Microlensing makes lensed quasar time delays significantly time variable

NASA Astrophysics Data System (ADS)

Tie, S. S.; Kochanek, C. S.

2018-01-01

The time delays of gravitationally lensed quasars are generally believed to be unique numbers whose measurement is limited only by the quality of the light curves and the models for the contaminating contribution of gravitational microlensing to the light curves. This belief is incorrect - gravitational microlensing also produces changes in the actual time delays on the ∼day(s) light-crossing time-scale of the emission region. This is due to a combination of the inclination of the disc relative to the line of sight and the differential magnification of the temperature fluctuations producing the variability. We demonstrate this both mathematically and with direct calculations using microlensing magnification patterns. Measuring these delay fluctuations can provide a physical scale for microlensing observations, removing the need for priors on either the microlens masses or the component velocities. That time delays in lensed quasars are themselves time variable likely explains why repeated delay measurements of individual lensed quasars appear to vary by more than their estimated uncertainties. This effect is also a new important systematic problem for attempts to use time delays in lensed quasars for cosmology or to detect substructures (satellites) in lens galaxies.

iPTF16geu: A multiply imaged, gravitationally lensed type Ia supernova

DOE PAGES

Goobar, A.; Amanullah, R.; Kulkarni, S. R.; ...

2017-04-21

We report the discovery of a multiply imaged, gravitationally lensed type Ia supernova, iPTF16geu (SN 2016geu), at redshift z = 0.409. This phenomenon was identified because the light from the stellar explosion was magnified more than 50 times by the curvature of space around matter in an intervening galaxy.We used high-spatial-resolution observations to resolve four images of the lensed supernova, approximately 0.3 arc seconds from the center of the foreground galaxy. The observations probe a physical scale of ~1 kiloparsec, smaller than is typical in other studies of extragalactic gravitational lensing. The large magnification and symmetric image configuration imply closemore » alignment between the lines of sight to the supernova and to the lens. In conclusion, the relative magnifications of the four images provide evidence for substructures in the lensing galaxy.« less

iPTF16geu: A multiply imaged, gravitationally lensed type Ia supernova.

PubMed

Goobar, A; Amanullah, R; Kulkarni, S R; Nugent, P E; Johansson, J; Steidel, C; Law, D; Mörtsell, E; Quimby, R; Blagorodnova, N; Brandeker, A; Cao, Y; Cooray, A; Ferretti, R; Fremling, C; Hangard, L; Kasliwal, M; Kupfer, T; Lunnan, R; Masci, F; Miller, A A; Nayyeri, H; Neill, J D; Ofek, E O; Papadogiannakis, S; Petrushevska, T; Ravi, V; Sollerman, J; Sullivan, M; Taddia, F; Walters, R; Wilson, D; Yan, L; Yaron, O

2017-04-21

We report the discovery of a multiply imaged, gravitationally lensed type Ia supernova, iPTF16geu (SN 2016geu), at redshift z = 0.409. This phenomenon was identified because the light from the stellar explosion was magnified more than 50 times by the curvature of space around matter in an intervening galaxy. We used high-spatial-resolution observations to resolve four images of the lensed supernova, approximately 0.3 arc seconds from the center of the foreground galaxy. The observations probe a physical scale of ~1 kiloparsec, smaller than is typical in other studies of extragalactic gravitational lensing. The large magnification and symmetric image configuration imply close alignment between the lines of sight to the supernova and to the lens. The relative magnifications of the four images provide evidence for substructures in the lensing galaxy. Copyright © 2017, American Association for the Advancement of Science.

Substructures in DAFT/FADA survey clusters based on XMM and optical data

NASA Astrophysics Data System (ADS)

Durret, F.; DAFT/FADA Team

2014-07-01

The DAFT/FADA survey was initiated to perform weak lensing tomography on a sample of 90 massive clusters in the redshift range [0.4,0.9] with HST imaging available. The complementary deep multiband imaging constitutes a high quality imaging data base for these clusters. In X-rays, we have analysed the XMM-Newton and/or Chandra data available for 32 clusters, and for 23 clusters we fit the X-ray emissivity with a beta-model and subtract it to search for substructures in the X-ray gas. This study was coupled with a dynamical analysis for the 18 clusters with at least 15 spectroscopic galaxy redshifts in the cluster range, based on a Serna & Gerbal (SG) analysis. We detected ten substructures in eight clusters by both methods (X-rays and SG). The percentage of mass included in substructures is found to be roughly constant with redshift, with values of 5-15%. Most of the substructures detected both in X-rays and with the SG method are found to be relatively recent infalls, probably at their first cluster pericenter approach.

Weak lensing calibration of mass bias in the REFLEX+BCS X-ray galaxy cluster catalogue

NASA Astrophysics Data System (ADS)

Simet, Melanie; Battaglia, Nicholas; Mandelbaum, Rachel; Seljak, Uroš

2017-04-01

The use of large, X-ray-selected Galaxy cluster catalogues for cosmological analyses requires a thorough understanding of the X-ray mass estimates. Weak gravitational lensing is an ideal method to shed light on such issues, due to its insensitivity to the cluster dynamical state. We perform a weak lensing calibration of 166 galaxy clusters from the REFLEX and BCS cluster catalogue and compare our results to the X-ray masses based on scaled luminosities from that catalogue. To interpret the weak lensing signal in terms of cluster masses, we compare the lensing signal to simple theoretical Navarro-Frenk-White models and to simulated cluster lensing profiles, including complications such as cluster substructure, projected large-scale structure and Eddington bias. We find evidence of underestimation in the X-ray masses, as expected, with = 0.75 ± 0.07 stat. ±0.05 sys. for our best-fitting model. The biases in cosmological parameters in a typical cluster abundance measurement that ignores this mass bias will typically exceed the statistical errors.

The effects of structure anisotropy on lensing observables in an exact general relativistic setting for precision cosmology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Troxel, M. A.; Ishak, Mustapha; Peel, Austin, E-mail: troxel@utdallas.edu, E-mail: mishak@utdallas.edu, E-mail: austin.peel@utdallas.edu

2014-03-01

The study of relativistic, higher order, and nonlinear effects has become necessary in recent years in the pursuit of precision cosmology. We develop and apply here a framework to study gravitational lensing in exact models in general relativity that are not restricted to homogeneity and isotropy, and where full nonlinearity and relativistic effects are thus naturally included. We apply the framework to a specific, anisotropic galaxy cluster model which is based on a modified NFW halo density profile and described by the Szekeres metric. We examine the effects of increasing levels of anisotropy in the galaxy cluster on lensing observablesmore » like the convergence and shear for various lensing geometries, finding a strong nonlinear response in both the convergence and shear for rays passing through anisotropic regions of the cluster. Deviation from the expected values in a spherically symmetric structure are asymmetric with respect to path direction and thus will persist as a statistical effect when averaged over some ensemble of such clusters. The resulting relative difference in various geometries can be as large as approximately 2%, 8%, and 24% in the measure of convergence (1−κ) for levels of anisotropy of 5%, 10%, and 15%, respectively, as a fraction of total cluster mass. For the total magnitude of shear, the relative difference can grow near the center of the structure to be as large as 15%, 32%, and 44% for the same levels of anisotropy, averaged over the two extreme geometries. The convergence is impacted most strongly for rays which pass in directions along the axis of maximum dipole anisotropy in the structure, while the shear is most strongly impacted for rays which pass in directions orthogonal to this axis, as expected. The rich features found in the lensing signal due to anisotropic substructure are nearly entirely lost when one treats the cluster in the traditional FLRW lensing framework. These effects due to anisotropic structures are thus likely to impact lensing measurements and must be fully examined in an era of precision cosmology.« less

IDENTIFYING ANOMALIES IN GRAVITATIONAL LENS TIME DELAYS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Congdon, Arthur B.; Keeton, Charles R.; Nordgren, C. Erik, E-mail: acongdon@jpl.nasa.go, E-mail: keeton@physics.rutgers.ed, E-mail: nordgren@sas.upenn.ed

2010-02-01

We examine the ability of gravitational lens time delays to reveal complex structure in lens potentials. In a previous paper, we predicted how the time delay between the bright pair of images in a 'fold' lens scales with the image separation, for smooth lens potentials. Here we show that the proportionality constant increases with the quadrupole moment of the lens potential, and depends only weakly on the position of the source along the caustic. We use Monte Carlo simulations to determine the range of time delays that can be produced by realistic smooth lens models consisting of isothermal ellipsoid galaxiesmore » with tidal shear. We can then identify outliers as 'time delay anomalies'. We find evidence for anomalies in close image pairs in the cusp lenses RX J1131 - 1231 and B1422+231. The anomalies in RX J1131 - 1231 provide strong evidence for substructure in the lens potential, while at this point the apparent anomalies in B1422+231 mainly indicate that the time delay measurements need to be improved. We also find evidence for time delay anomalies in larger-separation image pairs in the fold lenses, B1608+656 and WFI 2033 - 4723, and the cusp lens RX J0911+0551. We suggest that these anomalies are caused by some combination of substructure and a complex lens environment. Finally, to assist future monitoring campaigns we use our smooth models with shear to predict the time delays for all known four-image lenses.« less

Identifying Anomalies in Gravitational Lens Time Delays

NASA Astrophysics Data System (ADS)

Congdon, Arthur B.; Keeton, Charles R.; Nordgren, C. Erik

2010-02-01

We examine the ability of gravitational lens time delays to reveal complex structure in lens potentials. In a previous paper, we predicted how the time delay between the bright pair of images in a "fold" lens scales with the image separation, for smooth lens potentials. Here we show that the proportionality constant increases with the quadrupole moment of the lens potential, and depends only weakly on the position of the source along the caustic. We use Monte Carlo simulations to determine the range of time delays that can be produced by realistic smooth lens models consisting of isothermal ellipsoid galaxies with tidal shear. We can then identify outliers as "time delay anomalies." We find evidence for anomalies in close image pairs in the cusp lenses RX J1131 - 1231 and B1422+231. The anomalies in RX J1131 - 1231 provide strong evidence for substructure in the lens potential, while at this point the apparent anomalies in B1422+231 mainly indicate that the time delay measurements need to be improved. We also find evidence for time delay anomalies in larger-separation image pairs in the fold lenses, B1608+656 and WFI 2033 - 4723, and the cusp lens RX J0911+0551. We suggest that these anomalies are caused by some combination of substructure and a complex lens environment. Finally, to assist future monitoring campaigns we use our smooth models with shear to predict the time delays for all known four-image lenses.

Dark Matter under the Microscope: Constraining Compact Dark Matter with Caustic Crossing Events

NASA Astrophysics Data System (ADS)

Diego, Jose M.; Kaiser, Nick; Broadhurst, Tom; Kelly, Patrick L.; Rodney, Steve; Morishita, Takahiro; Oguri, Masamune; Ross, Timothy W.; Zitrin, Adi; Jauzac, Mathilde; Richard, Johan; Williams, Liliya; Vega-Ferrero, Jesus; Frye, Brenda; Filippenko, Alexei V.

2018-04-01

A galaxy cluster acts as a cosmic telescope over background galaxies but also as a cosmic microscope magnifying the imperfections of the lens. The diverging magnification of lensing caustics enhances the microlensing effect of substructure present within the lensing mass. Fine-scale structure can be accessed as a moving background source brightens and disappears when crossing these caustics. The recent discovery of a distant lensed star near the Einstein radius of the galaxy cluster MACSJ1149.5+2223 allows a rare opportunity to reach subsolar-mass microlensing through a supercritical column of cluster matter. Here we compare these observations with high-resolution ray-tracing simulations that include stellar microlensing set by the observed intracluster starlight and also primordial black holes that may be responsible for the recently observed LIGO events. We explore different scenarios with microlenses from the intracluster medium and black holes, including primordial ones, and examine strategies to exploit these unique alignments. We find that the best constraints on the fraction of compact dark matter (DM) in the small-mass regime can be obtained in regions of the cluster where the intracluster medium plays a negligible role. This new lensing phenomenon should be widespread and can be detected within modest-redshift lensed galaxies so that the luminosity distance is not prohibitive for detecting individual magnified stars. High-cadence Hubble Space Telescope monitoring of several such optimal arcs will be rewarded by an unprecedented mass spectrum of compact objects that can contribute to uncovering the nature of DM.

Discovery of the First Quadruple Gravitationally Lensed Quasar Candidate with Pan-STARRS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berghea, C. T.; Nelson, George J.; Dudik, R. P.

We report the serendipitous discovery of the first gravitationally lensed quasar candidate from Pan-STARRS. The grizy images reveal four point-like images with magnitudes between 14.9 and 18.1 mag. The colors of the point sources are similar, and they are more consistent with quasars than with stars or galaxies. The lensing galaxy is detected in the izy bands, with an inferred photometric redshift of ∼0.6, lower than that of the point sources. We successfully model the system with a singular isothermal ellipsoid with shear, using the relative positions of the five objects as constraints. While the brightness ranking of the pointmore » sources is consistent with that of the model, we find discrepancies between the model-predicted and observed fluxes, likely due to microlensing by stars and millilensing due to the dark matter substructure. In order to fully confirm the gravitational lens nature of this system and add it to the small but growing number of the powerful probes of cosmology and astrophysics represented by quadruply lensed quasars, we require further spectroscopy and high-resolution imaging.« less

Correction of Hydrostatic Cluster Masses through Power Ratios and Weak Lensing

NASA Astrophysics Data System (ADS)

Mahdavi, Andisheh

2009-09-01

The evolution of rich, X-ray emitting clusters of galaxies has given us precise measurements of the cosmological parameters, with dramatic constraints on the dark energy equation of state. Built into these measurements are wholesale corrections for the infamous "X-ray mass underestimate"---the fact that X-ray masses are systematically low due to the incomplete thermalization of the intracluster plasma. We seek to refine the mass correction for cosmological use through morphological power ratios. Power ratios deliver more accurate correction factors because they take into account variations in substructure from cluster to cluster. We will test their ability to correct X-ray masses by comparing hydrostatic and weak lensing mass profiles for a sample of 44 rich clusters of galaxies.

MC 2: A Deeper Look at ZwCl 2341.1+0000 with Bayesian Galaxy Clustering and Weak Lensing Analyses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benson, B.; Wittman, D. M.; Golovich, N.

ZwCl 2341.1+0000, a merging galaxy cluster with disturbed X-ray morphology and widely separated (~3 Mpc) double radio relics, was thought to be an extremely massive (10 - 30 X 10 14M⊙) and complex system with little known about its merger history. We present JVLA 2-4 GHz observations of the cluster, along with new spectroscopy from our Keck/DEIMOS survey, and apply Gaussian Mixture Modeling to the three-dimensional distribution of 227 con rmed cluster galaxies. After adopting the Bayesian Information Criterion to avoid over tting, which we discover can bias total dynamical mass estimates high, we nd that a three-substructure model withmore » a total dynamical mass estimate of 9:39 ± 0:81 X 10 14M⊙ is favored. We also present deep Subaru imaging and perform the rst weak lensing analysis on this system, obtaining a weak lensing mass estimate of 5:57±2:47X10 14M⊙. This is a more robust estimate because it does not depend on the dynamical state of the system, which is disturbed due to the merger. Our results indicate that ZwCl 2341.1+0000 is a multiple merger system comprised of at least three substructures, with the main merger that produced the radio relics occurring near to the plane of the sky, and a younger merger in the North occurring closer to the line of sight. Dynamical modeling of the main merger reproduces observed quantities (relic positions and polarizations, subcluster separation and radial velocity difference), if the merger axis angle of ~10 +34 -6 degrees and the collision speed at pericenter is ~1900 +300 -200 km/s.« less

MC 2: A Deeper Look at ZwCl 2341.1+0000 with Bayesian Galaxy Clustering and Weak Lensing Analyses

DOE PAGES

Benson, B.; Wittman, D. M.; Golovich, N.; ...

2017-05-16

ZwCl 2341.1+0000, a merging galaxy cluster with disturbed X-ray morphology and widely separated (~3 Mpc) double radio relics, was thought to be an extremely massive (10 - 30 X 10 14M⊙) and complex system with little known about its merger history. We present JVLA 2-4 GHz observations of the cluster, along with new spectroscopy from our Keck/DEIMOS survey, and apply Gaussian Mixture Modeling to the three-dimensional distribution of 227 con rmed cluster galaxies. After adopting the Bayesian Information Criterion to avoid over tting, which we discover can bias total dynamical mass estimates high, we nd that a three-substructure model withmore » a total dynamical mass estimate of 9:39 ± 0:81 X 10 14M⊙ is favored. We also present deep Subaru imaging and perform the rst weak lensing analysis on this system, obtaining a weak lensing mass estimate of 5:57±2:47X10 14M⊙. This is a more robust estimate because it does not depend on the dynamical state of the system, which is disturbed due to the merger. Our results indicate that ZwCl 2341.1+0000 is a multiple merger system comprised of at least three substructures, with the main merger that produced the radio relics occurring near to the plane of the sky, and a younger merger in the North occurring closer to the line of sight. Dynamical modeling of the main merger reproduces observed quantities (relic positions and polarizations, subcluster separation and radial velocity difference), if the merger axis angle of ~10 +34 -6 degrees and the collision speed at pericenter is ~1900 +300 -200 km/s.« less

Halo Substructure and the Power Spectrum

NASA Astrophysics Data System (ADS)

Zentner, Andrew R.; Bullock, James S.

2003-11-01

We present a semianalytic model to investigate the merger history, destruction rate, and survival probability of substructure in hierarchically formed dark matter halos and use it to study the substructure content of halos as a function of input primordial power spectrum. For a standard cold dark matter ``concordance'' cosmology (ΛCDM n=1, σ8=0.95) we successfully reproduce the subhalo velocity function and radial distribution profile seen in N-body simulations and determine that the rate of merging and disruption peaks ~10-12 Gyr in the past for Milky Way-like halos, while surviving substructures are typically accreted within the last ~0-8 Gyr. We explore power spectra with normalizations and spectral ``tilts'' spanning the ranges σ8~=1-0.65 and n~=1-0.8, and include a ``running-index'' model with dn/dlnk=-0.03 similar to the best-fit model discussed in the first-year Wilkinson Microwave Anisotropy Probe (WMAP) report. We investigate spectra with truncated small-scale power, including a broken-scale inflation model and three warm dark matter cases with mW=0.75-3.0 keV. We find that the mass fraction in substructure is relatively insensitive to the tilt and overall normalization of the primordial power spectrum. All of the CDM-type models yield projected substructure mass fractions that are consistent with, but on the low side, of published estimates from strong lens systems: f9=0.4%-1.5% (64th percentile) for subhalos smaller than 109 Msolar within projected cylinders of radius r<10 kpc. Truncated models produce significantly smaller fractions, f9=0.02%-0.2% for mW~=1 keV, and are disfavored by lensing estimates. This suggests that lensing and similar probes can provide a robust test of the CDM paradigm and a powerful constraint on broken-scale inflation/warm particle masses, including masses larger than the ~1 keV upper limits of previous studies. We compare our predicted subhalo velocity functions with the dwarf satellite population of the Milky Way. Assuming that dwarfs have isotropic velocity dispersions, we find that the standard n=1 model overpredicts the number of Milky Way satellites at Vmax<~35 km s-1, as expected. Models with less small-scale power do better because subhalos are less concentrated and the mapping between observed velocity dispersion and halo Vmax is significantly altered. The running-index model, or a fixed tilt with σ8~0.75, can account for the local dwarfs without the need for differential feedback (for Vmax>~20 km s-1) however, these comparisons depend sensitively on the assumption of isotropic velocities in satellite galaxies.

CLASH-VLT: INSIGHTS ON THE MASS SUBSTRUCTURES IN THE FRONTIER FIELDS CLUSTER MACS J0416.1–2403 THROUGH ACCURATE STRONG LENS MODELING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grillo, C.; Suyu, S. H.; Umetsu, K.

2015-02-10

We present a detailed mass reconstruction and a novel study on the substructure properties in the core of the Cluster Lensing And Supernova survey with Hubble (CLASH) and Frontier Fields galaxy cluster MACS J0416.1–2403. We show and employ our extensive spectroscopic data set taken with the VIsible Multi-Object Spectrograph instrument as part of our CLASH-VLT program, to confirm spectroscopically 10 strong lensing systems and to select a sample of 175 plausible cluster members to a limiting stellar mass of log (M {sub *}/M {sub ☉}) ≅ 8.6. We reproduce the measured positions of a set of 30 multiple images withmore » a remarkable median offset of only 0.''3 by means of a comprehensive strong lensing model comprised of two cluster dark-matter halos, represented by cored elliptical pseudo-isothermal mass distributions, and the cluster member components, parameterized with dual pseudo-isothermal total mass profiles. The latter have total mass-to-light ratios increasing with the galaxy HST/WFC3 near-IR (F160W) luminosities. The measurement of the total enclosed mass within the Einstein radius is accurate to ∼5%, including the systematic uncertainties estimated from six distinct mass models. We emphasize that the use of multiple-image systems with spectroscopic redshifts and knowledge of cluster membership based on extensive spectroscopic information is key to constructing robust high-resolution mass maps. We also produce magnification maps over the central area that is covered with HST observations. We investigate the galaxy contribution, both in terms of total and stellar mass, to the total mass budget of the cluster. When compared with the outcomes of cosmological N-body simulations, our results point to a lack of massive subhalos in the inner regions of simulated clusters with total masses similar to that of MACS J0416.1–2403. Our findings of the location and shape of the cluster dark-matter halo density profiles and on the cluster substructures provide intriguing tests of the assumed collisionless, cold nature of dark matter and of the role played by baryons in the process of structure formation.« less

Glimpse: Sparsity based weak lensing mass-mapping tool

NASA Astrophysics Data System (ADS)

Lanusse, F.; Starck, J.-L.; Leonard, A.; Pires, S.

2018-02-01

Glimpse, also known as Glimpse2D, is a weak lensing mass-mapping tool that relies on a robust sparsity-based regularization scheme to recover high resolution convergence from either gravitational shear alone or from a combination of shear and flexion. Including flexion allows the supplementation of the shear on small scales in order to increase the sensitivity to substructures and the overall resolution of the convergence map. To preserve all available small scale information, Glimpse avoids any binning of the irregularly sampled input shear and flexion fields and treats the mass-mapping problem as a general ill-posed inverse problem, regularized using a multi-scale wavelet sparsity prior. The resulting algorithm incorporates redshift, reduced shear, and reduced flexion measurements for individual galaxies and is made highly efficient by the use of fast Fourier estimators.

Reconstruction of cluster masses using particle based lensing

NASA Astrophysics Data System (ADS)

Deb, Sanghamitra

Clusters of galaxies are among the richest astrophysical data systems, but to truly understand these systems, we need a detailed study of the relationship between observables and the underlying cluster dark matter distribution. Gravitational lensing is the most direct probe of dark matter, but many mass reconstruction techniques assume that cluster light traces mass, or combine different lensing signals in an ad hoc way. In this talk, we will describe "Particle Based Lensing" (PBL), a new method for cluster mass reconstruction, that avoids many of the pitfalls of previous techniques. PBL optimally combines lensing information of varying signal-to-noise, and makes no assumptions about the relationship between mass and light. We will describe mass reconstructions in three very different, but very illuminating cluster systems: the "Bullet Cluster" (lE 0657-56), A901/902 and A1689. The "Bullet Cluster" is a system of merging clusters made famous by the first unambiguous lensing detection of dark matter. A901/902 is a multi-cluster system with four peaks, and provides an ideal laboratory for studying cluster interaction. We are particularly interested in measuring and correlating the dark matter clump ellipticities. A1689 is one of the richest clusters known, and has significant substructure at the core. It is also my first exercise in optimally combining weak and strong gravitational lensing in a cluster reconstruction. We find that the dark matter distribution is significantly clumpier than indicated by X-ray maps of the gas. We conclude by discussing various potential applications of PBL to existing and future data.

THE BOSS EMISSION-LINE LENS SURVEY. IV. SMOOTH LENS MODELS FOR THE BELLS GALLERY SAMPLE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shu, Yiping; Bolton, Adam S.; Montero-Dorta, Antonio D.

We present Hubble Space Telescope F606W-band imaging observations of 21 galaxy-Ly α emitter lens candidates in the Baryon Oscillation Spectroscopic Survey Emission-Line Lens Survey (BELLS) for the GALaxy-Ly α EmitteR sYstems (BELLS GALLERY) survey. Seventeen systems are confirmed to be definite lenses with unambiguous evidence of multiple imaging. The lenses are primarily massive early-type galaxies (ETGs) at redshifts of approximately 0.55, while the lensed sources are Ly α emitters (LAEs) at redshifts from two to three. Although most of the lens systems are well fit by smooth lens models consisting of singular isothermal ellipsoids in an external shear field, a thoroughmore » exploration of dark substructures in the lens galaxies is required. The Einstein radii of the BELLS GALLERY lenses are, on average, 60% larger than those of the BELLS lenses because of the much higher source redshifts. This will allow for a detailed investigation of the radius evolution of the mass profile in ETGs. With the aid of the average ∼13× lensing magnification, the LAEs are frequently resolved into individual star-forming knots with a wide range of properties. They have characteristic sizes from less than 100 pc to several kiloparsecs, rest-frame far-UV apparent AB magnitudes from 29.6 to 24.2, and typical projected separations of 500 pc to 2 kpc.« less

LoCuSS: Testing hydrostatic equilibrium in galaxy clusters

NASA Astrophysics Data System (ADS)

Smith, G. P.; Mazzotta, P.; Okabe, N.; Ziparo, F.; Mulroy, S. L.; Babul, A.; Finoguenov, A.; McCarthy, I. G.; Lieu, M.; Bahé, Y. M.; Bourdin, H.; Evrard, A. E.; Futamase, T.; Haines, C. P.; Jauzac, M.; Marrone, D. P.; Martino, R.; May, P. E.; Taylor, J. E.; Umetsu, K.

2016-02-01

We test the assumption of hydrostatic equilibrium in an X-ray luminosity selected sample of 50 galaxy clusters at 0.15 < z < 0.3 from the Local Cluster Substructure Survey (LoCuSS). Our weak-lensing measurements of M500 control systematic biases to sub-4 per cent, and our hydrostatic measurements of the same achieve excellent agreement between XMM-Newton and Chandra. The mean ratio of X-ray to lensing mass for these 50 clusters is β_X= 0.95± 0.05, and for the 44 clusters also detected by Planck, the mean ratio of Planck mass estimate to LoCuSS lensing mass is β_P= 0.95± 0.04. Based on a careful like-for-like analysis, we find that LoCuSS, the Canadian Cluster Comparison Project, and Weighing the Giants agree on β_P ≃ 0.9-0.95 at 0.15 < z < 0.3. This small level of hydrostatic bias disagrees at ˜5σ with the level required to reconcile Planck cosmology results from the cosmic microwave background and galaxy cluster counts.

A Spectroscopically Confirmed Double Source Plane Lens System in the Hyper Suprime-Cam Subaru Strategic Program

NASA Astrophysics Data System (ADS)

Tanaka, Masayuki; Wong, Kenneth C.; More, Anupreeta; Dezuka, Arsha; Egami, Eiichi; Oguri, Masamune; Suyu, Sherry H.; Sonnenfeld, Alessandro; Higuchi, Ryo; Komiyama, Yutaka; Miyazaki, Satoshi; Onoue, Masafusa; Oyamada, Shuri; Utsumi, Yousuke

2016-08-01

We report the serendipitous discovery of HSC J142449-005322, a double source plane lens system in the Hyper Suprime-Cam Subaru Strategic Program. We dub the system Eye of Horus. The lens galaxy is a very massive early-type galaxy with stellar mass of ˜ 7× {10}11 {M}⊙ located at {z}{{L}}=0.795. The system exhibits two arcs/rings with clearly different colors, including several knots. We have performed spectroscopic follow-up observations of the system with FIRE on Magellan. The outer ring is confirmed at {z}{{S}2}=1.988 with multiple emission lines, while the inner arc and counterimage is confirmed at {z}{{S}1}=1.302. This makes it the first double source plane system with spectroscopic redshifts of both sources. Interestingly, redshifts of two of the knots embedded in the outer ring are found to be offset by {{Δ }}z=0.002 from the other knots, suggesting that the outer ring consists of at least two distinct components in the source plane. We perform lens modeling with two independent codes and successfully reproduce the main features of the system. However, two of the lensed sources separated by ˜0.7 arcsec cannot be reproduced by a smooth potential, and the addition of substructure to the lens potential is required to reproduce them. Higher-resolution imaging of the system will help decipher the origin of this lensing feature and potentially detect the substructure.

MC2: Subaru and Hubble Space Telescope Weak-lensing Analysis of the Double Radio Relic Galaxy Cluster PLCK G287.0+32.9

NASA Astrophysics Data System (ADS)

Finner, Kyle; Jee, M. James; Golovich, Nathan; Wittman, David; Dawson, William; Gruen, Daniel; Koekemoer, Anton M.; Lemaux, Brian C.; Seitz, Stella

2017-12-01

The second most significant detection of the Planck Sunyaev‑Zel’dovich survey, PLCK G287.0+32.9 (z = 0.385), boasts two similarly bright radio relics and a radio halo. One radio relic is located ∼ 400 {kpc} NW of the X-ray peak and the other ∼ 2.8 Mpc to the SE. This large difference suggests that a complex merging scenario is required. A key missing puzzle for the merging scenario reconstruction is the underlying dark matter distribution in high resolution. We present a joint Subaru Telescope and Hubble Space Telescope weak-lensing analysis of the cluster. Our analysis shows that the mass distribution features four significant substructures. Of the substructures, a primary cluster of mass {M}200{{c}}={1.59}-0.22+0.25× {10}15 {h}70-1 {M}ȯ dominates the weak-lensing signal. This cluster is likely to be undergoing a merger with one (or more) subcluster whose mass is approximately a factor of 10 lower. One candidate is the subcluster of mass {M}200{{c}}={1.16}-0.13+0.15× {10}14 {h}70-1 {M}ȯ located ∼ 400 {kpc} to the SE. The location of this subcluster suggests that its interaction with the primary cluster could be the source of the NW radio relic. Another subcluster is detected ∼ 2 Mpc to the SE of the X-ray peak with mass {M}200{{c}}={1.68}-0.20+0.22× {10}14 {h}70-1 {M}ȯ . This SE subcluster is in the vicinity of the SE radio relic and may have created the SE radio relic during a past merger with the primary cluster. The fourth subcluster, {M}200{{c}}={1.87}-0.22+0.24× {10}14 {h}70-1 {M}ȯ , is NW of the X-ray peak and beyond the NW radio relic.

LoCuSS: A COMPARISON OF SUNYAEV-ZEL'DOVICH EFFECT AND GRAVITATIONAL-LENSING MEASUREMENTS OF GALAXY CLUSTERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marrone, Daniel P.; Culverhouse, Thomas; Carlstrom, John E.

2009-08-20

We present the first measurement of the relationship between the Sunyaev-Zel'dovich effect (SZE) signal and the mass of galaxy clusters that uses gravitational lensing to measure cluster mass, based on 14 X-ray luminous clusters at z {approx_equal} 0.2 from the Local Cluster Substructure Survey. We measure the integrated Compton y-parameter, Y, and total projected mass of the clusters (M {sub GL}) within a projected clustercentric radius of 350 kpc, corresponding to mean overdensities of 4000-8000 relative to the critical density. We find self-similar scaling between M {sub GL} and Y, with a scatter in mass at fixed Y of 32%.more » This scatter exceeds that predicted from numerical cluster simulations, however, it is smaller than comparable measurements of the scatter in mass at fixed T{sub X} . We also find no evidence of segregation in Y between disturbed and undisturbed clusters, as had been seen with T{sub X} on the same physical scales. We compare our scaling relation to the Bonamente et al. relation based on mass measurements that assume hydrostatic equilibrium, finding no evidence for a hydrostatic mass bias in cluster cores (M {sub GL} = 0.98 {+-} 0.13 M {sub HSE}), consistent with both predictions from numerical simulations and lensing/X-ray-based measurements of mass-observable scaling relations at larger radii. Overall our results suggest that the SZE may be less sensitive than X-ray observations to the details of cluster physics in cluster cores.« less

The CAnadian NIRISS Unbiased Cluster Survey (CANUCS)

NASA Astrophysics Data System (ADS)

Ravindranath, Swara; NIRISS GTO Team

2017-06-01

CANUCS GTO program is a JWST spectroscopy and imaging survey of five massive galaxy clusters and ten parallel fields using the NIRISS low-resolution grisms, NIRCam imaging and NIRSpec multi-object spectroscopy. The primary goal is to understand the evolution of low mass galaxies across cosmic time. The resolved emission line maps and line ratios for many galaxies, with some at resolution of 100pc via the magnification by gravitational lensing will enable determining the spatial distribution of star formation, dust and metals. Other science goals include the detection and characterization of galaxies within the reionization epoch, using multiply-imaged lensed galaxies to constrain cluster mass distributions and dark matter substructure, and understanding star-formation suppression in the most massive galaxy clusters. In this talk I will describe the science goals of the CANUCS program. The proposed prime and parallel observations will be presented with details of the implementation of the observation strategy using JWST proposal planning tools.

The Hidden Fortress: structure and substructure of the complex strong lensing cluster SDSS J1029+2623

NASA Astrophysics Data System (ADS)

Oguri, Masamune; Schrabback, Tim; Jullo, Eric; Ota, Naomi; Kochanek, Christopher S.; Dai, Xinyu; Ofek, Eran O.; Richards, Gordon T.; Blandford, Roger D.; Falco, Emilio E.; Fohlmeister, Janine

2013-02-01

We present Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) and Wide Field Camera 3 (WFC3) observations of SDSS J1029+2623, a three-image quasar lens system produced by a foreground cluster at z = 0.584. Our strong lensing analysis reveals six additional multiply imaged galaxies in addition to the multiply imaged quasar. We confirm the complex nature of the mass distribution of the lensing cluster, with a bimodal dark matter distribution which deviates from the Chandra X-ray surface brightness distribution. The Einstein radius of the lensing cluster is estimated to be θE = 15.2 ± 0.5 arcsec for the quasar redshift of z = 2.197. We derive a radial mass distribution from the combination of strong lensing, HST/ACS weak lensing and Subaru/Suprime-cam weak lensing analysis results, finding a best-fitting virial mass of Mvir = 1.55+ 0.40- 0.35 × 1014 h- 1 M⊙ and a concentration parameter of cvir = 25.7+ 14.1- 7.5. The lensing mass estimate at the outer radius is smaller than the X-ray mass estimate by a factor of ˜2. We ascribe this large mass discrepancy to shock heating of the intracluster gas during a merger, which is also suggested by the complex mass and gas distributions and the high value of the concentration parameter. In the HST image, we also identify a probable galaxy, GX, in the vicinity of the faintest quasar image C. In strong lens models, the inclusion of GX explains the anomalous flux ratios between the quasar images. The morphology of the highly elongated quasar host galaxy is also well reproduced. The best-fitting model suggests large total magnifications of 30 for the quasar and 35 for the quasar host galaxy, and has an AB time delay consistent with the measured value.

Structure and substructure analysis of DAFT/FADA galaxy clusters in the [0.4–0.9] redshift range

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guennou, L.; et al.

2014-01-17

Context. The DAFT/FADA survey is based on the study of ~90 rich(masses found in the literature >2 x 10^14 M_⊙)and moderately distant clusters (redshifts 0.4 < z < 0.9), all withHST imaging data available. This survey has two main objectives: to constrain dark energy(DE) using weak lensing tomography on galaxy clusters and to build a database (deepmulti-band imaging allowing photometric redshift estimates, spectroscopic data, X-raydata) of rich distant clusters to study their properties.

A PRECISE CLUSTER MASS PROFILE AVERAGED FROM THE HIGHEST-QUALITY LENSING DATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Umetsu, Keiichi; Broadhurst, Tom; Zitrin, Adi

2011-09-01

We outline our methods for obtaining high-precision mass profiles, combining independent weak-lensing distortion, magnification, and strong-lensing measurements. For massive clusters, the strong- and weak-lensing regimes contribute equal logarithmic coverage of the radial profile. The utility of high-quality data is limited by the cosmic noise from large-scale structure along the line of sight. This noise is overcome when stacking clusters, as too are the effects of cluster asphericity and substructure, permitting a stringent test of theoretical models. We derive a mean radial mass profile of four similar mass clusters of high-quality Hubble Space Telescope and Subaru images, in the range Rmore » = 40-2800 kpc h {sup -1}, where the inner radial boundary is sufficiently large to avoid smoothing from miscentering effects. The stacked mass profile is detected at 58{sigma} significance over the entire radial range, with the contribution from the cosmic noise included. We show that the projected mass profile has a continuously steepening gradient out to beyond the virial radius, in remarkably good agreement with the standard Navarro-Frenk-White form predicted for the family of cold dark matter (CDM) dominated halos in gravitational equilibrium. The central slope is constrained to lie in the range, -dln {rho}/dln r = 0.89{sup +0.27}{sub -0.39}. The mean concentration is c{sub vir} = 7.68{sup +0.42}{sub -0.40} (at M{sub vir} = 1.54{sup +0.11}{sub -0.10} x 10{sup 15} M{sub sun} h {sup -1}), which is high for relaxed, high-mass clusters, but consistent with {Lambda}CDM when a sizable projection bias estimated from N-body simulations is considered. This possible tension will be more definitively explored with new cluster surveys, such as CLASH, LoCuSS, Subaru Hyper Suprime-Cam, and XXM-XXL, to construct the c{sub vir}-M{sub vir} relation over a wider mass range.« less

X-ray and optical substructures of the DAFT/FADA survey clusters

NASA Astrophysics Data System (ADS)

Guennou, L.; Durret, F.; Adami, C.; Lima Neto, G. B.

2013-04-01

We have undertaken the DAFT/FADA survey with the double aim of setting constraints on dark energy based on weak lensing tomography and of obtaining homogeneous and high quality data for a sample of 91 massive clusters in the redshift range 0.4-0.9 for which there were HST archive data. We have analysed the XMM-Newton data available for 42 of these clusters to derive their X-ray temperatures and luminosities and search for substructures. Out of these, a spatial analysis was possible for 30 clusters, but only 23 had deep enough X-ray data for a really robust analysis. This study was coupled with a dynamical analysis for the 26 clusters having at least 30 spectroscopic galaxy redshifts in the cluster range. Altogether, the X-ray sample of 23 clusters and the optical sample of 26 clusters have 14 clusters in common. We present preliminary results on the coupled X-ray and dynamical analyses of these 14 clusters.

Strong Gravitational Lensing as a Probe of Gravity, Dark-Matter and Super-Massive Black Holes

NASA Astrophysics Data System (ADS)

Koopmans, L.V.E.; Barnabe, M.; Bolton, A.; Bradac, M.; Ciotti, L.; Congdon, A.; Czoske, O.; Dye, S.; Dutton, A.; Elliasdottir, A.; Evans, E.; Fassnacht, C.D.; Jackson, N.; Keeton, C.; Lasio, J.; Moustakas, L.; Meneghetti, M.; Myers, S.; Nipoti, C.; Suyu, S.; van de Ven, G.; Vegetti, S.; Wucknitz, O.; Zhao, H.-S.

Whereas considerable effort has been afforded in understanding the properties of galaxies, a full physical picture, connecting their baryonic and dark-matter content, super-massive black holes, and (metric) theories of gravity, is still ill-defined. Strong gravitational lensing furnishes a powerful method to probe gravity in the central regions of galaxies. It can (1) provide a unique detection-channel of dark-matter substructure beyond the local galaxy group, (2) constrain dark-matter physics, complementary to direct-detection experiments, as well as metric theories of gravity, (3) probe central super-massive black holes, and (4) provide crucial insight into galaxy formation processes from the dark matter point of view, independently of the nature and state of dark matter. To seriously address the above questions, a considerable increase in the number of strong gravitational-lens systems is required. In the timeframe 2010-2020, a staged approach with radio (e.g. EVLA, e-MERLIN, LOFAR, SKA phase-I) and optical (e.g. LSST and JDEM) instruments can provide 10^(2-4) new lenses, and up to 10^(4-6) new lens systems from SKA/LSST/JDEM all-sky surveys around ~2020. Follow-up imaging of (radio) lenses is necessary with moderate ground/space-based optical-IR telescopes and with 30-50m telescopes for spectroscopy (e.g. TMT, GMT, ELT). To answer these fundamental questions through strong gravitational lensing, a strong investment in large radio and optical-IR facilities is therefore critical in the coming decade. In particular, only large-scale radio lens surveys (e.g. with SKA) provide the large numbers of high-resolution and high-fidelity images of lenses needed for SMBH and flux-ratio anomaly studies.

Weak lensing study of 16 DAFT/FADA clusters: Substructures and filaments

NASA Astrophysics Data System (ADS)

Martinet, Nicolas; Clowe, Douglas; Durret, Florence; Adami, Christophe; Acebrón, Ana; Hernandez-García, Lorena; Márquez, Isabel; Guennou, Loic; Sarron, Florian; Ulmer, Mel

2016-05-01

While our current cosmological model places galaxy clusters at the nodes of a filament network (the cosmic web), we still struggle to detect these filaments at high redshifts. We perform a weak lensing study for a sample of 16 massive, medium-high redshift (0.4

MATTER IN THE BEAM: WEAK LENSING, SUBSTRUCTURES, AND THE TEMPERATURE OF DARK MATTER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahdi, Hareth S.; Elahi, Pascal J.; Lewis, Geraint F.

2016-08-01

Warm dark matter (WDM) models offer an attractive alternative to the current cold dark matter (CDM) cosmological model. We present a novel method to differentiate between WDM and CDM cosmologies, namely, using weak lensing; this provides a unique probe as it is sensitive to all of the “matter in the beam,” not just dark matter haloes and the galaxies that reside in them, but also the diffuse material between haloes. We compare the weak lensing maps of CDM clusters to those in a WDM model corresponding to a thermally produced 0.5 keV dark matter particle. Our analysis clearly shows thatmore » the weak lensing magnification, convergence, and shear distributions can be used to distinguish between CDM and WDM models. WDM models increase the probability of weak magnifications, with the differences being significant to ≳5 σ , while leaving no significant imprint on the shear distribution. WDM clusters analyzed in this work are more homogeneous than CDM ones, and the fractional decrease in the amount of material in haloes is proportional to the average increase in the magnification. This difference arises from matter that would be bound in compact haloes in CDM being smoothly distributed over much larger volumes at lower densities in WDM. Moreover, the signature does not solely lie in the probability distribution function but in the full spatial distribution of the convergence field.« less

Optimizing weak lensing mass estimates for cluster profile uncertainty

DOE PAGES

Gruen, D.; Bernstein, G. M.; Lam, T. Y.; ...

2011-09-11

Weak lensing measurements of cluster masses are necessary for calibrating mass-observable relations (MORs) to investigate the growth of structure and the properties of dark energy. However, the measured cluster shear signal varies at fixed mass M 200m due to inherent ellipticity of background galaxies, intervening structures along the line of sight, and variations in the cluster structure due to scatter in concentrations, asphericity and substructure. We use N-body simulated halos to derive and evaluate a weak lensing circular aperture mass measurement M ap that minimizes the mass estimate variance <(M ap - M 200m) 2> in the presence of allmore » these forms of variability. Depending on halo mass and observational conditions, the resulting mass estimator improves on M ap filters optimized for circular NFW-profile clusters in the presence of uncorrelated large scale structure (LSS) about as much as the latter improve on an estimator that only minimizes the influence of shape noise. Optimizing for uncorrelated LSS while ignoring the variation of internal cluster structure puts too much weight on the profile near the cores of halos, and under some circumstances can even be worse than not accounting for LSS at all. As a result, we discuss the impact of variability in cluster structure and correlated structures on the design and performance of weak lensing surveys intended to calibrate cluster MORs.« less

The Role of Large-Scale Structure and Assembly in the Quenching of Star Formation in Cluster Galaxies at z 0.2

NASA Astrophysics Data System (ADS)

Moran, Sean; Smith, G.; Haines, C.; Egami, E.; Hardegree-Ullman, E.; Heckman, T.

2010-01-01

We present results from LoCuSS, the Local Cluster Substructure Survey, on the distribution and abundance of cluster galaxies showing signatures of recently quenched star formation, within a sample of 15 z 0.2 clusters. Combining LoCuSS' wide-field UV through NIR photometry with weak-lensing derived mass maps for these clusters, we identify passive galaxies that have undergone recent quenching via both rapid (100Myr) and slow (1Gyr) mechanisms. By studying their abundance in a statistically significant sample of z 0.2 clusters, we explore how the effectiveness of environmental quenching of star formation varies as a function of the level of cluster substructure, in addition to global cluster characteristics such as mass or X-ray luminosity and temperature, with the aim of understanding the role that pre-processing of galaxies within groups and filaments plays in the overall buildup of the morphology-density and SFR-density relations. We find that clusters with large levels of substructure indicative of recent assembly or cluster-cluster mergers host a higher fraction of galaxies with signs of recent ram-pressure stripping by the hot intra-cluster gas. In addition, we find that the fraction of post-starburst galaxies increases with cluster mass (M500), but fractions of optically-selected AGN and GALEX-defined "Green Valley" galaxies show the opposite trend, being most abundant in rather low-mass clusters. These trends suggest a picture where quenching of star formation occurs most vigorously in actively assembling structures, with comparatively little activity in the most massive structures where most of the nearby large-scale structure has already been accreted and Virialized into the main cluster body.

Probing small-scale structure in galaxies with strong gravitational lensing

NASA Astrophysics Data System (ADS)

Congdon, Arthur Benjamin

We use gravitational lensing to study the small-scale distribution of matter in galaxies. First, we examine galaxies and their dark matter halos. Roughly half of all observed four-image quasar lenses have image flux ratios that differ from the values predicted by simple lens potentials. We show that smooth departures from elliptical symmetry fail to explain anomalous radio fluxes, strengthening the case for dark matter substructure. Our results have important implications for the "missing satellites'' problem. We then consider how time delays between lensed images can be used to identify lens galaxies containing small-scale structure. We derive an analytic relation for the time delay between the close pair of images in a "fold'' lens, and perform Monte Carlo simulations to investigate the utility of time delays for probing small- scale structure in realistic lens populations. We compare our numerical predictions with systems that have measured time delays and discover two anomalous lenses. Next, we consider microlensing, where stars in the lens galaxy perturb image magnifications. This is relevant at optical wavelengths, where the size of the lensed source is comparable to the Einstein radius of a typical star. Our simulations of negative-parity images show that raising the fraction of dark matter relative to stars increases image flux variability for small sources, and decreases it for large sources. This suggests that quasar accretion disks and broad-emission-line regions may respond differently to microlensing. We also consider extended sources with a range of ellipticities, which has relevance to a population of inclined accretion disks. Depending on their orientation, more elongated sources lead to more rapid variability, which may complicate the interpretation of microlensing light curves. Finally, we consider prospects for observing strong lensing by the supermassive black hole at the center of the Milky Way, Sgr A*. Assuming a black hole on the million- solar-mass scale, we predict that the probability of observing strong lensing of a background star is roughly 56%. We also consider how lensing by Sgr A* could be used to test general relativity against alternative theories, concluding that microarcsecond resolution would make this possible.

Hubble Frontier Fields: systematic errors in strong lensing models of galaxy clusters - implications for cosmography

NASA Astrophysics Data System (ADS)

Acebron, Ana; Jullo, Eric; Limousin, Marceau; Tilquin, André; Giocoli, Carlo; Jauzac, Mathilde; Mahler, Guillaume; Richard, Johan

2017-09-01

Strong gravitational lensing by galaxy clusters is a fundamental tool to study dark matter and constrain the geometry of the Universe. Recently, the Hubble Space Telescope Frontier Fields programme has allowed a significant improvement of mass and magnification measurements but lensing models still have a residual root mean square between 0.2 arcsec and few arcseconds, not yet completely understood. Systematic errors have to be better understood and treated in order to use strong lensing clusters as reliable cosmological probes. We have analysed two simulated Hubble-Frontier-Fields-like clusters from the Hubble Frontier Fields Comparison Challenge, Ares and Hera. We use several estimators (relative bias on magnification, density profiles, ellipticity and orientation) to quantify the goodness of our reconstructions by comparing our multiple models, optimized with the parametric software lenstool, with the input models. We have quantified the impact of systematic errors arising, first, from the choice of different density profiles and configurations and, secondly, from the availability of constraints (spectroscopic or photometric redshifts, redshift ranges of the background sources) in the parametric modelling of strong lensing galaxy clusters and therefore on the retrieval of cosmological parameters. We find that substructures in the outskirts have a significant impact on the position of the multiple images, yielding tighter cosmological contours. The need for wide-field imaging around massive clusters is thus reinforced. We show that competitive cosmological constraints can be obtained also with complex multimodal clusters and that photometric redshifts improve the constraints on cosmological parameters when considering a narrow range of (spectroscopic) redshifts for the sources.

Hubble Space Telescope Observations of the Luminous IRAS Source FSC 10214+4724: A Gravitationally Lensed Infrared Quasar

NASA Technical Reports Server (NTRS)

Eisenhardt, Peter R.; Armus, Lee; Hogg, David W.; Soifer, B. T.; Neugebauer, G.; Werner, Michael W.

1996-01-01

With a redshift of 2.3, the IRAS source FSC 10214+4724 is apparently one of the most luminous objects known in the universe. We present an image of FSC 10214+4724 at 0.8 pm obtained with the Hubble Space Telescope (HST) WFPC2 Planetary Camera. The source appears as an unresolved (less then 0.06) arc 0.7 long, with significant substructure along its length. The center of curvature of the arc is located near an elliptical galaxy 1.18 to the north. An unresolved component 100 times fainter than the arc is clearly detected on the opposite side of this galaxy. The most straightforward interpretation is that FSC 10214+4724 is gravitationally lensed by the foreground elliptical galaxy, with the faint component a counter-image of the IRAS source. The brightness of the arc in the HST image is then magnified by approx. 100, and the intrinsic source diameter is approx. 0.0l (80 pc) at 0.25 microns rest wavelength. The bolometric luminosity is probably amplified by a smaller factor (approx. 30) as a result of the larger extent expected for the source in the far-infrared. A detailed lensing model is presented that reproduces the observed morphology and relative flux of the arc and counterimage and correctly predicts the position angle of the lensing galaxy. The model also predicts reasonable values for the velocity dispersion, mass, and mass-to-light ratio of the lensing galaxy for a wide range of galaxy redshifts. A redshift for the lensing galaxy of -0.9 is consistent with the measured surface brightness profile from the image, as well as with the galaxy's spectral energy distribution. The background lensed source has an intrinsic luminosity approx. 2 x 10(exp 13) L(solar mass) and remains a highly luminous quasar with an extremely large ratio of infrared to optical/ultraviolet luminosity.

Cluster galaxy dynamics and the effects of large-scale environment

NASA Astrophysics Data System (ADS)

White, Martin; Cohn, J. D.; Smit, Renske

2010-11-01

Advances in observational capabilities have ushered in a new era of multi-wavelength, multi-physics probes of galaxy clusters and ambitious surveys are compiling large samples of cluster candidates selected in different ways. We use a high-resolution N-body simulation to study how the influence of large-scale structure in and around clusters causes correlated signals in different physical probes and discuss some implications this has for multi-physics probes of clusters (e.g. richness, lensing, Compton distortion and velocity dispersion). We pay particular attention to velocity dispersions, matching galaxies to subhaloes which are explicitly tracked in the simulation. We find that not only do haloes persist as subhaloes when they fall into a larger host, but groups of subhaloes retain their identity for long periods within larger host haloes. The highly anisotropic nature of infall into massive clusters, and their triaxiality, translates into an anisotropic velocity ellipsoid: line-of-sight galaxy velocity dispersions for any individual halo show large variance depending on viewing angle. The orientation of the velocity ellipsoid is correlated with the large-scale structure, and thus velocity outliers correlate with outliers caused by projection in other probes. We quantify this orientation uncertainty and give illustrative examples. Such a large variance suggests that velocity dispersion estimators will work better in an ensemble sense than for any individual cluster, which may inform strategies for obtaining redshifts of cluster members. We similarly find that the ability of substructure indicators to find kinematic substructures is highly viewing angle dependent. While groups of subhaloes which merge with a larger host halo can retain their identity for many Gyr, they are only sporadically picked up by substructure indicators. We discuss the effects of correlated scatter on scaling relations estimated through stacking, both analytically and in the simulations, showing that the strong correlation of measures with mass and the large scatter in mass at fixed observable mitigate line-of-sight projections.

Structure and substructure analysis of DAFT/FADA galaxy clusters in the [0.4-0.9] redshift range

NASA Astrophysics Data System (ADS)

Guennou, L.; Adami, C.; Durret, F.; Lima Neto, G. B.; Ulmer, M. P.; Clowe, D.; LeBrun, V.; Martinet, N.; Allam, S.; Annis, J.; Basa, S.; Benoist, C.; Biviano, A.; Cappi, A.; Cypriano, E. S.; Gavazzi, R.; Halliday, C.; Ilbert, O.; Jullo, E.; Just, D.; Limousin, M.; Márquez, I.; Mazure, A.; Murphy, K. J.; Plana, H.; Rostagni, F.; Russeil, D.; Schirmer, M.; Slezak, E.; Tucker, D.; Zaritsky, D.; Ziegler, B.

2014-01-01

Context. The DAFT/FADA survey is based on the study of ~90 rich (masses found in the literature >2 × 1014 M⊙) and moderately distant clusters (redshifts 0.4 < z < 0.9), all with HST imaging data available. This survey has two main objectives: to constrain dark energy (DE) using weak lensing tomography on galaxy clusters and to build a database (deep multi-band imaging allowing photometric redshift estimates, spectroscopic data, X-ray data) of rich distant clusters to study their properties. Aims: We analyse the structures of all the clusters in the DAFT/FADA survey for which XMM-Newton and/or a sufficient number of galaxy redshifts in the cluster range are available, with the aim of detecting substructures and evidence for merging events. These properties are discussed in the framework of standard cold dark matter (ΛCDM) cosmology. Methods: In X-rays, we analysed the XMM-Newton data available, fit a β-model, and subtracted it to identify residuals. We used Chandra data, when available, to identify point sources. In the optical, we applied a Serna & Gerbal (SG) analysis to clusters with at least 15 spectroscopic galaxy redshifts available in the cluster range. We discuss the substructure detection efficiencies of both methods. Results: XMM-Newton data were available for 32 clusters, for which we derive the X-ray luminosity and a global X-ray temperature for 25 of them. For 23 clusters we were able to fit the X-ray emissivity with a β-model and subtract it to detect substructures in the X-ray gas. A dynamical analysis based on the SG method was applied to the clusters having at least 15 spectroscopic galaxy redshifts in the cluster range: 18 X-ray clusters and 11 clusters with no X-ray data. The choice of a minimum number of 15 redshifts implies that only major substructures will be detected. Ten substructures were detected both in X-rays and by the SG method. Most of the substructures detected both in X-rays and with the SG method are probably at their first cluster pericentre approach and are relatively recent infalls. We also find hints of a decreasing X-ray gas density profile core radius with redshift. Conclusions: The percentage of mass included in substructures was found to be roughly constant with redshift values of 5-15%, in agreement both with the general CDM framework and with the results of numerical simulations. Galaxies in substructures show the same general behaviour as regular cluster galaxies; however, in substructures, there is a deficiency of both late type and old stellar population galaxies. Late type galaxies with recent bursts of star formation seem to be missing in the substructures close to the bottom of the host cluster potential well. However, our sample would need to be increased to allow a more robust analysis. Tables 1, 2, 4 and Appendices A-C are available in electronic form at http://www.aanda.org

MC 2: Subaru and Hubble Space Telescope Weak-lensing Analysis of the Double Radio Relic Galaxy Cluster PLCK G287.0+32.9

DOE Office of Scientific and Technical Information (OSTI.GOV)

Finner, Kyle; Jee, M. James; Golovich, Nathan

The second most significant detection of the Planck Sunyaev-Zel'dovich survey, PLCK G287.0+32.9 (z = 0.385), boasts two similarly bright radio relics and a radio halo. One radio relic is locatedmore » $$\\sim 400\\,\\mathrm{kpc}$$ NW of the X-ray peak and the other $$\\sim 2.8$$ Mpc to the SE. This large difference suggests that a complex merging scenario is required. A key missing puzzle for the merging scenario reconstruction is the underlying dark matter distribution in high resolution. Here, we present a joint Subaru Telescope and Hubble Space Telescope weak-lensing analysis of the cluster. Our analysis shows that the mass distribution features four significant substructures. Of the substructures, a primary cluster of mass $${M}_{200{\\rm{c}}}={1.59}_{-0.22}^{+0.25}\\times {10}^{15}\\ {h}_{70}^{-1}\\ {M}_{\\odot }$$ dominates the weak-lensing signal. This cluster is likely to be undergoing a merger with one (or more) subcluster whose mass is approximately a factor of 10 lower. One candidate is the subcluster of mass $${M}_{200{\\rm{c}}}={1.16}_{-0.13}^{+0.15}\\times {10}^{14}\\ {h}_{70}^{-1}\\ {M}_{\\odot }$$ located $$\\sim 400\\,\\mathrm{kpc}$$ to the SE. The location of this subcluster suggests that its interaction with the primary cluster could be the source of the NW radio relic. Another subcluster is detected $$\\sim 2$$ Mpc to the SE of the X-ray peak with mass $${M}_{200{\\rm{c}}}={1.68}_{-0.20}^{+0.22}\\times {10}^{14}\\ {h}_{70}^{-1}\\ {M}_{\\odot }$$. This SE subcluster is in the vicinity of the SE radio relic and may have created the SE radio relic during a past merger with the primary cluster. The fourth subcluster, $${M}_{200{\\rm{c}}}={1.87}_{-0.22}^{+0.24}\\times {10}^{14}\\ {h}_{70}^{-1}\\ {M}_{\\odot }$$, is NW of the X-ray peak and beyond the NW radio relic.« less

MC 2: Subaru and Hubble Space Telescope Weak-lensing Analysis of the Double Radio Relic Galaxy Cluster PLCK G287.0+32.9

DOE PAGES

Finner, Kyle; Jee, M. James; Golovich, Nathan; ...

2017-12-11

The second most significant detection of the Planck Sunyaev-Zel'dovich survey, PLCK G287.0+32.9 (z = 0.385), boasts two similarly bright radio relics and a radio halo. One radio relic is locatedmore » $$\\sim 400\\,\\mathrm{kpc}$$ NW of the X-ray peak and the other $$\\sim 2.8$$ Mpc to the SE. This large difference suggests that a complex merging scenario is required. A key missing puzzle for the merging scenario reconstruction is the underlying dark matter distribution in high resolution. Here, we present a joint Subaru Telescope and Hubble Space Telescope weak-lensing analysis of the cluster. Our analysis shows that the mass distribution features four significant substructures. Of the substructures, a primary cluster of mass $${M}_{200{\\rm{c}}}={1.59}_{-0.22}^{+0.25}\\times {10}^{15}\\ {h}_{70}^{-1}\\ {M}_{\\odot }$$ dominates the weak-lensing signal. This cluster is likely to be undergoing a merger with one (or more) subcluster whose mass is approximately a factor of 10 lower. One candidate is the subcluster of mass $${M}_{200{\\rm{c}}}={1.16}_{-0.13}^{+0.15}\\times {10}^{14}\\ {h}_{70}^{-1}\\ {M}_{\\odot }$$ located $$\\sim 400\\,\\mathrm{kpc}$$ to the SE. The location of this subcluster suggests that its interaction with the primary cluster could be the source of the NW radio relic. Another subcluster is detected $$\\sim 2$$ Mpc to the SE of the X-ray peak with mass $${M}_{200{\\rm{c}}}={1.68}_{-0.20}^{+0.22}\\times {10}^{14}\\ {h}_{70}^{-1}\\ {M}_{\\odot }$$. This SE subcluster is in the vicinity of the SE radio relic and may have created the SE radio relic during a past merger with the primary cluster. The fourth subcluster, $${M}_{200{\\rm{c}}}={1.87}_{-0.22}^{+0.24}\\times {10}^{14}\\ {h}_{70}^{-1}\\ {M}_{\\odot }$$, is NW of the X-ray peak and beyond the NW radio relic.« less

The SPT+Herschel+ALMA+Spitzer Legacy Survey: The stellar content of high redshift strongly lensed systems

NASA Astrophysics Data System (ADS)

Vieira, Joaquin; Ashby, Matt; Carlstrom, John; Chapman, Scott; DeBreuck, Carlos; Fassnacht, Chris; Gonzalez, Anthony; Phadke, Kedar; Marrone, Dan; Malkan, Matt; Reuter, Cassie; Rotermund, Kaja; Spilker, Justin; Weiss, Axel

2018-05-01

The South Pole Telescope (SPT) has systematically identified 90 high-redshift strongly gravitationally lensed submillimeter galaxies (SMGs) in a 2500 square-degree cosmological survey of the millimeter (mm) sky. These sources are selected by their extreme mm flux, which is largely independent of redshift and lensing configuration. We are undertaking a comprehensive and systematic followup campaign to use these "cosmic magnifying glasses" to study the infrared background in unprecedented detail, inform the condition of the interstellar medium in starburst galaxies at high redshift, and place limits on dark matter substructure. Here we ask for 115.4 hours of deep Spitzer/IRAC imaging to complete our survey of 90 systems to a uniform depth of 30min integrations at 3.6um and 60min at 4.5um. In our sample of 90 systems, 16 have already been fully observed, 30 have been partially observed, and 44 have not been observed at all. Our immediate goals are to: 1) constrain the specific star formation rates of the background high-redshift submillimeter galaxies by combining these Spitzer observations with our APEX, Herschel, and ALMA data, 2) robustly determine the stellar masses and mass-to-light ratios of all the foreground lensing galaxies in the sample by combining these observations with our VLT and Gemini data, the Dark Energy Survey, and ALMA; and 3) provide complete, deep, and uniform NIR coverage of our entire sample of lensed systems to characterize the environments of high redshift SMGs, maximize the discovery potential for additional spectacular and rare sources, and prepare for JWST. This program will provide the cornerstone data set for two PhD theses: Kedar Phadke at Illinois will lead the analysis of stellar masses for the background SMGs, and Kaja Rotermund at Dalhousie will lead the analysis of stellar masses for the foreground lenses.

X-ray aspects of the DAFT/FADA clusters

NASA Astrophysics Data System (ADS)

Guennou, L.; Durret, F.; Lima Neto, G. B.; Adami, C.

2012-12-01

We have undertaken the DAFT/FADA survey with the aim of applying constraints on dark energy based on weak lensing tomography as well as obtaining homogeneous and high quality data for a sample of 91 massive clusters in the redshift range [0.4,0.9] for which there are HST archive data. We have analysed the XMM-Newton data available for 42 of these clusters to derive their X-ray temperatures and luminosities and search for substructures. This study was coupled with a dynamical analysis for the 26 clusters having at least 30 spectroscopic galaxy redshifts in the cluster range. We present preliminary results on the coupled X-ray and dynamical analyses of these clusters.

The Double Galaxy Cluster A2465. III. X-Ray and Weak-lensing Observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wegner, Gary A.; Umetsu, Keiichi; Molnar, Sandor M.

We report Chandra X-ray observations and optical weak-lensing measurements from Subaru/Suprime-Cam images of the double galaxy cluster A2465 ( z = 0.245). The X-ray brightness data are fit to a β model to obtain the radial gas density profiles of the northeast (NE) and southwest (SW) subcomponents, which are seen to differ in structure. We determine core radii, central temperatures, the gas masses within r {sub 500c}, and the total masses for the broader NE and sharper SW components assuming hydrostatic equilibrium. There is no large X-ray excess between the two components. The central entropy of the NE subcluster ismore » about two times higher than the SW. Along with its structural properties and an apparent radio halo that is a sign of a merger, this suggests that the NE component has undergone merging on its own. The weak-lensing analysis gives virial masses for each substructure, which compare well with earlier dynamical results. The derived outer mass contours of the SW sub-component from weak lensing are more irregular and extended than those of the NE. Although there is a weak enhancement and small offsets between X-ray gas and mass centers from weak lensing, the lack of large amounts of gas between the two subclusters indicates that A2465 is in a pre-merger state. We discuss star formation enhancement in this system resulting from its dynamics and shock-induced star formation scenarios. A dynamical model that is consistent with the observed cluster data, based on the FLASH program and the radial infall model, is constructed, where the subclusters currently separated by ∼1.2 Mpc are approaching each other at ∼2000 km s{sup −1} and will meet in ∼0.4 Gyr.« less

The Double Galaxy Cluster A2465. III. X-Ray and Weak-lensing Observations

NASA Astrophysics Data System (ADS)

Wegner, Gary A.; Umetsu, Keiichi; Molnar, Sandor M.; Nonino, Mario; Medezinski, Elinor; Andrade-Santos, Felipe; Bogdan, Akos; Lovisari, Lorenzo; Forman, William R.; Jones, Christine

2017-07-01

We report Chandra X-ray observations and optical weak-lensing measurements from Subaru/Suprime-Cam images of the double galaxy cluster A2465 (z = 0.245). The X-ray brightness data are fit to a β model to obtain the radial gas density profiles of the northeast (NE) and southwest (SW) subcomponents, which are seen to differ in structure. We determine core radii, central temperatures, the gas masses within r 500c, and the total masses for the broader NE and sharper SW components assuming hydrostatic equilibrium. There is no large X-ray excess between the two components. The central entropy of the NE subcluster is about two times higher than the SW. Along with its structural properties and an apparent radio halo that is a sign of a merger, this suggests that the NE component has undergone merging on its own. The weak-lensing analysis gives virial masses for each substructure, which compare well with earlier dynamical results. The derived outer mass contours of the SW sub-component from weak lensing are more irregular and extended than those of the NE. Although there is a weak enhancement and small offsets between X-ray gas and mass centers from weak lensing, the lack of large amounts of gas between the two subclusters indicates that A2465 is in a pre-merger state. We discuss star formation enhancement in this system resulting from its dynamics and shock-induced star formation scenarios. A dynamical model that is consistent with the observed cluster data, based on the FLASH program and the radial infall model, is constructed, where the subclusters currently separated by ˜1.2 Mpc are approaching each other at ˜2000 km s-1 and will meet in ˜0.4 Gyr. Based in part on data collected at the Subaru Telescope, which is operated by the National Astronomical Society of Japan.

LoCuSS: weak-lensing mass calibration of galaxy clusters

NASA Astrophysics Data System (ADS)

Okabe, Nobuhiro; Smith, Graham P.

2016-10-01

We present weak-lensing mass measurements of 50 X-ray luminous galaxy clusters at 0.15 ≤ z ≤ 0.3, based on uniform high-quality observations with Suprime-Cam mounted on the 8.2-m Subaru telescope. We pay close attention to possible systematic biases, aiming to control them at the ≲4 per cent level. The dominant source of systematic bias in weak-lensing measurements of the mass of individual galaxy clusters is contamination of background galaxy catalogues by faint cluster and foreground galaxies. We extend our conservative method for selecting background galaxies with (V - I') colours redder than the red sequence of cluster members to use a colour-cut that depends on cluster-centric radius. This allows us to define background galaxy samples that suffer ≤1 per cent contamination, and comprise 13 galaxies per square arcminute. Thanks to the purity of our background galaxy catalogue, the largest systematic that we identify in our analysis is a shape measurement bias of 3 per cent, that we measure using simulations that probe weak shears up to g = 0.3. Our individual cluster mass and concentration measurements are in excellent agreement with predictions of the mass-concentration relation. Equally, our stacked shear profile is in excellent agreement with the Navarro Frenk and White profile. Our new Local Cluster Substructure Survey mass measurements are consistent with the Canadian Cluster Cosmology Project and Cluster Lensing And Supernova Survey with Hubble surveys, and in tension with the Weighing the Giants at ˜1σ-2σ significance. Overall, the consensus at z ≤ 0.3 that is emerging from these complementary surveys represents important progress for cluster mass calibration, and augurs well for cluster cosmology.

NASTRAN multipartitioning and one-shot substructuring

NASA Technical Reports Server (NTRS)

Levy, A.

1973-01-01

For intermediate size problems where all the data is accessible, the present method of substructuring in three separate phases (for static analysis) is unneccessarily cumbersome. The versatility of NASTRAN's DMAP and internal logic lends itself to finding a practical alternative to these procedures whereby self-contained special-purpose ALTER packages can be written to be run in one pass. Two examples are presented here under the titles of multipartitioning and one-shot substructuring. The flow of multipartitioning resembles that of the present three-phase substructuring. The basic effect is to partition the structure into substructures and operate on each substructure separately. This can be used to reduce the bandwidth of a given problem as well as to store information which will allow a change to be made in one of the substructures in a later run. This latter procedure is carried out in a second program titled one-shot substructuring.

Strong-lensing analysis of A2744 with MUSE and Hubble Frontier Fields images

NASA Astrophysics Data System (ADS)

Mahler, G.; Richard, J.; Clément, B.; Lagattuta, D.; Schmidt, K.; Patrício, V.; Soucail, G.; Bacon, R.; Pello, R.; Bouwens, R.; Maseda, M.; Martinez, J.; Carollo, M.; Inami, H.; Leclercq, F.; Wisotzki, L.

2018-01-01

We present an analysis of Multi Unit Spectroscopic Explorer (MUSE) observations obtained on the massive Frontier Fields (FFs) cluster A2744. This new data set covers the entire multiply imaged region around the cluster core. The combined catalogue consists of 514 spectroscopic redshifts (with 414 new identifications). We use this redshift information to perform a strong-lensing analysis revising multiple images previously found in the deep FF images, and add three new MUSE-detected multiply imaged systems with no obvious Hubble Space Telescope counterpart. The combined strong-lensing constraints include a total of 60 systems producing 188 images altogether, out of which 29 systems and 83 images are spectroscopically confirmed, making A2744 one of the most well-constrained clusters to date. Thanks to the large amount of spectroscopic redshifts, we model the influence of substructures at larger radii, using a parametrization including two cluster-scale components in the cluster core and several group scale in the outskirts. The resulting model accurately reproduces all the spectroscopic multiple systems, reaching an rms of 0.67 arcsec in the image plane. The large number of MUSE spectroscopic redshifts gives us a robust model, which we estimate reduces the systematic uncertainty on the 2D mass distribution by up to ∼2.5 times the statistical uncertainty in the cluster core. In addition, from a combination of the parametrization and the set of constraints, we estimate the relative systematic uncertainty to be up to 9 per cent at 200 kpc.

Multipole models of four-image gravitational lenses with anomalous flux ratios

NASA Astrophysics Data System (ADS)

Congdon, Arthur B.; Keeton, Charles R.

2005-12-01

It has been known for over a decade that many four-image gravitational lenses exhibit anomalous radio flux ratios. These anomalies can be explained by adding a clumpy cold dark matter (CDM) component to the background galactic potential of the lens. As an alternative, Evans & Witt (2003) recently suggested that smooth multipole perturbations provide a reasonable alternative to CDM substructure in some but not all cases. We generalize their method in two ways so as to determine whether multipole models can explain highly anomalous systems. We carry the multipole expansion to higher order, and also include external tidal shear as a free parameter. Fitting for the shear proves crucial to finding a physical (positive-definite density) model. For B1422+231, working to order kmax= 5 (and including shear) yields a model that is physical but implausible. Going to higher order (kmax>~ 9) reduces global departures from ellipticity, but at the cost of introducing small-scale wiggles in proximity to the bright images. These localized undulations are more pronounced in B2045+265, where kmax~ 17 multipoles are required to smooth out large-scale deviations from elliptical symmetry. Such modes surely cannot be taken at face value; they must indicate that the models are trying to reproduce some other sort of structure. Our formalism naturally finds models that fit the data exactly, but we use B0712+472 to show that measurement uncertainties have little effect on our results. Finally, we consider the system B1933+503, where two sources are lensed by the same foreground galaxy. The additional constraints provided by the images of the second source render the multipole model unphysical. We conclude that external shear must be taken into account to obtain plausible models, and that a purely smooth angular structure for the lens galaxy does not provide a viable alternative to the prevailing CDM clump hypothesis.

The Cosmological Dependence of Galaxy Cluster Morphologies

NASA Astrophysics Data System (ADS)

Crone, Mary Margaret

1995-01-01

Measuring the density of the universe has been a fundamental problem in cosmology ever since the "Big Bang" model was developed over sixty years ago. In this simple and successful model, the age and eventual fate of the universe are determined by its density, its rate of expansion, and the value of a universal "cosmological constant". Analytic models suggest that many properties of galaxy clusters are sensitive to cosmological parameters. In this thesis, I use N-body simulations to examine cluster density profiles, abundances, and degree of subclustering to test the feasibility of using them as cosmological tests. The dependence on both cosmology and initial density field is examined, using a grid of cosmologies and scale-free initial power spectra P(k)~ k n. Einstein-deSitter ( Omegao=1), open ( Omegao=0.2 and 0.1) and flat, low density (Omegao=0.2, lambdao=0.8) models are studied, with initial spectral indices n=-2, -1 and 0. Of particular interest are the results for cluster profiles and substructure. The average density profiles are well fit by a power law p(r)~ r ^{-alpha} for radii where the local density contrast is between 100 and 3000. There is a clear trend toward steeper slopes with both increasing n and decreasing Omegao, with profile slopes in the open models consistently higher than Omega=1 values for the range of n examined. The amount of substructure in each model is quantified and explained in terms of cluster merger histories and the behavior of substructure statistics. The statistic which best distinguishes models is a very simple measure of deviations from symmetry in the projected mass distribution --the "Center-of-Mass Shift" as a function of overdensity. Some statistics which are quite sensitive to substructure perform relatively poorly as cosmological indicators. Density profiles and the Center-of-Mass test are both well-suited for comparison with weak lensing data and galaxy distributions. Such data are currently being collected and should be available within the next few years. At that time the predictions described here can be used to set useful cosmological constraints.

Effect of load eccentricity and substructure deformation on ultimate strength of shuttle orbiter thermal protection system

NASA Technical Reports Server (NTRS)

Sawyer, J. W.

1981-01-01

The effect of load eccentricity and substructure deformation on the ultimate strength and stress displacement properties of the shuttle orbiter thermal protection system (TPS) was determined. The LI-900 Reusable Surface Insulation (RSI) tiles mounted on the .41 cm thick Strain Isolator Pad (SIP) were investigated. Substructure deformations reduce the ultimate strength of the SIP/tile TPS and increase the scatter in the ultimate strength data. Substructure deformations that occur unsymmetric to the tile can cause the tile to rotate when subjected to a uniform applied load. Load eccentricity reduces SIP/tile TPS ultimate strength and causes tile rotation.

Effect of temperature on the formation of creep substructure in sodium chloride single crystals

NASA Technical Reports Server (NTRS)

Raj, Sai V.; Pharr, George M.

1992-01-01

The effect of temperature on the substructure morphology and the cell and subgrain size was investigated experimentally in NaCl single crystals under creep in the temperature range 573-873 K. It is found that the effect of temperature on the cell and subgrain sizes is weak in comparison with the effect of stress. However, there was a qualitative change in the substructure morphology with temperature, with the cells and subgrains better defined at higher temperatures. The volume fraction of the cell boundaries decreased with increasing temperature, thereby indicating a refinement of the microstructure at higher temperatures.

LoCuSS: comparison of observed X-ray and lensing galaxy cluster scaling relations with simulations

NASA Astrophysics Data System (ADS)

Zhang, Y.-Y.; Finoguenov, A.; Böhringer, H.; Kneib, J.-P.; Smith, G. P.; Kneissl, R.; Okabe, N.; Dahle, H.

2008-05-01

The Local Cluster Substructure Survey (LoCuSS, Smith et al.) is a systematic multi-wavelength survey of more than 100 X-ray luminous galaxy clusters in the redshift range 0.14-0.3 selected from the ROSAT All Sky Survey. We used data on 37 LoCuSS clusters from the XMM-Newton archive to investigate the global scaling relations of galaxy clusters. The scaling relations based solely on the X-ray data (S-T, S-Y_X, P-Y_X, M-T, M-Y_X, M-M_gas, M_gas-T, L-T, L-Y_X, and L-M) obey empirical self-similarity and reveal no additional evolution beyond the large-scale structure growth. They also reveal up to 17 per cent segregation between all 37 clusters and non-cool core clusters. Weak lensing mass measurements are also available in the literature for 19 of the clusters with XMM-Newton data. The average of the weak lensing mass to X-ray based mass ratio is 1.09± 0.08, setting the limit of the non-thermal pressure support to 9 ± 8 per cent. The mean of the weak lensing mass to X-ray based mass ratio of these clusters is ~1, indicating good agreement between X-ray and weak lensing masses for most clusters, although with 31-51 per cent scatter. The scatter in the mass-observable relations (M-Y_X, M-M_gas, and M-T) is smaller using X-ray based masses than using weak lensing masses by a factor of 2. With the scaled radius defined by the YX profile - r500 Y_X,X, r500YX,wl, and r500Y_X,si, we obtain lower scatter in the weak lensing mass based mass-observable relations, which means the origin of the scatter is M^wl and MX instead of Y_X. The normalization of the M-YX relation using X-ray mass estimates is lower than the one from simulations by up to 18-24 per cent at 3σ significance. This agrees with the M-YX relation based on weak lensing masses, the normalization of the latter being ~20 per cent lower than the one from simulations at ~2σ significance. This difference between observations and simulations is also indicated in the M-M_gas and M-T relations. Despite the large scatter in the comparison of X-ray to lensing, the agreement between these two completely independent observational methods is an important step towards controlling astrophysical and measurement systematics in cosmological scaling relations. This work is based on observations made with the XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA member states and the USA (NASA). Appendices A-C are only available in electronic form at http://www.aanda.org

A simple prescription for simulating and characterizing gravitational arcs

NASA Astrophysics Data System (ADS)

Furlanetto, C.; Santiago, B. X.; Makler, M.; de Bom, C.; Brandt, C. H.; Neto, A. F.; Ferreira, P. C.; da Costa, L. N.; Maia, M. A. G.

2013-01-01

Simple models of gravitational arcs are crucial for simulating large samples of these objects with full control of the input parameters. These models also provide approximate and automated estimates of the shape and structure of the arcs, which are necessary for detecting and characterizing these objects on massive wide-area imaging surveys. We here present and explore the ArcEllipse, a simple prescription for creating objects with a shape similar to gravitational arcs. We also present PaintArcs, which is a code that couples this geometrical form with a brightness distribution and adds the resulting object to images. Finally, we introduce ArcFitting, which is a tool that fits ArcEllipses to images of real gravitational arcs. We validate this fitting technique using simulated arcs and apply it to CFHTLS and HST images of tangential arcs around clusters of galaxies. Our simple ArcEllipse model for the arc, associated to a Sérsic profile for the source, recovers the total signal in real images typically within 10%-30%. The ArcEllipse+Sérsic models also automatically recover visual estimates of length-to-width ratios of real arcs. Residual maps between data and model images reveal the incidence of arc substructure. They may thus be used as a diagnostic for arcs formed by the merging of multiple images. The incidence of these substructures is the main factor that prevents ArcEllipse models from accurately describing real lensed systems.

Effects of modal truncation and condensation methods on the Frequency Response Function of a stage reducer connected by rigid coupling to a planetary gear system

NASA Astrophysics Data System (ADS)

Bouslema, Marwa; Frikha, Ahmed; Abdennadhar, Moez; Fakhfakh, Tahar; Nasri, Rachid; Haddar, Mohamed

2017-12-01

The present paper is aimed at the application of a substructure methodology, based on the Frequency Response Function (FRF) simulation technique, to analyze the vibration of a stage reducer connected by a rigid coupling to a planetary gear system. The computation of the vibration response was achieved using the FRF-based substructuring method. First of all, the two subsystems were analyzed separately and their FRF were obtained. Then the coupled model was analyzed indirectly using the substructuring technique. A comparison between the full system response and the coupled model response using the FRF substructuring was investigated to validate the coupling method. Furthermore, a parametric study of the effect of the shaft coupling stiffness on the FRF was discussed and the effects of modal truncation and condensation methods on the FRF of subsystems were analyzed.

Exploiting parallel computing with limited program changes using a network of microcomputers

NASA Technical Reports Server (NTRS)

Rogers, J. L., Jr.; Sobieszczanski-Sobieski, J.

1985-01-01

Network computing and multiprocessor computers are two discernible trends in parallel processing. The computational behavior of an iterative distributed process in which some subtasks are completed later than others because of an imbalance in computational requirements is of significant interest. The effects of asynchronus processing was studied. A small existing program was converted to perform finite element analysis by distributing substructure analysis over a network of four Apple IIe microcomputers connected to a shared disk, simulating a parallel computer. The substructure analysis uses an iterative, fully stressed, structural resizing procedure. A framework of beams divided into three substructures is used as the finite element model. The effects of asynchronous processing on the convergence of the design variables are determined by not resizing particular substructures on various iterations.

VLT adaptive optics search for luminous substructures in the lens galaxy towards SDSS J0924+0219

NASA Astrophysics Data System (ADS)

Faure, C.; Sluse, D.; Cantale, N.; Tewes, M.; Courbin, F.; Durrer, P.; Meylan, G.

2011-12-01

The anomalous flux ratios between quasar images are suspected of being caused by substructures in lens galaxies. We present new deep and high-resolution H and Ks imaging of the strongly lensed quasar SDSS J0924+0219 obtained using the ESO VLT with adaptive optics and the laser guide star system. SDSS J0924+0219 is particularly interesting because the observed flux ratio between the quasar images vastly disagree with the predictions from smooth mass models. With our adaptive optics observations we find a luminous object, Object L, located ~0.3'' to the north of the lens galaxy, but we show that it cannot be responsible for the anomalous flux ratios. Object L as well as a luminous extension of the lens galaxy to the south are seen in the archival HST/ACS image in the F814W filter. This suggests that Object L is part of a bar in the lens galaxy, as also supported by the presence of a significant disk component in the light profile of the lens galaxy. Finally, we find no evidence of any other luminous substructure that may explain the quasar images flux ratios. However, owing to the persistence of the flux ratio anomaly over time (~7 years), a combination of microlensing and millilensing is the favorite explanation for the observations. Based on observations obtained with the ESO VLT at Paranal observatory (Prog ID 084.A-0762(A); PI: Meylan). Also based in part on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with the CASTLES (Cfa-Arizona Space Telescope LEns Survey) survey (ID: 9744, PI: C. S. Kochanek).

Recombination algorithms and jet substructure: Pruning as a tool for heavy particle searches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ellis, Stephen D.; Vermilion, Christopher K.; Walsh, Jonathan R.

2010-05-01

We discuss jet substructure in recombination algorithms for QCD jets and single jets from heavy particle decays. We demonstrate that the jet algorithm can introduce significant systematic effects into the substructure. By characterizing these systematic effects and the substructure from QCD, splash-in, and heavy particle decays, we identify a technique, pruning, to better identify heavy particle decays into single jets and distinguish them from QCD jets. Pruning removes protojets typical of soft, wide-angle radiation, improves the mass resolution of jets reconstructing heavy particle decays, and decreases the QCD background to these decays. We show that pruning provides significant improvements overmore » unpruned jets in identifying top quarks and W bosons and separating them from a QCD background, and may be useful in a search for heavy particles.« less

Merging Galaxy Clusters: A Case Study of ZwCl 2341.1+0000 and the Development of a New Forward Modeled Lensing Technique

NASA Astrophysics Data System (ADS)

Benson, Bryant Joseph

Context: Galaxy clusters are the most massive gravitationally bound structures in the universe and are formed through the process of hierarchical clustering, in which smaller systems undergo a series of mergers to form ever larger clusters. Because of the masses involved, mergers between these giants provide a unique laboratory for observing many interesting astrophysical processes. These merging systems also act as large dark matter colliders, because the dark matter halos of the clusters involved pass through each other during of the merger. This offers us a means to observe if dark matter-dark matter collisions result in momentum exchange beyond what occurs from gravity alone. Such observations can help us to unravel some of the mysteries behind dark matter, such as does it interact with itself through mechanisms beyond gravity, and how strong are those interactions. Answers to questions like these are what will eventually allow us to discover what dark matter really is. However, the extremely long time scales for these mergers (˜several billion years) make each observation a single snapshot in the long merger history, and we must infer many of the details necessary for understanding the full merger process. Furthermore, current weak lensing analyses lack the precision required to detect a signal from self-interacting dark matter. Uncertain weak lensing mass and position estimates also yield large uncertainties in the dynamical reconstruction of the merger scenarios. Need: In order to better model the dynamics of merging galaxy cluster systems, and to potentially measure any signal from self-interacting dark matter, we need to obtain more precise measurements on the masses and positions of the dark matter halos involved. Gravitational lensing offers a robust method for mapping the mass in these clusters because it directly measures the gravitational field, and does not depend on the dynamical state of the system that has been disturbed in the merger process. Of the lensing methods, weak gravitational lensing is the only way that we can probe a wide field and measure the total mass of the cluster. However, the precision of conventional weak lensing techniques is currently limited by shape noise (uncertainty in the shear due to the dispersion in the intrinsic shapes and orientations of unlensed galaxies). A possible avenue forward is to eliminate shape noise as a source of uncertainty in shear measurements via a technique to be described below. This would eliminate the largest source of uncertainty in weak lensing analyses, and enable us to obtain mass and position estimates of dark matter halos with a much higher level of precision. Task: In this dissertation we perform statistical clustering, conventional weak lensing analyses, and dynamical reconstruction on the merging galaxy cluster system ZwCl 2341.1+0000 in order to test the capabilities of the dynamical modeling on a complex, multiple merger. We use targeted optical spectroscopy to identify cluster member galaxies, which we then use to model the galaxy substructures. We also obtain a dynamical mass estimate using the galaxy velocity dispersions, and perform weak lensing analyses in the forms of aperture densitometry to place an upper bound on the total cluster mass, and multiple NFW profile halo fitting to approximate the masses and positions of the individual dark matter halos present in the merger. The masses, positions, and line of sight velocities of those clusters are then used to constrain the parameters describing the best fit merger scenario, with radio relic positions and polarization used to further tighten those constraints. We also develop a new method for obtaining weak lensing data from individual source galaxies in the form of shear measurements that are independent of shape noise, and direct measurements of the convergence. We accomplish this by simultaneously modeling the pre-lensing velocity and intensity profiles of a lensed, rotating disk galaxy, and the lensing transform required to distort those into the lensed profiles we observe. We test this method with a host of idealized simulations to characterize its capabilities in a best-case scenario and forecast the possible improvements it can bring to the precision of weak lensing analyses on galaxy clusters. (Abstract shortened by ProQuest.).

Procedures, cost and effectiveness for deteriorated bridge substructure repair.

DOT National Transportation Integrated Search

2013-03-01

Deterioration of bridge substructures has been a serious concern throughout Wisconsin. Concrete, steel and : timber components all require distinct repair methods which not only address the true cause of the deterioration, : but also protect the comp...

Singular behavior of jet substructure observables

DOE PAGES

Larkoski, Andrew J.; Moult, Ian

2016-01-20

Jet substructure observables play a central role at the Large Hadron Collider for identifying the boosted hadronic decay products of electroweak scale resonances. The complete description of these observables requires understanding both the limit in which hard substructure is resolved, as well as the limit of a jet with a single hard core. In this paper we study in detail the perturbative structure of two prominent jet substructure observables, N-subjettiness and the energy correlation functions, as measured on background QCD jets. In particular, we focus on the distinction between the limits in which two-prong structure is resolved or unresolved. Dependingmore » on the choice of subjet axes, we demonstrate that at fixed order, N-subjettiness can manifest myriad behaviors in the unresolved region: smooth tails, end-point singularities, or singularities in the physical region. The energy correlation functions, by contrast, only have non-singular perturbative tails extending to the end point. We discuss the effect of hadronization on the various observables with Monte Carlo simulation and demonstrate that the modeling of these effects with non-perturbative shape functions is highly dependent on the N-subjettiness axes definitions. Lastly, our study illustrates those regions of phase space that must be controlled for high-precision jet substructure calculations, and emphasizes how such calculations can be facilitated by designing substructure observables with simple singular structures.« less

The Protective Effect of Brown-, Gray-, and Blue-Tinted Lenses against Blue LED Light-Induced Cell Death in A2E-Laden Human Retinal Pigment Epithelial Cells.

PubMed

Park, Sang-Il; Jang, Young Pyo

2017-01-01

A2E-laden ARPE-19 cells were exposed to a blue light to induce cytotoxicity, in order to investigate the protective effects of various tinted ophthalmic lenses against photo-induced cytotoxicity in human retinal pigment epithelial (RPE) cells laden with A2E, known to be among the etiologies of age-related macular degeneration (AMD). Different-colored tinted lenses with varying levels of tint and different filtering characteristics, such as polarized, blue-cut, and photochromatic lenses, were placed over the cells, and the protective efficacies thereof were evaluated by lactate dehydrogenase assay. When tinted lenses were placed over ARPE-19 cells, there were different reductions in cytotoxicity according to the colors and tint levels. The level of protection afforded by brown-tinted lenses was 6.9, 36.1, and 49% with a tint level of 15, 50, and 80%, respectively. For gray-tinted lenses, the protective effect was 16.3, 35, and 43.4% for the corresponding degree of tint, respectively. In the case of blue-tinted lenses, a protective effect of 20% was observed with 80% tinted lenses, but 15 and 50% tinted lenses provided no significant protection. In addition, photochromic lenses showed a protective effect but blue-cut lenses and polarized lenses provided no significant protection. Tinted lenses significantly reduced cytotoxicity in RPE cells irradiated with blue light. The protection was more efficient in lenses with a brown or gray tint than in blue-tinted lenses. Tinted glasses may provide significant protection against potential blue-light-induced photochemical and photo-oxidative damage in RPE cells. © 2016 S. Karger AG, Basel.

Cluster bulleticity

NASA Astrophysics Data System (ADS)

Massey, Richard; Kitching, Thomas; Nagai, Daisuke

2011-05-01

The unique properties of dark matter are revealed during collisions between clusters of galaxies, such as the bullet cluster (1E 0657-56) and baby bullet (MACS J0025-12). These systems provide evidence for an additional, invisible mass in the separation between the distributions of their total mass, measured via gravitational lensing, and their ordinary 'baryonic' matter, measured via its X-ray emission. Unfortunately, the information available from these systems is limited by their rarity. Constraints on the properties of dark matter, such as its interaction cross-section, are therefore restricted by uncertainties in the individual systems' impact velocity, impact parameter and orientation with respect to the line of sight. Here we develop a complementary, statistical measurement in which every piece of substructure falling into every massive cluster is treated as a bullet. We define 'bulleticity' as the mean separation between dark matter and ordinary matter, and we measure the signal in hydrodynamical simulations. The phase space of substructure orbits also exhibits symmetries that provide an equivalent control test. Any detection of bulleticity in real data would indicate a difference in the interaction cross-sections of baryonic and dark matter that may rule out hypotheses of non-particulate dark matter that are otherwise able to model individual systems. A subsequent measurement of bulleticity could constrain the dark matter cross-section. Even with conservative estimates, the existing Hubble Space Telescope archive should yield an independent constraint tighter than that from the bullet cluster. This technique is then trivially extendable to and benefits enormously from larger, future surveys.

Gravitational detection of a low-mass dark satellite galaxy at cosmological distance.

PubMed

Vegetti, S; Lagattuta, D J; McKean, J P; Auger, M W; Fassnacht, C D; Koopmans, L V E

2012-01-18

The mass function of dwarf satellite galaxies that are observed around Local Group galaxies differs substantially from simulations based on cold dark matter: the simulations predict many more dwarf galaxies than are seen. The Local Group, however, may be anomalous in this regard. A massive dark satellite in an early-type lens galaxy at a redshift of 0.222 was recently found using a method based on gravitational lensing, suggesting that the mass fraction contained in substructure could be higher than is predicted from simulations. The lack of very low-mass detections, however, prohibited any constraint on their mass function. Here we report the presence of a (1.9 ± 0.1) × 10(8) M dark satellite galaxy in the Einstein ring system JVAS B1938+666 (ref. 11) at a redshift of 0.881, where M denotes the solar mass. This satellite galaxy has a mass similar to that of the Sagittarius galaxy, which is a satellite of the Milky Way. We determine the logarithmic slope of the mass function for substructure beyond the local Universe to be 1.1(+0.6)(-0.4), with an average mass fraction of 3.3(+3.6)(-1.8) per cent, by combining data on both of these recently discovered galaxies. Our results are consistent with the predictions from cold dark matter simulations at the 95 per cent confidence level, and therefore agree with the view that galaxies formed hierarchically in a Universe composed of cold dark matter.

Experimental modal substructuring to couple and uncouple substructures with flexible fixtures and multi-point connections

NASA Astrophysics Data System (ADS)

Allen, Matthew S.; Mayes, Randall L.; Bergman, Elizabeth J.

2010-11-01

Modal substructuring or component mode synthesis (CMS) has been standard practice for many decades in the analytical realm, yet a number of significant difficulties have been encountered when attempting to combine experimentally derived modal models with analytical ones or when predicting the effect of structural modifications using experimental measurements. This work presents a new method that removes the effects of a flexible fixture from an experimentally obtained modal model. It can be viewed as an extension to the approach where rigid masses are removed from a structure. The approach presented here improves the modal basis of the substructure, so that it can be used to more accurately estimate the modal parameters of the built-up system. New types of constraints are also presented, which constrain the modal degrees of freedom of the substructures, avoiding the need to estimate the connection point displacements and rotations. These constraints together with the use of a flexible fixture enable a new approach for joining structures, especially those with statically indeterminate multi-point connections, such as two circular flanges that are joined by many more bolts than required to enforce compatibility if the substructures were rigid. Fixture design is discussed, one objective of which is to achieve a mass-loaded boundary condition that exercises the substructure at the connection point as it is in the built up system. The proposed approach is demonstrated with two examples using experimental measurements from laboratory systems. The first is a simple problem of joining two beams of differing lengths, while the second consists of a three-dimensional structure comprising a circular plate that is bolted at eight locations to a flange on a cylindrical structure. In both cases frequency response functions predicted by the substructuring methods agree well with those of the actual coupled structures over a significant range of frequencies.

An alternative view of protein fold space.

PubMed

Shindyalov, I N; Bourne, P E

2000-02-15

Comparing and subsequently classifying protein structures information has received significant attention concurrent with the increase in the number of experimentally derived 3-dimensional structures. Classification schemes have focused on biological function found within protein domains and on structure classification based on topology. Here an alternative view is presented that groups substructures. Substructures are long (50-150 residue) highly repetitive near-contiguous pieces of polypeptide chain that occur frequently in a set of proteins from the PDB defined as structurally non-redundant over the complete polypeptide chain. The substructure classification is based on a previously reported Combinatorial Extension (CE) algorithm that provides a significantly different set of structure alignments than those previously described, having, for example, only a 40% overlap with FSSP. Qualitatively the algorithm provides longer contiguous aligned segments at the price of a slightly higher root-mean-square deviation (rmsd). Clustering these alignments gives a discreet and highly repetitive set of substructures not detectable by sequence similarity alone. In some cases different substructures represent all or different parts of well known folds indicative of the Russian doll effect--the continuity of protein fold space. In other cases they fall into different structure and functional classifications. It is too early to determine whether these newly classified substructures represent new insights into the evolution of a structural framework important to many proteins. What is apparent from on-going work is that these substructures have the potential to be useful probes in finding remote sequence homology and in structure prediction studies. The characteristics of the complete all-by-all comparison of the polypeptide chains present in the PDB and details of the filtering procedure by pair-wise structure alignment that led to the emergent substructure gallery are discussed. Substructure classification, alignments, and tools to analyze them are available at http://cl.sdsc.edu/ce.html.

Substructure analysis using NICE/SPAR and applications of force to linear and nonlinear structures. [spacecraft masts

NASA Technical Reports Server (NTRS)

Razzaq, Zia; Prasad, Venkatesh; Darbhamulla, Siva Prasad; Bhati, Ravinder; Lin, Cai

1987-01-01

Parallel computing studies are presented for a variety of structural analysis problems. Included are the substructure planar analysis of rectangular panels with and without a hole, the static analysis of space mast, using NICE/SPAR and FORCE, and substructure analysis of plane rigid-jointed frames using FORCE. The computations are carried out on the Flex/32 MultiComputer using one to eighteen processors. The NICE/SPAR runstream samples are documented for the panel problem. For the substructure analysis of plane frames, a computer program is developed to demonstrate the effectiveness of a substructuring technique when FORCE is enforced. Ongoing research activities for an elasto-plastic stability analysis problem using FORCE, and stability analysis of the focus problem using NICE/SPAR are briefly summarized. Speedup curves for the panel, the mast, and the frame problems provide a basic understanding of the effectiveness of parallel computing procedures utilized or developed, within the domain of the parameters considered. Although the speedup curves obtained exhibit various levels of computational efficiency, they clearly demonstrate the excellent promise which parallel computing holds for the structural analysis problem. Source code is given for the elasto-plastic stability problem and the FORCE program.

Effect of lensing non-Gaussianity on the CMB power spectra

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Antony; Pratten, Geraint, E-mail: antony@cosmologist.info, E-mail: geraint.pratten@gmail.com

2016-12-01

Observed CMB anisotropies are lensed, and the lensed power spectra can be calculated accurately assuming the lensing deflections are Gaussian. However, the lensing deflections are actually slightly non-Gaussian due to both non-linear large-scale structure growth and post-Born corrections. We calculate the leading correction to the lensed CMB power spectra from the non-Gaussianity, which is determined by the lensing bispectrum. Assuming no primordial non-Gaussianity, the lowest-order result gives ∼ 0.3% corrections to the BB and EE polarization spectra on small-scales. However we show that the effect on EE is reduced by about a factor of two by higher-order Gaussian lensing smoothing,more » rendering the total effect safely negligible for the foreseeable future. We give a simple analytic model for the signal expected from skewness of the large-scale lensing field; the effect is similar to a net demagnification and hence a small change in acoustic scale (and therefore out of phase with the dominant lensing smoothing that predominantly affects the peaks and troughs of the power spectrum).« less

Galaxy Cluster Mass Reconstruction Project – III. The impact of dynamical substructure on cluster mass estimates

DOE PAGES

Old, L.; Wojtak, R.; Pearce, F. R.; ...

2017-12-20

With the advent of wide-field cosmological surveys, we are approaching samples of hundreds of thousands of galaxy clusters. While such large numbers will help reduce statistical uncertainties, the control of systematics in cluster masses is crucial. Here we examine the effects of an important source of systematic uncertainty in galaxy-based cluster mass estimation techniques: the presence of significant dynamical substructure. Dynamical substructure manifests as dynamically distinct subgroups in phase-space, indicating an ‘unrelaxed’ state. This issue affects around a quarter of clusters in a generally selected sample. We employ a set of mock clusters whose masses have been measured homogeneously withmore » commonly used galaxy-based mass estimation techniques (kinematic, richness, caustic, radial methods). We use these to study how the relation between observationally estimated and true cluster mass depends on the presence of substructure, as identified by various popular diagnostics. We find that the scatter for an ensemble of clusters does not increase dramatically for clusters with dynamical substructure. However, we find a systematic bias for all methods, such that clusters with significant substructure have higher measured masses than their relaxed counterparts. This bias depends on cluster mass: the most massive clusters are largely unaffected by the presence of significant substructure, but masses are significantly overestimated for lower mass clusters, by ~ 10 percent at 10 14 and ≳ 20 percent for ≲ 10 13.5. Finally, the use of cluster samples with different levels of substructure can therefore bias certain cosmological parameters up to a level comparable to the typical uncertainties in current cosmological studies.« less

Galaxy Cluster Mass Reconstruction Project – III. The impact of dynamical substructure on cluster mass estimates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Old, L.; Wojtak, R.; Pearce, F. R.

With the advent of wide-field cosmological surveys, we are approaching samples of hundreds of thousands of galaxy clusters. While such large numbers will help reduce statistical uncertainties, the control of systematics in cluster masses is crucial. Here we examine the effects of an important source of systematic uncertainty in galaxy-based cluster mass estimation techniques: the presence of significant dynamical substructure. Dynamical substructure manifests as dynamically distinct subgroups in phase-space, indicating an ‘unrelaxed’ state. This issue affects around a quarter of clusters in a generally selected sample. We employ a set of mock clusters whose masses have been measured homogeneously withmore » commonly used galaxy-based mass estimation techniques (kinematic, richness, caustic, radial methods). We use these to study how the relation between observationally estimated and true cluster mass depends on the presence of substructure, as identified by various popular diagnostics. We find that the scatter for an ensemble of clusters does not increase dramatically for clusters with dynamical substructure. However, we find a systematic bias for all methods, such that clusters with significant substructure have higher measured masses than their relaxed counterparts. This bias depends on cluster mass: the most massive clusters are largely unaffected by the presence of significant substructure, but masses are significantly overestimated for lower mass clusters, by ~ 10 percent at 10 14 and ≳ 20 percent for ≲ 10 13.5. Finally, the use of cluster samples with different levels of substructure can therefore bias certain cosmological parameters up to a level comparable to the typical uncertainties in current cosmological studies.« less

Mass Profile Decomposition of the Frontier Fields Cluster MACS J0416-2403: Insights on the Dark-matter Inner Profile

NASA Astrophysics Data System (ADS)

Annunziatella, M.; Bonamigo, M.; Grillo, C.; Mercurio, A.; Rosati, P.; Caminha, G.; Biviano, A.; Girardi, M.; Gobat, R.; Lombardi, M.; Munari, E.

2017-12-01

We present a high-resolution dissection of the two-dimensional total mass distribution in the core of the Hubble Frontier Fields galaxy cluster MACS J0416.1‑2403, at z = 0.396. We exploit HST/WFC3 near-IR (F160W) imaging, VLT/Multi Unit Spectroscopic Explorer spectroscopy, and Chandra data to separate the stellar, hot gas, and dark-matter mass components in the inner 300 kpc of the cluster. We combine the recent results of our refined strong lensing analysis, which includes the contribution of the intracluster gas, with the modeling of the surface brightness and stellar mass distributions of 193 cluster members, of which 144 are spectroscopically confirmed. We find that, moving from 10 to 300 kpc from the cluster center, the stellar to total mass fraction decreases from 12% to 1% and the hot gas to total mass fraction increases from 3% to 9%, resulting in a baryon fraction of approximatively 10% at the outermost radius. We measure that the stellar component represents ∼30%, near the cluster center, and 15%, at larger clustercentric distances, of the total mass in the cluster substructures. We subtract the baryonic mass component from the total mass distribution and conclude that within 30 kpc (∼3 times the effective radius of the brightest cluster galaxy) from the cluster center the surface mass density profile of the total mass and global (cluster plus substructures) dark-matter are steeper and that of the diffuse (cluster) dark-matter is shallower than an NFW profile. Our current analysis does not point to a significant offset between the cluster stellar and dark-matter components. This detailed and robust reconstruction of the inner dark-matter distribution in a larger sample of galaxy clusters will set a new benchmark for different structure formation scenarios.

Rhesus monkey lens as an in vitro model for studying oxidative stress

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zigler, J.S. Jr.; Lucas, V.A.; Du, X.Y.

1989-10-01

Lenses from young rhesus monkeys were incubated in the presence of H{sub 2}O{sub 2} or oxygen radical generating systems to determine their suitability as a model for investigating lenticular oxidative stress. Additionally, direct comparisons were made between the effects found with the monkey lenses and those observed with cultured rat lenses exposed to the same oxidizing systems. As in earlier studies with rat lenses the monkey lenses exhibited impaired ability to actively accumulate from the medium radioactively labelled rubidium and choline following exposure to oxidative stress. Based on the effects of various scavengers of oxygen radicals it appeared that themore » mechanisms responsible for lens damage were the same for both rat and monkey lenses. However, rat lenses were damaged by lower concentrations of oxidants than were monkey lenses. It was concluded that oxidative stress affects both rat and monkey lenses by similar mechanisms but that lenses from monkeys, and probably other primates, are more resistant to these effects because they have better endogenous antioxidant defenses.« less

Mass-stiffness substructuring of an elastic metasurface for full transmission beam steering

NASA Astrophysics Data System (ADS)

Lee, Hyuk; Lee, Jun Kyu; Seung, Hong Min; Kim, Yoon Young

2018-03-01

The metasurface concept has a significant potential due to its novel wavefront-shaping functionalities that can be critically useful for ultrasonic and solid wave-based applications. To achieve the desired functionalities, elastic metasurfaces should cover full 2π phase shift and also acquire full transmission within subwavelength scale. However, they have not been explored much with respect to the elastic regime, because the intrinsic proportionality of mass-stiffness within the continuum elastic media causes an inevitable trade-off between abrupt phase shift and sufficient transmission. Our goal is to engineer an elastic metasurface that can realize an inverse relation between (amplified) effective mass and (weakened) stiffness in order to satisfy full 2π phase shift as well as full transmission. To achieve this goal, we propose a continuum elastic metasurface unit cell that is decomposed into two substructures, namely a mass-tuning substructure with a local dipolar resonator and a stiffness-tuning substructure composed of non-resonant multiply-perforated slits. We demonstrate analytically, numerically, and experimentally that this unique substructured unit cell can satisfy the required phase shift with high transmission. The substructuring enables independent tuning of the elastic properties over a wide range of values. We use a mass-spring model of the proposed continuum unit cell to investigate the working mechanism of the proposed metasurface. With the designed metasurface consisting of substructured unit cells embedded in an aluminum plate, we demonstrate that our metasurface can successfully realize anomalous steering and focusing of in-plane longitudinal ultrasonic beams. The proposed substructuring concept is expected to provide a new principle for the design of general elastic metasurfaces that can be used to efficiently engineer arbitrary wave profiles.

The effect of UV-blocking contact lenses as a therapy for canine chronic superficial keratitis.

PubMed

Denk, Nora; Fritsche, Jens; Reese, Sven

2011-05-01

To evaluate the effect of UV-blocking soft contact lenses in treatment for chronic superficial keratitus (CSK). Twenty six dogs with CSK were treated continuously with UV-blocking contact lenses for 6 months. A contact lens was placed on one eye of each dog; the other eye remained without a lens as a control eye. After this primary study, five of the dogs were further treated and they wore then contact lenses in both eyes. Continuously, all patients were concurrently treated topically with cyclosporine. The contact lenses were changed every 4 weeks and an ophthalmic examination performed. Evaluation criteria included corneal alterations as pigmentation, edema, pannus and vascularization. To determine the transmittance characteristics of the contact lenses before and after use, 32 contact lenses were measured with a UV-vis-NIR spectrophotometer. Pigmentation increased in eyes wearing lenses and in control eyes over the evaluation period of 6 months. Corneal edema increased in the eyes wearing lenses, but remained unaffected in the control eyes. A significant difference in the incidence of pannus and the extent of corneal vascularisation could not be evaluated. Adverse effects were noted in six cases (corneal edema and vascularisation, conjunctivitis, blepharospasm). All new lenses studied reduced UV-radiation to a safe level, whereas used lenses did not maintain their transmittance characteristics. No positive effect of UV-blocking contact lenses could be proven with the study design used. © 2011 American College of Veterinary Ophthalmologists.

Improving substructure identification accuracy of shear structures using virtual control system

NASA Astrophysics Data System (ADS)

Zhang, Dongyu; Yang, Yang; Wang, Tingqiang; Li, Hui

2018-02-01

Substructure identification is a powerful tool to identify the parameters of a complex structure. Previously, the authors developed an inductive substructure identification method for shear structures. The identification error analysis showed that the identification accuracy of this method is significantly influenced by the magnitudes of two key structural responses near a certain frequency; if these responses are unfavorable, the method cannot provide accurate estimation results. In this paper, a novel method is proposed to improve the substructure identification accuracy by introducing a virtual control system (VCS) into the structure. A virtual control system is a self-balanced system, which consists of some control devices and a set of self-balanced forces. The self-balanced forces counterbalance the forces that the control devices apply on the structure. The control devices are combined with the structure to form a controlled structure used to replace the original structure in the substructure identification; and the self-balance forces are treated as known external excitations to the controlled structure. By optimally tuning the VCS’s parameters, the dynamic characteristics of the controlled structure can be changed such that the original structural responses become more favorable for the substructure identification and, thus, the identification accuracy is improved. A numerical example of 6-story shear structure is utilized to verify the effectiveness of the VCS based controlled substructure identification method. Finally, shake table tests are conducted on a 3-story structural model to verify the efficacy of the VCS to enhance the identification accuracy of the structural parameters.

Novel SHM method to locate damages in substructures based on VARX models

NASA Astrophysics Data System (ADS)

Ugalde, U.; Anduaga, J.; Martínez, F.; Iturrospe, A.

2015-07-01

A novel damage localization method is proposed, which is based on a substructuring approach and makes use of Vector Auto-Regressive with eXogenous input (VARX) models. The substructuring approach aims to divide the monitored structure into several multi-DOF isolated substructures. Later, each individual substructure is modelled as a VARX model, and the health of each substructure is determined analyzing the variation of the VARX model. The method allows to detect whether the isolated substructure is damaged, and besides allows to locate and quantify the damage within the substructure. It is not necessary to have a theoretical model of the structure and only the measured displacement data is required to estimate the isolated substructure's VARX model. The proposed method is validated by simulations of a two-dimensional lattice structure.

A substructure coupling procedure applicable to general linear time-invariant dynamic systems

NASA Technical Reports Server (NTRS)

Howsman, T. G.; Craig, R. R., Jr.

1984-01-01

A substructure synthesis procedure applicable to structural systems containing general nonconservative terms is presented. In their final form, the nonself-adjoint substructure equations of motion are cast in state vector form through the use of a variational principle. A reduced-order mode for each substructure is implemented by representing the substructure as a combination of a small number of Ritz vectors. For the method presented, the substructure Ritz vectors are identified as a truncated set of substructure eigenmodes, which are typically complex, along with a set of generalized real attachment modes. The formation of the generalized attachment modes does not require any knowledge of the substructure flexible modes; hence, only the eigenmodes used explicitly as Ritz vectors need to be extracted from the substructure eigenproblem. An example problem is presented to illustrate the method.

Measuring the Mass Distribution in Z is Approximately 0.2 Cluster Lenses with XMM, HST and CFHT

NASA Technical Reports Server (NTRS)

2004-01-01

Being the most massive gravitationally bound objects in the Universe, clusters of galaxies are prime targets for studies of structure formation and evolution. Specifically the comoving space density of virialized clusters of a given mass (or X-ray temperature), but also the frequency and degree of substructure, as well as the shape of the cluster mass profile are quantities whose current values and evolution as a function of lookback time can provide important constraints on the cosmological and physical parameters of structure formation theories. The project funded by NASA grant NAG 5-10041 intended to take such studies to a new level by combining observations of a well-selected cluster sample by three state-of-the-art telescopes: HST, to accurately measure the mass distribution in the cluster core (approx. 0.5 h(sup -1)(sub 50) Mpc) via strong gravitational lensing; CFHT, to measure the large scale mass distribution out to approx. 3 Mpc via weak lensing; and XMM, to measure the gas density and temperature distribution accurately on intermediate scales < 1.5 Mpc. XMM plays a pivotal role in this context as the calibration of X-ray mass measurements through accurate, spatially resolved X-ray temperature measurements (particularly in the cosmologically most sensitive range of kT> 5 keV) is central to the questions outlined above. This set of observations promised to yield the best cluster mass measurements obtained so far for a representative sample, thus allowing us to: 1) Measure the high-mass end of the local cluster mass function; 2) Test predictions of a universal cluster mass profile; 3) calibrate the mass-temperature and temperature-luminosity relations for clusters and the scatter around these relations, which is vital for studies of cluster evolution using the X-ray temperature and X-ray luminosity functions.

MC 2: Mapping the dark matter distribution of the “Toothbrush” cluster RX J0603.3+4214 with Hubble Space Telescope and Subaru weak lensing

DOE PAGES

Jee, M. James; Dawson, William A.; Stroe, Andra; ...

2016-02-01

The galaxy cluster RX J0603.3+4214 at z = 0:225 is one of the rarest clusters boasting an extremely large ( 2 Mpc) radio relic. Because of the remarkable morphology of the relic, the cluster is nicknamed the \\Toothbrush Cluster". Although the cluster's underlying mass distribution is one of the critical pieces of information needed to reconstruct the merger scenario responsible for the puzzling radio relic morphology, its proximity to the Galactic plane b 10 has imposed signi cant observational challenges. We present a high-resolution weak-lensing study of the cluster with Subaru/Suprime Cam and Hubble Space Telescope imaging data. Our massmore » reconstruction reveals that the cluster is composed of complicated dark matter substructures closely tracing the galaxy distribution, in contrast, however, with the relatively simple binary X-ray morphology. Nevertheless, we nd that the cluster mass is still dominated by the two most massive clumps aligned north-south with a 3:1 mass ratio (M 200 = 6:29 +2:24 -1:62 X 10 14M⊙ and 1:98 +1:24 -0:74 X 10 14M⊙ for the northern and southern clumps, respectively). The southern mass peak is 20 o set toward the south with respect to the corresponding X-ray peak, which has a \\bullet"-like morphology pointing south. Comparison of the current weak- lensing result with the X-ray, galaxy, and radio relic suggests that perhaps the dominant mechanism responsible for the observed relic may be a high-speed collision of the two most massive subclusters, although the peculiarity of the morphology necessitates involvement of additional subclusters. Careful numerical simulations should follow in order to obtain more complete understanding of the merger scenario utilizing all existing observations.« less

Effect of cholesterol deposition on bacterial adhesion to contact lenses.

PubMed

Babaei Omali, Negar; Zhu, Hua; Zhao, Zhenjun; Ozkan, Jerome; Xu, Banglao; Borazjani, Roya; Willcox, Mark D P

2011-08-01

To examine the effect of cholesterol on the adhesion of bacteria to silicone hydrogel contact lenses. Contact lenses, collected from subjects wearing Acuvue Oasys or PureVision lenses, were extracted in chloroform:methanol (1:1, v/v) and amount of cholesterol was estimated by thin-layer chromatography. Unworn lenses were soaked in cholesterol, and the numbers of Pseudomonas aeruginosa strains or Staphylococcus aureus strains that adhered to the lenses were measured. Cholesterol was tested for effects on bacterial growth by incubating bacteria in medium containing cholesterol. From ex vivo PureVision lenses, 3.4 ± 0.3 μg/lens cholesterol was recovered, and from Acuvue Oasys lenses, 2.4 ± 0.2 to 1.0 ± 0.1 μg/lens cholesterol was extracted. Cholesterol did not alter the total or viable adhesion of any strain of P. aeruginosa or S. aureus (p > 0.05). However, worn PureVision lenses reduced the numbers of viable cells of P. aeruginosa (5.8 ± 0.4 log units) compared with unworn lenses (6.4 ± 0.2 log units, p = 0.001). Similarly, there were fewer numbers of S. aureus 031 adherent to worn PureVision (3.05 ± 0.8 log units) compared with unworn PureVision (4.6 ± 0.3 log units, p = 0.0001). Worn Acuvue Oasys lenses did not affect bacterial adhesion. Cholesterol showed no effect on the growth of any test strain. Although cholesterol has been shown to adsorb to contact lenses during wear, this lipid does not appear to modulate bacterial adhesion to a lens surface.

Reliability of power profiles measured on NIMO TR1504 (Lambda-X) and effects of lens decentration for single vision, bifocal and multifocal contact lenses.

PubMed

Kim, Eon; Bakaraju, Ravi C; Ehrmann, Klaus

2016-01-01

To evaluate the repeatability of power profiles measured on NIMO TR1504 (Lambda-X, Belgium) and investigate the effects of lens decentration on the power profiles for single vision (SV), bifocal (BF) and multifocal (MF) contact lenses. Accuracy of the sphere power was evaluated using single vision BK-7 calibration glass lenses of six minus and six plus powers. Three SV and four BF/MF contact lenses - three lenses each, were measured five times to calculate the coefficients of repeatability (COR) of the instrument. The COR was computed for each chord position, lens design, prescription power and operator. One lens from each type was measured with a deliberate decentration up to ±0.5mm in 0.1mm steps. For all lenses, the COR varied across different regions of the half-chord position. In general, SV lenses showed lower COR compared to the BF/MF group lenses. There were no noticeable trends of COR between prescription powers for SV and BF/MF lenses. The shape of the power profiles was not affected when lenses were deliberately decentered for all SV and PureVision MF lenses. However, for Acuvue BF lenses, the peak to trough amplitude of the power profiles flattened up to 1.00D. The COR across the half-chord of the optic zone diameter was mostly within clinical relevance except for the central 0.5mm half-chord position. COR were dependent on the lens type, whereby BF/MF group produced higher COR than SV lenses. The effects of deliberate decentration on the shape of power profiles were pronounced for lenses where the profiles had sharp transitions of power. Copyright © 2015 Spanish General Council of Optometry. Published by Elsevier Espana. All rights reserved.

Effect of Yellow-Tinted Lenses on Visual Attributes Related to Sports Activities

PubMed Central

Kohmura, Yoshimitsu; Murakami, Shigeki; Aoki, Kazuhiro

2013-01-01

The purpose of this study was to clarify the effect of colored lenses on visual attributes related to sports activities. The subjects were 24 students (11 females, 13 males; average age 21.0 ±1.2 years) attending a sports university. Lenses of 5 colors were used: colorless, light yellow, dark yellow, light gray, and dark gray. For each lens, measurements were performed in a fixed order: contrast sensitivity, dynamic visual acuity, depth perception, hand-eye coordination and visual acuity and low-contrast visual acuity. The conditions for the measurements of visual acuity and low-contrast visual acuity were in the order of Evening, Evening+Glare, Day, and Day+Glare. There were no significant differences among lenses in dynamic visual acuity and depth perception. For hand-eye coordination, time was significantly shorter with colorless than dark gray lenses. Contrast sensitivity was significantly higher with colorless, light yellow, and light gray lenses than with dark yellow and dark gray lenses. The low-contrast visual acuity test in the Day+Glare condition showed no significant difference among the lenses. In the Evening condition, low-contrast visual acuity was significantly higher with colorless and light yellow lenses than with dark gray lenses, and in the Evening+Glare condition, low-contrast visual acuity was significantly higher with colorless lenses than with the other colors except light yellow. Under early evening conditions and during sports activities, light yellow lenses do not appear to have an adverse effect on visual attributes. PMID:23717352

Spectral structure of electron antineutrinos from nuclear reactors.

PubMed

Dwyer, D A; Langford, T J

2015-01-09

Recent measurements of the positron energy spectrum obtained from inverse beta decay interactions of reactor electron antineutrinos show an excess in the 4 to 6 MeV region relative to current predictions. First-principles calculations of fission and beta decay processes within a typical pressurized water reactor core identify prominent fission daughter isotopes as a possible origin for this excess. These calculations also predict percent-level substructures in the antineutrino spectrum due to Coulomb effects in beta decay. Precise measurement of these substructures can elucidate the nuclear processes occurring within reactors. These substructures can be a systematic issue for measurements utilizing the detailed spectral shape.

Colored lenses suppress blue light-emitting diode light-induced damage in photoreceptor-derived cells.

PubMed

Hiromoto, Kaho; Kuse, Yoshiki; Tsuruma, Kazuhiro; Tadokoro, Nobuyuki; Kaneko, Nobuyuki; Shimazawa, Masamitsu; Hara, Hideaki

2016-03-01

Blue light-emitting diodes (LEDs) in liquid crystal displays emit high levels of blue light, exposure to which is harmful to the retina. Here, we investigated the protective effects of colored lenses in blue LED light-induced damage to 661W photoreceptor-derived cells. We used eight kinds of colored lenses and one lens that reflects blue light. Moreover, we evaluated the relationship between the protective effects of the lens and the transmittance of lens at 464 nm. Lenses of six colors, except for the SY, PN, and reflective coating lenses, strongly decreased the reduction in cell damage induced by blue LED light exposure. The deep yellow lens showed the most protective effect from all the lenses, but the reflective coating lens and pink lens did not show any effects on photoreceptor-derived cell damage. Moreover, these results were correlated with the lens transmittance of blue LED light (464 nm). These results suggest that lenses of various colors, especially deep yellow lenses, may protect retinal photoreceptor cells from blue LED light in proportion to the transmittance for the wavelength of blue LED and the suppression of reactive oxygen species production and cell damage.

Effect of phospholipid deposits on adhesion of bacteria to contact lenses.

PubMed

Babaei Omali, Negar; Proschogo, Nicholas; Zhu, Hua; Zhao, Zhenjun; Diec, Jennie; Borazjani, Roya; Willcox, Mark D P

2012-01-01

Protein and lipid deposits on contact lenses may contribute to clinical complications. This study examined the effect of phospholipids on the adhesion of bacteria to contact lenses. Worn balafilcon A (n = 11) and senofilcon A (n = 11) were collected after daily wear and phospholipids were extracted in chloroform:methanol. The amount of phospholipid was measured by electrospray ionization mass spectrometry. Unworn lenses soaked in phospholipids were exposed to Pseudomonas aeruginosa and Staphylococcus aureus. After 18 h incubation, the numbers of P. aeruginosa or S. aureus that adhered to the lenses were measured. Phospholipid was tested for possible effects on bacterial growth. A broad range of sphingomyelins (SM) and phosphatidylcholines (PC) were detected from both types of worn lenses. SM (16:0) (m/z 703) and PC (34:2) (m/z 758) were the major phospholipids detected in the lens extracts. Phospholipids did not alter the adhesion of any strain of P. aeruginosa or S. aureus (p > 0.05). Phospholipids (0.1 mg/mL) showed no effect on the growth of P. aeruginosa 6294 or S. aureus 031. Phospholipids adsorb/absorb to contact lenses during wear, however, the major types of phospholipids adsorbed to lenses do not alter bacterial adhesion or growth.

Modelling and control issues of dynamically substructured systems: adaptive forward prediction taken as an example

PubMed Central

Tu, Jia-Ying; Hsiao, Wei-De; Chen, Chih-Ying

2014-01-01

Testing techniques of dynamically substructured systems dissects an entire engineering system into parts. Components can be tested via numerical simulation or physical experiments and run synchronously. Additional actuator systems, which interface numerical and physical parts, are required within the physical substructure. A high-quality controller, which is designed to cancel unwanted dynamics introduced by the actuators, is important in order to synchronize the numerical and physical outputs and ensure successful tests. An adaptive forward prediction (AFP) algorithm based on delay compensation concepts has been proposed to deal with substructuring control issues. Although the settling performance and numerical conditions of the AFP controller are improved using new direct-compensation and singular value decomposition methods, the experimental results show that a linear dynamics-based controller still outperforms the AFP controller. Based on experimental observations, the least-squares fitting technique, effectiveness of the AFP compensation and differences between delay and ordinary differential equations are discussed herein, in order to reflect the fundamental issues of actuator modelling in relevant literature and, more specifically, to show that the actuator and numerical substructure are heterogeneous dynamic components and should not be collectively modelled as a homogeneous delay differential equation. PMID:25104902

Full-degrees-of-freedom frequency based substructuring

NASA Astrophysics Data System (ADS)

Drozg, Armin; Čepon, Gregor; Boltežar, Miha

2018-01-01

Dividing the whole system into multiple subsystems and a separate dynamic analysis is common practice in the field of structural dynamics. The substructuring process improves the computational efficiency and enables an effective realization of the local optimization, modal updating and sensitivity analyses. This paper focuses on frequency-based substructuring methods using experimentally obtained data. An efficient substructuring process has already been demonstrated using numerically obtained frequency-response functions (FRFs). However, the experimental process suffers from several difficulties, among which, many of them are related to the rotational degrees of freedom. Thus, several attempts have been made to measure, expand or combine numerical correction methods in order to obtain a complete response model. The proposed methods have numerous limitations and are not yet generally applicable. Therefore, in this paper an alternative approach based on experimentally obtained data only, is proposed. The force-excited part of the FRF matrix is measured with piezoelectric translational and rotational direct accelerometers. The incomplete moment-excited part of the FRF matrix is expanded, based on the modal model. The proposed procedure is integrated in a Lagrange Multiplier Frequency Based Substructuring method and demonstrated on a simple beam structure, where the connection coordinates are mainly associated with the rotational degrees of freedom.

Gravitational lenses and dark matter - Theory

NASA Technical Reports Server (NTRS)

Gott, J. Richard, III

1987-01-01

Theoretical models are presented for guiding the application of gravitational lenses to probe the characteristics of dark matter in the universe. Analytical techniques are defined for quantifying the mass associated with lensing galaxies (in terms of the image separation), determining the quantity of dark mass of the lensing bodies, and estimating the mass density of the lenses. The possibility that heavy halos are made of low mass stars is considered, along with the swallowing of central images of black holes or cusps in galactic nuclei and the effects produced on a lensed quasar image by nonbaryonic halos. The observable effects of dense groups and clusters and the characteristics of dark matter strings are discussed, and various types of images which are possible due to lensing phenomena and position are described.

Innovative FRF measurement technique for frequency based substructuring method

NASA Astrophysics Data System (ADS)

Mirza, W. I. I. Wan Iskandar; Rani, M. N. Abdul; Ayub, M. A.; Yunus, M. A.; Omar, R.; Mohd Zin, M. S.

2018-04-01

In this paper, frequency based substructuring (FBS) is used in an attempt to predict the dynamic behaviour of an assembled structure. The assembled structure which consists of two beam substructures namely substructure A (finite element model) and substructure B (experimental model) was tested. The FE model of substructure A was constructed by using 3D elements and the Frequency Response Functions (FRFs) were derived viaa FRF synthesis method. A specially customised bolt was used to allow the attachment of sensors and excitation to be made at theinterfaces of substructure B, and the FRFs were measured by using an impact testing method. Both substructures A and B were then coupled by using the FBS method for the prediction of FRFs. The coupled FRF obtained was validated with the measured FRF counterparts. This work revealed that by implementing a specially customised bolt during the measurement of FRF at the interface, led to an improvement in the FBS predicted results.

A Multi-wavelength Mass Analysis of RCS2 J232727.6-020437, A ˜3 × 1015 M⊙ Galaxy Cluster at z = 0.7

NASA Astrophysics Data System (ADS)

Sharon, K.; Gladders, M. D.; Marrone, D. P.; Hoekstra, H.; Rasia, E.; Bourdin, H.; Gifford, D.; Hicks, A. K.; Greer, C.; Mroczkowski, T.; Barrientos, L. F.; Bayliss, M.; Carlstrom, J. E.; Gilbank, D. G.; Gralla, M.; Hlavacek-Larrondo, J.; Leitch, E.; Mazzotta, P.; Miller, C.; Muchovej, S. J. C.; Schrabback, T.; Yee, H. K. C.; RCS-Team

2015-11-01

We present an initial study of the mass and evolutionary state of a massive and distant cluster, RCS2 J232727.6-020437. This cluster, at z = 0.6986, is the richest cluster discovered in the RCS2 project. The mass measurements presented in this paper are derived from all possible mass proxies: X-ray measurements, weak-lensing shear, strong lensing, Sunyaev-Zel’dovich effect decrement, the velocity distribution of cluster member galaxies, and galaxy richness. While each of these observables probe the mass of the cluster at a different radius, they all indicate that RCS2 J232727.6-020437 is among the most massive clusters at this redshift, with an estimated mass of {M}200˜ 3× {10}15{h}70-1 {M}⊙ . In this paper, we demonstrate that the various observables are all reasonably consistent with each other to within their uncertainties. RCS2 J232727.6-020437 appears to be well relaxed—with circular and concentric X-ray isophotes, with a cool core, and no indication of significant substructure in extensive galaxy velocity data. Based on observations obtained with : MegaPrime/MegaCam, a joint project of CFHT and CEA/DAPNIA, at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Science de l’Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii; the NASA/ESA Hubble Space Telescope (HST), obtained from the data archive at the Space Telescope Institute. STScI is operated by the association of Universities for Research in Astronomy, Inc. under the NASA contract NAS 5-2655; the 6.5 m Magellan telescopes located at Las Campanas Observatory, Chile;

The effect of multiple antireflective coatings and center thickness on resistance of polycarbonate spectacle lenses to penetration by pointed missiles.

PubMed

Chou, B Ralph; Gupta, Alina; Hovis, Jeffery K

2005-11-01

Previous work has shown that the impact resistance to blunt missiles is affected by coatings applied to either CR-39 or polycarbonate lenses. We investigated the effects of multiple antireflection (minimum angle of resolution [MAR]) coatings on the resistance of polycarbonate lenses to puncture on impact by sharp, high-speed missiles. Four groups of surfaced plano polycarbonate lenses were investigated. Two groups had a scratch-resistant (SR) coating applied to both surfaces. One of these groups had a 2-mm center thickness and the other had a 3-mm center thickness. The other two groups of 2-mm and 3-mm thick lenses had a MAR coating applied over the SR coating. The lenses were impacted by a missile consisting of an industrial sewing machine needle mounted in a cylindrical aluminum carrier. The sharp missiles were able to pierce the lenses at speeds between 29.6 m/s and 46.2 m/s. Impact resistance was lowest for the thinner lenses and lenses with a MAR coating. The effect of the MAR and lens thickness was subadditive. We have confirmed previous observations that polycarbonate lenses are more susceptible to penetration by sharp, high-speed missiles than blunt missiles. We have also found that reducing lens center thickness and applying a MAR coating further reduces the penetration resistance. Therefore, the use of 2-mm center thickness and MAR-coated polycarbonate lenses should be discouraged for industrial eye protectors where sharp missile hazards are possible.

Optical Substructure and BCG Offsets of Sunyaev-Zel'dovich and X-ray Selected Galaxy Clusters

NASA Astrophysics Data System (ADS)

Lopes, Paulo AA; Trevisan, M.; Laganá, T. F.; Durret, F.; Ribeiro, A. LB; Rembold, S. B.

2018-05-01

We used optical imaging and spectroscopic data to derive substructure estimates for local Universe (z < 0.11) galaxy clusters from two different samples. The first was selected through the Sunyaev-Zel'dovich (SZ) effect by the Planck satellite and the second is an X-ray selected sample. In agreement to X-ray substructure estimates we found that the SZ systems have a larger fraction of substructure than the X-ray clusters. We have also found evidence that the higher mass regime of the SZ clusters, compared to the X-ray sample, explains the larger fraction of disturbed objects in the Planck data. Although we detect a redshift evolution in the substructure fraction, it is not sufficient to explain the different results between the higher-z SZ sample and the X-ray one. We have also verified a good agreement (˜60%) between the optical and X-ray substructure estimates. However, the best level of agreement is given by the substructure classification given by measures based on the brightest cluster galaxy (BCG), either the BCG-X-ray centroid offset, or the magnitude gap between the first and second BCGs. We advocate the use of those two parameters as the most reliable and cheap way to assess cluster dynamical state. We recommend an offset cut of ˜0.01 ×R500 to separate relaxed and disturbed clusters. Regarding the magnitude gap the separation can be done at Δm12 = 1.0. The central galaxy paradigm (CGP) may not be valid for ˜20% of relaxed massive clusters. This fraction increases to ˜60% for disturbed systems.

Direct probe of dark energy through gravitational lensing effect

DOE Office of Scientific and Technical Information (OSTI.GOV)

He, Hong-Jian; Zhang, Zhen, E-mail: hjhe@tsinghua.edu.cn, E-mail: zh.zhang@pku.edu.cn

We show that gravitational lensing can provide a direct method to probe the nature of dark energy at astrophysical scales. For lensing system as an isolated astrophysical object, we derive the dark energy contribution to gravitational potential as a repulsive power-law term, containing a generic equation of state parameter w . We find that it generates w -dependent and position-dependent modification to the conventional light orbital equation of w =−1. With post-Newtonian approximation, we compute its direct effect for an isolated lensing system at astrophysical scales and find that the dark energy force can deflect the path of incident lightmore » rays. We demonstrate that the dark-energy-induced deflection angle Δα{sub DE}∝ M {sup (1+1/3} {sup w} {sup )} (with 1+1/3 w > 0), which increases with the lensing mass M and consistently approaches zero in the limit M → 0. This effect is distinctive because dark energy tends to diffuse the rays and generates concave lensing effect . This is in contrast to the conventional convex lensing effect caused by both visible and dark matter. Measuring such concave lensing effect can directly probe the existence and nature of dark energy. We estimate this effect and show that the current gravitational lensing experiments are sensitive to the direct probe of dark energy at astrophysical scales. For the special case w =−1, our independent study favors the previous works that the cosmological constant can affect light bending, but our prediction qualitatively and quantitatively differ from the literature, including our consistent realization of Δα{sub DE} → 0 (under 0 M → ) at the leading order.« less

A Feasibility Study of Synthesizing Subsurfaces Modeled with Computational Neural Networks

NASA Technical Reports Server (NTRS)

Wang, John T.; Housner, Jerrold M.; Szewczyk, Z. Peter

1998-01-01

This paper investigates the feasibility of synthesizing substructures modeled with computational neural networks. Substructures are modeled individually with computational neural networks and the response of the assembled structure is predicted by synthesizing the neural networks. A superposition approach is applied to synthesize models for statically determinate substructures while an interface displacement collocation approach is used to synthesize statically indeterminate substructure models. Beam and plate substructures along with components of a complicated Next Generation Space Telescope (NGST) model are used in this feasibility study. In this paper, the limitations and difficulties of synthesizing substructures modeled with neural networks are also discussed.

An Impulse Based Substructuring approach for impact analysis and load case simulations

NASA Astrophysics Data System (ADS)

Rixen, Daniel J.; van der Valk, Paul L. C.

2013-12-01

In the present paper we outline the basic theory of assembling substructures for which the dynamics are described as Impulse Response Functions. The assembly procedure computes the time response of a system by evaluating per substructure the convolution product between the Impulse Response Functions and the applied forces, including the interface forces that are computed to satisfy the interface compatibility. We call this approach the Impulse Based Substructuring method since it transposes to the time domain the Frequency Based Substructuring approach. In the Impulse Based Substructuring technique the Impulse Response Functions of the substructures can be gathered either from experimental tests using a hammer impact or from time-integration of numerical submodels. In this paper the implementation of the method is outlined for the case when the impulse responses of the substructures are computed numerically. A simple bar example is shown in order to illustrate the concept. The Impulse Based Substructuring allows fast evaluation of impact response of a structure when the impulse response of its components is known. It can thus be used to efficiently optimize designs of consumer products by including impact behavior at the early stage of the design, but also for performing substructured simulations of complex structures such as offshore wind turbines.

The Effects of Physically Unrelated Near Neighbors on the Weak Galaxy-Galaxy Lensing Signal

NASA Astrophysics Data System (ADS)

Brainerd, Tereasa

2018-01-01

The effects of physically unrelated near neighbors on the weak galaxy-galaxy lensing signal are explored. Physically unrelated near neighbors are galaxies that are close to a given lens galaxy in projection on the sky, but are located at substantially different redshifts. Typically, the effects of such physically unrelated near neighbors are assumed to cancel. If that were truly the case, these objects would not contribute to the mean tangential shear around the lenses and they can be ignored when using an observed weak lensing signal to infer the excess surface mass density surrounding a set of lens galaxies. Here, observed galaxies with known redshifts and luminosities are used as the basis of a suite of Monte Carlo simluations of weak galaxy-galaxy lensing. The simulations incorporate the intrinsic clustering of the lens galaxies, as well as the intrinsic distribution of the lens galaxy masses. Dark matter halos of appropriate sizes and masses are assigned to each of the lens galaxies, and the net effect of all lenses on a set of background source galaxies is determined. The net weak lensing signal (i.e., the mean tangential shear due to all lenses along the line of sight) is computed and then compared to the excess surface mass density surrounding the lenses. Due to the broad redshift and mass distributions of the lenses, the effects of physically unrelated near neighbors in the simulations do not cancel. On scales equal to or greater than the scale for which the two-halo term contributes substantially to the shear, this non-cancellation of the effects of physically unrelated near neighbors significantly affects the accuracy with which the excess surface mass density may be inferred from the mean tangential shear via the standard formula: < ΔΣ > = < Σc γt > . The effects of physically unrelated near neighbors are greatest for the least massive lens galaxies but can also be important for the most massive lens galaxies.

Strong Lens Models for Massive Galaxy Clusters in the Reionization Lensing Cluster Survey

NASA Astrophysics Data System (ADS)

Cerny, Catherine; Sharon, Keren; Coe, Dan A.; Paterno-Mahler, Rachel; Jones, Christine; Czakon, Nicole G.; Umetsu, Keiichi; Stark, Daniel; Bradley, Larry D.; Trenti, Michele; Johnson, Traci; Bradac, Marusa; Dawson, William; Rodney, Steven A.; Strolger, Louis-Gregory; RELICS Team

2017-01-01

We present strong lensing models for five galaxy clusters from the Planck SZ cluster catalog as a part of the Reionization Lensing Cluster Survey (RELICS), a program that seeks to constrain the galaxy luminosity function past z~9 by conducting a wide field survey of massive galaxy clusters with HST (GO-14096, PI: Coe). The strong gravitational lensing effects of these clusters significantly magnify background galaxies, which enhances our ability to discover the large numbers of high redshift galaxies at z~9-12 needed to create a representative sample. We use strong lensing models for these clusters to study their mass distribution and magnification, which allows us to quantify the lensing effect on the background galaxies. These models can then be utilized in the RELICS survey in order to identify high redshift galaxy candidates that may be lensed by the clusters. The intrinsic properties of these galaxy candidates can be derived by removing the lensing effect as predicted by our models, which will meet the science goals of the RELICS survey. We use HST WFC3 and ACS imaging to create lensing models for the clusters RXC J0142.9+4438, ACO-2537, ACO-2163, RXCJ2211.7-0349, and ACT-CLJ0102-49151.

The effects of two different types of bandage contact lenses on the healthy canine eye.

PubMed

Braus, Barbara Katharina; Riedler, Daniela; Tichy, Alexander; Spergser, Joachim; Schwendenwein, Ilse

2018-02-06

To compare two types of bandage contact lenses on the healthy canine eye. Six healthy Beagles. Two different types of bandage contact lenses (single sized human silicone contact lens 'PureVision 2' (Bausch & Lomb Incorporated, Rochester, NY, USA) and specially designed veterinary hydrogel contact lens 'AcriVet Pat D' (Bausch & Lomb Incorporated) were placed in 12 eyes of healthy Beagle dogs. Retention times and the effects of the lenses regarding irritation of the eye, changes in tear production, impact of contact lenses on tonometric readings, and cytologic and microbiological alterations of the canine eye were investigated. Mean retention times for veterinary hydrogel lenses with special dimensions were significantly shorter (2 days) than for one size human silicon lenses (8.8 days). Irritation scores were overall low for both types of lenses apart from one human lens causing severe irritation and keratoconjunctivitis as a sequel to folding and displacement. Tear production remained stable in human contact lenses. Intraocular pressure readings with a contact lens in place were only slightly altered; the most accurate readings were obtained through a human lens with an applanation tonometer. Cytology revealed a slight, nonsignificant increase in neutrophilic granulocytes with both types of lenses; the microflora did not change significantly. Human silicone lenses have significantly longer retention times and are less expensive than veterinary hydrogel lenses. In regard to irritation, bacterial growth and inflammation, both types of lenses can be recommended for use in canine eyes. © 2018 American College of Veterinary Ophthalmologists.

The effect of clulstering of galaxies on the statistics of gravitational lenses

NASA Technical Reports Server (NTRS)

Anderson, N.; Alcock, C.

1986-01-01

It is examined whether clustering of galaxies can significantly alter the statistical properties of gravitational lenses? Only models of clustering that resemble the observed distribution of galaxies in the properties of the two-point correlation function are considered. Monte-Carlo simulations of the imaging process are described. It is found that the effect of clustering is too small to be significant, unless the mass of the deflectors is so large that gravitational lenses become common occurrences. A special model is described which was concocted to optimize the effect of clustering on gravitational lensing but still resemble the observed distribution of galaxies; even this simulation did not satisfactorily produce large numbers of wide-angle lenses.

The wave-based substructuring approach for the efficient description of interface dynamics in substructuring

NASA Astrophysics Data System (ADS)

Donders, S.; Pluymers, B.; Ragnarsson, P.; Hadjit, R.; Desmet, W.

2010-04-01

In the vehicle design process, design decisions are more and more based on virtual prototypes. Due to competitive and regulatory pressure, vehicle manufacturers are forced to improve product quality, to reduce time-to-market and to launch an increasing number of design variants on the global market. To speed up the design iteration process, substructuring and component mode synthesis (CMS) methods are commonly used, involving the analysis of substructure models and the synthesis of the substructure analysis results. Substructuring and CMS enable efficient decentralized collaboration across departments and allow to benefit from the availability of parallel computing environments. However, traditional CMS methods become prohibitively inefficient when substructures are coupled along large interfaces, i.e. with a large number of degrees of freedom (DOFs) at the interface between substructures. The reason is that the analysis of substructures involves the calculation of a number of enrichment vectors, one for each interface degree of freedom (DOF). Since large interfaces are common in vehicles (e.g. the continuous line connections to connect the body with the windshield, roof or floor), this interface bottleneck poses a clear limitation in the vehicle noise, vibration and harshness (NVH) design process. Therefore there is a need to describe the interface dynamics more efficiently. This paper presents a wave-based substructuring (WBS) approach, which allows reducing the interface representation between substructures in an assembly by expressing the interface DOFs in terms of a limited set of basis functions ("waves"). As the number of basis functions can be much lower than the number of interface DOFs, this greatly facilitates the substructure analysis procedure and results in faster design predictions. The waves are calculated once from a full nominal assembly analysis, but these nominal waves can be re-used for the assembly of modified components. The WBS approach thus enables efficient structural modification predictions of the global modes, so that efficient vibro-acoustic design modification, optimization and robust design become possible. The results show that wave-based substructuring offers a clear benefit for vehicle design modifications, by improving both the speed of component reduction processes and the efficiency and accuracy of design iteration predictions, as compared to conventional substructuring approaches.

Gravitational lensing and the Lyman-alpha forest

NASA Technical Reports Server (NTRS)

Ikeuchi, Satoru; Turner, Edwin L.

1991-01-01

Possible connections between the inhomogeneities responsible for the Lyman-alpha forest in quasar spectra and gravitational lensing effects are investigated. For most models of the Lyman-alpha forest, no significant lensing is expected. For some versions of the CDM model-based minihalo hypothesis, gravitational lensings on scales less than abour 0.1 arcsec would occur with a frequency approaching that with which ordinary galaxies cause arcsecond scale lensing.

The effect of protein-coated contact lenses on the adhesion and viability of gram negative bacteria.

PubMed

Williams, Timothy J; Schneider, Rene P; Willcox, Mark D P

2003-10-01

Gram negative bacterial adhesion to contact lenses can cause adverse responses. During contact lens wear, components of the tear film adsorb to the contact lens. This study aimed to investigate the effect of this conditioning film on the viability of bacteria. Bacteria adhered to contact lenses which were either unworn, worn for daily-, extended- or overnight-wear or coated with lactoferrin or lysozyme. Numbers of viable and total cells were estimated. The number of viable attached cells was found to be significantly lower than the total number of cells on worn (50% for strain Paer1 on daily-wear lenses) or lactoferrin-coated lenses (56% for strain Paer1). Lysozyme-coated lenses no statistically significant effect on adhesion. The conditioning film gained through wear may not inhibit bacterial adhesion, but may act adversely upon those bacteria that succeed in attaching.

The motion of interconnected flexible bodies

NASA Technical Reports Server (NTRS)

Hopkins, A. S.

1975-01-01

The equations of motion for an arbitrarily interconnected collection of substructures are derived. The substructures are elastic bodies which may be idealized as finite element assemblies and are subject to small deformations relative to a nominal state. Interconnections between the elastic substructures permit large relative translations and rotations between substructures, governed by Pfaffian constraints describing the connections. Screw connections (permitting rotation about and translation along a single axis) eliminate constraint forces and incorporate modal coupling. The problem of flexible spacecraft simulation is discussed. Hurty's component mode approach is extended by permitting interconnected elastic substructures large motions relative to each other and relative to inertial space. The hybrid coordinate methods are generalized by permitting all substructures to be flexible (rather than only the terminal members of a topological tree of substructures). The basic relationships of continuum mechanics are developed.

The Gaussian Plasma Lens in Astrophysics: Refraction

NASA Astrophysics Data System (ADS)

Clegg, Andrew W.; Fey, Alan L.; Lazio, T. Joseph W.

1998-03-01

We present the geometrical optics for refraction of a distant background radio source by an interstellar plasma lens, with specific application to a lens with a Gaussian profile of free-electron column density. The refractive properties of the lens are specified completely by a dimensionless parameter α, which is a function of the wavelength of observation, the free-electron column density through the lens, the lens-observer distance, and the diameter of the lens transverse to the line of sight. A lens passing between the observer and a background source, due to the relative motions of the observer, lens, and source, produces modulations in the light curve of the background source. Because plasma lenses are diverging, the light curve displays a minimum in the background source's flux density, formed when the lens is on-axis, surrounded by enhancements above the nominal (unlensed) flux density. The exact form of the light curve depends only upon the parameter α and the relative angular sizes of the source and lens as seen by the observer. Other effects due to lensing include the following: (1) the formation of caustic surfaces, upon which the apparent brightness of the background source becomes very large; (2) the possible creation of multiple images of the background source; and (3) angular position wander of the background source. If caustics are formed, the separation of the outer caustics can be used to constrain α, while the separation of the inner caustics can constrain the size of the lens. We apply our analysis to two sources, which have undergone extreme scattering events: (1) 0954+658, a source for which we can identify multiple caustics in its light curve, and (2) 1741-038, for which polarization observations were obtained during and after the scattering event. We find general agreement between modeled and observed light curves at 2.25 GHz, but poor agreement at 8.1 GHz. The discrepancies between the modeled and observed light curves may result from some combination of substructure within the lens, an anisotropic lens shape, a lens which only grazes the source rather than passing completely over it, or unresolved substructure within the extragalactic sources. Our analysis also allows us to place constraints on the physical characteristics of the lens. The inferred properties of the lens responsible for the scattering event toward 0954+658 (1741-038) are that it was 0.38 AU (0.065 AU) in diameter with a peak column density of 0.24 pc cm-3 (10-4 pc cm-3), an electron density within the lens of 105 cm-3 (300 cm-3), and a mass of 6.5 × 10-14 M⊙ (10-18 M⊙). The angular position wander caused by the lens was 250 mas (0.4 mas) at 2.25 GHz. In the case of 1741-038, we can place an upper limit of only 100 mG on the magnetic field within the lens.

Microbial adhesion to silicone hydrogel lenses: a review.

PubMed

Willcox, Mark D P

2013-01-01

Microbial adhesion to contact lenses is believed to be one of the initiating events in the formation of many corneal infiltrative events, including microbial keratitis, that occur during contact lens wear. The advent of silicone hydrogel lenses has not reduced the incidence of these events. This may partly be related to the ability of microbes to adhere to these lenses. The aim of this study was to review the published literature on microbial adhesion to contact lenses, focusing on adhesion to silicone hydrogel lenses. The literature on microbial adhesion to contact lenses was searched, along with associated literature on adverse events that occur during contact lens wear. Particular reference was paid to the years 1995 through 2012 because this encompasses the time when the first clinical trials of silicone hydrogel lenses were reported, and their commercial availability and the publication of epidemiology studies on adverse events were studied. In vitro studies of bacterial adhesion to unworn silicone hydrogel lens have shown that generally, bacteria adhere to these lenses in greater numbers than to the hydroxyethyl methacrylate-based soft lenses. Lens wear has different effects on microbial adhesion, and this is dependent on the type of lens and microbial species/genera that is studied. Biofilms that can be formed on any lens type tend to protect the bacteria and fungi from the effects on disinfectants. Fungal hyphae can penetrate the surface of most types of lenses. Acanthamoeba adhere in greater numbers to first-generation silicone hydrogel lenses compared with the second-generation or hydroxyethyl methacrylate-based soft lenses. Microbial adhesion to silicone hydrogel lenses occurs and is associated with the production of corneal infiltrative events during lens wear.

Efficiency analysis of numerical integrations for finite element substructure in real-time hybrid simulation

NASA Astrophysics Data System (ADS)

Wang, Jinting; Lu, Liqiao; Zhu, Fei

2018-01-01

Finite element (FE) is a powerful tool and has been applied by investigators to real-time hybrid simulations (RTHSs). This study focuses on the computational efficiency, including the computational time and accuracy, of numerical integrations in solving FE numerical substructure in RTHSs. First, sparse matrix storage schemes are adopted to decrease the computational time of FE numerical substructure. In this way, the task execution time (TET) decreases such that the scale of the numerical substructure model increases. Subsequently, several commonly used explicit numerical integration algorithms, including the central difference method (CDM), the Newmark explicit method, the Chang method and the Gui-λ method, are comprehensively compared to evaluate their computational time in solving FE numerical substructure. CDM is better than the other explicit integration algorithms when the damping matrix is diagonal, while the Gui-λ (λ = 4) method is advantageous when the damping matrix is non-diagonal. Finally, the effect of time delay on the computational accuracy of RTHSs is investigated by simulating structure-foundation systems. Simulation results show that the influences of time delay on the displacement response become obvious with the mass ratio increasing, and delay compensation methods may reduce the relative error of the displacement peak value to less than 5% even under the large time-step and large time delay.

Substructural controller synthesis

NASA Technical Reports Server (NTRS)

Su, Tzu-Jeng; Craig, Roy R., Jr.

1989-01-01

A decentralized design procedure which combines substructural synthesis, model reduction, decentralized controller design, subcontroller synthesis, and controller reduction is proposed for the control design of flexible structures. The structure to be controlled is decomposed into several substructures, which are modeled by component mode synthesis methods. For each substructure, a subcontroller is designed by using the linear quadratic optimal control theory. Then, a controller synthesis scheme called Substructural Controller Synthesis (SCS) is used to assemble the subcontrollers into a system controller, which is to be used to control the whole structure.

Material properties that predict preservative uptake for silicone hydrogel contact lenses.

PubMed

Green, J Angelo; Phillips, K Scott; Hitchins, Victoria M; Lucas, Anne D; Shoff, Megan E; Hutter, Joseph C; Rorer, Eva M; Eydelman, Malvina B

2012-11-01

To assess material properties that affect preservative uptake by silicone hydrogel lenses. We evaluated the water content (using differential scanning calorimetry), effective pore size (using probe penetration), and preservative uptake (using high-performance liquid chromatography with spectrophotometric detection) of silicone and conventional hydrogel soft contact lenses. Lenses grouped similarly based on freezable water content as they did based on total water content. Evaluation of the effective pore size highlighted potential differences between the surface-treated and non-surface-treated materials. The water content of the lens materials and ionic charge are associated with the degree of preservative uptake. The current grouping system for testing contact lens-solution interactions separates all silicone hydrogels from conventional hydrogel contact lenses. However, not all silicone hydrogel lenses interact similarly with the same contact lens solution. Based upon the results of our research, we propose that the same material characteristics used to group conventional hydrogel lenses, water content and ionic charge, can also be used to predict uptake of hydrophilic preservatives for silicone hydrogel lenses. In addition, the hydrophobicity of silicone hydrogel contact lenses, although not investigated here, is a unique contact lens material property that should be evaluated for the uptake of relatively hydrophobic preservatives and tear components.

Prevention of bacterial colonization of contact lenses with covalently attached selenium and effects on the rabbit cornea.

PubMed

Mathews, Steven M; Spallholz, Julian E; Grimson, Mark J; Dubielzig, Richard R; Gray, Tracy; Reid, Ted W

2006-08-01

Although silicone hydrogel materials have produced many corneal health benefits to patients wearing contact lenses, bacteria that cause acute red eye or corneal ulcers are still a concern. A coating that inhibits bacterial colonization while not adversely affecting the cornea should improve the safety of contact lens wear. A covalent selenium (Se) coating on contact lenses was evaluated for safety using rabbits and prevention of bacterial colonization of the contact lenses in vitro. Contact lenses coated with Se were worn on an extended-wear schedule for up to 2 months by 10 New Zealand White rabbits. Corneal health was evaluated with slit-lamp biomicroscopy, pachymetry, electron microscopy, and histology. Lenses worn by the rabbits were analyzed for protein and lipid deposits. In addition, the ability of Se to block bacterial colonization was tested in vitro by incubating lenses in a Pseudomonas aeruginosa broth followed by scanning electron microscopy of the contact lens surface. The covalent Se coating decreased bacterial colonization in vitro while not adversely affecting the corneal health of rabbits in vivo. The Se coating produced no noticeable negative effects as observed with slit-lamp biomicroscopy, pachymetry, electron microscopy, and histology. The Se coating did not affect protein or lipid deposition on the contact lenses. The data from this pilot study suggest that a Se coating on contact lenses might reduce acute red eye and bacterial ulceration because of an inhibition of bacterial colonization. In addition, our safety tests suggest that this positive effect can be produced without an adverse effect on corneal health.

On- and off-eye spherical aberration of soft contact lenses and consequent changes of effective lens power.

PubMed

Dietze, Holger H; Cox, Michael J

2003-02-01

Soft contact lenses produce a significant level of spherical aberration affecting their power on-eye. A simple model assuming that a thin soft contact lens aligns to the cornea predicts that these effects are similar on-eye and off-eye. The wavefront aberration for 17 eyes and 33 soft contact lenses on-eye was measured with a Shack-Hartmann wavefront sensor. The Zernike coefficients describing the on-eye spherical aberration of the soft contact lens were compared with off-eye ray-tracing results. Paraxial and effective lens power changes were determined. The model predicts the on-eye spherical aberration of soft contact lenses closely. The resulting power change for a +/- 7.00 D spherical soft contact lens is +/- 0.5 D for a 6-mm pupil diameter and +/- 0.1 D for a 3-mm pupil diameter. Power change is negligible for soft contact lenses corrected for off-eye spherical aberration. For thin soft contact lenses, the level of spherical aberration and the consequent power change is similar on-eye and off-eye. Soft contact lenses corrected for spherical aberration in air will be expected to be aberration-free on-eye and produce only negligibly small power changes. For soft contact lenses without aberration correction, for higher levels of ametropia and large pupils, the soft contact lens power should be determined with trial lenses with their power and p value similar to the prescribed lens. The benefit of soft contact lenses corrected for spherical aberration depends on the level of ocular spherical aberration.

Evaluation of a timber column bent substructure after more than 60 years in-service

Treesearch

James P. Wacker; Xiping Wang; Douglas R. Rammer; William J. Nelson

2011-01-01

This paper describes both the field evaluation and laboratory testing of two timber-column-bent bridge substructures. These substructures served as intermediate pier supports for the East Deer Park Drive Bridge located in Gaithersburg, Maryland. A field evaluation of the bridge substructure was conducted in September 2008. Nondestructive testing was performed with a...

A Search for Starless Core Substructure in Ophiuchus

NASA Astrophysics Data System (ADS)

Kirk, Helen

2017-06-01

Density substructure is expected in evolved starless cores: a single peak to form a protostar, or multiple peaks from fragmentation. Searches for this substructure have had mixed success. In an ALMA survey of Ophiuchus, we find two starless cores with signs of substructure, consistent with simulation predictions. A similar survey in Chameleon (Dunham et al. 2016) had no detections, despite expecting at least two. Our results suggest that Chamleon may lack a more evolved starless cores. Future ALMA observations will better trace the influence of environment on core substructure formation.

Boosted objects and jet substructure at the LHC. Report of BOOST2012, held at IFIC Valencia, 23rd–27th of July 2012

DOE PAGES

Altheimer, A.; Arce, A.; Asquith, L.; ...

2014-03-21

This report of the BOOST2012 workshop presents the results of four working groups that studied key aspects of jet substructure. We discuss the potential of first-principle QCD calculations to yield a precise description of the substructure of jets and study the accuracy of state-of-the-art Monte Carlo tools. Limitations of the experiments’ ability to resolve substructure are evaluated, with a focus on the impact of additional (pile-up) proton proton collisions on jet substructure performance in future LHC operating scenarios. The final section summarizes the lessons learnt from jet substructure analyses in searches for new physics in the production of boosted topmore » quarks.« less

Lensing bias to CMB measurements of compensated isocurvature perturbations

NASA Astrophysics Data System (ADS)

Heinrich, Chen He; Grin, Daniel; Hu, Wayne

2016-08-01

Compensated isocurvature perturbations (CIPs) are modes in which the baryon and dark matter density fluctuations cancel. They arise in the curvaton scenario as well as some models of baryogenesis. While they leave no observable effects on the cosmic microwave background (CMB) at linear order, they do spatially modulate two-point CMB statistics and can be reconstructed in a manner similar to gravitational lensing. Due to the similarity between the effects of CMB lensing and CIPs, lensing contributes nearly Gaussian random noise to the CIP estimator that approximately doubles the reconstruction noise power. Additionally, the cross correlation between lensing and the integrated Sachs-Wolfe effect generates a correlation between the CIP estimator and the temperature field even in the absence of a correlated CIP signal. For cosmic-variance limited temperature measurements out to multipoles l ≤2500 , subtracting a fixed lensing bias degrades the detection threshold for CIPs by a factor of 1.3, whether or not they are correlated with the adiabatic mode.

Protein deposition and its effect on bacterial adhesion to contact lenses.

PubMed

Omali, Negar Babaei; Zhu, Hua; Zhao, Zhenjun; Willcox, Mark D P

2013-06-01

Bacterial adhesion to contact lenses is believed to be the initial step for the development of several adverse reactions that occur during lens wear such as microbial keratitis. This study examined the effect of combinations of proteins on the adhesion of bacteria to contact lenses. Unworn balafilcon A and senofilcon A lenses were soaked in commercially available pure protein mixtures to achieve the same amount of various proteins as found ex vivo. These lenses were then exposed to Pseudomonas aeruginosa and Staphylococcus aureus. Following incubation, the numbers of P. aeruginosa or S. aureus that adhered to the lenses were measured. The possible effect of proteins on bacterial growth was investigated by incubating bacteria in medium containing protein. Although there was a significant (p < 0.003) increase in the total or viable counts of one strain of S. aureus (031) on balafilcon A lenses soaked in the lysozyme/lactoferrin combination, the protein adhered to lenses did not alter the adhesion of any other strains of P. aeruginosa or S. aureus (p > 0.05). Growth of S. aureus 031 (p < 0.0001) but not of P. aeruginosa 6294 was stimulated by addition of lysozyme/lactoferrin combination (2.8/0.5 mg/mL). Addition of lipocalin did not affect the growth of any strains tested (p > 0.05). Adsorption of amounts of lysozyme and lactoferrin or lipocalin equivalent to those extracted from worn contact lenses did not affect the adhesion of most strains of S. aureus or P. aeruginosa to lens surfaces.

Statistics of gravitational lenses - The uncertainties

NASA Technical Reports Server (NTRS)

Mao, Shude

1991-01-01

The assumptions in the analysis of gravitational lensing statistics are examined. Special emphasis is given to the uncertainties in the theoretical predictions. It is shown that a simple redshift cutoff model, which may result from galaxy evolution, can significantly reduce the lensing probability and explain the large mean separation of images in observed gravitational lenses. This effect may affect the constraint on the contribution of the cosmological constant to producing a flat universe from the number counts of the observed lenses. For the Omega(0) = 1 (filled beam) model, the lensing probability of early-type galaxies with finite core radii is reduced roughly by a factor of 2 for high-redshift quasars as compared with the corresponding singular isothermal sphere model. The finite core radius effect is about 20 percent for a lambda-dominated flat universe. It is also shown that the most recent galaxy luminosity function gives lensing probabilities that are smaller than previously estimated roughly by a factor of 3.

Gravitational lensing frequencies - Galaxy cross-sections and selection effects

NASA Technical Reports Server (NTRS)

Fukugita, Masataka; Turner, Edwin L.

1991-01-01

Four issues - (1) the best currently available data on the galaxy velocity-dispersion distribution, (2) the effects of finite core radii potential ellipticity on lensing cross sections, (3) the predicted distribution of lens image separations compared to observational angular resolutions, and (4) the preferential inclusion of lens systems in flux limited samples - are considered in order to facilitate more realistic predictions of multiple image galaxy-quasar lensing frequencies. It is found that (1) the SIS lensing parameter F equals 0.047 +/-0.019 with almost 90 percent contributed by E and S0 galaxies, (2) observed E and S0 core radii are remarkably small, yielding a factor of less than about 2 reduction in total lensing cross sections, (3) 50 percent of galaxy-quasar lenses have image separations greater than about 1.3 arcsec, and (4) amplification bias factors are large and must be carefully taken into account. It is concluded that flat universe models excessively dominated by the cosmological constant are not favored by the small observed galaxy-quasar lensing rate.

Effect of Masked Regions on Weak-lensing Statistics

NASA Astrophysics Data System (ADS)

Shirasaki, Masato; Yoshida, Naoki; Hamana, Takashi

2013-09-01

Sky masking is unavoidable in wide-field weak-lensing observations. We study how masks affect the measurement of statistics of matter distribution probed by weak gravitational lensing. We first use 1000 cosmological ray-tracing simulations to examine in detail the impact of masked regions on the weak-lensing Minkowski Functionals (MFs). We consider actual sky masks used for a Subaru Suprime-Cam imaging survey. The masks increase the variance of the convergence field and the expected values of the MFs are biased. The bias then compromises the non-Gaussian signals induced by the gravitational growth of structure. We then explore how masks affect cosmological parameter estimation. We calculate the cumulative signal-to-noise ratio (S/N) for masked maps to study the information content of lensing MFs. We show that the degradation of S/N for masked maps is mainly determined by the effective survey area. We also perform simple χ2 analysis to show the impact of lensing MF bias due to masked regions. Finally, we compare ray-tracing simulations with data from a Subaru 2 deg2 survey in order to address if the observed lensing MFs are consistent with those of the standard cosmology. The resulting χ2/n dof = 29.6/30 for three combined MFs, obtained with the mask effects taken into account, suggests that the observational data are indeed consistent with the standard ΛCDM model. We conclude that the lensing MFs are a powerful probe of cosmology only if mask effects are correctly taken into account.

Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing

DOE PAGES

Terwilliger, Thomas C.; Bunkóczi, Gábor; Hung, Li-Wei; ...

2016-03-01

A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. We present a simple theoretical framework for describing measurements of anomalous differences and the resulting useful anomalous correlation and anomalous signal in a SAD experiment. Here, the useful anomalous correlation is defined as the correlation of anomalous differences with ideal anomalous differences from the anomalous substructure. The useful anomalous correlation reflects the accuracy of the data and the absence of minor sites. The useful anomalous correlation also reflects the information available for estimating crystallographic phases once the substructure has been determined.more » In contrast, the anomalous signal (the peak height in a model-phased anomalous difference Fourier at the coordinates of atoms in the anomalous substructure) reflects the information available about each site in the substructure and is related to the ability to find the substructure. A theoretical analysis shows that the expected value of the anomalous signal is the product of the useful anomalous correlation, the square root of the ratio of the number of unique reflections in the data set to the number of sites in the substructure, and a function that decreases with increasing values of the atomic displacement factor for the atoms in the substructure. In conclusion, this means that the ability to find the substructure in a SAD experiment is increased by high data quality and by a high ratio of reflections to sites in the substructure, and is decreased by high atomic displacement factors for the substructure.« less

Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing.

PubMed

Terwilliger, Thomas C; Bunkóczi, Gábor; Hung, Li Wei; Zwart, Peter H; Smith, Janet L; Akey, David L; Adams, Paul D

2016-03-01

A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. A simple theoretical framework for describing measurements of anomalous differences and the resulting useful anomalous correlation and anomalous signal in a SAD experiment is presented. Here, the useful anomalous correlation is defined as the correlation of anomalous differences with ideal anomalous differences from the anomalous substructure. The useful anomalous correlation reflects the accuracy of the data and the absence of minor sites. The useful anomalous correlation also reflects the information available for estimating crystallographic phases once the substructure has been determined. In contrast, the anomalous signal (the peak height in a model-phased anomalous difference Fourier at the coordinates of atoms in the anomalous substructure) reflects the information available about each site in the substructure and is related to the ability to find the substructure. A theoretical analysis shows that the expected value of the anomalous signal is the product of the useful anomalous correlation, the square root of the ratio of the number of unique reflections in the data set to the number of sites in the substructure, and a function that decreases with increasing values of the atomic displacement factor for the atoms in the substructure. This means that the ability to find the substructure in a SAD experiment is increased by high data quality and by a high ratio of reflections to sites in the substructure, and is decreased by high atomic displacement factors for the substructure.

Dense arrays of millimeter-sized glass lenses fabricated at wafer-level.

PubMed

Albero, Jorge; Perrin, Stéphane; Bargiel, Sylwester; Passilly, Nicolas; Baranski, Maciej; Gauthier-Manuel, Ludovic; Bernard, Florent; Lullin, Justine; Froehly, Luc; Krauter, Johann; Osten, Wolfgang; Gorecki, Christophe

2015-05-04

This paper presents the study of a fabrication technique of lenses arrays based on the reflow of glass inside cylindrical silicon cavities. Lenses whose sizes are out of the microfabrication standards are considered. In particular, the case of high fill factor arrays is discussed in detail since the proximity between lenses generates undesired effects. These effects, not experienced when lenses are sufficiently separated so that they can be considered as single items, are corrected by properly designing the silicon cavities. Complete topographic as well as optical characterizations are reported. The compatibility of materials with Micro-Opto-Electromechanical Systems (MOEMS) integration processes makes this technology attractive for the miniaturization of inspection systems, especially those devoted to imaging.

Distant Galactic Halo Substructures Observed by the Palomar Transient Factory

NASA Astrophysics Data System (ADS)

Sesar, Branimir

2013-01-01

Characterization of Galactic halo substructures is important as their kinematic and chemical properties help constrain the properties of the Galactic dark matter halo, the formation history of the Milky Way, and the galaxy formation process in general. The best practical choice for finding distant halo substructures are pulsating RR Lyrae stars, due to their intrinsic brightness (M_V = 0.6 mag) and distinct light curves. I will present kinematic and chemical properties of two distant halo substructures that were traced using RR Lyrae stars observed by the Palomar Transient Factory. One of these substructures, located at 90 kpc from the Sun in the Cancer constellation, consists of two groups of RR Lyrae stars moving away from the Galaxy at ~80 and ~20 km/s, respectively. The second substructure is located at ~65 kpc from the Sun in the Hercules constellation. The kinematics of RR Lyrae stars tracing this substructure suggest a presence of 2 or 3 stellar streams extending in the similar direction on the sky. Due to their spatial extent, both of these substructures are clearly disrupted and would be very difficult to detect using tradiitonal techniques such as the color-magnitude diagram filtering.

Theoretical and software considerations for general dynamic analysis using multilevel substructured models

NASA Technical Reports Server (NTRS)

Schmidt, R. J.; Dodds, R. H., Jr.

1985-01-01

The dynamic analysis of complex structural systems using the finite element method and multilevel substructured models is presented. The fixed-interface method is selected for substructure reduction because of its efficiency, accuracy, and adaptability to restart and reanalysis. This method is extended to reduction of substructures which are themselves composed of reduced substructures. The implementation and performance of the method in a general purpose software system is emphasized. Solution algorithms consistent with the chosen data structures are presented. It is demonstrated that successful finite element software requires the use of software executives to supplement the algorithmic language. The complexity of the implementation of restart and reanalysis porcedures illustrates the need for executive systems to support the noncomputational aspects of the software. It is shown that significant computational efficiencies can be achieved through proper use of substructuring and reduction technbiques without sacrificing solution accuracy. The restart and reanalysis capabilities and the flexible procedures for multilevel substructured modeling gives economical yet accurate analyses of complex structural systems.

A structural design decomposition method utilizing substructuring

NASA Technical Reports Server (NTRS)

Scotti, Stephen J.

1994-01-01

A new method of design decomposition for structural analysis and optimization is described. For this method, the structure is divided into substructures where each substructure has its structural response described by a structural-response subproblem, and its structural sizing determined from a structural-sizing subproblem. The structural responses of substructures that have rigid body modes when separated from the remainder of the structure are further decomposed into displacements that have no rigid body components, and a set of rigid body modes. The structural-response subproblems are linked together through forces determined within a structural-sizing coordination subproblem which also determines the magnitude of any rigid body displacements. Structural-sizing subproblems having constraints local to the substructures are linked together through penalty terms that are determined by a structural-sizing coordination subproblem. All the substructure structural-response subproblems are totally decoupled from each other, as are all the substructure structural-sizing subproblems, thus there is significant potential for use of parallel solution methods for these subproblems.

Analysis and Application of European Genetic Substructure Using 300 K SNP Information

PubMed Central

Tian, Chao; Plenge, Robert M; Ransom, Michael; Lee, Annette; Villoslada, Pablo; Selmi, Carlo; Klareskog, Lars; Pulver, Ann E; Qi, Lihong; Gregersen, Peter K; Seldin, Michael F

2008-01-01

European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal component (PC) differentiated northern from southern European ancestry. A second PC further separated Italian, Spanish, and Greek individuals from those of Ashkenazi Jewish ancestry as well as distinguishing among northern European populations. In separate analyses of northern European participants other substructure relationships were discerned showing a west to east gradient. Application of this substructure information was critical in examining a real dataset in whole genome association (WGA) analyses for rheumatoid arthritis in European Americans to reduce false positive signals. In addition, two sets of European substructure ancestry informative markers (ESAIMs) were identified that provide substantial substructure information. The results provide further insight into European population genetic substructure and show that this information can be used for improving error rates in association testing of candidate genes and in replication studies of WGA scans. PMID:18208329

Lensing as a probe of early universe: from CMB to galaxies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hassani, Farbod; Baghram, Shant; Firouzjahi, Hassan, E-mail: farbod@physics.sharif.edu, E-mail: baghram@sharif.edu, E-mail: firouz@ipm.ir

The Cosmic Microwave Background (CMB) radiation lensing is a promising tool to study the physics of early universe. In this work we probe the imprints of deviations from isotropy and scale invariance of primordial curvature perturbation power spectrum on CMB lensing potential and convergence. Specifically, we consider a scale-dependent hemispherical asymmetry in primordial power spectrum. We show that the CMB lensing potential and convergence and also the cross-correlation of the CMB lensing and late time galaxy convergence can probe the amplitude and the scale dependence of the dipole modulation. As another example, we consider a primordial power spectrum with localmore » feature. We show that the CMB lensing and the cross-correlation of the CMB lensing and galaxy lensing can probe the amplitude and the shape of the local feature. We show that the cross correlation of CMB lensing convergence and galaxy lensing is capable to probe the effects of local features in power spectrum on smaller scales than the CMB lensing. Finally we showed that the current data can constrain the amplitude and moment dependence of dipole asymmetry.« less

Evaporation of a Volatile Liquid Lens on the Surface of an Immiscible Liquid.

PubMed

Sun, Wei; Yang, Fuqian

2016-06-21

The evaporation behavior of toluene and hexane lenses on the surface of deionized (DI) water is studied. The toluene and hexane lenses during evaporation experience an advancing stage and a receding stage. There exists a significant difference of the evaporation behavior between the toluene lenses and the hexane lenses. The lifetime and largest diameter of both the toluene and hexane lenses increase with increasing the initial volume of the lenses. For the evaporation of the toluene lenses, the lifetime and largest diameter of the lenses decrease with increasing the temperature of DI water. The effect of the residual of the oil molecules on the evaporation of toluene lenses at a temperature of 21 °C is investigated via the evaporation of a series of consecutive toluene lenses being placed on the same position of the surface of DI water. The temporal evolution of the toluene lenses placed after the first toluene lens deviates significantly from that of the first toluene lens. Significant increase of the receding speed occurs at the dimensionless time in a range 0.7-0.8.

Convolved substructure: analytically decorrelating jet substructure observables

NASA Astrophysics Data System (ADS)

Moult, Ian; Nachman, Benjamin; Neill, Duff

2018-05-01

A number of recent applications of jet substructure, in particular searches for light new particles, require substructure observables that are decorrelated with the jet mass. In this paper we introduce the Convolved SubStructure (CSS) approach, which uses a theoretical understanding of the observable to decorrelate the complete shape of its distribution. This decorrelation is performed by convolution with a shape function whose parameters and mass dependence are derived analytically. We consider in detail the case of the D 2 observable and perform an illustrative case study using a search for a light hadronically decaying Z'. We find that the CSS approach completely decorrelates the D 2 observable over a wide range of masses. Our approach highlights the importance of improving the theoretical understanding of jet substructure observables to exploit increasingly subtle features for performance.

Efficient heuristics for maximum common substructure search.

PubMed

Englert, Péter; Kovács, Péter

2015-05-26

Maximum common substructure search is a computationally hard optimization problem with diverse applications in the field of cheminformatics, including similarity search, lead optimization, molecule alignment, and clustering. Most of these applications have strict constraints on running time, so heuristic methods are often preferred. However, the development of an algorithm that is both fast enough and accurate enough for most practical purposes is still a challenge. Moreover, in some applications, the quality of a common substructure depends not only on its size but also on various topological features of the one-to-one atom correspondence it defines. Two state-of-the-art heuristic algorithms for finding maximum common substructures have been implemented at ChemAxon Ltd., and effective heuristics have been developed to improve both their efficiency and the relevance of the atom mappings they provide. The implementations have been thoroughly evaluated and compared with existing solutions (KCOMBU and Indigo). The heuristics have been found to greatly improve the performance and applicability of the algorithms. The purpose of this paper is to introduce the applied methods and present the experimental results.

Effect of surfactant chain length on drug release kinetics from microemulsion-laden contact lenses.

PubMed

Maulvi, Furqan A; Desai, Ankita R; Choksi, Harsh H; Patil, Rahul J; Ranch, Ketan M; Vyas, Bhavin A; Shah, Dinesh O

2017-05-30

The effect of surfactant chain lengths [sodium caprylate (C 8 ), Tween 20 (C 12 ), Tween 80 (C 18 )] and the molecular weight of block copolymers [Pluronic F68 and Pluronic F 127] were studied to determine the stability of the microemulsion and its effect on release kinetics from cyclosporine-loaded microemulsion-laden hydrogel contact lenses in this work. Globule size and dilution tests (transmittance) suggested that the stability of the microemulsion increases with increase in the carbon chain lengths of surfactants and the molecular weight of pluronics. The optical transmittance of direct drug-laden contact lenses [DL-100] was low due to the precipitation of hydrophobic drugs in the lenses, while in microemulsion-laden lenses, the transmittance was improved when stability of the microemulsion was achieved. The results of in vitro release kinetics revealed that drug release was sustained to a greater extent as the stability of microemulsion was improved as well. This was evident in batch PF127-T80, which showed sustained release for 15days in comparison to batch DL-100, which showed release up to 7days. An in vivo drug release study in rabbit tear fluid showed significant increase in mean residence time (MRT) and area under curve (AUC) with PF-127-T80 lenses (stable microemulsion) in comparison to PF-68-SC lenses (unstable microemulsion) and DL-100 lenses. This study revealed the correlation between the stability of microemulsion and the release kinetics of drugs from contact lenses. Thus, it was inferred that the stable microemulsion batches sustained the release of hydrophobic drugs, such as cyclosporine from contact lenses for an extended period of time without altering critical lens properties. Copyright © 2017 Elsevier B.V. All rights reserved.

Automated deconvolution of structured mixtures from heterogeneous tumor genomic data

PubMed Central

Roman, Theodore; Xie, Lu

2017-01-01

With increasing appreciation for the extent and importance of intratumor heterogeneity, much attention in cancer research has focused on profiling heterogeneity on a single patient level. Although true single-cell genomic technologies are rapidly improving, they remain too noisy and costly at present for population-level studies. Bulk sequencing remains the standard for population-scale tumor genomics, creating a need for computational tools to separate contributions of multiple tumor clones and assorted stromal and infiltrating cell populations to pooled genomic data. All such methods are limited to coarse approximations of only a few cell subpopulations, however. In prior work, we demonstrated the feasibility of improving cell type deconvolution by taking advantage of substructure in genomic mixtures via a strategy called simplicial complex unmixing. We improve on past work by introducing enhancements to automate learning of substructured genomic mixtures, with specific emphasis on genome-wide copy number variation (CNV) data, as well as the ability to process quantitative RNA expression data, and heterogeneous combinations of RNA and CNV data. We introduce methods for dimensionality estimation to better decompose mixture model substructure; fuzzy clustering to better identify substructure in sparse, noisy data; and automated model inference methods for other key model parameters. We further demonstrate their effectiveness in identifying mixture substructure in true breast cancer CNV data from the Cancer Genome Atlas (TCGA). Source code is available at https://github.com/tedroman/WSCUnmix PMID:29059177

On the use of attachment modes in substructure coupling for dynamic analysis

NASA Technical Reports Server (NTRS)

Craig, R. R., Jr.; Chang, C.-J.

1977-01-01

Substructure coupling or component-mode synthesis may be employed in the solution of dynamics problems for complex structures. Although numerous substructure-coupling methods have been devised, little attention has been devoted to methods employing attachment modes. In the present paper the various mode sets (normal modes, constraint modes, attachment modes) are defined. A generalized substructure-coupling procedure is described. Those substructure-coupling methods which employ attachment modes are described in detail. One of these methods is shown to lead to results (e.g., system natural frequencies) comparable to or better than those obtained by the Hurty (1965) method.

Lensing effects in a nematic liquid crystal with topological defects.

PubMed

Sátiro, C; Moraes, F

2006-06-01

Light traveling through a liquid crystal with disclinations perceives a geometrical background which causes lensing effects similar to the ones predicted for cosmic objects like global monopoles and cosmic strings. In this paper we explore the effective geometry as perceived by light in such media. The comparison between both systems suggests that experiments can be done in the laboratory to simulate optical properties, like gravitational lensing, of cosmic objects.

Acta Aeronautica et Astronautica Sinica,

DTIC Science & Technology

1983-07-28

substructural analysis in modal synthesis - two improved substructural assembling techniques 49 9-node quadrilateral isoparametric element 64 Application of laser...Time from Service Data, J. Aircraft, Vol. 15, No. 11, 1978. 48 MULTI-LEVEL SUBSTRUCTURAL ANALYSIS IN MODAL SYNTHESIS -- TWO IMPROVED SUBSTRUCTURAL...34 Modal Synthesis in Structural Dynamic Analysis ," Naching Institute of Aeronautics and Astronautics, 1979. 62a 8. Chang Te-wen, "Free-Interface Modal

Strong Gravitational Lensing: Relativity in Action

NASA Astrophysics Data System (ADS)

Wambsganss, Joachim

2009-05-01

Deflection of light by gravity was predicted by Einstein's Theory of General Relativity and observationally confirmed in 1919. In the following decades, various aspects of the gravitational lens effect were explored theoretically, among them measuring the Hubble constant from multiple images of a background source, making use of the magnifying effect as a gravitational telescope, or the possibility of a "relativistic eclipse" as a perfect test of GR. Only in 1979, gravitational lensing became an observational science when the first doubly imaged quasar was discovered. Today lensing is a booming part of astrophysics and cosmology. A whole suite of strong lensing phenomena have been investigated since: multiple quasars, giant luminous arcs, Einstein rings, quasar microlensing, and galactic microlensing. The most recent lensing application is the detection of extrasolar planets. Lensing has contributed significant new results in areas as different as the cosmological distance scale, mass determination of galaxy clusters, physics of quasars, searches for dark matter in galaxy halos, structure of the Milky Way, stellar atmospheres and exoplanets. A guided tour through some of these applications -- with both photometric and astrometric signatures of lensing being discussed -- will illustrate how gravitational lensing has established itself as a very useful universal astrophysical tool.

Groomed jets in heavy-ion collisions: sensitivity to medium-induced bremsstrahlung

NASA Astrophysics Data System (ADS)

Mehtar-Tani, Yacine; Tywoniuk, Konrad

2017-04-01

We argue that contemporary jet substructure techniques might facilitate a more direct measurement of hard medium-induced gluon bremsstrahlung in heavy-ion collisions, and focus specifically on the "soft drop declustering" procedure that singles out the two leading jet substructures. Assuming coherent jet energy loss, we find an enhancement of the distribution of the energy fractions shared by the two substructures at small subjet energy caused by hard medium-induced gluon radiation. Departures from this approximation are discussed, in particular, the effects of colour decoherence and the contamination of the grooming procedure by soft background. Finally, we propose a complementary observable, that is the ratio of the two-pronged probability in Pb-Pb to proton-proton collisions and discuss its sensitivity to various energy loss mechanisms.

Effects of lenses with different power profiles on eye shape in chickens.

PubMed

Tepelus, Tudor Cosmin; Vazquez, Daniel; Seidemann, Anne; Uttenweiler, Dietmar; Schaeffel, Frank

2012-02-01

Defocus imposed to the periphery of the visual field can affect the development of foveal/central refractive errors. To make use of this observation, lenses can be designed to reduce myopia progression, but it is important to know which power profiles of the lenses are most effective. We have studied this question in chickens. Sixty male white leghorn chickens were used. From day 7 after hatching, they were treated for 5 days either with full field -7D or +7D lenses, with -7D lenses with a 4mm central hole, with hemi-field lenses of the same power, or with two different types of radial refractive gradient (RRG) lenses with increasing positive power from the center to the periphery, which were designed by Rodenstock GmbH, Munich, Germany. A macro file was written for "ImageJ" to trace and average the outlines of several excised eyes after treatment. Shapes of fellow control eyes and lens-treated eyes were compared in the horizontal and vertical meridians. Refractions were determined at -45°, 0°, and 45° over the horizontal visual field, at the beginning and at the end of experiments, using automated infrared photoretinoscopy. (1) Eye length, as determined by the new automated eye shape tracing technique, was well correlated with A-scan ultrasound data. (2) The effects of previously tested lens designs were reproduced with the new tracing technique. Full field lenses were by far the most effective (-7D: external axial length +0.24mm with an increase in eye volume of about 6%, +7D: -0.08 mm, with a decrease in eye volume of about 2%). Hemi-field lenses and negative lenses with a 4mm central hole induced conspicuous local changes in eye shape. (3) The first type of RRG lenses with a plano zone of about 4mm (equivalent to about ± 12.52° in the visual field for a vertex distance of 5mm) had no apparent effect on central refractions but induced small hyperopic shifts in the periphery, more significant in the temporal retina (+1.70 ± 1.70 D, p<0.001, paired t-test to untreated fellow eyes). The second type of RRG lenses with a small plano zone of 2mm (equivalent to ± 6.34°) induced peripheral hyperopia but also changed the central refraction (temporal retina +1.50 ± 1.17D, p<0.001, central retina +0.77 ± 1.15 D, p<0.01, nasal retina +1.47±1.35D, p<0.001, paired t-test to untreated control eyes). In the afoveate chick, RRG lenses have an effect on central refraction and eye growth only if the central plano zone is small (<4mm). For the second type of RRG lens with a central plano zone of about 2mm, inhibitory effects on eye growth were detected in both the center and periphery even though the optical power of the lenses in the periphery was low. Copyright © 2011 Elsevier Ltd. All rights reserved.

Bacterial adhesion to unworn and worn silicone hydrogel lenses.

PubMed

Vijay, Ajay Kumar; Zhu, Hua; Ozkan, Jerome; Wu, Duojia; Masoudi, Simin; Bandara, Rani; Borazjani, Roya N; Willcox, Mark D P

2012-08-01

The objective of this study was to determine the bacterial adhesion to various silicone hydrogel lens materials and to determine whether lens wear modulated adhesion. Bacterial adhesion (total and viable cells) of Staphylococcus aureus (31, 38, and ATCC 6538) and Pseudomonas aeruginosa (6294, 6206, and GSU-3) to 10 commercially available different unworn and worn silicone hydrogel lenses was measured. Results of adhesion were correlated to polymer and surface properties of contact lenses. S. aureus adhesion to unworn lenses ranged from 2.8 × 10 to 4.4 × 10 colony forming units per lens. The highest adhesion was to lotrafilcon A lenses, and the lowest adhesion was to asmofilcon A lenses. P. aeruginosa adhesion to unworn lenses ranged from 8.9 × 10 to 3.2 × 10 colony forming units per lens. The highest adhesion was to comfilcon A lenses, and the lowest adhesion was to asmofilcon A and balafilcon A lenses. Lens wear altered bacterial adhesion, but the effect was specific to lens and strain type. Adhesion of bacteria, regardless of genera/species or lens wear, was generally correlated with the hydrophobicity of the lens; the less hydrophobic the lens surface, the greater the adhesion. P. aeruginosa adhered in higher numbers to lenses in comparison with S. aureus strains, regardless of the lens type or lens wear. The effect of lens wear was specific to strain and lens. Hydrophobicity of the silicone hydrogel lens surface influenced the adhesion of bacterial cells.

Fimbrolide-coated antimicrobial lenses: their in vitro and in vivo effects.

PubMed

Zhu, Hua; Kumar, Ajay; Ozkan, Jerome; Bandara, Rani; Ding, Aidong; Perera, Indrani; Steinberg, Peter; Kumar, Naresh; Lao, William; Griesser, Stefani S; Britcher, Leanne; Griesser, Hans J; Willcox, Mark D P

2008-05-01

To examine the ability of contact lenses coated with fimbrolides, inhibitors of bacterial quorum sensing, to prevent microbial adhesion and their safety during short-term clinical assessment. A fimbrolide was covalently attached to commercially available high Dk contact lenses. Subsequently Pseudomonas aeruginosa, Staphylococcus aureus, Serratia marcescens, or Acanthamoeba sp. were added to the lenses and control uncoated contact lenses. Lenses plus microbes were incubated for 24 h, then washed thoroughly to remove non-adherent microbes. Lenses were macerated and resulting slurry plated onto agar plates. After appropriate incubation, the numbers of colony forming units of bacteria (or numbers of Acanthamoeba trophozoites measured using a hemocytometer) from fimbrolide-coated and uncoated lenses were examined. A Guinea Pig model of lens wear was used to assess the safety of lenses worn on a continuous basis for 1 month. In a separate study, 10 subjects wore fimbrolide-coated lenses for 24 h. The responses of the Guinea Pigs and human volunteers to the lenses were assessed by slit lamp examination. The fimbrolides-coated lenses reduced the adhesion of all bacterial strains tested, with reductions occurring of between 67 and 92%. For Acanthamoeba a reduction of 70% was seen. There were no significant differences in ocular responses to fimbrolide-coated lenses compared with controls in either the 1 month animal model or overnight human trial. Fimbrolide-coated lenses show promise as an antibacterial and anti-acanthamoebal coating on contact lenses and appear to be safe when worn on the eye in an animal model.

The effects of contact lens materials on a multipurpose contact lens solution disinfection activity against Staphylococcus aureus.

PubMed

Shoff, Megan E; Lucas, Anne D; Brown, Jennifer N; Hitchins, Victoria M; Eydelman, Malvina B

2012-11-01

To determine the effect of 8 different lens materials on polyhexamethylene biguanide (PHMB) concentration in multipurpose solution (MPS) levels over time and to determine the effect of lenses on lens solution microbial efficacy over time. Silicone hydrogel lenses and conventional hydrogel lenses were soaked in polypropylene lens cases filled with contact lens MPS containing 1 ppm PHMB for 6, 12, 24, 72, and 168 hours. Cases filled with the same solution without lenses were controls. After each time period, solutions from cases with the 8 types of lenses and controls were assayed for activity against Staphylococcus aureus according to International Organization for Standardization-14729 with modifications. Solutions were analyzed for PHMB concentration at each time point. Some of the different lens materials significantly affected the PHMB concentration (P<0.0001) and the biocidal efficacy. Etafilcon A lenses significantly decreased PHMB levels after only 6 hours of lens soak time. The product lot of MPS used was also significant (P<0.0001). Enfilcon A, senofilcon A, and lotrafilcon B lenses did not significantly decrease PHMB levels. The efficacy of MPS was affected by some lens materials and PHMB concentration. Lens materials differ in their effect on PHMB concentration and the subsequent efficacy of the MPS. Over time, some lens materials can significantly reduce the PHMB concentration and the MPS's microbial activity against S. aureus.

On Using a Space Telescope to Detect Weak-lensing Shear

NASA Astrophysics Data System (ADS)

Tung, Nathan; Wright, Edward

2017-11-01

Ignoring redshift dependence, the statistical performance of a weak-lensing survey is set by two numbers: the effective shape noise of the sources, which includes the intrinsic ellipticity dispersion and the measurement noise, and the density of sources that are useful for weak-lensing measurements. In this paper, we provide some general guidance for weak-lensing shear measurements from a “generic” space telescope by looking for the optimum wavelength bands to maximize the galaxy flux signal-to-noise ratio (S/N) and minimize ellipticity measurement error. We also calculate an effective galaxy number per square degree across different wavelength bands, taking into account the density of sources that are useful for weak-lensing measurements and the effective shape noise of sources. Galaxy data collected from the ultra-deep UltraVISTA Ks-selected and R-selected photometric catalogs (Muzzin et al. 2013) are fitted to radially symmetric Sérsic galaxy light profiles. The Sérsic galaxy profiles are then stretched to impose an artificial weak-lensing shear, and then convolved with a pure Airy Disk PSF to simulate imaging of weak gravitationally lensed galaxies from a hypothetical diffraction-limited space telescope. For our model calculations and sets of galaxies, our results show that the peak in the average galaxy flux S/N, the minimum average ellipticity measurement error, and the highest effective galaxy number counts all lie around the K-band near 2.2 μm.

Lensing is low: cosmology, galaxy formation or new physics?

NASA Astrophysics Data System (ADS)

Leauthaud, Alexie; Saito, Shun; Hilbert, Stefan; Barreira, Alexandre; More, Surhud; White, Martin; Alam, Shadab; Behroozi, Peter; Bundy, Kevin; Coupon, Jean; Erben, Thomas; Heymans, Catherine; Hildebrandt, Hendrik; Mandelbaum, Rachel; Miller, Lance; Moraes, Bruno; Pereira, Maria E. S.; Rodríguez-Torres, Sergio A.; Schmidt, Fabian; Shan, Huan-Yuan; Viel, Matteo; Villaescusa-Navarro, Francisco

2017-05-01

We present high signal-to-noise galaxy-galaxy lensing measurements of the Baryon Oscillation Spectroscopic Survey constant mass (CMASS) sample using 250 deg2 of weak-lensing data from Canada-France-Hawaii Telescope Lensing Survey and Canada-France-Hawaii Telescope Stripe 82 Survey. We compare this signal with predictions from mock catalogues trained to match observables including the stellar mass function and the projected and two-dimensional clustering of CMASS. We show that the clustering of CMASS, together with standard models of the galaxy-halo connection, robustly predicts a lensing signal that is 20-40 per cent larger than observed. Detailed tests show that our results are robust to a variety of systematic effects. Lowering the value of S_8=σ _8 \\sqrt{Ω _m/0.3} compared to Planck Collaboration XIII reconciles the lensing with clustering. However, given the scale of our measurement (r < 10 h-1 Mpc), other effects may also be at play and need to be taken into consideration. We explore the impact of baryon physics, assembly bias, massive neutrinos and modifications to general relativity on ΔΣ and show that several of these effects may be non-negligible given the precision of our measurement. Disentangling cosmological effects from the details of the galaxy-halo connection, the effect of baryons, and massive neutrinos, is the next challenge facing joint lensing and clustering analyses. This is especially true in the context of large galaxy samples from Baryon Acoustic Oscillation surveys with precise measurements but complex selection functions.

EFFECT OF MASKED REGIONS ON WEAK-LENSING STATISTICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shirasaki, Masato; Yoshida, Naoki; Hamana, Takashi, E-mail: masato.shirasaki@utap.phys.s.u-tokyo.ac.jp

2013-09-10

Sky masking is unavoidable in wide-field weak-lensing observations. We study how masks affect the measurement of statistics of matter distribution probed by weak gravitational lensing. We first use 1000 cosmological ray-tracing simulations to examine in detail the impact of masked regions on the weak-lensing Minkowski Functionals (MFs). We consider actual sky masks used for a Subaru Suprime-Cam imaging survey. The masks increase the variance of the convergence field and the expected values of the MFs are biased. The bias then compromises the non-Gaussian signals induced by the gravitational growth of structure. We then explore how masks affect cosmological parameter estimation.more » We calculate the cumulative signal-to-noise ratio (S/N) for masked maps to study the information content of lensing MFs. We show that the degradation of S/N for masked maps is mainly determined by the effective survey area. We also perform simple {chi}{sup 2} analysis to show the impact of lensing MF bias due to masked regions. Finally, we compare ray-tracing simulations with data from a Subaru 2 deg{sup 2} survey in order to address if the observed lensing MFs are consistent with those of the standard cosmology. The resulting {chi}{sup 2}/n{sub dof} = 29.6/30 for three combined MFs, obtained with the mask effects taken into account, suggests that the observational data are indeed consistent with the standard {Lambda}CDM model. We conclude that the lensing MFs are a powerful probe of cosmology only if mask effects are correctly taken into account.« less

DETECTION OF A COMPANION LENS GALAXY USING THE MID-INFRARED FLUX RATIOS OF THE GRAVITATIONALLY LENSED QUASAR H1413+117

DOE Office of Scientific and Technical Information (OSTI.GOV)

MacLeod, Chelsea L.; Agol, Eric; Kochanek, Christopher S.

2009-07-10

We present the first resolved mid-infrared (IR) (11 {mu}m) observations of the four-image quasar lens H1413+117 using the Michelle camera on Gemini North. All previous observations (optical, near-IR, and radio) of this lens show a 'flux anomaly', where the image flux ratios cannot be explained by a simple, central lens galaxy. We attempt to reproduce the mid-IR flux ratios, which are insensitive to extinction and microlensing, by modeling the main lens as a singular isothermal ellipsoid. This model fails to reproduce the flux ratios. However, we can explain the flux ratios simply by adding to the model a nearby galaxymore » detected in the H band by the Hubble Space Telescope. This perturbing galaxy lies 4.''0 from the main lens and it has a critical radius of 0.''63 {+-} 0.''02 which is similar to that of the main lens, as expected from their similar H-band fluxes. More remarkably, this galaxy is not required to obtain a good fit to the system astrometry, so this represents the first clear detection of an object through its effect on the image fluxes of a gravitational lens. This is a parallel to the detections of visible satellites from astrometric anomalies, and provides a proof of the concept of searching for substructure in galaxies using anomalous flux ratios.« less

Dynamic bridge substructure evaluation and monitoring

DOT National Transportation Integrated Search

2005-09-01

This research project was funded to investigate the possibility that, by measuring and modeling the dynamic response characteristics of a bridge substructure, it might be possible to determine the condition and safety of the substructure and identify...

CMB-lensing beyond the Born approximation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marozzi, Giovanni; Fanizza, Giuseppe; Durrer, Ruth

2016-09-01

We investigate the weak lensing corrections to the cosmic microwave background temperature anisotropies considering effects beyond the Born approximation. To this aim, we use the small deflection angle approximation, to connect the lensed and unlensed power spectra, via expressions for the deflection angles up to third order in the gravitational potential. While the small deflection angle approximation has the drawback to be reliable only for multipoles ℓ ∼< 2500, it allows us to consistently take into account the non-Gaussian nature of cosmological perturbation theory beyond the linear level. The contribution to the lensed temperature power spectrum coming from the non-Gaussianmore » nature of the deflection angle at higher order is a new effect which has not been taken into account in the literature so far. It turns out to be the leading contribution among the post-Born lensing corrections. On the other hand, the effect is smaller than corrections coming from non-linearities in the matter power spectrum, and its imprint on CMB lensing is too small to be seen in present experiments.« less

Strong gravitational lensing: relativity in action

NASA Astrophysics Data System (ADS)

Wambsganss, Joachim

2010-01-01

Deflection of light by gravity was predicted by Einstein's Theory of General Relativity and observationally confirmed in 1919. In the following decades, various aspects of the gravitational lens effect were explored theoretically, among them measuring the Hubble constant from multiple images of a background source, making use of the magnifying effect as a gravitational telescope, or the possibility of a “relativistic eclipse” as a perfect test of GR. Only in 1979, gravitational lensing became an observational science when the first doubly imaged quasar was discovered. Today lensing is a booming part of astrophysics and cosmology. A whole suite of strong lensing phenomena have been investigated: multiple quasars, giant luminous arcs, Einstein rings, quasar microlensing, and galactic microlensing. The most recent lensing application is the detection of extrasolar planets. Lensing has contributed significant new results in areas as different as the cosmological distance scale, mass determination of galaxy clusters, physics of quasars, searches for dark matter in galaxy halos, structure of the Milky Way, stellar atmospheres and exoplanets. A guided tour through some of these applications will illustrate how gravitational lensing has established itself as a very useful universal astrophysical tool.

Decentralized control of large flexible structures by joint decoupling

NASA Technical Reports Server (NTRS)

Su, Tzu-Jeng; Juang, Jer-Nan

1992-01-01

A decentralized control design method is presented for large complex flexible structures by using the idea of joint decoupling. The derivation is based on a coupled substructure state-space model, which is obtained from enforcing conditions of interface compatibility and equilibrium to the substructure state-space models. It is shown that by restricting the control law to be localized state feedback and by setting the joint actuator input commands to decouple joint 'degrees of freedom' (dof) from interior dof, the global structure control design problem can be decomposed into several substructure control design problems. The substructure control gains and substructure observers are designed based on modified substructure state-space models. The controllers produced by the proposed method can operate successfully at the individual substructure level as well as at the global structure level. Therefore, not only control design but also control implementation is decentralized. Stability and performance requirement of the closed-loop system can be achieved by using any existing state feedback control design method. A two-component mass-spring damper system and a three-truss structure are used as examples to demonstrate the proposed method.

Gauge-invariant formalism of cosmological weak lensing

NASA Astrophysics Data System (ADS)

Yoo, Jaiyul; Grimm, Nastassia; Mitsou, Ermis; Amara, Adam; Refregier, Alexandre

2018-04-01

We present the gauge-invariant formalism of cosmological weak lensing, accounting for all the relativistic effects due to the scalar, vector, and tensor perturbations at the linear order. While the light propagation is fully described by the geodesic equation, the relation of the photon wavevector to the physical quantities requires the specification of the frames, where they are defined. By constructing the local tetrad bases at the observer and the source positions, we clarify the relation of the weak lensing observables such as the convergence, the shear, and the rotation to the physical size and shape defined in the source rest-frame and the observed angle and redshift measured in the observer rest-frame. Compared to the standard lensing formalism, additional relativistic effects contribute to all the lensing observables. We explicitly verify the gauge-invariance of the lensing observables and compare our results to previous work. In particular, we demonstrate that even in the presence of the vector and tensor perturbations, the physical rotation of the lensing observables vanishes at the linear order, while the tetrad basis rotates along the light propagation compared to a FRW coordinate. Though the latter is often used as a probe of primordial gravitational waves, the rotation of the tetrad basis is indeed not a physical observable. We further clarify its relation to the E-B decomposition in weak lensing. Our formalism provides a transparent and comprehensive perspective of cosmological weak lensing.

Absorbance and light scattering of lenses organ cultured with glucose.

PubMed

Alghamdi, Ali Hendi Sahmi; Mohamed, Hasabelrasoul; Sledge, Samiyyah M; Borchman, Douglas

2018-06-06

Purpose/Aim: Diabetes is one of the major factors related to cataract. Our aim was to determine if the attenuation of light through glucose treated lenses was due to light scattering from structural changes or absorbance from metabolic changes. Human and rat lenses were cultured in a medium with and without 55 mM glucose for a period of five days. Absorbance and light scattering were measured using a ultraviolet spectrometer. Aldose reductase and catalase activity, RAGE, and glutathione were measured using classical assays. Almost all of the glucose related attenuation of light through the human lens was due to light scattering from structural changes. Glucose treatment caused three absorbance band to appear at 484, 540 to 644 and 657 nm in both the rat and human lens. The optimum time point for equilibration of human lenses was found to be between 2 and 3 days in organ culture. Glucose caused a more significant effect on the opacity of human lenses compared with rat lenses. Since the levels of glutathione, catalase and aldose reductase were reduced in glucose treated rat lenses compared with untreated lenses, glucose may have caused oxidative stress on the rat lens. The absorbance and light scattering of glucose treated lenses in organ culture were quantitated for the first time which could be important for future studies designed to test the efficacy of agents to ameliorate the opacity. Almost all of the glucose related attenuation of light through the human lens was due to light scattering from structural changes and not absorbance from metabolic changes. Glucose caused a more significant effect on the opacity of human lenses compared with rat lenses. The lens model employed could be used to study the efficacy of agents that potentially ameliorate lens opacity.

Objective assessment of the effect of pupil size upon the power distribution of multifocal contact lenses.

PubMed

Papadatou, Eleni; Del Águila-Carrasco, Antonio J; Esteve-Taboada, José J; Madrid-Costa, David; Cerviño-Expósito, Alejandro

2017-01-01

To analytically assess the effect of pupil size upon the refractive power distributions of different designs of multifocal contact lenses. Two multifocal contact lenses of center-near design and one multifocal contact lens of center-distance design were used in this study. Their power profiles were measured using the NIMO TR1504 device (LAMBDA-X, Belgium). Based on their power profiles, the power distribution was assessed as a function of pupil size. For the high addition lenses, the resulting refractive power as a function of viewing distance (far, intermediate, and near) and pupil size was also analyzed. The power distribution of the lenses was affected by pupil size differently. One of the lenses showed a significant spread in refractive power distribution, from about -3 D to 0 D. Generally, the power distribution of the lenses expanded as the pupil diameter became greater. The surface of the lens dedicated for each distance varied substantially with the design of the lens. In an experimental basis, our results show how the lenses power distribution is affected by the pupil size and underlined the necessity of careful evaluation of the patient's visual needs and the optical properties of a multifocal contact lens for achieving the optimal visual outcome.

Gravitational corrections to light propagation in a perturbed FLRW universe and corresponding weak-lensing spectra

NASA Astrophysics Data System (ADS)

Cuesta-Lazaro, Carolina; Quera-Bofarull, Arnau; Reischke, Robert; Schäfer, Björn Malte

2018-06-01

When the gravitational lensing of the large-scale structure is calculated from a cosmological model a few assumptions enter: (i) one assumes that the photons follow unperturbed background geodesics, which is usually referred to as the Born approximation, (ii) the lenses move slowly, (iii) the source-redshift distribution is evaluated relative to the background quantities, and (iv) the lensing effect is linear in the gravitational potential. Even though these approximations are small individually they could sum up, especially since they include local effects such as the Sachs-Wolfe and peculiar motion, but also non-local ones like the Born approximation and the integrated Sachs-Wolfe effect. In this work, we will address all points mentioned and perturbatively calculate the effect on a tomographic cosmic shear power spectrum of each effect individually as well as all cross-correlations. Our findings show that each effect is at least 4-5 orders of magnitude below the leading order lensing signal. Finally, we sum up all effects to estimate the overall impact on parameter estimation by a future cosmological weak-lensing survey such as Euclid in a wcold dark matter cosmology with parametrization Ωm, σ8, ns, h, w0, and wa, using five tomographic bins. We consistently find a parameter bias of 10-5, which is therefore completely negligible for all practical purposes, confirming that other effects such as intrinsic alignments, magnification bias and uncertainties in the redshift distribution will be the dominant systematic source in future surveys.

Groomed jets in heavy-ion collisions: sensitivity to medium-induced bremsstrahlung

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mehtar-Tani, Yacine; Tywoniuk, Konrad

Here, we argue that contemporary jet substructure techniques might facilitate a more direct measurement of hard medium-induced gluon bremsstrahlung in heavy-ion collisions, and focus specifically on the “soft drop declustering” procedure that singles out the two leading jet substructures. Assuming coherent jet energy loss, we find an enhancement of the distribution of the energy fractions shared by the two substructures at small subjet energy caused by hard medium-induced gluon radiation. Departures from this approximation are discussed, in particular, the effects of colour decoherence and the contamination of the grooming procedure by soft background. Finally, we propose a complementary observable, thatmore » is the ratio of the two-pronged probability in Pb-Pb to proton-proton collisions and discuss its sensitivity to various energy loss mechanisms.« less

Groomed jets in heavy-ion collisions: sensitivity to medium-induced bremsstrahlung

DOE PAGES

Mehtar-Tani, Yacine; Tywoniuk, Konrad

2017-04-21

Here, we argue that contemporary jet substructure techniques might facilitate a more direct measurement of hard medium-induced gluon bremsstrahlung in heavy-ion collisions, and focus specifically on the “soft drop declustering” procedure that singles out the two leading jet substructures. Assuming coherent jet energy loss, we find an enhancement of the distribution of the energy fractions shared by the two substructures at small subjet energy caused by hard medium-induced gluon radiation. Departures from this approximation are discussed, in particular, the effects of colour decoherence and the contamination of the grooming procedure by soft background. Finally, we propose a complementary observable, thatmore » is the ratio of the two-pronged probability in Pb-Pb to proton-proton collisions and discuss its sensitivity to various energy loss mechanisms.« less

A method for analyzing absorbed power distribution in the hand and arm substructures when operating vibrating tools

NASA Astrophysics Data System (ADS)

Dong, Jennie H.; Dong, Ren G.; Rakheja, Subhash; Welcome, Daniel E.; McDowell, Thomas W.; Wu, John Z.

2008-04-01

In this study it was hypothesized that the vibration-induced injuries or disorders in a substructure of human hand-arm system are primarily associated with the vibration power absorption distributed in that substructure. As the first step to test this hypothesis, the major objective of this study is to develop a method for analyzing the vibration power flow and the distribution of vibration power absorptions in the major substructures (fingers, palm-hand-wrist, forearm and upper arm, and shoulder) of the system exposed to hand-transmitted vibration. A five-degrees-of-freedom model of the system incorporating finger- as well as palm-side driving points was applied for the analysis. The mechanical impedance data measured at the two driving points under four different hand actions involving 50 N grip-only, 15 N grip and 35 N push, 30 N grip and 45 N push, and 50 N grip and 50 N push, were used to identify the model parameters. The vibration power absorption distributed in the substructures were evaluated using vibration spectra measured on many tools. The frequency weightings of the distributed vibration power absorptions were derived and compared with the weighting defined in ISO 5349-1 (2001). This study found that vibration power absorption is primarily distributed in the arm and shoulder when operating low-frequency tools such as rammers, while a high concentration of vibration power absorption in the fingers and hand is observed when operating high-frequency tools, such as grinders. The vibration power absorption distributed in palm-wrist and arm is well correlated with the ISO-weighted acceleration, while the finger vibration power absorption is highly correlated with unweighted acceleration. The finger vibration power absorption-based frequency weighting suggested that exposure to vibration in the frequency range of 16-500 Hz could pose higher risks of developing finger disorders. The results support the use of the frequency weighting specified in the current standard for assessing risks of developing disorders in the palm-wrist-arm substructures. The standardized weighting, however, could overestimate low-frequency effects but greatly underestimate high-frequency effects on the development of finger disorders. The results are further discussed to show that the trends observed in the vibration power absorptions distributed in the substructures are consistent with some major findings of various physiological and epidemiological studies, which provides a support to the hypothesis of this study.

Bacterial and fungal biofilm formation on contact lenses and their susceptibility to lens care solutions.

PubMed

Kackar, Siddharth; Suman, Ethel; Kotian, M Shashidhar

2017-01-01

Microbial biofilm formation on contact lenses and lens storage cases may be a risk factor for contact lens-associated corneal infections. Various types of contact lens care solutions are used to reduce microbial growths on lenses. The present study aimed at comparing the growths of biofilms on the different contact lenses and lens cases. The study also aimed at determining the effect of lens care solutions and bacteriophage on these biofilms. One type of hard lens and two types of soft lenses were used for the study. The organisms used were Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 60193 and Escherichia coli ATCC 25922. Biofilm production was performed by modified O'Toole and Kolter method and effect of lens cleaning solutions and a crude coliphage on biofilms was also studied. Results were visualised using scanning electron microscopy and quantitated by colony counting method and spectrophotometric measurement of optical density (OD). Statistical analysis was done by SPSS 11.5, Kruskal-Wallis test and Chi-square test. Soft lens cleaning solutions had a significant inhibitory effect (P = 0.020) on biofilm formation on soft lenses and also lens cases (P < 0.001). Soft lens cleaning solution 2 was more efficient than solution 1. However, no such inhibitory effect was observed with regard to hard lens cleaning solution, but for a significant reduction in the OD values (P < 0.001). There was no significant inhibitory effect by bacteriophages. This study showed the importance of selecting the appropriate lens cleaning solution to prevent biofilm production on contact lenses.

Fine-structure characteristics in the emittance images of a strongly focusing He{sup +} beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sasao, M.; Kobuchi, T.; Kisaki, M.

2010-02-15

The phase space distribution of a strongly focused He{sup +} ion beam source equipped with concave multiaperture electrodes was measured using a pepper-pot plate and a Kapton foil. The substructure of 301 merging He beamlets was clearly observed on a footprint of pepper-pot hole at the beam waist, where the beam density was 500 mA/cm{sup 2}. The position and the width of each beamlet substructure show the effect of interference of beamlets with surrounding one.

Cracks in Complex Bodies: Covariance of Tip Balances

NASA Astrophysics Data System (ADS)

Mariano, Paolo Maria

2008-04-01

In complex bodies, actions due to substructural changes alter (in some cases drastically) the force driving the tip of macroscopic cracks in quasi-static and dynamic growth, and must be represented directly. Here it is proven that tip balances of standard and substructural interactions are covariant. In fact, the former balance follows from the Lagrangian density’s requirement of invariance with respect to the action of the group of diffeomorphisms of the ambient space to itself, the latter balance accrues from an analogous invariance with respect to the action of a Lie group over the manifold of substructural shapes. The evolution equation of the crack tip can be obtained by exploiting invariance with respect to relabeling the material elements in the reference place. The analysis is developed by first focusing on general complex bodies that admit metastable states with substructural dissipation of viscous-like type inside each material element. Then we account for gradient dissipative effects that induce nonconservative stresses; the covariance of tip balances in simple bodies follows as a corollary. When body actions and boundary data of Dirichlet type are absent, the standard variational description of quasi-static crack growth is simply extended to the case of complex materials.

Identifying a new particle with jet substructures

DOE PAGES

Han, Chengcheng; Kim, Doojin; Kim, Minho; ...

2017-01-09

Here, we investigate a potential of determining properties of a new heavy resonance of mass O(1)TeV which decays to collimated jets via heavy Standard Model intermediary states, exploiting jet substructure techniques. Employing the Z gauge boson as a concrete example for the intermediary state, we utilize a "merged jet" defined by a large jet size to capture the two quarks from its decay. The use of the merged jet bene ts the identification of a Z-induced jet as a single, reconstructed object without any combinatorial ambiguity. We also find that jet substructure procedures may enhance features in some kinematic observablesmore » formed with subjet four-momenta extracted from a merged jet. This observation motivates us to feed subjet momenta into the matrix elements associated with plausible hypotheses on the nature of the heavy resonance, which are further processed to construct a matrix element method (MEM)-based observable. For both moderately and highly boosted Z bosons, we demonstrate that the MEM in combination with jet substructure techniques can be a very powerful tool for identifying its physical properties. Finally, we discuss effects from choosing different jet sizes for merged jets and jet-grooming parameters upon the MEM analyses.« less

Substructural Regularization With Data-Sensitive Granularity for Sequence Transfer Learning.

PubMed

Sun, Shichang; Liu, Hongbo; Meng, Jiana; Chen, C L Philip; Yang, Yu

2018-06-01

Sequence transfer learning is of interest in both academia and industry with the emergence of numerous new text domains from Twitter and other social media tools. In this paper, we put forward the data-sensitive granularity for transfer learning, and then, a novel substructural regularization transfer learning model (STLM) is proposed to preserve target domain features at substructural granularity in the light of the condition of labeled data set size. Our model is underpinned by hidden Markov model and regularization theory, where the substructural representation can be integrated as a penalty after measuring the dissimilarity of substructures between target domain and STLM with relative entropy. STLM can achieve the competing goals of preserving the target domain substructure and utilizing the observations from both the target and source domains simultaneously. The estimation of STLM is very efficient since an analytical solution can be derived as a necessary and sufficient condition. The relative usability of substructures to act as regularization parameters and the time complexity of STLM are also analyzed and discussed. Comprehensive experiments of part-of-speech tagging with both Brown and Twitter corpora fully justify that our model can make improvements on all the combinations of source and target domains.

Substructures in the temporal distribution of atmospheric Cerenkov light in EAS

NASA Astrophysics Data System (ADS)

Bosia, G.; Navarra, G.; Saavedra, O.; Boehm, E.

1980-06-01

Particle density and arrival time distribution of atmospheric Cerenkov light (ACL) was measured simultaneously in individual air showers at Pic du Midi. Substructures were observed in the arrival time distribution of the ACL. The arrival time is related to a position in the shower plane which indicates the existence of density variations, i.e., substructures in the lateral distribution of particles. The frequency of substructures is a few percent, and core distances of up to tens of meters were observed.

The effect of prescription eyewear on ocular exposure to ultraviolet radiation.

PubMed Central

Rosenthal, F S; Bakalian, A E; Taylor, H R

1986-01-01

Several studies have suggested that ultraviolet radiation in sunlight may cause cataracts and other eye disease. We evaluated the effect of prescription eyewear in attenuating ocular exposure to ultraviolet radiation (UVR) in the sunlight portions of the ultraviolet spectrum (295-350 nm). Using natural sunlight as the source, the attenuation was measured with two ultraviolet detectors, one sensitive to only UVB (295-315 nm) and one sensitive to both UVA and UVB (295-350 nm). A random sample of spectacles, spectacle lenses, and contact lenses was examined. The average transmission, as measured with either detector, was highest for soft contact lenses, followed by glass spectacle lenses, untinted hard contact lenses, and plastic spectacle lenses. Measurements performed with mannikins wearing spectacles showed that an average of 6.6 per cent of incident radiation reached the eye even when the lenses were covered with black opaque tape. The amount of exposure was increased substantially when the spectacles were moved 0.6 cm away from the forehead. The results show that the protection against ultraviolet exposure provided by prescription eyewear is highly variable and depends largely on its composition, size, and wearing position. PMID:3752323

Blooming Trees: Substructures and Surrounding Groups of Galaxy Clusters

NASA Astrophysics Data System (ADS)

Yu, Heng; Diaferio, Antonaldo; Serra, Ana Laura; Baldi, Marco

2018-06-01

We develop the Blooming Tree Algorithm, a new technique that uses spectroscopic redshift data alone to identify the substructures and the surrounding groups of galaxy clusters, along with their member galaxies. Based on the estimated binding energy of galaxy pairs, the algorithm builds a binary tree that hierarchically arranges all of the galaxies in the field of view. The algorithm searches for buds, corresponding to gravitational potential minima on the binary tree branches; for each bud, the algorithm combines the number of galaxies, their velocity dispersion, and their average pairwise distance into a parameter that discriminates between the buds that do not correspond to any substructure or group, and thus eventually die, and the buds that correspond to substructures and groups, and thus bloom into the identified structures. We test our new algorithm with a sample of 300 mock redshift surveys of clusters in different dynamical states; the clusters are extracted from a large cosmological N-body simulation of a ΛCDM model. We limit our analysis to substructures and surrounding groups identified in the simulation with mass larger than 1013 h ‑1 M ⊙. With mock redshift surveys with 200 galaxies within 6 h ‑1 Mpc from the cluster center, the technique recovers 80% of the real substructures and 60% of the surrounding groups; in 57% of the identified structures, at least 60% of the member galaxies of the substructures and groups belong to the same real structure. These results improve by roughly a factor of two the performance of the best substructure identification algorithm currently available, the σ plateau algorithm, and suggest that our Blooming Tree Algorithm can be an invaluable tool for detecting substructures of galaxy clusters and investigating their complex dynamics.

THE SEGUE K GIANT SURVEY. III. QUANTIFYING GALACTIC HALO SUBSTRUCTURE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Janesh, William; Morrison, Heather L.; Ma, Zhibo

2016-01-10

We statistically quantify the amount of substructure in the Milky Way stellar halo using a sample of 4568 halo K giant stars at Galactocentric distances ranging over 5–125 kpc. These stars have been selected photometrically and confirmed spectroscopically as K giants from the Sloan Digital Sky Survey’s Sloan Extension for Galactic Understanding and Exploration project. Using a position–velocity clustering estimator (the 4distance) and a model of a smooth stellar halo, we quantify the amount of substructure in the halo, divided by distance and metallicity. Overall, we find that the halo as a whole is highly structured. We also confirm earliermore » work using blue horizontal branch (BHB) stars which showed that there is an increasing amount of substructure with increasing Galactocentric radius, and additionally find that the amount of substructure in the halo increases with increasing metallicity. Comparing to resampled BHB stars, we find that K giants and BHBs have similar amounts of substructure over equivalent ranges of Galactocentric radius. Using a friends-of-friends algorithm to identify members of individual groups, we find that a large fraction (∼33%) of grouped stars are associated with Sgr, and identify stars belonging to other halo star streams: the Orphan Stream, the Cetus Polar Stream, and others, including previously unknown substructures. A large fraction of sample K giants (more than 50%) are not grouped into any substructure. We find also that the Sgr stream strongly dominates groups in the outer halo for all except the most metal-poor stars, and suggest that this is the source of the increase of substructure with Galactocentric radius and metallicity.« less

A decentralized linear quadratic control design method for flexible structures

NASA Technical Reports Server (NTRS)

Su, Tzu-Jeng; Craig, Roy R., Jr.

1990-01-01

A decentralized suboptimal linear quadratic control design procedure which combines substructural synthesis, model reduction, decentralized control design, subcontroller synthesis, and controller reduction is proposed for the design of reduced-order controllers for flexible structures. The procedure starts with a definition of the continuum structure to be controlled. An evaluation model of finite dimension is obtained by the finite element method. Then, the finite element model is decomposed into several substructures by using a natural decomposition called substructuring decomposition. Each substructure, at this point, still has too large a dimension and must be reduced to a size that is Riccati-solvable. Model reduction of each substructure can be performed by using any existing model reduction method, e.g., modal truncation, balanced reduction, Krylov model reduction, or mixed-mode method. Then, based on the reduced substructure model, a subcontroller is designed by an LQ optimal control method for each substructure independently. After all subcontrollers are designed, a controller synthesis method called substructural controller synthesis is employed to synthesize all subcontrollers into a global controller. The assembling scheme used is the same as that employed for the structure matrices. Finally, a controller reduction scheme, called the equivalent impulse response energy controller (EIREC) reduction algorithm, is used to reduce the global controller to a reasonable size for implementation. The EIREC reduced controller preserves the impulse response energy of the full-order controller and has the property of matching low-frequency moments and low-frequency power moments. An advantage of the substructural controller synthesis method is that it relieves the computational burden associated with dimensionality. Besides that, the SCS design scheme is also a highly adaptable controller synthesis method for structures with varying configuration, or varying mass and stiffness properties.

Time delay in Swiss cheese gravitational lensing

NASA Astrophysics Data System (ADS)

Chen, B.; Kantowski, R.; Dai, X.

2010-08-01

We compute time delays for gravitational lensing in a flat Λ dominated cold dark matter Swiss cheese universe. We assume a primary and secondary pair of light rays are deflected by a single point mass condensation described by a Kottler metric (Schwarzschild with Λ) embedded in an otherwise homogeneous cosmology. We find that the cosmological constant’s effect on the difference in arrival times is nonlinear and at most around 0.002% for a large cluster lens; however, we find differences from time delays predicted by conventional linear lensing theory that can reach ˜4% for these large lenses. The differences in predicted delay times are due to the failure of conventional lensing to incorporate the lensing mass into the mean mass density of the universe.

Probabilities for gravitational lensing by point masses in a locally inhomogeneous universe

NASA Technical Reports Server (NTRS)

Isaacson, Jeffrey A.; Canizares, Claude R.

1989-01-01

Probability functions for gravitational lensing by point masses that incorporate Poisson statistics and flux conservation are formulated in the Dyer-Roeder construction. Optical depths to lensing for distant sources are calculated using both the method of Press and Gunn (1973) which counts lenses in an otherwise empty cone, and the method of Ehlers and Schneider (1986) which projects lensing cross sections onto the source sphere. These are then used as parameters of the probability density for lensing in the case of a critical (q0 = 1/2) Friedmann universe. A comparison of the probability functions indicates that the effects of angle-averaging can be well approximated by adjusting the average magnification along a random line of sight so as to conserve flux.

Ballast and Subgrade requirements study : railroad track substructure - design and performance evaluation practices

DOT National Transportation Integrated Search

1983-06-30

Earth materials--i.e., soil and rock--form the substructure (ballast, subballast, and subgrade) of all railroad track. In this report, the most suitable technology and design criteria as related to design of the substructure are identified based on a...

A Comparison of Reduced Order Modeling Techniques Used in Dynamic Substructuring.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roettgen, Dan; Seegar, Ben; Tai, Wei Che

Experimental dynamic substructuring is a means whereby a mathematical model for a substructure can be obtained experimentally and then coupled to a model for the rest of the assembly to predict the response. Recently, various methods have been proposed that use a transmission simulator to overcome sensitivity to measurement errors and to exercise the interface between the substructures; including the Craig-Bampton, Dual Craig-Bampton, and Craig-Mayes methods. This work compares the advantages and disadvantages of these reduced order modeling strategies for two dynamic substructuring problems. The methods are first used on an analytical beam model to validate the methodologies. Then theymore » are used to obtain an experimental model for structure consisting of a cylinder with several components inside connected to the outside case by foam with uncertain properties. This represents an exceedingly difficult structure to model and so experimental substructuring could be an attractive way to obtain a model of the system.« less

A Comparison of Reduced Order Modeling Techniques Used in Dynamic Substructuring [PowerPoint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roettgen, Dan; Seeger, Benjamin; Tai, Wei Che

Experimental dynamic substructuring is a means whereby a mathematical model for a substructure can be obtained experimentally and then coupled to a model for the rest of the assembly to predict the response. Recently, various methods have been proposed that use a transmission simulator to overcome sensitivity to measurement errors and to exercise the interface between the substructures; including the Craig-Bampton, Dual Craig-Bampton, and Craig-Mayes methods. This work compares the advantages and disadvantages of these reduced order modeling strategies for two dynamic substructuring problems. The methods are first used on an analytical beam model to validate the methodologies. Then theymore » are used to obtain an experimental model for structure consisting of a cylinder with several components inside connected to the outside case by foam with uncertain properties. This represents an exceedingly difficult structure to model and so experimental substructuring could be an attractive way to obtain a model of the system.« less

Effects of dental magnification lenses on indirect vision: a pilot study.

PubMed

Hoerler, Sarah B; Branson, Bonnie G; High, Anne M; Mitchell, Tanya Villalpando

2012-01-01

The purpose of this pilot study was to evaluate the effect of magnification lenses on the indirect vision skills of dental hygiene students. This pilot study examined the accuracy and efficiency of dental hygiene students' indirect vision skills while using traditional safety lenses and magnification lenses. The sample was comprised of 14 students in their final semester of a dental hygiene program. A crossover study approach was utilized, with each participant randomly assigned to a specific order of eyewear. The study included evaluation of each participant taking part in 2 separate clinical sessions. During the first session, each participant completed a clinical exercise on a dental manikin marked with 15 dots throughout the oral cavity while wearing the randomly as signed eyewear, and then completed a similar exercise on a differently marked dental manikin while wearing the randomly assigned eyewear. This procedure was repeated at a second clinical session, however, the dental manikin and eyewear pairings were reversed. Accuracy was measured on the number of correctly identified dots and efficiency was measured by the time it took to identify the dots. Perceptions of the participants' use of magnification lenses and the participants' opinion of the use of magnification lenses in a dental hygiene curriculum were evaluated using a questionnaire. Comparing the mean of the efficiency scores, students are more efficient at identifying indirect vision points with the use of magnification lenses (3 minutes, 36 seconds) than with traditional safety lenses (3 minutes, 56 seconds). Comparing the measurement of accuracy, students are more accurate at identifying indirect vision points with traditional safety lenses (84%) as com pared to magnification lenses (79%). Overall, the students report ed an increased quality of dental hygiene treatment provided in the clinical setting and an improved clinical posture while treating patients with the use of magnification lenses. This study did not produce statistically significant data to support the use of magnification lenses to enhance indirect vision skills among dental hygiene students, however, students perceived that their indirect vision skills were enhanced by the use of magnification lenses.

Lensing-induced morphology changes in CMB temperature maps in modified gravity theories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Munshi, D.; Coles, P.; Hu, B.

2016-04-01

Lensing of the Cosmic Microwave Background (CMB) changes the morphology of pattern of temperature fluctuations, so topological descriptors such as Minkowski Functionals can probe the gravity model responsible for the lensing. We show how the recently introduced two-to-two and three-to-one kurt-spectra (and their associated correlation functions), which depend on the power spectrum of the lensing potential, can be used to probe modified gravity theories such as f ( R ) theories of gravity and quintessence models. We also investigate models based on effective field theory, which include the constant-Ω model, and low-energy Hořava theories. Estimates of the cumulative signal-to-noise formore » detection of lensing-induced morphology changes, reaches O(10{sup 3}) for the future planned CMB polarization mission COrE{sup +}. Assuming foreground removal is possible to ℓ{sub max}=3000, we show that many modified gravity theories can be rejected with a high level of significance, making this technique comparable in power to galaxy weak lensing or redshift surveys. These topological estimators are also useful in distinguishing lensing from other scattering secondaries at the level of the four-point function or trispectrum. Examples include the kinetic Sunyaev-Zel'dovich (kSZ) effect which shares, with lensing, a lack of spectral distortion. We also discuss the complication of foreground contamination from unsubtracted point sources.« less

On nonlinear finite element analysis in single-, multi- and parallel-processors

NASA Technical Reports Server (NTRS)

Utku, S.; Melosh, R.; Islam, M.; Salama, M.

1982-01-01

Numerical solution of nonlinear equilibrium problems of structures by means of Newton-Raphson type iterations is reviewed. Each step of the iteration is shown to correspond to the solution of a linear problem, therefore the feasibility of the finite element method for nonlinear analysis is established. Organization and flow of data for various types of digital computers, such as single-processor/single-level memory, single-processor/two-level-memory, vector-processor/two-level-memory, and parallel-processors, with and without sub-structuring (i.e. partitioning) are given. The effect of the relative costs of computation, memory and data transfer on substructuring is shown. The idea of assigning comparable size substructures to parallel processors is exploited. Under Cholesky type factorization schemes, the efficiency of parallel processing is shown to decrease due to the occasional shared data, just as that due to the shared facilities.

[Effects of three types of veneering porcelain on bending strength of KAVO(TM) Y-TZP/porcelain bilayered structure].

PubMed

Ma, Ting-ting; Yi, Yuan-fu; Shao, Long-quan; Tian, Jie-mo; Hou, Kang-lin; Zhang, Wei-wei; Wen, Ning; Deng, Bin

2010-10-01

To investigate the effect of three types of veneering porcelain on the bending strength of KAVO Y-TZP/porcelain layered structure. KAVO zirconia ceramics were used as the substructure. To form Y-TZP/porcelain bilayered structure, a leucite-based veneering porcelain was fired on the zirconia substructures by slip-casting technique with dentin washbake, and two nano-fluorapatite-based veneering porcelains were fired on the zirconia substructures by either slip-casting or pressed-on technique with or without liner coverage. The bending strength was tested according to ISO 6872 standard, and the veneered surfaces of the fracture samples were analyzed by scanning electron microscopy (SEM). For covering KAVO zirconia core material, the conventional veneering slurry-porcelain combined with liner or wash firing had significant higher bending strength than pressed-on porcelain. SEM showed that the main failure type at the interface was adhesive failure. Thin layer sintering using washbake program or liner on KAVO zirconia surface increases the surface wettability, and this procedure may be indispensable when veneering on the surface of dental zirconia.

Extracting sets of chemical substructures and protein domains governing drug-target interactions.

PubMed

Yamanishi, Yoshihiro; Pauwels, Edouard; Saigo, Hiroto; Stoven, Véronique

2011-05-23

The identification of rules governing molecular recognition between drug chemical substructures and protein functional sites is a challenging issue at many stages of the drug development process. In this paper we develop a novel method to extract sets of drug chemical substructures and protein domains that govern drug-target interactions on a genome-wide scale. This is made possible using sparse canonical correspondence analysis (SCCA) for analyzing drug substructure profiles and protein domain profiles simultaneously. The method does not depend on the availability of protein 3D structures. From a data set of known drug-target interactions including enzymes, ion channels, G protein-coupled receptors, and nuclear receptors, we extract a set of chemical substructures shared by drugs able to bind to a set of protein domains. These two sets of extracted chemical substructures and protein domains form components that can be further exploited in a drug discovery process. This approach successfully clusters protein domains that may be evolutionary unrelated but that bind a common set of chemical substructures. As shown in several examples, it can also be very helpful for predicting new protein-ligand interactions and addressing the problem of ligand specificity. The proposed method constitutes a contribution to the recent field of chemogenomics that aims to connect the chemical space with the biological space.

Extreme Brightness Temperatures and Refractive Substructure in 3C273 with RadioAstron

NASA Astrophysics Data System (ADS)

Johnson, Michael D.; Kovalev, Yuri Y.; Gwinn, Carl R.; Gurvits, Leonid I.; Narayan, Ramesh; Macquart, Jean-Pierre; Jauncey, David L.; Voitsik, Peter A.; Anderson, James M.; Sokolovsky, Kirill V.; Lisakov, Mikhail M.

2016-03-01

Earth-space interferometry with RadioAstron provides the highest direct angular resolution ever achieved in astronomy at any wavelength. RadioAstron detections of the classic quasar 3C 273 on interferometric baselines up to 171,000 km suggest brightness temperatures exceeding expected limits from the “inverse-Compton catastrophe” by two orders of magnitude. We show that at 18 cm, these estimates most likely arise from refractive substructure introduced by scattering in the interstellar medium. We use the scattering properties to estimate an intrinsic brightness temperature of 7× {10}12 {{K}}, which is consistent with expected theoretical limits, but which is ˜15 times lower than estimates that neglect substructure. At 6.2 cm, the substructure influences the measured values appreciably but gives an estimated brightness temperature that is comparable to models that do not account for the substructure. At 1.35 {{cm}}, the substructure does not affect the extremely high inferred brightness temperatures, in excess of {10}13 {{K}}. We also demonstrate that for a source having a Gaussian surface brightness profile, a single long-baseline estimate of refractive substructure determines an absolute minimum brightness temperature, if the scattering properties along a given line of sight are known, and that this minimum accurately approximates the apparent brightness temperature over a wide range of total flux densities.

Sachem: a chemical cartridge for high-performance substructure search.

PubMed

Kratochvíl, Miroslav; Vondrášek, Jiří; Galgonek, Jakub

2018-05-23

Structure search is one of the valuable capabilities of small-molecule databases. Fingerprint-based screening methods are usually employed to enhance the search performance by reducing the number of calls to the verification procedure. In substructure search, fingerprints are designed to capture important structural aspects of the molecule to aid the decision about whether the molecule contains a given substructure. Currently available cartridges typically provide acceptable search performance for processing user queries, but do not scale satisfactorily with dataset size. We present Sachem, a new open-source chemical cartridge that implements two substructure search methods: The first is a performance-oriented reimplementation of substructure indexing based on the OrChem fingerprint, and the second is a novel method that employs newly designed fingerprints stored in inverted indices. We assessed the performance of both methods on small, medium, and large datasets containing 1, 10, and 94 million compounds, respectively. Comparison of Sachem with other freely available cartridges revealed improvements in overall performance, scaling potential and screen-out efficiency. The Sachem cartridge allows efficient substructure searches in databases of all sizes. The sublinear performance scaling of the second method and the ability to efficiently query large amounts of pre-extracted information may together open the door to new applications for substructure searches.

Contact lenses to slow progression of myopia.

PubMed

Sankaridurg, Padmaja

2017-09-01

The prevalence of myopia has been steadily rising, with 28 per cent of the global population said to be affected in 2010 and to rise to affect nearly 50 per cent by 2050. Increasing levels of myopia increase the risk of vision impairment and in particular, high myopia is associated with the risk of serious and permanent visual disability due to associated sight-threatening complications. To stem the burden associated with higher levels of myopia, there are efforts to slow the progression of myopia, and several optical and pharmaceutical strategies have been found useful in slowing myopia to varying degrees. More recently, numerous multifocal soft contact lenses and extended depth of focus soft contact lenses (collectively referred to as myopia control contact lenses) were found effective in slowing myopia. As opposed to overnight orthokeratology, myopia control contact lenses are worn during the day and the hypotheses proposed to explain the efficacy of these lenses are generally based on the premise that the stimulus for eye growth is a defocused retinal image with hyperopic blur either centrally or peripherally. Although the individual power profiles of the lenses vary, the contact lens generally incorporates 'positive power' to reduce the hyperopic blur and/or impose myopic defocus or in the case of the extended depth of focus lens, has a power profile designed to optimise retinal image quality for points on or in front of the retina. The use of soft contact lenses as a platform for myopia control offers an exciting and effective avenue to manage myopia but there is a need for further research on issues such as the mechanism underlying control of myopia, improving efficacy with lenses, and understanding rebound on discontinuation. More significantly, although contact lenses are generally safe and improve quality of life in older children, one of the major challenges for improved uptake and acceptance of contact lenses centres on the perceived risk of complications with lens wear. This issue needs to be addressed. © 2017 Optometry Australia.

BIASES IN PHYSICAL PARAMETER ESTIMATES THROUGH DIFFERENTIAL LENSING MAGNIFICATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Er Xinzhong; Ge Junqiang; Mao Shude, E-mail: xer@nao.cas.cn

2013-06-20

We study the lensing magnification effect on background galaxies. Differential magnification due to different magnifications of different source regions of a galaxy will change the lensed composite spectra. The derived properties of the background galaxies are therefore biased. For simplicity, we model galaxies as a superposition of an axis-symmetric bulge and a face-on disk in order to study the differential magnification effect on the composite spectra. We find that some properties derived from the spectra (e.g., velocity dispersion, star formation rate, and metallicity) are modified. Depending on the relative positions of the source and the lens, the inferred results canmore » be either over- or underestimates of the true values. In general, for an extended source at strong lensing regions with high magnifications, the inferred physical parameters (e.g., metallicity) can be strongly biased. Therefore, detailed lens modeling is necessary to obtain the true properties of the lensed galaxies.« less

The effect of Limber and flat-sky approximations on galaxy weak lensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lemos, Pablo; Challinor, Anthony; Efstathiou, George, E-mail: pl411@cam.ac.uk, E-mail: a.d.challinor@ast.cam.ac.uk, E-mail: gpe@ast.cam.ac.uk

We review the effect of the commonly-used Limber and flat-sky approximations on the calculation of shear power spectra and correlation functions for galaxy weak lensing. These approximations are accurate at small scales, but it has been claimed recently that their impact on low multipoles could lead to an increase in the amplitude of the mass fluctuations inferred from surveys such as CFHTLenS, reducing the tension between galaxy weak lensing and the amplitude determined by Planck from observations of the cosmic microwave background. Here, we explore the impact of these approximations on cosmological parameters derived from weak lensing surveys, using themore » CFHTLenS data as a test case. We conclude that the use of small-angle approximations for cosmological parameter estimation is negligible for current data, and does not contribute to the tension between current weak lensing surveys and Planck.« less

Constraining stochastic gravitational wave background from weak lensing of CMB B-modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaikh, Shabbir; Mukherjee, Suvodip; Souradeep, Tarun

2016-09-01

A stochastic gravitational wave background (SGWB) will affect the CMB anisotropies via weak lensing. Unlike weak lensing due to large scale structure which only deflects photon trajectories, a SGWB has an additional effect of rotating the polarization vector along the trajectory. We study the relative importance of these two effects, deflection and rotation, specifically in the context of E-mode to B-mode power transfer caused by weak lensing due to SGWB. Using weak lensing distortion of the CMB as a probe, we derive constraints on the spectral energy density (Ω{sub GW}) of the SGWB, sourced at different redshifts, without assuming anymore » particular model for its origin. We present these bounds on Ω{sub GW} for different power-law models characterizing the SGWB, indicating the threshold above which observable imprints of SGWB must be present in CMB.« less

Gravitational Lensing Effect on the Two-Point Correlation of Hot Spots in the Cosmic Microwave Background.

PubMed

Takada; Komatsu; Futamase

2000-04-20

We investigate the weak gravitational lensing effect that is due to the large-scale structure of the universe on two-point correlations of local maxima (hot spots) in the two-dimensional sky map of the cosmic microwave background (CMB) anisotropy. According to the Gaussian random statistics, as most inflationary scenarios predict, the hot spots are discretely distributed, with some characteristic angular separations on the last scattering surface that are due to oscillations of the CMB angular power spectrum. The weak lensing then causes pairs of hot spots, which are separated with the characteristic scale, to be observed with various separations. We found that the lensing fairly smooths out the oscillatory features of the two-point correlation function of hot spots. This indicates that the hot spot correlations can be a new statistical tool for measuring the shape and normalization of the power spectrum of matter fluctuations from the lensing signatures.

Modeling The Distribution Of Dark Matter And Its Connection To Galaxies

NASA Astrophysics Data System (ADS)

Mao, Yao-Yuan

2016-06-01

Despite the mysterious nature of dark matter and dark energy, the Lambda-Cold Dark Matter (LCDM) model provides a reasonably accurate description of the evolution of the cosmos and the distribution of galaxies. Today, we are set to tackle more specific and quantitative questions about the galaxy formation physics, the nature of dark matter, and the connection between the dark and the visible components. The answers to these questions are however elusive, because dark matter is not directly observable, and various unknowns lie between what we can observe and what we can calculate. Hence, mathematical models that bridge the observable and the calculable are essential for the study of modern cosmology. The aim of my thesis work is to improve existing models and also to construct new models for various aspects of the dark matter distribution, as dark matter structures the cosmic web and forms the nests of visible galaxies. Utilizing a series of cosmological dark matter simulations which span a wide dynamical range and a statistical sample of zoom-in simulations which focus on individual dark matter halos, we develop models for the spatial and velocity distribution of dark matter particles, the abundance of dark substructures, and the empirical connection between dark matter and galaxies. As more precise observational results become available, more accurate models are then required to test the consistency between these results and the LCDM predictions. For all the models we investigate, we find that the formation history of dark matter halos always plays a crucial role. Neglecting the halo formation history would result in systematic biases when we interpret various observational results, including dark matter direct detection experiments, the detection of dark substructures with strong-lensed systems, the large-scale spatial clustering of galaxies, and the abundance of dwarf galaxies. Rectifying this, our work will enable us to fully utilize the complementary power of diverse observational datasets to test the LCDM model and to seek new physics.

The evolution of the deformation substructure in a Ni-Co-Cr equiatomic solid solution alloy

DOE PAGES

Miao, Jiashi; Slone, C. E.; Smith, T. M.; ...

2017-05-15

The equiatomic NiCoCr alloy exhibits an excellent combination of strength and ductility, even greater than the FeNiCrCoMn high entropy alloy, and also displays a simultaneous increase in strength and ductility with decreasing the testing temperature. To systemically investigate the origin of the exceptional properties of NiCoCr alloy, which are related to the evolution of the deformation substructure with strain, interrupted tensile testing was conducted on the equiatomic NiCoCr single-phase solid solution alloy at both cryogenic and room temperatures at five different plastic strain levels of 1.5%, 6.5%, 29%, 50% and 70%. The evolution of deformation substructure was examined using electronmore » backscatter diffraction (EBSD), transmission Kikuchi diffraction (TKD), conventional transmission electron microscopy (CTEM), diffraction contrast imaging using STEM (DCI-STEM) and atomic resolution scanning transmission electron microscopy. While the deformation substructure mainly consisted of planar dislocation slip and the dissociation of dislocations into stacking faults at small strain levels (≤6.5%), at larger strain levels, additional substructures including nanotwins and a new phase with hexagonal close packed (HCP) lamellae also appeared. The volume fraction of the HCP lamellae increases with increasing deformation, especially at cryogenic temperature. First principles calculations at 0 K indicate that the HCP phase is indeed energetically favorable relative to FCC for this composition. In conclusion, the effects of the nanotwin and HCP lamellar structures on hardening rate and ductility at both cryogenic and room temperature are qualitatively discussed.« less

Lensing convergence in galaxy clustering in ΛCDM and beyond

NASA Astrophysics Data System (ADS)

Villa, Eleonora; Di Dio, Enea; Lepori, Francesca

2018-04-01

We study the impact of neglecting lensing magnification in galaxy clustering analyses for future galaxy surveys, considering the ΛCDM model and two extensions: massive neutrinos and modifications of General Relativity. Our study focuses on the biases on the constraints and on the estimation of the cosmological parameters. We perform a comprehensive investigation of these two effects for the upcoming photometric and spectroscopic galaxy surveys Euclid and SKA for different redshift binning configurations. We also provide a fitting formula for the magnification bias of SKA. Our results show that the information present in the lensing contribution does improve the constraints on the modified gravity parameters whereas the lensing constraining power is negligible for the ΛCDM parameters. For photometric surveys the estimation is biased for all the parameters if lensing is not taken into account. This effect is particularly significant for the modified gravity parameters. Conversely for spectroscopic surveys the bias is below one sigma for all the parameters. Our findings show the importance of including lensing in galaxy clustering analyses for testing General Relativity and to constrain the parameters which describe its modifications.

How to measure slab-off and reverse slab prism in spectacle lenses.

PubMed

Christoff, Alexander; Guyton, David L

2007-08-01

It is well known that new spectacle lenses for the correction of anisometropia can induce diplopia with reading. The difference in the powers of the lenses induces a net prismatic effect that can cause double vision through off-center areas of the lenses. This is particularly bothersome when patients try to read, often noting vertical double vision in attempted downgaze, especially through multifocal add segments. This induced prismatic effect can be compensated at one level of downgaze by the use of slab-off or reverse slab prism. Typically the slab-off correction is ground into the stronger minus, or weaker plus lens. Reverse slab is ground into the weaker minus, or stronger plus, lens. Unfortunately, determining the amount of slab-off prism already incorporated into spectacle lenses is nonintuitive and inconvenient. This usually requires the use of a lens clock, which is not widely accessible to many ophthalmology practices. A simple technique, described in the past but poorly known, is illustrated here for quickly measuring slab-off and reverse slab prism prescription lenses in the clinic with a common manual lens meter.

A closer look at the quadruply lensed quasar PSOJ0147: spectroscopic redshifts and microlensing effect

NASA Astrophysics Data System (ADS)

Lee, Chien-Hsiu

2018-04-01

I present a timely spectroscopic follow-up of the newly discovered, quadruply lensed quasar PSOJ0147 from the Pan-STARRS 1 survey. The newly acquired optical spectra with GMOS onboard the Gemini North Telescope allow us to pin down the redshifts of both the foreground lensing galaxy and the background lensed quasar to be z = 0.572 and 2.341, providing a firm basis for cosmography with future high-cadence photometric monitoring. I also inspect difference spectra from two of the quasar images, revealing the microlensing effect. Long-term spectroscopic follow-ups will shed lights on the structure of the active galactic nucleus and its environment.

Amplification and polarization of supernovae by gravitational lensing

NASA Technical Reports Server (NTRS)

Schneider, P.; Wagoner, Robert V.

1987-01-01

The gravitational lensing of supernovae by individual masses which could comprise the dark matter is analyzed. Detailed predictions of the amplification and polarization are presented, including effects of a galactic environment. Their time dependence is produced by the expansion of the supernovae beam within the lens. The fraction of supernovae which might thus be identified as being lensed in surveys at proposed limiting magnitudes is estimated. These two effects could provide the only known unique signature of microlensing.

An evaluation of 1-day disposable contact lens wear in a population of allergy sufferers.

PubMed

Hayes, Valérie Y; Schnider, Cristina M; Veys, Jane

2003-06-01

This was a multi-site, 128-subject, bilateral crossover study to evaluate subjective comfort and slit-lamp findings with 1-day disposable contact lenses in a population of allergy sufferers during periods when allergen levels were elevated. The study involved 1-month of single-use daily wear with a 1-day disposable test lens (1. DAY ACUVUE Brand Contact Lenses, Johnson & Johnson Vision Care) and 1-month of daily wear with subjects' habitual lenses replaced to their usual replacement schedule. Pollen and mould counts were obtained for each site 1 week prior to the study and twice weekly throughout the study period. Subjective comfort and slit-lamp findings were recorded at baseline and after 1-month's wear of each modality. Sixty-seven percent of subjects agreed that the 1-day disposable lenses provided improved comfort when compared to the lenses they wore prior to the study, compared with 18% agreeing that the new pair of habitual lenses provided improved comfort. The 1-day disposable lenses showed greater improvement in slit-lamp findings from baseline than new habitual lenses. The use of 1-day disposable lenses is an effective strategy for managing allergy-suffering contact lens wearers.

The epidemiology of microbial keratitis with silicone hydrogel contact lenses.

PubMed

Stapleton, Fiona; Keay, Lisa; Edwards, Katie; Holden, Brien

2013-01-01

It was widely anticipated that after the introduction of silicone hydrogel lenses, the risk of microbial keratitis would be lower than with hydrogel lenses because of the reduction in hypoxic effects on the corneal epithelium. Large-scale epidemiological studies have confirmed that the absolute and relative risk of microbial keratitis is unchanged with overnight use of silicone hydrogel materials. The key findings include the following: (1) The risk of infection with 30 nights of silicone hydrogel use is equivalent to 6 nights of hydrogel extended wear; (2) Occasional overnight lens use is associated with a greater risk than daily lens use; (3) The rate of vision loss due to corneal infection with silicone hydrogel contact lenses is similar to that seen in hydrogel lenses; (4) The spectrum of causative organisms is similar to that seen in hydrogel lenses, and the material type does not impact the corneal location of presumed microbial keratitis; and (5) Modifiable risk factors for infection include overnight lens use, the degree of exposure, failing to wash hands before lens handling, and storage case hygiene practice. The lack of change in the absolute risk of disease would suggest that exposure to large number of pathogenic organisms can overcome any advantages obtained from eliminating the hypoxic effects of contact lenses. Epidemiological studies remain important in the assessment of new materials and modalities. Consideration of an early adopter effect with studies involving new materials and modalities and further investigation of the impact of second-generation silicone hydrogel materials is warranted.

Accommodation, refractive error and eye growth in chickens.

PubMed

Schaeffel, F; Glasser, A; Howland, H C

1988-01-01

We raised chickens with defocusing lenses of differing powers in front of their eyes. For this purpose, small hoods made from soft, thin leather were carefully fitted to their heads. Lenses were attached to the hoods by velcro fasteners and could be easily removed for cleaning. The powers of the lenses were such that their optical effects could be compensated for by accommodation. It was verified by infrared (IR) photoretinoscopy that the chickens could keep their retinal images in focus. Wearing a lens resulted in a consistent shift of the non cycloplegic refractive state (measured without the lens) which was in the direction to compensate for the lens. We used a sensitive technique (precision = +/- 50 micron as estimated from the variability of repeated measurements) to measure the posterior nodal distance (PND) in excised eyes of birds grown with lenses. The PND, in turn, was used to compare eyes treated with different lenses. It was found that the PND was increased in eyes which were treated with negative lenses compared to those treated with positive lenses. This effect occurs independently in both eyes and it is not due to changes in corneal curvature. We discuss our result in terms of a closed-loop feedback system for the regulation of eye growth.

A comparison of four different lens mappers.

PubMed

Larrue, Denis; Legeard, Morgane

2014-11-01

Recently, a number of lens mappers have become available for measuring the detailed optical properties of progressive addition lenses (PALs). The goal of this study was to compare the results obtained from several different lens mappers for a range of different lenses. The optical power maps of six lenses-two single-vision lenses, a parallel-sided slide, a flat prism, and two progressive lenses-were measured using four different lens mappers: the Dual Lens Mapper, the Nimo TR4005, the Rotlex Class Plus, and the Visionix VM2500. The repeatability of the instruments was also evaluated. All lens mappers gave very repeatable measurements; however, measurements among the lens mappers varied considerably. Differences appeared to be above the tolerance at the optical center for measurements of single-vision lenses, and these differences increase in the periphery up to 1.00 diopter. Similar differences were observed for the PALs, even increased by prism and base curve effect, with figures greater than 1 diopter in the periphery. The measurements made on the prism and lenses with different base curves suggest that base curve, thickness, and prismatic effect can all contribute to the differences among instruments. Measurements of a given lens taken with different lens mappers can vary substantially. Particular caution should be exercised when interpreting power maps for PALs taken with different instruments.

The effect of optical system design for laser micro-hole drilling process

NASA Astrophysics Data System (ADS)

Ding, Chien-Fang; Lan, Yin-Te; Chien, Yu-Lun; Young, Hong-Tsu

2017-08-01

Lasers are a promising high accuracy tool to make small holes in composite or hard material. They offer advantages over the conventional machining process, which is time consuming and has scaling limitations. However, the major downfall in laser material processing is the relatively large heat affect zone or number of molten burrs it generates, even when using nanosecond lasers over high-cost ultrafast lasers. In this paper, we constructed a nanosecond laser processing system with a 532 nm wavelength laser source. In order to enhance precision and minimize the effect of heat generation with the laser drilling process, we investigated the geometric shape of optical elements and analyzed the images using the modulation transfer function (MTF) and encircled energy (EE) by using optical software Zemax. We discuss commercial spherical lenses, including plano-convex lenses, bi-convex lenses, plano-concave lenses, bi-concave lenses, best-form lenses, and meniscus lenses. Furthermore, we determined the best lens configuration by image evaluation, and then verified the results experimentally by carrying out the laser drilling process on multilayer flexible copper clad laminate (FCCL). The paper presents the drilling results obtained with different lens configurations and found the best configuration had a small heat affect zone and a clean edge along laser-drilled holes.

Gravitational lensing of supernovae by dark matter candidates of mass M greater than about 0.001 solar masses

NASA Technical Reports Server (NTRS)

Wagoner, Robert V.; Linder, Eric V.

1987-01-01

A review is presented concerning the gravitational lensing of supernovae by intervening condensed objects, including dark matter candidates such as dim stars and black holes. the expansion of the supernova beam within the lens produces characteristic time-dependent amplification and polarization which depend upon the mass of the lens. The effects of the shearing of the beam due to surrounding masses are considered, although the study of these effects is confined to isolated masses whose size is much less than that of the supernova (about 10 to the 15th cm). Equations for the effects of lensing and graphs comparing these effects in different classes of supernovae are compared. It is found that candidates for lensing would be those supernovae at least as bright as their parent galaxy, or above the range of luminosities expected for their spectral class.

Discovering interesting molecular substructures for molecular classification.

PubMed

Lam, Winnie W M; Chan, Keith C C

2010-06-01

Given a set of molecular structure data preclassified into a number of classes, the molecular classification problem is concerned with the discovering of interesting structural patterns in the data so that "unseen" molecules not originally in the dataset can be accurately classified. To tackle the problem, interesting molecular substructures have to be discovered and this is done typically by first representing molecular structures in molecular graphs, and then, using graph-mining algorithms to discover frequently occurring subgraphs in them. These subgraphs are then used to characterize different classes for molecular classification. While such an approach can be very effective, it should be noted that a substructure that occurs frequently in one class may also does occur in another. The discovering of frequent subgraphs for molecular classification may, therefore, not always be the most effective. In this paper, we propose a novel technique called mining interesting substructures in molecular data for classification (MISMOC) that can discover interesting frequent subgraphs not just for the characterization of a molecular class but also for the distinguishing of it from the others. Using a test statistic, MISMOC screens each frequent subgraph to determine if they are interesting. For those that are interesting, their degrees of interestingness are determined using an information-theoretic measure. When classifying an unseen molecule, its structure is then matched against the interesting subgraphs in each class and a total interestingness measure for the unseen molecule to be classified into a particular class is determined, which is based on the interestingness of each matched subgraphs. The performance of MISMOC is evaluated using both artificial and real datasets, and the results show that it can be an effective approach for molecular classification.

Is There a Cosmological Constant?

NASA Technical Reports Server (NTRS)

Kochanek, Christopher; Oliversen, Ronald J. (Technical Monitor)

2002-01-01

The grant contributed to the publication of 18 refereed papers and 5 conference proceedings. The primary uses of the funding have been for page charges, travel for invited talks related to the grant research, and the support of a graduate student, Charles Keeton. The refereed papers address four of the primary goals of the proposal: (1) the statistics of radio lenses as a probe of the cosmological model (#1), (2) the role of spiral galaxies as lenses (#3), (3) the effects of dust on statistics of lenses (#7, #8), and (4) the role of groups and clusters as lenses (#2, #6, #10, #13, #15, #16). Four papers (#4, #5, #11, #12) address general issues of lens models, calibrations, and the relationship between lens galaxies and nearby galaxies. One considered cosmological effects in lensing X-ray sources (#9), and two addressed issues related to the overall power spectrum and theories of gravity (#17, #18). Our theoretical studies combined with the explosion in the number of lenses and the quality of the data obtained for them is greatly increasing our ability to characterize and understand the lens population. We can now firmly conclude both from our study of the statistics of radio lenses and our survey of extinctions in individual lenses that the statistics of optically selected quasars were significantly affected by extinction. However, the limits on the cosmological constant remain at lambda < 0.65 at a 2-sigma confidence level, which is in mild conflict with the results of the Type la supernova surveys. We continue to find that neither spiral galaxies nor groups and clusters contribute significantly to the production of gravitational lenses. The lack of group and cluster lenses is strong evidence for the role of baryonic cooling in increasing the efficiency of galaxies as lenses compared to groups and clusters of higher mass but lower central density. Unfortunately for the ultimate objective of the proposal, improved constraints on the cosmological constant, the next large survey for gravitational lenses did not release its results during the term of the proposal. The research supported the career development. of six graduate students (polar, Fletcher, Herold, Keeton, Deng and Rusin) and two post-docs (Labor and Munoz).

MODEL-FREE MULTI-PROBE LENSING RECONSTRUCTION OF CLUSTER MASS PROFILES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Umetsu, Keiichi

2013-05-20

Lens magnification by galaxy clusters induces characteristic spatial variations in the number counts of background sources, amplifying their observed fluxes and expanding the area of sky, the net effect of which, known as magnification bias, depends on the intrinsic faint-end slope of the source luminosity function. The bias is strongly negative for red galaxies, dominated by the geometric area distortion, whereas it is mildly positive for blue galaxies, enhancing the blue counts toward the cluster center. We generalize the Bayesian approach of Umetsu et al. for reconstructing projected cluster mass profiles, by incorporating multiple populations of background sources for magnification-biasmore » measurements and combining them with complementary lens-distortion measurements, effectively breaking the mass-sheet degeneracy and improving the statistical precision of cluster mass measurements. The approach can be further extended to include strong-lensing projected mass estimates, thus allowing for non-parametric absolute mass determinations in both the weak and strong regimes. We apply this method to our recent CLASH lensing measurements of MACS J1206.2-0847, and demonstrate how combining multi-probe lensing constraints can improve the reconstruction of cluster mass profiles. This method will also be useful for a stacked lensing analysis, combining all lensing-related effects in the cluster regime, for a definitive determination of the averaged mass profile.« less

Physical and mechanical metallurgy of high purity Nb accelerator cavities.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, N. T.; Bieler, T. R.; Pourgoghart , F.

2010-01-01

In the past decade, high Q values have been achieved in high purity Nb superconducting radio frequency (SRF) cavities. Fundamental understanding of the physical metallurgy of Nb that enables these achievements is beginning to reveal what challenges remain to establish reproducible and cost-effective production of high performance SRF cavities. Recent studies of dislocation substructure development and effects of recrystallization arising from welding and heat treatments and their correlations with cavity performance are considered. With better fundamental understanding of the effects of dislocation substructure evolution and recrystallization on electron and phonon conduction, as well as the interior and surface states, itmore » will be possible to design optimal processing paths for cost-effective performance using approaches such as hydroforming, which minimizes or eliminates welds in a cavity.« less

Physical and mechanical metallurgy of high purity Nb for accelerator cavities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bieler, T. R.; Wright, N. T.; Pourboghrat, F.

2010-01-01

In the past decade, high Q values have been achieved in high purity Nb superconducting radio frequency (SRF) cavities. Fundamental understanding of the physical metallurgy of Nb that enables these achievements is beginning to reveal what challenges remain to establish reproducible and cost-effective production of high performance SRF cavities. Recent studies of dislocation substructure development and effects of recrystallization arising from welding and heat treatments and their correlations with cavity performance are considered. With better fundamental understanding of the effects of dislocation substructure evolution and recrystallization on electron and phonon conduction, as well as the interior and surface states, itmore » will be possible to design optimal processing paths for cost-effective performance using approaches such as hydroforming, which minimizes or eliminates welds in a cavity.« less

Thioredoxin, thioredoxin reductase, and alpha-crystallin revive inactivated glyceraldehyde 3-phosphate dehydrogenase in human aged and cataract lens extracts.

PubMed

Yan, Hong; Lou, Marjorie F; Fernando, M Rohan; Harding, John J

2006-10-02

To investigate whether mammalian thioredoxin (Trx) and thioredoxin reductase (TrxR), with or without alpha-crystallin can revive inactivated glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in both the cortex and nucleus of human aged clear and cataract lenses. The lens cortex (including capsule-epithelium) and the nucleus were separated from human aged clear and cataract lenses (grade II and grade IV) with similar average age. The activity of GAPDH in the water-soluble fraction after incubation with or without Trx or/and TrxR for 60 min at 30 degrees C was measured spectrophotometrically. In addition, the effect of a combination of Trx/TrxR and bovine lens alpha-crystallin was investigated. GAPDH activity was lower in the nucleus of clear lenses than in the cortex, and considerably diminished in the cataractous lenses, particularly in the nucleus of cataract lenses grade IV. Trx and TrxR were able to revive the activity of GAPDH markedly in both the cortex and nucleus of the clear and cataract lenses. The percentage increase of activity in the cortex of the clear lenses was less than that of the nucleus in the presence of Trx and TrxR, whereas it was opposite in the cataract lenses. The revival of activity in both the cortex and nucleus from the cataract lenses grade II was higher than that of the grade IV. Moreover, Trx alone, but not TrxR, efficiently enhanced GAPDH activity. The combination of Trx and TrxR had greater effect than that of either alone. In addition, alpha(L)-crystallin enhanced the activity in the cortex of cataract grade II with Trx and TrxR present. However, it failed to provide a statistically significant increase of activity in the nucleus. This is the first evidence to show that mammalian Trx and TrxR are able to revive inactivated GAPDH in human aged clear and cataract lenses, and alpha-crystallin helped this effect. The inactivation of GAPDH during aging and cataract development must be caused in part by disulphide formation and in part by unfolding, and can be recovered by reducing agents and a molecular chaperone.

Assessment of ultraviolet B–blocking effects of weekly disposable contact lenses on corneal surface in a mouse model

PubMed Central

Lin, David Pei-Cheng; Chang, Han-Hsin; Yang, Li-Chien; Huang, Tzu-Ping; Liu, Hsiang-Jui; Chang, Lin-Song; Lin, Chien-Hsun

2013-01-01

Purpose Weekly disposable soft contact lenses have been widely used recently, but their shield effects against ultraviolet (UV) irradiation remain to be evaluated. This study investigated the bioprotective effects of several weekly soft contact lenses against UVB irradiation on the corneal surface in a mouse model. Methods Fifty ICR mice were randomly divided into five groups: (1) blank control, (2) exposed to UVB without contact lens protection, (3) exposed to UVB and protected with Vifilcon A contact lenses, (4) exposed to UVB and protected with Etafilcon A contact lenses, and (5) exposed to UVB and protected with HEMA+MA contact lenses. The exposure to UVB irradiation was performed at 0.72 J/cm2/day after anesthesia for a 7-day period, followed by cornea surface assessment for smoothness, opacity, and grading of lissamine green staining. Tissue sections were prepared for hematoxylin and eosin staining and immunohistochemical detection by using antibodies against myeloperoxidase, cytokeratin-5, P63, Ki-67, nuclear factor-kappa B (p65), cyclooxygenase-2, Fas L, and Fas. Results The results showed impaired corneal surface with myeloperoxidase+ polymorphonuclear leukocyte infiltration into the stroma after UVB exposure, in contrast to the intact status of the blank controls. The corneas with Etafilcon A and HEMA+MA contact lenses maintained more cells positive for cytokeratin-5, P63, and Ki-67 compared to those with Vifilcon A or without contact lens protection. Furthermore, less proinflammatory factors, including nuclear factor-kappa (p65), cyclooxygenase-2, Fas L, and Fas, were induced in the corneas protected by Etafilcon A and HEMA+MA. Conclusions This study demonstrated various protective effects of weekly disposable contact lenses against UVB irradiation. The mouse model used in the present study may be used extensively for in vivo assessment of UV shield efficacy. PMID:23734085

Effects of multipurpose solutions on the adhesion of Acanthamoeba to rigid gas permeable contact lenses.

PubMed

Lee, Ga-Hyun; Yu, Hak-Sun; Lee, Ji-Eun

2016-03-01

To evaluate the effect of multipurpose contact lens care solutions (MPSs) on the adhesion of Acanthamoeba to rigid gas permeable (RGP) contact lenses. Acanthamoeba castellanii (AC) trophozoites were inoculated onto untreated RGP contact lenses (FP, Extra, or Menicon Z), and numbers of trophozoites adhering to lenses were counted under a phase contrast microscope at 18 h post-inoculation (controls). Similarly, adhering trophozoites were counted at 6 h post-inoculation on each of the three RGP lens types with one of three MPSs (Boston Simplus, Menicare Plus, and O2 Care). Scanning electron microscopic examinations were performed to compare lens surfaces. Adhesion of AC trophozoites to untreated FP was greater than to untreated Extra or Menicon Z. Surfaces of Extra and Menicon Z lenses were waxier, smoother, and more homogeneous than those of FP lenses. After treatment with Boston Simplus, adhesion of AC trophozoites was significantly reduced for all lens types as compared with controls (p < 0.0001). Treatments with Menicare Plus or O2 Care reduced the number of adherent AC trophozoites significantly on FP lenses only as compared with controls (p < 0.0001). The adhesion rates of AC trophozoites to RGP lenses depended on lens surfaces. Boston Simplus reduced the adhesion rate of AC trophozoites more than Menicare Plus or O2 Care. Appropriate RGP lens and MPS selection could decrease the prevalence of Acanthamoeba keratitis. © 2016 The Authors Ophthalmic & Physiological Optics © 2016 The College of Optometrists.

Lensing of the CMB: non-Gaussian aspects.

PubMed

Zaldarriaga, M

2001-06-01

We compute the small angle limit of the three- and four-point function of the cosmic microwave background (CMB) temperature induced by the gravitational lensing effect by the large-scale structure of the universe. We relate the non-Gaussian aspects presented in this paper with those in our previous studies of the lensing effects. We interpret the statistics proposed in previous work in terms of different configurations of the four-point function and show how they relate to the statistic that maximizes the S/N.

Effective wavefront aberration measurement of spectacle lenses in as-worn status

NASA Astrophysics Data System (ADS)

Jia, Zhigang; Xu, Kai; Fang, Fengzhou

2018-04-01

An effective wavefront aberration analysis method for measuring spectacle lenses in as-worn status was proposed and verified using an experimental apparatus based on an eye rotation model. Two strategies were employed to improve the accuracy of measurement of the effective wavefront aberrations on the corneal sphere. The influences of three as-worn parameters, the vertex distance, pantoscopic angle, and face form angle, together with the eye rotation and corresponding incident beams, were objectively and quantitatively obtained. The experimental measurements of spherical single vision and freeform progressive addition lenses demonstrate the accuracy and validity of the proposed method and experimental apparatus, which provide a potential means of achieving supernormal vision correction with customization and personalization in optimizing the as-worn status-based design of spectacle lenses and evaluating their manufacturing and imaging qualities.

The Specificity of Colored Lenses as Visual Aids in Retinal Disease.

ERIC Educational Resources Information Center

Gawande, A.; And Others

1992-01-01

This study of the effects of lenses of different colors on the visual abilities and comfort of 20 patients with retinal disease found that, in home trials, the critical issue was density more than color. Office tests of visual acuity and contrast sensitivity with colored lenses did not predict subjective benefit. (Author/JDD)

Relative performance of soft contact lenses having lathe-cut posterior surfaces with and without additional polishing.

PubMed

O'Brien, C; Charman, W N

2006-05-01

After a preliminary investigation of the effects of tool feed rate and spindle speed on the surface roughness of unhydrated, lathe-cut polymacon surfaces, a laboratory and clinical comparison was made between lenses with identical parameters except that the lathe-cut posterior surface was left unpolished in the "test" lenses and was polished in the "control" lenses. The lenses had moulded anterior surfaces. Laboratory comparisons included surface roughness, lens power and its uniformity across the surface. Double-blind clinical trials over 4-hour (27 subjects) and 1-month (10 subjects) periods, involved one eye of each subject wearing a "test" lens and the other, a "control" lens. No clinically significant differences were found between the results for the test and control lenses. It is concluded that today's lathing technology makes a final polishing stage unnecessary.

Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening

PubMed Central

2014-01-01

Analyzing the chemical space coverage in commercial fragment screening collections revealed the overlap between bioactive medicinal chemistry substructures and rule-of-three compliant fragments is only ∼25%. We recommend including these fragments in fragment screening libraries to maximize confidence in discovering hit matter within known bioactive chemical space, while incorporation of nonoverlapping substructures could offer novel hits in screening libraries. Using principal component analysis, polar and three-dimensional substructures display a higher-than-average enrichment of bioactive compounds, indicating increasing representation of these substructures may be beneficial in fragment screening. PMID:24405118

Visual performance with sport-tinted contact lenses in natural sunlight.

PubMed

Erickson, Graham B; Horn, Fraser C; Barney, Tyler; Pexton, Brett; Baird, Richard Y

2009-05-01

The use of tinted and clear contact lenses (CLs) in all aspects of life is becoming a more popular occurrence, particularly in athletic activities. This study broadens previous research regarding performance-tinted CLs and their effects on measures of visual performance. Thirty-three subjects (14 male, 19 female) were fitted with clear B&L Optima 38, 50% visible light transmission Amber and 36% visible light transmission Gray-Green Nike Maxsight CLs in an individualized randomized sequence. Subjects were dark-adapted with welding goggles before testing and in between subtests involving a Bailey-Lovie chart and the Haynes Distance Rock test. The sequence of testing was repeated for each lens modality. The Amber and Gray-Green lenses enabled subjects to recover vision faster in bright sunlight compared with clear lenses. Also, subjects were able to achieve better visual recognition in bright sunlight when compared with clear lenses. Additionally, the lenses allowed the subjects to alternate fixation between a bright and shaded target at a more rapid rate in bright sunlight as compared with clear lenses. Subjects preferred both the Amber and Gray-Green lenses over clear lenses in the bright and shadowed target conditions. The results of the current study show that Maxsight Amber and Gray-Green lenses provide better contrast discrimination in bright sunlight, better contrast discrimination when alternating between bright and shaded target conditions, better speed of visual recovery in bright sunlight, and better overall visual performance in bright and shaded target conditions compared with clear lenses.

Occlusion properties of prosthetic contact lenses for the treatment of amblyopia.

PubMed

Collins, Randall S; McChesney, Megan E; McCluer, Craig A; Schatz, Martha P

2008-12-01

The efficacy of opaque contact lenses as occlusion therapy for amblyopia has been established in the literature. Prosthetic contact lenses use similar tints to improve cosmesis in scarred or deformed eyes and may be an alternative in occlusion therapy. To test this idea, we determined the degree of vision penalization elicited by prosthetic contact lenses and their effect on peripheral fusion. We tested 19 CIBA Vision DuraSoft 3 Prosthetic soft contact lenses with varying iris prints, underprints, and opaque pupil sizes in 10 volunteers with best-corrected Snellen distance visual acuity of 20/20 or better in each eye. Snellen visual acuity and peripheral fusion using the Worth 4-Dot test at near were measured on each subject wearing each of the 19 lenses. Results were analyzed with 3-factor analysis of variance. Mean visual acuity through the various lenses ranged from 20/79 to 20/620. Eight lenses allowed preservation of peripheral fusion in 50% or more of the subjects tested. Iris print pattern and opaque pupil size were significant factors in determining visual acuity (p < 0.05). Sufficient vision penalization can be achieved to make occlusion with prosthetic contact lenses a viable therapy for amblyopia. The degree of penalization can be varied and different iris print patterns and pupil sizes, using peripheral fusion, can be preserved with some lenses. Prosthetic contact lenses can be more cosmetically appealing and more tolerable than other amblyopia treatment modalities. These factors may improve compliance in occlusion therapy.

Objective Assessment of Ocular Surface Response to Contact Lens Wear in Presbyopic Contact Lens Wearers of Asian Descent.

PubMed

Guillon, Michel; Dumbleton, Kathy; Theodoratos, Panagiotis; Patel, Trisha; Karkkainen, Tom; Moody, Kurt

2018-05-01

Contact lens wearers of Asian descent may be predisposed to experience microtrauma of the ocular surface as a result a thinner post-lens tear film and higher eyelid tension, and these effects would be anticipated to be most marked in an older population. The objective of this study was to quantify the mechanical effects of the study contact lenses on the ocular surface in a population of presbyopic contact lens wearers of Asian descent. Twenty established presbyopic contact lens wearers (hydrogel n=5, none habitual wearers of etafilcon A lenses; silicone hydrogel n=15) of Asian descent were refitted with etafilcon A multifocal daily disposable contact lenses (1-DAY ACUVUE MOIST MULTIFOCAL) for a period of 1 month of daily lens wear. The habitual modalities of wear were 45% daily disposable and 55% planned replacement. Digital photographs of the upper lid margins, nasal and temporal conjunctiva, and superior cornea were taken after 6 hr of wear of the participants' habitual contact lenses, after 1 day without contact lens wear, and after 6 hr of wear of the study contact lenses at the end of the 1-month period. The photographs were masked according to study visit and the staining extent measured using proprietary software. Lid margin staining was significantly lower with the study contact lenses (2.0±1.0 mm) than with the participants' own contact lenses (3.2±3.0 mm) after 6 hr of wear, representing a mean staining decrease of 38% (P=0.010). Lid margin staining after 6 hr of wear of the study contact lenses was not different from that measured after 1 day without contact lenses (P=0.507). Limbal staining was also significantly less with the study contact lenses than with the participants' own contact lenses after 6 hr of wear (P=0.009). There was minimal upper corneal staining, and the degree was similar with the study and habitual lenses. Etafilcon A material, worn under a daily disposable modality, was shown to reduce upper lid margin and limbal staining in presbyopic contact lens wearers of Asian descent compared with the wearers' own contact lenses. Because of the high preponderance of dry eye amongst presbyopes, material selection is of importance and consideration should be given to the lens-ocular surface interaction.

Objective Assessment of Ocular Surface Response to Contact Lens Wear in Presbyopic Contact Lens Wearers of Asian Descent

PubMed Central

Dumbleton, Kathy; Theodoratos, Panagiotis; Patel, Trisha; Karkkainen, Tom; Moody, Kurt

2018-01-01

Introduction: Contact lens wearers of Asian descent may be predisposed to experience microtrauma of the ocular surface as a result a thinner post-lens tear film and higher eyelid tension, and these effects would be anticipated to be most marked in an older population. The objective of this study was to quantify the mechanical effects of the study contact lenses on the ocular surface in a population of presbyopic contact lens wearers of Asian descent. Methods: Twenty established presbyopic contact lens wearers (hydrogel n=5, none habitual wearers of etafilcon A lenses; silicone hydrogel n=15) of Asian descent were refitted with etafilcon A multifocal daily disposable contact lenses (1-DAY ACUVUE MOIST MULTIFOCAL) for a period of 1 month of daily lens wear. The habitual modalities of wear were 45% daily disposable and 55% planned replacement. Digital photographs of the upper lid margins, nasal and temporal conjunctiva, and superior cornea were taken after 6 hr of wear of the participants' habitual contact lenses, after 1 day without contact lens wear, and after 6 hr of wear of the study contact lenses at the end of the 1-month period. The photographs were masked according to study visit and the staining extent measured using proprietary software. Results: Lid margin staining was significantly lower with the study contact lenses (2.0±1.0 mm2) than with the participants' own contact lenses (3.2±3.0 mm2) after 6 hr of wear, representing a mean staining decrease of 38% (P=0.010). Lid margin staining after 6 hr of wear of the study contact lenses was not different from that measured after 1 day without contact lenses (P=0.507). Limbal staining was also significantly less with the study contact lenses than with the participants' own contact lenses after 6 hr of wear (P=0.009). There was minimal upper corneal staining, and the degree was similar with the study and habitual lenses. Conclusions: Etafilcon A material, worn under a daily disposable modality, was shown to reduce upper lid margin and limbal staining in presbyopic contact lens wearers of Asian descent compared with the wearers' own contact lenses. Because of the high preponderance of dry eye amongst presbyopes, material selection is of importance and consideration should be given to the lens–ocular surface interaction. PMID:27755285

Emission-angle and polarization-rotation effects in the lensed CMB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Antony; Hall, Alex; Challinor, Anthony, E-mail: antony@cosmologist.info, E-mail: ahall@roe.ac.uk, E-mail: a.d.challinor@ast.cam.ac.uk

Lensing of the CMB is an important effect, and is usually modelled by remapping the unlensed CMB fields by a lensing deflection. However the lensing deflections also change the photon path so that the emission angle is no longer orthogonal to the background last-scattering surface. We give the first calculation of the emission-angle corrections to the standard lensing approximation from dipole (Doppler) sources for temperature and quadrupole sources for temperature and polarization. We show that while the corrections are negligible for the temperature and E-mode polarization, additional large-scale B-modes are produced with a white spectrum that dominates those from post-Bornmore » field rotation (curl lensing). On large scales about one percent of the total lensing-induced B-mode amplitude is expected to be due to this effect. However, the photon emission angle does remain orthogonal to the perturbed last-scattering surface due to time delay, and half of the large-scale emission-angle B modes cancel with B modes from time delay to give a total contribution of about half a percent. While not important for planned observations, the signal could ultimately limit the ability of delensing to reveal low amplitudes of primordial gravitational waves. We also derive the rotation of polarization due to multiple deflections between emission and observation. The rotation angle is of quadratic order in the deflection angle, and hence negligibly small: polarization typically rotates by less than an arcsecond, orders of magnitude less than a small-scale image rotates due to post-Born field rotation (which is quadratic in the shear). The field-rotation B modes dominate the other effects on small scales.« less

Searching for massive clusters in weak lensing surveys

NASA Astrophysics Data System (ADS)

Hamana, Takashi; Takada, Masahiro; Yoshida, Naoki

2004-05-01

We explore the ability of weak lensing surveys to locate massive clusters. We use both analytic models of dark matter haloes and mock weak lensing surveys generated from a large cosmological N-body simulation. The analytic models describe the average properties of weak lensing haloes and predict the number counts, enabling us to compute an effective survey selection function. We argue that the detectability of massive haloes depends not only on the halo mass but also strongly on the redshift where the halo is located. We test the model prediction for the peak number counts in weak lensing mass maps against mock numerical data, and find that the noise resulting from intrinsic galaxy ellipticities causes a systematic effect which increases the peak counts. We develop a correction scheme for the systematic effect in an empirical manner, and show that, after correction, the model prediction agrees well with the mock data. The mock data is also used to examine the completeness and efficiency of the weak lensing halo search by fully taking into account the noise and the projection effect by large-scale structures. We show that the detection threshold of S/N = 4 ~ 5 gives an optimal balance between completeness and efficiency. Our results suggest that, for a weak lensing survey with a galaxy number density of ng= 30 arcmin-2 with a mean redshift of z= 1, the mean number of haloes which are expected to cause lensing signals above S/N = 4 is Nhalo(S/N > 4) = 37 per 10 deg2, whereas 23 of the haloes are actually detected with S/N > 4, giving the effective completeness as good as 63 per cent. Alternatively, the mean number of peaks in the same area is Npeak= 62 for a detection threshold of S/N = 4. Among the 62 peaks, 23 are caused by haloes with the expected peak height S/N > 4, 13 result from haloes with 3 < S/N < 4 and the remaining 26 peaks are either the false peaks caused by the noise or haloes with a lower expected peak height. Therefore the contamination rate is 44 per cent (this could be an overestimation). Weak lensing surveys thus provide a reasonably efficient way to search for massive clusters.

Effect of Daily Contact Lens Cleaning on Ocular Adverse Events during Extended Wear.

PubMed

Ozkan, Jerome; Rathi, Varsha M; de la Jara, Percy Lazon; Naduvilath, Thomas; Holden, Brien A; Willcox, Mark D P

2015-02-01

The purpose of the study was to assess what effect daily cleaning of contact lenses with a multipurpose disinfection solution (MPDS), during 30 nights extended wear, would have on contact lens-related adverse events. This was a prospective, open-label, randomized, controlled, parallel-group, 3-month clinical study in which 193 participants were dispensed with lotrafilcon A silicone hydrogel lenses for a 30-day extended-wear schedule and with lenses replaced monthly. Participants were randomized to a control or test group. Test subjects were required to remove lenses daily after waking, clean them with the MPDS, and reinsert the lenses. Control subjects wore lenses without removal for 30 days extended wear. Handling-related lens contamination was assessed at the baseline visit. There was no significant difference between the test and control groups for the incidence of significant corneal infiltrative events (1.3 vs. 4.9%, p = 0.368), total corneal infiltrative events (2.6 vs. 4.9%, p = 0.682), or mechanical events (1.3 vs. 2.5%, p = 1.00). The test group had greater corneal staining (p < 0.047) and fewer mucin balls (p = 0.033). Handling-related lens contamination (unworn lenses) resulted in isolation of Gram-positive bacteria from 92.5% of test lenses compared with 87.5% of control lenses (p = 0.712). Gram-negative bacteria were isolated from 5% of test subjects compared with 2.5% of control subjects (p = 1.00). Fungus was isolated from 2.5% of subjects in both the test and control groups (p = 1.00). The intervention of daily morning cleaning of the lens surface with an MPDS during extended wear did not significantly influence the incidence of adverse events.

Weak lensing of the Lyman α forest

NASA Astrophysics Data System (ADS)

Croft, Rupert A. C.; Romeo, Alessandro; Metcalf, R. Benton

2018-06-01

The angular positions of quasars are deflected by the gravitational lensing effect of foreground matter. The Lyman α (Lyα) forest seen in the spectra of these quasars is therefore also lensed. We propose that the signature of weak gravitational lensing of the Lyα forest could be measured using similar techniques that have been applied to the lensed cosmic microwave background (CMB), and which have also been proposed for application to spectral data from 21-cm radio telescopes. As with 21-cm data, the forest has the advantage of spectral information, potentially yielding many lensed `slices' at different redshifts. We perform an illustrative idealized test, generating a high-resolution angular grid of quasars (of order arcminute separation), and lensing the Lyα forest spectra at redshifts z = 2-3 using a foreground density field. We find that standard quadratic estimators can be used to reconstruct images of the foreground mass distribution at z ˜ 1. There currently exists a wealth of Lyα forest data from quasar and galaxy spectral surveys, with smaller sightline separations expected in the future. Lyα forest lensing is sensitive to the foreground mass distribution at redshifts intermediate between CMB lensing and galaxy shear, and avoids the difficulties of shape measurement associated with the latter. With further refinement and application of mass reconstruction techniques, weak gravitational lensing of the high-redshift Lyα forest may become a useful new cosmological probe.

The merging cluster Abell 1758: an optical and dynamical view

NASA Astrophysics Data System (ADS)

Monteiro-Oliveira, Rogerio; Serra Cypriano, Eduardo; Machado, Rubens; Lima Neto, Gastao B.

2015-08-01

The galaxy cluster Abell 1758-North (z=0.28) is a binary system composed by the sub-structures NW and NE. This is supposed to be a post-merging cluster due to observed detachment between the NE BCG and the respective X-ray emitting hot gas clump in a scenario very close to the famous Bullet Cluster. On the other hand, the projected position of the NW BCG coincides with the local hot gas peak. This system was been targeted previously by several studies, using multiple wavelengths and techniques, but there is still no clear picture of the scenario that could have caused this unusual configuration. To help solving this complex puzzle we added some pieces: firstly, we have used deep B, RC and z' Subaru images to perform both weak lensing shear and magnification analysis of A1758 (including here the South component that is not in interaction with A1758-North) modeling each sub-clump as an NFW profile in order to constrain masses and its center positions through MCMC methods; the second piece is the dynamical analysis using radial velocities available in the literature (143) plus new Gemini-GMOS/N measurements (68 new redshifts).From weak lensing we found that independent shear and magnification mass determinations are in excellent agreement between them and combining both we could reduce mass error bar by ~30% compared to shear alone. By combining this two weak-lensing probes we found that the position of both Northern BCGs are consistent with the masses centers within 2σ and and the NE hot gas peak to be offseted of the respective mass peak (M200=5.5 X 1014 M⊙) with very high significance. The most massive structure is NW (M200=7.95 X 1014 M⊙ ) where we observed no detachment between gas, DM and BCG.We have calculated a low line-of-sight velocity difference (<300 km/s) between A1758 NW and NE. We have combined it with the projected velocity of 1600 km/s which was estimated by previous X-ray analysis (David & Kempner 2004) and we have obtained a small angle between the plane of collision and the sky (<40 degrees). Dynamic modeling shows that the point of maximum approximation taken place 0.55 Gyr ago, pointing Abell 1758-North as a young merger cluster.

Features of optical surfaces of multifocal diffractive-refractive eye lenses

NASA Astrophysics Data System (ADS)

Lenkova, G. A.

2017-09-01

This paper considers shape features of the surface structures of multifocal intraocular lenses (IOLs), which, unlike bifocal IOLs, generate additional foci or extends the depth of focus, which not only corrects near and far vision but also provides good vision at intermediate distances. Expansion of the field of clear vision is achieved due to the effects of diffraction, interference, and refraction (change in the radius of curvature of the lens surface). The optical characteristics of the most famous multifocal IOLs (trifocal and quadrafocal lenses and lenses with extended focal area) are given.

VizieR Online Data Catalog: The SEGUE K giant survey. III. Galactic halo (Janesh+, 2016)

NASA Astrophysics Data System (ADS)

Janesh, W.; Morrison, H. L.; Ma, Z.; Rockosi, C.; Starkenburg, E.; Xue, X. X.; Rix, H.-W.; Harding, P.; Beers, T. C.; Johnson, J.; Lee, Y. S.; Schneider, D. P.

2016-03-01

We statistically quantify the amount of substructure in the Milky Way stellar halo using a sample of 4568 halo K giant stars at Galactocentric distances ranging over 5-125kpc. These stars have been selected photometrically and confirmed spectroscopically as K giants from the Sloan Digital Sky Survey's Sloan Extension for Galactic Understanding and Exploration (SEGUE) project. Using a position-velocity clustering estimator (the 4distance) and a model of a smooth stellar halo, we quantify the amount of substructure in the halo, divided by distance and metallicity. Overall, we find that the halo as a whole is highly structured. We also confirm earlier work using blue horizontal branch (BHB) stars which showed that there is an increasing amount of substructure with increasing Galactocentric radius, and additionally find that the amount of substructure in the halo increases with increasing metallicity. Comparing to resampled BHB stars, we find that K giants and BHBs have similar amounts of substructure over equivalent ranges of Galactocentric radius. Using a friends-of-friends algorithm to identify members of individual groups, we find that a large fraction (~33%) of grouped stars are associated with Sgr, and identify stars belonging to other halo star streams: the Orphan Stream, the Cetus Polar Stream, and others, including previously unknown substructures. A large fraction of sample K giants (more than 50%) are not grouped into any substructure. We find also that the Sgr stream strongly dominates groups in the outer halo for all except the most metal-poor stars, and suggest that this is the source of the increase of substructure with Galactocentric radius and metallicity. (2 data files).

Efficacy and durability of ultraviolet tints in CR-39 ophthalmic lenses.

PubMed

Lee, D Y; Brown, W L; Trachimowicz, R

1997-11-01

Ocular protection from solar ultraviolet (UV) radiation has been emphasized in recent years as a result of the thinning of the ozone layer in the atmosphere. The purpose of this study was to evaluate the absorptive properties of UV tints in CR-39 lenses. We used a spectrophotometer to measure the UV transmittance of three groups of UV tinted CR-39 lenses, including (1) lenses tinted by local optical laboratories: (2) lenses tinted by us, using commercially available dyes: and (3) stock UV lenses that have UV absorptive molecules throughout the lens. We also tested the durability of these tints to daily washing/drying by measuring their UV transmittance characteristics at 3, 6, and 12 months. All the tested lenses absorbed all of the UV-B and at least 99% of UV-A. The durability of these UV tints when exposed to daily washing/drying was excellent: all lenses continued to absorb all of the UV-B and at least 99% of UV-A after 1 year. These data suggest that UV tinted CR-39 lenses provide protection against UV radiation that meets the ANSI Z80.3-1996 Standard for non-prescription sunglasses and fashion eyewear. Furthermore, normal daily washing/drying for 1 year does not cause a significant decrease in the protective effect of the UV tint.

Optical performance of random anti-reflection structured surfaces (rARSS) on spherical lenses

NASA Astrophysics Data System (ADS)

Taylor, Courtney D.

Random anti-reflection structured surfaces (rARSS) have been reported to improve transmittance of optical-grade fused silica planar substrates to values greater than 99%. These textures are fabricated directly on the substrates using reactive-ion/inductively-coupled plasma etching (RIE/ICP) techniques, and often result in transmitted spectra with no measurable interference effects (fringes) for a wide range of wavelengths. The RIE/ICP processes used in the fabrication process to etch the rARSS is anisotropic and thus well suited for planar components. The improvement in spectral transmission has been found to be independent of optical incidence angles for values from 0° to +/-30°. Qualifying and quantifying the rARSS performance on curved substrates, such as convex lenses, is required to optimize the fabrication of the desired AR effect on optical-power elements. In this work, rARSS was fabricated on fused silica plano-convex (PCX) and plano-concave (PCV) lenses using a planar-substrate optimized RIE process to maximize optical transmission in the range from 500 to 1100 nm. An additional set of lenses were etched in a non-optimized ICP process to provide additional comparisons. Results are presented from optical transmission and beam propagation tests (optimized lenses only) of rARSS lenses for both TE and TM incident polarizations at a wavelength of 633 nm and over a 70° full field of view in both singlet and doublet configurations. These results suggest optimization of the fabrication process is not required, mainly due to the wide angle-of-incidence AR tolerance performance of the rARSS lenses. Non-optimized recipe lenses showed low transmission enhancement, and confirmed the need to optimized etch recipes prior to process transfer of PCX/PCV lenses. Beam propagation tests indicated no major beam degradation through the optimized lens elements. Scanning electron microscopy (SEM) images confirmed different structure between optimized and non-optimized samples. SEM images also indicated isotropically-oriented surface structures on both types of lenses.

User's Guide for ENSAERO_FE Parallel Finite Element Solver

NASA Technical Reports Server (NTRS)

Eldred, Lloyd B.; Guruswamy, Guru P.

1999-01-01

A high fidelity parallel static structural analysis capability is created and interfaced to the multidisciplinary analysis package ENSAERO-MPI of Ames Research Center. This new module replaces ENSAERO's lower fidelity simple finite element and modal modules. Full aircraft structures may be more accurately modeled using the new finite element capability. Parallel computation is performed by breaking the full structure into multiple substructures. This approach is conceptually similar to ENSAERO's multizonal fluid analysis capability. The new substructure code is used to solve the structural finite element equations for each substructure in parallel. NASTRANKOSMIC is utilized as a front end for this code. Its full library of elements can be used to create an accurate and realistic aircraft model. It is used to create the stiffness matrices for each substructure. The new parallel code then uses an iterative preconditioned conjugate gradient method to solve the global structural equations for the substructure boundary nodes.

Cosmological test using strong gravitational lensing systems

NASA Astrophysics Data System (ADS)

Yuan, C. C.; Wang, F. Y.

2015-09-01

As one of the probes of universe, strong gravitational lensing systems allow us to compare different cosmological models and constrain vital cosmological parameters. This purpose can be reached from the dynamic and geometry properties of strong gravitational lensing systems, for instance, time-delay Δτ of images, the velocity dispersion σ of the lensing galaxies and the combination of these two effects, Δτ/σ2. In this paper, in order to carry out one-on-one comparisons between ΛCDM universe and Rh = ct universe, we use a sample containing 36 strong lensing systems with the measurement of velocity dispersion from the Sloan Lens Advanced Camera for Surveys (SLACS) and Lens Structure and Dynamic survey (LSD) survey. Concerning the time-delay effect, 12 two-image lensing systems with Δτ are also used. In addition, Monte Carlo simulations are used to compare the efficiency of the three methods as mentioned above. From simulations, we estimate the number of lenses required to rule out one model at the 99.7 per cent confidence level. Comparing with constraints from Δτ and the velocity dispersion σ, we find that using Δτ/σ2 can improve the discrimination between cosmological models. Despite the independence tests of these methods reveal a correlation between Δτ/σ2 and σ, Δτ/σ2 could be considered as an improved method of σ if more data samples are available.

A Laboratory Assessment of Factors That Affect Bacterial Adhesion to Contact Lenses

PubMed Central

Dutta, Debarun; Willcox, Mark DP

2013-01-01

Adhesion of pathogenic microbes, particularly bacteria, to contact lenses is implicated in contact lens related microbial adverse events. Various in vitro conditions such as type of bacteria, the size of initial inoculum, contact lens material, nutritional content of media, and incubation period can influence bacterial adhesion to contact lenses and the current study investigated the effect of these conditions on bacterial adhesion to contact lenses. There was no significant difference in numbers of bacteria that adhered to hydrogel etafilcon A or silicone hydrogel senofilcon A contact lenses. Pseudomonas aeruginosa adhered in higher numbers compared to Staphylococcus aureus. Within a genera/species, adhesion of different bacterial strains did not differ appreciably. The size of initial inoculum, nutritional content of media, and incubation period played significant roles in bacterial adhesion to lenses. A set of in vitro assay conditions to help standardize adhesion between studies have been recommended. PMID:24833224

A measurement of CMB cluster lensing with SPT and DES year 1 data

NASA Astrophysics Data System (ADS)

Baxter, E. J.; Raghunathan, S.; Crawford, T. M.; Fosalba, P.; Hou, Z.; Holder, G. P.; Omori, Y.; Patil, S.; Rozo, E.; Abbott, T. M. C.; Annis, J.; Aylor, K.; Benoit-Lévy, A.; Benson, B. A.; Bertin, E.; Bleem, L.; Buckley-Geer, E.; Burke, D. L.; Carlstrom, J.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; Chang, C. L.; Cho, H.-M.; Crites, A. T.; Crocce, M.; Cunha, C. E.; da Costa, L. N.; D'Andrea, C. B.; Davis, C.; de Haan, T.; Desai, S.; Dietrich, J. P.; Dobbs, M. A.; Dodelson, S.; Doel, P.; Drlica-Wagner, A.; Estrada, J.; Everett, W. B.; Fausti Neto, A.; Flaugher, B.; Frieman, J.; García-Bellido, J.; George, E. M.; Gaztanaga, E.; Giannantonio, T.; Gruen, D.; Gruendl, R. A.; Gschwend, J.; Gutierrez, G.; Halverson, N. W.; Harrington, N. L.; Hartley, W. G.; Holzapfel, W. L.; Honscheid, K.; Hrubes, J. D.; Jain, B.; James, D. J.; Jarvis, M.; Jeltema, T.; Knox, L.; Krause, E.; Kuehn, K.; Kuhlmann, S.; Kuropatkin, N.; Lahav, O.; Lee, A. T.; Leitch, E. M.; Li, T. S.; Lima, M.; Luong-Van, D.; Manzotti, A.; March, M.; Marrone, D. P.; Marshall, J. L.; Martini, P.; McMahon, J. J.; Melchior, P.; Menanteau, F.; Meyer, S. S.; Miller, C. J.; Miquel, R.; Mocanu, L. M.; Mohr, J. J.; Natoli, T.; Nord, B.; Ogando, R. L. C.; Padin, S.; Plazas, A. A.; Pryke, C.; Rapetti, D.; Reichardt, C. L.; Romer, A. K.; Roodman, A.; Ruhl, J. E.; Rykoff, E.; Sako, M.; Sanchez, E.; Sayre, J. T.; Scarpine, V.; Schaffer, K. K.; Schindler, R.; Schubnell, M.; Sevilla-Noarbe, I.; Shirokoff, E.; Smith, M.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Staniszewski, Z.; Stark, A.; Story, K.; Suchyta, E.; Tarle, G.; Thomas, D.; Troxel, M. A.; Vanderlinde, K.; Vieira, J. D.; Walker, A. R.; Williamson, R.; Zhang, Y.; Zuntz, J.

2018-05-01

Clusters of galaxies gravitationally lens the cosmic microwave background (CMB) radiation, resulting in a distinct imprint in the CMB on arcminute scales. Measurement of this effect offers a promising way to constrain the masses of galaxy clusters, particularly those at high redshift. We use CMB maps from the South Pole Telescope Sunyaev-Zel'dovich (SZ) survey to measure the CMB lensing signal around galaxy clusters identified in optical imaging from first year observations of the Dark Energy Survey. The cluster catalogue used in this analysis contains 3697 members with mean redshift of \\bar{z} = 0.45. We detect lensing of the CMB by the galaxy clusters at 8.1σ significance. Using the measured lensing signal, we constrain the amplitude of the relation between cluster mass and optical richness to roughly 17 {per cent} precision, finding good agreement with recent constraints obtained with galaxy lensing. The error budget is dominated by statistical noise but includes significant contributions from systematic biases due to the thermal SZ effect and cluster miscentring.

A Measurement of CMB Cluster Lensing with SPT and DES Year 1 Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baxter, E.J.; et al.

2017-08-03

Clusters of galaxies gravitationally lens the cosmic microwave background (CMB) radiation, resulting in a distinct imprint in the CMB on arcminute scales. Measurement of this effect offers a promising way to constrain the masses of galaxy clusters, particularly those at high redshift. We use CMB maps from the South Pole Telescope Sunyaev-Zel'dovich (SZ) survey to measure the CMB lensing signal around galaxy clusters identified in optical imaging from first year observations of the Dark Energy Survey. We detect lensing of the CMB by the galaxy clusters at 6.5more » $$\\sigma$$ significance. Using the measured lensing signal, we constrain the amplitude of the relation between cluster mass and optical richness to roughly $$20\\%$$ precision, finding good agreement with recent constraints obtained with galaxy lensing. The error budget is dominated by statistical noise but includes significant contributions from systematic biases due to the thermal SZ effect and cluster miscentering.« less

Resolution of the apparent discrepancy between the number of massive subhaloes in Abell 2744 and ΛCDM

NASA Astrophysics Data System (ADS)

Mao, Tian-Xiang; Wang, Jie; Frenk, Carlos S.; Gao, Liang; Li, Ran; Wang, Qiao; Cao, Xiaoyue; Li, Ming

2018-07-01

Schwinn et al. have recently compared the abundance and distribution of massive substructures identified in a gravitational lensing analysis of Abell 2744 by Jauzac et al. and N-body simulation, and found no cluster in Lambda cold dark matter (ΛCDM) simulation that is similar to Abell 2744. Schwinn et al. identified the measured projected aperture masses with the actual masses associated with subhaloes in the Millenium XXL N-body simulation. We have used the high-resolution Phoenix cluster simulations to show that such an identification is incorrect: the aperture mass is dominated by mass in the body of the cluster that happens to be projected along the line of sight to the subhalo. This enhancement varies from factors of a few to factors of more than 100, particularly for subhaloes projected near the centre of the cluster. We calculate aperture masses for subhaloes in our simulation and compare them to the measurements for Abell 2744. We find that the data for Abell 2744 are in excellent agreement with the matched predictions from ΛCDM. We provide further predictions for aperture mass functions of subhaloes in idealized surveys with varying mass detection thresholds.

Weak Gravitational Lensing

NASA Astrophysics Data System (ADS)

Pires, Sandrine; Starck, Jean-Luc; Leonard, Adrienne; Réfrégier, Alexandre

2012-03-01

This chapter reviews the data mining methods recently developed to solve standard data problems in weak gravitational lensing. We detail the different steps of the weak lensing data analysis along with the different techniques dedicated to these applications. An overview of the different techniques currently used will be given along with future prospects. Until about 30 years ago, astronomers thought that the Universe was composed almost entirely of ordinary matter: protons, neutrons, electrons, and atoms. The field of weak lensing has been motivated by the observations made in the last decades showing that visible matter represents only about 4-5% of the Universe (see Figure 14.1). Currently, the majority of the Universe is thought to be dark, that is, does not emit electromagnetic radiation. The Universe is thought to be mostly composed of an invisible, pressure less matter - potentially relic from higher energy theories - called "dark matter" (20-21%) and by an even more mysterious term, described in Einstein equations as a vacuum energy density, called "dark energy" (70%). This "dark" Universe is not well described or even understood; its presence is inferred indirectly from its gravitational effects, both on the motions of astronomical objects and on light propagation. So this point could be the next breakthrough in cosmology. Today's cosmology is based on a cosmological model that contains various parameters that need to be determined precisely, such as the matter density parameter Omega_m or the dark energy density parameter Omega_lambda. Weak gravitational lensing is believed to be the most promising tool to understand the nature of dark matter and to constrain the cosmological parameters used to describe the Universe because it provides a method to directly map the distribution of dark matter (see [1,6,60,63,70]). From this dark matter distribution, the nature of dark matter can be better understood and better constraints can be placed on dark energy, which affects the evolution of structures. Gravitational lensing is the process by which light from distant galaxies is bent by the gravity of intervening mass in the Universe as it travels toward us. This bending causes the images of background galaxies to appear slightly distorted, and can be used to extract important cosmological information. In the beginning of the twentieth century, A. Einstein predicted that massive bodies could be seen as gravitational lenses that bend the path of light rays by creating a local curvature in space time. One of the first confirmations of Einstein's new theory was the observation during the 1919 solar eclipse of the deflection of light from distant stars by the sun. Since then, a wide range of lensing phenomena have been detected. The gravitational deflection of light by mass concentrations along light paths produces magnification, multiplication, and distortion of images. These lensing effects are illustrated by Figure 14.2, which shows one of the strongest lenses observed: Abell 2218, a very massive and distant cluster of galaxies in the constellation Draco. The observed gravitational arcs are actually the magnified and strongly distorted images of galaxies that are about 10 times more distant than the cluster itself. These strong gravitational lensing effects are very impressive but they are very rare. Far more prevalent are weak gravitational lensing effects, which we consider in this chapter, and in which the induced distortion in galaxy images is much weaker. These gravitational lensing effects are now widely used, but the amplitude of the weak lensing signal is so weak that its detection relies on the accuracy of the techniques used to analyze the data. Future weak lensing surveys are already planned in order to cover a large fraction of the sky with high accuracy, such as Euclid [68]. However, improving accuracy also places greater demands on the methods used to extract the available information.

Substructure System Identification for Finite Element Model Updating

NASA Technical Reports Server (NTRS)

Craig, Roy R., Jr.; Blades, Eric L.

1997-01-01

This report summarizes research conducted under a NASA grant on the topic 'Substructure System Identification for Finite Element Model Updating.' The research concerns ongoing development of the Substructure System Identification Algorithm (SSID Algorithm), a system identification algorithm that can be used to obtain mathematical models of substructures, like Space Shuttle payloads. In the present study, particular attention was given to the following topics: making the algorithm robust to noisy test data, extending the algorithm to accept experimental FRF data that covers a broad frequency bandwidth, and developing a test analytical model (TAM) for use in relating test data to reduced-order finite element models.

Jet Substructure at the Large Hadron Collider : Experimental Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Asquith, Lily; Campanelli, Mario; Delitzsch, Chris

Jet substructure has emerged to play a central role at the Large Hadron Collider (LHC), where it has provided numerous innovative new ways to search for new physics and to probe the Standard Model, particularly in extreme regions of phase space. In this article we focus on a review of the development and use of state-of-the-art jet substructure techniques by the ATLAS and CMS experiments. ALICE and LHCb have been probing fragmentation functions since the start of the LHC and have also recently started studying other jet substructure techniques. It is likely that in the near future all LHC collaborationsmore » will make significant use of jet substructure and grooming techniques. Much of the work in this field in recent years has been galvanized by the Boost Workshop Series, which continues to inspire fruitful collaborations between experimentalists and theorists. We hope that this review will prove a useful introduction and reference to experimental aspects of jet substructure at the LHC. A companion overview of recent progress in theory and machine learning approaches is given in 1709.04464, the complete review will be submitted to Reviews of Modern Physics.« less

Salicylate inhibition of acanthamoebal attachment to contact lenses.

PubMed

Beattie, Tara K; Tomlinson, Alan; Seal, David V; McFadyen, Angus K

2011-12-01

Sodium salicylate has shown potential as a component of contact lens care solutions designed to reduce Acanthamoebal attachment to contact lenses. This study determined the minimum effective concentration required to significantly reduce amoebal attachment. Different concentrations of sodium salicylate (10, 15, and 20 mM) were applied during exposure of unworn or bacterial biofilm-coated hydrogel contact lenses to Acanthamoeba castellanii trophozoites. Salicylate was applied at stage 1 intervention during biofilm formation on lenses, at stage 2 intervention during amoebal exposure, or at both stages. A significant reduction in amoebal attachment was achieved when 10 mM salicylate was included during stage 1 alone; however, 15 mM was required for stage 2 intervention to significantly reduce attachment to clean or biofilm-coated lenses. For stages 1 and 2 combined intervention, 10 mM sodium salicylate produced a significant reduction in amoebal attachment. In situ, within a contact lens case, biofilm formation and amoebal attachment would occur concurrently; therefore, stages 1 and 2 intervention would be closest to the real-life situation, thus indicating that 10 mM of salicylate would be an effective minimum concentration for reducing amoebal attachment to hydrogel contact lenses. Inclusion of components in contact lens care solution, such as sodium salicylate, which reduce Acanthamoebal attachment, has the potential to enhance effectiveness, particularly where amoebicidal efficacy may be limited, thus reducing the risk of contact lens-associated Acanthamoebal infection.

Opposite Effects of Glucagon and Insulin on Compensation for Spectacle Lenses in Chicks

PubMed Central

Zhu, Xiaoying; Wallman, Josh

2009-01-01

Purpose Chick eyes compensate for defocus imposed by positive or negative spectacle lenses. Glucagon may signal the sign of defocus. Do insulin (or IGF-1) and glucagon act oppositely in controlling eye growth, as they do in metabolic pathways and in control of retinal neurogenesis? Methods Chicks, wearing either lenses or diffusers or neither over both eyes, were injected with glucagon, a glucagon antagonist, insulin, or IGF-1 in one eye (saline in other eye). Alternatively, chicks without lenses received insulin plus glucagon in one eye, and either glucagon or insulin in the fellow eye. Ocular dimensions, refractive errors and glycosaminoglycan synthesis were measured over 2-4 days. Results Glucagon attenuated the myopic response to negative lenses or diffusers by slowing ocular elongation and thickening the choroid; in contrast, with positive lenses, it increased ocular elongation to normal levels and reduced choroidal thickening, as did a glucagon antagonist. Insulin prevented the hyperopic response to positive lenses by speeding ocular elongation and thinning the choroid. In eyes without lenses, both insulin and IGF-1 speeded, and glucagon slowed, ocular elongation, but either glucagon or insulin increased the rate of thickening of the crystalline lens. When injected together, insulin blocked choroidal thickening by glucagon, at a dose that did not, by itself, thin the choroid. Conclusions Glucagon and insulin (or IGF-1) cause generally opposite modulations of eye-growth, with glucagon mostly increasing choroidal thickness and insulin mostly increasing ocular elongation. These effects are mutually inhibitory and depend on the visual input. PMID:18791176

Broad spectrum antimicrobial activity of melimine covalently bound to contact lenses.

PubMed

Dutta, Debarun; Cole, Nerida; Kumar, Naresh; Willcox, Mark D P

2013-01-07

To develop a stable antimicrobial contact lens, which is effective against the International Organization for Standardization (ISO) panel microorganisms, Acanthamoeba castellanii and drug resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. Melimine was covalently incorporated into etafilcon A lenses. The amount of peptide present on the lens surface was quantified using amino acid analysis. After coating, the heat stability (121°C), lens surface hydrophobicity (by captive bubble), and in vitro cytotoxicity to mouse L929 cells of the lenses were investigated. Antimicrobial activity against the micro-organisms was evaluated by viable plate count and fluorescence microscopy, measuring the proportion of cell death compared with control lenses with no melimine. The most effective concentration was determined to be 152 ± 44 μg lens(-1) melimine on the lens surface. After coating, lenses were relatively hydrophilic and were nontoxic to mammalian cells. The activity remained high after autoclaving (e.g., 3.1, 3.9, 1.2, and 1.0 log inhibition against P. aeruginosa, S. aureus, A. castellanii, and Fusarium solani, respectively). Fluorescence microscopy confirmed significantly reduced (P < 0.001) adhesion of viable bacteria to melimine contact lenses. Viable count confirmed that lenses were active against all the bacteria and fungi from the ISO panel, Acanthamoeba and gave at least 2 log inhibition against all the multidrug resistant S. aureus and P. aeruginosa strains. Melimine may offer excellent potential for development as a broad spectrum antimicrobial coating for contact lenses, showing activity against all the bacterial and fungal ISO panel microorganisms, Acanthamoeba, and antibiotic resistant strains of P. aeruginosa and S. aureus.

Magnification of photometric LRGs by foreground LRGs and clusters in the Sloan Digital Sky Survey

NASA Astrophysics Data System (ADS)

Bauer, Anne H.; Gaztañaga, Enrique; Martí, Pol; Miquel, Ramon

2014-06-01

The magnification effect of gravitational lensing is a powerful probe of the distribution of matter in the universe, yet it is frequently overlooked due to the fact that its signal-to-noise ratio is smaller than that of lensing shear. Because its systematic errors are quite different from those of shear, magnification is nevertheless an important approach with which to study the distribution of large-scale structure. We present lensing mass profiles of spectroscopic luminous red galaxies (LRGs) and galaxy clusters determined through measurements of the weak lensing magnification of photometric LRGs in their background. We measure the change in detected galaxy counts as well as the increased average galaxy flux behind the lenses. In addition, we examine the average change in source colour due to extinction by dust in the lenses. By simultaneously fitting these three probes we constrain the mass profiles and dust-to-mass ratios of the lenses in six bins of lens richness. For each richness bin we fit a Navarro-Frenk-White halo mass, brightest cluster galaxy mass, second halo term, and dust-to-mass ratio. The resulting mass-richness relation is consistent with previous analyses of the catalogues, and limits on the dust-to-mass ratio in the lenses are in agreement with expectations. We explore the effects of including the (low signal-to-noise ratio) flux magnification and reddening measurements in the analysis compared to using only the counts magnification data; the additional probes significantly improve the agreement between our measured mass-richness relation and previous results.

Optimization design of periscope type 3X zoom lens design for a five megapixel cellphone camera

NASA Astrophysics Data System (ADS)

Sun, Wen-Shing; Tien, Chuen-Lin; Pan, Jui-Wen; Chao, Yu-Hao; Chu, Pu-Yi

2016-11-01

This paper presents a periscope type 3X zoom lenses design for a five megapixel cellphone camera. The configuration of optical system uses the right angle prism in front of the zoom lenses to change the optical path rotated by a 90° angle resulting in the zoom lenses length of 6 mm. The zoom lenses can be embedded in mobile phone with a thickness of 6 mm. The zoom lenses have three groups with six elements. The half field of view is varied from 30° to 10.89°, the effective focal length is adjusted from 3.142 mm to 9.426 mm, and the F-number is changed from 2.8 to 5.13.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, B.; Kantowski, R.; Dai, X.

We compute time delays for gravitational lensing in a flat {Lambda} dominated cold dark matter Swiss cheese universe. We assume a primary and secondary pair of light rays are deflected by a single point mass condensation described by a Kottler metric (Schwarzschild with {Lambda}) embedded in an otherwise homogeneous cosmology. We find that the cosmological constant's effect on the difference in arrival times is nonlinear and at most around 0.002% for a large cluster lens; however, we find differences from time delays predicted by conventional linear lensing theory that can reach {approx}4% for these large lenses. The differences in predictedmore » delay times are due to the failure of conventional lensing to incorporate the lensing mass into the mean mass density of the universe.« less

Optimization of ceragenins for prevention of bacterial colonization of hydrogel contact lenses.

PubMed

Gu, Xiaobo; Jennings, Jacob D; Snarr, Jason; Chaudhary, Vinod; Pollard, Jacob E; Savage, Paul B

2013-09-17

We provided contact lens hydrogels with an antibacterial innate immune function using nonpeptide mimics of endogenous antimicrobial peptides. Antimicrobial peptide mimics, ceragenins, were prepared for either covalent attachment to hydrogels or for controlled elution from lenses. The lipophilicity of the ceragenins was varied incrementally to provide differing levels of association with hydrophobic domains in lenses. Ceragenin-containing lenses were challenged repeatedly with Staphylococcus aureus or Pseudomonas aeruginosa in nutrient media. Bacterial growth and biofilm formation on lenses were quantified. A ceragenin covalently fixed in lenses effectively inhibited S. aureus biofilm formation on lenses in 10% tryptic soy broth (approximately 3-log reduction), but did not reduce biofilm formation in 100% tryptic soy broth. Ceragenins designed to elute from lenses were incorporated at 1% relative to the dry weight of the lenses. The ceragenin with the optimal lipid content, CSA-138, prevented bacterial colonization of lenses for 15 days with P. aeruginosa and for 30 days with S. aureus (daily exchange of growth media and reinoculation with 10⁶ CFU). Measurement of CSA-138 elution showed that concentrations of the ceragenin never exceeded 5 μg/mL in a 24-hour period and that after 4 days of elution, concentrations dropped to <0.5 μg/mL, while maintaining antibacterial activity. Ceragenin CSA-138 appears well suited for providing an innate immune-like function to abiotic hydrogel contact lenses for extended periods of time. Elution of even low concentrations of CSA-138 (<0.5 μg) is sufficient to eliminate inocula of 10⁶ CFU of S. aureus and P. aeruginosa.

Accommodation and the Visual Regulation of Refractive State in Marmosets

PubMed Central

Troilo, David; Totonelly, Kristen; Harb, Elise

2009-01-01

Purpose To determine the effects of imposed anisometropic retinal defocus on accommodation, ocular growth, and refractive state changes in marmosets. Methods Marmosets were raised with extended-wear soft contact lenses for an average duration of 10 wks beginning at an average age of 76 d. Experimental animals wore either a positive or negative contact lens over one eye and a plano lens or no lens over the other. Another group wore binocular lenses of equal magnitude but opposite sign. Untreated marmosets served as controls and three wore plano lenses monocularly. Cycloplegic refractive state, corneal curvature, and vitreous chamber depth were measured before, during, and after the period of lens wear. To investigate the accommodative response, the effective refractive state was measured through each anisometropic condition at varying accommodative stimuli positions using an infrared refractometer. Results Eye growth and refractive state are significantly correlated with the sign and power of the contact lens worn. The eyes of marmosets reared with monocular negative power lenses had longer vitreous chambers and were myopic relative to contralateral control eyes (p<0.01). Monocular positive power lenses produced a significant reduction in vitreous chamber depth and hyperopia relative to the contralateral control eyes (p<0.05). In marmosets reared binocularly with lenses of opposite sign, we found larger interocular differences in vitreous chamber depths and refractive state (p<0.001). Accommodation influences the defocus experienced through the lenses, however, the mean effective refractive state was still hyperopia in the negative-lens-treated eyes and myopia in the positive-lens-treated eyes. Conclusions Imposed anisometropia effectively alters marmoset eye growth and refractive state to compensate for the imposed defocus. The response to imposed hyperopia is larger and faster than the response to imposed myopia. The pattern of accommodation under imposed anisometropia produces effective refractive states that are consistent with the changes in eye growth and refractive state observed. PMID:19104464

Evolution of the degree of substructures in simulated galaxy clusters

NASA Astrophysics Data System (ADS)

De Boni, Cristiano; Böhringer, Hans; Chon, Gayoung; Dolag, Klaus

2018-05-01

We study the evolution of substructure in the mass distribution with mass, redshift and radius in a sample of simulated galaxy clusters. The sample, containing 1226 objects, spans the mass range M200 = 1014 - 1.74 × 1015 M⊙ h-1 in six redshift bins from z = 0 to z = 1.179. We consider three different diagnostics: 1) subhalos identified with SUBFIND; 2) overdense regions localized by dividing the cluster into octants; 3) offset between the potential minimum and the center of mass. The octant analysis is a new method that we introduce in this work. We find that none of the diagnostics indicate a correlation between the mass of the cluster and the fraction of substructures. On the other hand, all the diagnostics suggest an evolution of substructures with redshift. For SUBFIND halos, the mass fraction is constant with redshift at Rvir, but shows a mild evolution at R200 and R500. Also, the fraction of clusters with at least a subhalo more massive than one thirtieth of the total mass is less than 20%. Our new method based on the octants returns a mass fraction in substructures which has a strong evolution with redshift at all radii. The offsets also evolve strongly with redshift. We also find a strong correlation for individual clusters between the offset and the fraction of substructures identified with the octant analysis. Our work puts strong constraints on the amount of substructures we expect to find in galaxy clusters and on their evolution with redshift.

J0454-0309: evidence of a strong lensing fossil group falling into a poor galaxy cluster

NASA Astrophysics Data System (ADS)

Schirmer, M.; Suyu, S.; Schrabback, T.; Hildebrandt, H.; Erben, T.; Halkola, A.

2010-05-01

Aims: We have discovered a strong lensing fossil group (J0454) projected near the well-studied cluster MS0451-0305. Using the large amount of available archival data, we compare J0454 to normal groups and clusters. A highly asymmetric image configuration of the strong lens enables us to study the substructure of the system. Methods: We used multicolour Subaru/Suprime-Cam and CFHT/Megaprime imaging, together with Keck spectroscopy to identify member galaxies. A VLT/FORS2 spectrum was taken to determine the redshifts of the brightest elliptical and the lensed arc. Using HST/ACS images, we determined the group's weak lensing signal and modelled the strong lens system. This is the first time that a fossil group is analysed with lensing methods. The X-ray luminosity and temperature were derived from XMM-Newton data. Results: J0454 is located at z = 0.26, with a gap of 2.5 mag between the brightest and second brightest galaxies within half the virial radius. Outside a radius of 1.5 Mpc, we find two filaments extending over 4 Mpc, and within we identify 31 members spectroscopically and 33 via the red sequence with i < 22 mag. They segregate into spirals (σ_v = 590 km s-1) and a central concentration of ellipticals (σ_v = 480 km s-1), establishing a morphology-density relation. Weak lensing and cluster richness relations yield consistent values of r200 = 810-850 kpc and M200 = (0.75-0.90) × 1014 M_⊙. The brightest group galaxy (BGG) is inconsistent with the dynamic centre of J0454. It strongly lenses a galaxy at z = 2.1 ± 0.3, and we model the lens with a pseudo-isothermal elliptical mass distribution. A high external shear, and a discrepancy between the Einstein radius and the weak lensing velocity dispersion requires that the BGG must be offset from J0454's dark halo centre by at least 90-130 kpc. The X-ray halo is offset by 24 ± 16 kpc from the BGG, shows no signs of a cooling flow and can be fit by a single β-model. With LX = (1.4 ± 0.2) × 1043 erg s-1 J0454 falls onto standard cluster scaling relations, but appears cooler (T = 1.1 ± 0.1 keV) than expected (T ~ 2.0 keV). Taken all together, these data indicate that J0454 consists of two systems, a sparse cluster and an infalling fossil group, where the latter seeds the brightest cluster galaxy. An alternative to the sparse cluster could be a filament projected along the line of sight mimicking a cluster, with galaxies streaming towards the fossil group. This work is based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan; based on observations obtained with MegaPrime/MegaCam, a joint project of CFHT and CEA/DAPNIA, at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii; based on observations made with ESO Telescopes at the La Silla and Paranal Observatories, Chile (ESO DDT Programme 282.A-5066); based on observations made with the NASA/ESA Hubble Space Telescope (programme #9836) obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555; based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA; based on data obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation.

The effect of baryons in the cosmological lensing PDFs

NASA Astrophysics Data System (ADS)

Castro, Tiago; Quartin, Miguel; Giocoli, Carlo; Borgani, Stefano; Dolag, Klaus

2018-07-01

Observational cosmology is passing through a unique moment of grandeur with the amount of quality data growing fast. However, in order to better take advantage of this moment, data analysis tools have to keep up the pace. Understanding the effect of baryonic matter on the large-scale structure is one of the challenges to be faced in cosmology. In this work, we have thoroughly studied the effect of baryonic physics on different lensing statistics. Making use of the Magneticum Pathfinder suite of simulations, we show that the influence of luminous matter on the 1-point lensing statistics of point sources is significant, enhancing the probability of magnified objects with μ > 3 by a factor of 2 and the occurrence of multiple images by a factor of 5-500, depending on the source redshift and size. We also discuss the dependence of the lensing statistics on the angular resolution of sources. Our results and methodology were carefully tested to guarantee that our uncertainties are much smaller than the effects here presented.

The effects of iris-ciliary complex on the organ cultured rabbit ocular lens.

PubMed

Niyogi, T K; Emanuel, K; Parafina, J; Bagchi, M

1991-01-01

Freshly isolated rabbit lenses were cultured with and without attached iris-ciliary (IC)-complex for 24 hours in TC-199 medium. Subsequent morphological analysis revealed that the IC-complex cannot be maintained in serum-free medium. In addition an observed effect of the IC-complex on the co-cultured lenses could not be due only because of the cellular degeneration of the IC-complex. To test this possibility lenses with attached IC-complexes were incubated in 20% serum-containing TC-199 medium. The IC-complex cultured in 20% serum containing medium retained its normal morphology. However co-cultured lens cells displayed vacuoles and other signs of degeneration. The protein synthetic and Na+/K+ pump activities of these lenses were also significantly depressed. These data indicated that the observed effects of IC-complex on the lens were not due to its cellular degradation. Preliminary experiments showed that the IC-complex contains water soluble factor(s) which could effectively inhibit lens protein synthesis and Na+/K+ pump.

The effect of baryons in the cosmological lensing PDFs

NASA Astrophysics Data System (ADS)

Castro, Tiago; Quartin, Miguel; Giocoli, Carlo; Borgani, Stefano; Dolag, Klaus

2018-05-01

Observational cosmology is passing through a unique moment of grandeur with the amount of quality data growing fast. However, in order to better take advantage of this moment, data analysis tools have to keep up the pace. Understanding the effect of baryonic matter on the large-scale structure is one of the challenges to be faced in cosmology. In this work, we have thoroughly studied the effect of baryonic physics on different lensing statistics. Making use of the Magneticum Pathfinder suite of simulations we show that the influence of luminous matter on the 1-point lensing statistics of point sources is significant, enhancing the probability of magnified objects with μ > 3 by a factor of 2 and the occurrence of multiple-images by a factor 5 - 500 depending on the source redshift and size. We also discuss the dependence of the lensing statistics on the angular resolution of sources. Our results and methodology were carefully tested in order to guarantee that our uncertainties are much smaller than the effects here presented.

Soft Contact Lens Wear at Altitude: Effects of Hypoxia

DTIC Science & Technology

1988-01-01

conjunctiva (2). If the edema is severe, breakdown of some and aircraft with cabin pressures equivalent to lower altitudes, of the epithelial cells from...debris, conjunctival injection, and corneal epithelial of hydrogel lenses. International Contact Lens Clinic. 1983. staining, showed heightened...cornea may be severe enough to affect vision stnae accompanying the wearing of hydrogel lenses. Am. J. and preclude wearing soft contact lenses during

Gravitational lenses and large scale structure

NASA Technical Reports Server (NTRS)

Turner, Edwin L.

1987-01-01

Four possible statistical tests of the large scale distribution of cosmic material are described. Each is based on gravitational lensing effects. The current observational status of these tests is also summarized.

Design, fabrication and evaluation of chalcogenide glass Luneburg lenses for LiNbO3 integrated optical devices

NASA Technical Reports Server (NTRS)

Wood, V. E.; Busch, J. R.; Verber, C. M.

1982-01-01

Optical waveguide Luneburg lenses of arsenic trisulfide glass are described. The lenses are formed by thermal evaporation of As2S3 through suitably placed masks onto the surface of LiNbO3:Ti indiffused waveguides. The lenses are designed for input apertures up to 1 cm and for speeds of f/5 or better. They are designed to focus the TM sub 0 guided mode of a beam of wavelength, external to the guide, of 633 nm. The refractive index of the As2S3 films and the changes induced in the refractive index by exposure to short wavelength light were measured. Some correlation between film thickness and optical properties was noted. The short wavelength photosensitivity was used to shorten the lens focal length from the as deposited value. Lenses of rectangular shape, as viewed from above the guide, as well as conventional circular Luneburg lenses, were made. Measurements made on the lenses include thickness profile, general optical quality, focal length, quality of focal spot, and effect of ultraviolet irradiation on optical properties.

Variable focus photographic lens without mechanical movements

NASA Astrophysics Data System (ADS)

Chen, Jiabi; Peng, Runling; Zhuang, Songlin

2007-09-01

A novel design of a zoom lens system without motorized movements is proposed. The lens system consists of a fixed lens and two double-liquid variable-focus lenses. The liquid lenses, made out of two immiscible liquids, are based on the principle of electrowetting: an effect controlling the wetting properties of a liquid on a solid by modifying the applied voltage at the solid-liquid interface. The structure and principle of the lens system are introduced in this paper. And detailed calculations and simulation examples are presented to predict how two liquid lenses are related to meet the basic requirements of zoom lenses.

Substructure based modeling of nickel single crystals cycled at low plastic strain amplitudes

NASA Astrophysics Data System (ADS)

Zhou, Dong

In this dissertation a meso-scale, substructure-based, composite single crystal model is fully developed from the simple uniaxial model to the 3-D finite element method (FEM) model with explicit substructures and further with substructure evolution parameters, to simulate the completely reversed, strain controlled, low plastic strain amplitude cyclic deformation of nickel single crystals. Rate-dependent viscoplasticity and Armstrong-Frederick type kinematic hardening rules are applied to substructures on slip systems in the model to describe the kinematic hardening behavior of crystals. Three explicit substructure components are assumed in the composite single crystal model, namely "loop patches" and "channels" which are aligned in parallel in a "vein matrix," and persistent slip bands (PSBs) connected in series with the vein matrix. A magnetic domain rotation model is presented to describe the reverse magnetostriction of single crystal nickel. Kinematic hardening parameters are obtained by fitting responses to experimental data in the uniaxial model, and the validity of uniaxial assumption is verified in the 3-D FEM model with explicit substructures. With information gathered from experiments, all control parameters in the model including hardening parameters, volume fraction of loop patches and PSBs, and variation of Young's modulus etc. are correlated to cumulative plastic strain and/or plastic strain amplitude; and the whole cyclic deformation history of single crystal nickel at low plastic strain amplitudes is simulated in the uniaxial model. Then these parameters are implanted in the 3-D FEM model to simulate the formation of PSB bands. A resolved shear stress criterion is set to trigger the formation of PSBs, and stress perturbation in the specimen is obtained by several elements assigned with PSB material properties a priori. Displacement increment, plastic strain amplitude control and overall stress-strain monitor and output are carried out in the user subroutine DISP and URDFIL of ABAQUS, respectively, while constitutive formulations of the FEM model are coded and implemented in UMAT. The results of the simulations are compared to experiments. This model verified the validity of Winter's two-phase model and Taylor's uniform stress assumption, explored substructure evolution and "intrinsic" behavior in substructures and successfully simulated the process of PSB band formation and propagation.

Conjunctival epithelial flap in continuous contact lens wear.

PubMed

Graham, Andrew D; Truong, Tan N; Lin, Meng C

2009-04-01

Composed of sheets of cells detached from the underlying conjunctiva, conjunctival epithelial flap (CEF) is a recently reported phenomenon associated with contact lens wear with potential consequences for ocular health. Although CEF is generally asymptomatic, it is not known to what extent it might increase the longer-term risk of discomfort, inflammatory response, or infection. In this study, we use survival analysis methods to obtain unbiased estimates of the probability of developing CEF, the mean survival time free of CEF, and the effects of age, gender, ethnicity, and contact lens type. Two hundred four subjects were recruited for a continuous wear (CW) study of silicone hydrogel (SiH) and gas permeable (GP) contact lenses. Subjects were examined by optometrists throughout contact lens adaptation and CW periods. Statistical methods included the Kaplan-Meier nonparametric estimator of the survival function and the Cox proportional hazards model for estimating the relative effects of covariates. Of the 204 subjects, 72 (35%) developed CEF. In 64% of cases, CEFs were observed bilaterally. The majority of cases (90.3%) presented with CEF in the superior conjunctiva. Mean survival time free of CEF was longer for GP lenses (94.3 days) than for SiH lenses (76.5 days), and the probability of developing CEF was significantly greater for SiH lenses (p = 0.002). Although there was some evidence that women and non-Asians remain free of CEF longer, the effects of age, gender, and ethnicity were not statistically significant. There was a significantly increased risk of CEF in subjects wearing SiH lenses, compared with GP lenses. Subjects wearing SiH lenses remained free of CEF for a shorter time on average. Further study is needed to determine whether the increased incidence of CEF in CW with SiH lenses poses an increased risk of adverse ocular response or infection.

Extended Ciprofloxacin Release Using Vitamin E Diffusion Barrier From Commercial Silicone-Based Soft Contact Lenses.

PubMed

Shayani Rad, Maryam; Mohajeri, Seyed Ahmad

2017-03-01

Ciprofloxacin (Cipro) is an antibiotic, widely used in form of ophthalmic drops (0.3%) for the treatment of eye infections. In this study, vitamin E was used as a hydrophobic barrier to improve and prolong the amount and time of Cipro release from silicone-based soft contact lenses. Three different commercial contact lenses (Air Optix, Biofinity, and Acuvue Oasys) were soaked in vitamin E solutions (0.1 and 0.2 g/mL). The effect of vitamin E on Cipro loading amount and drug releasing profile was evaluated in artificial tear. Swelling properties and diameter changes of the lenses were also investigated in aqueous media in presence and absence of vitamin E. The data indicated that vitamin E, as a hydrophobic barrier, significantly decreased the water content of silicone-based soft contact lenses. After vitamin E loading, a 5% to 18% increase was observed in lens diameter in the hydrated state, whereas the lens diameter increased by 11% to 23% in the dry state. In all commercial lenses, vitamin E loading in a 0.2-g/mL solution caused a 27.94% to 37.08% increase in Cipro binding. The results indicated that applying vitamin E loading solutions, with 0.1 and 0.2 g/mL concentrations, could effectively enhance Cipro release time from 2 hr (in a pure non-vitamin E-loaded lens) to 14 to 17 and 30 to 33 days, respectively. These values showed an increase by a factor of 168 to 204 and 360 to 396 in Cipro release time after using vitamin E loading solutions with 0.1 and 0.2 g/mL concentrations, respectively, compared with pure non-vitamin E-loaded soft contact lenses. This study indicated that vitamin E acts as an effective hydrophobic barrier, in increasing the Cipro loading capacity of silicone-based contact lenses and prolonging the drug release into the artificial tear.

Shadows and strong gravitational lensing: a brief review

NASA Astrophysics Data System (ADS)

Cunha, Pedro V. P.; Herdeiro, Carlos A. R.

2018-04-01

For ultra compact objects, light rings and fundamental photon orbits (FPOs) play a pivotal role in the theoretical analysis of strong gravitational lensing effects, and of BH shadows in particular. In this short review, specific models are considered to illustrate how FPOs can be useful in order to understand some non-trivial gravitational lensing effects. This paper aims at briefly overviewing the theoretical foundations of these effects, touching also some of the related phenomenology, both in general relativity and alternative theories of gravity, hopefully providing some intuition and new insights for the underlying physics, which might be critical when testing the Kerr black hole hypothesis.

Controlled release of betamethasone from vitamin E-loaded silicone-based soft contact lenses.

PubMed

Rad, Maryam Shayani; Sajadi Tabassi, Sayyed Abolghasem; Moghadam, Maryam Hassanpour; Mohajeri, Seyed Ahmad

2016-11-01

Betamethasone (BMZ) is an effective drug which is commonly used as an eye drop for the management of ophthalmic inflammations. Due to low ocular bioavailability, it is necessary to prepare and optimize an ocular drug delivery system for BMZ. In this study we tried to use vitamin E diffusion barrier for sustaining BMZ release. Three commercial contact lenses were soaked in vitamin E solutions and swelling percentage, diameter, transmittance, binding capacity and release amount and time were evaluated in comparison with non-vitamin E-loaded pure lenses. The results showed that vitamin E significantly decreased water content of contact lenses whereas, increased the lens diameter in both dry and wet states. It effectively blocked UV radiation which is harmful for the eye surface while had no significant effect on visible transmittance. BMZ loading capacity enhanced and release rate remarkably decreased after using vitamin E as a hydrophobic diffusion barrier. This study revealed that vitamin E can be applied as a hydrophobic diffusion barrier for controlling and sustaining BMZ release from silicone-based soft contact lenses into the lachrymal fluid. It can also protect eye tissues as an antioxidant by blocking the UV radiation.

Gravitational Lensing in Astronomy.

PubMed

Wambsganss, Joachim

1998-01-01

Deflection of light by gravity was predicted by General Relativity and observationally confirmed in 1919. In the following decades, various aspects of the gravitational lens effect were explored theoretically. Among them were: the possibility of multiple or ring-like images of background sources, the use of lensing as a gravitational telescope on very faint and distant objects, and the possibility of determining Hubble's constant with lensing. It is only relatively recently, (after the discovery of the first doubly imaged quasar in 1979), that gravitational lensing has became an observational science. Today lensing is a booming part of astrophysics. In addition to multiply-imaged quasars, a number of other aspects of lensing have been discovered: For example, giant luminous arcs, quasar microlensing, Einstein rings, galactic microlensing events, arclets, and weak gravitational lensing. At present, literally hundreds of individual gravitational lens phenomena are known. Although still in its childhood, lensing has established itself as a very useful astrophysical tool with some remarkable successes. It has contributed significant new results in areas as different as the cosmological distance scale, the large scale matter distribution in the universe, mass and mass distribution of galaxy clusters, the physics of quasars, dark matter in galaxy halos, and galaxy structure. Looking at these successes in the recent past we predict an even more luminous future for gravitational lensing. Supplementary material is available for this article at 10.12942/lrr-1998-12.

Fiber-reinforced composite substructure: load-bearing capacity of an onlay restoration and flexural properties of the material.

PubMed

Garoushi, Sufyan K; Lassila, Lippo V J; Tezvergil, Arzu; Vallittu, Pekka K

2006-09-01

The aim of this study was to determine the static load-bearing capacity of composite resin onlay restorations made of particulate filler composite (PFC) with two different types of fiber-reinforced composite (FRC) substructures. In addition, flexural properties of the material combination and the effect of polymerization devices were tested. Specimens were prepared to simulate an onlay restoration, which consisted of 2 to 3 mm of FRC layer as a substructure (short random and continuous bidirectional fiber orientation) and a 1 mm surface layer of PFC. Control specimens were prepared from plain PFC. In Group A the specimens were incrementally polymerized only with a hand-light curing unit for 40 s, while in Group B the specimens were post-cured in a light-curing oven for 15 min before they were statically loaded with a steel ball. Bar-shaped test specimens were prepared to measure the flexural properties of material combination using a three-point bending test (ISO 10477). Analysis of variance (ANOVA) revealed all specimens with a FRC substructure have higher values of static load-bearing capacity and flexural properties than those obtained with plain PFC (p<0.001). The load-bearing capacity of all the specimens decreased after post-curing and water storage. Restorations made from a material combination of FRC and PFC showed better mechanical properties than those obtained with plain PFC.

Understanding the large-scale structure from the cosmic microwave background: shear calibration with CMB lensing; gas physics from the kinematic Sunyaev-Zel'dovich effect

NASA Astrophysics Data System (ADS)

Schaan, Emmanuel

2017-01-01

I will present two promising ways in which the cosmic microwave background (CMB) sheds light on critical uncertain physics and systematics of the large-scale structure. Shear calibration with CMB lensing: Realizing the full potential of upcoming weak lensing surveys requires an exquisite understanding of the errors in galaxy shape estimation. In particular, such errors lead to a multiplicative bias in the shear, degenerate with the matter density parameter and the amplitude of fluctuations. Its redshift-evolution can hide the true evolution of the growth of structure, which probes dark energy and possible modifications to general relativity. I will show that CMB lensing from a stage 4 experiment (CMB S4) can self-calibrate the shear for an LSST-like optical lensing survey. This holds in the presence of photo-z errors and intrinsic alignment. Evidence for the kinematic Sunyaev-Zel'dovich (kSZ) effect; cluster energetics: Through the kSZ effect, the baryon momentum field is imprinted on the CMB. I will report significant evidence for the kSZ effect from ACTPol and peculiar velocities reconstructed from BOSS. I will present the prospects for constraining cluster gas profiles and energetics from the kSZ effect with SPT-3G, AdvACT and CMB S4. This will provide constraints on galaxy formation and feedback models.

CMB ISW-lensing bispectrum from cosmic strings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamauchi, Daisuke; Sendouda, Yuuiti; Takahashi, Keitaro, E-mail: yamauchi@resceu.s.u-tokyo.ac.jp, E-mail: sendouda@cc.hirosaki-u.ac.jp, E-mail: keitaro@sci.kumamoto-u.ac.jp

2014-02-01

We study the effect of weak lensing by cosmic (super-)strings on the higher-order statistics of the cosmic microwave background (CMB). A cosmic string segment is expected to cause weak lensing as well as an integrated Sachs-Wolfe (ISW) effect, the so-called Gott-Kaiser-Stebbins (GKS) effect, to the CMB temperature fluctuation, which are thus naturally cross-correlated. We point out that, in the presence of such a correlation, yet another kind of the post-recombination CMB temperature bispectra, the ISW-lensing bispectra, will arise in the form of products of the auto- and cross-power spectra. We first present an analytic method to calculate the autocorrelation ofmore » the temperature fluctuations induced by the strings, and the cross-correlation between the temperature fluctuation and the lensing potential both due to the string network. In our formulation, the evolution of the string network is assumed to be characterized by the simple analytic model, the velocity-dependent one scale model, and the intercommutation probability is properly incorporated in order to characterize the possible superstringy nature. Furthermore, the obtained power spectra are dominated by the Poisson-distributed string segments, whose correlations are assumed to satisfy the simple relations. We then estimate the signal-to-noise ratios of the string-induced ISW-lensing bispectra and discuss the detectability of such CMB signals from the cosmic string network. It is found that in the case of the smaller string tension, Gμ << 10{sup -7}, the ISW-lensing bispectrum induced by a cosmic string network can constrain the string-model parameters even more tightly than the purely GKS-induced bispectrum in the ongoing and future CMB observations on small scales.« less

CMB ISW-lensing bispectrum from cosmic strings

NASA Astrophysics Data System (ADS)

Yamauchi, Daisuke; Sendouda, Yuuiti; Takahashi, Keitaro

2014-02-01

We study the effect of weak lensing by cosmic (super-)strings on the higher-order statistics of the cosmic microwave background (CMB). A cosmic string segment is expected to cause weak lensing as well as an integrated Sachs-Wolfe (ISW) effect, the so-called Gott-Kaiser-Stebbins (GKS) effect, to the CMB temperature fluctuation, which are thus naturally cross-correlated. We point out that, in the presence of such a correlation, yet another kind of the post-recombination CMB temperature bispectra, the ISW-lensing bispectra, will arise in the form of products of the auto- and cross-power spectra. We first present an analytic method to calculate the autocorrelation of the temperature fluctuations induced by the strings, and the cross-correlation between the temperature fluctuation and the lensing potential both due to the string network. In our formulation, the evolution of the string network is assumed to be characterized by the simple analytic model, the velocity-dependent one scale model, and the intercommutation probability is properly incorporated in order to characterize the possible superstringy nature. Furthermore, the obtained power spectra are dominated by the Poisson-distributed string segments, whose correlations are assumed to satisfy the simple relations. We then estimate the signal-to-noise ratios of the string-induced ISW-lensing bispectra and discuss the detectability of such CMB signals from the cosmic string network. It is found that in the case of the smaller string tension, Gμ << 10-7, the ISW-lensing bispectrum induced by a cosmic string network can constrain the string-model parameters even more tightly than the purely GKS-induced bispectrum in the ongoing and future CMB observations on small scales.

A NASTRAN model of a large flexible swing-wing bomber. Volume 3: NASTRAN model development-wing structure

NASA Technical Reports Server (NTRS)

Mock, W. D.; Latham, R. A.

1982-01-01

The NASTRAN model plan for the wing structure was expanded in detail to generate the NASTRAN model for this substructure. The grid point coordinates were coded for each element. The material properties and sizing data for each element were specified. The wing substructure model was thoroughly checked out for continuity, connectivity, and constraints. This substructure was processed for structural influence coefficients (SIC) point loadings and the deflections were compared to those computed for the aircraft detail model. Finally, a demonstration and validation processing of this substructure was accomplished using the NASTRAN finite element program. The bulk data deck, stiffness matrices, and SIC output data were delivered.

A NASTRAN model of a large flexible swing-wing bomber. Volume 2: NASTRAN model development-horizontal stabilzer, vertical stabilizer and nacelle structures

NASA Technical Reports Server (NTRS)

Mock, W. D.; Latham, R. A.; Tisher, E. D.

1982-01-01

The NASTRAN model plans for the horizontal stabilizer, vertical stabilizer, and nacelle structure were expanded in detail to generate the NASTRAN model for each of these substructures. The grid point coordinates were coded for each element. The material properties and sizing data for each element were specified. Each substructure model was thoroughly checked out for continuity, connectivity, and constraints. These substructures were processed for structural influence coefficients (SIC) point loadings and the deflections were compared to those computed for the aircraft detail models. Finally, a demonstration and validation processing of these substructures was accomplished using the NASTRAN finite element program installed at NASA/DFRC facility.

A NASTRAN model of a large flexible swing-wing bomber. Volume 4: NASTRAN model development-fuselage structure

NASA Technical Reports Server (NTRS)

Mock, W. D.; Latham, R. A.

1982-01-01

The NASTRAN model plan for the fuselage structure was expanded in detail to generate the NASTRAN model for this substructure. The grid point coordinates were coded for each element. The material properties and sizing data for each element were specified. The fuselage substructure model was thoroughly checked out for continuity, connectivity, and constraints. This substructure was processed for structural influence coefficients (SIC) point loadings and the deflections were compared to those computed for the aircraft detail model. Finally, a demonstration and validation processing of this substructure was accomplished using the NASTRAN finite element program. The bulk data deck, stiffness matrices, and SIC output data were delivered.

Structural optimization by generalized, multilevel decomposition

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, J.; James, B. B.; Riley, M. F.

1985-01-01

The developments toward a general multilevel optimization capability and results for a three-level structural optimization are described. The method partitions a structure into a number of substructuring levels where each substructure corresponds to a subsystem in the general case of an engineering system. The method is illustrated by a portal framework that decomposes into individual beams. Each beam is a box that can be further decomposed into stiffened plates. Substructuring for this example spans three different levels: (1) the bottom level of finite elements representing the plates; (2) an intermediate level of beams treated as substructures; and (3) the top level for the assembled structure. The three-level case is now considered to be qualitatively complete.

Glutathione Preservation during Storage of Rat Lenses in Optisol-GS and Castor Oil

PubMed Central

Holm, Thomas; Brøgger-Jensen, Martin Rocho; Johnson, Leif; Kessel, Line

2013-01-01

Background Glutathione concentration in the lens decreases in aging and cataractous lenses, providing a marker for tissue condition. Experimental procedures requiring unfrozen lenses from donor banks rely on transportation in storage medium, affecting lens homeostasis and alterations in glutathione levels. The aim of the study was to examine the effects of Optisol-GS and castor oil on lens condition, determined from their ability to maintain glutathione concentrations. Methodology/Principal Findings Rat lenses were stored in the two types of storage media at varying time intervals up to 3 days. Glutathione concentration was afterwards determined in an enzymatic detection assay, specific for both reduced and oxidized forms. Lenses removed immediately after death exhibited a glutathione concentration of 4.70±0.29 mM. In vitro stored lenses in Optisol-GS lost glutathione quickly, ending with a concentration of 0.60±0.34 mM after 3 days while castor oil stored lenses exhibited a slower decline and ended at 3 times the concentration. A group of lenses were additionally stored under post mortem conditions within the host for 6 hours before its removal. Total glutathione after 6 hours was similar to that of lenses removed immediately after death, but with altered GSH and GSSG concentrations. Subsequent storage of these lenses in media showed changes similar to those in the first series of experiments, albeit to a lesser degree. Conclusions/Significance It was determined that storage in Optisol-GS resulted in a higher loss of glutathione than lenses stored in castor oil. Storage for more than 12 hours reduced glutathione to half its original concentration, and was considered unusable after 24 hours. PMID:24260265

Constraints on Cosmological Parameters from the Angular Power Spectrum of a Combined 2500 deg2 SPT-SZ and Planck Gravitational Lensing Map

NASA Astrophysics Data System (ADS)

Simard, G.; Omori, Y.; Aylor, K.; Baxter, E. J.; Benson, B. A.; Bleem, L. E.; Carlstrom, J. E.; Chang, C. L.; Cho, H.-M.; Chown, R.; Crawford, T. M.; Crites, A. T.; de Haan, T.; Dobbs, M. A.; Everett, W. B.; George, E. M.; Halverson, N. W.; Harrington, N. L.; Henning, J. W.; Holder, G. P.; Hou, Z.; Holzapfel, W. L.; Hrubes, J. D.; Knox, L.; Lee, A. T.; Leitch, E. M.; Luong-Van, D.; Manzotti, A.; McMahon, J. J.; Meyer, S. S.; Mocanu, L. M.; Mohr, J. J.; Natoli, T.; Padin, S.; Pryke, C.; Reichardt, C. L.; Ruhl, J. E.; Sayre, J. T.; Schaffer, K. K.; Shirokoff, E.; Staniszewski, Z.; Stark, A. A.; Story, K. T.; Vanderlinde, K.; Vieira, J. D.; Williamson, R.; Wu, W. L. K.

2018-06-01

We report constraints on cosmological parameters from the angular power spectrum of a cosmic microwave background (CMB) gravitational lensing potential map created using temperature data from 2500 deg2 of South Pole Telescope (SPT) data supplemented with data from Planck in the same sky region, with the statistical power in the combined map primarily from the SPT data. We fit the lensing power spectrum to a model including cold dark matter and a cosmological constant ({{Λ }}{CDM}), and to models with single-parameter extensions to {{Λ }}{CDM}. We find constraints that are comparable to and consistent with those found using the full-sky Planck CMB lensing data, e.g., {σ }8{{{Ω }}}{{m}}0.25 = 0.598 ± 0.024 from the lensing data alone with weak priors placed on other parameters. Combining with primary CMB data, we explore single-parameter extensions to {{Λ }}{CDM}. We find {{{Ω }}}k =-{0.012}-0.023+0.021 or {M}ν < 0.70 eV at 95% confidence, in good agreement with results including the lensing potential as measured by Planck. We include two parameters that scale the effect of lensing on the CMB: {A}L, which scales the lensing power spectrum in both the lens reconstruction power and in the smearing of the acoustic peaks, and {A}φ φ , which scales only the amplitude of the lensing reconstruction power spectrum. We find {A}φ φ × {A}L = 1.01 ± 0.08 for the lensing map made from combined SPT and Planck data, indicating that the amount of lensing is in excellent agreement with expectations from the observed CMB angular power spectrum when not including the information from smearing of the acoustic peaks.

[What is the role of contact lenses within the scope of electronystagmography?].

PubMed

Schmäl, F; Stoll, W

1997-10-01

During electronystagmography it is necessary to correct detective vision for calibration, smooth pursuit, and saccadic eye movements. Therefore more and more people use contact lenses instead of normal glasses. Given the lack of detailed information about this phenomenon, in the current literature we decided to investigate the influence of soft contact lenses on electronystagmography. The aim of this study was to find out differences in the results of electronystagmography between using glasses or contact lenses. Our investigation involved 20 vestibular healthy human subjects with myopia. In the first part of the examination they used their contact lenses and in the second part they were wearing normal glasses. After measuring the calibration potential we wanted to see if contact lenses would increase the rate of artifacts in the electronystagmogram. Then we attempted to determine whether contact lenses would an influence on the registration of the optokinetic nystagmus. Induced saccadic eye movements were recorded and analysed. Contact lenses had a negative influence neither on the calibration potential nor on the rate of artifacts. The latency of the saccadic eye movements also showed no differences between both parts of this investigation. Only the velocity of the saccades and the gain value during the optokinetic test were reduced when glasses were used. Contact lenses may stimulate the secretory function of the lacrimal gland and thus decrease friction forces. It is also possible that the reduced image size produced or the reduction-effect of minus by glasses in near sighted persons negatively influences eyeball velocity. In summary, our study demonstrates that contact lenses do not have a negative influence on electronystagmography. Therefore electronystagmographic studies of patients with contact lenses are permissible for purposes of documenting a medical opinion.

Difference Imaging of Lensed Quasar Candidates in the Sloan Digital Sky Survey Supernova Survey Region

NASA Astrophysics Data System (ADS)

Lacki, Brian C.; Kochanek, Christopher S.; Stanek, Krzysztof Z.; Inada, Naohisa; Oguri, Masamune

2009-06-01

Difference imaging provides a new way to discover gravitationally lensed quasars because few nonlensed sources will show spatially extended, time variable flux. We test the method on the fields of lens candidates in the Sloan Digital Sky Survey (SDSS) Supernova Survey region from the SDSS Quasar Lens Search (SQLS) and one serendipitously discovered lensed quasar. Starting from 20,536 sources, including 49 SDSS quasars, 32 candidate lenses/lensed images, and one known lensed quasar, we find that 174 sources including 35 SDSS quasars, 16 candidate lenses/lensed images, and the known lensed quasar are nonperiodic variable sources. We can measure the spatial structure of the variable flux for 119 of these variable sources and identify only eight as candidate extended variables, including the known lensed quasar. Only the known lensed quasar appears as a close pair of sources on the difference images. Inspection of the remaining seven suggests they are false positives, and only two were spectroscopically identified quasars. One of the lens candidates from the SQLS survives our cuts, but only as a single image instead of a pair. This indicates a false positive rate of order ~1/4000 for the method, or given our effective survey area of order 0.82 deg2, ~5 per deg2 in the SDSS Supernova Survey. The fraction of quasars not found to be variable and the false positive rate would both fall if we had analyzed the full, later data releases for the SDSS fields. While application of the method to the SDSS is limited by the resolution, depth, and sampling of the survey, several future surveys such as Pan-STARRS, LSST, and SNAP will significantly improve on these limitations.

Research and analysis on new test lenses for calibration of focimeters used for measuring contact lenses

NASA Astrophysics Data System (ADS)

Zhang, Jiyan; Wang, Liru; Ma, Zhenya

2006-11-01

A focimeter is one of the basic ophthalmic instruments used in every optometric practice, and verification of the accuracy and calibration of the instrument are of the utmost importance. For many years the International Standardization for Organization requires that calibrations for all kinds of focimeters shall be accomplished by using test lenses described in ISO 9342:1996. These test lenses must be of high quality and of nominal back vertex power that is known with high accuracy. With the development of science and technology, ISO 9342 was revised in 2005. A new part ISO 9342-2 had been drafted for test lenses used to calibrate focimeters with contact lens measurement, and the original ISO 9342 was turned into the current ISO 9342-1, which could only be used to calibrate fociemters with spectacle lens measurement. As one of the standard drafters, the background for the newly published ISO 9342-2 is introduced in this study, and comparison between test lenses of ISO 9342-1 and ISO 9342-2 is made. Further, the influence of tolerance and uncertainty in design and production of standard test lenses of ISO 9342-2 is analyzed. The paraxial approximation is used to relate the lens parameters with back vertex power and to calculate the uncertainty budget. Moreover, one set of test lenses conforming to ISO 9342-2 is manufactured and experiments are done with it. Results show that test lenses described in ISO 9342-2 can correct the measurement errors of focimeters used for measuring contact lenses well, especially for spherical aberration, and the correction is more effective for spherical contact lenses with high back vertex power.

Thermoelectric materials ternary penta telluride and selenide compounds

DOEpatents

Sharp, Jeffrey W.

2001-01-01

Ternary tellurium compounds and ternary selenium compounds may be used in fabricating thermoelectric devices with a thermoelectric figure of merit (ZT) of 1.5 or greater. Examples of such compounds include Tl.sub.2 SnTe.sub.5, Tl.sub.2 GeTe.sub.5, K.sub.2 SnTe.sub.5 and Rb.sub.2 SnTe.sub.5. These compounds have similar types of crystal lattice structures which include a first substructure with a (Sn, Ge) Te.sub.5 composition and a second substructure with chains of selected cation atoms. The second substructure includes selected cation atoms which interact with selected anion atoms to maintain a desired separation between the chains of the first substructure. The cation atoms which maintain the desired separation between the chains occupy relatively large electropositive sites in the resulting crystal lattice structure which results in a relatively low value for the lattice component of thermal conductivity (.kappa..sub.g). The first substructure of anion chains indicates significant anisotropy in the thermoelectric characteristics of the resulting semiconductor materials.

Thermoelectric materials: ternary penta telluride and selenide compounds

DOEpatents

Sharp, Jeffrey W.

2002-06-04

Ternary tellurium compounds and ternary selenium compounds may be used in fabricating thermoelectric devices with a thermoelectric figure of merit (ZT) of 1.5 or greater. Examples of such compounds include Tl.sub.2 SnTe.sub.5, Tl.sub.2 GeTe.sub.5, K.sub.2 SnTe.sub.5 and Rb.sub.2 SnTe.sub.5. These compounds have similar types of crystal lattice structures which include a first substructure with a (Sn, Ge) Te.sub.5 composition and a second substructure with chains of selected cation atoms. The second substructure includes selected cation atoms which interact with selected anion atoms to maintain a desired separation between the chains of the first substructure. The cation atoms which maintain the desired separation between the chains occupy relatively large electropositive sites in the resulting crystal lattice structure which results in a relatively low value for the lattice component of thermal conductivity (.kappa..sub.g). The first substructure of anion chains indicates significant anisotropy in the thermoelectric characteristics of the resulting semiconductor materials.

Allele frequency data for 15 autosomal STR loci in eight Indonesian subpopulations.

PubMed

Venables, Samantha J; Daniel, Runa; Sarre, Stephen D; Soedarsono, Nurtami; Sudoyo, Herawati; Suryadi, Helena; van Oorschot, Roland A H; Walsh, Simon J; Widodo, Putut T; McNevin, Dennis

2016-01-01

Evolutionary and cultural history can affect the genetic characteristics of a population and influences the frequency of different variants at a particular genetic marker (allele frequency). These characteristics directly influence the strength of forensic DNA evidence and make the availability of suitable allele frequency information for every discrete country or jurisdiction highly relevant. Population sub-structure within Indonesia has not been well characterised but should be expected given the complex geographical, linguistic and cultural architecture of the Indonesian population. Here we use forensic short tandem repeat (STR) markers to identify a number of distinct genetic subpopulations within Indonesia and calculate appropriate population sub-structure correction factors. This data represents the most comprehensive investigation of population sub-structure within Indonesia to date using these markers. The results demonstrate that significant sub-structure is present within the Indonesian population and must be accounted for using island specific allele frequencies and corresponding sub-structure correction factors in the calculation of forensic DNA match statistics. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Effect of Unifocal versus Multifocal Lenses on Cervical Spine Posture in Patients with Presbyopia.

PubMed

Abbas, Rami L; Houri, Mohamad T; Rayyan, Mohammad M; Hamada, Hamada Ahmad; Saab, Ibtissam M

2018-04-04

There are many environmental considerations which may or may not lead to the development of faulty cervical mechanics. The design of near vision lenses could contribute to the development of such cervical dysfunction and consequently neck pain. Decision making regarding proper type of lens prescription seems important for presbyopic individuals. To investigate the effect of unifocal and multifocal lenses on cervical posture. Thirty subjects (18 females and 12 males) participated in the study with an age range from 40 to 64 years. Each subject wore consequently both unifocal and multifocal lenses randomly while reading. Then lateral cervical spine X-ray films were taken for each subject during each lens wearing. X-ray films were analyzed with digital software (Autocad software, 2 D) to measure segmental angles of the cervical vertebrae (Occiput/C1, C1/C2, C2/C3, C3/C4, C4/C5, C5/C6, C6/C7, C3/C7, C0/C3, and occiput/C7). Higher significant extension angle in the segments C0/C7, C1/C2, C5/C6, C6/C7, and C3/C7 (p<0.05) during multifocal lenses wearing were observed in contrast with higher flexion angle between C3/C4 and C4/C5 (p<0.05) with unifocal lenses wear. Multifocal lens spectacles produces increased extension in the cervical vertebrae angles when compared with the use of unifocal lenses.

DEMNUni: ISW, Rees-Sciama, and weak-lensing in the presence of massive neutrinos

NASA Astrophysics Data System (ADS)

Carbone, Carmelita; Petkova, Margarita; Dolag, Klaus

2016-07-01

We present, for the first time in the literature, a full reconstruction of the total (linear and non-linear) ISW/Rees-Sciama effect in the presence of massive neutrinos, together with its cross-correlations with CMB-lensing and weak-lensing signals. The present analyses make use of all-sky maps extracted via ray-tracing across the gravitational potential distribution provided by the ``Dark Energy and Massive Neutrino Universe'' (DEMNUni) project, a set of large-volume, high-resolution cosmological N-body simulations, where neutrinos are treated as separate collisionless particles. We correctly recover, at 1-2% accuracy, the linear predictions from CAMB. Concerning the CMB-lensing and weak-lensing signals, we also recover, with similar accuracy, the signal predicted by Boltzmann codes, once non-linear neutrino corrections to HALOFIT are accounted for. Interestingly, in the ISW/Rees-Sciama signal, and its cross correlation with lensing, we find an excess of power with respect to the massless case, due to free streaming neutrinos, roughly at the transition scale between the linear and non-linear regimes. The excess is ~ 5 - 10% at l ~ 100 for the ISW/Rees-Sciama auto power spectrum, depending on the total neutrino mass Mν, and becomes a factor of ~ 4 for Mν = 0.3 eV, at l ~ 600, for the ISW/Rees-Sciama cross power with CMB-lensing. This effect should be taken into account for the correct estimation of the CMB temperature bispectrum in the presence of massive neutrinos.

Serendipitous discovery of a strong-lensed galaxy in integral field spectroscopy from MUSE

NASA Astrophysics Data System (ADS)

Galbany, Lluís; Collett, Thomas E.; Méndez-Abreu, Jairo; Sánchez, Sebastián F.; Anderson, Joseph P.; Kuncarayakti, Hanindyo

2018-06-01

2MASX J04035024-0239275 is a bright red elliptical galaxy at redshift 0.0661 that presents two extended sources at 2″ to the north-east and 1″ to the south-west. The sizes and surface brightnesses of the two blue sources are consistent with a gravitationally-lensed background galaxy. In this paper we present MUSE observations of this galaxy from the All-weather MUse Supernova Integral-field Nearby Galaxies (AMUSING) survey, and report the discovery of a background lensed galaxy at redshift 0.1915, together with other 15 background galaxies at redshifts ranging from 0.09 to 0.9, that are not multiply imaged. We have extracted aperture spectra of the lens and all the sources and fit the stellar continuum with STARLIGHT to estimate their stellar and emission line properties. A trace of past merger and active nucleus activity is found in the lensing galaxy, while the background lensed galaxy is found to be star-forming. Modeling the lensing potential with a singular isothermal ellipsoid, we find an Einstein radius of 1."45±0."04, which corresponds to 1.9 kpc at the redshift of the lens and it is much smaller than its effective radius (reff ˜ 9″"). Comparing the Einstein mass and the STARLIGHT stellar mass within the same aperture yields a dark matter fraction of 18% ± 8 % within the Einstein radius. The advent of large surveys such as the Large Synoptic Survey Telescope (LSST) will discover a number of strong-lensed systems, and here we demonstrate how wide-field integral field spectroscopy offers an excellent approach to study them and to precisely model lensing effects.

Observational selection biases in time-delay strong lensing and their impact on cosmography

NASA Astrophysics Data System (ADS)

Collett, Thomas E.; Cunnington, Steven D.

2016-11-01

Inferring cosmological parameters from time-delay strong lenses requires a significant investment of telescope time; it is therefore tempting to focus on the systems with the brightest sources, the highest image multiplicities and the widest image separations. We investigate if this selection bias can influence the properties of the lenses studied and the cosmological parameters inferred. Using an ellipsoidal power-law deflector population, we build a sample of double- and quadruple-image systems. Assuming reasonable thresholds on image separation and flux, based on current lens monitoring campaigns, we find that the typical density profile slopes of monitorable lenses are significantly shallower than the input ensemble. From a sample of quads, we find that this selection function can introduce a 3.5 per cent bias on the inferred time-delay distances if the properties of the input ensemble are (incorrectly) used as priors on the lens model. This bias remains at the 2.4 per cent level when high-resolution imaging of the quasar host is used to precisely infer the properties of individual lenses. We also investigate if the lines of sight for monitorable strong lenses are biased. The expectation value for the line-of-sight convergence is increased by 0.009 (0.004) for quads (doubles) implying a 0.9 per cent (0.4 per cent) bias on H0. We therefore conclude that whilst the properties of typical quasar lenses and their lines of sight do deviate from the global population, the total magnitude of this effect is likely to be a subdominant effect for current analyses, but has the potential to be a major systematic for samples of ˜25 or more lenses.

Cross-correlation of gravitational lensing from DES Science Verification data with SPT and Planck lensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirk, D.; Omori, Y.; Benoit-Lévy, A.

We measure the cross-correlation between weak lensing of galaxy images and of the cosmic microwave background (CMB). The effects of gravitational lensing on different sources will be correlated if the lensing is caused by the same mass fluctuations. We use galaxy shape measurements from 139 deg(2) of the Dark Energy Survey (DES) Science Verification data and overlapping CMB lensing from the South Pole Telescope (SPT) and Planck. The DES source galaxies have a median redshift of z(med) similar to 0.7, while the CMB lensing kernel is broad and peaks at z similar to 2. The resulting cross-correlation is maximally sensitivemore » to mass fluctuations at z similar to 0.44. Assuming the Planck 2015 best-fitting cosmology, the amplitude of the DESxSPT cross-power is found to be A(SPT) = 0.88 +/- 0.30 and that from DESxPlanck to be A(Planck) = 0.86 +/- 0.39, where A = 1 corresponds to the theoretical prediction. These are consistent with the expected signal and correspond to significances of 2.9 sigma and 2.2 sigma, respectively. We demonstrate that our results are robust to a number of important systematic effects including the shear measurement method, estimator choice, photo-z uncertainty and CMB lensing systematics. We calculate a value of A = 1.08 +/- 0.36 for DESxSPT when we correct the observations with a simple intrinsic alignment model. With three measurements of this cross-correlation now existing in the literature, there is not yet reliable evidence for any deviation from the expected LCDM level of cross-correlation. We provide forecasts for the expected signal-to-noise ratio of the combination of the five-year DES survey and SPT-3G.« less

Cross-correlation of gravitational lensing from DES Science Verification data with SPT and Planck lensing

NASA Astrophysics Data System (ADS)

Kirk, D.; Omori, Y.; Benoit-Lévy, A.; Cawthon, R.; Chang, C.; Larsen, P.; Amara, A.; Bacon, D.; Crawford, T. M.; Dodelson, S.; Fosalba, P.; Giannantonio, T.; Holder, G.; Jain, B.; Kacprzak, T.; Lahav, O.; MacCrann, N.; Nicola, A.; Refregier, A.; Sheldon, E.; Story, K. T.; Troxel, M. A.; Vieira, J. D.; Vikram, V.; Zuntz, J.; Abbott, T. M. C.; Abdalla, F. B.; Becker, M. R.; Benson, B. A.; Bernstein, G. M.; Bernstein, R. A.; Bleem, L. E.; Bonnett, C.; Bridle, S. L.; Brooks, D.; Buckley-Geer, E.; Burke, D. L.; Capozzi, D.; Carlstrom, J. E.; Rosell, A. Carnero; Kind, M. Carrasco; Carretero, J.; Crocce, M.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Eifler, T. F.; Evrard, A. E.; Flaugher, B.; Frieman, J.; Gerdes, D. W.; Goldstein, D. A.; Gruen, D.; Gruendl, R. A.; Honscheid, K.; James, D. J.; Jarvis, M.; Kent, S.; Kuehn, K.; Kuropatkin, N.; Lima, M.; March, M.; Martini, P.; Melchior, P.; Miller, C. J.; Miquel, R.; Nichol, R. C.; Ogando, R.; Plazas, A. A.; Reichardt, C. L.; Roodman, A.; Rozo, E.; Rykoff, E. S.; Sako, M.; Sanchez, E.; Scarpine, V.; Schubnell, M.; Sevilla-Noarbe, I.; Simard, G.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thomas, D.; Wechsler, R. H.; Weller, J.

2016-06-01

We measure the cross-correlation between weak lensing of galaxy images and of the cosmic microwave background (CMB). The effects of gravitational lensing on different sources will be correlated if the lensing is caused by the same mass fluctuations. We use galaxy shape measurements from 139 deg2 of the Dark Energy Survey (DES) Science Verification data and overlapping CMB lensing from the South Pole Telescope (SPT) and Planck. The DES source galaxies have a median redshift of zmed ˜ 0.7, while the CMB lensing kernel is broad and peaks at z ˜ 2. The resulting cross-correlation is maximally sensitive to mass fluctuations at z ˜ 0.44. Assuming the Planck 2015 best-fitting cosmology, the amplitude of the DES×SPT cross-power is found to be ASPT = 0.88 ± 0.30 and that from DES×Planck to be APlanck = 0.86 ± 0.39, where A = 1 corresponds to the theoretical prediction. These are consistent with the expected signal and correspond to significances of 2.9σ and 2.2σ, respectively. We demonstrate that our results are robust to a number of important systematic effects including the shear measurement method, estimator choice, photo-z uncertainty and CMB lensing systematics. We calculate a value of A = 1.08 ± 0.36 for DES×SPT when we correct the observations with a simple intrinsic alignment model. With three measurements of this cross-correlation now existing in the literature, there is not yet reliable evidence for any deviation from the expected LCDM level of cross-correlation. We provide forecasts for the expected signal-to-noise ratio of the combination of the five-year DES survey and SPT-3G.

Formulation of an experimental substructure model using a Craig-Bampton based transmission simulator

NASA Astrophysics Data System (ADS)

Kammer, Daniel C.; Allen, Mathew S.; Mayes, Randy L.

2015-12-01

Experimental-analytical substructuring is attractive when there is motivation to replace one or more system subcomponents with an experimental model. This experimentally derived substructure can then be coupled to finite element models of the rest of the structure to predict the system response. The transmission simulator method couples a fixture to the component of interest during a vibration test in order to improve the experimental model for the component. The transmission simulator is then subtracted from the tested system to produce the experimental component. The method reduces ill-conditioning by imposing a least squares fit of constraints between substructure modal coordinates to connect substructures, instead of directly connecting physical interface degrees of freedom. This paper presents an alternative means of deriving the experimental substructure model, in which a Craig-Bampton representation of the transmission simulator is created and subtracted from the experimental measurements. The corresponding modal basis of the transmission simulator is described by the fixed-interface modes, rather than free modes that were used in the original approach. These modes do a better job of representing the shape of the transmission simulator as it responds within the experimental system, leading to more accurate results using fewer modes. The new approach is demonstrated using a simple finite element model based example with a redundant interface.

Ocular Drug Delivery through pHEMA-Hydrogel Contact Lenses Co-Loaded with Lipophilic Vitamins

NASA Astrophysics Data System (ADS)

Lee, Dasom; Cho, Seungkwon; Park, Hwa Sung; Kwon, Inchan

2016-09-01

Ocular drug delivery through hydrogel contact lenses has great potential for the treatment of ocular diseases. Previous studies showed that the loading of lipophilic vitamin E to silicone-hydrogel contact lenses was beneficial in ocular drug delivery. We hypothesized that vitamin E loading to another type of popular hydrogel contact lenses, pHEMA-hydrogel contact lenses, improves ocular drug delivery by increasing the drug loading or the duration of drug release. Loading of vitamin E to pHEMA-hydrogel contact lenses significantly increased the loading of a hydrophilic drug surrogate (Alexa Fluor 488 dye) and two hydrophilic glaucoma drugs (timolol and brimonidine) to the lenses by 37.5%, 19.1%, and 18.7%, respectively. However, the release duration time was not significantly altered. Next, we hypothesized that the lipophilic nature of vitamin E attributes to the enhanced drug loading. Therefore, we investigated the effects of co-loading of another lipophilic vitamin, vitamin A, on drug surrogate delivery. We found out that vitamin A loading also increased the loading of the drug surrogate to pHEMA-hydrogel contact lenses by 30.3%. Similar to vitamin E loading, vitamin A loading did not significantly alter the release duration time of the drug or drug surrogate.

The MICE Grand Challenge light-cone simulation - III. Galaxy lensing mocks from all-sky lensing maps

NASA Astrophysics Data System (ADS)

Fosalba, P.; Gaztañaga, E.; Castander, F. J.; Crocce, M.

2015-02-01

In Paper I of this series, we presented a new N-body light-cone simulation from the MICE Collaboration, the MICE Grand Challenge (MICE-GC), containing about 70 billion dark-matter particles in a (3 h-1 Gpc)3 comoving volume, from which we built halo and galaxy catalogues using a Halo Occupation Distribution and Halo Abundance Matching technique, as presented in the companion Paper II. Given its large volume and fine mass resolution, the MICE-GC simulation also allows an accurate modelling of the lensing observables from upcoming wide and deep galaxy surveys. In the last paper of this series (Paper III), we describe the construction of all-sky lensing maps, following the `Onion Universe' approach, and discuss their properties in the light-cone up to z = 1.4 with sub-arcminute spatial resolution. By comparing the convergence power spectrum in the MICE-GC to lower mass-resolution (i.e. particle mass ˜1011 h-1 M⊙) simulations, we find that resolution effects are at the 5 per cent level for multipoles ℓ ˜ 103 and 20 per cent for ℓ ˜ 104. Resolution effects have a much lower impact on our simulation, as shown by comparing the MICE-GC to recent numerical fits by Takahashi. We use the all-sky lensing maps to model galaxy lensing properties, such as the convergence, shear, and lensed magnitudes and positions, and validate them thoroughly using galaxy shear auto and cross-correlations in harmonic and configuration space. Our results show that the galaxy lensing mocks here presented can be used to accurately model lensing observables down to arcminute scales. Accompanying this series of papers, we make a first public data release of the MICE-GC galaxy mock, the MICECAT v1.0, through a dedicated web-portal for the MICE simulations, http://cosmohub.pic.es, to help developing and exploiting the new generation of astronomical surveys.

Halo Pressure Profile through the Skew Cross-power Spectrum of the Sunyaev-Zel’dovich Effect and CMB Lensing in Planck

NASA Astrophysics Data System (ADS)

Timmons, Nicholas; Cooray, Asantha; Feng, Chang; Keating, Brian

2017-11-01

We measure the cosmic microwave background (CMB) skewness power spectrum in Planck, using frequency maps of the HFI instrument and the Sunyaev-Zel’dovich (SZ) component map. The two-to-one skewness power spectrum measures the cross-correlation between CMB lensing and the thermal SZ effect. We also directly measure the same cross-correlation using the Planck CMB lensing map and the SZ map and compare it to the cross-correlation derived from the skewness power spectrum. We model fit the SZ power spectrum and CMB lensing-SZ cross-power spectrum via the skewness power spectrum to constrain the gas pressure profile of dark matter halos. The gas pressure profile is compared to existing measurements in the literature including a direct estimate based on the stacking of SZ clusters in Planck.

Sustained Ocular Delivery of Ciprofloxacin Using Nanospheres and Conventional Contact Lens Materials

PubMed Central

Garhwal, Rahul; Shady, Sally F.; Ellis, Edward J.; Ellis, Jeanne Y.; Leahy, Charles D.; McCarthy, Stephen P.; Crawford, Kathryn S.

2012-01-01

Purpose. To formulate conventional contact lenses that incorporate nanosphere-encapsulated antibiotic and demonstrate that the lenses provide for sustained antibacterial activity. Methods. A copolymer composed of pullulan and polycaprolactone (PCL) was used to synthesize core-shell nanospheres that encapsulated ciprofloxacin. Bactericidal activity of the nanosphere-encapsulated ciprofloxacin (nanosphere/cipro) was tested by using liquid cultures of either Staphylococcus aureus or Pseudomonas aeruginosa. Nanosphere/cipro was then incorporated into HEMA-based contact lenses that were tested for growth inhibition of S. aureus or P. aeruginosa in liquid cultures inoculated daily with fresh bacteria. Lens designs included thin or thick lenses incorporating nanosphere/cipro and ciprofloxacin-HCl-soaked Acuvue lenses (Acuvue; Johnson & Johnson Vision Care, Inc., Jacksonville, FL). Results. Less than 2 μg/mL of nanosphere/cipro effectively inhibited the proliferation of cultures inoculated with 107 or 108 bacteria/mL of S. aureus and P. aeruginosa, respectively. HEMA-based contact lenses polymerized with nanosphere/cipro were transparent, effectively inhibited the proliferation of greater than 107/mL of bacteria added daily over 3 days of culture, and killed up to 5 × 109 total microbes in a single inoculation. A thicker lens design provided additional inhibition of bacterial growth for up to 96 hours. Conclusions. Core-shell nanospheres loaded with an antibiotic can be incorporated into a conventional, transparent contact lens and provide for sustained and effective bactericidal activity and thereby provide a new drug delivery platform for widespread use in treating ocular disorders. PMID:22266514

The effect of coloured overlays and lenses on reading: a systematic review of the literature.

PubMed

Griffiths, Philip G; Taylor, Robert H; Henderson, Lisa M; Barrett, Brendan T

2016-09-01

There are many anecdotal claims and research reports that coloured lenses and overlays improve reading performance. Here we present the results of a systematic review of this literature and examine the quality of the evidence. We systematically reviewed the literature concerning the effect of coloured lenses or overlays on reading performance by searching the PsychInfo, Medline and Embase databases. This revealed 51 published items (containing 54 data sets). Given that different systems are in use for issuing coloured overlays or lenses, we reviewed the evidence under four separate system headings (Intuitive, Irlen, Harris/Chromagen and Other), classifying each published item using the Cochrane Risk of Bias tool. Although the different colour systems have been subjected to different amounts of scientific scrutiny, the results do not differ according to the system type, or whether the sample under investigation was classified as having visual stress (or a similarly defined condition), reading difficulty, or both. The majority of studies are subject to 'high' or 'uncertain' risk of bias in one or more key aspects of study design or outcome, with studies at lower risk from bias providing less support for the benefit of coloured lenses/overlays on reading ability. While many studies report improvements with coloured lenses, the effect size is generally small and/or similar to the improvement found with a placebo condition. We discuss the strengths and shortcomings of the published literature and, whilst acknowledging the difficulties associated with conducting trials of this type, offer some suggestions about how future trials might be conducted. Consistent with previous reviews and advice from several professional bodies, we conclude that the use of coloured lenses or overlays to ameliorate reading difficulties cannot be endorsed and that any benefits reported by individuals in clinical settings are likely to be the result of placebo, practice or Hawthorne effects. © 2016 The Authors Ophthalmic & Physiological Optics © 2016 The College of Optometrists.

Effect of Masking on Subjective Responses to Daily Disposable Contact Lenses.

PubMed

Keir, Nancy; Luensmann, Doerte; Woods, Craig A; Bergenske, Peter; Fahmy, Mary; Fonn, Desmond

2016-08-01

To explore the effect of masking on subjective responses when wearing daily disposable (DD) contact lenses. In an adaptation phase, habitual wearers of Manufacturer-A (MFA) (n = 43) and Manufacturer-B (MFB) (n = 53) wore MFA-brand 1 or MFB-brand 1 DDs, respectively, for 30 days, open-label. Subjects were then randomly assigned to one of two experiments. Each experiment included two, 3-day crossover phases. An enhanced version of MFA and MFB lenses (MFA-brand 2 and MFB-brand 2) were worn contralaterally to evaluate potential differences in masking result between manufacturers. Experiment 1: subjects were fully masked to lens and packaging (FM) then unmasked (UM). Experiment 2: subjects were FM then partially masked using an over-label (PM). Comfort ratings (0-100) were recorded for each lens daily and preference between lenses was recorded on day 3 for each crossover phase. The mean difference between 0-100 ratings or preference when FM or PM versus UM for the same lens was considered a measurement of the effect associated with masking. The purpose of the study was withheld from subjects to minimize bias. The effect associated with masking for habitual wearers of MFA and MFB lenses was less than 1 out of 100 (0 ± 2.5) in both experiments. Fifty-eight subjects (60%) expressed no preference when FM. This decreased to 29 (30%) when UM or PM (proportion test, p < 0.001). Approximately half the subjects had a change in lens preference when they were UM or PM, primarily in favor of their habitual lens manufacturer. Masking did not have a measurable impact on 0-100 ratings with the DD lenses used in this study but did have an impact on lens preference. Subjects were more likely to express a preference when they handled the lenses and were exposed to the lens packaging and, in some cases, able to read the lens brand and lens manufacturer.

Non-Thermal Electromagnetic Radiation Damage to Lens Epithelium

PubMed Central

Bormusov, Elvira; P.Andley, Usha; Sharon, Naomi; Schächter, Levi; Lahav, Assaf; Dovrat, Ahuva

2008-01-01

High frequency microwave electromagnetic radiation from mobile phones and other modern devices has the potential to damage eye tissues, but its effect on the lens epithelium is unknown at present. The objective of this study was to investigate the non-thermal effects of high frequency microwave electromagnetic radiation (1.1GHz, 2.22 mW) on the eye lens epithelium in situ. Bovine lenses were incubated in organ culture at 35°C for 10-15 days. A novel computer-controlled microwave source was used to investigate the effects of microwave radiation on the lenses. 58 lenses were used in this study. The lenses were divided into four groups: (1) Control lenses incubated in organ culture for 10 to15 days. (2) Electromagnetic radiation exposure group treated with 1.1 GHz, 2.22 mW microwave radiation for 90 cycles of 50 minutes irradiation followed by 10 minutes pause and cultured up to 10 days. (3) Electromagnetic radiation exposure group treated as group 2 with 192 cycles of radiation and cultured for 15 days. (4) Lenses exposed to 39.5ºC for 2 hours 3 times with 24 hours interval after each treatment beginning on the second day of the culture and cultured for 11 days. During the culture period, lens optical quality was followed daily by a computer-operated scanning laser beam. At the end of the culture period, control and treated lenses were analyzed morphologically and by assessment of the lens epithelial ATPase activity. Exposure to 1.1 GHz, 2.22 mW microwaves caused a reversible decrease in lens optical quality accompanied by irreversible morphological and biochemical damage to the lens epithelial cell layer. The effect of the electromagnetic radiation on the lens epithelium was remarkably different from those of conductive heat. The results of this investigation showed that electromagnetic fields from microwave radiation have a negative impact on the eye lens. The lens damage by electromagnetic fields was distinctly different from that caused by conductive heat. PMID:19517034

Efficacy of Detergent and Water Versus Bleach for the Disinfection of Direct Contact Ophthalmic Lenses

PubMed Central

Abbey, Ashkan M.; Gregori, Ninel Z.; Surapaneni, Krishna; Miller, Darlene

2014-01-01

Purpose While manufacturers recommend cleaning ophthalmic lenses with detergent and water and then a specific disinfectant, disinfectants are rarely used in ophthalmic practices. The aim of this pilot study was to evaluate the efficacy of detergent and water versus bleach, a recommended disinfectant, to eliminate common ocular bacteria and viruses from ophthalmic lenses. Methods Three bacterial strains (Staphylococcus epidermidis, Corynebacterium straitum, and methicillin-resistant Staphylococcus aureus (MRSA) and two viral strains (adenovirus and herpes simplex virus (HSV) type-1) were individually inoculated to 20 gonioscopy and laser lenses. Lenses were washed with detergent and water and then disinfected with 10% bleach. All lenses were cultured after inoculation, after detergent and water, and after the bleach. Bacterial cultures in thioglycollate broth were observed for 3 weeks and viral cultures for 2 weeks. The presence of viruses was also detected by multiplex polymerase chain reaction (PCR). Results All 20 lenses inoculated with Staphylococcus epidermidis, Corynebacterium straitum, adenovirus, and HSV-1 showed growth after inoculation, but no growth after detergent/water and after the bleach. All lenses showed positive HSV and adenovirus PCR after inoculation and negative PCR after detergent/water and after bleach. All MRSA contaminated lenses showed growth after inoculation and no growth after detergent and water. However, one lens showed positive growth after bleach. Conclusions Cleaning with detergent and water appeared to effectively eliminate bacteria and viruses from the surface of contaminated ophthalmic lenses. Further studies are warranted to design practical disinfection protocols that minimize lens damage. PMID:24747806

Resolving z ~2 galaxy using adaptive coadded source plane reconstruction

NASA Astrophysics Data System (ADS)

Sharma, Soniya; Richard, Johan; Kewley, Lisa; Yuan, Tiantian

2018-06-01

Natural magnification provided by gravitational lensing coupled with Integral field spectrographic observations (IFS) and adaptive optics (AO) imaging techniques have become the frontier of spatially resolved studies of high redshift galaxies (z>1). Mass models of gravitational lenses hold the key for understanding the spatially resolved source–plane (unlensed) physical properties of the background lensed galaxies. Lensing mass models very sensitively control the accuracy and precision of source-plane reconstructions of the observed lensed arcs. Effective source-plane resolution defined by image-plane (observed) point spread function (PSF) makes it challenging to recover the unlensed (source-plane) surface brightness distribution.We conduct a detailed study to recover the source-plane physical properties of z=2 lensed galaxy using spatially resolved observations from two different multiple images of the lensed target. To deal with PSF’s from two data sets on different multiple images of the galaxy, we employ a forward (Source to Image) approach to merge these independent observations. Using our novel technique, we are able to present a detailed analysis of the source-plane dynamics at scales much better than previously attainable through traditional image inversion methods. Moreover, our technique is adapted to magnification, thus allowing us to achieve higher resolution in highly magnified regions of the source. We find that this lensed system is highly evident of a minor merger. In my talk, I present this case study of z=2 lensed galaxy and also discuss the applications of our algorithm to study plethora of lensed systems, which will be available through future telescopes like JWST and GMT.

Myopia correction in children: a meta-analysis.

PubMed

Cui, Yanhui; Li, Li; Wu, Qian; Zhao, Junyang; Chu, Huihui; Yu, Gang; Wei, Wenbin

2017-06-26

The purpose of this study was to conduct a meta-analysis comparing rigid gas permeable lenses (RGP) with soft contact lenses (SCL), spectacles and orthokeratology (OK) lenses for myopia control with respect to axial length elongation, spherical equivalent and measures of corneal curvature. Medline, Cochrane, EMBASE, and Google Scholar databases were searched to September 29, 2015 using the following keywords: rigid gas permeable contact lens; refractive error; and refractive abnormalities. Randomized controlled trials, two-arm prospective studies and retrospective studies of children with myopia treated with RGP lenses compared with spectacles, SCL, and OK lenses were included. Outcome measures were changes of axial length, spherical equivalent, flatter meridian, steeper meridian and corneal apical radius. Five studies were included. Three studies reported axial length change after 2-3 years of treatment with RGP lenses and SCL/spectacles and no difference between the groups was noted (pooled mean difference = -0.077, 95% confidence interval [CI]: -0.120 to 0.097, p = 0.840). Two studies reported a change of spherical equivalent after 2-3 years of treatment with RGP lenses and SCL/spectacles, and no difference between the groups was noted (pooled mean difference = 0.275, 95% CI: -0.390 to 0.941, p = 0.417). Two studies compared corneal curvature measures between RGP and OK lenses after 3-6 months of treatment and no differences in any measures of corneal curvature were seen. The effect of RGP lenses and SCL/spectacles on axial length elongation and spherical equivalent and of RGP and OK lenses on corneal curvature in children with myopia was similar.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batiste, Merida; Bentz, Misty C.; Manne-Nicholas, Emily R.

We present new bulge stellar velocity dispersion measurements for 10 active galaxies with secure M {sub BH} determinations from reverberation mapping. These new velocity dispersion measurements are based on spatially resolved kinematics from integral-field (IFU) spectroscopy. In all but one case, the field of view of the IFU extends beyond the effective radius of the galaxy, and in the case of Mrk 79 it extends to almost one half the effective radius. This combination of spatial resolution and field of view allows for secure determinations of stellar velocity dispersion within the effective radius for all 10 target galaxies. Spatially resolvedmore » maps of the first ( V ) and second ( σ {sub ⋆}) moments of the line of sight velocity distribution indicate the presence of kinematic substructure in most cases. In future projects we plan to explore methods of correcting for the effects of kinematic substructure in the derived bulge stellar velocity dispersion measurements.« less

The BRAVE Program. I. Improved Bulge Stellar Velocity Dispersion Estimates for a Sample of Active Galaxies

NASA Astrophysics Data System (ADS)

Batiste, Merida; Bentz, Misty C.; Manne-Nicholas, Emily R.; Onken, Christopher A.; Bershady, Matthew A.

2017-02-01

We present new bulge stellar velocity dispersion measurements for 10 active galaxies with secure MBH determinations from reverberation mapping. These new velocity dispersion measurements are based on spatially resolved kinematics from integral-field (IFU) spectroscopy. In all but one case, the field of view of the IFU extends beyond the effective radius of the galaxy, and in the case of Mrk 79 it extends to almost one half the effective radius. This combination of spatial resolution and field of view allows for secure determinations of stellar velocity dispersion within the effective radius for all 10 target galaxies. Spatially resolved maps of the first (V) and second (σ⋆) moments of the line of sight velocity distribution indicate the presence of kinematic substructure in most cases. In future projects we plan to explore methods of correcting for the effects of kinematic substructure in the derived bulge stellar velocity dispersion measurements.

Flat liquid crystal diffractive lenses with variable focus and magnification

NASA Astrophysics Data System (ADS)

Valley, Pouria

Non-mechanical variable lenses are important for creating compact imaging devices. Various methods employing dielectrically actuated lenses, membrane lenses, and liquid crystal lenses were previously proposed [1-4]. In This dissertation the design, fabrication, and characterization of innovative flat tunable-focus liquid crystal diffractive lenses (LCDL) are presented. LCDL employ binary Fresnel zone electrodes fabricated on Indium-Tin-Oxide using conventional micro-photolithography. The light phase can be adjusted by varying the effective refractive index of a nematic liquid crystal sandwiched between the electrodes and a reference substrate. Using a proper voltage distribution across various electrodes the focal length can be changed between several discrete values. Electrodes are shunted such that the correct phase retardation step sequence is achieved. If the number of 2pi zone boundaries is increased by a factor of m the focal length is changed from f to f/m based on the digitized Fresnel zone equation: f = rm2/2mlambda, where r m is mth zone radius, and lambda is the wavelength. The chromatic aberration of the diffractive lens is addressed and corrected by adding a variable fluidic lens. These LCDL operate at very low voltage levels (+/-2.5V ac input), exhibit fast switching times (20-150 ms), can have large apertures (>10 mm), and small form factor, and are robust and insensitive to vibrations, gravity, and capillary effects that limit membrane and dielectrically actuated lenses. Several tests were performed on the LCDL including diffraction efficiency measurement, switching dynamics, and hybrid imaging with a refractive lens. Negative focal lengths are achieved by adjusting the voltages across electrodes. Using these lenses in combination, magnification can be changed and zoom lenses can be formed. These characteristics make LCDL a good candidate for a variety of applications including auto-focus and zoom lenses in compact imaging devices such as camera phones. A business plan centered on this technology was developed as part of the requirements for the minor in entrepreneurship from the Eller College of Management. An industrial analysis is presented in this study that involves product development, marketing, and financial analyses (Appendix I).

Gravitational Lensing 2.0

NASA Astrophysics Data System (ADS)

Wittman, David M.; Benson, Bryant

2018-06-01

Weak lensing analyses use the image---the intensity field---of a distant galaxy to infer gravitational effects on that line of sight. What if we analyze the velocity field instead? We show that lensing imprints much more information onto a highly ordered velocity field, such as that of a rotating disk galaxy, than onto an intensity field. This is because shuffling intensity pixels yields a post-lensed image quite similar to an unlensed galaxy with a different orientation, a problem known as "shape noise." We show that velocity field analysis can eliminate shape noise and yield much more precise lensing constraints. Furthermore, convergence as well as shear can be constrained using the same target, and there is no need to assume the weak lensing limit of small convergence. We present Fisher matrix forecasts of the precision achievable with this method. Velocity field observations are expensive, so we derive guidelines for choosing suitable targets by exploring how precision varies with source parameters such as inclination angle and redshift. Finally, we present simulations that support our Fisher matrix forecasts.

Diamond Nanogel-Embedded Contact Lenses Mediate Lysozyme-Dependent Therapeutic Release

PubMed Central

2015-01-01

Temporarily implanted devices, such as drug-loaded contact lenses, are emerging as the preferred treatment method for ocular diseases like glaucoma. Localizing the delivery of glaucoma drugs, such as timolol maleate (TM), can minimize adverse effects caused by systemic administration. Although eye drops and drug-soaked lenses allow for local treatment, their utility is limited by burst release and a lack of sustained therapeutic delivery. Additionally, wet transportation and storage of drug-soaked lenses result in drug loss due to elution from the lenses. Here we present a nanodiamond (ND)-embedded contact lens capable of lysozyme-triggered release of TM for sustained therapy. We find that ND-embedded lenses composed of enzyme-cleavable polymers allow for controlled and sustained release of TM in the presence of lysozyme. Retention of drug activity is verified in primary human trabecular meshwork cells. These results demonstrate the translational potential of an ND-embedded lens capable of drug sequestration and enzyme activation. PMID:24506583

Cluster-lensing: A Python Package for Galaxy Clusters and Miscentering

NASA Astrophysics Data System (ADS)

Ford, Jes; VanderPlas, Jake

2016-12-01

We describe a new open source package for calculating properties of galaxy clusters, including Navarro, Frenk, and White halo profiles with and without the effects of cluster miscentering. This pure-Python package, cluster-lensing, provides well-documented and easy-to-use classes and functions for calculating cluster scaling relations, including mass-richness and mass-concentration relations from the literature, as well as the surface mass density {{Σ }}(R) and differential surface mass density {{Δ }}{{Σ }}(R) profiles, probed by weak lensing magnification and shear. Galaxy cluster miscentering is especially a concern for stacked weak lensing shear studies of galaxy clusters, where offsets between the assumed and the true underlying matter distribution can lead to a significant bias in the mass estimates if not accounted for. This software has been developed and released in a public GitHub repository, and is licensed under the permissive MIT license. The cluster-lensing package is archived on Zenodo. Full documentation, source code, and installation instructions are available at http://jesford.github.io/cluster-lensing/.

Demonstration of Cosmic Microwave Background Delensing Using the Cosmic Infrared Background.

PubMed

Larsen, Patricia; Challinor, Anthony; Sherwin, Blake D; Mak, Daisy

2016-10-07

Delensing is an increasingly important technique to reverse the gravitational lensing of the cosmic microwave background (CMB) and thus reveal primordial signals the lensing may obscure. We present a first demonstration of delensing on Planck temperature maps using the cosmic infrared background (CIB). Reversing the lensing deflections in Planck CMB temperature maps using a linear combination of the 545 and 857 GHz maps as a lensing tracer, we find that the lensing effects in the temperature power spectrum are reduced in a manner consistent with theoretical expectations. In particular, the characteristic sharpening of the acoustic peaks of the temperature power spectrum resulting from successful delensing is detected at a significance of 16σ, with an amplitude of A_{delens}=1.12±0.07 relative to the expected value of unity. This first demonstration on data of CIB delensing, and of delensing techniques in general, is significant because lensing removal will soon be essential for achieving high-precision constraints on inflationary B-mode polarization.

Modified Gravity and its test on galaxy clusters

NASA Astrophysics Data System (ADS)

Nieuwenhuizen, Theodorus M.; Morandi, Andrea; Limousin, Marceau

2018-05-01

The MOdified Gravity (MOG) theory of J. Moffat assumes a massive vector particle which causes a repulsive contribution to the tensor gravitation. For the galaxy cluster A1689 new data for the X-ray gas and the strong lensing properties are presented. Fits to MOG are possible by adjusting the galaxy density profile. However, this appears to work as an effective dark matter component, posing a serious problem for MOG. New gas and strong lensing data for the cluster A1835 support these conclusions and point at a tendency of the gas alone to overestimate the lensing effects in MOG theory.

A measurement of CMB cluster lensing with SPT and DES year 1 data

DOE PAGES

Baxter, E. J.; Raghunathan, S.; Crawford, T. M.; ...

2018-02-09

Clusters of galaxies gravitationally lens the cosmic microwave background (CMB) radiation, resulting in a distinct imprint in the CMB on arcminute scales. Measurement of this effect offers a promising way to constrain the masses of galaxy clusters, particularly those at high redshift. We use CMB maps from the South Pole Telescope Sunyaev-Zel'dovich (SZ) survey to measure the CMB lensing signal around galaxy clusters identified in optical imaging from first year observations of the Dark Energy Survey. The cluster catalog used in this analysis contains 3697 members with mean redshift ofmore » $$\\bar{z} = 0.45$$. We detect lensing of the CMB by the galaxy clusters at $$8.1\\sigma$$ significance. Using the measured lensing signal, we constrain the amplitude of the relation between cluster mass and optical richness to roughly $$17\\%$$ precision, finding good agreement with recent constraints obtained with galaxy lensing. The error budget is dominated by statistical noise but includes significant contributions from systematic biases due to the thermal SZ effect and cluster miscentering.« less

A measurement of CMB cluster lensing with SPT and DES year 1 data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baxter, E. J.; Raghunathan, S.; Crawford, T. M.

Clusters of galaxies gravitationally lens the cosmic microwave background (CMB) radiation, resulting in a distinct imprint in the CMB on arcminute scales. Measurement of this effect offers a promising way to constrain the masses of galaxy clusters, particularly those at high redshift. We use CMB maps from the South Pole Telescope Sunyaev-Zel'dovich (SZ) survey to measure the CMB lensing signal around galaxy clusters identified in optical imaging from first year observations of the Dark Energy Survey. The cluster catalog used in this analysis contains 3697 members with mean redshift ofmore » $$\\bar{z} = 0.45$$. We detect lensing of the CMB by the galaxy clusters at $$8.1\\sigma$$ significance. Using the measured lensing signal, we constrain the amplitude of the relation between cluster mass and optical richness to roughly $$17\\%$$ precision, finding good agreement with recent constraints obtained with galaxy lensing. The error budget is dominated by statistical noise but includes significant contributions from systematic biases due to the thermal SZ effect and cluster miscentering.« less

Evaluation of optical changes of three types of lenses: hard PMMA, hydrogel, and heparin surface modified hard lenses effected by silicone oil, used clinically as a substitute of the vitreous body.

PubMed

Prokopowicz, Magdalena; Czarnobaj, Katarzyna; Raczyńska, Krystyna; Łukasiak, Jerzy; Przyjazny, Andrzej

2002-01-01

The objective of these investigations was an in vitro evaluation whether silicone oil OXANE of viscosity 5700 cSt clinically used in eye surgery as a substitute of the vitreous body, being in contact with an artificial polymer lens used as an implant of human lens, causes the changes in its optical properties. The paper presents the results of spectral analysis of transmission of visible (VIS) radiation of three types of artificial lenses: hard PMMA, hydrogel, heparin surface modified (HSM) hard PMMA, and the same lenses damaged by YAG laser radiation with an energy increasing from 1.7 mJ to 3.7 mJ, exposed to clinically applied silicone oil. The studies were carried out, in two-week intervals, over a period of 20 weeks. Hard PMMA and HSM lenses were found not to have changed their optical properties after 20 weeks of exposure to silicone oil. The measured transmittance values were within the range of instrumental error (+/- 1%). Optical properties of hydrogel lenses exposed to silicone oils deteriorated with exposure and after 20-week exposure to silicone oil the average transmittance value decreased by about 18%, reaching its final value of 67.08 +/- 2.37% (RSD = 5.56%). A minimal decrease of the initial transmittance values was observed only for the lenses exposed to laser radiation of highest energy (3.7 mJ). After completed exposure to silicone oil, two kinds of lenses were found to have a slightly improved transmittance: hard PMMA lenses by about 4% and HSM lenses by about 2%. On the other hand, in case of hydrogel lenses the deterioration of optical properties to the extent comparable to that of hydrogel lenses not damaged by laser radiation was observed.

Models of the strongly lensed quasar DES J0408−5354

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnello, A.; et al.

We present gravitational lens models of the multiply imaged quasar DES J0408-5354, recently discovered in the Dark Energy Survey (DES) footprint, with the aim of interpreting its remarkable quad-like configuration. We first model the DES single-epochmore » $grizY$ images as a superposition of a lens galaxy and four point-like objects, obtaining spectral energy distributions (SEDs) and relative positions for the objects. Three of the point sources (A,B,D) have SEDs compatible with the discovery quasar spectra, while the faintest point-like image (G2/C) shows significant reddening and a `grey' dimming of $$\\approx0.8$$mag. In order to understand the lens configuration, we fit different models to the relative positions of A,B,D. Models with just a single deflector predict a fourth image at the location of G2/C but considerably brighter and bluer. The addition of a small satellite galaxy ($$R_{\\rm E}\\approx0.2$$") in the lens plane near the position of G2/C suppresses the flux of the fourth image and can explain both the reddening and grey dimming. All models predict a main deflector with Einstein radius between $1.7"$ and $2.0",$ velocity dispersion $267-280$km/s and enclosed mass $$\\approx 6\\times10^{11}M_{\\odot},$$ even though higher resolution imaging data are needed to break residual degeneracies in model parameters. The longest time-delay (B-A) is estimated as $$\\approx 85$$ (resp. $$\\approx125$$) days by models with (resp. without) a perturber near G2/C. The configuration and predicted time-delays of J0408-5354 make it an excellent target for follow-up aimed at understanding the source quasar host galaxy and substructure in the lens, and measuring cosmological parameters. We also discuss some lessons learnt from J0408-5354 on lensed quasar finding strategies, due to its chromaticity and morphology.« less

Design and fabrication of Si-HDPE hybrid Fresnel lenses for infrared imaging systems.

PubMed

Manaf, Ahmad Rosli Abdul; Sugiyama, Tsunetoshi; Yan, Jiwang

2017-01-23

In this work, novel hybrid Fresnel lenses for infrared (IR) optical applications were designed and fabricated. The Fresnel structures were replicated from an ultraprecision diamond-turned aluminum mold to an extremely thin layer (tens of microns) of high-density polyethylene polymer, which was directly bonded onto a flat single-crystal silicon wafer by press molding without using adhesives. Night mode imaging results showed that the fabricated lenses were able to visualize objects in dark fields with acceptable image quality. The capability of the lenses for thermography imaging was also demonstrated. This research provides a cost-effective method for fabricating ultrathin IR optical components.

The Origin of Gravitational Lensing: A Postscript to Einstein's 1936 Science Paper

PubMed

Renn; Sauer; Stachel

1997-01-10

Gravitational lensing, now taken as an important astrophysical consequence of the general theory of relativity, was found even before this theory was formulated but was discarded as a speculative idea without any chance of empirical confirmation. Reconstruction of some of Einstein's research notes dating back to 1912 reveals that he explored the possibility of gravitational lensing 3 years before completing his general theory of relativity. On the basis of preliminary insights into this theory, Einstein had already derived the basic features of the lensing effect. When he finally published the very same results 24 years later, it was only in response to prodding by an amateur scientist.

Astrophysical observations: lensing and eclipsing Einstein's theories.

PubMed

Bennett, Charles L

2005-02-11

Albert Einstein postulated the equivalence of energy and mass, developed the theory of special relativity, explained the photoelectric effect, and described Brownian motion in five papers, all published in 1905, 100 years ago. With these papers, Einstein provided the framework for understanding modern astrophysical phenomena. Conversely, astrophysical observations provide one of the most effective means for testing Einstein's theories. Here, I review astrophysical advances precipitated by Einstein's insights, including gravitational redshifts, gravitational lensing, gravitational waves, the Lense-Thirring effect, and modern cosmology. A complete understanding of cosmology, from the earliest moments to the ultimate fate of the universe, will require developments in physics beyond Einstein, to a unified theory of gravity and quantum physics.

Contact Lenses Wettability In Vitro: Effect of Surface-Active Ingredients

PubMed Central

Lin, Meng C.; Svitova, Tatyana F.

2010-01-01

Purpose To investigate the release of surface-active agents (surfactants) from unworn soft contact lenses and their influence on the lens surface wettability in vitro. Methods Surface tension (ST) of blister pack solutions was measured by pendant-drop technique. STs at the air-aqueous interface and contact angles (CAs) of four conventional and seven silicone hydrogel (SiH) soft contact lenses (SCLs) were evaluated in a dynamic-cycling regime using a modified captive-bubble tensiometer-goniometer. Measurements were performed immediately after removal from blister packs, and after soaking in a glass vial filled with a surfactant-free solution, which was replaced daily for one week. Lens surface wettability was expressed as adhesion energy (AE) according to Young’s equation. Results STs of all blister pack solutions were lower than the reference ST of pure water (72.5 mN/m), indicating the presence of surfactants. When lenses were depleted of surfactants by soaking, the STs of all studied lenses and advancing CAs of selected lenses increased (p < 0.001). Receding CAs of all studied lenses were 12° ± 5° and were not affected by the presence of surfactants. For most of the conventional lenses, the surface wettability was largely dependent on surfactants, and reduced significantly after surfactant depletion. In contrast, most SiH lenses exhibited stable and self-sustained surface wettability in vitro. Conclusions The manufacturer-added surfactants affected wetting properties of all studied SCLs, although to different degrees. PMID:20400924

Drug delivery through soft contact lenses.

PubMed Central

Jain, M. R.

1988-01-01

Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft contact lenses provided significantly higher drug penetration than subconjunctival therapy. Both modes of treatment provided therapeutically effective levels against most of the common ocular pathogens for varying intervals of 2 to 12 hours. PMID:3349016

On weak lensing shape noise

NASA Astrophysics Data System (ADS)

Niemi, Sami-Matias; Kitching, Thomas D.; Cropper, Mark

2015-12-01

One of the most powerful techniques to study the dark sector of the Universe is weak gravitational lensing. In practice, to infer the reduced shear, weak lensing measures galaxy shapes, which are the consequence of both the intrinsic ellipticity of the sources and of the integrated gravitational lensing effect along the line of sight. Hence, a very large number of galaxies is required in order to average over their individual properties and to isolate the weak lensing cosmic shear signal. If this `shape noise' can be reduced, significant advances in the power of a weak lensing surveys can be expected. This paper describes a general method for extracting the probability distributions of parameters from catalogues of data using Voronoi cells, which has several applications, and has synergies with Bayesian hierarchical modelling approaches. This allows us to construct a probability distribution for the variance of the intrinsic ellipticity as a function of galaxy property using only photometric data, allowing a reduction of shape noise. As a proof of concept the method is applied to the CFHTLenS survey data. We use this approach to investigate trends of galaxy properties in the data and apply this to the case of weak lensing power spectra.

Factors influencing bacterial adhesion to contact lenses.

PubMed

Dutta, Debarun; Cole, Nerida; Willcox, Mark

2012-01-01

The process of any contact lens related keratitis generally starts with the adhesion of opportunistic pathogens to contact lens surface. This article focuses on identifying the factors which have been reported to affect bacterial adhesion to contact lenses. Adhesion to lenses differs between various genera/species/strains of bacteria. Pseudomonas aeruginosa, which is the predominant causative organism, adheres in the highest numbers to both hydrogel and silicone hydrogel lenses in vitro. The adhesion of this strain reaches maximum numbers within 1h in most in vitro studies and a biofilm has generally formed within 24 h of cells adhering to the lens surface. Physical and chemical properties of contact lens material affect bacterial adhesion. The water content of hydroxyethylmethacrylate (HEMA)-based lenses and their iconicity affect the ability of bacteria to adhere. The higher hydrophobicity of silicone hydrogel lenses compared to HEMA-based lenses has been implicated in the higher numbers of bacteria that can adhere to their surfaces. Lens wear has different effects on bacterial adhesion, partly due to differences between wearers, responses of bacterial strains and the ability of certain tear film proteins when bound to a lens surface to kill certain types of bacteria.

Lensing bias to CMB polarization measurements of compensated isocurvature perturbations

NASA Astrophysics Data System (ADS)

Heinrich, Chen

2018-01-01

Compensated isocurvature perturbations (CIPs) are opposite spatial fluctuations in the baryon and dark matter (DM) densities. They arise in the curvaton model and some models of baryogenesis. While the gravitational effects of baryon fluctuations are compensated by those of DM, leaving no observable impacts on the cosmic microwave background (CMB) at first order, they modulate the sound horizon at recombination, thereby correlating CMB anisotropies at different multipoles. As a result, CIPs can be reconstructed using quadratic estimators similarly to CMB detection of gravitational lensing. Because of these similarities, however, the CIP estimators are biased with lensing contributions that must be subtracted. These lensing contributions for CMB polarization measurement of CIPs are found to roughly triple the noise power of the total CIP estimator on large scales. In addition, the cross power with temperature and E -mode polarization are contaminated by lensing-ISW (integrated Sachs-Wolfe) correlations and reionization-lensing correlations respectively. For a cosmic-variance-limited temperature and polarization experiment measuring out to multipoles lmax=2500 , the lensing noise raises the detection threshold by a factor of 1.5, leaving a 2.7 σ detection possible for the maximal CIP signal in the curvaton model.

Factors influencing bacterial adhesion to contact lenses

PubMed Central

Dutta, Debarun; Willcox, Mark

2012-01-01

The process of any contact lens related keratitis generally starts with the adhesion of opportunistic pathogens to contact lens surface. This article focuses on identifying the factors which have been reported to affect bacterial adhesion to contact lenses. Adhesion to lenses differs between various genera/species/strains of bacteria. Pseudomonas aeruginosa, which is the predominant causative organism, adheres in the highest numbers to both hydrogel and silicone hydrogel lenses in vitro. The adhesion of this strain reaches maximum numbers within 1h in most in vitro studies and a biofilm has generally formed within 24 h of cells adhering to the lens surface. Physical and chemical properties of contact lens material affect bacterial adhesion. The water content of hydroxyethylmethacrylate (HEMA)-based lenses and their iconicity affect the ability of bacteria to adhere. The higher hydrophobicity of silicone hydrogel lenses compared to HEMA-based lenses has been implicated in the higher numbers of bacteria that can adhere to their surfaces. Lens wear has different effects on bacterial adhesion, partly due to differences between wearers, responses of bacterial strains and the ability of certain tear film proteins when bound to a lens surface to kill certain types of bacteria. PMID:22259220

An assessment of the measurement of the Lense Thirring effect in the Earth gravity field, in reply to: “On the measurement of the Lense Thirring effect using the nodes of the LAGEOS satellites, in reply to “On the reliability of the so far performed tests for measuring the Lense Thirring effect with the LAGEOS satellites” by L. Iorio,” by I. Ciufolini and E. Pavlis

NASA Astrophysics Data System (ADS)

Iorio, L.

2007-03-01

In this paper we reply to recent claims by Ciufolini and Pavlis about certain aspects of the measurement of the general relativistic Lense-Thirring effect in the gravitational field of the Earth. (I) The proposal by such authors of using the existing satellites endowed with some active mechanism of compensation of the non-gravitational perturbations as an alternative strategy to improve the currently ongoing Lense-Thirring tests is unfeasible because of the impact of the uncancelled even zonal harmonics of the geopotential and of some time-dependent tidal perturbations. (II) It is shown that their criticisms about the possibility of using the existing altimeter Jason-1 and laser-ranged Ajisai satellites are groundless. (III) Ciufolini and Pavlis also claimed that we would have explicitly proposed to use the mean anomaly of the LAGEOS satellites in order to improve the accuracy of the Lense-Thirring tests. We prove that it is false. In regard to the mean anomaly of the LAGEOS satellites, Ciufolini himself did use such an orbital element in some previously published tests. About the latest test performed with the LAGEOS satellites, (IV) we discuss the cross-coupling between the inclination errors and the first even zonal harmonic as another possible source of systematic error affecting it with an additional 9% bias. (V) Finally, we stress the weak points of the claims about the origin of the two-nodes LAGEOS-LAGEOS II combination used in that test.

Long-term effects of the extended wear of senofilcon A silicone hydrogel contact lenses on ocular tissues.

PubMed

Guillon, Michel; Maïssa, Cécile

2010-12-01

The objective of the investigation was to show that, because of their overall properties, Acuvue® Oasys™ with Hydraclear™ Plus brand (senofilcon A) silicone hydrogel contact lenses achieve excellent ocular tissue tolerance during long-term extended wear. The investigation was a 2-year, prospective, extended wear investigation of senofilcon A silicone hydrogel contact lenses worn for up to 6 nights without removal. The 2-year results compared with the subjects' baseline ocular statuses on entering the study revealed: The quantification of the effects on the ocular tissues of 2 years of extended wear of senofilcon A, by mainly previously successful daily soft contact lens wearers, found an excellent biocompatibility. The results support the hypothesis that senofilcon A contact lenses, when worn on a 6-night/7-day extended wear regimen, maintain excellent long-term ocular tissue tolerance. Copyright © 2010 American Optometric Association. Published by Elsevier Inc. All rights reserved.

Mexican mestizo population sub-structure: effects on genetic and forensic statistical parameters.

PubMed

Noris, Gino; Santana, Carla; Meraz-Ríos, Marco Antonio; de Lourdes Munoz, María; Majluf-Cruz, Abraham; Magaña, Jonathan J; Granados, Julio; Quezada, Rosa; Revilla, María Cristina; Martínez-Salas, Sergio; Xihuitl, Salvador; Martínez de la Escalera, Gonzalo; Díaz-Badillo, Alvaro; Calderon-Aranda, Emma S; Gómez, Rocío

2012-12-01

Since Mexican mestizos are an admixed population, it is necessary to determine the effects that the substructure of the population has on genetic and forensic parameters. With this aim, a study was performed with 15 STR loci (CODIS plus D2S1338 and D19S433) on 1,640 unrelated Mexican mestizos. We determine allele and genotypic frequencies observing departure from Hardy-Weinberg expectation (12 out of 15 loci, with an excess of homozygotes, Fis > 0), as well as pairs of loci in an apparent linkage disequilibrium (13 of 92 loci). We conducted a test for genetic population stratification, the results show that the Mexican mestizo population is substructured into three subgroups, which are in HW and linkage equilibrium. The combination of the 15 loci in the whole population has high forensic efficiency with the capacity to genetically discriminate one individual in one quintillion (1/10(18)). Our data potentially validates the use of these 15 STR loci to establish forensic identity and parentage testing for legal purposes, and offers a powerful tool for genetic variation analysis. However, given that the population is stratified, we highly recommend applying a correction with the inbreeding coefficient in calculations of paternity and forensic studies to avoid erroneous assumptions.

A composite experimental dynamic substructuring method based on partitioned algorithms and localized Lagrange multipliers

NASA Astrophysics Data System (ADS)

Abbiati, Giuseppe; La Salandra, Vincenzo; Bursi, Oreste S.; Caracoglia, Luca

2018-02-01

Successful online hybrid (numerical/physical) dynamic substructuring simulations have shown their potential in enabling realistic dynamic analysis of almost any type of non-linear structural system (e.g., an as-built/isolated viaduct, a petrochemical piping system subjected to non-stationary seismic loading, etc.). Moreover, owing to faster and more accurate testing equipment, a number of different offline experimental substructuring methods, operating both in time (e.g. the impulse-based substructuring) and frequency domains (i.e. the Lagrange multiplier frequency-based substructuring), have been employed in mechanical engineering to examine dynamic substructure coupling. Numerous studies have dealt with the above-mentioned methods and with consequent uncertainty propagation issues, either associated with experimental errors or modelling assumptions. Nonetheless, a limited number of publications have systematically cross-examined the performance of the various Experimental Dynamic Substructuring (EDS) methods and the possibility of their exploitation in a complementary way to expedite a hybrid experiment/numerical simulation. From this perspective, this paper performs a comparative uncertainty propagation analysis of three EDS algorithms for coupling physical and numerical subdomains with a dual assembly approach based on localized Lagrange multipliers. The main results and comparisons are based on a series of Monte Carlo simulations carried out on a five-DoF linear/non-linear chain-like systems that include typical aleatoric uncertainties emerging from measurement errors and excitation loads. In addition, we propose a new Composite-EDS (C-EDS) method to fuse both online and offline algorithms into a unique simulator. Capitalizing from the results of a more complex case study composed of a coupled isolated tank-piping system, we provide a feasible way to employ the C-EDS method when nonlinearities and multi-point constraints are present in the emulated system.

[Effect of transparent yellow and orange colored contact lenses on color discrimination in the yellow color range].

PubMed

Schürer, M; Walter, A; Brünner, H; Langenbucher, A

2015-08-01

Colored transparent filters cause a change in color perception and have an impact on the perceptible amount of different colors and especially on the ability to discriminate between them. Yellow or orange tinted contact lenses worn to enhance contrast vision by reducing or blocking short wavelengths also have an effect on color perception. The impact of the yellow and orange tinted contact lenses Wöhlk SPORT CONTRAST on color discrimination was investigated with the Erlangen colour measurement system in a study with 14 and 16 subjects, respectively. In relation to a yellow reference color located at u' = 0.2487/v' = 0.5433, measurements of color discrimination thresholds were taken in up to 6 different color coordinate axes. Based on these thresholds, color discrimination ellipses were calculated. These results are given in the Derrington, Krauskopf and Lennie (DKL) color system. Both contact lenses caused a shift of the reference color towards higher saturated colors. Color discrimination ability with the yellow and orange colored lenses was significantly enhanced along the blue-yellow axis in comparison to the reference measurements without a tinted filter. Along the red-green axis only the orange lens caused a significant reduction of color discrimination threshold distance to the reference color. Yellow and orange tinted contact lenses enhance the ability of color discrimination. If the transmission spectra and the induced changes are taken into account, these results can also be applied to other filter media, such as blue filter intraocular lenses.

DEMNUni: ISW, Rees-Sciama, and weak-lensing in the presence of massive neutrinos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carbone, Carmelita; Petkova, Margarita; Dolag, Klaus, E-mail: carmelita.carbone@brera.inaf.it, E-mail: mpetkova@usm.lmu.de, E-mail: kdolag@mpa-garching.mpg.de

2016-07-01

We present, for the first time in the literature, a full reconstruction of the total (linear and non-linear) ISW/Rees-Sciama effect in the presence of massive neutrinos, together with its cross-correlations with CMB-lensing and weak-lensing signals. The present analyses make use of all-sky maps extracted via ray-tracing across the gravitational potential distribution provided by the ''Dark Energy and Massive Neutrino Universe'' (DEMNUni) project, a set of large-volume, high-resolution cosmological N-body simulations, where neutrinos are treated as separate collisionless particles. We correctly recover, at 1–2% accuracy, the linear predictions from CAMB. Concerning the CMB-lensing and weak-lensing signals, we also recover, with similarmore » accuracy, the signal predicted by Boltzmann codes, once non-linear neutrino corrections to HALOFIT are accounted for. Interestingly, in the ISW/Rees-Sciama signal, and its cross correlation with lensing, we find an excess of power with respect to the massless case, due to free streaming neutrinos, roughly at the transition scale between the linear and non-linear regimes. The excess is ∼ 5 – 10% at l ∼ 100 for the ISW/Rees-Sciama auto power spectrum, depending on the total neutrino mass M {sub ν}, and becomes a factor of ∼ 4 for M {sub ν} = 0.3 eV, at l ∼ 600, for the ISW/Rees-Sciama cross power with CMB-lensing. This effect should be taken into account for the correct estimation of the CMB temperature bispectrum in the presence of massive neutrinos.« less

Efficacy of detergent and water versus bleach for disinfection of direct contact ophthalmic lenses.

PubMed

Abbey, Ashkan M; Gregori, Ninel Z; Surapaneni, Krishna; Miller, Darlene

2014-06-01

Although manufacturers recommend cleaning ophthalmic lenses with detergent and water and then with a specific disinfectant, disinfectants are rarely used in ophthalmic practices. The aim of this pilot study was to evaluate the efficacy of detergent and water versus that of bleach, a recommended disinfectant, to eliminate common ocular bacteria and viruses from ophthalmic lenses. Three bacterial strains (Staphylococcus epidermidis, Corynebacterium straitum, and methicillin-resistant Staphylococcus aureus and 2 viral strains (adenovirus and herpes simplex virus [HSV] type-1) were individually inoculated onto 20 gonioscopy and laser lenses. The lenses were washed with detergent and water and then disinfected with 10% bleach. All the lenses were cultured after inoculation, after washing with detergent and water, and after disinfecting with the bleach. Bacterial cultures in thioglycollate broth were observed for 3 weeks, and viral cultures were observed for 2 weeks. The presence of viruses was also detected by multiplex polymerase chain reaction (PCR). All 20 lenses inoculated with S. epidermidis, C. straitum, adenovirus, and HSV-1 showed growth after inoculation but no growth after washing with detergent/water and after disinfecting with the bleach. All lenses showed positive HSV and adenovirus PCR results after inoculation and negative PCR results after washing with detergent/water and after disinfecting with bleach. All methicillin-resistant S. aureus-contaminated lenses showed growth after inoculation and no growth after washing with detergent and water. However, 1 lens showed positive growth after disinfecting with bleach. Cleaning with detergent and water seemed to effectively eliminate bacteria and viruses from the surface of contaminated ophthalmic lenses. Further studies are warranted to design practical disinfection protocols that minimize lens damage.

The M31 Pixel Lensing PLAN Campaign: MACHO Lensing and Self-lensing Signals

NASA Astrophysics Data System (ADS)

Calchi Novati, S.; Bozza, V.; Bruni, I.; Dall'Ora, M.; De Paolis, F.; Dominik, M.; Gualandi, R.; Ingrosso, G.; Jetzer, Ph.; Mancini, L.; Nucita, A.; Safonova, M.; Scarpetta, G.; Sereno, M.; Strafella, F.; Subramaniam, A.; Gould, A.; PLAN Collaboration

2014-03-01

We present the final analysis of the observational campaign carried out by the PLAN (Pixel Lensing Andromeda) collaboration to detect a dark matter signal in form of MACHOs through the microlensing effect. The campaign consists of about 1 month/year observations carried out over 4 years (2007-2010) at the 1.5 m Cassini telescope in Loiano (Astronomical Observatory of BOLOGNA, OAB) plus 10 days of data taken in 2010 at the 2 m Himalayan Chandra Telescope monitoring the central part of M31 (two fields of about 13' × 12.'6). We establish a fully automated pipeline for the search and the characterization of microlensing flux variations. As a result, we detect three microlensing candidates. We evaluate the expected signal through a full Monte Carlo simulation of the experiment completed by an analysis of the detection efficiency of our pipeline. We consider both "self lensing" and "MACHO lensing" lens populations, given by M31 stars and dark matter halo MACHOs, in M31 and the Milky Way, respectively. The total number of events is consistent with the expected self-lensing rate. Specifically, we evaluate an expected signal of about two self-lensing events. As for MACHO lensing, for full 0.5(10-2) M ⊙ MACHO halos, our prediction is for about four (seven) events. The comparatively small number of expected MACHO versus self-lensing events, together with the small number statistics at our disposal, do not enable us to put strong constraints on that population. Rather, the hypothesis, suggested by a previous analysis, on the MACHO nature of OAB-07-N2, one of the microlensing candidates, translates into a sizeable lower limit for the halo mass fraction in form of the would-be MACHO population, f, of about 15% for 0.5 M ⊙ MACHOs.

Discovery of New Retrograde Substructures: The Shards of ω Centauri?

NASA Astrophysics Data System (ADS)

Myeong, G. C.; Evans, N. W.; Belokurov, V.; Sanders, J. L.; Koposov, S. E.

2018-06-01

We use the SDSS-Gaia catalogue to search for substructure in the stellar halo. The sample comprises 62 133 halo stars with full phase space coordinates and extends out to heliocentric distances of ˜10 kpc. As actions are conserved under slow changes of the potential, they permit identification of groups of stars with a common accretion history. We devise a method to identify halo substructures based on their clustering in action space, using metallicity as a secondary check. This is validated against smooth models and numerical constructed stellar halos from the Aquarius simulations. We identify 21 substructures in the SDSS-Gaia catalogue, including 7 high significance, high energy and retrograde ones. We investigate whether the retrograde substructures may be material stripped off the atypical globular cluster ω Centauri. Using a simple model of the accretion of the progenitor of the ω Centauri, we tentatively argue for the possible association of up to 5 of our new substructures (labelled Rg1, Rg3, Rg4, Rg6 and Rg7) with this event. This sets a minimum mass of 5× 108M⊙ for the progenitor, so as to bring ω Centauri to its current location in action - energy space. Our proposal can be tested by high resolution spectroscopy of the candidates to look for the unusual abundance patterns possessed by ω Centauri stars.

Formulation of an experimental substructure model using a Craig-Bampton based transmission simulator

DOE PAGES

Kammer, Daniel C.; Allen, Matthew S.; Mayes, Randall L.

2015-09-26

An experimental–analytical substructuring is attractive when there is motivation to replace one or more system subcomponents with an experimental model. This experimentally derived substructure can then be coupled to finite element models of the rest of the structure to predict the system response. The transmission simulator method couples a fixture to the component of interest during a vibration test in order to improve the experimental model for the component. The transmission simulator is then subtracted from the tested system to produce the experimental component. This method reduces ill-conditioning by imposing a least squares fit of constraints between substructure modal coordinatesmore » to connect substructures, instead of directly connecting physical interface degrees of freedom. This paper presents an alternative means of deriving the experimental substructure model, in which a Craig–Bampton representation of the transmission simulator is created and subtracted from the experimental measurements. The corresponding modal basis of the transmission simulator is described by the fixed-interface modes, rather than free modes that were used in the original approach. Moreover, these modes do a better job of representing the shape of the transmission simulator as it responds within the experimental system, leading to more accurate results using fewer modes. The new approach is demonstrated using a simple finite element model based example with a redundant interface.« less

Mobility power flow analysis of coupled plate structure subjected to mechanical and acoustic excitation

NASA Technical Reports Server (NTRS)

Cuschieri, J. M.

1992-01-01

The mobility power flow approach that was previously applied in the derivation of expressions for the vibrational power flow between coupled plate substructures forming an L configuration and subjected to mechanical loading is generalized. Using the generalized expressions, both point and distributed mechanical loads on one or both of the plates can be considered. The generalized approach is extended to deal with acoustic excitation of one of the plate substructures. In this case, the forces (acoustic pressures) acting on the structure are dependent on the response of the structure because of the scattered pressure component. The interaction between the plate structure and the acoustic fluid leads to the derivation of a corrected mode shape for the plates' normal surface velocity and also for the structure mobility functions. The determination of the scattered pressure components in the expressions for the power flow represents an additional component in the power flow balance for the source plate and the receiver plate. This component represents the radiated acoustical power from the plate structure. For a number of coupled plate substrates, the acoustic pressure generated by one substructure will interact with the motion of another substructure. That is, in the case of the L-shaped plate, acoustic interaction exists between the two plate substructures due to the generation of the acoustic waves by each of the substructures. An approach to deal with this phenomena is described.

Formulation of an experimental substructure model using a Craig-Bampton based transmission simulator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kammer, Daniel C.; Allen, Matthew S.; Mayes, Randall L.

An experimental–analytical substructuring is attractive when there is motivation to replace one or more system subcomponents with an experimental model. This experimentally derived substructure can then be coupled to finite element models of the rest of the structure to predict the system response. The transmission simulator method couples a fixture to the component of interest during a vibration test in order to improve the experimental model for the component. The transmission simulator is then subtracted from the tested system to produce the experimental component. This method reduces ill-conditioning by imposing a least squares fit of constraints between substructure modal coordinatesmore » to connect substructures, instead of directly connecting physical interface degrees of freedom. This paper presents an alternative means of deriving the experimental substructure model, in which a Craig–Bampton representation of the transmission simulator is created and subtracted from the experimental measurements. The corresponding modal basis of the transmission simulator is described by the fixed-interface modes, rather than free modes that were used in the original approach. Moreover, these modes do a better job of representing the shape of the transmission simulator as it responds within the experimental system, leading to more accurate results using fewer modes. The new approach is demonstrated using a simple finite element model based example with a redundant interface.« less

Efficient RNA structure comparison algorithms.

PubMed

Arslan, Abdullah N; Anandan, Jithendar; Fry, Eric; Monschke, Keith; Ganneboina, Nitin; Bowerman, Jason

2017-12-01

Recently proposed relative addressing-based ([Formula: see text]) RNA secondary structure representation has important features by which an RNA structure database can be stored into a suffix array. A fast substructure search algorithm has been proposed based on binary search on this suffix array. Using this substructure search algorithm, we present a fast algorithm that finds the largest common substructure of given multiple RNA structures in [Formula: see text] format. The multiple RNA structure comparison problem is NP-hard in its general formulation. We introduced a new problem for comparing multiple RNA structures. This problem has more strict similarity definition and objective, and we propose an algorithm that solves this problem efficiently. We also develop another comparison algorithm that iteratively calls this algorithm to locate nonoverlapping large common substructures in compared RNAs. With the new resulting tools, we improved the RNASSAC website (linked from http://faculty.tamuc.edu/aarslan ). This website now also includes two drawing tools: one specialized for preparing RNA substructures that can be used as input by the search tool, and another one for automatically drawing the entire RNA structure from a given structure sequence.

A topological substructural molecular design approach for predicting mutagenesis end-points of alpha, beta-unsaturated carbonyl compounds.

PubMed

Pérez-Garrido, Alfonso; Helguera, Aliuska Morales; López, Gabriel Caravaca; Cordeiro, M Natália D S; Escudero, Amalio Garrido

2010-01-31

Chemically reactive, alpha, beta-unsaturated carbonyl compounds are common environmental pollutants able to produce a wide range of adverse effects, including, e.g. mutagenicity. This toxic property can often be related to chemical structure, in particular to specific molecular substructures or fragments (alerts), which can then be used in specialized software or expert systems for predictive purposes. In the past, there have been many attempts to predict the mutagenicity of alpha, beta-unsaturated carbonyl compounds through quantitative structure activity relationships (QSAR) but considering only one exclusive endpoint: the Ames test. Besides, even though those studies give a comprehensive understanding of the phenomenon, they do not provide substructural information that could be useful forward improving expert systems based on structural alerts (SAs). This work reports an evaluation of classification models to probe the mutagenic activity of alpha, beta-unsaturated carbonyl compounds over two endpoints--the Ames and mammalian cell gene mutation tests--based on linear discriminant analysis along with the topological Substructure molecular design (TOPS-MODE) approach. The obtained results showed the better ability of the TOPS-MODE approach in flagging structural alerts for the mutagenicity of these compounds compared to the expert system TOXTREE. Thus, the application of the present QSAR models can aid toxicologists in risk assessment and in prioritizing testing, as well as in the improvement of expert systems, such as the TOXTREE software, where SAs are implemented. 2009 Elsevier Ireland Ltd. All rights reserved.

Free Vibration Analysis of a Spinning Flexible DISK-SPINDLE System Supported by Ball Bearing and Flexible Shaft Using the Finite Element Method and Substructure Synthesis

NASA Astrophysics Data System (ADS)

JANG, G. H.; LEE, S. H.; JUNG, M. S.

2002-03-01

Free vibration of a spinning flexible disk-spindle system supported by ball bearing and flexible shaft is analyzed by using Hamilton's principle, FEM and substructure synthesis. The spinning disk is described by using the Kirchhoff plate theory and von Karman non-linear strain. The rotating spindle and stationary shaft are modelled by Rayleigh beam and Euler beam respectively. Using Hamilton's principle and including the rigid body translation and tilting motion, partial differential equations of motion of the spinning flexible disk and spindle are derived consistently to satisfy the geometric compatibility in the internal boundary between substructures. FEM is used to discretize the derived governing equations, and substructure synthesis is introduced to assemble each component of the disk-spindle-bearing-shaft system. The developed method is applied to the spindle system of a computer hard disk drive with three disks, and modal testing is performed to verify the simulation results. The simulation result agrees very well with the experimental one. This research investigates critical design parameters in an HDD spindle system, i.e., the non-linearity of a spinning disk and the flexibility and boundary condition of a stationary shaft, to predict the free vibration characteristics accurately. The proposed method may be effectively applied to predict the vibration characteristics of a spinning flexible disk-spindle system supported by ball bearing and flexible shaft in the various forms of computer storage device, i.e., FDD, CD, HDD and DVD.

Probing cluster potentials through gravitational lensing of background X-ray sources

NASA Technical Reports Server (NTRS)

Refregier, A.; Loeb, A.

1996-01-01

The gravitational lensing effect of a foreground galaxy cluster, on the number count statistics of background X-ray sources, was examined. The lensing produces a deficit in the number of resolved sources in a ring close to the critical radius of the cluster. The cluster lens can be used as a natural telescope to study the faint end of the (log N)-(log S) relation for the sources which account for the X-ray background.

Selection biases in empirical p(z) methods for weak lensing

DOE PAGES

Gruen, D.; Brimioulle, F.

2017-02-23

To measure the mass of foreground objects with weak gravitational lensing, one needs to estimate the redshift distribution of lensed background sources. This is commonly done in an empirical fashion, i.e. with a reference sample of galaxies of known spectroscopic redshift, matched to the source population. In this paper, we develop a simple decision tree framework that, under the ideal conditions of a large, purely magnitude-limited reference sample, allows an unbiased recovery of the source redshift probability density function p(z), as a function of magnitude and colour. We use this framework to quantify biases in empirically estimated p(z) caused bymore » selection effects present in realistic reference and weak lensing source catalogues, namely (1) complex selection of reference objects by the targeting strategy and success rate of existing spectroscopic surveys and (2) selection of background sources by the success of object detection and shape measurement at low signal to noise. For intermediate-to-high redshift clusters, and for depths and filter combinations appropriate for ongoing lensing surveys, we find that (1) spectroscopic selection can cause biases above the 10 per cent level, which can be reduced to ≈5 per cent by optimal lensing weighting, while (2) selection effects in the shape catalogue bias mass estimates at or below the 2 per cent level. Finally, this illustrates the importance of completeness of the reference catalogues for empirical redshift estimation.« less

Substructure of fuzzy dark matter haloes

NASA Astrophysics Data System (ADS)

Du, Xiaolong; Behrens, Christoph; Niemeyer, Jens C.

2017-02-01

We derive the halo mass function (HMF) for fuzzy dark matter (FDM) by solving the excursion set problem explicitly with a mass-dependent barrier function, which has not been done before. We find that compared to the naive approach of the Sheth-Tormen HMF for FDM, our approach has a higher cutoff mass and the cutoff mass changes less strongly with redshifts. Using merger trees constructed with a modified version of the Lacey & Cole formalism that accounts for suppressed small-scale power and the scale-dependent growth of FDM haloes and the semi-analytic GALACTICUS code, we study the statistics of halo substructure including the effects from dynamical friction and tidal stripping. We find that if the dark matter is a mixture of cold dark matter (CDM) and FDM, there will be a suppression on the halo substructure on small scales which may be able to solve the missing satellites problem faced by the pure CDM model. The suppression becomes stronger with increasing FDM fraction or decreasing FDM mass. Thus, it may be used to constrain the FDM model.

The effects of simultaneous dual focus lenses on refractive development in infant monkeys.

PubMed

Arumugam, Baskar; Hung, Li-Fang; To, Chi-Ho; Holden, Brien; Smith, Earl L

2014-10-16

We investigated the effects of two simultaneously imposed, competing focal planes on refractive development in monkeys. Starting at 3 weeks of age and continuing until 150 ± 4 days of age, rhesus monkeys were reared with binocular dual-focus spectacle lenses. The treatment lenses had central 2-mm zones of zero power and concentric annular zones with alternating powers of +3.0 diopter [D] and plano (pL or 0 D) (n = 7; +3D/pL) or -3.0 D and plano (n = 7; -3D/pL). Retinoscopy, keratometry, and A-scan ultrasonography were performed every 2 weeks throughout the treatment period. For comparison purposes data were obtained from monkeys reared with full field (FF) +3.0 (n = 4) or -3.0 D (n = 5) lenses over both eyes and 33 control animals reared with unrestricted vision. The +3 D/pL lenses slowed eye growth resulting in hyperopic refractive errors that were similar to those produced by FF+3 D lenses (+3 D/pL = +5.25 D, FF +3 D = +4.63 D; P = 0.32), but significantly more hyperopic than those observed in control monkeys (+2.50 D, P = 0.0001). One -3 D/pL monkey developed compensating axial myopia; however, in the other -3 D/pL monkeys refractive development was dominated by the zero-powered portions of the treatment lenses. The refractive errors for the -3 D/pL monkeys were more hyperopic than those in the FF -3 D monkeys (-3 D/pL = +3.13 D, FF -3D = -1.69 D; P = 0.01), but similar to those in control animals (P = 0.15). In the monkeys treated with dual-focus lenses, refractive development was dominated by the more anterior (i.e., relatively myopic) image plane. The results indicate that imposing relative myopic defocus over a large proportion of the retina is an effective means for slowing ocular growth. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

The Effects of Simultaneous Dual Focus Lenses on Refractive Development in Infant Monkeys

PubMed Central

Arumugam, Baskar; Hung, Li-Fang; To, Chi-ho; Holden, Brien; Smith, Earl L.

2014-01-01

Purpose. We investigated the effects of two simultaneously imposed, competing focal planes on refractive development in monkeys. Methods. Starting at 3 weeks of age and continuing until 150 ± 4 days of age, rhesus monkeys were reared with binocular dual-focus spectacle lenses. The treatment lenses had central 2-mm zones of zero power and concentric annular zones with alternating powers of +3.0 diopter [D] and plano (pL or 0 D) (n = 7; +3D/pL) or −3.0 D and plano (n = 7; −3D/pL). Retinoscopy, keratometry, and A-scan ultrasonography were performed every 2 weeks throughout the treatment period. For comparison purposes data were obtained from monkeys reared with full field (FF) +3.0 (n = 4) or −3.0 D (n = 5) lenses over both eyes and 33 control animals reared with unrestricted vision. Results. The +3 D/pL lenses slowed eye growth resulting in hyperopic refractive errors that were similar to those produced by FF+3 D lenses (+3 D/pL = +5.25 D, FF +3 D = +4.63 D; P = 0.32), but significantly more hyperopic than those observed in control monkeys (+2.50 D, P = 0.0001). One −3 D/pL monkey developed compensating axial myopia; however, in the other −3 D/pL monkeys refractive development was dominated by the zero-powered portions of the treatment lenses. The refractive errors for the −3 D/pL monkeys were more hyperopic than those in the FF −3 D monkeys (−3 D/pL = +3.13 D, FF −3D = −1.69 D; P = 0.01), but similar to those in control animals (P = 0.15). Conclusions. In the monkeys treated with dual-focus lenses, refractive development was dominated by the more anterior (i.e., relatively myopic) image plane. The results indicate that imposing relative myopic defocus over a large proportion of the retina is an effective means for slowing ocular growth. PMID:25324283

Microstructural evolution of garnet in a greenschist facies transpression zone

NASA Astrophysics Data System (ADS)

Massey, M. A.; Prior, D. J.; Moecher, D. P.

2007-12-01

Natural observations, laboratory experiments, and theoretical modeling support the interpretation of Grt plasticity in the lower crust and upper mantle; however, these processes are thought to be of little importance in shallow to middle crustal levels. Multiple textural varieties of Grt from the western boundary (Mt. Dumplin high strain zone) of an upper greenschist facies dextral transpression zone in southern New England, USA, display mesoscopic and microscopic evidence of syn-tectonic deformation and recrystallization. These microstructures were examined further by optical microscopy, electron probe microanalysis, orientation contrast imaging (OCI), and automated electron backscatter diffraction (EBSD) in order to understand possible low-grade deformation mechanisms and their significance. The N-S-striking shear zone dips steeply W, the mylonitic foliation is defined by aligned Ms- Chl-Rt, layers of Qtz and fine-grained Grt; Qtz-Chl-Ms and fine-grained Grt aggregates define lineations that plunge moderately SW. S-C-C¡¦ fabrics, asymmetric folds and porphyroclasts (delta- and sigma-type) are well developed on foliation-normal/lineation-parallel planes, and display sinistral kinematics; surfaces normal to foliation and normal to lineation exhibit strong asymmetries that indicate normal motion. Pre-tectonic mineral parageneses consist of St pseudomorphed by Chl-Ms-Ctd, Als pseudomorphed by Ms, and coarse-grained Grt and Ab porphyroclasts with associated asymmetric tails. Grt is manifest as three types: 1) equant Grt porphyroclasts; 2) elongate Grt aggregates consisting of 50-100 Ým equant Grt porphyroblasts; 3) type 1-type 2 transitional Grt morphology. Elemental x-ray mapping of Ca and Mn reveals at least two periods of growth in Grt types 1 and 3, and one period of growth in type 2 that correlates with type 1 and 3 rims; Mg is completely homogenized. Detailed mapping of type 3 Grt cores reveals ¡¥fractured¡¦ Ca-enriched cores ¡¥healed¡¦ with Ca- depleted composition. OCI of type 1 Grt shows no internal substructure. OCI of type 2 Grt also shows rare internal substructure (finer-grained equant inclusions with low angle boundaries), and EBSD shows aggregates have CPO symmetrical to tectonic fabric (parallel to lineation), high angle grain boundaries, and neighbor- neighbor grain pairs correlate with random grain pair distributions. Type 2 Grt also displays ¡¥stacking¡¦ structures where individual porphyroblasts are stacked vertically and grain boundaries are at low angle. OCI of type 3 Grt shows considerable internal substructure of three varieties: A) substructure boundaries that coincide with Ca-depleted compositions in cores; B) 50-100 Ým equant substructures included in rims; C) substructure boundaries in rims that ¡¥nucleate¡¦ from substructure A boundaries in cores. Detailed EBSD traverses across all substructure boundaries indicate rotation around rational crystallographic axes. Observations suggest that early amphibolite facies Grt (type 1 and 3 cores) was deformed non-penetratively by plastic deformation or sub-critical fracture (type 3 Grt, substructure A). Type 2 Grt nucleated pre- to syn-tectonically, at least partially through the consumption of type 3 Grt porphyroclasts, and was included in type 1 and 3 rims by rigid body rotations (substructure B). Substructures C in type 3 Grt rims are inherited from pre-existing crystallographic anisotropies in cores (substructure A). Additionally, type 2 Grt was deformed syn-tectonically to produce CPOs, likely as a result of flattening associated with transpression.

Spatial Substructure in the M87 Globular Cluster System

NASA Astrophysics Data System (ADS)

Feng, Yuting; Zhang, Yunhao; Guhathakurta, Puragra; Peng, Eric; Lim, Sungsoon

2018-01-01

Based on the observation of Next Generation Virgo Cluster Survey (NGVS) project, we obtained the u,g,r,i,z and Ks band photometric information of all the objects in the 2 degree × 2 degree area (Pilot Region) around M87, the major subcluster of Virgo. By adapting an Extreme Deconvolution method, which classifies objects into Globular Clusters (GCs), galaxies and foreground stars with their color and morphology data, we got a purer-than-ever GC distribution map with a depth to gmag=25 in Pilot Region. After masking galaxy GCs, smoothing with a 10arcmin Gaussian kernel and performing a flat field correction, we show the GC density map of M87, and got a good sersic fitting of GC radial distribution with a sersic index~2.2 in the central ellipse part (45arcmin semi major axis area of M87). We quantitatively compared our GC sample with a substructure-free mock data set, which was generated from the smoothed density map as well as the sersic fitting, by calculating the 2 point correlation function (TPCF) value in different parts of the map. After separately performing such comparison with mocks based on different galaxy masking radii which vary from 4 times g band effective radius to 10, we found signals of remarkable spatial enhancement in certain directions in the central ellipse of M87, as well as halo substructures shown as lumpiness and holes in the outer region. We present the estimated scales of these substructures from the TPCF results, and, managed to locate them with a statistical analysis of the pixelized GC map. Apart from all results listed above, we discuss the constant, extra-galactic substructure signal at a scale of ~3kpc, which does not diminish with masking sizes, as the evidence of merging and accretion history of M87.

The Response of Ω-Loop D Dynamics to Truncation of Trimethyllysine 72 of Yeast Iso-1-cytochrome c Depends on the Nature of Loop Deformation

PubMed Central

McClelland, Levi J.; Seagraves, Sean M.; Khan, Khurshid Alam; Cherney, Melisa M.; Bandi, Swati; Culbertson, Justin E.; Bowler, Bruce E.

2015-01-01

Trimethyllysine 72 (tmK72) has been suggested to play a role in sterically constraining the heme crevice dynamics of yeast iso-1-cytochrome c mediated by the Ω-loop D cooperative substructure (residues 70 to 85). A tmK72A mutation causes a gain in peroxidase activity, a function of cytochrome c that is important early in apoptosis. More than one higher energy state is accessible for the Ω-loop D substructure via tier 0 dynamics. Two of these are alkaline conformers mediated by Lys73 and Lys79. In the current work, the effect of the tmK72A mutation on the thermodynamic and kinetic properties of wild type iso-1-cytochrome c (yWT versus WT*) and on variants carrying a K73H mutation (yWT/K73H versus WT*/K73H) is studied. Whereas the tmK72A mutation confers increased peroxidase activity in wild type yeast iso-1-cytochrome c and increased dynamics for formation of a previously studied His79-heme alkaline conformer, the tmK72A mutation speeds return of the His73-heme alkaline conformer to the native state through destabilization of the His73-heme alkaline conformer relative to the native conformer. These opposing behaviors demonstrate that the response of the dynamics of a protein substructure to mutation depends on the nature of the perturbation to the substructure. For a protein substructure which mediates more than one function of a protein through multiple non-native structures, a mutation could change the partitioning between these functions. The current results suggest that the tier 0 dynamics of Ω-loop D that mediates peroxidase activity has similarities to the tier 0 dynamics required to form the His79-heme alkaline conformer. PMID:25948392

Differential effects of black currant anthocyanins on diffuser- or negative lens-induced ocular elongation in chicks.

PubMed

Iida, Hiroyuki; Nakamura, Yuko; Matsumoto, Hitoshi; Kawahata, Keiko; Koga, Jinichiro; Katsumi, Osamu

2013-01-01

To compare the inhibitory effects of 4 different types of black currant anthocyanins (BCAs) on ocular elongation in 2 different chick myopia models. In the first model, diffusers were used to induce form vision deprivation. In the second model, negative (-8D) spherical lenses were used to create a defocused retinal image. Either the diffusers or the -8D lenses were placed on the right eyes of 8-day-old chicks for 4 days. Ocular biometric components were measured using an A-scan ultrasound instrument on the third day after application of either the diffusers or -8D lenses. Interocular differences (globe component dimensions of the right diffuser or eyes covered with -8D lenses minus those of the open left eyes) were considered to evaluate the effect of BCAs. The BCAs used were cyanidin-3-glucoside (C3G), cyanidin-3-rutinoside (C3R), delphinidin-3-rutinoside (D3R), and delphinidin-3-glucoside (D3G). Each anthocyanin was administered intravenously at a dose of 0.027 μmol/kg once a day for 3 days. Compared to the vehicle treatment, C3G and C3R treatments significantly reduced both differential increases (positive values of interocular differences) of the ocular axial length induced by diffusers or -8D lenses (diffusers; C3G, C3R, and control: 0.32±0.051 mm, P<0.05; 0.25±0.034 mm, P<0.01; and 0.52±0.047 mm, -8D lenses; C3G, C3R, and control: 0.25±0.049 mm, P<0.01; 0.17±0.049 mm, P<0.001; and 0.50±0.056 mm). In contrast, compared to vehicle treatment, D3R treatment significantly decreased the differential increases in the ocular axial length only in chicks with myopia induced by -8D lenses (D3R and control: 0.17±0.049 mm and 0.50±0.056 mm, P<0.001). D3G did not inhibit the differential increase in the ocular axial length induced by either diffusers or -8D lenses. This study showed that the 4 tested BCAs had different effects on the 2 different experimental models of myopia.

Process equipped with a sloped UV lamp for the fabrication of gradient-refractive-index lenses.

PubMed

Liu, Jui-Hsiang; Chiu, Yi-Hong

2009-05-01

In this investigation, a method for the preparation of gradient-refractive-index (GRIN) lenses by UV-energy-controlled polymerization has been developed. A glass reaction tube equipped with a sloped UV lamp was designed. Methyl methacrylate and diphenyl sulfide were used as the reactive monomer and nonreactive dopant, respectively. Ciba IRGACURE 184 (1-hydroxy-cyclohexyl-phenyl-ketone) was used as the initiator. The effects of initiator concentration, the addition of acrylic polymers, and the preparation conditions on the optical characteristics of the GRIN lenses produced by this method were also investigated. Refractive index distributions and image transmission properties were estimated for all GRIN lenses prepared.

In Vitro Effect of Lysozyme on Albumin Deposition to Hydrogel Contact Lens Materials.

PubMed

Babaei Omali, Negar; Subbaraman, Lakshman N; Heynen, Miriam; Fadli, Zohra; Coles-Brennan, Chantal; Jones, Lyndon W

2017-11-01

Albumin deposition on contact lenses could be detrimental to contact lens (CL) wear because this may increase the risk of bacterial binding and reduce comfort. Lysozyme deposition on selected lens materials would reduce albumin deposition on lenses. This study aims to determine if lysozyme deposition on CLs could act as a barrier against subsequent albumin adsorption, using an in vitro model. Six hydrogel CL materials (etafilcon A, polymacon, nelfilcon A, omafilcon A, ocufilcon B, and nesofilcon A) were evaluated. Four CLs of each type were soaked in lysozyme solution for 16 hours at 37°C. Lysozyme-coated lenses were then placed in vials with 1.5 mL of artificial tear solution containing I-labeled albumin for 16 hours at 37°C with shaking. Four uncoated lenses of each type were used as controls. Lenses soaked in radiolabeled albumin were rinsed in a phosphate-buffered saline solution, and radioactive counts were measured directly on lenses using a gamma counter. Albumin uptake on lenses was measured using a calibration curve by plotting radioactive counts versus protein concentration. Results are reported as mean ± SD. Lysozyme-coated etafilcon A lenses exhibited lower levels of deposited albumin than uncoated etafilcon A lenses (58 ± 12 vs. 84 ± 5 ng/lens; P < .05). There were no differences in albumin adsorption between control (uncoated) and lysozyme-coated polymacon (105 ± 10 vs. 110 ± 34 ng/lens), nelfilcon A (51 ± 7 vs. 42 ± 20 ng/lens), omafilcon A (90 ± 20 vs. 80 ± 38 ng/lens), ocufilcon B (87 ± 20 vs. 115 ± 50 ng/lens), and nesofilcon A (170 ± 29 vs. 161 ± 10 ng/lens) lens materials (P > .05). Uncoated nesofilcon A lenses deposited the highest amount of albumin when compared with other uncoated lenses (P < .05). This study demonstrates that lysozyme deposited onto etafilcon A resists the deposition of albumin, which may potentially be beneficial to CL wearers.

Fluid Lensing and Applications to Remote Sensing of Aquatic Environments

NASA Technical Reports Server (NTRS)

Chirayath, Ved

2017-01-01

The use of fluid lensing technology on UAVs is presented as a novel means for 3D imaging of aquatic ecosystems from above the water's surface at the centimeter scale. Preliminary results are presented from airborne fluid lensing campaigns conducted over the coral reefs of Ofu Island, American Samoa (2013) and the stromatolite reefs of Shark Bay, Western Australia (2014), covering a combined area of 15km2. These reef ecosystems were revealed with centimetre-scale 2D resolution, and an accompanying 3D bathymetry model was derived using fluid lensing, Structure from Motion and UAV position data. Data products were validated from in-situ survey methods including underwater calibration targets, depth measurements and millimetre-scale high-dynamic range gigapixel photogrammetry. Fluid lensing is an experimental technology that uses water transmitting wavelengths to passively image underwater objects at high-resolution by exploiting time-varying optical lensing events caused by surface waves. Fluid lensing data are captured from low-altitude, cost-effective electric UAVs to achieve multispectral imagery and bathymetry models at the centimetre scale over regional areas. As a passive system, fluid lensing is presently limited by signal-to-noise ratio and water column inherent optical properties to approximately 10 m depth over visible wavelengths in clear waters. The datasets derived from fluid lensing present the first centimetre-scale images of a reef acquired from above the ocean surface, without wave distortion. The 3D multispectral data distinguish coral, fish and invertebrates in American Samoa, and reveal previously undocumented, morphologically distinct, stromatolite structures in Shark Bay. These findings suggest fluid lensing and multirotor electric drones represent a promising advance in the remote sensing of aquatic environments at the centimetre scale, or 'reef scale' relevant to the conservation of reef ecosystems. Pending further development and validation of fluid lensing methods, these technologies present a solution for large-scale 3D surveys of shallow aquatic habitats with centimetre-scale spatial resolution and hourly temporal sampling.

5. DOWNSTREAM ELEVATION OF BRIDGE AND SUBSTRUCTURE (with graduated meter ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. DOWNSTREAM ELEVATION OF BRIDGE AND SUBSTRUCTURE (with graduated meter pole); VIEW TO NORTH-NORTHEAST. - Auwaiakeakua Bridge, Spanning Auwaiakekua Gulch at Mamalahoa Highway, Waikoloa, Hawaii County, HI

Microbial changes in conjunctival flora with 30-day continuous-wear silicone hydrogel contact lenses.

PubMed

Iskeleli, Güzin; Bahar, Hrisi; Eroglu, Ebru; Torun, Muzeyyen Mamal; Ozkan, Sehirbay

2005-05-01

To determine the effect of 30-day continuous-wear silicone hydrogel contact lenses on the conjunctival flora in asymptomatic wearers. The authors studied 29 eyes of 15 patients wearing Focus NIGHT & DAY silicone hydrogel contact lenses for up to 30 nights of continuous wear. The average age of the patients was 25.54 +/- 8.98 years. Cultures of the inferior cul-de-sac were taken bilaterally from all eyes, before and after lens wear in asymptomatic patients. The isolation and identification of bacteria were made by standard clinical laboratory methods. The number of eyes whose conjunctival cultures were sterile before using the lenses significantly decreased (P = 0.0005), and the number of eyes with a growth of coagulase-negative staphylococci and diphtheroid rods in their conjunctival cultures significantly increased after using these lenses (P = 0.001 and P = 0.031, respectively). Conversely, a statistically significant difference was not found in the number of eyes that carried Propionibacterium acnes and Fusobacterium nucleatum in their conjunctival cultures before and after using the 30-day continuous-wear silicone hydrogel lenses (P = 0.998 and P = 0.488, respectively). The results suggest that the sterility of the conjunctiva significantly decreased after using 30-day continuous-wear silicone hydrogel contact lenses. In addition, the number of bacteria of the normal conjunctival flora significantly increased after the use of these lenses. Contamination by the bacteria of the eyelids may be a possible colonization factor in this study group. Therefore, it is appropriate to examine the patients who wear these lenses more frequently.

Periodic self-lensing from accreting massive black hole binaries

NASA Astrophysics Data System (ADS)

D'Orazio, Daniel J.; Di Stefano, Rosanne

2018-03-01

Nearly 150 massive black hole binary (MBHB) candidates at sub-pc orbital separations have been reported in recent literature. Nevertheless, the definitive detection of even a single such object remains elusive. If at least one of the black holes is accreting, the light emitted from its accretion disc will be lensed by the other black hole for binary orbital inclinations near to the line of sight. This binary self-lensing could provide a unique signature of compact MBHB systems. We show that, for MBHBs with masses in the range 106-1010 M⊙ and with orbital periods less than ˜10 yr, strong lensing events should occur in one to 10s of per cent of MBHB systems that are monitored for an entire orbit. Lensing events will last from days for the less massive, shorter period MBHBs to a year for the most massive ˜10 year orbital period MBHBs. At small inclinations of the binary orbit to the line of sight, lensing must occur and will be accompanied by periodicity due to the relativistic Doppler boost. Flares at the same phase as the otherwise average flux of the Doppler modulation would be a smoking gun signature of self-lensing and can be used to constrain binary parameters. For MBHBs with separation ≳100 Schwarzschild radii, we show that finite-sized source effects could serve as a probe of MBH accretion disc structure. Finally, we stress that our lensing probability estimate implies that ˜10 of the known MBHB candidates identified through quasar periodicity should exhibit strong lensing flares.

Contact lens deposits, adverse responses, and clinical ocular surface parameters.

PubMed

Zhao, Zhenjun; Naduvilath, Thomas; Flanagan, Judith L; Carnt, Nicole A; Wei, Xiaojia; Diec, Jennie; Evans, Vicki; Willcox, Mark D P

2010-09-01

To correlate clinical responses during contact lens wear with the amount of protein or cholesterol extracted from lenses after wear. Clinical parameters, including adverse response rates and corneal staining, and symptomatology rating during lens wear were collected from a series of clinical tests comprising four different silicone hydrogel lenses with four different multipurpose solutions. To test for correlates, the amount of total protein or cholesterol extracted from lenses after daily wear were compared statistically to clinical parameters. The amount of protein (p = 0.008) or cholesterol (p = 0.01) extracted from lenses was higher for those subjects who showed solution-induced corneal staining. Amount of protein extracted was correlated (p < 0.01) with conjunctival staining (R = -0.23), lens front surface wetting (r = 0.14), and lens fit tightness (R = -0.20). These clinical parameters accounted for 48% of lens protein deposition. The amount of cholesterol extracted from lenses was much more weakly associated with clinical variables. Amount of protein or cholesterol extracted from lenses was not associated with the production of any corneal infiltrative or mechanical adverse event during wear and was only very weakly correlated with insertion comfort of lenses. These results suggest that there may be no physiologically relevant consequence of cholesterol depositing on silicone hydrogel lenses. The amount of protein that deposits onto silicone hydrogel lenses during wear may have more affect on lens performance on-eye. However, the correlations were generally small and may still not indicate any causative relevant physiological response. Further work is required to determine whether there is any direct causative effect to support these correlative findings.

Cosmological Studies with Galaxy Clusters, Active Galactic Nuclei, and Strongly Lensed Quasars

NASA Astrophysics Data System (ADS)

Rumbaugh, Nicholas Andrew

The large-scale structure (LSS) of the universe provides scientists with one of the best laboratories for studying Lambda Cold Dark Matter (LambdaCDM) cosmology. Especially at high redshift, we see increased rates of galaxy cluster and galaxy merging in LSS relative to the field, which is useful for studying the hierarchical merging predicted by LambdaCDM. The largest identified bound structures, superclusters, have not yet virialized. Despite the wide range of dynamical states of their constituent galaxies, groups, and clusters, they are all still actively evolving, providing an ideal laboratory in which to study cluster and galaxy evolution. In this dissertation, I present original research on several aspects of LSS and LambdaCDM cosmology. Three separate studies are included, each one focusing on a different aspect. In the first study, we use X-ray and optical observations from nine galaxy clusters at high redshift, some embedded in larger structures and some isolated, to study their evolutionary states. We extract X-ray gas temperatures and luminosities as well as optical velocity dispersions. These cluster properties are compared using low-redshift scaling relations. In addition, we employ several tests of substructure, using velocity histograms, Dressler-Shectman tests, and centroiding offsets. We conclude that two clusters out of our sample are most likely unrelaxed, and find support for deviations from self-similarity in the redshift evolution of the Lx-T relation. Our numerous complementary tests of the evolutionary state of clusters suggest potential under-estimations of systematic error in studies employing only a single such test. In the second study, we use multi-band imaging and spectroscopy to study active galactic nuclei (AGN) in high-redshift LSS. The AGN were identified using X-ray imaging and matched to optical catalogs that contained spectroscopic redshifts to identify members of the structures. AGN host galaxies tended to be associated with the transitional `green valley' on a color-magnitude diagram. Spectral analysis of the AGN hosts showed that the average host galaxy had either on-going or recent star formation, and was younger than the average galaxy, across all LSS in our sample. We further subdivided our sample in two based on the average evolutionary state of the LSS. The AGN in the more evolved structures had lower X-ray luminosities and longer times since last starburst. These results provide some evidence for merger-based AGN triggering, although other mechanisms, and possibly more than one, could be responsible. In the third study, we probed LambdaCDM cosmology from a different angle. An important part of the model is the cosmological parameters that define our universe. As such, probes that can more accurately and precisely measure these parameters, such as H0 and the dark energy equation of state, w, can allow us to more closely inspect the model. Strongly-lensed quasars provide one such probe, and we sought to perform the first step in using them for cosmological inference, which is to measure the time delays between strongly lensed images. We performed radio monitoring campaigns on six strongly lensed quasars using the Very Large Array. Lightcurves were extracted for each lensed image and analyzed for intrinsic variability. Two lensed quasars showed strong time variations, but the variations were linear in time, preventing precise time delay measurements due to a degeneracy with the magnifications. These results suggest most of the systems should be targeted for followup monitoring, and we estimate that time delays can be measured for the most variable systems with precision of 0.5 to 3.5 days with two more seasons of monitoring. In a joint fit with previously studied systems, these measurements could tighten constraints on H 0 by up to ~1.4.

[Effects of orthokeratology lenses on the magnitude of accommodative lag and accommodativeconvergence/accommodation].

PubMed

Ren, Qiujin; Yue, Hui; Zhou, Qing

2016-02-01

To evaluate the change in accommodative lag and accommodation convergence/accommodation (AC/A) after patients with myopia wear orthokeratology lenses. 
 A total of 48 myopic subjects (a test group), who wore orthokeratology lenses regularly, and 48 myopic subjects (a control group), who wore spectacles regularly, were enrolled for this study from January 2011 to January 2013 in Optometric Center, the Forth Hospital of Changsha. Accommodative lag was measured by fused cross cylinder method, where the patients should gaze at the front optotypes 40 cm away. Gradient of the AC/A ratio was measured by Von Grafe method to check closer distance heterophoria. Accommodative lag and AC/A ratio were analyzed by statistics.
 After 1-year follow-up, accommodative lag and AC/A rate in patients with low or moderate myopia in the test group was decreased in 1, 3, 6 months or 1 year compared with that in the control group (P<0.05). 
 Compared with spectacles, orthokeratology lenses are able to decrease accommodative lag and high AC/A rate in patients with low or moderate myopia. The relationship between accommodation and convergence is improved by orthokeratology lenses. Orthokeratology is an effective way to control myopia.

Binary Sources and Binary Lenses in Microlensing Surveys of MACHOs

NASA Astrophysics Data System (ADS)

Petrovic, N.; Di Stefano, R.; Perna, R.

2003-12-01

Microlensing is an intriguing phenomenon which may yield information about the nature of dark matter. Early observational searches identified hundreds of microlensing light curves. The data set consisted mainly of point-lens light curves and binary-lens events in which the light curves exhibit caustic crossings. Very few mildly perturbed light curves were observed, although this latter type should constitute the majority of binary lens light curves. Di Stefano (2001) has suggested that the failure to take binary effects into account may have influenced the estimates of optical depth derived from microlensing surveys. The work we report on here is the first step in a systematic analysis of binary lenses and binary sources and their impact on the results of statistical microlensing surveys. In order to asses the problem, we ran Monte-Carlo simulations of various microlensing events involving binary stars (both as the source and as the lens). For each event with peak magnification > 1.34, we sampled the characteristic light curve and recorded the chi squared value when fitting the curve with a point lens model; we used this to asses the perturbation rate. We also recorded the parameters of each system, the maximum magnification, the times at which each light curve started and ended and the number of caustic crossings. We found that both the binarity of sources and the binarity of lenses increased the lensing rate. While the binarity of sources had a negligible effect on the perturbation rates of the light curves, the binarity of lenses had a notable effect. The combination of binary sources and binary lenses produces an observable rate of interesting events exhibiting multiple "repeats" in which the magnification rises above and dips below 1.34 several times. Finally, the binarity of lenses impacted both the durations of the events and the maximum magnifications. This work was supported in part by the SAO intern program (NSF grant AST-9731923) and NASA contracts NAS8-39073 and NAS8-38248 (CXC).

Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear.

PubMed

Behar-Cohen, Francine; Baillet, Gilles; de Ayguavives, Tito; Garcia, Paula Ortega; Krutmann, Jean; Peña-García, Pablo; Reme, Charlotte; Wolffsohn, James S

2014-01-01

Ultraviolet (UV) radiation potentially damages the skin, the immune system, and structures of the eye. A useful UV sun protection for the skin has been established. Since a remarkable body of evidence shows an association between UV radiation and damage to structures of the eye, eye protection is important, but a reliable and practical tool to assess and compare the UV-protective properties of lenses has been lacking. Among the general lay public, misconceptions on eye-sun protection have been identified. For example, sun protection is mainly ascribed to sunglasses, but less so to clear lenses. Skin malignancies in the periorbital region are frequent, but usual topical skin protection does not include the lids. Recent research utilized exact dosimetry and demonstrated relevant differences in UV burden to the eye and skin at a given ambient irradiation. Chronic UV effects on the cornea and lens are cumulative, so effective UV protection of the eyes is important for all age groups and should be used systematically. Protection of children's eyes is especially important, because UV transmittance is higher at a very young age, allowing higher levels of UV radiation to reach the crystalline lens and even the retina. Sunglasses as well as clear lenses (plano and prescription) effectively reduce transmittance of UV radiation. However, an important share of the UV burden to the eye is explained by back reflection of radiation from lenses to the eye. UV radiation incident from an angle of 135°-150° behind a lens wearer is reflected from the back side of lenses. The usual antireflective coatings considerably increase reflection of UV radiation. To provide reliable labeling of the protective potential of lenses, an eye-sun protection factor (E-SPF®) has been developed. It integrates UV transmission as well as UV reflectance of lenses. The E-SPF® compares well with established skin-sun protection factors and provides clear messages to eye health care providers and to lay consumers.

CLASH: Extending galaxy strong lensing to small physical scales with distant sources highly magnified by galaxy cluster members

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grillo, C.; Christensen, L.; Gobat, R.

2014-05-01

We present a complex strong lensing system in which a double source is imaged five times by two early-type galaxies. We take advantage in this target of the extraordinary multi-band photometric data set obtained as part of the Cluster Lensing And Supernova survey with Hubble (CLASH) program, complemented by the spectroscopic measurements of the VLT/VIMOS and FORS2 follow-up campaign. We use a photometric redshift value of 3.7 for the source and confirm spectroscopically the membership of the two lenses to the galaxy cluster MACS J1206.2–0847 at redshift 0.44. We exploit the excellent angular resolution of the HST/ACS images to modelmore » the two lenses in terms of singular isothermal sphere profiles and derive robust effective velocity dispersion values of 97 ± 3 and 240 ± 6 km s{sup –1}. Interestingly, the total mass distribution of the cluster is also well characterized by using only the local information contained in this lensing system, which is located at a projected distance of more than 300 kpc from the cluster luminosity center. According to our best-fitting lensing and composite stellar population models, the source is magnified by a total factor of 50 and has a luminous mass of approximately (1.0 ± 0.5) × 10{sup 9} M {sub ☉} (assuming a Salpeter stellar initial mass function). By combining the total and luminous mass estimates of the two lenses, we measure luminous over total mass fractions projected within the effective radii of 0.51 ± 0.21 and 0.80 ± 0.32. Remarkably, with these lenses we can extend the analysis of the mass properties of lens early-type galaxies by factors that are approximately two and three times smaller than previously done with regard to, respectively, velocity dispersion and luminous mass. The comparison of the total and luminous quantities of our lenses with those of astrophysical objects with different physical scales, like massive early-type galaxies and dwarf spheroidals, reveals the potential of studies of this kind for improving our knowledge about the internal structure of galaxies. These studies, made possible thanks to the CLASH survey, will allow us to go beyond the current limits posed by the available lens samples in the field.« less

Probing dark energy with lensing magnification in photometric surveys.

PubMed

Schneider, Michael D

2014-02-14

I present an estimator for the angular cross correlation of two tracers of the cosmological large-scale structure that utilizes redshift information to isolate separate physical contributions. The estimator is derived by solving the Limber equation for a reweighting of the foreground tracer that nulls either clustering or lensing contributions to the cross correlation function. Applied to future photometric surveys, the estimator can enhance the measurement of gravitational lensing magnification effects to provide a competitive independent constraint on the dark energy equation of state.

To the horizon and beyond: Weak lensing of the CMB and binary inspirals into horizonless objects

NASA Astrophysics Data System (ADS)

Kesden, Michael

This thesis examines two predictions of general relativity: weak lensing and gravitational waves. The cosmic microwave background (CMB) is gravitationally lensed by the large-scale structure between the observer and the last- scattering surface. This weak lensing induces non-Gaussian correlations that can be used to construct estimators for the deflection field. The error and bias of these estimators are derived and used to analyze the viability of lensing reconstruction for future CMB experiments. Weak lensing also affects the one-point probability distribution function of the CMB. The skewness and kurtosis induced by lensing and the Sunayev- Zel'dovich (SZ) effect are calculated as functions of the angular smoothing scale of the map. While these functions offer the advantage of easy computability, only the skewness from lensing-SZ correlations can potentially be detected, even in the limit of the largest amplitude fluctuations allowed by observation. Lensing estimators are also essential to constrain inflation, the favored explanation for large-scale isotropy and the origin of primordial perturbations. B-mode polarization is considered to be a "smoking-gun" signature of inflation, and lensing estimators can be used to recover primordial B-modes from lensing-induced contamination. The ability of future CMB experiments to constrain inflation is assessed as functions of survey size and instrumental sensitivity. A final application of lensing estimators is to constrain a possible cutoff in primordial density perturbations on near-horizon scales. The paucity of independent modes on such scales limits the statistical certainty of such a constraint. Measurements of the deflection field can be used to constrain at the 3s level the existence of a cutoff large enough to account for current CMB observations. A final chapter of this thesis considers an independent topic: the gravitational-wave (GW) signature of a binary inspiral into a horizonless object. If the supermassive objects at galactic centers lack the horizons of traditional black holes, inspiraling objects could emit GWs after passing within their surfaces. The GWs produced by such an inspiral are calculated, revealing distinctive features potentially observable by future GW observatories.

Photometric redshift requirements for lens galaxies in galaxy-galaxy lensing analyses

NASA Astrophysics Data System (ADS)

Nakajima, R.; Mandelbaum, R.; Seljak, U.; Cohn, J. D.; Reyes, R.; Cool, R.

2012-03-01

Weak gravitational lensing is a valuable probe of galaxy formation and cosmology. Here we quantify the effects of using photometric redshifts (photo-z) in galaxy-galaxy lensing, for both sources and lenses, both for the immediate goal of using galaxies with photo-z as lenses in the Sloan Digital Sky Survey (SDSS) and as a demonstration of methodology for large, upcoming weak lensing surveys that will by necessity be dominated by lens samples with photo-z. We calculate the bias in the lensing mass calibration as well as consequences for absolute magnitude (i.e. k-corrections) and stellar mass estimates for a large sample of SDSS Data Release 8 (DR8) galaxies. The redshifts are obtained with the template-based photo-z code ZEBRA on the SDSS DR8 ugriz photometry. We assemble and characterize the calibration samples (˜9000 spectroscopic redshifts from four surveys) to obtain photometric redshift errors and lensing biases corresponding to our full SDSS DR8 lens and source catalogues. Our tests of the calibration sample also highlight the impact of observing conditions in the imaging survey when the spectroscopic calibration covers a small fraction of its footprint; atypical imaging conditions in calibration fields can lead to incorrect conclusions regarding the photo-z of the full survey. For the SDSS DR8 catalogue, we find σΔz/(1+z)= 0.096 and 0.113 for the lens and source catalogues, with flux limits of r= 21 and 21.8, respectively. The photo-z bias and scatter is a function of photo-z and template types, which we exploit to apply photo-z quality cuts. By using photo-z rather than spectroscopy for lenses, dim blue galaxies and L* galaxies up to z˜ 0.4 can be used as lenses, thus expanding into unexplored areas of parameter space. We also explore the systematic uncertainty in the lensing signal calibration when using source photo-z, and both lens and source photo-z; given the size of existing training samples, we can constrain the lensing signal calibration (and therefore the normalization of the surface mass density) to within 2 and 4 per cent, respectively.

Power Profiles and In Vitro Optical Quality of Scleral Contact Lenses: Effect of the Aperture and Power.

PubMed

Domínguez-Vicent, Alberto; Esteve-Taboada, Jose Juan; Recchioni, Alberto; Brautaset, Rune

2018-05-01

To assess the power profile and in vitro optical quality of scleral contact lenses with different powers as a function of the optical aperture. The mini and semiscleral contact lenses (Procornea) were measured for five powers per design. The NIMO TR-1504 (Lambda-X) was used to assess the power profile and Zernike coefficients of each contact lens. Ten measurements per lens were taken at 3- and 6-mm apertures. Furthermore, the optical quality of each lens was described in Zernike coefficients, modulation transfer function, and point spread function (PSF). A convolution of each lens PSF with an eye-chart image was also computed. The optical power fluctuated less than 0.5 diopters (D) along the optical zone of each lens. However, the optical power obtained for some lenses did not match with its corresponding nominal one, the maximum difference being 0.5 D. In optical quality, small differences were obtained among all lenses within the same design. Although significant differences were obtained among lenses (P<0.05), these showed small impact in the image quality of each convolution. Insignificant power fluctuations were obtained along the optical zone measured for each scleral lens. Additionally, the optical quality of both lenses has showed to be independent of the lens power within the same aperture.

Estimating the weak-lensing rotation signal in radio cosmic shear surveys

NASA Astrophysics Data System (ADS)

Thomas, Daniel B.; Whittaker, Lee; Camera, Stefano; Brown, Michael L.

2017-09-01

Weak lensing has become an increasingly important tool in cosmology and the use of galaxy shapes to measure cosmic shear has become routine. The weak-lensing distortion tensor contains two other effects in addition to the two components of shear: the convergence and rotation. The rotation mode is not measurable using the standard cosmic shear estimators based on galaxy shapes, as there is no information on the original shapes of the images before they were lensed. Due to this, no estimator has been proposed for the rotation mode in cosmological weak-lensing surveys, and the rotation mode has never been constrained. Here, we derive an estimator for this quantity, which is based on the use of radio polarization measurements of the intrinsic position angles of galaxies. The rotation mode can be sourced by physics beyond Λ cold dark matter (ΛCDM), and also offers the chance to perform consistency checks of ΛCDM and of weak-lensing surveys themselves. We present simulations of this estimator and show that, for the pedagogical example of cosmic string spectra, this estimator could detect a signal that is consistent with the constraints from Planck. We examine the connection between the rotation mode and the shear B modes and thus how this estimator could help control systematics in future radio weak-lensing surveys.

65. VIEW LOOKING UPSTREAM FROM FLUME SUBSTRUCTURE, SHOWING COLUMBIA IMPROVEMENT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

65. VIEW LOOKING UPSTREAM FROM FLUME SUBSTRUCTURE, SHOWING COLUMBIA IMPROVEMENT COMPANY'S NEISSON CREEK SAWMILL. Print No. 177, November 1903 - Electron Hydroelectric Project, Along Puyallup River, Electron, Pierce County, WA

Cross-correlation of gravitational lensing from DES Science Verification data with SPT and Planck lensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirk, D.; Omori, Y.; Benoit-Lévy, A.

We measure the cross-correlation between weak lensing of galaxy images and of the cosmic microwave background (CMB). The effects of gravitational lensing on different sources will be correlated if the lensing is caused by the same mass fluctuations. We use galaxy shape measurements from 139 degmore » $$^{2}$$ of the Dark Energy Survey (DES) Science Verification data and overlapping CMB lensing from the South Pole Telescope (SPT) and Planck. The DES source galaxies have a median redshift of $$z_{\\rm med} {\\sim} 0.7$$, while the CMB lensing kernel is broad and peaks at $$z{\\sim}2$$. The resulting cross-correlation is maximally sensitive to mass fluctuations at $$z{\\sim}0.44$$. Assuming the Planck 2015 best-fit cosmology, the amplitude of the DES$$\\times$$SPT cross-power is found to be $$A = 0.88 \\pm 0.30$$ and that from DES$$\\times$$Planck to be $$A = 0.86 \\pm 0.39$$, where $A=1$ corresponds to the theoretical prediction. These are consistent with the expected signal and correspond to significances of $$2.9 \\sigma$$ and $$2.2 \\sigma$$ respectively. We demonstrate that our results are robust to a number of important systematic effects including the shear measurement method, estimator choice, photometric redshift uncertainty and CMB lensing systematics. Significant intrinsic alignment of galaxy shapes would increase the cross-correlation signal inferred from the data; we calculate a value of $$A = 1.08 \\pm 0.36$$ for DES$$\\times$$SPT when we correct the observations with a simple IA model. With three measurements of this cross-correlation now existing in the literature, there is not yet reliable evidence for any deviation from the expected LCDM level of cross-correlation, given the size of the statistical uncertainties and the significant impact of systematic errors, particularly IAs. We provide forecasts for the expected signal-to-noise of the combination of the five-year DES survey and SPT-3G.« less

Modelling cortical cataractogenesis 22: is in vitro reduction of damage in model diabetic rat cataract by taurine due to its antioxidant activity?

PubMed

Kilic, F; Bhardwaj, R; Caulfeild, J; Trevithick, J R

1999-09-01

The protective effect of taurine in model in vitro diabetic cataract and the mechanism of this effect were investigated in isolated rat lenses. Isolated rat lenses were incubated in medium 199 in elevated glucose (55.6 m m) with taurine (5 m m). Taurine concentrations in the lenses were determined by amino acid analysis. Accumulative leakage of the intracellular enzyme lactate dehydrogenase (LDH) was used to estimate damage to the lens, as previously reported. In the clear lenses, prior to vacuole formation, after 1 or 2 days of incubation, the taurine and amino acids in lenses decreased progressively in concentration. In lenses incubated with 5 m m taurine, the level of taurine was increased towards that of control lenses. In taurine-treated lenses LDH leakage was significantly decreased, and lens clarity was maintained, similarly to that found previously for vitamin C and lipoic acid. To test whether taurine has similar antioxidant activity, we tested its ability to decrease luminol luminescence generated by (1) superoxide from hypoxanthine/xanthine oxidase and (2) peroxide from diluted glucose/glucose oxidase. For either superoxide or peroxide, the luminescence was decreased to zero, as a function of increasing taurine concentration, at 30 m m, approximately the physiological concentration of taurine in the lens. Spin trapping confirmed that taurine scavenged superoxide. This is consistent with a role for taurine as an important antioxidant protecting the lens against oxidative insults. Amino acids also had antioxidant activity in this assay, and as a group, when all activities were summed, their loss also contributed significantly to the antioxidant loss. Taken in conjunction with Wolff and Crabbe's observation of increased free radical generation by glucose auto-oxidation in diabetes, this suggests a push-pull mechanism for increased oxidative stress in diabetic cataract, involving both increased free radicals and decreased radical scavenging antioxidants. Copyright 1999 Academic Press.

Improved bridge joint materials and design details.

DOT National Transportation Integrated Search

2017-06-01

Expansion joints accommodate bridge movements that result from factors such as thermal expansion and contraction, concrete shrinkage, creep effects, live loading, settlement of the foundation and substructure, and environmental stressors. Expansion j...

Peculiar velocity measurement in a clumpy universe

NASA Astrophysics Data System (ADS)

Habibi, Farhang; Baghram, Shant; Tavasoli, Saeed

Aims: In this work, we address the issue of peculiar velocity measurement in a perturbed Friedmann universe using the deviations from measured luminosity distances of standard candles from background FRW universe. We want to show and quantify the statement that in intermediate redshifts (0.5 < z < 2), deviations from the background FRW model are not uniquely governed by peculiar velocities. Luminosity distances are modified by gravitational lensing. We also want to indicate the importance of relativistic calculations for peculiar velocity measurement at all redshifts. Methods: For this task, we discuss the relativistic correction on luminosity distance and redshift measurement and show the contribution of each of the corrections as lensing term, peculiar velocity of the source and Sachs-Wolfe effect. Then, we use the SNe Ia sample of Union 2, to investigate the relativistic effects, we consider. Results: We show that, using the conventional peculiar velocity method, that ignores the lensing effect, will result in an overestimate of the measured peculiar velocities at intermediate redshifts. Here, we quantify this effect. We show that at low redshifts the lensing effect is negligible compare to the effect of peculiar velocity. From the observational point of view, we show that the uncertainties on luminosity of the present SNe Ia data prevent us from precise measuring the peculiar velocities even at low redshifts (z < 0.2).

20. Top 30/3. Plan of exposed substructure elevations. Wyoming ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Top 30/3. Plan of exposed substructure elevations. - Wyoming Valley Flood Control System, Woodward Pumping Station, East of Toby Creek crossing by Erie-Lackawanna Railroad, Edwardsville, Luzerne County, PA

Detail view of Fanno Creek trestle, showing trestle substructure, view ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view of Fanno Creek trestle, showing trestle substructure, view looking north - Oregon Electric Railroad, Fanno Creek Trestle, Garden Home to Wilsonville Segment, Milepost 34.7, Garden Home, Washington County, OR

In vitro power profiles of daily disposable contact lenses.

PubMed

Belda-Salmerón, Lurdes; Madrid-Costa, David; Ferrer-Blasco, Teresa; García-Lázaro, Santiago; Montés-Micó, Robert

2013-10-01

To evaluate and compare the distribution of refractive power within the optic zone of different soft contact lenses and to investigate the effect of lens decentration on the power profiles. The Nimo TR1504 instrument was used to measure the optical power across different aperture diameters (from 1.5mm to 5.5mm in steps of 0.5mm) of four daily disposable contact lenses: DAILIES TOTAL1, Proclear 1-Day, SofLens daily disposable and 1-DAY ACUVUE MOIST. Measurements were performed using a wet cell. Power data were evaluated when contact lenses were in its centered position and after inducing different amounts of lens decentration (from 0.2mm to 1.0mm in steps of 0.2mm). All contact lenses showed an increase - more negative - in lens power with distance from the lens center. The amount of change varied depending on the lens. It was about 10% of lens power for DAILIES TOTAL1 (-0.29diopters (D)), SofLens daily disposable (-0.36D), and Proclear 1-Day (-0.32D) whereas 1-DAY ACUVUE MOIST showed a percentage variation of 3.3% (-0.10D). After inducing a lens decentration up to 1mm, the power curves were shifted in the negative direction. However, the change obtained in lens power compared with well-centered position was always lower than a quarter of diopter both for all the lenses and aperture diameters. Our results showed a variation of the refractive power from the lens center, becoming more negative toward the periphery, with a negligible effect of the decentration for all disposable contact lenses studied. Copyright © 2013 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

Lens models and magnification maps of the six Hubble Frontier Fields clusters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Traci L.; Sharon, Keren; Bayliss, Matthew B.

2014-12-10

We present strong-lensing models as well as mass and magnification maps for the cores of the six Hubble Space Telescope (HST) Frontier Fields galaxy clusters. Our parametric lens models are constrained by the locations and redshifts of multiple image systems of lensed background galaxies. We use a combination of photometric redshifts and spectroscopic redshifts of the lensed background sources obtained by us (for A2744 and AS1063), collected from the literature, or kindly provided by the lensing community. Using our results, we (1) compare the derived mass distribution of each cluster to its light distribution, (2) quantify the cumulative magnification powermore » of the HST Frontier Fields clusters, (3) describe how our models can be used to estimate the magnification and image multiplicity of lensed background sources at all redshifts and at any position within the cluster cores, and (4) discuss systematic effects and caveats resulting from our modeling methods. We specifically investigate the effect of the use of spectroscopic and photometric redshift constraints on the uncertainties of the resulting models. We find that the photometric redshift estimates of lensed galaxies are generally in excellent agreement with spectroscopic redshifts, where available. However, the flexibility associated with relaxed redshift priors may cause the complexity of large-scale structure that is needed to account for the lensing signal to be underestimated. Our findings thus underline the importance of spectroscopic arc redshifts, or tight photometric redshift constraints, for high precision lens models. All products from our best-fit lens models (magnification, convergence, shear, deflection field) and model simulations for estimating errors are made available via the Mikulski Archive for Space Telescopes.« less

Visual performance of four simultaneous-image multifocal contact lenses under dim and glare conditions.

PubMed

García-Lázaro, Santiago; Ferrer-Blasco, Teresa; Madrid-Costa, David; Albarrán-Diego, César; Montés-Micó, Robert

2015-01-01

To assess and compare the effects of four simultaneous-image multifocal contact lenses (SIMCLs), and those with distant-vision-only contact lenses on visual performance in early presbyopes, under dim conditions, including the effects of induced glare. In this double-masked crossover study design, 28 presbyopic subjects aged 40 to 46 years were included. All participants were fitted with the four different SIMCLs (Air Optix Aqua Multifocal [AOAM; Alcon], PureVision Multifocal [PM; Bausch & Lomb], Acuvue Oasys for Presbyopia [AOP; Johnson & Johnson Vision], and Biofinity Multifocal [BM; CooperVision]) and with monofocal contact lenses (Air Optix Aqua, Alcon). After 1 month of daily contact lens wearing, each subject's binocular distance visual acuity (BDVA) and binocular distance contrast sensitivity (BDCS) were measured using the Functional Visual Analyzer (Stereo Optical Co., Inc.) under mesopic conditions (3 candela [cd]/m) both with no glare and under the 2 levels of induced glare: 1.0 lux (glare 1) and 28 lux (glare 2). Among the SIMCLs, in terms of BDVA, AOAM and PM outperformed BM and AOP. All contact lenses performed better at level without glare, followed by Glare 1, and with the worst results obtained under glare 2. Binocular distance contrast sensitivity revealed statistically significant differences for 12 cycles per degree (cpd). Among the SIMCLs, post hoc multiple comparison testing revealed that AOAM and PM provided the best BDCS at the three luminance levels. In both cases, BDVA and BDCS at 12 cpd, monofocal contact lenses outperformed all SIMCL ones at all lighting conditions. Air Optix Aqua Multifocal and PM provided better visual performance than BM and AOP for distance vision with low addition and under dim conditions, but they all provide worse performance than monofocal contact lenses.

Discovery of Finely Structured Dynamic Solar Corona Observed in the Hi-C Telescope

NASA Technical Reports Server (NTRS)

Winebarger, A.; Cirtain, J.; Golub, L.; DeLuca, E.; Savage, S.; Alexander, C.; Schuler, T.

2014-01-01

In the summer of 2012, the High-resolution Coronal Imager (Hi-C) flew aboard a NASA sounding rocket and collected the highest spatial resolution images ever obtained of the solar corona. One of the goals of the Hi-C flight was to characterize the substructure of the solar corona. We therefore examine how the intensity scales from AIA resolution to Hi-C resolution. For each low-resolution pixel, we calculate the standard deviation in the contributing high-resolution pixel intensities and compare that to the expected standard deviation calculated from the noise. If these numbers are approximately equal, the corona can be assumed to be smoothly varying, i.e. have no evidence of substructure in the Hi-C image to within Hi-C's ability to measure it given its throughput and readout noise. A standard deviation much larger than the noise value indicates the presence of substructure. We calculate these values for each low-resolution pixel for each frame of the Hi-C data. On average, 70 percent of the pixels in each Hi-C image show no evidence of substructure. The locations where substructure is prevalent is in the moss regions and in regions of sheared magnetic field. We also find that the level of substructure varies significantly over the roughly 160 s of the Hi-C data analyzed here. This result indicates that the finely structured corona is concentrated in regions of heating and is highly time dependent.

DISCOVERY OF FINELY STRUCTURED DYNAMIC SOLAR CORONA OBSERVED IN THE Hi-C TELESCOPE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winebarger, Amy R.; Cirtain, Jonathan; Savage, Sabrina

In the Summer of 2012, the High-resolution Coronal Imager (Hi-C) flew on board a NASA sounding rocket and collected the highest spatial resolution images ever obtained of the solar corona. One of the goals of the Hi-C flight was to characterize the substructure of the solar corona. We therefore examine how the intensity scales from AIA resolution to Hi-C resolution. For each low-resolution pixel, we calculate the standard deviation in the contributing high-resolution pixel intensities and compare that to the expected standard deviation calculated from the noise. If these numbers are approximately equal, the corona can be assumed to bemore » smoothly varying, i.e., have no evidence of substructure in the Hi-C image to within Hi-C's ability to measure it given its throughput and readout noise. A standard deviation much larger than the noise value indicates the presence of substructure. We calculate these values for each low-resolution pixel for each frame of the Hi-C data. On average, 70% of the pixels in each Hi-C image show no evidence of substructure. The locations where substructure is prevalent is in the moss regions and in regions of sheared magnetic field. We also find that the level of substructure varies significantly over the roughly 160 s of the Hi-C data analyzed here. This result indicates that the finely structured corona is concentrated in regions of heating and is highly time dependent.« less

In vitro study of antibiotic effect on bacterial adherence to acrylic intraocular lenses.

PubMed

Gaál, Valéria; Kilár, Ferenc; Acs, Barnabás; Szijjártó, Zsuzsanna; Kocsis, Béla; Kustos, Ildikó

2005-11-10

Implantation of artificial intraocular lenses into the eye during ophthalmic surgical procedures ensures an unliving surface on which bacterial pathogens may attach and form biofilms. Despite antibiotic treatment bacteria growing in biofilms might cause inflammation and serious complications. In this study the adhesive ability of 7 Staphylococcus aureus and 11 coagulase-negative Staphylococcus (CNS) strains to the surface of acrylic intraocular lenses had been examined by the ultrasonic method. In untreated cases adhesion of the S. aureus and CNS strains did not differ significantly. We could not demonstrate significant differences between the adhesive ability of the standard strains and the clinical isolates. In this study a single--60 min long--antibiotic (ciprofloxacin and tobramycin) treatment had been applied, that correlate well with the single or intermittant antibiotic prophylaxis of patients. Ciprofloxacin administration was able to reduce significantly the number of attached cells on the surface of acrylic lenses both in the case of S. aureus and CNS strains. Dependence of the effect from concentration could also be demonstrated. Tobramycin treatment was able to inhibit significantly the attachment of S. aureus cells. Despite the debate on antibiotic prophylaxis we presented in our experiments that a single antibiotic administration can decrease the attachment of bacterial cells to the surface of acrylic intraocular lenses, and might be effective in the prevention of postoperative endophthalmitis, that is a rare but serious complication of ophthalmic surgery.

Noise estimates for measurements of weak lensing from the Ly α forest

NASA Astrophysics Data System (ADS)

Metcalf, R. Benton; Croft, Rupert A. C.; Romeo, Alessandro

2018-06-01

Lensing changes the apparent separation between pixels in the Ly α forest of separate quasars or high-redshift objects by changing their observed positions on the sky. This changes the implied correlations in the absorption and in particular makes the Ly α forest correlation function, or power spectrum, locally anisotropic in the plane of the sky. We have proposed a method for measuring weak lensing using this effect. Here, we estimate the noise expected in weak lensing maps and power spectra for different sets of observational parameters. We find that surveys of the size and quality of the ones being done today and ones planned for the future will be able to measure the lensing power spectrum at a source redshift of z ≃ 2.5 with high precision and even be able to image the distribution of foreground matter with high fidelity on degree scales. For example, we predict that Ly α forest lensing measurements from the DESI and WEAVE surveys should yield the mass fluctuation amplitude with a statistical error of ˜3 per cent, eBOSS ˜6 per cent. and the proposed MSE survey less than 1 per cent. By dividing the redshift range into multiple bins, some tomographic lensing information should be accessible as well. This would allow for cosmological lensing measurements at higher redshift than are accessible with galaxy shear surveys and correspondingly better constraints on the evolution of dark energy at relatively early times.

Gravitational Lenses and the Structure and Evolution of Galaxies

NASA Technical Reports Server (NTRS)

Kochanek, Christopher

2003-01-01

The grant has supported the completion of 16 papers and 4 conference proceedings to date. During the first year of the project we completed five papers, each of which represents a new direction in the theory and interpretation of gravitational lenses. In the first paper, "The Importance of Einstein Rings", we developed the first theory for the formation and structure of the Einstein rings formed by lensing extended sources like the host galaxies of quasar and radio sources. We applied the theory to three lenses with lensed host galaxies. For the time delay lens PG 1115+080 we found that the structure of the Einstein ring ruled out models of the gravitational potential which permitted a large Hubble constant (70 km/s Mpc). In the second paper, :Cusped Mass Models Of Gravitational Lenses", we introduced a new class of lens models where the central density is characterized by a cusp ( rho proportional to tau(sup -gamma), 1 less than gamma less than 2) as in most modern models and theories of galaxies rather than a finite core radius. In the third paper, "Global Probes of the Impact of Baryons on Dark Matter Halos", we made the first globally consistent models for the separation distribution of gravitational lenses including both galaxy and cluster lenses. We show that the key physics for the origin of the sharp separation cutoff in the separation distribution near 3 arc sec is the effect of the cooling baryons in galaxies on the density structure of the system.

Fatigue reassessment for lifetime extension of offshore wind monopile substructures

NASA Astrophysics Data System (ADS)

Ziegler, Lisa; Muskulus, Michael

2016-09-01

Fatigue reassessment is required to decide about lifetime extension of aging offshore wind farms. This paper presents a methodology to identify important parameters to monitor during the operational phase of offshore wind turbines. An elementary effects method is applied to analyze the global sensitivity of residual fatigue lifetimes to environmental, structural and operational parameters. Therefore, renewed lifetime simulations are performed for a case study which consists of a 5 MW turbine with monopile substructure in 20 m water depth. Results show that corrosion, turbine availability, and turbulence intensity are the most influential parameters. This can vary strongly for other settings (water depth, turbine size, etc.) making case-specific assessments necessary.

Realizing high-performance metamaterial absorber based on the localized surface plasmon resonance in the terahertz regime

NASA Astrophysics Data System (ADS)

Yunfeng, Lin; Xiaoqi, Hu; Lin, Hu

2018-04-01

A composite structure design metamaterial absorber is designed and simulated. The proposed composite structure consists of a double-hole sub-structure and a double-metallic particle sub-structure. The damping constant of bulk gold layer is optimized to eliminate the adverse effects of the grain boundary and the surface scattering of thin films on the absorption property. Two absorption peaks (A1 = 58%, A2 = 23%) are achieved based on the localized surface plasmon (LSP) modes resonance. Moreover, the plasmonic hybridization phenomenon between LSP modes is found, which leads to the absorption enhancement between two absorption peaks. The proposed metamaterial absorber holds the property of wide-angle incidence.

Effect of manufacturing defects on optical performance of discontinuous freeform lenses.

PubMed

Wang, Kai; Liu, Sheng; Chen, Fei; Liu, Zongyuan; Luo, Xiaobing

2009-03-30

Discontinuous freeform lens based secondary optics are essential to LED illumination systems. Surface roughness and smooth transition between two discrete sub-surfaces are two of the most common manufacturing defects existing in discontinuous freeform lenses. The effects of these two manufacturing defects on the optical performance of two discontinuous freeform lenses were investigated by comparing the experimental results with the numerical simulation results based on Monte Carlo ray trace method. The results demonstrated that manufacturing defects induced surface roughness had small effect on the light output efficiency and the shape of light pattern of the PMMA lens but significantly affected the uniformity of light pattern, which declined from 0.644 to 0.313. The smooth transition surfaces with deviation angle more than 60 degrees existing in the BK7 glass lens, not only reduced the uniformity of light pattern, but also reduced the light output efficiency from 96.9% to 91.0% and heavily deformed the shape of the light pattern. Comparing with the surface roughness, the smooth transition surface had a much more adverse effect on the optical performance of discontinuous freeform lenses. Three methods were suggested to improve the illumination performance according to the analysis and discussion.

Gravitational microlensing - The effect of random motion of individual stars in the lensing galaxy

NASA Technical Reports Server (NTRS)

Kundic, Tomislav; Wambsganss, Joachim

1993-01-01

We investigate the influence of random motion of individual stars in the lensing galaxy on the light curve of a gravitationally lensed background quasar. We compare this with the effects of the transverse motion of the galaxy. We find that three-dimensional random motion of stars with a velocity dispersion sigma in each dimension is more effective in producing 'peaks' in a microlensed light curve by a factor a about 1.3 than motion of the galaxy with a transverse velocity v(t) = sigma. This effectiveness parameter a seems to depend only weakly on the surface mass density. With an assumed transverse velocity of v(t) = 600 km/s of the galaxy lensing the QSO 2237+0305 and a measured velocity dispersion of sigma = 215 km/s, the expected rate of maxima in the light curves calculated for bulk motion alone has to be increased by about 10 percent due to the random motion of stars. As a consequence, the average time interval Delta t between two high-magnification events is smaller than the time interval Delta(t) bulk, calculated for bulk motion alone, Delta t about 0.9 Delta(t) bulk.

The infrared imaging spectrograph (IRIS) for TMT: overview of innovative science programs

NASA Astrophysics Data System (ADS)

Wright, Shelley A.; Larkin, James E.; Moore, Anna M.; Do, Tuan; Simard, Luc; Adamkovics, Maté; Armus, Lee; Barth, Aaron J.; Barton, Elizabeth; Boyce, Hope; Cooke, Jeffrey; Cote, Patrick; Davidge, Timothy; Ellerbroek, Brent; Ghez, Andrea M.; Liu, Michael C.; Lu, Jessica R.; Macintosh, Bruce A.; Mao, Shude; Marois, Christian; Schoeck, Matthias; Suzuki, Ryuji; Tan, Jonathan C.; Treu, Tommaso; Wang, Lianqi; Weiss, Jason

2014-07-01

IRIS (InfraRed Imaging Spectrograph) is a first light near-infrared diffraction limited imager and integral field spectrograph being designed for the future Thirty Meter Telescope (TMT). IRIS is optimized to perform astronomical studies across a significant fraction of cosmic time, from our Solar System to distant newly formed galaxies (Barton et al. [1]). We present a selection of the innovative science cases that are unique to IRIS in the era of upcoming space and ground-based telescopes. We focus on integral field spectroscopy of directly imaged exoplanet atmospheres, probing fundamental physics in the Galactic Center, measuring 104 to 1010 M supermassive black hole masses, resolved spectroscopy of young star-forming galaxies (1 < z < 5) and first light galaxies (6 < z < 12), and resolved spectroscopy of strong gravitational lensed sources to measure dark matter substructure. For each of these science cases we use the IRIS simulator (Wright et al. [2], Do et al. [3]) to explore IRIS capabilities. To highlight the unique IRIS capabilities, we also update the point and resolved source sensitivities for the integral field spectrograph (IFS) in all five broadband filters (Z, Y, J, H, K) for the finest spatial scale of 0.004" per spaxel. We briefly discuss future development plans for the data reduction pipeline and quicklook software for the IRIS instrument suite.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlberg, R. G.; Grillmair, C. J., E-mail: carlberg@astro.utoronto.ca, E-mail: carl@ipac.caltech.edu

Measurements of velocity and density perturbations along stellar streams in the Milky Way provide a time-integrated measure of dark matter substructure at larger galactic radius than the complementary instantaneous inner-halo strong lensing detection of dark matter sub-halos in distant galaxies. An interesting case to consider is the proposed Phoenix–Hermus star stream, which is long, thin, and on a nearly circular orbit, making it a particular good target to study for velocity variations along its length. In the presence of dark matter sub-halos, the stream velocities are significantly perturbed in a manner that is readily understood with the impulse approximation. Amore » set of simulations shows that only sub-halos above a few 10{sup 7} M {sub ⊙} lead to reasonably long-lived observationally detectable velocity variations of amplitude of order 1 km s{sup −1}, with an average of about one visible hit per (two-armed) stream over a 3 Gyr interval. An implication is that globular clusters themselves will not have a visible impact on the stream. Radial velocities have the benefit of being completely insensitive to distance errors. Distance errors scatter individual star velocities perpendicular and tangential to the mean orbit, but their mean values remain unbiased. Calculations like these help build the quantitative case to acquire large, fairly deep, precision velocity samples of stream stars.« less

Gravitational lensing in a cold dark matter universe

NASA Technical Reports Server (NTRS)

Narayan, Ramesh; White, Simon D. M.

1988-01-01

Gravitational lensing due to mass condensations in a biased cold dark matter (CDM) universe is investigated using the Press-Schechter (1974) theory with density fluctuation amplitudes taken from previous N-body work. Under the critical assumption that CDM haloes have small core radii, a distribution of image angular separations for high-z lensed quasars with a peak at about 1 arcsec and a half-width of a factor of about 10. Allowing for selection effects at small angular separations, this is in good agreement with the observed separations. The estimated frequency of lensing is somewhat lower than that observed, but the discrepancy can be removed by invoking amplification bias and by making a small upward adjustment to the density fluctuation amplitudes assumed in the CDM model.

The ellipticity of galaxy cluster haloes from satellite galaxies and weak lensing

DOE PAGES

Shin, Tae-hyeon; Clampitt, Joseph; Jain, Bhuvnesh; ...

2018-01-04

Here, we study the ellipticity of galaxy cluster haloes as characterized by the distribution of cluster galaxies and as measured with weak lensing. We use Monte Carlo simulations of elliptical cluster density profiles to estimate and correct for Poisson noise bias, edge bias and projection effects. We apply our methodology to 10 428 Sloan Digital Sky Survey clusters identified by the redMaPPer algorithm with richness above 20. We find a mean ellipticity =0.271 ± 0.002 (stat) ±0.031 (sys) corresponding to an axis ratio = 0.573 ± 0.002 (stat) ±0.039 (sys). We compare this ellipticity of the satellites to the halomore » shape, through a stacked lensing measurement using optimal estimators of the lensing quadrupole based on Clampitt and Jain (2016). We find a best-fitting axis ratio of 0.56 ± 0.09 (stat) ±0.03 (sys), consistent with the ellipticity of the satellite distribution. Thus, cluster galaxies trace the shape of the dark matter halo to within our estimated uncertainties. Finally, we restack the satellite and lensing ellipticity measurements along the major axis of the cluster central galaxy's light distribution. From the lensing measurements, we infer a misalignment angle with an root-mean-square of 30° ± 10° when stacking on the central galaxy. We discuss applications of halo shape measurements to test the effects of the baryonic gas and active galactic nucleus feedback, as well as dark matter and gravity. The major improvements in signal-to-noise ratio expected with the ongoing Dark Energy Survey and future surveys from Large Synoptic Survey Telescope, Euclid, and Wide Field Infrared Survey Telescope will make halo shapes a useful probe of these effects.« less

The ellipticity of galaxy cluster haloes from satellite galaxies and weak lensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shin, Tae-hyeon; Clampitt, Joseph; Jain, Bhuvnesh

Here, we study the ellipticity of galaxy cluster haloes as characterized by the distribution of cluster galaxies and as measured with weak lensing. We use Monte Carlo simulations of elliptical cluster density profiles to estimate and correct for Poisson noise bias, edge bias and projection effects. We apply our methodology to 10 428 Sloan Digital Sky Survey clusters identified by the redMaPPer algorithm with richness above 20. We find a mean ellipticity =0.271 ± 0.002 (stat) ±0.031 (sys) corresponding to an axis ratio = 0.573 ± 0.002 (stat) ±0.039 (sys). We compare this ellipticity of the satellites to the halomore » shape, through a stacked lensing measurement using optimal estimators of the lensing quadrupole based on Clampitt and Jain (2016). We find a best-fitting axis ratio of 0.56 ± 0.09 (stat) ±0.03 (sys), consistent with the ellipticity of the satellite distribution. Thus, cluster galaxies trace the shape of the dark matter halo to within our estimated uncertainties. Finally, we restack the satellite and lensing ellipticity measurements along the major axis of the cluster central galaxy's light distribution. From the lensing measurements, we infer a misalignment angle with an root-mean-square of 30° ± 10° when stacking on the central galaxy. We discuss applications of halo shape measurements to test the effects of the baryonic gas and active galactic nucleus feedback, as well as dark matter and gravity. The major improvements in signal-to-noise ratio expected with the ongoing Dark Energy Survey and future surveys from Large Synoptic Survey Telescope, Euclid, and Wide Field Infrared Survey Telescope will make halo shapes a useful probe of these effects.« less

The ellipticity of galaxy cluster haloes from satellite galaxies and weak lensing

NASA Astrophysics Data System (ADS)

Shin, Tae-hyeon; Clampitt, Joseph; Jain, Bhuvnesh; Bernstein, Gary; Neil, Andrew; Rozo, Eduardo; Rykoff, Eli

2018-04-01

We study the ellipticity of galaxy cluster haloes as characterized by the distribution of cluster galaxies and as measured with weak lensing. We use Monte Carlo simulations of elliptical cluster density profiles to estimate and correct for Poisson noise bias, edge bias and projection effects. We apply our methodology to 10 428 Sloan Digital Sky Survey clusters identified by the redMaPPer algorithm with richness above 20. We find a mean ellipticity =0.271 ± 0.002 (stat) ±0.031 (sys) corresponding to an axis ratio = 0.573 ± 0.002 (stat) ±0.039 (sys). We compare this ellipticity of the satellites to the halo shape, through a stacked lensing measurement using optimal estimators of the lensing quadrupole based on Clampitt and Jain (2016). We find a best-fitting axis ratio of 0.56 ± 0.09 (stat) ±0.03 (sys), consistent with the ellipticity of the satellite distribution. Thus, cluster galaxies trace the shape of the dark matter halo to within our estimated uncertainties. Finally, we restack the satellite and lensing ellipticity measurements along the major axis of the cluster central galaxy's light distribution. From the lensing measurements, we infer a misalignment angle with an root-mean-square of 30° ± 10° when stacking on the central galaxy. We discuss applications of halo shape measurements to test the effects of the baryonic gas and active galactic nucleus feedback, as well as dark matter and gravity. The major improvements in signal-to-noise ratio expected with the ongoing Dark Energy Survey and future surveys from Large Synoptic Survey Telescope, Euclid, and Wide Field Infrared Survey Telescope will make halo shapes a useful probe of these effects.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Munkejord, T.

This paper gives a summary of the Heidrun substructure including tethers and foundations. The focus will although be on the concrete substructure. The Heidrun Field is located in 345 m water depth in the northern part of the Haltenbanken area, approximately 100N miles from the west coast of mid-Norway. The field is developed by means of a concrete Tension Leg Platform (TLP) by Conoco Norway Inc. The TLP will be moored by 16 steel tethers, arranged in groups of four per corner, which secure the substructure (hull) to the concrete foundations. A general view of the TLP is shown. Themore » Heidrun TLP will be the northern most located platform in the North Sea when installed at Haltenbanken in 1995. Norwegian Contractors a.s (NC) is undertaking the Engineering, Procurement, Construction and Installation (EPCI) contract for the Heidrun TLP substructure. This comprises the complete delivery of the hull with two module support beams (MSB), including all mechanical outfitting. Furthermore, NC will perform all marine operations related to the substructure. For the concrete foundations NC has performed the detailed engineering work and has been responsible for the two to field and installation of the foundations.« less

Substructures in Clusters of Galaxies

NASA Astrophysics Data System (ADS)

Lehodey, Brigitte Tome

2000-01-01

This dissertation presents two methods for the detection of substructures in clusters of galaxies and the results of their application to a group of four clusters. In chapters 2 and 3, we remember the main properties of clusters of galaxies and give the definition of substructures. We also try to show why the study of substructures in clusters of galaxies is so important for Cosmology. Chapters 4 and 5 describe these two methods, the first one, the adaptive Kernel, is applied to the study of the spatial and kinematical distribution of the cluster galaxies. The second one, the MVM (Multiscale Vision Model), is applied to analyse the cluster diffuse X-ray emission, i.e., the intracluster gas distribution. At the end of these two chapters, we also present the results of the application of these methods to our sample of clusters. In chapter 6, we draw the conclusions from the comparison of the results we obtain with each method. In the last chapter, we present the main conclusions of this work trying to point out possible developments. We close with two appendices in which we detail some questions raised in this work not directly linked to the problem of substructures detection.

DASS: efficient discovery and p-value calculation of substructures in unordered data.

PubMed

Hollunder, Jens; Friedel, Maik; Beyer, Andreas; Workman, Christopher T; Wilhelm, Thomas

2007-01-01

Pattern identification in biological sequence data is one of the main objectives of bioinformatics research. However, few methods are available for detecting patterns (substructures) in unordered datasets. Data mining algorithms mainly developed outside the realm of bioinformatics have been adapted for that purpose, but typically do not determine the statistical significance of the identified patterns. Moreover, these algorithms do not exploit the often modular structure of biological data. We present the algorithm DASS (Discovery of All Significant Substructures) that first identifies all substructures in unordered data (DASS(Sub)) in a manner that is especially efficient for modular data. In addition, DASS calculates the statistical significance of the identified substructures, for sets with at most one element of each type (DASS(P(set))), or for sets with multiple occurrence of elements (DASS(P(mset))). The power and versatility of DASS is demonstrated by four examples: combinations of protein domains in multi-domain proteins, combinations of proteins in protein complexes (protein subcomplexes), combinations of transcription factor target sites in promoter regions and evolutionarily conserved protein interaction subnetworks. The program code and additional data are available at http://www.fli-leibniz.de/tsb/DASS

The impact of baryonic matter on gravitational lensing by galaxy clusters

NASA Astrophysics Data System (ADS)

Lee, Brandyn E.; King, Lindsay; Applegate, Douglas; McCarthy, Ian

2017-01-01

Since the bulk of the matter comprising galaxy clusters exists in the form of dark matter, gravitational N-body simulations have historically been an effective way to investigate large scale structure formation and the astrophysics of galaxy clusters. However, upcoming telescopes such as the Large Synoptic Survey Telescope are expected to have lower systematic errors than older generations, reducing measurement uncertainties and requiring that astrophysicists better quantify the impact of baryonic matter on the cluster lensing signal. Here we outline the effects of baryonic processes on cluster density profiles and on weak lensing mass and concentration estimates. Our analysis is done using clusters grown in the suite of cosmological hydrodynamical simulations known as cosmo-OWLS.

Effect of internal lubricating agents of disposable soft contact lenses on higher-order aberrations after blinking.

PubMed

Koh, Shizuka; Maeda, Naoyuki; Hamano, Takashi; Hirohara, Yoko; Mihashi, Toshifumi; Hori, Yuichi; Hosohata, Jun; Fujikado, Takashi; Tano, Yasuo

2008-03-01

To investigate whether the polymer composition of disposable soft contact lenses affects sequential changes in higher-order aberrations (HOAs). Fifteen subjects who wore disposable soft contact lenses with dryness-related symptoms and 15 non-contact lens wearers were enrolled in this study. Ocular HOAs were measured for 60 seconds in each subject wearing a disposable etafilcon A lens (conventional lens) or a disposable etafilcon A lens with polyvinyl pyrrolidone (PVP) (lens with PVP) after 1 hour of contact lens wear. During the measurement, subjects were forced to blink every 10 seconds. The aberration data were analyzed in the central 4-mm diameter up to the sixth-order Zernike polynomials. Total HOAs, the fluctuation index (FI), and the stability index (SI) of the total HOAs over time were compared between the two groups. The subjective ocular dryness also was scored. In symptomatic wearers of disposable soft contact lenses, the total HOAs, the FI, and the SI with the lens with PVP were significantly (P=0.013, P=0.014, P=0.019, respectively) lower than with the conventional lens, whereas a significant (P=0.018) difference between the two lenses was observed only in the FI in non-contact lens wearers. Subjective ocular dryness with the lens with PVP significantly decreased compared with the conventional lens in both groups. Sequential measurement of HOAs may be a useful objective method to evaluate the effect of internal lubricating agents of disposable soft contact lenses on optical quality.

Visualizing hydrophobic domains in silicone hydrogel lenses with Sudan IV.

PubMed

Jacob, Jean T; Levet, Jacques; Edwards, Tamika A; Dassanayake, Nissanke; Ketelson, Howard

2012-06-08

A lipophilic dye is used to investigate the degree to which the surface and bulk hydrophobic domains of the lenses can be imaged and to identify specific changes in the availability of those domains after in vitro wear and cleaning conditions. The effect of a multipurpose solution (MPS), OPTI-FREE RepleniSH, on lens hydrophobic domains was also investigated. Hydrophobic domains were determined using a saturated solution of Sudan IV. Staining periods of 30 minutes and 16 hours were used to determine surface versus bulk hydrophobic domains. Four types of silicone hydrogel lens materials were tested. The degree of staining was visually documented by photography and quantitatively determined by extraction and analysis of the total amount of dye adsorbed. Specific differences in staining were found for all control lenses. Exposure to in vitro wear conditions significantly decreased the staining response for all lens types as compared with unworn lenses (P = 0.001). However, the trend of staining remained the same: balafilcon A > galyfilcon A > senofilcon A > lotrafilcon B. MPS decreased the extent of staining; the degree of its effect varied with lens type. Hydrophobic staining with Sudan IV visualized domains on and within silicone hydrogel lenses. Differences in staining response after exposure to wear and cleaning conditions indicate the potential for protein and lipid deposition on the different lens types and the ability of MPS to affect that deposition. Hydrophobic staining may be useful for determining differences in surface modification and lipophilicity of silicone hydrogel lenses.

Planck intermediate results: XLI. A map of lensing-induced B-modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ade, P. A. R.; Aghanim, N.; Ashdown, M.

The secondary cosmic microwave background (CMB) B-modes stem from the post-decoupling distortion of the polarization E-modes due to the gravitational lensing effect of large-scale structures. These lensing-induced B-modes constitute both a valuable probe of the dark matter distribution and an important contaminant for the extraction of the primary CMB B-modes from inflation. Planck provides accurate nearly all-sky measurements of both the polarization E-modes and the integrated mass distribution via the reconstruction of the CMB lensing potential. By combining these two data products, we have produced in this paper an all-sky template map of the lensing-induced B-modes using a real-space algorithmmore » that minimizes the impact of sky masks. The cross-correlation of this template with an observed (primordial and secondary) B-mode map can be used to measure the lensing B-mode power spectrum at multipoles up to 2000. In particular, when cross-correlating with the B-mode contribution directly derived from the Planck polarization maps, we obtain lensing-induced B-mode power spectrum measurement at a significance level of 12σ, which agrees with the theoretical expectation derived from the Planck best-fit Λ cold dark matter model. This unique nearly all-sky secondary B-mode template, which includes the lensing-induced information from intermediate to small (10 ≲ ℓ ≲ 1000) angular scales, is delivered as part of the Planck 2015 public data release. Finally, it will be particularly useful for experiments searching for primordial B-modes, such as BICEP2/Keck Array or LiteBIRD, since it will enable an estimate to be made of the lensing-induced contribution to the measured total CMB B-modes.« less

Influence of day and night wear on surface properties of silicone hydrogel contact lenses and bacterial adhesion.

PubMed

Vermeltfoort, Pit B J; Rustema-Abbing, Minie; de Vries, Joop; Bruinsma, Gerda M; Busscher, Henk J; van der Linden, Matthijs L; Hooymans, Johanna M M; van der Mei, Henny C

2006-06-01

The aim of this study was to determine the effect of continuous wear on physicochemical surface properties of silicone hydrogel (S-H) lenses and their susceptibility to bacterial adhesion. In this study, volunteers wore 2 pairs of either "lotrafilcon A" or "balafilcon A" S-H contact lenses. The first pair was worn continuously for a week and the second pair for 4 weeks. One lens of each pair was used for surface characterization and the other one for bacterial adhesion experiments. Lens surfaces were characterized by examination of their wettability, roughness, elemental composition, and proteins attached to their surfaces. Adhesion of Staphylococcus aureus 835 and Pseudomonas aeruginosa #3 to a lens was studied using a parallel plate flow chamber. Before use, the lotrafilcon A lens was rougher than the balafilcon A lens and had a lower water contact angle and a higher affinity for S. aureus 835. After wear, both lens types had similar water contact angles, whereas the differences in elemental surface composition decreased as well. S. aureus 835 adhered in higher numbers to worn balafilcon A lenses, whereas the opposite was seen for P. aeruginosa #3. The initial deposition rates of both bacterial strains to lotrafilcon A lenses decreased by wearing and were found to correlate significant (P < 0.001) with the surface roughness of worn lenses. In this study, the differences in surface properties between 2 types of S-H lenses were found to change after 1 week of continuous wear. Generally, bacteria adhered in lower numbers and less tenaciously to worn lenses, except S. aureus 835, adhering in higher numbers to worn balafilcon A lenses.

Influence of protein deposition on bacterial adhesion to contact lenses.

PubMed

Subbaraman, Lakshman N; Borazjani, Roya; Zhu, Hua; Zhao, Zhenjun; Jones, Lyndon; Willcox, Mark D P

2011-08-01

The aim of the study is to determine the adhesion of Gram positive and Gram negative bacteria onto conventional hydrogel (CH) and silicone hydrogel (SH) contact lens materials with and without lysozyme, lactoferrin, and albumin coating. Four lens types (three SH-balafilcon A, lotrafilcon B, and senofilcon A; one CH-etafilcon A) were coated with lysozyme, lactoferrin, or albumin (uncoated lenses acted as controls) and then incubated in Staphylococcus aureus (Saur 31) or either of two strains of Pseudomonas aeruginosa (Paer 6294 and 6206) for 24 h at 37 °C. The total counts of the adhered bacteria were determined using the H-thymidine method and viable counts by counting the number of colony-forming units on agar media. All three strains adhered significantly lower to uncoated etafilcon A lenses compared with uncoated SH lenses (p < 0.05). Lysozyme coating on all four lens types increased binding (total and viable counts) of Saur 31 (p < 0.05). However, lysozyme coating did not influence P. aeruginosa adhesion (p > 0.05). Lactoferrin coating on lenses increased binding (total and viable counts) of Saur 31 (p < 0.05). Lactoferrin-coated lenses showed significantly higher total counts (p < 0.05) but significantly lower viable counts (p < 0.05) of adhered P. aeruginosa strains. There was a significant difference between the total and viable counts (p < 0.05) that were bound to lactoferrin-coated lenses. Albumin coating of lenses increased binding (total and viable counts) of all three strains (p < 0.05). Lysozyme deposited on contact lenses does not possess antibacterial activity against certain bacterial strains, whereas lactoferrin possess an antibacterial effect against strains of P. aeruginosa.

Water Exposure is a Common Risk Behavior Among Soft and Gas-Permeable Contact Lens Wearers

PubMed Central

Richdale, Kathryn; Mitchell, Gladys Lynn; Kinoshita, Beth T.; Lam, Dawn Y.; Wagner, Heidi; Sorbara, Luigina; Chalmers, Robin L.; Collier, Sarah A.; Cope, Jennifer R.; Rao, Maya M.; Beach, Michael J.; Yoder, Jonathan S.

2017-01-01

Purpose: To understand soft contact lens (SCL) and gas-permeable (GP) lens wearers' behaviors and knowledge regarding exposure of lenses to water. Methods: The Contact Lens Risk Survey (CLRS) and health behavior questions were completed online by a convenience sample of 1056 SCL and 85 GP lens wearers aged 20 to 76 years. Participants were asked about exposing their lenses to water and their understanding of risks associated with these behaviors. Chi-square analyses examined relationships between patient behaviors and perceptions. Results: GP lens wearers were more likely than SCL wearers to ever rinse or store lenses in water (rinsing: 91% GP, 31% SCL, P < 0.001; storing: 33% GP, 15% SCL P < 0.001). Among SCL wearers, men were more likely to store (24% vs. 13%, P = 0.003) or rinse (41% vs. 29%, P = 0.012) their lenses in water. Showering while wearing lenses was more common in SCL wearers (86%) than GP lens wearers (67%) (P < 0.0001). Swimming while wearing lenses was reported by 62% of SCL wearers and 48% of GP lens wearers (P = 0.027). Wearers who rinsed (SCL; P < 0.0001, GP; P = 0.11) or stored lenses in water (SCL; P < 0.0001, GP P = 0.007) reported that this behavior had little or no effect on their infection risk, compared with those who did not. Both SCL (P < 0.0001) and GP lens wearers (P < 0.0001) perceived that distilled water was safer than tap water for storing or rinsing lenses. Conclusions: Despite previously published evidence of Acanthamoeba keratitis' association with water exposure, most SCL, and nearly all GP lens wearers, regularly expose their lenses to water, with many unaware of the risk. PMID:28410356

The Effect of Size and Species on Lens Intracellular Hydrostatic Pressure

PubMed Central

Gao, Junyuan; Sun, Xiurong; Moore, Leon C.; Brink, Peter R.; White, Thomas W.; Mathias, Richard T.

2013-01-01

Purpose. Previous experiments showed that mouse lenses have an intracellular hydrostatic pressure that varied from 335 mm Hg in central fibers to 0 mm Hg in surface cells. Model calculations predicted that in larger lenses, all else equal, pressure should increase as the lens radius squared. To test this prediction, lenses of different radii from different species were studied. Methods. All studies were done in intact lenses. Intracellular hydrostatic pressures were measured with a microelectrode-manometer–based system. Membrane conductances were measured by frequency domain impedance analysis. Intracellular Na+ concentrations were measured by injecting the Na+-sensitive dye sodium-binding benzofuran isophthalate. Results. Intracellular hydrostatic pressures were measured in lenses from mice, rats, rabbits, and dogs with radii (cm) 0.11, 0.22, 0.49, and 0.57, respectively. In each species, pressure varied from 335 ± 6 mm Hg in central fiber cells to 0 mm Hg in surface cells. Further characterization of transport in lenses from mice and rats showed that the density of fiber cell gap junction channels was approximately the same, intracellular Na+ concentrations varied from 17 mM in central fiber cells to 7 mM in surface cells, and intracellular voltages varied from −45 mV in central fiber cells to −60 mV in surface cells. Fiber cell membrane conductance was a factor of 2.7 times larger in mouse than in rat lenses. Conclusions. Intracellular hydrostatic pressure is an important physiological parameter that is regulated in lenses from these different species. The most likely mechanism of regulation is to reduce the density of open Na+-leak channels in fiber cells of larger lenses. PMID:23211824

Planck intermediate results. XLI. A map of lensing-induced B-modes

NASA Astrophysics Data System (ADS)

Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davis, R. J.; de Bernardis, P.; de Zotti, G.; Delabrouille, J.; Dickinson, C.; Diego, J. M.; Doré, O.; Ducout, A.; Dupac, X.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gruppuso, A.; Gudmundsson, J. E.; Harrison, D. L.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hornstrup, A.; Hovest, W.; Hurier, G.; Jaffe, A. H.; Jones, W. C.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Leonardi, R.; Levrier, F.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Meinhold, P. R.; Melchiorri, A.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Novikov, D.; Novikov, I.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Rachen, J. P.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

2016-12-01

The secondary cosmic microwave background (CMB) B-modes stem from the post-decoupling distortion of the polarization E-modes due to the gravitational lensing effect of large-scale structures. These lensing-induced B-modes constitute both a valuable probe of the dark matter distribution and an important contaminant for the extraction of the primary CMB B-modes from inflation. Planck provides accurate nearly all-sky measurements of both the polarization E-modes and the integrated mass distribution via the reconstruction of the CMB lensing potential. By combining these two data products, we have produced an all-sky template map of the lensing-induced B-modes using a real-space algorithm that minimizes the impact of sky masks. The cross-correlation of this template with an observed (primordial and secondary) B-mode map can be used to measure the lensing B-mode power spectrum at multipoles up to 2000. In particular, when cross-correlating with the B-mode contribution directly derived from the Planck polarization maps, we obtain lensing-induced B-mode power spectrum measurement at a significance level of 12σ, which agrees with the theoretical expectation derived from the Planck best-fit Λ cold dark matter model. This unique nearly all-sky secondary B-mode template, which includes the lensing-induced information from intermediate to small (10 ≲ ℓ ≲ 1000) angular scales, is delivered as part of the Planck 2015 public data release. It will be particularly useful for experiments searching for primordial B-modes, such as BICEP2/Keck Array or LiteBIRD, since it will enable an estimate to be made of the lensing-induced contribution to the measured total CMB B-modes.

Water Exposure is a Common Risk Behavior Among Soft and Gas-Permeable Contact Lens Wearers.

PubMed

Zimmerman, Aaron B; Richdale, Kathryn; Mitchell, Gladys Lynn; Kinoshita, Beth T; Lam, Dawn Y; Wagner, Heidi; Sorbara, Luigina; Chalmers, Robin L; Collier, Sarah A; Cope, Jennifer R; Rao, Maya M; Beach, Michael J; Yoder, Jonathan S

2017-08-01

To understand soft contact lens (SCL) and gas-permeable (GP) lens wearers' behaviors and knowledge regarding exposure of lenses to water. The Contact Lens Risk Survey (CLRS) and health behavior questions were completed online by a convenience sample of 1056 SCL and 85 GP lens wearers aged 20 to 76 years. Participants were asked about exposing their lenses to water and their understanding of risks associated with these behaviors. Chi-square analyses examined relationships between patient behaviors and perceptions. GP lens wearers were more likely than SCL wearers to ever rinse or store lenses in water (rinsing: 91% GP, 31% SCL, P < 0.001; storing: 33% GP, 15% SCL P < 0.001). Among SCL wearers, men were more likely to store (24% vs. 13%, P = 0.003) or rinse (41% vs. 29%, P = 0.012) their lenses in water. Showering while wearing lenses was more common in SCL wearers (86%) than GP lens wearers (67%) (P < 0.0001). Swimming while wearing lenses was reported by 62% of SCL wearers and 48% of GP lens wearers (P = 0.027). Wearers who rinsed (SCL; P < 0.0001, GP; P = 0.11) or stored lenses in water (SCL; P < 0.0001, GP P = 0.007) reported that this behavior had little or no effect on their infection risk, compared with those who did not. Both SCL (P < 0.0001) and GP lens wearers (P < 0.0001) perceived that distilled water was safer than tap water for storing or rinsing lenses. Despite previously published evidence of Acanthamoeba keratitis' association with water exposure, most SCL, and nearly all GP lens wearers, regularly expose their lenses to water, with many unaware of the risk.

Planck intermediate results: XLI. A map of lensing-induced B-modes

DOE PAGES

Ade, P. A. R.; Aghanim, N.; Ashdown, M.; ...

2016-12-12

The secondary cosmic microwave background (CMB) B-modes stem from the post-decoupling distortion of the polarization E-modes due to the gravitational lensing effect of large-scale structures. These lensing-induced B-modes constitute both a valuable probe of the dark matter distribution and an important contaminant for the extraction of the primary CMB B-modes from inflation. Planck provides accurate nearly all-sky measurements of both the polarization E-modes and the integrated mass distribution via the reconstruction of the CMB lensing potential. By combining these two data products, we have produced in this paper an all-sky template map of the lensing-induced B-modes using a real-space algorithmmore » that minimizes the impact of sky masks. The cross-correlation of this template with an observed (primordial and secondary) B-mode map can be used to measure the lensing B-mode power spectrum at multipoles up to 2000. In particular, when cross-correlating with the B-mode contribution directly derived from the Planck polarization maps, we obtain lensing-induced B-mode power spectrum measurement at a significance level of 12σ, which agrees with the theoretical expectation derived from the Planck best-fit Λ cold dark matter model. This unique nearly all-sky secondary B-mode template, which includes the lensing-induced information from intermediate to small (10 ≲ ℓ ≲ 1000) angular scales, is delivered as part of the Planck 2015 public data release. Finally, it will be particularly useful for experiments searching for primordial B-modes, such as BICEP2/Keck Array or LiteBIRD, since it will enable an estimate to be made of the lensing-induced contribution to the measured total CMB B-modes.« less

The effects of velocities and lensing on moments of the Hubble diagram

NASA Astrophysics Data System (ADS)

Macaulay, E.; Davis, T. M.; Scovacricchi, D.; Bacon, D.; Collett, T.; Nichol, R. C.

2017-05-01

We consider the dispersion on the supernova distance-redshift relation due to peculiar velocities and gravitational lensing, and the sensitivity of these effects to the amplitude of the matter power spectrum. We use the Method-of-the-Moments (MeMo) lensing likelihood developed by Quartin et al., which accounts for the characteristic non-Gaussian distribution caused by lensing magnification with measurements of the first four central moments of the distribution of magnitudes. We build on the MeMo likelihood by including the effects of peculiar velocities directly into the model for the moments. In order to measure the moments from sparse numbers of supernovae, we take a new approach using Kernel density estimation to estimate the underlying probability density function of the magnitude residuals. We also describe a bootstrap re-sampling approach to estimate the data covariance matrix. We then apply the method to the joint light-curve analysis (JLA) supernova catalogue. When we impose only that the intrinsic dispersion in magnitudes is independent of redshift, we find σ _8=0.44^{+0.63}_{-0.44} at the one standard deviation level, although we note that in tests on simulations, this model tends to overestimate the magnitude of the intrinsic dispersion, and underestimate σ8. We note that the degeneracy between intrinsic dispersion and the effects of σ8 is more pronounced when lensing and velocity effects are considered simultaneously, due to a cancellation of redshift dependence when both effects are included. Keeping the model of the intrinsic dispersion fixed as a Gaussian distribution of width 0.14 mag, we find σ _8 = 1.07^{+0.50}_{-0.76}.

98. DETAIL VIEW OF STORM DAMAGE AND EXPOSED SUBSTRUCTURE, NORTHWEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

98. DETAIL VIEW OF STORM DAMAGE AND EXPOSED SUBSTRUCTURE, NORTHWEST SIDE OF 4TH TEE, LOOKING WEST - Huntington Beach Municipal Pier, Pacific Coast Highway at Main Street, Huntington Beach, Orange County, CA

2. Substructure of the main dock, looking south beneath the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Substructure of the main dock, looking south beneath the Hay and Grain Warehouse. Original log pilings have been encased in concrete. - Curtis Wharf, Main Dock, O & Second Streets, Anacortes, Skagit County, WA

Research on simplified parametric finite element model of automobile frontal crash

NASA Astrophysics Data System (ADS)

Wu, Linan; Zhang, Xin; Yang, Changhai

2018-05-01

The modeling method and key technologies of the automobile frontal crash simplified parametric finite element model is studied in this paper. By establishing the auto body topological structure, extracting and parameterizing the stiffness properties of substructures, choosing appropriate material models for substructures, the simplified parametric FE model of M6 car is built. The comparison of the results indicates that the simplified parametric FE model can accurately calculate the automobile crash responses and the deformation of the key substructures, and the simulation time is reduced from 6 hours to 2 minutes.

Estrogen Protects Lenses against Cataract Induced by Transforming Growth Factor-β (TGFβ)

PubMed Central

Hales, Angela M.; Chamberlain, Coral G.; Murphy, Christopher R.; McAvoy, John W.

1997-01-01

Cataract, already a major cause of visual impairment and blindness, is likely to become an increasing problem as the world population ages. In a previous study, we showed that transforming growth factor-β (TGFβ) induces rat lenses in culture to develop opacities and other changes that have many features of human subcapsular cataracts. Here we show that estrogen protects against cataract. Lenses from female rats are more resistant to TGFβ-induced cataract than those from males. Furthermore, lenses from ovariectomized females show increased sensitivity to the damaging effects of TGFβ and estrogen replacement in vivo, or exposure to estrogen in vitro, restores resistance. Sex-dependent and estrogen-related differences in susceptibility to cataract formation, consistent with a protective role for estrogen, have been noted in some epidemiological studies. The present study in the rat indicates that estrogen provides protection against cataract by countering the damaging effects of TGFβ. It also adds to an increasing body of evidence that hormone replacement therapy protects postmenopausal women against various diseases. PMID:9016876

Long-term effects of the daily wear of senofilcon A silicone hydrogel contact lenses on corneal and conjunctival tissues.

PubMed

Guillon, Michel; Maïssa, Cécile

2010-12-01

The objective of the investigation was to show that, because of their overall properties, Acuvue® Oasys™ with Hydraclear® Plus brand (senofilcon A) silicone hydrogel contact lenses achieve excellent ocular tissue tolerance during long-term daily wear. The 2-year investigation was a prospective daily wear analysis of Acuvue® Oasys™ with Hydraclear® Plus (senofilcon A) silicone hydrogel contact lenses replaced every 2 weeks and used in conjunction with a representative range of care systems. The 2-year results compared with the subjects' baseline ocular status on entering the study revealed: The quantification of the effects on the ocular tissues of 2 years of daily wear of senofilcon A, by mainly previously successful daily soft contact lens wearers, showed an excellent biocompatibility. The results support the hypothesis that senofilcon A contact lenses, when worn on a 2-week daily wear regimen, maintain excellent long-term ocular tissue tolerance. Copyright © 2010 American Optometric Association. Published by Elsevier Inc. All rights reserved.

Hippocampal sclerosis: volumetric evaluation of the substructures of the hippocampus by magnetic resonance imaging.

PubMed

Granados Sánchez, A M; Orejuela Zapata, J F

2018-05-25

The pathological classification of hippocampal sclerosis is based on the loss of neurons in the substructures of the hippocampus. This study aimed to evaluate these substructures in patients with hippocampal sclerosis by magnetic resonance imaging and to compare the usefulness of this morphological analysis compared to that of volumetric analysis of the entire hippocampus. We included 25 controls and 25 patients with hippocampal sclerosis whose diagnosis was extracted from the institutional epilepsy board. We used FreeSurfer to process the studies and obtain the volumetric data. We evaluated overall volume and volume by substructure: fimbria, subiculum, presubiculum, hippocampal sulcus, CA1, CA2-CA3, CA4, and dentate gyrus (DG). We considered p < 0.05 statistically significant. We observed statistically significant decreases in the volume of the hippocampus ipsilateral to the epileptogenic focus in 19 (76.0%) of the 25 cases. With the exception of the hippocampal sulcus, we observed a decrease in all ipsilateral hippocampal substructures in patients with right hippocampal sclerosis (CA1, p=0.0223; CA2-CA3, p=0.0066; CA4-GD, p=0.0066; fimbria, p=0.0046; presubiculum, p=0.0087; subiculum, p=0.0017) and in those with left hippocampal sclerosis (CA1, p<0.0001; CA2-CA3, p<0. 0001; CA4-GD, p<0. 0001; fimbria, p=0.0183; presubiculum, p<0. 0001; subiculum, p<0. 0001). In four patients with left hippocampal sclerosis, none of the substructures had statistically significant alterations, although a trend toward atrophy was observed, mainly in CA2-CA3 and CA4-GD. The findings suggest that it can be useful to assess the substructures of the hippocampus to improve the performance of diagnostic imaging in patients with hippocampal sclerosis. Copyright © 2018 SERAM. Publicado por Elsevier España, S.L.U. All rights reserved.

A method to quantify hand-transmitted vibration exposure based on the biodynamic stress concept.

PubMed

Dong, R G; Welcome, D E; Wu, J Z

2007-11-01

This study generally hypothesized that the vibration-induced biodynamic stress and number of its cycles in a substructure of the hand-arm system play an important role in the development of vibration-induced disorders in the substructure. As the first step to test this hypothesis, the specific aims of this study were to develop a practical method to quantify the biodynamic stress-cycle measure, to compare it with ISO-weighted and unweighted accelerations, and to assess its potential for applications. A mechanical-equivalent model of the system was established using reported experimental data. The model was used to estimate the average stresses in the fingers and palm. The frequency weightings of the stresses in these substructures were derived using the proposed stress-cycle measure. This study found the frequency dependence of the average stress distributed in the fingers is different from that in the palm. Therefore, this study predicted that the frequency dependencies of finger disorders could also be different from those of the disorders in the palm, wrist, and arms. If vibration-induced white finger (VWF) is correlated better with unweighted acceleration than with ISO-weighted acceleration, the biodynamic stress distributed in the fingers is likely to play a more important role in the development of VWF than is th e biodynamic stressdistributed in the other substructures of the hand-arm system. The results of this study also suggest that the ISO weighting underestimates the high-frequency effect on the finger disorder development but it may provide a reasonable risk assessment of the disorders in the wrist and arm.

Optical effects of exposing intact human lenses to ultraviolet radiation and visible light.

PubMed

Kessel, Line; Eskildsen, Lars; Lundeman, Jesper Holm; Jensen, Ole Bjarlin; Larsen, Michael

2011-12-30

The human lens is continuously exposed to high levels of light. Ultraviolet radiation is believed to play a causative role in the development of cataract. In vivo, however, the lens is mainly exposed to visible light and the ageing lens absorbs a great part of the short wavelength region of incoming visible light. The aim of the present study was to examine the optical effects on human lenses of short wavelength visible light and ultraviolet radiation. Naturally aged human donor lenses were irradiated with UVA (355 nm), violet (400 and 405 nm) and green (532 nm) lasers. The effect of irradiation was evaluated qualitatively by photography and quantitatively by measuring the direct transmission before and after irradiation. Furthermore, the effect of pulsed and continuous laser systems was compared as was the effect of short, intermediate and prolonged exposures. Irradiation with high intensity lasers caused scattering lesions in the human lenses. These effects were more likely to be seen when using pulsed lasers because of the high pulse intensity. Prolonged irradiation with UVA led to photodarkening whereas no detrimental effects were observed after irradiation with visible light. Irradiation with visible light does not seem to be harmful to the human lens except if the lens is exposed to laser irradiances that are high enough to warrant thermal protein denaturation that is more readily seen using pulsed laser systems.

Rapid bridge construction technology : precast elements for substructures.

DOT National Transportation Integrated Search

2011-06-01

The goal of this research was to propose an alternate system of precast bridge substructures which can : substitute for conventional cast in place systems in Wisconsin to achieve accelerated construction. : Three types of abutment modules (hollow wal...

13. VIEW OF SUBSTRUCTURE CONNECTIONS WITH TRUSS MEMBERS, SUSPENSION CABLES ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. VIEW OF SUBSTRUCTURE CONNECTIONS WITH TRUSS MEMBERS, SUSPENSION CABLES AND 'I'-BEAMS, NORTHEAST SIDE OF BRIDGE, LOOKING WEST - San Rafael Bridge, Spanning San Rafael River near Buckhorn Wash, Castle Dale, Emery County, UT

Repair of deteriorated bridge substructures : [summary].

DOT National Transportation Integrated Search

2013-05-01

Degradation of bridge substructure members in Wisconsin is a serious concern. Concrete, steel and timber members all require distinct repair methods which not only address the true cause of the deterioration, but also protect the members from future ...

Large-deformation modal coordinates for nonrigid vehicle dynamics

NASA Technical Reports Server (NTRS)

Likins, P. W.; Fleischer, G. E.

1972-01-01

The derivation of minimum-dimension sets of discrete-coordinate and hybrid-coordinate equations of motion of a system consisting of an arbitrary number of hinge-connected rigid bodies assembled in tree topology is presented. These equations are useful for the simulation of dynamical systems that can be idealized as tree-like arrangements of substructures, with each substructure consisting of either a rigid body or a collection of elastically interconnected rigid bodies restricted to small relative rotations at each connection. Thus, some of the substructures represent elastic bodies subjected to small strains or local deformations, but possibly large gross deformations, in the hybrid formulation, distributed coordinates referred to herein as large-deformation modal coordinates, are used for the deformations of these substructures. The equations are in a form suitable for incorporation into one or more computer programs to be used as multipurpose tools in the simulation of spacecraft and other complex electromechanical systems.

Turbine vane with high temperature capable skins

DOEpatents

Morrison, Jay A [Oviedo, FL

2012-07-10

A turbine vane assembly includes an airfoil extending between an inner shroud and an outer shroud. The airfoil can include a substructure having an outer peripheral surface. At least a portion of the outer peripheral surface is covered by an external skin. The external skin can be made of a high temperature capable material, such as oxide dispersion strengthened alloys, intermetallic alloys, ceramic matrix composites or refractory alloys. The external skin can be formed, and the airfoil can be subsequently bi-cast around or onto the skin. The skin and the substructure can be attached by a plurality of attachment members extending between the skin and the substructure. The skin can be spaced from the outer peripheral surface of the substructure such that a cavity is formed therebetween. Coolant can be supplied to the cavity. Skins can also be applied to the gas path faces of the inner and outer shrouds.

ALMA Observations of Starless Core Substructure in Ophiuchus

NASA Astrophysics Data System (ADS)

Kirk, H.; Dunham, M. M.; Di Francesco, J.; Johnstone, D.; Offner, S. S. R.; Sadavoy, S. I.; Tobin, J. J.; Arce, H. G.; Bourke, T. L.; Mairs, S.; Myers, P. C.; Pineda, J. E.; Schnee, S.; Shirley, Y. L.

2017-04-01

Compact substructure is expected to arise in a starless core as mass becomes concentrated in the central region likely to form a protostar. Additionally, multiple peaks may form if fragmentation occurs. We present Atacama Large Millimeter/submillimeter Array (ALMA) Cycle 2 observations of 60 starless and protostellar cores in the Ophiuchus molecular cloud. We detect eight compact substructures which are > 15\\prime\\prime from the nearest Spitzer young stellar object. Only one of these has strong evidence for being truly starless after considering ancillary data, e.g., from Herschel and X-ray telescopes. An additional extended emission structure has tentative evidence for starlessness. The number of our detections is consistent with estimates from a combination of synthetic observations of numerical simulations and analytical arguments. This result suggests that a similar ALMA study in the Chamaeleon I cloud, which detected no compact substructure in starless cores, may be due to the peculiar evolutionary state of cores in that cloud.

Offshore platform structure intended to be installed in arctic waters, subjected to drifting icebergs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kure, G.; Jenssen, D.N.; Naesje, K.

1984-09-11

An offshore platform structure, particularly intended to be installed in waters where drifting iceberg frequently appear, the platform structure being intended to be founded in a sea bed and comprises a substructure, a superstructure rigidly affixed to the substructure and extending vertically up above the sea level supporting a deck superstructure at its upper end. The horizontal cross-sectional area of the substructure is substantially greater than tath of the superstructure. The substructure rigidly supports a fender structure, the fender structure comprising an outer peripherally arranged wall and an inner cylindrical wall the inner and outer wall being rigidly interconnected bymore » means of a plurality of vertical and/or horizontal partition walls, dividing the fender structure into a plurality of cells or compartlents. The fender structure is arranged in spaced relation with respect to the superstructure.« less

Application of the mobility power flow approach to structural response from distributed loading

NASA Technical Reports Server (NTRS)

Cuschieri, J. M.

1988-01-01

The problem of the vibration power flow through coupled substructures when one of the substructures is subjected to a distributed load is addressed. In all the work performed thus far, point force excitation was considered. However, in the case of the excitation of an aircraft fuselage, distributed loading on the whole surface of a panel can be as important as the excitation from directly applied forces at defined locations on the structures. Thus using a mobility power flow approach, expressions are developed for the transmission of vibrational power between two coupled plate substructures in an L configuration, with one of the surfaces of one of the plate substructures being subjected to a distributed load. The types of distributed loads that are considered are a force load with an arbitrary function in space and a distributed load similar to that from acoustic excitation.

Concrete bridge deck condition assessment and improvement strategies.

DOT National Transportation Integrated Search

2004-11-01

The aging and deterioration of bridges in Utah mandates increasingly cost-effective strategies for bridge maintenance, rehabilitation, and repair (MR&R). Although the substructures and superstructures of bridges in Utah are in relatively good structu...

Beam aperture modifier design with acoustic metasurfaces

NASA Astrophysics Data System (ADS)

Tang, Weipeng; Ren, Chunyu

2017-10-01

In this paper, we present a design concept of acoustic beam aperture modifier using two metasurface-based planar lenses. By appropriately designing the phase gradient profile along the metasurface, we obtain a class of acoustic convex lenses and concave lenses, which can focus the incoming plane waves and collimate the converging waves, respectively. On the basis of the high converging and diverging capability of these lenses, two kinds of lens combination scheme, including the convex-concave type and convex-convex type, are proposed to tune up the incoming beam aperture as needed. To be specific, the aperture of the acoustic beam can be shrunk or expanded through adjusting the phase gradient of the pair of lenses and the spacing between them. These lenses and the corresponding aperture modifiers are constructed by the stacking ultrathin labyrinthine structures, which are obtained by the geometry optimization procedure and exhibit high transmission coefficient and a full range of phase shift. The simulation results demonstrate the effectiveness of our proposed beam aperture modifiers. Due to the flexibility in aperture controlling and the simplicity in fabrication, the proposed modifiers have promising potential in applications, such as acoustic imaging, nondestructive evaluation, and communication.

The Top 10 List of Gravitational Lens Candidates from the HUBBLE SPACE TELESCOPE Medium Deep Survey

NASA Astrophysics Data System (ADS)

Ratnatunga, Kavan U.; Griffiths, Richard E.; Ostrander, Eric J.

1999-05-01

A total of 10 good candidates for gravitational lensing have been discovered in the WFPC2 images from the Hubble Space Telescope (HST) Medium Deep Survey (MDS) and archival primary observations. These candidate lenses are unique HST discoveries, i.e., they are faint systems with subarcsecond separations between the lensing objects and the lensed source images. Most of them are difficult objects for ground-based spectroscopic confirmation or for measurement of the lens and source redshifts. Seven are ``strong lens'' candidates that appear to have multiple images of the source. Three are cases in which the single image of the source galaxy has been significantly distorted into an arc. The first two quadruply lensed candidates were reported by Ratnatunga et al. We report on the subsequent eight candidates and describe them with simple models based on the assumption of singular isothermal potentials. Residuals from the simple models for some of the candidates indicate that a more complex model for the potential will probably be required to explain the full structural detail of the observations once they are confirmed to be lenses. We also discuss the effective survey area that was searched for these candidate lens objects.

The Effects of Irlen Colored Lenses on Students' Specific Reading Skills and Their Perception of Ability: A 12-Month Validity Study.

ERIC Educational Resources Information Center

Robinson, Gregory L. W.; Conway, Robert N. F.

1990-01-01

The study examined the effectiveness of the use of nonoptical tinted (Irlen) lenses with 44 children (ages 9-16) with reading disabilities. Evaluation after 6 and 12 months indicated a significant improvement in attitude to school and to basic academic skills. Reading comprehension and accuracy, but not rate, were also significantly improved.…

Novel Approaches in Formulation and Drug Delivery using Contact Lenses

PubMed Central

Singh, Kishan; Nair, Anroop B; Kumar, Ashok; Kumria, Rachna

2011-01-01

The success of ocular delivery relies on the potential to enhance the drug bioavailability by controlled and extended release of drug on the eye surface. Several new approaches have been attempted to augment the competence and diminish the intrinsic side effects of existing ocular drug delivery systems. In this contest, progress has been made to develop drug-eluting contact lens using different techniques, which have the potential to control and sustain the delivery of drug. Further, the availability of novel polymers have facilitated and promoted the utility of contact lenses in ocular drug delivery. Several research groups have already explored the feasibility and potential of contact lens using conventional drugs for the treatment of periocular and intraocular diseases. Contact lenses formulated using modern technology exhibits high loading, controlled drug release, apposite thickness, water content, superior mechanical and optical properties as compared to commercial lenses. In general, this review discus various factors and approaches designed and explored for the successful delivery of ophthalmic drugs using contact lenses as drug delivery device PMID:24826007

Integration of Defocus by Dual Power Fresnel Lenses Inhibits Myopia in the Mammalian Eye

PubMed Central

McFadden, Sally A.; Tse, Dennis Y.; Bowrey, Hannah E.; Leotta, Amelia J.; Lam, Carly S.; Wildsoet, Christine F.; To, Chi-Ho

2014-01-01

Purpose. Eye growth compensates in opposite directions to single vision (SV) negative and positive lenses. We evaluated the response of the guinea pig eye to Fresnel-type lenses incorporating two different powers. Methods. A total of 114 guinea pigs (10 groups with 9–14 in each) wore a lens over one eye and interocular differences in refractive error and ocular dimensions were measured in each of three experiments. First, the effects of three Fresnel designs with various diopter (D) combinations (−5D/0D; +5D/0D or −5D/+5D dual power) were compared to three SV lenses (−5D, +5D, or 0D). Second, the ratio of −5D and +5D power in a Fresnel lens was varied (50:50 compared with 60:40). Third, myopia was induced by 4 days of exposure to a SV −5D lens, which was then exchanged for a Fresnel lens (−5D/+5D) or one of two SV lenses (+5D or −5D) and ocular parameters tracked for a further 3 weeks. Results. Dual power lenses induced an intermediate response between that to the two constituent powers (lenses +5D, +5D/0D, 0D, −5D/+5D, −5D/0D and −5D induced +2.1 D, +0.7 D, +0.1 D, −0.3 D, −1.6 D and −5.1 D in mean intraocular differences in refractive error, respectively), and changing the ratio of powers induced responses equal to their weighted average. In already myopic animals, continued treatment with SV negative lenses increased their myopia (from −3.3 D to −4.2 D), while switching to SV positive lenses or −5D/+5D Fresnel lenses reduced their myopia (by 2.9 D and 2.3 D, respectively). Conclusions. The mammalian eye integrates competing defocus to guide its refractive development and eye growth. Fresnel lenses, incorporating positive or plano power with negative power, can slow ocular growth, suggesting that such designs may control myopia progression in humans. PMID:24398103

Integration of defocus by dual power Fresnel lenses inhibits myopia in the mammalian eye.

PubMed

McFadden, Sally A; Tse, Dennis Y; Bowrey, Hannah E; Leotta, Amelia J; Lam, Carly S; Wildsoet, Christine F; To, Chi-Ho

2014-02-14

Eye growth compensates in opposite directions to single vision (SV) negative and positive lenses. We evaluated the response of the guinea pig eye to Fresnel-type lenses incorporating two different powers. A total of 114 guinea pigs (10 groups with 9-14 in each) wore a lens over one eye and interocular differences in refractive error and ocular dimensions were measured in each of three experiments. First, the effects of three Fresnel designs with various diopter (D) combinations (-5D/0D; +5D/0D or -5D/+5D dual power) were compared to three SV lenses (-5D, +5D, or 0D). Second, the ratio of -5D and +5D power in a Fresnel lens was varied (50:50 compared with 60:40). Third, myopia was induced by 4 days of exposure to a SV -5D lens, which was then exchanged for a Fresnel lens (-5D/+5D) or one of two SV lenses (+5D or -5D) and ocular parameters tracked for a further 3 weeks. Dual power lenses induced an intermediate response between that to the two constituent powers (lenses +5D, +5D/0D, 0D, -5D/+5D, -5D/0D and -5D induced +2.1 D, +0.7 D, +0.1 D, -0.3 D, -1.6 D and -5.1 D in mean intraocular differences in refractive error, respectively), and changing the ratio of powers induced responses equal to their weighted average. In already myopic animals, continued treatment with SV negative lenses increased their myopia (from -3.3 D to -4.2 D), while switching to SV positive lenses or -5D/+5D Fresnel lenses reduced their myopia (by 2.9 D and 2.3 D, respectively). The mammalian eye integrates competing defocus to guide its refractive development and eye growth. Fresnel lenses, incorporating positive or plano power with negative power, can slow ocular growth, suggesting that such designs may control myopia progression in humans.

THE GINI COEFFICIENT AS A MORPHOLOGICAL MEASUREMENT OF STRONGLY LENSED GALAXIES IN THE IMAGE PLANE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Florian, Michael K.; Li, Nan; Gladders, Michael D.

2016-12-01

Characterization of the morphology of strongly lensed galaxies is challenging because images of such galaxies are typically highly distorted. Lens modeling and source plane reconstruction is one approach that can provide reasonably undistorted images from which morphological measurements can be made, though at the expense of a highly spatially variable telescope point-spread function (PSF) when mapped back to the source plane. Unfortunately, modeling the lensing mass is a time- and resource-intensive process, and in many cases there are too few constraints to precisely model the lensing mass. If, however, useful morphological measurements could be made in the image plane rathermore » than the source plane, it would bypass this issue and obviate the need for a source reconstruction process for some applications. We examine the use of the Gini coefficient as one such measurement. Because it depends on the cumulative distribution of the light of a galaxy, but not the relative spatial positions, the fact that surface brightness is conserved by lensing means that the Gini coefficient may be well preserved by strong gravitational lensing. Through simulations, we test the extent to which the Gini coefficient is conserved, including by effects due to PSF convolution and pixelization, to determine whether it is invariant enough under lensing to be used as a measurement of galaxy morphology that can be made in the image plane.« less

The GINI coefficient as a morphological measurement of strongly lensed galaxies in the image plane

DOE Office of Scientific and Technical Information (OSTI.GOV)

Florian, Michael K.; Li, Nan; Gladders, Michael D.

2016-11-30

Characterization of the morphology of strongly lensed galaxies is challenging because images of such galaxies are typically highly distorted. Lens modeling and source plane reconstruction is one approach that can provide reasonably undistorted images from which morphological measurements can be made, though at the expense of a highly spatially variable telescope point-spread function (PSF) when mapped back to the source plane. Unfortunately, modeling the lensing mass is a time-and resource-intensive process, and in many cases there are too few constraints to precisely model the lensing mass. If, however, useful morphological measurements could be made in the image plane rather thanmore » the source plane, it would bypass this issue and obviate the need for a source reconstruction process for some applications. We examine the use of the Gini coefficient as one such measurement. Because it depends on the cumulative distribution of the light of a galaxy, but not the relative spatial positions, the fact that surface brightness is conserved by lensing means that the Gini coefficient may be well preserved by strong gravitational lensing. Through simulations, we test the extent to which the Gini coefficient is conserved, including by effects due to PSF convolution and pixelization, to determine whether it is invariant enough under lensing to be used as a measurement of galaxy morphology that can be made in the image plane.« less

Testing the MOND paradigm of modified dynamics with galaxy-galaxy gravitational lensing.

PubMed

Milgrom, Mordehai

2013-07-26

The MOND paradigm of modified dynamics predicts that the asymptotic gravitational potential of an isolated, bounded (baryonic) mass, M, is ϕ(r)=(MGa0)1/2ln(r). Relativistic MOND theories predict that the lensing effects of M are dictated by ϕ(r) as general-relativity lensing is dictated by the Newtonian potential. Thus MOND predicts that the asymptotic Newtonian potential deduced from galaxy-galaxy gravitational lensing will have (1) a logarithmic r dependence, and (2) a normalization (parametrized standardly as 2σ2) that depends only on M: σ=(MGa0/4)1/4. I compare these predictions with recent results of galaxy-galaxy lensing, and find agreement on all counts. For the “blue”-lenses subsample (“spiral” galaxies) MOND reproduces the observations well with an r′-band M/Lr′∼(1–3)(M/L)⊙, and for “red” lenses (“elliptical” galaxies) with M/Lr′∼(3–6)(M/L)⊙, both consistent with baryons only. In contradistinction, Newtonian analysis requires, typically, M/Lr′∼130(M/L)⊙, bespeaking a mass discrepancy of a factor ∼40. Compared with the staple, rotation-curve tests, MOND is here tested in a wider population of galaxies, through a different phenomenon, using relativistic test objects, and is probed to several-times-lower accelerations–as low as a few percent of a0.

Interferometric characterization of pyroelectrically activated micro-arrays of liquid lenses in lithium niobate crystals

NASA Astrophysics Data System (ADS)

Grilli, S.; Miccio, L.; Vespini, V.; Ferraro, P.

2008-08-01

In recent years a wide variety of liquid based optical elements have been conceived, designed and fabricated even for commercial products like digital cameras. The impressive development of microfluidic systems in conjunction with optics has led to the creation of a completely new field of investigation named optofludics. Among other things, the optofluidic area deals with the investigation and the realization of liquid micro-lenses. Different methods and configurations have been proposed in literature to achieve liquid variable micro-lenses. This paper reports about the possibility to achieve lensing effect by a relatively easy to accomplish technique based on an open microfluidic system consisting of a tiny amount of appropriate liquid manipulated by the pyroelectric effect onto a periodically poled LiNbO3 substrate. Basically, an electrowetting process is performed to actuate the liquid film by using the surface charges generated pyroelectrically under temperature variation. The configuration is electrode-less compared to standard electrowetting systems, thus improving the device flexibility and easiness of fabrication. The curvature of the liquid lenses has been characterized by interferometric techniques based on the evaluation of the phase map through digital holography. The results showing the evolution of the lens curvature with the temperature variation will be presented and discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carron, Julien; Lewis, Antony; Challinor, Anthony, E-mail: j.carron@sussex.ac.uk, E-mail: Antony.Lewis@sussex.ac.uk, E-mail: a.d.challinor@ast.cam.ac.uk

We present a first internal delensing of CMB maps, both in temperature and polarization, using the public foreground-cleaned (SMICA) Planck 2015 maps. After forming quadratic estimates of the lensing potential, we use the corresponding displacement field to undo the lensing on the same data. We build differences of the delensed spectra to the original data spectra specifically to look for delensing signatures. After taking into account reconstruction noise biases in the delensed spectra, we find an expected sharpening of the power spectrum acoustic peaks with a delensing efficiency of 29 % ( TT ) 25 % ( TE ) andmore » 22 % ( EE ). The detection significance of the delensing effects is very high in all spectra: 12 σ in EE polarization; 18 σ in TE ; and 20 σ in TT . The null hypothesis of no lensing in the maps is rejected at 26 σ. While direct detection of the power in lensing B -modes themselves is not possible at high significance at Planck noise levels, we do detect (at 4.5 σ (under the null hypothesis)) delensing effects in the B -mode map, with 7 % reduction in lensing power. Our results provide a first demonstration of polarization delensing, and generally of internal CMB delensing, and stand in agreement with the baseline ΛCDM Planck 2015 cosmology expectations.« less

Identification of population substructure among Jews using STR markers and dependence on reference populations included.

PubMed

Listman, Jennifer B; Hasin, Deborah; Kranzler, Henry R; Malison, Robert T; Mutirangura, Apiwat; Sughondhabirom, Atapol; Aharonovich, Efrat; Spivak, Baruch; Gelernter, Joel

2010-06-14

Detecting population substructure is a critical issue for association studies of health behaviors and other traits. Whether inherent in the population or an artifact of marker choice, determining aspects of a population's genetic history as potential sources of substructure can aid in design of future genetic studies. Jewish populations, among which association studies are often conducted, have a known history of migrations. As a necessary step in understanding population structure to conduct valid association studies of health behaviors among Israeli Jews, we investigated genetic signatures of this history and quantified substructure to facilitate future investigations of these phenotypes in this population. Using 32 autosomal STR markers and the program STRUCTURE, we differentiated between Ashkenazi (AJ, N = 135) and non-Ashkenazi (NAJ, N = 226) Jewish populations in the form of Northern and Southern geographic genetic components (AJ north 73%, south 23%, NAJ north 33%, south 60%). The ability to detect substructure within these closely related populations using a small STR panel was contingent on including additional samples representing major continental populations in the analyses. Although clustering programs such as STRUCTURE are designed to assign proportions of ancestry to individuals without reference population information, when Jewish samples were analyzed in the absence of proxy parental populations, substructure within Jews was not detected. Generally, for samples with a given grandparental country of birth, STRUCTURE assignment values to Northern, Southern, African and Asian clusters agreed with mitochondrial DNA and Y-chromosomal data from previous studies as well as historical records of migration and intermarriage.

Identification of population substructure among Jews using STR markers and dependence on reference populations included

PubMed Central

2010-01-01

Background Detecting population substructure is a critical issue for association studies of health behaviors and other traits. Whether inherent in the population or an artifact of marker choice, determining aspects of a population's genetic history as potential sources of substructure can aid in design of future genetic studies. Jewish populations, among which association studies are often conducted, have a known history of migrations. As a necessary step in understanding population structure to conduct valid association studies of health behaviors among Israeli Jews, we investigated genetic signatures of this history and quantified substructure to facilitate future investigations of these phenotypes in this population. Results Using 32 autosomal STR markers and the program STRUCTURE, we differentiated between Ashkenazi (AJ, N = 135) and non-Ashkenazi (NAJ, N = 226) Jewish populations in the form of Northern and Southern geographic genetic components (AJ north 73%, south 23%, NAJ north 33%, south 60%). The ability to detect substructure within these closely related populations using a small STR panel was contingent on including additional samples representing major continental populations in the analyses. Conclusions Although clustering programs such as STRUCTURE are designed to assign proportions of ancestry to individuals without reference population information, when Jewish samples were analyzed in the absence of proxy parental populations, substructure within Jews was not detected. Generally, for samples with a given grandparental country of birth, STRUCTURE assignment values to Northern, Southern, African and Asian clusters agreed with mitochondrial DNA and Y-chromosomal data from previous studies as well as historical records of migration and intermarriage. PMID:20546593

Effects of intravitreal insulin and insulin signaling cascade inhibitors on emmetropization in the chick

PubMed Central

Penha, Alexandra Marcha; Burkhardt, Eva; Schaeffel, Frank

2012-01-01

Purpose Intravitreal insulin has been shown to be a powerful stimulator of myopia in chickens, in particular if the retinal image is degraded or defocused. In most tissues, the insulin receptor activates two main signaling pathways: a) the mitogen-activated protein kinase (MAPK) cascade (e.g., mitogen-activated protein kinasem kinase [MEK] and extracellular regulated kinase [ERK]) and b) the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. In the current study, insulin was injected, and these pathways were separately inhibited to determine which is activated when the retinal image is defocused by spectacle lenses. Methods Chicks were treated with either +7 D, −7 D, or no lenses. They were intravitreally injected with insulin, the MEK inhibitor U0126, the PI3K inhibitor Ly294002, or a combination of insulin and one of the inhibitors. Refractions and ocular dimension were measured at the beginning and after four days of treatment. The retinal proteins of the chicks were measured with western blots after 2 h and four days of treatment. Incubation occurred with anti-Akt1, anti-Erk1/2, anti-phospho-AktThr308, and anti-phospho-Erk1/2(Thr202/Tyr204) antibodies, and the ratio between the relative intensity of the phospho-form and the total-form was calculated. Results Chicks wearing positive lenses and injected with saline and with PI3K inhibitor compensated for the imposed defocus and became hyperopic. Insulin injections and insulin plus PI3K inhibitor injections prevented lens-induced hyperopia, whereas the MEK inhibitor alone and insulin plus MEK inhibitor had no effect. Obviously, the MEK inhibitor suppressed the effect of insulin on eye growth in the plus lens–treated animals. Chicks treated with negative lenses and injected with insulin, or with insulin plus MEK inhibitor, overcompensated for the imposed defocus. This effect of insulin was not detected in eyes injected with PI3K inhibitor plus insulin, suggesting that the PI3K inhibitor suppressed the effects of insulin in minus lens–treated animals. Insulin increased the ratio of phospho-Akt/total-Akt in animals with normal visual exposure but even more so in chicks wearing plus or minus lenses. The increase was blocked by simultaneous PI3K inhibitor injections in control eyes but not in lens-treated eyes. Insulin also increased the ratio of phospho-ERK/total-ERK in animals with normal visual exposure and in animals wearing positive lenses, compared to U0126- and Ly294002-injected eyes. In contrast, no significant activation of the MEK/ERK pathway was observed in the negative lens–treated animals. Conclusions Intravitreal insulin promoted axial eye growth and stimulated both signaling pathways. The PI3K/Akt pathway was activated in control and plus and minus lens–treated eyes, but the MEK/ERK pathway was activated only with positive lenses or no lenses. With negative lenses, insulin did not stimulate the MEK/ERK signaling cascade. Independent of the pathway stimulated after insulin binding, the effect on insulin was always the same: an increase in eye growth. PMID:23112573

Effects of intravitreal insulin and insulin signaling cascade inhibitors on emmetropization in the chick.

PubMed

Penha, Alexandra Marcha; Burkhardt, Eva; Schaeffel, Frank; Feldkaemper, Marita P

2012-01-01

Intravitreal insulin has been shown to be a powerful stimulator of myopia in chickens, in particular if the retinal image is degraded or defocused. In most tissues, the insulin receptor activates two main signaling pathways: a) the mitogen-activated protein kinase (MAPK) cascade (e.g., mitogen-activated protein kinasem kinase [MEK] and extracellular regulated kinase [ERK]) and b) the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. In the current study, insulin was injected, and these pathways were separately inhibited to determine which is activated when the retinal image is defocused by spectacle lenses. Chicks were treated with either +7 D, -7 D, or no lenses. They were intravitreally injected with insulin, the MEK inhibitor U0126, the PI3K inhibitor Ly294002, or a combination of insulin and one of the inhibitors. Refractions and ocular dimension were measured at the beginning and after four days of treatment. The retinal proteins of the chicks were measured with western blots after 2 h and four days of treatment. Incubation occurred with anti-Akt1, anti-Erk1/2, anti-phospho-Akt(Thr308), and anti-phospho-Erk1/2((Thr202/Tyr204)) antibodies, and the ratio between the relative intensity of the phospho-form and the total-form was calculated. Chicks wearing positive lenses and injected with saline and with PI3K inhibitor compensated for the imposed defocus and became hyperopic. Insulin injections and insulin plus PI3K inhibitor injections prevented lens-induced hyperopia, whereas the MEK inhibitor alone and insulin plus MEK inhibitor had no effect. Obviously, the MEK inhibitor suppressed the effect of insulin on eye growth in the plus lens-treated animals. Chicks treated with negative lenses and injected with insulin, or with insulin plus MEK inhibitor, overcompensated for the imposed defocus. This effect of insulin was not detected in eyes injected with PI3K inhibitor plus insulin, suggesting that the PI3K inhibitor suppressed the effects of insulin in minus lens-treated animals. Insulin increased the ratio of phospho-Akt/total-Akt in animals with normal visual exposure but even more so in chicks wearing plus or minus lenses. The increase was blocked by simultaneous PI3K inhibitor injections in control eyes but not in lens-treated eyes. Insulin also increased the ratio of phospho-ERK/total-ERK in animals with normal visual exposure and in animals wearing positive lenses, compared to U0126- and Ly294002-injected eyes. In contrast, no significant activation of the MEK/ERK pathway was observed in the negative lens-treated animals. Intravitreal insulin promoted axial eye growth and stimulated both signaling pathways. The PI3K/Akt pathway was activated in control and plus and minus lens-treated eyes, but the MEK/ERK pathway was activated only with positive lenses or no lenses. With negative lenses, insulin did not stimulate the MEK/ERK signaling cascade. Independent of the pathway stimulated after insulin binding, the effect on insulin was always the same: an increase in eye growth.

The effect of variably tinted spectacle lenses on visual performance in cataract subjects.

PubMed

Naidu, Srilata; Lee, Jason E; Holopigian, Karen; Seiple, William H; Greenstein, Vivienne C; Stenson, Susan M

2003-01-01

A body of clinical and laboratory evidence suggests that tinted spectacle lenses may have an effect on visual performance. The aim of this study was to quantify the effects of spectacle lens tint on the visual performance of 25 subjects with cataracts. Cataracts were scored based on best-corrected acuity and by comparison with the Lens Opacity Classification System (LOCS III) plates. Visual performance was assessed by measuring contrast sensitivity with and without glare (Morphonome software version 4.0). The effect of gray, brown, yellow, green and purple tinting was evaluated. All subjects demonstrated an increase in contrast thresholds under glare conditions regardless of lens tint. However, brown and yellow lens tints resulted in the least amount of contrast threshold increase. Gray lens tint resulted in the largest contrast threshold increase. Individuals with lenticular changes may benefit from brown or yellow spectacle lenses under glare conditions.

Tunable liquid microlens array driven by pyroelectric effect: full interferometric characterization

NASA Astrophysics Data System (ADS)

Miccio, Lisa; Grilli, Simonetta; Vespini, Veronica; Ferraro, Pietro

2008-09-01

Liquid lenses with adjustable focal length are of great interest in the field of microfluidic devices. They are, usually, realized by electrowetting effect after electrodes patterning on a hydrofobic substrate. Applications are possible in many fields ranging from commercial products such as digital cameras to biological cell sorting. We realized an open array of liquid lenses with adjustable focal length without electrode patterning. We used a z-cut Lithium Niobate crystal (LN) as substrate and few microliters of an oily substance to obtain the droplets array. The spontaneous polarization of LN crystals is reversed by the electric field poling process, thus enabling the realization of periodically poled LN (PPLN) crystals. The substrate consists of a two-dimensional square array of reversed domains with a period around 200 μm. Each domain presents an hexagonal geometry due to the crystal structure. PPLN is first covered by a thin and homogeneous layer of the above mentioned liquid and therefore its temperature is changed by means of a digitally controlled hot plate. During heating and cooling process there is a rearrangement of the liquid layer until it reaches the final topography. Lenses formation is due to the superficial tension changing at the liquid-solid interface by means of the pyroelectric effect. Such effect allows to create a two-dimensional lens pattern of tunable focal length without electrodes. The temporal evolution of both shape and focal length lenses are quantitatively measured by Digital Holographic Microscopy. Array imaging properties and quantitative analysis of the lenses features and aberrations are presented.

On the Contribution of Large-Scale Structure to Strong Gravitational Lensing

NASA Astrophysics Data System (ADS)

Faure, C.; Kneib, J.-P.; Hilbert, S.; Massey, R.; Covone, G.; Finoguenov, A.; Leauthaud, A.; Taylor, J. E.; Pires, S.; Scoville, N.; Koekemoer, Anton M.

2009-04-01

We study the correlation between the locations of galaxy-galaxy strong-lensing candidates and tracers of large-scale structure from both weak lensing (WL) or X-ray emission. The Cosmological Evolution Survey (COSMOS) is a unique data set, combining deep, high resolution and contiguous imaging in which strong lenses have been discovered, plus unparalleled multiwavelength coverage. To help interpret the COSMOS data, we have also produced mock COSMOS strong- and WL observations, based on ray-tracing through the Millennium Simulation. In agreement with the simulations, we find that strongly lensed images with the largest angular separations are found in the densest regions of the COSMOS field. This is explained by a prevalence among the lens population in dense environments of elliptical galaxies with high total-to-stellar mass ratios, which can deflect light through larger angles. However, we also find that the overall fraction of elliptical galaxies with strong gravitational lensing is independent of the local mass density; this observation is not true of the simulations, which predict an increasing fraction of strong lenses in dense environments. The discrepancy may be a real effect, but could also be explained by various limitations of our analysis. For example, our visual search of strong lens systems could be incomplete and suffer from selection bias; the luminosity function of elliptical galaxies may differ between our real and simulated data; or the simplifying assumptions and approximations used in our lensing simulations may be inadequate. Work is therefore ongoing. Automated searches for strong lens systems will be particularly important in better constraining the selection function.

Protection of reinforced concrete bridge substructures using submerged bulk anodes : final report, January 25, 2009.

DOT National Transportation Integrated Search

2010-01-01

Reinforced concrete bridge substructures in Florida coastal waters have historically experienced deterioration as a consequence of embedded steel corrosion and resultant concrete cracking and spalling. Ultimately, this deterioration leads to added ma...

8. View of substructure showing the lower chord of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. View of substructure showing the lower chord of the Howe truss, flared board-and-batten siding, and pier configuration - Drift Creek Bridge, Spanning Drift Creek on Drift Creek County Road, Lincoln City, Lincoln County, OR

Development of a precast bent cap system

DOT National Transportation Integrated Search

2001-01-01

Improved speed of construction and economy can be achieved through the use of precast bridge substructures. As a step in the advancement of precast bridge substructures, a precast bent cap system is developed for nonseismic regions, including a desig...

Analysis of the state of the art of precast concrete bridge substructure systems.

DOT National Transportation Integrated Search

2013-10-01

Precasting of bridge substructure components holds potential for accelerating the construction of bridges,reducing : impacts to the traveling public on routes adjacent to construction sites, improving bridge durability and hence service : life, and r...

Modeling of rail track substructure linear elastic coupling

DOT National Transportation Integrated Search

2015-09-30

Most analyses of rail dynamics neglect contribution of the soil, or treat it in a very simple manner such as using spring elements. This can cause accuracy issues in examining dynamics for passenger comfort, derailment, substructure analysis, or othe...

Substructure detail view of the castinplace concrete bents and steel, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Substructure detail view of the cast-in-place concrete bents and steel, longitudinal "I" beams. - Marion Creek Bridge, Spanning Marion Creek at Milepoint 66.42 on North Santiam Highway (OR-22), Marion Forks, Linn County, OR

2. VIEW OF NORTH FACE SHOWING SUBSTRUCTURE AND ABUTMENTS OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. VIEW OF NORTH FACE SHOWING SUBSTRUCTURE AND ABUTMENTS OF BRIDGE CROSSING THE SOUTH FORK OF THE TUOLUMNE RIVER. - South Fork Tuolumne River Bridge, Spanning South Fork Tuolumne River on Tioga Road, Mather, Tuolumne County, CA

Sub-wavelength Laser Nanopatterning using Droplet Lenses

NASA Astrophysics Data System (ADS)

Duocastella, Martí; Florian, Camilo; Serra, Pere; Diaspro, Alberto

2015-11-01

When a drop of liquid falls onto a screen, e.g. a cell phone, the pixels lying underneath appear magnified. This lensing effect is a combination of the curvature and refractive index of the liquid droplet. Here, the spontaneous formation of such lenses is exploited to overcome the diffraction limit of a conventional laser direct-writing system. In particular, micro-droplets are first laser-printed at user-defined locations on a surface and they are later used as lenses to focus the same laser beam. Under conditions described herein, nanopatterns can be obtained with a reduction in spot size primarily limited by the refractive index of the liquid. This all-optics approach is demonstrated by writing arbitrary patterns with a feature size around 280 nm, about one fourth of the processing wavelength.

Types of Contact Lenses

MedlinePlus

... Consumer Devices Consumer Products Contact Lenses Types of Contact Lenses Share Tweet Linkedin Pin it More sharing ... Orthokeratology (Ortho-K) Decorative (Plano) Contact Lenses Soft Contact Lenses Soft contact lenses are made of soft, ...

Projection Effects of Large-scale Structures on Weak-lensing Peak Abundances

NASA Astrophysics Data System (ADS)

Yuan, Shuo; Liu, Xiangkun; Pan, Chuzhong; Wang, Qiao; Fan, Zuhui

2018-04-01

High peaks in weak lensing (WL) maps originate dominantly from the lensing effects of single massive halos. Their abundance is therefore closely related to the halo mass function and thus a powerful cosmological probe. However, besides individual massive halos, large-scale structures (LSS) along lines of sight also contribute to the peak signals. In this paper, with ray-tracing simulations, we investigate the LSS projection effects. We show that for current surveys with a large shape noise, the stochastic LSS effects are subdominant. For future WL surveys with source galaxies having a median redshift z med ∼ 1 or higher, however, they are significant. For the cosmological constraints derived from observed WL high-peak counts, severe biases can occur if the LSS effects are not taken into account properly. We extend the model of Fan et al. by incorporating the LSS projection effects into the theoretical considerations. By comparing with simulation results, we demonstrate the good performance of the improved model and its applicability in cosmological studies.

Geodesic curve-of-sight formulae for the cosmic microwave background: a unified treatment of redshift, time delay, and lensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saito, Ryo; Naruko, Atsushi; Hiramatsu, Takashi

2014-10-01

In this paper, we introduce a new approach to a treatment of the gravitational effects (redshift, time delay and lensing) on the observed cosmic microwave background (CMB) anisotropies based on the Boltzmann equation. From the Liouville's theorem in curved spacetime, the intensity of photons is conserved along a photon geodesic when non-gravitational scatterings are absent. Motivated by this fact, we derive a second-order line-of-sight formula by integrating the Boltzmann equation along a perturbed geodesic (curve) instead of a background geodesic (line). In this approach, the separation of the gravitational and intrinsic effects are manifest. This approach can be considered asmore » a generalization of the remapping approach of CMB lensing, where all the gravitational effects can be treated on the same footing.« less

An Appraisal of the Irlen Technique of Correcting Reading Disorders Using Tinted Overlays and Tinted Lenses.

ERIC Educational Resources Information Center

Solan, Harold A.

1990-01-01

The article reviews three studies (EC 600 064-066) evaluating the effectiveness of using Irlen tinted lenses or overlays with reading-disabled persons. It is concluded that carefully designed and controlled studies do not currently lend support to the Irlen hypothesis. (DB)

Bias to CMB lensing reconstruction from temperature anisotropies due to large-scale galaxy motions

NASA Astrophysics Data System (ADS)

Ferraro, Simone; Hill, J. Colin

2018-01-01

Gravitational lensing of the cosmic microwave background (CMB) is expected to be amongst the most powerful cosmological tools for ongoing and upcoming CMB experiments. In this work, we investigate a bias to CMB lensing reconstruction from temperature anisotropies due to the kinematic Sunyaev-Zel'dovich (kSZ) effect, that is, the Doppler shift of CMB photons induced by Compton scattering off moving electrons. The kSZ signal yields biases due to both its own intrinsic non-Gaussianity and its nonzero cross-correlation with the CMB lensing field (and other fields that trace the large-scale structure). This kSZ-induced bias affects both the CMB lensing autopower spectrum and its cross-correlation with low-redshift tracers. Furthermore, it cannot be removed by multifrequency foreground separation techniques because the kSZ effect preserves the blackbody spectrum of the CMB. While statistically negligible for current data sets, we show that it will be important for upcoming surveys, and failure to account for it can lead to large biases in constraints on neutrino masses or the properties of dark energy. For a stage 4 CMB experiment, the bias can be as large as ≈15 % or 12% in cross-correlation with LSST galaxy lensing convergence or galaxy overdensity maps, respectively, when the maximum temperature multipole used in the reconstruction is ℓmax=4000 , and about half of that when ℓmax=3000 . Similarly, we find that the CMB lensing autopower spectrum can be biased by up to several percent. These biases are many times larger than the expected statistical errors. We validate our analytical predictions with cosmological simulations and present the first complete estimate of secondary-induced CMB lensing biases. The predicted bias is sensitive to the small-scale gas distribution, which is affected by pressure and feedback mechanisms, thus making removal via "bias-hardened" estimators challenging. Reducing ℓmax can significantly mitigate the bias at the cost of a decrease in the overall lensing reconstruction signal-to-noise. A bias ≲1 % on large scales requires ℓmax≲2000 , which leads to a reduction in signal-to-noise by a factor of ≈3 - 5 for a stage 4 CMB experiment. Polarization-only reconstruction may be the most robust mitigation strategy.

Bayesian comparison of protein structures using partial Procrustes distance.

PubMed

Ejlali, Nasim; Faghihi, Mohammad Reza; Sadeghi, Mehdi

2017-09-26

An important topic in bioinformatics is the protein structure alignment. Some statistical methods have been proposed for this problem, but most of them align two protein structures based on the global geometric information without considering the effect of neighbourhood in the structures. In this paper, we provide a Bayesian model to align protein structures, by considering the effect of both local and global geometric information of protein structures. Local geometric information is incorporated to the model through the partial Procrustes distance of small substructures. These substructures are composed of β-carbon atoms from the side chains. Parameters are estimated using a Markov chain Monte Carlo (MCMC) approach. We evaluate the performance of our model through some simulation studies. Furthermore, we apply our model to a real dataset and assess the accuracy and convergence rate. Results show that our model is much more efficient than previous approaches.

State-of-the-Art Report About Durability of Post-Tensioned Bridge Substructures

DOT National Transportation Integrated Search

1999-10-01

Durability design requires an understanding of the factors influencing durability and the measures necessary to improve durability of concrete structures. The objectives of this report are to: 1. Survey the condition of bridge substructures in Texas;...

Field validation of polyurethane technology in remediating rail substructure and enhancing rail freight capacity.

DOT National Transportation Integrated Search

2016-10-01

Railways are an important component of a multi-modal freight transport network. The structural integrity of rail substructure and problematic railway elements can be compromised leading to track instability and ultimately, train derailments. Because ...

Dynamical structure of extreme ultraviolet macrospicules

NASA Technical Reports Server (NTRS)

Karovska, Margarita; Habbal, Shadia Rifai

1994-01-01

We describe the substructures forming the macrospicules and their temporal evolution, as revealed by the application of an image enhancement algorithm to extreme ultraviolet (EUV) observations of macrospicules. The enhanced images uncover, for the first time, the substructures forming the column-like structures within the macrospicules and the low-lying arches at their base. The spatial and temporal evolution of macrospicules clearly show continuous interaction between these substructures with occasional ejection of plasma following a ballistic trajectory. We comment on the importance of these results for planning near future space observations of macrospicules with better temporal and spatial resolution.

System for detecting substructure microfractures and method therefore

NASA Technical Reports Server (NTRS)

Parthasarathy, S. P.; Narasimhan, K. Y. (Inventor)

1979-01-01

Bursts of signals at different frequencies are induced into substructure, adjacent to a borehole. The return signals from each burst of signals are normalized to compensate for the attenuation, experienced by more distant return signals. The peak amplitudes of return signals, above a selected level, are cut off, and an average signal is produced from the normalized amplitude-limited return signals of each burst. The averaged signals of the return signals of all the signal bursts at the different frequencies are processed to provide a combined signal, whose amplitude is related to the microfracture density of the substructure adjacent to the borehole.

Study of substructure of high transverse momentum jets produced in proton-antiproton collisions at √s=1.96 TeV

DOE PAGES

Aaltonen, T.; Alon, R.; Álvarez González, B.; ...

2012-05-03

A study of the substructure of jets with transverse momentum greater than 400 GeV/c produced in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV at the Fermilab Tevatron Collider and recorded by the CDF II detector is presented. The distributions of the jet mass, angularity, and planar flow are measured for the first time in a sample with an integrated luminosity of 5.95 fb⁻¹. The observed substructure for high mass jets is consistent with predictions from perturbative quantum chromodynamics.

MS2Analyzer: A Software for Small Molecule Substructure Annotations from Accurate Tandem Mass Spectra

PubMed Central

2015-01-01

Systematic analysis and interpretation of the large number of tandem mass spectra (MS/MS) obtained in metabolomics experiments is a bottleneck in discovery-driven research. MS/MS mass spectral libraries are small compared to all known small molecule structures and are often not freely available. MS2Analyzer was therefore developed to enable user-defined searches of thousands of spectra for mass spectral features such as neutral losses, m/z differences, and product and precursor ions from MS/MS spectra in MSP/MGF files. The software is freely available at http://fiehnlab.ucdavis.edu/projects/MS2Analyzer/. As the reference query set, 147 literature-reported neutral losses and their corresponding substructures were collected. This set was tested for accuracy of linking neutral loss analysis to substructure annotations using 19 329 accurate mass tandem mass spectra of structurally known compounds from the NIST11 MS/MS library. Validation studies showed that 92.1 ± 6.4% of 13 typical neutral losses such as acetylations, cysteine conjugates, or glycosylations are correct annotating the associated substructures, while the absence of mass spectra features does not necessarily imply the absence of such substructures. Use of this tool has been successfully demonstrated for complex lipids in microalgae. PMID:25263576

Inverse dynamic substructuring using the direct hybrid assembly in the frequency domain

NASA Astrophysics Data System (ADS)

D'Ambrogio, Walter; Fregolent, Annalisa

2014-04-01

The paper deals with the identification of the dynamic behaviour of a structural subsystem, starting from the known dynamic behaviour of both the coupled system and the remaining part of the structural system (residual subsystem). This topic is also known as decoupling problem, subsystem subtraction or inverse dynamic substructuring. Whenever it is necessary to combine numerical models (e.g. FEM) and test models (e.g. FRFs), one speaks of experimental dynamic substructuring. Substructure decoupling techniques can be classified as inverse coupling or direct decoupling techniques. In inverse coupling, the equations describing the coupling problem are rearranged to isolate the unknown substructure instead of the coupled structure. On the contrary, direct decoupling consists in adding to the coupled system a fictitious subsystem that is the negative of the residual subsystem. Starting from a reduced version of the 3-field formulation (dynamic equilibrium using FRFs, compatibility and equilibrium of interface forces), a direct hybrid assembly is developed by requiring that both compatibility and equilibrium conditions are satisfied exactly, either at coupling DoFs only, or at additional internal DoFs of the residual subsystem. Equilibrium and compatibility DoFs might not be the same: this generates the so-called non-collocated approach. The technique is applied using experimental data from an assembled system made by a plate and a rigid mass.

New angles on energy correlation functions

DOE PAGES

Moult, Ian; Necib, Lina; Thaler, Jesse

2016-12-29

Jet substructure observables, designed to identify specific features within jets, play an essential role at the Large Hadron Collider (LHC), both for searching for signals beyond the Standard Model and for testing QCD in extreme phase space regions. In this paper, we systematically study the structure of infrared and collinear safe substructure observables, defining a generalization of the energy correlation functions to probe n-particle correlations within a jet. These generalized correlators provide a flexible basis for constructing new substructure observables optimized for specific purposes. Focusing on three major targets of the jet substructure community — boosted top tagging, boosted W/Z/Hmore » tagging, and quark/gluon discrimination — we use power-counting techniques to identify three new series of powerful discriminants: M i, N i, and U i. The Mi series is designed for use on groomed jets, providing a novel example of observables with improved discrimination power after the removal of soft radiation. The N i series behave parametrically like the N -subjettiness ratio observables, but are defined without respect to subjet axes, exhibiting improved behavior in the unresolved limit. Finally, the U i series improves quark/gluon discrimination by using higher-point correlators to simultaneously probe multiple emissions within a jet. Taken together, these observables broaden the scope for jet substructure studies at the LHC.« less

New angles on energy correlation functions

NASA Astrophysics Data System (ADS)

Moult, Ian; Necib, Lina; Thaler, Jesse

2016-12-01

Jet substructure observables, designed to identify specific features within jets, play an essential role at the Large Hadron Collider (LHC), both for searching for signals beyond the Standard Model and for testing QCD in extreme phase space regions. In this paper, we systematically study the structure of infrared and collinear safe substructure observables, defining a generalization of the energy correlation functions to probe n-particle correlations within a jet. These generalized correlators provide a flexible basis for constructing new substructure observables optimized for specific purposes. Focusing on three major targets of the jet substructure community — boosted top tagging, boosted W/Z/H tagging, and quark/gluon discrimination — we use power-counting techniques to identify three new series of powerful discriminants: M i , N i , and U i . The M i series is designed for use on groomed jets, providing a novel example of observables with improved discrimination power after the removal of soft radiation. The N i series behave parametrically like the N -subjettiness ratio observables, but are defined without respect to subjet axes, exhibiting improved behavior in the unresolved limit. Finally, the U i series improves quark/gluon discrimination by using higher-point correlators to simultaneously probe multiple emissions within a jet. Taken together, these observables broaden the scope for jet substructure studies at the LHC.

Small-scale modification to the lensing kernel

NASA Astrophysics Data System (ADS)

Hadzhiyska, Boryana; Spergel, David; Dunkley, Joanna

2018-02-01

Calculations of the cosmic microwave background (CMB) lensing power implemented into the standard cosmological codes such as camb and class usually treat the surface of last scatter as an infinitely thin screen. However, since the CMB anisotropies are smoothed out on scales smaller than the diffusion length due to the effect of Silk damping, the photons which carry information about the small-scale density distribution come from slightly earlier times than the standard recombination time. The dominant effect is the scale dependence of the mean redshift associated with the fluctuations during recombination. We find that fluctuations at k =0.01 Mpc-1 come from a characteristic redshift of z ≈1090 , while fluctuations at k =0.3 Mpc-1 come from a characteristic redshift of z ≈1130 . We then estimate the corrections to the lensing kernel and the related power spectra due to this effect. We conclude that neglecting it would result in a deviation from the true value of the lensing kernel at the half percent level at small CMB scales. For an all-sky, noise-free experiment, this corresponds to a ˜0.1 σ shift in the observed temperature power spectrum on small scales (2500 ≲l ≲4000 ).

Mechanically triggered solute uptake in soft contact lenses.

PubMed

Tavazzi, Silvia; Ferraro, Lorenzo; Fagnola, Matteo; Cozza, Federica; Farris, Stefano; Bonetti, Simone; Simonutti, Roberto; Borghesi, Alessandro

2015-06-01

Molecular arrangement plays a role in the diffusion of water and solutes across soft contact lenses. In particular, the uptake of solutes in hydrated contact lenses can occur as long as free water is available for diffusion. In this work, we investigated the effect of mechanical vibrations of low frequency (200 Hz) on the solute uptake. Hyaluronan, a polysaccharide of ophthalmic use, was taken as example of solute of interest. For a specific water-hydrated hydrogel material, differential scanning calorimetry experiments showed that a large fraction of the hydration water accounted for loosely-bound water, both before and after one week of daily-wear of the lenses. The size (of the order of magnitude of few hundreds of nanometers) of hyaluronan in aqueous solution was found to be less than the size of the pores of the lens observed by scanning electron microscopy. However, solute uptake in already-hydrated lenses was negligible by simple immersion, while a significant increase occurred under mechanical vibrations of 200 Hz, thus providing experimental evidence of mechanically triggered enhanced solute uptake, which is attributed to the release of interfacial loosely-bound water. Also other materials were taken into consideration. However, the effectiveness of mechanical vibrations for hyaluronan uptake is restricted to lenses containing interfacial loosely-bound water. Indeed, loosely-bound water is expected to be bound to the polymer with bonding energies of the order of magnitude of 10-100 J/g, which are compatible with the energy input supplied by the vibrations. Copyright © 2015 Elsevier B.V. All rights reserved.

Detachment of trophozoites of Acanthamoeba species from soft contact lenses with BEN22 detergent, BioSoak, and Renu multi-purpose solutions.

PubMed

Raali, E; Vaahtoranta-Lehtonen, H H; Lehtonen, O P

2001-07-01

BEN22 detergent was studied for its ability to detach Acanthamoeba from soft contact lenses without mechanical cleaning or separate cleaning agents. Trophozoites of Acanthamoeba castellanii and A. polyphaga were adhered onto nonionic, high water content soft contact lenses. The lenses were immersed for 2 hours in contact lens care solutions and the remaining trophozoites were counted microscopically. The counts were compared to the counts on the same lens before treatment. BEN22 (50:50 mixture of L-alpha-L-rhamnopyranosyl-beta-hydroxydecanoyl-beta-hydroxydecanoate and 2-O-alpha-L-rhamnopyranosyl-alpha-L-rhamnopyranosyl-beta-hydroxydecanoyl-beta-hydroxydecanoate) (Kassell Industries, Inc., Wisconsin Dells, WI) in a concentration of 0.05% detached the trophozoites to a statistically significant greater extent than saline, but commercial ReNu Multi-Purpose Solution (Bausch & Lomb, Italy) and BioSoak (Finnsusp Ltd., Finland) did so as well. ReNu Multi-Purpose Solution was more effective than 0.005% BEN22 in detaching the trophozoites of both of the Acanthamoeba strains. After the 2 hour immersion period, a maximum of 97% of the initial trophozoites were detached. The variation between individual lenses was significantly greater than that within the different areas of one lens. BEN22 had no reliable detaching effect on Acanthamoeba. The variation between lenses was great, and the rate of detachment was low with all the agents tested indicating that immersion and rinsing in the solutions tested cannot be considered as a safe substitute for proper disinfection against Acanthamoeba in contact lens care.

Looking through the same lens: Shear calibration for LSST, Euclid, and WFIRST with stage 4 CMB lensing

NASA Astrophysics Data System (ADS)

Schaan, Emmanuel; Krause, Elisabeth; Eifler, Tim; Doré, Olivier; Miyatake, Hironao; Rhodes, Jason; Spergel, David N.

2017-06-01

The next-generation weak lensing surveys (i.e., LSST, Euclid, and WFIRST) will require exquisite control over systematic effects. In this paper, we address shear calibration and present the most realistic forecast to date for LSST/Euclid/WFIRST and CMB lensing from a stage 4 CMB experiment ("CMB S4"). We use the cosmolike code to simulate a joint analysis of all the two-point functions of galaxy density, galaxy shear, and CMB lensing convergence. We include the full Gaussian and non-Gaussian covariances and explore the resulting joint likelihood with Monte Carlo Markov chains. We constrain shear calibration biases while simultaneously varying cosmological parameters, galaxy biases, and photometric redshift uncertainties. We find that CMB lensing from CMB S4 enables the calibration of the shear biases down to 0.2%-3% in ten tomographic bins for LSST (below the ˜0.5 % requirements in most tomographic bins), down to 0.4%-2.4% in ten bins for Euclid, and 0.6%-3.2% in ten bins for WFIRST. For a given lensing survey, the method works best at high redshift where shear calibration is otherwise most challenging. This self-calibration is robust to Gaussian photometric redshift uncertainties and to a reasonable level of intrinsic alignment. It is also robust to changes in the beam and the effectiveness of the component separation of the CMB experiment, and slowly dependent on its depth, making it possible with third-generation CMB experiments such as AdvACT and SPT-3G, as well as the Simons Observatory.

Computational Simulation of Continuous Fiber-Reinforced Ceramic Matrix Composites Behavior

NASA Technical Reports Server (NTRS)

Murthy, Pappu L. N.; Chamis, Christos C.; Mital, Subodh K.

1996-01-01

This report describes a methodology which predicts the behavior of ceramic matrix composites and has been incorporated in the computational tool CEMCAN (CEramic Matrix Composite ANalyzer). The approach combines micromechanics with a unique fiber substructuring concept. In this new concept, the conventional unit cell (the smallest representative volume element of the composite) of the micromechanics approach is modified by substructuring it into several slices and developing the micromechanics-based equations at the slice level. The methodology also takes into account nonlinear ceramic matrix composite (CMC) behavior due to temperature and the fracture initiation and progression. Important features of the approach and its effectiveness are described by using selected examples. Comparisons of predictions and limited experimental data are also provided.

Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear

PubMed Central

Behar-Cohen, Francine; Baillet, Gilles; de Ayguavives, Tito; Garcia, Paula Ortega; Krutmann, Jean; Peña-García, Pablo; Reme, Charlotte; Wolffsohn, James S

2014-01-01

Ultraviolet (UV) radiation potentially damages the skin, the immune system, and structures of the eye. A useful UV sun protection for the skin has been established. Since a remarkable body of evidence shows an association between UV radiation and damage to structures of the eye, eye protection is important, but a reliable and practical tool to assess and compare the UV-protective properties of lenses has been lacking. Among the general lay public, misconceptions on eye-sun protection have been identified. For example, sun protection is mainly ascribed to sunglasses, but less so to clear lenses. Skin malignancies in the periorbital region are frequent, but usual topical skin protection does not include the lids. Recent research utilized exact dosimetry and demonstrated relevant differences in UV burden to the eye and skin at a given ambient irradiation. Chronic UV effects on the cornea and lens are cumulative, so effective UV protection of the eyes is important for all age groups and should be used systematically. Protection of children’s eyes is especially important, because UV transmittance is higher at a very young age, allowing higher levels of UV radiation to reach the crystalline lens and even the retina. Sunglasses as well as clear lenses (plano and prescription) effectively reduce transmittance of UV radiation. However, an important share of the UV burden to the eye is explained by back reflection of radiation from lenses to the eye. UV radiation incident from an angle of 135°–150° behind a lens wearer is reflected from the back side of lenses. The usual antireflective coatings considerably increase reflection of UV radiation. To provide reliable labeling of the protective potential of lenses, an eye-sun protection factor (E-SPF®) has been developed. It integrates UV transmission as well as UV reflectance of lenses. The E-SPF® compares well with established skin-sun protection factors and provides clear messages to eye health care providers and to lay consumers. PMID:24379652

Effect of plasma treatment on the performance of two drug-loaded hydrogel formulations for therapeutic contact lenses.

PubMed

Paradiso, Patrizia; Chu, Virginia; Santos, Luís; Serro, Ana Paula; Colaço, Rogério; Saramago, Benilde

2015-07-01

Although the plasma technology has long been applied to treat contact lenses, the effect of this treatment on the performance of drug-loaded contact lenses is still unclear. The objective of this work is to study the effect of nitrogen plasma treatment on two drug-loaded polymeric formulations which previously demonstrated to be suitable for therapeutic contact lenses: a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel loaded with levofloxacin and a silicone-based hydrogel loaded with chlorhexidine. Modifications of the surface and the optical properties, and alterations in the drug release profiles and possible losses of the antimicrobial activities of the drugs induced by the plasma treatment were assessed. The results showed that, depending on the system and on the processing conditions, the plasma treatment may be beneficial for increasing wettability and refractive index, without degrading the lens surface. From the point of view of drug delivery, plasma irradiation at moderate power (200 W) decreased the initial release rate and the amount of released drug, maintaining the drug activity. For lower (100 W) and higher powers (300 W), almost no effect was detected because the treatment was, respectively, too soft and too aggressive for the lens materials. © 2014 Wiley Periodicals, Inc.

Development of a 2 MHz Sonar Sensor for Inspection of Bridge Substructures.

PubMed

Park, Chul; Kim, Youngseok; Lee, Heungsu; Choi, Sangsik; Jung, Haewook

2018-04-16

Hydraulic factors account for a large part of the causes of bridge collapse. Due to the nature of the underwater environment, quick and accurate inspection is required when damage occurs. In this study, we developed a 2 MHz side scan sonar sensor module and effective operation technique by improving the limitations of existing sonar. Through field tests, we analyzed the correlation of factors affecting the resolution of the sonar data such as the angle of survey, the distance from the underwater structure and the water depth. The effect of the distance and the water depth and the structure on the survey angle was 66~82%. We also derived the relationship between these factors as a regression model for effective operating techniques. It is considered that application of the developed 2 MHz side scan sonar and its operation method could contribute to prevention of bridge collapses and disasters by quickly and accurately checking the damage of bridge substructures due to hydraulic factors.

Development of a 2 MHz Sonar Sensor for Inspection of Bridge Substructures

PubMed Central

Park, Chul; Lee, Heungsu; Choi, Sangsik; Jung, Haewook

2018-01-01

Hydraulic factors account for a large part of the causes of bridge collapse. Due to the nature of the underwater environment, quick and accurate inspection is required when damage occurs. In this study, we developed a 2 MHz side scan sonar sensor module and effective operation technique by improving the limitations of existing sonar. Through field tests, we analyzed the correlation of factors affecting the resolution of the sonar data such as the angle of survey, the distance from the underwater structure and the water depth. The effect of the distance and the water depth and the structure on the survey angle was 66~82%. We also derived the relationship between these factors as a regression model for effective operating techniques. It is considered that application of the developed 2 MHz side scan sonar and its operation method could contribute to prevention of bridge collapses and disasters by quickly and accurately checking the damage of bridge substructures due to hydraulic factors. PMID:29659557

Contrast sensitivity of wildtype mice wearing diffusers or spectacle lenses, and the effect of atropine.

PubMed

Schmucker, Christine; Schaeffel, Frank

2006-03-01

To find out how spatial vision in mice is affected by wearing of spectacle lenses or diffusers, and by atropine eye drops. This information is necessary to determine which treatments could effectively induce refractive errors in young mice. Whole-body optomotor responses were recorded by automated video analysis in freely ranging mice in a large rotating drum that was covered inside with vertical square-wave gratings with spatial frequencies of 0.03, 0.10 and 0.30 cyc/deg, both at "dim light" (0.10 cd/m(2)), and under photopic conditions (30 cd/m(2)). Contrast thresholds were determined by varying the contrasts of the gratings. Mice wore either no lenses, or binocular plano lenses, or lenses with powers ranging from +25 D to -25 D, or diffusers. In another experiment, contrast thresholds were determined 30 min after binocular installation of one drop of 1% atropine solution which is known to suppress myopia development in other animal models. The range of spatial frequencies, at which the mice still responded to stripes with less than the maximal grating contrast, was rather small. At 0.03 cyc/deg, the mice responded to stripes with low contrast down to 24%. At 0.10 cyc/deg, the minimal contrast was 45%, but at 0.30 cyc/deg, only the maximum contrast elicited a significant response. In dim light, spatial vision was severely impaired and only the lowest spatial frequencies, presented at the highest contrast (91%), were detected. The whole-body optomotor response was largest with spectacle lens powers of plano diopters and +7D lenses. The magnitude of the response decreased symmetrically with increasing lens powers for both signs, providing information on the behavioral depth of field (a second-order fit through the data placed the extreme limits of a response at around +25 D and -25 D lens powers). Finally, atropine improved contrast sensitivity, at least at the lowest spatial frequency tested, a result that was previously obtained also in the chicken and could help to explain the inhibitory effect of atropine on myopia. The study shows that mice have sufficient spatial vision to respond to treatment with powerful spectacle lenses or diffusers. Accordingly, these devices should be effective in inducing refractive errors in this animal model, although primarily under photopic conditions.

Sensitivity of jet substructure to jet-induced medium response

NASA Astrophysics Data System (ADS)

Milhano, Guilherme; Wiedemann, Urs Achim; Zapp, Korinna Christine

2018-04-01

Jet quenching in heavy ion collisions is expected to be accompanied by recoil effects, but unambiguous signals for the induced medium response have been difficult to identify so far. Here, we argue that modern jet substructure measurements can improve this situation qualitatively since they are sensitive to the momentum distribution inside the jet. We show that the groomed subjet shared momentum fraction zg, and the girth of leading and subleading subjets signal recoil effects with dependencies that are absent in a recoilless baseline. We find that recoil effects can explain most of the medium modifications to the zg distribution observed in data. Furthermore, for jets passing the Soft Drop Condition, recoil effects induce in the differential distribution of subjet separation ΔR12 a characteristic increase with ΔR12, and they introduce a characteristic enhancement of the girth of the subleading subjet with decreasing zg. We explain why these qualitatively novel features, that we establish in JEWEL+PYTHIA simulations, reflect generic physical properties of recoil effects that should therefore be searched for as telltale signatures of jet-induced medium response.

Modeling of connections between substructures

NASA Technical Reports Server (NTRS)

Butler, Thomas G.

1991-01-01

It is demonstrated here that complete checkout of a basic substructure can be done under the special circumstance of a sliding connection with offsets. Stiff bar connectors make this possible so long as the bar coordinates are aligned with the displacement coordinates at the sliding surface.

FHWA LTBP Workshop to Identify Bridge Substructure Performance Issues

DOT National Transportation Integrated Search

2013-06-01

This TechBrief provides an overview of the proceedings and findings of the "FHWA Workshop to Identify Bridge Substructure Performance Issues" held in Orlando, Florida, from March 4 to 6, 2010. The purpose of the workshop was to consider overall bridg...

Detail view of substructure, view looking south at the center ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view of substructure, view looking south at the center in-water frame bent - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

Adhesion of Pseudomonas aeruginosa to orthokeratology and alignment lenses.

PubMed

Choo, Jennifer D; Holden, Brien A; Papas, Eric B; Willcox, Mark D P

2009-02-01

To determine whether contact lenses designed for orthokeratology (OK) are colonized by greater numbers of bacteria compared with standard (alignment fitted) design rigid gas permeable lenses before and after lens wear. Eighteen 1-year-old cats were randomly fitted with an OK lens in one eye and an alignment fitted (AF) lens in the other eye. Both lenses were made in the same diameter and central thickness and of the same material. Two separate wearing periods of 2 weeks and 6 weeks were used. After each wearing period, lenses were soaked in Pseudomonas aeruginosa (6294 or 6206) for 10 min. The lenses were then reinserted onto their respective corneas for a wearing period of 16 hours after which lenses were collected and remaining adhered bacteria quantified. Unworn control lenses were also soaked and bacteria enumerated for comparison. There were no significant differences in the number of bacteria adherent to unworn AF and OK lenses. Analysis of lenses after wear showed OK lenses retained significantly higher numbers of viable bacteria than AF lenses in all studies. OK lenses retain more bacteria than AF rigid gas permeable lenses after bacteria-loaded overnight lens wear. This may increase the risk for an infection in OK patients should suitable conditions be present. Specific education on the cleaning of OK lenses is essential.

Social-group identity and population substructure in admixed populations in New Mexico and Latin America.

PubMed

Healy, Meghan E; Hill, Deirdre; Berwick, Marianne; Edgar, Heather; Gross, Jessica; Hunley, Keith

2017-01-01

We examined the relationship between continental-level genetic ancestry and racial and ethnic identity in an admixed population in New Mexico with the goal of increasing our understanding of how racial and ethnic identity influence genetic substructure in admixed populations. Our sample consists of 98 New Mexicans who self-identified as Hispanic or Latino (NM-HL) and who further categorized themselves by race and ethnic subgroup membership. The genetic data consist of 270 newly-published autosomal microsatellites from the NM-HL sample and previously published data from 57 globally distributed populations, including 13 admixed samples from Central and South America. For these data, we 1) summarized the major axes of genetic variation using principal component analyses, 2) performed tests of Hardy Weinberg equilibrium, 3) compared empirical genetic ancestry distributions to those predicted under a model of admixture that lacked substructure, 4) tested the hypotheses that individuals in each sample had 100%, 0%, and the sample-mean percentage of African, European, and Native American ancestry. We found that most NM-HL identify themselves and their parents as belonging to one of two groups, conforming to a region-specific narrative that distinguishes recent immigrants from Mexico from individuals whose families have resided in New Mexico for generations and who emphasize their Spanish heritage. The "Spanish" group had significantly lower Native American ancestry and higher European ancestry than the "Mexican" group. Positive FIS values, PCA plots, and heterogeneous ancestry distributions suggest that most Central and South America admixed samples also contain substructure, and that this substructure may be related to variation in social identity. Genetic substructure appears to be common in admixed populations in the Americas and may confound attempts to identify disease-causing genes and to understand the social causes of variation in health outcomes and social inequality.

Evolution of the BCG in Disturbed Galaxy Clusters

NASA Astrophysics Data System (ADS)

Ardila, Felipe; Strauss, Michael A.; Lauer, Tod R.; Postman, Marc

2017-01-01

The present paradigm in cosmology tells us that large-scale structures grow hierarchically. This suggests that galaxy clusters grow by accreting mass and merging with other clusters, a process which should be detectable by the presence of substructure within a cluster. Using the Dressler-Shectman (DS) three-dimensional test for dynamical substructure, we determined which clusters showed evidence for disturbance from a set of 227 Abell clusters from Lauer et al. (2014) with at least 50 member galaxies and spectroscopic redshifts, z < 0.08. Our results show that 155 (68.2%) of the clusters showed evidence for substructure at ≥ 95% confidence, while 72 did not. Kolmogorov-Smirnov tests suggest that the two populations of clusters (those with and without detected substructure) are significantly different in their distributions of BCG luminosities (Lm), but not in their BCG stellar velocity dispersions (σ), their BCG spatial offsets from the x-ray centers of the clusters, their BCG velocity offsets from the mean cluster velocity, the logarithmic slopes of their BCG photometric curves of growth (α), their cluster velocity dispersions, or their luminosity differences between the BCG and the second-ranked galaxy in the cluster (M2). Similarly, no significant difference was found in the fitting of the Lm-α-σ metric plane for BCGs of clusters with substructure compared those in which there is not substructure. This is surprising since our hierarchical growth models suggest that some of these BCG/cluster properties would be affected by a disturbance of the cluster, indicating that our understanding of how BCGs evolve with their clusters is incomplete and we should explore other ways to probe the level of disturbance.

Under the sword of Damocles: plausible regeneration of dark matter cusps at the smallest galactic scales

NASA Astrophysics Data System (ADS)

Laporte, Chervin F. P.; Peñarrubia, Jorge

2015-04-01

We study the evolution of the dark matter (DM) halo profiles of dwarf galaxies driven by the accretion of DM substructures through controlled N-body experiments. Our initial conditions assume that early supernova feedback erases the primordial DM cusps of haloes with z = 0 masses of 109 - 1010 M⊙. The orbits and masses of the infalling substructures are borrowed from the Aquarius cosmological simulations. Our experiments show that a fraction of haloes that undergo 1:3 down to 1:30 mergers are susceptible to reform a DM cusp by z ≈ 0. Cusp regrowth is driven by the accretion of DM substructures that are dense enough to reach the central regions of the main halo before being tidally disrupted. The infall of substructures on the mean of the reported mass-concentration relation and a mass ratio above 1:6 systematically leads to cusp regrowth. Substructures with 1:6-1:8, and 1:8-1:30 only reform DM cusps if their densities are 1σ and 2σ above the mean, respectively. The merging time-scales of these dense, low-mass substructures is relatively long (5 - 11 Gyr), which may pose a time-scale problem for the longevity of DM cores in dwarfs galaxies and possibly explain the existence of dense dwarfs-like Draco. These results suggest that within cold dark matter a non-negligible level of scatter in the mass profiles of galactic haloes acted on by feedback is to be expected given the stochastic mass accretion histories of low-mass haloes and the diverse star formation histories observed in the Local Group dwarfs.

The Next Generation Virgo Cluster Survey (NGVS). XXXII. A Search for Globular Cluster Substructures in the Virgo Galaxy Cluster Core

NASA Astrophysics Data System (ADS)

Powalka, Mathieu; Puzia, Thomas H.; Lançon, Ariane; Longobardi, Alessia; Peng, Eric W.; Duc, Pierre-Alain; Alamo-Martínez, Karla; Blakeslee, John P.; Côté, Patrick; Cuillandre, Jean-Charles; Durrell, Patrick; Eigenthaler, Paul; Ferrarese, Laura; Guhathakurta, Puragra; Gwyn, S. D. J.; Hudelot, Patrick; Liu, Chengze; Mei, Simona; Muñoz, Roberto P.; Roediger, Joel; Sánchez-Janssen, Rubén; Toloba, Elisa; Zhang, Hongxin

2018-03-01

Substructure in globular cluster (GC) populations around large galaxies is expected in galaxy formation scenarios that involve accretion or merger events, and it has been searched for using direct associations between GCs and structure in the diffuse galaxy light, or with GC kinematics. Here, we present a search for candidate substructures in the GC population around the Virgo cD galaxy M87 through the analysis of the spatial distribution of the GC colors. The study is based on a sample of ∼1800 bright GCs with high-quality u, g, r, i, z, K s photometry, selected to ensure a low contamination by foreground stars or background galaxies. The spectral energy distributions of the GCs are associated with formal estimates of age and metallicity, which are representative of its position in a 4D color space relative to standard single stellar population models. Dividing the sample into broad bins based on the relative formal ages, we observe inhomogeneities that reveal signatures of GC substructures. The most significant of these is a spatial overdensity of GCs with relatively young age labels, of diameter ∼0.°1 (∼30 kpc), located to the south of M87. The significance of this detection is larger than about 5σ after accounting for estimates of random and systematic errors. Surprisingly, no large Virgo galaxy is present in this area that could potentially host these GCs. But candidate substructures in the M87 halo with equally elusive hosts have been described based on kinematic studies in the past. The number of GC spectra available around M87 is currently insufficient to clarify the nature of the new candidate substructure.

The Peculiar Light Curve of J1415+1320: A Case Study in Extreme Scattering Events

NASA Astrophysics Data System (ADS)

Vedantham, H. K.; Readhead, A. C. S.; Hovatta, T.; Koopmans, L. V. E.; Pearson, T. J.; Blandford, R. D.; Gurwell, M. A.; Lähteenmäki, A.; Max-Moerbeck, W.; Pavlidou, V.; Ravi, V.; Reeves, R. A.; Richards, J. L.; Tornikoski, M.; Zensus, J. A.

2017-08-01

The radio light curve of J1415+1320 (PKS 1413+135) shows time-symmetric and recurring U-shaped features across the centimeter-wave and millimeter-wave bands. The symmetry of these features points to lensing by an intervening object as the cause. U-shaped events in radio light curves in the centimeter-wave band have previously been attributed to Extreme scattering events (ESE). ESEs are thought to be the result of lensing by compact plasma structures in the Galactic interstellar medium, but the precise nature of these plasma structures remains unknown. Since the strength of a plasma lens evolves with wavelength λ as {λ }2, the presence of correlated variations at over a wide wavelength range casts doubt on the canonical ESE interpretation for J1415+1320. In this paper, we critically examine the evidence for plasma lensing in J1415+1320. We compute limits on the lensing strength and the associated free-free opacity of the putative plasma lenses. We compare the observed and model ESE light curves, and also derive a lower limit on the lens distance based on the effects of parallax due to the Earth’s orbit around the Sun. We conclude that plasma lensing is not a viable interpretation for J1415+1320's light curves and that symmetric U-shaped features in the radio light curves of extragalactic sources do not present prima facie evidence for ESEs. The methodology presented here is generic enough to be applicable to any plasma-lensing candidate.

RCSLenS: The Red Cluster Sequence Lensing Survey

NASA Astrophysics Data System (ADS)

Hildebrandt, H.; Choi, A.; Heymans, C.; Blake, C.; Erben, T.; Miller, L.; Nakajima, R.; van Waerbeke, L.; Viola, M.; Buddendiek, A.; Harnois-Déraps, J.; Hojjati, A.; Joachimi, B.; Joudaki, S.; Kitching, T. D.; Wolf, C.; Gwyn, S.; Johnson, N.; Kuijken, K.; Sheikhbahaee, Z.; Tudorica, A.; Yee, H. K. C.

2016-11-01

We present the Red Cluster Sequence Lensing Survey (RCSLenS), an application of the methods developed for the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS) to the ˜785 deg2, multi-band imaging data of the Red-sequence Cluster Survey 2. This project represents the largest public, sub-arcsecond seeing, multi-band survey to date that is suited for weak gravitational lensing measurements. With a careful assessment of systematic errors in shape measurements and photometric redshifts, we extend the use of this data set to allow cross-correlation analyses between weak lensing observables and other data sets. We describe the imaging data, the data reduction, masking, multi-colour photometry, photometric redshifts, shape measurements, tests for systematic errors, and a blinding scheme to allow for more objective measurements. In total, we analyse 761 pointings with r-band coverage, which constitutes our lensing sample. Residual large-scale B-mode systematics prevent the use of this shear catalogue for cosmic shear science. The effective number density of lensing sources over an unmasked area of 571.7 deg2 and down to a magnitude limit of r ˜ 24.5 is 8.1 galaxies per arcmin2 (weighted: 5.5 arcmin-2) distributed over 14 patches on the sky. Photometric redshifts based on four-band griz data are available for 513 pointings covering an unmasked area of 383.5 deg2. We present weak lensing mass reconstructions of some example clusters as well as the full survey representing the largest areas that have been mapped in this way. All our data products are publicly available through Canadian Astronomy Data Centre at http://www.cadc-ccda.hia-iha.nrc-cnrc.gc.ca/en/community/rcslens/query.html in a format very similar to the CFHTLenS data release.

The Effect of Spectacle Lenses Containing Peripheral Defocus on Refractive Error and Horizontal Eye Shape in the Guinea Pig

PubMed Central

E. Bowrey, Hannah; Zeng, Guang; Y. Tse, Dennis; J. Leotta, Amelia; Wu, Yi; To, Chi-Ho; F. Wildsoet, Christine; McFadden, Sally A.

2017-01-01

Purpose It has been proposed that the peripheral retina, responding to local optical defocus, contributes to myopia and associated altered eye growth in humans. To test this hypothesis, we measured the changes in central (on-axis) and peripheral ocular dimensions in guinea pigs wearing a concentric bifocal spectacle lens design with power restricted to the periphery. Methods Five groups of guinea pigs (n = 83) wore either a unifocal (UF) spectacle lens (−4, 0, or +4 Diopters [D]), or a peripheral defocus (PF) spectacle lens that had a plano center (diameter of 5 mm) with either −4 or +4 D in the surround (−4/0 or +4/0 D). The overall optical diameter of all lenses was 12 mm. Lenses were worn over one eye from 8 to 18 days of age for negative and plano lenses, or from 8 to 22 days of age for positive lenses. Refractive error was measured centrally and 30° off-axis in the temporal and nasal retina. The shape of the eye was analyzed from images of sectioned eyes. Results Lenses of −4 D UF induced myopia, reflecting enhanced ocular elongation, which was centered on the optic nerve head and included the surrounding peripapillary zone (PPZ, 18° in diameter). Some ocular expansion, including within the PPZ, also was recorded with −4/0 and +4/0 D PF lenses while the +4 D UF lens inhibited rather than enhanced elongation, centrally and peripherally. Conclusions Peripheral defocus-induced ocular expansion encompasses the PPZ, irrespective of the sign of the inducing defocus. Understanding the underlying mechanism potentially has important implications for designing multifocal lenses for controlling myopia in humans and also potentially for understanding the link between myopia and glaucoma. PMID:28549092

Statistical and systematic errors in the measurement of weak-lensing Minkowski functionals: Application to the Canada-France-Hawaii Lensing Survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shirasaki, Masato; Yoshida, Naoki, E-mail: masato.shirasaki@utap.phys.s.u-tokyo.ac.jp

2014-05-01

The measurement of cosmic shear using weak gravitational lensing is a challenging task that involves a number of complicated procedures. We study in detail the systematic errors in the measurement of weak-lensing Minkowski Functionals (MFs). Specifically, we focus on systematics associated with galaxy shape measurements, photometric redshift errors, and shear calibration correction. We first generate mock weak-lensing catalogs that directly incorporate the actual observational characteristics of the Canada-France-Hawaii Lensing Survey (CFHTLenS). We then perform a Fisher analysis using the large set of mock catalogs for various cosmological models. We find that the statistical error associated with the observational effects degradesmore » the cosmological parameter constraints by a factor of a few. The Subaru Hyper Suprime-Cam (HSC) survey with a sky coverage of ∼1400 deg{sup 2} will constrain the dark energy equation of the state parameter with an error of Δw {sub 0} ∼ 0.25 by the lensing MFs alone, but biases induced by the systematics can be comparable to the 1σ error. We conclude that the lensing MFs are powerful statistics beyond the two-point statistics only if well-calibrated measurement of both the redshifts and the shapes of source galaxies is performed. Finally, we analyze the CFHTLenS data to explore the ability of the MFs to break degeneracies between a few cosmological parameters. Using a combined analysis of the MFs and the shear correlation function, we derive the matter density Ω{sub m0}=0.256±{sub 0.046}{sup 0.054}.« less

Compensation of head-on beam-beam induced resonance driving terms and tune spread in the Relativistic Heavy Ion Collider

DOE PAGES

Fischer, W.; Gu, X.; Drees, K. A.; ...

2017-09-13

A head-on beam-beam compensation scheme was implemented for operation in the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory [Phys. Rev. Lett. 115, 264801 (2015)]. The compensation consists of electron lenses for the reduction of the beam-beam induced tune spread, and a lattice for the minimization of beam-beam generated resonance driving terms. We describe the implementations of the lattice and electron lenses, and report on measurements of lattice properties and the effect of the electron lenses on the hadron beam.

Compensation of head-on beam-beam induced resonance driving terms and tune spread in the Relativistic Heavy Ion Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, W.; Gu, X.; Drees, K. A.

A head-on beam-beam compensation scheme was implemented for operation in the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory [Phys. Rev. Lett. 115, 264801 (2015)]. The compensation consists of electron lenses for the reduction of the beam-beam induced tune spread, and a lattice for the minimization of beam-beam generated resonance driving terms. We describe the implementations of the lattice and electron lenses, and report on measurements of lattice properties and the effect of the electron lenses on the hadron beam.

A Prototype Antifungal Contact Lens

PubMed Central

Ciolino, Joseph B.; Hudson, Sarah P.; Mobbs, Ashley N.; Hoare, Todd R.; Iwata, Naomi G.; Fink, Gerald R.

2011-01-01

Purpose. To design a contact lens to treat and prevent fungal ocular infections. Methods. Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in phosphate-buffered saline at 37°C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross sections of the pre- and postrelease contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy. Results. Econazole-eluting contact lenses provided extended antifungal activity against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens. Conclusions. An econazole-eluting contact lens could be used as a treatment for fungal ocular infections. PMID:21527380

From Reading Stones, Glasses and Contact Lenses to Intraocular Lenses & Ophthalmic Lasers--A Short Overview over the History of Visual Aids.

PubMed

Scholtz, Sibylle K; Auffarth, Gerd U

2012-01-01

Alhazen, ibn al-Haytham, (965 Basra - c. 1040 in Cairo) was a Muslim polymath who made significant contributions to the principles of optics, being the first to recognize the optical effect by transparent objects in the 11th century. His insights led to a fundamental revolution, enabling older presbyopic persons to read again. Today many more options are available to help visually impaired people correct their sight defects. This article will give an historical overview of the sight aids which are available today and will describe the very first beginnings of the development of the "reading stone" or "glasses". Further, it will also give a chronological overview of more modern techniques, e.g., intraocular lenses, contact lenses and the options of refractive surgery.

Intraocular lenses in age-related macular degeneration.

PubMed

Grzybowski, Andrzej; Wasinska-Borowiec, Weronika; Alio, Jorge L; Amat-Peral, Pedro; Tabernero, Juan

2017-09-01

The aim of this work is to review the lenses, assessing their advantages and disadvantages. We describe a total of seven types of intraocular lenses (IOLs) recommended for age-related macular degeneration (AMD). We used the PubMed web platform to search for implantable devices in various stages of AMD. We searched for both prospective and retrospective studies and also case reports. Clinical results in AMD patients have been described for a total of seven types of IOLs recommended for AMD: an implantable miniature telescope (IMT), IOL-VIP System, Lipshitz macular implant (LMI), sulcus-implanted Lipshitz macular implant, LMI-SI, Fresnel Prism Intraocular Lens, iolAMD and Scharioth Macula Lens. We conclude that to objectively ascertain the effectiveness and safety of these lenses, further independent clinical studies with longer follow-up data are necessary prior to the general use of these optical devices.

Dark Energy Survey Year 1 Results: Methodology and Projections for Joint Analysis of Galaxy Clustering, Galaxy Lensing, and CMB Lensing Two-point Functions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giannantonio, T.; et al.

Optical imaging surveys measure both the galaxy density and the gravitational lensing-induced shear fields across the sky. Recently, the Dark Energy Survey (DES) collaboration used a joint fit to two-point correlations between these observables to place tight constraints on cosmology (DES Collaboration et al. 2017). In this work, we develop the methodology to extend the DES Collaboration et al. (2017) analysis to include cross-correlations of the optical survey observables with gravitational lensing of the cosmic microwave background (CMB) as measured by the South Pole Telescope (SPT) and Planck. Using simulated analyses, we show how the resulting set of five two-pointmore » functions increases the robustness of the cosmological constraints to systematic errors in galaxy lensing shear calibration. Additionally, we show that contamination of the SPT+Planck CMB lensing map by the thermal Sunyaev-Zel'dovich effect is a potentially large source of systematic error for two-point function analyses, but show that it can be reduced to acceptable levels in our analysis by masking clusters of galaxies and imposing angular scale cuts on the two-point functions. The methodology developed here will be applied to the analysis of data from the DES, the SPT, and Planck in a companion work.« less

Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact lenses.

PubMed

White, Charles J; McBride, Matthew K; Pate, Kayla M; Tieppo, Arianna; Byrne, Mark E

2011-08-01

Symptoms of contact lenses induced dry eye (CLIDE) are typically treated through application of macromolecular re-wetting agents via eye drops. Therapeutic soft contact lenses can be formulated to alleviate CLIDE symptoms by slowly releasing comfort agent from the lens. In this paper, we present an extended wear silicone hydrogel contact lens with extended, controllable release of 120 kDa hydroxypropyl methylcellulose (HPMC) using a molecular imprinting strategy. A commercial silicone hydrogel lens was tailored to release approximately 1000 μg of HPMC over a period of up to 60 days in a constant manner at a rate of 16 μg/day under physiological flowrates, releasing over the entire range of continuous wear. Release rates could be significantly varied by the imprinting effect and functional monomer to template ratio (M/T) with M/T values 0, 0.2, 2.8, 3.4 corresponding to HPMC release durations of 10, 13, 23, and 53 days, respectively. Lenses had high optical quality and adequate mechanical properties for contact lens use. This work highlights the potential of imprinting in the design and engineering of silicone hydrogel lenses to release macromolecules for the duration of wear, which may lead to decreased CLIDE symptoms and more comfortable contact lenses. Copyright © 2011 Elsevier Ltd. All rights reserved.

Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses

PubMed Central

Omali, Negar Babaei; Subbaraman, Lakshman N.; Coles-Brennan, Chantal; Fadli, Zohra; Jones, Lyndon W.

2015-01-01

ABSTRACT Within a few minutes of wear, contact lenses become rapidly coated with a variety of tear film components, including proteins, lipids, and mucins. Tears have a rich and complex composition, allowing a wide range of interactions and competitive processes, with the first event observed at the interface between a contact lens and tear fluid being protein adsorption. Protein adsorption on hydrogel contact lenses is a complex process involving a variety of factors relating to both the protein in question and the lens material. Among tear proteins, lysozyme is a major protein that has both antibacterial and anti-inflammatory functions. Contact lens materials that have high ionicity and high water content have an increased affinity to accumulate lysozyme during wear, when compared with other soft lens materials, notably silicone hydrogel lenses. This review provides an overview of tear film proteins, with a specific focus on lysozyme, and examines various factors that influence protein deposition on contact lenses. In addition, the impact of lysozyme deposition on various ocular physiological responses and bacterial adhesion to lenses and the interaction of lysozyme with other tear proteins are reviewed. This comprehensive review suggests that deposition of lysozyme on contact lens materials may provide a number of beneficial effects during contact lens wear. PMID:26002002

Calibrating the Planck cluster mass scale with CLASH

NASA Astrophysics Data System (ADS)

Penna-Lima, M.; Bartlett, J. G.; Rozo, E.; Melin, J.-B.; Merten, J.; Evrard, A. E.; Postman, M.; Rykoff, E.

2017-08-01

We determine the mass scale of Planck galaxy clusters using gravitational lensing mass measurements from the Cluster Lensing And Supernova survey with Hubble (CLASH). We have compared the lensing masses to the Planck Sunyaev-Zeldovich (SZ) mass proxy for 21 clusters in common, employing a Bayesian analysis to simultaneously fit an idealized CLASH selection function and the distribution between the measured observables and true cluster mass. We used a tiered analysis strategy to explicitly demonstrate the importance of priors on weak lensing mass accuracy. In the case of an assumed constant bias, bSZ, between true cluster mass, M500, and the Planck mass proxy, MPL, our analysis constrains 1-bSZ = 0.73 ± 0.10 when moderate priors on weak lensing accuracy are used, including a zero-mean Gaussian with standard deviation of 8% to account for possible bias in lensing mass estimations. Our analysis explicitly accounts for possible selection bias effects in this calibration sourced by the CLASH selection function. Our constraint on the cluster mass scale is consistent with recent results from the Weighing the Giants program and the Canadian Cluster Comparison Project. It is also consistent, at 1.34σ, with the value needed to reconcile the Planck SZ cluster counts with Planck's base ΛCDM model fit to the primary cosmic microwave background anisotropies.

Does correcting astigmatism with toric lenses improve driving performance?

PubMed

Cox, Daniel J; Banton, Thomas; Record, Steven; Grabman, Jesse H; Hawkins, Ronald J

2015-04-01

Driving is a vision-based activity of daily living that impacts safety. Because visual disruption can compromise driving safety, contact lens wearers with astigmatism may pose a driving safety risk if they experience residual blur from spherical lenses that do not correct their astigmatism or if they experience blur from toric lenses that rotate excessively. Given that toric lens stabilization systems are continually improving, this preliminary study tested the hypothesis that astigmats wearing toric contact lenses, compared with spherical lenses, would exhibit better overall driving performance and driving-specific visual abilities. A within-subject, single-blind, crossover, randomized design was used to evaluate driving performance in 11 young adults with astigmatism (-0.75 to -1.75 diopters cylinder). Each participant drove a highly immersive, virtual reality driving simulator (210 degrees field of view) with (1) no correction, (2) spherical contact lens correction (ACUVUE MOIST), and (3) toric contact lens correction (ACUVUE MOIST for Astigmatism). Tactical driving skills such as steering, speed management, and braking, as well as operational driving abilities such as visual acuity, contrast sensitivity, and foot and arm reaction time, were quantified. There was a main effect for type of correction on driving performance (p = 0.05). Correction with toric lenses resulted in significantly safer tactical driving performance than no correction (p < 0.05), whereas correction with spherical lenses did not differ in driving safety from no correction (p = 0.118). Operational tests differentiated corrected from uncorrected performance for both spherical (p = 0.008) and toric (p = 0.011) lenses, but they were not sensitive enough to differentiate toric from spherical lens conditions. Given previous research showing that deficits in these tactical skills are predictive of future real-world collisions, these preliminary data suggest that correcting low to moderate astigmatism with toric lenses may be important to driving safety. Their merits relative to spherical lens correction require further investigation.

Effects of Soft Contact Lenses on Contrast Sensitivity

DTIC Science & Technology

1983-04-01

Problem ............... .......... 7 Subjects .. ............... ............... 9 *Material and Methods .. ............... ......... 14 Treatment of...abil- ity to achieve visual acuity comparable to that with their spectacle lenses, these patients frequently complain that their new vision is "not...available through Cadwell Laboratories) and the Arden Photographic Plates (available from American Optical Co.). In light of these new capabilities and

THE DOMINANCE OF METAL-RICH STREAMS IN STELLAR HALOS: A COMPARISON BETWEEN SUBSTRUCTURE IN M31 AND {lambda}CDM MODELS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilbert, Karoline M.; Font, Andreea S.; Johnston, Kathryn V.

2009-08-10

Extensive photometric and spectroscopic surveys of the Andromeda galaxy (M31) have discovered tidal debris features throughout M31's stellar halo. We present stellar kinematics and metallicities in fields with identified substructure from our on-going SPLASH survey of M31 red giant branch stars with the DEIMOS spectrograph on the Keck II 10 m telescope. Radial velocity criteria are used to isolate members of the kinematically cold substructures. The substructures are shown to be metal-rich relative to the rest of the dynamically hot stellar population in the fields in which they are found. We calculate the mean metallicity and average surface brightness ofmore » the various kinematical components in each field, and show that, on average, higher surface brightness features tend to be more metal-rich than lower surface brightness features. Simulations of stellar halo formation via accretion in a cosmological context are used to illustrate that the observed trend can be explained as a natural consequence of the observed dwarf galaxy mass-metallicity relation. A significant spread in metallicity at a given surface brightness is seen in the data; we show that this is due to time effects, namely, the variation in the time since accretion of the tidal streams' progenitor onto the host halo. We show that in this theoretical framework a relationship between the alpha-enhancement and surface brightness of tidal streams is expected, which arises from the varying times of accretion of the progenitor satellites onto the host halo. Thus, measurements of the alpha-enrichment, metallicity, and surface brightness of tidal debris can be used to reconstruct the luminosity and time of accretion onto the host halo of the progenitors of tidal streams.« less

Fine structure of the Arabidopsis stem cuticle: effects of fixation and changes over development.

PubMed

Shumborski, Sarah J; Samuels, A Lacey; Bird, David A

2016-10-01

The Arabidopsis cuticle, as observed by electron microscopy, consists primarily of the cutin/cutan matrix. The cuticle possesses a complex substructure, which is correlated with the presence of intracuticular waxes. The plant cuticle is composed of an insoluble polyester, cutin, and organic solvent soluble cuticular waxes, which are embedded within and coat the surface of the cutin matrix. How these components are arranged in the cuticle is not well understood. The Arabidopsis cuticle is commonly understood as 'amorphous,' lacking in ultrastructural features, and is often observed as a thin (~80-100 nm) electron-dense layer on the surface of the cell wall. To examine this cuticle in more detail, we examined cuticles from both rapidly elongating and mature sections of the stem and compared the preservation of the cuticles using conventional chemical fixation methods and high-pressure freezing/freeze-substitution (HPF/FS). We found that HPF/FS preparation revealed a complex cuticle substructure, which was more evident in older stems. We also found that the cuticle increases in thickness with development, indicating an accretion of polymeric material, likely in the form of the non-hydrolyzable polymer, cutan. When wax was extracted by chloroform immersion prior to sample preparation, the contribution of waxes to cuticle morphology was revealed. Overall, the electron-dense cuticle layer was still visible but there was loss of the cuticle substructure. Furthermore, the cuticle of cer6, a wax-deficient mutant, also lacked this substructure, suggesting that these fine striations were dependent on the presence of cuticular waxes. Our findings show that HPF/FS preparation can better preserve plant cuticles, but also provide new insights into the fine structure of the Arabidopsis cuticle.

Active optical zoom system

DOEpatents

Wick, David V.

2005-12-20

An active optical zoom system changes the magnification (or effective focal length) of an optical imaging system by utilizing two or more active optics in a conventional optical system. The system can create relatively large changes in system magnification with very small changes in the focal lengths of individual active elements by leveraging the optical power of the conventional optical elements (e.g., passive lenses and mirrors) surrounding the active optics. The active optics serve primarily as variable focal-length lenses or mirrors, although adding other aberrations enables increased utility. The active optics can either be LC SLMs, used in a transmissive optical zoom system, or DMs, used in a reflective optical zoom system. By appropriately designing the optical system, the variable focal-length lenses or mirrors can provide the flexibility necessary to change the overall system focal length (i.e., effective focal length), and therefore magnification, that is normally accomplished with mechanical motion in conventional zoom lenses. The active optics can provide additional flexibility by allowing magnification to occur anywhere within the FOV of the system, not just on-axis as in a conventional system.