it exhibits capillary condensation (CC): a first-order phase transition from vapour to capillary-liquid (Kelvin shift). Capping such a pore at one end by a third orthogonal wall forms a prototypical two-dimensional (2D) pore. We show that 2D pores possess a wetting temperature such that below this temperature CC remains of first order, above it becomes a continuous phase transition manifested by a slab of capillary-liquid filling the pore from the capping wall. Continuous CC exhibits hysteresis and can be preceded by a first-order capillary prewetting transition. Additionally, liquid drops can form in the corners of the 2D pore (remnant of 2D wedge prewetting). The three fluid phases, vapour, capillary-liquid slab and corner drops, can coexist at the pore triple point. Our model is based on the statistical mechanics of fluids in the density functional formulation. The fluid-fluid and fluid-substrate interactions are dispersive. We analyze in detail the microscopic fluid structure, isotherms and full phase diagrams. Our findings also suggest novel ways to control wetting of nano-pores. We are grateful to the European Research Council via Advanced Grant No. 247031 for support.

Near-infrared and ultraviolet induced isomerization of crotonic acid in N{sub 2} and Xe cryomatrices: First observation of two high-energy trans C–O conformers and mechanistic insights

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuş, Nihal; Department of Physics, Anadolu University, 26470 Eskişehir; Fausto, Rui, E-mail: rfausto@ci.uc.pt

2014-12-21

E-crotonic acid was isolated in cryogenic solid N{sub 2} and xenon matrices, and subjected to Laser ultraviolet (UV) and near-infrared (NIR) irradiations. In the deposited matrices, the two low-energy cis C–O E-cc and E-ct conformers, which are the only forms significantly populated in the gas phase, were observed. UV irradiation (λ= 250 nm) of the compound in N{sub 2} matrix allows for experimental detection, not just of the two low-energy cis C–O isomers of Z-crotonic acid previously observed in the experiments carried out in argon matrix [Z-cc and Z-ct; R. Fausto, A. Kulbida, and O. Schrems, J. Chem. Soc., Faradaymore » Trans. 91, 3755–3770 (1995)] but also of the never observed before high-energy forms of both E- and Z-crotonic acids bearing the carboxylic acid group in the trans arrangement (E-tc and Z-tc conformers). In turn, NIR irradiation experiments in the N{sub 2} matrix allow to produce the high-energy E-tc trans C–O conformer in a selective way, from the initially deposited E-cc form. The vibrational signatures of all the 6 rotameric structures of the crotonic acids experimentally observed, including those of the new trans C–O forms, were determined and the individual spectra fully assigned, also with support of theoretically obtained data. On the other hand, as found before for the compound isolated in argon matrix, the experiments performed in xenon matrix failed to experimental detection of the trans C–O forms. This demonstrates that in noble gas matrices these forms are not stable long enough to allow for their observation by steady state spectroscopy techniques. In these matrices, the trans C–O forms convert spontaneously into their cis C–O counterparts, by tunnelling. Some mechanistic details of the studied processes were extracted and discussed.« less

Mobius Molecules

ERIC Educational Resources Information Center

Eckert, J. M.

1973-01-01

Discusses formation of chemical molecules via Mobius strip intermediates, and concludes that many special physics-chemical properties of the fully closed circular form (1) of polyoma DNA are explainable by this topological feature. (CC)

Cartograms Facilitate Communication of Climate Change Risks and Responsibilities

NASA Astrophysics Data System (ADS)

Döll, Petra

2017-12-01

Communication of climate change (CC) risks is challenging, in particular if global-scale spatially resolved quantitative information is to be conveyed. Typically, visualization of CC risks, which arise from the combination of hazard, exposure and vulnerability, is confined to showing only the hazards in the form of global thematic maps. This paper explores the potential of contiguous value-by-area cartograms, that is, distorted density-equalizing maps, for improving communication of CC risks and the countries' differentiated responsibilities for CC. Two global-scale cartogram sets visualize, as an example, groundwater-related CC risks in 0.5° grid cells, another one the correlation of (cumulative) fossil-fuel carbon dioxide emissions with the countries' population and gross domestic product. Viewers of the latter set visually recognize the lack of global equity and that the countries' wealth has been built on harmful emissions. I recommend that CC risks are communicated by bivariate gridded cartograms showing the hazard in color and population, or a combination of population and a vulnerability indicator, by distortion of grid cells. Gridded cartograms are also appropriate for visualizing the availability of natural resources to humans. For communicating complex information, sets of cartograms should be carefully designed instead of presenting single cartograms. Inclusion of a conventionally distorted map enhances the viewers' capability to take up the information represented by distortion. Empirical studies about the capability of global cartograms to convey complex information and to trigger moral emotions should be conducted, with a special focus on risk communication.

Gordonia humi sp. nov., isolated from soil.

PubMed

Kämpfer, P; Young, Chiu-Chung; Chu, Jiunn-Nan; Frischmann, A; Busse, H-J; Arun, A B; Shen, Fo-Ting; Rekha, P D

2011-01-01

A Gram-stain-positive, non-endospore-forming actinobacterium (CC-12301(T)) was isolated from soil attached to a spawn used in the laboratory to grow the edible mushroom Agaricus brasiliensis. Based on 16S rRNA gene sequence similarities, strain CC-12301(T) was shown to belong to the genus Gordonia and was most closely related to the type strains of Gordonia hydrophobica (97.6 % similarity), Gordonia terrae (97.5 %), Gordonia amarae (97.5 %) and Gordonia malaquae (97.4 %). The quinone system was determined to consist predominantly of menaquinone MK-9(H(2)), minor amounts of MK-8(H(2)) and MK-7(H(2)). The polar lipid profile consisted of the major compounds diphosphatidylglycerol and phosphatidylethanolamine, moderate amounts of two phosphatidylinositol mannosides and phosphatidylinositol and minor amounts of phosphatidylglycerol, three unidentified glycolipids, two phosphoglycolipids and a phospholipid. Mycolic acids were present. These chemotaxonomic traits and the major fatty acids, which were C(16 : 1) cis9, C(16 : 0), C(18 : 1) and tuberculostearic acid (10-methyl C(18 : 0)), supported the affiliation of strain CC-12301(T) to the genus Gordonia. The results of physiological and biochemical tests allowed clear phenotypic differentiation of strain CC-12301(T) from the most closely related Gordonia species. Strain CC-12301(T) therefore represents a novel species, for which the name Gordonia humi sp. nov. is proposed, with the type strain CC-12301(T) (=DSM 45298(T) =CCM 7727(T)).

Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway

PubMed Central

Weeden, Clare E.; Chen, Yunshun; Ma, Stephen B.; Hu, Yifang; Ramm, Georg; Sutherland, Kate D.; Smyth, Gordon K.

2017-01-01

Lung squamous cell carcinoma (SqCC), the second most common subtype of lung cancer, is strongly associated with tobacco smoking and exhibits genomic instability. The cellular origins and molecular processes that contribute to SqCC formation are largely unexplored. Here we show that human basal stem cells (BSCs) isolated from heavy smokers proliferate extensively, whereas their alveolar progenitor cell counterparts have limited colony-forming capacity. We demonstrate that this difference arises in part because of the ability of BSCs to repair their DNA more efficiently than alveolar cells following ionizing radiation or chemical-induced DNA damage. Analysis of mice harbouring a mutation in the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a key enzyme in DNA damage repair by nonhomologous end joining (NHEJ), indicated that BSCs preferentially repair their DNA by this error-prone process. Interestingly, polyploidy, a phenomenon associated with genetically unstable cells, was only observed in the human BSC subset. Expression signature analysis indicated that BSCs are the likely cells of origin of human SqCC and that high levels of NHEJ genes in SqCC are correlated with increasing genomic instability. Hence, our results favour a model in which heavy smoking promotes proliferation of BSCs, and their predilection for error-prone NHEJ could lead to the high mutagenic burden that culminates in SqCC. Targeting DNA repair processes may therefore have a role in the prevention and therapy of SqCC. PMID:28125611

[The risk of neoplastic processes transformation in cervix uteri].

PubMed

Kiseleva, V I; Krikunova, L I; Mkrtchian, L S; Liubina, L V; Beziaeva, G P; Panarina, L V; Zamuliaeva, I A

2014-01-01

There was performed a comparative analysis of quantitative load and physical status of human papillomavirus (HPV) type 16 in groups of patients with cervical intraepithelial neoplasia (CIN)--25 people and cervical cancer (CC)--85 people. According to the analysis there were selected criteria appropriate to a combination of adverse factors that characterized HPV- infection and at the same time estimated both quantitative load and physical status of the virus: high viral load (> 6,5 lg copies of HPV DNA per 100000 cells) in episomal form or low load (< 6,5 lg copies of HPV DNA per 100000 cells) in integrated form of the virus. According to calculations a relative chance of appearing of CC in CIN patients with unfavorable combination of factors was 7,5 times higher than in other patients.

NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function.

PubMed

Sharma, Alok K; Birrane, Gabriel; Anklin, Clemens; Rigby, Alan C; Alper, Seth L

2017-04-28

Nitrovasodilators relax vascular smooth-muscle cells in part by modulating the interaction of the C-terminal coiled-coil domain (CC) and/or the leucine zipper (LZ) domain of the myosin light-chain phosphatase component, myosin-binding subunit (MBS), with the N-terminal LZ domain of protein kinase G (PKG)-Iα. Despite the importance of vasodilation in cardiovascular homeostasis and therapy, our structural understanding of the MBS CC interaction with LZ PKG-1α has remained limited. Here, we report the 3D NMR solution structure of homodimeric CC MBS in which amino acids 932-967 form a coiled-coil of two monomeric α-helices in parallel orientation. We found that the structure is stabilized by non-covalent interactions, with dominant contributions from hydrophobic residues at a and d heptad positions. Using NMR chemical-shift perturbation (CSP) analysis, we identified a subset of hydrophobic and charged residues of CC MBS (localized within and adjacent to the C-terminal region) contributing to the dimer-dimer interaction interface between homodimeric CC MBS and homodimeric LZ PKG-Iα. 15 N backbone relaxation NMR revealed the dynamic features of the CC MBS interface residues identified by NMR CSP. Paramagnetic relaxation enhancement- and CSP-NMR-guided HADDOCK modeling of the dimer-dimer interface of the heterotetrameric complex exhibits the involvement of non-covalent intermolecular interactions that are localized within and adjacent to the C-terminal regions of each homodimer. These results deepen our understanding of the binding restraints of this CC MBS·LZ PKG-Iα low-affinity heterotetrameric complex and allow reevaluation of the role(s) of myosin light-chain phosphatase partner polypeptides in regulation of vascular smooth-muscle cell contractility. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice.

PubMed

Zhang, Jing; Malo, Danielle; Mott, Richard; Panthier, Jean-Jacques; Montagutelli, Xavier; Jaubert, Jean

2018-04-27

Salmonella is a Gram-negative bacterium causing a wide range of clinical syndromes ranging from typhoid fever to diarrheic disease. Non-typhoidal Salmonella (NTS) serovars infect humans and animals, causing important health burden in the world. Susceptibility to salmonellosis varies between individuals under the control of host genes, as demonstrated by the identification of over 20 genetic loci in various mouse crosses. We have investigated the host response to S. Typhimurium infection in 35 Collaborative Cross (CC) strains, a genetic population which involves wild-derived strains that had not been previously assessed. One hundred and forty-eight mice from 35 CC strains were challenged intravenously with 1000 colony-forming units (CFUs) of S. Typhimurium. Bacterial load was measured in spleen and liver at day 4 post-infection. CC strains differed significantly (P < 0.0001) in spleen and liver bacterial loads, while sex and age had no effect. Two significant quantitative trait loci (QTLs) on chromosomes 8 and 10 and one suggestive QTL on chromosome 1 were found for spleen bacterial load, while two suggestive QTLs on chromosomes 6 and 17 were found for liver bacterial load. These QTLs are caused by distinct allelic patterns, principally involving alleles originating from the wild-derived founders. Using sequence variations between the eight CC founder strains combined with database mining for expression in target organs and known immune phenotypes, we were able to refine the QTLs intervals and establish a list of the most promising candidate genes. Furthermore, we identified one strain, CC042/GeniUnc (CC042), as highly susceptible to S. Typhimurium infection. By exploring a broader genetic variation, the Collaborative Cross population has revealed novel loci of resistance to Salmonella Typhimurium. It also led to the identification of CC042 as an extremely susceptible strain.

Method of low pressure and/or evaporative drying of aerogel

DOEpatents

Mayer, S.T.; Kaschmitter, J.L.; Pekala, R.W.

1995-05-30

A process is described whereby Resorcinol/Formaldehyde (RF) aerogel having a density of about 0.4--1.2 g/cc can be manufactured using a simple air drying procedure. This process is inherently simpler, quicker, and less expensive than the more conventional supercritical or subcritical CO{sub 2} extraction procedures. RF aerogels can be used as produced, such as in insulation applications, or pyrolyzed to form carbon aerogels with a density of about 0.9 g/cc for use in applications such as batteries, supercapacitors, etc.

15 CFR 715.4 - Deadlines for submitting UDOC declarations, No Changes Authorization Forms, Change in Inspection...

Code of Federal Regulations, 2013 CFR

2013-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING UNSCHEDULED DISCRETE ORGANIC CHEMICALS (UDOCs) § 715.4 Deadlines for submitting UDOC declarations...

15 CFR 715.4 - Deadlines for submitting UDOC declarations, No Changes Authorization Forms, Change in Inspection...

Code of Federal Regulations, 2012 CFR

2012-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING UNSCHEDULED DISCRETE ORGANIC CHEMICALS (UDOCs) § 715.4 Deadlines for submitting UDOC declarations...

15 CFR 715.4 - Deadlines for submitting UDOC declarations, No Changes Authorization Forms, Change in Inspection...

Code of Federal Regulations, 2010 CFR

2010-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING UNSCHEDULED DISCRETE ORGANIC CHEMICALS (UDOCs) § 715.4 Deadlines for submitting UDOC declarations...

15 CFR 715.4 - Deadlines for submitting UDOC declarations, No Changes Authorization Forms, Change in Inspection...

Code of Federal Regulations, 2011 CFR

2011-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING UNSCHEDULED DISCRETE ORGANIC CHEMICALS (UDOCs) § 715.4 Deadlines for submitting UDOC declarations...

76 FR 10429 - Petition for Exemption; Summary of Petition Received

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... information was submitted via phone conversation and in letter form. The petitioner had a conversation with.... Both the Record of Conversation from the phone call and the information submitted by letter are...

2 CFR 200.507 - Program-specific audits.

Code of Federal Regulations, 2014 CFR

2014-01-01

... auditee must electronically submit to the FAC the data collection form prepared in accordance with § 200... submitted to the FAC. (d) Other sections of this part may apply. Program-specific audits are subject to: (1...

42 CFR 455.434 - Criminal background checks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... that each such provider or person submit fingerprints. (2) The State Medicaid agency must require a... submit a set of fingerprints, in a form and manner to be determined by the State Medicaid agency, within...

42 CFR 455.434 - Criminal background checks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... that each such provider or person submit fingerprints. (2) The State Medicaid agency must require a... submit a set of fingerprints, in a form and manner to be determined by the State Medicaid agency, within...

42 CFR 455.434 - Criminal background checks.

Code of Federal Regulations, 2014 CFR

2014-10-01

... that each such provider or person submit fingerprints. (2) The State Medicaid agency must require a... submit a set of fingerprints, in a form and manner to be determined by the State Medicaid agency, within...

42 CFR 455.434 - Criminal background checks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... that each such provider or person submit fingerprints. (2) The State Medicaid agency must require a... submit a set of fingerprints, in a form and manner to be determined by the State Medicaid agency, within...

An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma

PubMed Central

Gossage, Lucy; Pires, Douglas E. V.; Olivera-Nappa, Álvaro; Asenjo, Juan; Bycroft, Mark; Blundell, Tom L.; Eisen, Tim

2014-01-01

Mutations in the von Hippel–Lindau (VHL) gene are pathogenic in VHL disease, congenital polycythaemia and clear cell renal carcinoma (ccRCC). pVHL forms a ternary complex with elongin C and elongin B, critical for pVHL stability and function, which interacts with Cullin-2 and RING-box protein 1 to target hypoxia-inducible factor for polyubiquitination and proteasomal degradation. We describe a comprehensive database of missense VHL mutations linked to experimental and clinical data. We use predictions from in silico tools to link the functional effects of missense VHL mutations to phenotype. The risk of ccRCC in VHL disease is linked to the degree of destabilization resulting from missense mutations. An optimized binary classification system (symphony), which integrates predictions from five in silico methods, can predict the risk of ccRCC associated with VHL missense mutations with high sensitivity and specificity. We use symphony to generate predictions for risk of ccRCC for all possible VHL missense mutations and present these predictions, in association with clinical and experimental data, in a publically available, searchable web server. PMID:24969085

Label-noise resistant logistic regression for functional data classification with an application to Alzheimer's disease study.

PubMed

Lee, Seokho; Shin, Hyejin; Lee, Sang Han

2016-12-01

Alzheimer's disease (AD) is usually diagnosed by clinicians through cognitive and functional performance test with a potential risk of misdiagnosis. Since the progression of AD is known to cause structural changes in the corpus callosum (CC), the CC thickness can be used as a functional covariate in AD classification problem for a diagnosis. However, misclassified class labels negatively impact the classification performance. Motivated by AD-CC association studies, we propose a logistic regression for functional data classification that is robust to misdiagnosis or label noise. Specifically, our logistic regression model is constructed by adopting individual intercepts to functional logistic regression model. This approach enables to indicate which observations are possibly mislabeled and also lead to a robust and efficient classifier. An effective algorithm using MM algorithm provides simple closed-form update formulas. We test our method using synthetic datasets to demonstrate its superiority over an existing method, and apply it to differentiating patients with AD from healthy normals based on CC from MRI. © 2016, The International Biometric Society.

Influence of micro-oxidation on joints of C/C composites and GH3044 for large-size aerospace parts

NASA Astrophysics Data System (ADS)

Shi, Xiaohong; Jin, Xiuxiu; Yan, Ningning; Yang, Li

2017-11-01

To improve the bonding strength of carbon/carbon (C/C) composites and GH3044 nickel-based superalloy, the bonding interlayer with Ti/Ni/Cu/Ni multiple foils were prepared by a two-step technique involving micro-oxidation and partial transient liquid phase (PTLP) process. Interface characteristics and mechanical behavior of joints were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), laser scanning confocal microscope (LSCM) and energy X-ray dispersive spectrometer (EDS). Results show that a porous layer on C/C composites is formed by micro-oxidation for more than 2 min at 1073 K in air, which provides a diffusion path for liquid phase to infiltrate into C/C substrate and generate a wedge interlocking interface. After micro-oxidation for 4 min, the shear strength of joints reaches 32.09 ± 1.98 MPa what is 36.73% higher than that of joints without micro-oxidation (23.47 ± 1.15 MPa). The increase of shear strength remarkably depends on physical interlocking and chemical bonding at porous interface.

Is It Possible Using Handgrip Strength Instead of Body Mass Index in MNA-SF Test to Assess the Nutritional Status of Geriatric Patients?

PubMed

Kizilarslanoglu, M C; Kilic, M K; Gokce, D; Sakalar, T; Ulger, Z

2017-01-01

In Mini-Nutritional Assessment-Short Form (MNA-SF) test, a practical and reliable alternative parameter is still necessary for patients with difficult body mass index evaluation. We aimed to show whether or not handgrip strength may be used instead of body mass index (BMI) in MNA-SF test. MNA-SF test scores, calf circumferences (CC), handgrip strength (HGS), and BMI of 191 patients were evaluated. The first one of calculated MNA-SF tests was with BMI, the second one with CC, and the last one with HGS. Zero point was given if CC was <31 cm and 3 points were given if CC was ≥31 cm. Zero, 1, 2, and 3 points were given if the loss of HGS when compared to expected HGS were ≥%60, from ≥%30 to <%60, from ≥%10 to <%30, and <%10 or greater than expected HGS, respectively. MNA-SF scores and nutritional status according to these three measures were compared. Mean age and median MNA-SF scores of the patients were 75±7.6 years and 12 points (min-max: 0-14) respectively. There were strongly positive correlations between MNA-SF scores with BMI and CC, with BMI and HGS, and with CC and HGS (r=0.938 p<0.001, r=0.938 p<0.001, r=0.914 p<0.001, respectively). Substantial agreement in nutritional status of the patients were seen between MNA-SF groups with BMI and CC, with CC and HGS, and with BMI and HGS (kappa: 0.795 p<0.001, kappa: 0.709 p<0.001, and kappa: 0.760 p<0.001, respectively). HGS might be considered instead of BMI in MNA-SF test to assess nutritional status of geriatric patients.

Hawking temperature of constant curvature black holes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cai Ronggen; Myung, Yun Soo; Institute of Basic Science and School of Computer Aided Science, Inje University, Gimhae 621-749

2011-05-15

The constant curvature (CC) black holes are higher dimensional generalizations of Banados-Teitelboim-Zanelli black holes. It is known that these black holes have the unusual topology of M{sub D-1}xS{sup 1}, where D is the spacetime dimension and M{sub D-1} stands for a conformal Minkowski spacetime in D-1 dimensions. The unusual topology and time-dependence for the exterior of these black holes cause some difficulties to derive their thermodynamic quantities. In this work, by using a globally embedding approach, we obtain the Hawking temperature of the CC black holes. We find that the Hawking temperature takes the same form when using both themore » static and global coordinates. Also, it is identical to the Gibbons-Hawking temperature of the boundary de Sitter spaces of these CC black holes.« less

Efficacy of budesonide in collagenous colitis Evaluation of: Miehlke S, Madisch A, Kupcinskas L, et al. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. Gastroenterology 2014;146(5):1222-1230 e1222.

PubMed

Drug, Vasile L; Antoniu, Sabina A

2014-10-01

Collagenous colitis (CC) is a less common colonic disease with variable prevalence and undulating course. Among the available therapies, budesonide was demonstrated to induce a rapid and sustained remission in many cases, but little is known about the comparative efficacy of other treatments, such as mesalamine. Evaluation of a randomized study assessing the efficacy and safety of budesonide over mesalamine in patients with CC. Data from the study showed that budesonide was significantly superior to placebo and to mesalamine and further supports the recommendation of the current guidelines on the use of budesonide in CC. However, other forms of mesalamine may further be evaluated for this disease.

Detection of Low-volume Blood Loss: Compensatory Reserve Versus Traditional Vital Signs

DTIC Science & Technology

2014-01-01

studies have demonstrated that photoplethysmogram (PPG) wave forms obtained with a pulse oximeter sensor significantly change with volume loss.5 With this...donation, including PPG wave forms (OEM III pulse oximeter , Nonin, Minneapolis, MN), and a noninvasive BPwave form (ccNexfin, Edwards Lifesciences, Irvine...a PPG wave form obtained with a pulse oximeter sensor. CRI is calculated after 30 heart beats and is recalculated beat-to-beat in a continuous

Form and Function in Early Clause-Combining

ERIC Educational Resources Information Center

Lustigman, Lyle; Berman, Ruth A.

2016-01-01

The study characterizes developmental trends in early Hebrew clause-combining (CC) by analyzing the interplay between linguistic form and communicative function in different interactional settings. Analysis applied to all utterances produced by three children aged 2;0-3;0 who combined two or more clauses, either self-initiated or on the basis of…

78 FR 28594 - Information Collection Being Reviewed by the Federal Communications Commission

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-15

... information on the respondents, including the use of automated collection techniques or other forms of..., 47 CFR Part 52, Subpart (C) and CC Docket No. 95-116. Form Number: N/A. Type of Review: Extension of... suits their needs and enhancing competition. In the Porting Interval Order and Further Notice, the...

Second Line of Defense: Electronic Maintenance Reports, Local Maintenance Provider User Guide, Rev. 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leigh, Richard J.

2012-09-01

The Electronic Maintenance Report forms allow Local Maintenance Providers (LMP) and other program staff to enter maintenance information into a simple and secure system. This document describes the features and information required to complete the Maintenance Report forms. It is expected that all Corrective Maintenance Reports from LMPs will be submitted electronically into the SLD Portal. As an exception (e.g., when access to the SLD Portal is unavailable), Maintenance Reports can be submitted via a secure Adobe PDF form available through the Sustainability Manager assigned to each country.

Traffic crash statistics report, 2009

DOT National Transportation Integrated Search

2010-06-23

This report is compiled from long form traffic crash reports submitted by state and local law enforcement agencies. The Department summarizes all the submitted information for this report. in general, the 2009 crash statistics show a positive trend i...

78 FR 24152 - Softwood Lumber Research, Promotion, Consumer Education and Industry Information Order; Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

...: Interested persons are invited to submit comments concerning this notice. Comments should be submitted online... requirements for individuals filling out reports and remitting assessments to the Board. The forms are simple...

13 CFR 115.70 - Claims for reimbursement of Losses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... are submitted. A PSB Surety must submit claims for reimbursement on a form approved by SBA no later... of all claims or suits arising from a defaulted bond, and compromise, settle or defend the suits. The...

42 CFR 124.605 - Reporting and record maintenance requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Content of report. The report must be submitted on a form prescribed by the Secretary and must include... when submitting it to the Secretary. (4) Institution of suit. Not later than 10 days after being served...

42 CFR 124.605 - Reporting and record maintenance requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Content of report. The report must be submitted on a form prescribed by the Secretary and must include... when submitting it to the Secretary. (4) Institution of suit. Not later than 10 days after being served...

42 CFR 124.605 - Reporting and record maintenance requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Content of report. The report must be submitted on a form prescribed by the Secretary and must include... when submitting it to the Secretary. (4) Institution of suit. Not later than 10 days after being served...

13 CFR 115.70 - Claims for reimbursement of Losses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... are submitted. A PSB Surety must submit claims for reimbursement on a form approved by SBA no later... of all claims or suits arising from a defaulted bond, and compromise, settle or defend the suits. The...

13 CFR 115.70 - Claims for reimbursement of Losses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... are submitted. A PSB Surety must submit claims for reimbursement on a form approved by SBA no later... of all claims or suits arising from a defaulted bond, and compromise, settle or defend the suits. The...

13 CFR 115.70 - Claims for reimbursement of Losses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... are submitted. A PSB Surety must submit claims for reimbursement on a form approved by SBA no later... of all claims or suits arising from a defaulted bond, and compromise, settle or defend the suits. The...

42 CFR 124.605 - Reporting and record maintenance requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Content of report. The report must be submitted on a form prescribed by the Secretary and must include... when submitting it to the Secretary. (4) Institution of suit. Not later than 10 days after being served...

42 CFR 124.605 - Reporting and record maintenance requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Content of report. The report must be submitted on a form prescribed by the Secretary and must include... when submitting it to the Secretary. (4) Institution of suit. Not later than 10 days after being served...

13 CFR 115.70 - Claims for reimbursement of Losses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... are submitted. A PSB Surety must submit claims for reimbursement on a form approved by SBA no later... of all claims or suits arising from a defaulted bond, and compromise, settle or defend the suits. The...

Community-Based Psychosocial Treatment Has an Impact on Social Processing and Functional Outcome in Schizophrenia.

PubMed

Varga, Eszter; Endre, Szilvia; Bugya, Titusz; Tényi, Tamás; Herold, Róbert

2018-01-01

Schizophrenic patients have serious impairments in social cognition, which often persists after significant reduction in clinical symptoms. Community-based psychosocial treatments aim to recover social functioning for mentally ill individuals. Our aim was to examine prospective changes in social cognition and functional outcomes in two groups of schizophrenic patients involved in two forms of community-based psychosocial treatments namely case management (CM) and community-based club (CC) compared to a matched, treatment as usual (TAU) group of patients. We hypothesized that CC and CM groups would exhibit better functional and social cognitive outcomes after a 6-month long psychosocial treatment period. Seventy-five patients participated either in CC, CM or TAU. Both CC and CM took part in community-based psychosocial treatment programs including trainings, such as communication and assertiveness trainings. In addition, CC provided group therapeutic treatments and a continuously available day care where patients had the possibility to participate in various social interactions. All participants were in remission, and on maintenance antipsychotic treatment. Participants were assessed on all study variables at two time points: baseline and after 6 months with a battery of questionnaires that examined affective face perception, affective prosody perception, pragmatic language comprehension and ToM. Our results showed that functional outcomes improved significantly in the CC as well as in the CM groups, in contrast to the TAU group. While analyzing summary scores of social cognition, it was found that only the CC group increased its performance in social cognition. In addition, a significant between-group difference in social cognitive function was found after 6 months between the three groups, with the CC group performing best. When investigating associations between changes in social cognition and changes in functional outcomes during a 6-month long treatment period, we found significant correlations between the two variables both in the CC and in the CM groups. Based on our results, we suggest that a rich interpersonal network and social support have highly beneficial effects on social cognition and we would like to emphasize the necessity of offering community-based psychosocial treatments beside antipsychotic medications as early as possible as a crucial part of the complex therapy of schizophrenia.

21 CFR 1271.22 - How and where do I register and submit an HCT/P list?

Code of Federal Regulations, 2011 CFR

2011-04-01

... may submit Form FDA 3356 to the Center for Biologics Evaluation and Research (HFM-775), Food and Drug... 21 Food and Drugs 8 2011-04-01 2011-04-01 false How and where do I register and submit an HCT/P list? 1271.22 Section 1271.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND...

21 CFR 1271.22 - How and where do I register and submit an HCT/P list?

Code of Federal Regulations, 2010 CFR

2010-04-01

... may submit Form FDA 3356 to the Center for Biologics Evaluation and Research (HFM-775), Food and Drug... 21 Food and Drugs 8 2010-04-01 2010-04-01 false How and where do I register and submit an HCT/P list? 1271.22 Section 1271.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND...

Alternative oxidase (AOX) constitutes a small family of proteins in Citrus clementina and Citrus sinensis L. Osb.

PubMed

Araújo Castro, Jacqueline; Gomes Ferreira, Monique Drielle; Santana Silva, Raner José; Andrade, Bruno Silva; Micheli, Fabienne

2017-01-01

The alternative oxidase (AOX) protein is present in plants, fungi, protozoa and some invertebrates. It is involved in the mitochondrial respiratory chain, providing an alternative route for the transport of electrons, leading to the reduction of oxygen to form water. The present study aimed to characterize the family of AOX genes in mandarin (Citrus clementina) and sweet orange (Citrus sinensis) at nucleotide and protein levels, including promoter analysis, phylogenetic analysis and C. sinensis gene expression. This study also aimed to do the homology modeling of one AOX isoform (CcAOXd). Moreover, the molecular docking of the CcAOXd protein with the ubiquinone (UQ) was performed. Four AOX genes were identified in each citrus species. These genes have an open reading frame (ORF) ranging from 852 bp to 1150 bp and a number of exons ranging from 4 to 9. The 1500 bp-upstream region of each AOX gene contained regulatory cis-elements related to internal and external response factors. CsAOX genes showed a differential expression in citrus tissues. All AOX proteins were predicted to be located in mitochondria. They contained the conserved motifs LET, NERMHL, LEEEA and RADE-H as well as several putative post-translational modification sites. The CcAOXd protein was modeled by homology to the AOX of Trypanosona brucei (45% of identity). The 3-D structure of CcAOXd showed the presence of two hydrophobic helices that could be involved in the anchoring of the protein in the inner mitochondrial membrane. The active site of the protein is located in a hydrophobic environment deep inside the AOX structure and contains a diiron center. The molecular docking of CcAOXd with UQ showed that the binding site is a recessed pocket formed by the helices and submerged in the membrane. These data are important for future functional studies of citrus AOX genes and/or proteins, as well as for biotechnological approaches leading to AOX inhibition using UQ homologs.

Alternative oxidase (AOX) constitutes a small family of proteins in Citrus clementina and Citrus sinensis L. Osb

PubMed Central

Araújo Castro, Jacqueline; Gomes Ferreira, Monique Drielle; Santana Silva, Raner José; Andrade, Bruno Silva

2017-01-01

The alternative oxidase (AOX) protein is present in plants, fungi, protozoa and some invertebrates. It is involved in the mitochondrial respiratory chain, providing an alternative route for the transport of electrons, leading to the reduction of oxygen to form water. The present study aimed to characterize the family of AOX genes in mandarin (Citrus clementina) and sweet orange (Citrus sinensis) at nucleotide and protein levels, including promoter analysis, phylogenetic analysis and C. sinensis gene expression. This study also aimed to do the homology modeling of one AOX isoform (CcAOXd). Moreover, the molecular docking of the CcAOXd protein with the ubiquinone (UQ) was performed. Four AOX genes were identified in each citrus species. These genes have an open reading frame (ORF) ranging from 852 bp to 1150 bp and a number of exons ranging from 4 to 9. The 1500 bp-upstream region of each AOX gene contained regulatory cis-elements related to internal and external response factors. CsAOX genes showed a differential expression in citrus tissues. All AOX proteins were predicted to be located in mitochondria. They contained the conserved motifs LET, NERMHL, LEEEA and RADE-H as well as several putative post-translational modification sites. The CcAOXd protein was modeled by homology to the AOX of Trypanosona brucei (45% of identity). The 3-D structure of CcAOXd showed the presence of two hydrophobic helices that could be involved in the anchoring of the protein in the inner mitochondrial membrane. The active site of the protein is located in a hydrophobic environment deep inside the AOX structure and contains a diiron center. The molecular docking of CcAOXd with UQ showed that the binding site is a recessed pocket formed by the helices and submerged in the membrane. These data are important for future functional studies of citrus AOX genes and/or proteins, as well as for biotechnological approaches leading to AOX inhibition using UQ homologs. PMID:28459876

Structures and electron affinity of XO30,-, XOF40,- and XO2F20,- (X = P, As, Sb, Bi): a theoretical study of novel superhalogen formulae and exceptions of superhalogen formulae

NASA Astrophysics Data System (ADS)

Yang, Yi-Fan; Cui, Zhong-Hua; Ding, Yi-Hong

2015-03-01

Most superhalogen species are in the form of oxides or halides. To enrich the family of superhalogen species, herein, we investigated the structures and electron affinity (EA) values of higher group 15 elements (X = P, As, Sb, Bi) oxyfluoride species XO30,-, XOF40,- and XO2F20,-, at the CCSD(T)/aug-cc-pVTZ-pp & aug-cc-pVTZ //B3LYP/aug-cc-pVTZ-pp & aug-cc-pVTZ levels (aug-cc-pVTZ-pp for X = Sb and Bi). Some oxyfluoride species, i.e., PO2F20,-, AsO2F20,-, SbO2F20,-, POF40,-, AsOF40,-, SbOF40,- and BiOF40,-, were found to possess higher EA (VDE: 5.0-6.2 eV; ADE: 4.5-5.5 eV) than halogens (F: 3.4 eV; Cl: 3.6 eV). Thus, we recommended that the oxyfluorides in the form of XO2F20,- and XOF40,- should be considered as potential superhalogens, which have not been considered previously. Surprisingly, we showed that BiO3 and BiO2F2, in superhalogen formulae, possess a high vertical detachment energy (VDE) yet a low adiabatic detachment energy (ADE). This is in marked contrast to the previously reported superhalogens, which generally contain both the high VDE and high ADE values. It is the first report about exceptions of superhalogen formulae. These findings revealed that for the analogous main-group compounds with the same structural formula, the difference in the metallic property of the core element could lead to the significant difference in the ground structures of either the anionic or neutral structures, which would result in the much differed superhalogen features.

Molecular Diagnosis for Nodal Metastasis in Endoscopically Managed Cervical Cancer: The Accuracy of the APTIMA Test to Detect High-risk Human Papillomavirus Messenger RNA in Sentinel Lymph Nodes.

PubMed

Köhler, Christhardt; Le, Xin; Dogan, Nasuh Utku; Pfiffer, Tatiana; Schneider, Achim; Marnitz, Simone; Bertolini, Julia; Favero, Giovanni

2016-01-01

To evaluate the feasibility and accuracy of a commercially available test to detect E6/E7 mRNA of 14 subtypes of high-risk HPVs (APTIMA; Hologic, Bedford, MA) in the sentinel lymph nodes of CC patients laparoscopically operated. Prospective pilot study. The study was conducted in the Department of Advanced Operative and Oncologic Gynecology, Asklepios Hospital, Hamburg, Germany. 54 women with HPV-positive CC submitted to laparoscopic sentinel node biopsy alone or sentinel node biopsy followed by systematic pelvic and/or para-aortic endoscopic lymphadenectomy. All removed sentinel lymph nodes (SLNs) underwent sample collection by cytobrush for the APTIMA assay before frozen section. Results obtained with the HPV mRNA test were compared with the definitive histopathological analysis of the SLNs and additional lymph nodes removed. A total of 125 SLNs (119 pelvic and 6 paraaortic) were excised with a mean number of 2.3 SLNs per patient. Final histopathologic analysis confirmed nodal metastases in 10 SLNs from 10 different patients (18%). All the histologically confirmed metastatic lymph nodes were also HPV E6/E7 mRNA positive, resulting in a sensitivity of 100%. Four histologically free sentinel nodes were positive for HPV E6/E7 mRNA, resulting in a specificity of 96.4%. The HPV E6/E7 mRNA assay in the SLNs of patients with CC is feasible and highly accurate. The detection of HPV mRNA in 4 women with negative SLNs might denote a shift from microscopic identification of metastasis to the molecular level. The prognostic value of this findings awaits further verification. Copyright © 2016. Published by Elsevier Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiao, Hai; Cheng, Tao; Goddard, William A.

Energy and environmental concerns demand development of more efficient and selective electrodes for electrochemical reduction of CO 2 to form fuels and chemicals. Since Cu is the only pure metal exhibiting reduction to form hydrocarbon chemicals, we focus here on the Cu (111) electrode. We present a methodology for density functional theory calculations to obtain accurate onset electrochemical potentials with explicit constant electrochemical potential and pH effects using implicit solvation. We predict the atomistic mechanisms underlying electrochemical reduction of CO, finding that (1) at acidic pH, the C 1 pathway proceeds through COH to CHOH to form CH 4 whilemore » C 2 (C 3) pathways are kinetically blocked; (2) at neutral pH, the C 1 and C 2 (C 3) pathways share the COH common intermediate, where the branch to C-C coupling is realized by a novel CO-COH pathway; and (3) at high pH, early C-C coupling through adsorbed CO dimerization dominates, suppressing the C 1 pathways by kinetics, thereby boosting selectivity for multi-carbon products.« less

pH-Dependent Solution Structure and Activity of a Reduced Form of the Host-Defense Peptide Myticin C (Myt C) from the Mussel Mytilus galloprovincialis

PubMed Central

Martinez-Lopez, Alicia; Encinar, Jose Antonio; Medina-Gali, Regla Maria; Balseiro, Pablo; Garcia-Valtanen, Pablo; Figueras, Antonio; Novoa, Beatriz; Estepa, Amparo

2013-01-01

Myticin C (Myt C) is a highly variable host-defense peptide (HDP) associated to the immune response in the mediterranean mussel (Mytilus galloprovincialis), which has shown to be active across species due to its strong antiviral activity against a fish rhabdovirus found in fish cells overexpressing this HDP. However, the potential antimicrobial properties of any synthetic analogue of Myt C has not yet been analysed. Thus, in this work we have synthesised the sequence of the mature peptide of Myt C variant c and analysed the structure activity relationships of its reduced (non-oxidized) form (red-MytCc). In contrast to results previously reported for oxidized isoforms of mussel myticins, red-MytCc was not active against bacteria at physiological pH and showed a moderate antiviral activity against the viral haemorrhagic septicaemia (VHS) rhabdovirus. However, its chemotactic properties remained active. Structure/function studies in neutral and acid environments by means of infrared spectroscopy indicated that the structure of red-MytCc is pH dependent, with acid media increasing its alpha-helical content. Furthermore, red-MytCc was able to efficiently aggregate artificial phospholipid membranes at low pH, as well as to inhibit the Escherichia coli growth, suggesting that this activity is attributable to its more structured form in an acidic environment. All together, these results highlight the dynamic and environmentally sensitive behavior of red-Myt C in solution, and provide important insights into Myt C structure/activity relationships and the requirements to exert its antimicrobial/immunomodulatory activities. On the other hand, the pH-dependent direct antimicrobial activity of Myt C suggests that this HDP may be a suitable template for the development of antimicrobial agents that would function selectively in specific pH environments, which are sorely needed in this “antibiotic-resistance era”. PMID:23880927

Energy materials coordinating committee (EMaCC). Annual technical report, fiscal year 2005

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2006-09-29

The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. Topical subcommittees of the EMaCC are responsible for conducting seminars and otherwise facilitating information flow between DOE organizational units in materials areas of particular importance to the Department. The EMaCCmore » Terms of Reference were recently modified and developed into a Charter that was approved on June 5, 2003. As a result of this reorganization, the existing subcommittees were disbanded and new subcommittees are being formed. The FY 2004 budget summary for DOE Materials Activities is presented on page 8. The distribution of these funds between DOE laboratories, private industry, academia and other organizations is presented in tabular form on page 10. Following the budget summary is a set of detailed program descriptions for the FY 2004 DOE Materials activities. These descriptions are presented according to the organizational structure of the Department. A mission statement, a budget summary listing the project titles and FY 2004 funding, and detailed project summaries are presented for each Assistant Secretary office, the Office of Science, and the National Nuclear Security Administration. The project summaries also provide DOE, laboratory, academic and industrial contacts for each project, as appropriate.« less

Energy materials coordinating committee (EMaCC). Annual technical report, fiscal year 2004

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2005-08-31

The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. Topical subcommittees of the EMaCC are responsible for conducting seminars and otherwise facilitating information flow between DOE organizational units in materials areas of particular importance to the Department. The EMaCCmore » Terms of Reference were recently modified and developed into a Charter that was approved on June 5, 2003. As a result of this reorganization, the existing subcommittees were disbanded and new subcommittees are being formed. The FY 2004 budget summary for DOE Materials Activities is presented on page 8. The distribution of these funds between DOE laboratories, private industry, academia and other organizations is presented in tabular form on page 10. Following the budget summary is a set of detailed program descriptions for the FY 2004 DOE Materials activities. These descriptions are presented according to the organizational structure of the Department. A mission statement, a budget summary listing the project titles and FY 2004 funding, and detailed project summaries are presented for each Assistant Secretary office, the Office of Science, and the National Nuclear Security Administration. The project summaries also provide DOE, laboratory, academic and industrial contacts for each project, as appropriate.« less

Department of the Air Force Justification of Estimates for Fiscal Year 1981, Submitted to Congress January 1980, Aircraft Procurement, Air Force, Missile Procurement, Air Force, Other Procurement, Air Force.

DTIC Science & Technology

1980-01-01

10-0 6 EL4 -022 8L LLý 0 0 a 0 CLcc - 3 E CL 0 ;i *1 XO go10 ,* . , -8 rt -C CL.* L. OLc L ’i go 0 0 0 L +1%- 00 00I :) I.- I - - 51 .0 Cc a,,0 c0...of Test Cells M34 and M35. The bldg will be a prefabri- cated steel structure with several work stations. The work stations will have hoist systems...mate/demate the engine to its mount. The work stations will incorporate cell type interfaces for a limited checkout of engine in- strumentation. These

CHL1, ITGB3 and SLC6A4 gene expression and antidepressant drug response: results from the Munich Antidepressant Response Signature (MARS) study.

PubMed

Probst-Schendzielorz, Kristina; Scholl, Catharina; Efimkina, Olga; Ersfeld, Eva; Viviani, Roberto; Serretti, Alessandro; Fabbri, Chiara; Gurwitz, David; Lucae, Susanne; Ising, Marcus; Paul, Anna Maria; Lehmann, Marie-Louise; Steffens, Michael; Crisafulli, Concetta; Calabrò, Marco; Holsboer, Florian; Stingl, Julia

2015-01-01

The identification of antidepressant drugs (ADs) response biomarkers in depression is of high clinical importance. We explored CHL1 and ITGB3 expression as tentative response biomarkers. In vitro sensitivity to ADs, as well as gene expression and genetic variants of the candidate genes CHL1, ITGB3 and SLC6A4 were measured in lymphoblastoid cell lines (LCLs) of 58 depressed patients. An association between the clinical remission of depression and the basal expression of CHL1 and ITGB3 was discovered. Individuals whose LCLs expressed higher levels of CHL1 or ITGB3 showed a significantly better remission upon AD treatment. In addition individuals with the CHL1 rs1516338 TT genotype showed a significantly better remission after 5 weeks AD treatment than those carrying a CC genotype. No association between the in vitro sensitivity of LCLs toward AD and the clinical remission could be detected. CHL1 expression in patient-derived LCLs correlated with the clinical outcome. Thus, it could be a valid biomarker to predict the success of an antidepressant therapy. Original submitted 8 December 2014; Revision submitted 2 March 2015.

A Gene Module-Based eQTL Analysis Prioritizing Disease Genes and Pathways in Kidney Cancer.

PubMed

Yang, Mary Qu; Li, Dan; Yang, William; Zhang, Yifan; Liu, Jun; Tong, Weida

2017-01-01

Clear cell renal cell carcinoma (ccRCC) is the most common and most aggressive form of renal cell cancer (RCC). The incidence of RCC has increased steadily in recent years. The pathogenesis of renal cell cancer remains poorly understood. Many of the tumor suppressor genes, oncogenes, and dysregulated pathways in ccRCC need to be revealed for improvement of the overall clinical outlook of the disease. Here, we developed a systems biology approach to prioritize the somatic mutated genes that lead to dysregulation of pathways in ccRCC. The method integrated multi-layer information to infer causative mutations and disease genes. First, we identified differential gene modules in ccRCC by coupling transcriptome and protein-protein interactions. Each of these modules consisted of interacting genes that were involved in similar biological processes and their combined expression alterations were significantly associated with disease type. Then, subsequent gene module-based eQTL analysis revealed somatic mutated genes that had driven the expression alterations of differential gene modules. Our study yielded a list of candidate disease genes, including several known ccRCC causative genes such as BAP1 and PBRM1 , as well as novel genes such as NOD2, RRM1, CSRNP1, SLC4A2, TTLL1 and CNTN1. The differential gene modules and their driver genes revealed by our study provided a new perspective for understanding the molecular mechanisms underlying the disease. Moreover, we validated the results in independent ccRCC patient datasets. Our study provided a new method for prioritizing disease genes and pathways.

Cross cultural comparison of constipation profiles at tertiary care centers between India and USA.

PubMed

Singh, P; Surana, R; Soni, S; Agnihotri, A; Ahuja, V; Makharia, G K; Staller, K; Kuo, B

2018-03-09

Despite potential differences in patient perception of chronic constipation (CC) in geographically and culturally distinct regions, head-to-head studies comparing the clinical profile, constipation severity, impact on quality of life (QOL) and economic impact are lacking. We conducted a cross-sectional cohort study of patients presenting with CC to tertiary care centers in the USA and India. Standardized instruments were used to assess constipation subtype, disease severity, disease-specific QOL, somatization, and psychiatric comorbidities. We used multivariable linear regression to determine the predictors of QOL and number of healthcare visits. Sixty-six and 98 patients with CC were enrolled in the USA and India, respectively. Indian patients with CC had significantly more frequent bowel movements/week compared to their USA counterparts (Median 5 vs 3, P < .0001). The proportion of patients with Bristol stool form scale type 1 and 2 was significantly higher in the USA compared to India (65.5% vs 48%, P = .04). Higher depression score (P = .001), more severe constipation symptoms (P = .001) and site of the study being USA (P = .008) independently predicted worse QOL. Indian patients (P < .001) and worse QOL (P = .02) were independent predictors of number of healthcare visits in the last 12 months. Indian patients with CC have more frequent and softer bowel movements compared to those in the USA suggesting significant differences in perception of CC in different geographic and cultural settings. QOL and economic impact related to constipation varies with geographic/cultural setting irrespective of other clinical and psychosomatic features. © 2018 John Wiley & Sons Ltd.

21 CFR 1271.22 - How and where do I register and submit an HCT/P list?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false How and where do I register and submit an HCT/P... Listing § 1271.22 How and where do I register and submit an HCT/P list? (a) You must use Form FDA 3356 for: (1) Establishment registration, (2) HCT/P listings, and (3) Updates of registration and HCT/P listing...

Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis

PubMed Central

2011-01-01

Background Pulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors. Previous studies have demonstrated conflicting results with regard to the associations of these chemokines with sarcoidosis. In an effort to clarify previous discrepancies, we performed the largest observational study to date of CC chemokines in bronchoalveolar lavage fluid (BALF) from patients with pulmonary sarcoidosis. Results BALF chemokine levels from 72 patients affected by pulmonary sarcoidosis were analyzed by enzyme-linked immunosorbent assay (ELISA) and compared to 8 healthy volunteers. BALF CCL3 and CCL4 levels from pulmonary sarcoidosis patients were not increased compared to controls. However, CCL2 and CCL5 levels were elevated, and subgroup analysis showed higher levels of both chemokines in all stages of pulmonary sarcoidosis. CCL2, CCL5, CC chemokine receptor type 1 (CCR1), CCR2 and CCR3 were expressed from mononuclear cells forming the lung granulomas, while CCR5 was only found on mast cells. Conclusions These data suggest that CCL2 and CCL5 are important mediators in recruiting CCR1, CCR2, and CCR3 expressing mononuclear cells as well as CCR5-expressing mast cells during all stages of pulmonary sarcoidosis. PMID:21463523

Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis.

PubMed

Palchevskiy, Vyacheslav; Hashemi, Nastran; Weigt, Stephen S; Xue, Ying Ying; Derhovanessian, Ariss; Keane, Michael P; Strieter, Robert M; Fishbein, Michael C; Deng, Jane C; Lynch, Joseph P; Elashoff, Robert; Belperio, John A

2011-04-04

Pulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors. Previous studies have demonstrated conflicting results with regard to the associations of these chemokines with sarcoidosis. In an effort to clarify previous discrepancies, we performed the largest observational study to date of CC chemokines in bronchoalveolar lavage fluid (BALF) from patients with pulmonary sarcoidosis. BALF chemokine levels from 72 patients affected by pulmonary sarcoidosis were analyzed by enzyme-linked immunosorbent assay (ELISA) and compared to 8 healthy volunteers. BALF CCL3 and CCL4 levels from pulmonary sarcoidosis patients were not increased compared to controls. However, CCL2 and CCL5 levels were elevated, and subgroup analysis showed higher levels of both chemokines in all stages of pulmonary sarcoidosis. CCL2, CCL5, CC chemokine receptor type 1 (CCR1), CCR2 and CCR3 were expressed from mononuclear cells forming the lung granulomas, while CCR5 was only found on mast cells. These data suggest that CCL2 and CCL5 are important mediators in recruiting CCR1, CCR2, and CCR3 expressing mononuclear cells as well as CCR5-expressing mast cells during all stages of pulmonary sarcoidosis.

Smart Construction of Integrated CNTs/Li4Ti5O12 Core/Shell Arrays with Superior High-Rate Performance for Application in Lithium-Ion Batteries.

PubMed

Yao, Zhujun; Xia, Xinhui; Zhou, Cheng-Ao; Zhong, Yu; Wang, Yadong; Deng, Shengjue; Wang, Weiqi; Wang, Xiuli; Tu, Jiangping

2018-03-01

Exploring advanced high-rate anodes is of great importance for the development of next-generation high-power lithium-ion batteries (LIBs). Here, novel carbon nanotubes (CNTs)/Li 4 Ti 5 O 12 (LTO) core/shell arrays on carbon cloth (CC) as integrated high-quality anode are constructed via a facile combined chemical vapor deposition-atomic layer deposition (ALD) method. ALD-synthesized LTO is strongly anchored on the CNTs' skeleton forming core/shell structures with diameters of 70-80 nm the combined advantages including highly conductive network, large surface area, and strong adhesion are obtained in the CC-LTO@CNTs core/shell arrays. The electrochemical performance of the CC-CNTs/LTO electrode is completely studied as the anode of LIBs and it shows noticeable high-rate capability (a capacity of 169 mA h g -1 at 1 C and 112 mA h g -1 at 20 C), as well as a stable cycle life with a capacity retention of 86% after 5000 cycles at 10 C, which is much better than the CC-LTO counterpart. Meanwhile, excellent cycling stability is also demonstrated for the full cell with LiFePO 4 cathode and CC-CNTs/LTO anode (87% capacity retention after 1500 cycles at 10 C). These positive features suggest their promising application in high-power energy storage areas.

Novel strategy to implement active-space coupled-cluster methods

NASA Astrophysics Data System (ADS)

Rolik, Zoltán; Kállay, Mihály

2018-03-01

A new approach is presented for the efficient implementation of coupled-cluster (CC) methods including higher excitations based on a molecular orbital space partitioned into active and inactive orbitals. In the new framework, the string representation of amplitudes and intermediates is used as long as it is beneficial, but the contractions are evaluated as matrix products. Using a new diagrammatic technique, the CC equations are represented in a compact form due to the string notations we introduced. As an application of these ideas, a new automated implementation of the single-reference-based multi-reference CC equations is presented for arbitrary excitation levels. The new program can be considered as an improvement over the previous implementations in many respects; e.g., diagram contributions are evaluated by efficient vectorized subroutines. Timings for test calculations for various complete active-space problems are presented. As an application of the new code, the weak interactions in the Be dimer were studied.

E2 enzyme inhibition by stabilization of a low affinity interface with ubiquitin

PubMed Central

St-Cyr, Daniel J.; Ziemba, Amy; Garg, Pankaj; Plamondon, Serge; Auer, Manfred; Sidhu, Sachdev; Marinier, Anne; Kleiger, Gary; Tyers, Mike; Sicheri, Frank

2014-01-01

Weak protein interactions between ubiquitin and the ubiquitin-proteasome system (UPS) enzymes that mediate its covalent attachment to substrates serve to position ubiquitin for optimal catalytic transfer. We show that a small molecule inhibitor of the E2 ubiquitin conjugating enzyme Cdc34A, called CC0651, acts by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin binding site. A structure of the ternary CC0651-Cdc34A-ubiquitin complex reveals that the inhibitor engages a composite binding pocket formed from Cdc34A and ubiquitin. CC0651 also suppresses the spontaneous hydrolysis rate of the Cdc34A-ubiquitin thioester, without overtly affecting the interaction between Cdc34A and the RING domain subunit of the E3 enzyme. Stabilization of the numerous other weak interactions between ubiquitin and UPS enzymes by small molecules may be a feasible strategy to selectively inhibit different UPS activities. PMID:24316736

40 CFR 60.1860 - What reports must I submit and in what form?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Times for Small Municipal Waste Combustion Units Constructed on or Before August 30, 1999 Model Rule... §§ 60.1870, 60.1880, and 60.1895. If the Administrator agrees, you may submit electronic reports. (c...

40 CFR 60.1860 - What reports must I submit and in what form?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Times for Small Municipal Waste Combustion Units Constructed on or Before August 30, 1999 Model Rule... §§ 60.1870, 60.1880, and 60.1895. If the Administrator agrees, you may submit electronic reports. (c...

40 CFR 60.1860 - What reports must I submit and in what form?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Times for Small Municipal Waste Combustion Units Constructed on or Before August 30, 1999 Model Rule... §§ 60.1870, 60.1880, and 60.1895. If the Administrator agrees, you may submit electronic reports. (c...

40 CFR 60.1860 - What reports must I submit and in what form?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Times for Small Municipal Waste Combustion Units Constructed on or Before August 30, 1999 Model Rule... §§ 60.1870, 60.1880, and 60.1895. If the Administrator agrees, you may submit electronic reports. (c...

40 CFR 60.1860 - What reports must I submit and in what form?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Times for Small Municipal Waste Combustion Units Constructed on or Before August 30, 1999 Model Rule... §§ 60.1870, 60.1880, and 60.1895. If the Administrator agrees, you may submit electronic reports. (c...

31 CFR 256.53 - How does the submitting agency know when payment is made?

Code of Federal Regulations, 2010 CFR

2010-07-01

... form. Also, FMS maintains an on-line payment status system that the submitting agency can access to determine the status of a payment. The payment reporting system can be accessed from the Judgment Fund Web...

32 CFR 751.10 - Form of claim.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Claims Against the United States § 751.10 Form of claim. The claim should be submitted on DD Form 1842 (Claim for Personal Property) accompanied by DD Form 1844 (List of Property). If DD Forms 1842 and 1844 1...

The Effect of Anatomical Location of Lymph Node Metastases on Cancer Specific Survival in Patients with Clear Cell Renal Cell Carcinoma

PubMed Central

Nini, Alessandro; Larcher, Alessandro; Cianflone, Francesco; Trevisani, Francesco; Terrone, Carlo; Volpe, Alessandro; Regis, Federica; Briganti, Alberto; Salonia, Andrea; Montorsi, Francesco; Bertini, Roberto; Capitanio, Umberto

2018-01-01

Background Positive nodal status (pN1) is an independent predictor of survival in renal cell carcinoma (RCC) patients. However, no study to date has tested whether the location of lymph node (LN) metastases does affect oncologic outcomes in a population submitted to radical nephrectomy (RN) and extended lymph node dissection (eLND). Objective To describe nodal disease dissemination in clear cell RCC (ccRCC) patients and to assess the effect of the anatomical sites and the number of nodal areas affected on cancer specific mortality (CSM). Design, setting and partecipants The study included 415 patients who underwent RN and eLND, defined as the removal of hilar, side-specific (pre/paraaortic or pre/paracaval) and interaortocaval LNs for ccRCC, at two institutions. Outcome measurement and statistical analysis Descriptive statistics were used to depict nodal dissemination in pN1 patients, stratified according to nodal site and number of involved areas. Multivariable Cox regression analyses and Kaplan-Meier curves were used to explore the relationship between pN1 disease features and survival outcomes. Results and limitations Median number of removed LN was 14 (IQR 9–19); 23% of patients were pN1. Among patients with one involved nodal site, 54 and 26% of patients were positive only in side-specific and interaortocaval station, respectively. The most frequent nodal site was the interaortocaval and side-specific one, for right and left ccRCC, respectively. Interaortocaval nodal positivity (HR 2.3, CI 95%: 1.3–3.9, p < 0.01) represented an independent predictor of CSM. Conclusions When ccRCC patient harbour nodal disease, its spreading can occur at any nodal station without involving the others. The presence of interoartocaval positive nodes does affect oncologic outcomes. Patient summary Lymph node invasion in patients with clear cell renal cell carcinoma is not following a fixed anatomical pattern. An extended lymph node dissection, during treatment for primary kidney tumour, would aid patient risk stratification and multimodality upfront treatment. PMID:29740587

75 FR 5853 - Proposed Collection; Comment Request for Form 13803

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... 13803, Income Verification Express Service Application and Employee Delegation Form. DATES: Written... Application and Employee Delegation Form. OMB Number: 1545-2032. Form Number: Form 13803. Abstract: Form 13803, Income Verification Express Service Application and Employee Delegation Form, is used to submit the...

Catalytic Carbonyl Allylation, Propargylation and Vinylation from the Alcohol or Aldehyde Oxidation Level via C-C Bond Forming Hydrogenation and Transfer Hydrogenation: A Departure from Preformed Organometallic Reagents**

PubMed Central

Bower, John F.; Kim, In Su; Patman, Ryan L.; Krische, Michael J.

2009-01-01

Classical protocols for carbonyl allylation, propargylation and vinylation typically rely upon the use of preformed allyl metal, allenyl metal and vinyl metal reagents, respectively, mandating stoichiometric generation of metallic byproducts. Through transfer hydrogenative C-C coupling, carbonyl addition may be achieved from the aldehyde or alcohol oxidation level in the absence of stoichiometric organometallic reagents or metallic reductants. Here, we review transfer hydrogenative methods for carbonyl addition, which encompass the first cataltyic protocols enabling direct C–H functionalization of alcohols. PMID:19040235

Modeling Aerosol Particle Deposition on a Person Using Computational Fluid Dynamics

DTIC Science & Technology

2015-04-03

The particle Stokes number is defined as Stk = Cc ρpUjd 2 p 9µD ’ (1) (1050) (10.5) (5× 10 −6) 2 (9) (1.824× 10−5) (0.015) = 0.112, (3.2) where Cc ’ 1...sizes (5 µm and Stk = 0.11). Therefore, the appropriate modeling of the fluid fluctuations in the near-wall region is crucial for accurate sim- ulations...direction, are summarized in Figures 4.5– 4.10. For visualization purposes, the flow fields and streamlines at two cross sections through the human form

Reactivity and Selectivity in Hydrovinylation of Strained Alkenes

PubMed Central

Liu, Wang; RajanBabu, T. V.

2010-01-01

Scope of Ni(II)-catalyzed hydrovinylation has been extended to strained alkenes such as heterobicyclic- [2.2.1]heptanes and cylobutenes. Reactions involving the heterobicyclic compounds are rare examples for this class of compounds where the metal-catalyzed C-C bond-forming reactions proceed without a concomitant ring-opening process. While the enantioselectivity in these systems remains modest, hydrovinylation of endo-5,6--bis-benzyloxymethylbicyclo[2.2.1]hept-2-ene gives excellent yield (>90%) of the product with one of the highest enantioselectivities (95–99 %ee) reported for a C-C bondforming reaction of norbornenes. PMID:20964350

75 FR 31791 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

... reveal the genetic processes occurring in ccRCC tissues that may contribute to advanced disease. Positive... transformed into blood brain barrier permeable forms by the coupling of an Inter-Cellular Adhesion Molecule-1...

Pivot/Remote: a distributed database for remote data entry in multi-center clinical trials.

PubMed

Higgins, S B; Jiang, K; Plummer, W D; Edens, T R; Stroud, M J; Swindell, B B; Wheeler, A P; Bernard, G R

1995-01-01

1. INTRODUCTION. Data collection is a critical component of multi-center clinical trials. Clinical trials conducted in intensive care units (ICU) are even more difficult because the acute nature of illnesses in ICU settings requires that masses of data be collected in a short time. More than a thousand data points are routinely collected for each study patient. The majority of clinical trials are still "paper-based," even if a remote data entry (RDE) system is utilized. The typical RDE system consists of a computer housed in the CC office and connected by modem to a centralized data coordinating center (DCC). Study data must first be recorded on a paper case report form (CRF), transcribed into the RDE system, and transmitted to the DCC. This approach requires additional monitoring since both the paper CRF and study database must be verified. The paper-based RDE system cannot take full advantage of automatic data checking routines. Much of the effort (and expense) of a clinical trial is ensuring that study data matches the original patient data. 2. METHODS. We have developed an RDE system, Pivot/Remote, that eliminates the need for paper-based CRFs. It creates an innovative, distributed database. The database resides partially at the study clinical centers (CC) and at the DCC. Pivot/Remote is descended from technology introduced with Pivot [1]. Study data is collected at the bedside with laptop computers. A graphical user interface (GUI) allows the display of electronic CRFs that closely mimic the normal paper-based forms. Data entry time is the same as for paper CRFs. Pull-down menus, displaying the possible responses, simplify the process of entering data. Edit checks are performed on most data items. For example, entered dates must conform to some temporal logic imposed by the study. Data must conform to some acceptable range of values. Calculations, such as computing the subject's age or the APACHE II score, are automatically made as the data is entered. Data that is collected serially (BP, HR, etc.) can be displayed graphically in a trend form along with other related variables. An audit trail is created that automatically tracks all changes to the original data, making it possible to reconstruct the CRF to any point in time. On-line help provides information on the study protocol as well as assistance with the use of the system. Electronic security makes it possible to lock certain parts of the CRF once it has been monitored. Completed CRFs are transmitted to the DCC via electronic mail where it is reviewed and merged into the study database. Questions about subject data are transmitted back to the CC via electronic mail. This approach to maintaining the study database is unique in that the study data files are distributed among the CC and DCC. Until a subject's CRF is monitored (verified against the original patient data residing in the hospital record), it logically resides at the CC where it was collected. Copies are transmitted to the DCC and are only read there. Any pre-monitoring changes must be made to the data at the CC. Once the subject's CRF is monitored, it logically moves to the DCC, and any subsequent changes are made at the DCC with copies of the CRF flowing back to the CC. 3. DISCUSSION. Pivot/Remote eliminates the need for paper forms by utilizing portable computers that can be used at the patient bedside. A GUI makes it possible to quickly enter data. Because the user gets instant feedback on possible error conditions, time is saved because the original data is close at hand. The ability to display trended data or variables in the context of other data allows detection of erroneous conditions beyond simple range checks. The logical construction of the database minimizes the problem of managing dual databases (at the CC and DCC) and keeps CC personnel in the loop until all changes are made.

Nanoparticle analysis for various medicinal drugs and human body saliva at macromolecular level

NASA Astrophysics Data System (ADS)

Uthayakumar, G. S.; Senthilkumar; Inbasekaran, S.; Sivasubramanian, A.; Justin Packia Jacob, S.

2015-06-01

The spectral bio-diagnosis of normal human body saliva sample shows the following functional compounds and it is related to various proteins and enzymes. Because of the presence of water in the saliva sample, the hydroxyl group is observed in the form of O-H at 3,305 cm-1, because of the presence of lipids, the functional group C-H is obtained from 2,928 to 2,856 cm-1, due to the presence of amide-I in the form of C=N and C=C obtained at 1,658 cm-1, the proteins are exhibited. Due to the presence of aliphatic CH2, the Lipids, Adenine, Cytosine, Collagen are observed at 1,455 cm-1, because of the presence of Carbohydrates, Phospholipids, Nucleic acids, the functional groups C=O and P=O from 1,159 to 1,064 cm-1 are exhibited. Due to the presence of Phenylalanine, Tyrosine, Cystine and Hydroxyapatite C-C twist, C-C stretch, C-S stretch and PO4 2- are observed at 748 and 483 cm-1. Silver nanoparticle has attracted considerable interest due to their extensive applicability in various areas such as electronics, catalysis, chemistry, energy and medicine. To study the opto-electronics properties of the samples, it was mixed with silver nanoparticles and characterized.

Establishment of cocrystal cocktail grinding method for rational screening of pharmaceutical cocrystals.

PubMed

Yamamoto, Katsuhiko; Tsutsumi, Shunichirou; Ikeda, Yukihiro

2012-11-01

Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability. Grinding is more effective for CC synthesis than crystallization from solution because in the former case, the API can predominantly interact with the CCF without being affected by solvents. However, this method is tedious because the API is ground with only one CCF at a time. We developed a cocktail cocrystal grinding (CCG) method, in which a mixture of CCFs having the same functional group was used. No false negatives/positives were observed in CCG when carbamazepine was used as the model compound. This method could be used to obtain CCs of piroxicam and spironolactone. False negatives were observed for only one compound from among three model compounds, indicating that CCG facilitates efficient CC detection and that it has higher throughput than does the conventional method. Further, CCG is fast and suitable for rational CC screening, and it helps identify the partial structure of CCFs that forms synthons with an API. Copyright © 2012 Elsevier B.V. All rights reserved.

Externally Heated Protostellar Cores in the Ophiuchus Star-Forming Region

NASA Technical Reports Server (NTRS)

Lindberg, Johan E.; Charnley, Steven B.; Jorgensen, Jes K.; Cordiner, Martin A.; Bjerkeli, Per

2017-01-01

We present APEX 218 GHz observations of molecular emission in a complete sample of embedded protostars in the Ophiuchus star-forming region. To study the physical properties of the cores, we calculate H2CO and c-C3H2 rotational temperatures, both of which are good tracers of the kinetic temperature of the molecular gas. We find that the H2CO temperatures range between 16K and 124K, with the highest H2CO temperatures toward the hot corino source IRAS 16293-2422 (69-124 K) and the sources in the rho Oph A cloud (23-49 K) located close to the luminous Herbig Be star S1, which externally irradiates the rho Oph A cores. On the other hand, the c-C3H2 rotational temperature is consistently low (7-17 K) in all sources. Our results indicate that the c-C3H2 emission is primarily tracing more shielded parts of the envelope whereas the H2CO emission (at the angular scale of the APEX beam; 3600 au in Ophiuchus) mainly traces the outer irradiated envelopes, apart from in IRAS?16293-2422, where the hot corino emission dominates. In some sources, a secondary velocity component is also seen, possibly tracing the molecular outflow.

30 CFR 1210.157 - What reports must I submit to suspend an ONRR order under appeal?

Code of Federal Regulations, 2014 CFR

2014-07-01

....S. Treasury Securities. (b) Reporting options. You must submit these forms and other documents... Internet Web site at http://www.onrr.gov/Laws_R_D/FRNotices/ICR0122.htm. (c) Reporting address. You may...

30 CFR 1210.157 - What reports must I submit to suspend an ONRR order under appeal?

Code of Federal Regulations, 2013 CFR

2013-07-01

....S. Treasury Securities. (b) Reporting options. You must submit these forms and other documents... Internet Web site at http://www.onrr.gov/Laws_R_D/FRNotices/ICR0122.htm. (c) Reporting address. You may...

48 CFR 453.108 - Recommendations concerning forms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Recommendations concerning forms. 453.108 Section 453.108 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CLAUSES AND FORMS FORMS General 453.108 Recommendations concerning forms. Contracting officers shall submit...

Rubisco activity in Mediterranean species is regulated by the chloroplastic CO2 concentration under water stress

PubMed Central

Galmés, Jeroni; Ribas-Carbó, Miquel; Medrano, Hipólito; Flexas, Jaume

2011-01-01

Water stress decreases the availability of the gaseous substrate for ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) by decreasing leaf conductance to CO2. In spite of limiting photosynthetic carbon assimilation, especially in those environments where drought is the predominant factor affecting plant growth and yield, the effects of water deprivation on the mechanisms that control Rubisco activity are unclear. In the present study, 11 Mediterranean species, representing different growth forms, were subject to increasing levels of drought stress, the most severe one followed by rewatering. The results confirmed species-specific patterns in the decrease in the initial activity and activation state of Rubisco as drought stress and leaf dehydration intensified. Nevertheless, all species followed roughly the same trend when Rubisco activity was related to stomatal conductance (gs) and chloroplastic CO2 concentration (Cc), suggesting that deactivation of Rubisco sites could be induced by low Cc, as a result of water stress. The threshold level of Cc that triggered Rubisco deactivation was dependent on leaf characteristics and was related to the maximum attained for each species under non-stressing conditions. Those species adapted to low Cc were more capable of maintaining active Rubisco as drought stress intensified. PMID:21115663

Carbon-Carbon Composite Radiator Development for the EO-1 Spacecraft

NASA Technical Reports Server (NTRS)

Vaughn, Wallace; Shinn, Elizabeth; Rawal, Suraj; Wright, Joe

2004-01-01

The Carbon-Carbon Space Radiator Partnership (CSRP), an informal partnership of Government and industrial personnel, was formed to promote the use of Carbon-carbon composites (C-C) as engineering materials for spacecraft thermal management applications . As a part of this effort the partnership has built a structural radiator for the Earth Orbiter - 1 (EO-1) spacecraft. This radiator, using C-C face-sheets with an aluminum honeycomb core, will demonstrate both the thermal and structural properties of C-C under actual service conditions as well as provide performance data from space flight. This paper will present results from the design of the radiator, the thermal/mechanical tests of the facesheet materials, and sub-component test results on the C-C/Al honeycomb sandwich material. The 29- by 28-inch radiator was designed to support two electronics boxes with a combined heat output of 60 watts maximum and a weight of 58 lbs. The analysis of the radiator design shows that the radiator constructed with 20-mil-thick facesheets of a P30-fiber-reinforced C-C from BFGoodrich is able to meet or exceed all the required thermal and mechanical requirements.

Pressure equilibration in the penguin middle ear.

PubMed

Sadé, Jacob; Handrich, Yves; Bernheim, Joelle; Cohen, David

2008-01-01

King penguins have a venous structure in the form of a corpus cavernosum (CC) in their middle ear (ME) submucosa. The CC may be viewed as a special organelle that can change ME volume for pressure equilibration during deep-sea diving it is a pressure regulating organelle (PRO). A similar CC and muscles also surround the external ear (EE) and may constrict it, isolating the tympanic membrane from the outside. A CC was previously found also in the ME of marine diving mammals and can be expected to exist in other deep diving animals, such as marine turtles. Marine animals require equalization of middle ear (ME) pressure when diving hundreds or thousands of meters to catch prey. We investigated what mechanism enables king penguins to protect their ME when they dive to great depths. Biopsies and serial sections of the ME and the EE of the deep diving king penguin (Aptenodytes patagonicus) were examined microscopically. It was demonstrated that the penguin ME has an extensive network of small and large submucosal venous sinuses. This venous formation, a corpus cavernosum, can expand and potentially 'flood' the ME almost completely on diving, thus elevating ME pressure and reducing the ME space. The EE has a similar protective mechanism.

An Investigation on Ground Electrodes of Capacitive Coupling Human Body Communication.

PubMed

Mao, Jingna; Yang, Huazhong; Zhao, Bo

2017-08-01

Utilizing the body surface as the signal transmission medium, capacitive coupling human body communication (CC-HBC) can achieve a much higher energy efficiency than conventional wireless communications in future wireless body area network (WBAN) applications. Under the CC-HBC scheme, the body surface serves as the forward signal path, whereas the backward path is formed by the capacitive coupling between the ground electrodes (GEs) of transmitter (TX) and receiver (RX). So the type of communication benefits from a low forward loss, while the backward loss depending on the GE coupling strength dominates the total transmission loss. However, none of the previous works have shown a complete research on the effects of GEs. In this paper, all kinds of GE effects on CC-HBC are investigated by both finite element method (FEM) analysis and human body measurement. We set the TX GE and RX GE at different heights, separation distances, and dimensions to study the corresponding influence on the overall signal transmission path loss. In addition, we also investigate the effects of GEs with different shapes and different TX-to-RX relative angles. Based on all the investigations, an analytical model is derived to evaluate the GE related variations of channel loss in CC-HBC.

Infrared spectra and quantum chemical calculations of the uranium-carbon molecules UC, CUC, UCH, and U(CC)2

NASA Astrophysics Data System (ADS)

Wang, Xuefeng; Andrews, Lester; Ma, Dongxia; Gagliardi, Laura; Gonçalves, António P.; Pereira, Cláudia C. L.; Marçalo, Joaquim; Godart, Claude; Villeroy, Benjamin

2011-06-01

Laser evaporation of carbon rich uranium/carbon alloy targets into condensing argon or neon matrix samples gives weak infrared absorptions that increase on annealing, which can be assigned to new uranium carbon bearing species. New bands at 827.6 cm-1 in solid argon or 871.7 cm-1 in neon become doublets with mixed carbon 12 and 13 isotopes and exhibit the 1.0381 carbon isotopic frequency ratio for the UC diatomic molecule. Another new band at 891.4 cm-1 in argon gives a three-band mixed isotopic spectrum with the 1.0366 carbon isotopic frequency ratio, which is characteristic of the anti-symmetric stretching vibration of a linear CUC molecule. No evidence was found for the lower energy cyclic U(CC) isomer. Other bands at 798.6 and 544.0 cm-1 are identified as UCH, which has a uranium-carbon triple bond similar to that in UC. Evidence is found for bicyclic U(CC)2 and tricyclic U(CC)3. This work shows that U and C atoms react spontaneously to form the uranium carbide U≡C and C≡U≡C molecules with uranium-carbon triple bonds.

7 CFR 622.20 - Application.

Code of Federal Regulations, 2010 CFR

2010-01-01

... forms for Federal assistance or other approved forms may be obtained from NRCS State, area, or field offices. These forms should be submitted to the Single Point of Contact in accordance with the State...

Science as Play

ERIC Educational Resources Information Center

Raymo, Chester

1973-01-01

Analyzes the nature and characteristics of the scientific endeavor to compare with that of children's play. Describes science as a form of religious sacred play which creates a world of make-believe that one may enter if one chooses to play. (CC)

CLEAN CHEMICAL SYNTHESIS IN WATER

EPA Science Inventory

Newer green chemistry approach to accomplish chemical synthesis in water is summarized. Recent global developments pertaining to C-C bond forming reactions using metallic reagents and direct use of the renewable materials such as carbohydrates without derivatization are described...

76 FR 60127 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... plan administrators will use these forms to submit requests of; changes to their account information... Department of the Treasury will submit the following public information collection requirements to OMB for... Officer listed. Comments regarding these information collections should be addressed to the OMB reviewer...

77 FR 28386 - Information Collection Being Submitted for Review and Approval to the Office of Management and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

... FEDERAL COMMUNICATIONS COMMISSION Information Collection Being Submitted for Review and Approval... respondents, including the use of automated collection techniques or other forms of information technology... information collection requirements remain pending. Federal Communications Commission. Marlene H. Dortch...

CD47-ligation induced cell death in T-acute lymphoblastic leukemia.

PubMed

Leclair, Pascal; Liu, Chi-Chao; Monajemi, Mahdis; Reid, Gregor S; Sly, Laura M; Lim, Chinten James

2018-05-10

CD47 is a cell-surface marker well recognized for its anti-phagocytic functions. As such, an emerging avenue for targeted cancer therapies involves neutralizing the anti-phagocytic function using monoclonal antibodies (mAbs) to enhance tumour cell immunogenicity. A lesser known consequence of CD47 receptor ligation is the direct induction of tumour cell death. While several mAbs and their derivatives with this property have been studied, the best characterized is the commercially available mAb B6H12, which requires immobilization for induction of cell death. Here, we describe a commercially available mAb, CC2C6, which induces T-cell acute lymphoblastic leukemia (ALL) cell death in soluble form. Soluble CC2C6 induces CD47-dependent cell death in a manner consistent with immobilized B6H12, which is characterized by mitochondrial deficiencies but is independent of caspase activation. Titration studies indicated that CC2C6 shares a common CD47-epitope with B6H12. Importantly, CC2C6 retains the anti-phagocytic neutralizing function, thus possessing dual anti-tumour properties. Although CD47-ligation induced cell death occurs in a caspase-independent manner, CC2C6 was found to stimulate increases in Mcl-1 and NOXA levels, two Bcl-2 family proteins that govern the intrinsic apoptosis pathway. Further analysis revealed that the ratio of Mcl-1:NOXA were minimally altered for cells treated with CC2C6, in comparison to cells treated with agents that induced caspase-dependent apoptosis which alter this ratio in favour of NOXA. Finally, we found that CC2C6 can synergize with low dose chemotherapeutic agents that induce classical apoptosis, giving rise to the possibility of an effective combination treatment with reduced long-term sequelae associated with high-dose chemotherapies in childhood ALL.

Convergence of Cortical, Thalamocortical, and Callosal Pathways during Human Fetal Development Revealed by Diffusion MRI Tractography.

PubMed

Wang, Rongpin; Wilkinson, Molly; Kane, Tara; Takahashi, Emi

2017-01-01

There has been evidence that during brain development, emerging thalamocortical (TC) and corticothalamic (CT) pathways converge in some brain regions and follow each other's trajectories to their final destinations. Corpus callosal (CC) pathways also emerge at a similar developmental stage, and are known to converge with TC pathways in specific cortical regions in mature brains. Given the functional relationships between TC and CC pathways, anatomical convergence of the two pathways are likely important for their functional integration. However, it is unknown (1) where TC and CT subcortically converge in the human brain, and (2) where TC and CC converge in the cortex of the human brain, due to the limitations of non-invasive methods. The goals of this study were to describe the spatio-temporal relationships in the development of the TC/CT and CC pathways in the human brain, using high-angular resolution diffusion MR imaging (HARDI) tractography. Emerging cortical, TC and CC pathways were identified in postmortem fetal brains ranging from 17 gestational weeks (GW) to 30 GW, as well as in vivo 34-40 GW newborns. Some pathways from the thalami were found to be converged with pathways from the cerebral cortex as early as 17 GW. Such convergence was observed mainly in anterior and middle regions of the brain until 21 GW. At 22 GW and onwards, posterior pathways from the thalami also converged with cortical pathways. Many CC pathways reached the full length up to the cortical surface as early as 17 GW, while pathways linked to thalami (not only TC axons but also including pathways linked to thalamic neuronal migration) reached the cortical surface at and after 20 GW. These results suggest that CC pathways developed earlier than the TC pathways. The two pathways were widespread at early stages, but by 40 GW they condensed and formed groups of pathways that projected to specific regions of the cortex and overlapped in some brain regions. These results suggest that HARDI tractography has the potential to identify developing TC/CT and CC pathways with the timing and location of their convergence in fetal stages persisting in postnatal development.

Convergence of Cortical, Thalamocortical, and Callosal Pathways during Human Fetal Development Revealed by Diffusion MRI Tractography

PubMed Central

Wang, Rongpin; Wilkinson, Molly; Kane, Tara; Takahashi, Emi

2017-01-01

There has been evidence that during brain development, emerging thalamocortical (TC) and corticothalamic (CT) pathways converge in some brain regions and follow each other's trajectories to their final destinations. Corpus callosal (CC) pathways also emerge at a similar developmental stage, and are known to converge with TC pathways in specific cortical regions in mature brains. Given the functional relationships between TC and CC pathways, anatomical convergence of the two pathways are likely important for their functional integration. However, it is unknown (1) where TC and CT subcortically converge in the human brain, and (2) where TC and CC converge in the cortex of the human brain, due to the limitations of non-invasive methods. The goals of this study were to describe the spatio-temporal relationships in the development of the TC/CT and CC pathways in the human brain, using high-angular resolution diffusion MR imaging (HARDI) tractography. Emerging cortical, TC and CC pathways were identified in postmortem fetal brains ranging from 17 gestational weeks (GW) to 30 GW, as well as in vivo 34–40 GW newborns. Some pathways from the thalami were found to be converged with pathways from the cerebral cortex as early as 17 GW. Such convergence was observed mainly in anterior and middle regions of the brain until 21 GW. At 22 GW and onwards, posterior pathways from the thalami also converged with cortical pathways. Many CC pathways reached the full length up to the cortical surface as early as 17 GW, while pathways linked to thalami (not only TC axons but also including pathways linked to thalamic neuronal migration) reached the cortical surface at and after 20 GW. These results suggest that CC pathways developed earlier than the TC pathways. The two pathways were widespread at early stages, but by 40 GW they condensed and formed groups of pathways that projected to specific regions of the cortex and overlapped in some brain regions. These results suggest that HARDI tractography has the potential to identify developing TC/CT and CC pathways with the timing and location of their convergence in fetal stages persisting in postnatal development. PMID:29163000

78 FR 44119 - Information Collections Being Submitted for Review and Approval to the Office of Management and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-23

...: 3060-0874. Title: FCC Form 2000 A through H, FCC Form RDA, FCC Form 475-B, FCC Form 1088 A through H...: FCC Form 2000 A through H, FCC Form RDA, FCC Form 475- B, FCC Form 1088 A through H, and FCC Form 501...

A comparative overview of the sperm centriolar complex in mammals and birds: Variations on a theme.

PubMed

Soley, John T

2016-06-01

This paper presents an overview of the structure, function and anomalies of the sperm centriolar complex (CC) on a comparative basis between mammals and birds. The information is based on selected references from the literature supplemented by original observations on spermiogenesis and sperm structure in disparate mammalian (cheetah and cane rat) and avian (ostrich, rhea and emu) species. Whereas the basic structure of the CC (a diplosome surrounded by pericentriolar material) is similar in Aves and Mammalia, certain differences are apparent. Centriole reduction does not generally occur in birds, but when present as in oscines, involves the loss of the proximal centriole. In ratites, the distal centriole forms the core of the entire midpiece and incorporates the outer dense fibres in addition to initiating axoneme formation. The elements of the connecting piece are not segmented in birds and less complex in basic design than in mammals. The functions of the various components of the CC appear to be similar in birds and mammals. Despite obvious differences in sperm head shape, the centrosomal anomalies afflicting both vertebrate groups demonstrate structural uniformity across species and display a similar range of defects. Most abnormalities result from defective migration and alignment of the CC relative to the nucleus. The most severe manifestation is that of acephalic sperm, while angled tail attachment, abaxial and multiflagellate sperm reflect additional defective forms. The stump-tail defect is not observed in birds. A comparison of defective sperm formation and centrosomal dysfunction at the molecular level is currently difficult owing to the paucity of relevant information on avian sperm. Copyright © 2016 Elsevier B.V. All rights reserved.

Tile drainage phosphorus loss with long-term consistent cropping systems and fertilization.

PubMed

Zhang, T Q; Tan, C S; Zheng, Z M; Drury, C F

2015-03-01

Phosphorus (P) loss in tile drainage water may vary with agricultural practices, and the impacts are often hard to detect with short-term studies. We evaluated the effects of long-term (≥43 yr) cropping systems (continuous corn [CC], corn-oats-alfalfa-alfalfa rotation [CR], and continuous grass [CS]) and fertilization (fertilization [F] vs. no-fertilization [NF]) on P loss in tile drainage water from a clay loam soil over a 4-yr period. Compared with NF, long-term fertilization increased concentrations and losses of dissolved reactive P (DRP), dissolved unreactive P (DURP), and total P (TP) in tile drainage water, with the increments following the order: CS > CR > CC. Dissolved P (dissolved reactive P [DRP] and dissolved unreactive P [DURP]) was the dominant P form in drainage outflow, accounting for 72% of TP loss under F-CS, whereas particulate P (PP) was the major form of TP loss under F-CC (72%), F-CR (62%), NF-CS (66%), NF-CC (74%), and NF-CR (72%). Dissolved unreactive P played nearly equal roles as DRP in P losses in tile drainage water. Stepwise regression analysis showed that the concentration of P (DRP, DURP, and PP) in tile drainage flow, rather than event flow volume, was the most important factor contributing to P loss in tile drainage water, although event flow volume was more important in PP loss than in dissolved P loss. Continuous grass significantly increased P loss by increasing P concentration and flow volume of tile drainage water, especially under the fertilization treatment. Long-term grasslands may become a significant P source in tile-drained systems when they receive regular P addition. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

48 CFR 453.108 - Recommendations concerning forms.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Recommendations concerning... AND FORMS FORMS General 453.108 Recommendations concerning forms. Contracting officers shall submit recommendations for new forms or to revise, eliminate, or consolidate forms prescribed by FAR part 53 and part 453...

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma.

PubMed

Miess, Heike; Dankworth, Beatrice; Gouw, Arvin M; Rosenfeldt, Mathias; Schmitz, Werner; Jiang, Ming; Saunders, Becky; Howell, Michael; Downward, Julian; Felsher, Dean W; Peck, Barrie; Schulze, Almut

2018-06-05

Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Here we investigated metabolic dependencies in a panel of ccRCC cell lines using nutrient depletion, functional RNAi screening and inhibitor treatment. We found that ccRCC cells are highly sensitive to the depletion of glutamine or cystine, two amino acids required for glutathione (GSH) synthesis. Moreover, silencing of enzymes of the GSH biosynthesis pathway or glutathione peroxidases, which depend on GSH for the removal of cellular hydroperoxides, selectively reduced viability of ccRCC cells but did not affect the growth of non-malignant renal epithelial cells. Inhibition of GSH synthesis triggered ferroptosis, an iron-dependent form of cell death associated with enhanced lipid peroxidation. VHL is a major tumour suppressor in ccRCC and loss of VHL leads to stabilisation of hypoxia inducible factors HIF-1α and HIF-2α. Restoration of functional VHL via exogenous expression of pVHL reverted ccRCC cells to an oxidative metabolism and rendered them insensitive to the induction of ferroptosis. VHL reconstituted cells also exhibited reduced lipid storage and higher expression of genes associated with oxidiative phosphorylation and fatty acid metabolism. Importantly, inhibition of β-oxidation or mitochondrial ATP-synthesis restored ferroptosis sensitivity in VHL reconstituted cells. We also found that inhibition of GSH synthesis blocked tumour growth in a MYC-dependent mouse model of renal cancer. Together, our data suggest that reduced fatty acid metabolism due to inhibition of β-oxidation renders renal cancer cells highly dependent on the GSH/GPX pathway to prevent lipid peroxidation and ferroptotic cell death.

The Chloroplastic Protein THF1 Interacts with the Coiled-Coil Domain of the Disease Resistance Protein N′ and Regulates Light-Dependent Cell Death1[OPEN

PubMed Central

Sekine, Ken-Taro; Wallon, Thérèse; Sugiwaka, Yuji; Kobayashi, Kappei

2016-01-01

One branch of plant immunity is mediated through nucleotide-binding/Leu-rich repeat (NB-LRR) family proteins that recognize specific effectors encoded by pathogens. Members of the I2-like family constitute a well-conserved subgroup of NB-LRRs from Solanaceae possessing a coiled-coil (CC) domain at their N termini. We show here that the CC domains of several I2-like proteins are able to induce a hypersensitive response (HR), a form of programmed cell death associated with disease resistance. Using yeast two-hybrid screens, we identified the chloroplastic protein Thylakoid Formation1 (THF1) as an interacting partner for several I2-like CC domains. Co-immunoprecipitations and bimolecular fluorescence complementation assays confirmed that THF1 and I2-like CC domains interact in planta and that these interactions take place in the cytosol. Several HR-inducing I2-like CC domains have a negative effect on the accumulation of THF1, suggesting that the latter is destabilized by active CC domains. To confirm this model, we investigated N′, which recognizes the coat protein of most Tobamoviruses, as a prototypical member of the I2-like family. Transient expression and gene silencing data indicated that THF1 functions as a negative regulator of cell death and that activation of full-length N′ results in the destabilization of THF1. Consistent with the known function of THF1 in maintaining chloroplast homeostasis, we show that the HR induced by N′ is light-dependent. Together, our results define, to our knowledge, novel molecular mechanisms linking light and chloroplasts to the induction of cell death by a subgroup of NB-LRR proteins. PMID:26951433

Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia.

PubMed

Marzetti, Emanuele; Lorenzi, Maria; Landi, Francesco; Picca, Anna; Rosa, Fausto; Tanganelli, Fabiana; Galli, Marco; Doglietto, Giovanni Battista; Pacelli, Fabio; Cesari, Matteo; Bernabei, Roberto; Calvani, Riccardo; Bossola, Maurizio

2017-01-01

Mitochondrial dysfunction is involved in the loss of muscle featuring both aging and cancer cachexia (CC). Whether mitochondrial quality control (MQC) is altered in skeletal myocytes of old patients with CC is unclear. The present investigation therefore sought to preliminarily characterize MQC pathways in muscle of old gastric cancer patients with cachexia. The study followed a case-control cross-sectional design. Intraoperative biopsies of the rectus abdominis muscle were obtained from 18 patients with gastric adenocarcinoma (nine with CC and nine non-cachectic) and nine controls, and assayed for the expression of a set of MQC mediators. The mitofusin 2 expression was reduced in cancer patients compared with controls, independent of CC. Fission protein 1 was instead up-regulated in CC patients relative to the other groups. The mitophagy regulators PTEN-induced putative kinase 1 and Parkin were both down-regulated in cancer patients compared with controls. The ratio between the protein content of the lipidated and non-lipidated forms of microtubule-associated protein 1 light chain 3B was lower in CC patients relative to controls and non-cachectic cancer patients. Finally, the expression of autophagy-associated protein 7, lysosome-associated membrane protein 2, peroxisome proliferator-activated receptor-γ coactivator-1α, and mitochondrial transcription factor A was unvarying among groups. Collectively, our findings indicate that, in old patients with gastric cancer, cachexia is associated with derangements of the muscular MQC axis at several checkpoints: mitochondrial dynamics, mitochondrial tagging for disposal, and mitophagy signaling. Further investigations are needed to corroborate these preliminary findings and determine whether MQC pathways may become target for future interventions. Copyright © 2016 Elsevier Inc. All rights reserved.

Bigdata Driven Cloud Security: A Survey

NASA Astrophysics Data System (ADS)

Raja, K.; Hanifa, Sabibullah Mohamed

2017-08-01

Cloud Computing (CC) is a fast-growing technology to perform massive-scale and complex computing. It eliminates the need to maintain expensive computing hardware, dedicated space, and software. Recently, it has been observed that massive growth in the scale of data or big data generated through cloud computing. CC consists of a front-end, includes the users’ computers and software required to access the cloud network, and back-end consists of various computers, servers and database systems that create the cloud. In SaaS (Software as-a-Service - end users to utilize outsourced software), PaaS (Platform as-a-Service-platform is provided) and IaaS (Infrastructure as-a-Service-physical environment is outsourced), and DaaS (Database as-a-Service-data can be housed within a cloud), where leading / traditional cloud ecosystem delivers the cloud services become a powerful and popular architecture. Many challenges and issues are in security or threats, most vital barrier for cloud computing environment. The main barrier to the adoption of CC in health care relates to Data security. When placing and transmitting data using public networks, cyber attacks in any form are anticipated in CC. Hence, cloud service users need to understand the risk of data breaches and adoption of service delivery model during deployment. This survey deeply covers the CC security issues (covering Data Security in Health care) so as to researchers can develop the robust security application models using Big Data (BD) on CC (can be created / deployed easily). Since, BD evaluation is driven by fast-growing cloud-based applications developed using virtualized technologies. In this purview, MapReduce [12] is a good example of big data processing in a cloud environment, and a model for Cloud providers.

Effect of Interface Modified by Graphene on the Mechanical and Frictional Properties of Carbon/Graphene/Carbon Composites

PubMed Central

Yang, Wei; Luo, Ruiying; Hou, Zhenhua

2016-01-01

In this work, we developed an interface modified by graphene to simultaneously improve the mechanical and frictional properties of carbon/graphene/carbon (C/G/C) composite. Results indicated that the C/G/C composite exhibits remarkably improved interfacial bonding mode, static and dynamic mechanical performance, thermal conductivity, and frictional properties in comparison with those of the C/C composite. The weight contents of carbon fibers, graphene and pyrolytic carbon are 31.6, 0.3 and 68.1 wt %, respectively. The matrix of the C/G/C composite was mainly composed of rough laminar (RL) pyrocarbon. The average hardness by nanoindentation of the C/G/C and C/C composite matrices were 0.473 and 0.751 GPa, respectively. The flexural strength (three point bending), interlaminar shear strength (ILSS), interfacial debonding strength (IDS), internal friction and storage modulus of the C/C composite were 106, 10.3, 7.6, 0.038 and 12.7 GPa, respectively. Those properties of the C/G/C composite increased by 76.4%, 44.6%, 168.4% and 22.8%, respectively, and their internal friction decreased by 42.1% in comparison with those of the C/C composite. Owing to the lower hardness of the matrix, improved fiber/matrix interface bonding strength, and self-lubricating properties of graphene, a complete friction film was easily formed on the friction surface of the modified composite. Compared with the C/C composite, the C/G/C composite exhibited stable friction coefficients and lower wear losses at simulating air-plane normal landing (NL) and rejected take-off (RTO). The method appears to be a competitive approach to improve the mechanical and frictional properties of C/C composites simultaneously. PMID:28773613

48 CFR 2452.239-70 - Background investigations for sensitive automated systems/applications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CLAUSES AND FORMS SOLICITATION PROVISIONS AND..., the contractor shall submit the following completed forms: Standard Form (SF) 85P, Questionnaire for...

48 CFR 2452.239-70 - Background investigations for sensitive automated systems/applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CLAUSES AND FORMS SOLICITATION PROVISIONS AND..., the contractor shall submit the following completed forms: Standard Form (SF) 85P, Questionnaire for...

The direct arylation of allylic sp3 C-H bonds via organic and photoredox catalysis

NASA Astrophysics Data System (ADS)

Cuthbertson, James D.; MacMillan, David W. C.

2015-03-01

The direct functionalization of unactivated sp3 C-H bonds is still one of the most challenging problems facing synthetic organic chemists. The appeal of such transformations derives from their capacity to facilitate the construction of complex organic molecules via the coupling of simple and otherwise inert building blocks, without introducing extraneous functional groups. Despite notable recent efforts, the establishment of general and mild strategies for the engagement of sp3 C-H bonds in C-C bond forming reactions has proved difficult. Within this context, the discovery of chemical transformations that are able to directly functionalize allylic methyl, methylene and methine carbons in a catalytic manner is a priority. Although protocols for direct oxidation and amination of allylic C-H bonds (that is, C-H bonds where an adjacent carbon is involved in a C = C bond) have become widely established, the engagement of allylic substrates in C-C bond forming reactions has thus far required the use of pre-functionalized coupling partners. In particular, the direct arylation of non-functionalized allylic systems would enable access to a series of known pharmacophores (molecular features responsible for a drug's action), though a general solution to this long-standing challenge remains elusive. Here we report the use of both photoredox and organic catalysis to accomplish a mild, broadly effective direct allylic C-H arylation. This C-C bond forming reaction readily accommodates a broad range of alkene and electron-deficient arene reactants, and has been used in the direct arylation of benzylic C-H bonds.

Topology of charge density of flucytosine and related molecules and characteristics of their bond charge distributions.

PubMed

Murgich, Juan; Franco, Héctor J; San-Blas, Gioconda

2006-08-24

The molecular charge distribution of flucytosine (4-amino-5-fluoro-2-pyrimidone), uracil, 5-fluorouracil, and thymine was studied by means of density functional theory calculations (DFT). The resulting distributions were analyzed by means of the atoms in molecules (AIM) theory. Bonds were characterized through vectors formed with the charge density value, its Laplacian, and the bond ellipticity calculated at the bond critical point (BCP). Within each set of C=O, C-H, and N-H bonds, these vectors showed little dispersion. C-C bonds formed three different subsets, one with a significant degree of double bonding, a second corresponding to single bonds with a finite ellipticity produced by hyperconjugation, and a third one formed by a pure single bond. In N-C bonds, a decrease in bond length (an increase in double bond character) was not reflected as an increase in their ellipticity, as in all C-C bonds studied. It was also found that substitution influenced the N-C, C-O, and C-C bond ellipticity much more than density and its Laplacian at the BCP. The Laplacian of charge density pointed to the existence of both bonding and nonbonding maxima in the valence shell charge concentration of N, O, and F, while only bonding ones were found for the C atoms. The nonbonding maxima related to the sites for electrophilic attack and H bonding in O and N, while sites of nucleophilic attack were suggested by the holes in the valence shell of the C atoms of the carbonyl groups.

The direct arylation of allylic sp(3) C-H bonds via organic and photoredox catalysis.

PubMed

Cuthbertson, James D; MacMillan, David W C

2015-03-05

The direct functionalization of unactivated sp(3) C-H bonds is still one of the most challenging problems facing synthetic organic chemists. The appeal of such transformations derives from their capacity to facilitate the construction of complex organic molecules via the coupling of simple and otherwise inert building blocks, without introducing extraneous functional groups. Despite notable recent efforts, the establishment of general and mild strategies for the engagement of sp(3) C-H bonds in C-C bond forming reactions has proved difficult. Within this context, the discovery of chemical transformations that are able to directly functionalize allylic methyl, methylene and methine carbons in a catalytic manner is a priority. Although protocols for direct oxidation and amination of allylic C-H bonds (that is, C-H bonds where an adjacent carbon is involved in a C = C bond) have become widely established, the engagement of allylic substrates in C-C bond forming reactions has thus far required the use of pre-functionalized coupling partners. In particular, the direct arylation of non-functionalized allylic systems would enable access to a series of known pharmacophores (molecular features responsible for a drug's action), though a general solution to this long-standing challenge remains elusive. Here we report the use of both photoredox and organic catalysis to accomplish a mild, broadly effective direct allylic C-H arylation. This C-C bond forming reaction readily accommodates a broad range of alkene and electron-deficient arene reactants, and has been used in the direct arylation of benzylic C-H bonds.

77 FR 4997 - Proposed Information Collection; Comment Request; Alaska Individual Fishing Quota Cost Recovery...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

... requires Registered Buyers to submit information about the value and volume of landings of IFQ species. II... of automated collection techniques or other forms of information technology. Comments submitted in... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Proposed Information...

78 FR 63183 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request; Mobile...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-23

... of air conditioning systems and recovery/recycling equipment. Form Numbers: None. Respondents... automotive repair shops, automotive repair shops not elsewhere classified, including air conditioning and... Request Submitted to OMB for Review and Approval; Comment Request; Mobile Air Conditioner Retrofitting...

78 FR 7779 - Information Collection Requirement Submitted to the Office of Management and Budget (OMB) for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... FEDERAL COMMUNICATIONS COMMISSION Information Collection Requirement Submitted to the Office of Management and Budget (OMB) for Emergency Review and Approval AGENCY: Federal Communications Commission... forms of information technology; and ways to further reduce the information collection burden on small...

Theoretical verification and extension of the McKean relationship between bond lengths and stretching frequencies

NASA Astrophysics Data System (ADS)

Larsson, J. A.; Cremer, D.

1999-08-01

Vibrational spectra contain explicit information on the electronic structure and the bonding situation of a molecule, which can be obtained by transforming the vibrational normal modes of a molecule into appropriate internal coordinate modes, which are localized in a fragment of the molecule and which are associated to that internal coordinate that describes the molecular fragment in question. It is shown that the adiabatic internal modes derived recently (Int. J. Quant. Chem., 67 (1998) 1) are the theoretical counterparts of McKean's isolated CH stretching modes (Chem. Soc. Rev., 7 (1978) 399). Adiabatic CH stretching frequencies obtained from experimental vibrational spectra can be used to determine CH bond lengths with high accuracy. Contrary to the concept of isolated stretching frequencies a generalization to any bond of a molecule is possible as is demonstrated for the CC stretching frequencies. While normal mode frequencies do not provide a basis to determine CC bond lengths and CC bond strengths, this is possible with the help of the adiabatic CC stretching frequencies. Measured vibrational spectra are used to describe different types of CC bonds in a quantitative way. For CH bonds, it is also shown that adiabatic stretching frequency leads to the definition of an ideal dissociation energy, which contrary to the experimentally determined dissociation energy is a direct measure of the bond strength. The difference between measured and ideal dissociation energies gives information on stabilization or destabilization of the radicals formed in a dissociation process.

Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer

PubMed Central

Rondinelli, Beatrice; Rosano, Dalia; Antonini, Elena; Frenquelli, Michela; Montanini, Laura; Huang, DaChuan; Segalla, Simona; Yoshihara, Kosuke; Amin, Samir B.; Lazarevic, Dejan; The, Bin Tean; Verhaak, Roel G.W.; Futreal, P. Andrew; Di Croce, Luciano; Chin, Lynda; Cittaro, Davide; Tonon, Giovanni

2015-01-01

Mutations in genes encoding chromatin-remodeling proteins are often identified in a variety of cancers. For example, the histone demethylase JARID1C is frequently inactivated in patients with clear cell renal cell carcinoma (ccRCC); however, it is largely unknown how JARID1C dysfunction promotes cancer. Here, we determined that JARID1C binds broadly to chromatin domains characterized by the trimethylation of lysine 9 (H3K9me3), which is a histone mark enriched in heterochromatin. Moreover, we found that JARID1C localizes on heterochromatin, is required for heterochromatin replication, and forms a complex with established players of heterochromatin assembly, including SUV39H1 and HP1α, as well as with proteins not previously associated with heterochromatin assembly, such as the cullin 4 (CUL4) complex adaptor protein DDB1. Transcription on heterochromatin is tightly suppressed to safeguard the genome, and in ccRCC cells, JARID1C inactivation led to the unrestrained expression of heterochromatic noncoding RNAs (ncRNAs) that in turn triggered genomic instability. Moreover, ccRCC patients harboring JARID1C mutations exhibited aberrant ncRNA expression and increased genomic rearrangements compared with ccRCC patients with tumors endowed with other genetic lesions. Together, these data suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs. Moreover, our results shed light on a mechanism that underlies genomic instability in sporadic cancers. PMID:26551685

Mechanistic Explanation of the pH Dependence and Onset Potentials for Hydrocarbon Products from Electrochemical Reduction of CO on Cu (111)

DOE PAGES

Xiao, Hai; Cheng, Tao; Goddard, William A.; ...

2015-12-30

Energy and environmental concerns demand development of more efficient and selective electrodes for electrochemical reduction of CO 2 to form fuels and chemicals. Since Cu is the only pure metal exhibiting reduction to form hydrocarbon chemicals, we focus here on the Cu (111) electrode. We present a methodology for density functional theory calculations to obtain accurate onset electrochemical potentials with explicit constant electrochemical potential and pH effects using implicit solvation. We predict the atomistic mechanisms underlying electrochemical reduction of CO, finding that (1) at acidic pH, the C 1 pathway proceeds through COH to CHOH to form CH 4 whilemore » C 2 (C 3) pathways are kinetically blocked; (2) at neutral pH, the C 1 and C 2 (C 3) pathways share the COH common intermediate, where the branch to C-C coupling is realized by a novel CO-COH pathway; and (3) at high pH, early C-C coupling through adsorbed CO dimerization dominates, suppressing the C 1 pathways by kinetics, thereby boosting selectivity for multi-carbon products.« less

78 FR 46330 - Public ICWG Announcement-2013

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-31

... Resolution Matrix (CRM) form. These forms along with the Was/Is Matrix, current versions of the documents... Compatibility (ABC) Study Group Kickoff Please provide them in the CRM form and submit to the SMC/GPER mailbox...

Cytotoxic active constituents of essential oils of Curcuma longa and Curcuma zanthorrhiza.

PubMed

Schmidt, Erich; Ryabchenko, Boris; Wanner, Juergen; Jäger, Walter; Jirovetz, Leopold

2015-01-01

The polar and apolar fractions of Curcuma longa and C. zanthorriza enriched by ar-turmerone, ar-curcumene and xanthorrizol were screened for cytotoxic activity against the HeLa cell line. Actinomycin D and curcumin were used as reference samples, both known for their cytotoxic properties. Amongst all fractions tested, the xanthorrizol fraction (CC50: 26.1 ± 1.9 μM) showed the strongest cytotoxic properties similar to those of curcumin (CC50: 8.1 ± 1.7 μM). Further studies also revealed that the cytotoxic effects of the extracts and pure compounds are caused by apoptosis induction identified by the cleaved form of PARP protein.

77 FR 67435 - Agency Information Collection Activities: Proposed Request and Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-09

... rehabilitation (VR) agencies submit Form SSA-199 to SSA to obtain reimbursement of costs incurred for providing VR services. SSA requires state VR agencies to submit reimbursement claims for the following categories: (1) Claiming reimbursement for VR services provided; (2) certifying adherence to cost containment...

30 CFR 1210.55 - May I submit this royalty report manually?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false May I submit this royalty report manually? 1210.55 Section 1210.55 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR Natural Resources Revenue FORMS AND REPORTS Royalty Reports-Oil, Gas, and Geothermal...

30 CFR 1210.52 - What royalty reports must I submit?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false What royalty reports must I submit? 1210.52 Section 1210.52 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR Natural Resources Revenue FORMS AND REPORTS Royalty Reports-Oil, Gas, and Geothermal Resources...

30 CFR 1210.54 - Must I submit this royalty report electronically?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Must I submit this royalty report electronically? 1210.54 Section 1210.54 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR Natural Resources Revenue FORMS AND REPORTS Royalty Reports-Oil, Gas, and...

30 CFR 1210.51 - Who must submit royalty reports?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Who must submit royalty reports? 1210.51 Section 1210.51 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR Natural Resources Revenue FORMS AND REPORTS Royalty Reports-Oil, Gas, and Geothermal Resources...

75 FR 69921 - Trademark Manual of Examining Procedure, Seventh Edition

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2010-11-16

... suggestions for improving the form and content of the TMEP be submitted via electronic mail message to [email protected] . Written comments may also be submitted by mail addressed to: Commissioner for Trademarks, P... Commissioner for Trademark Examination Policy, by electronic mail at: [email protected] ; or by mail...

78 FR 27243 - Proposed Collection; 60-Day Comment Request: Interactive Informed Consent for Pediatric Clinical...

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2013-05-09

... public comment on proposed data collection projects, the National Institute Heart, Lung, and Blood... projects to be submitted to the Office of Management and Budget (OMB) for review and approval. Written... other technological collection techniques or other forms of information technology. To Submit Comments...

75 FR 54000 - Reports, Forms, and Record keeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-02

... information from the public, it must receive approval from the Office of Management and Budget (OMB). Under... submitted to Docket Management, Room W12-140, ground level, 1200 New Jersey Ave., SE., Washington, DC 20590... instructions for submitting comments. Mail: Docket Management Facility; U.S. Department of Transportation, 1200...

75 FR 33618 - Notice of Public Information Collection(s) Being Submitted for Review and Approval to the Office...

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2010-06-14

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2010-08-24

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2010-04-29

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2010-04-22

... FEDERAL COMMUNICATIONS COMMISSION Notice of Public Information Collection(s) Being Submitted for... forms of information technology; and (e) ways to further reduce the information collection burden for.... SUMMARY: The Federal Communications Commission, as part of its continuing effort to reduce paperwork...

75 FR 45113 - Notice of Public Information Collection(s) Being Submitted for Review and Approval to the Office...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... FEDERAL COMMUNICATIONS COMMISSION Notice of Public Information Collection(s) Being Submitted for... forms of information technology; and (e) ways to further reduce the information collection burden for.... SUMMARY: The Federal Communications Commission, as part of its continuing effort to reduce paperwork...

77 FR 51026 - Federal Acquisition Regulation; Submission for OMB Review; Government Property

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-23

... appropriate technological collection techniques or other forms of information technology. DATES: Submit....606-1 requires a contractor to submit inventory schedules. (b) FAR 45.606-3(a) requires a contractor to correct and resubmit inventory schedules as necessary. (c) FAR 52.245-1(f)(1)(ii) requires...

75 FR 17410 - Federal Acquisition Regulation; Information Collection; Government Property

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-06

... contractors to submit inventory disposal schedules to the Plant Clearance Officer. (l) FAR 52.245-9(d... of appropriate technological collection techniques or other forms of information technology. DATES... following requirements: (a) FAR 45.606-1 requires a contractor to submit inventory schedules. (b) FAR 45.606...

47 CFR 1.1113 - Filing locations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... by the ULS electronic filing system on FCC Form 159) and submit such number with the payment in order... received more than ten (10) days after electronic filing of an application on a Bureau/Office electronic... Television Relay Service (CARS) that are submitted electronically via the Cable Operations and Licensing...

78 FR 12752 - Information Collection Being Submitted for Review and Approval to the Office of Management and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... FEDERAL COMMUNICATIONS COMMISSION Information Collection Being Submitted for Review and Approval to the Office of Management and Budget AGENCY: Federal Communications Commission. ACTION: Notice and... respondents, including the use of automated collection techniques or other forms of information technology...

75 FR 62817 - Notice of Public Information Collection(s) Being Submitted to OMB for Review and Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-13

... FEDERAL COMMUNICATIONS COMMISSION Notice of Public Information Collection(s) Being Submitted to OMB for Review and Approval September 30, 2010. SUMMARY: The Federal Communications Commission, as... automated collection techniques or other forms of information technology. DATES: Written comments should be...

75 FR 22125 - Trans-Union Interstate Pipeline, L.P.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-27

... Interstate Pipeline, L.P.; Notice of Filing April 20, 2010. Take notice that on April 9, 2010 Trans-Union Interstate Pipeline, L.P. submitted a request for waiver of the requirement to submit the 2009 FERC Form No... am] BILLING CODE 6717-01-P ...

76 FR 12976 - Agency Information Collection Activities: Proposed Collection: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... the statewide needs assessment and initial State plans for developing the program in order to meet the criteria identified in the legislation. Submission of the needs assessments in the form and manner required... submitted needs assessments that identified communities at risk. The needs assessments submitted were...

49 CFR 579.29 - Manner of reporting.

Code of Federal Regulations, 2013 CFR

2013-10-01

... identified on NHTSA's Internet homepage (www.nhtsa.dot.gov). A manufacturer must use templates provided at... templates. (2) Each report required under § 579.27 of this part may be submitted to NHTSA's early warning... through 579.26 of this part may be submitted in digital form using a graphic compression protocol...

49 CFR 579.29 - Manner of reporting.

Code of Federal Regulations, 2011 CFR

2011-10-01

... identified on NHTSA's Internet homepage (www.nhtsa.dot.gov). A manufacturer must use templates provided at... templates. (2) Each report required under § 579.27 of this part may be submitted to NHTSA's early warning... through 579.26 of this part may be submitted in digital form using a graphic compression protocol...

49 CFR 579.29 - Manner of reporting.

Code of Federal Regulations, 2012 CFR

2012-10-01

... identified on NHTSA's Internet homepage (www.nhtsa.dot.gov). A manufacturer must use templates provided at... templates. (2) Each report required under § 579.27 of this part may be submitted to NHTSA's early warning... through 579.26 of this part may be submitted in digital form using a graphic compression protocol...

49 CFR 579.29 - Manner of reporting.

Code of Federal Regulations, 2014 CFR

2014-10-01

... identified on NHTSA's Internet homepage (www.nhtsa.dot.gov). A manufacturer must use templates provided at... templates. (2) Each report required under § 579.27 of this part may be submitted to NHTSA's early warning... through 579.26 of this part may be submitted in digital form using a graphic compression protocol...

49 CFR 512.12 - What if I am submitting multiple items of information?

Code of Federal Regulations, 2014 CFR

2014-10-01

... information. However, general or nonspecific assertions or analysis may be insufficient to form an adequate... information? 512.12 Section 512.12 Transportation Other Regulations Relating to Transportation (Continued... INFORMATION Additional Requirements § 512.12 What if I am submitting multiple items of information? Any...

49 CFR 512.12 - What if I am submitting multiple items of information?

Code of Federal Regulations, 2012 CFR

2012-10-01

... information. However, general or nonspecific assertions or analysis may be insufficient to form an adequate... information? 512.12 Section 512.12 Transportation Other Regulations Relating to Transportation (Continued... INFORMATION Additional Requirements § 512.12 What if I am submitting multiple items of information? Any...

49 CFR 512.12 - What if I am submitting multiple items of information?

Code of Federal Regulations, 2010 CFR

2010-10-01

... information. However, general or nonspecific assertions or analysis may be insufficient to form an adequate... information? 512.12 Section 512.12 Transportation Other Regulations Relating to Transportation (Continued... INFORMATION Additional Requirements § 512.12 What if I am submitting multiple items of information? Any...

Factors that affect implementation of web-based faculty evaluation forms: residents' perspectives from a developing country.

PubMed

Ibrahim, S H; Ali, S K; Sadaf, S

2010-08-01

A web-based evaluation system for residents to provide feedback on faculty was piloted in four training programs at the Aga Khan University prior to institution-wide implementation. Of the four programs, less than 50% of forms were submitted by residents of three programs while more than 70% of forms were submitted by the residents of one program. This study was conducted to identify reasons for the varying participation rates of the four programs with a view to improving the system. A qualitative approach was employed using focus group discussions (FGDs). Volunteers were invited and three groups of eight to ten residents each were formed. Participants for FGDs were selected from all residency years. FGDs were used to identify residents' perceptions regarding the web-based faculty evaluation system and to identify residents' problems and concerns with completing the web-based faculty evaluating forms. Technical issues in completing and submitting the forms online were identified to be the main deterrents to completing the evaluation forms. Non-accessibility of a resource person for resolving technical problems with the software and the burden of taking time out to complete the forms were considered as limiting factors by many residents. Residents recommended a focused orientation session to the new system within the departments. Residents' confidence and support are key to promoting adequate participation in web-based evaluations. Focused orientation sessions, reinforcement, reminders, assurances of confidentiality, and removal of technical glitches should help to improve resident participation.

Analyzed Boise Data for Oscillatory Hydraulic Tomography

DOE Data Explorer

Lim, David

2015-07-01

Data here has been "pre-processed" and "analyzed" from the raw data submitted to the GDR previously (raw data files found at http://gdr.openei.org/submissions/479. doi:10.15121/1176944 after 30 September 2017). First, we submit .mat files which are the "pre-processed" data (must have MATLAB software to use). Secondly, the csv files contain submitted data in its final analyzed form before being used for inversion. Specifically, we have fourier coefficients obtained from Fast Fourier Transform Algorithms.

78 FR 66704 - Information Collections Being Reviewed by the Federal Communications Commission

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-06

... Displacement Application. Form Number: FCC Form 346. Type of Review: Extension of a currently approved... station with facilities on out-of-core channels (channels 52-59) submit a digital displacement (FCC Form...

5 CFR 950.204 - Local eligibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... electronic technology that allows removal of the need for geographic restrictions on giving as determined by... revenue of less than $100,000 reported on its IRS Form 990 or pro form IRS Form 990 submitted to the CFC...

49 CFR 191.19 - Report forms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... forms. Copies of the prescribed report forms are available without charge upon request from the address... 49 Transportation 3 2010-10-01 2010-10-01 false Report forms. 191.19 Section 191.19 Transportation... size and kind of paper. In addition, the information required by these forms may be submitted by any...

76 FR 35913 - Agency Information Collection Activities: Proposed Collection; Comments Requested: U.S. Official...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-20

... II Controlled Substances (Accountable Forms); Order Form Requisition; DEA Form 222, 222a, Controlled... Justice (DOJ), Drug Enforcement Administration (DEA) will be submitting the following information... applicable component of the Department sponsoring the collection: Form number: DEA Forms 222 and 222a...

Benchmark studies on the building blocks of DNA. 3. Watson-Crick and stacked base pairs.

PubMed

Szalay, Péter G; Watson, Thomas; Perera, Ajith; Lotrich, Victor; Bartlett, Rodney J

2013-04-18

Excited states of stacked adenine-thymine and guanine-cytosine pairs as well as the Watson-Crick pair of guanine-thymine have been investigated using the equation of motion coupled-cluster (EOM-CC) method with single and double as well as approximate triple excitations. Transitions have been assigned, and the form of the excitations has been analyzed. The majority of the excitations could be classified as localized on the nucleobases, but for all three studied systems, charge-transfer (CT) transitions could also be identified. The main aim of this study was to compare the performance of lower-level methods (ADC(2) and TDDFT) to the high-level EOM-CC ones. It was shown that both ADC(2) and TDDFT with long-range correction have nonsystematic error in excitation energies, causing alternation of the energetic ordering of the excitations. Considering the high costs of the EOM-CC calculations, there is a need for reliable new approximate methods.

Implementation of the FDTD method in cylindrical coordinates for dispersive materials: Modal study of C-shaped nano-waveguides

NASA Astrophysics Data System (ADS)

kebci, Zahia; Belkhir, Abderrahmane; Mezeghrane, Abdelaziz; Lamrous, Omar; Baida, Fadi Issam

2018-03-01

The objective of this work is to develop a code based on the finite difference time domain method in cylindrical coordinates (CC-FDTD) that integrates the Drude Critical Points model (DCP) and to apply it in the study of a metallic C-shaped waveguide (CSWG). The integrated dispersion model allows an accurate description of noble metals in the optical range and working in cylindrical coordinates is necessary to bypass the staircase effect induced by a Cartesian mesh especially in the case of curved geometrical forms. The CC-FDTD code developed as a part of this work is more general than the Body-Of-Revolution-FDTD algorithm that can only handle structures exhibiting a complete cylindrical symmetry. A N-order CC-FDTD code is then derived and used to perform a parametric study of an infinitly-long CSWG for nano-optic applications. Propagation losses and dispersion diagrams are given for different geometrical parameters.

Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1.

PubMed

Millard, Christopher J; Ludeman, Justin P; Canals, Meritxell; Bridgford, Jessica L; Hinds, Mark G; Clayton, Daniel J; Christopoulos, Arthur; Payne, Richard J; Stone, Martin J

2014-11-04

Trafficking of leukocytes in immune surveillance and inflammatory responses is activated by chemokines engaging their receptors. Sulfation of tyrosine residues in peptides derived from the eosinophil chemokine receptor CCR3 dramatically enhances binding to cognate chemokines. We report the structural basis of this recognition and affinity enhancement. We describe the structure of a CC chemokine (CCL11/eotaxin-1) bound to a fragment of a chemokine receptor: residues 8–23 of CCR3, including two sulfotyrosine residues. We also show that intact CCR3 is sulfated and sulfation enhances receptor activity. The CCR3 sulfotyrosine residues form hydrophobic, salt bridge and cation-p interactions with residues that are highly conserved in CC chemokines. However, the orientation of the chemokine relative to the receptor N terminus differs substantially from those observed for two CXC chemokines, suggesting that initial binding of the receptor sulfotyrosine residues guides subsequent steps in receptor activation, thereby influencing the receptor conformational changes and signaling.

Hydrogen production from algal biomass via steam gasification.

PubMed

Duman, Gozde; Uddin, Md Azhar; Yanik, Jale

2014-08-01

Algal biomasses were tested as feedstock for steam gasification in a dual-bed microreactor in a two-stage process. Gasification experiments were carried out in absence and presence of catalyst. The catalysts used were 10% Fe₂O₃-90% CeO₂ and red mud (activated and natural forms). Effects of catalysts on tar formation and gasification efficiencies were comparatively investigated. It was observed that the characteristic of algae gasification was dependent on its components and the catalysts used. The main role of the catalyst was reforming of the tar derived from algae pyrolysis, besides enhancing water gas shift reaction. The tar reduction levels were in the range of 80-100% for seaweeds and of 53-70% for microalgae. Fe₂O₃-CeO₂ was found to be the most effective catalyst. The maximum hydrogen yields obtained were 1036 cc/g algae for Fucus serratus, 937 cc/g algae for Laminaria digitata and 413 cc/g algae for Nannochloropsis oculata. Copyright © 2014 Elsevier Ltd. All rights reserved.

A combined crossed molecular beam and theoretical investigation of the reaction of the meta-tolyl radical with vinylacetylene--toward the formation of methylnaphthalenes.

PubMed

Yang, Tao; Muzangwa, Lloyd; Kaiser, Ralf I; Jamal, Adeel; Morokuma, Keiji

2015-09-07

Crossed molecular beam experiments and electronic structure calculations on the reaction of the meta-tolyl radical with vinylacetylene were conducted to probe the formation of methyl-substituted naphthalene isomers. We present the compelling evidence that under single collision conditions 1- and 2-methylnaphthalene can be formed without an entrance barrier via indirect scattering dynamics through a bimolecular collision of two non-PAH reactants: the meta-tolyl radical and vinylacetylene. The electronic structure calculations, conducted at the UCCSD(T)-F12b/cc-pVDZ//UM06-2x/cc-pVTZ + ZPE(UM06-2x/cc-pVTZ) level of theory, reveal that this reaction is initiated by the barrierless addition of the meta-tolyl radical to the terminal vinyl carbon (C1) of vinylacetylene, via a van-der-Waals complex implying that this mechanism can play a key role in forming methyl-substituted PAHs in low temperature extreme environments such as the low temperature interstellar medium and hydrocarbon-rich atmospheres of planets and their moons in the outer solar system. The reaction mechanism, proposed from the C11H11 potential energy surface, involves a sequence of isomerizations involving hydrogen transfer and ring closure, followed by hydrogen dissociation, which eventually leads to 1- and 2-methylnaphthalene in an overall exoergic process.

48 CFR 53.108 - Recommendations concerning forms.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Recommendations concerning... (CONTINUED) CLAUSES AND FORMS FORMS General 53.108 Recommendations concerning forms. Users of this regulation... referenced in this regulation. Recommendations from within an executive agency shall be submitted to the...

2002 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

DOE Office of Scientific and Technical Information (OSTI.GOV)

M. Stockton

2003-11-01

For reporting year 2002, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds and mercury as required under the Emergency Planning and Community Right-to-Know Act (EPCRA), Section 313. No other EPCRA Section 313 chemicals were used in 2002 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical usage and threshold determinations for LANL for calendar year 2002 as well as provide background information about the data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxicmore » Chemical Release Inventory report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999 EPA promulgated a final rule on Persistent Bioaccumulative Toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable under EPCRA Section 313. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.« less

2006 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ecology and Air Quality Group

2007-12-12

For reporting year 2006, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead as required under the Emergency Planning and Community Right-to-Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2006 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2006, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventorymore » Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.« less

2008 Toxic Chemical Release Inventory 2008 Toxic Chemical Release Inventory Community Right-to-Know Act of 1986, Title III, Section 313

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ecology and Air Quality Group

2009-10-01

For reporting year 2008, Los Alamos National Laboratory (LANL) submitted a Form R report for lead as required under the Emergency Planning and Community Right-to- Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2008 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2008, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory Reportmore » (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.« less

Creating Catalytic Collaborations between Theater Artists, Scientists, and Research Institutions

NASA Astrophysics Data System (ADS)

Wise, Debra

2012-02-01

Catalyst Collaborative@MIT (CC@MIT) is a collaboration between MIT and Underground Railway Theater (URT), a company with 30 years experience creating theater through interdisciplinary inquiry and engaging community. CC@MIT is dedicated to creating and presenting plays that deepen public understanding about science, while simultaneously providing artistic and emotional experiences not available in other forms of dialogue about science. CC@MIT engages audiences in thinking about themes in science of social and ethical concern; provides insight into the culture of science and the impact of that culture on society; and examines the human condition through the lens of science that intersects our lives and the lives of scientists. Original productions range from Einstein's Dreams to From Orchids to Octopi -- an evolutionary love story; classics re-framed include The Life of Galileo and Breaking the Code (about Alan Turing). CC@MIT commissions playwrights and scientists to create plays; engages audiences with scientists; performs at MIT and a professional venue near the campus; collaborates with the Cambridge Science Festival and MIT Museum; engages MIT students, as well as youth and children. Artistic Director Debra Wise will address how the collaboration developed, what opportunities are provided by collaborations between theaters and scientific research institutions, and lessons learned of value to the field.

Small cell carcinoma with concomitant adenocarcinoma arising in a Barrett's oesophagus: report of a case with a favourable behaviour.

PubMed

Bibeau, Frédéric; Chateau, Marie-Christine; Guiu, Michel; Assenat, Eric; Azria, David; Lavaill, Rosy; Ychou, Marc; Boissière-Michot, Florence

2008-01-01

Most Barrett's oesophagus-associated cancers are adenocarcinomas which occur in a pure form. They are rarely combined with another type of malignancy, such as endocrine tumours. Within the endocrine spectrum, small cell carcinomas (SmCC) usually have a highly aggressive behaviour with a poor prognosis. We report a case of composite SmCC and adenocarcinoma in the setting of a Barrett's oesophagus, in a 54-year-old man. This tumour was identified on a surgical specimen after neoadjuvant treatment with radiotherapy and 5-FU-Cis-platin based chemotherapy. The SmCC component was positive for chromogranin A, synaptophysin, neural cell adhesion molecule and neuron-specific enolase and negative for high molecular weight cytokeratin. The adenocarcinoma component showed a converse phenotype. In our case, the origin of the SmCC component could be explained by the numerous chromogranin A-positive cells observed in the Barrett's oesophagus or by the potential progenitor cells that may be located in the submucosal oesophageal gland ducts and the Barrett's metaplasia. Our report is thus indicative of the high and totipotential risk of Barrett's oesophagus. Moreover, it is particular because of its favourable behaviour, with a 6-year disease-free survival, after neoadjuvant chemoradiation, surgery and postoperative chemotherapy.

Best practice in the management of clinical coding services: Insights from a project in the Republic of Ireland, Part 2.

PubMed

Reid, Beth A; Ridoutt, Lee; O'Connor, Paul; Murphy, Deirdre

2017-09-01

This is the second of two articles about best practice in the management of coding services. The best practice project was part of a year-long project conducted in the Republic of Ireland to review the quality of the Hospital Inpatient Enquiry data for its use in activity-based funding. The four methods used to address the best practice aspect of the project were described in detail in Part 1. The results included in this article are those relating to the coding manager's background, preparation and style, clinical coder (CC) workforce adequacy, the CC workforce structure and career pathway, and the physical and psychological work environment for the clinical coding service. Examples of best practice were found in the study hospitals but there were also areas for improvement. Coding managers would benefit from greater support in the form of increased opportunities for management training and a better method for calculating CC workforce numbers. A career pathway is needed for CCs to progress from entry to expert CC, mentor, manager and quality controller. Most hospitals could benefit from investment in infrastructure that places CCs in a physical environment that tells them they are an important part of the hospital and their work is valued.

Subunit III-depleted cytochrome c oxidase provides insight into the process of proton uptake by proteins

PubMed Central

Varanasi, Lakshman; Hosler, Jonathan P.

2011-01-01

We review studies of subunit III-depleted cytochrome c oxidase (CcO III (−)) that elucidate the structural basis of steady-state proton uptake from solvent into an internal proton transfer pathway. The removal of subunit III from R. sphaeroides CcO makes proton uptake into the D pathway a rate-determining step, such that measurements of the pH dependence of steady-state O2 consumption can be used to compare the rate and functional pKa of proton uptake by D pathways containing different initial proton acceptors. The removal of subunit III also promotes spontaneous suicide inactivation by CcO, greatly shortening its catalytic lifespan. Because the probability of suicide inactivation is controlled by the rate at which the D pathway delivers protons to the active site, measurements of catalytic lifespan provide a second method to compare the relative efficacy of proton uptake by engineered CcO III (−) forms. These simple experimental systems have been used to explore general questions of proton uptake by proteins, such as the functional value of an initial proton acceptor, whether an initial acceptor must be surface-exposed, which side chains will function as initial proton acceptors and whether multiple acceptors can speed proton uptake. PMID:22023935

2004 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

DOE Office of Scientific and Technical Information (OSTI.GOV)

M. Stockton

2006-01-15

Section 313 of Emergency Planning and Community Right-to-Know Act (EPCRA) specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. For reporting year 2004, Losmore » Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds, nitric acid, and nitrate compounds as required under the EPCRA Section 313. No other EPCRA Section 313 chemicals were used in 2004 above the reportable thresholds. This document provides a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2004, as well as background information about data included on the Form R reports.« less

78 FR 7802 - Agency Information Collection Activities: Application for Allowance in Duties

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... should be received on or before March 6, 2013. ADDRESSES: Interested persons are invited to submit... of 1930. This form is accessible at: http://forms.cbp.gov/pdf/CBP_Form_4315.pdf . Action: CBP...

42 CFR 37.60 - Submitting required chest roentgenograms and miner identification documents.

Code of Federal Regulations, 2012 CFR

2012-10-01

... prescribed in this subpart, all the forms shall be submitted with his or her name and social security account... miner identification document containing the miner's name, address, social security number and place of... format specified by NIOSH either using portable electronic media, or a secure electronic file transfer...

77 FR 50204 - Agency Information Collection Activities: Proposed Request and Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-20

...(c)(1)&(2), 416.2201(a)&(b), 416.2221(a), 34 CFR 361--0960- 0310. State Vocational Rehabilitation (VR) agencies submit Form SSA-199 to SSA to obtain reimbursement of costs incurred for providing VR services. SSA requires state VR agencies to submit reimbursement claims for the following categories: (1...

76 FR 54986 - NRC Enforcement Policy

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

.... You may submit comments by any one of the following methods: Federal Rulemaking Web site: Go to http... submitted in writing or in electronic form will be posted on the NRC Web site and on the Federal rulemaking Web site, http://www.regulations.gov . Because your comments will not be edited to remove any...

30 CFR 1206.458 - Determination of washing allowances.

Code of Federal Regulations, 2011 CFR

2011-07-01

... contract. However, before any deduction may be taken, the lessee must submit a completed page one of Form...-arm's-length or no contract situations. However, before any estimated or actual deduction may be taken... allowances specified in paragraphs (c)(1)(v) and (c)(1)(vi) of this section, the lessee shall submit page one...

78 FR 25321 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

... Board (RRB) conducts a number of customer surveys designed to determine the kinds and quality of... what extent services can be improved. The surveys are limited to data collections that solicit strictly.... This generic authority allows the RRB to submit a variety of new or revised customer survey instruments...

30 CFR 210.55 - May I submit this royalty report manually?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false May I submit this royalty report manually? 210.55 Section 210.55 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT FORMS AND REPORTS Royalty Reports-Oil, Gas, and Geothermal Resources § 210.55 May I...

30 CFR 210.52 - What royalty reports must I submit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What royalty reports must I submit? 210.52 Section 210.52 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT FORMS AND REPORTS Royalty Reports-Oil, Gas, and Geothermal Resources § 210.52 What royalty reports...

78 FR 3394 - Agency Information Collection Activities: Proposed Collection; Comment Request-Performance...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

... other forms of information technology. Comments may be sent to: Billy DeLancey, Food and Nutrition...://www.regulations.gov and follow the online instructions for submitting comments electronically. All... submit one review schedule every one, two or three years, depending on the project area make-up of the...

75 FR 23762 - Notice of Public Information Collection Being Submitted for Review and Approval to the Office of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

... FEDERAL COMMUNICATIONS COMMISSION Notice of Public Information Collection Being Submitted for... forms of information technology; and (e) ways to further reduce the information collection burden for... offers to pay; and (10) any additional information required by applicable state or local laws. 47 CFR 76...

76 FR 7562 - Notice of Public Information Collection(s) Being Submitted for Review to the Office of Management...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... FEDERAL COMMUNICATIONS COMMISSION Notice of Public Information Collection(s) Being Submitted for..., including the use of automated collection techniques or other forms of information technology; (e) ways to... authority for this information collection is contained in the Communications Act of 1934, as amended...

76 FR 47584 - Information Collection Being Submitted to the Office of Management and Budget (OMB) for Emergency...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

... information collection requirements is found at Section 225 of the Communications Act, 47 U.S.C. 225. The law... FEDERAL COMMUNICATIONS COMMISSION Information Collection Being Submitted to the Office of... forms of information technology; and ways to further reduce the information collection burden on small...

75 FR 36388 - Notice of Public Information Collection(s) Being Submitted for Review and Approval to the Office...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

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76 FR 66066 - Information Collection(s) Being Submitted for Review to the Office of Management and Budget for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-25

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76 FR 76728 - Benefits and Burdens of Requiring Commenters To File Cited Materials in Rulemaking Proceedings as...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-08

... parties have not submitted in the record, including materials such as state statutes, academic articles..., comments submitted in other Commission rulemaking proceedings, public financial filings, academic....g., daily newsletters), the material is very bulky, or the material is in the form of a database...

76 FR 65521 - Information Collection; Geological and Geophysical Explorations of the Outer Continental Shelf...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-21

... submitted. Permittees are to be reimbursed also for the reasonable cost of processing geophysical information required to be submitted when processing is in a form or manner required by the Director, BOEM... G&G exploration, including deep stratigraphic tests/ revisions when necessary. 74 applications x $2...

76 FR 29695 - Approval, and Promulgation of Air Quality Implementation Plans; Indiana; Redesignation of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-23

... directly or formed secondarily through chemical reactions in the atmosphere. Sulfates are a type of..., Indiana submitted modeling intended to show that the Evansville area would attain and maintain the... particular, on December 7, 2009, Indiana submitted the results of modeling purporting to show PM 2.5...

77 FR 5858 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... Regulatory Affairs (OIRA), Office of Management and Budget (OMB). Our ICR describes the information we seek... requiring an applicant to submit documentary evidence of marriage are prescribed in 20 CFR 219.30. In the absence of documentary evidence, the RRB needs to determine if a valid marriage existed between a spouse...

78 FR 18633 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... Affairs (OIRA), Office of Management and Budget (OMB). Our ICR describes the information we seek to... requiring an applicant to submit documentary evidence of marriage are prescribed in 20 CFR 219.30. In the absence of documentary evidence, the RRB needs to determine if a valid marriage existed between a spouse...

76 FR 81554 - Notice of Information Collection Under Emergency Review: 60-Day Notice of Proposed Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

... methods: Email: [email protected] . You must include the DS form number, information collection... review of this information collection is also being undertaken. The submitting agency requests written... Federal Register. You may submit comments by any of the following methods: Email: [email protected] . Mail...

10 CFR 40.36 - Financial assurance and recordkeeping for decommissioning.

Code of Federal Regulations, 2014 CFR

2014-01-01

... funding plan as described in paragraph (d) of this section. (b) Each applicant for a specific license... 100 mCi in a readily dispersible form shall either— (1) Submit a decommissioning funding plan as... this section shall submit a decommissioning funding plan as described in paragraph (d) of this section...

10 CFR 40.36 - Financial assurance and recordkeeping for decommissioning.

Code of Federal Regulations, 2011 CFR

2011-01-01

... funding plan as described in paragraph (d) of this section. (b) Each applicant for a specific license... 100 mCi in a readily dispersible form shall either— (1) Submit a decommissioning funding plan as... this section shall submit a decommissioning funding plan as described in paragraph (d) of this section...

10 CFR 40.36 - Financial assurance and recordkeeping for decommissioning.

Code of Federal Regulations, 2013 CFR

2013-01-01

... funding plan as described in paragraph (d) of this section. (b) Each applicant for a specific license... 100 mCi in a readily dispersible form shall either— (1) Submit a decommissioning funding plan as... this section shall submit a decommissioning funding plan as described in paragraph (d) of this section...

10 CFR 40.36 - Financial assurance and recordkeeping for decommissioning.

Code of Federal Regulations, 2012 CFR

2012-01-01

... readily dispersible form shall submit a decommissioning funding plan as described in paragraph (d) of this...— (1) Submit a decommissioning funding plan as described in paragraph (d) of this section; or (2... funding plan as described in paragraph (d) of this section or a certification of financial assurance for...

A Lunar Chronology

ERIC Educational Resources Information Center

Schaeffer, Oliver A.

1973-01-01

Discusses methods used in determination of absolute isotopic ages for the returned lunar material, including the uranium-lead, rubidium-strontium, and argon 40-argon 39 ratio methods. Indicates that there would exist a basin-forming bombardment period for the Moon extending over at least 300 million years. (CC)

78 FR 2647 - Dental Devices; Reclassification of Blade-Form Endosseous Dental Implant

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-14

.... FDA-2012-N-0677] Dental Devices; Reclassification of Blade-Form Endosseous Dental Implant AGENCY: Food...) is proposing to reclassify the blade- form endosseous dental implant, a preamendments class III... proposing to revise the classification of blade-form endosseous dental implants. DATES: Submit either...

76 FR 20710 - Agency Information Collection Activities: Proposed Collection; Comments Requested: U.S. Official...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... II Controlled Substances (Accountable Forms); Order Form Requisition DEA Form 222, 222a, Controlled... Justice (DOJ), Drug Enforcement Administration (DEA), will be submitting the following information...: DEA Forms 222 and 222a. Component: Office of Diversion Control, Drug Enforcement Administration...

Three-dimensional cheese-like carbon nanoarchitecture with tremendous surface area and pore construction derived from corn as superior electrode materials for supercapacitors

NASA Astrophysics Data System (ADS)

Gopiraman, Mayakrishnan; Deng, Dian; Kim, Byoung-Suhk; Chung, Ill-Min; Kim, Ick Soo

2017-07-01

Highly porous carbon nanoarchitectures (HPCNs) were derived from biomass materials, namely, corn fibers (CF), corn leafs (CL), and corn cobs (CC). We surprisingly found that by a very simple activation process the CF, CL, and CC materials can be transformed into exciting two-dimensional (2D) and three-dimensional (3D) carbon nanoarchitectures with excellent physicochemical properties. FESEM and HRTEM results confirmed a three different carbon forms (such as foams-like carbon, carbon sheets with several holes and cheese-like carbon morphology) of HPCNs. Huge surface area (2394-3475 m2/g) with excellent pore properties of HPCNs was determined by BET analysis. Well condensed graphitic plans of HPCNs were confirmed by XRD, XPS and Raman analyses. As an electrode material, HPCNs demonstrated a maximum specific capacitance (Cs) of 575 F/g in 1.0 M H2SO4 with good stability over 20,000 cycles. The CC-700 °C showed a tremendous Cs of 375 F/g even at 20000th cycles. To the best of our knowledge, this is the highest Cs by the biomass derived activated carbons in aqueous electrolytes. The CC-700 °C exhibited excellent charge-discharge behavior at various current densities (0.5-10 A g-1). Notably, CC-700 °C demonstrated an excellent Cs of 207 F/g at current density of 10 A g-1. An extraordinary change-discharge behavior was noticed at low current density of 0.5 A g-1.

Collaborative care for depression and anxiety disorders in patients with recent cardiac events: the Management of Sadness and Anxiety in Cardiology (MOSAIC) randomized clinical trial.

PubMed

Huffman, Jeff C; Mastromauro, Carol A; Beach, Scott R; Celano, Christopher M; DuBois, Christina M; Healy, Brian C; Suarez, Laura; Rollman, Bruce L; Januzzi, James L

2014-06-01

Depression and anxiety are associated with adverse cardiovascular outcomes in patients with recent acute cardiac events. There has been minimal study of collaborative care (CC) management models for mental health disorders in high-risk cardiac inpatients, and no prior CC intervention has simultaneously managed depression and anxiety disorders. To determine the impact of a low-intensity CC intervention for depression, generalized anxiety disorder, and panic disorder among patients hospitalized for an acute cardiac illness. Single-blind randomized clinical trial, with study assessors blind to group assignment, from September 2010 through July 2013 of 183 patients admitted to inpatient cardiac units in an urban academic general hospital for acute coronary syndrome, arrhythmia, or heart failure and found to have clinical depression, generalized anxiety disorder, or panic disorder on structured assessment. Participants were randomized to 24 weeks of a low-intensity telephone-based multicomponent CC intervention targeting depression and anxiety disorders (n = 92) or to enhanced usual care (serial notification of primary medical providers; n = 91). The CC intervention used a social work care manager to coordinate assessment and stepped care of psychiatric conditions and to provide support and therapeutic interventions as appropriate. Improvement in mental health-related quality of life (Short Form-12 Mental Component Score [SF-12 MCS]) at 24 weeks, compared between groups using a random-effects model in an intent-to-treat analysis. Patients randomized to CC had significantly greater estimated mean improvements in SF-12 MCS at 24 weeks (11.21 points [from 34.21 to 45.42] in the CC group vs 5.53 points [from 36.30 to 41.83] in the control group; estimated mean difference, 5.68 points [95% CI, 2.14-9.22]; P = .002; effect size, 0.61). Patients receiving CC also had significant improvements in depressive symptoms and general functioning, and higher rates of treatment of a mental health disorder; anxiety scores, rates of disorder response, and adherence did not differ between groups. A novel telephone-based, low-intensity model to concurrently manage cardiac patients with depression and/or anxiety disorders was effective for improving mental health-related quality of life in a 24-week trial. clinicaltrials.gov Identifier: NCT01201967.

76 FR 4398 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... representative payee have been used for the annuitant's current maintenance and personal needs and whether the... complete and return Form G-99a, or in situations when the returned Form G-99a indicates the possible misuse...

76 FR 10385 - Agency Information Collection Activities: Various Contract Related Forms That Will be Included in...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... Forms That Will be Included in the Homeland Security Acquisition Regulation, DHS FORM 0700-01, DHS FORM 0700-02, DHS FORM 0700-03, DHS FORM 0700-04 AGENCY: Office of Chief Procurement Officer, Acquisition..., Acquisition Policy and Legislation Office, DHS will submit the following information collection request (ICR...

75 FR 69688 - Agency Information Collection Activities: Various Contract Related Forms That Will Be Included in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

... Forms That Will Be Included in the Homeland Security Acquisition Regulation, DHS Form 0700-01, DHS Form 0700-02, DHS Form 0700-03, DHS FORM 0700-04 AGENCY: Office of Chief Procurement Officer, Acquisition..., Acquisition Policy and Legislation Office, will submit the following Information Collection Request (ICR) to...

Tetra­kis(2,3,5,5-tetra­methyl­hexen-2-yl)silane

PubMed Central

Meyer-Wegner, Frank; Bolte, Michael; Lerner, Hans-Wolfram

2014-01-01

In the title compound, C40H76Si, the Si atom is located on a special position of site symmetry -4. Thus, there is just a quarter of a mol­ecule in the asymmetric unit. The C=C double bonds exhibit a trans configuration. The Si atom and the tert-butyl group are located on the same side of the plane formed by the C=C double bond and its four substituents. The crystal packing shows no short contacts between the mol­ecules and despite the low crystal density (0.980 Mg m−3), there are no significant voids in the structure. PMID:24765057

Development of Sidebands in Tapered and in Untapered Free-Electron Lasers

DTIC Science & Technology

1988-07-01

taken to be of the form a (r,z,t) I a(r,z,t) exp [i z - Wt e x + c.c. 2r T-r) - where A r=mec a r lei is the radiation vector potential, m is the...rest-mass of an electron, lel is the magnitude of the electronic change, c is the speed of light in vacuo, w is the radian frequency, and e is the unit-X... vector along the x axis. The wiggler field is assumed to be plane- polarized, of amplitude B and period 2rt/k : w w B (z) - B exp (ik z)e + c.c. w2w

New Results on RZ Leo and CC Scl

NASA Astrophysics Data System (ADS)

Szkody, Paula; Mukadam, Anjum S.; Gaensicke, Boris T.; Toloza, Odette; Dai, Zhibin; HST GO12870 Team

2017-01-01

Using HST COS ultraviolet spectra in time-tag mode and a long K2 observation, we have determined a spin period for the white in RZ Leo of 220 seconds, thus confirming this cataclysmic variable as a new member of the Intermediate Polar class of systems. The ultraviolet light curve of CC Scl at quiescence created from its COS spectral observations is dominated by its spin period of 195 seconds (that has only been previously observed during one of its outbursts). Spectra formed from the high and low sections of its light curve shows a temperature difference of several thousand degrees.PS and ASM acknowledge support from NASA grant HST-GO13807 and from NSF grant AST-1514737.

7 CFR 4288.20 - Submittal of applications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Assistance Program, 1400 Independence Avenue, SW., Stop 3225, Washington, DC 20250-3225. (b) Content and form... identified in Form RD 4288-4, “Repowering Assistance Program Application,” to verify compliance with program... section. (1) Form RD 4288-4. Applicants must submit this form and all necessary attachments providing...

7 CFR 4288.20 - Submittal of applications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Assistance Program, 1400 Independence Avenue, SW., Stop 3225, Washington, DC 20250-3225. (b) Content and form... identified in Form RD 4288-4, “Repowering Assistance Program Application,” to verify compliance with program... section. (1) Form RD 4288-4. Applicants must submit this form and all necessary attachments providing...

7 CFR 4288.20 - Submittal of applications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Assistance Program, 1400 Independence Avenue, SW., Stop 3225, Washington, DC 20250-3225. (b) Content and form... identified in Form RD 4288-4, “Repowering Assistance Program Application,” to verify compliance with program... section. (1) Form RD 4288-4. Applicants must submit this form and all necessary attachments providing...

49 CFR 365.503 - Application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... address provided in Form OP-1(MX). (d) You may obtain the application forms from any FMCSA Division Office.... (a) Each applicant applying under this subpart must submit an application that consists of: (1) Form.... Municipalities and Commercial Zones on the U.S.-Mexico Border; (2) Form MCS-150—Motor Carrier Identification...

75 FR 65387 - Agency Information Collection Activities: Proposed Collections; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

..., Application for Employer Reporting Internet Access and Form G-440, Report Specifications Sheet. Form BA-12 is... access is obtained, authorized employees may submit reporting forms to the RRB via the Internet. The form.... Title and Purpose of Information Collection. Railroad Service and Compensation Reports/System Access...

Diversity of Staphylococcus aureus Isolates in European Wildlife

PubMed Central

Monecke, Stefan; Gavier-Widén, Dolores; Hotzel, Helmut; Peters, Martin; Guenther, Sebastian; Lazaris, Alexandros; Loncaric, Igor; Müller, Elke; Reissig, Annett; Ruppelt-Lorz, Antje; Shore, Anna C.; Walter, Birgit; Coleman, David C.; Ehricht, Ralf

2016-01-01

Staphylococcus aureus is a well-known colonizer and cause of infection among animals and it has been described from numerous domestic and wild animal species. The aim of the present study was to investigate the molecular epidemiology of S. aureus in a convenience sample of European wildlife and to review what previously has been observed in the subject field. 124 S. aureus isolates were collected from wildlife in Germany, Austria and Sweden; they were characterized by DNA microarray hybridization and, for isolates with novel hybridization patterns, by multilocus sequence typing (MLST). The isolates were assigned to 29 clonal complexes and singleton sequence types (CC1, CC5, CC6, CC7, CC8, CC9, CC12, CC15, CC22, CC25, CC30, CC49, CC59, CC88, CC97, CC130, CC133, CC398, ST425, CC599, CC692, CC707, ST890, CC1956, ST2425, CC2671, ST2691, CC2767 and ST2963), some of which (ST2425, ST2691, ST2963) were not described previously. Resistance rates in wildlife strains were rather low and mecA-MRSA isolates were rare (n = 6). mecC-MRSA (n = 8) were identified from a fox, a fallow deer, hares and hedgehogs. The common cattle-associated lineages CC479 and CC705 were not detected in wildlife in the present study while, in contrast, a third common cattle lineage, CC97, was found to be common among cervids. No Staphylococcus argenteus or Staphylococcus schweitzeri-like isolates were found. Systematic studies are required to monitor the possible transmission of human- and livestock-associated S. aureus/MRSA to wildlife and vice versa as well as the possible transmission, by unprotected contact to animals. The prevalence of S. aureus/MRSA in wildlife as well as its population structures in different wildlife host species warrants further investigation. PMID:27992523

Diagnosing basal cell carcinoma in vivo by near-infrared Raman spectroscopy: a Principal Components Analysis discrimination algorithm

NASA Astrophysics Data System (ADS)

Silveira, Landulfo, Jr.; Silveira, Fabrício L.; Bodanese, Benito; Pacheco, Marcos Tadeu T.; Zângaro, Renato A.

2012-02-01

This work demonstrated the discrimination among basal cell carcinoma (BCC) and normal human skin in vivo using near-infrared Raman spectroscopy. Spectra were obtained in the suspected lesion prior resectional surgery. After tissue withdrawn, biopsy fragments were submitted to histopathology. Spectra were also obtained in the adjacent, clinically normal skin. Raman spectra were measured using a Raman spectrometer (830 nm) with a fiber Raman probe. By comparing the mean spectra of BCC with the normal skin, it has been found important differences in the 800-1000 cm-1 and 1250-1350 cm-1 (vibrations of C-C and amide III, respectively, from lipids and proteins). A discrimination algorithm based on Principal Components Analysis and Mahalanobis distance (PCA/MD) could discriminate the spectra of both tissues with high sensitivity and specificity.