Interactive Scripting for Analysis and Visualization of Arbitrarily Large, Disparately Located Climate Data Ensembles Using a Progressive Runtime Server

NASA Astrophysics Data System (ADS)

Christensen, C.; Summa, B.; Scorzelli, G.; Lee, J. W.; Venkat, A.; Bremer, P. T.; Pascucci, V.

2017-12-01

Massive datasets are becoming more common due to increasingly detailed simulations and higher resolution acquisition devices. Yet accessing and processing these huge data collections for scientific analysis is still a significant challenge. Solutions that rely on extensive data transfers are increasingly untenable and often impossible due to lack of sufficient storage at the client side as well as insufficient bandwidth to conduct such large transfers, that in some cases could entail petabytes of data. Large-scale remote computing resources can be useful, but utilizing such systems typically entails some form of offline batch processing with long delays, data replications, and substantial cost for any mistakes. Both types of workflows can severely limit the flexible exploration and rapid evaluation of new hypotheses that are crucial to the scientific process and thereby impede scientific discovery. In order to facilitate interactivity in both analysis and visualization of these massive data ensembles, we introduce a dynamic runtime system suitable for progressive computation and interactive visualization of arbitrarily large, disparately located spatiotemporal datasets. Our system includes an embedded domain-specific language (EDSL) that allows users to express a wide range of data analysis operations in a simple and abstract manner. The underlying runtime system transparently resolves issues such as remote data access and resampling while at the same time maintaining interactivity through progressive and interruptible processing. Computations involving large amounts of data can be performed remotely in an incremental fashion that dramatically reduces data movement, while the client receives updates progressively thereby remaining robust to fluctuating network latency or limited bandwidth. This system facilitates interactive, incremental analysis and visualization of massive remote datasets up to petabytes in size. Our system is now available for general use in the community through both docker and anaconda.

Scientific progress without increasing verisimilitude: In response to Niiniluoto.

PubMed

Rowbottom, Darrell P

2015-06-01

First, I argue that scientific progress is possible in the absence of increasing verisimilitude in science's theories. Second, I argue that increasing theoretical verisimilitude is not the central, or primary, dimension of scientific progress. Third, I defend my previous argument that unjustified changes in scientific belief may be progressive. Fourth, I illustrate how false beliefs can promote scientific progress in ways that cannot be explicated by appeal to verisimilitude. Copyright © 2015 Elsevier Ltd. All rights reserved.

Forward progress of scientific inquiry into the early father-child relationship: introduction to the special issue on very young children and their fathers.

PubMed

Bocknek, Erika L; Hossain, Ziarat; Roggman, Lori

2014-01-01

Research on fathering and the father-child relationship has made substantial progress in the most recent 15 years since the last special issue of the Infant Mental Health Journal on fathers and young children. This special issue on fathers and young children contains a series of papers exemplifying this progress, including advances in methodology-more direct assessment and more observational measures-in addition to the increasing dynamic complexity of the conceptual models used to study fathers, the diversity of fathers studied, and the growth of programs to support early father involvement. In assessing the current state of the field, special attention is given to contributions made by the papers contained in this special issue, and two critical areas for continued progress are addressed: (1) methodological and measurement development that specifically address fathers and fathering relationships and (2) cross-cultural and ecologically valid research examining the diversity of models of fathering. © 2014 Michigan Association for Infant Mental Health.

PACE Continuous Innovation Indicators-a novel tool to measure progress in cancer treatments.

PubMed

Paddock, Silvia; Brum, Lauren; Sorrow, Kathleen; Thomas, Samuel; Spence, Susan; Maulbecker-Armstrong, Catharina; Goodman, Clifford; Peake, Michael; McVie, Gordon; Geipel, Gary; Li, Rose

2015-01-01

Concerns about rising health care costs and the often incremental nature of improvements in health outcomes continue to fuel intense debates about 'progress' and 'value' in cancer research. In times of tightening fiscal constraints, it is increasingly important for patients and their representatives to define what constitutes 'value' to them. It is clear that diverse stakeholders have different priorities. Harmonisation of values may be neither possible nor desirable. Stakeholders lack tools to visualise or otherwise express these differences and to track progress in cancer treatments based on variable sets of values. The Patient Access to Cancer care Excellence (PACE) Continuous Innovation Indicators are novel, scientifically rigorous progress trackers that employ a three-step process to quantify progress in cancer treatments: 1) mine the literature to determine the strength of the evidence supporting each treatment; 2) allow users to weight the analysis according to their priorities and values; and 3) calculate Evidence Scores (E-Scores), a novel measure to track progress, based on the strength of the evidence weighted by the assigned value. We herein introduce a novel, flexible value model, show how the values from the model can be used to weight the evidence from the scientific literature to obtain E-Scores, and illustrate how assigning different values to new treatments influences the E-Scores. The Indicators allow users to learn how differing values lead to differing assessments of progress in cancer research and to check whether current incentives for innovation are aligned with their value model. By comparing E-Scores generated by this tool, users are able to visualise the relative pace of innovation across areas of cancer research and how stepwise innovation can contribute to substantial progress against cancer over time. Learning from experience and mapping current unmet needs will help to support a broad audience of stakeholders in their efforts to accelerate and maximise progress against cancer.

Recent directions taken in water, energy, and biogeochemical budgets research

USGS Publications Warehouse

Lins, Harry F.

1994-01-01

Understanding and predicting global change is a major scientific focus of the late 20th century. Although atmospheric scientists have made substantial progress in developing models that account for many components of the climate system, significant progress is needed in understanding processes associated with the exchange of water, energy, and carbon between terrestrial systems and the atmosphere.To strengthen terrestrial process research, especially research associated with the interactions of water, energy, gases, nutrients, and vegetation, the U.S. Geological Survey initiated an intensive study of Water, Energy, and Biogeochemical Budgets (WEBB). WEBB is aimed at improving understanding of processes controlling terrestrial water, energy, and biogeochemical fluxes, their interactions, and their relations to climatic variables; and the ability to predict continental water, energy, and biogeochemical budgets over a range of spatial and temporal scales.

Veritas filia temporis: The origins of the idea of scientific progress.

PubMed

Špelda, Daniel

2016-10-01

The article provides insight into the epistemological and anthropological aspect of the origination of the idea of scientific progress. It focuses on the relationship between individual's limited lifetime and the immensity of nature. The basic assumption is that the idea of scientific progress offers a solution of the epistemological problem stemming from the finding that there is no (teleological) coincidence between human cognitive abilities and the extent of nature. In order to facilitate the understanding of the origin of the idea of scientific progress, I propose distinction between the descriptive and prescriptive concepts of progress. While the descriptive notion of progress expresses the cumulative character of scientific knowledge and the superiority of the present over preceding generations, the prescriptive concept pertains to progressivist epistemology directing scientific research at the future development of knowledge. This article claims that the prevalent concept in Antiquity was the descriptive concept of scientific progress. The prescriptive notion had developed only in ancient astronomy. Early modern science was faced with similar issues as ancient astronomy - mainly the empirical finding related to the inexhaustible character of nature. Consequently to the introduction of the idea of progress, the progress of sciences became a purpose in itself - hence becoming infinite.

2006 critical review - health effects of fine particulate air pollution: lines that connect

DOE Office of Scientific and Technical Information (OSTI.GOV)

C. Arden Pope III; Douglas W. Dockery

2006-06-15

Efforts to understand and mitigate the health effects of particulate matter (PM) air pollution have a rich and interesting history. This review focuses on six substantial lines of research that have been pursued since 1997 that have helped elucidate our understanding about the effects of PM on human health. There has been substantial progress in the evaluation of PM health effects at different time-scales of exposure and in the exploration of the shape of the concentration-response function. There has also been emerging evidence of PM-related cardiovascular health effects and growing knowledge regarding interconnected general pathophysiological pathways that link PM exposuremore » with cardiopulmonary morbidity and mortality. Despite important gaps in scientific knowledge and continued reasons for some skepticism, a comprehensive evaluation of the research findings provides persuasive evidence that exposure to fine particulate air pollution has adverse effects on cardiopulmonary health. Although much of this research has been motivated by environmental public health policy, these results have important scientific, medical, and public health implications that are broader than debates over legally mandated air quality standards. 502 refs., 4 figs., 7 tabs.« less

PACE Continuous Innovation Indicators—a novel tool to measure progress in cancer treatments

PubMed Central

Paddock, Silvia; Brum, Lauren; Sorrow, Kathleen; Thomas, Samuel; Spence, Susan; Maulbecker-Armstrong, Catharina; Goodman, Clifford; Peake, Michael; McVie, Gordon; Geipel, Gary; Li, Rose

2015-01-01

Concerns about rising health care costs and the often incremental nature of improvements in health outcomes continue to fuel intense debates about ‘progress’ and ‘value’ in cancer research. In times of tightening fiscal constraints, it is increasingly important for patients and their representatives to define what constitutes ’value’ to them. It is clear that diverse stakeholders have different priorities. Harmonisation of values may be neither possible nor desirable. Stakeholders lack tools to visualise or otherwise express these differences and to track progress in cancer treatments based on variable sets of values. The Patient Access to Cancer care Excellence (PACE) Continuous Innovation Indicators are novel, scientifically rigorous progress trackers that employ a three-step process to quantify progress in cancer treatments: 1) mine the literature to determine the strength of the evidence supporting each treatment; 2) allow users to weight the analysis according to their priorities and values; and 3) calculate Evidence Scores (E-Scores), a novel measure to track progress, based on the strength of the evidence weighted by the assigned value. We herein introduce a novel, flexible value model, show how the values from the model can be used to weight the evidence from the scientific literature to obtain E-Scores, and illustrate how assigning different values to new treatments influences the E-Scores. The Indicators allow users to learn how differing values lead to differing assessments of progress in cancer research and to check whether current incentives for innovation are aligned with their value model. By comparing E-Scores generated by this tool, users are able to visualise the relative pace of innovation across areas of cancer research and how stepwise innovation can contribute to substantial progress against cancer over time. Learning from experience and mapping current unmet needs will help to support a broad audience of stakeholders in their efforts to accelerate and maximise progress against cancer. PMID:25624879

Scientific progress: Knowledge versus understanding.

PubMed

Dellsén, Finnur

2016-04-01

What is scientific progress? On Alexander Bird's epistemic account of scientific progress, an episode in science is progressive precisely when there is more scientific knowledge at the end of the episode than at the beginning. Using Bird's epistemic account as a foil, this paper develops an alternative understanding-based account on which an episode in science is progressive precisely when scientists grasp how to correctly explain or predict more aspects of the world at the end of the episode than at the beginning. This account is shown to be superior to the epistemic account by examining cases in which knowledge and understanding come apart. In these cases, it is argued that scientific progress matches increases in scientific understanding rather than accumulations of knowledge. In addition, considerations having to do with minimalist idealizations, pragmatic virtues, and epistemic value all favor this understanding-based account over its epistemic counterpart. Copyright © 2016 Elsevier Ltd. All rights reserved.

The International AIDS Vaccine Initiative's Capacity Building Activities in East Africa

PubMed Central

Cochrane, Gavin; Robin, Enora; Hanlin, Rebecca; Castle-Clarke, Sophie; MacLure, Calum; Parks, Sarah; Chataway, Joanna

2016-01-01

Abstract The International AIDS Vaccine Initiative (IAVI) is one of a number of Product Development Partnerships created to bridge the gap between scientific and technological potential and the needs of low income populations in low and middle income countries. Specifically IAVI is focused on creating a preventative vaccine for HIV/AIDS. Whilst the remit of IAVI is to create new science, technology and products, its work necessarily involves a wide range of stakeholders and different constituencies in industrially developing and developed countries. Its capacity building activities relate to strengthening the ability to conduct clinical trials and are broad based, spanning scientific and technological capacity through to organisational, advocacy and broader development capabilities. The aim of this study was to deepen IAVI's understanding of how it contributes to capacity building activities in East Africa (Uganda, Kenya and Rwanda), spanning scientific and technological capacity through to organisational, advocacy and broader development capabilities. IAVI's mission to develop an HIV vaccine has become increasingly connected to wider health systems strengthening, through its clinical research activities in East Africa. Since it began its operations in the region, IAVI has made a significant contribution to training interventions to support scientific excellence and good clinical practice and invested in infrastructure and laboratories at Clinical Research Centres in East Africa. Although clear challenges still exist with ensuring sustained investment, accessing marginalized populations and demonstrating progress in capacity building, the experiences of IAVI to date suggest that substantial progress is being made towards wider health systems strengthening in the region. PMID:28083400

10 CFR 725.15 - Requirements for approval of applications.

Code of Federal Regulations, 2011 CFR

2011-01-01

... engaged in a substantial effort to develop, design, build or operate a chemical processing plant or other... (b)(2)(i) of this section, substantial scientific, engineering or other professional services to be... the paragraph (b)(3)(i) of this section substantial scientific, engineering, or other professional...

Preventing HIV infection in women.

PubMed

Adimora, Adaora A; Ramirez, Catalina; Auerbach, Judith D; Aral, Sevgi O; Hodder, Sally; Wingood, Gina; El-Sadr, Wafaa; Bukusi, Elizabeth A

2013-07-01

Although the number of new infections has declined recently, women still constitute almost half of the world's 34 million people with HIV infection, and HIV remains the leading cause of death among women of reproductive age. Prevention research has made considerable progress during the past few years in addressing the biological, behavioral, and social factors that influence women's vulnerability to HIV infection. Nevertheless, substantial work still must be performed to implement scientific advancements and to resolve many questions that remain. This article highlights some of the recent advances and persistent gaps in HIV prevention research for women and outlines key research and policy priorities.

[The detection and cultivation of the scientific talent of young doctors].

PubMed

Van Der Meer, J W M

2005-01-01

Although science is not a key issue for the general public in The Netherlands, and scouting talents is not a customary activity, it is of the utmost importance for the scientific progress to detect gifted young people and to motivate them for a career in medical sciences. The scouting of talent should start as early as possible. A working group of the Royal Netherlands Academy of Arts and Sciences has issued a report on secondary schooling in which scouting of talent is a central issue. The modern medical curricula at the universities in The Netherlands all offer a substantial elective programme and the modern teaching in small groups also offers opportunities for teachers to detect talent. Recognition of scientific talent is further possible during the research period that every medical student has to go through. In Nijmegen, the Department of Internal Medicine organises a yearly master class at the end of the summer for the best second year medical students; in this course they are introduced to the scientific approach in medicine: from bedside to bench and vice versa. With this course we try to enforce the motivation for medical research. A prime instrument for the development of scientific talent is the nationally funded PhD track for medical specialists in training.

Using Data Maturity Metrics to Help Insure Scientific Integrity

NASA Astrophysics Data System (ADS)

Bates, J. J.

2016-12-01

In the past few years, the full and open sharing of data and other artifacts of research in the geophysics have become mandatory. These include commitments from scientific societies, calls from international organizations, and in the United States, Executive Orders and legislation for open data. Unfortunately, these calls for open data have had, at best, mixed results. Audits by publishers indicate most who do not comply with are unaware of the policies or simply ignore them. A recent high profile publication on global warming resulted in repeated demands of `all data' from Congress and a prolonged back and forth on what `all data' meant. The emerging field of Data Management Maturity is making substantial progress on quantifying the elements needed to fully document, and making open and accessible, geophysical data sets. The proposed metrics have been culled from best practices for observational data sets and these metrics have been applied to a number of geophysical disciplines. A case study applying this metric to climate change indicators will be presented. It is recommended that U.S. Agencies and scientific societies formally adopt data maturity metrics to help ensure a consistent approach to ensure open data and scientific integrity.

Scientific Performance of a Nano-satellite MeV Telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lucchetta, Giulio; Berlato, Francesco; Rando, Riccardo

Over the past two decades, both X-ray and gamma-ray astronomy have experienced great progress. However, the region of the electromagnetic spectrum around ∼1 MeV is not so thoroughly explored. Future medium-sized gamma-ray telescopes will fill this gap in observations. As the timescale for the development and launch of a medium-class mission is ∼10 years, with substantial costs, we propose a different approach for the immediate future. In this paper, we evaluate the viability of a much smaller and cheaper detector: a nano-satellite Compton telescope, based on the CubeSat architecture. The scientific performance of this telescope would be well below thatmore » of the instrument expected for the future larger missions; however, via simulations, we estimate that such a compact telescope will achieve a performance similar to that of COMPTEL.« less

Plan for Living on a Restless Planet Sets NASA's Solid Earth Agenda

NASA Astrophysics Data System (ADS)

Solomon, Sean C.; Baker, Victor R.; Bloxham, Jeremy; Booth, Jeffrey; Donnellan, Andrea; Elachi, Charles; Evans, Diane; Rignot, Eric; Burbank, Douglas; Chao, Benjamin F.; Chave, Alan; Gillespie, Alan; Herring, Thomas; Jeanloz, Raymond; LaBrecque, John; Minster, Bernard; Pittman, Walter C., III; Simons, Mark; Turcotte, Donald L.; Zoback, Mary Lou C.

What are the most important challenges facing solid Earth science today and over the next two decades? And what is the best approach for NASA, in partnership with other agencies, to address those challenges? A new report, Living on a Restless Planet, provides a blueprint for answering these questions. The top priority for a new spacecraft mission in the area of solid Earth science over the next 5 years, according to this report, is a satellite dedicated to Interferometric Synthetic Aperture Radar (InSAR). At the request of NASA, the Solid Earth Science Working Group (SESWG) developed a strategy for the highest priority objectives in solid Earth science for the space agency over the next 25 years. The strategy addresses six challenges that are of fundamental scientific importance, have strong implications for society, and are amenable to substantial progress through a concerted series of scientific observations from space.

Hyphenated hydrology: Multidisciplinary evolution of water resource science

NASA Astrophysics Data System (ADS)

McCurley, K. 4553; Jawitz, J. W.

2016-12-01

Hydrology has advanced considerably as a scientific discipline since its recognized inception in the mid-20th century. While hydrology may have evolved from the singular viewpoint of a more rigid physical or engineering science, modern water resource related questions have forced adaptation toward a deliberate interdisciplinary context. Over the past few decades, many of the eventual manifestations of this evolution have been foreseen by prominent expert hydrologists, though their narrative descriptions were not substantially quantified. This study addresses that gap by directly measuring and inspecting the words that hydrologists use to define and describe their research endeavors. We analyzed 16,591 journal article titles from 1965-2015 in Water Resources Research, through which the scientific dialogue and its time-sensitive progression emerges. Word frequency and term concurrence reveal the dynamic timing of the lateral movement of hydrology across multiple disciplines and a deepening of scientific discourse with respect to traditional hydrologic questions. This study concludes that formerly exotic disciplines are increasingly modifying hydrology, prompting new insights as well as inspiring unconventional perspectives on old questions.

Antiretroviral drug regimens to prevent mother-to-child transmission of HIV: a review of scientific, program, and policy advances for sub-Saharan Africa.

PubMed

Chi, Benjamin H; Stringer, Jeffrey S A; Moodley, Dhayendre

2013-06-01

Considerable advances have been made in the effort to prevent mother-to-child HIV transmission (PMTCT) in sub-Saharan Africa. Clinical trials have demonstrated the efficacy of antiretroviral regimens to interrupt HIV transmission through the antenatal, intrapartum, and postnatal periods. Scientific discoveries have been rapidly translated into health policy, bolstered by substantial investment in health infrastructure capable of delivering increasingly complex services. A new scientific agenda is also emerging, one that is focused on the challenges of effective and sustainable program implementation. Finally, global campaigns to "virtually eliminate" pediatric HIV and dramatically reduce HIV-related maternal mortality have mobilized new resources and renewed political will. Each of these developments marks a major step in regional PMTCT efforts; their convergence signals a time of rapid progress in the field, characterized by an increased interdependency between clinical research, program implementation, and policy. In this review, we take stock of recent advances across each of these areas, highlighting the challenges--and opportunities--of improving health services for HIV-infected mothers and their children across the region.

[The dermatological indications of laser: beyond cosmetic target.

PubMed

Abosaleh, Marem; Boehncke, Wolf-Henning; Laubach, Hans

2017-01-11

During the last 30 years, the use of lasers in dermatology has gone far beyond the spectrum of aesthetic and cosmetic applications. Techniques are more than simple removal by CO2 Laser. Increasing knowledge, understanding, and experience have helped to effectively treat numerous important skin diseaes by the use of lasers. However, high-quality clinical trials are sparse in this domain. Consequently, so far only the treatment of hemangiomas and warts is a laser indication reimbursed by insurance companies. This article discusses three types of skin diseases where substantial progress has been reported in the scientific literature in 2016, namely pigmentary disorders, vascular diseases, and inflammatory dermatoses.

Preventing HIV Infection in Women

PubMed Central

Adimora, Adaora A.; Ramirez, Catalina; Auerbach, Judith D.; Aral, Sevgi O.; Hodder, Sally; Wingood, Gina; El-Sadr, Wafaa; Bukusi, Elizabeth Anne

2014-01-01

Although the number of new infections has declined recently, women still constitute almost half of the world's 34 million people with HIV infection, and HIV remains the leading cause of death among women of reproductive age. Prevention research has made considerable progress during the past few years in addressing the biological, behavioral and social factors that influence women's vulnerability to HIV infection. Nevertheless, substantial work still must be done in order to implement scientific advancements and to resolve the many questions that remain. This article highlights some of the recent advances and persistent gaps in HIV prevention research for women and outlines key research and policy priorities. PMID:23764631

The current state of Bayesian methods in medical product development: survey results and recommendations from the DIA Bayesian Scientific Working Group.

PubMed

Natanegara, Fanni; Neuenschwander, Beat; Seaman, John W; Kinnersley, Nelson; Heilmann, Cory R; Ohlssen, David; Rochester, George

2014-01-01

Bayesian applications in medical product development have recently gained popularity. Despite many advances in Bayesian methodology and computations, increase in application across the various areas of medical product development has been modest. The DIA Bayesian Scientific Working Group (BSWG), which includes representatives from industry, regulatory agencies, and academia, has adopted the vision to ensure Bayesian methods are well understood, accepted more broadly, and appropriately utilized to improve decision making and enhance patient outcomes. As Bayesian applications in medical product development are wide ranging, several sub-teams were formed to focus on various topics such as patient safety, non-inferiority, prior specification, comparative effectiveness, joint modeling, program-wide decision making, analytical tools, and education. The focus of this paper is on the recent effort of the BSWG Education sub-team to administer a Bayesian survey to statisticians across 17 organizations involved in medical product development. We summarize results of this survey, from which we provide recommendations on how to accelerate progress in Bayesian applications throughout medical product development. The survey results support findings from the literature and provide additional insight on regulatory acceptance of Bayesian methods and information on the need for a Bayesian infrastructure within an organization. The survey findings support the claim that only modest progress in areas of education and implementation has been made recently, despite substantial progress in Bayesian statistical research and software availability. Copyright © 2013 John Wiley & Sons, Ltd.

42 CFR 82.30 - How will NIOSH inform the public of any plans to change scientific elements underlying the dose...

Code of Federal Regulations, 2012 CFR

2012-10-01

... change scientific elements underlying the dose reconstruction process to maintain methods reasonably current with scientific progress? 82.30 Section 82.30 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... methods reasonably current with scientific progress? Periodically, NIOSH will publish a notice in the...

42 CFR 82.30 - How will NIOSH inform the public of any plans to change scientific elements underlying the dose...

Code of Federal Regulations, 2011 CFR

2011-10-01

... change scientific elements underlying the dose reconstruction process to maintain methods reasonably current with scientific progress? 82.30 Section 82.30 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... methods reasonably current with scientific progress? Periodically, NIOSH will publish a notice in the...

42 CFR 82.30 - How will NIOSH inform the public of any plans to change scientific elements underlying the dose...

Code of Federal Regulations, 2013 CFR

2013-10-01

... change scientific elements underlying the dose reconstruction process to maintain methods reasonably current with scientific progress? 82.30 Section 82.30 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... methods reasonably current with scientific progress? Periodically, NIOSH will publish a notice in the...

42 CFR 82.30 - How will NIOSH inform the public of any plans to change scientific elements underlying the dose...

Code of Federal Regulations, 2014 CFR

2014-10-01

... change scientific elements underlying the dose reconstruction process to maintain methods reasonably current with scientific progress? 82.30 Section 82.30 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... methods reasonably current with scientific progress? Periodically, NIOSH will publish a notice in the...

A warning to the Brazilian Speech-Language Pathology and Audiology community about the importance of scientific and clinical activities in primary progressive aphasia.

PubMed

Beber, Bárbara Costa; Brandão, Lenisa; Chaves, Márcia Lorena Fagundes

2015-01-01

This article aims to warn the Brazilian Speech-Language Pathology and Audiology scientific community about the importance and necessity of scientific and clinical activities regarding Primary Progressive Aphasia. This warning is based on a systematic literature review of the scientific production on Primary Progressive Aphasia, from which nine Brazilian articles were selected. It was observed that there is an obvious lack of studies on the subject, as all the retrieved articles were published in medical journals and much of it consisted of small samples; only two articles described the effectiveness of speech-language therapy in patients with Primary Progressive Aphasia. A perspective for the future in the area and characteristics of Speech-Language Therapy for Primary Progressive Aphasia are discussed. As a conclusion, it is evident the need for greater action by Speech-Language Pathology and Audiology on Primary Progressive Aphasia.

On disciplinary fragmentation and scientific progress.

PubMed

Balietti, Stefano; Mäs, Michael; Helbing, Dirk

2015-01-01

Why are some scientific disciplines, such as sociology and psychology, more fragmented into conflicting schools of thought than other fields, such as physics and biology? Furthermore, why does high fragmentation tend to coincide with limited scientific progress? We analyzed a formal model where scientists seek to identify the correct answer to a research question. Each scientist is influenced by three forces: (i) signals received from the correct answer to the question; (ii) peer influence; and (iii) noise. We observed the emergence of different macroscopic patterns of collective exploration, and studied how the three forces affect the degree to which disciplines fall apart into divergent fragments, or so-called "schools of thought". We conducted two simulation experiments where we tested (A) whether the three forces foster or hamper progress, and (B) whether disciplinary fragmentation causally affects scientific progress and vice versa. We found that fragmentation critically limits scientific progress. Strikingly, there is no effect in the opposite causal direction. What is more, our results shows that at the heart of the mechanisms driving scientific progress we find (i) social interactions, and (ii) peer disagreement. In fact, fragmentation is increased and progress limited if the simulated scientists are open to influence only by peers with very similar views, or when within-school diversity is lost. Finally, disciplines where the scientists received strong signals from the correct answer were less fragmented and experienced faster progress. We discuss model's implications for the design of social institutions fostering interdisciplinarity and participation in science.

On Disciplinary Fragmentation and Scientific Progress

PubMed Central

Balietti, Stefano; Mäs, Michael; Helbing, Dirk

2015-01-01

Why are some scientific disciplines, such as sociology and psychology, more fragmented into conflicting schools of thought than other fields, such as physics and biology? Furthermore, why does high fragmentation tend to coincide with limited scientific progress? We analyzed a formal model where scientists seek to identify the correct answer to a research question. Each scientist is influenced by three forces: (i) signals received from the correct answer to the question; (ii) peer influence; and (iii) noise. We observed the emergence of different macroscopic patterns of collective exploration, and studied how the three forces affect the degree to which disciplines fall apart into divergent fragments, or so-called “schools of thought”. We conducted two simulation experiments where we tested (A) whether the three forces foster or hamper progress, and (B) whether disciplinary fragmentation causally affects scientific progress and vice versa. We found that fragmentation critically limits scientific progress. Strikingly, there is no effect in the opposite causal direction. What is more, our results shows that at the heart of the mechanisms driving scientific progress we find (i) social interactions, and (ii) peer disagreement. In fact, fragmentation is increased and progress limited if the simulated scientists are open to influence only by peers with very similar views, or when within-school diversity is lost. Finally, disciplines where the scientists received strong signals from the correct answer were less fragmented and experienced faster progress. We discuss model’s implications for the design of social institutions fostering interdisciplinarity and participation in science. PMID:25790025

Genetics and Genomics of Coronary Artery Disease.

PubMed

Pjanic, Milos; Miller, Clint L; Wirka, Robert; Kim, Juyong B; DiRenzo, Daniel M; Quertermous, Thomas

2016-10-01

Coronary artery disease (or coronary heart disease), is the leading cause of mortality in many of the developing as well as the developed countries of the world. Cholesterol-enriched plaques in the heart's blood vessels combined with inflammation lead to the lesion expansion, narrowing of blood vessels, reduced blood flow, and may subsequently cause lesion rupture and a heart attack. Even though several environmental risk factors have been established, such as high LDL-cholesterol, diabetes, and high blood pressure, the underlying genetic composition may substantially modify the disease risk; hence, genome composition and gene-environment interactions may be critical for disease progression. Ongoing scientific efforts have seen substantial advancements related to the fields of genetics and genomics, with the major breakthroughs yet to come. As genomics is the most rapidly advancing field in the life sciences, it is important to present a comprehensive overview of current efforts. Here, we present a summary of various genetic and genomics assays and approaches applied to coronary artery disease research.

Strategy for earth explorers in global earth sciences

NASA Technical Reports Server (NTRS)

1988-01-01

The goal of the current NASA Earth System Science initiative is to obtain a comprehensive scientific understanding of the Earth as an integrated, dynamic system. The centerpiece of the Earth System Science initiative will be a set of instruments carried on polar orbiting platforms under the Earth Observing System program. An Earth Explorer program can open new vistas in the earth sciences, encourage innovation, and solve critical scientific problems. Specific missions must be rigorously shaped by the demands and opportunities of high quality science and must complement the Earth Observing System and the Mission to Planet Earth. The committee believes that the proposed Earth Explorer program provides a substantial opportunity for progress in the earth sciences, both through independent missions and through missions designed to complement the large scale platforms and international research programs that represent important national commitments. The strategy presented is intended to help ensure the success of the Earth Explorer program as a vital stimulant to the study of the planet.

The "participating victim" in the study of erotic experiences between children and adults: an historical analysis.

PubMed

Malón, Agustín

2011-02-01

During the 20th century, erotic experiences between minors and adults occupied a position of increasing interest, both public as well as scientific. In this area of research, one of the most notable evolutions in how these experiences are treated has been the progressive disappearance and/or the intense redefinition of what earlier researchers called "participating victims," i.e., minors apparently interested in accepting and/or sustaining these relationships. The present work, through a comparative analysis of the literature, seeks to substantiate this transformation during the second third of the 20th century. It will also argue that this evolution can be fundamentally explained in terms of the intense emotional, moral, and ideological importance that is ascribed to these experiences in the rise of the current victimological paradigm. Finally, this study endeavors to contribute to the understanding of childhood and the scientific study of child sexuality as well as of these experiences with adults.

77 FR 1668 - Endangered and Threatened Species; 90-Day Finding on Petition To Delist the Southern Oregon...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-11

... presents substantial scientific or commercial information to list or delist a species, we take into account... that the petition does not present substantial scientific or commercial information indicating that the..., Southwest Regional Office, 501 West Ocean Blvd., Suite 4200, Long Beach, CA 90802. FOR FURTHER INFORMATION...

Progress in Scientific and Technical Communications, 1968 Annual Report.

ERIC Educational Resources Information Center

Federal Council for Science and Technology, Washington, DC. Committee on Scientific and Technical Information.

This sixth annual report describes progress achieved by the Federal Government in improving the communication of scientific and technical information to support and enhance national science and technology. Included in the report are details regarding the scientific and technical activities of individual Federal Agencies, such as the Atomic Energy…

[Between sancticity and value of human life: in perspective of human cloning].

PubMed

Dyk, W

2001-01-01

The more we know, the more duties and greater responsibility we have. The dynamic development of biology carries a lot of hope for the freeing of mankind from genetic diseases. But the introduction of scientific thought necessarily has to be bound with the development of technology. It is wrong when technology dictates science a direction of development; when technique comes before ethics; and when technology does not respect the essence of a human being. The uncritical introduction of eugenics, especially cloning of people and rejecting all moral arguments, recalls inglorious acts of science when the ideology of progress determined the range of problems that researchers focused on. The same ideology of progress, although originating from other sources, pushes science toward a second extreme, into utilitarianism. In the article the author wishes to substantiate the necessity for researchers to respect ethical norms. Recognition of natural laws alone does not provide science with full development if the rights of conscience are violated.

Scientific Considerations for Future Spectroscopic Measurements from Space of Activity on the Sun

NASA Technical Reports Server (NTRS)

Holman, Gordon D.

2016-01-01

High-resolution UV and X-ray spectroscopy are important to understanding the origin and evolution of magnetic energy release in the solar atmosphere, as well as the subsequent evolution of heated plasma and accelerated particles. Electromagnetic radiation is observed from plasma heated to temperatures ranging from about 10 k K to above 10 MK, from accelerated electrons emitting photons primarily at X-ray energies, and from ions emitting in gamma rays. These observations require space-based instruments sensitive to emissions at wavelengths shorter than the near UV. This article reviews some recent observations with emphasis on solar eruptive events, the models that describe them, and the measurements they indicate are needed for substantial progress in the future. Specific examples are discussed demonstrating that imaging spectroscopy with a cadence of seconds or better is needed to follow, understand, and predict the evolution of solar activity. Critical to substantial progress is the combination of a judicious choice of UV, EUV, and soft X-ray imaging spectroscopy sensitive to the evolution of this thermal plasma combined with hard X-ray imaging spectroscopy sensitive to suprathermal electrons. The major challenge will be to conceive instruments that, within the bounds of possible technologies and funding, have the flexibility and field of view to obtain spectroscopic observations where and when events occur while providing an optimum balance of dynamic range, spectral resolution and range, and spatial resolution.

PASSCLAIM - Synthesis and review of existing processes.

PubMed

Richardson, David P; Affertsholt, Tage; Asp, Nils-Georg; Bruce, Ake; Grossklaus, Rolf; Howlett, John; Pannemans, Daphne; Ross, Richard; Verhagen, Hans; Viechtbauer, Volker

2003-03-01

Several approaches to the use of health claims on foods have been made around the world, and the common theme is that any health claim will require scientific validation and substantiation. There is also broad consensus that any regulatory framework should protect the consumer, promote fair trade and encourage innovation in the food industry.This paper is based on a critical evaluation of existing international approaches to the scientific substantiation of health claims, with a view to identifying common new ideas, definitions, best practice and a methodology to underpin current and future developments. There is a clear need to have uniform understanding, terminology and description of types of nutrition and health claims. Two broad categories were defined: Nutrition Claims, i. e. what the product contains, and Health Claims, i. e. relating to health, well-being and/or performance, including well-established nutrient function claims, enhanced function claims and disease risk reduction claims. Such health claims relate to what the food or food components does or do. The categories of health claims are closely and progressively related and are, in practice, part of a continuum. Provision is also made for "generic" or well-established, generally accepted claims and for "innovative" or "product-specific" claims. Special attention was paid to reflect the health-promoting properties of a food or food component in such a way as to facilitate the making of risk reduction claims outside the medical scope of the term prevention. The paper sets out basic principles and guidelines for communication of health claims and principles of nutritional safety. The main body of the work examines the process for the assessment of scientific support for health claims on food and emphasises an evidence-based approach consisting of: Identification of all relevant studies exploring the collection of evidence, data searches, the nature of the scientific evidence, sources of scientific data (including human intervention studies, human observational studies, animal studies and in vitro studies, and the use of biomarkers in human studies. Evaluation of the quality of individual studies to ensure good experimental design and interpretation. Interpretation of the totality of evidence to apply scientific judgement to interpret the weight of evidence as a whole. Assessment of significant scientific agreement on a case-by-case basis to agree within the relevant scientific community that an association between a food or a food component and a health benefit is valid. Annexes include an international comparison of regulatory approaches to health claims, suggestions for the documentation and presentation of evidence, and a procedure for reviewing the evidence.

76 FR 55638 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Snowy...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

...-0059; MO 92210-0-0008] Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To... the petition does not present substantial scientific or commercial information indicating that the... a petition to list, delist, or reclassify a species presents substantial scientific or commercial...

How new concepts become universal scientific approaches: insights from citation network analysis of agent-based complex systems science.

PubMed

Vincenot, Christian E

2018-03-14

Progress in understanding and managing complex systems comprised of decision-making agents, such as cells, organisms, ecosystems or societies, is-like many scientific endeavours-limited by disciplinary boundaries. These boundaries, however, are moving and can actively be made porous or even disappear. To study this process, I advanced an original bibliometric approach based on network analysis to track and understand the development of the model-based science of agent-based complex systems (ACS). I analysed research citations between the two communities devoted to ACS research, namely agent-based (ABM) and individual-based modelling (IBM). Both terms refer to the same approach, yet the former is preferred in engineering and social sciences, while the latter prevails in natural sciences. This situation provided a unique case study for grasping how a new concept evolves distinctly across scientific domains and how to foster convergence into a universal scientific approach. The present analysis based on novel hetero-citation metrics revealed the historical development of ABM and IBM, confirmed their past disjointedness, and detected their progressive merger. The separation between these synonymous disciplines had silently opposed the free flow of knowledge among ACS practitioners and thereby hindered the transfer of methodological advances and the emergence of general systems theories. A surprisingly small number of key publications sparked the ongoing fusion between ABM and IBM research. Beside reviews raising awareness of broad-spectrum issues, generic protocols for model formulation and boundary-transcending inference strategies were critical means of science integration. Accessible broad-spectrum software similarly contributed to this change. From the modelling viewpoint, the discovery of the unification of ABM and IBM demonstrates that a wide variety of systems substantiate the premise of ACS research that microscale behaviours of agents and system-level dynamics are inseparably bound. © 2018 The Author(s).

Mavericks versus team players: the trade-off between shared glory and making a personal contribution.

PubMed

Charlton, Bruce G

2008-08-01

The modern world is characterized by progressive specialization of function and ever-larger-scale coordination of these ever-more-specialized functions. More and more of science is done by increasing-sized teams of specialists, and the ability to engage in 'teamwork' is regarded as an almost essential attribute for most scientists. But teamwork does not suit all personality types. Some 'maverick' individuals would rather have personal credit for a relatively modest scientific contribution which they achieved (mostly) by themselves, than a share of credit in a much larger scientific contribution generated by a large team. The present system of medical science is organized to discourage mavericks and, on the whole, this is probably justifiable on the basis that scientists are not natural team players. Extra inducements are necessary to get people to adopt the relatively self-effacing behaviours necessary for building the large organizations of complementary specialists that are necessary for tackling many of the most intractable modern scientific problems. However, an ethos of teamwork does carry substantial disadvantages. Although most scientists are dispensable, and do not make a significant personal contribution, the very best scientists do make a difference to the rate of progress of science. And top notch scientists are wasted as team players. The very best scientists can function only as mavericks because they are doing science for vocational reasons. The highest intensity of personal commitment requires individual rewards from distinctive contributions. In conclusion, the current incentive system that encourages teamwork involves a trade-off. The majority of modestly talented scientists can probably achieve more when working as members of a team. But the very best scientists probably need to work as mavericks.

Taming theory with thought experiments: Understanding and scientific progress.

PubMed

Stuart, Michael T

2016-08-01

I claim that one way thought experiments contribute to scientific progress is by increasing scientific understanding. Understanding does not have a currently accepted characterization in the philosophical literature, but I argue that we already have ways to test for it. For instance, current pedagogical practice often requires that students demonstrate being in either or both of the following two states: 1) Having grasped the meaning of some relevant theory, concept, law or model, 2) Being able to apply that theory, concept, law or model fruitfully to new instances. Three thought experiments are presented which have been important historically in helping us pass these tests, and two others that cause us to fail. Then I use this operationalization of understanding to clarify the relationships between scientific thought experiments, the understanding they produce, and the progress they enable. I conclude that while no specific instance of understanding (thus conceived) is necessary for scientific progress, understanding in general is. Copyright © 2016 Elsevier Ltd. All rights reserved.

Distinguishing time-delayed causal interactions using convergent cross mapping

PubMed Central

Ye, Hao; Deyle, Ethan R.; Gilarranz, Luis J.; Sugihara, George

2015-01-01

An important problem across many scientific fields is the identification of causal effects from observational data alone. Recent methods (convergent cross mapping, CCM) have made substantial progress on this problem by applying the idea of nonlinear attractor reconstruction to time series data. Here, we expand upon the technique of CCM by explicitly considering time lags. Applying this extended method to representative examples (model simulations, a laboratory predator-prey experiment, temperature and greenhouse gas reconstructions from the Vostok ice core, and long-term ecological time series collected in the Southern California Bight), we demonstrate the ability to identify different time-delayed interactions, distinguish between synchrony induced by strong unidirectional-forcing and true bidirectional causality, and resolve transitive causal chains. PMID:26435402

Promoting Innovative Thinking

PubMed Central

2015-01-01

Innovation is the engine of scientific progress, yet we do not train public health students to think creatively. I present the key concepts within an evidence-based method currently taught at the University of Texas. Habitual thought patterns involve deeply held framed expectations. Finding alternatives generates originality. Because frame breaking is difficult, a series of innovation heuristics and tools are offered including enhancing observation, using analogies, changing point of view, juggling opposites, broadening perspective, reversal, reorganization and combination, and getting the most from groups. Gaining cognitive attributes such as nonjudgment, willingness to question, mindfulness, and plasticity is also emphasized. Students completing the class demonstrate substantial increases on a standardized test of idea fluency and originality, more joyful attitudes toward science, and more pluralistic approaches. PMID:25706005

[Pathophysiology of hypertension : What are our current concepts?].

PubMed

Jordan, J

2015-03-01

In the year 2015, many questions regarding the pathophysiology of essential arterial hypertension remain unresolved. Substantial scientific progress has been made in various medical areas aided by novel molecular"omics" techniques. The findings could then be implemented in diagnostic and therapeutic procedures. In the field of hypertension research such methods have been applied in very large cohorts but have contributed less to pathophysiological understanding and clinical management than expected. The findings on the pathophysiological importance of baroreflex mechanisms, natriuretic peptides and osmotically inactive sodium storage discussed in this article all have something in common: all are based on small, carefully conducted human physiological investigations and often challenge current textbook knowledge. Nevertheless, these findings have opened up new research fields and are likely to affect clinical care.

Increasing the Impact of Materials in and beyond Bio-Nano Science.

PubMed

Björnmalm, Mattias; Faria, Matthew; Caruso, Frank

2016-10-19

This is an exciting time for the field of bio-nano science: enormous progress has been made in recent years, especially in academic research, and materials developed and studied in this area are poised to make a substantial impact in real-world applications. Herein, we discuss ways to leverage the strengths of the field, current limitations, and valuable lessons learned from neighboring fields that can be adopted to accelerate scientific discovery and translational research in bio-nano science. We identify and discuss five interconnected topics: (i) the advantages of cumulative research; (ii) the necessity of aligning projects with research priorities; (iii) the value of transparent science; (iv) the opportunities presented by "dark data"; and (v) the importance of establishing bio-nano standards.

Under the sea: microbial life in volcanic oceanic crust.

PubMed

Edwards, Katrina J; Wheat, C Geoffrey; Sylvan, Jason B

2011-09-06

Exploration of the microbiology in igneous, 'hard rock' oceanic crust represents a major scientific frontier. The igneous crust harbours the largest aquifer system on Earth, most of which is hydrologically active, resulting in a substantial exchange of fluids, chemicals and microorganisms between oceanic basins and crustal reservoirs. Study of the deep-subsurface biosphere in the igneous crust is technically challenging. However, technologies have improved over the past decade, providing exciting new opportunities for the study of deep-seated marine life, including in situ and cross-disciplinary experimentation in microbiology, geochemistry and hydrogeology. In this Progress article, we describe the recent advances, available technology and remaining challenges in the study of the marine intraterrestrial microbial life that is harboured in igneous oceanic crust.

Pure science and the problem of progress.

PubMed

Douglas, Heather

2014-06-01

How should we understand scientific progress? Kuhn famously discussed science as its own internally driven venture, structured by paradigms. He also famously had a problem describing progress in science, as problem-solving ability failed to provide a clear rubric across paradigm change--paradigm changes tossed out problems as well as solving them. I argue here that much of Kuhn's inability to articulate a clear view of scientific progress stems from his focus on pure science and a neglect of applied science. I trace the history of the distinction between pure and applied science, showing how the distinction came about, the rhetorical uses to which the distinction has been put, and how pure science came to be both more valued by scientists and philosophers. I argue that the distinction between pure and applied science does not stand up to philosophical scrutiny, and that once we relinquish it, we can provide Kuhn with a clear sense of scientific progress. It is not one, though, that will ultimately prove acceptable. For that, societal evaluations of scientific work are needed.

Examining Curriculum Related Progress Using a Context-Based Test Instrument--A Comparison of Estonian Grade 10 and 11 Students

ERIC Educational Resources Information Center

Soobard, R.; Rannikmae, M.

2015-01-01

This study was undertaken to investigate the progress in operational scientific literacy skills through demonstrating cognition associated with undertaking scientific processes. Scientific literacy is taken here to mean utilising science knowledge and skills, particularly with relevance to creative problem solving and making reasoned decisions in…

Genome Resource Banking of Biomedically Important Laboratory Animals

PubMed Central

Agca, Yuksel

2014-01-01

Genome resource banking (GRB) is the systematic collection, storage, and re-distribution of biomaterials in an organized, logistical, and secure manner. Genome cyrobanks usually contain biomaterials and associated genomic information essential for progression of biomedicine, human health, and research. In that regard, appropriate genome cryobanks could provide essential biomaterials for both current and future research projects in the form of various cell types and tissues, including sperm, oocytes, embryos, embryonic or adult stem cells, induced pluripotent stem cells, and gonadal tissues. In addition to cryobanked germplasm, cryobanking of DNA, serum, blood products, and tissues from scientifically, economically and ecologically important species has become a common practice. For revitalization of the whole organism, cryopreserved germplasm in conjunction with assisted reproductive technologies (ART), offer a powerful approach for research model management, as well as assisting in animal production for agriculture, conservation, and human reproductive medicine. Recently, many developed and developing countries have allocated substantial resources to establish genome resources banks which are responsible for safeguarding scientifically, economically and ecologically important wild type, mutant and transgenic plants, fish, and local livestock breeds, as well as wildlife species. This review is dedicated to the memory of Dr. John K. Critser, who had made profound contributions to the science of cryobiology and establishment of genome research and resources centers for mice, rats and swine. Emphasis will be given to application of GRBs to species with substantial contributions to the advancement of biomedicine and human health. PMID:22981880

Use of published research in paediatric nutrition for the scientific substantiation of health claims referring to children's development and health.

PubMed

Valtueña Martínez, Silvia; Agostoni, Carlo

2013-10-01

The European Food Safety Authority (EFSA) provides policy makers with scientific and technical advice in relation to food safety and human nutrition in an independent and transparent way, and communicates such advice to the general public. Requirements for the scientific substantiation of health claims referring to children's development and health are the same as for other health claims. However, children (particularly infants) have peculiarities which should be taken into account, because these may impair the extrapolation of results to other groups. Health claims used in commercial communications should be authorized only after a scientific assessment of the highest possible standard by EFSA. EFSA's negative opinions on rejected claims should not be read as a criticism to research studies published in paediatric nutrition but rather highlight their limitations in relation to the substantiation of specific health claims made on foods. ©2013 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Adventures in data citation: sorghum genome data exemplifies the new gold standard

PubMed Central

2012-01-01

Scientific progress is driven by the availability of information, which makes it essential that data be broadly, easily and rapidly accessible to researchers in every field. In addition to being good scientific practice, provision of supporting data in a convenient way increases experimental transparency and improves research efficiency by reducing unnecessary duplication of experiments. There are, however, serious constraints that limit extensive data dissemination. One such constraint is that, despite providing a major foundation of data to the advantage of entire community, data producers rarely receive the credit they deserve for the substantial amount of time and effort they spend creating these resources. In this regard, a formal system that provides recognition for data producers would serve to incentivize them to share more of their data. The process of data citation, in which the data themselves are cited and referenced in journal articles as persistently identifiable bibliographic entities, is a potential way to properly acknowledge data output. The recent publication of several sorghum genomes in Genome Biology is a notable first example of good data citation practice in the field of genomics and demonstrates the practicalities and formatting required for doing so. It also illustrates how effective use of persistent identifiers can augment the submission of data to the current standard scientific repositories. PMID:22571506

What Determines Student Acceptance of Politically Controversial Scientific Conclusions?

ERIC Educational Resources Information Center

Walker, J. D.; Wassenberg, Deena; Franta, Gabriel; Cotner, Sehoya

2017-01-01

Certain scientific conclusions are controversial, in that they are rejected by a substantial proportion of nonscientists despite an overwhelming scientific consensus. Science educators are motivated to help students understand the evidence behind the scientific consensus on these matters and to move students' views into alignment with those held…

Why the US science and engineering workforce is aging rapidly.

PubMed

Blau, David M; Weinberg, Bruce A

2017-04-11

The science and engineering workforce has aged rapidly in recent years, both in absolute terms and relative to the workforce as a whole. This is a potential concern if the large number of older scientists crowds out younger scientists, making it difficult for them to establish independent careers. In addition, scientists are believed to be most creative earlier in their careers, so the aging of the workforce may slow the pace of scientific progress. We develop and simulate a demographic model, which shows that a substantial majority of recent aging is a result of the aging of the large baby boom cohort of scientists. However, changes in behavior have also played a significant role, in particular, a decline in the retirement rate of older scientists, induced in part by the elimination of mandatory retirement in universities in 1994. Furthermore, the age distribution of the scientific workforce is still adjusting. Current retirement rates and other determinants of employment in science imply a steady-state mean age 2.3 y higher than the 2008 level of 48.6.

Why the US science and engineering workforce is aging rapidly

PubMed Central

Blau, David M.

2017-01-01

The science and engineering workforce has aged rapidly in recent years, both in absolute terms and relative to the workforce as a whole. This is a potential concern if the large number of older scientists crowds out younger scientists, making it difficult for them to establish independent careers. In addition, scientists are believed to be most creative earlier in their careers, so the aging of the workforce may slow the pace of scientific progress. We develop and simulate a demographic model, which shows that a substantial majority of recent aging is a result of the aging of the large baby boom cohort of scientists. However, changes in behavior have also played a significant role, in particular, a decline in the retirement rate of older scientists, induced in part by the elimination of mandatory retirement in universities in 1994. Furthermore, the age distribution of the scientific workforce is still adjusting. Current retirement rates and other determinants of employment in science imply a steady-state mean age 2.3 y higher than the 2008 level of 48.6. PMID:28348239

Lessons on corporate "sustainability" disclosure from Deepwater Horizon.

PubMed

Lewis, Sanford

2011-01-01

The BP oil spill highlighted shortcomings of current financial and sustainability reporting standards and practice. "Integrated reporting" aims to combine financial and social/environmental information into a single annual corporate report. But without more stringent standards, integrated reports would neglect substantial risks and, as BP's sustainability reports demonstrate, create false impressions of good practice.To be of value, integration must: 1. Require timely disclosure of enforcement notices, orders and allegations issued by regulators. 2. Require disclosure of credible scientific reports and concerns indicative of potentially catastrophic risks of a company's products and activities, regardless of scientific uncertainty. 3. Require review and disclosures of a firm's safety culture. 4. Require disclosure of any facts or circumstances needed to ensure that the management's self-portrait of its sustainability strategies, goals and progress is not materially misleading.In conducting its misleading reporting, BP largely followed Global Reporting Initiative (GRI) guidelines. GRI is soliciting input, beginning in summer 2011, on how to revise those guidelines. Since GRI may prove a leading source for sustainability disclosure rules in integrating reporting, lessons learned from the BP experience must be applied to the next GRI revisions.

Magnetic Nanoparticles: From Design and Synthesis to Real World Applications

PubMed Central

Kudr, Jiri; Heger, Zbynek; Cernak, Mirko; Adam, Vojtech; Zitka, Ondrej

2017-01-01

The increasing number of scientific publications focusing on magnetic materials indicates growing interest in the broader scientific community. Substantial progress was made in the synthesis of magnetic materials of desired size, morphology, chemical composition, and surface chemistry. Physical and chemical stability of magnetic materials is acquired by the coating. Moreover, surface layers of polymers, silica, biomolecules, etc. can be designed to obtain affinity to target molecules. The combination of the ability to respond to the external magnetic field and the rich possibilities of coatings makes magnetic materials universal tool for magnetic separations of small molecules, biomolecules and cells. In the biomedical field, magnetic particles and magnetic composites are utilized as the drug carriers, as contrast agents for magnetic resonance imaging (MRI), and in magnetic hyperthermia. However, the multifunctional magnetic particles enabling the diagnosis and therapy at the same time are emerging. The presented review article summarizes the findings regarding the design and synthesis of magnetic materials focused on biomedical applications. We highlight the utilization of magnetic materials in separation/preconcentration of various molecules and cells, and their use in diagnosis and therapy. PMID:28850089

Establishing Long Term Data Management Research Priorities via a Data Decadal Survey

NASA Astrophysics Data System (ADS)

Wilson, A.; Uhlir, P.; Meyer, C. B.; Robinson, E.

2013-12-01

We live in a time of unprecedented collection of and access to scientific data. Improvements in sensor technologies and modeling capabilities are constantly producing new data sources. Data sets are being used for unexpected purposes far from their point of origin, as research spans projects, discipline domains, and temporal and geographic boundaries. The nature of science is evolving, with more open science, open publications, and changes to the nature of peer review and data "publication". Data-intensive, or computational science, has been identified as a new research paradigm. There is recognition that the creation of a data set can be a contribution to science deserving of recognition comparable to other scientific publications. Federally funded projects are generally expected to make their data open and accessible to everyone. In this dynamic environment, scientific progress is ever more dependent on good data management practices and policies. Yet current data management and stewardship practices are insufficient. Data sets created at great, and often public, expense are at risk of being lost for technological or organizational reasons. Insufficient documentation and understanding of data can mean that the data are used incorrectly or not at all. Scientific results are being scrutinized and questioned, and occasionally retracted due to problems in data management. The volume of data is greatly increasing while funding for data management is meager and generally must be found within existing budgets. Many federal government agencies, including NASA, USGS, NOAA and NSF are already making efforts to address data management issues. Executive memos and directives give substantial impetus to those efforts, such as the May 9 Executive Order directing agencies to implement Open Data Policy requirements and regularly report their progress. However, these distributed efforts risk duplicating effort, lack a unifying, long-term strategic vision, and too often work in competition with other priorities of the research enterprise. This presentation will introduce the Data Decadal Survey, an initial concept created in collaboration between the Federation of Earth Science Information Partners (ESIP) and of the National Research Council's Board on Research Data and Information (BRDI). Consistent with Executive open data policies, the Survey will provide a coordinating platform to address overarching issues and identify research needs and funding priorities in scientific data management and stewardship for the long term. The Survey would address at the broadest level gaps in data management knowledge and practices that hold back scientific progress, and recommend a strategy to address them. The goal is to provide a long term strategic vision that will

The end of measles and congenital rubella: an achievable dream?

PubMed

Adamo, G; Sturabotti, G; D'Andrea, E; Baccolini, V; Romano, F; Iannazzo, S; Marzuillo, C; Villari, P

2017-01-01

Despite substantial progress towards measles and rubella control, outbreaks continue to threaten elimination goals worldwide. This paper aims to document progress towards the global eradication of measles and rubella. In particular, it investigates the major challenges faced by Italy in reaching the elimination goals. A review of the most important literature was carried out. Furthermore, a systematic review of the scientific literature on measles and rubella in the Italian setting was performed for the period 2000-2016. In the National Plan 2010-2015, Italy renewed its commitment to eliminate measles and rubella by 2015. However, Italy recently experienced a high measles burden (2,205 cases in 2013, 1,694 in 2014). Between June 2015 and May 2016, 515 cases were reported, accounting for 28% all cases in Europe. Immunization coverage decreased in recent years, with no Region reaching the 95% target. The systematic review included a total of 175 papers, with an upward trend in the number of published articles, which demonstrates an increasing interest in the field of measles and rubella. The review highlights the need to improve the commitment of the Italian Regions to the elimination goals; to promote Supplementary Immunization Activities (SIAs); to improve the communication skills of health care workers; to improve the health literacy of citizens; and to enhance integrated measles and rubella surveillance. Elimination of measles and rubella in Italy will require a substantial improvement in both commitment of the 21 Regions and activity of the whole country towards the WHO goals.

Methods for structuring scientific knowledge from many areas related to aging research.

PubMed

Zhavoronkov, Alex; Cantor, Charles R

2011-01-01

Aging and age-related disease represents a substantial quantity of current natural, social and behavioral science research efforts. Presently, no centralized system exists for tracking aging research projects across numerous research disciplines. The multidisciplinary nature of this research complicates the understanding of underlying project categories, the establishment of project relations, and the development of a unified project classification scheme. We have developed a highly visual database, the International Aging Research Portfolio (IARP), available at AgingPortfolio.org to address this issue. The database integrates information on research grants, peer-reviewed publications, and issued patent applications from multiple sources. Additionally, the database uses flexible project classification mechanisms and tools for analyzing project associations and trends. This system enables scientists to search the centralized project database, to classify and categorize aging projects, and to analyze the funding aspects across multiple research disciplines. The IARP is designed to provide improved allocation and prioritization of scarce research funding, to reduce project overlap and improve scientific collaboration thereby accelerating scientific and medical progress in a rapidly growing area of research. Grant applications often precede publications and some grants do not result in publications, thus, this system provides utility to investigate an earlier and broader view on research activity in many research disciplines. This project is a first attempt to provide a centralized database system for research grants and to categorize aging research projects into multiple subcategories utilizing both advanced machine algorithms and a hierarchical environment for scientific collaboration.

Moonshot Objectives: Catalyze New Scientific Breakthroughs-Proteogenomics.

PubMed

Rodland, Karin D; Piehowski, Paul; Smith, Richard D

Breaking down the silos between disciplines to accelerate the pace of cancer research is a key paradigm for the Cancer Moonshot. Molecular analyses of cancer biology have tended to segregate between a focus on nucleic acids-DNA, RNA, and their modifications-and a focus on proteins and protein function. Proteogenomics represents a fusion of those two approaches, leveraging the strengths of each to provide a more integrated vision of the flow of information from DNA to RNA to protein and eventually function at the molecular level. Proteogenomic studies have been incorporated into multiple activities associated with the Cancer Moonshot, demonstrating substantial added value. Innovative study designs integrating genomic, transcriptomic, and proteomic data, particularly those using clinically relevant samples and involving clinical trials, are poised to provide new insights regarding cancer risk, progression, and response to therapy.

Commercialisation of Biomarker Tests for Mental Illnesses: Advances and Obstacles.

PubMed

Chan, Man K; Cooper, Jason D; Bahn, Sabine

2015-12-01

Substantial strides have been made in the field of biomarker research for mental illnesses over the past few decades. However, no US FDA-cleared blood-based biomarker tests have been translated into routine clinical practice. Here, we review the challenges associated with commercialisation of research findings and discuss how these challenges can impede scientific impact and progress. Overall evidence indicates that a lack of research funding and poor reproducibility of findings were the most important obstacles to commercialization of biomarker tests. Fraud, pre-analytical and analytical limitations, and inappropriate statistical analysis are major contributors to poor reproducibility. Increasingly, these issues are acknowledged and actions are being taken to improve data validity, raising the hope that robust biomarker tests will become available in the foreseeable future. Copyright © 2015 Elsevier Ltd. All rights reserved.

An animal tracking system for behavior analysis using radio frequency identification.

PubMed

Catarinucci, Luca; Colella, Riccardo; Mainetti, Luca; Patrono, Luigi; Pieretti, Stefano; Secco, Andrea; Sergi, Ilaria

2014-09-01

Evaluating the behavior of mice and rats has substantially contributed to the progress of research in many scientific fields. Researchers commonly observe recorded video of animal behavior and manually record their observations for later analysis, but this approach has several limitations. The authors developed an automated system for tracking and analyzing the behavior of rodents that is based on radio frequency identification (RFID) in an ultra-high-frequency bandwidth. They provide an overview of the system's hardware and software components as well as describe their technique for surgically implanting passive RFID tags in mice. Finally, the authors present the findings of two validation studies to compare the accuracy of the RFID system versus commonly used approaches for evaluating the locomotor activity and object exploration of mice.

Quarterly Progress Report (January 1 to March 31, 1950)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brookhaven National Laboratory

This is the first of a series of Quarterly Reports. These reports will deal primarily with the progress made in our scientific program during a three months period. Those interested in matters pertaining to organization, administration, complete scientific program, personnel and other matters not directly involved in current scientific progress are referred to our Annual Progress Report which is issued in January. We have attempted to describe new information that appears significant, or of interest, to other scientists within the Atomic Energy Commission Laboratories. No effort has been made, however, to detail progress in each and every research project. Littlemore » or no reference will therefore be found to the projects in which progress during the current period is considered too inconclusive. Since our organizational structure is departmental, the work described herein is arranged in the following sequence: (1) Accelerator Project; (2) Biology Department; (3) Chemistry Department; (4) Instrumentation and Health Physic8 Department; (5) Medical Department; (6) Physics Department; and (7) Reactor Science and Engineering Department.« less

Scientific and Technological Progress and Job Qualification.

ERIC Educational Resources Information Center

Ivanov, N. P.

Clarifying the influences determining how and to what extent highly qualified personnel are employed, this study discusses those sorts of economic and technological advances affecting employment potentials. Two main trends in scientific and technological progress--computerized industries and the high science-content of production--have so…

24 CFR 598.430 - Revocation of designation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... approval from HUD; (2) Has failed to make progress in implementing the strategic plan; or (3) Has not complied substantially with the strategic plan. (b) Letter of warning. Before revoking the designation of... complying substantially with, or has failed to make progress in implementing the strategic plan; and (2...

24 CFR 598.430 - Revocation of designation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... approval from HUD; (2) Has failed to make progress in implementing the strategic plan; or (3) Has not complied substantially with the strategic plan. (b) Letter of warning. Before revoking the designation of... complying substantially with, or has failed to make progress in implementing the strategic plan; and (2...

The Inadmissibility of What We Eat in America and NHANES Dietary Data in Nutrition and Obesity Research and the Scientific Formulation of National Dietary Guidelines.

PubMed

Archer, Edward; Pavela, Gregory; Lavie, Carl J

2015-07-01

The Scientific Report of the 2015 Dietary Guidelines Advisory Committee was primarily informed by memory-based dietary assessment methods (M-BMs) (eg, interviews and surveys). The reliance on M-BMs to inform dietary policy continues despite decades of unequivocal evidence that M-BM data bear little relation to actual energy and nutrient consumption. Data from M-BMs are defended as valid and valuable despite no empirical support and no examination of the foundational assumptions regarding the validity of human memory and retrospective recall in dietary assessment. We assert that uncritical faith in the validity and value of M-BMs has wasted substantial resources and constitutes the greatest impediment to scientific progress in obesity and nutrition research. Herein, we present evidence that M-BMs are fundamentally and fatally flawed owing to well-established scientific facts and analytic truths. First, the assumption that human memory can provide accurate or precise reproductions of past ingestive behavior is indisputably false. Second, M-BMs require participants to submit to protocols that mimic procedures known to induce false recall. Third, the subjective (ie, not publicly accessible) mental phenomena (ie, memories) from which M-BM data are derived cannot be independently observed, quantified, or falsified; as such, these data are pseudoscientific and inadmissible in scientific research. Fourth, the failure to objectively measure physical activity in analyses renders inferences regarding diet-health relationships equivocal. Given the overwhelming evidence in support of our position, we conclude that M-BM data cannot be used to inform national dietary guidelines and that the continued funding of M-BMs constitutes an unscientific and major misuse of research resources. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Hyphenated hydrology: Interdisciplinary evolution of water resource science

NASA Astrophysics Data System (ADS)

McCurley, Kathryn L.; Jawitz, James W.

2017-04-01

Hydrology has advanced considerably as a scientific discipline since its recognized inception in the mid-twentieth century. Modern water resource related questions have forced adaptation from exclusively physical or engineering science viewpoints toward a deliberate interdisciplinary context. Over the past few decades, many of the eventual manifestations of this evolution were foreseen by prominent expert hydrologists. However, their narrative descriptions have lacked substantial quantification. This study addressed that gap by measuring the prevalence of and analyzing the relationships between the terms most frequently used by hydrologists to define and describe their research. We analyzed 16,591 journal article titles from 1965-2015 in Water Resources Research, through which the scientific dialogue and its time-sensitive progression emerged. Our word frequency and term cooccurrence network results revealed the dynamic timing of the lateral movement of hydrology across multiple disciplines as well as the deepening of scientific discourse with respect to traditional hydrologic questions. The conversation among water resource scientists surrounding the hydrologic subdisciplines of catchment-hydrology, hydro-meteorology, socio-hydrology, hydro-climatology, and eco-hydrology gained statistically significant momentum in the analyzed time period, while that of hydro-geology and contaminant-hydrology experienced periods of increase followed by significant decline. This study concludes that formerly exotic disciplines can potentially modify hydrology, prompting new insights and inspiring unconventional perspectives on old questions that may have otherwise become obsolete.

Progress and challenges in TB vaccine development

PubMed Central

Voss, Gerald; Casimiro, Danilo; Neyrolles, Olivier; Williams, Ann; Kaufmann, Stefan H.E.; McShane, Helen; Hatherill, Mark; Fletcher, Helen A

2018-01-01

The Bacille Calmette Guerin (BCG) vaccine can provide decades of protection against tuberculosis (TB) disease, and although imperfect, BCG is proof that vaccine mediated protection against TB is a possibility. A new TB vaccine is, therefore, an inevitability; the question is how long will it take us to get there? We have made substantial progress in the development of vaccine platforms, in the identification of antigens and of immune correlates of risk of TB disease. We have also standardized animal models to enable head-to-head comparison and selection of candidate TB vaccines for further development.  To extend our understanding of the safety and immunogenicity of TB vaccines we have performed experimental medicine studies to explore route of administration and have begun to develop controlled human infection models. Driven by a desire to reduce the length and cost of human efficacy trials we have applied novel approaches to later stage clinical development, exploring alternative clinical endpoints to prevention of disease outcomes. Here, global leaders in TB vaccine development discuss the progress made and the challenges that remain. What emerges is that, despite scientific progress, few vaccine candidates have entered clinical trials in the last 5 years and few vaccines in clinical trials have progressed to efficacy trials. Crucially, we have undervalued the knowledge gained from our “failed” trials and fostered a culture of risk aversion that has limited new funding for clinical TB vaccine development. The unintended consequence of this abundance of caution is lack of diversity of new TB vaccine candidates and stagnation of the clinical pipeline. We have a variety of new vaccine platform technologies, mycobacterial antigens and animal and human models.  However, we will not encourage progression of vaccine candidates into clinical trials unless we evaluate and embrace risk in pursuit of vaccine development. PMID:29568497

Progress and challenges in TB vaccine development.

PubMed

Voss, Gerald; Casimiro, Danilo; Neyrolles, Olivier; Williams, Ann; Kaufmann, Stefan H E; McShane, Helen; Hatherill, Mark; Fletcher, Helen A

2018-01-01

The Bacille Calmette Guerin (BCG) vaccine can provide decades of protection against tuberculosis (TB) disease, and although imperfect, BCG is proof that vaccine mediated protection against TB is a possibility. A new TB vaccine is, therefore, an inevitability; the question is how long will it take us to get there? We have made substantial progress in the development of vaccine platforms, in the identification of antigens and of immune correlates of risk of TB disease. We have also standardized animal models to enable head-to-head comparison and selection of candidate TB vaccines for further development.  To extend our understanding of the safety and immunogenicity of TB vaccines we have performed experimental medicine studies to explore route of administration and have begun to develop controlled human infection models. Driven by a desire to reduce the length and cost of human efficacy trials we have applied novel approaches to later stage clinical development, exploring alternative clinical endpoints to prevention of disease outcomes. Here, global leaders in TB vaccine development discuss the progress made and the challenges that remain. What emerges is that, despite scientific progress, few vaccine candidates have entered clinical trials in the last 5 years and few vaccines in clinical trials have progressed to efficacy trials. Crucially, we have undervalued the knowledge gained from our "failed" trials and fostered a culture of risk aversion that has limited new funding for clinical TB vaccine development. The unintended consequence of this abundance of caution is lack of diversity of new TB vaccine candidates and stagnation of the clinical pipeline. We have a variety of new vaccine platform technologies, mycobacterial antigens and animal and human models.  However, we will not encourage progression of vaccine candidates into clinical trials unless we evaluate and embrace risk in pursuit of vaccine development.

Building Scientific Confidence in Read-Across: Progress in using HT Data to inform Read-Across Performance (Toxicology Forum)

EPA Science Inventory

Presentation at the 41st Annual Winter Meeting of The Toxicology Forum - From Assay to Assessment: Incorporating High Throughput Strategies into Health and Safety Evaluations on Building Scientific Confidence in Read-Across: Progress in using HT Data to inform Read-Across Perfor...

The right to enjoy the benefits of scientific progress: in search of state obligations in relation to health.

PubMed

Donders, Yvonne

2011-11-01

After having received little attention over the past decades, one of the least known human rights--the right to enjoy the benefits of scientific progress and its applications--has had its dust blown off. Although included in the Universal Declaration of Human Rights (UDHR) and in the International Covenant on Economic, Social and Cultural Rights (ICESCR)--be it at the very end of both instruments -this right hardly received any attention from States, UN bodies and programmes and academics. The role of science in societies and its benefits and potential danger were discussed in various international fora, but hardly ever in a human rights context. Nowadays, within a world that is increasingly turning to science and technology for solutions to persistent socio-economic and development problems, the human dimension of science also receives increased attention, including the human right to enjoy the benefits of scientific progress and its applications. This contribution analyses the possible legal obligations of States in relation to the right to enjoy the benefits of scientific progress and its applications, in particular as regards health.

[The supervisor has a crucial role in the medical student's degree projects. Experiences from seven semesters at Karolinska Institutet].

PubMed

Möller, Riitta; Shoshan, Maria; Ponzer, Sari

2015-01-13

In Sweden degree projects have a central role in evaluation of higher education, wherefore significant resources are spent on developing students' research competence. The undergraduate medical program at Karolinska Institutet introduced its degree project course in 2010. This paper gives an overview of the course and summarizes experiences from the first seven terms. In order to finalize their projects within one term, most students need substantial support. A highly structured course and frequent progress monitoring are advantageous. Other crucial factors are the quality of the supervision and students' verbal skills as well as support in scientific writing. In addition, increased awareness of the learning outcomes already at the beginning of the course may help students to achieve the expected results. Finally, students need to recognize their own responsibility for learning. 

The future of pharmaceutical manufacturing in the context of the scientific, social, technological and economic evolution.

PubMed

Stegemann, Sven

2016-07-30

Healthcare provision is one of the import elements of modern societies. Life sciences and technology has made substantial progress over the past century and is continuing to evolve exponentially in many different areas. The use of genotypic and phenotypic information in drug discovery and drug therapy, the increasing wealth around the world, growing patient involvement through information and communication technology and finally innovations in pharmaceutical manufacturing technology are transforming the provision of healthcare. The adoption of this new science and technology is going to happen due to the synergistic effects and visible benefits for the society and healthcare systems. The different aspects driving advanced pharmaceutical manufacturing are reviewed to identify future research direction to assure overall acceptance and adoption into healthcare practice. Copyright © 2015 Elsevier B.V. All rights reserved.

Emerging infections: a perpetual challenge

PubMed Central

Morens, David M; Folkers, Gregory K; Fauci, Anthony S

2008-01-01

Emerging and re-emerging infectious diseases, and their determinants, have recently attracted substantial scientific and popular attention. HIV/AIDS, severe acute respiratory syndrome, H5N1 avian influenza, and many other emerging diseases have either proved fatal or caused international alarm. Common and interactive co-determinants of disease emergence, including population growth, travel, and environmental disruption, have been increasingly documented and studied. Are emerging infections a new phenomenon related to modern life, or do more basic determinants, transcending time, place, and human progress, govern disease generation? By examining a number of historically notable epidemics, we suggest that emerging diseases, similar in their novelty, impact, and elicitation of control responses, have occurred throughout recorded history. Fundamental determinants, typically acting in concert, seem to underlie their emergence, and infections such as these are likely to continue to remain challenges to human survival. PMID:18992407

Preface of the special issue: "Vertical coupling in the atmosphere-ionosphere system: Recent progress"

NASA Astrophysics Data System (ADS)

2018-06-01

This special issue of the Journal of Atmospheric and Solar-Terrestrial Physics comprises papers dealing with investigation of the coupling phenomena in the neutral Atmosphere-Ionosphere System of the Earth. The core of the special issue is formed by the recent results presented during the 6th IAGA/ICMA/SCOSTEP Workshop on the Vertical Coupling in the Neutral Atmosphere-Ionosphere System held in Taipei, Taiwan, July 2016. Workshops are organized with a substantial support of the scientific international bodies, such as the International Association of Geomagnetism and Aeronomy (IAGA), International Commission for the Middle Atmosphere (ICMA) and Committee on Solar-Terrestrial Physics (SCOSTEP). The special issue includes also recent results of other members of the aeronomic research community. Hence it represents the state-of-art knowledge in the associated research fields.

The Agricultural Model Intercomparison and Improvement Project (AgMIP): Progress and Preliminary Results

NASA Astrophysics Data System (ADS)

Rosenzweig, C.

2011-12-01

The Agricultural Model Intercomparison and Improvement Project (AgMIP) is a distributed climate-scenario simulation exercise for historical model intercomparison and future climate change conditions with participation of multiple crop and agricultural trade modeling groups around the world. The goals of AgMIP are to improve substantially the characterization of risk of hunger and world food security due to climate change and to enhance adaptation capacity in both developing and developed countries. Recent progress and the current status of AgMIP will be presented, highlighting three areas of activity: preliminary results from crop pilot studies, outcomes from regional workshops, and emerging scientific challenges. AgMIP crop modeling efforts are being led by pilot studies, which have been established for wheat, maize, rice, and sugarcane. These crop-specific initiatives have proven instrumental in testing and contributing to AgMIP protocols, as well as creating preliminary results for aggregation and input to agricultural trade models. Regional workshops are being held to encourage collaborations and set research activities in motion for key agricultural areas. The first of these workshops was hosted by Embrapa and UNICAMP and held in Campinas, Brazil. Outcomes from this meeting have informed crop modeling research activities within South America, AgMIP protocols, and future regional workshops. Several scientific challenges have emerged and are currently being addressed by AgMIP researchers. Areas of particular interest include geospatial weather generation, ensemble methods for climate scenarios and crop models, spatial aggregation of field-scale yields to regional and global production, and characterization of future changes in climate variability.

Dredging in a changing scientific and regulatory environment

DOT National Transportation Integrated Search

2004-06-01

Dredging activities associated with commercial navigation have been the subject of substantial public policy conflict. At both the national and local levels, substantial concern has been expressed over the environmental consequences of the disposal o...

Foundation stones for a real socio-environmental integration in projects' impact assessments

NASA Astrophysics Data System (ADS)

Andres Dominguez-Gomez, J.

2015-04-01

In the last twenty years, both the increase in academic production and the expansion of professional involvement in Environmental Impact Assessment (EIA) and Social Impact Assessment (SIA), have evidenced growing scientific and business interest in risk and impact analysis. However, this growth has not brought with it a parallel progress in addressing their main shortcomings: insufficient integration of environmental and social features into development project analyses and, in cases where the social aspects are considered, technical-methodological failings in their diagnosis and assessment. It is clear that these weaknesses carry with them substantial threats to the sustainability (social, environmental and economic) of schemes which impact on the environment, and in consequence, to the local contexts where they are carried out and to the delicate balance of the global ecosystem. This paper argue that, in a sociological context of growing complexity, four foundation-stones are required to underpin research methodologies (for both diagnosis and assessment) in the socio-environmental risks of development projects: a theoretical foundation in actor-network theory; an ethical grounding in values which are internationally recognized though not always carried through into practice; a (new) epistemological-scientific base; and a methodological foundation in social participation.

WWW: The Scientific Method

ERIC Educational Resources Information Center

Blystone, Robert V.; Blodgett, Kevin

2006-01-01

The scientific method is the principal methodology by which biological knowledge is gained and disseminated. As fundamental as the scientific method may be, its historical development is poorly understood, its definition is variable, and its deployment is uneven. Scientific progress may occur without the strictures imposed by the formal…

Sex Differences in Mathematics and Science Achievement: A Meta-Analysis of National Assessment of Educational Progress Assessments

ERIC Educational Resources Information Center

Reilly, David; Neumann, David L.; Andrews, Glenda

2015-01-01

Gender gaps in the development of mathematical and scientific literacy have important implications for the general public's understanding of scientific issues and for the underrepresentation of women in science, technology, engineering, and math. We subjected data from the National Assessment of Educational Progress to a meta-analysis to examine…

A Learning Progression for Scientific Argumentation: Understanding Student Work and Designing Supportive Instructional Contexts

ERIC Educational Resources Information Center

Berland, Leema K.; McNeill, Katherine L.

2010-01-01

Argumentation is a central goal of science education because it engages students in a complex scientific practice in which they construct and justify knowledge claims. Although there is a growing body of research around argumentation, there has been little focus on developing a learning progression for this practice. We describe a learning…

ANNUAL REPORT, JULY 1, 1958

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1959-02-01

This annual report of Brookhaven National Laboratory describes its program and activities for the fiscal year 1958. The progress and trends of the research program are presented along with a description of the operational, service, and administrative activities of the Laboratory. The scientific and technical details of the many research and development activities are covered more fully in scientific and technical periodicals and in the quarterly scientific progress reports and other scientiflc reports of the Laboratory. A list of all publications for July 1, 1957 to June 30, 1958, is given. Status and progress are given in fields of physics,more » accelerator development, instrumentation, applied mathematics, chemistry, nuclear engineering, biology, and medical research. (For preceding period see BNL-462.) (W.D.M.)« less

Lightweight and Statistical Techniques for Petascale Debugging: Correctness on Petascale Systems (CoPS) Preliminry Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

de Supinski, B R; Miller, B P; Liblit, B

2011-09-13

Petascale platforms with O(10{sup 5}) and O(10{sup 6}) processing cores are driving advancements in a wide range of scientific disciplines. These large systems create unprecedented application development challenges. Scalable correctness tools are critical to shorten the time-to-solution on these systems. Currently, many DOE application developers use primitive manual debugging based on printf or traditional debuggers such as TotalView or DDT. This paradigm breaks down beyond a few thousand cores, yet bugs often arise above that scale. Programmers must reproduce problems in smaller runs to analyze them with traditional tools, or else perform repeated runs at scale using only primitive techniques.more » Even when traditional tools run at scale, the approach wastes substantial effort and computation cycles. Continued scientific progress demands new paradigms for debugging large-scale applications. The Correctness on Petascale Systems (CoPS) project is developing a revolutionary debugging scheme that will reduce the debugging problem to a scale that human developers can comprehend. The scheme can provide precise diagnoses of the root causes of failure, including suggestions of the location and the type of errors down to the level of code regions or even a single execution point. Our fundamentally new strategy combines and expands three relatively new complementary debugging approaches. The Stack Trace Analysis Tool (STAT), a 2011 R&D 100 Award Winner, identifies behavior equivalence classes in MPI jobs and highlights behavior when elements of the class demonstrate divergent behavior, often the first indicator of an error. The Cooperative Bug Isolation (CBI) project has developed statistical techniques for isolating programming errors in widely deployed code that we will adapt to large-scale parallel applications. Finally, we are developing a new approach to parallelizing expensive correctness analyses, such as analysis of memory usage in the Memgrind tool. In the first two years of the project, we have successfully extended STAT to determine the relative progress of different MPI processes. We have shown that the STAT, which is now included in the debugging tools distributed by Cray with their large-scale systems, substantially reduces the scale at which traditional debugging techniques are applied. We have extended CBI to large-scale systems and developed new compiler based analyses that reduce its instrumentation overhead. Our results demonstrate that CBI can identify the source of errors in large-scale applications. Finally, we have developed MPIecho, a new technique that will reduce the time required to perform key correctness analyses, such as the detection of writes to unallocated memory. Overall, our research results are the foundations for new debugging paradigms that will improve application scientist productivity by reducing the time to determine which package or module contains the root cause of a problem that arises at all scales of our high end systems. While we have made substantial progress in the first two years of CoPS research, significant work remains. While STAT provides scalable debugging assistance for incorrect application runs, we could apply its techniques to assertions in order to observe deviations from expected behavior. Further, we must continue to refine STAT's techniques to represent behavioral equivalence classes efficiently as we expect systems with millions of threads in the next year. We are exploring new CBI techniques that can assess the likelihood that execution deviations from past behavior are the source of erroneous execution. Finally, we must develop usable correctness analyses that apply the MPIecho parallelization strategy in order to locate coding errors. We expect to make substantial progress on these directions in the next year but anticipate that significant work will remain to provide usable, scalable debugging paradigms.« less

29 CFR 1926.60 - Methylenedianiline.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the following: (i) Construction, alteration, repair, maintenance, or renovation of structures... based are scientifically sound and were collected using methods that are sufficiently accurate and... are substantially similar. The data must be scientifically sound, the characteristics of the MDA...

29 CFR 1926.60 - Methylenedianiline.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the following: (i) Construction, alteration, repair, maintenance, or renovation of structures... based are scientifically sound and were collected using methods that are sufficiently accurate and... are substantially similar. The data must be scientifically sound, the characteristics of the MDA...

29 CFR 1926.60 - Methylenedianiline.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the following: (i) Construction, alteration, repair, maintenance, or renovation of structures... based are scientifically sound and were collected using methods that are sufficiently accurate and... are substantially similar. The data must be scientifically sound, the characteristics of the MDA...

Creationism and intelligent design are incompatible with scientific progress: A response to Shanta and Vêdanta.

PubMed

Caetano-Anollés, Gustavo

2016-01-01

In a recent opinion paper, B.K. Shanta claims science leaves no room for the subjective aspect of consciousness, and in doing so, attacks both origin of life and evolutionary research. He claims Vêdanta, one of the 6 orthodox schools of Hindu philosophy, offers an explanation: "the origin of everything material and nonmaterial is sentient and absolute." Here I discuss how the pseudoscience of these creationist views, which are aligned with Intelligent Design, are incompatible with scientific progress and should not be published in scientific journals.

[Scientific reductionism and social control of mind. Part II].

PubMed

Viniegra Velázquez, Leonardo

In the second part of this essay, the progressive subordination of scientific endeavor and knowledge of business and profit is pointed out. For instance, the way facts are prioritized over concepts and ideas in scientific knowledge can translate into technological innovation, central to enterprise competitiveness and key to social mechanisms of control (military, cybernetic, ideological). Overcoming the scientific reductionism approach indicates recognizing the need to define progress in another way, one that infuses scientific knowledge with real liberating and inquisitive power. Power is essential in the search for a more collaborative, inclusive and pluralistic society where respect for human dignity and care for the ecosystem that we live in are prioritized. Copyright © 2014 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

The ecosystem approach to fisheries: management at the dynamic interface between biodiversity conservation and sustainable use.

PubMed

Jennings, Simon; Smith, Anthony D M; Fulton, Elizabeth A; Smith, David C

2014-08-01

The emergence of an ecosystem approach to fisheries (EAF) was characterized by the adoption of objectives for maintaining ecosystem health alongside those for fisheries. The EAF was expected to meet some aspirations for biodiversity conservation, but health was principally linked to sustainable use rather than lower levels of human impact. Consequently, while policies including EAF concepts identified objectives for fisheries management and biodiversity conservation, the wording often reflected unresolved societal and political debates about objectives and gave imprecise guidance on addressing inevitable trade-offs. Despite scientific progress in making trade-offs and consequences explicit, there remain substantial differences in interpretations of acceptable impact, responses to uncertainty and risk, and the use of management measures by groups accountable for fisheries management and biodiversity conservation. Within and among nations and regions, these differences are influenced by the contribution of fisheries, aquaculture, farming, and trade to food security, consumers' options, and other social, economic, and environmental factors. Notwithstanding, mutual understanding of the motivations and norms of fisheries management and biodiversity conservation groups is increasing, and interactions between these groups have likely supported more progress toward meeting their stated objectives than would have otherwise been achievable. © 2014 New York Academy of Sciences.

Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm

PubMed Central

Seto, Sai Wang; Chang, Dennis; Kiat, Hosen; Wang, Ning; Bensoussan, Alan

2018-01-01

Abdominal aortic aneurysm (AAA) is an irreversible condition where the abdominal aorta is dilated leading to potentially fatal consequence of aortic rupture. Multiple mechanisms are involved in the development and progression of AAA, including chronic inflammation, oxidative stress, vascular smooth muscle (VSMC) apoptosis, immune cell infiltration and extracellular matrix (ECM) degradation. Currently surgical therapies, including minimally invasive endovascular aneurysm repair (EVAR), are the only viable interventions for AAAs. However, these treatments are not appropriate for the majority of AAAs, which measure <50 mm. Substantial effort has been invested to identify and develop pharmaceutical treatments such as statins and doxycycline for this potentially lethal condition but these interventions failed to offer a cure or to retard the progression of AAA. Chinese herbal medicine (CHM) has been used for the management of cardiovascular diseases for thousands of years in China and other Asian countries. The unique multi-component and multi-target property of CHMs makes it a potentially ideal therapy for multifactorial diseases such as AAA. In this review, we review the current scientific evidence to support the use of CHMs for the treatment of AAA. Mechanisms of action underlying the effects of CHMs on AAA are also discussed. PMID:29732374

Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm.

PubMed

Seto, Sai Wang; Chang, Dennis; Kiat, Hosen; Wang, Ning; Bensoussan, Alan

2018-01-01

Abdominal aortic aneurysm (AAA) is an irreversible condition where the abdominal aorta is dilated leading to potentially fatal consequence of aortic rupture. Multiple mechanisms are involved in the development and progression of AAA, including chronic inflammation, oxidative stress, vascular smooth muscle (VSMC) apoptosis, immune cell infiltration and extracellular matrix (ECM) degradation. Currently surgical therapies, including minimally invasive endovascular aneurysm repair (EVAR), are the only viable interventions for AAAs. However, these treatments are not appropriate for the majority of AAAs, which measure <50 mm. Substantial effort has been invested to identify and develop pharmaceutical treatments such as statins and doxycycline for this potentially lethal condition but these interventions failed to offer a cure or to retard the progression of AAA. Chinese herbal medicine (CHM) has been used for the management of cardiovascular diseases for thousands of years in China and other Asian countries. The unique multi-component and multi-target property of CHMs makes it a potentially ideal therapy for multifactorial diseases such as AAA. In this review, we review the current scientific evidence to support the use of CHMs for the treatment of AAA. Mechanisms of action underlying the effects of CHMs on AAA are also discussed.

Vaccine-induced T cells Provide Partial Protection Against High-dose Rectal SIVmac239 Challenge of Rhesus Macaques

PubMed Central

Lasaro, Marcio O; Haut, Larissa H; Zhou, Xiangyang; Xiang, Zhiquan; Zhou, Dongming; Li, Yan; Giles-Davis, Wynetta; Li, Hua; Engram, Jessica C; DiMenna, Lauren J; Bian, Ang; Sazanovich, Marina; Parzych, Elizabeth M; Kurupati, Raj; Small, Juliana C; Wu, Te-Lang; Leskowitz, Rachel M; Klatt, Nicole R; Brenchley, Jason M; Garber, David A; Lewis, Mark; Ratcliffe, Sarah J; Betts, Michael R; Silvestri, Guido; Ertl, Hildegund C

2011-01-01

Despite enormous efforts by the scientific community, an effective HIV vaccine remains elusive. To further address to what degree T cells in absence of antibodies may protect against simian immunodeficiency virus (SIV) disease progression, rhesus macaques were vaccinated intramuscularly with a chimpanzee-derived Ad vector (AdC) serotype 6 and then boosted intramuscularly with a serologically distinct AdC vector of serotype 7 both expressing Gag of SIVmac239. Animals were subsequently boosted intramuscularly with a modified vaccinia Ankara (MVA) virus expressing Gag and Tat of the homologous SIV before mucosal challenge with a high dose of SIVmac239 given rectally. Whereas vaccinated animals showed only a modest reduction of viral loads, their overall survival was improved, in association with a substantial protection from the loss of CD4+ T cells. In addition, the two vaccinated Mamu-A*01+ macaques controlled viral loads to levels below detection within weeks after challenge. These data strongly suggest that T cells, while unable to affect SIV acquisition upon high-dose rectal infection, can reduce disease progression. Induction of potent T-cell responses should thus remain a component of our efforts to develop an efficacious vaccine to HIV-1. PMID:21081905

Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques.

PubMed

Lasaro, Marcio O; Haut, Larissa H; Zhou, Xiangyang; Xiang, Zhiquan; Zhou, Dongming; Li, Yan; Giles-Davis, Wynetta; Li, Hua; Engram, Jessica C; Dimenna, Lauren J; Bian, Ang; Sazanovich, Marina; Parzych, Elizabeth M; Kurupati, Raj; Small, Juliana C; Wu, Te-Lang; Leskowitz, Rachel M; Klatt, Nicole R; Brenchley, Jason M; Garber, David A; Lewis, Mark; Ratcliffe, Sarah J; Betts, Michael R; Silvestri, Guido; Ertl, Hildegund C

2011-02-01

Despite enormous efforts by the scientific community, an effective HIV vaccine remains elusive. To further address to what degree T cells in absence of antibodies may protect against simian immunodeficiency virus (SIV) disease progression, rhesus macaques were vaccinated intramuscularly with a chimpanzee-derived Ad vector (AdC) serotype 6 and then boosted intramuscularly with a serologically distinct AdC vector of serotype 7 both expressing Gag of SIVmac239. Animals were subsequently boosted intramuscularly with a modified vaccinia Ankara (MVA) virus expressing Gag and Tat of the homologous SIV before mucosal challenge with a high dose of SIVmac239 given rectally. Whereas vaccinated animals showed only a modest reduction of viral loads, their overall survival was improved, in association with a substantial protection from the loss of CD4(+) T cells. In addition, the two vaccinated Mamu-A*01(+) macaques controlled viral loads to levels below detection within weeks after challenge. These data strongly suggest that T cells, while unable to affect SIV acquisition upon high-dose rectal infection, can reduce disease progression. Induction of potent T-cell responses should thus remain a component of our efforts to develop an efficacious vaccine to HIV-1.

Validity Evidence for a Learning Progression of Scientific Explanation

ERIC Educational Resources Information Center

Yao, Jian-Xin; Guo, Yu-Ying

2018-01-01

Providing scientific explanations for natural phenomena is a fundamental aim of science; therefore, scientific explanation has been selected as one of the key practices in science education policy documents around the world. To further elaborate on existing educational frameworks of scientific explanation in K-12, we propose a learning progression…

Flaws in the LNT single-hit model for cancer risk: An historical assessment.

PubMed

Calabrese, Edward J

2017-10-01

The LNT single-hit model was derived from the Nobel Prize-winning research of Herman J. Muller who showed that x-rays could induce gene mutations in Drosophila and that the dose response for these so-called mutational events was linear. Lewis J. Stadler, another well-known and respected geneticist at the time, strongly disagreed with and challenged Muller's claims. Detailed evaluations by Stadler over a prolonged series of investigations revealed that Muller's experiments had induced gross heritable chromosomal damage instead of specific gene mutations as had been claimed by Muller at his Nobel Lecture. These X-ray-induced alterations became progressively more frequent and were of larger magnitude (more destructive) with increasing doses. Thus, Muller's claim of having induced discrete gene mutations represented a substantial speculative overreach and was, in fact, without proof. The post hoc arguments of Muller to support his gene mutation hypothesis were significantly challenged and weakened by a series of new findings in the areas of cytogenetics, reverse mutation, adaptive and repair processes, and modern molecular methods for estimating induced genetic damage. These findings represented critical and substantial limitations to Muller's hypothesis of X-ray-induced gene mutations. Furthermore, they challenged the scientific foundations used in support of the LNT single-hit model by severing the logical nexus between Muller's data on radiation-induced inheritable alterations and the LNT single-hit model. These findings exposed fundamental scientific flaws that undermined not only the seminal recommendation of the 1956 BEAR I Genetics Panel to adopt the LNT single-hit Model for risk assessment but also any rationale for its continued use in the present day. Copyright © 2017 Elsevier Inc. All rights reserved.

Economics and public value of urban forests

Treesearch

Kathleen L. Wolf

2004-01-01

Scientific understanding of how urban trees, forests and green space benefit people has expanded substantially in recent years to include social, environmental and economic domains. Despite increasing scientific evidence, there is a lag in policy response in many municipalities.

Is Science Logical?

ERIC Educational Resources Information Center

Pease, Craig M.; Bull, J. J.

1992-01-01

Offers a concise, abstract description of the scientific method different from the historical, philosophical, and case-study approaches, which lead to comprehension of this method. Discusses features of scientific models, dynamic interactions underlying scientific progress, ways that scientist successfully understand nature, mechanisms for…

Promoting professional identity, motivation, and persistence: Benefits of an informal mentoring program for female undergraduate students

PubMed Central

Bloodhart, Brittany; Barnes, Rebecca T.; Adams, Amanda S.; Clinton, Sandra M.; Pollack, Ilana; Godfrey, Elaine; Burt, Melissa; Fischer, Emily V.

2017-01-01

Women are underrepresented in a number of science, technology, engineering, and mathematics (STEM) disciplines. Limited diversity in the development of the STEM workforce has negative implications for scientific innovation, creativity, and social relevance. The current study reports the first-year results of the PROmoting Geoscience Research, Education, and SuccesS (PROGRESS) program, a novel theory-driven informal mentoring program aimed at supporting first- and second-year female STEM majors. Using a prospective, longitudinal, multi-site (i.e., 7 universities in Colorado/Wyoming Front Range & Carolinas), propensity score matched design, we compare mentoring and persistence outcomes for women in and out of PROGRESS (N = 116). Women in PROGRESS attended an off-site weekend workshop and gained access to a network of volunteer female scientific mentors from on- and off-campus (i.e., university faculty, graduate students, and outside scientific professionals). The results indicate that women in PROGRESS had larger networks of developmental mentoring relationships and were more likely to be mentored by faculty members and peers than matched controls. Mentoring support from a faculty member benefited early-undergraduate women by strengthening their scientific identity and their interest in earth and environmental science career pathways. Further, support from a faculty mentor had a positive indirect impact on women’s scientific persistence intentions, through strengthened scientific identity development. These results imply that first- and second- year undergraduate women’s mentoring support networks can be enhanced through provision of protégé training and access to more senior women in the sciences willing to provide mentoring support. PMID:29091969

Promoting professional identity, motivation, and persistence: Benefits of an informal mentoring program for female undergraduate students.

PubMed

Hernandez, Paul R; Bloodhart, Brittany; Barnes, Rebecca T; Adams, Amanda S; Clinton, Sandra M; Pollack, Ilana; Godfrey, Elaine; Burt, Melissa; Fischer, Emily V

2017-01-01

Women are underrepresented in a number of science, technology, engineering, and mathematics (STEM) disciplines. Limited diversity in the development of the STEM workforce has negative implications for scientific innovation, creativity, and social relevance. The current study reports the first-year results of the PROmoting Geoscience Research, Education, and SuccesS (PROGRESS) program, a novel theory-driven informal mentoring program aimed at supporting first- and second-year female STEM majors. Using a prospective, longitudinal, multi-site (i.e., 7 universities in Colorado/Wyoming Front Range & Carolinas), propensity score matched design, we compare mentoring and persistence outcomes for women in and out of PROGRESS (N = 116). Women in PROGRESS attended an off-site weekend workshop and gained access to a network of volunteer female scientific mentors from on- and off-campus (i.e., university faculty, graduate students, and outside scientific professionals). The results indicate that women in PROGRESS had larger networks of developmental mentoring relationships and were more likely to be mentored by faculty members and peers than matched controls. Mentoring support from a faculty member benefited early-undergraduate women by strengthening their scientific identity and their interest in earth and environmental science career pathways. Further, support from a faculty mentor had a positive indirect impact on women's scientific persistence intentions, through strengthened scientific identity development. These results imply that first- and second- year undergraduate women's mentoring support networks can be enhanced through provision of protégé training and access to more senior women in the sciences willing to provide mentoring support.

Four conceptual issues to consider in integrating social and environmental factors in risk and impact assessments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Domínguez-Gómez, J. Andrés, E-mail: andres@uhu.es

In the last twenty years, both the increase in academic production and the expansion of professional involvement in Environmental Impact Assessment (EIA) and Social Impact Assessment (SIA) have evidenced growing scientific and business interest in risk and impact analysis. However, this growth has not brought with it parallel progress in addressing the main shortcomings of EIA/SIA, i.e. insufficient integration of environmental and social factors into development project analyses and, in cases where the social aspects are considered, technical-methodological failings in their analysis and assessment. It is clear that these weaknesses carry with them substantial threats to the sustainability (social, environmentalmore » and economic) of projects which impact on the environment, and consequently to the local contexts where they are carried out and to the delicate balance of the global ecosystem. This paper argues that, in a sociological context of complexity and dynamism, four conceptual elements should underpin approaches to socio-environmental risk and impact assessment in development projects: a theoretical base in actor–network theory; an ethical grounding in values which are internationally recognized (though not always fulfilled in practice); a (new) epistemological-scientific base; and a methodological foundation in social participation. - Highlights: • A theoretical foundation in actor–network theory • An ethical grounding in values which are internationally recognized, but rarely carried through into practice • A (new) epistemological-scientific base • A methodological foundation in social participation.« less

Rugged and breathable forms of stretchable electronics with adherent composite substrates for transcutaneous monitoring.

PubMed

Jang, Kyung-In; Han, Sang Youn; Xu, Sheng; Mathewson, Kyle E; Zhang, Yihui; Jeong, Jae-Woong; Kim, Gwang-Tae; Webb, R Chad; Lee, Jung Woo; Dawidczyk, Thomas J; Kim, Rak Hwan; Song, Young Min; Yeo, Woon-Hong; Kim, Stanley; Cheng, Huanyu; Rhee, Sang Il; Chung, Jeahoon; Kim, Byunggik; Chung, Ha Uk; Lee, Dongjun; Yang, Yiyuan; Cho, Moongee; Gaspar, John G; Carbonari, Ronald; Fabiani, Monica; Gratton, Gabriele; Huang, Yonggang; Rogers, John A

2014-09-03

Research in stretchable electronics involves fundamental scientific topics relevant to applications with importance in human healthcare. Despite significant progress in active components, routes to mechanically robust construction are lacking. Here, we introduce materials and composite designs for thin, breathable, soft electronics that can adhere strongly to the skin, with the ability to be applied and removed hundreds of times without damaging the devices or the skin, even in regions with substantial topography and coverage of hair. The approach combines thin, ultralow modulus, cellular silicone materials with elastic, strain-limiting fabrics, to yield a compliant but rugged platform for stretchable electronics. Theoretical and experimental studies highlight the mechanics of adhesion and elastic deformation. Demonstrations include cutaneous optical, electrical and radio frequency sensors for measuring hydration state, electrophysiological activity, pulse and cerebral oximetry. Multipoint monitoring of a subject in an advanced driving simulator provides a practical example.

Using Science Data and Models for Space Weather Forecasting - Challenges and Opportunities

NASA Technical Reports Server (NTRS)

Hesse, Michael; Pulkkinen, Antti; Zheng, Yihua; Maddox, Marlo; Berrios, David; Taktakishvili, Sandro; Kuznetsova, Masha; Chulaki, Anna; Lee, Hyesook; Mullinix, Rick;

Translational plant proteomics: a perspective.

PubMed

Agrawal, Ganesh Kumar; Pedreschi, Romina; Barkla, Bronwyn J; Bindschedler, Laurence Veronique; Cramer, Rainer; Sarkar, Abhijit; Renaut, Jenny; Job, Dominique; Rakwal, Randeep

2012-08-03

Translational proteomics is an emerging sub-discipline of the proteomics field in the biological sciences. Translational plant proteomics aims to integrate knowledge from basic sciences to translate it into field applications to solve issues related but not limited to the recreational and economic values of plants, food security and safety, and energy sustainability. In this review, we highlight the substantial progress reached in plant proteomics during the past decade which has paved the way for translational plant proteomics. Increasing proteomics knowledge in plants is not limited to model and non-model plants, proteogenomics, crop improvement, and food analysis, safety, and nutrition but to many more potential applications. Given the wealth of information generated and to some extent applied, there is the need for more efficient and broader channels to freely disseminate the information to the scientific community. This article is part of a Special Issue entitled: Translational Proteomics. Copyright © 2012 Elsevier B.V. All rights reserved.

Next-generation Digital Earth.

PubMed

Goodchild, Michael F; Guo, Huadong; Annoni, Alessandro; Bian, Ling; de Bie, Kees; Campbell, Frederick; Craglia, Max; Ehlers, Manfred; van Genderen, John; Jackson, Davina; Lewis, Anthony J; Pesaresi, Martino; Remetey-Fülöpp, Gábor; Simpson, Richard; Skidmore, Andrew; Wang, Changlin; Woodgate, Peter

2012-07-10

A speech of then-Vice President Al Gore in 1998 created a vision for a Digital Earth, and played a role in stimulating the development of a first generation of virtual globes, typified by Google Earth, that achieved many but not all the elements of this vision. The technical achievements of Google Earth, and the functionality of this first generation of virtual globes, are reviewed against the Gore vision. Meanwhile, developments in technology continue, the era of "big data" has arrived, the general public is more and more engaged with technology through citizen science and crowd-sourcing, and advances have been made in our scientific understanding of the Earth system. However, although Google Earth stimulated progress in communicating the results of science, there continue to be substantial barriers in the public's access to science. All these factors prompt a reexamination of the initial vision of Digital Earth, and a discussion of the major elements that should be part of a next generation.

Network neuroscience

PubMed Central

Bassett, Danielle S; Sporns, Olaf

2017-01-01

Despite substantial recent progress, our understanding of the principles and mechanisms underlying complex brain function and cognition remains incomplete. Network neuroscience proposes to tackle these enduring challenges. Approaching brain structure and function from an explicitly integrative perspective, network neuroscience pursues new ways to map, record, analyze and model the elements and interactions of neurobiological systems. Two parallel trends drive the approach: the availability of new empirical tools to create comprehensive maps and record dynamic patterns among molecules, neurons, brain areas and social systems; and the theoretical framework and computational tools of modern network science. The convergence of empirical and computational advances opens new frontiers of scientific inquiry, including network dynamics, manipulation and control of brain networks, and integration of network processes across spatiotemporal domains. We review emerging trends in network neuroscience and attempt to chart a path toward a better understanding of the brain as a multiscale networked system. PMID:28230844

Rugged and breathable forms of stretchable electronics with adherent composite substrates for transcutaneous monitoring

NASA Astrophysics Data System (ADS)

Jang, Kyung-In; Han, Sang Youn; Xu, Sheng; Mathewson, Kyle E.; Zhang, Yihui; Jeong, Jae-Woong; Kim, Gwang-Tae; Webb, R. Chad; Lee, Jung Woo; Dawidczyk, Thomas J.; Kim, Rak Hwan; Song, Young Min; Yeo, Woon-Hong; Kim, Stanley; Cheng, Huanyu; Rhee, Sang Il; Chung, Jeahoon; Kim, Byunggik; Chung, Ha Uk; Lee, Dongjun; Yang, Yiyuan; Cho, Moongee; Gaspar, John G.; Carbonari, Ronald; Fabiani, Monica; Gratton, Gabriele; Huang, Yonggang; Rogers, John A.

2014-09-01

Research in stretchable electronics involves fundamental scientific topics relevant to applications with importance in human healthcare. Despite significant progress in active components, routes to mechanically robust construction are lacking. Here, we introduce materials and composite designs for thin, breathable, soft electronics that can adhere strongly to the skin, with the ability to be applied and removed hundreds of times without damaging the devices or the skin, even in regions with substantial topography and coverage of hair. The approach combines thin, ultralow modulus, cellular silicone materials with elastic, strain-limiting fabrics, to yield a compliant but rugged platform for stretchable electronics. Theoretical and experimental studies highlight the mechanics of adhesion and elastic deformation. Demonstrations include cutaneous optical, electrical and radio frequency sensors for measuring hydration state, electrophysiological activity, pulse and cerebral oximetry. Multipoint monitoring of a subject in an advanced driving simulator provides a practical example.

Pharmacoinformatic approaches to understand complexation of dendrimeric nanoparticles with drugs

NASA Astrophysics Data System (ADS)

Jain, Vaibhav; Bharatam, Prasad V.

2014-02-01

Nanoparticle based drug delivery systems are gaining popularity due to their wide spectrum advantages over traditional drug delivery systems; among them, dendrimeric nano-vectors are the most widely explored carriers for pharmaceutical and biomedical applications. The precise mechanism of encapsulation of drug molecules inside the dendritic matrix, delivery of drugs into specific cells, interactions of nano-formulation with biological targets and proteins, etc. present a substantial challenge to the scientific understanding of the subject. Computational methods complement experimental techniques in the design and optimization of drug delivery systems, thus minimizing the investment in drug design and development. Significant progress in computer simulations could facilitate an understanding of the precise mechanism of encapsulation of bioactive molecules and their delivery. This review summarizes the pharmacoinformatic studies spanning from quantum chemical calculations to coarse-grained simulations, aimed at providing better insight into dendrimer-drug interactions and the physicochemical parameters influencing the binding and release mechanism of drugs.

[Professor Kazimierz Jaegermann--forensic pathologist--scientist--thinker].

PubMed

Nasiłowski, Władysław

2009-01-01

Professor Kazimierz Jaegermann, a founder of the theory of medico-legal opinionating, passed away 20 years ago. Numerous specialists in forensic medicine and an ever increasing number of lawyers substantiate the importance and value of the creative thought and the entire research work of Professor Jaegermann that have been an inspiration of progress in forensic medicine and in the science of applied law. His unique ability to perform a scientific synthesis leading to recognizing forensic medicine as an applied bridging knowledge points to the eminently creative role played by Professor Jaegermann in development of forensic medicine. There is an urgent need to recall his research activities and to publish a complete collection of his articles and publications. With this idea in mind, I present below an article based on the text published in No. 1 of the Zeszyty Naukowe Katedry Medycyny Sadowej Slaskiej Akademii Medycznej in 1995.

Developing a Measure of Scientific Literacy for Middle School Students

ERIC Educational Resources Information Center

Fives, Helenrose; Huebner, Wendy; Birnbaum, Amanda S.; Nicolich, Mark

2014-01-01

Scientific literacy reflects "a broad and functional understanding of science for general education purposes" (DeBoer, [DeBoer, G. E., 2000], p. 594). Herein, we present the ongoing development of the Scientific Literacy Assessment (SLA), a work-in-progress measure to assess middle school students' (ages 11-14) scientific literacy.…

Counting Highly Cited Papers for University Research Assessment: Conceptual and Technical Issues

PubMed Central

Rodríguez-Navarro, Alonso

2012-01-01

A Kuhnian approach to research assessment requires us to consider that the important scientific breakthroughs that drive scientific progress are infrequent and that the progress of science does not depend on normal research. Consequently, indicators of research performance based on the total number of papers do not accurately measure scientific progress. Similarly, those universities with the best reputations in terms of scientific progress differ widely from other universities in terms of the scale of investments made in research and in the higher concentrations of outstanding scientists present, but less so in terms of the total number of papers or citations. This study argues that indicators for the 1% high-citation tail of the citation distribution reveal the contribution of universities to the progress of science and provide quantifiable justification for the large investments in research made by elite research universities. In this tail, which follows a power low, the number of the less frequent and highly cited important breakthroughs can be predicted from the frequencies of papers in the upper part of the tail. This study quantifies the false impression of excellence produced by multinational papers, and by other types of papers that do not contribute to the progress of science. Many of these papers are concentrated in and dominate lists of highly cited papers, especially in lower-ranked universities. The h-index obscures the differences between higher- and lower-ranked universities because the proportion of h-core papers in the 1% high-citation tail is not proportional to the value of the h-index. PMID:23071759

Counting highly cited papers for university research assessment: conceptual and technical issues.

PubMed

Rodríguez-Navarro, Alonso

2012-01-01

A Kuhnian approach to research assessment requires us to consider that the important scientific breakthroughs that drive scientific progress are infrequent and that the progress of science does not depend on normal research. Consequently, indicators of research performance based on the total number of papers do not accurately measure scientific progress. Similarly, those universities with the best reputations in terms of scientific progress differ widely from other universities in terms of the scale of investments made in research and in the higher concentrations of outstanding scientists present, but less so in terms of the total number of papers or citations. This study argues that indicators for the 1% high-citation tail of the citation distribution reveal the contribution of universities to the progress of science and provide quantifiable justification for the large investments in research made by elite research universities. In this tail, which follows a power low, the number of the less frequent and highly cited important breakthroughs can be predicted from the frequencies of papers in the upper part of the tail. This study quantifies the false impression of excellence produced by multinational papers, and by other types of papers that do not contribute to the progress of science. Many of these papers are concentrated in and dominate lists of highly cited papers, especially in lower-ranked universities. The h-index obscures the differences between higher- and lower-ranked universities because the proportion of h-core papers in the 1% high-citation tail is not proportional to the value of the h-index.

Students' Argumentation Skills across Two Socio-Scientific Issues in a Confucian Classroom: Is transfer possible?

NASA Astrophysics Data System (ADS)

Foong, Chan-Choong; Daniel, Esther G. S.

2013-09-01

This paper argues the possible simultaneous development and transfer of students' argumentation skills from one socio-scientific issue to another in a Confucian classroom. In Malaysia, the Chinese vernacular schools follow a strict Confucian philosophy in the teaching and learning process. The teacher talks and the students listen. This case study explored the transfer of argumentation skills across two socio-scientific issues in such a Form 2 (8th grade) classroom. An instructional support to complement the syllabus was utilised. The teaching approach in the instructional support was more constructivist in nature and designed to introduce argumentation skills which is uncommon in a Confucian classroom. The two socio-scientific issues were genetically modified foods and deforestation. This paper presents a part of the bigger case study that was conducted. Data collected from written arguments were analysed using an analytical framework built upon Toulmin's ideas. The whole class analysis indicated progression in students' argumentation skills in their ability to give more valid grounds and rebuttals during the transfer. The individual analysis suggests progression in the majority of students' performance, while several students demonstrated non-progression when they faced a different socio-scientific issue.

Creationism and intelligent design are incompatible with scientific progress: A response to Shanta and Vêdanta

PubMed Central

Caetano-Anollés, Gustavo

2016-01-01

ABSTRACT In a recent opinion paper, B.K. Shanta claims science leaves no room for the subjective aspect of consciousness, and in doing so, attacks both origin of life and evolutionary research. He claims Vêdanta, one of the 6 orthodox schools of Hindu philosophy, offers an explanation: “the origin of everything material and nonmaterial is sentient and absolute.” Here I discuss how the pseudoscience of these creationist views, which are aligned with Intelligent Design, are incompatible with scientific progress and should not be published in scientific journals. PMID:27066185

Solar and Space Physics Science Enabled by Pico and Nano Satellites

NASA Astrophysics Data System (ADS)

Swenson, C.; Fish, C. S.

2012-12-01

The most significant advances in solar and space physics, or Heliophysics, over the next decade are most likely to derive from new observational techniques. The connection between advances in scientific understanding and technology has historically been demonstrated across many disciplines and time. Progress on some of the most compelling scientific problems will most likely occur through multipoint observations within the space environment to understand the coupling between disparate regions: Heliosphere, magnetosphere, ionosphere, thermosphere and mesosphere. Multipoint measurements are also needed to develop understanding of the various scalars or vector field signatures (i.e gradients, divergence) that arise from coupling processes that occur across temporal and spatial scales or within localized regions. The resources that are available over the next decades for all areas of Heliophysics research have limits and it is therefore important that the community be innovative in developing new observational techniques to advance science. One of the most promising new observational techniques becoming available are miniaturized sensors and satellite systems called pico- or nano-satellites and CubeSats. These are enabled by the enormous investment of the commercial, medical, and defense industries in producing highly capable, portable and low-power battery-operated consumer electronics, in-situ composition probes, and novel reconnaissance sensors. The advancements represented by these technologies have direct application in developing pico- or nano-satellites and CubeSats system for Heliophysics research. In this talk we overview the current environment and technologies surrounding these novel small satellites and discuss the types and capabilities of the miniature sensors that are being developed. We discuss how pico- or nano-satellites and CubeSats can be used to address highest priority science identified in the Decadal Survey and the innovations and advancements that are required to make substantial progress.

16 CFR 260.5 - Interpretation and substantiation of environmental marketing claims.

Code of Federal Regulations, 2010 CFR

2010-01-01

... reliable scientific evidence, defined as tests, analyses, research, studies or other evidence based on the... Statement on the Advertising Substantiation Doctrine. 49 FR 30999 (1984); appended to Thompson Medical Co... deceptive or unsubstantiated environmental advertising claims. A current list of environmental marketing...

The Experimental Social Scientific Model in Speech Communication Research: Influences and Consequences.

ERIC Educational Resources Information Center

Ferris, Sharmila Pixy

A substantial number of published articles in speech communication research today is experimental/social scientific in nature. It is only in the past decade that scholars have begun to put the history of communication under the lens. Early advocates of the adoption of the method of social scientific inquiry were J. A. Winans, J. M. O'Neill, and C.…

What Is Scientifically-Based Research on Progress Monitoring?

ERIC Educational Resources Information Center

Fuchs, Lynn S.; Fuchs, Douglas

2001-01-01

When teachers use systematic progress monitoring to track their students progress in reading, mathematics, or spelling, they are better able to identify students in need of additional or different forms of instruction, they design stronger instructional programs, and their students achieve better. This document first describes progress monitoring…

ANNUAL REPORT, JULY 1, 1957

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1958-10-31

The progress and trends of research are presented along with a description of operational, service, end administrative activities. Some scientific and technical details are given on research programs in the physical sciences, life sciences, and engineering, however, more complete technical information is available in quarterly progress reports, BNL technical reports, and scientific and technical periodicals. A bibliography of these publications is appended. (For preceding period see BNL-426.) (D.E.B.)

The development of scientific thinking in elementary school: a comprehensive inventory.

PubMed

Koerber, Susanne; Mayer, Daniela; Osterhaus, Christopher; Schwippert, Knut; Sodian, Beate

2015-01-01

The development of scientific thinking was assessed in 1,581 second, third, and fourth graders (8-, 9-, 10-year-olds) based on a conceptual model that posits developmental progression from naïve to more advanced conceptions. Using a 66-item scale, five components of scientific thinking were addressed, including experimental design, data interpretation, and understanding the nature of science. Unidimensional and multidimensional item response theory analyses supported the instrument's reliability and validity and suggested that the multiple components of scientific thinking form a unitary construct, independent of verbal or reasoning skills. A partial credit model gave evidence for a hierarchical developmental progression. Across each grade transition, advanced conceptions increased while naïve conceptions decreased. Independent effects of intelligence, schooling, and parental education on scientific thinking are discussed. © 2014 The Authors. Child Development © 2014 Society for Research in Child Development, Inc.

Ensuring Sustainable Data Interoperability Across the Natural and Social Sciences

NASA Astrophysics Data System (ADS)

Downs, R. R.; Chen, R. S.

2015-12-01

Both the natural and social science data communities are attempting to address the long-term sustainability of their data infrastructures in rapidly changing research, technological, and policy environments. Many parts of these communities are also considering how to improve the interoperability and integration of their data and systems across natural, social, health, and other domains. However, these efforts have generally been undertaken in parallel, with little thought about how different sustainability approaches may impact long-term interoperability from scientific, legal, or economic perspectives, or vice versa, i.e., how improved interoperability could enhance—or threaten—infrastructure sustainability. Scientific progress depends substantially on the ability to learn from the legacy of previous work available for current and future scientists to study, often by integrating disparate data not previously assembled. Digital data are less likely than scientific publications to be usable in the future unless they are managed by science-oriented repositories that can support long-term data access with the documentation and services needed for future interoperability. We summarize recent discussions in the social and natural science communities on emerging approaches to sustainability and relevant interoperability activities, including efforts by the Belmont Forum E-Infrastructures project to address global change data infrastructure needs; the Group on Earth Observations to further implement data sharing and improve data management across diverse societal benefit areas; and the Research Data Alliance to develop legal interoperability principles and guidelines and to address challenges faced by domain repositories. We also examine emerging needs for data interoperability in the context of the post-2015 development agenda and the expected set of Sustainable Development Goals (SDGs), which set ambitious targets for sustainable development, poverty reduction, and environmental stewardship by 2030. These efforts suggest the need for a holistic approach towards improving and implementing strategies, policies, and practices that will ensure long-term sustainability and interoperability of scientific data repositories and networks across multiple scientific domains.

The critical role of volcano monitoring in risk reduction

USGS Publications Warehouse

Tilling, R.I.

2008-01-01

Data from volcano-monitoring studies constitute the only scientifically valid basis for short-term forecasts of a future eruption, or of possible changes during an ongoing eruption. Thus, in any effective hazards-mitigation program, a basic strategy in reducing volcano risk is the initiation or augmentation of volcano monitoring at historically active volcanoes and also at geologically young, but presently dormant, volcanoes with potential for reactivation. Beginning with the 1980s, substantial progress in volcano-monitoring techniques and networks - ground-based as well space-based - has been achieved. Although some geochemical monitoring techniques (e.g., remote measurement of volcanic gas emissions) are being increasingly applied and show considerable promise, seismic and geodetic methods to date remain the techniques of choice and are the most widely used. Availability of comprehensive volcano-monitoring data was a decisive factor in the successful scientific and governmental responses to the reawakening of Mount St. Helens (Washington, USA) in 1980 and, more recently, to the powerful explosive eruptions at Mount Pinatubo (Luzon, Philippines) in 1991. However, even with the ever-improving state-ofthe-art in volcano monitoring and predictive capability, the Mount St. Helens and Pinatubo case histories unfortunately still represent the exceptions, rather than the rule, in successfully forecasting the most likely outcome of volcano unrest.

White paper on nuclear astrophysics and low-energy nuclear physics, Part 2: Low-energy nuclear physics

NASA Astrophysics Data System (ADS)

Carlson, Joe; Carpenter, Michael P.; Casten, Richard; Elster, Charlotte; Fallon, Paul; Gade, Alexandra; Gross, Carl; Hagen, Gaute; Hayes, Anna C.; Higinbotham, Douglas W.; Howell, Calvin R.; Horowitz, Charles J.; Jones, Kate L.; Kondev, Filip G.; Lapi, Suzanne; Macchiavelli, Augusto; McCutchen, Elizabeth A.; Natowitz, Joe; Nazarewicz, Witold; Papenbrock, Thomas; Reddy, Sanjay; Riley, Mark A.; Savage, Martin J.; Savard, Guy; Sherrill, Bradley M.; Sobotka, Lee G.; Stoyer, Mark A.; Betty Tsang, M.; Vetter, Kai; Wiedenhoever, Ingo; Wuosmaa, Alan H.; Yennello, Sherry

2017-05-01

Over the last decade, the Low-Energy Nuclear Physics (LENP) and Nuclear Astrophysics (NAP) communities have increasingly organized themselves in order to take a coherent approach to resolving the challenges they face. As a result, there is a high level of optimism in view of the unprecedented opportunities for substantial progress. In preparation of the 2015 US Nuclear Science Long Range Plan (LRP), the two American Physical Society Division of Nuclear Physics town meetings on LENP and NAP were held jointly on August 21-23, 2014, at Texas A&M, College Station, in Texas. These meetings were co-organized to take advantage of the strong synergy between the two fields. The present White Paper attempts to communicate the sense of great anticipation and enthusiasm that came out of these meetings. A unanimously endorsed set of joint resolutions condensed from the individual recommendations of the two town meetings were agreed upon. The present LENP White Paper discusses the above and summarizes in detail for each of the sub-fields within low-energy nuclear physics, the major accomplishments since the last LRP, the compelling near-term and long-term scientific opportunities plus the resources needed to achieve these goals, along with the scientific impact on, and interdisciplinary connections to, other fields.

48 CFR 1852.219-82 - Limitation on subcontracting-STTR program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... performed by the research institution. Since the selection of R&D contractors is substantially based on the best scientific and technological sources, it is important that the Contractor not subcontract technical or scientific work without the Contracting Officer's advance approval. (End of clause) [71 FR...

48 CFR 1852.219-82 - Limitation on subcontracting-STTR program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... performed by the research institution. Since the selection of R&D contractors is substantially based on the best scientific and technological sources, it is important that the Contractor not subcontract technical or scientific work without the Contracting Officer's advance approval. (End of clause) [71 FR...

48 CFR 1852.219-82 - Limitation on subcontracting-STTR program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... performed by the research institution. Since the selection of R&D contractors is substantially based on the best scientific and technological sources, it is important that the Contractor not subcontract technical or scientific work without the Contracting Officer's advance approval. (End of clause) [71 FR...

48 CFR 1852.219-82 - Limitation on subcontracting-STTR program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... performed by the research institution. Since the selection of R&D contractors is substantially based on the best scientific and technological sources, it is important that the Contractor not subcontract technical or scientific work without the Contracting Officer's advance approval. (End of clause) [71 FR...

48 CFR 1852.219-82 - Limitation on subcontracting-STTR program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... performed by the research institution. Since the selection of R&D contractors is substantially based on the best scientific and technological sources, it is important that the Contractor not subcontract technical or scientific work without the Contracting Officer's advance approval. (End of clause) [71 FR...

What do we really know about the signalling role of plumage colour in blue tits? A case study of impediments to progress in evolutionary biology.

PubMed

Parker, Timothy H

2013-08-01

Evolutionary biologists seek to explain the origin and maintenance of phenotypes, and a substantial portion of this research is accomplished by thorough study of individual species. For instance, many researchers study individual species to understand evolution of ornamental traits which appear to be products of sexual selection. I explored our understanding of sexual ornaments in a well-studied vertebrate species that may serve as a case study for research programs in evolutionary biology. I attempted to located all published papers examining plumage colour and variables related to sexual selection hypotheses in a common European songbird, the blue tit (Cyanistes caeruleus). Researchers have estimated over 1200 statistical relationships with plumage colour of blue tits in 52 studies. However, of the approximately 1000 main-effect relationships from the 48 studies that are candidates for inclusion in this meta-analysis, more than 400 were reported without details of strength and direction. Circumstantial evidence suggests that an unknown number of other estimated effects remain unpublished. Missing information is a substantial barrier to interpretation of these papers and to meta-analytic synthesis. Examination and analysis of funnel plots indicated that unpublished effects may be a biased sample of all effects, especially for comparisons of plumage colour to age and individual quality, and possibly also to measures of mate choice. Further, type I error was likely elevated by the large number of statistical comparisons evaluated, the frequent use of iterative model-building procedures, and a willingness to interpret a wide variety of results as support for a hypothesis. Type I errors were made more problematic because blue tit plumage researchers only rarely have attempted to replicate important findings in their own work or that of others. Replication is essential to drawing robust scientific conclusions, especially in probabilistic systems with moderate to weak effects or a likelihood of bias. Last, researchers studying blue tit plumage have often developed ad hoc explanations for deviations of results from their predictions. Revising hypotheses in light of data is appropriate, but these revised hypotheses were rarely tested with new data. The only highly robust conclusion supported by meta-analysis is that male blue tits have plumage that reflects more light in the ultraviolet and yellow wavelengths than the plumage of females. Various other effects, including condition-dependence of plumage colour expression and a tendency for females to adjust the sex ratio of their offspring in response to male colour, remain uncertain. These obstacles to progress in the blue tit plumage literature are likely common in evolutionary biology, and so I recommend changes to incentive structures which may improve progress towards scientific understanding in this discipline. © 2012 The Authors. Biological Reviews © 2012 Cambridge Philosophical Society.

Convergence of advances in genomics, team science, and repositories as drivers of progress in psychiatric genomics.

PubMed

Lehner, Thomas; Senthil, Geetha; Addington, Anjené M

2015-01-01

After many years of unfilled promise, psychiatric genetics has seen an unprecedented number of successes in recent years. We hypothesize that the field has reached an inflection point through a confluence of four key developments: advances in genomics; the orientation of the scientific community around large collaborative team science projects; the development of sample and data repositories; and a policy framework for sharing and accessing these resources. We discuss these domains and their effect on scientific progress and provide a perspective on why we think this is only the beginning of a new era in scientific discovery. Published by Elsevier Inc.

16 CFR 260.5 - Interpretation and substantiation of environmental marketing claims.

Code of Federal Regulations, 2011 CFR

2011-01-01

... reasonable basis substantiating the claim. A reasonable basis consists of competent and reliable evidence. In... reliable scientific evidence, defined as tests, analyses, research, studies or other evidence based on the... qualified to do so, using procedures generally accepted in the profession to yield accurate and reliable...

48 CFR 1852.219-81 - Limitation on subcontracting-SBIR Phase II program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... must be approved in advance and in writing by the Contracting Officer. Since the selection of R&D contractors is substantially based on the best scientific and technological sources, it is important that the Contractor not subcontract technical or scientific work without the Contracting Officer's advance approval...

48 CFR 1852.219-81 - Limitation on subcontracting-SBIR Phase II program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... must be approved in advance and in writing by the Contracting Officer. Since the selection of R&D contractors is substantially based on the best scientific and technological sources, it is important that the Contractor not subcontract technical or scientific work without the Contracting Officer's advance approval...

Designing a Technology-Enhanced Learning Environment to Support Scientific Modeling

ERIC Educational Resources Information Center

Wu, Hsin-Kai; Hsu, Ying-Shao; Hwang, Fu-Kwun

2010-01-01

Modeling of a natural phenomenon is of value in science learning and increasingly emphasized as an important component of science education. However, previous research has shown that secondary school students encounter difficulties when engaging in modeling activities and need substantial support in order to create meaningful scientific models.…

Use of botanicals in food supplements. Regulatory scope, scientific risk assessment and claim substantiation. 2005.

PubMed

Coppens, P; Delmulle, L; Gulati, O; Richardson, D; Ruthsatz, M; Sievers, H; Sidani, S

2006-01-01

In the European Union, an elaborate legal framework regulates botanical products both under food and medicinal law. The decision as to which legal framework applies to an individual product may differ between the Member States. In the case of botanical food supplements, all food law provisions apply to their manufacturing, composition and marketing, including the new claims legislation. Elements from EU and national law, scientific and other publications are brought together to investigate how to clarify the differentiation between the use of botanicals for medicinal and health-promoting purposes on a scientific basis. Guidance on the safety assessment and quality evaluation of botanicals is proposed in light of the different approaches described in the scientific literature with particular attention to the concept of long-term use as an integral part of safety evaluation. Guidance on claims substantiation is also included, taking into consideration the proposed legislation, the concept of long-term experience and grading of evidence. A model for safety and efficacy assessment of botanical food supplements in the EU is proposed, and should be taken into consideration in the development of legislation and scientific research on botanicals. Copyright 2006 S. Karger AG, Basel.

Mapping and predicting sinkholes by integration of remote sensing and spectroscopy methods

NASA Astrophysics Data System (ADS)

Goldshleger, N.; Basson, U.; Azaria, I.

2013-08-01

The Dead Sea coastal area is exposed to the destructive process of sinkhole collapse. The increase in sinkhole activity in the last two decades has been substantial, resulting from the continuous decrease in the Dead Sea's level, with more than 1,000 sinkholes developing as a result of upper layer collapse. Large sinkholes can reach 25 m in diameter. They are concentrated mainly in clusters in several dozens of sites with different characteristics. In this research, methods for mapping, monitoring and predicting sinkholes were developed using active and passive remote-sensing methods: field spectrometer, geophysical ground penetration radar (GPR) and a frequency domain electromagnetic instrument (FDEM). The research was conducted in three stages: 1) literature review and data collection; 2) mapping regions abundant with sinkholes in various stages and regions vulnerable to sinkholes; 3) analyzing the data and translating it into cognitive and accessible scientific information. Field spectrometry enabled a comparison between the spectral signatures of soil samples collected near active or progressing sinkholes, and those collected in regions with no visual sign of sinkhole occurrence. FDEM and GPR investigations showed that electrical conductivity and soil moisture are higher in regions affected by sinkholes. Measurements taken at different time points over several seasons allowed monitoring the progress of an 'embryonic' sinkhole.

United States Food and Drug Administration and Department of Defense shelf-life extension program of pharmaceutical products: progress and promise.

PubMed

Khan, Saeed R; Kona, Ravikanth; Faustino, Patrick J; Gupta, Abhay; Taylor, Jeb S; Porter, Donna A; Khan, Mansoor

2014-05-01

The Department of Defense (DoD)-United States Food and Drug Administration (FDA) shelf-life extension program (SLEP) was established in 1986 through an intra-agency agreement between the DoD and the FDA to extend the shelf life of product nearing expiry. During the early stages of development, special attention was paid to program operation, labeling requirements, and the cost benefits associated with this program. In addition to the substantial cost benefits, the program also provides the FDA's Center for Drug Evaluation and Research with significant scientific understanding and pharmaceutical resource. As a result of this unique resource, numerous regulatory research opportunities to improve public health present themselves from this distinctive scientific database, which includes examples of products shelf life, their long-term stability issues, and various physical and chemical tests to identify such failures. The database also serves as a scientific resource for mechanistic understanding and identification of test failures leading to the development of new formulations or more robust packaging. It has been recognized that SLEP is very important in maintaining both national security and public welfare by confirming that the stockpiled pharmaceutical products meet quality standards after the "expiration date" assigned by the sponsor. SLEP research is an example of regulatory science that is needed to best ensure product performance past the original shelf life. The objective of this article is to provide a brief history and background and most importantly the public health benefits of the SLEP. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

Synthesis of current knowledge on post-fire seeding for soil stabilization and invasive species control

USGS Publications Warehouse

Beyers, Jan L.; Pyke, David A.; Wirth, Troy

2015-01-01

The General Accounting Office has identified a need for better information on the effectiveness of post-fire emergency stabilization and rehabilitation methods used by the U.S. Forest Service and Department of Interior (DOI) agencies. Since reviews were published on treatment effectiveness in the early 2000s, treatment choices have changed and increased monitoring has been done. Greater use of native species has added substantially to burned area emergency response (BAER) treatment costs, for example, but quantitative data on this treatment were scarce in earlier reviews. We synthesized current information on the effectiveness of post-fire seeding for both soil stabilization and for prevention of the spread of invasive species in rangelands. We reviewed published literature (peer-reviewed and “gray”) and agency monitoring reports, as well as compiled and analyzed quantitative data in agency files. Products of this review include a web-accessible database of monitoring reports and published information, a scientific journal paper summarizing findings of scientific studies, an annotated bibliography of peer-reviewed papers, a summary report published as a General Technical Report that will be available online (in progress), and presentations to scientific meetings and BAER/ESR team training sessions and workshops. By combining results from studies done by Forest Service and DOI agency personnel with research studies published since the initial reviews, we presented a comprehensive synthesis of seeding effectiveness knowledge that complements the review of other hillslope treatments published by other researchers. This information will help federal land managers make more cost-effective decisions on post-fire stabilization and rehabilitation treatments.

Stakeholders' perception of the nutrition and health claim regulation.

PubMed

de Boer, Alie; Bast, Aalt

2015-05-01

In 2007, the Nutrition and Health Claim Regulation (NHCR) entered into force, which required scientific substantiation of health claims. In the field of antioxidants, most proposed claims were negatively assessed by the European Food Safety Authority (EFSA). This study reviews the perception of the NHCR of 14 Dutch stakeholders to unravel the grounds for disproving the putative health claims. Most claims are shown to be refused based on the quality of scientific substantiation, due to usage of scientific methods on which no consensus has been reached and the differences in expectations and requirements. Three themes exemplify the need for improvement in applying the NHCR: (i) enforcement; (ii) methodology; and (iii) perceived impact of the NHCR. With highly diverging perceptions of stakeholders, the current effectiveness of the NHCR can be questioned. The views of different stakeholders on these themes help to focus the discussion on the NCHR in capturing health effects.

42 CFR 82.30 - How will NIOSH inform the public of any plans to change scientific elements underlying the dose...

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES METHODS FOR... change scientific elements underlying the dose reconstruction process to maintain methods reasonably... methods reasonably current with scientific progress? Periodically, NIOSH will publish a notice in the...

Computational chemistry in pharmaceutical research: at the crossroads.

PubMed

Bajorath, Jürgen

2012-01-01

Computational approaches are an integral part of pharmaceutical research. However, there are many of unsolved key questions that limit the scientific progress in the still evolving computational field and its impact on drug discovery. Importantly, a number of these questions are not new but date back many years. Hence, it might be difficult to conclusively answer them in the foreseeable future. Moreover, the computational field as a whole is characterized by a high degree of heterogeneity and so is, unfortunately, the quality of its scientific output. In light of this situation, it is proposed that changes in scientific standards and culture should be seriously considered now in order to lay a foundation for future progress in computational research.

Formation of Professional Competence of Legal Specialty Students in the Elective Courses Studying

ERIC Educational Resources Information Center

Akhmejanova, Gulnara; Olzhabayev, Bulat; Grigoryeva, Roza; Karibaeva, Zhanara; Avilkhan, Akmamyk; Sakenov, Janat

2016-01-01

This article examines the scientific problem of the formation of professional competence of legal specialty students in the elective courses studying. The analysis has been conducted and the content of professional competence of legal specialty students has been substantiated. This work substantiates the role of elective courses in the formation…

Sustainability in Bioscience Fieldwork: Practical Information from a UK Agricultural Research Institute

ERIC Educational Resources Information Center

Wright, Hazel A.; Ironside, Joseph E.; Gwynn-Jones, Dylan

2009-01-01

Purpose: Owing to the specialist nature of biological experimentation, scientific research staff have been largely neglected from the pro-environmental initiatives which have inundated other areas of higher education. This dearth of studies is surprising given that scientific research is recognised as a substantial contributor to the environmental…

77 FR 32922 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist or...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-04

...-1113-0000-C5] Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist or... petition presents substantial scientific or commercial information indicating that the petitioned actions.... To ensure that these status reviews are comprehensive, we are requesting scientific and commercial...

Networking for High Energy and Nuclear Physics

NASA Astrophysics Data System (ADS)

Newman, Harvey B.

2007-07-01

This report gives an overview of the status and outlook for the world's research networks and major international links used by the high energy physics and other scientific communities, network technology advances on which our community depends and in which we have an increasingly important role, and the problem of the Digital Divide, which is a primary focus of ICFA's Standing Committee on Inter-regional Connectivity (SCIC). Wide area networks of sufficient, and rapidly increasing end-to-end capability are vital for every phase of high energy physicists' work. Our bandwidth usage, and the typical capacity of the major national backbones and intercontinental links used by our field have progressed by a factor of more than 1000 over the past decade, and the outlook is for a similar increase over the next decade. This striking exponential growth trend, outstripping the growth rates in other areas of information technology, has continued in the past year, with many of the major national, continental and transoceanic networks supporting research and education progressing from a 10 Gigabits/sec (Gbps) backbone to multiple 10 Gbps links in their core. This is complemented by the use of point-to-point "light paths" to support the most demanding applications, including high energy physics, in a growing list of cases. As we approach the era of LHC physics, the growing need to access and transport Terabyte-scale and later 10 to 100 Terabyte datasets among more than 100 "Tier1" and "Tier2" centers at universities and laboratories spread throughout the world has brought the key role of networks, and the ongoing need for their development, sharply into focus. Bandwidth itself on an increasing scale is not enough. Realizing the scientific wealth of the LHC and our other major scientific programs depends crucially on our ability to use the bandwidth efficiently and reliably, with reliable high rates of data throughput, and effectively, where many parallel large-scale data transfers serving the community complete with high probability, often while coexisting with many other streams of network traffic. Responding to these needs, and to the scientific mission, physicists working with network engineers and computer scientists have made substantial progress in the development of protocols and systems that promise to meet these needs, placing our community among the world leaders in the development as well as use of large-scale networks. A great deal of work remains, and is continuing. As we advance in these areas, often (as in the past year) with great rapidity, there is a growing danger that we will leave behind our collaborators in regions with less-developed networks, or with regulatory frameworks or business models that put the required networks financially out of reach. This threatens to further open the Digital Divide that already exists among the regions of the world. In 2002, the SCIC recognized the threat that this Divide represents to our global scientific collaborations, and since that time has worked assiduously to reduce or eliminate it; both within our community, and more broadly in the world research community of which HEP is a part.

Pancreatic Cancer-Critical Examination of the Global Research Architecture and Recent Scientific Developments.

PubMed

Schöffel, Norman; Krempel, Meike; Bundschuh, Matthias; Bendels, Michael H; Brüggmann, Dörthe; Groneberg, David A

2016-11-01

Despite decades of effort, the 5-year overall survival rate of pancreatic cancer (PC) remains at only approximately 5%. Until now, no detailed knowledge regarding the worldwide research architecture of PC has yet been established. Hence, we conducted this scientometric analysis to quantify the global research activity in this field. The total research productivity was screened and research output of countries, categories, individual institutions, authors, and their collaborative networks were analyzed by the new quality and quantity indices in science platform. Results were visualized via state-of-the-art density equalizing mapping projections. The results indicated that Japan, Germany, and the United States played a leading role regarding output activity, multilateral, and bilateral cooperations. Within the past decades, the topic PC has developed into a scientific field covering many subject areas. Recently published studies predict that the scientific progress will be mainly depending on international cooperations; we can confirm that development by now. We conclude that the field of PC is constantly progressing in which the influence of international cooperations on the scientific progress is of increasing importance. Nevertheless, research in the field of PC still needs to be strengthened to reduce morbidity and mortality in the future.

Progress toward a cosmic dust collection facility on space station

NASA Technical Reports Server (NTRS)

Mackinnon, Ian D. R. (Editor); Carey, William C. (Editor)

1987-01-01

Scientific and programmatic progress toward the development of a cosmic dust collection facility (CDCF) for the proposed space station is documented. Topics addressed include: trajectory sensor concepts; trajectory accuracy and orbital evolution; CDCF pointing direction; development of capture devices; analytical techniques; programmatic progress; flight opportunities; and facility development.

The Concept of Ecologically Oriented Progress and Natural Resource Preservation

NASA Astrophysics Data System (ADS)

Gasanov, M. A.; Kolotov, K. A.; Demidenko, K. A.; Podgornaya, E. A.; Kadnikova, O. V.

2017-01-01

The most important issue of scientific and technological progress is considering the environment challenges of industrial development. It means that the progress must be ecologically oriented and environmentally friendly. The most adequate concept for the approach to the issue of “man - society - nature” relations is the ontology of the noosphere - the idea of a common space for human beings and nature. It presents an ideal example of an optimistic attitude towards the coordination between accelerating the scientific and technological development and natural resource saving. However, to maintain the balance between human needs and environmental processes determined by this concept, it is essential to include the lean production training into technological development of society.

Current Scientific Progress and Future Scientific Prospects Enabled by Spaceborne Precipitation Radar Measurements

NASA Technical Reports Server (NTRS)

Smith, Eric A.; Im, Eastwood; Tripoli, Gregory J.; Yang, Song

2008-01-01

First, we examine current scientific progress and understanding that have been possible through use of spaceborne precipitation radar measurements being provided by the TRMM and CloudSat satellites. Second, we look across a future 20-year time frame to assess how and why anticipated improvements in space radar systems will further advance scientific progress into topic areas once considered beyond the realm of space-based remote sensing. JAXA's 13.8 GHz Ku-band cross-track scanning Precipitation Radar (PR) developed for flight on NASA's non-sun-synchronous, diurnally-precessing TRMM satellite, was the first Earth radar flown in space that was designed specifically for precipitation measurement. Its proven accuracy in measuring global rainfall in the tropics and sub-tropics and its unanticipated longevity in continuing these measurements beyond a full decade have established the standards against which all follow-up and future space radars will be evaluated. In regards to the current PR measurement time series, we will discuss a selection of major scientific discoveries and impacts which have set the stage for future radar measuring systems. In fact, the 2nd contemporary space radar applicable for terrestrial precipitation measurement, i.e., JPL-CSA's 94 GHz nadir-staring Cloud Profiling Radar (CPR) flown on NASA's sun-synchronous CloudSat satellite, although designed primarily for measurement of non-precipitating cloud hydrometeors and aerosols, has also unquestionably advanced precipitation measurement because CPR's higher frequency and greatly increased sensitivity (approximately 30 dBZ) has enabled global observations of light rain rate spectrum processes (i.e., rain rates below 0.05 mm per hourand of precipitation processes in the high troposphere (particularly ice phase processes). These processes are beyond reach of the TRMM radar because the PR sensitivity limit is approximately 17 dBZ which means its lower rain rate cutoff is around 0.3 mm per hour and its vertical profiling acuity is greatly limited above the melting layer. Thus, the newer CPR measurements have become important for a variety of scientific reasons that will be highlighted and assessed. In considering scientific progress likely to stem from future precipitation radar systems, we will specifically examine possible scientific impacts from three anticipated missions for which NASA and various of its space agency partners are expected to lead the way. These three missions are: (1) the nearterm Global Precipitation Measuring (GPM) Mission; (2) the decadal timeline Aerosol and Cloud Experiment (ACE) Mission; and the post-decadal timeline NEXRAD in Space (NIS) Mission. The observational capabilities of the planned radar systems for each of these three satellite missions are distinct from each other and each provides progressive improvements in precipitation measuring and scientific research capabilities relative to where we are now -- insofar as TRMM PR and the CloudSat CPR capabilities. The potential innovations in scientific research will be discussed in a framework of likely synergisms between next-generation radar capabilities and accessible dynamical and microphysical properties that have heretofore evaded detection.

Vascular knowledge in medieval times was the turning point for the humanistic trend.

PubMed

Ducasse, E; Speziale, F; Baste, J C; Midy, D

2006-06-01

Knowledge of the history of our surgical specialty may broaden our viewpoint for everyday practice. We illustrate the scientific progress made in medieval times relevant to the vascular system and blood circulation, progress made despite prevailing religious and philosophical dogma. We located all articles concerning vascular knowledge and historical reviews in databases such as MEDLINE, EMBASE and the database of abstracts of reviews (DARE). We also explored the database of the register from the French National Library, the French Medical Inter-University (BIUM), the Italian National Library and the French and Italian Libraries in the Vatican. All data were collected and analysed in chronological order. Medieval vascular knowledge was inherited from Greek via Byzantine and Arabic writings, the first controversies against the recognized vascular schema emanating from an Arabian physician in the 13th century. Dissection was forbidden and clerical rules instilled a fear of blood. Major contributions to scientific progress in the vascular field in medieval times came from Ibn-al-Nafis and Harvey. Vascular specialists today may feel proud to recall that once religious dogma declined in early medieval times, vascular anatomic and physiological discoveries led the way to scientific progress.

Science and the Responsibility of Scientists

ERIC Educational Resources Information Center

Markov, Moisey A.

1975-01-01

Discusses the responsibility of scientists to warn mankind about the dangers of the unknown factors of scientific development and the application of science to technical progress. Scientific responsibility for helping reduce politico-military tensions is also put forth. (BR)

42 CFR 82.32 - How will NIOSH make changes in scientific elements underlying the dose reconstruction process...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false How will NIOSH make changes in scientific elements underlying the dose reconstruction process, based on scientific progress? 82.32 Section 82.32 Public Health... AND RELATED ACTIVITIES METHODS FOR CONDUCTING DOSE RECONSTRUCTION UNDER THE ENERGY EMPLOYEES...

42 CFR 82.32 - How will NIOSH make changes in scientific elements underlying the dose reconstruction process...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false How will NIOSH make changes in scientific elements underlying the dose reconstruction process, based on scientific progress? 82.32 Section 82.32 Public Health... AND RELATED ACTIVITIES METHODS FOR CONDUCTING DOSE RECONSTRUCTION UNDER THE ENERGY EMPLOYEES...

42 CFR 82.32 - How will NIOSH make changes in scientific elements underlying the dose reconstruction process...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false How will NIOSH make changes in scientific elements underlying the dose reconstruction process, based on scientific progress? 82.32 Section 82.32 Public Health... AND RELATED ACTIVITIES METHODS FOR CONDUCTING DOSE RECONSTRUCTION UNDER THE ENERGY EMPLOYEES...

42 CFR 82.32 - How will NIOSH make changes in scientific elements underlying the dose reconstruction process...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false How will NIOSH make changes in scientific elements underlying the dose reconstruction process, based on scientific progress? 82.32 Section 82.32 Public Health... AND RELATED ACTIVITIES METHODS FOR CONDUCTING DOSE RECONSTRUCTION UNDER THE ENERGY EMPLOYEES...

Applications of MGS MOC and MOLA Data to Lava Flows: Investigations of Rheology, Topographic Influences and Tectonic Effects

NASA Technical Reports Server (NTRS)

Glaze, Lori S.

2004-01-01

Proxemy Research had a grant from NASA to perform scientific research using Mars Global Surveyor (MGS) data to study lava flows on Mars. Here we summarize the scientific progress and accomplishments of this grant. Scientific publications and abstracts of presentations are indicated in the final section.

Aeronautical education and research at the Swiss Institute of Technology in Zurich

NASA Technical Reports Server (NTRS)

Karner, L; Ackeret, J

1931-01-01

Progress in the scientific and practical fields of aviation has caused the Swiss Institute of Technology to organize lectures and practical training courses in all three branches of aeronautics and to found centers of scientific research, laboratories, etc., in order to supply the government and industries with scientifically and technically trained engineers.

The Development of Scientific Thinking in Elementary School: A Comprehensive Inventory

ERIC Educational Resources Information Center

Koerber, Susanne; Mayer, Daniela; Osterhaus, Christopher; Schwippert, Knut; Sodian, Beate

2015-01-01

The development of scientific thinking was assessed in 1,581 second, third, and fourth graders (8-, 9-, 10-year-olds) based on a conceptual model that posits developmental progression from naïve to more advanced conceptions. Using a 66-item scale, five components of scientific thinking were addressed, including experimental design, data…

Comments on "How Child Protective Services Investigators Decide to Substantiate Mothers for Failure-to-Protect in Sexual Abuse Cases"

ERIC Educational Resources Information Center

Shadoin, Amy L.; Carnes, Connie N.

2006-01-01

This commentary discusses the decisions of child protective service (CPS) investigators to substantiate mothers for failure-to-protect (FTP) in child sexual abuse cases. Four areas are identified in which the scientific literature remains inadequate to fully inform child maltreatment researchers, CPS practitioners and child welfare policymakers on…

76 FR 31920 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Golden...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

...-0028; MO 92210-0-0008] Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To... our review, we find that the petition presents substantial scientific or commercial information... scientific and commercial data and other information regarding this species. Based on the status review, we...

75 FR 13068 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Berry...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

...-0011] [MO 92210-0-0008-B2] Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition... that the petition presents substantial scientific or commercial information indicating that listing... ensure that this status review is comprehensive, we are requesting scientific and commercial data and...

77 FR 37367 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Black...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-21

...-0018; 4500030113] Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List... region. Based on our review, we find that the petition presents substantial scientific or commercial... requesting scientific and commercial data and other information regarding this species. Based on the status...

75 FR 8601 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Sonoran...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

...-0059; MO 92210-0-0008] Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To... all available scientific and commercial information, we find that the Sonoran Desert Area population... the Lists of Endangered and Threatened Wildlife and Plants that contains substantial scientific or...

76 FR 40868 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Bay...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

...-0012; MO 92210-0-0008] Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To... habitat. Based on our review, we find that the petition presents substantial scientific or commercial... warranted. To ensure that this status review is comprehensive, we are requesting scientific and commercial...

Elk Habitat: A Case Study of Scientific Inquiry

ERIC Educational Resources Information Center

Graves, C. John

2009-01-01

A case study is an excellent way to help students think like scientists as they work to solve a dilemma. This article describes a case study of elk in Yellowstone National Park. Students read short narratives, based on scientific research data, about the puzzling question of why some elk live substantially longer than others in certain areas of…

Normal Science and the Paranormal: The Effect of a Scientific Method Course on Students' Beliefs.

ERIC Educational Resources Information Center

Morier, Dean; Keeports, David

1994-01-01

A study investigated the effects of an interdisciplinary course on the scientific method on the attitudes of 34 college students toward the paranormal. Results indicated that the course substantially reduced belief in the paranormal, relative to a control group. Student beliefs in their own paranormal powers, however, did not change. (Author/MSE)

Next-generation Digital Earth

PubMed Central

Goodchild, Michael F.; Guo, Huadong; Annoni, Alessandro; Bian, Ling; de Bie, Kees; Campbell, Frederick; Craglia, Max; Ehlers, Manfred; van Genderen, John; Jackson, Davina; Lewis, Anthony J.; Pesaresi, Martino; Remetey-Fülöpp, Gábor; Simpson, Richard; Skidmore, Andrew; Wang, Changlin; Woodgate, Peter

2012-01-01

A speech of then-Vice President Al Gore in 1998 created a vision for a Digital Earth, and played a role in stimulating the development of a first generation of virtual globes, typified by Google Earth, that achieved many but not all the elements of this vision. The technical achievements of Google Earth, and the functionality of this first generation of virtual globes, are reviewed against the Gore vision. Meanwhile, developments in technology continue, the era of “big data” has arrived, the general public is more and more engaged with technology through citizen science and crowd-sourcing, and advances have been made in our scientific understanding of the Earth system. However, although Google Earth stimulated progress in communicating the results of science, there continue to be substantial barriers in the public’s access to science. All these factors prompt a reexamination of the initial vision of Digital Earth, and a discussion of the major elements that should be part of a next generation. PMID:22723346

Advancing pluripotent stem cell culture: it is a matter of setting the standard.

PubMed

Sartipy, Peter

2013-04-15

Human pluripotent stem cells (hPSCs), defined by their ability to proliferate indefinitely and the capacity to differentiate into all tissue cell types of the adult, represent a platform for the realization of breakthrough technologies for industrial and regenerative medicine applications. We have witnessed tremendous developments over the last decade related to methods for establishment, maintenance, differentiation, and applications of hPSCs and their derivatives. Despite all progress made in the hPSC field, there are still fundamental issues yet to be resolved. For example, our understanding of the pluripotent state remains limited, which in turn may have substantial consequences on how we interpret and communicate scientific data concerning hPSCs. This brief commentary aims to highlight recent important findings that demonstrate additional levels of complexity to the current assessment of pluripotent stem cell cultures. In addition, these data may help to provide some explanations for the challenges in reproducing hPSC differentiation protocols across laboratories.

Assessing National Biodiversity Trends for Rocky and Coral Reefs through the Integration of Citizen Science and Scientific Monitoring Programs.

PubMed

Stuart-Smith, Rick D; Edgar, Graham J; Barrett, Neville S; Bates, Amanda E; Baker, Susan C; Bax, Nicholas J; Becerro, Mikel A; Berkhout, Just; Blanchard, Julia L; Brock, Daniel J; Clark, Graeme F; Cooper, Antonia T; Davis, Tom R; Day, Paul B; Duffy, J Emmett; Holmes, Thomas H; Howe, Steffan A; Jordan, Alan; Kininmonth, Stuart; Knott, Nathan A; Lefcheck, Jonathan S; Ling, Scott D; Parr, Amanda; Strain, Elisabeth; Sweatman, Hugh; Thomson, Russell

2017-02-01

Reporting progress against targets for international biodiversity agreements is hindered by a shortage of suitable biodiversity data. We describe a cost-effective system involving Reef Life Survey citizen scientists in the systematic collection of quantitative data covering multiple phyla that can underpin numerous marine biodiversity indicators at high spatial and temporal resolution. We then summarize the findings of a continental- and decadal-scale State of the Environment assessment for rocky and coral reefs based on indicators of ecosystem state relating to fishing, ocean warming, and invasive species and describing the distribution of threatened species. Fishing impacts are widespread, whereas substantial warming-related change affected some regions between 2005 and 2015. Invasive species are concentrated near harbors in southeastern Australia, and the threatened-species index is highest for the Great Australian Bight and Tasman Sea. Our approach can be applied globally to improve reporting against biodiversity targets and enhance public and policymakers' understanding of marine biodiversity trends.

Advancing Early Childhood Development: from Science to Scale 1

PubMed Central

Black, Maureen M; Walker, Susan P; Fernald, Lia C H; Andersen, Christopher T; DiGirolamo, Ann M; Lu, Chunling; McCoy, Dana C; Fink, Günther; Shawar, Yusra R; Shiffman, Prof Jeremy; Devercelli, Amanda E; Wodon, Quentin T; Vargas-Barón, Emily; Grantham-McGregor, Sally

2018-01-01

Early childhood development programmes vary in coordination and quality, with inadequate and inequitable access, especially for children younger than 3 years. New estimates, based on proxy measures of stunting and poverty, indicate that 250 million children (43%) younger than 5 years in low-income and middle-income countries are at risk of not reaching their developmental potential. There is therefore an urgent need to increase multisectoral coverage of quality programming that incorporates health, nutrition, security and safety, responsive caregiving, and early learning. Equitable early childhood policies and programmes are crucial for meeting Sustainable Development Goals, and for children to develop the intellectual skills, creativity, and wellbeing required to become healthy and productive adults. In this paper, the first in a three part Series on early childhood development, we examine recent scientific progress and global commitments to early childhood development. Research, programmes, and policies have advanced substantially since 2000, with new neuroscientific evidence linking early adversity and nurturing care with brain development and function throughout the life course. PMID:27717614

Assessing National Biodiversity Trends for Rocky and Coral Reefs through the Integration of Citizen Science and Scientific Monitoring Programs

PubMed Central

Stuart-Smith, Rick D.; Edgar, Graham J.; Barrett, Neville S.; Bates, Amanda E.; Baker, Susan C.; Bax, Nicholas J.; Becerro, Mikel A.; Berkhout, Just; Blanchard, Julia L.; Brock, Daniel J.; Clark, Graeme F.; Cooper, Antonia T.; Davis, Tom R.; Day, Paul B.; Duffy, J. Emmett; Holmes, Thomas H.; Howe, Steffan A.; Jordan, Alan; Kininmonth, Stuart; Knott, Nathan A.; Lefcheck, Jonathan S.; Ling, Scott D.; Parr, Amanda; Strain, Elisabeth; Sweatman, Hugh; Thomson, Russell

2017-01-01

Abstract Reporting progress against targets for international biodiversity agreements is hindered by a shortage of suitable biodiversity data. We describe a cost-effective system involving Reef Life Survey citizen scientists in the systematic collection of quantitative data covering multiple phyla that can underpin numerous marine biodiversity indicators at high spatial and temporal resolution. We then summarize the findings of a continental- and decadal-scale State of the Environment assessment for rocky and coral reefs based on indicators of ecosystem state relating to fishing, ocean warming, and invasive species and describing the distribution of threatened species. Fishing impacts are widespread, whereas substantial warming-related change affected some regions between 2005 and 2015. Invasive species are concentrated near harbors in southeastern Australia, and the threatened-species index is highest for the Great Australian Bight and Tasman Sea. Our approach can be applied globally to improve reporting against biodiversity targets and enhance public and policymakers’ understanding of marine biodiversity trends. PMID:28596615

Compendium of meteorology scientific issues of 1950 still outstanding

NASA Technical Reports Server (NTRS)

Vaughan, W. W.

1986-01-01

The Compendium of Meteorology was published in 1951 by the American Meteorological Society. A review was made of the Compendium of Meteorology to identify the studies and future needs which the authors expressed in their papers. The needs as seen by the authors are organized into sections and papers following the format of the Compendium of Meteorology. In some cases the needs they identified are as valid today as they were in 1951. In other cases one will easily be able to identify examples where significant progress has been made. It is left to the individual scientists and scientific program managers to assess whether significant progress has been made over the past thirty-five years on these outstanding scientific issues.

How should novelty be valued in science?

PubMed

Cohen, Barak A

2017-07-25

Scientists are under increasing pressure to do "novel" research. Here I explore whether there are risks to overemphasizing novelty when deciding what constitutes good science. I review studies from the philosophy of science to help understand how important an explicit emphasis on novelty might be for scientific progress. I also review studies from the sociology of science to anticipate how emphasizing novelty might impact the structure and function of the scientific community. I conclude that placing too much value on novelty could have counterproductive effects on both the rate of progress in science and the organization of the scientific community. I finish by recommending that our current emphasis on novelty be replaced by a renewed emphasis on predictive power as a characteristic of good science.

31 CFR 341.8 - Payment or redemption during lifetime of owner.

Code of Federal Regulations, 2012 CFR

2012-07-01

... progressive. (5) Damage to the brain or brain abnormality which has resulted in severe loss of judgment... substantial, gainful activity: (1) Loss of use of two limbs. (2) Certain progressive diseases which have...

31 CFR 341.8 - Payment or redemption during lifetime of owner.

Code of Federal Regulations, 2011 CFR

2011-07-01

... progressive. (5) Damage to the brain or brain abnormality which has resulted in severe loss of judgment... substantial, gainful activity: (1) Loss of use of two limbs. (2) Certain progressive diseases which have...

31 CFR 341.8 - Payment or redemption during lifetime of owner.

Code of Federal Regulations, 2013 CFR

2013-07-01

... progressive. (5) Damage to the brain or brain abnormality which has resulted in severe loss of judgment... substantial, gainful activity: (1) Loss of use of two limbs. (2) Certain progressive diseases which have...

Scientific Discovery through Advanced Computing in Plasma Science

NASA Astrophysics Data System (ADS)

Tang, William

2005-03-01

Advanced computing is generally recognized to be an increasingly vital tool for accelerating progress in scientific research during the 21st Century. For example, the Department of Energy's ``Scientific Discovery through Advanced Computing'' (SciDAC) Program was motivated in large measure by the fact that formidable scientific challenges in its research portfolio could best be addressed by utilizing the combination of the rapid advances in super-computing technology together with the emergence of effective new algorithms and computational methodologies. The imperative is to translate such progress into corresponding increases in the performance of the scientific codes used to model complex physical systems such as those encountered in high temperature plasma research. If properly validated against experimental measurements and analytic benchmarks, these codes can provide reliable predictive capability for the behavior of a broad range of complex natural and engineered systems. This talk reviews recent progress and future directions for advanced simulations with some illustrative examples taken from the plasma science applications area. Significant recent progress has been made in both particle and fluid simulations of fine-scale turbulence and large-scale dynamics, giving increasingly good agreement between experimental observations and computational modeling. This was made possible by the combination of access to powerful new computational resources together with innovative advances in analytic and computational methods for developing reduced descriptions of physics phenomena spanning a huge range in time and space scales. In particular, the plasma science community has made excellent progress in developing advanced codes for which computer run-time and problem size scale well with the number of processors on massively parallel machines (MPP's). A good example is the effective usage of the full power of multi-teraflop (multi-trillion floating point computations per second) MPP's to produce three-dimensional, general geometry, nonlinear particle simulations which have accelerated progress in understanding the nature of plasma turbulence in magnetically-confined high temperature plasmas. These calculations, which typically utilized billions of particles for thousands of time-steps, would not have been possible without access to powerful present generation MPP computers and the associated diagnostic and visualization capabilities. In general, results from advanced simulations provide great encouragement for being able to include increasingly realistic dynamics to enable deeper physics insights into plasmas in both natural and laboratory environments. The associated scientific excitement should serve to stimulate improved cross-cutting collaborations with other fields and also to help attract bright young talent to the computational science area.

Spatial Thinking as the Dimension of Progress in an Astronomy Learning Progression

ERIC Educational Resources Information Center

Plummer, Julia D.

2014-01-01

The big idea of "celestial motion", observational astronomy phenomena explained by the relative position and motion of objects in the solar system and beyond, is central to astronomy in primary and secondary education. In this paper, I argue that students' progress in developing productive, scientific explanations for this class of…

Strengthening Scientific Verbal Behavior: An Experimental Comparison of Progressively Prompted and Unprompted Programmed Instruction and Prose Tutorials

ERIC Educational Resources Information Center

Davis, Darrel R.; Bostow, Darrel E.; Heimisson, Gudmundur T.

2007-01-01

Web-based software was used to deliver and record the effects of programmed instruction that progressively added formal prompts until attempts were successful, programmed instruction with one attempt, and prose tutorials. Error-contingent progressive prompting took significantly longer than programmed instruction and prose. Both forms of…

The Development and Validation of a Learning Progression for Argumentation in Science

ERIC Educational Resources Information Center

Osborne, Jonathan F.; Henderson, J. Bryan; MacPherson, Anna; Szu, Evan; Wild, Andrew; Yao, Shi-Ying

2016-01-01

Given the centrality of argumentation in the Next Generation Science Standards, there is an urgent need for an empirically validated learning progression of this core practice and the development of high-quality assessment items. Here, we introduce a hypothesized three-tiered learning progression for scientific argumentation. The learning…

Policy-driven development of cost-effective, risk-based surveillance strategies.

PubMed

Reist, M; Jemmi, T; Stärk, K D C

2012-07-01

Animal health and residue surveillance verifies the good health status of the animal population, thereby supporting international free trade of animals and animal products. However, active surveillance is costly and time-consuming. The development of cost-effective tools for animal health and food hazard surveillance is therefore a priority for decision-makers in the field of veterinary public health. The assumption of this paper is that outcome-based formulation of standards, legislation leaving room for risk-based approaches and close collaboration and a mutual understanding and exchange between scientists and policy makers are essential for cost-effective surveillance. We illustrate this using the following examples: (i) a risk-based sample size calculation for surveys to substantiate freedom from diseases/infection, (ii) a cost-effective national surveillance system for Bluetongue using scenario tree modelling and (iii) a framework for risk-based residue monitoring. Surveys to substantiate freedom from infectious bovine rhinotracheitis and enzootic bovine leucosis between 2002 and 2009 saved over 6 million € by applying a risk-based sample size calculation approach, and by taking into account prior information from repeated surveys. An open, progressive policy making process stimulates research and science to develop risk-based and cost-efficient survey methodologies. Early involvement of policy makers in scientific developments facilitates implementation of new findings and full exploitation of benefits for producers and consumers. Copyright © 2012 Elsevier B.V. All rights reserved.

Quotation accuracy in medical journal articles-a systematic review and meta-analysis.

PubMed

Jergas, Hannah; Baethge, Christopher

2015-01-01

Background. Quotations and references are an indispensable element of scientific communication. They should support what authors claim or provide important background information for readers. Studies indicate, however, that quotations not serving their purpose-quotation errors-may be prevalent. Methods. We carried out a systematic review, meta-analysis and meta-regression of quotation errors, taking account of differences between studies in error ascertainment. Results. Out of 559 studies screened we included 28 in the main analysis, and estimated major, minor and total quotation error rates of 11,9%, 95% CI [8.4, 16.6] 11.5% [8.3, 15.7], and 25.4% [19.5, 32.4]. While heterogeneity was substantial, even the lowest estimate of total quotation errors was considerable (6.7%). Indirect references accounted for less than one sixth of all quotation problems. The findings remained robust in a number of sensitivity and subgroup analyses (including risk of bias analysis) and in meta-regression. There was no indication of publication bias. Conclusions. Readers of medical journal articles should be aware of the fact that quotation errors are common. Measures against quotation errors include spot checks by editors and reviewers, correct placement of citations in the text, and declarations by authors that they have checked cited material. Future research should elucidate if and to what degree quotation errors are detrimental to scientific progress.

Quotation accuracy in medical journal articles—a systematic review and meta-analysis

PubMed Central

Jergas, Hannah

2015-01-01

Background. Quotations and references are an indispensable element of scientific communication. They should support what authors claim or provide important background information for readers. Studies indicate, however, that quotations not serving their purpose—quotation errors—may be prevalent. Methods. We carried out a systematic review, meta-analysis and meta-regression of quotation errors, taking account of differences between studies in error ascertainment. Results. Out of 559 studies screened we included 28 in the main analysis, and estimated major, minor and total quotation error rates of 11,9%, 95% CI [8.4, 16.6] 11.5% [8.3, 15.7], and 25.4% [19.5, 32.4]. While heterogeneity was substantial, even the lowest estimate of total quotation errors was considerable (6.7%). Indirect references accounted for less than one sixth of all quotation problems. The findings remained robust in a number of sensitivity and subgroup analyses (including risk of bias analysis) and in meta-regression. There was no indication of publication bias. Conclusions. Readers of medical journal articles should be aware of the fact that quotation errors are common. Measures against quotation errors include spot checks by editors and reviewers, correct placement of citations in the text, and declarations by authors that they have checked cited material. Future research should elucidate if and to what degree quotation errors are detrimental to scientific progress. PMID:26528420

Nutritional and safety assessment of foods and feeds nutritionally improved through biotechnology--case studies by the International Food Biotechnology Committee of ILSI.

PubMed

Glenn, Kevin C

2008-01-01

During the last two decades, the public and private sectors have made substantial research progress internationally toward improving the nutritional value of a wide range of food and feed crops. Nevertheless, significant numbers of people still suffer from the effects of undernutrition. As newly developed crops with nutritionally improved traits come closer to being available to producers and consumers, scientifically sound and efficient processes are needed to assess the safety and nutritional quality of these crops. In 2004, a Task Force of international scientific experts, convened by the International Food Biotechnology Committee (IFBiC) of ILSI, published recommendations for the safety and nutritional assessment of foods and feeds nutritionally improved through modern biotechnology (J. Food Science, 2004, 69:CRH62-CRH68). The comparative safety assessment process is a basic principle in this publication and is the starting point, not the conclusion, of the analysis. Significant differences in composition are expected to be observed in the case of nutritionally enhanced crops and must be assessed on a case-by-case basis. The Golden Rice 2 case study will be presented as an example of a food crop nutritionally enhanced through the application of modern biotechnology (i.e., recombinant DNA techniques) to illustrate how the 2004 recommendations provide a robust paradigm for the safety assessment of "real world" examples of improved nutrition crops.

Intraobserver and Interobserver Agreement of Structural and Functional Software Programs for Measuring Glaucoma Progression.

PubMed

Moreno-Montañés, Javier; Antón, Vanesa; Antón, Alfonso; Larrosa, José M; Martinez-de-la-Casa, José María; Rebolleda, Gema; Ussa, Fernando; García-Granero, Marta

2017-04-01

It is important to evaluate intraobserver and interobserver agreement using visual field (VF) testing and optical coherence tomography (OCT) software in order to understand whether the use of this software is sufficient to detect glaucoma progression and to make decisions regarding its treatment. To evaluate agreement in VF and OCT software among 5 glaucoma specialists. The printout pages from VF progression software and OCT progression software from 100 patients were randomized, and the 5 glaucoma specialists subjectively and independently evaluated them for glaucoma. Each image was classified as having no progression, questionable progression, or progression. The principal investigator classified the patients previously as without variability (normal) or with high variability among tests (difficult). Using both software, the specialists also evaluated whether the glaucoma damage had progressed and if treatment change was needed. One month later, the same observers reevaluated the patients in a different order to determine intraobserver reproducibility. Intraobserver and interobserver agreement was estimated using κ statistics and Gwet second-order agreement coefficient. The agreement was compared with other factors. Of the 100 observed patients, half were male and all were white; the mean (SD) age was 69.7 (14.1) years. Intraobserver agreement was substantial to almost perfect for VF software (overall κ [95% CI], 0.59 [0.46-0.72] to 0.87 [0.79-0.96]) and similar for OCT software (overall κ [95% CI], 0.59 [0.46-0.71] to 0.85 [0.76-0.94]). Interobserver agreement among the 5 glaucoma specialists with the VF progression software was moderate (κ, 0.48; 95% CI, 0.41-0.55) and similar to OCT progression software (κ, 0.52; 95% CI, 0.44-0.59). Interobserver agreement was substantial in images classified as having no progression but only fair in those classified as having questionable glaucoma progression or glaucoma progression. Interobserver agreement was fair regarding questions about glaucoma progression (κ, 0.39; 95% CI, 0.32-0.48) and consideration about treatment changes (κ, 0.39; 95% CI, 0.32-0.48). The factors associated with agreement were the glaucoma stage and case difficulty. There was substantial intraobserver agreement but moderate interobserver agreement among glaucoma specialists using 2 glaucoma progression software packages. These data suggest that these glaucoma progression software packages are insufficient to obtain high interobserver agreement in both devices except in patients with no progression. The low agreement regarding progression or treatment changes suggests that both software programs used in isolation are insufficient for decision making.

English Language Publishing in Chemical Engineering Journals from an Indian Academic's Point of View--A Broad Scientific Perspective

ERIC Educational Resources Information Center

Palit, Sukanchan

2016-01-01

Scientific vision and scientific understanding in today's world are in the path of new glory. Chemical Engineering science is witnessing drastic and rapid changes. The metamorphosis of human civilization in this century is faced with vicious challenges. Progress of Chemical Engineering science, the vision of technology and the broad chemical…

On the gender-science stereotypes held by scientists: explicit accord with gender-ratios, implicit accord with scientific identity.

PubMed

Smyth, Frederick L; Nosek, Brian A

2015-01-01

Women's representation in science has changed substantially, but unevenly, over the past 40 years. In health and biological sciences, for example, women's representation among U.S. scientists is now on par with or greater than men's, while in physical sciences and engineering they remain a clear minority. We investigated whether variation in proportions of women in scientific disciplines is related to differing levels of male-favoring explicit or implicit stereotypes held by students and scientists in each discipline. We hypothesized that science-is-male stereotypes would be weaker in disciplines where women are better represented. This prediction was tested with a sample of 176,935 college-educated participants (70% female), including thousands of engineers, physicians, and scientists. The prediction was supported for the explicit stereotype, but not for the implicit stereotype. Implicit stereotype strength did not correspond with disciplines' gender ratios, but, rather, correlated with two indicators of disciplines' scientific intensity, positively for men and negatively for women. From age 18 on, women who majored or worked in disciplines perceived as more scientific had substantially weaker science-is-male stereotypes than did men in the same disciplines, with gender differences larger than 0.8 standard deviations in the most scientifically-perceived disciplines. Further, particularly for women, differences in the strength of implicit stereotypes across scientific disciplines corresponded with the strength of scientific values held by women in the disciplines. These results are discussed in the context of dual process theory of mental operation and balanced identity theory. The findings point to the need for longitudinal study of the factors' affecting development of adults' and, especially, children's implicit gender stereotypes and scientific identity.

On the gender–science stereotypes held by scientists: explicit accord with gender-ratios, implicit accord with scientific identity

PubMed Central

Smyth, Frederick L.; Nosek, Brian A.

2015-01-01

Women's representation in science has changed substantially, but unevenly, over the past 40 years. In health and biological sciences, for example, women's representation among U.S. scientists is now on par with or greater than men's, while in physical sciences and engineering they remain a clear minority. We investigated whether variation in proportions of women in scientific disciplines is related to differing levels of male-favoring explicit or implicit stereotypes held by students and scientists in each discipline. We hypothesized that science-is-male stereotypes would be weaker in disciplines where women are better represented. This prediction was tested with a sample of 176,935 college-educated participants (70% female), including thousands of engineers, physicians, and scientists. The prediction was supported for the explicit stereotype, but not for the implicit stereotype. Implicit stereotype strength did not correspond with disciplines' gender ratios, but, rather, correlated with two indicators of disciplines' scientific intensity, positively for men and negatively for women. From age 18 on, women who majored or worked in disciplines perceived as more scientific had substantially weaker science-is-male stereotypes than did men in the same disciplines, with gender differences larger than 0.8 standard deviations in the most scientifically-perceived disciplines. Further, particularly for women, differences in the strength of implicit stereotypes across scientific disciplines corresponded with the strength of scientific values held by women in the disciplines. These results are discussed in the context of dual process theory of mental operation and balanced identity theory. The findings point to the need for longitudinal study of the factors' affecting development of adults' and, especially, children's implicit gender stereotypes and scientific identity. PMID:25964765

Field station as stage: Re-enacting scientific work and life in Amani, Tanzania.

PubMed

Geissler, P Wenzel; Kelly, Ann H

2016-12-01

Located high in Tanzania's Usambara Mountains, Amani Hill Station has been a site of progressive scientific endeavours for over a century, pushing the boundaries of botanical, zoological and medical knowledge, and providing expertise for imperial expansion, colonial welfare, national progress and international development efforts. The station's heyday was from the 1950s to the 1970s, a period of global disease eradication campaigns and the 'Africanization' of science. Today, Amani lies in a state of suspended motion. Officially part of a national network of medical research stations, its buildings and vegetation are only minimally maintained, and although some staff report for duty, scientific work has ceased. Neither ruin nor time capsule, Amani has become a quiet site of remains and material traces. This article examines the methodological potentials of re-enactment - on-site performances of past research practices - to engage ethnographically with the distinct temporalities and affective registers of life at the station. The heuristic power of re-enactment resides in its anachronicity, the tensions it introduces between immediacy and theatricality, authenticity and artifice, fidelity and futility. We suggest that re-enacting early post-colonial science as events unfolding in the present disrupts straightforward narratives about the promises and shortfalls of scientific progress, raising provocative questions about the sentiments and stakes of research in 'the tropics'.

76 FR 32911 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Striped...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... Endangered Wildlife and Plants that contains substantial scientific or commercial information that listing a...-0007; MO 92210-0-0008 B2] Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition... Endangered Species Act of 1973, as amended (Act). After review of all available scientific and commercial...

An Analysis of the Relationship between Information and Communication Technology (ICT) and Scientific Literacy in Canada and Australia

ERIC Educational Resources Information Center

Luu, King; Freeman, John G.

2011-01-01

Despite the lack of substantial evidence for improvement in the quality of teaching and learning with information and communication technology (ICT), governmental organizations have pushed ICT as a means of providing broad-scale training to meet the demand for a skilled workforce, centred upon a hypothesized ICT-scientific literacy relationship.…

Problems of Scientific Research Activity in Institutions of Higher Learning

ERIC Educational Resources Information Center

Solodnikov, V. V.

2008-01-01

Under current conditions, the role played by scientific knowledge in all spheres of public life is rising substantially, and more and more attention is being paid to problems of the development and modernization of the Academy of Sciences. Not long ago, for example, there was wide response to the findings of a special study by S. Belanovskii on…

Developing a Learning Progression for Three-Dimensional Learning of the Patterns of Evolution

ERIC Educational Resources Information Center

Wyner, Yael; Doherty, Jennifer H.

2017-01-01

This paper examines how students make progress toward three-dimensional (3D) understanding of the patterns of evolution. Specifically, it proposes a learning progression that explains how scientific practices, crosscutting concepts, and disciplinary core ideas come together in naming and grouping, length of change over time, and the role of common…

Cleaner Air through Cooperation: Progress under the Air Quality Agreement- 2003

EPA Pesticide Factsheets

Read a brochure that provides an overview of the air quality agreement between the U.S. and Canada, followed by key commitments and progress, including air quality programs and scientific cooperation between the two nations.

Regulatory framework in assisted reproductive technologies, relevance and main issues.

PubMed

Merlet, Françoise

2009-01-01

Assisted reproductive technologies (ART) have changed life for the past 25 years and many ethical and social issues have emerged following this new method of conception. In order to protect individuals against scientific and ethical abuses without inhibiting scientific progress, a specific legal framework is necessary. The first French law on Bioethics was voted after an extensive debate in 1994 then reviewed in 2004. This review previously scheduled every five years is currently being discussed. Legal provisions applying to ART are part of a large framework including the protection of the patients' rights and biomedical research. The key principles consist of respect for human life and ban on commercial practices of human body parts, eugenic practices and any kind of cloning. These key principles apply to ART. Donation is anonymous and free. Created in 2004, the Agence de la biomédecine is a government agency and one of the main tools of the French regulations. The missions focus on improving the quality and the safety of the management of ART. Evaluation of activities is available to all from the annual report. The agency represents the French competent authority for medical and scientific aspects of ART. Substantial differences in European legislations exist from the open-up "laissez faire" to the most restrictive one. As a consequence a large reproductive tourism has developed particularly for egg donation or surrogacy. The medical and ethical conditions of management of patients and donors represent the main critical points. In order to avoid ethical abuses, homogenization regarding the key principles is necessary in Europe. It is an opportunity to reassert that human body parts should not be a source of financial gain.

Orbital Observatory for Planetary Science on Low Cost Autonomous Platform

NASA Astrophysics Data System (ADS)

Tavrov, Alexander; Bisikalo, Dmitry; Vedenkin, Nikolay; Korablev, Oleg; Markov, Alexander; Kiselev, Alexander; Kokorich, Mikhail

The Space Research Institute of Russian Academy of Science (IKI RAS) and Dauria Aerospace are currently developing the middle class space telescope project aiming to observe Solar system planets by a long term spectroscopy and polarimetry monitoring, as well aiming to extra solar planets (exoplanets) engineering and scientific goals. The spacecraft is scheduled to be launched in 2017. It is planned first to be delivered on board of the ISS by the Progress spacecraft, then it will be released to the desired orbit approx. 550 km by the Progress in the way to its final destination. The “Planetary monitoring” telescope has a 0.6 meter primary mirror diameter Telescope currently includes 5 science instruments: NIR: 1000..4000 nm high-resolution spectrometer with the spectral resolution of R>10000; Visible Field camera with filters wheel; UV-VIS field resolved Fourier spectrometer; UV-VIS spectropolarimeter; Stellar coronagraph linked with a low-resolution spectrometer. The scientific goals of the “Planetary monitoring” telescope are devoted to explore not yet well studied questions on Mars (methane, ozone, dust and clouds, isotope ratio of HDO/H2O), on Venus (UV absorber, night glow, atmosphere dynamics), icy and gaseous Solar system planets, Jovian moons, Lunar exosphere, comets, meteorites. This telescope aims also for engineering development of exoplanet study by stellar coronagraphy linked with a low-resolution spectrometry. This Orbital Observatory mission uses the first low cost small satellite platform developed by the Dauria Aerospace® - Russian private company and reuses the Progress to elevate the observatory orbit. The Progress launches four times per year to provide supplies and scientific instruments to the ISS. The Progress is capable of raising the height of the orbit for the piggyback scientific missions; therefore, the implementation of the Orbital Observatory mission is considered not just as a development of a successful science mission so it is most importantly developing an affordable and frequent flight opportunities for space sciences research in Russia and worldwide. The paper describes the scientific objectives and corresponding instruments, and introduces the low cost satellite platform and launch opportunities.

Using learning networks to understand complex systems: a case study of biological, geophysical and social research in the Amazon.

PubMed

Barlow, Jos; Ewers, Robert M; Anderson, Liana; Aragao, Luiz E O C; Baker, Tim R; Boyd, Emily; Feldpausch, Ted R; Gloor, Emanuel; Hall, Anthony; Malhi, Yadvinder; Milliken, William; Mulligan, Mark; Parry, Luke; Pennington, Toby; Peres, Carlos A; Phillips, Oliver L; Roman-Cuesta, Rosa Maria; Tobias, Joseph A; Gardner, Toby A

2011-05-01

Developing high-quality scientific research will be most effective if research communities with diverse skills and interests are able to share information and knowledge, are aware of the major challenges across disciplines, and can exploit economies of scale to provide robust answers and better inform policy. We evaluate opportunities and challenges facing the development of a more interactive research environment by developing an interdisciplinary synthesis of research on a single geographic region. We focus on the Amazon as it is of enormous regional and global environmental importance and faces a highly uncertain future. To take stock of existing knowledge and provide a framework for analysis we present a set of mini-reviews from fourteen different areas of research, encompassing taxonomy, biodiversity, biogeography, vegetation dynamics, landscape ecology, earth-atmosphere interactions, ecosystem processes, fire, deforestation dynamics, hydrology, hunting, conservation planning, livelihoods, and payments for ecosystem services. Each review highlights the current state of knowledge and identifies research priorities, including major challenges and opportunities. We show that while substantial progress is being made across many areas of scientific research, our understanding of specific issues is often dependent on knowledge from other disciplines. Accelerating the acquisition of reliable and contextualized knowledge about the fate of complex pristine and modified ecosystems is partly dependent on our ability to exploit economies of scale in shared resources and technical expertise, recognise and make explicit interconnections and feedbacks among sub-disciplines, increase the temporal and spatial scale of existing studies, and improve the dissemination of scientific findings to policy makers and society at large. Enhancing interaction among research efforts is vital if we are to make the most of limited funds and overcome the challenges posed by addressing large-scale interdisciplinary questions. Bringing together a diverse scientific community with a single geographic focus can help increase awareness of research questions both within and among disciplines, and reveal the opportunities that may exist for advancing acquisition of reliable knowledge. This approach could be useful for a variety of globally important scientific questions. © 2010 The Authors. Biological Reviews © 2010 Cambridge Philosophical Society.

Statistical characteristics of breakthrough discoveries in science using the metaphor of black and white swans

NASA Astrophysics Data System (ADS)

Zeng, Carl J.; Qi, Eric P.; Li, Simon S.; Stanley, H. Eugene; Ye, Fred Y.

2017-12-01

A publication that reports a breakthrough discovery in a particular scientific field is referred to as a ;black swan;, and the most highly-cited papers previously published in the same field ;white swans;. Important scientific progress occurs when ;white swans; meet a ;black swan;, and the citation patterns of the ;white swans; change. This metaphor combines scientific discoveries and scientometric data and suggests that breakthrough scientific discoveries are either ;black swans; or ;grey-black swans;.

ESMC

ScienceCinema

None

2018-05-25

2 days of workshops at CERN. Part 1: Scientific communication: many speeches followed by questions and intense discussions: 1. François de Closet "Scientific Progress", 2. Gerhard Moosleiter, 3. H. Meyers "How to create better conditions for scientific communication". Part 2: Science and Communication. A Russian from Moscow speaks about, among other things, the current situation of the scientific press in Russia. Part 3: Conclusions and reports from the day before from different work groups. Part 4: Questions with C. Rubbia and N. Calder and thanks are given.

The Need for More Earthquake Science in Southeast Asia

NASA Astrophysics Data System (ADS)

Sieh, K.

2015-12-01

Many regions within SE Asia have as great a density of active seismic structures as does the western US - Sumatra, Myanmar, Bangladesh, New Guinea and the Philippines come first to mind. Much of Earth's release of seismic energy in the current millennium has, in fact, come from these regions, with great losses of life and livelihoods. Unfortunately, the scientific progress upon which seismic-risk reduction in SE Asia ultimately depends has been and continues to be slow. Last year at AGU, for example, I counted 57 talks about the M6 Napa earthquake. In contrast, I can't recall hearing any talk on a SE Asian M6 earthquake at any venue in the past many years. In fact, even M7+ earthquakes often go unstudied. Not uncommonly, the region's earthquake scientists face high financial and political impediments to conducting earthquake research. Their slow speed in the development of scientific knowledge doesn't bode well for speedy progress in the science of seismic hazards, the sine qua non for substantially reducing seismic risk. There are two basic necessities for the region to evolve significantly from the current state of affairs. Both involve the development of regional infrastructure: 1) Data: Robust and accessible geophysical monitoring systems would need to be installed, maintained and utilized by the region's earth scientists and their results shared internationally. Concomitantly, geological mapping (sensu lato) would need to be undertaken. 2) People: The training, employment, and enduring support of a new, young, international corps of earth scientists would need to accelerate markedly. The United States could play an important role in achieving the goal of significant seismic risk reduction in the most seismically active countries of SE Asia by taking the lead in establishing a coalition to robustly fund a multi-decadal program that supports scientists and their research institutions to work alongside local expertise.

South-south collaboration on HIV/AIDS prevention and treatment research: when birds of a feather rarely flock together.

PubMed

Fonseca, Bruna de Paula Fonseca E; Albuquerque, Priscila Costa; Noyons, Ed; Zicker, Fabio

2018-03-01

South-south collaboration on health and development research is a critical mechanism for social and economic progress. It allows sharing and replicating experiences to find a "southern solution" to meet shared health challenges, such as access to adequate HIV/AIDS prevention and treatment. This study aimed to generate evidence on the dynamics of south-south collaboration in HIV/AIDS research, which could ultimately inform stakeholders on the progress and nature of collaboration towards increased research capacities in low- and middle-income countries (LMIC). Bibliometric and social network analysis methods were used to assess the 10-year (2006-2015) scientific contribution of LMIC, through the analysis of scientific publications on HIV/AIDS prevention and/or treatment. Five dimensions oriented the study: knowledge production, co-authorship analysis, research themes mapping, research types classification and funding sources. Publications involving LMIC have substantially increased overtime, despite small expression of south-south collaboration. Research themes mapping revealed that publication focus varied according to collaborating countries' income categories, from diagnosis, opportunistic infections and laboratory-based research (LMIC single or LMIC-LMIC) to human behavior and healthcare, drug therapy and mother to child transmission (LMIC-HIC). The analysis of research types showed that south-south collaborations frequently targeted social sciences issues. Funding agencies acknowledged in south-south collaboration also showed diverse focus: LMIC-based funders tended to support basic biomedical research whereas international/HIC-based funders seem to cover predominantly social sciences-oriented research. Although the global environment has fostered an increasing participation of LMIC in collaborative learning models, south-south collaboration on HIV/AIDS prevention and/or treatment research seemed to be lower than expected, stressing the need for strategies to foster these partnerships. The evidence presented in this study can be used to strengthen a knowledge platform to inform future policy, planning and funding decisions, contributing to the development of enhanced collaboration and a priority research agenda for LMICs.

Direct probing of chromatography columns by laser-induced fluorescence

NASA Astrophysics Data System (ADS)

McGuffin, V. L.

1992-12-01

This report summarizes the progress and accomplishments of this research project from 1 Sep. 1989 to 28 Feb. 1993. During this period, we have accomplished all of the primary scientific objectives of the research proposal: (1) constructed and evaluated a laser-induced fluorescence detection system that allows direct examination of the chromatographic column, (2) examined nonequilibrium processes that occur upon solute injection and elution, (3) examined solute retention in liquid chromatography as a function of temperature and pressure, (4) examined solute zone dispersion in liquid chromatography as a function of temperature and pressure, and (5) developed appropriate theoretical models to describe these phenomena. In each of these studies, substantial knowledge has been gained of the fundamental processes that are responsible for chromatographic separations. In addition to these primary research objectives, we have made significant progress in three related areas: (1) examined pyrene as a fluorescent polarity probe in supercritical fluids and liquids as a function of temperature and pressure, (2) developed methods for the class-selective identification of polynuclear aromatic hydrocarbons in coal-derived fluids by microcolumn liquid chromatography with fluorescence quenching detection, and (3) developed methods for the determination of saturated and unsaturated (including omega-3) fatty acids in fish oil extracts by microcolumn liquid chromatography with laser-induced fluorescence detection. In these studies, the advanced separation and detection techniques developed in our laboratory are applied to practical problems of environmental and biomedical significance.

Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials.

PubMed

Carter, Gregory T; Abood, Mary E; Aggarwal, Sunil K; Weiss, Michael D

2010-08-01

Significant advances have increased our understanding of the molecular mechanisms of amyotrophic lateral sclerosis (ALS), yet this has not translated into any greatly effective therapies. It appears that a number of abnormal physiological processes occur simultaneously in this devastating disease. Ideally, a multidrug regimen, including glutamate antagonists, antioxidants, a centrally acting anti-inflammatory agent, microglial cell modulators (including tumor necrosis factor alpha [TNF-alpha] inhibitors), an antiapoptotic agent, 1 or more neurotrophic growth factors, and a mitochondrial function-enhancing agent would be required to comprehensively address the known pathophysiology of ALS. Remarkably, cannabis appears to have activity in all of those areas. Preclinical data indicate that cannabis has powerful antioxidative, anti-inflammatory, and neuroprotective effects. In the G93A-SOD1 ALS mouse, this has translated to prolonged neuronal cell survival, delayed onset, and slower progression of the disease. Cannabis also has properties applicable to symptom management of ALS, including analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction. With respect to the treatment of ALS, from both a disease modifying and symptom management viewpoint, clinical trials with cannabis are the next logical step. Based on the currently available scientific data, it is reasonable to think that cannabis might significantly slow the progression of ALS, potentially extending life expectancy and substantially reducing the overall burden of the disease.

78 FR 24750 - Scientific Information Request Therapies for Clinically Localized Prostate Cancer

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

... and benefits of the following therapies for clinically localized prostate cancer? a. Radical... prostate cancer: radical prostatectomy (including retropubic, perineal, laparoscopic, robotic-assisted..., biochemical (PSA) progression, metastatic and/or clinical progression-free survival, health status, and...

78 FR 44136 - Submission for OMB review; 30-day Comment Request: National Cancer Institute (NCI) Cancer...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-23

...; 30-day Comment Request: National Cancer Institute (NCI) Cancer Nanotechnology Platform Partnership...: Dorothy Farrell, Center for Strategic Scientific Initiatives, Office of Cancer Nanotechnology Research... Cancer Institute (NCI) Alliance for Nanotechnology in Cancer Platform Partnership Scientific Progress...

Final Scientific Report: DE-SC0008580

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seidler, Gerald T.

We report scientific, technical, and organizational accomplishments under DE-SC0008580. This includes 10 publications, 5 patent or provisional patent applications, beamtime with important results at both LCLS and APS, and new progress in understanding target design for x-ray heating experiments at x-ray heating facilities.

Division A Commission 31: Time

NASA Astrophysics Data System (ADS)

Hosokawa, Mizuhiko; Arias, Elisa Felicitas; Manchester, Richard; Tuckey, Philip; Matsakis, Demetrios; Zhang, Shougang; Zharov, Vladimir

2016-04-01

Time is an essential element of fundamental astronomy. In recent years there have been many time-related issues, in scientific and technological aspects as well as in conventions and definitions. At the Commission 31 (Time) business meeting at the XXIX General Assembly, recent progress and many topics, including Pulsar Time Scales WG and Future UTC WG activities, were reviewed and discussed. In this report, we will review the progress of these topics in the past three years. There are many remarkable topics, such as Time scales, Atomic clock development, Time transfer, Future UTC and future redefinition of the second. Among them, scientific highlights are the progress of pulsar time scales and the optical frequency standards. On the other hand, as the social convention, change in the definition of UTC and the second is important.

De la science à l'éthique, et retour

NASA Astrophysics Data System (ADS)

Besnier, J.

For ages, the progress of knowledge and the progress of humanity were considered as being associated. We now must take the consequences of the dislocation between moral code and science, and attempt to build an "ethics of knowledge" (J. Monod), despite the flow back of ideals built up by the Enlightment and a loss of trust in the progress. But how can one conceive an ethics of scientific research in a context of disillusions ? By reconsidering the manner how knowledge relates to Truth, to Good and to the conviction that exists a natural order one could unveil. By banking on the requisits of the scientific activity itself. By considering the conditions which allow to live at best with what we know (science) and what we can do with what we know(technics).

3 CFR - Improving Energy Security, American Competitiveness and Job Creation, and Environmental...

Code of Federal Regulations, 2011 CFR

2011-01-01

... source of fossil fuel consumption and greenhouse gas pollution. I therefore request that the... annual progress in reducing transportation sector emissions and fossil fuel consumption consistent with... substantial annual progress in reducing transportation sector greenhouse gas emissions and fossil fuel...

24 CFR 1006.430 - Corrective and remedial action.

Code of Federal Regulations, 2011 CFR

2011-04-01

... plan; (3) Made substantial progress in carrying out its program and achieving its quantifiable goals as... to submit progress schedules for completing activities or complying with the requirements of the Act... appropriate technical assistance using existing grant funds or other available resources to overcome the...

Acquisition of Scientific Literature in Developing Countries. 2: Malaysia.

ERIC Educational Resources Information Center

Taib, Rosna

1989-01-01

Describes the acquisition of scientific literature by academic libraries in Malaysia. The discussion covers the impact of government policies, library acquisition policies, the selection process, acquisition of special materials, the role of gifts and exchanges, and problems with customs clearance and censorship. Progress in cooperative…

Between a rock and a hard place: Learning to teach science-for-all in an urban district

NASA Astrophysics Data System (ADS)

Galosy, Jodie A.

2005-07-01

Science-for-all, a contemporary science education reform initiative, envisions science classrooms where all students have opportunities to deepen their understanding of scientific concepts and practices. However, national science achievement tests indicate the reality of science-for-all is still very much a work-in-progress. Science-for-all demands much of teachers, especially those working with student populations typically underserved by science education---students of color, students with limited English proficiency, and those from families with limited economic means. A large proportion of those students attend urban districts where they are likely to encounter novice science teachers. This qualitative study investigated learning to teach science-for-all in an urban school district. Seven early career middle and high school science teachers participated in the study. Data collection took place over a period of fourteen months, through interviews and observations with teacher participants, their schools, and in their professional development activities (including new teacher support induction programs). The study examines how new teachers' use of their personal, social, and conventional resources influenced their beliefs and practices relative to science-for-all. Three reform ideals serve as the study's focal points: content goals that emphasize understanding scientific concepts and practices, hands-on activities that support students' intellectual engagement, and literacy strategies that provide access for all students to scientific content. Few novices developed beliefs and practices that supported science-for-all. Those who did brought several key personal resources to their teaching. While these personal resources were important for teacher development, they were not sufficient; novices needed additional resources. Some teachers had access to reform-based conventional resources others did not have. However, personal and social resources shaped how novices used those resources and, in turn, their beliefs about students and teaching practices. Context-specific assistance was a particularly important social resource that was in short supply for most novices. The study provides evidence that progress towards science-for-all will require substantial attention to, and investment in, teacher learning across all dimensions of the professional continuum---pre-service, induction, and in-service. The study also provides insights in two critical areas: strengthening the resources available to early career urban science teachers and shaping resource use towards the goals envisioned in science-for all.

Status Report on the Development of Research Campaigns

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baer, Donald R.; Baker, Scott E.; Washton, Nancy M.

2013-06-30

Research campaigns were conceived as a means to focus EMSL research on specific scientific questions. Campaign will help fulfill the Environmental Molecular Sciences Laboratory (EMSL) strategic vision to develop and integrate, for use by the scientific community, world leading capabilities that transform understanding in the environmental molecular sciences and accelerate discoveries relevant to the Department of Energy’s (DOE’s) missions. Campaigns are multi-institutional multi-disciplinary projects with scope beyond those of normal EMSL user projects. The goal of research campaigns is to have EMSL scientists and users team on the projects in the effort to accelerate progress and increase impact in specificmore » scientific areas by focusing user research, EMSL resources, and expertise in those areas. This report will give a history and update on the progress of those campaigns.« less

Protection of genetic heritage in the era of cloning

PubMed Central

de Oliveira Júnior, Eudes Quintino; de Oliveira, Pedro Bellentani Quintino

2012-01-01

Research on human beings has expanded greatly due to progress and the evolution of society as well as customs. Not only the unceasing development of research on human beings, but also interference in the beginning and end of life with homologous and heterogonous human reproduction, surrogate motherhood, cloning, gene therapies, eugenics, euthanasia, dysthanasia, orthothanasia, assisted suicide, genetic engineering, reassignment surgery in cases of transsexuality, the use of recombinant DNA technology and embryonic stem cells, transplantation of human organs and tissues, biotechnology and many other scientific advances. Scientific progress goes faster than the real needs of human beings, who are the final recipient of the entire evolutionary progress. Hence, there is the need to scrutinize whether new technologies are necessary, suitable and timely so that humanity can achieve its postulate of bene vivere. Human cloning, as an abrupt scientific fact, has presented itself to the world community as a procedure that can be performed with relative success and with little difficulty, since it achieved its objectives with the cloning of Dolly the sheep. This issue became the topic of discussion not only in the scientific community but in the lay population, and it received from both, global disapproval. The conclusion is that the human being is unique, with a life cycle defined by the rules of nature. Reversal will cause a violation of the genetic heritage and, above all, will confront the constitutional principle of human dignity. PMID:23323071

Protection of genetic heritage in the era of cloning.

PubMed

de Oliveira Júnior, Eudes Quintino; de Oliveira, Pedro Bellentani Quintino

2012-01-01

Research on human beings has expanded greatly due to progress and the evolution of society as well as customs. Not only the unceasing development of research on human beings, but also interference in the beginning and end of life with homologous and heterogonous human reproduction, surrogate motherhood, cloning, gene therapies, eugenics, euthanasia, dysthanasia, orthothanasia, assisted suicide, genetic engineering, reassignment surgery in cases of transsexuality, the use of recombinant DNA technology and embryonic stem cells, transplantation of human organs and tissues, biotechnology and many other scientific advances. Scientific progress goes faster than the real needs of human beings, who are the final recipient of the entire evolutionary progress. Hence, there is the need to scrutinize whether new technologies are necessary, suitable and timely so that humanity can achieve its postulate of bene vivere. Human cloning, as an abrupt scientific fact, has presented itself to the world community as a procedure that can be performed with relative success and with little difficulty, since it achieved its objectives with the cloning of Dolly the sheep.This issue became the topic of discussion not only in the scientific community but in the lay population, and it received from both, global disapproval. The conclusion is that the human being is unique, with a life cycle defined by the rules of nature. Reversal will cause a violation of the genetic heritage and, above all, will confront the constitutional principle of human dignity.

Genetic testing for hearing impairment.

PubMed

Topsakal, V; Van Camp, G; Van de Heyning, P

2005-01-01

For some patients, genetic testing can reveal the etiology of their hearing impairment, and can provide evidence for a medical diagnosis. However, a gap between fundamental genetic research on hereditary deafness and clinical otology emerges because of the steadily increasing number of discovered genes for hereditary hearing impairment (HHI) and the comparably low clinical differentiation of the HHIs. In an attempt to keep up with the scientific progress, this article enumerates the indications of genetic testing for HHI from a clinical point of view and describes the most frequently encountered HHIs in Belgium. Domains of recent scientific interest, molecular biological aspects, and some pitfalls with HHIs are highlighted. The overview comprises bilateral congenital hearing loss, late-onset progressive high frequency hearing loss, progressive bilateral cochleo-vestibular deficit, and progressive low frequency hearing loss. Also, several syndromal forms of HHI are summarized, and the availability of genetic tests mentioned. Finally, the requirements for successful linkage analysis, an important genetic research tool for localizing the potential genes of a trait on a chromosome, are briefly described.

Prions: Introducing a Complex Scientific Controversy to a Biology Classroom

ERIC Educational Resources Information Center

Zaitsev, Igor V.

2009-01-01

Thomas Kuhn, in "The Structure of Scientific Revolutions," posited that science does not progress by the steady accumulation of knowledge, but rather by a system of competition among paradigms. They vie for supremacy through greater parsimony, explanatory power, and popularity among the community of scientists (Kuhn, 1962). The current…

[Upon scientific accuracy scheme at clinical specialties].

PubMed

Ortega Calvo, M

2006-11-01

Will be medical specialties like sciences in the future? Yes, progressively they will. Accuracy in clinical specialties will be dissimilar in the future because formal-logic mathematics, quantum physics advances and relativity theory utilities. Evidence based medicine is now helping to clinical specialties on scientific accuracy by the way of decision theory.

The New Morbidity and the Prevention of Mental Retardation.

ERIC Educational Resources Information Center

Baumeister, Alfred A.

1988-01-01

Efforts to prevent mental retardation have been encumbered by lack of scientific and technical knowledge, vague understanding of incidence and prevalence, and scarcity of resources to implement effective public policies. Scientific and social progress toward prevention has pursued a wavelike, erratic course, driven primarily by prevailing social,…

The Institutional Challenges of Cyberinfrastructure and E-Research

ERIC Educational Resources Information Center

Lynch, Clifford

2008-01-01

In thinking about how best to support the changes in scholarly and scientific work and also to accelerate these changes as a way of advancing scientific progress, science funding agencies began speaking about the need to systematically invest in what they called "cyberinfrastructure." This included not just information technologies but…

The Role of the Universities in the Current Scientific and Technological Revolution in the USSR

ERIC Educational Resources Information Center

Nuzhin, M. T.

1975-01-01

The scientific and technological revolution is making progressive changes in the material conditions of economic production in Russia and is actively influencing the development and improvement of education. The influence of university education on the socioeconomic process is discussed. (Author/RM)

Is the cosmopolitanization of science emerging in China?

PubMed

Zhang, Joy Yueyue

2010-12-01

China is one among many other countries that have recognised the necessity in aligning national scientific progress with that of global development. As China is striding along the path of scientific development with determination and initial success, a key concern confronted by international scientific community is how China, a rising scientific power, will transform existing global scientific atlas. Based on a project carried out in six Chinese cities between 2006 to 2009, this paper mainly employs Ulrich Beck's cosmopolitan theory in examining China's life sciences' development in the last decade to investigate how Chinese stakeholders have developed a (cosmopolitan) sensibility to rival ways of scientific reasoning, and in what way, Chinese stakeholders have contributed to the cosmopolitanization of science.

Scientific Autonomy and Public Oversight

PubMed Central

Resnik, David B.

2009-01-01

When scientific research collides with social values, science’s right to self-governance becomes an issue of paramount concern. In this article, I develop an account of scientific autonomy within a framework of public oversight. I argue that scientific autonomy is justified because it promotes the progress of science, which benefits society, but that restrictions on autonomy can also be justified to prevent harm to people, society, or the environment, and to encourage beneficial research. I also distinguish between different ways of limiting scientific autonomy, and I argue that government involvement in scientific decision-making should usually occur through policies that control the process of science, rather than policies that control the content of science. PMID:19777124

Substantial Equivalence Standards in Tobacco Governance: Statutory Clarity and Regulatory Precedent for the FSPTCA.

PubMed

Carpenter, Daniel; Connolly, Gregory N; Lempert, Lauren Kass

2017-08-01

The Family Smoking Prevention and Tobacco Control Act (FSPTCA) of 2009 creates the first national system of premarket regulation of tobacco products in American history. The FDA must now review and give marketing authorization to all new tobacco products, based on a public health standard, before they can be legally marketed. Yet the law also contains an alternative pathway for market entry-the substantial equivalence (SE) clause-by which novel and altered tobacco products can be marketed by demonstrating their substantial equivalence to existing products. Over 99 percent of tobacco product applications sent to the FDA under the new law have used this mechanism, and loose application of the SE mechanism carries the risk of undoing the FDA's gatekeeping power under the law. We review the statutory and regulatory precedent for SE, examining the FSPTCA itself as well as regulatory precedent from drug and device regulation (from which the term substantial equivalence and much of the associated statutory language was derived). Our review of standards and scientific precedent demonstrates that exacting scrutiny under the public health standard should govern all SE reviews and that clinical data incorporating social scientific evidence should be routinely required for SE claims by tobacco product sponsors. Copyright © 2017 by Duke University Press.

WCRP Task Team for the Intercomparison of Reanalyses (TIRA): Motivation and Progress

NASA Technical Reports Server (NTRS)

Bosilovich, Michael

2017-01-01

Reanalyses have proven to be an important resource for weather and climate related research, as well as societal applications at large. Several centers have emerged to produce new atmospheric reanalyses in various forms every few years. In addition, land and ocean communities are producing disciplinary uncoupled reanalyses. Current research and development in reanalysis is directed at (1) extending the length of reanalyzed period and (2) use of coupled Earth system models for climate reanalysis. While WCRPs involvement in the reanalyses communities through its Data Advisory Council (WDAC) has been substantial, for example in organizing international conferences on reanalyses, a central team of reanalyses expertise is not in place in the WCRP structure. The differences among reanalyses and their inherent uncertainties are some of the most important questions for both users and developers of reanalyses. Therefore, a collaborative effort to systematically assess and intercompare reanalyses would be a logical progression that fills the needs of the community and contributes to the WCRP mission. The primary charge to the TIRA is to develop a reanalysis intercomparison project plan that will attain the following objectives.1)To foster understanding and estimation of uncertainties in reanalysis data by intercomparison and other means 2)To communicate new developments and best practices among the reanalyses producing centers 3)To enhance the understanding of data and assimilation issues and their impact on uncertainties, leading to improved reanalyses for climate assessment 4)To communicate the strengths and weaknesses of reanalyses, their fitness for purpose, and best practices in the use of reanalysis datasets by the scientific community. This presentation outlines the need for a task team on reanalyses, their intercomparison, the objectives of the team and progress thus far.

Integrated risk and recovery monitoring of ecosystem restorations on contaminated sites

USGS Publications Warehouse

Hooper, Michael J.; Glomb, Stephen J.; Harper, David; Hoelzle, Timothy B.; McIntosh, Lisa M.; Mulligan, David R.

2016-01-01

Ecological restorations of contaminated sites balance the human and ecological risks of residual contamination with the benefits of ecological recovery and the return of lost ecological function and ecosystem services. Risk and recovery are interrelated dynamic conditions, changing as remediation and restoration activities progress through implementation into long-term management and ecosystem maturation. Monitoring restoration progress provides data critical to minimizing residual contaminant risk and uncertainty, while measuring ecological advancement toward recovery goals. Effective monitoring plans are designed concurrently with restoration plan development and implementation and are focused on assessing the effectiveness of activities performed in support of restoration goals for the site. Physical, chemical, and biotic measures characterize progress toward desired structural and functional ecosystem components of the goals. Structural metrics, linked to ecosystem functions and services, inform restoration practitioners of work plan modifications or more substantial adaptive management actions necessary to maintain desired recovery. Monitoring frequency, duration, and scale depend on specific attributes and goals of the restoration project. Often tied to restoration milestones, critical assessment of monitoring metrics ensures attainment of risk minimization and ecosystem recovery. Finally, interpretation and communication of monitoring findings inform and engage regulators, other stakeholders, the scientific community, and the public. Because restoration activities will likely cease before full ecosystem recovery, monitoring endpoints should demonstrate risk reduction and a successional trajectory toward the condition established in the restoration goals. A detailed assessment of the completed project's achievements, as well as unrealized objectives, attained through project monitoring, will determine if contaminant risk has been minimized, if injured resources have recovered, and if ecosystem services have been returned. Such retrospective analysis will allow better planning for future restoration goals and strengthen the evidence base for quantifying injuries and damages at other sites in the future.

High-End Climate Science: Development of Modeling and Related Computing Capabilities

DTIC Science & Technology

2000-12-01

toward strengthening research on key scientific issues. The Program has supported research that has led to substantial increases in knowledge , improved...provides overall direction and executive oversight of the USGCRP. Within this framework, agencies manage and coordinate Federally supported scientific...critical for the U.S. Global Change Research Program. Such models can be used to look backward to test the consistency of our knowledge of Earth system

Diversity and inclusiveness in large scientific collaborations

NASA Astrophysics Data System (ADS)

Lucatello, Sara; Diamond-Stanic, Aleksandar

2017-06-01

Considerable progress has been made in the past decade to increase diversity in astronomy, and in particular to reach a 'critical mass' of women. It is however important to realize that this progress has mainly been the result of the selective inclusion of women from more privileged backgrounds.

Developing Learning Progression-Based Teacher Knowledge Measures

ERIC Educational Resources Information Center

Jin, Hui; Shin, HyoJeong; Johnson, Michele E.; Kim, JinHo; Anderson, Charles W.

2015-01-01

This study developed learning progression-based measures of science teachers' content knowledge (CK) and pedagogical content knowledge (PCK). The measures focus on an important topic in secondary science curriculum using scientific reasoning (i.e., tracing matter, tracing energy, and connecting scales) to explain plants gaining weight and…

Priorities for research in soil ecology

PubMed Central

Eisenhauer, Nico; Antunes, Pedro M.; Bennett, Alison E.; Birkhofer, Klaus; Bissett, Andrew; Bowker, Matthew A.; Caruso, Tancredi; Chen, Baodong; Coleman, David C.; de Boer, Wietse; de Ruiter, Peter; DeLuca, Thomas H.; Frati, Francesco; Griffiths, Bryan S.; Hart, Miranda M.; Hättenschwiler, Stephan; Haimi, Jari; Heethoff, Michael; Kaneko, Nobuhiro; Kelly, Laura C.; Leinaas, Hans Petter; Lindo, Zoë; Macdonald, Catriona; Rillig, Matthias C.; Ruess, Liliane; Scheu, Stefan; Schmidt, Olaf; Seastedt, Timothy R.; van Straalen, Nico M.; Tiunov, Alexei V.; Zimmer, Martin; Powell, Jeff R.

2017-01-01

The ecological interactions that occur in and with soil are of consequence in many ecosystems on the planet. These interactions provide numerous essential ecosystem services, and the sustainable management of soils has attracted increasing scientific and public attention. Although soil ecology emerged as an independent field of research many decades ago, and we have gained important insights into the functioning of soils, there still are fundamental aspects that need to be better understood to ensure that the ecosystem services that soils provide are not lost and that soils can be used in a sustainable way. In this perspectives paper, we highlight some of the major knowledge gaps that should be prioritized in soil ecological research. These research priorities were compiled based on an online survey of 32 editors of Pedobiologia – Journal of Soil Ecology. These editors work at universities and research centers in Europe, North America, Asia, and Australia.The questions were categorized into four themes: (1) soil biodiversity and biogeography, (2) interactions and the functioning of ecosystems, (3) global change and soil management, and (4) new directions. The respondents identified priorities that may be achievable in the near future, as well as several that are currently achievable but remain open. While some of the identified barriers to progress were technological in nature, many respondents cited a need for substantial leadership and goodwill among members of the soil ecology research community, including the need for multi-institutional partnerships, and had substantial concerns regarding the loss of taxonomic expertise. PMID:29129942

Acute and non-acute effects of cannabis on brain functioning and neuropsychological performance.

PubMed

Gonzalez, Raul

2007-09-01

Cannabis has an ancient history of human use and is currently one of the most commonly used drugs worldwide. Understanding its impact on neurobehavioral functioning is of significant public health concern. In recent decades, substantial progress has been made in understanding the impact of cannabis use on neurobehavioral functioning. This has been fueled, in part, by characterization of an endocannabinoid signaling system in the brain through which cannabis exerts its psychoactive effects. Acute intoxication with cannabis causes marked changes in subjective mental status, brain functioning, and neuropsychological performance. Some of these changes are consistently detected and well characterized, yet others are not. Changes in brain functioning and neuropsychological performance are also reported after abstinence, but appear to be mild, circumscribed, and transient. On the other hand, functional neuroimaging often reveals subtle differences in the brain functioning of abstinent cannabis users compared with controls. The persistence and clinical significance of these differences, however, remains to be determined. Neuropsychological deficits and differences in brain functioning are most consistently observed only among frequent, heavy users, who are those most likely addicted to cannabis. The dire impact of drug addiction on a person's life and everyday functioning suggests that the large number of individuals addicted to cannabis experience substantial negative effects from its use. This manuscript reviews the scientific literature on the aforementioned topics in detail, providing evidence for converging findings, and highlighting areas in need of further investigation.

Priorities for research in soil ecology.

PubMed

Eisenhauer, Nico; Antunes, Pedro M; Bennett, Alison E; Birkhofer, Klaus; Bissett, Andrew; Bowker, Matthew A; Caruso, Tancredi; Chen, Baodong; Coleman, David C; de Boer, Wietse; de Ruiter, Peter; DeLuca, Thomas H; Frati, Francesco; Griffiths, Bryan S; Hart, Miranda M; Hättenschwiler, Stephan; Haimi, Jari; Heethoff, Michael; Kaneko, Nobuhiro; Kelly, Laura C; Leinaas, Hans Petter; Lindo, Zoë; Macdonald, Catriona; Rillig, Matthias C; Ruess, Liliane; Scheu, Stefan; Schmidt, Olaf; Seastedt, Timothy R; van Straalen, Nico M; Tiunov, Alexei V; Zimmer, Martin; Powell, Jeff R

2017-07-01

The ecological interactions that occur in and with soil are of consequence in many ecosystems on the planet. These interactions provide numerous essential ecosystem services, and the sustainable management of soils has attracted increasing scientific and public attention. Although soil ecology emerged as an independent field of research many decades ago, and we have gained important insights into the functioning of soils, there still are fundamental aspects that need to be better understood to ensure that the ecosystem services that soils provide are not lost and that soils can be used in a sustainable way. In this perspectives paper, we highlight some of the major knowledge gaps that should be prioritized in soil ecological research. These research priorities were compiled based on an online survey of 32 editors of Pedobiologia - Journal of Soil Ecology. These editors work at universities and research centers in Europe, North America, Asia, and Australia.The questions were categorized into four themes: (1) soil biodiversity and biogeography, (2) interactions and the functioning of ecosystems, (3) global change and soil management, and (4) new directions. The respondents identified priorities that may be achievable in the near future, as well as several that are currently achievable but remain open. While some of the identified barriers to progress were technological in nature, many respondents cited a need for substantial leadership and goodwill among members of the soil ecology research community, including the need for multi-institutional partnerships, and had substantial concerns regarding the loss of taxonomic expertise.

The Mixed Economic Progress of Immigrants.

ERIC Educational Resources Information Center

Schoeni, Robert F.; And Others

This report examines whether the economic well-being of male immigrants to the United States improves substantially over time, details differences in economic progress of immigrants from different countries of origin, and assesses the impact of educational attainment on immigrants' earnings. Analyses are based on Public Use Micro Samples of the…

Transforming Performance Measurement for the 21st Century

ERIC Educational Resources Information Center

Hatry, Harry P.

2014-01-01

While substantial progress has been made in spreading performance measurement across the country and world, much of the information from performance measurement systems has been shallow. Modern technology and the considerable demand for information on progress in achieving the outcomes of public programs and policies are creating major…

THE DISADVANTAGED CHILDREN AND YOUTH OF AMERICA.

ERIC Educational Resources Information Center

OETTINGER, KATHERINE B.

PROGRESS IS BEING MADE TOWARD ERASING THE DISADVANTAGES OF THE MENTALLY RETARDED. MUCH PROGRESS HAS BEEN MADE IN RECOGNIZING THE HEALTH NEEDS OF THE RETARDED CHILD THROUGH SUBSTANTIAL LEGISLATION SPONSORED BY MANY BRANCHES OF GOVERNMENT, ACTION PROGRAMS STEMMING FROM BOTH PUBLIC AND VOLUNTARY SOURCES, AND A MOUNTING RESEARCH EFFORT. IN AN EFFORT…

Evaluating Test Validity: Reprise and Progress

ERIC Educational Resources Information Center

Shepard, Lorrie A.

2016-01-01

The AERA, APA, NCME Standards define validity as "the degree to which evidence and theory support the interpretations of test scores for proposed uses of tests". A century of disagreement about validity does not mean that there has not been substantial progress. This consensus definition brings together interpretations and use so that it…

Personality psychology: lexical approaches, assessment methods, and trait concepts reveal only half of the story--why it is time for a paradigm shift.

PubMed

Uher, Jana

2013-03-01

This article develops a comprehensive philosophy-of-science for personality psychology that goes far beyond the scope of the lexical approaches, assessment methods, and trait concepts that currently prevail. One of the field's most important guiding scientific assumptions, the lexical hypothesis, is analysed from meta-theoretical viewpoints to reveal that it explicitly describes two sets of phenomena that must be clearly differentiated: 1) lexical repertoires and the representations that they encode and 2) the kinds of phenomena that are represented. Thus far, personality psychologists largely explored only the former, but have seriously neglected studying the latter. Meta-theoretical analyses of these different kinds of phenomena and their distinct natures, commonalities, differences, and interrelations reveal that personality psychology's focus on lexical approaches, assessment methods, and trait concepts entails a) erroneous meta-theoretical assumptions about what the phenomena being studied actually are, and thus how they can be analysed and interpreted, b) that contemporary personality psychology is largely based on everyday psychological knowledge, and c) a fundamental circularity in the scientific explanations used in trait psychology. These findings seriously challenge the widespread assumptions about the causal and universal status of the phenomena described by prominent personality models. The current state of knowledge about the lexical hypothesis is reviewed, and implications for personality psychology are discussed. Ten desiderata for future research are outlined to overcome the current paradigmatic fixations that are substantially hampering intellectual innovation and progress in the field.

Geomorphology and American dams: The scientific, social, and economic context

NASA Astrophysics Data System (ADS)

Graf, William L.

2005-10-01

American geomorphologic research related to dams is embedded in a complicated context of science, policy, economics, and culture. Research into the downstream effects of large dams has progressed to the point of theory-building, but generalization and theory-building are from this research because (1) it is highly focused on a few locations, (2) it concerns mostly very large dams rather than a representative sample of sizes, (3) the available record of effects is too short to inform us on long-term changes, (4) the reversibility of changes imposed by dam installation and operation is unknown, and (5) coordinated funding for the needed research is scarce. In the scientific context, present research is embedded in a history of geomorphology in government service, with indistinct boundaries between "basic and applied" research. The federal policy that most strongly influences present geomorphological investigations connected with dams is related to habitat for endangered species, because the biological aspects of ecosystems are directly dependent on the substrate formed by the sediments and landforms that are influenced by dams. The economic context for research includes large amounts of public funds for river restoration, along with substantial private investments in dams; and geomorphology is central to these expensive issues. The cultural context for research is highly contentious and dominated by advocacy procedures that include intense scrutiny of any geomorphologic research related to dams. Advocates are likely to use the products of geomorphological research to make cases for their own positions.

Development of hybrid 3-D hydrological modeling for the NCAR Community Earth System Model (CESM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeng, Xubin; Troch, Peter; Pelletier, Jon

2015-11-15

This is the Final Report of our four-year (3-year plus one-year no cost extension) collaborative project between the University of Arizona (UA) and the National Center for Atmospheric Research (NCAR). The overall objective of our project is to develop and evaluate the first hybrid 3-D hydrological model with a horizontal grid spacing of 1 km for the NCAR Community Earth System Model (CESM). We have made substantial progress in model development and evaluation, computational efficiencies and software engineering, and data development and evaluation, as discussed in Sections 2-4. Section 5 presents our success in data dissemination, while Section 6 discussesmore » the scientific impacts of our work. Section 7 discusses education and mentoring success of our project, while Section 8 lists our relevant DOE services. All peer-reviewed papers that acknowledged this project are listed in Section 9. Highlights of our achievements include: • We have finished 20 papers (most published already) on model development and evaluation, computational efficiencies and software engineering, and data development and evaluation • The global datasets developed under this project have been permanently archived and publicly available • Some of our research results have already been implemented in WRF and CLM • Patrick Broxton and Michael Brunke have received their Ph.D. • PI Zeng has served on DOE proposal review panels and DOE lab scientific focus area (SFA) review panels« less

When data sharing gets close to 100%: what human paleogenetics can teach the open science movement.

PubMed

Anagnostou, Paolo; Capocasa, Marco; Milia, Nicola; Sanna, Emanuele; Battaggia, Cinzia; Luzi, Daniela; Destro Bisol, Giovanni

2015-01-01

This study analyzes data sharing regarding mitochondrial, Y chromosomal and autosomal polymorphisms in a total of 162 papers on ancient human DNA published between 1988 and 2013. The estimated sharing rate was not far from totality (97.6% ± 2.1%) and substantially higher than observed in other fields of genetic research (evolutionary, medical and forensic genetics). Both a questionnaire-based survey and the examination of Journals' editorial policies suggest that this high sharing rate cannot be simply explained by the need to comply with stakeholders requests. Most data were made available through body text, but the use of primary databases increased in coincidence with the introduction of complete mitochondrial and next-generation sequencing methods. Our study highlights three important aspects. First, our results imply that researchers' awareness of the importance of openness and transparency for scientific progress may complement stakeholders' policies in achieving very high sharing rates. Second, widespread data sharing does not necessarily coincide with a prevalent use of practices which maximize data findability, accessibility, useability and preservation. A detailed look at the different ways in which data are released can be very useful to detect failures to adopt the best sharing modalities and understand how to correct them. Third and finally, the case of human paleogenetics tells us that a widespread awareness of the importance of Open Science may be important to build reliable scientific practices even in the presence of complex experimental challenges.

Scientific Knowledge Discovery in Complex Semantic Networks of Geophysical Systems

NASA Astrophysics Data System (ADS)

Fox, P.

2012-04-01

The vast majority of explorations of the Earth's systems are limited in their ability to effectively explore the most important (often most difficult) problems because they are forced to interconnect at the data-element, or syntactic, level rather than at a higher scientific, or semantic, level. Recent successes in the application of complex network theory and algorithms to climate data, raise expectations that more general graph-based approaches offer the opportunity for new discoveries. In the past ~ 5 years in the natural sciences there has substantial progress in providing both specialists and non-specialists the ability to describe in machine readable form, geophysical quantities and relations among them in meaningful and natural ways, effectively breaking the prior syntax barrier. The corresponding open-world semantics and reasoning provide higher-level interconnections. That is, semantics provided around the data structures, using semantically-equipped tools, and semantically aware interfaces between science application components allowing for discovery at the knowledge level. More recently, formal semantic approaches to continuous and aggregate physical processes are beginning to show promise and are soon likely to be ready to apply to geoscientific systems. To illustrate these opportunities, this presentation presents two application examples featuring domain vocabulary (ontology) and property relations (named and typed edges in the graphs). First, a climate knowledge discovery pilot encoding and exploration of CMIP5 catalog information with the eventual goal to encode and explore CMIP5 data. Second, a multi-stakeholder knowledge network for integrated assessments in marine ecosystems, where the data is highly inter-disciplinary.

Drinking policies and exercise-associated hyponatraemia: is anyone still promoting overdrinking?

PubMed

Beltrami, F G; Hew-Butler, T; Noakes, T D

2008-10-01

The purpose of this review is to describe the evolution of hydration research and advice on drinking during exercise from published scientific papers, books and non-scientific material (advertisements and magazine contents) and detail how erroneous advice is likely propagated throughout the global sports medicine community. Hydration advice from sports-linked entities, the scientific community, exercise physiology textbooks and non-scientific sources was analysed historically and compared with the most recent scientific evidence. Drinking policies during exercise have changed substantially throughout history. Since the mid-1990s, however, there has been an increase in the promotion of overdrinking by athletes. While the scientific community is slowly moving away from "blanket" hydration advice in which one form of advice fits all and towards more modest, individualised, hydration guidelines in which thirst is recognised as the best physiological indicator of each subject's fluid needs during exercise, marketing departments of the global sports drink industry continue to promote overdrinking.

Communicating Science Broadly: An NSF Point of View

NASA Astrophysics Data System (ADS)

Leinen, M. S.

2006-12-01

In the view of NSF, communicating about both the process of doing science and about scientific results are of paramount importance. But those of us in the agency are not the ones who do the science or generate the results. Thus, our policy is to encourage the community we fund to communicate their results as broadly as possible. Why does NSF feel so strongly about communicating scientific results? First, science only moves forward when there is free and open debate about scientific results through public mechanisms in which there is an opportunity for thorough analysis (e.g. scientific literature, professional meetings and workshops). Second, the research we support is done for the good of the public and should be communicated to the public. Third, scientific results are critical to many important decision-making processes and policy-making processes. Democracies thrive when an informed public is engaged, so communicating science broadly to the lay public is important. Why does NSF feel so strongly about communicating about the process of science? Science is a habit of mind; an orderly process for testing ideas. But many do not understand how science is done, the difference between fact and conjecture, why speculation, hypotheses and theory are critical to progress, or why the culture of constructive criticism is essential to progress. Without this context, science can be misunderstood as magic, opinion, or argument. Thus the efforts that we fund to enhance scientific education and outreach are critical to having discourse about scientific results.

Particle acceleration, transport and turbulence in cosmic and heliospheric physics

NASA Technical Reports Server (NTRS)

Matthaeus, W.

1992-01-01

In this progress report, the long term goals, recent scientific progress, and organizational activities are described. The scientific focus of this annual report is in three areas: first, the physics of particle acceleration and transport, including heliospheric modulation and transport, shock acceleration and galactic propagation and reacceleration of cosmic rays; second, the development of theories of the interaction of turbulence and large scale plasma and magnetic field structures, as in winds and shocks; third, the elucidation of the nature of magnetohydrodynamic turbulence processes and the role such turbulence processes might play in heliospheric, galactic, cosmic ray physics, and other space physics applications.

The Impact of Research on the Future of Dental Education: How Research and Innovation Shape Dental Education and the Dental Profession.

PubMed

Slavkin, Harold C

2017-09-01

Scientific inquiry and discovery are the fuel for education, research, technology, and health care in all the health professions: dentistry, medicine, nursing, pharmacy, and allied health sciences. The progression of discoveries from basic or fundamental to clinical research is followed by the progression from clinical to implementation and improved health outcomes and processes. Generally, implementation science is the scientific study of methods to promote the systematic uptake of research findings (e.g., basic, translational, behavioral, socioeconomic, and clinical) as well as other related evidence-based practices into standards of care, thereby improving the quality, effectiveness, and cost benefits of health care services. There is little doubt that science has and will continue to provide the essential fuel for innovations that lead to new and improved technologies for risk assessment, prevention, diagnosis, treatments and therapeutics, and implementation for addressing oral and craniofacial diseases and disorders. The history of the U.S. dental profession reviewed in this article gives testimony to the continued need for investments in scientific inquiry that accelerate progress in comprehensive health care for all people. This article was written as part of the project "Advancing Dental Education in the 21 st Century."

Exploring hypothetical learning progressions for the chemistry of nitrogen and nuclear processes

NASA Astrophysics Data System (ADS)

Henry, Deborah McKern

Chemistry is a bridge that connects a number of scientific disciplines. High school students should be able to determine whether scientific information is accurate, how chemistry applies to daily life, and the mechanism by which systems operate (NRC, 2012). This research focuses on describing hypothetical learning progressions for student understanding of the chemical reactions of nitrogen and nuclear processes and examines whether there is consistency in scientific reasoning between these two distinct conceptual areas. The constant comparative method was used to analyze the written products of students including homework, formative and summative tests, laboratory notebooks, reflective journals, written presentations, and discussion board contributions via Edmodo (an online program). The ten participants were 15 and 16 year old students enrolled in a general high school chemistry course. Instruction took place over a ten week period. The learning progression levels ranged from 0 to 4 and were described as missing, novice, intermediate, proficient, and expert. The results were compared to the standards set by the NRC with a lower anchor (expectations for grade 8) and upper anchor (expectations for grade 12). The results indicate that, on average, students were able to reach an intermediate level of understanding for these concepts.

Laser Ranging to the Moon: How Evolving Technology Enables New Science

NASA Astrophysics Data System (ADS)

Faller, James

2010-03-01

Technological advances have long been the enabler of scientific progress. The invention of the laser is a prime example of this symbiotic relationship between technical progress and scientific advances. The laser, which today is omnipresent in each of our lives, made its first appearance during the time that I was a graduate student in Professor Dicke's group at Princeton. A major change occurring during that time period was that technology was transforming the study of gravitational physics from just a theoretical subject into also an experimental subject where one could hope to measure things using by-then-available laboratory technologies and techniques. During this same time, the idea for the lunar laser ranging experiment was born. The history and accomplishments of this experiment--a still ongoing experiment which is one of the real scientific triumphs of NASA's Apollo program--will be given.

'I have faith in science and in God': Common sense, cognitive polyphasia and attitudes to science in Nigeria.

PubMed

Falade, Bankole A; Bauer, Martin W

2018-01-01

This study, of modern common sense in Nigeria, combines questionnaires and interviews to examine the compatibility and incompatibility of religion and science. Nigeria is a large country with a complex diversity of religious, ethnic and cultural practices that condition the reception and elaboration of science in everyday life. We find evaluative attitudes to science structured as 'progress', 'fear' and 'mythical image'. Scientific knowledge and religiosity have a direct bearing on expectations of progress and feeling of fear and worry about science; mythical image is independent of this. Nigerians trust both scientific and religious authorities in contrast to other social actors. Many of the results are consistent with the hypothesis of cognitive polyphasia of scientific and religious knowing manifesting as a 'hierarchy', when one form is elevated over the other; 'parallelity', when both serve separate functions; and 'empowerment', where one enhances the other.

Article-level assessment of influence and translation in biomedical research

PubMed Central

Santangelo, George M.

2017-01-01

Given the vast scale of the modern scientific enterprise, it can be difficult for scientists to make judgments about the work of others through careful analysis of the entirety of the relevant literature. This has led to a reliance on metrics that are mathematically flawed and insufficiently diverse to account for the variety of ways in which investigators contribute to scientific progress. An urgent, critical first step in solving this problem is replacing the Journal Impact Factor with an article-level alternative. The Relative Citation Ratio (RCR), a metric that was designed to serve in that capacity, measures the influence of each publication on its respective area of research. RCR can serve as one component of a multifaceted metric that provides an effective data-driven supplement to expert opinion. Developing validated methods that quantify scientific progress can help to optimize the management of research investments and accelerate the acquisition of knowledge that improves human health. PMID:28559438

Long-Range Trends in the Development of Higher Education in Mining

ERIC Educational Resources Information Center

Pzhevskii, V. V.

1978-01-01

Reviews the relationship between scientific and technological progress, needs of the Soviet economy, and capacities of higher education institutions in terms of the future of the mining industry. Mining specialists will have to prepare for technical progress in the extracting industries, growth in production, complex mechanization, and automation…

The Infusion of Corporate Values into Progressive Education: Professional Vulnerability or Complicity?

ERIC Educational Resources Information Center

Gamson, David A.

2004-01-01

Examines the history of educational administration in the USA during the Progressive era (1890-1940). Using Callahan's Education and the Cult of Efficiency as a starting point, examines school district-based administrative practices that offered viable alternatives to the business-oriented, "scientific management" reforms that tended to…

The Relationship between Statistical Analysis Abilities and the Production of Research among Saudi Faculty Members

ERIC Educational Resources Information Center

Al-Hattami, Abdulghani Ali Dawod; Al-Ahdal, Arif Ahmed Mohammed Hassa

2015-01-01

Scientific research plays an important role in creating growth and progress in developing countries (Greenstone, 2010). Developed countries have realized that importance and focused on conducting scientific researches to help them make valuable decisions. Many Arab countries, including Saudi Arabia, are trying to encourage faculty members at all…

Measuring Graph Comprehension, Critique, and Construction in Science

ERIC Educational Resources Information Center

Lai, Kevin; Cabrera, Julio; Vitale, Jonathan M.; Madhok, Jacquie; Tinker, Robert; Linn, Marcia C.

2016-01-01

Interpreting and creating graphs plays a critical role in scientific practice. The K-12 Next Generation Science Standards call for students to use graphs for scientific modeling, reasoning, and communication. To measure progress on this dimension, we need valid and reliable measures of graph understanding in science. In this research, we designed…

Scientific and Technical Information Transfer for Education (STITE). Research Report No. 2.

ERIC Educational Resources Information Center

Zunde, Pranas

STITE (Scientific and Technical Information Transfer for Education) is basically a system to interface between science information and the science learner. As such STITE acts as a link between STIC (Science and Technology Infromation Centers) and LIS (Learning Information Systems). In this second progress report the internal knowledge of STITE is…

What's the Harm? Harms in Research with Adults with Intellectual Disability

ERIC Educational Resources Information Center

McDonald, Katherine E.; Conroy, Nicole E.; Olick, Robert S.

2017-01-01

Scientific advances can improve the lives of adults with intellectual disability, yet concerns that research participation may impose harm impede scientific progress. What counts as harmful can be subjective and perceptions of harm may vary among stakeholders. We studied perspectives on the harmfulness of research events among adults with…

Recognizing Mechanistic Reasoning in Student Scientific Inquiry: A Framework for Discourse Analysis Developed from Philosophy of Science

ERIC Educational Resources Information Center

Russ, Rosemary S.; Scherr, Rachel E.; Hammer, David; Mikeska, Jamie

2008-01-01

Science education reform has long focused on assessing student inquiry, and there has been progress in developing tools specifically with respect to experimentation and argumentation. We suggest the need for attention to another aspect of inquiry, namely "mechanistic reasoning." Scientific inquiry focuses largely on understanding causal…

[Historical heritage and medical progress: the destiny of the scientific collections in the 'modern' Hospital of Santa Maria Nuova in Florence].

PubMed

Diana, Esther

2008-01-01

The scientific collections of Florentine Santa Maria Nuova Hospital stimulated new interest in the second half of eigthteenth century. Indeed, the modernization process of the Hospital lead to a steadily increasing alienation of its rich historical heritage, including the scientific collections. Archive documents witness the sale or the museum valorization of a number of collections including mathematical instruments and the anatomical, surgical and wax-obstetrical ones.

A Progressive Reading, Writing, and Artistic Module to Support Scientific Literacy.

PubMed

Stockwell, Stephanie B

2016-03-01

Scientific literacy, marked by the ability and willingness to engage with scientific information, is supported through a new genre of citizen science-course-based research in association with undergraduate laboratories. A three-phased progressive learning module was developed to enhance student engagement in such contexts while supporting three learning outcomes: I) present an argument based on evidence, II) analyze science and scientists within a social context, and III) experience, reflect upon, and communicate the nature of scientific discovery. Phase I entails guided reading and reflection of citizen science-themed texts. In Phase II, students write, peer-review, and edit position and counterpoint papers inspired by the following prompt, "Nonscientists should do scientific research." Phase III involves two creative assignments intended to communicate the true nature of science. Students work collaboratively to develop public service announcement-like poster campaigns to debunk a common misconception about the nature of science or scientists. Individually, they create a work of art to communicate a specific message about the raw experience of performing scientific research. Suggestions for implementation and modifications are provided. Strengths of the module include the development of transferable skills, temporal distribution of grading demands, minimal in-class time needed for implementation, and the inclusion of artistic projects to support affective learning domains. This citizen science-themed learning module is an excellent complement to laboratory coursework, as it serves to surprise, challenge, and inspire students while promoting disciplinary values.

Evolution of a Materials Data Infrastructure

NASA Astrophysics Data System (ADS)

Warren, James A.; Ward, Charles H.

2018-06-01

The field of materials science and engineering is writing a new chapter in its evolution, one of digitally empowered materials discovery, development, and deployment. The 2008 Integrated Computational Materials Engineering (ICME) study report helped usher in this paradigm shift, making a compelling case and strong recommendations for an infrastructure supporting ICME that would enable access to precompetitive materials data for both scientific and engineering applications. With the launch of the Materials Genome Initiative in 2011, which drew substantial inspiration from the ICME study, digital data was highlighted as a core component of a Materials Innovation Infrastructure, along with experimental and computational tools. Over the past 10 years, our understanding of what it takes to provide accessible materials data has matured and rapid progress has been made in establishing a Materials Data Infrastructure (MDI). We are learning that the MDI is essential to eliminating the seams between experiment and computation by providing a means for them to connect effortlessly. Additionally, the MDI is becoming an enabler, allowing materials engineering to tie into a much broader model-based engineering enterprise for product design.

Traumatic brain injury in modern war

NASA Astrophysics Data System (ADS)

Ling, Geoffrey S. F.; Hawley, Jason; Grimes, Jamie; Macedonia, Christian; Hancock, James; Jaffee, Michael; Dombroski, Todd; Ecklund, James M.

2013-05-01

Traumatic brain injury (TBI) is common and especially with military service. In Iraq and Afghanistan, explosive blast related TBI has become prominent and is mainly from improvised explosive devices (IED). Civilian standard of care clinical practice guidelines (CPG) were appropriate has been applied to the combat setting. When such CPGs do not exist or are not applicable, new practice standards for the military are created, as for TBI. Thus, CPGs for prehospital care of combat TBI CPG [1] and mild TBI/concussion [2] were introduced as was a DoD system-wide clinical care program, the first large scale system wide effort to address all severities of TBI in a comprehensive organized way. As TBI remains incompletely understood, substantial research is underway. For the DoD, leading this effort are The Defense and Veterans Brain Injury Center, National Intrepid Center of Excellence and the Defense Centers of Excellence for Psychological Health and Traumatic Brain Injury. This program is a beginning, a work in progress ready to leverage advances made scientifically and always with the intent of providing the best care to its military beneficiaries.

Academic College of Emergency Experts in India's INDO-US Joint Working Group and OPUS12 Foundation Consensus Statement on Creating A Coordinated, Multi-Disciplinary, Patient-Centered, Global Point-of-Care Biomarker Discovery Network.

PubMed

Stawicki, Stanislaw P; Stoltzfus, Jill C; Aggarwal, Praveen; Bhoi, Sanjeev; Bhatt, Shashi; Kalra, O P; Bhalla, Ashish; Hoey, Brian A; Galwankar, Sagar C; Paladino, Lorenzo; Papadimos, Thomas J

2014-07-01

Biomarker science brings great promise to clinical medicine. This is especially true in the era of technology miniaturization, rapid dissemination of knowledge, and point-of-care (POC) implementation of novel diagnostics. Despite this tremendous progress, the journey from a candidate biomarker to a scientifically validated biomarker continues to be an arduous one. In addition to substantial financial resources, biomarker research requires considerable expertise and a multidisciplinary approach. Investigational designs must also be taken into account, with the randomized controlled trial remaining the "gold standard". The authors present a condensed overview of biomarker science and associated investigational methods, followed by specific examples from clinical areas where biomarker development and/or implementation resulted in tangible enhancements in patient care. This manuscript also serves as a call to arms for the establishment of a truly global, well-coordinated infrastructure dedicated to biomarker research and development, with focus on delivery of the latest discoveries directly to the patient via point-of-care technology.

The deep underground science and engineering laboratory at Homestake

NASA Astrophysics Data System (ADS)

Lesko, Kevin T.

2009-06-01

The US National Science Foundation and the US underground science community are well into the campaign to establish a world-class, multi-disciplinary deep underground science and engineering laboratory — DUSEL. The NSF's review committee, following the first two NSF solicitations, selected Homestake as the prime site to be developed into an international, multidisciplinary, world-class research facility. Homestake DUSEL will provide much needed underground research space to help relieve the worldwide shortage, particularly at great depth, and will develop research campuses at different depths to satisfy the research requirements for the coming decades. The State of South Dakota has demonstrated remarkable support for the project and has secured the site with the transfer of the former Homestake Gold Mine and has initiated re-entry and rehabilitation of the facility to host a modest interim science program with state funds and those from a substantial philanthropic donor. I review the scientific case for DUSEL and the progress in developing the preliminary design of DUSEL in Homestake and the initial suite of experiments to be funded along with the facility.

The Deep Underground Science and Engineering Laboratory at Homestake

NASA Astrophysics Data System (ADS)

Lesko, Kevin T.

2009-12-01

The US National Science Foundation and the US underground science community are well into the campaign to establish a world-class, multi-disciplinary deep underground science and engineering laboratory—DUSEL. The NSF's review committee, following the first two NSF solicitations, selected Homestake as the prime site to be developed into an international, multidisciplinary, world-class research facility. Homestake DUSEL will provide much needed underground research space to help relieve the worldwide shortage, particularly at great depth, and will develop research campuses at different depths to satisfy the research requirements for the coming decades. The State of South Dakota demonstrates remarkable support for the project and has secured the site with the transfer of the former Homestake Gold Mine and has initiated re-entry and rehabilitation of the facility to host a modest interim science program with state funds and those from a substantial philanthropic donor. I review the scientific case for DUSEL and the progress in developing the preliminary design of DUSEL in Homestake and the integrated suite of experiments to be funded along with the facility.

Space Weather Needs of an Evolving Customer Base (Invited)

NASA Astrophysics Data System (ADS)

Rutledge, B.; Viereck, R. A.; Onsager, T. G.

2013-12-01

Great progress has been made in raising the global awareness of space weather and the associated impacts on Earth and our technological systems. However, significant gaps still exist in providing comprehensive and easily understood space weather information, products, and services to the diverse and growing customer base. As technologies, such as Global Navigation Satellite Systems (GNSS), have become more ingrained in applications and fields of work that previously did not rely on systems sensitive to space weather, the customer base has grown substantially. Furthermore, the causes and effects of space weather can be difficult to interpret without a detailed understanding of the scientific underpinnings. In response to this change, space weather service providers must address this evolution by both improving services and by representing space weather information and impacts in ways that are meaningful to each facet of this diverse customer base. The NOAA Space Weather Prediction Center (SWPC) must work with users, spanning precision agriculture, emergency management, power grid operators and beyond, to both identify unmet space weather service requirements and to ensure information and decision support services are provided in meaningful and more easily understood forms.

Evidence and resources to implement Pharmacogenetic Knowledge for Precision Medicine

PubMed Central

Caudle, Kelly E.; Gammal, Roseann S.; Whirl-Carrillo, Michelle; Hoffman, James M.; Relling, Mary V.; Klein, Teri E.

2016-01-01

Purpose Implementation of pharmacogenetics into clinical practice has been relatively slow despite substantial scientific progress over the last decade. One barrier that inhibits uptake of pharmacogenetics into routine clinical practice is the lack of knowledge of how to translate a genetic test into a clinical action based on current evidence. The purpose of this paper is to describe the current state of pharmacogenetic evidence and evidence-based resources that facilitate the uptake of pharmacogenetics into clinical practice. Summary Controversy exists over the required evidence threshold needed for routine clinical implementation of pharmacogenetics. Large randomized controlled trials are not clinically feasible or necessary for many pharmacogenetic applications. Online resources exist like the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Pharmacogenomics Knowledgebase (PharmGKB) that provide freely available, evidence-based resources that facilitate the translation of genetic laboratory test results into actionable prescribing recommendations for specific drugs. Conclusion Resources provided by organizations such as CPIC and PharmGKB that use standardized approaches to evaluate the literature and provide clinical guidance are essential for the implementation of pharmacogenetics into routine clinical practice. PMID:27864205

[Good for your health? An analysis of the requirements for scientific substantiation in European health claims regulation].

PubMed

Todt, Oliver; Luján, José Luis

2016-06-01

To identify the various types of evidence, as well as their relative importance in European health claims regulation, in order to analyze the consequences for consumer protection of the requirements for scientific substantiation in this regulation. Qualitative analysis of various documents relevant to the regulatory process, particularly as to the implications of the standards of proof for the functional food market, as well as consumer behavior. European regulation defines a hierarchy of evidence that turns randomized controlled trials into a necessary and sufficient condition for health claim authorizations. Consumer protection can be interpreted in different manners. High standards of proof protect consumers from false information about the health outcomes of functional foods, while lower standards lead to more, albeit less accurate information about such outcomes being available to consumers.

Is the cosmopolitanization of science emerging in China?

PubMed Central

Zhang, Joy Yueyue

2013-01-01

China is one among many other countries that have recognised the necessity in aligning national scientific progress with that of global development. As China is striding along the path of scientific development with determination and initial success, a key concern confronted by international scientific community is how China, a rising scientific power, will transform existing global scientific atlas. Based on a project carried out in six Chinese cities between 2006 to 2009, this paper mainly employs Ulrich Beck’s cosmopolitan theory in examining China’s life sciences’ development in the last decade to investigate how Chinese stakeholders have developed a (cosmopolitan) sensibility to rival ways of scientific reasoning, and in what way, Chinese stakeholders have contributed to the cosmopolitanization of science. PMID:24244045

Exploiting the Use of Social Networking to Facilitate Collaboration in the Scientific Community

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coppock, Edrick G.

The goal of this project was to exploit social networking to facilitate scientific collaboration. The project objective was to research and identify scientific collaboration styles that are best served by social networking applications and to model the most effective social networking applications to substantiate how social networking can support scientific collaboration. To achieve this goal and objective, the project was to develop an understanding of the types of collaborations conducted by scientific researchers, through classification, data analysis and identification of unique collaboration requirements. Another technical objective in support of this goal was to understand the current state of technology inmore » collaboration tools. In order to test hypotheses about which social networking applications effectively support scientific collaboration the project was to create a prototype scientific collaboration system. The ultimate goal for testing the hypotheses and research of the project was to refine the prototype into a functional application that could effectively facilitate and grow collaboration within the U.S. Department of Energy (DOE) research community.« less

49 CFR 213.113 - Defective rails.

Code of Federal Regulations, 2010 CFR

2010-10-01

... smooth, bright, or dark, round or oval surface substantially at a right angle to the length of the rail... in the head of the rail as a smooth, bright, or dark surface progressing until substantially at a... head, and extending into or through it. A crack or rust streak may show under the head close to the web...

49 CFR 213.113 - Defective rails.

Code of Federal Regulations, 2011 CFR

2011-10-01

... smooth, bright, or dark, round or oval surface substantially at a right angle to the length of the rail... in the head of the rail as a smooth, bright, or dark surface progressing until substantially at a... head, and extending into or through it. A crack or rust streak may show under the head close to the web...

49 CFR 213.113 - Defective rails.

Code of Federal Regulations, 2012 CFR

2012-10-01

... smooth, bright, or dark, round or oval surface substantially at a right angle to the length of the rail... in the head of the rail as a smooth, bright, or dark surface progressing until substantially at a... head, and extending into or through it. A crack or rust streak may show under the head close to the web...

49 CFR 213.113 - Defective rails.

Code of Federal Regulations, 2013 CFR

2013-10-01

... smooth, bright, or dark, round or oval surface substantially at a right angle to the length of the rail... in the head of the rail as a smooth, bright, or dark surface progressing until substantially at a... head, and extending into or through it. A crack or rust streak may show under the head close to the web...

Big Data Analytics and Machine Intelligence Capability Development at NASA Langley Research Center: Strategy, Roadmap, and Progress

NASA Technical Reports Server (NTRS)

Ambur, Manjula Y.; Yagle, Jeremy J.; Reith, William; McLarney, Edward

2016-01-01

In 2014, a team of researchers, engineers and information technology specialists at NASA Langley Research Center developed a Big Data Analytics and Machine Intelligence Strategy and Roadmap as part of Langley's Comprehensive Digital Transformation Initiative, with the goal of identifying the goals, objectives, initiatives, and recommendations need to develop near-, mid- and long-term capabilities for data analytics and machine intelligence in aerospace domains. Since that time, significant progress has been made in developing pilots and projects in several research, engineering, and scientific domains by following the original strategy of collaboration between mission support organizations, mission organizations, and external partners from universities and industry. This report summarizes the work to date in Data Intensive Scientific Discovery, Deep Content Analytics, and Deep Q&A projects, as well as the progress made in collaboration, outreach, and education. Recommendations for continuing this success into future phases of the initiative are also made.

Social inequalities in the face of scientific and technological development: an antinomy or an historic problem?

PubMed

Delgado, Guilherme Costa

2017-07-01

This paper aims to conduct a conceptual analysis of the relationship between scientific and technical progress and social equality, or the reduction of inequalities. We examine this relationship by drawing on three theoretical perspectives: 1) ethical economics, championed by classical economic thinkers and centered on utilitarian self-interest, 2) Mainstream theories of economic development espousing the endogenous link between labor productivity growth and technical progress, 3) the critique of theories of economic development that emerged in the second half of the twentieth century, including Celso Furtado's critique of the theory of underdevelopment, emphasizing the prevalence of egalitarian tendencies, and ecological economics, which suggest alternative paths to those set by "classical" theories of development. The fundamental antinomy posed by the title of this article, characterized by an intrinsic contradiction between technical progress and social equality, strictly presupposes the ethical economics perspective, dominated by the social relations that constitute the "social order".

A Letter to White Women Teachers: An Urgent Plea for Change

ERIC Educational Resources Information Center

Baker, Laura

2017-01-01

The new Progressive Education Network mission says that Progressive Education "promotes diversity, equity, and justice." These goals cannot be met unless there are substantial changes in the way the majority of teachers in the United States, white women teachers, think and operate. This open letter to that audience from a white woman…

Finding the Right Mix: Teaching Methods as Predictors for Student Progress on Learning Objectives

ERIC Educational Resources Information Center

Glover, Jacob I.

2012-01-01

This study extends existing student ratings research by exploring how teaching methods, individually and collectively, influence a minimum standard of student achievement on learning objectives and how class size impacts this influence. Twenty teaching methods were used to predict substantial or exceptional progress on each of 12 learning…

Multidrug-Resistant TB: Implementing the Right to Health through the Right to Enjoy the Benefits of Scientific Progress.

PubMed

London, Leslie; Cox, Helen; Coomans, Fons

2016-06-01

The right to enjoy the benefits of scientific progress (REBSP) is a little-known but potentially valuable right that can contribute to rights-based approaches to addressing multidrug-resistant TB (MDR-TB). We argue that better understanding of the REBSP may help to advance legal and civil society action for health rights. While the REBSP does not provide an individual entitlement to have a new drug developed for MDR-TB, it sets up entitlements to expect a state to establish a legislative and policy framework aimed at developing scientific capacity to address the most important health issues and at disseminating the outcomes of scientific research. By making scientific findings available and accessible, people can be enabled to claim the use of science for social benefits. Inasmuch as the market fails to address neglected diseases such as MDR-TB, the REBSP provides a potential counterbalance to frame a positive obligation on states to both marshal their own resources and to coordinate the actions of multiple other actors towards this goal, including non-state actors. While the latter do not hold the same level of accountability as states, the REBSP can still enable the recognition of obligations at a level of "soft law" responsibilities.

Progressing batch hydrolysis process

DOEpatents

Wright, J.D.

1985-01-10

A progressive batch hydrolysis process is disclosed for producing sugar from a lignocellulosic feedstock. It comprises passing a stream of dilute acid serially through a plurality of percolation hydrolysis reactors charged with feed stock, at a flow rate, temperature and pressure sufficient to substantially convert all the cellulose component of the feed stock to glucose. The cooled dilute acid stream containing glucose, after exiting the last percolation hydrolysis reactor, serially fed through a plurality of pre-hydrolysis percolation reactors, charged with said feedstock, at a flow rate, temperature and pressure sufficient to substantially convert all the hemicellulose component of said feedstock to glucose. The dilute acid stream containing glucose is cooled after it exits the last prehydrolysis reactor.

Progressing batch hydrolysis process

DOEpatents

Wright, John D.

1986-01-01

A progressive batch hydrolysis process for producing sugar from a lignocellulosic feedstock, comprising passing a stream of dilute acid serially through a plurality of percolation hydrolysis reactors charged with said feedstock, at a flow rate, temperature and pressure sufficient to substantially convert all the cellulose component of the feedstock to glucose; cooling said dilute acid stream containing glucose, after exiting the last percolation hydrolysis reactor, then feeding said dilute acid stream serially through a plurality of prehydrolysis percolation reactors, charged with said feedstock, at a flow rate, temperature and pressure sufficient to substantially convert all the hemicellulose component of said feedstock to glucose; and cooling the dilute acid stream containing glucose after it exits the last prehydrolysis reactor.

Drivers and implications of change in global ocean health over the past five years

PubMed Central

Frazier, Melanie; Afflerbach, Jamie; O’Hara, Casey; Katona, Steven; Stewart Lowndes, Julia S.; Jiang, Ning; Pacheco, Erich; Scarborough, Courtney; Polsenberg, Johanna

2017-01-01

Growing international and national focus on quantitatively measuring and improving ocean health has increased the need for comprehensive, scientific, and repeated indicators to track progress towards achieving policy and societal goals. The Ocean Health Index (OHI) is one of the few indicators available for this purpose. Here we present results from five years of annual global assessment for 220 countries and territories, evaluating potential drivers and consequences of changes and presenting lessons learned about the challenges of using composite indicators to measure sustainability goals. Globally scores have shown little change, as would be expected. However, individual countries have seen notable increases or declines due in particular to improvements in the harvest and management of wild-caught fisheries, the creation of marine protected areas (MPAs), and decreases in natural product harvest. Rapid loss of sea ice and the consequent reduction of coastal protection from that sea ice was also responsible for declines in overall ocean health in many Arctic and sub-Arctic countries. The OHI performed reasonably well at predicting near-term future scores for many of the ten goals measured, but data gaps and limitations hindered these predictions for many other goals. Ultimately, all indicators face the substantial challenge of informing policy for progress toward broad goals and objectives with insufficient monitoring and assessment data. If countries and the global community hope to achieve and maintain healthy oceans, we will need to dedicate significant resources to measuring what we are trying to manage. PMID:28678881

Mismatches between 'scientific' and 'non-scientific' ways of knowing and their contributions to public understanding of science.

PubMed

Mikulak, Anna

2011-06-01

As differentiation within scientific disciplines increases, so does differentiation between the sciences and other ways of knowing. This distancing between 'scientific' and 'non-scientific' cultures reflects differences in what are considered valid and reliable approaches to acquiring knowledge and has played a major role in recent science-oriented controversies. Scientists' reluctance to actively engage in science communication, coupled with journalists' reliance on the norms of balance, conflict, and human interest in covering scientific issues, have combined to exacerbate public mistrust of science on issues like the measles-mumps-rubella (MMR) vaccine. The failure of effective communications between scientists and non-scientists has hindered the progress of both effective science and effective policy. In order to better bridge the gap between the 'scientific' and 'non-scientific' cultures, renewed efforts must be made to encourage substantive public engagement, with the ultimate goal of facilitating an open, democratic policy-making process.

[Colciencias and disdain for Colombian scientists: from the Stone Age to the impact factor].

PubMed

Leon-Sarmiento, Fidias E; Bayona-Prieto, Jaime; Bayona, Edgardo; Leon, Martha E

2005-01-01

Writing has dramatically evolved in the world; however, qualification of scientific production in Colombia has not, including the improper use of decree 1444/93 and 1279/02. The last of these decrees authorized Colciencias, the Colombian government institute created to support scientific research in Colombia, to establish rules for its implementation. Colciencias decided to evaluate scientific papers produced in Colombia based on the non-scientific method of the "impact factor", and considered that citations in MEDLINE/PubMed and PsylNFO were second line publications thus violating Colombian law. This affects not only the progress of scientific research in Colombia but also researchers' income and puts Colombia's scientific journals and publications at great disadvantage. Scientific papers indexed in qualified databases such as MEDLINE/PubMed must be judged according to law in order to prevent further injuries to the developing Colombian scientific production.

The removal of Pluto from the class of planets and homosexuality from the class of psychiatric disorders: a comparison.

PubMed

Zachar, Peter; Kendler, Kenneth S

2012-01-13

We compare astronomers' removal of Pluto from the listing of planets and psychiatrists' removal of homosexuality from the listing of mental disorders. Although the political maneuverings that emerged in both controversies are less than scientifically ideal, we argue that competition for "scientific authority" among competing groups is a normal part of scientific progress. In both cases, a complicated relationship between abstract constructs and evidence made the classification problem thorny.

The removal of pluto from the class of planets and homosexuality from the class of psychiatric disorders: a comparison

PubMed Central

2012-01-01

We compare astronomers' removal of Pluto from the listing of planets and psychiatrists' removal of homosexuality from the listing of mental disorders. Although the political maneuverings that emerged in both controversies are less than scientifically ideal, we argue that competition for "scientific authority" among competing groups is a normal part of scientific progress. In both cases, a complicated relationship between abstract constructs and evidence made the classification problem thorny. PMID:22244039

Innovating Science Teacher Education: A History and Philosophy of Science Perspective

ERIC Educational Resources Information Center

Niaz, Mansoor

2010-01-01

How teachers view the nature of scientific knowledge is crucial to their understanding of science content and how it can be taught. This book presents an overview of the dynamics of scientific progress and its relationship to the history and philosophy of science, and then explores their methodological and educational implications and develops…

Progression in Ethical Reasoning When Addressing Socio-Scientific Issues in Biotechnology

ERIC Educational Resources Information Center

Berne, Birgitta

2014-01-01

This article reports on the outcomes of an intervention in a Swedish school in which the author, a teacher-researcher, sought to develop students' (14-15 years old) ethical reasoning in science through the use of peer discussions about socio-scientific issues. Prior to the student discussions various prompts were used to highlight different…

The Concept and Role of Knowledge Worker and Workplace Fit in Learning Organisation

ERIC Educational Resources Information Center

Gaižauskiene, Laura; Tuncikiene, Živile

2016-01-01

The theoretical research was conducted in order to identify the phenomena of "fit", to see its roots and development as well as theoretical progress in the main scientific areas and identify its position in management scientific field. Two elements of the fit model are highlighted: knowledge workers and workplaces in a broad sense. The…

Open access and beyond

PubMed Central

Mathur, Shawn; Schmidt, Christian; Das, Chhaya; Tucker, Philip W

2006-01-01

Uncensored exchange of scientific results hastens progress. Open Access does not stop at the removal of price and permission barriers; still, censorship and reading disabilities, to name a few, hamper access to information. Here, we invite the scientific community and the public to discuss new methods to distribute, store and manage literature in order to achieve unfettered access to literature. PMID:16956402

Open Access and beyond.

PubMed

Mathur, Shawn; Schmidt, Christian; Das, Chhaya; Tucker, Philip W

2006-09-06

Uncensored exchange of scientific results hastens progress. Open Access does not stop at the removal of price and permission barriers; still, censorship and reading disabilities, to name a few, hamper access to information. Here, we invite the scientific community and the public to discuss new methods to distribute, store and manage literature in order to achieve unfettered access to literature.

Publications of the Jet Propulsion Laboratory, 1981

NASA Technical Reports Server (NTRS)

1982-01-01

Over 500 externally distributed technical reports released during 1981 that resulted from scientific and engineering work performed, or managed by Jet Propulsion Laboratory are listed by primary author. Of the total number of entries, 311 are from the bimonthly Deep Space Network Progress Report, and its successor, the Telecommunications and Data Acquisition Progress Report.

On Campus with Women, 1999-2000.

ERIC Educational Resources Information Center

Reiss, Susan, Ed.

2000-01-01

The four issues in this newsletter volume present information on the status and education of women. The focus of issue 1 is women and scientific literacy. Issue 2 contains the lead article, "Progress in Fits and Starts," which concentrates on the progress of women in higher education and trends in enrollment and degree completion. Issue 3 focuses…

REACTOR PHYSICS QUARTERLY REPORT JANUARY, FEBRUARY, MARCH 1970

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmid, L. C.; Clayton, E. D.; Heineman, R. E.

1970-05-01

The objective of the Reactor Physics Quarterly Report is to inform the scientific community in a timely manner of the technical progress made on the many phases of reactor physics work within the laboratory. The report contains brief technical discussions of accomplishments in all areas where significant progress has been made during the quarter.

Innovating aging: promises and pitfalls on the road to life extension

PubMed Central

Vijg, Jan; de Grey, Aubrey D.N.J.

2014-01-01

One of the main benefits from the dramatic technological progress over the last two centuries is the enormous increase in human life expectancy, which has now reached record highs. After conquering most childhood diseases and a fair fraction of the diseases that plague adulthood, medical technology is now mainly pre-occupied by age-related disorders. Further progress is dependent on circumventing the traditional medical focus on individual diseases and instead targeting aging as a whole as the ultimate cause of the health problems that affect humankind at old age. In principle, a major effort to control the gradual accumulation of molecular and cellular damage – considered by many as the ultimate cause of intrinsic aging – may rapidly lead to interventions for regenerating aged and worn-out tissues and organs. While considered impossible by many, there really is no reason to reject this as scientifically implausible. However, as we discuss, it is not only scientific progress that is currently a limiting factor, but societal factors that hinder and may ultimately prevent further progress in testing and adopting the many possible interventions to cure aging. PMID:24732067

Semantic Information Processing of Physical Simulation Based on Scientific Concept Vocabulary Model

NASA Astrophysics Data System (ADS)

Kino, Chiaki; Suzuki, Yoshio; Takemiya, Hiroshi

Scientific Concept Vocabulary (SCV) has been developed to actualize Cognitive methodology based Data Analysis System: CDAS which supports researchers to analyze large scale data efficiently and comprehensively. SCV is an information model for processing semantic information for physics and engineering. In the model of SCV, all semantic information is related to substantial data and algorisms. Consequently, SCV enables a data analysis system to recognize the meaning of execution results output from a numerical simulation. This method has allowed a data analysis system to extract important information from a scientific view point. Previous research has shown that SCV is able to describe simple scientific indices and scientific perceptions. However, it is difficult to describe complex scientific perceptions by currently-proposed SCV. In this paper, a new data structure for SCV has been proposed in order to describe scientific perceptions in more detail. Additionally, the prototype of the new model has been constructed and applied to actual data of numerical simulation. The result means that the new SCV is able to describe more complex scientific perceptions.

Neuromyths in Music Education: Prevalence and Predictors of Misconceptions among Teachers and Students

PubMed Central

Düvel, Nina; Wolf, Anna; Kopiez, Reinhard

2017-01-01

In the last decade, educational neuroscience has become increasingly important in the context of instruction, and its applications have been transformed into new teaching methods. Although teachers are interested in educational neuroscience, communication between scientists and teachers is not always straightforward. Thus, misunderstandings of neuroscientific research results can evolve into so-called neuromyths. The aim of the present study was to investigate the prevalence of such music-related neuromyths among music teachers and music students. Based on an extensive literature research, 26 theses were compiled and subsequently evaluated by four experts. Fourteen theses were selected, of which seven were designated as scientifically substantiated and seven as scientifically unsubstantiated (hereafter labeled as “neuromyths”). One group of adult music teachers (n = 91) and one group of music education students (n = 125) evaluated the theses (forced-choice discrimination task) in two separate online surveys. Additionally, in both surveys person-characteristic variables were gathered to determine possible predictors for the discrimination performance. As a result, identification rates of the seven scientifically substantiated theses were similar for teachers (76%) and students (78%). Teachers and students correctly rejected 60 and 59%, respectively, of the seven neuromyths as scientifically unsubstantiated statements. Sensitivity analysis by signal detection theory revealed a discrimination performance of d' = 1.25 (SD = 1.12) for the group of teachers and d' = 1.48 (SD = 1.22) for the students. Both groups showed a general tendency to evaluate the theses as scientifically substantiated (teachers: c = −0.35, students: c = −0.41). Specifically, buzz words such as “brain hemisphere” or “cognitive enhancement” were often classified as correct. For the group of teachers, the best predictor of discrimination performance was having read a large number of media about educational neuroscience and related topics (R2 = 0.06). For the group of students, the best predictors for discrimination performance were a high number of read media and the hitherto completed number of semesters (R2 = 0.14). Our findings make clear that both teachers and students are far from being experts on topics related to educational neuroscience in music and would therefore benefit from current education-related research in psychology and neuroscience. PMID:28484416

Neuromyths in Music Education: Prevalence and Predictors of Misconceptions among Teachers and Students.

PubMed

Düvel, Nina; Wolf, Anna; Kopiez, Reinhard

2017-01-01

In the last decade, educational neuroscience has become increasingly important in the context of instruction, and its applications have been transformed into new teaching methods. Although teachers are interested in educational neuroscience, communication between scientists and teachers is not always straightforward. Thus, misunderstandings of neuroscientific research results can evolve into so-called neuromyths . The aim of the present study was to investigate the prevalence of such music-related neuromyths among music teachers and music students. Based on an extensive literature research, 26 theses were compiled and subsequently evaluated by four experts. Fourteen theses were selected, of which seven were designated as scientifically substantiated and seven as scientifically unsubstantiated (hereafter labeled as "neuromyths"). One group of adult music teachers ( n = 91) and one group of music education students ( n = 125) evaluated the theses (forced-choice discrimination task) in two separate online surveys. Additionally, in both surveys person-characteristic variables were gathered to determine possible predictors for the discrimination performance. As a result, identification rates of the seven scientifically substantiated theses were similar for teachers (76%) and students (78%). Teachers and students correctly rejected 60 and 59%, respectively, of the seven neuromyths as scientifically unsubstantiated statements. Sensitivity analysis by signal detection theory revealed a discrimination performance of d' = 1.25 ( SD = 1.12) for the group of teachers and d' = 1.48 ( SD = 1.22) for the students. Both groups showed a general tendency to evaluate the theses as scientifically substantiated (teachers: c = -0.35, students: c = -0.41). Specifically, buzz words such as "brain hemisphere" or "cognitive enhancement" were often classified as correct. For the group of teachers, the best predictor of discrimination performance was having read a large number of media about educational neuroscience and related topics ( R 2 = 0.06). For the group of students, the best predictors for discrimination performance were a high number of read media and the hitherto completed number of semesters ( R 2 = 0.14). Our findings make clear that both teachers and students are far from being experts on topics related to educational neuroscience in music and would therefore benefit from current education-related research in psychology and neuroscience.

The Muon Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zisman, Michael S

2010-05-17

We describe the scientific motivation for a new type of accelerator, the muon collider. This accelerator would permit an energy-frontier scientific program and yet would fit on the site of an existing laboratory. Such a device is quite challenging, and requires a substantial R&D program. After describing the ingredients of the facility, the ongoing R&D activities of the Muon Accelerator Program are discussed. A possible U.S. scenario that could lead to a muon collider at Fermilab is briefly mentioned.

The Muon Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zisman, Michael S.

2011-01-05

We describe the scientific motivation for a new type of accelerator, the muon collider. This accelerator would permit an energy-frontier scientific program and yet would fit on the site of an existing laboratory. Such a device is quite challenging, and requires a substantial R&D program. After describing the ingredients of the facility, the ongoing R&D activities of the Muon Accelerator Program are discussed. A possible U.S. scenario that could lead to a muon collider at Fermilab is briefly mentioned.

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death

PubMed Central

1996-01-01

Expression of the bcl-2 gene has been shown to effectively confer resistance to programmed cell death under a variety of circumstances. However, despite a wealth of literature describing this phenomenon, very little is known about the mechanism of resistance. In the experiments described here, we show that bcl-2 gene expression can result in an inhibition of cell division cycle progression. These findings are based upon the analysis of cell cycle distribution, cell cycle kinetics, and relative phosphorylation of the retinoblastoma tumor suppressor protein, using primary tissues in vivo, ex vivo, and in vitro, as well as continuous cell lines. The effects of bcl-2 expression on cell cycle progression appear to be focused at the G1 to S phase transition, which is a critical control point in the decision between continued cell cycle progression or the induction programmed cell death. In all systems tested, bcl-2 expression resulted in a substantial 30-60% increase in the length of G1 phase; such an increase is very substantial in the context of other regulators of cell cycle progression. Based upon our findings, and the related findings of others, we propose a mechanism by which bcl-2 expression might exert its well known inhibition of programmed cell death by regulating the kinetics of cell cycle progression at a critical control point. PMID:8642331

Progress in the RAMI analysis of a conceptual LHCD system for DEMO

NASA Astrophysics Data System (ADS)

Mirizzi, F.

2014-02-01

Reliability, Availability, Maintainability and Inspectability (RAMI) concepts and techniques, that acquired great importance during the first manned space missions, have been progressively extended to industrial, scientific and consumer equipments to assure them satisfactory performances and lifetimes. In the design of experimental facilities, like tokamaks, mainly aimed at demonstrating validity and feasibility of scientific theories, RAMI analysis has been often left aside. DEMO, the future prototype fusion reactors, will be instead designed for steadily delivering electrical energy to commercial grids, so that the RAMI aspects will assume an absolute relevance since their initial design phases. A preliminary RAMI analysis of the LHCD system for the conceptual EU DEMO reactor is given in the paper.

Office of the Chief Financial Officer 2012 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Kim

2013-01-31

Fiscal Year 2012 was a year of progress and change in the Office of the Chief Financial Officer (OCFO) organization. The notable accomplishments outlined below strengthened the quality of the OCFO’s stewardship and services in support of the scientific mission of Lawrence Berkeley National Laboratory (LBNL). Three strategies were key to this progress: organizational transformation aligned with our goals; process redesign and effective use of technology to improve efficiency, and innovative solutions to meet new challenges. Over the next year we will continue to apply these strategies to further enhance our contributions to the Lab’s scientific mission. What follows ismore » the budget, funding and costs for the office for FY 2012.« less

Epistemological pluralism and scientific development: an argument against authoritative nosologies.

PubMed

Markon, Kristian E

2013-10-01

The author examines the influence of authoritative nosological systems--those developed by an authoritative body or organization (e.g., the DSM, ICD, RDoC)--on the development of scientific theory and research. Although there has been extensive discussion of how such systems should be organized, and of the historical role of such systems, little focus has been placed on whether these systems impede or facilitate scientific progress. The author reviews the nature and role of constructs in scientific theory and the role of authoritative taxonomy in science. He presents an argument that, although authoritative classification systems clearly have value for nonscientific purposes, or for specific scientific purposes, the systems themselves, at least as they have been constructed thus far, likely impede scientific development by constraining competitive discourse. Implications and recommendations are discussed.

Enculturating science: Community-centric design of behavior change interactions for accelerating health impact.

PubMed

Kumar, Vishwajeet; Kumar, Aarti; Ghosh, Amit Kumar; Samphel, Rigzin; Yadav, Ranjanaa; Yeung, Diana; Darmstadt, Gary L

2015-08-01

Despite significant advancements in the scientific evidence base of interventions to improve newborn survival, we have not yet been able to "bend the curve" to markedly accelerate global rates of reduction in newborn mortality. The ever-widening gap between discovery of scientific best practices and their mass adoption by families (the evidence-practice gap) is not just a matter of improving the coverage of health worker-community interactions. The design of the interactions themselves must be guided by sound behavioral science approaches such that they lead to mass adoption and impact at a large scale. The main barrier to the application of scientific approaches to behavior change is our inability to "unbox" the "black box" of family health behaviors in community settings. The authors argue that these are not black boxes, but in fact thoughtfully designed community systems that have been designed and upheld, and have evolved over many years keeping in mind a certain worldview and a common social purpose. An empathetic understanding of these community systems allows us to deconstruct the causal pathways of existing behaviors, and re-engineer them to achieve desired outcomes. One of the key reasons for the failure of interactions to translate into behavior change is our failure to recognize that the content, context, and process of interactions need to be designed keeping in mind an organized community system with a very different worldview and beliefs. In order to improve the adoption of scientific best practices by communities, we need to adapt them to their culture by leveraging existing beliefs, practices, people, context, and skills. The authors present a systems approach for community-centric design of interactions, highlighting key principles for achieving intrinsically motivated, sustained change in social norms and family health behaviors, elucidated with progressive theories from systems thinking, management sciences, cross-cultural psychology, learning and social cognition, and the behavioral sciences. These are illustrated through a case study of designing effective interactions in Shivgarh, India, that led to rapid and substantial changes in newborn health behaviors and reduction in NMR by half over a span of 16 months. Copyright © 2015 Elsevier Inc. All rights reserved.

Compartments, Customers, or Convergence?: Evolving Challenges to IT Progress

ERIC Educational Resources Information Center

Jackson, Gregory A.

2007-01-01

For most of the past decade, IT leaders in higher education felt on top of things. Challenges were usually comprehensible and addressable, doing reasonable things yielded reasonable results, and for the most part, IT was a substantial contributor to institutional progress. But these days, IT leaders rarely feel on top of things. Instead, some days…

Evaluating how we evaluate.

PubMed

Vale, Ronald D

2012-09-01

Evaluation of scientific work underlies the process of career advancement in academic science, with publications being a fundamental metric. Many aspects of the evaluation process for grants and promotions are deeply ingrained in institutions and funding agencies and have been altered very little in the past several decades, despite substantial changes that have taken place in the scientific work force, the funding landscape, and the way that science is being conducted. This article examines how scientific productivity is being evaluated, what it is rewarding, where it falls short, and why richer information than a standard curriculum vitae/biosketch might provide a more accurate picture of scientific and educational contributions. The article also explores how the evaluation process exerts a profound influence on many aspects of the scientific enterprise, including the training of new scientists, the way in which grant resources are distributed, the manner in which new knowledge is published, and the culture of science itself.

Science and football: evaluating the influence of science on performance.

PubMed

Drust, B; Green, M

2013-01-01

The scientific study of football has its origins in the early research completed in the 1970's. Since these early efforts the available scientific knowledge base related to football has developed substantially. The ability of this scientific information to influence practice in the day-to-day activity of football organisations, especially elite teams, has been largely taken for granted. The close examination of this impact can lead to more uncertainty regarding the usefulness of the scientific data to the sport. Few articles are available that have attempted to critique the link between science and football practice. As such, the aims of this article are 2-fold; (i) to examine the historical background to "science and football" and to analyse the influence of sports science research on the current practice of coaches and practitioners within the sport and (ii) to identify potential ways to increase the influence of scientific research on practice in the "real world".

Promoting children's agency and communication skills in an informal science program

NASA Astrophysics Data System (ADS)

Wulf, Rosemary; Hinko, Kathleen; Finkelstein, Noah

2013-01-01

The Partnerships for Informal Science Education in the Community (PISEC) program at the University of Colorado Boulder brings together university and community institutions to create an environment where K-12 students join with university educators to engage in inquiry-based scientific practices after school. In our original framing, these afterschool activities were developed to reinforce the traditional learning goals of the classroom, including mastering scientific content, skills and processes. Recently, the primary focus of the PISEC curriculum has been shifted towards the development of students' scientific identity, an explicit objective of informal learning environments. The new curriculum offers students more activity choices, affords opportunities for scientific drawings and descriptions, and provides incentive for students to design their own experiments. We have analyzed student science notebooks from both old and new curricula and find that with the redesigned curriculum, students exhibit increased agency and more instances of scientific communication while still demonstrating substantial content learning gains.

Evaluating how we evaluate

PubMed Central

Vale, Ronald D.

2012-01-01

Evaluation of scientific work underlies the process of career advancement in academic science, with publications being a fundamental metric. Many aspects of the evaluation process for grants and promotions are deeply ingrained in institutions and funding agencies and have been altered very little in the past several decades, despite substantial changes that have taken place in the scientific work force, the funding landscape, and the way that science is being conducted. This article examines how scientific productivity is being evaluated, what it is rewarding, where it falls short, and why richer information than a standard curriculum vitae/biosketch might provide a more accurate picture of scientific and educational contributions. The article also explores how the evaluation process exerts a profound influence on many aspects of the scientific enterprise, including the training of new scientists, the way in which grant resources are distributed, the manner in which new knowledge is published, and the culture of science itself. PMID:22936699

Safe Gene Therapy for Type 1 Diabetes

DTIC Science & Technology

2012-10-01

by transplanting these cells, either alone or together with FoxP3+eGFP+ T-regulatory cells into prediabetic ID-TEC pups. Diabetes incidence and...transplanting these cells, either alone or together with FoxP3+eGFP+ T-regulatory cells into prediabetic ID-TEC pups. Diabetes incidence and progression will...progression of islet-autoimmunity in prediabetic ID-TEC pups. 38 In the fourth quarterly scientific progress report (06/28/11 - 09/27/11) of year 02

A Progressive Reading, Writing, and Artistic Module to Support Scientific Literacy†

PubMed Central

Stockwell, Stephanie B.

2016-01-01

Scientific literacy, marked by the ability and willingness to engage with scientific information, is supported through a new genre of citizen science—course-based research in association with undergraduate laboratories. A three-phased progressive learning module was developed to enhance student engagement in such contexts while supporting three learning outcomes: I) present an argument based on evidence, II) analyze science and scientists within a social context, and III) experience, reflect upon, and communicate the nature of scientific discovery. Phase I entails guided reading and reflection of citizen science–themed texts. In Phase II, students write, peer-review, and edit position and counterpoint papers inspired by the following prompt, “Nonscientists should do scientific research.” Phase III involves two creative assignments intended to communicate the true nature of science. Students work collaboratively to develop public service announcement–like poster campaigns to debunk a common misconception about the nature of science or scientists. Individually, they create a work of art to communicate a specific message about the raw experience of performing scientific research. Suggestions for implementation and modifications are provided. Strengths of the module include the development of transferable skills, temporal distribution of grading demands, minimal in-class time needed for implementation, and the inclusion of artistic projects to support affective learning domains. This citizen science–themed learning module is an excellent complement to laboratory coursework, as it serves to surprise, challenge, and inspire students while promoting disciplinary values. PMID:27047600

Protecting Traditional Knowledge Related to Biological Resources: Is Scientific Research Going to Become More Bureaucratized?

PubMed Central

Reddy, Prashant; Lakshmikumaran, Malathi

2015-01-01

For the past several decades, there has been a world debate on the need for protecting traditional knowledge. A global treaty appears to be a distant reality. Of more immediate concern are the steps taken by the global community to protect access to biological resources in the name of protecting traditional knowledge. The Indian experience with implementing the Convention on Biological Diversity has created substantial legal uncertainty in collaborative scientific research between Indians and foreigners apart from bureaucratizing the entire process of scientific research, especially with regard to filing of applications for intellectual property rights. The issue therefore is whether the world needs to better balance the needs of the scientific community with the rights of those who have access to traditional knowledge. PMID:26101205

Scientific Integrity: The Need for Government Standards

NASA Astrophysics Data System (ADS)

McPhaden, Michael J.

2010-11-01

The U.S. government makes substantial investments in scientific research that address the nation’s need for accurate and authoritative information to guide federal policy decisions. Therefore, there is a lot at stake in having a consistent and explicit federal policy on scientific integrity to increase transparency and build trust in government science. Scientific integrity is an issue that applies not only to individual scientists working within the federal system but also to government agencies in how they use scientific information to formulate policy. The White House issued a memorandum on scientific integrity in March 2009, and it is regrettable that it has taken so much longer than the 120 days stipulated in the president's memo for the release of recommendations by the Office of Science and Technology Policy (OSTP) (see related news item in this issue). While it is also understandable given the welter of different agencies and organizations that make up the executive branch of the government, AGU urges that these recommendations be finalized and published as soon as possible.

Quantifying the Ease of Scientific Discovery

PubMed Central

Arbesman, Samuel

2012-01-01

It has long been known that scientific output proceeds on an exponential increase, or more properly, a logistic growth curve. The interplay between effort and discovery is clear, and the nature of the functional form has been thought to be due to many changes in the scientific process over time. Here I show a quantitative method for examining the ease of scientific progress, another necessary component in understanding scientific discovery. Using examples from three different scientific disciplines – mammalian species, chemical elements, and minor planets – I find the ease of discovery to conform to an exponential decay. In addition, I show how the pace of scientific discovery can be best understood as the outcome of both scientific output and ease of discovery. A quantitative study of the ease of scientific discovery in the aggregate, such as done here, has the potential to provide a great deal of insight into both the nature of future discoveries and the technical processes behind discoveries in science. PMID:22328796

Quantifying the Ease of Scientific Discovery.

PubMed

Arbesman, Samuel

2011-02-01

It has long been known that scientific output proceeds on an exponential increase, or more properly, a logistic growth curve. The interplay between effort and discovery is clear, and the nature of the functional form has been thought to be due to many changes in the scientific process over time. Here I show a quantitative method for examining the ease of scientific progress, another necessary component in understanding scientific discovery. Using examples from three different scientific disciplines - mammalian species, chemical elements, and minor planets - I find the ease of discovery to conform to an exponential decay. In addition, I show how the pace of scientific discovery can be best understood as the outcome of both scientific output and ease of discovery. A quantitative study of the ease of scientific discovery in the aggregate, such as done here, has the potential to provide a great deal of insight into both the nature of future discoveries and the technical processes behind discoveries in science.

Progress in The Semantic Analysis of Scientific Code

NASA Technical Reports Server (NTRS)

Stewart, Mark

2000-01-01

This paper concerns a procedure that analyzes aspects of the meaning or semantics of scientific and engineering code. This procedure involves taking a user's existing code, adding semantic declarations for some primitive variables, and parsing this annotated code using multiple, independent expert parsers. These semantic parsers encode domain knowledge and recognize formulae in different disciplines including physics, numerical methods, mathematics, and geometry. The parsers will automatically recognize and document some static, semantic concepts and help locate some program semantic errors. These techniques may apply to a wider range of scientific codes. If so, the techniques could reduce the time, risk, and effort required to develop and modify scientific codes.

Future Sky Surveys: New Discovery Frontiers

NASA Astrophysics Data System (ADS)

Tyson, J. Anthony; Borne, Kirk D.

2012-03-01

Driven by the availability of new instrumentation, there has been an evolution in astronomical science toward comprehensive investigations of new phenomena. Major advances in our understanding of the Universe over the history of astronomy have often arisen from dramatic improvements in our capability to observe the sky to greater depth, in previously unexplored wavebands, with higher precision, or with improved spatial, spectral, or temporal resolution. Substantial progress in the important scientific problems of the next decade (determining the nature of dark energy and dark matter, studying the evolution of galaxies and the structure of our own Milky Way, opening up the time domain to discover faint variable objects, and mapping both the inner and outer Solar System) can be achieved through the application of advanced data mining methods and machine learning algorithms operating on the numerous large astronomical databases that will be generated from a variety of revolutionary future sky surveys. Over the next decade, astronomy will irrevocably enter the era of big surveys and of really big telescopes. New sky surveys (some of which will produce petabyte-scale data collections) will begin their operations, and one or more very large telescopes (ELTs = Extremely Large Telescopes) will enter the construction phase. These programs and facilities will generate a remarkable wealth of data of high complexity, endowed with enormous scientific knowledge discovery potential. New parameter spaces will be opened, in multiple wavelength domains as well as the time domain, across wide areas of the sky, and down to unprecedented faint source flux limits. The synergies of grand facilities, massive data collections, and advanced machine learning algorithms will come together to enable discoveries within most areas of astronomical science, including Solar System, exo-planets, star formation, stellar populations, stellar death, galaxy assembly, galaxy evolution, quasar evolution, and cosmology. Current and future sky surveys, comprising an alphabet soup of project names (e.g., Pan- STARRS, WISE, Kepler, DES, VST, VISTA, GAIA, EUCLID, SKA, LSST, and WFIRST; some of which are discussed in Chapters 17, 18, and 20),will contribute to the exponential explosion of complex data in astronomy. The scientific goals of these projects are as monumental as the programs themselves. The core scientific output of all of these will be their scientific data collection. Consequently, data mining and machine learning algorithms and specialists will become a common component of future astronomical research with these facilities. This synergistic combination and collaboration among multiple disciplines are essential in order to maximize the scientific discovery potential, the science output, the research efficiency, and the success of these projects.

Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba

PubMed Central

Fransen, Heidi P.; Pelgrom, Sylvia M.G.J.; Stewart-Knox, Barbara; de Kaste, Dries; Verhagen, Hans

2010-01-01

Background European Regulation 1924/2006 states that all health claims made on foods need to be substantiated scientifically. Objective To apply the PASSCLAIM criteria for the scientific substantiation of health claims on foods to herbal supplements containing Ginkgo biloba. Evaluation of three selected claimed health effects for G. biloba (improvement of blood circulation, improvement of symptoms of old age, and improvement of memory) was achieved through review of publicly available scientific data. A total of 35 human intervention studies were evaluated. Commercially available products claimed to contain mainly G. biloba (N=29) were randomly sampled in the Netherlands and analyzed for their content on ginkgo extract. Also, a toxicological risk assessment was performed. Results The three selected health claims investigated could not be substantiated. This was mainly because of a lack of data from studies in healthy volunteers. In most studies results performed with a 24% standardized G. biloba extract were described. However, our chemical analysis showed that 25 of the 29 sampled products did not contain the required minimum 24% standardized extract. Moreover, in most preparations the content of substances typical for G. biloba did not conform to what was declared on the label. Since toxicity data for G. biloba are very limited, a safety limit could not be established. Conclusions Evidence is lacking for three health claims of herbal products with G. biloba. Neither safety nor efficacy can be guaranteed at the recommended daily dose. The multidisciplinary approach described in this paper provides good insight into issues that are relevant for the evaluation of health claims for herbal food supplements. PMID:20927202

Gamification and Transmedia for Scientific Promotion and for Encouraging Scientific Careers in Adolescents

ERIC Educational Resources Information Center

Pérez-Manzano, Antonio; Almela-Baeza, Javier

2018-01-01

The current growth in gamification-based applications, and especially in what is known as Digital Game-based Learning (DGBL), is providing new opportunities with considerable educational potential. In the present study, we report on the results of the progress of a project for developing a setting for a gamified website carried out ad hoc,…

Debates—Hypothesis testing in hydrology: Theory and practice

NASA Astrophysics Data System (ADS)

Pfister, Laurent; Kirchner, James W.

2017-03-01

The basic structure of the scientific method—at least in its idealized form—is widely championed as a recipe for scientific progress, but the day-to-day practice may be different. Here, we explore the spectrum of current practice in hypothesis formulation and testing in hydrology, based on a random sample of recent research papers. This analysis suggests that in hydrology, as in other fields, hypothesis formulation and testing rarely correspond to the idealized model of the scientific method. Practices such as "p-hacking" or "HARKing" (Hypothesizing After the Results are Known) are major obstacles to more rigorous hypothesis testing in hydrology, along with the well-known problem of confirmation bias—the tendency to value and trust confirmations more than refutations—among both researchers and reviewers. Nonetheless, as several examples illustrate, hypothesis tests have played an essential role in spurring major advances in hydrological theory. Hypothesis testing is not the only recipe for scientific progress, however. Exploratory research, driven by innovations in measurement and observation, has also underlain many key advances. Further improvements in observation and measurement will be vital to both exploratory research and hypothesis testing, and thus to advancing the science of hydrology.

Scientific and Technological Progress, Political Beliefs and Environmental Sustainability

ERIC Educational Resources Information Center

Makrakis, Vassilios

2012-01-01

With the development of science and technology, a basically optimistic ideology of progress has emerged. This deterministic attitude has been challenged in recent decades as a result of harmful side-effects generated by the way technology and science have been approached and used. The study presented here is a part of a larger international and…

Open scientific communication urged

NASA Astrophysics Data System (ADS)

Richman, Barbara T.

In a report released last week the National Academy of Sciences' Panel on Scientific Communication and National Security concluded that the ‘limited and uncertain benefits’ of controls on the dissemination of scientific and technological research are ‘outweighed by the importance of scientific progress, which open communication accelerates, to the overall welfare of the nation.’ The 18-member panel, chaired by Dale R. Corson, president emeritus of Cornell University, was created last spring (Eos, April 20, 1982, p. 241) to examine the delicate balance between open dissemination of scientific and technical information and the U.S. government's desire to protect scientific and technological achievements from being translated into military advantages for our political adversaries.The panel dealt almost exclusively with the relationship between the United States and the Soviet Union but noted that there are ‘clear problems in scientific communication and national security involving Third World countries.’ Further study of this matter is necessary.

GMOs in Russia: Research, Society and Legislation.

PubMed

Korobko, I V; Georgiev, P G; Skryabin, K G; Kirpichnikov, M P

2016-01-01

Russian legislation lags behind the rapid developments witnessed in genetic engineering. Only a scientifically based and well-substantiated policy on the place of organisms that are created with the use of genetic engineering technologies and an assessment of the risks associated with them could guarantee that the breakthroughs achieved in modern genetic engineering technologies are effectively put to use in the real economy. A lack of demand for such breakthroughs in the practical field will lead to stagnation in scientific research and to a loss of expertise.

Rooftop Runoff as a Source of Contamination: A Review

EPA Science Inventory

Scientific reports concerning chemical and microbiological contaminant levels of rainwater runoff from rooftop collection in both urban and rural areas are reviewed. This alternative source of water has been documented to often contain substantial amounts of contaminants. Studi...

Scheduling Earth Observing Fleets Using Evolutionary Algorithms: Problem Description and Approach

NASA Technical Reports Server (NTRS)

Globus, Al; Crawford, James; Lohn, Jason; Morris, Robert; Clancy, Daniel (Technical Monitor)

2002-01-01

We describe work in progress concerning multi-instrument, multi-satellite scheduling. Most, although not all, Earth observing instruments currently in orbit are unique. In the relatively near future, however, we expect to see fleets of Earth observing spacecraft, many carrying nearly identical instruments. This presents a substantially new scheduling challenge. Inspired by successful commercial applications of evolutionary algorithms in scheduling domains, this paper presents work in progress regarding the use of evolutionary algorithms to solve a set of Earth observing related model problems. Both the model problems and the software are described. Since the larger problems will require substantial computation and evolutionary algorithms are embarrassingly parallel, we discuss our parallelization techniques using dedicated and cycle-scavenged workstations.

What Drives Academic Data Sharing?

PubMed Central

Fecher, Benedikt; Friesike, Sascha; Hebing, Marcel

2015-01-01

Despite widespread support from policy makers, funding agencies, and scientific journals, academic researchers rarely make their research data available to others. At the same time, data sharing in research is attributed a vast potential for scientific progress. It allows the reproducibility of study results and the reuse of old data for new research questions. Based on a systematic review of 98 scholarly papers and an empirical survey among 603 secondary data users, we develop a conceptual framework that explains the process of data sharing from the primary researcher’s point of view. We show that this process can be divided into six descriptive categories: Data donor, research organization, research community, norms, data infrastructure, and data recipients. Drawing from our findings, we discuss theoretical implications regarding knowledge creation and dissemination as well as research policy measures to foster academic collaboration. We conclude that research data cannot be regarded as knowledge commons, but research policies that better incentivise data sharing are needed to improve the quality of research results and foster scientific progress. PMID:25714752

Sustainable growth, the DuPont way.

PubMed

Holliday, C

2001-09-01

Like many manufacturers, DuPont traditionally has grown by making more and more "stuff." And its business growth has been proportional to the amount of raw materials and energy used--as well as the resulting waste and emissions from operations. Over the years, though, DuPont became aware that cheap supplies of nonrenewable resources wouldn't be endlessly available and that the earth's ecosystems couldn't indefinitely absorb the waste and emissions of production and consumption. Chad Holliday, chairman and CEO of DuPont, believes strongly in the challenge of sustainable growth and makes the business case for it: By using creativity and scientific knowledge effectively, he says, companies can provide strong returns for shareholders and grow their businesses--while also meeting the human needs of societies around the world and reducing the environmental footprint of their operations and products. In fact, a focus on sustainability can help identify new products, markets, partnerships, and intellectual property and lead to substantial business growth. Holliday describes how DuPont developed a three-pronged strategy to translate the concept of sustainability into nuts-and-bolts business practices. Focusing on integrated science, knowledge intensity, and productivity improvement, the strategy was accompanied by a new way to measure progress quantitatively. Sustainable growth should be viewed not as a program for stepped-up environmental performance but as a comprehensive way of doing business, one that delivers tremendous economic value and opens up new opportunities. Ultimately, companies will find that they can generate substantial business value through sustainability while both enhancing the quality of life around the world and protecting the environment.

Radioisotope fueled pulsed power generation system for propulsion and electrical power for deep space missions

NASA Astrophysics Data System (ADS)

Howe, Troy

Space exploration missions to the moon, Mars, and other celestial bodies have allowed for great scientific leaps to enhance our knowledge of the universe; yet the astronomical cost of these missions limits their utility to only a few select agencies. Reducing the cost of exploratory space travel will give rise to a new era of exploration, where private investors, universities, and world governments can send satellites to far off planets and gather important data. By using radioisotope power sources and thermal storage devices, a duty cycle can be introduced to extract large amounts of energy in short amounts of time, allowing for efficient space travel. The same device can also provide electrical power for subsystems such as communications, drills, lasers, or other components that can provide valuable scientific information. This project examines the use of multiple radioisotope sources combined with a thermal capacitor using Phase Change Materials (PCMs) which can collect energy over a period of time. The result of this design culminates in a variety of possible spacecraft with their own varying costs, transit times, and objectives. Among the most promising are missions to Mars which cost less than 17M, missions that can provide power to satellite constellations for decades, or missions that can deliver large, Opportunity-sized (185kg) payloads to mars for less than 53M. All made available to a much wider range of customer with commercially available satellite launches from earth. The true cost of such progress though lies in the sometimes substantial increase in transit times for these missions.

Measuring progress in nursing and midwifery globally.

PubMed

al-Gasseer, Naeema; Persaud, Vena

2003-01-01

To discuss issues and challenges encountered in the preliminary steps of identifying a core set of global indicators for measuring progress in nursing and midwifery development. Lack of a global and systematic approach for collecting evidence has undermined the ability to reliably measure progress. Description of general principles, scientific criteria, and strategic directions. WHO's organizational support and global conditions are forces that indicated appropriate timing for these strategic directions. Concerted efforts are needed in all countries to implement these directions to advance nursing and midwifery services.

Nutritionally enhanced crops and food security: scientific achievements versus political expediency.

PubMed

Farre, Gemma; Twyman, Richard M; Zhu, Changfu; Capell, Teresa; Christou, Paul

2011-04-01

Genetic engineering (GE) is one of a raft of strategies that can be used to tackle malnutrition. Recent scientific advances have shown that multiple deficiencies can be tackled simultaneously using engineered plant varieties containing high levels of different minerals and organic nutrients. However, the impact of this progress is being diluted by the unwillingness of politicians to see beyond immediate popular support, favoring political expediency over controversial but potentially life-saving decisions based on rational scientific evidence. Copyright © 2010 Elsevier Ltd. All rights reserved.

[History of the German Society of Oromaxillofacial Surgery].

PubMed

Schwenzer, N

2000-05-01

The German Society of Oral and Maxillofacial Surgery was founded by Martin Wassmund in 1951. One of the main reasons was the need for scientific representation in the council at a medical convention. The Society, originally composed of 52 members, was first called "The German Society of Maxillofacial Surgery". In 1972, it extended its title to include the term "oral" ("Mund") and currently comprises 620 members. A scientific conference is held annually on a specific topic. The lectures given there have been published since 1954 in "Fortschritte der Kiefer- und Gesichts-Chirurgie" (Progress in Maxillofacial Surgery) by Thieme Verlag; since 1997, they have appeared as a Springer-Verlag supplement. Topics of choice are published in "Mund-, Kiefer- und Gesichtschirurgie" ("Oral and Maxillofacial Surgery"), originally by Hanser in Munich and now by Springer-Verlag in Heidelberg. In this manner, it was possible to completely document the scientific activities and progress in this specialty. Each year since 1957, a prize named after M. Wassmund, has been given for outstanding scientific accomplishment. The presidents, convention locations, topics, and prizewinners are listed in a table. Since the founding of the Society of Oral and Maxillofacial Surgery, close cooperation has existed with the National Association of German Oral and Maxillary-Facial Surgeons (Bundesverband der Deutschen Arzte für Mund-Kiefer-Gesichts-Chirurgie). In order to intertwine scientific and political interests, a fusion of these two organizations is planned for the year 2000.

The regulation of patient-reported outcome claims: need for a flexible standard.

PubMed

Morris, Louis A; Miller, David W

2002-01-01

We review the FDA's policies for the regulation of patient-reported outcome (PRO) claims such as quality of life, productivity, satisfaction and symptom reports and suggest alternative standards for substantiation. We base our review on FDA regulatory activities and public statements in the field of advertising substantiation. We compare these activities to the FDA's label substantiation policies and policies for health-economic (HE) claim substantiation. There is an overt inconsistency between the FDA's policies for substantiation of PRO claims in product labels and substantiation for such claims in advertising materials. This results in a higher standard for PRO claims in promotional vehicles than in product labels. Rather than relying on a "substantial evidence" standard, the FDA should consider a more flexible standard, such as the one currently applied to information included in the Clinical Trials section of product labels, or adopting a "competent and reliable scientific evidence" standard as set forth in Section 114 of the Food and Drug Administration Modernization Act (FDAMA) for HE data. We conclude that there needs to be greater consistency for substantiation in product labels and promotional materials. Furthermore, reconceptualizing most PRO claims as benefit extrapolations as opposed to efficacy information suggests a less rigorous standard is necessary.

Progress in Application of the Neurosciences to an Understanding of Human Learning: The Challenge of Finding a Middle-Ground Neuroeducational Theory

ERIC Educational Resources Information Center

Anderson, O. Roger

2014-01-01

Modern neuroscientific research has substantially enhanced our understanding of the human brain. However, many challenges remain in developing a strong, brain-based theory of human learning, especially in complex environments such as educational settings. Some of the current issues and challenges in our progress toward developing comprehensive…

Progress and Challenges in Subseasonal Prediction

NASA Technical Reports Server (NTRS)

Schubert, Siegfried

2003-01-01

While substantial advances have occurred over the last few decades in both weather and seasonal prediction, progress in improving predictions on subseasonal time scales (approximately 2 weeks to 2 months) has been slow. In this talk I will highlight some of the recent progress that has been made to improve forecasts on subseasonal time scales and outline the challenges that we face both from an observational and modeling perspective. The talk will be based primarily on the results and conclusions of a recent NASA-sponsored workshop that focused on the subseasonal prediction problem. One of the key conclusions of that workshop was that there is compelling evidence for predictability at forecast lead times substantially longer than two weeks, and that much of that predictability is currently untapped. Tropical diabatic heating and soil wetness were singled out as particularly important processes affecting predictability on these time scales. Predictability was also linked to various low-frequency atmospheric phenomena such as the annular modes in high latitudes (including their connections to the stratosphere), the Pacific/North American pattern, and the Madden-Julian Oscillation. I will end the talk by summarizing the recommendations and plans that have been put forward for accelerating progress on the subseasonal prediction problem.

[The current state and prospect of Chinese medicine gastroenterology].

PubMed

Zhang, Sheng-Sheng; Zhou, Tao

2012-03-01

The progress and existent problems of Chinese medicine (CM) gastroenterology since the National Eleventh Five-Year Plan were discussed in this article in terms of theory innovation, formulation of clinical pathway and diagnosis-treatment consensus, efficacy assessment, formulation of efficacy assessment scale, advantage diseases, and exploration of the syndrome standardization, progress in science research, academic exchange, and the construction of study platform, and so on. Meanwhile, the development of CM gastroenterology was prospected in the following five aspects: to enhance the theory inheritance and innovation, the construction of discipline standardization; to establish scientific clinical efficacy assessment methods and the standard system; to expend treatment technologies and feature therapies; and to clarify the modern scientific connotation of CM theory and treatment.

CHRONICLE: Third International Symposium on Modern Optics, Budapest, September 1988

NASA Astrophysics Data System (ADS)

Bukhenskiĭ, M. F.; Nikitin, P. I.; Semenov, A. S.

1989-07-01

The Third International Symposium on Modern Optics (Optics-88), held in Budapest on 13-16 September 1988, was organized by the Hungarian Optical, Acoustic, and Cinematographic Society with the support of the International Commission on Optics and various scientific and industrial organizations in Hungary. The International Symposium Committee was composed of leading specialists from 11 countries in Asia, America, and Europe with A. M. Prokhorov (USSR) and N. Kroo (Hungary) as Co-chairmen. The purpose of this regular symposium is to summarize the scientific and technical progress underlying the developments in optics itself, discuss the branches of science where progress depends on optical methods in devices, and draw the attention of specialists to the most promising trends which should yield results in the immediate future.

The concept of intelligibility in modern physics (1948).

PubMed

Feyerabend, Paul K

2016-06-01

This is an English translation of Paul Feyerabend's earliest extant essay "Der Begriff der Verständlichkeit in der modernen Physik" (1948). In it, Feyerabend defends positivism as a progressive framework for scientific research in certain stages of scientific development. He argues that in physics visualizability (Anschaulichkeit) and intelligibility (Verständlichkeit) are time-conditioned concepts: what is deemed visualizable in the development of physical theories is relative to a specific historical context and changes over time. He concludes that from time to time the abandonment of visualizability is crucial for progress in physics, as it is conducive to major theory change, illustrating the point on the basis of advances in atomic theory. Copyright © 2015 Elsevier Ltd. All rights reserved.

Self-organization of progress across the century of physics

NASA Astrophysics Data System (ADS)

Perc, Matjaž

2013-04-01

We make use of information provided in the titles and abstracts of over half a million publications that were published by the American Physical Society during the past 119 years. By identifying all unique words and phrases and determining their monthly usage patterns, we obtain quantifiable insights into the trends of physics discovery from the end of the 19th century to today. We show that the magnitudes of upward and downward trends yield heavy-tailed distributions, and that their emergence is due to the Matthew effect. This indicates that both the rise and fall of scientific paradigms is driven by robust principles of self-organization. Data also confirm that periods of war decelerate scientific progress, and that the later is very much subject to globalisation.

Delimiting the Unconceived

NASA Astrophysics Data System (ADS)

Dawid, Richard

2018-01-01

It has been argued in Dawid (String theory and the scientific method, Cambridge University Press, Cambridge, [4]) that physicists at times generate substantial trust in an empirically unconfirmed theory based on observations that lie beyond the theory's intended domain. A crucial role in the reconstruction of this argument of "non-empirical confirmation" is played by limitations to scientific underdetermination. The present paper discusses the question as to how generic the role of limitations to scientific underdetermination really is. It is argued that assessing such limitations is essential for generating trust in any theory's predictions, be it empirically confirmed or not. The emerging view suggests that empirical and non-empirical confirmation are more closely related to each other than one may expect at first glance.

Delimiting the Unconceived

NASA Astrophysics Data System (ADS)

Dawid, Richard

2018-05-01

It has been argued in Dawid (String theory and the scientific method, Cambridge University Press, Cambridge, [4]) that physicists at times generate substantial trust in an empirically unconfirmed theory based on observations that lie beyond the theory's intended domain. A crucial role in the reconstruction of this argument of "non-empirical confirmation" is played by limitations to scientific underdetermination. The present paper discusses the question as to how generic the role of limitations to scientific underdetermination really is. It is argued that assessing such limitations is essential for generating trust in any theory's predictions, be it empirically confirmed or not. The emerging view suggests that empirical and non-empirical confirmation are more closely related to each other than one may expect at first glance.

POLICY AND SCIENCE IN NATURAL RESOURCE AGENCIES: SEARCHING FOR APPROPRIATE ROLES

EPA Science Inventory

Effectively resolving natural resource, ecological, and environmental policy problems often requires substantial input from scientists. The value of scientific information for informing policy deliberations is reduced when what is offered as "science" is inculcated with policy p...

Nature contact and human health: A research agenda

Treesearch

Howard Frumkin; Gregory N. Bratman; Sara Jo Breslow; Bobby Cochran; Peter H. Kahn Jr; Joshua J. Lawler; Phillip S. Levin; Pooja S. Tandon; Usha Varanasi; Kathleen L. Wolf; Spencer A. Wood

2017-01-01

BACKGROUND: At a time of increasing disconnectedness from nature, scientific interest in the potential health benefits of nature contact has grown. Research in recent decades has yielded substantial evidence, but large gaps remain in our understanding. OBJECTIVES: We propose a research...

JPRS Report, Science & Technology, Japan, 1987 S&T Paper

DTIC Science & Technology

1988-08-26

council recommended in its report increasing the amount of subsidies for scientific research, vitalizing the scientific research systems at...activities that have recently been progressing in Japan. Greatest importance was attached to "the development of an effective means of preventing cancer...natter COKPENDEX (Engineering —Civil enginsering, environmental eng, —Hetal, resource eng —Hechanical eng. —ChBnical, agric . eng —Agricultural, nana

Redressing the inverted pyramid of scientific publishing

NASA Astrophysics Data System (ADS)

Caux, Jean-Sébastien

2017-11-01

Scientific publishing is currently undergoing a progressively rapid transformation away from the traditional subscription model. With the Open Access movement in full swing, existing business practices and future plans are coming under increasing scrutiny, while new "big deals" are being made at breakneck speed. Scientists can rightfully ask themselves if all these changes are going the right way, and if not, what can be done about it.

How can we enhance girls' interest in scientific topics?

PubMed

Kerger, Sylvie; Martin, Romain; Brunner, Martin

2011-12-01

Girls are considerably less interested in scientific subjects than boys. One reason may be that scientific subjects are considered to be genuinely masculine. Thus, being interested in science may threaten the self-perception of girls as well as the femininity of their self-image. If scientific topics that are considered to be stereotypically feminine were chosen, however, this potential threat might be overcome which, in turn, might lead to an increase in girls' interest in science. This hypothesis was empirically tested by means of two studies. Participants were 294 (Study 1) and 190 (Study 2) Grade 8 to Grade 9 students. Gender differences in students' interest in masculine and feminine topics were investigated for a range of scientific concepts (Study 1) as well as for a given scientific concept (Study 2) for four scientific subjects (i.e., biology, physics, information technology, and statistics), respectively. Both studies indicated that the mean level of girls' scientific interest was higher when scientific concepts were presented in the context of feminine topics and boys' level of scientific interests was higher when scientific concepts were presented in the context of masculine topics. Girls' interest in science could be substantially increased by presenting scientific concepts in the context of feminine topics. Gender differences as well as individual differences in the level of interest in scientific topics may be taken into account by creating learning environments in which students could select the context in which a certain scientific concept is embedded. ©2011 The British Psychological Society.

Developing a Learning Progression for Sea Level Rise, a Major Impact of Climate Change

ERIC Educational Resources Information Center

Breslyn, Wayne; McGinnis, J. Randy; McDonald, R. Christopher; Hestness, Emily

2016-01-01

We present research from an investigation on developing a learning progression (LP) for sea level rise (SLR), a major effect of global climate change. We began our research by drafting a hypothetical LP for sea level rise, informed by extant knowledge of the topic in the scientific community, in science education literature, and in science…

Developing an Initial Learning Progression for the Use of Evidence in Decision-Making Contexts

ERIC Educational Resources Information Center

Bravo-Torija, Beatriz; Jiménez-Aleixandre, María-Pilar

2018-01-01

This paper outlines an initial learning progression for the use of evidence to support scientific arguments in the context of decision-making. Use of evidence is a central feature of knowledge evaluation and, therefore, of argumentation. The proposal is based on the literature on argumentation and use of evidence in decision-making contexts. The…

News & Views Evaluation of Projects for Basic Research of Scientific Instruments in 2008 Completed NSFC Former President Tang Ao-qing Passed Away Professor Tang Aoqing and NSFC Carbon Nanotube Film-Based Speaker Developed in Tsinghua University Dinosaur Footprint Fossils Discovered in Xinjiang New Method for Early Cancer Diagnosis New Progress Achieved by NSFC Project in Basic Research of Black Hole Physics New progress in Organic FET 67 NSFC-RFBR Cooperative Projects Approved for 2008 Spin Configuration and Super-exchange Mechanism in Molecular Magnets Observed NSFC Strengthens its Funding in Wenchuan Concerns Go to Disaster's Impact on Economy and Emergency Response Thirty-seven NSFC-KOSEF Cooperative Projects Approved

NASA Astrophysics Data System (ADS)

2008-01-01

Evaluation of Projects for Basic Research of Scientific Instruments in 2008 Completed NSFC Former President Tang Ao-qing Passed Away Professor Tang Aoqing and NSFC Carbon Nanotube Film-Based Speaker Developed in Tsinghua University Dinosaur Footprint Fossils Discovered in Xinjiang New Method for Early Cancer Diagnosis New Progress Achieved by NSFC Project in Basic Research of Black Hole Physics New progress in Organic FET 67 NSFC-RFBR Cooperative Projects Approved for 2008 Spin Configuration and Super-exchange Mechanism in Molecular Magnets Observed NSFC Strengthens its Funding in Wenchuan Concerns Go to Disaster's Impact on Economy and Emergency Response Thirty-seven NSFC-KOSEF Cooperative Projects Approved

Protecting Traditional Knowledge Related to Biological Resources: Is Scientific Research Going to Become More Bureaucratized?

PubMed

Reddy, Prashant; Lakshmikumaran, Malathi

2015-06-22

For the past several decades, there has been a world debate on the need for protecting traditional knowledge. A global treaty appears to be a distant reality. Of more immediate concern are the steps taken by the global community to protect access to biological resources in the name of protecting traditional knowledge. The Indian experience with implementing the Convention on Biological Diversity has created substantial legal uncertainty in collaborative scientific research between Indians and foreigners apart from bureaucratizing the entire process of scientific research, especially with regard to filing of applications for intellectual property rights. The issue therefore is whether the world needs to better balance the needs of the scientific community with the rights of those who have access to traditional knowledge. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

Characterising the progress in HIV/AIDS research in the Middle East and North Africa

PubMed Central

Saba, Hanan F; Kouyoumjian, Silva P; Mumtaz, Ghina R; Abu-Raddad, Laith J

2013-01-01

Objectives The Middle East and North Africa (MENA) region is perceived to have limited HIV data. The objective of this study was to quantitatively characterise the progress in HIV research in this region since the discovery of the epidemic. Methods Four indices were defined and implemented to measure the progress of HIV research using the PubMed, Embase, MENA HIV/AIDS Epidemiology Synthesis Project and US Census Bureau HIV/AIDS Surveillance databases. The four indices provide complementary measures to characterise different aspects of the progress of HIV research. Results A total of 2118, 2352, 683 and 4889 records were identified through the PubMed, the Embase, the Synthesis Project and the HIV Prevalence indices, respectively. The proportion of the total global HIV records that relate to MENA is 1.2%. Overall, the indices show steady progress in the number of new records every year, with an accelerated pace in the last few years. The rate of progress in MENA was also higher than the rate of progress in HIV records globally. There is no evidence so far of stabilisation or a peak in the number of new records year by year. About half of the records were produced after the year 2005. The number of records shows large heterogeneity across countries. Conclusions MENA has witnessed a rapid growth in HIV research over the last decade. However, there are still large gaps in HIV scientific evidence in the region, and the progress is far from being uniform across countries. Ongoing and future research needs to be geared towards academic standard and production of scientific publications. PMID:23596206

Teaching Scientific Reasoning to Liberal Arts Students

NASA Astrophysics Data System (ADS)

Rubbo, Louis

2014-03-01

University courses in conceptual physics and astronomy typically serve as the terminal science experience for the liberal arts student. Within this population significant content knowledge gains can be achieved by utilizing research verified pedagogical methods. However, from the standpoint of the Univeristy, students are expected to complete these courses not necessarily for the content knowledge but instead for the development of scientific reasoning skills. Results from physics education studies indicate that unless scientific reasoning instruction is made explicit students do not progress in their reasoning abilities. How do we complement the successful content based pedagogical methods with instruction that explicitly focuses on the development of scientific reasoning skills? This talk will explore methodologies that actively engages the non-science students with the explicit intent of fostering their scientific reasoning abilities.

Space Weather Forecasting: An Enigma

NASA Astrophysics Data System (ADS)

Sojka, J. J.

2012-12-01

The space age began in earnest on October 4, 1957 with the launch of Sputnik 1 and was fuelled for over a decade by very strong national societal concerns. Prior to this single event the adverse effects of space weather had been registered on telegraph lines as well as interference on early WWII radar systems, while for countless eons the beauty of space weather as mid-latitude auroral displays were much appreciated. These prior space weather impacts were in themselves only a low-level science puzzle pursued by a few dedicated researchers. The technology boost and innovation that the post Sputnik era generated has almost single handedly defined our present day societal technology infrastructure. During the decade following Neil's walk on the moon on July 21, 1969 an international thrust to understand the science of space, and its weather, was in progress. However, the search for scientific understand was parsed into independent "stove pipe" categories: The ionosphere-aeronomy, the magnetosphere, the heliosphere-sun. The present day scientific infrastructure of funding agencies, learned societies, and international organizations are still hampered by these 1960's logical divisions which today are outdated in the pursuit of understanding space weather. As this era of intensive and well funded scientific research progressed so did societies innovative uses for space technologies and space "spin-offs". Well over a decade ago leaders in technology, science, and the military realized that there was indeed an adverse side to space weather that with each passing year became more severe. In 1994 several U.S. agencies established the National Space Weather Program (NSWP) to focus scientific attention on the system wide issue of the adverse effects of space weather on society and its technologies. Indeed for the past two decades a significant fraction of the scientific community has actively engaged in understanding space weather and hence crossing the "stove-pipe" disciplines. The perceived progress in space weather understanding differs significantly depending upon which community (scientific, technology, forecaster, society) is addressing the question. Even more divergent are these thoughts when the question is how valuable is the scientific capability of forecasting space weather. This talk will discuss present day as well as future potential for forecasting space weather for a few selected examples. The author will attempt to straddle the divergent community opinions.

[How to prepare a poster presentation].

PubMed

Cerezal Pesquera, L

2013-06-01

Scientific and educational poster presentations in national and international meetings are one of the most effective means of scientific communication. Poster presentations are of particular importance in a mainly visual speciality like radiology, and also play a significant role in continuing medical education in our specialty. However, poster should be no more than an intermediate step on the way to publish our work in a scientific journal. The publication rates of posters prented in courses and conferences is very low in our country. Therefore, we must continue to progress in training in scientific publication, with efforts such as this supplement. This article review how to create an effective poster presentation. Copyright © 2013 SERAM. Published by Elsevier Espana. All rights reserved.

Primary progressive aphasia: a clinical approach.

PubMed

Marshall, Charles R; Hardy, Chris J D; Volkmer, Anna; Russell, Lucy L; Bond, Rebecca L; Fletcher, Phillip D; Clark, Camilla N; Mummery, Catherine J; Schott, Jonathan M; Rossor, Martin N; Fox, Nick C; Crutch, Sebastian J; Rohrer, Jonathan D; Warren, Jason D

2018-06-01

The primary progressive aphasias are a heterogeneous group of focal 'language-led' dementias that pose substantial challenges for diagnosis and management. Here we present a clinical approach to the progressive aphasias, based on our experience of these disorders and directed at non-specialists. We first outline a framework for assessing language, tailored to the common presentations of progressive aphasia. We then consider the defining features of the canonical progressive nonfluent, semantic and logopenic aphasic syndromes, including 'clinical pearls' that we have found diagnostically useful and neuroanatomical and other key associations of each syndrome. We review potential diagnostic pitfalls and problematic presentations not well captured by conventional classifications and propose a diagnostic 'roadmap'. After outlining principles of management, we conclude with a prospect for future progress in these diseases, emphasising generic information processing deficits and novel pathophysiological biomarkers.

Micronutrients, N-Acetyl Cysteine, Probiotics and Prebiotics, a Review of Effectiveness in Reducing HIV Progression

PubMed Central

Hummelen, Ruben; Hemsworth, Jaimie; Reid, Gregor

2010-01-01

Low serum concentrations of micronutrients, intestinal abnormalities, and an inflammatory state have been associated with HIV progression. These may be ameliorated by micronutrients, N-acetyl cysteine, probiotics, and prebiotics. This review aims to integrate the evidence from clinical trials of these interventions on the progression of HIV. Vitamin B, C, E, and folic acid have been shown to delay the progression of HIV. Supplementation with selenium, N-acetyl cysteine, probiotics, and prebiotics has considerable potential, but the evidence needs to be further substantiated. Vitamin A, iron, and zinc have been associated with adverse effects and caution is warranted for their use. PMID:22254046

Policy Issues for Education in General Agriculture in UK Universities.

ERIC Educational Resources Information Center

Whittemore, C. T.

1996-01-01

At present, substantial research funding for agriculture departments in British research universities is not forthcoming. Present policies could widen the divide between pure and applied sciences and between scientific education for agricultural scientists and technical education for agricultural generalists. (SK)

A transdisciplinary approach to developing an eastern broccoli industry

USDA-ARS?s Scientific Manuscript database

Current economic, social and scientific situations have made it attractive to establish a substantial and profitable broccoli industry in the eastern US, where several obstacles have prevented that from happening previously. Because many barriers must be overcome simultaneously, we assembled a tran...

Fallout from Nuclear Tests.

ERIC Educational Resources Information Center

Comar, C. L.

This booklet, in the series "Understanding the Atom," summarizes the important findings on radioactive fallout for which there is substantial scientific agreement, indicates the areas of disagreement, and lists some answered questions. Sources of fallout, its local and worldwide effects (including movement in the atmosphers), the…

Science for the Public Good: Tackling scientific integrity in the federal government

NASA Astrophysics Data System (ADS)

Goldman, G. T.; Halpern, M.; Johnson, C.

2016-12-01

From hydraulic fracturing to climate change to seismic risk, government science and scientists are integral to public decision making in the geosciences. Following calls for increased scientific integrity across the government, policies have been put in place in recent years to be promote transparency and appropriate use of science in government decision making. But how effective have these initiatives been? With the development of scientific integrity policies, new transparency measures, and other efforts in recent years, are we seeing improvements in how federal agencies use science? And importantly, can these safeguards prevent potential future breaches of scientific integrity and misuse science for political gain? Review of recent progress and problems around government scientific integrity, including case studies, policy assessments, and surveys of federal scientists, can shed light on how far the we have come and what areas still need improvement to ensure that government scientific integrity is preserved in the future.

Early Rockets

NASA Image and Video Library

2004-04-15

Dr. Robert H. Goddard loading a 1918 version of the Bazooka of World War II. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

The Unfulfilled Promise of Special Education: The Transition from Education to Work for Young Adults with Disabilities

ERIC Educational Resources Information Center

Rusch, Frank R.; Loomis, Frederick D.

2005-01-01

During the past quarter century, federal legislation has resulted in fundamental changes in the way youth with special needs are educated. Despite legal mandates and substantial funding support, only minimal progress has been made in the rate at which exceptional children progress through school to the world of work. During the past 30 years,…

Designing Unmanned Systems with Greater Autonomy: Using a Federated, Partially Open Systems Architecture Approach

DTIC Science & Technology

2014-01-01

system UAV unmanned aircraft vehicle UCI User -Computer Interface UCS UAS control segment Abbreviations xxix UGS unmanned ground system UGV unmanned ...made substantial progress in the deployment of more capable sensors, unmanned aircraft systems (UAS), and other unmanned systems (UxS). Innovative...progress in fielding more, and more capable unmanned aircraft systems (UAS) to meet the needs of warfighters

Programmatic Research to Develop and Disseminate Improved Instructional Technology for Handicapped Children. Project MORE Quarterly Progress Report, September 1 to December 1, 1972.

ERIC Educational Resources Information Center

Schiefelbusch, Richard L.; Lent, James R.

During the past reporting period the curriculum development staff of Project MORE (Mediated Operational Research for Education) has made substantial progress in attaining its program objectives. Design and development phases have proceeded on schedule. Four programs are currently in the field-testing stage, and four others are under development.…

Maternal and neonatal tetanus

PubMed Central

Thwaites, C Louise; Beeching, Nicholas J; Newton, Charles R

2017-01-01

Maternal and neonatal tetanus is still a substantial but preventable cause of mortality in many developing countries. Case fatality from these diseases remains high and treatment is limited by scarcity of resources and effective drug treatments. The Maternal and Neonatal Tetanus Elimination Initiative, launched by WHO and its partners, has made substantial progress in eliminating maternal and neonatal tetanus. Sustained emphasis on improvement of vaccination coverage, birth hygiene, and surveillance, with specific approaches in high-risk areas, has meant that the incidence of the disease continues to fall. Despite this progress, an estimated 58 000 neonates and an unknown number of mothers die every year from tetanus. As of June, 2014, 24 countries are still to eliminate the disease. Maintenance of elimination needs ongoing vaccination programmes and improved public health infrastructure. PMID:25149223

Progression in Ethical Reasoning When Addressing Socio-scientific Issues in Biotechnology

NASA Astrophysics Data System (ADS)

Berne, Birgitta

2014-11-01

This article reports on the outcomes of an intervention in a Swedish school in which the author, a teacher-researcher, sought to develop students' (14-15 years old) ethical reasoning in science through the use of peer discussions about socio-scientific issues. Prior to the student discussions various prompts were used to highlight different aspects of the issues. In addition, students were given time to search for further information themselves. Analysis of students' written arguments, from the beginning of the intervention and afterwards, suggests that many students seem to be moving away from their use of everyday language towards using scientific concepts in their arguments. In addition, they moved from considering cloning and 'designer babies' solely in terms of the present to considering them in terms of the future. Furthermore, the students started to approach the issues in additional ways using not only consequentialism but also the approaches of virtue ethics, and rights and duties. Students' progression in ethical reasoning could be related to the characteristics of the interactions in peer discussions as students who critically and constructively argued with each other's ideas, and challenged each other's claims, made progress in more aspects of ethical reasoning than students merely using cumulative talk. As such, the work provides valuable indications for the importance of introducing peer discussions and debates about SSIs in connection to biotechnology into the teaching of science in schools.

Personalized Medicine for Chronic Respiratory Infectious Diseases: Tuberculosis, Nontuberculous Mycobacterial Pulmonary Diseases, and Chronic Pulmonary Aspergillosis.

PubMed

Salzer, Helmut J F; Wassilew, Nasstasja; Köhler, Niklas; Olaru, Ioana D; Günther, Gunar; Herzmann, Christian; Kalsdorf, Barbara; Sanchez-Carballo, Patricia; Terhalle, Elena; Rolling, Thierry; Lange, Christoph; Heyckendorf, Jan

2016-01-01

Chronic respiratory infectious diseases are causing high rates of morbidity and mortality worldwide. Tuberculosis, a major cause of chronic pulmonary infection, is currently responsible for approximately 1.5 million deaths per year. Although important advances in the fight against tuberculosis have been made, the progress towards eradication of this disease is being challenged by the dramatic increase in multidrug-resistant bacilli. Nontuberculous mycobacteria causing pulmonary disease and chronic pulmonary aspergillosis are emerging infectious diseases. In contrast to other infectious diseases, chronic respiratory infections share the trait of having highly variable treatment outcomes despite longstanding antimicrobial therapy. Recent scientific progress indicates that medicine is presently at a transition stage from programmatic to personalized management. We explain current state-of-the-art management concepts of chronic pulmonary infectious diseases as well as the underlying methods for therapeutic decisions and their implications for personalized medicine. Furthermore, we describe promising biomarkers and techniques with the potential to serve future individual treatment concepts in this field of difficult-to-treat patients. These include candidate markers to improve individual risk assessment for disease development, the design of tailor-made drug therapy regimens, and individualized biomarker-guided therapy duration to achieve relapse-free cure. In addition, the use of therapeutic drug monitoring to reach optimal drug dosing with the smallest rate of adverse events as well as candidate agents for future host-directed therapies are described. Taken together, personalized medicine will provide opportunities to substantially improve the management and treatment outcome of difficult-to-treat patients with chronic respiratory infections. © 2016 S. Karger AG, Basel.

Subtyping stuttering I: a review.

PubMed

Yairi, Ehud

2007-01-01

A reliable and practical subtype system of stuttering should enhance all related scientific work concerned with this disorder. Although a fair number of classification systems have been offered, to date, none has received wide recognition or has been routinely applied in research or clinical spheres. Whereas progress has been made in understanding and treating the disorder, for the most part stuttering continues to be viewed and addressed as a unitary problem. The objectives of the current article are to (a) highlight the motivation for identifying sub-types of stuttering, (b) outline the issues involved in researching subtypes, and (c) address the question of whether or not subtyping is plausible for this disorder. Toward these ends, a broad-based review of past concepts regarding subtypes of stuttering and stutterers is presented according to seven categories that reflect the various authors' conceptual or experimental approaches. Selected studies for each category are also presented to illustrate the research problems and challenges. It is concluded that islands of progress can be identified in subtype research, particularly in studies of children. It is recommended that future studies include multiple factors or domains in the data collection process, especially with young children during the formative years of the disorder, when substantial overlap in the development of several speech/language domains occurs. (a) Readers will be able to describe the theory and research concerning the numerous attempts to subtype stuttering, particularly during the past 50 years; (b) Readers will be able to explain the general issues that need to be resolved in order to identify subtypes as well as current and future research strategies aimed at achieving these goals.

Evolving Relevance of Neuroproteomics in Alzheimer's Disease.

PubMed

Lista, Simone; Zetterberg, Henrik; O'Bryant, Sid E; Blennow, Kaj; Hampel, Harald

2017-01-01

Substantial progress in the understanding of the biology of Alzheimer's disease (AD) has been achieved over the past decades. The early detection and diagnosis of AD and other age-related neurodegenerative diseases, however, remain a challenging scientific frontier. Therefore, the comprehensive discovery (relating to all individual, converging or diverging biochemical disease mechanisms), development, validation, and qualification of standardized biological markers with diagnostic and prognostic functions with a precise performance profile regarding specificity, sensitivity, and positive and negative predictive value are warranted.Methodological innovations in the area of exploratory high-throughput technologies, such as sequencing, microarrays, and mass spectrometry-based analyses of proteins/peptides, have led to the generation of large global molecular datasets from a multiplicity of biological systems, such as biological fluids, cells, tissues, and organs. Such methodological progress has shifted the attention to the execution of hypothesis-independent comprehensive exploratory analyses (opposed to the classical hypothesis-driven candidate approach), with the aim of fully understanding the biological systems in physiology and disease as a whole. The systems biology paradigm integrates experimental biology with accurate and rigorous computational modelling to describe and foresee the dynamic features of biological systems. The use of dynamically evolving technological platforms, including mass spectrometry, in the area of proteomics has enabled to rush the process of biomarker discovery and validation for refining significantly the diagnosis of AD. Currently, proteomics-which is part of the systems biology paradigm-is designated as one of the dominant matured sciences needed for the effective exploratory discovery of prospective biomarker candidates expected to play an effective role in aiding the early detection, diagnosis, prognosis, and therapy development in AD.

Southern African Large Telescope (SALT) project: progress and status after 2 years

NASA Astrophysics Data System (ADS)

Meiring, Jacobus G.; Buckley, David A. H.; Lomberg, Michael C.; Stobie, Robert S.

2003-02-01

The Southern African Large Telescope (SALT) is a 10-m class optical/IR segmented mirror telescope based on the groundbreaking, low cost, Hobby-Eberly Telescope (HET) design. Approval to construct and operate SALT, which will be the largest single optical telescope in the Southern Hemisphere, was given by the South African Government in November 1999, after sufficient guarantees of matching funding from international partners were secured. Facility construction started in January 2001, and SALT is due to start operations by December 2004. SALT will enable a quantum leap in astronomical research capability in Southern Africa, and indeed the continent, where currently the largest telescope is a modest 1.9-m, dating to the 1940s. A substantial amount of design work for SALT has been completed, sourced from multiple suppliers, with ~60% South African content. South African industry is well equipped to handle the construction of most of the telescope, the exceptions being the glass ceramic mirror blanks (from LZOS in Russia), the polishing and ion figuring of these (Eastman Kodak in the USA), and fabrication of the four-element spherical aberration corrector (SAGEM in France). This paper will present (1) the scientific requirements, (2) the specified performance of SALT, (3) the basic design, with emphasis on the innovative modifications to the HET design that enable significantly improved performance, (4) the progress and status of the project, currently in its construction phase, (5) the first generation instrument suite, (6) the management and organisation of the project and (7) the international partnership in SALT.

Promoting Knowledge Creation Discourse in an Asian Primary Five Classroom: Results from an inquiry into life cycles

NASA Astrophysics Data System (ADS)

van Aalst, Jan; Sioux Truong, Mya

2011-03-01

The phrase 'knowledge creation' refers to the practices by which a community advances its collective knowledge. Experience with a model of knowledge creation could help students to learn about the nature of science. This research examined how much progress a teacher and 16 Primary Five (Grade 4) students in the International Baccalaureate Primary Years Programme could make towards the discourse needed for Bereiter and Scardamalia's model of knowledge creation. The study consisted of two phases: a five-month period focusing on the development of the classroom ethos and skills needed for this model (Phase 1), followed by a two-month inquiry into life cycles (Phase 2). In Phase 1, we examined the classroom practices that are thought to support knowledge creation and the early experiences of the students with a web-based inquiry environment, Knowledge Forum®. In Phase 2, we conducted a summative evaluation of the students' work in Knowledge Forum in the light of the model. The data sources included classroom video recordings, artefacts of the in-class work, the Knowledge Forum database, a science content test, questionnaires, and interviews. The findings indicate that the students made substantial progress towards the knowledge creation discourse, particularly regarding the social structure of this kind of discourse and, to a lesser extent, its idea-centred nature. They also made acceptable advances in scientific knowledge and appeared to enjoy this way of learning. The study provides one of the first accounts in the literature of how a teacher new to the knowledge creation model enacted it in an Asian primary classroom.

Solid-state optical refrigeration to sub-100 Kelvin regime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Melgaard, Seth D.; Albrecht, Alexander R.; Hehlen, Markus P.

We report that since the first demonstration of net cooling twenty years ago, optical refrigeration of solids has progressed to outperform all other solid-state cooling processes. It has become the first and only solid-state refrigerator capable of reaching cryogenic temperatures, and now the first solid-state cooling below 100 K. Such substantial progress required a multi-disciplinary approach of pump laser absorption enhancement, material characterization and purification, and thermal management. Here we present the culmination of two decades of progress, the record cooling to ≈91K from room temperature.

Solid-state optical refrigeration to sub-100 Kelvin regime

DOE PAGES

Melgaard, Seth D.; Albrecht, Alexander R.; Hehlen, Markus P.; ...

2016-02-05

We report that since the first demonstration of net cooling twenty years ago, optical refrigeration of solids has progressed to outperform all other solid-state cooling processes. It has become the first and only solid-state refrigerator capable of reaching cryogenic temperatures, and now the first solid-state cooling below 100 K. Such substantial progress required a multi-disciplinary approach of pump laser absorption enhancement, material characterization and purification, and thermal management. Here we present the culmination of two decades of progress, the record cooling to ≈91K from room temperature.

Extended-range tiltable micromirror

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, James J; Wiens, Gloria J; Bronson, Jessica R

A tiltable micromirror device is disclosed in which a micromirror is suspended by a progressive linkage with an electrostatic actuator (e.g. a vertical comb actuator or a capacitive plate electrostatic actuator) being located beneath the micromirror. The progressive linkage includes a pair of torsion springs which are connected together to operate similar to a four-bar linkage with spring joints. The progressive linkage provides a non-linear spring constant which can allow the micromirror to be tilted at any angle within its range substantially free from any electrostatic instability or hysteretic behavior.

Solid-state optical refrigeration to sub-100 Kelvin regime

PubMed Central

Melgaard, Seth D.; Albrecht, Alexander R.; Hehlen, Markus P.; Sheik-Bahae, Mansoor

2016-01-01

Since the first demonstration of net cooling twenty years ago, optical refrigeration of solids has progressed to outperform all other solid-state cooling processes. It has become the first and only solid-state refrigerator capable of reaching cryogenic temperatures, and now the first solid-state cooling below 100 K. Such substantial progress required a multi-disciplinary approach of pump laser absorption enhancement, material characterization and purification, and thermal management. Here we present the culmination of two decades of progress, the record cooling to ≈ 91 K from room temperature. PMID:26847703

Artificial intelligence and deep learning - Radiology's next frontier?

PubMed

Mayo, Ray Cody; Leung, Jessica

Tracing the use of computers in the radiology department from administrative functions through image acquisition, storage, and reporting, to early attempts at improved diagnosis, we begin to imagine possible new frontiers for their use in exam interpretation. Given their initially slow but ultimately substantial progress in the noninterpretive areas, we are left desiring and even expecting more in the interpretation realm. New technological advances may provide the next wave of progress and radiologists should be early adopters. Several potential applications are discussed and hopefully will serve to inspire future progress. Published by Elsevier Inc.

About | DOepatents

Science.gov Websites

demonstrate the Department's contribution to scientific progress in the physical sciences and other in the physical sciences in the United States. Our mission is to advance science and sustain

Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.

PubMed

Cheng, Susan; Shah, Svati H; Corwin, Elizabeth J; Fiehn, Oliver; Fitzgerald, Robert L; Gerszten, Robert E; Illig, Thomas; Rhee, Eugene P; Srinivas, Pothur R; Wang, Thomas J; Jain, Mohit

2017-04-01

Through the measure of thousands of small-molecule metabolites in diverse biological systems, metabolomics now offers the potential for new insights into the factors that contribute to complex human diseases such as cardiovascular disease. Targeted metabolomics methods have already identified new molecular markers and metabolomic signatures of cardiovascular disease risk (including branched-chain amino acids, select unsaturated lipid species, and trimethylamine- N -oxide), thus in effect linking diverse exposures such as those from dietary intake and the microbiota with cardiometabolic traits. As technologies for metabolomics continue to evolve, the depth and breadth of small-molecule metabolite profiling in complex systems continue to advance rapidly, along with prospects for ongoing discovery. Current challenges facing the field of metabolomics include scaling throughput and technical capacity for metabolomics approaches, bioinformatic and chemoinformatic tools for handling large-scale metabolomics data, methods for elucidating the biochemical structure and function of novel metabolites, and strategies for determining the true clinical relevance of metabolites observed in association with cardiovascular disease outcomes. Progress made in addressing these challenges will allow metabolomics the potential to substantially affect diagnostics and therapeutics in cardiovascular medicine. © 2017 American Heart Association, Inc.

Rethinking Environmental Protection: Meeting the Challenges of a Changing World.

PubMed

Burke, Thomas A; Cascio, Wayne E; Costa, Daniel L; Deener, Kacee; Fontaine, Thomas D; Fulk, Florence A; Jackson, Laura E; Munns, Wayne R; Orme-Zavaleta, Jennifer; Slimak, Michael W; Zartarian, Valerie G

2017-03-01

From climate change to hydraulic fracturing, and from drinking water safety to wildfires, environmental challenges are changing. The United States has made substantial environmental protection progress based on media-specific and single pollutant risk-based frameworks. However, today’s environmental problems are increasingly complex and new scientific approaches and tools are needed to achieve sustainable solutions to protect the environment and public health. In this article, we present examples of today’s environmental challenges and offer an integrated systems approach to address them. We provide a strategic framework and recommendations for advancing the application of science for protecting the environment and public health. We posit that addressing 21st century challenges requires transdisciplinary and systems approaches, new data sources, and stakeholder partnerships. To address these challenges, we outline a process driven by problem formulation with the following steps: a ) formulate the problem holistically, b ) gather and synthesize diverse information, c ) develop and assess options, and d ) implement sustainable solutions. This process will require new skills and education in systems science, with an emphasis on science translation. A systems-based approach can transcend media- and receptor-specific bounds, integrate diverse information, and recognize the inextricable link between ecology and human health.

The influence of meteorological conditions on the progress and dynamics of pollen phenophases of selected species.

NASA Astrophysics Data System (ADS)

Jatczak, K.; Linkowska, J.; Rapiejko, P.

2010-09-01

In Poland phenological data is used mainly as a natural indicator of the influence of climate changes on environment. In relation to the growing interest of phenology in scientific research, we substantially extended observation ranges, concentrating mainly on phenophases of selected species that are important for allergology. Phenological data application in complex analysis together with meteorological and aerobiological data, give an opportunity for drawing conclusions on variability of the starting date of pollen season and its dynamics in a meteorological aspect. Species have their regional phenological characteristics, however the characteristics depends on meteorological conditions in a particular year. Therefore, the calculation of pheno-meteorological parameters is important for pollen release prediction. Availability of phenological database can also be useful in the field of preventive health care, through phenological data application in different atmospheric models (NWP models, phenological models, pollen release models) for numerical forecasting of pollen concentration in the air. Genetic conditions, industrial development, increase of air pollution are regarded as the main determinants of allergic diseases. The results of pheno - aero- meteorological analysis enable the estimation of the influence of natural environmental changes on the increasing prevalence of allergic diseases in Poland.

2D/2D graphitic carbon nitride (g-C3N4) heterojunction nanocomposites for photocatalysis: Why does face-to-face interface matter?

NASA Astrophysics Data System (ADS)

Ong, Wee-Jun

2017-04-01

In recent years, two-dimensional (2D) graphitic carbon nitride (g-C3N4) has elicited interdisciplinary research fascination among the scientific communities due to its attractive properties such as appropriate band structures, visible-light absorption, and high chemical and thermal stability. At present, research aiming at engineering 2D g-C3N4 photocatalysts at an atomic and molecular level in conquering the global energy demand and environmental pollution has been thriving. In this review, the cutting-edge research progress on the 2D/2D g-C3N4-based hybrid nanoarchitectures will be systematically highlighted with a specific emphasis on a multitude of photocatalytic applications, not only in waste degradation for pollution alleviation, but also in renewable energy production (e.g. water splitting and carbon dioxide (CO2) reduction). By reviewing the substantial developments on this hot research platform, it is envisioned that the review will shed light and pave a new prospect for constructing high photocatalytic performance of 2D/2D g-C3N4-based system, which could also be extended to other related energy fields, namely solar cells, supercapacitors and electrocatalysis.

Improving Outcome of Psychosocial Treatments by Enhancing Memory and Learning

PubMed Central

Harvey, Allison G.; Lee, Jason; Williams, Joseph; Hollon, Steven D.; Walker, Matthew P.; Thompson, Monique A.; Smith, Rita

2014-01-01

Mental disorders are prevalent and lead to significant impairment. Progress toward establishing treatments has been good. However, effect sizes are small to moderate, gains may not persist, and many patients derive no benefit. Our goal is to highlight the potential for empirically-supported psychosocial treatments to be improved by incorporating insights from cognitive psychology and research on education. Our central question is: If it were possible to improve memory for content of sessions of psychosocial treatments, would outcome substantially improve? This question arises from five lines of evidence: (a) mental illness is often characterized by memory impairment, (b) memory impairment is modifiable, (c) psychosocial treatments often involve the activation of emotion, (d) emotion can bias memory and (e) memory for psychosocial treatment sessions is poor. Insights from scientific knowledge on learning and memory are leveraged to derive strategies for a transdiagnostic and transtreatment cognitive support intervention. These strategies can be applied within and between sessions and to interventions delivered via computer, the internet and text message. Additional novel pathways to improving memory include improving sleep, engaging in exercise and imagery. Given that memory processes change across the lifespan, services to children and older adults may benefit from cognitive support. PMID:25544856

Invited review: improving feed efficiency in dairy production: challenges and possibilities.

PubMed

Connor, E E

2015-03-01

Despite substantial advances in milk production efficiency of dairy cattle over the last 50 years, rising feed costs remain a significant threat to producer profitability. There also is a greater emphasis being placed on reducing the negative impacts of dairy production on the environment; thus means to lower greenhouse gas (GHG) emissions and nutrient losses to the environment associated with cattle production are being sought. Improving feed efficiency among dairy cattle herds offers an opportunity to address both of these issues for the dairy industry. However, the best means to assess feed efficiency and make genetic progress in efficiency-related traits among lactating cows without negatively impacting other economically important traits is not entirely obvious. In this review, multiple measurements of feed efficiency for lactating cows are described, as well as the heritability of the traits and their genetic and phenotypic correlations with other production traits. The measure of feed efficiency, residual feed intake is discussed in detail in terms of the benefits for its selection, how it could be assessed in large commercial populations, as well as biological mechanisms contributing to its variation among cows, as it has become a commonly used method to estimate efficiency in the recent scientific literature.

Managing Rheumatoid Arthritis with Dietary Interventions

PubMed Central

Khanna, Shweta; Jaiswal, Kumar Sagar; Gupta, Bhawna

2017-01-01

Self-help by means of dietary interventions can help in management of various disorders including rheumatoid arthritis (RA), a debilitating autoimmune disease. Dietary interventions necessitate a widespread appeal for both patients as well as clinicians due to factors including affordability, accessibility, and presence of scientific evidences that demonstrate substantial benefits in reducing disease symptoms such as pain, joint stiffness, swelling, tenderness and associated disability with disease progression. However, there is still an uncertainty among the community about the therapeutic benefits of dietary manipulations for RA. In the present review, we provide an account of different diets and their possible molecular mechanism of actions inducing observed therapeutic benefits for remission and management of RA. We further indicate food that can be a potential aggravating factor for the disease or may help in symptomatic relief. We thereafter summarize and thereby discuss various diets and food which help in reducing levels of inflammatory cytokines in RA patients that may play an effective role in management of RA following proper patient awareness. We thus would like to promote diet management as a tool that can both supplement and complement present treatment strategies for a better patient health and recovery. PMID:29167795

Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group.

PubMed

Laubach, J; Garderet, L; Mahindra, A; Gahrton, G; Caers, J; Sezer, O; Voorhees, P; Leleu, X; Johnsen, H E; Streetly, M; Jurczyszyn, A; Ludwig, H; Mellqvist, U-H; Chng, W-J; Pilarski, L; Einsele, H; Hou, J; Turesson, I; Zamagni, E; Chim, C S; Mazumder, A; Westin, J; Lu, J; Reiman, T; Kristinsson, S; Joshua, D; Roussel, M; O'Gorman, P; Terpos, E; McCarthy, P; Dimopoulos, M; Moreau, P; Orlowski, R Z; Miguel, J S; Anderson, K C; Palumbo, A; Kumar, S; Rajkumar, V; Durie, B; Richardson, P G

2016-05-01

The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM.

Heterogeniety and Heterarchy: How far can network analyses in Earth and space sciences?

NASA Astrophysics Data System (ADS)

Prabhu, A.; Fox, P. A.; Eleish, A.; Li, C.; Pan, F.; Zhong, H.

2017-12-01

The vast majority of explorations of Earth systems are limited in their ability to effectively explore the most important (often most difficult) problems because they are forced to interconnect at the data-element, or syntactic, level rather than at a higher scientific, or conceptual/ semantic, level. Recent successes in the application of complex network theory and algorithms to minerology, fossils and proteins over billions of years of Earth's history, raise expectations that more general graph-based approaches offer the opportunity for new discoveries = needles instead of haystacks. In the past 10 years in the natural sciences there has substantial progress in providing both specialists and non-specialists the ability to describe in machine readable form, geophysical quantities and relations among them in meaningful and natural ways, effectively breaking the prior syntax barrier. The corresponding open-world semantics and reasoning provide higher-level interconnections. That is, semantics provided around the data structures, using open-source tools, allow for discovery at the knowledge level. This presentation will cover the fundamentals of data-rich network analyses for geosciences, provide illustrative examples in mineral evolution and offer future paths for consideration.

Rethinking Environmental Protection: Meeting the Challenges of a Changing World

PubMed Central

Burke, Thomas A.; Cascio, Wayne E.; Costa, Daniel L.; Deener, Kacee; Fontaine, Thomas D.; Fulk, Florence A.; Jackson, Laura E.; Munns, Wayne R.; Orme-Zavaleta, Jennifer; Slimak, Michael W.; Zartarian, Valerie G.

2017-01-01

Summary: From climate change to hydraulic fracturing, and from drinking water safety to wildfires, environmental challenges are changing. The United States has made substantial environmental protection progress based on media-specific and single pollutant risk-based frameworks. However, today’s environmental problems are increasingly complex and new scientific approaches and tools are needed to achieve sustainable solutions to protect the environment and public health. In this article, we present examples of today’s environmental challenges and offer an integrated systems approach to address them. We provide a strategic framework and recommendations for advancing the application of science for protecting the environment and public health. We posit that addressing 21st century challenges requires transdisciplinary and systems approaches, new data sources, and stakeholder partnerships. To address these challenges, we outline a process driven by problem formulation with the following steps: a) formulate the problem holistically, b) gather and synthesize diverse information, c) develop and assess options, and d) implement sustainable solutions. This process will require new skills and education in systems science, with an emphasis on science translation. A systems-based approach can transcend media- and receptor-specific bounds, integrate diverse information, and recognize the inextricable link between ecology and human health. PMID:28248180

The helical ventricular myocardial band of Torrent-Guasp.

PubMed

Kocica, Mladen J; Corno, Antonio F; Lackovic, Vesna; Kanjuh, Vladimir I

2007-01-01

We live in an era of substantial progress in understanding myocardial structure and function at genetic, molecular, and microscopic levels. Yet, ventricular myocardium has proven remarkably resistant to macroscopic analyses of functional anatomy. Pronounced and practically indefinite global and local structural anisotropy of its fibers and other ventricular wall constituents produces electrical and mechanical properties that are nonlinear, anisotropic, time varying, and spatially inhomogeneous. The helical ventricular myocardial band of Torrent-Guasp is a revolutionary new concept in understanding global, 3-dimensional, functional architecture of the ventricular myocardium. This concept defines the principal, cumulative vectors, integrating the tissue architecture (ie, form) and net forces developed (ie, function) within the ventricular mass. The primary purpose of this review is to emphasize the importance of this concept, in the light of collaborative efforts to establish an integrative approach, defining ventricular form and function by linking across multiple scales of biological organization, as explained in the ongoing Physiome project. Because one of the most important scientific missions in this century is integration of basic research with clinical medicine, we believe that this knowledge is not of merely academic importance, but is also the essential prerequisite in clinical evaluation and treatment of different heart diseases.

Plagiarism: an egregious form of misconduct.

PubMed

Juyal, Deepak; Thawani, Vijay; Thaledi, Shweta

2015-02-01

Publishing research papers for academic fraternity has become important for career advancement and promotion. Number of publications in peer reviewed journals and subsequent citations are recognized as measures of scientific success. Non-publishing academicians and researchers are invisible to the scientific community. With pressure to publish, misconduct has crept into scientific writing with the result that research misconduct, plagiarism, misappropriation of intellectual property, and substantial unattributed textual copying of another's publication have become common. The Office of Research Integrity, USA, defines research misconduct as "fabrication, falsification or plagiarism in proposing, performing or reviewing research, or in reporting research results." Although plagiarism is difficult to define in few words, it can be viewed as the stealing of another person's ideas, methods, results, or words without giving proper attribution. The Office of Research Integrity defines plagiarism as being "theft or misappropriation of intellectual property and the substantial unattributed textual copying of another's work." Plagiarism is one of the most vehemently derided breaches of research integrity as it undermines the original and honest contribution to an existing body of knowledge. Plagiarism has many forms viz. blatant plagiarism, technical plagiarism, patchwork plagiarism, and self-plagiarism. In any form, the plagiarism is a threat to the research integrity and is unacceptable. We do need to detect such acts and effectively prosecute the offenders.

Uncertainty as Impetus for Climate Mitigation

NASA Astrophysics Data System (ADS)

Lewandowsky, S.; Oreskes, N.; Risbey, J.

2015-12-01

For decades, the scientific community has called for actions to be taken to mitigate the adverse consequences of climate change. To date, those calls have found little substantial traction, and politicians and the general public are instead engaged in a debate about the causes and effects of climate change that bears little resemblance to the state of scientific knowledge. Uncertainty plays a pivotal role in that public debate, and arguments against mitigation are frequently couched in terms of uncertainty. We show that the rhetorical uses of scientific uncertainty in public debate by some actors (often with vested interests or political agendas) contrast with the mathematical result that greater uncertainty about the extent of warming is virtually always associated with an increased risk: The expected damage costs increase as a function of uncertainty about future warming. We suggest ways in which the actual implications of scientific uncertainty can be better communicated and how scientific uncertainty should be understood as an impetus, rather than a barrier, for climate mitigation.

Naval Medical Research and Development News. Volume 7, Issue 3, March 2015

DTIC Science & Technology

2016-02-29

coordinated with the WHO on a combined animal/human health consultation mission to Egypt, including experts from the World Organization of Animal Health ...actively in emerging global health challenges like this. As we do so, we offer distinct diplomatic value as an expression of U.S. humanitarian and...scientific leadership, while also advancing health security and scientific progress. The biannual Navy Medical Research and Development Enterprise

The Media as an Invaluable Tool for Informal Earth System Science Education

NASA Astrophysics Data System (ADS)

James, E.; Gautier, C.

2001-12-01

One of the most widely utilized avenues for educating the general public about the Earth's environment is the media, be it print, radio or broadcast. Accurate and effective communication of issues in Earth System Science (ESS), however, is significantly hindered by the public's relative scientific illiteracy. Discussion of ESS concepts requires the laying down of a foundation of complex scientific information, which must first be conveyed to an incognizant audience before any strata of sophisticated social context can be appropriately considered. Despite such a substantial obstacle to be negotiated, the environmental journalist is afforded the unique opportunity of providing a broad-reaching informal scientific education to a largely scientifically uninformed population base. This paper will review the tools used by various environmental journalists to address ESS issues and consider how successful each of these approaches has been at conveying complex scientific messages to a general audience lacking sufficient scientific sophistication. Different kinds of media materials used to this effect will be analyzed for their ideas and concepts conveyed, as well as their effectiveness in reaching the public at large.

The Lenfest Ocean Program's experience in building institutional support for connecting science and decision-making in marine systems

NASA Astrophysics Data System (ADS)

Bednarek, A.; Close, S.; Curran, K.; Hudson, C.

2017-12-01

Addressing contemporary sustainability challenges requires attention to the integration of scientific knowledge into decision-making and deliberation. However, this remains a challenge in practice. We contend that careful stewardship of this process of integration can result in positive, durable outcomes by reconciling the production and use of scientific knowledge, and improve its relevance and utility to decision-makers. We will share lessons learned from a grantmaking program that has addressed this challenge through programmatic innovations, including by supporting staff devoted to an intermediary role. Over the past 13 years, the Lenfest Ocean Program served in a boundary spanning role by integrating decision-makers into the scoping and outreach of program supported scientific research grants. Program staff engage with decision-makers and influencers to identify policy-relevant research questions and approaches, ensuring that the research direction addresses users' needs. As research progresses, the staff monitor the grant's progress to improve the match between the research and user needs. The process is resource-intensive, however, and raises interesting questions about the role and development of this kind of specialist within different kinds of institutions, including funding agencies. We suggest that nurturing this role as a practice and profession could ultimately help the scientific community more efficiently respond to sustainability challenges.

Galen Wagner, M.D., Ph.D. (1939-2016) as international mentor of young investigators in electrocardiology.

PubMed

Swenne, Cees A; Pahlm, Olle; Atwater, Brett D; Bacharova, Ljuba

This paper describes a substantial part of the international mentoring network of students and young investigators in electrocardiology that developed around Dr. Galen Wagner (1939-2016), including many experiences of his mentees and co-mentors. The paper is meant to stimulate thinking about international mentoring as a means to achieve important learning experiences and personal development of young investigators, to intensify international scientific cooperation, and to stimulate scientific production. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

HOW TO WRITE A SCIENTIFIC ARTICLE

PubMed Central

Manske, Robert C.

2012-01-01

Successful production of a written product for submission to a peer‐reviewed scientific journal requires substantial effort. Such an effort can be maximized by following a few simple suggestions when composing/creating the product for submission. By following some suggested guidelines and avoiding common errors, the process can be streamlined and success realized for even beginning/novice authors as they negotiate the publication process. The purpose of this invited commentary is to offer practical suggestions for achieving success when writing and submitting manuscripts to The International Journal of Sports Physical Therapy and other professional journals. PMID:23091783

GMOs in Russia: Research, Society and Legislation

PubMed Central

Korobko, I. V.; Georgiev, P. G.; Skryabin, K. G.; Kirpichnikov, M. P.

2016-01-01

Russian legislation lags behind the rapid developments witnessed in genetic engineering. Only a scientifically based and well-substantiated policy on the place of organisms that are created with the use of genetic engineering technologies and an assessment of the risks associated with them could guarantee that the breakthroughs achieved in modern genetic engineering technologies are effectively put to use in the real economy. A lack of demand for such breakthroughs in the practical field will lead to stagnation in scientific research and to a loss of expertise. PMID:28050262

Seeing the Solar System through Two Perspectives. Part 1 of a Series Focusing on Learning Progressions

ERIC Educational Resources Information Center

Thornburgh, Bill R.; Tretter, Tom R.; Duckwall, Mark

2015-01-01

Space has fascinated and intrigued humans of all ages since time immemorial, and continues to do so today. The natural curiosity is engaged when looking up into the sky, notice patterns among celestial objects such as the Sun, Moon, and stars, and wonder. Scientific understanding of those patterns has progressed immensely over the span of human…

Scientific Revolutions to the nth power: n = 0, 1, 2, 3.

NASA Astrophysics Data System (ADS)

Beichler, James

2008-04-01

Thomas Kuhn's description and characterization of scientific revolutions set the standard for interpreting and understanding these events, but his characterization introduced an anomaly. Newtonian science was at the pinnacle of its success immediately prior to the Second Scientific Revolution. From an evolutionary point-of-view, there were no crises to be solved just problems within the Newtonian paradigm, whereas the specific crises that initiated the revolution are evident from everyone's point-of-view after the revolution. This paradox is well recognized, but it seems not to be a problem and is just ignored as if it were not important or significant. Yet this discrepancy strikes at the very heart of physics and the overall progress of science. Historical conditions currently parallel the period immediately prior to the Second Scientific Revolution indicating that a new scientific revolution is approaching. When a comparison of the two periods is made, new characteristics of scientific revolutions are identified, the paradox is solved and evidence of a Zeroth Scientific Revolution emerges from the historical record.

THE MODERN SCIENTIFIC RESEARCH ON THE THEORY OF TRADITIONAL CHINESE MEDICINE

PubMed Central

Wei-Bo, Lu

1983-01-01

Traditional Chinese Medicine, unlike in many countries, with its well defined concepts and content, is developed due to the progressive policies of the government. The past 30 years work on scientific lines complemented by the successful and significant efforts to integrate Traditional Chinese Medicine with Western medicine has proved the scientific essence of the theory of this system. Added to this are the social acceptebility, relevance, and effectiveness. This brief review of some of the major work done indicates the bright future it has in contributing to the improvement of the health of the world. PMID:22556966

Der Begriff der Verständlichkeit in der modernen Physik (1948).

PubMed

Feyerabend, Paul K

2016-06-01

This is a critical transcription of Paul Feyerabend's earliest extant essay "Der Begriff der Verständlichkeit in der modernen Physik" (1948) recovered from the European Forum Alpbach archives. In it, Feyerabend defends positivism as a progressive framework for scientific research in certain stages of scientific development. He argues that in physics visualizability (Anschaulichkeit) and intelligibility (Verständlichkeit) are time-conditioned concepts: what is deemed visualizable in the development of physical theories is relative to a specific historical context and changes over time. He concludes that from time to time the abandonment of visualizability is crucial for progress in physics, as it is conducive to major theory change, illustrating the point on the basis of advances in atomic theory. Copyright © 2015 Elsevier Ltd. All rights reserved.

Theories on migration processes of Cd in Jiaozhou Bay

NASA Astrophysics Data System (ADS)

Yang, Dongfang; Li, Haixia; Wang, Qi; Ding, Jun; Zhang, Longlei

2018-03-01

Understanding the migration progress is essential to pollution control, while developing theories for the migration progress is the scientific basis. This paper further developed five key theories on migration processes of Cd including homogeneous theory, environmental dynamic theory, horizontal loss theory, migration trend theory and vertical migration theory, respectively. The performance and practical values of these theories were demonstrated in the application of these on analyzing the migration process of Cd in Jiaozhou Bay. Results these theory helpful to better understand the migration progress of pollutants in marine bay.

Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease.

PubMed

Rorabaugh, Jacki M; Chalermpalanupap, Termpanit; Botz-Zapp, Christian A; Fu, Vanessa M; Lembeck, Natalie A; Cohen, Robert M; Weinshenker, David

2017-11-01

See Grinberg and Heinsen (doi:10.1093/brain/awx261) for a scientific commentary on this article. Clinical evidence suggests that aberrant tau accumulation in the locus coeruleus and noradrenergic dysfunction may be a critical early step in Alzheimer’s disease progression. Yet, an accurate preclinical model of these phenotypes that includes early pretangle tau accrual in the locus coeruleus, loss of locus coeruleus innervation and deficits locus coeruleus/norepinephrine modulated behaviours, does not exist, hampering the identification of underlying mechanisms and the development of locus coeruleus-based therapies. Here, a transgenic rat (TgF344-AD) expressing disease-causing mutant amyloid precursor protein (APPsw) and presenilin-1 (PS1ΔE9) was characterized for histological and behavioural signs of locus coeruleus dysfunction reminiscent of mild cognitive impairment/early Alzheimer’s disease. In TgF344-AD rats, hyperphosphorylated tau was detected in the locus coeruleus prior to accrual in the medial entorhinal cortex or hippocampus, and tau pathology in the locus coeruleus was negatively correlated with noradrenergic innervation in the medial entorhinal cortex. Likewise, TgF344-AD rats displayed progressive loss of hippocampal norepinephrine levels and locus coeruleus fibres in the medial entorhinal cortex and dentate gyrus, with no frank noradrenergic cell body loss. Cultured mouse locus coeruleus neurons expressing hyperphosphorylation-prone mutant human tau had shorter neurites than control neurons, but similar cell viability, suggesting a causal link between pretangle tau accrual and altered locus coeruleus fibre morphology. TgF344-AD rats had impaired reversal learning in the Morris water maze compared to their wild-type littermates, which was rescued by chemogenetic locus coeruleus activation via designer receptors exclusively activated by designer drugs (DREADDs). Our results indicate that TgF344-AD rats uniquely meet several key criteria for a suitable model of locus coeruleus pathology and dysfunction early in Alzheimer’s disease progression, and suggest that a substantial window of opportunity for locus coeruleus/ norepinephrine-based therapeutics exists.

RESPIRATORY EPIDEMIOLOGY OF HOUSEHOLD AIR POLLUTION EXPOSURES IN DEVELOPING COUNTRIES

EPA Science Inventory

Acute and chronic respiratory diseases impose a huge public health burden in the developing world. A large and growing body of scientific evidence indicates that household air pollution exposures contribute substantially to this burden. The most important source of indoor air p...

Students' Environmental Competence Formation as a Pedagogical Problem

ERIC Educational Resources Information Center

Ponomarenko, Yelena V.; Yessaliev, Aidarbek A.; Kenzhebekova, Rabiga I.; Moldabek, Kulahmet; Larchekova, Liudmila A.; Dairbekov, Serik S.; Asambaeva, Lazzat

2016-01-01

Environmentally conscious and preparation of competent professionals' in higher education system in Kazakhstan is a priority. The need for more effective environmental competence formation for students actualizes the problem of development and scientific substantiation of the theoretical model of students' environmental competence, methods of…

"Deliberate Preparation" as an Evidence-Based Focus for Primary Physical Education

ERIC Educational Resources Information Center

Giblin, Susan; Collins, David; MacNamara, Aine; Kiely, John

2014-01-01

There is substantial scientific research suggesting the physical and psychological health benefits of a physically active lifestyle. Consequently, governments worldwide prioritize policies, finances, and resources in healthcare, education, and sports sectors to increase mass participation in physical activity. However, practices in physical…

49 CFR 190.331 - Petitions for rulemaking.

Code of Federal Regulations, 2013 CFR

2013-10-01

... government; (3) The regulatory burden on small businesses, small organizations and small governmental... relevant technical, scientific or other data as available to the petitioner, and any specific known cases... substantial, and information and data related to that impact are available to the petitioner, the Associate...

The public's trust in scientific claims regarding offshore oil drilling.

PubMed

Carlisle, Juliet E; Feezell, Jessica T; Michaud, Kristy E H; Smith, Eric R A N; Smith, Leeanna

2010-09-01

Our study examines how individuals decide which scientific claims and experts to believe when faced with competing claims regarding a policy issue. Using an experiment in a public opinion survey, we test the source content and credibility hypotheses to assess how much confidence people have in reports about scientific studies of the safety of offshore oil drilling along the California coast. The results show that message content has a substantial impact. People tend to accept reports of scientific studies that support their values and prior beliefs, but not studies that contradict them. Previous studies have shown that core values influence message acceptance. We find that core values and prior beliefs have independent effects on message acceptance. We also find that the sources of the claims make little difference. Finally, the public leans toward believing reports that oil drilling is riskier than previously believed.

The dual frontier: Patented inventions and prior scientific advance.

PubMed

Ahmadpoor, Mohammad; Jones, Benjamin F

2017-08-11

The extent to which scientific advances support marketplace inventions is largely unknown. We study 4.8 million U.S. patents and 32 million research articles to determine the minimum citation distance between patented inventions and prior scientific advances. We find that most cited research articles (80%) link forward to a future patent. Similarly, most patents (61%) link backward to a prior research article. Linked papers and patents typically stand 2 to 4 degrees distant from the other domain. Yet, advances directly along the patent-paper boundary are notably more impactful within their own domains. The distance metric further provides a typology of the fields, institutions, and individuals involved in science-to-technology linkages. Overall, the findings are consistent with theories that emphasize substantial and fruitful connections between patenting and prior scientific inquiry. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning.

PubMed

Hanauer, David I; Graham, Mark J; Betancur, Laura; Bobrownicki, Aiyana; Cresawn, Steven G; Garlena, Rebecca A; Jacobs-Sera, Deborah; Kaufmann, Nancy; Pope, Welkin H; Russell, Daniel A; Jacobs, William R; Sivanathan, Viknesh; Asai, David J; Hatfull, Graham F

2017-12-19

Engaging undergraduate students in scientific research promises substantial benefits, but it is not accessible to all students and is rarely implemented early in college education, when it will have the greatest impact. An inclusive Research Education Community (iREC) provides a centralized scientific and administrative infrastructure enabling engagement of large numbers of students at different types of institutions. The Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) is an iREC that promotes engagement and continued involvement in science among beginning undergraduate students. The SEA-PHAGES students show strong gains correlated with persistence relative to those in traditional laboratory courses regardless of academic, ethnic, gender, and socioeconomic profiles. This persistent involvement in science is reflected in key measures, including project ownership, scientific community values, science identity, and scientific networking. Copyright © 2017 the Author(s). Published by PNAS.

Concept of scientific wildlife conservation and its dissemination

PubMed Central

ZHOU, Xue-Hong; WAN, Xiao-Tong; JIN, Yu-Hui; ZHANG, Wei

2016-01-01

In recent years, wildlife conservation has attracted great public attention. However, substantial distinctions can be found in the prevailing concepts of wildlife conservation, particularly with the recent notion that emphasizes animal rights. Wildlife welfare and wildlife rights are not synonymous, with welfare more compatible with the reasonable and legal utilization of wildlife. The key to scientific wildlife conservation is the appropriate awareness and appreciation of the relationship between wildlife conservation and utilization and the theoretical basis of holism. Nevertheless, rational biases regarding the public’s understanding of wildlife conservation and the spread of information via social media still exist. As such, expansion of the concept of scientific wildlife conservation requires the application of several measures. Wildlife conservation researchers should be regarded as the most important disseminators of scientifically-based information, with education in schools and universities of growing importance. Furthermore, the media should shoulder the social responsibility for the accurate dissemination of conservation information. PMID:27686785

Concept of scientific wildlife conservation and its dissemination.

PubMed

Zhou, Xue-Hong; Wan, Xiao-Tong; Jin, Yu-Hui; Zhang, Wei

2016-09-18

In recent years, wildlife conservation has attracted great public attention. However, substantial distinctions can be found in the prevailing concepts of wildlife conservation, particularly with the recent notion that emphasizes animal rights. Wildlife welfare and wildlife rights are not synonymous, with welfare more compatible with the reasonable and legal utilization of wildlife. The key to scientific wildlife conservation is the appropriate awareness and appreciation of the relationship between wildlife conservation and utilization and the theoretical basis of holism. Nevertheless, rational biases regarding the public's understanding of wildlife conservation and the spread of information via social media still exist. As such, expansion of the concept of scientific wildlife conservation requires the application of several measures. Wildlife conservation researchers should be regarded as the most important disseminators of scientifically-based information, with education in schools and universities of growing importance. Furthermore, the media should shoulder the social responsibility for the accurate dissemination of conservation information.

An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning

PubMed Central

Hanauer, David I.; Graham, Mark J.; Betancur, Laura; Bobrownicki, Aiyana; Cresawn, Steven G.; Garlena, Rebecca A.; Jacobs-Sera, Deborah; Kaufmann, Nancy; Pope, Welkin H.; Russell, Daniel A.; Jacobs, William R.; Sivanathan, Viknesh; Asai, David J.

2017-01-01

Engaging undergraduate students in scientific research promises substantial benefits, but it is not accessible to all students and is rarely implemented early in college education, when it will have the greatest impact. An inclusive Research Education Community (iREC) provides a centralized scientific and administrative infrastructure enabling engagement of large numbers of students at different types of institutions. The Science Education Alliance–Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) is an iREC that promotes engagement and continued involvement in science among beginning undergraduate students. The SEA-PHAGES students show strong gains correlated with persistence relative to those in traditional laboratory courses regardless of academic, ethnic, gender, and socioeconomic profiles. This persistent involvement in science is reflected in key measures, including project ownership, scientific community values, science identity, and scientific networking. PMID:29208718

Scientific Integrity and Professional Ethics at AGU - Strategies and Actions to Impact Sexual Harassment in Science and other Work Climate Issues

NASA Astrophysics Data System (ADS)

McPhaden, Michael; Davidson, Eric; McEntee, Christine; Williams, Billy

2017-04-01

The American Geophysical Union (AGU), a scientific society of 62,000 members worldwide, has established a set of scientific integrity and professional ethics guidelines for the actions of its members, for the governance of the union in its internal activities, and for the operations and participation in its publications and scientific meetings. More recently AGU has undertaken strategies and actions to help address the issue of harassment in the sciences and other work climate issues. This presentation will provide an overview of the role of scientific societies in helping to address these important issues, as well as specific strategies and actions underway at AGU and other societies. Progress to date and remaining challenges of this effort will be discussed, including AGU's work to provide additional program strength in this area.

Integrative Convergence in Neuroscience: Trajectories, Problems, and the Need for a Progressive Neurobioethics

NASA Astrophysics Data System (ADS)

Giordano, J.

The advanced integrative scientific convergence (AISC) model represents a viable approach to neuroscience. Beyond simple multi-disciplinarity, the AISC model unifies constituent scientific and technological fields to foster innovation, invention and new ways of addressing seemingly intractable questions. In this way, AISC can yield novel methods and foster new trajectories of knowledge and discovery, and yield new epistemologies. As stand-alone disciplines, each and all of the constituent fields generate practical and ethical issues, and their convergence may establish a unique set of both potential benefits and problems. To effectively attend to these contingencies requires pragmatic assessment of the actual capabilities and limits of neurofocal AISC, and an openness to what new knowledge and scientific/technological achievements may be produced, and how such outcomes can affect humanity, the human condition, society and the global environment. It is proposed that a progressive neurobioethics may be needed to establish both a meta-ethical framework upon which to structure ethical decisions, and a system and method of ethics that is inclusive, convergent and innovative, and in thus aligned with and meaningful to use of an AISC model in neuroscience.

Science to the rescue or contingent progress? Comparing 10 years of public, expert and policy discourses on new and emerging science and technology in the United Kingdom.

PubMed

Smallman, Melanie

2017-05-01

Over the past 10 years, numerous public debates on new and emerging science and technologies have taken place in the United Kingdom. In this article, we characterise the discourses emerging from these debates and compare them to the discourses in analogous expert scientific and policy reports. We find that while the public is broadly supportive of new scientific developments, they see the risks and social and ethical issues associated with them as unpredictable but inherent parts of the developments. In contrast, the scientific experts and policymakers see risks and social and ethical issues as manageable and quantifiable with more research and knowledge. We argue that these differences amount to two different sociotechnical imaginaries or views of science and how it shapes our world - an elite imaginary of 'science to the rescue' shared by scientists and policymakers and public counter-imaginary of 'contingent progress'. We argue that these two imaginaries indicate that, but also help explain why, public dialogue has had limited impact on public policy.

Falling Short of the Rights to Health and Scientific Progress

PubMed Central

Henry, Ian; Lessem, Erica

2016-01-01

Abstract The incorporation of human rights-based approaches into TB programs is gaining traction, but little work has explored the application of human rights norms and principles to TB research (a domain traditionally left to bioethics). TB research is gravely underfunded, and the scarcity of resources for TB drug development has contributed to the stubborn persistence of the TB epidemic and helped to create the conditions under which drug-resistant TB has developed and spread. This article shows how human rights—particularly human rights standards, norms, and principles related to the rights to health and benefits of scientific progress—can provide insight into understanding how underfunding TB drug research undermines efforts to secure access to safe, effective, and optimized treatment for all people with TB. By analyzing TB research in relation to the rights to health and scientific progress, we aim to clarify the legal obligations of governments to improve the TB drug research system, fund TB research, and make medical advances that result from research available to all people with TB. PMID:27780996

Uremic Solutes in Chronic Kidney Disease and Their Role in Progression.

PubMed

van den Brand, Jan A J G; Mutsaers, Henricus A M; van Zuilen, Arjan D; Blankestijn, Peter J; van den Broek, Petra H; Russel, Frans G M; Masereeuw, Rosalinde; Wetzels, Jack F M

2016-01-01

To date, over 150 possible uremic solutes have been listed, but their role in the progression of CKD is largely unknown. Here, the association between a selected panel of uremic solutes and progression in CKD patients was investigated. Patients from the MASTERPLAN study, a randomized controlled trial in CKD patients with a creatinine clearance between 20 and 70 ml/min per 1.73m2, were selected based on their rate of eGFR decline during the first five years of follow-up. They were categorized as rapid (decline >5 ml/min per year) or slow progressors. Concentrations of eleven uremic solutes were obtained at baseline and after one year of follow-up. Logistic regression was used to compare the odds for rapid to slow progression by uremic solute concentrations at baseline. Variability in uremic solute levels was assessed using scatter plots, and limits of variability were calculated. In total, 40 rapidly and 40 slowly progressing patients were included. Uremic solutes were elevated in all patients compared to reference values for healthy persons. The serum levels of uremic solutes were not associated with rapid progression. Moreover, we observed substantial variability in solute levels over time. Elevated concentrations of uremic solutes measured in this study did not explain differences in rate of eGFR decline in CKD patients, possibly due to lack of power as a result of the small sample size, substantial between patient variability, and variability in solute concentrations over time. The etiology of intra-individual variation in uremic solute levels remains to be elucidated.

Dr. Goddard and a 1918 version of 'Bazooka'

NASA Technical Reports Server (NTRS)

2004-01-01

Dr. Robert H. Goddard loading a 1918 version of the Bazooka of World War II. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

Consistency of nature of science views across scientific and socio-scientific contexts

NASA Astrophysics Data System (ADS)

Khishfe, Rola

2017-03-01

The purpose of the investigation was to investigate the consistency of NOS views among high school students across different scientific and socio-scientific contexts. A total of 261 high school students from eight different schools in Lebanon participated in the investigation. The schools were selected based on different geographical areas in Lebanon and the principals' consent to participate in the study. The investigation used a qualitative design to compare the responses of students across different contexts/topics. All the participants completed a five-item open-ended questionnaire, which includes five topics addressing scientific and socio-scientific contexts. The items of the questionnaire addressed the empirical, tentative, and subjective aspects of NOS. Quantitative and qualitative analyses were conducted to answer the research questions. Results showed that participants' views of the emphasised NOS aspects were mostly inconsistent. Plus, there was variance in participants' views of NOS between scientific and socio-scientific issues. Discussion of the results related to differential developmental progression, contextual factors, social constructivist perspective, different domains of knowledge, and students' individual differences.

Science and religion in dialogue over the global commons

NASA Astrophysics Data System (ADS)

Edenhofer, Ottmar; Flachsland, Christian; Knopf, Brigitte

2015-10-01

The Pope's encyclical makes unprecedented progress in developing scientific dialogue with religion by drawing on research, and encouraging further discussion about the ethical challenge of governing the global commons.

42 CFR 93.310 - Institutional investigation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... encompass scientific instruments shared by a number of users, custody may be limited to copies of the data or evidence on such instruments, so long as those copies are substantially equivalent to the evidentiary value of the instruments. Whenever possible, the institution must take custody of the records— (1...

42 CFR 93.310 - Institutional investigation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... encompass scientific instruments shared by a number of users, custody may be limited to copies of the data or evidence on such instruments, so long as those copies are substantially equivalent to the evidentiary value of the instruments. Whenever possible, the institution must take custody of the records— (1...

42 CFR 93.310 - Institutional investigation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... encompass scientific instruments shared by a number of users, custody may be limited to copies of the data or evidence on such instruments, so long as those copies are substantially equivalent to the evidentiary value of the instruments. Whenever possible, the institution must take custody of the records— (1...

42 CFR 93.310 - Institutional investigation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... encompass scientific instruments shared by a number of users, custody may be limited to copies of the data or evidence on such instruments, so long as those copies are substantially equivalent to the evidentiary value of the instruments. Whenever possible, the institution must take custody of the records— (1...

LCIA framework and cross-cutting issues guidance within the UNEP/SETAC Life Cycle Initiative

EPA Science Inventory

Increasing needs for decision support and advances in scientific knowledge within life cycle assessment (LCA) led to substantial efforts to provide global guidance on environmental life cycle impact assessment (LCIA) indicators under the auspices of the UNEP-SETAC Life Cycle Init...

FOCUSING ON CHILDREN’S INHALATION DOSIMETRY AND HEALTH EFFECTS FOR RISK ASSESSMENT: AN INTRODUCTION

EPA Science Inventory

Substantial effort has been invested in improving children’s health risk assessment in recent years. However, the body of scientific evidence in support of children’s health assessment is constantly advancing requiring continual updating of risk assessment methods. Children’s i...

EPA (ENVIRONMENTAL PROTECTION AGNCY) FIELD GUIDE FOR SCIENTIFIC SUPPORT ACTIVITIES ASSOCIATED WITH SUPERFUND EMERGENCY RESPONSE

EPA Science Inventory

The Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA) grants the President the authority to respond to releases of hazardous chemical substances that imminently and substantially threaten public health or welfare, or the environment. The Act, w...

[Evaluation and prioritisation of the scientific research in Spain. Researchers' point of view].

PubMed

María Martín-Moreno, José; Juan Toharia, José; Gutiérrez Fuentes, José Antonio

2008-12-01

The assessment and prioritisation of research activity are essential components of any Science, Technology and Industry System. Data on researchers' perspectives in this respect are scarce. The objective of this paper was to describe Spanish scientists' point of view on the current evaluation system in Spain and how they believe this system should be functionally structured. From the sampling frame formed by established Spanish scientists, listed in the databases of CSIC and FIS (Institute of Health Carlos III), clinical, biomedical-non clinical, and physics and chemical researchers were randomly selected. Two hundred and eleven interviews were carried out by means of a computer-assisted telephone interviewing system. Researchers expressed their acknowledgement of progress in the Spanish research field but made their wish clear to progress towards better scientific scenarios. In their assessment, they gave a score of 5.4 to scientific policy, as opposed to 9.4 when speaking about the goals, reflecting the desire for a better policy definition, with clear objectives, stable strategies and better coordination of R&D activities (the current coordination received a score of 3.9, while the desirable coordination was valued as high as 9.2). There was certain agreement regarding the need for a prioritisation criteria which preserves some degree of creativity by researchers. They also stated that they would like to see an independent research structure with social prestige and influence. The interviewed researchers believe that the evaluation of scientific activities is fundamental in formulating a sound scientific policy. Prioritisation should arise from appropriate evaluation. Strategies properly coordinated among all the stakeholders (including the private sector) should be fostered. Budget sufficiency, stability, and better organization of independent researchers should be the backbone of any strategy tailored to increase their capacity to influence future scientific policies.

Not Just a "Fleck" on the Epistemic Landscape: A Reappraisal of Ludwik Fleck's Views of the Nature of Scientific Progress and Change in Relation to Contemporary Educational and Social Issues

ERIC Educational Resources Information Center

Carifio, James; Perla, Rocco J.

2013-01-01

In contrast to Thomas Kuhn, the work of Ludwik Fleck, a Polish-born physician, microbiologist, and epistemologist, is conspicuously absent from the science education literature. His originally obscure monograph first published in German in 1935, "Genesis and Development of a Scientific Fact," anticipates a number of views explicated by…

A Survey of the Collaboration Rate of Authors in the E-Learning Subject Area over a 10-Year Period (2005-2014) Using Web of Science

ERIC Educational Resources Information Center

Mohammadi, Aeen; Asadzandi, Shadi; Malgard, Shiva

2017-01-01

Partnership is one of the mechanisms of scientific development, and scientific collaboration or co-authorship is considered a key element in the progress of science. This study is a survey with a scientometric approach focusing on the field of e-learning products over 10 years. In an Advanced Search of the Web of Science, the following search…

Bacterial Chemotaxis: The Early Years of Molecular Studies

PubMed Central

Hazelbauer, Gerald L.

2014-01-01

This review focuses on the early years of molecular studies of bacterial chemotaxis and motility, beginning in the 1960s with Julius Adler's pioneering work. It describes key observations that established the field and made bacterial chemotaxis a paradigm for the molecular understanding of biological signaling. Consideration of those early years includes aspects of science seldom described in journals: the accidental findings, personal interactions, and scientific culture that often drive scientific progress. PMID:22994495

JPRS Report, Soviet Union. World Economy & International Relations, No. 12, December 1988.

DTIC Science & Technology

1989-04-18

conditions of scientific and technological progress is considered to be the main factor influencing such process. Leading companies are trying to...departments, groups etc. Project teams are widely used when a new kind of product is developed or when R and D or technological problems are to be...medium-sized partners are integrated into a single scientific and technological entity by big companies. Cooperation in production is also important

Inseparability of science history and discovery

NASA Astrophysics Data System (ADS)

Herndon, J. M.

2010-04-01

Science is very much a logical progression through time. Progressing along a logical path of discovery is rather like following a path through the wilderness. Occasionally the path splits, presenting a choice; the correct logical interpretation leads to further progress, the wrong choice leads to confusion. By considering deeply the relevant science history, one might begin to recognize past faltering in the logical progression of observations and ideas and, perhaps then, to discover new, more precise understanding. The following specific examples of science faltering are described from a historical perspective: (1) Composition of the Earth's inner core; (2) Giant planet internal energy production; (3) Physical impossibility of Earth-core convection and Earth-mantle convection, and; (4) Thermonuclear ignition of stars. For each example, a revised logical progression is described, leading, respectively, to: (1) Understanding the endo-Earth's composition; (2) The concept of nuclear georeactor origin of geo- and planetary magnetic fields; (3) The invalidation and replacement of plate tectonics; and, (4) Understanding the basis for the observed distribution of luminous stars in galaxies. These revised logical progressions clearly show the inseparability of science history and discovery. A different and more fundamental approach to making scientific discoveries than the frequently discussed variants of the scientific method is this: An individual ponders and through tedious efforts arranges seemingly unrelated observations into a logical sequence in the mind so that causal relationships become evident and new understanding emerges, showing the path for new observations, for new experiments, for new theoretical considerations, and for new discoveries. Science history is rich in "seemingly unrelated observations" just waiting to be logically and causally related to reveal new discoveries.

Recent progress and future plans on the search for extraterrestrial intelligence.

PubMed

Papagiannis, M D

1985-11-14

The possibility of life in other parts of the Universe has long occupied the human mind, but actual searches only began in 1960 with Project OZMA conducted by Frank Drake. In the past 25 years, we have made impressive progress, and this new field has gained broad scientific recognition including the support of the US and the Soviet National Academies, and the endorsement of the International Astronomical Union.

Real-time fMRI neurofeedback: Progress and challenges

PubMed Central

Sulzer, J.; Haller, S.; Scharnowski, F.; Weiskopf, N.; Birbaumer, N.; Blefari, M.L.; Bruehl, A.B.; Cohen, L.G.; deCharms, R.C.; Gassert, R.; Goebel, R.; Herwig, U.; LaConte, S.; Linden, D.; Luft, A.; Seifritz, E.; Sitaram, R.

2016-01-01

In February of 2012, the first international conference on real time functional magnetic resonance imaging (rtfMRI) neurofeedback was held at the Swiss Federal Institute of Technology Zurich (ETHZ), Switzerland. This review summarizes progress in the field, introduces current debates, elucidates open questions, and offers viewpoints derived from the conference. The review offers perspectives on study design, scientific and clinical applications, rtfMRI learning mechanisms and future outlook. PMID:23541800

FUSION ENERGY SCIENCES WORKSHOP ON PLASMA MATERIALS INTERACTIONS: Report on Science Challenges and Research Opportunities in Plasma Materials Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maingi, Rajesh; Zinkle, Steven J.; Foster, Mark S.

2015-05-01

The realization of controlled thermonuclear fusion as an energy source would transform society, providing a nearly limitless energy source with renewable fuel. Under the auspices of the U.S. Department of Energy, the Fusion Energy Sciences (FES) program management recently launched a series of technical workshops to “seek community engagement and input for future program planning activities” in the targeted areas of (1) Integrated Simulation for Magnetic Fusion Energy Sciences, (2) Control of Transients, (3) Plasma Science Frontiers, and (4) Plasma-Materials Interactions aka Plasma-Materials Interface (PMI). Over the past decade, a number of strategic planning activities1-6 have highlighted PMI and plasmamore » facing components as a major knowledge gap, which should be a priority for fusion research towards ITER and future demonstration fusion energy systems. There is a strong international consensus that new PMI solutions are required in order for fusion to advance beyond ITER. The goal of the 2015 PMI community workshop was to review recent innovations and improvements in understanding the challenging PMI issues, identify high-priority scientific challenges in PMI, and to discuss potential options to address those challenges. The community response to the PMI research assessment was enthusiastic, with over 80 participants involved in the open workshop held at Princeton Plasma Physics Laboratory on May 4-7, 2015. The workshop provided a useful forum for the scientific community to review progress in scientific understanding achieved during the past decade, and to openly discuss high-priority unresolved research questions. One of the key outcomes of the workshop was a focused set of community-initiated Priority Research Directions (PRDs) for PMI. Five PRDs were identified, labeled A-E, which represent community consensus on the most urgent near-term PMI scientific issues. For each PRD, an assessment was made of the scientific challenges, as well as a set of actions to address those challenges. No prioritization was attempted amongst these five PRDs. We note that ITER, an international collaborative project to substantially extend fusion science and technology, is implicitly a driver and beneficiary of the research described in these PRDs; specific ITER issues are discussed in the background and PRD chapters. For succinctness, we describe these PRDs directly below; a brief introduction to magnetic fusion and the workshop process/timeline is given in Chapter I, and panelists are listed in the Appendix.« less

The Mathematical Education of Engineers.

ERIC Educational Resources Information Center

Gnedenko, B. V.; Khalil, Z.

1979-01-01

Several general aspects are discussed. These include the role of mathematics in scientific and technical progress, some deficiencies in training, the role of mathematics in engineering faculties, and methods of improving mathematical training. (MP)

Progress at ROEN - Fortaleza Geodetic Station

NASA Astrophysics Data System (ADS)

Kaufman, Pierre; Macilio Pereira de Lucena, A.; Tateyama, Claudio E.

1999-08-01

This report presents the works developed at ROEN: Radio-Observatorio Espacial do Nordeste, Eusebio near Fortaleza, CE, Brazil, in 1998. Activities were related to observing sessions, major maintenance items, and scientific results obtained.

42 CFR 4.3 - Purpose of the Library.

Code of Federal Regulations, 2012 CFR

2012-10-01

... medical and related sciences and aid the dissemination and exchange of scientific and other information important to the progress of medicine and the public health. The Library acquires and maintains library...

42 CFR 4.3 - Purpose of the Library.

Code of Federal Regulations, 2014 CFR

2014-10-01

... medical and related sciences and aid the dissemination and exchange of scientific and other information important to the progress of medicine and the public health. The Library acquires and maintains library...

42 CFR 4.3 - Purpose of the Library.

Code of Federal Regulations, 2011 CFR

2011-10-01

... medical and related sciences and aid the dissemination and exchange of scientific and other information important to the progress of medicine and the public health. The Library acquires and maintains library...

42 CFR 4.3 - Purpose of the Library.

Code of Federal Regulations, 2013 CFR

2013-10-01

... medical and related sciences and aid the dissemination and exchange of scientific and other information important to the progress of medicine and the public health. The Library acquires and maintains library...

The benefit of angiotensin AT1 receptor blockers for early treatment of hypertensive patients.

PubMed

Trimarco, Bruno; Santoro, Ciro; Pepe, Marco; Galderisi, Maurizio

2017-12-01

ESC guidelines for management of arterial hypertension allow one to choose among five classes of antihypertensive drugs indiscriminately. They are based on the principle that in the management of hypertensive patients, it is fundamental to reduce blood pressure (BP), independently of the utilized drug. However, it has been demonstrated that the renin-angiotensin system (RAS) plays a relevant role in the hypertensive-derived development and progression of organ damage. Thus, antihypertensive drugs interfering with the RAS should be preferred in preventing and reducing target organ damage. The availability of two classes of drugs, ACE-inhibitors and angiotensin AT1 receptor blockers (ARBs), both interfering with the RAS, makes the choice between them difficult. Both pharmacological strategies offer an effective BP control, and a substantial improvement of prognosis in different associated pathologies. Regarding cardiovascular prevention, ACE-inhibitors have an extensive scientific literature regarding utility in high-risk patients. Nevertheless, there is evidence to support the concept that in the early phases of organ tissue damage, the RAS is activated, but the ACE pathway producing angiotensin II is not always employed. Accordingly, ACE-inhibitors appear to be less effective, whereas ARBs have a greater beneficial action in the initial stages of atherosclerotic disease. Moreover, patients undergoing ARBs therapy show a substantially lower risk of therapy discontinuation when compared to those treated with ACE-inhibitors, because of a better tolerability. In conclusion, ACE-inhibitors should be used in patients who have already developed organ damage, but tolerate this drug well, while ARBs should be the first choice in naïve hypertensive patients without organ damage or at the initial stages of disease.

Disasters, Scientists and Society: The Quest for Wisdom (Sergey Soloviev Medal Lecture)

NASA Astrophysics Data System (ADS)

Okal, Emile A.

2013-04-01

The horror which accompanied the significant natural disasters of the past decade (major earthquakes, tsunamis, hurricanes...), many of which exposing inadequate preparation and/or response, has revived our quest for improved mitigation, or in simple words, enhanced wisdom, to confront natural hazards, both in scientific and societal terms. The Sumatra and Tohoku megathrust earthquakes have led to the abandonment of the once-popular concept of a "maximum" earthquake predictable on the basis of simple tectonic parameters and the latter has dealt a serious blow to seismic scaling laws which had been the cornerstone of probabilistic hazard estimations. Similarly, large hurricanes such as Katrina and Sandy have featured a significant diversity poorly captured by the single concept of "category". On the other hand, substantial theoretical progress has been made with the development of real-time tsunami warning algorithms based on the seismic W phase. An examination of mitigation aspects and operational procedures during the recent disasters exposes very significant shortcomings in the relationship between Scientists and decision-makers. We will review fields as diverse as the proper evaluation of historical databases, the correct real-time assessment of major earthquakes, the adequate timing of an all-clear, and the role, rights and duties of hazard scientists in their interaction with Society. As the ultimate goal of mitigation, warning and evacuation from many disasters remains the saving of human lives, many recent stories having emphasized the value of education, which casts a substantial ray of hope and enlightenment in the never-ending pursuit of wisdom in the face of future disasters, a noble endeavor to which Sergei Leonidovich Solov'ev had dedicated his life.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawrence R. Sita

Ferrocene-based molecular components for nanoelectronics offer a number of distinct advantages relative to all carbon frameworks due to metal-centered molecular states that should be closer in energy to the Fermi levels of the metal electrodes in metal / molecule / metal heterojunctions. Given this, the overall goal of the project was to investigate the conduction physics of a variety of proposed ferrocene diode / transistor designs in order to address the fundamental question; can electron transport within nm-length scale structures be modulated in a controlled fashion? During the funded period, substantial progress towards achieving this goal was made by surmountingmore » a number of scientific and technical obstacles. More specifically, a concise and general synthetic route to several mono- and diferrocene dithiols and monothiols was achieved that now allows for the directed and controlled assembly of a variety of metal / molecule /metal test structures for the single molecule conductance measurements and the fabrication of self-assembled monolayers (SAMs) on Au(111) that are amenable to quantitative electrochemical characterization of electron-transfer rates. Most importantly, by using an electromigrated test structure, reproducible I/V data for one of the ferrocene dithiol molecules have been collected which exhibit surprisingly high conductance. Exceptional agreement of this result with theory serves to substantiate the original hypothesis that metal-centered states within a molecular bridge can indeed serve to establish higher conductance relative to all-organic molecular bridges. Overall, the successful demonstration of the ability of ferrocene-molecular frameworks to serve as exceptional molecular conductors will play an important role in the continued evolution in design of molecular components for nanoelectronic devices, which in turn, will have a positive impact on the science and potential technologies associated with these systems.« less

Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia.

PubMed

Rogalski, E; Cobia, D; Harrison, T M; Wieneke, C; Weintraub, S; Mesulam, M-M

2011-05-24

To examine the longitudinal course of primary progressive aphasia (PPA) over a 2-year period and to offer quantitative ranges of expected change that could be used to guide the design and evaluation of therapeutic intervention trials. Regional changes of cortical thickness and whole-brain cortical volume loss as well as neuropsychological language performance were assessed at baseline and 2 years later in 13 rigorously characterized patients who fulfilled research criteria for logopenic, agrammatic, and semantic PPA subtypes (6 PPA-L, 3 PPA-G, and 4 PPA-S). There was substantial progression of clinical deficits and cortical atrophy over 2 years. Neuropsychological language performance patterns lost the sharp distinctions that differentiated one PPA variant from another. Nonetheless, the subtype-specific differential impairment of word comprehension vs grammatical processing was largely maintained. Peak atrophy sites spread beyond the initial distinctive locations that characterized each of the 3 subtypes and displayed a more convergent distribution encompassing all 3 major components of the language network: the inferior frontal gyrus, the temporoparietal junction, and lateral temporal cortex. Despite the progression, overall peak atrophy remained lateralized to the left hemisphere. The results suggest that the unique features, which sharply differentiate the PPA variants at the early to middle stages, may lose their distinctiveness as the degeneration becomes more severe. Given the substantial atrophy over 2 years, PPA clinical trials may require fewer patients and shorter study durations than Alzheimer disease trials to detect significant therapeutic effects.

Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia

PubMed Central

Cobia, D.; Harrison, T.M.; Wieneke, C.; Weintraub, S.; Mesulam, M.-M.

2011-01-01

Objectives: To examine the longitudinal course of primary progressive aphasia (PPA) over a 2-year period and to offer quantitative ranges of expected change that could be used to guide the design and evaluation of therapeutic intervention trials. Methods: Regional changes of cortical thickness and whole-brain cortical volume loss as well as neuropsychological language performance were assessed at baseline and 2 years later in 13 rigorously characterized patients who fulfilled research criteria for logopenic, agrammatic, and semantic PPA subtypes (6 PPA-L, 3 PPA-G, and 4 PPA-S). Results: There was substantial progression of clinical deficits and cortical atrophy over 2 years. Neuropsychological language performance patterns lost the sharp distinctions that differentiated one PPA variant from another. Nonetheless, the subtype-specific differential impairment of word comprehension vs grammatical processing was largely maintained. Peak atrophy sites spread beyond the initial distinctive locations that characterized each of the 3 subtypes and displayed a more convergent distribution encompassing all 3 major components of the language network: the inferior frontal gyrus, the temporoparietal junction, and lateral temporal cortex. Despite the progression, overall peak atrophy remained lateralized to the left hemisphere. Conclusions: The results suggest that the unique features, which sharply differentiate the PPA variants at the early to middle stages, may lose their distinctiveness as the degeneration becomes more severe. Given the substantial atrophy over 2 years, PPA clinical trials may require fewer patients and shorter study durations than Alzheimer disease trials to detect significant therapeutic effects. PMID:21606451

Future European health care: cost containment, health care reform and scientific progress in drug research.

PubMed

Emilien, G

1997-01-01

The cost of the development of a new pharmaceutical product from its conception and synthesis through to the regulatory approval process has more than quadrupled in the last 20 years. Both clinical and total development times have increased substantially. To amortize the costs incurred, the pharmaceutical industry has taken an international dimension. The incentives for pharmaceutical firms to discover and develop new drugs depend on the length of the development and regulatory review process plus the potential market size. Recent regulatory, economic and political changes may have significant implications for the future of new drug developments in Europe. The European Union industrial policy felt that there is a need for convergence in the area of pricing. It is recommended that the policy should aim to contain growth in pharmaceutical expenses by means specific to reimbursement rather than direct price controls. By encouraging doctors to prescribe and customers to use generics, competition is enhanced to bring down drug prices. More emphasis is being laid by government in educating customers to cost-awareness and cost-benefit ratios with regard to pharmaceuticals. Concerning clinical trials, European harmonization has been achieved by significant developments: the rights and integrity of the trial subjects are protected; the credibility of the data is established; and the ethical, scientific and technical quality of the trials has improved. Future European health care forecasts a whole change in the pharmaceutical business. Important issues in cost and outcome measurement should be carefully planned and considered in drug development. Due to important mergers and acquisitions, the pharmaceutical sector will consist mainly of important multinational corporations. In this way, valuable new products may be brought to the market.

Credentialing Data Scientists: A Domain Repository Perspective

NASA Astrophysics Data System (ADS)

Lehnert, K. A.; Furukawa, H.

2015-12-01

A career in data science can have many paths: data curation, data analysis, metadata modeling - all of these in different commercial or scientific applications. Can a certification as 'data scientist' provide the guarantee that an applicant or candidate for a data science position has just the right skills? How valuable is a 'generic' certification as data scientist for an employer looking to fill a data science position? Credentials that are more specific and discipline-oriented may be more valuable to both the employer and the job candidate. One employment sector for data scientists are the data repositories that provide discipline-specific data services for science communities. Data science positions within domain repositories include a wide range of responsibilities in support of the full data life cycle - from data preservation and curation to development of data models, ontologies, and user interfaces, to development of data analysis and visualization tools to community education and outreach, and require a substantial degree of discipline-specific knowledge of scientific data acquisition and analysis workflows, data quality measures, and data cultures. Can there be certification programs for domain-specific data scientists that help build the urgently needed workforce for the repositories? The American Geophysical Union has recently started an initiative to develop a program for data science continuing education and data science professional certification for the Earth and space sciences. An Editorial Board has been charged to identify and develop curricula and content for these programs and to provide input and feedback in the implementation of the program. This presentation will report on the progress of this initiative and evaluate its utility for the needs of domain repositories in the Earth and space sciences.

Interobserver agreement on Poser's and the new McDonald's diagnostic criteria for multiple sclerosis.

PubMed

Zipoli, V; Portaccio, E; Siracusa, G; Pracucci, G; Sorbi, S; Amato, M P

2003-10-01

We assessed the interobserver agreement on the diagnosis of multiple sclerosis (MS) in a study sample consisting of 41 MS (15 relapsing remitting, two secondary progressive, five primary progressive and 19 presenting their first clinical attack) and three non-MS cases. Clinical and paraclinical information was recorded in standardized forms. Four neurologists were asked to make a diagnosis using Poser's and McDonald's criteria and to assess MRI scans according to the McDonald's guidelines. In terms of the kappa statistic (kappa), we found a moderate agreement on the overall diagnosis using both Poser's and McDonald's criteria (kappa, respectively 0.57 and 0.52). As for distinct diagnostic categories, we observed a moderate to substantial agreement for the three McDonald categories (range of kappa values 0.49-0.64) and a fair to substantial agreement for the nine Poser categories (range of kappa values 0.37-0.67). Taking into account clinical information, the agreement on dissemination over time was substantially higher (kappa = 0.69) than that found on dissemination over space (kappa = 0.46). In contrast, for MRI assessment, the agreement for spatial dissemination was substantial (kappa = 0.74) compared with the fair agreement (kappa = 0.25) yielded by dissemination over time. The new McDonald's criteria yield a good overall diagnostic reliability, and compare favourably with Poser's classification in terms of agreement on distinct diagnostic categories.

Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries

PubMed Central

Liu, Ya-Ling; Nascimento, Marcelle; Burne, Robert A

2012-01-01

Alkali production by oral bacteria is believed to have a major impact on oral microbial ecology and to be inibitory to the initiation and progression of dental caries. A substantial body of evidence is beginning to accumulate that indicates the modulation of the alkalinogenic potential of dental biofilms may be a promising strategy for caries control. This brief review highlights recent progress toward understanding molecular genetic and physiologic aspects of important alkali-generating pathways in oral bacteria, and the role of alkali production in the ecology of dental biofilms in health and disease. PMID:22996271

Imaging Cellular Architecture with X-rays

PubMed Central

Larabell, Carolyn A.; Nugent, Keith A.

2012-01-01

X-ray imaging of biological samples is progressing rapidly. In this paper we review the progress to date in high resolution imaging of cellular architecture. In particular we survey the progress in soft X-ray tomography and argue that the field is coming of age and that important biological insights are starting to emerge. We then review the new ideas based on coherent diffraction. These methods are at a much earlier stage of development but, as they eliminate the need for X-ray optics, have the capacity to provide substantially better spatial resolution than zone plate based methods. PMID:20869868

Serious games experiment toward agent-based simulation

USGS Publications Warehouse

Wein, Anne; Labiosa, William

2013-01-01

We evaluate the potential for serious games to be used as a scientifically based decision-support product that supports the United States Geological Survey’s (USGS) mission--to provide integrated, unbiased scientific information that can make a substantial contribution to societal well-being for a wide variety of complex environmental challenges. Serious or pedagogical games are an engaging way to educate decisionmakers and stakeholders about environmental challenges that are usefully informed by natural and social scientific information and knowledge and can be designed to promote interactive learning and exploration in the face of large uncertainties, divergent values, and complex situations. We developed two serious games that use challenging environmental-planning issues to demonstrate and investigate the potential contributions of serious games to inform regional-planning decisions. Delta Skelta is a game emulating long-term integrated environmental planning in the Sacramento-San Joaquin Delta, California, that incorporates natural hazards (flooding and earthquakes) and consequences for California water supplies amidst conflicting water interests. Age of Ecology is a game that simulates interactions between economic and ecologic processes, as well as natural hazards while implementing agent-based modeling. The content of these games spans the USGS science mission areas related to water, ecosystems, natural hazards, land use, and climate change. We describe the games, reflect on design and informational aspects, and comment on their potential usefulness. During the process of developing these games, we identified various design trade-offs involving factual information, strategic thinking, game-winning criteria, elements of fun, number and type of players, time horizon, and uncertainty. We evaluate the two games in terms of accomplishments and limitations. Overall, we demonstrated the potential for these games to usefully represent scientific information within challenging environmental and ecosystem-management contexts and to provide an interactive way of learning about the complexity of interactions between people and natural systems. Further progress on the use of pedagogical games to fulfill the USGS mission will require collaboration among scientists, game developers, educators, and stakeholders. We conclude that as the USGS positions itself to communicate and convey the results of multiple science strategies, including natural-resource security and sustainability, pedagogical game development and agent-based modeling offer a means to (1) establish interdisciplinary and collaborative teams with a focused integrated outcome; (2) contribute to the modeling of interaction, feedback, and adaptation of ecosystems; and (3) enable social learning through a broadly appealing and increasingly sophisticated medium.

Scientific and Technological Progress: Problems for the West.

ERIC Educational Resources Information Center

de Rose, Francois

1978-01-01

Discusses the impact of science and technology on major social problems confronting the Western world. Topics include pollution and ecology, military impact, computer science, and the benefits of science and technology. (Author/MA)

The future of poultry science research: things I think I think.

PubMed

Taylor, R L

2009-06-01

Much poultry research progress has occurred over the first century of the Poultry Science Association. During that time, specific problems have been solved and much basic biological knowledge has been gained. Scientific discovery has exceeded its integration into foundation concepts. Researchers need to be involved in the public's development of critical thinking skills to enable discernment of fact versus fiction. Academic, government, and private institutions need to hire the best people. Issues of insufficient research funding will be remedied by a combination of strategies rather than by a single cure. Scientific advocacy for poultry-related issues is critical to success. Two other keys to the future are funding for higher-risk projects, whose outcome is truly unknown, and specific allocations for new investigators. Diligent, ongoing efforts by poultry scientists will enable progress beyond the challenges.

Create new research directions in comparative endocrinology from Asia and Oceania.

PubMed

Tsutsui, Kazuyoshi

2013-01-15

The Asia and Oceania Society for Comparative Endocrinology (AOSCE) was founded in 1987, when the first congress was held in Nagoya, Japan. The purpose of the AOSCE is to progress scientific activities in the field of comparative endocrinology in Asia and Oceania and to establish a deep relationship among the members. For this purpose, the AOSCE holds a congress or an intercongress symposium every 2 years, which organizes an attractive scientific program covering the latest progress in the broad aspect of comparative endocrinology. 2012 was the 25th anniversary of AOSCE. Our scientific activities have increased dramatically during the past 25 years. The 7th AOSCE congress was held in Kuala Lumpur, Malaysia in 2012. The theme of this congress was "Overcoming challenges in the 21st century". To overcome challenges in the 21st century, we further need to create new research directions in comparative endocrinology from Asia and Oceania. This paper describes a brief history of the AOSCE and also highlights the discovery of gonadotropin-inhibitory hormone (GnIH) and the progress of GnIH research as one of new research directions in comparative endocrinology. In 2000, GnIH was discovered in Japan and now more than 50 laboratories are working on GnIH in the world. The discovery of GnIH has changed our understanding about regulation of the reproductive axis drastically in the past decade. Copyright © 2012 Elsevier Inc. All rights reserved.

76 FR 49412 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Saltmarsh Topminnow...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-10

... Threatened or Endangered Under the Endangered Species Act AGENCY: National Marine Fisheries Service (NMFS... endangered under the Endangered Species Act (ESA). We find that the petition presents substantial scientific.... Endangered Species Act'' because NatureServe assessments ``have different criteria, evidence requirements...

Scientific Presenting: Using Evidence-Based Classroom Practices to Deliver Effective Conference Presentations

ERIC Educational Resources Information Center

Corwin, Lisa A.; Prunuske, Amy; Seidel, Shannon B.

2018-01-01

Scientists and educators travel great distances, spend significant time, and dedicate substantial financial resources to present at conferences. This highlights the value placed on conference interactions. Despite the importance of conferences, very little has been studied about what is learned from the presentations and how presenters can…

Undergraduate Research Involving Deaf and Hard-of-Hearing Students in Interdisciplinary Science Projects

ERIC Educational Resources Information Center

Pagano, Todd; Ross, Annemarie; Smith, Susan B.

2015-01-01

Scientific undergraduate research in higher education often yields positive outcomes for student and faculty member participants alike, with underrepresented students often showing even more substantial gains (academic, professional, and personal) as a result of the experience. Significant success can be realized when involving deaf and…

42 CFR 93.307 - Institutional inquiry.

Code of Federal Regulations, 2012 CFR

2012-10-01

... research records or evidence encompass scientific instruments shared by a number of users, custody may be limited to copies of the data or evidence on such instruments, so long as those copies are substantially equivalent to the evidentiary value of the instruments. (c) Review of evidence. The purpose of an inquiry is...

42 CFR 93.307 - Institutional inquiry.

Code of Federal Regulations, 2013 CFR

2013-10-01

... research records or evidence encompass scientific instruments shared by a number of users, custody may be limited to copies of the data or evidence on such instruments, so long as those copies are substantially equivalent to the evidentiary value of the instruments. (c) Review of evidence. The purpose of an inquiry is...

42 CFR 93.307 - Institutional inquiry.

Code of Federal Regulations, 2011 CFR

2011-10-01

... research records or evidence encompass scientific instruments shared by a number of users, custody may be limited to copies of the data or evidence on such instruments, so long as those copies are substantially equivalent to the evidentiary value of the instruments. (c) Review of evidence. The purpose of an inquiry is...

42 CFR 93.307 - Institutional inquiry.

Code of Federal Regulations, 2010 CFR

2010-10-01

... research records or evidence encompass scientific instruments shared by a number of users, custody may be limited to copies of the data or evidence on such instruments, so long as those copies are substantially equivalent to the evidentiary value of the instruments. (c) Review of evidence. The purpose of an inquiry is...

42 CFR 93.307 - Institutional inquiry.

Code of Federal Regulations, 2014 CFR

2014-10-01

... research records or evidence encompass scientific instruments shared by a number of users, custody may be limited to copies of the data or evidence on such instruments, so long as those copies are substantially equivalent to the evidentiary value of the instruments. (c) Review of evidence. The purpose of an inquiry is...

Overview of Computer Simulation Modeling Approaches and Methods

Treesearch

Robert E. Manning; Robert M. Itami; David N. Cole; Randy Gimblett

2005-01-01

The field of simulation modeling has grown greatly with recent advances in computer hardware and software. Much of this work has involved large scientific and industrial applications for which substantial financial resources are available. However, advances in object-oriented programming and simulation methodology, concurrent with dramatic increases in computer...

Portraits of Fathers. Contemporary Family Trends.

ERIC Educational Resources Information Center

Dubeau, Diane

Noting that a substantial research literature on fathers has been built over the last 20 years and that fathers can no longer be considered "the forgotten parent" of the scientific community, this paper summarizes key research on fathers while highlighting concerns regarding the current emphasis on fatherhood expressed by parents and…

Integrating Science and Literacy Instruction: A Framework for Bridging the Gap

ERIC Educational Resources Information Center

Freeman, Gene; Taylor, Vickie

2006-01-01

There is vast research that substantiates the integration of science and literacy; however, there are very few books that correlate findings and address specific practices. "Integrating Science and Literary Instruction" connects scientifically based research and best instructional practices in literacy and integrates this with the inquiry-based…

7 CFR 3403.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... applications in those fields, who review on an individual basis one or several of the eligible proposals...) Substantially the same research is proposed for funding in more than one grant application submitted to the same... investigator/project director is the one individual designated by the applicant to provide the scientific and...

7 CFR 3403.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... applications in those fields, who review on an individual basis one or several of the eligible proposals...) Substantially the same research is proposed for funding in more than one grant application submitted to the same... investigator/project director is the one individual designated by the applicant to provide the scientific and...

Gender Research in Classrooms: Scientific or Political?

ERIC Educational Resources Information Center

Clarke, John A.; Dart, Barry C.

This paper examines selected Australian studies and studies produced in other countries on gender research of classroom interaction between students and their teachers. The results, deficiencies in methodology, selective reporting of data, and the policies based on the research are highlighted. To substantiate a request for more complex and…

Top 10 Reasons for Quality Physical Education

ERIC Educational Resources Information Center

Le Masurier, Guy; Corbin, Charles B.

2006-01-01

Substantial scientific evidence supports the role of physical activity in disease prevention and healthy lifestyle promotion, and quality physical education represents our best opportunity to provide all children with experiences that promote physical activity now and for a lifetime. The purpose of this article is to document the need for quality…

77 FR 47003 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on Petitions To List the Two Spring...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... the Two Spring Mountains Dark Blue Butterflies and Morand's Checkerspot Butterfly as Endangered or... petitions to list the Spring Mountains dark blue butterflies (Euphilotes ancilla purpura and Euphilotes... dark blue butterflies presents substantial scientific or commercial information indicating that listing...

Evidence-Based and Values-Based Practices for People with Severe Disabilities

ERIC Educational Resources Information Center

Singer, George H. S.; Agran, Martin; Spooner, Fred

2017-01-01

This article discusses the relationship between evidence-based practices (EBPs) and values in research and practice pertaining to people with severe disabilities. The importance of basing educational and habilitation practices on substantial scientific evidence for practical, moral, and legal reasons is acknowledged given the prevalence of…

A 100-year review: Carbohydrates - characterization, digestion, and utilization

USDA-ARS?s Scientific Manuscript database

Our knowledge of the role of carbohydrates in dairy cattle nutrition has advanced substantially during the 100 years in which the Journal of Dairy Science has been published. In this review, we traced the history of scientific investigation and discovery from crude fiber, nitrogen-free extract, and ...

49 CFR 106.100 - Required information for a petition for rulemaking.

Code of Federal Regulations, 2013 CFR

2013-10-01

... of your proposed action on small businesses, small organizations, small governmental jurisdictions... scientific data available to you. (5) Any specific cases that support or demonstrate the need for your proposed action. (b) If the impact of your proposed action is substantial, and data or other information...

49 CFR 106.100 - Required information for a petition for rulemaking.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of your proposed action on small businesses, small organizations, small governmental jurisdictions... scientific data available to you. (5) Any specific cases that support or demonstrate the need for your proposed action. (b) If the impact of your proposed action is substantial, and data or other information...

49 CFR 106.100 - Required information for a petition for rulemaking.

Code of Federal Regulations, 2014 CFR

2014-10-01

... of your proposed action on small businesses, small organizations, small governmental jurisdictions... scientific data available to you. (5) Any specific cases that support or demonstrate the need for your proposed action. (b) If the impact of your proposed action is substantial, and data or other information...

49 CFR 106.100 - Required information for a petition for rulemaking.

Code of Federal Regulations, 2012 CFR

2012-10-01

... of your proposed action on small businesses, small organizations, small governmental jurisdictions... scientific data available to you. (5) Any specific cases that support or demonstrate the need for your proposed action. (b) If the impact of your proposed action is substantial, and data or other information...

What Evidence Says about Reading Recovery.

ERIC Educational Resources Information Center

Reading Recovery Council of North America, Columbus, OH.

Reading Recovery (RR) is a short-term intervention for the lowest-achieving children in first grade. Children meet individually with a specially trained teacher for 30 minutes daily for 12 to 20 weeks. There is substantial scientific evidence to support Reading Recovery's effectiveness with the lowest-performing first-grade students. Reading…

FOCUSING ON CHILDREN'S INHALATION DOSIMETRY AND HEALTH EFFECTS FOR RISK ASSESSMENT: AN INTRODUCTION (Journal Article)

EPA Science Inventory

Substantial effort has been invested in improving children’s health risk assessment in recent years. However, the body of scientific evidence in support of children’s health assessment is constantly advancing requiring continual updating of risk assessment methods. Children’s i...

Progression of Inflammatory Bowel Disease to Cancer: Is the Patient Better Off without Lymphatic Vessels or Nodes (or Angiopoietin 2)?

DTIC Science & Technology

2013-12-01

carcinoma (CRC) in IBD patients and experimental models. Nonetheless, the pathogenic link, interrelationship, and practical clinical application of these...and are continuing final data analysis and latest imaging studies. This project has potentially high impact because of the substantial incidence of...pathogenic link, interrelationship, and practical clinical application of these various theories of progression have remained elusive. We proposed that

Early Rockets

NASA Image and Video Library

1940-03-21

Goddard rocket in launching tower at Roswell, New Mexico, March 21, 1940. Fuel was injected by pumps from the fueling platform at left. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

Early Rockets

NASA Image and Video Library

2004-04-15

Goddard rocket with four rocket motors. This rocket attained an altitude of 200 feet in a flight, November 1936, at Roswell, New Mexico. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology