46 CFR 52.01-120 - Safety valves and safety relief valves (modifies PG-67 through PG-73).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Safety valves and safety relief valves (modifies PG-67 through PG-73). 52.01-120 Section 52.01-120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-120 Safety valves and safety relief valves (modifies PG-67 through PG-73). (a)...

46 CFR 52.01-120 - Safety valves and safety relief valves (modifies PG-67 through PG-73).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Safety valves and safety relief valves (modifies PG-67 through PG-73). 52.01-120 Section 52.01-120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-120 Safety valves and safety relief valves (modifies PG-67 through PG-73). (a)...

46 CFR 52.01-120 - Safety valves and safety relief valves (modifies PG-67 through PG-73).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Safety valves and safety relief valves (modifies PG-67 through PG-73). 52.01-120 Section 52.01-120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-120 Safety valves and safety relief valves (modifies PG-67 through PG-73). (a)...

46 CFR 52.01-120 - Safety valves and safety relief valves (modifies PG-67 through PG-73).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Safety valves and safety relief valves (modifies PG-67 through PG-73). 52.01-120 Section 52.01-120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-120 Safety valves and safety relief valves (modifies PG-67 through PG-73). (a)...

49 CFR 229.109 - Safety valves.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Safety valves. 229.109 Section 229.109..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Steam Generators § 229.109 Safety valves. Every steam generator shall be equipped with at least two safety valves that have a...

49 CFR 229.109 - Safety valves.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Safety valves. 229.109 Section 229.109..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Steam Generators § 229.109 Safety valves. Every steam generator shall be equipped with at least two safety valves that have a...

30 CFR 250.601 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... installed: (a) Cutting paraffin; (b) Removing and setting pump-through-type tubing plugs, gas-lift valves...) Corrosion inhibitor treatment; (i) Removing or replacing subsurface pumps; (j) Through-tubing logging (diagnostics); (k) Wireline fishing; and (l) Setting and retrieving other subsurface flow-control devices...

30 CFR 250.601 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... installed: (a) Cutting paraffin; (b) Removing and setting pump-through-type tubing plugs, gas-lift valves...) Corrosion inhibitor treatment; (i) Removing or replacing subsurface pumps; (j) Through-tubing logging (diagnostics); (k) Wireline fishing; and (l) Setting and retrieving other subsurface flow-control devices...

30 CFR 250.601 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... installed: (a) Cutting paraffin; (b) Removing and setting pump-through-type tubing plugs, gas-lift valves...) Corrosion inhibitor treatment; (i) Removing or replacing subsurface pumps; (j) Through-tubing logging (diagnostics); (k) Wireline fishing; and (l) Setting and retrieving other subsurface flow-control devices...

Apparatus for passive removal of subsurface contaminants and mass flow measurement

DOEpatents

Jackson, Dennis G [Augusta, GA; Rossabi, Joseph [Aiken, SC; Riha, Brian D [Augusta, GA

2003-07-15

A system for improving the Baroball valve and a method for retrofitting an existing Baroball valve. This invention improves upon the Baroball valve by reshaping the interior chamber of the valve to form a flow meter measuring chamber. The Baroball valve sealing mechanism acts as a rotameter bob for determining mass flow rate through the Baroball valve. A method for retrofitting a Baroball valve includes providing static pressure ports and connecting a measuring device, to these ports, for measuring the pressure differential between the Baroball chamber and the well. A standard curve of nominal device measurements allows the mass flow rate to be determined through the retrofitted Baroball valve.

Apparatus for passive removal of subsurface contaminants and volume flow measurement

DOEpatents

Jackson, Dennis G.; Rossabi, Joseph; Riha, Brian D.

2002-01-01

A system for improving the Baroball valve and a method for retrofitting an existing Baroball valve. This invention improves upon the Baroball valve by reshaping the interior chamber of the valve to form a flow meter measuring chamber. The Baroball valve sealing mechanism acts as a rotameter bob for determining volume flow rate through the Baroball valve. A method for retrofitting a Baroball valve includes providing static pressure ports and connecting a measuring device, to these ports, for measuring the pressure differential between the Baroball chamber and the well. A standard curve of nominal device measurements allows the volume flow rate to be determined through the retrofitted Baroball valve.

46 CFR 176.704 - Breaking of safety valve seals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Breaking of safety valve seals. 176.704 Section 176.704... TONS) INSPECTION AND CERTIFICATION Repairs and Alterations § 176.704 Breaking of safety valve seals... the seal on a boiler safety valve on a vessel is broken. ...

46 CFR 176.704 - Breaking of safety valve seals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Breaking of safety valve seals. 176.704 Section 176.704... TONS) INSPECTION AND CERTIFICATION Repairs and Alterations § 176.704 Breaking of safety valve seals... the seal on a boiler safety valve on a vessel is broken. ...

Safety valve

DOEpatents

Bergman, Ulf C.

1984-01-01

The safety valve contains a resilient gland to be held between a valve seat and a valve member and is secured to the valve member by a sleeve surrounding the end of the valve member adjacent to the valve seat. The sleeve is movable relative to the valve member through a limited axial distance and a gap exists between said valve member and said sleeve.

46 CFR 115.704 - Breaking of safety valve seals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Breaking of safety valve seals. 115.704 Section 115.704... CERTIFICATION Repairs and Alterations § 115.704 Breaking of safety valve seals. The owner, managing operator, or master shall notify the cognizant OCMI as soon as practicable after the seal on a boiler safety valve on...

46 CFR 115.704 - Breaking of safety valve seals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Breaking of safety valve seals. 115.704 Section 115.704... CERTIFICATION Repairs and Alterations § 115.704 Breaking of safety valve seals. The owner, managing operator, or master shall notify the cognizant OCMI as soon as practicable after the seal on a boiler safety valve on...

46 CFR 196.30-20 - Breaking of safety valve seal.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Breaking of safety valve seal. 196.30-20 Section 196.30... OPERATIONS Reports of Accidents, Repairs, and Unsafe Equipment § 196.30-20 Breaking of safety valve seal. (a) If at any time it is necessary to break the seal on a safety valve for any purpose, the Chief...

46 CFR 196.30-20 - Breaking of safety valve seal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Breaking of safety valve seal. 196.30-20 Section 196.30... OPERATIONS Reports of Accidents, Repairs, and Unsafe Equipment § 196.30-20 Breaking of safety valve seal. (a) If at any time it is necessary to break the seal on a safety valve for any purpose, the Chief...

46 CFR 53.05-1 - Safety valve requirements for steam boilers (modifies HG-400 and HG-401).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Safety valve requirements for steam boilers (modifies HG... requirements for steam boilers (modifies HG-400 and HG-401). (a) The pressure relief valve requirements and the safety valve requirements for steam boilers must be as indicated in HG-400 and HG-401 of section IV of...

46 CFR 38.25-10 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Safety relief valves-TB/ALL. 38.25-10 Section 38.25-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS LIQUEFIED FLAMMABLE GASES Periodic Tests and Inspections § 38.25-10 Safety relief valves—TB/ALL. (a) The cargo tank safety relief valves shall...

46 CFR 38.25-10 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Safety relief valves-TB/ALL. 38.25-10 Section 38.25-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS LIQUEFIED FLAMMABLE GASES Periodic Tests and Inspections § 38.25-10 Safety relief valves—TB/ALL. (a) The cargo tank safety relief valves shall...

46 CFR 38.25-10 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Safety relief valves-TB/ALL. 38.25-10 Section 38.25-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS LIQUEFIED FLAMMABLE GASES Periodic Tests and Inspections § 38.25-10 Safety relief valves—TB/ALL. (a) The cargo tank safety relief valves shall...

46 CFR 38.25-10 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Safety relief valves-TB/ALL. 38.25-10 Section 38.25-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS LIQUEFIED FLAMMABLE GASES Periodic Tests and Inspections § 38.25-10 Safety relief valves—TB/ALL. (a) The cargo tank safety relief valves shall...

46 CFR 38.25-10 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Safety relief valves-TB/ALL. 38.25-10 Section 38.25-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS LIQUEFIED FLAMMABLE GASES Periodic Tests and Inspections § 38.25-10 Safety relief valves—TB/ALL. (a) The cargo tank safety relief valves shall...

46 CFR 38.10-15 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Safety relief valves-TB/ALL. 38.10-15 Section 38.10-15..., Fittings, and Accessory Equipment § 38.10-15 Safety relief valves—TB/ALL. (a) Each tank shall be fitted with or (subject to approval by the Commandant) connected to one or more safety relief valves designed...

46 CFR 162.018-8 - Procedure for approval.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Center, for re-approval. (c) Pre-approval tests. (1) Prior to approval of safety relief valves by the...) Reports of conducted tests on designs of safety relief valves different from those previously approved... approval of a new design or type of safety relief valve shall submit in quadruplicate detail drawings...

46 CFR 162.018-8 - Procedure for approval.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Center, for re-approval. (c) Pre-approval tests. (1) Prior to approval of safety relief valves by the...) Reports of conducted tests on designs of safety relief valves different from those previously approved... approval of a new design or type of safety relief valve shall submit in quadruplicate detail drawings...

46 CFR 162.018-8 - Procedure for approval.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Center, for re-approval. (c) Pre-approval tests. (1) Prior to approval of safety relief valves by the...) Reports of conducted tests on designs of safety relief valves different from those previously approved... approval of a new design or type of safety relief valve shall submit in quadruplicate detail drawings...

46 CFR 162.018-8 - Procedure for approval.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Center, for re-approval. (c) Pre-approval tests. (1) Prior to approval of safety relief valves by the...) Reports of conducted tests on designs of safety relief valves different from those previously approved... approval of a new design or type of safety relief valve shall submit in quadruplicate detail drawings...

46 CFR 162.018-8 - Procedure for approval.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Center, for re-approval. (c) Pre-approval tests. (1) Prior to approval of safety relief valves by the...) Reports of conducted tests on designs of safety relief valves different from those previously approved... approval of a new design or type of safety relief valve shall submit in quadruplicate detail drawings...

46 CFR 162.018-5 - Blow-down adjustment and popping tolerance.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-5 Blow-down adjustment and popping tolerance. (a) Safety relief valves shall be so.... Safety relief valves shall be designed to open sharply and reach full lift and capacity at the maximum...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND... and safety relief devices. (a) Each cylinder shall have a manually operated screw-down shutoff valve...

46 CFR 162.018-5 - Blow-down adjustment and popping tolerance.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-5 Blow-down adjustment and popping tolerance. (a) Safety relief valves shall be so.... Safety relief valves shall be designed to open sharply and reach full lift and capacity at the maximum...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND... and safety relief devices. (a) Each cylinder shall have a manually operated screw-down shutoff valve...

46 CFR 162.018-5 - Blow-down adjustment and popping tolerance.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-5 Blow-down adjustment and popping tolerance. (a) Safety relief valves shall be so.... Safety relief valves shall be designed to open sharply and reach full lift and capacity at the maximum...

46 CFR 162.018-5 - Blow-down adjustment and popping tolerance.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-5 Blow-down adjustment and popping tolerance. (a) Safety relief valves shall be so.... Safety relief valves shall be designed to open sharply and reach full lift and capacity at the maximum...

46 CFR 162.018-5 - Blow-down adjustment and popping tolerance.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-5 Blow-down adjustment and popping tolerance. (a) Safety relief valves shall be so.... Safety relief valves shall be designed to open sharply and reach full lift and capacity at the maximum...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND... and safety relief devices. (a) Each cylinder shall have a manually operated screw-down shutoff valve...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND... and safety relief devices. (a) Each cylinder shall have a manually operated screw-down shutoff valve...

30 CFR 250.445 - What are the requirements for kelly valves, inside BOPs, and drill-string safety valves?

Code of Federal Regulations, 2014 CFR

2014-07-01

..., inside BOPs, and drill-string safety valves? 250.445 Section 250.445 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System...

30 CFR 250.445 - What are the requirements for kelly valves, inside BOPs, and drill-string safety valves?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., inside BOPs, and drill-string safety valves? 250.445 Section 250.445 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System...

30 CFR 250.445 - What are the requirements for kelly valves, inside BOPs, and drill-string safety valves?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., inside BOPs, and drill-string safety valves? 250.445 Section 250.445 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System...

46 CFR 52.20-17 - Opening between boiler and safety valve (modifies PFT-44).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Opening between boiler and safety valve (modifies PFT-44). 52.20-17 Section 52.20-17 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS Requirements for Firetube Boilers § 52.20-17 Opening between boiler and safety valve...

46 CFR 52.20-17 - Opening between boiler and safety valve (modifies PFT-44).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Opening between boiler and safety valve (modifies PFT-44). 52.20-17 Section 52.20-17 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS Requirements for Firetube Boilers § 52.20-17 Opening between boiler and safety valve...

46 CFR 52.20-17 - Opening between boiler and safety valve (modifies PFT-44).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Opening between boiler and safety valve (modifies PFT-44). 52.20-17 Section 52.20-17 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS Requirements for Firetube Boilers § 52.20-17 Opening between boiler and safety valve...

46 CFR 52.20-17 - Opening between boiler and safety valve (modifies PFT-44).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Opening between boiler and safety valve (modifies PFT-44). 52.20-17 Section 52.20-17 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS Requirements for Firetube Boilers § 52.20-17 Opening between boiler and safety valve...

46 CFR 52.20-17 - Opening between boiler and safety valve (modifies PFT-44).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Opening between boiler and safety valve (modifies PFT-44). 52.20-17 Section 52.20-17 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS Requirements for Firetube Boilers § 52.20-17 Opening between boiler and safety valve...

30 CFR 250.801 - Subsurface safety devices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... conditions, hydrate formation, or paraffins, an alternate setting depth of the subsurface safety device may... conditions such as permafrost, unstable bottom conditions, hydrate formations, and paraffins. (g) Subsurface...

77 FR 28669 - Pipeline Safety: Information Collection Activities, Excess Flow Valve Census

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-15

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2012-0086] Pipeline Safety: Information Collection Activities, Excess Flow Valve Census AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and request for...

Clinical Evaluation of a Safety-device to Prevent Urinary Catheter Inflation Related Injuries.

PubMed

Davis, Niall F; Cunnane, Eoghan M; Mooney, Rory O'C; Forde, James C; Walsh, Michael T

2018-05-01

To evaluate the feasibility of a novel "safety-valve" device for preventing catheter related urethral trauma during urethral catheterization (UC). To assess the opinions of clinicians on the performance of the safety-valve device. A validated prototype "safety-valve" device for preventing catheter balloon inflation related urethral injuries was prospectively piloted in male patients requiring UC in a tertiary referral teaching hospital (n = 100). The device allows fluid in the catheter system to decant through an activated safety threshold pressure valve if the catheter anchoring balloon is misplaced. Users evaluated the "safety-valve" with an anonymous questionnaire. The primary outcome measurement was prevention of anchoring balloon inflation in the urethra. Secondary outcome measurement was successful inflation of urinary catheter anchoring balloon in the bladder. Patient age was 76 ± 12 years and American Society of Anaesthesiologists grade was 3 ± 1.4. The "safety-valve" was utilized by 34 clinicians and activated in 7% (n = 7/100) patients during attempted UC, indicating that the catheter anchoring balloon was incorrectly positioned in the patient's urethra. In these 7 cases, the catheter was successfully manipulated into the urinary bladder and inflated. 31 of 34 (91%) clinicians completed the questionnaire. Ten percent (n = 3/31) of respondents had previously inflated a urinary catheter anchoring balloon in the urethra and 100% (n = 31) felt that a safety mechanism for preventing balloon inflation in the urethra should be compulsory for all UCs. The safety-valve device piloted in this clinical study offers an effective solution for preventing catheter balloon inflation related urethral injuries. Copyright © 2018 Elsevier Inc. All rights reserved.

46 CFR 53.05-1 - Safety valve requirements for steam boilers (modifies HG-400 and HG-401).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Safety valve requirements for steam boilers (modifies HG-400 and HG-401). 53.05-1 Section 53.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS Pressure Relieving Devices (Article 4) § 53.05-1 Safety valve requirements for steam boilers (modifies HG...

46 CFR 53.05-1 - Safety valve requirements for steam boilers (modifies HG-400 and HG-401).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Safety valve requirements for steam boilers (modifies HG-400 and HG-401). 53.05-1 Section 53.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS Pressure Relieving Devices (Article 4) § 53.05-1 Safety valve requirements for steam boilers (modifies HG...

46 CFR 53.05-1 - Safety valve requirements for steam boilers (modifies HG-400 and HG-401).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Safety valve requirements for steam boilers (modifies HG-400 and HG-401). 53.05-1 Section 53.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS Pressure Relieving Devices (Article 4) § 53.05-1 Safety valve requirements for steam boilers (modifies HG...

46 CFR 53.05-1 - Safety valve requirements for steam boilers (modifies HG-400 and HG-401).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Safety valve requirements for steam boilers (modifies HG-400 and HG-401). 53.05-1 Section 53.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS Pressure Relieving Devices (Article 4) § 53.05-1 Safety valve requirements for steam boilers (modifies HG...

46 CFR 98.25-40 - Valves, fittings, and accessories.

Code of Federal Regulations, 2013 CFR

2013-10-01

... located at the highest practical point. The thermometer well shall terminate in the liquid space and be... and discharge liquid and vapor shut-off valves, safety relief valves, liquid level gaging devices... to the tanks, except safety devices and liquid level gaging devices, shall have manually operated...

46 CFR 98.25-40 - Valves, fittings, and accessories.

Code of Federal Regulations, 2012 CFR

2012-10-01

... located at the highest practical point. The thermometer well shall terminate in the liquid space and be... and discharge liquid and vapor shut-off valves, safety relief valves, liquid level gaging devices... to the tanks, except safety devices and liquid level gaging devices, shall have manually operated...

46 CFR 98.25-40 - Valves, fittings, and accessories.

Code of Federal Regulations, 2011 CFR

2011-10-01

... located at the highest practical point. The thermometer well shall terminate in the liquid space and be... and discharge liquid and vapor shut-off valves, safety relief valves, liquid level gaging devices... to the tanks, except safety devices and liquid level gaging devices, shall have manually operated...

46 CFR 98.25-40 - Valves, fittings, and accessories.

Code of Federal Regulations, 2014 CFR

2014-10-01

... located at the highest practical point. The thermometer well shall terminate in the liquid space and be... and discharge liquid and vapor shut-off valves, safety relief valves, liquid level gaging devices... to the tanks, except safety devices and liquid level gaging devices, shall have manually operated...

Study on high reliability safety valve for railway vehicle

NASA Astrophysics Data System (ADS)

Zhang, Xuan; Chen, Ruikun; Zhang, Shixi; Xu, BuDu

2017-09-01

Now, the realization of most of the functions of the railway vehicles rely on compressed air, so the demand for compressed air is growing higher and higher. This safety valve is a protection device for pressure limitation and pressure relief in an air supply system of railway vehicles. I am going to introduce the structure, operating principle, research and development process of the safety valve designed by our company in this document.

46 CFR 56.50-25 - Safety and relief valve escape piping.

Code of Federal Regulations, 2010 CFR

2010-10-01

... supported and installed so that no stress is transmitted to the safety valve body. (c) Safety or relief... or to a remote position to minimize the hazardous effect of the escaping steam. (d) The effect of the...

49 CFR 179.220-24 - Tests of pressure relief valves.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.220-24 Tests of pressure relief valves. Each safety relief valve must be tested by air or gas for compliance with § 179.15...

49 CFR 179.220-24 - Tests of pressure relief valves.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.220-24 Tests of pressure relief valves. Each safety relief valve must be tested by air or gas for compliance with § 179.15...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Liquefied Petroleum Gases for Cooking and Heating § 58.16-15 Valves...

30 CFR 250.445 - What are the requirements for kelly valves, inside BOPs, and drill-string safety valves?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., inside BOPs, and drill-string safety valves? 250.445 Section 250.445 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.445 What...

30 CFR 250.445 - What are the requirements for kelly valves, inside BOPs, and drill-string safety valves?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., inside BOPs, and drill-string safety valves? 250.445 Section 250.445 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop...

46 CFR 162.018-2 - Scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-2 Scope. (a) This specification covers requirements for the design, construction and testing of safety relief valves intended for...

46 CFR 162.018-2 - Scope.

Code of Federal Regulations, 2014 CFR

2014-10-01

... APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-2 Scope. (a) This specification covers requirements for the design, construction and testing of safety relief valves intended for...

46 CFR 162.018-2 - Scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

... APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-2 Scope. (a) This specification covers requirements for the design, construction and testing of safety relief valves intended for...

46 CFR 162.018-2 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-2 Scope. (a) This specification covers requirements for the design, construction and testing of safety relief valves intended for...

46 CFR 162.018-2 - Scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

... APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-2 Scope. (a) This specification covers requirements for the design, construction and testing of safety relief valves intended for...

30 CFR 57.4603 - Closure of valves.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Closure of valves. 57.4603 Section 57.4603 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and...

30 CFR 56.4603 - Closure of valves.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Closure of valves. 56.4603 Section 56.4603 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and...

46 CFR 162.018-6 - Marking.

Code of Federal Regulations, 2013 CFR

2013-10-01

...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-6 Marking. (a) Each safety relief valve shall be plainly marked by the manufacturer with the required data...-* *”. * * Number to be assigned by the Commanding Officer, USCG Marine Safety Center. (b) [Reserved] [CGFR 68-82...

46 CFR 162.018-6 - Marking.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-6 Marking. (a) Each safety relief valve shall be plainly marked by the manufacturer with the required data...-* *”. * * Number to be assigned by the Commanding Officer, USCG Marine Safety Center. (b) [Reserved] [CGFR 68-82...

46 CFR 162.018-6 - Marking.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-6 Marking. (a) Each safety relief valve shall be plainly marked by the manufacturer with the required data...-* *”. * * Number to be assigned by the Commanding Officer, USCG Marine Safety Center. (b) [Reserved] [CGFR 68-82...

49 CFR 179.100-19 - Tests of safety relief valves.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Tests of safety relief valves. 179.100-19 Section... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120...

49 CFR 179.100-19 - Tests of safety relief valves.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Tests of safety relief valves. 179.100-19 Section... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-19...

49 CFR 179.100-19 - Tests of safety relief valves.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Tests of safety relief valves. 179.100-19 Section... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-19...

49 CFR 179.100-19 - Tests of safety relief valves.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Tests of safety relief valves. 179.100-19 Section... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-19...

Characterization of Subsurface Defects in Ceramic Rods by Laser Scattering and Fractography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, J. M.; Sun, J. G.; Andrews, M. J.

2006-03-06

Silicon nitride ceramics are leading materials being evaluated for valve train components in diesel engine applications. The surface and subsurface defects and damage induced by surface machining can significantly affect component strength and lifetime. In this study, a nondestructive evaluation (NDE) technique based upon laser scattering has been utilized to analyze eight transversely ground silicon nitride cylindrical rods before fracture tests. The fracture origins (machining cracks or material-inherent flaws) identified by fractography after fracture testing were correlated with laser scattering images. The results indicate that laser scattering is able to identify possible fracture origin in the silicon nitride subsurface withoutmore » the need for destructive fracture tests.« less

Water hammer caused by closure of turbine safety spherical valves

NASA Astrophysics Data System (ADS)

Karadžić, U.; Bergant, A.; Vukoslavčević, P.

2010-08-01

This paper investigates water hammer effects caused by closure of spherical valves against the discharge. During the first phase of modernisation of Perućica high-head hydropower plant (HPP), Montenegro, safety spherical valves (inlet turbine valves) have been refurbished on the first two Pelton turbine units. The valve closure is controlled by the valve actuator (hydraulic servomotor). Because the torque acting on the valve body is dependent on flow conditions the valve closing time may vary significantly for different flow velocities (passive valve). For the passive valve the torques acting on the valve body should be considered in the valve model. The valve closing time results from numerical simulation. On the contrary, for the active valve the valve closing time is assumed prior to simulation. The spherical valve boundary condition is incorporated into the method of characteristics (MOC) algorithm. The staggered (diamond) grid in applying the MOC is used in this paper. The passive valve boundary condition is described by the water hammer equations, the valve equation that relates discharge to pressure head drop and the dynamic equation of the valve body motion (torque equation). The active valve boundary condition is described by the first two equations, respectively. Standard quasi-steady friction model is used for estimating friction losses in plant's tunnel and penstocks. Numerical results using both the active and the passive spherical valve models are compared with results of measurements. It has been found that the influence of flow conditions on the spherical valve closing time is minor for the cases considered. Computed and measured results agree reasonably well.

Direct transcatheter aortic valve implantation with self-expandable bioprosthesis: feasibility and safety.

PubMed

Fiorina, Claudia; Maffeo, Diego; Curello, Salvatore; Lipartiti, Felicia; Chizzola, Giuliano; D'Aloia, Antonio; Adamo, Marianna; Mastropierro, Rosy; Gavazzi, Emanuele; Ciccarese, Camilla; Chiari, Ermanna; Ettori, Federica

2014-06-01

Balloon valvuloplasty has been considered a mandatory step of the transcatheter aortic valve implantation (TAVI), although it is not without risk. The aim of this work was to evaluate the feasibility and safety of TAVI performed without pre-dilation (direct TAVI) of the stenosed aortic valve. Between June 2012 and June 2013, 55 consecutive TAVI performed without pre-dilation at our institution using the self-expandable CoreValve prosthesis (Medtronic, Minneapolis, MN) were analyzed and compared with 45 pre-dilated TAVI performed the previous year. Inclusion criteria were a symptomatic and severe aortic stenosis. Exclusion criteria were defined as presence of pure aortic regurgitation, degenerated surgical bioprosthesis or bicuspid aortic valve and prior procedure of balloon aortic valvuloplasty performed as a bridge to TAVI. High-burden calcification in the device landing zone, assessed by CT scan, was found in most of the patients. The valve size implanted was similar in both groups. Device success was higher in direct TAVI (85%vs.64%,p=0.014), mostly driven by a significant lower incidence of paravalvular leak (PVL≥2;9%vs.33%,p=0.02). Safety combined end point at 30 days was similar in both groups. Compared to TAVI with pre-dilation, direct TAVI is feasible regardless of the presence of bulky calcified aortic valve and the valve size implanted. Device success was higher in direct TAVI, mostly driven by a lower incidence of paravalvular leak. Safety at 30 days was similar in two groups. Copyright © 2014 Elsevier Inc. All rights reserved.

77 FR 5472 - Pipeline Safety: Expanding the Use of Excess Flow Valves in Gas Distribution Systems to...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-03

..., Regulatory Certainty, and Job Creation Act of 2011 (PL112-90), have imposed additional demands on their... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part 192 [Docket ID PHMSA-2011-0009] RIN 2137-AE71 Pipeline Safety: Expanding the Use of Excess Flow Valves...

Fluid-faulting interactions: Fracture-mesh and fault-valve behavior in the February 2014 Mammoth Mountain, California, earthquake swarm

USGS Publications Warehouse

Shelly, David R.; Taira, Taka’aki; Prejean, Stephanie; Hill, David P.; Dreger, Douglas S.

2015-01-01

Faulting and fluid transport in the subsurface are highly coupled processes, which may manifest seismically as earthquake swarms. A swarm in February 2014 beneath densely monitored Mammoth Mountain, California, provides an opportunity to witness these interactions in high resolution. Toward this goal, we employ massive waveform-correlation-based event detection and relative relocation, which quadruples the swarm catalog to more than 6000 earthquakes and produces high-precision locations even for very small events. The swarm's main seismic zone forms a distributed fracture mesh, with individual faults activated in short earthquake bursts. The largest event of the sequence, M 3.1, apparently acted as a fault valve and was followed by a distinct wave of earthquakes propagating ~1 km westward from the updip edge of rupture, 1–2 h later. Late in the swarm, multiple small, shallower subsidiary faults activated with pronounced hypocenter migration, suggesting that a broader fluid pressure pulse propagated through the subsurface.

46 CFR 56.50-20 - Pressure relief piping.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PIPING SYSTEMS AND... authorized by the Marine Safety Center. (b) Discharge lines (reproduces 122.6.2(d)). Discharge lines from pressure-relieving safety devices shall be designed to facilitate drainage. (c) Stop valves. Stop valves...

46 CFR 56.50-20 - Pressure relief piping.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PIPING SYSTEMS AND... authorized by the Marine Safety Center. (b) Discharge lines (reproduces 122.6.2(d)). Discharge lines from pressure-relieving safety devices shall be designed to facilitate drainage. (c) Stop valves. Stop valves...

OPERATING PARAMETERS TO MINIMIZE EMISSIONS DURING ROTARY KILN EMERGENCY SAFETY VENT OPENINGS

EPA Science Inventory

Certain designs of hazardous waste incinerator systems include emergency safety vents (ESVs). ESVs (also called dump stacks, vent stacks, emergency by-pass stacks, thermal relief valves, and pressure relief valves) are regarded as true emergency devices. Their purpose is to vent ...

Line-scan Raman imaging and spectroscopy platform for surface and subsurface evaluation of food safety and quality

USDA-ARS?s Scientific Manuscript database

Both surface and subsurface food inspection is important since interesting safety and quality attributes can be at different sample locations. This paper presents a multipurpose line-scan Raman platform for food safety and quality research, which can be configured for Raman chemical imaging (RCI) mo...

Design and efficacy of a single-use bioreactor for heart valve tissue engineering.

PubMed

Converse, Gabriel L; Buse, Eric E; Neill, Kari R; McFall, Christopher R; Lewis, Holley N; VeDepo, Mitchell C; Quinn, Rachael W; Hopkins, Richard A

2017-02-01

Heart valve tissue engineering offers the promise of improved treatments for congenital heart disorders; however, widespread clinical availability of a tissue engineered heart valve (TEHV) has been hindered by scientific and regulatory concerns, including the lack of a disposable, bioreactor system for nondestructive valve seeding and mechanical conditioning. Here we report the design for manufacture and the production of full scale, functional prototypes of such a system. To evaluate the efficacy of this bioreactor as a tool for seeding, ovine aortic valves were decellularized and subjected to seeding with human mesenchymal stem cells (hMSC). The effects of pulsatile conditioning using cyclic waveforms tuned to various negative and positive chamber pressures were evaluated, with respect to the seeding of cells on the decellularized leaflet and the infiltration of seeded cells into the interstitium of the leaflet. Infiltration of hMSCs into the aortic valve leaflet was observed following 72 h of conditioning under negative chamber pressure. Additional conditioning under positive pressure improved cellular infiltration, while retaining gene expression within the MSC-valve interstitial cell phenotype lineage. This protocol resulted in a subsurface pilot population of cells, not full tissue recellularization. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 249-259, 2017. © 2015 Wiley Periodicals, Inc.

33 CFR 183.528 - Fuel stop valves.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Fuel stop valves. 183.528 Section...) BOATING SAFETY BOATS AND ASSOCIATED EQUIPMENT Fuel Systems Equipment Standards § 183.528 Fuel stop valves. (a) Each electrically operated fuel stop valve in a fuel line between the fuel tank and the engine...

46 CFR 98.25-60 - Safety relief valves.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Safety relief valves. 98.25-60 Section 98.25-60 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk...

46 CFR 98.25-60 - Safety relief valves.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Safety relief valves. 98.25-60 Section 98.25-60 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk...

46 CFR 98.25-60 - Safety relief valves.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Safety relief valves. 98.25-60 Section 98.25-60 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk...

46 CFR 98.25-60 - Safety relief valves.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Safety relief valves. 98.25-60 Section 98.25-60 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk...

46 CFR 98.25-60 - Safety relief valves.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Safety relief valves. 98.25-60 Section 98.25-60 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk...

75 FR 2894 - Withdrawal of Regulatory Guide 1.148

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-19

... Valve Assemblies in Systems Important to Safety in Nuclear Power Plants.'' FOR FURTHER INFORMATION... for Active Valve Assemblies in Systems Important to Safety in Nuclear Power Plants.'' RG 1.148 was... qualifying active mechanical equipment used in nuclear power plants. The NRC is withdrawing RG 1.148 because...

High cleanliness globe valve with sine mechanism drive

NASA Astrophysics Data System (ADS)

Luo, Hu

2018-06-01

This paper gives a new type of quick-opening globe valve for life support pneumatic control system of the safety cabin at underground coal mine. The valve adopts the sine mechanism to transmit the rotating of the handle in the range of 90° to the reciprocating motion of the spool. The mechanism implements the quick-opening function of the valve through controlling the contact and separation between the O-ring and the end face of the valve. Since there is no relative sliding between the sealing interfaces, the valve solute uncontrollable disadvantage wear particles which produced by package ball valve, to ensure high cleanliness in flow path. Traditional transmission mechanism has a reinforcement effect and reduce handle open torque. By the finite element method, the relationship between the contact force and the compression of O-ring is analyzed to provide the boundary condition for the calculation of the rotational torque. Meanwhile the velocity field and pressure field along the flow path are simulated. The caliber size of the valve and the flow resistance coefficient are obtained. There is higher cleanliness, more reliable sealing, smaller handle open torque advantage compared with existing packing ball valve. The above work presents a new technical approach for the design of pneumatic control valve of the safety cabin.

Design and development of a large diameter high pressure fast acting propulsion valve and valve actuator

NASA Technical Reports Server (NTRS)

Srinivasan, K. V.

1986-01-01

The design and development of a large diameter high pressure quick acting propulsion valve and valve actuator is described. The valve is the heart of a major test facility dedicated to conducting full scale performance tests of aircraft landing systems. The valve opens in less than 300 milliseconds releasing a 46-centimeter- (18-in.-) diameter water jet and closes in 300 milliseconds. The four main components of the valve, i.e., valve body, safety shutter, high speed shutter, and pneumatic-hydraulic actuator, are discussed. This valve is unique and may have other aerospace and industrial applications.

Design and Development of a Large Diameter, High Pressure, Fast Acting Propulsion Valve and Valve Actuator

NASA Technical Reports Server (NTRS)

Srinivasan, K. V.

1986-01-01

This paper describes the design and development of a large diameter high pressure quick acting propulsion valve and valve actuator. The valve is the heart of a major test facility dedicated to conducting full scale performance tests of aircraft landing gear systems. The valve opens in less than 300 milliseconds releasing a 46 cm (18 in) diameter water jet and closes in 300 milliseconds. The four main components of the valve, i.e., valve body, safety shutter, high speed shutter, and pneumatic-hydraulic actuator, are discussed. This valve is unique and may have other aerospace and industrial applications.

76 FR 72666 - Pipeline Safety: Expanding the Use of Excess Flow Valves in Gas Distribution Systems to...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-25

... technical feasibility and cost of the installation of such valves; (D) The public safety benefits of the... public comment regarding the technical challenges, and the potential costs and the potential benefits of... a cost-benefit perspective. DATES: Persons interested in submitting written comments on this ANPRM...

46 CFR 61.05-20 - Boiler safety valves.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Boiler safety valves. 61.05-20 Section 61.05-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PERIODIC TESTS AND..., superheater, or reheater of a boiler shall be tested at the interval specified by table 61.05-10. [CGD 95-028...

46 CFR 61.05-20 - Boiler safety valves.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Boiler safety valves. 61.05-20 Section 61.05-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PERIODIC TESTS AND..., superheater, or reheater of a boiler shall be tested at the interval specified by table 61.05-10. [CGD 95-028...

46 CFR 61.05-20 - Boiler safety valves.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Boiler safety valves. 61.05-20 Section 61.05-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PERIODIC TESTS AND..., superheater, or reheater of a boiler shall be tested at the interval specified by table 61.05-10. [CGD 95-028...

46 CFR 61.05-20 - Boiler safety valves.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Boiler safety valves. 61.05-20 Section 61.05-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PERIODIC TESTS AND..., superheater, or reheater of a boiler shall be tested at the interval specified by table 61.05-10. [CGD 95-028...

46 CFR 61.05-20 - Boiler safety valves.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Boiler safety valves. 61.05-20 Section 61.05-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PERIODIC TESTS AND..., superheater, or reheater of a boiler shall be tested at the interval specified by table 61.05-10. [CGD 95-028...

Anaesthesia Gas Supply: Gas Cylinders

PubMed Central

Srivastava, Uma

2013-01-01

Invention of oxygen cylinder was one of the most important developments in the field of medical practice. Oxygen and other gases were compressed and stored at high pressure in seamless containers constructed from hand-forged steel in1880. Materials technology has continued to evolve and now medical gas cylinders are generally made of steel alloys or aluminum. The filling pressure as well as capacity has increased considerably while at the same time the weight of cylinders has reduced. Today oxygen cylinder of equivalent size holds a third more oxygen but weighs about 20 kg less. The cylinders are of varying sizes and are color coded. They are tested at regular intervals by the manufacturer using hydraulic, impact, and tensile tests. The top end of the cylinder is fitted with a valve with a variety of number and markings stamped on it. Common valve types include: Pin index valve, bull nose, hand wheel and integral valve. The type of valve varies with cylinder size. Small cylinders have a pin index valve while large have a bull nose type. Safety features in the cylinder are: Color coding, pin index, pressure relief device, Bodok seal, and label attached etc., Safety rules and guidelines must be followed during storage, installation and use of cylinders to ensure safety of patients, hospital personnel and the environment. PMID:24249883

Anaesthesia gas supply: gas cylinders.

PubMed

Srivastava, Uma

2013-09-01

Invention of oxygen cylinder was one of the most important developments in the field of medical practice. Oxygen and other gases were compressed and stored at high pressure in seamless containers constructed from hand-forged steel in1880. Materials technology has continued to evolve and now medical gas cylinders are generally made of steel alloys or aluminum. The filling pressure as well as capacity has increased considerably while at the same time the weight of cylinders has reduced. Today oxygen cylinder of equivalent size holds a third more oxygen but weighs about 20 kg less. The cylinders are of varying sizes and are color coded. They are tested at regular intervals by the manufacturer using hydraulic, impact, and tensile tests. The top end of the cylinder is fitted with a valve with a variety of number and markings stamped on it. Common valve types include: Pin index valve, bull nose, hand wheel and integral valve. The type of valve varies with cylinder size. Small cylinders have a pin index valve while large have a bull nose type. Safety features in the cylinder are: Color coding, pin index, pressure relief device, Bodok seal, and label attached etc., Safety rules and guidelines must be followed during storage, installation and use of cylinders to ensure safety of patients, hospital personnel and the environment.

The JUPITER registry: One-year outcomes of transapical aortic valve implantation using a second generation transcatheter heart valve for aortic regurgitation.

PubMed

Silaschi, Miriam; Conradi, Lenard; Wendler, Olaf; Schlingloff, Friederike; Kappert, Utz; Rastan, Ardawan J; Baumbach, Hardy; Holzhey, David; Eichinger, Walter; Bader, Ralf; Treede, Hendrik

2018-06-01

We present 1-year outcomes of the post-market registry of a next-generation transcatheter heart valve used for aortic regurgitation (AR). Transcatheter aortic valve replacement (TAVR) is routine in high-risk patients with aortic stenosis but is not recommended for AR. The JenaValve™ (JenaValve Technology GmbH, Munich, Germany) overcomes technical challenges in AR patients through a leaflet clipping mechanism. The JenaValve EvalUation of Long Term Performance and Safety In PaTients with SEvere Aortic Stenosis oR Aortic Insufficiency (JUPITER) Registry is a European study to evaluate safety and effectiveness of this THV. From 2012-2015, 30 patients with AR were enrolled. Mean age was 74.4 ± 9.3 years. Procedural success was 96.7% (29/30). One patient was converted to open surgery. No annular rupture or coronary ostia obstruction occurred. Mortality at 30 days was 10.0% (3/30). Combined safety endpoint was met in 13.3% (4/30). Paravalvular regurgitation was not present/trivial in 84.6% (22/26) and mild in 15.4% (4/26). Rate of permanent pacemaker implantation was 3.8% (1/26). One-year Kaplan-Meier survival was 79.9%, one-year combined efficacy was 73.1% (19/30). No further strokes were observed during 1 year of follow-up. The JenaValve overcomes technical challenges of TAVR in AR through a clipping mechanism. We report satisfactory outcomes of a multicenter registry using the JenaValve for predominant AR, as rate of THV embolization, residual AR and permanent pacemaker implantation was low. One-year results using the JenaValve for AR encourage its use for this indication. © 2017 Wiley Periodicals, Inc.

Innovative safety valve selection techniques and data.

PubMed

Miller, Curt; Bredemyer, Lindsey

2007-04-11

The new valve data resources and modeling tools that are available today are instrumental in verifying that that safety levels are being met in both current installations and project designs. If the new ISA 84 functional safety practices are followed closely, good industry validated data used, and a user's maintenance integrity program strictly enforced, plants should feel confident that their design has been quantitatively reinforced. After 2 years of exhaustive reliability studies, there are now techniques and data available to support this safety system component deficiency. Everyone who has gone through the process of safety integrity level (SIL) verification (i.e. reliability math) will appreciate the progress made in this area. The benefits of these advancements are improved safety with lower lifecycle costs such as lower capital investment and/or longer testing intervals. This discussion will start with a review of the different valve, actuator, and solenoid/positioner combinations that can be used and their associated application restraints. Failure rate reliability studies (i.e. FMEDA) and data associated with the final combinations will then discussed. Finally, the impact of the selections on each safety system's SIL verification will be reviewed.

49 CFR 192.179 - Transmission line valves.

Code of Federal Regulations, 2010 CFR

2010-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.179 Transmission line valves. (a) Each transmission line, other than offshore segments, must have sectionalizing block... 49 Transportation 3 2010-10-01 2010-10-01 false Transmission line valves. 192.179 Section 192.179...

49 CFR 192.179 - Transmission line valves.

Code of Federal Regulations, 2013 CFR

2013-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.179 Transmission line valves. (a) Each transmission line, other than offshore segments, must have sectionalizing block... 49 Transportation 3 2013-10-01 2013-10-01 false Transmission line valves. 192.179 Section 192.179...

49 CFR 192.179 - Transmission line valves.

Code of Federal Regulations, 2011 CFR

2011-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.179 Transmission line valves. (a) Each transmission line, other than offshore segments, must have sectionalizing block... 49 Transportation 3 2011-10-01 2011-10-01 false Transmission line valves. 192.179 Section 192.179...

49 CFR 192.179 - Transmission line valves.

Code of Federal Regulations, 2014 CFR

2014-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.179 Transmission line valves. (a) Each transmission line, other than offshore segments, must have sectionalizing block... 49 Transportation 3 2014-10-01 2014-10-01 false Transmission line valves. 192.179 Section 192.179...

49 CFR 192.179 - Transmission line valves.

Code of Federal Regulations, 2012 CFR

2012-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.179 Transmission line valves. (a) Each transmission line, other than offshore segments, must have sectionalizing block... 49 Transportation 3 2012-10-01 2012-10-01 false Transmission line valves. 192.179 Section 192.179...

14 CFR 121.239 - Oil valves.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Oil valves. 121.239 Section 121.239..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.239 Oil valves. (a) Each oil... oil shutoff means must not prevent feathering the propeller, unless equivalent safety provisions are...

14 CFR 121.239 - Oil valves.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Oil valves. 121.239 Section 121.239..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.239 Oil valves. (a) Each oil... oil shutoff means must not prevent feathering the propeller, unless equivalent safety provisions are...

14 CFR 121.239 - Oil valves.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Oil valves. 121.239 Section 121.239..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.239 Oil valves. (a) Each oil... oil shutoff means must not prevent feathering the propeller, unless equivalent safety provisions are...

14 CFR 121.239 - Oil valves.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Oil valves. 121.239 Section 121.239..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.239 Oil valves. (a) Each oil... oil shutoff means must not prevent feathering the propeller, unless equivalent safety provisions are...

14 CFR 121.239 - Oil valves.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Oil valves. 121.239 Section 121.239..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.239 Oil valves. (a) Each oil... oil shutoff means must not prevent feathering the propeller, unless equivalent safety provisions are...

Development Specification for RV-346/348 Positive Pressure Relief Valves (PPRV)

NASA Technical Reports Server (NTRS)

Ralston, Russell L.

2017-01-01

This specification establishes the requirements for design, performance, safety, testing, and manufacture of the RV-346 and RV-348, Positive Pressure Relief Valve (PPRV) as part of the Advanced Extravehicular Mobility Unit (EMU)(AEMU) Portable Life Support System (PLSS). The RV-346 serves as the Positive Pressure Relief Valve (PPRV), and the RV-348 serves as the Secondary Positive Pressure Relief Valve (SPPRV).

Refuge alternatives relief valve testing and design with updated test stand.

PubMed

Lutz, T J; Bissert, P T; Homce, G T; Yonkey, J A

2018-03-01

Underground refuge alternatives require an air source to supply breathable air to the occupants. This requires pressure relief valves to prevent unsafe pressures from building up within the refuge alternative. The U.S. Mine Safety and Health Administration (MSHA) mandates that pressure relief valves prevent pressure from exceeding 1.25 kPa (0.18 psi), or as specified by the manufacturer, above mine atmospheric pressure when a fan or compressor is used for the air supply. The U.S. National Institute for Occupational Safety and Health (NIOSH) tested a variety of pressure relief valves using an instrumented test fixture consisting of data acquisition equipment, a centrifugal blower, ductwork and various sensors to determine if the subject pressure relief valves meet the MSHA requirement. Relief pressures and flow characteristics, including opening pressure and flow rate, were measured for five different pressure relief valves under a variety of conditions. The subject pressure relief valves included two off-the-shelf modified check valves, two check valves used in MSHA-approved built-in-place refuge alternatives, and a commercially available valve that was designed for a steel refuge alternative and is currently being used in some built-in-place refuge alternatives. The test results showed relief pressures ranging from 0.20 to 1.53 kPa (0.03 to 0.22 psi) and flow rates up to 19.3 m 3 /min (683 scfm). As tested, some of the pressure relief valves did not meet the 1.25 kPa (0.18 psi) relief specification.

CardiaMed mechanical valve: mid-term results of a multicenter clinical trial.

PubMed

Nazarov, Vladimir M; Zheleznev, Sergey I; Bogachev-Prokophiev, Alexandr V; Afanasyev, Alexandr V; Nemchenko, Eugene V; Jeltovskiy, Yuri V; Lavinyukov, Sergey O

2014-01-01

Prosthesis choice is a major concern in valvular surgery. A multicenter clinical trial was performed to assess the efficacy and safety of the CardiaMed prosthetic heart valve. The study enrolled 420 patients who underwent mitral (209) or aortic (211) valve replacement from 2003 to 2004 at 7 institutions in Russia, and who were followed up from 2006 to 2011. The mean age was 52.2 ± 10.2 years (range, 12-78 years), 47.4% were female, and 99.05% completed the study. The maximum observation term was 7.5 years (2188.5 patient-years); 1081.6 patient-years for aortic and 1106.9 patient-years for mitral valve replacement. The overall 7-year survival rate was 85.1%  ± 3.7%; 86.1%  ± 4.8% and 84.4%  ± 5.4% for aortic and mitral valve replacement, respectively. The 7-year freedom from valve-related death was 93.9%  ± 3.7% and 94.5%  ± 3.2% for aortic and mitral valve replacement, respectively. When early mortality (<30 days) was excluded, these rates were 94.8%  ± 3.1% and 93.8%  ± 3.82%, respectively. Linearized valve-dependent complication rates were determined for structural valve failure (0%/patient-year overall), thrombosis (0.63%/patient-year, all for mitral valve replacement), thromboembolic complications including transient neurologic deficits (0.13%/patient-year overall, 0.5%/patient-year for aortic valve replacement, 0.8%/patient-year for mitral valve replacement), hemorrhagic bleeding (0.64%/patient-year overall, 0.55%/patient-year for aortic valve replacement, 0.09%/patient-year for mitral valve replacement), prosthetic endocarditis (0.28%/patient-year overall, 0.28%/patient-year for aortic valve replacement, 0%/patient-year for mitral valve replacement), and hemolysis (0%/patient-year overall). The CardiaMed mechanical heart valve prostheses meets world standards of safety and efficacy.

19. On salon deck level, view looking forward at tops ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. On salon deck level, view looking forward at tops of steam chimneys (rising from boilers) showing safety valves, safety valve vent pipe, and smoke bonnet underneath smokestack. Steam chimneys are integral parts of the boilers and in effect are smokestacks surrounded by a pressurized steam space continuous with the boiler steam spaces. - Ferry TICONDEROGA, Route 7, Shelburne, Chittenden County, VT

JenaValve.

PubMed

Treede, Hendrik; Rastan, Ardawan; Ferrari, Markus; Ensminger, Stephan; Figulla, Hans-Reiner; Mohr, Friedrich-Wilhelm

2012-09-01

The JenaValve is a next-generation TAVI device which consists of a well-proven porcine root valve mounted on a low-profile nitinol stent. Feeler guided positioning and clip fixation on the diseased leaflets allow for anatomically correct implantation of the device without rapid pacing. Safety and efficacy of transapical aortic valve implantation using the JenaValve were evaluated in a multicentre prospective study that showed good short and midterm results. The valve was CE-mark released in Europe in September 2011. A post-market registry ensures on-going and prospective data collection in "real-world" patients. The transfemoral JenaValve delivery system will be evaluated in a first-in-man study in the near future.

Propellant actuated nuclear reactor steam depressurization valve

DOEpatents

Ehrke, Alan C.; Knepp, John B.; Skoda, George I.

1992-01-01

A nuclear fission reactor combined with a propellant actuated depressurization and/or water injection valve is disclosed. The depressurization valve releases pressure from a water cooled, steam producing nuclear reactor when required to insure the safety of the reactor. Depressurization of the reactor pressure vessel enables gravity feeding of supplementary coolant water through the water injection valve to the reactor pressure vessel to prevent damage to the fuel core.

View forward from bulkhead no. 38 of compartment B126 crew ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View forward from bulkhead no. 38 of compartment B-126 crew space. Note stop valves on bulkhead at right side of photograph; these steam control valves allowed remote activation of the main, auxiliary and safety valves for the port engine in the event that the engine room valves were disabled or unreachable. (044) - USS Olympia, Penn's Landing, 211 South Columbus Boulevard, Philadelphia, Philadelphia County, PA

Valve in valve transcatheter aortic valve implantation (ViV-TAVI) versus redo-Surgical aortic valve replacement (redo-SAVR): A systematic review and meta-analysis.

PubMed

Nalluri, Nikhil; Atti, Varunsiri; Munir, Abdullah B; Karam, Boutros; Patel, Nileshkumar J; Kumar, Varun; Vemula, Praveen; Edla, Sushruth; Asti, Deepak; Paturu, Amrutha; Gayam, Sriramya; Spagnola, Jonathan; Barsoum, Emad; Maniatis, Gregory A; Tamburrino, Frank; Kandov, Ruben; Lafferty, James; Kliger, Chad

2018-05-20

Bioprosthetic (BP) valves have been increasingly used for aortic valve replacement over the last decade. Due to their limited durability, patients presenting with failed BP valves are rising. Valve in Valve - Transcatheter Aortic Valve Implantation (ViV-TAVI) emerged as an alternative to the gold standard redo-Surgical Aortic Valve Replacement (redo-SAVR). However, the utility of ViV-TAVI is poorly understood. A systematic electronic search of the scientific literature was done in PubMed, EMBASE, SCOPUS, Google Scholar, and ClinicalTrials.gov. Only studies which compared the safety and efficacy of ViV-TAVI and redo-SAVR head to head in failed BP valves were included. Six observational studies were eligible and included 594 patients, of whom 255 underwent ViV- TAVI and 339 underwent redo-SAVR. There was no significant difference between ViV-TAVI and redo- SAVR for procedural, 30 day and 1 year mortality rates. ViV-TAVI was associated with lower risk of permanent pacemaker implantation (PPI) (OR: 0.43, CI: 0.21-0.89; P = 0.02) and a trend toward increased risk of paravalvular leak (PVL) (OR: 5.45, CI: 0.94-31.58; P = 0.06). There was no significant difference for stroke, major bleeding, vascular complications and postprocedural aortic valvular gradients more than 20 mm-hg. Our results reiterate the safety and feasibility of ViV-TAVI for failed aortic BP valves in patients deemed to be at high risk for surgery. VIV-TAVI was associated with lower risk of permanent pacemaker implantation with a trend toward increased risk of paravalvular leak. © 2018, Wiley Periodicals, Inc.

46 CFR 151.50-31 - Chlorine.

Code of Federal Regulations, 2010 CFR

2010-10-01

... inside diameter manhole, fitted with a cover located above the maximum liquid level and as close as... accessary equipment shall be of a type suitable for use with chlorine and shall be made of metal, corrosion... shutoff valves and with safety relief valves. All valves shall be bolted to the cover or covers specified...

Development of a fast valve for mitigating disruptions in tokamaks

NASA Astrophysics Data System (ADS)

Savtchkov, A.; Finken, K. H.; Mank, G.

2002-10-01

In support of our disruption mitigation profram, a fast gas valve has been constructed and tested on TEXTOR at FZJ Juelich. Its main features have been shown to be: (1) rapid response time: 0.5 ms; (2) amount of injected gas: variable, 2-1000 mbar×l; (3) linear dependence of the number of injected particles on the gas pressure; (4) capability of working in a strong magnetic field; (5) sort of gas: any. The valve has the standard CF 35 flange, commonly used in vacuum engineering. All the components that have contact with vacuum were made of stainless steel, except for the closing aluminum piston. To prevent gas leaking directly from the bottles to the experimental vessel there are also two safety valves, closing the bottles before the shot. The required control equipment includes a high power supply and the combined controller for the safety valves and baratrons, both being able to work with TTL control signals. During tests and experiments on TEXTOR and ASDEX-Upgrade, the valve showed successful operation with three gas types: He, Ne, Ar.

Primary cooling check valve steam generator and loose parts events of November 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1985-12-23

On November 10, 1985, a primary coolant check valve, CV-3-8, was opened for inspection. The valve flapper and mounting bracket were found to have become detached from the valve body and were resting in the bottom of the valve. Normally, the bracket is secured to the valve body with three studs and nuts. All three sets of studs, nuts and stud retainers were missing. As part of the effort to locate the missing valve parts, the primary side of the No. 2A steam generator was opened for inspection. Three cap screws and an associated locking bar used to secure certainmore » internals were found to be missing. In response, the Director, Reactor Engineering Department was assigned lead responsibility for developing and directing the implementation of a plan to correct deficiencies and ready the plant to return to operation. Next, a Special Safety Assessment Team was established to provide a structured assessment of the safety aspect of the component failures and the implications of such failures to other components in the primary coolant system. This structured assessment was to result in the development of an action plan that included the development of specific safety criteria, and identification and conduct of special investigations and analyses required for recovery from the event. Finally, an independent Management Review Team was created. The purpose of this report is to document the work of the Management Review Team, including the causal factors analyses, and various reviews required to support the recovery process.« less

Surface and subsurface inspection of food safety and quality using a line-scan Raman system

USDA-ARS?s Scientific Manuscript database

This paper presents a line-scan Raman platform for food safety and quality research, which can be configured for Raman chemical imaging (RCI) mode for surface inspection and spatially offset Raman spectroscopy (SORS) mode for subsurface inspection. In the RCI mode, macro-scale imaging was achieved u...

Safety and Efficacy of Transcatheter Aortic Valve Replacement in the Treatment of Pure Aortic Regurgitation in Native Valves and Failing Surgical Bioprostheses: Results From an International Registry Study.

PubMed

Sawaya, Fadi J; Deutsch, Marcus-André; Seiffert, Moritz; Yoon, Sung-Han; Codner, Pablo; Wickramarachchi, Upul; Latib, Azeem; Petronio, A Sonia; Rodés-Cabau, Josep; Taramasso, Maurizio; Spaziano, Marco; Bosmans, Johan; Biasco, Luigi; Mylotte, Darren; Savontaus, Mikko; Gheeraert, Peter; Chan, Jason; Jørgensen, Troels H; Sievert, Horst; Mocetti, Marco; Lefèvre, Thierry; Maisano, Francesco; Mangieri, Antonio; Hildick-Smith, David; Kornowski, Ran; Makkar, Raj; Bleiziffer, Sabine; Søndergaard, Lars; De Backer, Ole

2017-05-22

The aim of this study was to evaluate the use of transcatheter heart valves (THV) for the treatment of noncalcific pure native aortic valve regurgitation (NAVR) and failing bioprosthetic surgical heart valves (SHVs) with pure severe aortic regurgitation (AR). Limited data are available about the "off-label" use of transcatheter aortic valve replacement (TAVR) to treat pure severe AR. The study population consisted of patients with pure severe AR treated by TAVR at 18 different centers. Study endpoints were device success, early safety, and clinical efficacy at 30 days, as defined by Valve Academic Research Consortium 2 criteria. A total of 146 patients were included, 78 patients in the NAVR group and 68 patients in the failing SHV group. In the NAVR group, device success, early safety, and clinical efficacy were 72%, 66%, and 61%, respectively. Device success and clinical efficacy were significantly better with newer generation THVs compared with old-generation THVs (85% vs. 54% and 75% vs. 46%, respectively, p < 0.05); this was mainly due to less second THV implantations and a lower rate of moderate to severe paravalvular regurgitation (10% vs. 24% and 3% vs. 27%, respectively). Independent predictors of 30-day mortality were body mass index <20 kg/m 2 , STS surgical risk score >8%, major vascular or access complication, and moderate to severe AR. In the failing SHV group, device success, early safety, and clinical efficacy were 71%, 90%, and 77%, respectively. TAVR for pure NAVR remains a challenging condition, with old-generation THVs being associated with THV embolization and migration and significant paravalvular regurgitation. Newer generation THVs show more promising outcomes. For those patients with severe AR due to failing SHVs, TAVR is a valuable therapeutic option. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Refuge alternatives relief valve testing and design with updated test stand

PubMed Central

Lutz, T.J.; Bissert, P.T.; Homce, G.T.; Yonkey, J.A.

2018-01-01

Underground refuge alternatives require an air source to supply breathable air to the occupants. This requires pressure relief valves to prevent unsafe pressures from building up within the refuge alternative. The U.S. Mine Safety and Health Administration (MSHA) mandates that pressure relief valves prevent pressure from exceeding 1.25 kPa (0.18 psi), or as specified by the manufacturer, above mine atmospheric pressure when a fan or compressor is used for the air supply. The U.S. National Institute for Occupational Safety and Health (NIOSH) tested a variety of pressure relief valves using an instrumented test fixture consisting of data acquisition equipment, a centrifugal blower, ductwork and various sensors to determine if the subject pressure relief valves meet the MSHA requirement. Relief pressures and flow characteristics, including opening pressure and flow rate, were measured for five different pressure relief valves under a variety of conditions. The subject pressure relief valves included two off-the-shelf modified check valves, two check valves used in MSHA-approved built-in-place refuge alternatives, and a commercially available valve that was designed for a steel refuge alternative and is currently being used in some built-in-place refuge alternatives. The test results showed relief pressures ranging from 0.20 to 1.53 kPa (0.03 to 0.22 psi) and flow rates up to 19.3 m3/min (683 scfm). As tested, some of the pressure relief valves did not meet the 1.25 kPa (0.18 psi) relief specification. PMID:29563650

49 CFR 192.365 - Service lines: Location of valves.

Code of Federal Regulations, 2010 CFR

2010-10-01

... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Customer Meters, Service Regulators... accessible location that, if feasible, is outside of the building. (c) Underground valves. Each underground...

Process and apparatus for obtaining samples of liquid and gas from soil

DOEpatents

Rossabi, J.; May, C.P.; Pemberton, B.E.; Shinn, J.; Sprague, K.

1999-03-30

An apparatus and process for obtaining samples of liquid and gas from subsurface soil is provided having filter zone adjacent an external expander ring. The expander ring creates a void within the soil substrate which encourages the accumulation of soil-borne fluids. The fluids migrate along a pressure gradient through a plurality of filters before entering a first chamber. A one-way valve regulates the flow of fluid into a second chamber in further communication with a collection tube through which samples are collected at the surface. A second one-way valve having a reverse flow provides additional communication between the chambers for the pressurized cleaning and back-flushing of the apparatus. 8 figs.

Process and apparatus for obtaining samples of liquid and gas from soil

DOEpatents

Rossabi, Joseph; May, Christopher P.; Pemberton, Bradley E.; Shinn, Jim; Sprague, Keith

1999-01-01

An apparatus and process for obtaining samples of liquid and gas from subsurface soil is provided having filter zone adjacent an external expander ring. The expander ring creates a void within the soil substrate which encourages the accumulation of soil-borne fluids. The fluids migrate along a pressure gradient through a plurality of filters before entering a first chamber. A one-way valve regulates the flow of fluid into a second chamber in further communication with a collection tube through which samples are collected at the surface. A second one-way valve having a reverse flow provides additional communication between the chambers for the pressurized cleaning and back-flushing of the apparatus.

Evaluating the Performance of the NASA LaRC CMF Motion Base Safety Devices

NASA Technical Reports Server (NTRS)

Gupton, Lawrence E.; Bryant, Richard B., Jr.; Carrelli, David J.

2006-01-01

This paper describes the initial measured performance results of the previously documented NASA Langley Research Center (LaRC) Cockpit Motion Facility (CMF) motion base hardware safety devices. These safety systems are required to prevent excessive accelerations that could injure personnel and damage simulator cockpits or the motion base structure. Excessive accelerations may be caused by erroneous commands or hardware failures driving an actuator to the end of its travel at high velocity, stepping a servo valve, or instantly reversing servo direction. Such commands may result from single order failures of electrical or hydraulic components within the control system itself, or from aggressive or improper cueing commands from the host simulation computer. The safety systems must mitigate these high acceleration events while minimizing the negative performance impacts. The system accomplishes this by controlling the rate of change of valve signals to limit excessive commanded accelerations. It also aids hydraulic cushion performance by limiting valve command authority as the actuator approaches its end of travel. The design takes advantage of inherent motion base hydraulic characteristics to implement all safety features using hardware only solutions.

46 CFR 154.540 - Quick-closing shut-off valves: Emergency shut-down system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... BULK DANGEROUS CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design... emergency shut-down system that: (a) Closes all the valves; (b) Is actuated by a single control in at least two locations remote from the quick-closing valves; (c) Is actuated by a single control in each cargo...

46 CFR 154.540 - Quick-closing shut-off valves: Emergency shut-down system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... BULK DANGEROUS CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design... emergency shut-down system that: (a) Closes all the valves; (b) Is actuated by a single control in at least two locations remote from the quick-closing valves; (c) Is actuated by a single control in each cargo...

10 CFR 39.45 - Subsurface tracer studies.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Subsurface tracer studies. 39.45 Section 39.45 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Equipment § 39.45 Subsurface tracer studies. (a) The licensee shall require all personnel handling radioactive...

10 CFR 39.45 - Subsurface tracer studies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Subsurface tracer studies. 39.45 Section 39.45 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Equipment § 39.45 Subsurface tracer studies. (a) The licensee shall require all personnel handling radioactive...

Thermal overload protection for electric motors on safety-related motor-operated valves: Generic Issue II. E. 6. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rothberg, O.

1988-06-01

NRC regulatory positions, as stated in Regulatory Guide 1.106, Revision 1, have been identified by the Office for Analysis and Evaluation of Operational Data (AEOD) as potential contributors to valve motor burnout. AEOD is particularly concerned about the allowed policy of bypassing thermal overload devices during normal or accident conditions. Regulatory Guide 1.106 favors compromising the function of thermal overload devices in favor of completing the safety-related action of valves. The purpose of this study was to determine if the guidance contained in Regulatory Guide 1.106 is appropriate and, if not, to recommend the necessary changes. This report describes thermalmore » overload devices commonly used to protect safety-related valve operator motors. The regulatory guidelines stated in Regulatory Guide 1.106 along with the limitations of thermal overload protection are discussed. Supplements and alternatives to thermal overload protection are also described. Findings and conclusions of several AEOD reports are discussed. Information obtained from the standard review plan, standard technical specifications, technical specifications from representative plants, and several papers are cited.« less

42 CFR 84.137 - Inhalation and exhalation valves; check valves; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY... constructed to allow airflow toward the facepiece only shall be provided in the connections to the facepiece...

42 CFR 84.137 - Inhalation and exhalation valves; check valves; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY... constructed to allow airflow toward the facepiece only shall be provided in the connections to the facepiece...

46 CFR 38.20-1 - Venting-T/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... pressure of 10 percent of the relief valve setting is insufficient to move the gases through any but an...) Vents and headers shall be so installed as to prevent excessive stresses on safety relief valve...

46 CFR 38.20-1 - Venting-T/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

... pressure of 10 percent of the relief valve setting is insufficient to move the gases through any but an...) Vents and headers shall be so installed as to prevent excessive stresses on safety relief valve...

46 CFR 38.20-1 - Venting-T/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... pressure of 10 percent of the relief valve setting is insufficient to move the gases through any but an...) Vents and headers shall be so installed as to prevent excessive stresses on safety relief valve...

46 CFR 38.20-1 - Venting-T/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... pressure of 10 percent of the relief valve setting is insufficient to move the gases through any but an...) Vents and headers shall be so installed as to prevent excessive stresses on safety relief valve...

46 CFR 38.20-1 - Venting-T/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

... pressure of 10 percent of the relief valve setting is insufficient to move the gases through any but an...) Vents and headers shall be so installed as to prevent excessive stresses on safety relief valve...

30 CFR 250.801 - Subsurface safety devices.

Code of Federal Regulations, 2012 CFR

2012-07-01

... permafrost, unstable bottom conditions, hydrate formation, or paraffins, an alternate setting depth of the... such as permafrost, unstable bottom conditions, hydrate formations, and paraffins. (g) Subsurface...

30 CFR 250.801 - Subsurface safety devices.

Code of Federal Regulations, 2013 CFR

2013-07-01

... permafrost, unstable bottom conditions, hydrate formation, or paraffins, an alternate setting depth of the... such as permafrost, unstable bottom conditions, hydrate formations, and paraffins. (g) Subsurface...

30 CFR 250.801 - Subsurface safety devices.

Code of Federal Regulations, 2014 CFR

2014-07-01

... permafrost, unstable bottom conditions, hydrate formation, or paraffins, an alternate setting depth of the... such as permafrost, unstable bottom conditions, hydrate formations, and paraffins. (g) Subsurface...

The challenge of valve-in-valve procedures in degenerated Mitroflow bioprostheses and the advantage of using the JenaValve transcatheter heart valve.

PubMed

Conradi, Lenard; Kloth, Benjamin; Seiffert, Moritz; Schirmer, Johannes; Koschyk, Dietmar; Blankenberg, Stefan; Reichenspurner, Hermann; Diemert, Patrick; Treede, Hendrik

2014-12-01

Recently, the feasibility of valve-in-valve procedures using current first-generation transcatheter heart valves (THV) in cases of structural valve degeneration has been reported as an alternative to conventional open repeat valve replacement. By design, certain biological valve xenografts carry a high risk of coronary ostia occlusion due to lateral displacement of leaflets after valve-in-valve procedures. In the present report we aimed to prove feasibility and safety of transapical valve-in-valve implantation of the JenaValve THV in two cases of degenerated Mitroflow bioprostheses. We herein report two cases of successful transapical valve-in-valve procedures using a JenaValve THV implanted in Sorin Mitroflow bioprostheses for structural valve degeneration. Both patients were alive and in good clinical condition at 30 days from the procedure. However, increased transvalvular gradients were noted in both cases. Transcatheter valve-in-valve implantation of a JenaValve THV is a valid alternative for patients with degenerated Mitroflow bioprostheses of sufficient size and in the presence of short distances to the coronary ostia who are too ill for conventional repeat open heart surgery. Increased pressure gradients have to be expected and weighed against the disadvantages of other treatment options when planning such a procedure.

Catheter Ablation of Focal Atrial Tachycardia Using Remote Magnetic Navigation.

PubMed

Webster, Mark; Pasupati, Sanjeevan; Lever, Nigel; Stiles, Martin

2018-05-01

This first-in-human study evaluated the safety and technical feasibility of the Tempo temporary cardiac pacing lead (BioTrace Medical), which includes a novel fixation mechanism and soft tip. Complications of temporary pacing leads include dislodgment, arrhythmias, and ventricular perforation. Temporary pacing applications have increased with transcatheter aortic valve replacement (TAVR) growth, for rapid pacing during balloon valvuloplasty (BAV) and valve deployment, and for periprocedural bradyarrhythmia support. Eligible patients required temporary pacing for TAVR, BAV, or electrophysiology (EP) procedures. Transthoracic echocardiograms were obtained at baseline and 24 hours after lead removal. Safety was defined as freedom from pericardial effusion requiring intervention or evidence of tamponade. Technical feasibility involved successful intracardiac delivery and pace capture. Additional evaluations included pacing threshold (PCT), rapid pacing, dislodgment, or sustained ventricular arrhythmias. Follow-up was to 30 days. Twenty-five patients (60% female; mean age, 64 ± 19 years) underwent 13 TAVRs (7 Sapien 3 valves [Edwards Lifesciences], 4 CoreValves [Medtronic], and 2 Lotus valves [Boston Scientific]), 11 EP procedures, and 1 BAV at two New Zealand centers from January 2016 to June 2016. Safety was met in all patients, with no device-related adverse events. Technical feasibility was achieved in 23 cases (92%); 2 patients had unsuitable anatomy. No patient had lead dislodgment or sustained ventricular arrhythmias, and the final procedural PCT was 0.7 ± 0.5 mA. Rapid pacing was successful in all cases. Five patients had successful postprocedural use up to 5 days. This first-in-human study demonstrates the safety and technical feasibility of the Tempo lead, providing stable periprocedural temporary pacing support.

Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery.

PubMed

Popma, Jeffrey J; Adams, David H; Reardon, Michael J; Yakubov, Steven J; Kleiman, Neal S; Heimansohn, David; Hermiller, James; Hughes, G Chad; Harrison, J Kevin; Coselli, Joseph; Diez, Jose; Kafi, Ali; Schreiber, Theodore; Gleason, Thomas G; Conte, John; Buchbinder, Maurice; Deeb, G Michael; Carabello, Blasé; Serruys, Patrick W; Chenoweth, Sharla; Oh, Jae K

2014-05-20

This study sought to evaluate the safety and efficacy of the CoreValve transcatheter heart valve (THV) for the treatment of severe aortic stenosis in patients at extreme risk for surgery. Untreated severe aortic stenosis is a progressive disease with a poor prognosis. Transcatheter aortic valve replacement (TAVR) with a self-expanding bioprosthesis is a potentially effective therapy. We performed a prospective, multicenter, nonrandomized investigation evaluating the safety and efficacy of self-expanding TAVR in patients with symptomatic severe aortic stenosis with prohibitive risks for surgery. The primary endpoint was a composite of all-cause mortality or major stroke at 12 months, which was compared with a pre-specified objective performance goal (OPG). A total of 41 sites in the United States recruited 506 patients, of whom 489 underwent attempted treatment with the CoreValve THV. The rate of all-cause mortality or major stroke at 12 months was 26.0% (upper 2-sided 95% confidence bound: 29.9%) versus 43.0% with the OPG (p < 0.0001). Individual 30-day and 12-month events included all-cause mortality (8.4% and 24.3%, respectively) and major stroke (2.3% and 4.3%, respectively). Procedural events at 30 days included life-threatening/disabling bleeding (12.7%), major vascular complications (8.2%), and need for permanent pacemaker placement (21.6%). The frequency of moderate or severe paravalvular aortic regurgitation was lower 12 months after self-expanding TAVR (4.2%) than at discharge (10.7%; p = 0.004 for paired analysis). TAVR with a self-expanding bioprosthesis was safe and effective in patients with symptomatic severe aortic stenosis at prohibitive risk for surgical valve replacement. (Safety and Efficacy Study of the Medtronic CoreValve System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement; NCT01240902). Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

46 CFR 56.50-25 - Safety and relief valve escape piping.

Code of Federal Regulations, 2012 CFR

2012-10-01

... discharging thereto and shall be led as near vertically as practicable to the atmosphere. (b) Expansion joints... valve discharges, when permitted to terminate in the machinery space, shall be led below the floorplates...

46 CFR 56.50-25 - Safety and relief valve escape piping.

Code of Federal Regulations, 2011 CFR

2011-10-01

... discharging thereto and shall be led as near vertically as practicable to the atmosphere. (b) Expansion joints... valve discharges, when permitted to terminate in the machinery space, shall be led below the floorplates...

46 CFR 56.50-25 - Safety and relief valve escape piping.

Code of Federal Regulations, 2014 CFR

2014-10-01

... discharging thereto and shall be led as near vertically as practicable to the atmosphere. (b) Expansion joints... valve discharges, when permitted to terminate in the machinery space, shall be led below the floorplates...

46 CFR 56.50-25 - Safety and relief valve escape piping.

Code of Federal Regulations, 2013 CFR

2013-10-01

... discharging thereto and shall be led as near vertically as practicable to the atmosphere. (b) Expansion joints... valve discharges, when permitted to terminate in the machinery space, shall be led below the floorplates...

The safety of tracheostomy speaking valve use during sleep in children: a pilot study.

PubMed

Barraza, Giselle Y; Fernandez, Claudia; Halaby, Claudia; Ambrosio, Sara; Simpser, Edwin F; Pirzada, Melodi B

2014-01-01

One of the disadvantages of having a tracheostomy tube is not being able to vocalize. A speaking valve connected to a tracheostomy tube allows patients to vocalize. Some studies have shown that tracheostomy-speaking valve can improve swallowing, respiratory secretion management, and expedite decannulation. There is scant research about speaking valve use during sleep. The aim of this study is to evaluate the safety of tracheostomy-speaking valve overnight, during sleep. Children, ages 1-18 years, with tracheostomy tubes who were using a tracheostomy-speaking valve during daytime/awake periods, were included in this study. The subjects had baseline monitoring of their heart rate, respiratory rate, oxygen saturation, and end tidal carbon dioxide measurement the night prior to the intervention, throughout the night at scheduled intervals. The tracheostomy-speaking valve was placed the following night and the same parameters were monitored and recorded throughout the study night. A total of 9 patients were recruited. In all subjects, the mean values of the overnight parameters showed no significant clinical variations between the baseline night and the study night. Repeated measure ANOVA analysis revealed no significant changes in the parameters over the 8 hours of recorded time. No major adverse events were recorded during the study night. This pilot study reveals that use of a tracheostomy-speaking valve during sleep, was not associated with adverse cardiopulmonary events. This is the first study to show that a tracheostomy-speaking valve might be safely used during sleep, in children. Copyright © 2014 Elsevier Inc. All rights reserved.

Refuge alternatives relief valve testing and design

PubMed Central

Lutz, T.J.; Bissert, P.T.; Homce, G.T.; Yonkey, J.A.

2016-01-01

The U.S. National Institute for Occupational Safety and Health (NIOSH) has been researching refuge alternatives (RAs) since 2007. RAs typically have built-in pressure relief valves (PRVs) to prevent the unit from reaching unsafe pressures. The U.S. Mine Safety and Health Administration requires that these valves vent the chamber at a maximum pressure of 1.25 kPa (0.18 psi, 5.0 in. H2O), or as specified by the manufacturer, above mine atmospheric pressure in the RA. To facilitate PRV testing, an instrumented benchtop test fixture was developed using an off-the-shelf centrifugal blower and ductwork. Relief pressures and flow characteristics were measured for three units: (1) a modified polyvinyl chloride check valve, (2) an off-the-shelf brass/cast-iron butterfly check valve and (3) a commercially available valve that was designed specifically for one manufacturer’s steel prefabricated RAs and had been adapted for use in one mine operator’s built-in-place RA. PRVs used in tent-style RAs were not investigated. The units were tested with different modifications and configurations in order to check compliance with Title 30 Code of Federal Regulations, or 30 CFR, regulations. The commercially available relief valve did not meet the 30 CFR relief pressure specification but may meet the manufacturer’s specification. Alternative valve designs were modified to meet the 30 CFR relief pressure specification, but all valve designs will need further design research to examine survivability in the event of a 103 kPa (15.0 psi) impulse overpressure during a disaster. PMID:28018003

Excess flow valve benefit/cost analysis.

DOT National Transportation Integrated Search

1994-12-31

The Office of Pipeline Safety (OPS) is adopting regulations requiring the installation of Excess Flow Valves (EFVs) on all new or renewed single-family residential gas services that operate at pressures that are always 10 psig (pounds per square inch...

Statistical Performance Evaluation Of Soft Seat Pressure Relief Valves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, Stephen P.; Gross, Robert E.

2013-03-26

Risk-based inspection methods enable estimation of the probability of failure on demand for spring-operated pressure relief valves at the United States Department of Energy's Savannah River Site in Aiken, South Carolina. This paper presents a statistical performance evaluation of soft seat spring operated pressure relief valves. These pressure relief valves are typically smaller and of lower cost than hard seat (metal to metal) pressure relief valves and can provide substantial cost savings in fluid service applications (air, gas, liquid, and steam) providing that probability of failure on demand (the probability that the pressure relief valve fails to perform its intendedmore » safety function during a potentially dangerous over pressurization) is at least as good as that for hard seat valves. The research in this paper shows that the proportion of soft seat spring operated pressure relief valves failing is the same or less than that of hard seat valves, and that for failed valves, soft seat valves typically have failure ratios of proof test pressure to set pressure less than that of hard seat valves.« less

77 FR 19414 - Pipeline Safety: Public Comment on Leak and Valve Studies Mandated by the Pipeline Safety...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID... Safety, Regulatory Certainty, and Job Creation Act of 2011 AGENCY: Pipeline and Hazardous Materials... Transportation (DOT), Pipeline and Hazardous Materials Safety Administration (PHMSA) is providing an important...

Remotely controlled valves on interstate natural gas pipelines : September 1999.

DOT National Transportation Integrated Search

1999-09-01

This report is in response to a Congressional mandate in the : Accountable Pipeline Safety and Partnership Act of 1996 to survey : and assess the effectiveness of remotely controlled valves (RCVs) : on interstate natural gas pipelines and to determin...

Chemical Safety Alert: Shaft Blow-Out Hazard of Check and Butterfly Valves

EPA Pesticide Factsheets

Certain types of check and butterfly valves can undergo shaft-disk separation and fail catastrophically, even when operated within their design limits of pressure and temperature, causing toxic/flammable gas releases, fires, and vapor cloud explosions.

Quality and Safety in Health Care, Part XXIX: The Transcatheter Valve Therapy Registry.

PubMed

Harolds, Jay A

2017-11-01

The American College of Cardiology, the Society of Thoracic Surgeons, and other organizations cooperated to form the Transcatheter Valve Therapy Registry. This registry studies information on the outcome of valve therapy device placement with a transcatheter approach. The companies that manufacture these devices can use the registry to meet the post-product sale surveillance requirements of the US Food and Drug Administration. There will also be linkage to the registry information from the Society of Thoracic Surgeons Adult Cardiac Surgery Database, which has information on open cardiac valve surgery.

46 CFR 154.532 - Valves: Cargo tank MARVS greater than 69 kPa gauge (10 psig).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Valves: Cargo tank MARVS greater than 69 kPa gauge (10... greater than 69 kPa gauge (10 psig). (a) Except connections for tank safety relief valves and except for... on a cargo tank with a MARVS greater than 69 kPa gauge (10 psig) must have, as close to the tank as...

System for the removal of contaminant soil-gas vapors

DOEpatents

Weidner, Jerry R.; Downs, Wayne C.; Kaser, Timothy G.; Hall, H. James

1997-01-01

A system extracts contaminated vapors from soil or other subsurface regions by using changes in barometric pressure to operate sensitive check valves that control air entry and removal from wells in the ground. The system creates an efficient subterranean flow of air through a contaminated soil plume and causes final extraction of the contaminants from the soil to ambient air above ground without any external energy sources.

System for the removal of contaminant soil-gas vapors

DOEpatents

Weidner, J.R.; Downs, W.C.; Kaser, T.G.; Hall, H.J.

1997-12-16

A system extracts contaminated vapors from soil or other subsurface regions by using changes in barometric pressure to operate sensitive check valves that control air entry and removal from wells in the ground. The system creates an efficient subterranean flow of air through a contaminated soil plume and causes final extraction of the contaminants from the soil to ambient air above ground without any external energy sources. 4 figs.

Transfemoral Implantation of a Fully Repositionable and Retrievable Transcatheter Valve for Noncalcified Pure Aortic Regurgitation.

PubMed

Schofer, Joachim; Nietlispach, Fabian; Bijuklic, Klaudija; Colombo, Antonio; Gatto, Fernando; De Marco, Federico; Mangieri, Antonio; Hansen, Lorenz; Bruschi, Giuseppe; Ruparelia, Neil; Rieß, Friedrich-Christian; Maisano, Franscesco; Latib, Azeem

2015-12-21

This study sought to evaluate the use of the Direct Flow Medical (DFM) transcatheter heart valve (Direct Flow Medical, Santa Rosa, California) for the treatment of noncalcific pure aortic regurgitation (AR). The treatment of noncalcific AR has remained a relative contraindication with transcatheter heart valves due to challenges in anchoring devices in the absence of calcium, concerns of valve embolization, and the high risk of significant residual paravalvular leak. The study population consisted of patients treated for severe noncalcific pure AR with transfemoral implantation of a DFM transcatheter heart valve at 6 European centers. The primary endpoint was the composite endpoint of device success and the secondary endpoint was the composite early safety endpoint (according to the VARC-2 criteria). Eleven high-risk (STS score 8.84 ± 8.9, Logistic EuroSCORE 19.9 ± 7.1) patients (mean age 74.7 ± 12.9 years) were included. Device success was achieved in all patients. In 1 patient, the initial valve prosthesis was retrieved after pull-through, and a second valve was successfully deployed. The early safety endpoint was reached in 91% of the patients, with 1 patient requiring surgical aortic valve replacement secondary to downward dislocation of the prosthesis that was successfully managed with surgical aortic valve replacement. DFM implantation resulted in excellent hemodynamics with none or trivial paravalvular regurgitation in 9 patients and a transprosthetic gradient of 7.7 ± 5.1 mm Hg at 30-day follow up. All patients derived symptomatic benefit following the procedure, with 72% in New York Heart Association functional class I or II. This study reports the feasibility of treating severe noncalcific AR with the Direct Flow prosthesis via the transfemoral route. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

North American trial results at 1 year with the Sorin Freedom SOLO pericardial aortic valve.

PubMed

Heimansohn, David; Roselli, Eric E; Thourani, Vinod H; Wang, Shaohua; Voisine, Pierre; Ye, Jian; Dabir, Reza; Moon, Michael

2016-02-01

A North American prospective, 15-centre Food and Drug Administration (FDA) valve trial was designed to assess the safety and effectiveness of the Freedom SOLO stentless pericardial aortic valve in the treatment of surgical aortic valve disease. Beginning in 2010, 251 patients (mean: 74.7 ± 7.5 years), were recruited in the Freedom SOLO aortic valve trial. One hundred eighty-nine patients have been followed for at least 1 year and are the basis for this review. Preoperatively, 54% of patients had NYHA functional class III or IV symptoms, and the majority of patients had a normal ejection fraction (EF) (median EF = 61%). Concomitant procedures were performed in 61.9% of patients, with coronary artery bypass grafting (CABG) (48.7%) being the most common followed by a MAZE procedure (13.7%). Reoperations were performed in 8.5% of patients in the study. The entire cohort of 251 patients enrolled had 7 deaths prior to 30 days, 2 of which were valve-related (aspiration pneumonia and sudden death) and 5 were not valve-related. There were 11 deaths after 30 days, 1 valve-related (unknown cardiac death) and 10 not valve-related. Five valves were explanted, 3 early (endocarditis, acute insufficiency and possible root dissection) and 2 late (endocarditis). Thirty-day adverse events include arrhythmias requiring permanent pacemaker (4.2%), thromboembolic events (3.7%) and thrombocytopenia (7.4%). One-year follow-up of all 189 patients demonstrated mean gradients for valve sizes 19, 21, 23, 25 and 27 mm of 11.7, 7.8, 6.3, 4.6 and 5.0 mmHg, respectively. Effective orifice areas for the same valve sizes were 1.2, 1.3, 1.6, 1.8 and 1.9 cm(2), respectively. Ninety-six percent of patients (181/189) were in NYHA class I or II at the 1-year follow-up. The Freedom SOLO stentless pericardial aortic valve demonstrated excellent haemodynamics and a good safety profile out to the 1 year of follow-up. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population*

PubMed Central

Liu, Xian-bao; Jiang, Ju-bo; Zhou, Qi-jing; Pu, Zhao-xia; He, Wei; Dong, Ai-qiang; Feng, Yan; Jiang, Jun; Sun, Yong; Xiang, Mei-xiang; He, Yu-xin; Fan, You-qi; Dong, Liang; Wang, Jian-an

2015-01-01

Objective: The purpose of this study is to evaluate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with a severe stenotic bicuspid aortic valve (BAV) in a Chinese population. While several groups have reported the feasibility, efficacy, and safety of TAVI for patients with a BAV, worldwide experience of the technique is still limited, especially in China. Methods: From March 2013 to November 2014, high surgical risk or inoperable patients with symptomatic severe aortic stenosis (AS) who had undergone TAVI at our institution were selected for inclusion in our study. Results were compared between a BAV group and a tricuspid aortic valve (TAV) group. Results: Forty patients were included in this study, 15 (37.5%) of whom were identified as having a BAV. In the BAV group, the aortic valve area was smaller ((0.47±0.13) vs. (0.59±0.14) cm2), the ascending aortic diameter was larger ((40.4±4.4) vs. (36.4±4.3) mm), and the concomitant aortic regurgitation was lower. No significant differences were found between the groups in the other baseline characteristics. No differences were observed either in the choice of access or valve size. The procedural success achieved in this study was 100%. There were no differences between groups in device success (86.7% vs. 88.0%), 30-d mortality (6.7% vs. 8.0%), or 30-d combined end point (13.3% vs. 12.0%). The incidences of new pacemaker implantation, paravalvular regurgitation and other complications, recovery of left ventricle ejection fraction and heart function were similar in both groups. Conclusions: Patients with a severely stenotic BAV can be treated with TAVI, and their condition after treatment should be similar to that of people with a TAV. PMID:25743122

49 CFR 179.400-19 - Valves and gages.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.400-19 Valves and gages...

30 CFR 250.1630 - Safety-system testing and records.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1630 Safety... components, and the following: (1) Safety relief valves on the natural gas feed system for power plant... source. (2) The following safety devices (excluding electronic pressure transmitters and level sensors...

Bioprosthetic Valve Fracture to Facilitate Transcatheter Valve-in-Valve Implantation.

PubMed

Allen, Keith B; Chhatriwalla, Adnan K; Cohen, David J; Saxon, John T; Aggarwal, Sanjeev; Hart, Anthony; Baron, Suzanne; Davis, J Russell; Pak, Alex F; Dvir, Danny; Borkon, A Michael

2017-11-01

Valve-in-valve transcatheter aortic valve replacement is less effective in small surgical bioprostheses. We evaluated the feasibility of bioprosthetic valve fracture with a high-pressure balloon to facilitate valve-in-valve transcatheter aortic valve replacement. In vitro bench testing on aortic tissue valves was performed on 19-mm and 21-mm Mitroflow (Sorin, Milan, Italy), Magna and Magna Ease (Edwards Lifesciences, Irvine, CA), Trifecta and Biocor Epic (St. Jude Medical, Minneapolis, MN), and Hancock II and Mosaic (Medtronic, Minneapolis, MN). High-pressure balloons Tru Dilation, Atlas Gold, and Dorado (C.R. Bard, Murray Hill, NJ) were used to determine which valves could be fractured and at what pressure fracture occurred. Mitroflow, Magna, Magna Ease, Mosaic, and Biocor Epic surgical valves were successfully fractured using high-pressures balloon 1 mm larger than the labeled valve size whereas Trifecta and Hancock II surgical valves could not be fractured. Only the internal valve frame was fractured, and the sewing cuff was never disrupted. Manufacturer's rated burst pressures for balloons were exceeded, with fracture pressures ranging from 8 to 24 atmospheres depending on the surgical valve. Testing further demonstrated that fracture facilitated the expansion of previously constrained, underexpanded transcatheter valves (both balloon and self-expanding) to the manufacturer's recommended size. Bench testing demonstrates that the frame of most, but not all, bioprosthetic surgical aortic valves can be fractured using high-pressure balloons. The safety of bioprosthetic valve fracture to optimize valve-in-valve transcatheter aortic valve replacement in small surgical valves requires further clinical investigation. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Successful use of a left ventricular apical access and closure device for second-generation transapical aortic valve implantation.

PubMed

Conradi, Lenard; Seiffert, Moritz; Shimamura, Kazuo; Schirmer, Johannes; Blankenberg, Stefan; Reichenspurner, Hermann; Diemert, Patrick; Treede, Hendrik

2014-09-01

Transcatheter aortic valve implantation (TAVI) has become routine for the treatment of high-risk patients with aortic stenosis. We assessed safety and feasibility of a left ventricular apical access and closure device combined with second-generation transapical (TA) TAVI transcatheter heart valves (THV). Three elderly, comorbid patients (logEuroSCORE I 13.0-31.1%) received transapical aortic valve implantation (TA-AVI) via the Apica ASC device (Apica Cardiovascular Ltd., Galway, Ireland) using second-generation THV (Medtronic Engager [Medtronic 3F Therapeutics, Santa Ana, California, United States], JenaValve [JenaValve Technology GmbH, Munich, Germany], Symetis Acurate [Symetis S.A., Ecublens, Switzerland]). Access was gained using a non-rib-spreading technique and a novel access and closure device. THV deployment was successful with excellent hemodynamic outcome (no PVL, n = 2; trace PVL, n = 1; mean transvalvular gradients, 5-19 mm Hg) and complete apical hemostasis. No periprocedural major adverse events occurred and Valve Academic Research Consortium-2-defined composite end point of device success was met in all cases. Safety and feasibility of TA-AVI using the ASC device with second-generation THV was demonstrated. Combining latest available technology is a major step toward improved functional outcome and decreased surgical trauma in TA-AVI. Potentially, technical enhancements may eventually pave the way toward a fully percutaneous TA-AVI procedure. Georg Thieme Verlag KG Stuttgart · New York.

Research on digital system design of nuclear power valve

NASA Astrophysics Data System (ADS)

Zhang, Xiaolong; Li, Yuan; Wang, Tao; Dai, Ye

2018-04-01

With the progress of China's nuclear power industry, nuclear power plant valve products is in a period of rapid development, high performance, low cost, short cycle of design requirements for nuclear power valve is proposed, so there is an urgent need for advanced digital design method and integrated design platform to provide technical support. Especially in the background of the nuclear power plant leakage in Japan, it is more practical to improve the design capability and product performance of the nuclear power valve. The finite element numerical analysis is a common and effective method for the development of nuclear power valves. Nuclear power valve has high safety, complexity of valve chamber and nonlinearity of seal joint surface. Therefore, it is urgent to establish accurate prediction models for earthquake prediction and seal failure to meet engineering accuracy and calculation conditions. In this paper, a general method of finite element modeling for nuclear power valve assembly and key components is presented, aiming at revealing the characteristics and rules of finite element modeling of nuclear power valves, and putting forward aprecision control strategy for finite element models for nuclear power valve characteristics analysis.

Navier-Stokes flow field analysis of compressible flow in a high pressure safety relief valve

NASA Technical Reports Server (NTRS)

Vu, Bruce; Wang, Ten-See; Shih, Ming-Hsin; Soni, Bharat

1993-01-01

The objective of this study is to investigate the complex three-dimensional flowfield of an oxygen safety pressure relieve valve during an incident, with a computational fluid dynamic (CFD) analysis. Specifically, the analysis will provide a flow pattern that would lead to the expansion of the eventual erosion pattern of the hardware, so as to combine it with other findings to piece together a most likely scenario for the investigation. The CFD model is a pressure based solver. An adaptive upwind difference scheme is employed for the spatial discretization, and a predictor, multiple corrector method is used for the velocity-pressure coupling. The computational result indicated vortices formation near the opening of the valve which matched the erosion pattern of the damaged hardware.

49 CFR 229.29 - Biennial tests.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Biennial tests. 229.29 Section 229.29..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Inspections and Tests § 229.29 Biennial tests. (a) Except for the valves and valve portions on non-MU locomotives that are cleaned, repaired...

42 CFR 84.1137 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Inhalation and exhalation valves; minimum requirements. 84.1137 Section 84.1137 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1137 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Inhalation and exhalation valves; minimum requirements. 84.1137 Section 84.1137 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1137 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Inhalation and exhalation valves; minimum requirements. 84.1137 Section 84.1137 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1137 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Inhalation and exhalation valves; minimum requirements. 84.1137 Section 84.1137 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1137 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Inhalation and exhalation valves; minimum requirements. 84.1137 Section 84.1137 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.120 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Inhalation and exhalation valves; minimum requirements. 84.120 Section 84.120 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.120 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Inhalation and exhalation valves; minimum requirements. 84.120 Section 84.120 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.120 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Inhalation and exhalation valves; minimum requirements. 84.120 Section 84.120 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.120 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Inhalation and exhalation valves; minimum requirements. 84.120 Section 84.120 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.84 - Hand-operated valves; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Hand-operated valves; minimum requirements. 84.84 Section 84.84 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.84 - Hand-operated valves; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Hand-operated valves; minimum requirements. 84.84 Section 84.84 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.84 - Hand-operated valves; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Hand-operated valves; minimum requirements. 84.84 Section 84.84 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.84 - Hand-operated valves; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Hand-operated valves; minimum requirements. 84.84 Section 84.84 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.84 - Hand-operated valves; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Hand-operated valves; minimum requirements. 84.84 Section 84.84 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.120 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Inhalation and exhalation valves; minimum requirements. 84.120 Section 84.120 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

Safety Assessment of TACOM’s Crew Station/Turret Motion Base Simulator

DTIC Science & Technology

1992-04-01

mode. The power ON switch is interlocked with the system hydraulic pressure switch so that the electronics can not be turned off while the system...analog) "o Oil Temperature Transducer (analog) "o Facility Pressure Switch o Pressure Critical Switch "o Six Supply Solenoid Valves "O Three Accumulator...Relief Solenoid Valves o Return Pressure Switch o Return Valve Switch o Six Filter Clogged Switches (one per filter) The Facility Pressure switch detects

Code of Safety for Fishermen and Fishing Vessels. Part B. Safety and Health Requirements for the Construction and Equipment of Fishing Vessels.

DTIC Science & Technology

1973-01-01

Committee of the Intergovernmental Maritime Con - sultative Organization (IMCO), an agency of the United Nations. In the course of these representations...han 1.8 m. In applying the fcrmula the actual GMo should be known to a sufficicnt degree of accuracy. If a rolling test, on inclining experiment...off oil fuel burners of boilers, fuel oil valves and air dampers should be so arranged that fuel oil inlet valves con bc opened only after air iulet

24 CFR 3280.704 - Fuel supply systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... temporarily, inside any manufactured home except for listed, completely self-contained hand torches, lanterns... the material to be used. (4) LP-gas container valves and accessories. (i) Valves in the assembly of a...) Systems mounted on the “A” frame assembly shall be so located that the discharge from the safety relief...

24 CFR 3280.704 - Fuel supply systems.

Code of Federal Regulations, 2011 CFR

2011-04-01

... temporarily, inside any manufactured home except for listed, completely self-contained hand torches, lanterns... the material to be used. (4) LP-gas container valves and accessories. (i) Valves in the assembly of a...) Systems mounted on the “A” frame assembly shall be so located that the discharge from the safety relief...

30 CFR 250.1625 - Blowout preventer system testing, records, and drills.

Code of Federal Regulations, 2011 CFR

2011-07-01

... drills. 250.1625 Section 250.1625 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND... SHELF Sulphur Operations § 250.1625 Blowout preventer system testing, records, and drills. (a) Prior to... manifold valves, upper and lower kelly cocks, and drill-string safety valves shall be pressure tested to...

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.77 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Inhalation and exhalation valves; minimum requirements. 84.77 Section 84.77 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.77 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Inhalation and exhalation valves; minimum requirements. 84.77 Section 84.77 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.123 - Exhalation valve leakage test.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Exhalation valve leakage test. 84.123 Section 84.123 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84...

42 CFR 84.123 - Exhalation valve leakage test.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Exhalation valve leakage test. 84.123 Section 84.123 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84...

42 CFR 84.77 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Inhalation and exhalation valves; minimum requirements. 84.77 Section 84.77 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.77 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Inhalation and exhalation valves; minimum requirements. 84.77 Section 84.77 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.123 - Exhalation valve leakage test.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Exhalation valve leakage test. 84.123 Section 84.123 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84...

42 CFR 84.123 - Exhalation valve leakage test.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Exhalation valve leakage test. 84.123 Section 84.123 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84...

42 CFR 84.77 - Inhalation and exhalation valves; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Inhalation and exhalation valves; minimum requirements. 84.77 Section 84.77 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.123 - Exhalation valve leakage test.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Exhalation valve leakage test. 84.123 Section 84.123 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84...

Chemical Safety Alert: Emergency Isolation for Hazardous Material Fluid Transfer Systems - Application and Limitations of Excess Flow Valves

EPA Pesticide Factsheets

While excess flow valves (EFV) are in extensive service and have prevented numerous pipe or hose breaks from becoming much more serious incidents, experience shows that in some cases the EFV did not perform as intended, usually because of misapplication.

49 CFR 232.103 - General requirements for all train brake systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... the air compressor governor starting or loading pressure. (l) Except as otherwise provided in this... brake pipe air pressure: Road Service 90 Switch Service 60 (2) Minimum differential between brake pipe and main reservoir air pressures, with brake valve in running position 15 (3) Safety valve for...

49 CFR 232.103 - General requirements for all train brake systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... the air compressor governor starting or loading pressure. (l) Except as otherwise provided in this... brake pipe air pressure: Road Service 90 Switch Service 60 (2) Minimum differential between brake pipe and main reservoir air pressures, with brake valve in running position 15 (3) Safety valve for...

76 FR 15814 - Airworthiness Directives; The Boeing Company Model 747 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... listed above. This AD requires measuring the electrical bond resistance between the motor operated valve... SNPRM proposed to require measuring the electrical bond resistance between the motor operated valve (MOV... the relevant data, considered the comment received, and determined that air safety and the public...

30 CFR 57.4201 - Inspection.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control...) Water pipes, valves, outlets, hydrants, and hoses that are part of the mine's firefighting system shall...

30 CFR 57.4201 - Inspection.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control...) Water pipes, valves, outlets, hydrants, and hoses that are part of the mine's firefighting system shall...

30 CFR 56.4201 - Inspection.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control...) Water pipes, valves, outlets, hydrants, and hoses that are part of the mine's firefighting system shall...

30 CFR 56.4201 - Inspection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control...) Water pipes, valves, outlets, hydrants, and hoses that are part of the mine's firefighting system shall...

30 CFR 57.4201 - Inspection.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control...) Water pipes, valves, outlets, hydrants, and hoses that are part of the mine's firefighting system shall...

30 CFR 57.4201 - Inspection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control...) Water pipes, valves, outlets, hydrants, and hoses that are part of the mine's firefighting system shall...

30 CFR 56.4201 - Inspection.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control...) Water pipes, valves, outlets, hydrants, and hoses that are part of the mine's firefighting system shall...

30 CFR 56.4201 - Inspection.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control...) Water pipes, valves, outlets, hydrants, and hoses that are part of the mine's firefighting system shall...

Endoscopic treatment of native lung hyperinflation using endobronchial valves in single-lung transplant patients: a multinational experience.

PubMed

Perch, Michael; Riise, Gerdt C; Hogarth, Kyle; Musani, Ali I; Springmeyer, Steven C; Gonzalez, Xavier; Iversen, Martin

2015-01-01

Hyperinflation of the native lung (NLH) is a known complication to single-lung transplantation for emphysema. The hyperinflation can lead to compression of the graft and cause respiratory failure. Endobronchial valves have been used to block airflow in specific parts of the native lung, reducing the native lung volume and relieving the graft. We report short-term follow-up and safety from 14 single-lung transplant patients with NLH treated with bronchoscopic lung volume reduction using endobronchial valves. Retrospective clinical information related to endobronchial valve treatment was obtained from four centres. All patients were treated with IBV(TM) Valve System (Spiration, Olympus Respiratory America, Redmond, WA, USA). All patients had evidence of severe NLH with mediastinal displacement. A total of 74 IBV valves were placed in 14 patients, with an average of 5.3 (range 2-10). Five patients had two procedures with staged treatment. Eleven patients reported symptom relief, and nine had lung function improvements. There was a significant increase in forced expiratory volume in 1 s of 9% (P = 0.013) and forced vital capacity of 15% (P = 0.034) within the first months after treatment. There were no reported device-related adverse events nor reports of migration. Two patients had pneumothorax. One patient had pneumonia in the location of the valve placement, and another had infection within days. Three other patients were hospitalised with infection 2 months after treatment. Treating NLH with IBV endobronchial valves leads to clinical improvement in the majority of patients, and the treatment has an acceptable safety. © 2014 John Wiley & Sons Ltd.

Valve leakage inspection, testing, and maintenance process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aikin, J.A.; Reinwald, J.W.

1989-01-01

Atomic Energy of Canada Limited-Research Company (AECL-RC), Chalk River, has more than 50 person-years dedicated toward the leak-free valve. In the early 1970s, the Chalk River Nuclear Laboratories (CRNL) developed valve stem live-loading and recently completed the packing tests for the Electric Power Research Institute (EPRI)-funded Valve Packing Improvement Study. Current safety concerns with asbestos-based valve packings and the difficulty in removing newer graphite packings prompted CRNL to investigate methods to improve valve repacking procedures. The present practice of valve packing replacement is very labor-intensive, requiring use of hand tools such as corkscrew devices and special packing picks. Use ofmore » water jets to cut or fragment the packing for withdrawal from the stuffing box does improve the process, but removal of the lantern or junk rings is still difficult. To address these problems, AECL-RC has developed a unique valve maintenance process designed to reduce person-rem exposures, the risk of scoring the stem or stuffing box, and maintenance costs and to improve the engineering quality of valve repair.« less

AAFES Gas Station at Creech Air Force Base Environmental Assessment

DTIC Science & Technology

2009-07-01

Creech AFB with modern fuel refilling services. The AAFES Gas Station would include a one pump two hose filling station, a concrete slab, a 12,000...at both end of each hose , a shear valve at the base of the pump, and an electronic sensor in the dispenser to detect fuel leakage. In order to add...designed and built with leak prevention safety equipment. Shut- off valves would be installed at both ends of each hose . A shear valve would be

Quality and Safety in Health Care, Part XXX: Transcatheter Aortic Valve Therapy.

PubMed

Harolds, Jay A

2017-12-01

Initially, the transcatheter aortic valve replacement procedure was approved only for patients with aortic stenosis that was both severe and symptomatic who either also had too high a risk of aortic valve replacement surgery to have the surgery or who had a high risk for the surgery. Between the years 2012 and 2015, the death rate at 30 days declined from an initial rate of 7.5% to 4.6%. There has also been more use of the transfemoral approach over the years. In 2016, the transcatheter aortic valve replacement was approved for patients with aortic stenosis at intermediate risk of surgery.

Fatal association of mechanical valve thrombosis with dabigatran: a report of two cases.

PubMed

Atar, Shaul; Wishniak, Alice; Shturman, Alexander; Shtiwi, Sewaed; Brezins, Marc

2013-07-01

Several new oral anticoagulants have been approved for thromboembolism prevention in patients with nonvalvular atrial fibrillation. However, they are not yet approved for anticoagulation use in patients with prosthetic mechanical valves, and no randomized data have been published so far on their safety of use in these patients. We present two cases of patients with prosthetic mechanical mitral valves who were switched from warfarin and acenocoumarol to dabigatran and within 1 month experienced severe valve complications resulting in death. One patient experienced stroke and later cardiogenic shock and death, and the other experienced pulmonary edema, cardiogenic shock, and subsequent death.

46 CFR 162.018-7 - Flow rating tests.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-7 Flow... the Commanding Officer, USCG Marine Safety Center. (b) [Reserved] [CGFR 68-82, 33 FR 18908, Dec. 18...

46 CFR 162.018-7 - Flow rating tests.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-7 Flow... the Commanding Officer, USCG Marine Safety Center. (b) [Reserved] [CGFR 68-82, 33 FR 18908, Dec. 18...

46 CFR 162.018-7 - Flow rating tests.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-7 Flow... the Commanding Officer, USCG Marine Safety Center. (b) [Reserved] [CGFR 68-82, 33 FR 18908, Dec. 18...

46 CFR 162.018-7 - Flow rating tests.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-7 Flow... the Commanding Officer, USCG Marine Safety Center. (b) [Reserved] [CGFR 68-82, 33 FR 18908, Dec. 18...

46 CFR 162.018-7 - Flow rating tests.

Code of Federal Regulations, 2013 CFR

2013-10-01

...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied Compressed Gas § 162.018-7 Flow... the Commanding Officer, USCG Marine Safety Center. (b) [Reserved] [CGFR 68-82, 33 FR 18908, Dec. 18...

Diver Operated Tools and Applications for Underwater Construction

DTIC Science & Technology

1987-01-01

subsurface construction. rhe list is by no means exhaustive and new 3 methods and requirements continue to evolve. * 8 I NCUAPTUN TIM DIVINO OPMATIONS...length suit that permitted the exhaust air to escape under the hem. By 1840, Siebe made a full length waterproof suit and added an exhaust valve to...The open circuit scuba takes 3 air from the supply tank, is inhaled by th& diver, and then exhausted directly to the surrounding water. 3 The basic

30 CFR 250.517 - Tubing and wellhead equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... evaluated every 30 days and the results submitted to the District Manager. (c) When the tree is installed..., a surface tubing head, a surface tubing hanger, and a surface christmas tree. (d) Wellhead, tree... and one surface safety valve, installed above the master valve, in the vertical run of the tree. (e...

49 CFR 195.428 - Overpressure safety devices and overfill protection systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... months, but at least twice each calendar year, inspect and test each pressure limiting device, relief... reliability of operation for the service in which it is used. (b) In the case of relief valves on pressure breakout tanks containing highly volatile liquids, each operator shall test each valve at intervals not...

30 CFR 250.447 - When must I pressure test the BOP system?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.447 When must I pressure... valves, inside BOP, and drill-string safety valve): (a) When installed; (b) Before 14 days have elapsed...

MRI safety of a programmable shunt assistant at 3 and 7 Tesla.

PubMed

Mirzayan, M Javad; Klinge, Petra M; Samii, Madjid; Goetz, Friedrich; Krauss, Joachim K

2012-06-01

Several new shunt technologies have been developed to optimize hydrocephalus treatment within the past few years. Overdrainage, however, still remains an unresolved problem. One new technology which may reduce the frequency of this complication is the use of a programmable shunt assistant (proSA). Inactive in a horizontal position, it impedes CSF flow in a vertical position according to a prescribed pressure level ranging from 0 to 40 cm H(2)O. We exposed the proSA valve in an ex vivo protocol to MR systems operating at 3 and 7 Tesla to investigate its MRI safety. Following 3 Tesla exposure, no changes in valve settings were noted. Adjustment to any pressure level was possible thereafter. The mean deflection angle was 23 ± 3°. After exposure to 7 Tesla, however, there were unintended pressure changes, and the mechanism for further adjustment of the valves even disintegrated. According to the results of this study, proSA is safe with heteropolar vertical magnet alignment at 3 Tesla. Following 7 Tesla exposure, the valves lost their functional capability.

Guide for Oxygen Component Qualification Tests

NASA Technical Reports Server (NTRS)

Bamford, Larry J.; Rucker, Michelle A.; Dobbin, Douglas

1996-01-01

Although oxygen is a chemically stable element, it is not shock sensitive, will not decompose, and is not flammable. Oxygen use therefore carries a risk that should never be overlooked, because oxygen is a strong oxidizer that vigorously supports combustion. Safety is of primary concern in oxygen service. To promote safety in oxygen systems, the flammability of materials used in them should be analyzed. At the NASA White Sands Test Facility (WSTF), we have performed configurational tests of components specifically engineered for oxygen service. These tests follow a detailed WSTF oxygen hazards analysis. The stated objective of the tests was to provide performance test data for customer use as part of a qualification plan for a particular component in a particular configuration, and under worst-case conditions. In this document - the 'Guide for Oxygen Component Qualification Tests' - we outline recommended test systems, and cleaning, handling, and test procedures that address worst-case conditions. It should be noted that test results apply specifically to: manual valves, remotely operated valves, check valves, relief valves, filters, regulators, flexible hoses, and intensifiers. Component systems are not covered.

NASA Manufacturing and Test Requirements for Normally Closed Pyrovalves for Hazardous Flight Systems Applications

NASA Technical Reports Server (NTRS)

McDougle, Stephen H.

2015-01-01

Pyrovalves (figure 1, Basic Pyrovalve Design and Features,) are typically lighter, more reliable, and in most cases less expensive than other types of valves. They also consume less electrical power. They are single-use devices that are used in propulsion systems to isolate propellants or pressurant gases. These fluids may be hazardous because of their toxicity, reactivity, temperature, or high pressure. Note that in the simplified block diagram below not all detail features are shown so that those of major interest are more prominent. The diagram is provided to point out the various features that are discussed in this Specification. Features of some NC parent metal valve designs may differ. In 2013, the NESC concluded an extensive study of the reliability and safety of NC parent metal valves used in payloads carried aboard ELVs. The assessment successfully evaluated technical data to determine the risk of NC parent metal valve leakage or inadvertent activation in ELV payloads. The study resulted in numerous recommendations to ensure personnel and hardware/facility safety during ground processing of ELV payloads. One of those recommendations was to establish a NASA specification for NC parent metal valves. This Specification is a result of that recommendation, which is documented in NESC-RP-10-00614.

Line-scan spatially offset Raman spectroscopy for inspecting subsurface food safety and quality

NASA Astrophysics Data System (ADS)

Qin, Jianwei; Chao, Kuanglin; Kim, Moon S.

2016-05-01

This paper presented a method for subsurface food inspection using a newly developed line-scan spatially offset Raman spectroscopy (SORS) technique. A 785 nm laser was used as a Raman excitation source. The line-shape SORS data was collected in a wavenumber range of 0-2815 cm-1 using a detection module consisting of an imaging spectrograph and a CCD camera. A layered sample, which was created by placing a plastic sheet cut from the original container on top of cane sugar, was used to test the capability for subsurface food inspection. A whole set of SORS data was acquired in an offset range of 0-36 mm (two sides of the laser) with a spatial interval of 0.07 mm. Raman spectrum from the cane sugar under the plastic sheet was resolved using self-modeling mixture analysis algorithms, demonstrating the potential of the technique for authenticating foods and ingredients through packaging. The line-scan SORS measurement technique provides a new method for subsurface inspection of food safety and quality.

Clinical Implication of Transaortic Mitral Pannus Removal During Repeat Cardiac Surgery for Patients With Mechanical Mitral Valve.

PubMed

Park, Byungjoon; Sung, Kiick; Park, Pyo Won

2018-01-25

This study aimed to evaluate the safety and feasibility of transaortic mitral pannus removal (TMPR).Methods and Results:Between 2004 and 2016, 34 patients (median age, 57 years; 30 women) with rheumatic disease underwent pannus removal on the ventricular side of a mechanical mitral valve through the aortic valve during reoperation. The median time interval from the previous surgery was 14 years. TMPR was performed after removal of the mechanical aortic valve (n=21) or diseased native aortic valve (n=11). TMPR was performed in 2 patients through a normal aortic valve. The mitral transprosthetic mean pressure gradient (TMPG) was ≥5 mmHg in 11 patients, including 3 with prosthetic valve malfunction. Prophylactic TMPR was performed in 23 patients. There were no early deaths. Concomitant operations included 22 tricuspid valve surgeries (13 replacements, 15 repairs) and 32 aortic valve replacements (24 repeats, 8 primary). The mean gradient in patients who had mitral TMPG ≥5 mmHg was significantly decreased from 6.46±1.1 to 4.37±1.17 mmHg at discharge (P<0.001). No mechanical valve malfunction was apparent on last echocardiography. TMPR is a safe and effective procedure for patients with malfunction or stenosis of a mechanical mitral valve and may be considered an alternative approach in patients with pannus overgrowth in such valves.

One-year outcomes after rapid-deployment aortic valve replacement.

PubMed

Young, Christopher; Laufer, Günther; Kocher, Alfred; Solinas, Marco; Alamanni, Francesco; Polvani, Gianluca; Podesser, Bruno K; Aramendi, Jose Ignacio; Arribas, Jose; Bouchot, Olivier; Livi, Ugolino; Massetti, Massimo; Terp, Kim; Giot, Christophe; Glauber, Mattia

2018-02-01

The goals of rapid-deployment aortic valve replacement include facilitation of minimally invasive surgery and reduced aortic crossclamp time. We report the short-term outcomes of a series of 493 patients undergoing rapid-deployment aortic valve replacement with the EDWARDS INTUITY valve system (Edwards Lifesciences, LLC, Irvine, Calif). Assessing Standard oF Care and Clinical Outcomes UsiNg the EDWARDS INTUITY VAlve SysTem in a European multI-center, Active, pOst-market surveillaNce Study was a prospective, multicenter (n = 26) European registry designed to evaluate the safety and performance of the valve system. During rapid-deployment aortic valve replacement, device technical success and crossclamp time were assessed. Procedural outcomes, hemodynamic performance, and various adverse events and clinical outcomes were evaluated up to 2 years. Between 2012 and 2014, 493 of 517 enrolled patients successfully received implants with the study valve (95.4% technical success). Mean crossclamp times for 163 full sternotomies, 128 mini-upper sternotomies, and 36 right anterior thoracotomies isolated aortic valve replacements were 47.3, 52.0, and 73.3 minutes, respectively. Mean follow-up was 1.8 years, with 870 total patient-years of follow-up. Mean effective orifice area increased from 0.72 (baseline) to 1.88 cm 2 , and mean pressure gradient decreased from 47.6 to 9.6 mm Hg (1 year). Mean effective orifice area index increased (0.39-1.01 cm 2 /m 2 ), and 28 of 287 patients (9.8%) exhibited severe prosthesis-patient mismatch at 1 year. After 1 year, 68.1% and 21.7% of patients were in New York Heart Association class I and II, respectively. Freedom from death, major bleeding, major perivalvular leak, reoperation, and device explant at 1 year were 0.935, 0.939, 0.976, 0.975, and 0.983, respectively. These results demonstrate commendable safety and performance of the test valve system over the short term in a broad European setting. Copyright © 2017 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

Mitral valve surgery using right anterolateral thoracotomy: is the aortic cannulation a safety procedure?

PubMed

Guedes, Marco Antonio Vieira; Pomerantzeff, Pablo Maria Alberto; Brandão, Carlos Manuel de Almeida; Vieira, Marcelo Luiz Campos; Grinberg, Max; Stolf, Noedir Antonio Groppo

2010-01-01

The right anterolateral thoracotomy is an alternative technique for surgical approach of mitral valve. In these cases, femoral-femoral bypass still has been used, rising occurrence of complications related to femoral cannulation. Describe the technique and results of mitral valve treatment by right anterolateral thoracotomy using aortic cannulation for cardiac pulmonary bypass (CPB). From 1983 e 2008, 100 consecutive female patients, with average age 35 ±13 years, 96 (96%) underwent mitral valve surgical treatment in the Heart Institute of São Paulo. A right anterolateral thoracotomy approach associated with aortic cannulation was used for CPB. Eighty (80%) patients had rheumatic disease and 84 (84%) patients presented functional class III or IV. Were performed 45 (45%) comissurotomies, 38 (38%) valve repairs, 7(7%) mitral valve replacements, seven (7%) recomissurotomies and three (3%) prosthesis replacement. Sparing surgery was performed in 90 (90%) patients. The average CPB and clamp time were 57 ± 27 min e 39 ± 19 min, respectively. There were no in-hospital death, reoperation due to bleeding and convertion to sternotomy. Introperative complications were related to heart harvest (5%), especially in reoperations (3%). The most important complications in postoperative period were related to pulmonary system (11%), followed by atrial fibrilation (10%) but without major systemic repercussions. The mean inhospital length of stay was 8 ± 3 days. Follow-up was 6.038 patients/month. Actuarial survival was 98.0 ± 1.9% and freedom from reoperation was 81.4 ± 7.8% in 180 months. The right anterolateral thoracotomy associated with aortic cannulation in mitral valve surgery is a simple technique, reproducible and safety.

National Dam Safety Program, Mill Pond Dam (Inventory Number NY 368), Lake Champlain Basin, Essex County, New York. Phase I Inspection Report

DTIC Science & Technology

1980-08-28

displaced timbers on the downstream face, replace broken timbers, repair of the valve on the drain, and repair of the spalling concrete on the wingwall which...repair of the valve on the drain, and repair of the spalling concrete on the wingwall which extends downstream of the north abutment. In addition, a...long. The gatehouse at the northern end of the dam contains the control mechanism for a valve which regulates flow at the reservoir drain inlet, an 84

Coordination of stem and leaf hydraulic conductance in southern California shrubs: a test of the hydraulic segmentation hypothesis.

PubMed

Pivovaroff, Alexandria L; Sack, Lawren; Santiago, Louis S

2014-08-01

Coordination of water movement among plant organs is important for understanding plant water use strategies. The hydraulic segmentation hypothesis (HSH) proposes that hydraulic conductance in shorter lived, 'expendable' organs such as leaves and longer lived, more 'expensive' organs such as stems may be decoupled, with resistance in leaves acting as a bottleneck or 'safety valve'. We tested the HSH in woody species from a Mediterranean-type ecosystem by measuring leaf hydraulic conductance (Kleaf) and stem hydraulic conductivity (KS). We also investigated whether leaves function as safety valves by relating Kleaf and the hydraulic safety margin (stem water potential minus the water potential at which 50% of conductivity is lost (Ψstem-Ψ50)). We also examined related plant traits including the operating range of water potentials, wood density, leaf mass per area, and leaf area to sapwood area ratio to provide insight into whole-plant water use strategies. For hydrated shoots, Kleaf was negatively correlated with KS , supporting the HSH. Additionally, Kleaf was positively correlated with the hydraulic safety margin and negatively correlated with the leaf area to sapwood area ratio. Consistent with the HSH, our data indicate that leaves may act as control valves for species with high KS , or a low safety margin. This critical role of leaves appears to contribute importantly to plant ecological specialization in a drought-prone environment. © 2014 The Authors. New Phytologist © 2014 New Phytologist Trust.

78 FR 67206 - Qualification Tests for Safety-Related Actuators in Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

... NUCLEAR REGULATORY COMMISSION [NRC-2013-0079] Qualification Tests for Safety-Related Actuators in..., ``Qualification Tests for Safety-Related Actuators in Nuclear Power Plants.'' This RG is being revised to provide... power plants. This RG is proposed Revision 1 of RG 1.73, ``Qualification Tests of Electric Valve...

75 FR 55633 - Petition for Waiver of Compliance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-13

.... 229.49(a)(1), which states that main reservoir system of each locomotives shall have a safety valve to... 4650-4679, and KCSM 4710-4759. KCS seeks authority to continue to operate with the main reservoir... adverse effects on the safety of operations and that safety is in no way compromised. Interested parties...

Treatment of Symptomatic Severe Aortic Stenosis With a Novel Resheathable Supra-Annular Self-Expanding Transcatheter Aortic Valve System.

PubMed

Manoharan, Ganesh; Walton, Antony S; Brecker, Stephen J; Pasupati, Sanjeevan; Blackman, Daniel J; Qiao, Hongyan; Meredith, Ian T

2015-08-24

The purpose of this study was to prospectively evaluate the safety and clinical performance of the CoreValve Evolut R transcatheter aortic valve replacement (TAVR) system (Medtronic, Inc., Minneapolis, Minnesota) in a single-arm, multicenter pivotal study in high- or extreme-risk patients with symptomatic aortic valve stenosis. Although outcomes following TAVR are improving, challenges still exist. The repositionable 14-F equivalent CoreValve Evolut R TAVR system was developed to mitigate some of these challenges. Suitable patients (n = 60) underwent TAVR with a 26- or 29-mm Evolut R valve. Primary safety endpoints were mortality and stroke at 30 days. Primary clinical performance endpoints were device success per the VARC-2 (Valve Academic Research Consortium-2) and the percent of patients with mild or less aortic regurgitation 24 h to 7 days post-procedure. Patients (66.7% female; mean age 82.8 ± 6.1 years; Society of Thoracic Surgeons Score 7.0 ± 3.7%) underwent TAVR via the transfemoral route in 98.3%, using a 29-mm valve in 68.3% of patients. All attempts at repositioning were successful. No death or stroke was observed up to 30 days. The VARC-2 overall device success rate was 78.6%. Paravalvular regurgitation post TAVR was mild or less in 96.6%, moderate in 3.4%, and severe in 0% at 30 days. Major vascular complications occurred in 8.3%, and permanent pacemaker implantation was required in 11.7% of patients. The repositionable 14-F equivalent Evolut R TAVR system is safe and effective at treating high-risk symptomatic aortic stenosis patients. Repositioning was successful when required in all patients, with low rates of moderate or severe paravalvular aortic regurgitation and low permanent pacemaker implantation. (The Medtronic CoreValve™ Evolut R™ CE Mark Clinical Study; NCT01876420). Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Early outcomes of percutaneous pulmonary valve implantation using the Edwards SAPIEN XT transcatheter heart valve system.

PubMed

Haas, Nikolaus A; Carere, Ronald Giacomo; Kretschmar, Oliver; Horlick, Eric; Rodés-Cabau, Josep; de Wolf, Daniël; Gewillig, Marc; Mullen, Michael; Lehner, Anja; Deutsch, Cornelia; Bramlage, Peter; Ewert, Peter

2018-01-01

Patients with congenital or acquired heart defects affecting the pulmonary valve and right ventricular outflow tract (RVOT) commonly require multiple surgical interventions, resulting in significant morbidity. A less invasive alternative is percutaneous pulmonary valve implantation (PPVI). Though studies have previously reported the safety and efficacy of the early generation transcatheter heart valves (THVs), data on more recent devices are severely lacking. We performed a multinational, multicentre, retrospective, observational registry analysis of patients who underwent PPVI using the Edwards SAPIEN XT THV. Of the 46 patients that were enrolled, the majority had tetralogy of Fallot as the underlying diagnosis (58.7%), and stentless xenograft as the most common RVOT anatomy (34.8%). Procedural success rate was high (93.5%), with a low frequency of periprocedural complications and adverse events (6.5% and 10.9%, respectively). At 30days post-procedure, NYHA class had improved significantly (90.6% were at NYHA I or II). The rate of moderate/severe pulmonary regurgitation had decreased from 76.1% at baseline to 5.0% at 30days, and the calculated peak systolic gradient had decreased from 45.2 (SD±21.3) mmHg to 16.4 (SD±8.0) mmHg, with these values remaining low up to 2years. The data suggest the efficacy and safety of the SAPIEN XT THV in PPVI in common anatomies in patients with conduits, as well as those with native pulmonary valves or transannular patches. Continued data collection is necessary to verify long-term findings. CLINICALTRIALS. NCT02302131. Copyright © 2017 Elsevier B.V. All rights reserved.

AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT XXIV, MICHIGAN/CLARK TRANSMISSION--OIL FLOW THROUGH THE CONTROL COVER ASSEMBLY.

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE SERVICING PROCEDURES FOR THE CONTROL SYSTEM OF A SPECIFIC TRANSMISSION USED ON DIESEL POWERED EQUIPMENT. TOPICS ARE EXAMINING THE CONTROL COVER ASSEMBLY, REGULATING VALVE AND SAFETY VALVE, AND INSPECTING THE SYSTEM. THE MODULE CONSISTS OF A SELF-INSTRUCTIONAL…

77 FR 59673 - Petitions for Modification of Application of Existing Mandatory Safety Standards

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-28

... will examine valves and nozzles for damage malfunction and close the door fully before opening the air... failure pressure of 1,300 pounds per square inch, capped at the base, and actuated by an electrically controlled ball valve at the top. 6. Air nozzles must not exceed 30 pounds per square inch gauge. 7. The...

Will Catheter Interventions Replace Surgery for Valve Abnormalities?

PubMed Central

O’Byrne, Michael L; Gillespie, Matthew J

2015-01-01

Purpose of Review Catheter-based valve technologies have evolved rapidly over the last decade. Transcatheter aortic valve replacement (TAVR) has become a routine procedure in high-risk adult patients with calcific aortic stenosis. In patients with congenital heart disease (CHD), transcatheter pulmonary valve replacement represents a transformative technology for right ventricular outflow tract dysfunction with the potential to expand to other indications. This review aims to summarize 1) the current state of the art for transcatheter valve replacement (TVR) in CHD, 2) the expanding indications for TVR, and 3) the technological obstacles to optimizing TVR. Recent findings Multiple case series have demonstrated that TVR with the Melody transcatheter pulmonary valve in properly selected patients is safe, effective, and durable in short-term follow-up. The Sapien transcatheter heart valve represents an alternative device with similar safety and efficacy in limited studies. Innovative use of current valves has demonstrated the flexibility of TVR, while highlighting the need for devices to address the broad range of post-operative anatomies either with a single device or strategies to prepare the outflow tract for subsequent device deployment. Summary The potential of TVR has not been fully realized, but holds promise in treatment of CHD. PMID:24281347

Transcatheter Pulmonary Valve Replacement by Hybrid Approach Using a Novel Polymeric Prosthetic Heart Valve: Proof of Concept in Sheep

PubMed Central

Xu, Tong-yi; Zhang, Zhi-gang; Li, Xin; Han, Lin; Xu, Zhi-yun

2014-01-01

Background Since 2000, transcatheter pulmonary valve replacement has steadily advanced. However, the available prosthetic valves are restricted to bioprosthesis which have defects like poor durability. Polymeric heart valve is thought as a promising alternative to bioprosthesis. In this study, we introduced a novel polymeric transcatheter pulmonary valve and evaluated its feasibility and safety in sheep by a hybrid approach. Methods We designed a novel polymeric trileaflet transcatheter pulmonary valve with a balloon-expandable stent, and the valve leaflets were made of 0.1-mm expanded polytetrafluoroethylene (ePTFE) coated with phosphorylcholine. We chose glutaraldehyde-treated bovine pericardium valves as control. Pulmonary valve stents were implanted in situ by a hybrid transapical approach in 10 healthy sheep (8 for polymeric valve and 2 for bovine pericardium valve), weighing an average of 22.5±2.0 kg. Angiography and cardiac catheter examination were performed after implantation to assess immediate valvular functionality. After 4-week follow-up, angiography, echocardiography, computed tomography, and cardiac catheter examination were used to assess early valvular function. One randomly selected sheep with polymeric valve was euthanized and the explanted valved stent was analyzed macroscopically and microscopically. Findings Implantation was successful in 9 sheep. Angiography at implantation showed all 9 prosthetic valves demonstrated orthotopic position and normal functionality. All 9 sheep survived at 4-week follow-up. Four-week follow-up revealed no evidence of valve stent dislocation or deformation and normal valvular and cardiac functionality. The cardiac catheter examination showed the peak-peak transvalvular pressure gradient of the polymeric valves was 11.9±5.0 mmHg, while that of two bovine pericardium valves were 11 and 17 mmHg. Gross morphology demonstrated good opening and closure characteristics. No thrombus or calcification was seen macroscopically. Conclusions This design of the novel ePTFE transcatheter pulmonary valve is safe and effective to deploy in sheep by hybrid approach, and the early valvular functionality is good. PMID:24926892

Emerging Transcatheter Options for Tricuspid Regurgitation

PubMed Central

Kalra, Ankur; Uberoi, Angad S.; Latib, Azeem; Khera, Sahil; Little, Stephen H.; Bhatt, Deepak L.; Reardon, Michael J.; Kleiman, Neal S.; Barker, Colin M.

2017-01-01

Tricuspid regurgitation (TR) presents as either primary valve pathology or secondary to pulmonary or left-sided heart disease. Severe TR portends a worse prognosis independent of age, right ventricular size and function, severe left ventricular dysfunction, and increased pulmonary arterial pressures. Surgical treatment for TR has mostly been limited to patients undergoing mitral valve repair since those at high surgical risk are not candidates for traditional TR surgery. For these patients, minimally invasive techniques could be of great benefit, yet these techniques have been slow to develop because of the various anatomic and physiological aspects of the tricuspid valve apparatus. Several promising new techniques are currently undergoing clinical investigation, including caval valve implantation, percutaneous tricuspid annuloplasty techniques (Trialign, TriCinch, Cardioband), edge-to-edge repair with the MitraClip system, the FORMA device, and the GATE tricuspid Atrioventricular Valved Stent. Further evaluation of their safety and long-term efficacy is warranted prior to commercial approval and widespread adoption. PMID:29743996

46 CFR 50.01-15 - Scope of regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... choice of materials for machinery, boilers, pressure vessels, safety valves, and piping systems upon which safety of life is dependent. (b) Since this subchapter contains the marine engineering details, it... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING GENERAL PROVISIONS Basis and...

46 CFR 50.01-15 - Scope of regulations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... choice of materials for machinery, boilers, pressure vessels, safety valves, and piping systems upon which safety of life is dependent. (b) Since this subchapter contains the marine engineering details, it... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING GENERAL PROVISIONS Basis and...

46 CFR 50.01-15 - Scope of regulations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... choice of materials for machinery, boilers, pressure vessels, safety valves, and piping systems upon which safety of life is dependent. (b) Since this subchapter contains the marine engineering details, it... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING GENERAL PROVISIONS Basis and...

46 CFR 50.01-15 - Scope of regulations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... choice of materials for machinery, boilers, pressure vessels, safety valves, and piping systems upon which safety of life is dependent. (b) Since this subchapter contains the marine engineering details, it... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING GENERAL PROVISIONS Basis and...

46 CFR 50.01-15 - Scope of regulations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... choice of materials for machinery, boilers, pressure vessels, safety valves, and piping systems upon which safety of life is dependent. (b) Since this subchapter contains the marine engineering details, it... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING GENERAL PROVISIONS Basis and...

THE EFFECTS OF MAINTENANCE ACTIONS ON THE PFDavg OF SPRING OPERATED PRESSURE RELIEF VALVES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, S.; Gross, R.

2014-04-01

The safety integrity level (SIL) of equipment used in safety instrumented functions is determined by the average probability of failure on demand (PFDavg) computed at the time of periodic inspection and maintenance, i.e., the time of proof testing. The computation of PFDavg is generally based solely on predictions or estimates of the assumed constant failure rate of the equipment. However, PFDavg is also affected by maintenance actions (or lack thereof) taken by the end user. This paper shows how maintenance actions can affect the PFDavg of spring operated pressure relief valves (SOPRV) and how these maintenance actions may be accountedmore » for in the computation of the PFDavg metric. The method provides a means for quantifying the effects of changes in maintenance practices and shows how these changes impact plant safety.« less

The Effects of Maintenance Actions on the PFDavg of Spring Operated Pressure Relief Valves

DOE PAGES

Harris, S.; Gross, R.; Goble, W; ...

2015-12-01

The safety integrity level (SIL) of equipment used in safety instrumented functions is determined by the average probability of failure on demand (PFDavg) computed at the time of periodic inspection and maintenance, i.e., the time of proof testing. The computation of PFDavg is generally based solely on predictions or estimates of the assumed constant failure rate of the equipment. However, PFDavg is also affected by maintenance actions (or lack thereof) taken by the end user. This paper shows how maintenance actions can affect the PFDavg of spring operated pressure relief valves (SOPRV) and how these maintenance actions may be accountedmore » for in the computation of the PFDavg metric. The method provides a means for quantifying the effects of changes in maintenance practices and shows how these changes impact plant safety.« less

Safety Analysis LOX-30 Liquid Oxygen Generator.

DTIC Science & Technology

1978-05-22

Valve. Protects the LOX—30 plant against over—pressurization. Valve opens at approximately 100 psig. (3) Oil Pressure Switch . Protects compressor...29 psig. d. Cryogenerator. •0 (1) 011 Pressure Switch . Prevents cryogenerator damage due to inadequate lubrication. The switch initiates system shut...when helium pressure is less than 200 psig, will result in compressor shut—down within ten seconds. (2) Differential Pressure Switch (2 each). These

Interventional Treatment of Severe Tricuspid Regurgitation: Early Clinical Experience in a Multicenter, Observational, First-in-Man Study.

PubMed

Lauten, Alexander; Figulla, Hans R; Unbehaun, Axel; Fam, Neil; Schofer, Joachim; Doenst, Torsten; Hausleiter, Joerg; Franz, Marcus; Jung, Christian; Dreger, Henryk; Leistner, David; Alushi, Brunilda; Stundl, Anja; Landmesser, Ulf; Falk, Volkmar; Stangl, Karl; Laule, Michael

2018-02-01

Transcatheter caval valve implantation is under evaluation as a treatment option for inoperable patients with severe tricuspid regurgitation (TR). The procedure involves the catheter-based implantation of bioprosthetic valves in the inferior vena cava and superior vena cava to treat symptoms associated with TR. This study is the first to evaluate the feasibility, safety, and efficacy of this interventional concept. Twenty-five patients (mean age, 73.9±7.6 years; women, 52.0%) with severe symptomatic TR despite optimal medical treatment deemed unsuitable for surgery were treated with caval valve implantation under a compassionate clinical use program. Technical feasibility defined as procedural success, hemodynamic effect defined as venous pressure reduction, and safety defined as periprocedural adverse events were evaluated, with clinical follow-up at discharge and up to 12 months. The functional impact was evaluated by assessment of New York Heart Association class at the time of hospital discharge. The total number of valves implanted in the caval position was 31. Patients were treated with single (inferior vena cava-only; n=19; 76.0%) or bicaval valve implantation (inferior vena cava+superior vena cava; n=6; 24.0%). Either balloon-expandable valves (Sapien XT/3: n=18; 72.0%) or self-expandable valves (TricValve: n=6; 24.0%; Directflow: n=1; 4.0%) were used. Procedural success was achieved in 96% (n=24). Early and late valve migration requiring surgical intervention occurred in 1 patient each. Thirty-day and in-hospital mortality were 8% (2 of 25) and 16% (4 of 25). Causes of in-hospital mortality included respiratory (n=1) or multiple organ failure (n=3) and were not linked to the procedure. Mean overall survival in the study cohort was 316±453 days (14-1540 days). Caval valve implantation for the treatment of severe TR and advanced right ventricular failure is associated with a high procedural success rate and seems safe and feasible in an excessive-risk cohort. The study demonstrates hemodynamic efficacy with consistent elimination of TR-associated venous backflow and initial clinical improvement. These results encourage further trials to determine which patients benefit most from this interventional approach. © 2018 American Heart Association, Inc.

Line-scan spatially offset Raman spectroscopy for inspecting subsurface food safety and quality

USDA-ARS?s Scientific Manuscript database

This paper presented a method for subsurface food inspection using a newly developed line-scan spatially offset Raman spectroscopy (SORS) technique. A 785 nm laser was used as a Raman excitation source. The line-shape SORS data was collected in a wavenumber range of 0–2815 cm-1 using a detection mod...

RAMONA-3B application to Browns Ferry ATWS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slovik, G.C.; Neymotin, L.; Cazzoli, E.

1984-01-01

This paper discusses two preliminary MSIV clsoure ATWS calculations done using the RAMONA-3B code and the work being done to create the necessary cross section sets for the Browns Ferry Unit 1 reactor. The RAMONA-3B code employs a three-dimensional neutron kinetics model coupled with one-dimensional, four equation, nonhomogeneous, nonequilibrium thermal hydraulics. To be compatible with 3-D neutron kinetics, the code uses parallel coolant channels in the core. It also includes a boron transport model and all necessary BWR components such as jet pump, recirculation pump, steam separator, steamline with safety and relief valves, main steam isolation valve, turbine stop valve,more » and turbine bypass valve. A summary of RAMONA-3B neutron kinetics and thermal hydraulics models is presented in the Appendix.« less

Mid-term study of transcatheter aortic valve implantation in an Asian population with severe aortic stenosis: two-year Valve Academic Research Consortium-2 outcomes

PubMed Central

Chew, Nicholas; Hon, Jimmy Kim Fatt; Yip, Wei Luen James; Chan, Siew Pang; Poh, Kian-Keong; Kong, William Kok-Fai; Teoh, Kristine Leok Kheng; Yeo, Tiong Cheng; Tan, Huay Cheem; Tay, Edgar Lik Wui

2017-01-01

INTRODUCTION Transcatheter aortic valve implantation (TAVI) is an effective treatment for high-risk or inoperative patients with severe aortic stenosis. Given the unique characteristics of Asian populations, questions regarding mid-term outcomes in Asians undergoing TAVI have yet to be addressed. We evaluated the two-year clinical outcomes of TAVI in an Asian population using Valve Academic Research Consortium-2 definitions. METHODS This prospective study recruited 59 patients from a major academic medical centre in Singapore. The main outcomes were two-year survival rates, peri-procedural complications, symptom improvement, valvular function and assessment of learning curve. RESULTS Mean age was 76.8 years (61.0% male), mean body surface area 1.6 m2 and mean logistic EuroSCORE 18.7%. Survival was 93.2%, 86.0% and 79.1% at 30 days, one year and two years, respectively. At 30 days post TAVI, the rate of stroke was 1.7%, life-threatening bleeding 5.1%, acute kidney injury 25.0%, major vascular complication 5.1%, and new permanent pacemaker implantation 6.8%. 29.3% of TAVI patients were rehospitalised (47.1% cardiovascular-related) within one year. These composite outcomes were measured: device success (93.2%); early safety (79.7%); clinical efficacy (66.1%); and time-related valve safety (84.7%). Univariate analysis found these predictors of two-year all-cause mortality: logistic EuroSCORE (hazard ratio [HR] 1.07; p < 0.001); baseline estimated glomerular filtration rate (HR 0.97; p = 0.048); and acute kidney injury (HR 5.33; p = 0.022). Multivariate analysis identified non-transfemoral TAVI as a predictor of cardiovascular-related two-year mortality (HR 14.64; p = 0.008). CONCLUSION Despite the unique clinical differences in Asian populations, this registry demonstrated favourable mid-term clinical and safety outcomes in Asians undergoing TAVI. PMID:27516113

Mid-term study of transcatheter aortic valve implantation in an Asian population with severe aortic stenosis: two-year Valve Academic Research Consortium-2 outcomes.

PubMed

Chew, Nicholas; Hon, Jimmy Kim Fatt; Yip, Wei Luen James; Chan, Siew Pang; Poh, Kian-Keong; Kong, William Kok-Fai; Teoh, Kristine Leok Kheng; Yeo, Tiong Cheng; Tan, Huay Cheem; Tay, Edgar Lik Wui

2017-09-01

Transcatheter aortic valve implantation (TAVI) is an effective treatment for high-risk or inoperative patients with severe aortic stenosis. Given the unique characteristics of Asian populations, questions regarding mid-term outcomes in Asians undergoing TAVI have yet to be addressed. We evaluated the two-year clinical outcomes of TAVI in an Asian population using Valve Academic Research Consortium-2 definitions. This prospective study recruited 59 patients from a major academic medical centre in Singapore. The main outcomes were two-year survival rates, peri-procedural complications, symptom improvement, valvular function and assessment of learning curve. Mean age was 76.8 years (61.0% male), mean body surface area 1.6 m 2 and mean logistic EuroSCORE 18.7%. Survival was 93.2%, 86.0% and 79.1% at 30 days, one year and two years, respectively. At 30 days post TAVI, the rate of stroke was 1.7%, life-threatening bleeding 5.1%, acute kidney injury 25.0%, major vascular complication 5.1%, and new permanent pacemaker implantation 6.8%. 29.3% of TAVI patients were rehospitalised (47.1% cardiovascular-related) within one year. These composite outcomes were measured: device success (93.2%); early safety (79.7%); clinical efficacy (66.1%); and time-related valve safety (84.7%). Univariate analysis found these predictors of two-year all-cause mortality: logistic EuroSCORE (hazard ratio [HR] 1.07; p < 0.001); baseline estimated glomerular filtration rate (HR 0.97; p = 0.048); and acute kidney injury (HR 5.33; p = 0.022). Multivariate analysis identified non-transfemoral TAVI as a predictor of cardiovascular-related two-year mortality (HR 14.64; p = 0.008). Despite the unique clinical differences in Asian populations, this registry demonstrated favourable mid-term clinical and safety outcomes in Asians undergoing TAVI. Copyright: © Singapore Medical Association

Thrombolytic therapy for mitral valve thrombosis.

PubMed

Lin, T K; Tsai, L M; Chen, J H; Yang, Y J

1997-05-01

A 44-year-old man with a St. Jude mitral valve was admitted because of progressive pulmonary edema. He was diagnosed with prosthetic heart valve thrombosis (PHVT) based on the findings of "muffled" prosthetic valve clicks. Doppler echocardiographic evidence of severe mitral stenosis and transesophageal echocardiographic evidence of limited mitral valve motility. Because the patient hesitated to undergo our recommended surgical treatment, he was immediately treated with intravenous recombinant tissue plasminogen activator (100 mg over 3 h) followed by heparinization. Two hours after the thrombolytic therapy, the prosthetic valve clicks became clearly audible and his congestive symptoms were dramatically improved. Follow-up echocardiography no longer-showed significant mitral valve obstruction. A transient cerebral ischemic attack occurred at the end of thrombolytic therapy but there were no neurologic sequalae. The patient, on warfarin therapy, was well at follow-up 8 months after discharge. Surgical intervention has long been the standard therapy for patients with PHVT. Our case experience suggests that thrombolytic therapy may be considered as an effective alternative to surgical intervention for selected patients with PHVT. In this report, we also review the current literature regarding the indications, effectiveness and safety of thrombolytic therapy in PHVT.

Structural safety analysis based on seismic service conditions for butterfly valves in a nuclear power plant.

PubMed

Han, Sang-Uk; Ahn, Dae-Gyun; Lee, Myeong-Gon; Lee, Kwon-Hee; Han, Seung-Ho

2014-01-01

The structural integrity of valves that are used to control cooling waters in the primary coolant loop that prevents boiling within the reactor in a nuclear power plant must be capable of withstanding earthquakes or other dangerous situations. In this study, numerical analyses using a finite element method, that is, static and dynamic analyses according to the rigid or flexible characteristics of the dynamic properties of a 200A butterfly valve, were performed according to the KEPIC MFA. An experimental vibration test was also carried out in order to verify the results from the modal analysis, in which a validated finite element model was obtained via a model-updating method that considers changes in the in situ experimental data. By using a validated finite element model, the equivalent static load under SSE conditions stipulated by the KEPIC MFA gave a stress of 135 MPa that occurred at the connections of the stem and body. A larger stress of 183 MPa was induced when we used a CQC method with a design response spectrum that uses 2% damping ratio. These values were lower than the allowable strength of the materials used for manufacturing the butterfly valve, and, therefore, its structural safety met the KEPIC MFA requirements.

Conceptual design of ACB-CP for ITER cryogenic system

NASA Astrophysics Data System (ADS)

Jiang, Yongcheng; Xiong, Lianyou; Peng, Nan; Tang, Jiancheng; Liu, Liqiang; Zhang, Liang

2012-06-01

ACB-CP (Auxiliary Cold Box for Cryopumps) is used to supply the cryopumps system with necessary cryogen in ITER (International Thermonuclear Experimental Reactor) cryogenic distribution system. The conceptual design of ACB-CP contains thermo-hydraulic analysis, 3D structure design and strength checking. Through the thermohydraulic analysis, the main specifications of process valves, pressure safety valves, pipes, heat exchangers can be decided. During the 3D structure design process, vacuum requirement, adiabatic requirement, assembly constraints and maintenance requirement have been considered to arrange the pipes, valves and other components. The strength checking has been performed to crosscheck if the 3D design meets the strength requirements for the ACB-CP.

30 CFR 250.1004 - Safety equipment requirements for DOI pipelines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Pipelines and Pipeline Rights-of... a flow safety valve (FSV). (ii) For sulphur operations, incoming pipelines delivering gas to the power plant platform may be equipped with high- and low-pressure sensors (PSHL), which activate audible...

30 CFR 250.1625 - Blowout preventer system testing, records, and drills.

Code of Federal Regulations, 2014 CFR

2014-07-01

... drills. 250.1625 Section 250.1625 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT... Operations § 250.1625 Blowout preventer system testing, records, and drills. (a) Prior to conducting high..., upper and lower kelly cocks, and drill-string safety valves shall be pressure tested to pipe-ram test...

30 CFR 250.1625 - Blowout preventer system testing, records, and drills.

Code of Federal Regulations, 2012 CFR

2012-07-01

... drills. 250.1625 Section 250.1625 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT... Operations § 250.1625 Blowout preventer system testing, records, and drills. (a) Prior to conducting high..., upper and lower kelly cocks, and drill-string safety valves shall be pressure tested to pipe-ram test...

30 CFR 250.1625 - Blowout preventer system testing, records, and drills.

Code of Federal Regulations, 2013 CFR

2013-07-01

... drills. 250.1625 Section 250.1625 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT... Operations § 250.1625 Blowout preventer system testing, records, and drills. (a) Prior to conducting high..., upper and lower kelly cocks, and drill-string safety valves shall be pressure tested to pipe-ram test...

Preoperative planning with three-dimensional reconstruction of patient's anatomy, rapid prototyping and simulation for endoscopic mitral valve repair.

PubMed

Sardari Nia, Peyman; Heuts, Samuel; Daemen, Jean; Luyten, Peter; Vainer, Jindrich; Hoorntje, Jan; Cheriex, Emile; Maessen, Jos

2017-02-01

Mitral valve repair performed by an experienced surgeon is superior to mitral valve replacement for degenerative mitral valve disease; however, many surgeons are still deterred from adapting this procedure because of a steep learning curve. Simulation-based training and planning could improve the surgical performance and reduce the learning curve. The aim of this study was to develop a patient-specific simulation for mitral valve repair and provide a proof of concept of personalized medicine in a patient prospectively planned for mitral valve surgery. A 65-year old male with severe symptomatic mitral valve regurgitation was referred to our mitral valve heart team. On the basis of three-dimensional (3D) transoesophageal echocardiography and computed tomography, 3D reconstructions of the patient's anatomy were constructed. By navigating through these reconstructions, the repair options and surgical access were chosen (minimally invasive repair). Using rapid prototyping and negative mould fabrication, we developed a process to cast a patient-specific mitral valve silicone replica for preoperative repair in a high-fidelity simulator. Mitral valve and negative mould were printed in systole to capture the pathology when the valve closes. A patient-specific mitral valve silicone replica was casted and mounted in the simulator. All repair techniques could be performed in the simulator to choose the best repair strategy. As the valve was printed in systole, no special testing other than adjusting the coaptation area was required. Subsequently, the patient was operated, mitral valve pathology was validated and repair was successfully done as in the simulation. The patient-specific simulation and planning could be applied for surgical training, starting the (minimally invasive) mitral valve repair programme, planning of complex cases and the evaluation of new interventional techniques. The personalized medicine could be a possible pathway towards enhancing reproducibility, patient's safety and effectiveness of a complex surgical procedure. © The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Transapical implantation of a second-generation transcatheter heart valve in patients with noncalcified aortic regurgitation.

PubMed

Seiffert, Moritz; Diemert, Patrick; Koschyk, Dietmar; Schirmer, Johannes; Conradi, Lenard; Schnabel, Renate; Blankenberg, Stefan; Reichenspurner, Hermann; Baldus, Stephan; Treede, Hendrik

2013-06-01

This study sought to report on the feasibility and early results of transcatheter aortic valve implantation employing a second-generation device in a series of patients with pure aortic regurgitation. Efficacy and safety of transcatheter aortic valve implantation in patients with calcific aortic stenosis and high surgical risk has been demonstrated. However, experience with implantation for severe noncalcified aortic regurgitation has been limited due to increased risk for valve dislocation or annular rupture. Five patients (mean age: 66.6 ± 7 years) underwent transapical implantation of a JenaValve (JenaValve Technology GmbH, Munich, Germany) transcatheter heart valve for moderate to severe, noncalcified aortic regurgitation. All patients were considered high risk for surgical aortic valve replacement after evaluation by an interdisciplinary heart team (logistic EuroSCORE [European System for Cardiac Operative Risk Evaluation] range 3.1% to 38.9%). Procedural and acute clinical outcomes were analyzed. Implantation was successful in all cases without relevant remaining aortic regurgitation or signs of stenosis in any of the patients. No major device- or procedure-related adverse events occurred and all 5 patients were alive with improved exercise tolerance at 3-month follow-up. Noncalcified aortic regurgitation continues to be a challenging pathology for transcatheter aortic valve implantation due to the risk for insufficient anchoring of the valve stent within the aortic annulus. This report provides first evidence that the JenaValve prosthesis may be a reasonable option in these specific patients due to its unique stent design, clipping the native aortic valve leaflets, and offering promising early results. Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Evaluation of the marker of hypercoagulability prothrombin fragment F 1+2 in patients with mechanical or biological heart valve prostheses.

PubMed

Ferreira, Claudia Natália; Vieira, Lauro Mello; Dusse, Luci Maria Sant'Ana; Amaral, Carlos Faria Santos; de Magalhães Esteves, William Antônio; Fenelon, Lúcia Maria Amorim; das Graças Carvalho, Maria

2002-11-01

To investigate whether patients with heart valve prostheses and similar International Normalized Ratios (INR) have the same level of protection against thromboembolic events, that is, whether the anticoagulation intensity is related to the intensity of hypercoagulability suppression. INR and plasma levels of prothrombin fragment 1+2 (F1+2) were assessed in blood samples of 27 patients (7 with mechanical heart valves and 20 with biological heart valves) and 27 blood samples from healthy donors that were not taking any medication. Increased levels of F1+2 were observed in blood samples of 5 patients with heart valve prostheses taking warfarin. These findings reinforce the idea that even though patients may have INRs, within the therapeutic spectrum, they are not free from new thromboembolic events. Determination of the hypercoagulability marker F1+2 might result in greater efficacy and safety for the use of oral anticoagulants, resulting in improved quality of life for patients.

[Testing system design and analysis for the execution units of anti-thrombotic device].

PubMed

Li, Zhelong; Cui, Haipo; Shang, Kun; Liao, Yuehua; Zhou, Xun

2015-02-01

In an anti-thrombotic pressure circulatory device, relays and solenoid valves serve as core execution units. Thus the therapeutic efficacy and patient safety of the device will directly depend on their performance. A new type of testing system for relays and solenoid valves used in the anti-thrombotic device has been developed, which can test action response time and fatigue performance of relay and solenoid valve. PC, data acquisition card and test platform are used in this testing system based on human-computer interaction testing modules. The testing objectives are realized by using the virtual instrument technology, the high-speed data acquisition technology and reasonable software design. The two sets of the system made by relay and solenoid valve are tested. The results proved the universality and reliability of the testing system so that these relays and solenoid valves could be accurately used in the antithrombotic pressure circulatory equipment. The newly-developed testing system has a bright future in the aspects of promotion and application prospect.

Which way in? The Necessity of Multiple Approaches to Transcatheter Valve Therapy

PubMed Central

Bleiziffer, S.; Krane, M.; Deutsch, M.A.; Elhmidi, Y.; Piazza, N.; Voss, B.; Lange, R.

2013-01-01

TAVI (transcatheter aortic valve implantation) is a less invasive treatment of the stenotic aortic valve while avoiding midline sternotomy and cardiopulmonary bypass. A crimped biological valve on a self-expanding or balloon-expandable stent is inserted antegradely or retrogradely under fluoroscopy, and deployed on the beating heart. Among the worldwide TAVI programs, many different concepts have been established for the choice of the access site. Whether retrograde or antegrade TAVI should be considered the superior approach is matter of an ongoing debate. The published literature demonstrates safety of all techniques if performed within a dedicated multidisciplinary team. Since there is no data providing evidence if one approach is superior to another, we conclude that an individualized patient-centered decision making process is most beneficial, taking advantage of the complementarity of the different access options. The aim of this article is to give an overview of the current practice of access techniques for transcatheter based valve treatment and to outline the respective special characteristics. PMID:24313647

Cardioband system as a treatment for functional mitral regurgitation.

PubMed

Ferrero Guadagnoli, Adolfo; De Carlo, Carlotta; Maisano, Francesco; Ho, Edwin; Saccocci, Matteo; Cuevas, Oscar; Luciani, Marco; Kuwata, Shingo; Nietlispach, Fabian; Taramasso, Maurizio

2018-06-07

Are the current data on the Cardioband in the clinical area enough to consider it a tool for mitral regurgitation treatment? Severe secondary mitral valve insufficiency frequently affects high-risk surgical patients. The Cardioband system is a novel percutaneous surgical-like device for direct annuloplasty. It is implanted into the beating heart by transvenous femoral access, with minimal impact on hemodynamic and cardiac function during implantation. So far, it has demonstrated safety and feasibility in high-risk patients with functional mitral regurgitation; it has imparted significant annular reduction and regurgitation improvements. In well-selected patients, it could be an option for mitral valve repair. Areas covered: This is a bibliographic review based on scientific publications and medical congress reports. It includes the most current information related to Cardioband in mitral regurgitation. Expert commentary: This novel, less-invasive and effective tool is an option for the open repair or replacement of the mitral valve in high-risk surgical patients. Although the current results of Cardioband are promising, more data and longer follow-up times are necessary to confirm its safety and efficacy and to evaluate the durability of the results.

Maladjustment of programmable ventricular shunt valves by inadvertent exposure to a common hospital device.

PubMed

Fujimura, R; Lober, R; Kamian, K; Kleiner, L

2018-01-01

Programmable ventricular shunt valves are commonly used to treat hydrocephalus. They can be adjusted to allow for varying amounts of cerebrospinal fluid (CSF) flow using an external magnetic programming device, and are susceptible to maladjustment from inadvertent exposure to magnetic fields. We describe the case of a 3-month-old girl treated for hydrocephalus with a programmable Strata TM II valve found at the incorrect setting on multiple occasions during her hospitalization despite frequent reprogramming and surveillance. We found that the Vocera badge, a common hands-free wireless communication system worn by our nursing staff, had a strong enough magnetic field to unintentionally change the shunt setting. The device is worn on the chest bringing it into close proximity to the shunt valve when care providers hold the baby, resulting in the maladjustment. Some commonly used medical devices have a magnetic field strong enough to alter programmable shunt valve settings. Here, we report that the magnetic field from the Vocera hands-free wireless communication system, combined with the worn position, results in shunt maladjustment for the Strata TM II valve. Healthcare facilities using the Vocera badges need to put protocols in place and properly educate staff members to ensure the safety of patients with Strata TM II valves.

30 CFR 250.1630 - Safety-system testing and records.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur... these components, and the following: (1) Safety relief valves on the natural gas feed system for power... level sensors) must be inspected and tested at least once each calendar month, but at no time may more...

49 CFR 179.200-22 - Test of tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... evidence of distress. All rivets and closures, except safety relief valves or safety vents, shall be in place when test is made. (b) Insulated tanks shall be tested before insulation is applied. (c) Rubber-lined tanks shall be tested before rubber lining is applied. (d) Caulking of welded joints to stop leaks...

49 CFR 179.200-22 - Test of tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... evidence of distress. All rivets and closures, except safety relief valves or safety vents, shall be in place when test is made. (b) Insulated tanks shall be tested before insulation is applied. (c) Rubber-lined tanks shall be tested before rubber lining is applied. (d) Caulking of welded joints to stop leaks...

49 CFR 179.200-22 - Test of tanks.

Code of Federal Regulations, 2014 CFR

2014-10-01

... evidence of distress. All rivets and closures, except safety relief valves or safety vents, shall be in place when test is made. (b) Insulated tanks shall be tested before insulation is applied. (c) Rubber-lined tanks shall be tested before rubber lining is applied. (d) Caulking of welded joints to stop leaks...

49 CFR 179.200-22 - Test of tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... evidence of distress. All rivets and closures, except safety relief valves or safety vents, shall be in place when test is made. (b) Insulated tanks shall be tested before insulation is applied. (c) Rubber-lined tanks shall be tested before rubber lining is applied. (d) Caulking of welded joints to stop leaks...

Transcatheter direct mitral valve annuloplasty with the Cardioband system for the treatment of functional mitral regurgitation.

PubMed

Taramasso, Maurizio; Inderbitzin, Devdas T; Guidotti, Andrea; Nietlispach, Fabian; Gaemperli, Oliver; Zuber, Michel; Maisano, Francesco

2016-01-01

Direct mitral valve annuloplasty is a transcatheter mitral valve repair approach that mimics the conventional surgical approach to treat functional mitral regurgitation. The Cardioband system (Valtech Cardio, Inc., Or-Yehuda, Israel) is delivered by a trans-septal approach and the implant is performed on the atrial side of the mitral annulus, under live echo and fluoroscopic guidance using multiple anchor elements. The Cardioband system obtained CE mark approval in October 2015, and initial clinical experiences are promising with regard to feasibility, safety and efficacy. © The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Analysis of failure and maintenance experiences of motor operated valves in a Finnish nuclear power plant

NASA Astrophysics Data System (ADS)

Simola, Kaisa; Laakso, Kari

1992-01-01

Eight years of operating experiences of 104 motor operated closing valves in different safety systems in nuclear power units were analyzed in a systematic way. The qualitative methods used were Failure Mode and Effect Analysis (FMEA) and Maintenance Effects and Criticality Analysis (MECA). These reliability engineering methods are commonly used in the design stage of equipment. The successful application of these methods for analysis and utilization of operating experiences was demonstrated.

Defining microchannels and valves on a hydrophobic paper by low-cost inkjet printing of aqueous or weak organic solutions.

PubMed

Cai, Longfei; Zhong, Minghua; Li, Huolin; Xu, Chunxiu; Yuan, Biyu

2015-07-01

We describe a simple and cost-effective strategy for rapid fabrication of microfluidic paper-based analytical devices and valves by inkjet printing. NaOH aqueous solution was printed onto a hydrophobic filter paper, which was previously obtained by soaking in a trimethoxyoctadecylsilane-heptane solution, allowing selective wet etching of hydrophobic cellulose to create hydrophilic-hydrophobic contrast with a relatively good resolution. Hexadecyltrimethylammonium bromide (CTMAB)-ethanol solution was printed onto hydrophobic paper to fabricate temperature-controlled valves. At low temperature, CTMAB deposited on the paper is insoluble in aqueous fluid, thus the paper remains hydrophobic. At high temperature, CTMAB becomes soluble so the CTMAB-deposited channel becomes hydrophilic, allowing the wicking of aqueous solution through the valve. We believe that this strategy will be very attractive for the development of simple micro analytical devices for point-of-care applications, including diagnostic testing, food safety control, and environmental monitoring.

Burner ignition system

DOEpatents

Carignan, Forest J.

1986-01-21

An electronic ignition system for a gas burner is battery operated. The battery voltage is applied through a DC-DC chopper to a step-up transformer to charge a capacitor which provides the ignition spark. The step-up transformer has a significant leakage reactance in order to limit current flow from the battery during initial charging of the capacitor. A tank circuit at the input of the transformer returns magnetizing current resulting from the leakage reactance to the primary in succeeding cycles. An SCR in the output circuit is gated through a voltage divider which senses current flow through a flame. Once the flame is sensed, further sparks are precluded. The same flame sensor enables a thermopile driven main valve actuating circuit. A safety valve in series with the main gas valve responds to a control pressure thermostatically applied through a diaphragm. The valve closes after a predetermined delay determined by a time delay orifice if the pilot gas is not ignited.

Chemical Accident Prevention Publications

EPA Pesticide Factsheets

These include chemical safety alerts, emergency preparedness and prevention advisories, and topical backgrounders. Excess flow valves, protecting workers in ethylene oxide sterilization facilities, reactivity hazards, and delayed coker units are covered.

Clinical Experience with the M4 Ahmed Glaucoma Drainage Implant.

PubMed

Sluch, Ilya; Gudgel, Brett; Dvorak, Justin; Anne Ahluwalia, Mary; Ding, Kai; Vold, Steve; Sarkisian, Steven

2017-01-01

To evaluate the safety and efficacy of the M4 (porous polyethylene plate) Ahmed Glaucoma Valve (AGV) drainage implant in a multicenter retrospective study. A retrospective chart review of medical records of patients who had undergone the M4 Ahmed valve was performed from January 2013 to April 2015. The primary outcome measure was surgical failure defined as: Less than a 20% reduction in baseline intraocular pressure (IOP) to last follow-up visit, final IOP less than 5 mm Hg or greater than 18 mm Hg, reoperation for glaucoma, or loss of light perception vision. All eyes not meeting the above criteria were defined as success. A total of 291 eyes met all study inclusion criteria. The average follow-up in the study was 6 months (±7.6 months) with 112 patients achieving 12-month follow-up (38.5%). 208 eyes (71.5%) met the study success criteria at final follow-up. No statistically significant spikes in postoperative IOP at 1 and 4 months were detected. The average preoperative IOP was 26.0 on an average of 2.8 medications. At 6 months, the average IOP dropped to 16.7 on 0.9 medications and stayed relatively stable at 15.8 on 1.2 medications at 12-month follow-up. The M4 valve appears to have less of a hypertensive phase compared with the other Ahmed class valves with a similar safety profile. While 71.5% success rate was achieved at final follow-up, the failure rate steadily increased over time. While the M4 production has been discontinued, the porous design of the M4 may avoid a pressure spike in the Ahmed valve class and warrants future investigation for valve design. How to cite this article: Sluch I, Gudgel B, Dvorak J, Ahluwalia MA, Ding K, Vold S, Sarkisian S. Clinical Experience with the M4 Ahmed Glaucoma Drainage Implant. J Curr Glaucoma Pract 2017;11(3):92-96.

A European Multicenter Study of 616 Patients Receiving the Freedom Solo Stentless Bioprosthesis.

PubMed

Thalmann, Markus; Grubitzsch, Herko; Matschke, Klaus; Glauber, Mattia; Tan, Erwin; Francois, Katrien; Amorim, Mario J; Hensens, Ab G; Cesari, Francesco; Feyrer, Richard; Diegeler, Anno; Veit, Franz; Repossini, Alberto

2016-01-01

The purpose of this study was to evaluate the safety and performance of the Freedom Solo valve in aortic valve replacement by clinical and hemodynamic outcomes. Six hundred sixteen patients underwent aortic valve replacement in 18 European centers; mean age was 74.5 ± 5.9 years, 54.1% of the patients were male, and concomitant procedures were performed in 43.2% of the patients. The majority (69%) of the implanted sizes were 23 mm and 25 mm. At 1 year, overall survival was 94.0%, whereas freedom from valve-related death was 98.6%. There were 9 (1.5%) early (≤ 30 days) and 27 (4.4%) late (>30 days) deaths. Early and late valve-related mortality was 0.3% (n = 2) and 1.1% (n = 7), respectively. Freedom from explant was 97.6%; 10 valves were explanted for endocarditis and 4 for paravalvular leak. There were 10 (1.6%) early and 5 (0.8%) late strokes. Atrioventricular block requiring pacemaker implant occurred in 8 (1.3%) and 1 (0.2%) patients in the early and late postoperative period, respectively. Thrombocytopenia was seen in 27 cases (4.4%) in the early postoperative period. Preoperatively, 93.8% of patients were in New York Heart Association functional classes II through IV, whereas at 1 year 96.9% of patients were in New York Heart Association functional classes I and II. At 1-year follow-up, mean and peak pressure gradients were 7.2 and 14.6 mm Hg, respectively. Indexed left ventricular mass decreased by 12% from 138 g/m(2) at discharge to 122 g/m(2) at 1 year. At 1-year follow-up after Freedom Solo implantation, we found acceptable clinical results with low mortality and morbidity and good hemodynamic performance, confirming safety and effectiveness in this multicenter experience. Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Mortality after percutaneous edge-to-edge mitral valve repair: a contemporary review.

PubMed

Kortlandt, Friso A; de Beenhouwer, Thomas; Swaans, Martin J; Post, Marco C; van der Heyden, Jan A S; Eefting, Frank D; Rensing, Benno J W M

2016-04-01

Percutaneous edge-to-edge mitral valve (MV) repair is a relatively new treatment option for mitral regurgitation (MR). After the feasibility and safety having been proved in low-surgical-risk patients, the use of this procedure has shifted more to the treatment of high-risk patients. With the absence of randomized controlled trials (RCT) for this particular subgroup, observational studies try to add evidence to the safety aspect of this procedure. These also provide short- and mid-term mortality figures. Several mortality predictors have been identified, which may help the optimal selection of patients who will benefit most from this technique. In this article we provide an overview of the literature about mortality and its predictors in patients treated with the percutaneous edge-to-edge device.

Single and two-phase flows of shear-thinning media in safety valves.

PubMed

Moncalvo, D; Friedel, L

2009-09-15

This study is the first one in the scientific literature to investigate the liquid and two-phase flows of shear-thinning media, here aqueous solutions of polyvinylpyrrolidone, in a fully opened safety valve. In liquid flows the volume flux at the valve seat does not show any appreciable reduction when increasing the percental weight of polymer in the solution. This result may suggest that the viscous losses in the valve do not increase sensibly from the most aqueous to the most viscous solution. The authors explain it considering that in the region between the seat and the disk, where large pressure and velocity gradients occur, large shear rates are expected. On behalf of the rheological measurements, which show that both the pseudoplasticity and the zero-shear viscosity of the solutions increase with the polymer weight, the difference between the viscosities of the most viscous and those of the most aqueous solution is between the seat and the disk far less than that existing at zero-shear condition. Therefore, the effective viscous pressure drop of the safety valve, which occurs mostly in that region, must increase only modestly with the polymer percental weight in the solution. In two-phase flows the total mass flow rate at constant quality and constant relieving pressure increases remarkably with the polymer weight. The analogy with similar results in cocurrent pipe flows suggests that air entrainment causes large velocity gradients in the liquids and strains them to very large shear rates. It suggests also that a redistribution of the gas agglomerates within the liquid must be expected when increasing the polymer weight in the solutions. In fact, the gas agglomerates react to the larger viscous drag of the liquid by compressing their volume in order to exert a higher internal pressure. The reduction of the void fraction of the mixture at constant quality and constant relieving pressure imposes an increment in the total mass flow rate, since otherwise it would lead to a reduction in the momentum of the mixture and therefore to a drop in the relieving pressure.

Revisiting Sex Equality With Transcatheter Aortic Valve Replacement Outcomes: A Collaborative, Patient-Level Meta-Analysis of 11,310 Patients.

PubMed

O'Connor, Stephen A; Morice, Marie-Claude; Gilard, Martine; Leon, Martin B; Webb, John G; Dvir, Danny; Rodés-Cabau, Josep; Tamburino, Corrado; Capodanno, Davide; D'Ascenzo, Fabrizio; Garot, Philippe; Chevalier, Bernard; Mikhail, Ghada W; Ludman, Peter F

2015-07-21

There has been conflicting clinical evidence as to the influence of female sex on outcomes after transcatheter aortic valve replacement. The aim of this study was to evaluate the impact of sex on early and late mortality and safety end points after transcatheter aortic valve replacement using a collaborative meta-analysis of patient-level data. From the MEDLINE, Embase, and the Cochrane Library databases, data were obtained from 5 studies, and a database containing individual patient-level time-to-event data was generated from the registry of each selected study. The primary outcome of interest was all-cause mortality. The safety end point was the combined 30-day safety end points of major vascular complications, bleeding events, and stroke, as defined by the Valve Academic Research Consortium when available. Five studies and their ongoing registry data, comprising 11,310 patients, were included. Women constituted 48.6% of the cohort and had fewer comorbidities than men. Women had a higher rate of major vascular complications (6.3% vs. 3.4%; p < 0.001), major bleeding events (10.5% vs. 8.5%; p = 0.003), and stroke (4.4% vs. 3.6%; p = 0.029) but a lower rate of significant aortic incompetence (grade ≥2; 19.4% vs. 24.5%; p < 0.001). There were no differences in procedural and 30-day mortality between women and men (2.6 % vs. 2.2% [p = 0.24] and 6.5% vs. 6.5% [p = 0.93], respectively), but female sex was independently associated with improved survival at median follow-up of 387 days (interquartile range: 192 to 730 days) from the index procedure (adjusted hazard ratio: 0.79; 95% confidence interval: 0.73 to 0.86; p = 0.001). Although women experience more bleeding events, as well as vascular and stroke complications, female sex is an independent predictor of late survival after transcatheter aortic valve replacement. This should be taken into account during patient selection for this procedure. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Myocardial Protection and Financial Considerations of Custodiol Cardioplegia in Minimally Invasive and Open Valve Surgery.

PubMed

Hummel, Brian W; Buss, Randall W; DiGiorgi, Paul L; Laviano, Brittany N; Yaeger, Nalani A; Lucas, M Lee; Comas, George M

Single-dose antegrade crystalloid cardioplegia with Custodiol-HTK (histidine-tryptophan-ketoglutarate) has been used for many years. Its safety and efficacy were established in experimental and clinical studies. It is beneficial in complex valve surgery because it provides a long period of myocardial protection with a single dose. Thus, valve procedures (minimally invasive or open) can be performed with limited interruption. The aim of this study is to compare the use of Custodiol-HTK cardioplegia with traditional blood cardioplegia in patients undergoing minimally invasive and open valve surgery. A single-institution, retrospective case-control review was performed on patients who underwent valve surgery in Lee Memorial Health System at either HealthPark Medical Center or Gulf Coast Medical Center from July 1, 2011, through March 7, 2015. A total of 181 valve cases (aortic or mitral) performed using Custodiol-HTK cardioplegia were compared with 181 cases performed with traditional blood cardioplegia. Each group had an equal distribution of minimally invasive and open valve cases. Right chest thoracotomy or partial sternotomy was performed on minimally invasive valve cases. Demographics, perioperative data, clinical outcomes, and financial data were collected and analyzed. Patient outcomes were superior in the Custodiol-HTK cardioplegia group for blood transfusion, stroke, and hospital readmission within 30 days (P < 0.05). No statistical differences were observed in the other outcomes categories. Hospital charges were reduced on average by $3013 per patient when using Custodiol-HTK cardioplegia. Use of Custodiol-HTK cardioplegia is safe and cost-effective when compared with traditional repetitive blood cardioplegia in patients undergoing minimally invasive and open valve surgery.

Dynamic performance of high speed solenoid valve with parallel coils

NASA Astrophysics Data System (ADS)

Kong, Xiaowu; Li, Shizhen

2014-07-01

The methods of improving the dynamic performance of high speed on/off solenoid valve include increasing the magnetic force of armature and the slew rate of coil current, decreasing the mass and stroke of moving parts. The increase of magnetic force usually leads to the decrease of current slew rate, which could increase the delay time of the dynamic response of solenoid valve. Using a high voltage to drive coil can solve this contradiction, but a high driving voltage can also lead to more cost and a decrease of safety and reliability. In this paper, a new scheme of parallel coils is investigated, in which the single coil of solenoid is replaced by parallel coils with same ampere turns. Based on the mathematic model of high speed solenoid valve, the theoretical formula for the delay time of solenoid valve is deduced. Both the theoretical analysis and the dynamic simulation show that the effect of dividing a single coil into N parallel sub-coils is close to that of driving the single coil with N times of the original driving voltage as far as the delay time of solenoid valve is concerned. A specific test bench is designed to measure the dynamic performance of high speed on/off solenoid valve. The experimental results also prove that both the delay time and switching time of the solenoid valves can be decreased greatly by adopting the parallel coil scheme. This research presents a simple and practical method to improve the dynamic performance of high speed on/off solenoid valve.

Outcomes With Transcatheter Mitral Valve Repair in the United States: An STS/ACC TVT Registry Report.

PubMed

Sorajja, Paul; Vemulapalli, Sreekanth; Feldman, Ted; Mack, Michael; Holmes, David R; Stebbins, Amanda; Kar, Saibal; Thourani, Vinod; Ailawadi, Gorav

2017-11-07

Post-market surveillance is needed to evaluate the real-world clinical effectiveness and safety of U.S. Food and Drug Administration-approved devices. The authors examined the commercial experience with transcatheter mitral valve repair for the treatment of mitral regurgitation. Data from the Society of Thoracic Surgery/American College of Cardiology Transcatheter Valve Therapy Registry on patients commercially treated with transcatheter mitral valve repair were analyzed. The study population consisted of 2,952 patients treated at 145 hospitals between November 2013 and September 2015. In 1,867 patients, data were linked to patient-specific Centers for Medicare and Medicaid Services administrative claims for analyses. The median age was 82 years (55.8% men), with a median Society of Thoracic Surgery predicted risk of mortality of 6.1% (interquartile range: 3.7% to 9.9%) and 9.2% (interquartile range: 6.0% to 14.1%) for mitral repair and replacement, respectively. Overall, in-hospital mortality was 2.7%. Acute procedure success occurred in 91.8%. Among the patients with Centers for Medicare and Medicaid Services linkage data, the mortality at 30 days and at 1 year was 5.2% and 25.8%, respectively, and repeat hospitalization for heart failure at 1 year occurred in 20.2%. Variables associated with mortality or rehospitalization for heart failure after multivariate adjustment were increasing age, lower baseline left ventricular ejection fraction, worse post-procedural mitral regurgitation, moderate or severe lung disease, dialysis, and severe tricuspid regurgitation. Our findings demonstrate that commercial transcatheter mitral valve repair is being performed in the United States with acute effectiveness and safety. Our findings may help determine which patients have favorable long-term outcomes with this therapy. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Right mini-parasternotomy may be a good minimally invasive alternative to full sternotomy for cardiac valve operations-a propensity-adjusted analysis.

PubMed

Chiu, K M; Chen, R J; Lin, T Y; Chen, J S; Huang, J H; Huang, C Y; Chu, S H

2014-03-26

Limited realworld data existed for miniparasternotomy approach with good sample size in Asian cohorts and most previous studies were eclipsed by case heterogeneity. The goal of this study was to compare safety and quality outcomes of cardiac noncoronary valve operations by miniparasternotomy and full sternotomy approaches on riskadjusted basis. From our hospital database, we retrieved the cases of non-coronary valve operations from 1 January 2005 to 31 December 2012, including re-do, emergent, and combined procedures. Estimated EuroScore-II and propensity score for choosing mini-parasternotomy were adjusted for in the regression models on hospital mortality, complications (pneumonia, stroke, sepsis, etc.), and quality parameters (length of stay, ICU time, ventilator time, etc.). Non-complicated cases, defined as survival to discharge, ventilator use not over one week, and intensive care unit stay not over two weeks, were used for quality parameters. There were 283 miniparasternotomy and 177 full sternotomy cases. EuroScore-II differed significantly (medians 2.1 vs. 4.7, p<0.001). Propensity scores for choosing miniparasternotomy were higher with lower EuroScore-II (OR=0.91 per 1%, p<0.001), aortic regurgitation (OR=2.3, p=0.005), and aortic non-mitral valve disease (OR=3.9, p<0.001). Adjusted for propensity score and EuroScore-II, mini-parasternotomy group had less pneumonia (OR=0.32, p=0.043), less sepsis (OR=0.31, p=0.045), and shorter non-complicated length of stay (coefficient=7.2 (day), p<0.001) than full sternotomy group, whereas Kaplan-Meier survival, non-complicated ICU time, non-complicated ventilator time, and 30-day mortality did not differ significantly. The propensity-adjusted analysis demonstrated encouraging safety and quality outcomes for mini-parasternotomy valve operation in carefully selected patients.

Saturn Orbits Car Making into the Twenty-First Century. A Case Study

DTIC Science & Technology

1993-04-01

two engine variations of the 1.9 liter four-cylinder aluminum block, a standard 85-horsepower, single overhead camshaft (SOHC) 8-valve and a high...performance, 124-horsepower, dual overhead camshafts (DOHC) 16-valve version. Its optional anti-lock braking system was a safety addition not normally found...Treece, James B. "The Planets May be Perfectly Aligned For Saturn’s Lift-Off." Business Week Oct. 22, 1990: 40. Tree %.e, James B. "War, Recession

Memory Metals (MEMRYSAFE, FIRECHEK, ULTRAVALVE)

NASA Technical Reports Server (NTRS)

1991-01-01

A NASA contract led Memry Corporation to the development of commercial products based upon Shape Memory Effect, or the ability of certain metal alloys to change from one shape to another with temperature changes. MEMRYSAFE instantly restricts water flow in shower or sinks before scalding. ULTRAVALVE allows a user to preselect a bathing temperature. FIRECHEK is a fire control safety valve that detects unsafe temperatures and shuts off pneumatic pressure that operates control valves in industrial process lines containing hazardous gases or fluids.

49 CFR 179.400-21 - Test of pressure relief valves.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and...

46 CFR 98.25-15 - Markings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... safety relief valves, liquid level gaging devices and pressure gages shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of noncorrosive material may be attached to...

46 CFR 98.25-15 - Markings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... safety relief valves, liquid level gaging devices and pressure gages shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of noncorrosive material may be attached to...

46 CFR 98.25-15 - Markings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... safety relief valves, liquid level gaging devices and pressure gages shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of noncorrosive material may be attached to...

46 CFR 98.25-15 - Markings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... safety relief valves, liquid level gaging devices and pressure gages shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of noncorrosive material may be attached to...

46 CFR 98.25-15 - Markings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... safety relief valves, liquid level gaging devices and pressure gages shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of noncorrosive material may be attached to...

Justice Safety Valve Act of 2013

THOMAS, 113th Congress

Rep. Scott, Robert C. "Bobby" [D-VA-3

2013-04-24

House - 06/14/2013 Referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Advances in Multiphase Flow and Transport in the Subsurface Environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shi, Xiaoqing; Finsterle, Stefan; Zhang, Keni

Multiphase flow and transport processes in the subsurface environment are extremely important in a number of industrial and environmental applications at various spatial and temporal scales. Thus, it is necessary to identify, understand, and predict these processes to improve the production of conventional and unconventional oil and gas, to increase the safety of geological sequestration of carbon dioxide and nuclear waste disposal, and to make remediation of contaminated aquifers more effective.

Advances in Multiphase Flow and Transport in the Subsurface Environment

DOE PAGES

Shi, Xiaoqing; Finsterle, Stefan; Zhang, Keni; ...

2018-03-04

Multiphase flow and transport processes in the subsurface environment are extremely important in a number of industrial and environmental applications at various spatial and temporal scales. Thus, it is necessary to identify, understand, and predict these processes to improve the production of conventional and unconventional oil and gas, to increase the safety of geological sequestration of carbon dioxide and nuclear waste disposal, and to make remediation of contaminated aquifers more effective.

Chemical technology for the toxic gas flow control through process water system.

PubMed

Broussard, G; Bramanti, O; Salvatore, A; Marchese, F M

2001-01-01

The aim of this work is focused on the safety and toxicological aspects due to under-pressure industrial plant management, above all in the case which the gas is very dangerous for human health and environment. Here is illustrated the safe method of control of risks through specific choices of engineering devices and chemical process: in this way we have shown the mathematical calculation regarding the case of ammonia flow gas running in the piping and plant under-pressure. In this paper the Authors show the assessment of the technological solution for falling down of a toxic gas as NH3, which lets off from safety values facilities. The under pressure industrial plants with ammonia are protected through the safety valves, settled at 20 bar pressure. The out-let gas flow is capted by a tank of a water bulk of five time theoretical water amount necessary to the complete absorption of gas. In order to prevent any health risk and carry out a safety management, it needs to verify two basic aspects, with connected specific techniques: 1. The safety valves technology through the mathematical calculation of operating device; 2. The absorption process of the toxic agent for controlling of dangerous runaway of gas.

49 CFR 192.383 - Excess flow valve installation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Customer Meters, Service Regulators... psig or greater throughout the year; (2) The operator has prior experience with contaminants in the gas...

A 1064 nm dispersive Raman spectral imaging system for food safety and quality evaluation

USDA-ARS?s Scientific Manuscript database

Raman spectral imaging is an effective method to analyze and evaluate chemical composition and structure of a sample, and has many applications for food safety and quality research. This study developed a 1064 nm Raman spectral imaging system for surface and subsurface analysis of food samples. A 10...

Solvent Recycling for Shipyards

DTIC Science & Technology

1993-05-01

Suvey results are included in Section 5) Survey manufacturers and compile information on available equipment and features . (Data is summarized in Section...should be placed on safety features . Important safety features include explosion-proof electricals and grounding protection, overpressure relief valves...solvent can dissolve a polymer plastic liner, or extract water from a clay liner, resulting in liner leakage. The threat is compounded by the ability

Safety Aspects of Big Cryogenic Systems Design

NASA Astrophysics Data System (ADS)

Chorowski, M.; Fydrych, J.; Poliński, J.

2010-04-01

Superconductivity and helium cryogenics are key technologies in the construction of large scientific instruments, like accelerators, fusion reactors or free electron lasers. Such cryogenic systems may contain more than hundred tons of helium, mostly in cold and high-density phases. In spite of the high reliability of the systems, accidental loss of the insulation vacuum, pipe rupture or rapid energy dissipation in the cold helium can not be overlooked. To avoid the danger of over-design pressure rise in the cryostats, they need to be equipped with a helium relief system. Such a system is comprised of safety valves, bursting disks and optionally cold or warm quench lines, collectors and storage tanks. Proper design of the helium safety relief system requires a good understanding of worst case scenarios. Such scenarios will be discussed, taking into account different possible failures of the cryogenic system. In any case it is necessary to estimate heat transfer through degraded vacuum superinsulation and mass flow through the valves and safety disks. Even if the design of the helium relief system does not foresee direct helium venting into the environment, an occasional emergency helium spill may happen. Helium propagation in the atmosphere and the origins of oxygen-deficiency hazards will be discussed.

Design of the Electronic Brake Pressure Modulator Using a Direct Adaptive Fuzzy Controller in Commercial Vehicles for the Safety of Braking in Fail

NASA Astrophysics Data System (ADS)

Kim, Hunmo

In the brake systems, it is important to reduce the rear brake pressure in order to secure the safety of the vehicle in braking. So, there was some research that reduced and controlled the rear brake pressure exactly like a L. S. P. V and a E. L. S. P. V. However, the previous research has some weaknesses: the L. S. P. V is a mechanical system and its brake efficiency is lower than the efficiency of E. L. S. P. V. But, the cost of E. L. S. P. V is very higher so its application to the vehicle is very difficult. Additionally, when a fail appears in the circuit which controls the valves, the fail results in some wrong operation of the valves. But, the previous researchers didn't take the effect of fail into account. Hence, the efficiency of them is low and the safety of the vehicle is not confirmed. So, in this paper we develop a new economical pressure modulator that exactly controls brake pressure and confirms the safety of the vehicle in any case using a direct adaptive fuzzy controller.

46 CFR 38.05-5 - Markings-TB/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., except safety relief valves, liquid level gaging devices, and pressure gages, shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of corrosion-resistant material may be...

46 CFR 38.05-5 - Markings-TB/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., except safety relief valves, liquid level gaging devices, and pressure gages, shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of corrosion-resistant material may be...

46 CFR 38.05-5 - Markings-TB/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., except safety relief valves, liquid level gaging devices, and pressure gages, shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of corrosion-resistant material may be...

46 CFR 38.05-5 - Markings-TB/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., except safety relief valves, liquid level gaging devices, and pressure gages, shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of corrosion-resistant material may be...

46 CFR 38.05-5 - Markings-TB/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., except safety relief valves, liquid level gaging devices, and pressure gages, shall be labeled to designate whether they terminate in the vapor or liquid space. Labels of corrosion-resistant material may be...

49 CFR 179.200-23 - Tests of pressure relief valves.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200...

46 CFR 151.20-10 - Cargo system instrumentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... remote reading temperature sensor located in the liquid phase of the cargo. The temperature gauge shall..., each tank equipped with safety relief valves shall be fitted with a pressure gauge which shall be...

Coincident steam generator tube rupture and stuck-open safety relief valve carryover tests: MB-2 steam generator transient response test program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garbett, K; Mendler, O J; Gardner, G C

In PWR steam generator tube rupture (SGTR) faults, a direct pathway for the release of radioactive fission products can exist if there is a coincident stuck-open safety relief valve (SORV) or if the safety relief valve is cycled. In addition to the release of fission products from the bulk steam generator water by moisture carryover, there exists the possibility that some primary coolant may be released without having first mixed with the bulk water - a process called primary coolant bypassing. The MB-2 Phase II test program was designed specifically to identify the processes for droplet carryover during SGTR faultsmore » and to provide data of sufficient accuracy for use in developing physical models and computer codes to describe activity release. The test program consisted of sixteen separate tests designed to cover a range of steady-state and transient fault conditions. These included a full SGTR/SORV transient simulation, two SGTR overfill tests, ten steady-state SGTR tests at water levels ranging from very low levels in the bundle up to those when the dryer was flooded, and three moisture carryover tests without SGTR. In these tests the influence of break location and the effect of bypassing the dryer were also studied. In a final test the behavior with respect to aerosol particles in a dry steam generator, appropriate to a severe accident fault, was investigated.« less

The development of a Martian atmospheric Sample collection canister

NASA Astrophysics Data System (ADS)

Kulczycki, E.; Galey, C.; Kennedy, B.; Budney, C.; Bame, D.; Van Schilfgaarde, R.; Aisen, N.; Townsend, J.; Younse, P.; Piacentine, J.

The collection of an atmospheric sample from Mars would provide significant insight to the understanding of the elemental composition and sub-surface out-gassing rates of noble gases. A team of engineers at the Jet Propulsion Laboratory (JPL), California Institute of Technology have developed an atmospheric sample collection canister for Martian application. The engineering strategy has two basic elements: first, to collect two separately sealed 50 cubic centimeter unpressurized atmospheric samples with minimal sensing and actuation in a self contained pressure vessel; and second, to package this atmospheric sample canister in such a way that it can be easily integrated into the orbiting sample capsule for collection and return to Earth. Sample collection and integrity are demonstrated by emulating the atmospheric collection portion of the Mars Sample Return mission on a compressed timeline. The test results achieved by varying the pressure inside of a thermal vacuum chamber while opening and closing the valve on the sample canister at Mars ambient pressure. A commercial off-the-shelf medical grade micro-valve is utilized in the first iteration of this design to enable rapid testing of the system. The valve has been independently leak tested at JPL to quantify and separate the leak rates associated with the canister. The results are factored in to an overall system design that quantifies mass, power, and sensing requirements for a Martian atmospheric Sample Collection (MASC) canister as outlined in the Mars Sample Return mission profile. Qualitative results include the selection of materials to minimize sample contamination, preliminary science requirements, priorities in sample composition, flight valve selection criteria, a storyboard from sample collection to loading in the orbiting sample capsule, and contributions to maintaining “ Earth” clean exterior surfaces on the orbiting sample capsule.

30 CFR 250.801 - Subsurface safety devices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... permafrost, unstable bottom conditions, hydrate formation, or paraffins, an alternate setting depth of the..., when warranted by conditions such as permafrost, unstable bottom conditions, hydrate formations, and...

Survey Plan For Characterization of the Subsurface Underlying the National Aeronautics and Space Administration's Marshall Space Flight Center in Huntsville, Alabama. Volume 1 and 2

NASA Technical Reports Server (NTRS)

1996-01-01

Topic considered include: survey objectives; technologies for non-Invasive imaging of subsurface; cost; data requirements and sources; climatic condition; hydrology and geology; chemicals; magnetometry; electrical(resistivity, potential); optical-style imaging; reflection/refraction seismics; gravitometry; photo-acoustic activation;well drilling and borehole analysis; comparative assessment matrix; ground sensors; choice of the neutron sources; logistic of operations; system requirements; health and safety plans.

The WISDOM Radar: Unveiling the Subsurface Beneath the ExoMars Rover and Identifying the Best Locations for Drilling

NASA Astrophysics Data System (ADS)

Ciarletti, Valérie; Clifford, Stephen; Plettemeier, Dirk; Le Gall, Alice; Hervé, Yann; Dorizon, Sophie; Quantin-Nataf, Cathy; Benedix, Wolf-Stefan; Schwenzer, Susanne; Pettinelli, Elena; Heggy, Essam; Herique, Alain; Berthelier, Jean-Jacques; Kofman, Wlodek; Vago, Jorge L.; Hamran, Svein-Erik; WISDOM Team

2017-07-01

The search for evidence of past or present life on Mars is the principal objective of the 2020 ESA-Roscosmos ExoMars Rover mission. If such evidence is to be found anywhere, it will most likely be in the subsurface, where organic molecules are shielded from the destructive effects of ionizing radiation and atmospheric oxidants. For this reason, the ExoMars Rover mission has been optimized to investigate the subsurface to identify, understand, and sample those locations where conditions for the preservation of evidence of past life are most likely to be found. The Water Ice Subsurface Deposit Observation on Mars (WISDOM) ground-penetrating radar has been designed to provide information about the nature of the shallow subsurface over depth ranging from 3 to 10 m (with a vertical resolution of up to 3 cm), depending on the dielectric properties of the regolith. This depth range is critical to understanding the geologic evolution stratigraphy and distribution and state of subsurface H2O, which provide important clues in the search for life and the identification of optimal drilling sites for investigation and sampling by the Rover's 2-m drill. WISDOM will help ensure the safety and success of drilling operations by identification of potential hazards that might interfere with retrieval of subsurface samples.

49 CFR 179.200-23 - Tests of pressure relief valves.

Code of Federal Regulations, 2013 CFR

2013-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-23 Tests of...

49 CFR 179.200-23 - Tests of pressure relief valves.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-23 Tests of...

49 CFR 179.200-23 - Tests of pressure relief valves.

Code of Federal Regulations, 2014 CFR

2014-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-23 Tests of...

A novel v- silicone vestibular stent: preventing vestibular stenosis and preserving nasal valves.

PubMed

Bassam, Wameedh Al; Bhargava, Deepa; Al-Abri, Rashid

2012-01-01

This report presents a novel style of placing nasal stents. Patients undergoing surgical procedures in the region of nasal vestibule and nasal valves are at risk of developing vestibular stenosis and lifelong problems with the external and internal nasal valves; sequels of the repair. The objective of the report is to demonstrate a simple and successful method of an inverted V- Stent placement to prevent potential complication of vestibular stenosis and nasal valve compromise later in life. Following a fall on a sharp edge of a metallic bed, a sixteen month old child with a deep lacerated nasal wound extending from the collumellar base toward the tip of the nose underwent surgical exploration and repair of the nasal vestibule and nasal cavity. A soft silicone stent fashioned as inverted V was placed bilaterally. The child made a remarkable recovery with no evidence of vestibular stenosis or nasal valve abnormalities. In patients with nasal trauma involving the nasal vestibule and internal and external nasal valves stent placement avoids sequels, adhesions, contractures, synechia vestibular stenosis and fibrosis involving these anatomical structures. The advantages of the described V- stents over the traditional readymade ridged nasal stents, tubing's and composite aural grafts are: a) technical simplicity of use, b) safety, c) less morbidity, d) more comfortable, and e) economical. To our knowledge, this is the first report of such a stent for prevention of vestibular stenosis and preserving nasal valves.

A Novel V- Silicone Vestibular Stent: Preventing Vestibular Stenosis and Preserving Nasal Valves

PubMed Central

Bassam, Wameedh AL; Bhargava, Deepa; Al-Abri, Rashid

2012-01-01

This report presents a novel style of placing nasal stents. Patients undergoing surgical procedures in the region of nasal vestibule and nasal valves are at risk of developing vestibular stenosis and lifelong problems with the external and internal nasal valves; sequels of the repair. The objective of the report is to demonstrate a simple and successful method of an inverted V- Stent placement to prevent potential complication of vestibular stenosis and nasal valve compromise later in life. Following a fall on a sharp edge of a metallic bed, a sixteen month old child with a deep lacerated nasal wound extending from the collumellar base toward the tip of the nose underwent surgical exploration and repair of the nasal vestibule and nasal cavity. A soft silicone stent fashioned as inverted V was placed bilaterally. The child made a remarkable recovery with no evidence of vestibular stenosis or nasal valve abnormalities. In patients with nasal trauma involving the nasal vestibule and internal and external nasal valves stent placement avoids sequels, adhesions, contractures, synechia vestibular stenosis and fibrosis involving these anatomical structures. The advantages of the described V- stents over the traditional readymade ridged nasal stents, tubing’s and composite aural grafts are: a) technical simplicity of use, b) safety, c) less morbidity, d) more comfortable, and e) economical. To our knowledge, this is the first report of such a stent for prevention of vestibular stenosis and preserving nasal valves. PMID:22359729

Maintenance of valvular integrity with Impella left heart support: Results from the multicenter PROTECT II randomized study.

PubMed

Goldstein, James A; Dixon, Simon R; Douglas, Pamela S; Ohman, E Magnus; Moses, Jeffrey; Popma, Jeffrey J; O'Neill, William W

2017-10-08

The Impella 2.5 axial flow pump, which is positioned across the aortic valve, is widely employed for hemodynamic support. The present study compared structural and functional integrity of the left heart valves in patients undergoing Impella vs intra-aortic balloon pump in the randomized PROTECT II trial. Transthoracic echocardiograms were performed at baseline, 1 and 3 months in 445 patients in the PROTECT II trial. Serial studies were analyzed by an independent echocardiography core laboratory for aortic and mitral valve structure and function, and left ventricular ejection fraction (LVEF). During Impella support there was no appreciable change in the degree of baseline valvular regurgitation. There were no cases of structural derangement of the mitral or aortic valve after use of the Impella device. At 90-day follow-up, there was an average 22% relative increase in LVEF from baseline (27% ± 9 vs. 33% ± 11, P < 0.001). The present echocardiographic analysis of the PROTECT II study confirms prior observations regarding the safety of the Impella 2.5 device with respect to mitral and aortic valve function. © 2017 Wiley Periodicals, Inc.

Subsea pipeline isolation systems: Reliability and costs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Masheder, R.R.

1995-12-31

On the night of 6/7 July 1988 a major oil production platform known as Piper Alpha in the UK sector of the North Sea was destroyed by explosion and fire, with the loss of 167 lives. This led to the appointment of Lord Cullen, a senior Scottish Judge, to hold a Public Inquiry into the Piper Alpha Disaster. The Cullen Enquiry Report consisting of 23 chapters set out in 2 volumes, was published on 12 November 1990. One of the important conclusions drawn by Lord Cullen resulted in a recommendation for studies to be conducted to consider ways of improvingmore » the reliability and reducing the costs of SSIVs (Subsea Isolation Valves) so that it is more often reasonably practicable to install them. To address the Cullen recommendations, a joint industry study was conducted by UKOOA (United Kingdom Offshore Operators Association) and the HSE/OSD (Health and Safety Executive Offshore Safety Division) in conjunction with independent consultants. The results of the studies and the conclusions drawn by UKOOA Pipeline Valve Group and the HSE Offshore Safety Division are presented in this paper.« less

46 CFR 154.1846 - Relief valves: Changing set pressure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1846...) Ensure that a sign showing the set pressure is posted: (1) In the cargo control room or station; and (2...

46 CFR 154.1846 - Relief valves: Changing set pressure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1846...) Ensure that a sign showing the set pressure is posted: (1) In the cargo control room or station; and (2...

Balloon expandable transcatheter aortic valve implantation with or without pre-dilation of the aortic valve - rationale and design of a multicenter registry (EASE-IT).

PubMed

Bramlage, Peter; Strauch, Justus; Schröfel, Holger

2014-11-18

In patients with severe calcific aortic stenosis, balloon aortic valvuloplasty (BAV) is routinely performed in order to pre-dilate the stenosed aortic valve prior to transcatheter aortic valve implantation (TAVI). Although pre-dilation is considered to be essential for the preparation of the valve landing zone, there is no clear evidence to support its clinical value. In contrast, BAV has been suggested to be linked to several complications. Notably, while preliminary evidence has supported the feasibility and safety of TAVI without pre-dilation, larger studies directly comparing the benefit/risk profile of TAVI in the presence and absence of pre-dilation are required. Therefore, a prospective, two-armed, multicenter registry (EASE-IT) was designed to obtain essential data concerning procedural success rates, adverse events, and mortality in a large cohort of patients undergoing transapical (TA)-TAVI using the Edwards SAPIEN 3 balloon expandable heart valves with and without pre-ballooning. Data provided by EASE-IT will be used to assess the relevance of BAV during the TAVI procedure and to investigate associations between patient characteristics and outcomes. Therefore, results obtained from the EASE-IT registry could contribute to reduced rates of TAVI-associated morbidity and mortality in patients with severe, calcific aortic stenosis. ClinicalTrials.gov Identifier: NCT02127580.

Percutaneous repair or surgery for mitral regurgitation.

PubMed

Feldman, Ted; Foster, Elyse; Glower, Donald D; Glower, Donald G; Kar, Saibal; Rinaldi, Michael J; Fail, Peter S; Smalling, Richard W; Siegel, Robert; Rose, Geoffrey A; Engeron, Eric; Loghin, Catalin; Trento, Alfredo; Skipper, Eric R; Fudge, Tommy; Letsou, George V; Massaro, Joseph M; Mauri, Laura

2011-04-14

Mitral-valve repair can be accomplished with an investigational procedure that involves the percutaneous implantation of a clip that grasps and approximates the edges of the mitral leaflets at the origin of the regurgitant jet. We randomly assigned 279 patients with moderately severe or severe (grade 3+ or 4+) mitral regurgitation in a 2:1 ratio to undergo either percutaneous repair or conventional surgery for repair or replacement of the mitral valve. The primary composite end point for efficacy was freedom from death, from surgery for mitral-valve dysfunction, and from grade 3+ or 4+ mitral regurgitation at 12 months. The primary safety end point was a composite of major adverse events within 30 days. At 12 months, the rates of the primary end point for efficacy were 55% in the percutaneous-repair group and 73% in the surgery group (P=0.007). The respective rates of the components of the primary end point were as follows: death, 6% in each group; surgery for mitral-valve dysfunction, 20% versus 2%; and grade 3+ or 4+ mitral regurgitation, 21% versus 20%. Major adverse events occurred in 15% of patients in the percutaneous-repair group and 48% of patients in the surgery group at 30 days (P<0.001). At 12 months, both groups had improved left ventricular size, New York Heart Association functional class, and quality-of-life measures, as compared with baseline. Although percutaneous repair was less effective at reducing mitral regurgitation than conventional surgery, the procedure was associated with superior safety and similar improvements in clinical outcomes. (Funded by Abbott Vascular; EVEREST II ClinicalTrials.gov number, NCT00209274.).

Minimally invasive right lateral thoracotomy without aortic cross-clamping: an attractive alternative to repeat sternotomy for reoperative mitral valve surgery.

PubMed

Umakanthan, Ramanan; Petracek, Michael R; Leacche, Marzia; Solenkova, Nataliya V; Eagle, Susan S; Thompson, Annemarie; Ahmad, Rashid M; Greelish, James P; Ball, Stephen K; Hoff, Steven J; Absi, Tarek S; Balaguer, Jorge M; Byrne, John G

2010-03-01

The study aim was to determine the safety and benefits of minimally invasive mitral valve surgery without aortic cross-clamping for mitral valve surgery after previous cardiac surgery. Between January 2006 and August 2008, a total of 90 consecutive patients (38 females, 52 males; mean age 66 +/- 9 years) underwent minimally invasive mitral valve surgery after having undergone previous cardiac surgery. Of these patients, 80 (89%) underwent mitral valve replacement and 10 (11%) mitral valve repair utilizing a small (5 cm) right lateral thoracotomy along the 4th or 5th intercostal space under fibrillatory arrest (mean temperature 28 +/- 2 degrees C). The predicted mortality, calculated using the Society of Thoracic Surgeons (STS) algorithm, was compared to the observed mortality. The mean ejection fraction was 45 +/- 13%, mean NYHA class 3 +/- 1, while 66 patients (73%) had previous coronary artery bypass grafting and 37 (41%) had previous valve surgery. Twenty-six patients (29%) underwent non-elective surgery. Cardiopulmonary bypass was instituted through axillary (n = 19), femoral (n = 70) or direct use aortic (n = 1) cannulation. Operative mortality was 2% (2/90), lower than the STS-predicted mortality of 7%. Three patients (3%) developed acute renal failure postoperatively, one patient (1%) required new-onset hemodialysis, and one (1%) developed postoperative stroke. No patients developed postoperative myocardial infarction. The mean postoperative packed red blood cell transfusion requirement at 48 h was 2 +/- 3 units. Minimally invasive right thoracotomy without aortic cross-clamping is an excellent alternative to conventional redo-sternotomy for reoperative mitral valve surgery. The present study confirmed that this technique is safe and effective in reducing operative mortality in high-risk patients undergoing reoperative cardiac surgery.

Proportional assist ventilation system based on proportional solenoid valve control.

PubMed

Lua, A C; Shi, K C; Chua, L P

2001-07-01

A new proportional assist ventilation (PAV) method using a proportional solenoid valve (PSV) to control air supply to patients suffering from respiratory disabilities, was studied. The outlet flow and pressure from the proportional solenoid valve at various air supply pressures were tested and proven to be suitable for pressure and flow control in a PAV system. In vitro tests using a breathing simulator, which has been proven to possess the general characteristics of human respiratory system in spontaneous breathing tests, were conducted and the results demonstrated the viability of this PAV system in normalizing the breathing patterns of patients with abnormally high resistances and elastances as well as neuromuscular weaknesses. With a back-up safety mechanism incorporated in the control program, pressure "run-away" can be effectively prevented and safe operation of the system can be guaranteed.

Right miniparasternotomy may be a good minimally invasive alternative to full sternotomy for cardiac valve operations: a propensity-adjusted analysis.

PubMed

Chiu, Kuan M; Chen, Robert J; Lin, Tzu Y; Chen, Jer S; Huang, Jin H; Huang, Chun Y; Chu, Shu H

2016-02-01

Limited real-world data existed for mini-parasternotomy approach with good sample size in Asian cohorts and most previous studies were eclipsed by case heterogeneity. The goal of this study was to compare safety and quality outcomes of cardiac non-coronary valve operations by mini-parasternotomy and full sternotomy approaches on risk-adjusted basis. METHODS From our hospital database, we retrieved the cases of non-coronary valve operations from 1 January 2005 to 31 December 2012, including re-do, emergent, and combined procedures. Estimated EuroScore-II and propensity score for choosing mini-parasternotomy were adjusted for in the regression models on hospital mortality, complications (pneumonia, stroke, sepsis, etc.), and quality parameters (length of stay, ICU time, ventilator time, etc.). Non-complicated cases, defined as survival to discharge, ventilator use not over one week, and intensive care unit stay not over two weeks, were used for quality parameters. There were 283 mini-parasternotomy and 177 full sternotomy cases. EuroScore-II differed significantly (medians 2.1 vs. 4.7, P<0.001). Propensity scores for choosing mini-parasternotomy were higher with lower EuroScore-II (OR=0.91 per 1%, P<0.001), aortic regurgitation (OR=2.3, P=0.005), and aortic non-mitral valve disease (OR=3.9, P<0.001). Adjusted for propensity score and EuroScore-II, mini-parasternotomy group had less pneumonia (OR=0.32, P=0.043), less sepsis (OR=0.31, P=0.045), and shorter non-complicated length of stay (coefficient=-7.2 (day), P<0.001) than full sternotomy group, whereas Kaplan-Meier survival, non-complicated ICU time, non-complicated ventilator time, and 30-day mortality did not differ significantly. The propensity-adjusted analysis demonstrated encouraging safety and quality outcomes for mini-parasternotomy valve operation in carefully selected patients.

Outcomes following transcatheter aortic valve replacement in patients with native aortic valve regurgitation

PubMed Central

Bob-Manuel, Tamunoinemi; Kadire, Siri; Heckle, Mark R.; Wang, Jiajing

2018-01-01

Due to the absence of annular calcification for device anchoring, it is presumed that transcatheter aortic valve replacement (TAVR) is not suitable for the treatment of native aortic valve regurgitation (NAVR) resulting in very limited data and experience concerning its safety and efficacy. We sought to review published data on the safety and efficacy of TAVR in high-risk patients with NAVR. Studies including case reports, case series and original articles published between 2002 and 2016 on TAVR in patients with NAVR were identified with a systematic electronic search using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Only studies reporting data on demographic and procedural characteristics, management and follow up outcomes were analyzed. A total of 30 publications describing 182 patients were identified. Most patients (54%) were men, with a mean age of 70.1±2.6 years, mean logistic European System for Cardiac Operative Risk Evaluation score (EuroSCORE) of 21.8%±4.5% and mean Society of Thoracic Surgeons (STS) score of 8%±1.8% for mortality. The majority (87%) of patients had severe NAVR with no valvular calcification. TAVR was mostly performed through the femoral (58.8%) and apical (33.1%) approach. Device success, defined by VARC-2, was achieved in 86.3% of our study population. A second valve was required in 17 patients (9.3%) during the index procedure for residual aortic regurgitation or malposition. Post-procedure aortic regurgitation of grade 1 or less was present in 80 patients (81%). Pacemaker implantation was required post procedure in 17 patients (9.3%). The 30-day and 1-year mortality was 11.9% and 16.2%, respectively. TAVR is associated with favorable pacemaker implantation and 1-year mortality rates with a high 30-day mortality among selected patients with NAVR. PMID:29404354

Extended use of percutaneous edge-to-edge mitral valve repair beyond EVEREST (Endovascular Valve Edge-to-Edge Repair) criteria: 30-day and 12-month clinical and echocardiographic outcomes from the GRASP (Getting Reduction of Mitral Insufficiency by Percutaneous Clip Implantation) registry.

PubMed

Attizzani, Guilherme F; Ohno, Yohei; Capodanno, Davide; Cannata, Stefano; Dipasqua, Fabio; Immé, Sebastiano; Mangiafico, Sarah; Barbanti, Marco; Ministeri, Margherita; Cageggi, Anna; Pistritto, Anna Maria; Giaquinta, Sandra; Farruggio, Silvia; Chiarandà, Marta; Ronsivalle, Giuseppe; Schnell, Audrey; Scandura, Salvatore; Tamburino, Corrado; Capranzano, Piera; Grasso, Carmelo

2015-01-01

This study sought to compare, in high-risk patients with 3+ to 4+ mitral regurgitation (MR) dichotomized by baseline echocardiographic features, acute, 30-day, and 12-month outcomes following percutaneous mitral valve repair using the MitraClip. The feasibility and mid-term outcomes after MitraClip implantation in patients with echocardiographic features different from the EVEREST (Endovascular Valve Edge-to-Edge Repair) I and II trials have been scarcely studied. Clinical and echocardiographic outcomes through 12-month follow-up of consecutive patients who underwent MitraClip implantation were obtained from an ongoing prospective registry. Two different groups, divided according to baseline echocardiographic criteria (investigational group [EVERESTOFF] and control group [EVERESTON]), were compared. Seventy-eight patients were included in EVERESTOFF and 93 patients in EVERESTON groups. Important and comparable acute reductions in MR and no clip-related complications were revealed. The primary safety endpoint at 30 days was comparable between groups (2.6% vs. 6.5%, respectively, p = 0.204); in addition, MR reduction was mostly sustained, whereas equivalent improvement in New York Heart Association functional class were demonstrated. Kaplan-Meier freedom from death, surgery for mitral valve dysfunction, or grade ≥3+ MR at 12 months was demonstrated in 71.4% and 76.2%, respectively, in the EVERESTOFF and EVERESTON groups (log rank p = 0.378). Significant improvements in ejection fraction and reduction in left ventricle volumes were demonstrated in both groups over time, but the baseline between-group differences were sustained. MitraClip implantation in patients with expanded baseline echocardiographic features, compared with the control group, was associated with similar rates of safety and efficacy through 12-month follow-up. Further validation of our findings is warranted. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

29 CFR 1910.103 - Hydrogen.

Code of Federal Regulations, 2011 CFR

2011-07-01

... containers, pressure regulators, safety relief devices, manifolds, interconnecting piping and controls. The... against physical damage and against tampering. (d) Cabinets or housings containing hydrogen control or... valve shall be of the remote control type with no connections, flanges, or other appurtenances (other...

29 CFR 1910.103 - Hydrogen.

Code of Federal Regulations, 2012 CFR

2012-07-01

... containers, pressure regulators, safety relief devices, manifolds, interconnecting piping and controls. The... against physical damage and against tampering. (d) Cabinets or housings containing hydrogen control or... valve shall be of the remote control type with no connections, flanges, or other appurtenances (other...

The JUPITER registry: 1-year results of transapical aortic valve implantation using a second-generation transcatheter heart valve in patients with aortic stenosis.

PubMed

Silaschi, Miriam; Treede, Hendrik; Rastan, Ardawan J; Baumbach, Hardy; Beyersdorf, Friedhelm; Kappert, Utz; Eichinger, Walter; Rüter, Florian; de Kroon, Thomas L; Lange, Rüdiger; Ensminger, Stephan; Wendler, Olaf

2016-11-01

Transcatheter aortic valve replacement (TAVR) is an established therapy for patients with aortic stenosis (AS) at high surgical risk. The JenaValve™ is a second-generation, self-expanding transcatheter heart valve (THV), implanted through transapical access (TA). During stent deployment, a specific 'clipping-mechanism' engages native aortic valve cusps for fixation. We present 1-year outcomes of the JUPITER registry, a post-market registry of the JenaValve for TA-TAVR. The JUPITER registry is a prospective, multicentre, uncontrolled and observational European study to evaluate the long-term safety and effectiveness of the Conformité Européenne-marked JenaValve THV. A total of 180 patients with AS were enrolled between 2012 and 2014. End-points were adjudicated in accordance with the valve academic research consortium document no. 1 definitions. The mean age was 80.4 ± 5.9 years and the mean logistic European system for cardiac operative risk evaluation I 21.2 ± 14.7%. The procedure was successful in 95.0% (171/180), implantation of a second THV (valve-in-valve) was performed in 2.2% (4/180) and conversion to surgical aortic valve replacement (SAVR) was necessary in 2.8% (5/180). No annular rupture or coronary ostia obstruction occurred. Two patients required SAVR after the day of index procedure (1.1%). All-cause mortality at 30 days was 11.1% (20/180), being cardiovascular in 7.2% (13/180). A major stroke occurred in 1.1% (2/180) at 30 days, no additional major strokes were observed during 1 year. All-cause mortality after 30 days was 13.1% (21/160) and combined efficacy at 1 year was 80.8% (122/151). At 1-year follow-up, no patient presented with more than moderate paravalvular leakage, while 2 patients (3.2%) showed moderate, 12 (19.0%) mild and 49 (82.4%) trace/none paravalvular regurgitation. In a high-risk cohort of patients undergoing TA-TAVR for AS, the use of the JenaValve THV is safe and effective. In patients at higher risk for coronary ostia obstruction, annular rupture or with limited aortic valve calcification, the JenaValve might be preferable for implantation due to its clipping-mechanism engaging native aortic valve cusps for fixation with reduced radial forces of the self-expanding stent. © The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

10 CFR 960.5-2-2 - Site ownership and control.

Code of Federal Regulations, 2010 CFR

2010-01-01

... NUCLEAR WASTE REPOSITORY Preclosure Guidelines Preclosure Radiological Safety § 960.5-2-2 Site ownership... control of access that are required in order that surface and subsurface activities during repository...

Adding a custom made pressure release valve during air enema for intussusception: A new technique.

PubMed

Ahmed, Hosni Morsi; Ahmed, Osama; Ahmed, Refaat Khodary

2015-01-01

Non-surgical reduction remains the first line treatment of choice for intussusception. The major complication of air enema reduction is bowel perforation. The authors developed a custom made pressure release valve to be added to portable insufflation devices, delivering air at pressures accepted as safe for effective reduction of intussusception in children under fluoroscopic guidance. The aim of this study was to develop a custom made pressure release valve that is suitable for the insufflation devices used for air enema reduction of intussusception and to put this valve into regular clinical practice. An adjustable, custom made pressure release valve was assembled by the authors using readily available components. The valve was coupled to a simple air enema insufflation device. The device was used for the trial of reduction of intussusception in a prospective study that included 132 patients. The success rate for air enema reduction with the new device was 88.2%. The mean pressure required to achieve complete reduction was 100 mmHg. The insufflation pressure never exceeded the preset value (120 mmHg). Of the successful cases, 58.3% were reduced from the first attempt while 36.1% required a second insufflation. Only 5.55% required a third insufflation to complete the reduction. In cases with unsuccessful pneumatic reduction attempt (18.1%), surgical treatment was required. Surgery ranged from simple reduction to resection with a primary end to end anastomosis. No complications from air enema were recorded. The authors recommend adding pressure release valves to ensure safety by avoiding pressure overshoot during the procedure.

Pars plana Ahmed valve and vitrectomy in patients with glaucoma associated with posterior segment disease.

PubMed

Wallsh, Josh O; Gallemore, Ron P; Taban, Mehran; Hu, Charles; Sharareh, Behnam

2013-01-01

To assess the safety and efficacy of a modified technique for pars plana placement of the Ahmed valve in combination with pars plana vitrectomy in the treatment of glaucoma associated with posterior segment disease. Thirty-nine eyes with glaucoma associated with posterior segment disease underwent pars plana vitrectomy combined with Ahmed valve placement. All valves were placed in the pars plana using a modified technique, without the pars plana clip, and using a scleral patch graft. The 24 eyes diagnosed with neovascular glaucoma had an improvement in intraocular pressure from 37.6 mmHg to 13.8 mmHg and best-corrected visual acuity from 2.13 logarithm of minimum angle of resolution to 1.40 logarithm of minimum angle of resolution. Fifteen eyes diagnosed with steroid-induced glaucoma had an improvement in intraocular pressure from 27.9 mmHg to 14.1 mmHg and best-corrected visual acuity from 1.38 logarithm of minimum angle of resolution to 1.13 logarithm of minimum angle of resolution. Complications included four cases of cystic bleb formation and one case of choroidal detachment and explantation for hypotony. Ahmed valve placement through the pars plana during vitrectomy is an effective option for managing complex cases of glaucoma without the use of the pars plana clip.

Ultrasound based mitral valve annulus tracking for off-pump beating heart mitral valve repair

NASA Astrophysics Data System (ADS)

Li, Feng P.; Rajchl, Martin; Moore, John; Peters, Terry M.

2014-03-01

Mitral regurgitation (MR) occurs when the mitral valve cannot close properly during systole. The NeoChordtool aims to repair MR by implanting artificial chordae tendineae on flail leaflets inside the beating heart, without a cardiopulmonary bypass. Image guidance is crucial for such a procedure due to the lack of direct vision of the targets or instruments. While this procedure is currently guided solely by transesophageal echocardiography (TEE), our previous work has demonstrated that guidance safety and efficiency can be significantly improved by employing augmented virtuality to provide virtual presentation of mitral valve annulus (MVA) and tools integrated with real time ultrasound image data. However, real-time mitral annulus tracking remains a challenge. In this paper, we describe an image-based approach to rapidly track MVA points on 2D/biplane TEE images. This approach is composed of two components: an image-based phasing component identifying images at optimal cardiac phases for tracking, and a registration component updating the coordinates of MVA points. Preliminary validation has been performed on porcine data with an average difference between manually and automatically identified MVA points of 2.5mm. Using a parallelized implementation, this approach is able to track the mitral valve at up to 10 images per second.

Fast-acting nuclear reactor control device

DOEpatents

Kotlyar, Oleg M.; West, Phillip B.

1993-01-01

A fast-acting nuclear reactor control device for moving and positioning a fety control rod to desired positions within the core of the reactor between a run position in which the safety control rod is outside the reactor core, and a shutdown position in which the rod is fully inserted in the reactor core. The device employs a hydraulic pump/motor, an electric gear motor, and solenoid valve to drive the safety control rod into the reactor core through the entire stroke of the safety control rod. An overrunning clutch allows the safety control rod to freely travel toward a safe position in the event of a partial drive system failure.

Trends and outcomes of valve surgery: 16-year results of Netherlands Cardiac Surgery National Database.

PubMed

Siregar, Sabrina; de Heer, Frederiek; Groenwold, Rolf H H; Versteegh, Michel I M; Bekkers, Jos A; Brinkman, Emile S; Bots, Michiel L; van der Graaf, Yolanda; van Herwerden, Lex A

2014-09-01

The aim was to describe procedural volumes, patient risk profile and outcomes of heart valve surgery in the past 16 years in Netherlands. The Dutch National Database for Cardio-Thoracic Surgery includes approximately 200 000 cardiac operations performed between 1995 and 2010. Information on all valve surgeries (56 397 operations) was extracted. We determined trends for changes in procedural volume, demographics, risk profile and in-hospital mortality of valve operations. Because of incomplete data in the first years of registration, the total number of operations in those years was estimated using Poisson regression. For a subset from 2007 to 2010, follow-up data were available. Survival status was obtained through linkage with the national Cause of Death Registry, and survival analysis was performed using Kaplan-Meier method. Information on discharge and readmissions was obtained from the National Hospital Discharge Registry. The annual volume of heart valve operations increased by more than 100% from an estimated 2431 in 1995 to 5906 in 2010. Adjusted for population size in Netherlands, the number of operations per 100 000 adults increased from 20 in 1995 to 43 in 2010. In 2010, frequently performed valve surgery included the following: 34.6% isolated aortic valve (AoV) replacement, 21.8% AoV replacement and coronary artery bypass grafting (CABG), 14.6% isolated mitral valve surgery (repair or replacement) and 9.1% mitral valve and CABG. In AoV surgery, an increasing use of bioprostheses in all age categories is observed. In mitral valve surgery, 75.4% was performed by repair rather than replacement in 2010. In-hospital mortality for all valve surgery decreased significantly from 4.6% in 2007 to 3.6% in 2010, whereas the mean logistic EuroSCORE remained stable (median 5.8, P = 1.000). Thirty-day mortality after all valve surgery was 3.9% and 120-day mortality was 6.5%. At 1 year, survival after all valve surgery was 91.6% and a reoperation had been performed in 1.6%. The median postoperative length of stay was 7 days (interquartile range (IQR) 5-11) in the primary hospital and 11 days (IQR 8-16), including subsequent stay, in the secondary hospital. The results of this study provide a comprehensive overview of valve surgery trends and outcomes in Netherlands. The number of heart valve operations performed in Netherlands has increased since 1995. The significant decrease in mortality and unchanged EuroSCORE between 2007 and 2010 might reflect a general improvement of the safety of valve surgery. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Drug safety data mining with a tree-based scan statistic.

PubMed

Kulldorff, Martin; Dashevsky, Inna; Avery, Taliser R; Chan, Arnold K; Davis, Robert L; Graham, David; Platt, Richard; Andrade, Susan E; Boudreau, Denise; Gunter, Margaret J; Herrinton, Lisa J; Pawloski, Pamala A; Raebel, Marsha A; Roblin, Douglas; Brown, Jeffrey S

2013-05-01

In post-marketing drug safety surveillance, data mining can potentially detect rare but serious adverse events. Assessing an entire collection of drug-event pairs is traditionally performed on a predefined level of granularity. It is unknown a priori whether a drug causes a very specific or a set of related adverse events, such as mitral valve disorders, all valve disorders, or different types of heart disease. This methodological paper evaluates the tree-based scan statistic data mining method to enhance drug safety surveillance. We use a three-million-member electronic health records database from the HMO Research Network. Using the tree-based scan statistic, we assess the safety of selected antifungal and diabetes drugs, simultaneously evaluating overlapping diagnosis groups at different granularity levels, adjusting for multiple testing. Expected and observed adverse event counts were adjusted for age, sex, and health plan, producing a log likelihood ratio test statistic. Out of 732 evaluated disease groupings, 24 were statistically significant, divided among 10 non-overlapping disease categories. Five of the 10 signals are known adverse effects, four are likely due to confounding by indication, while one may warrant further investigation. The tree-based scan statistic can be successfully applied as a data mining tool in drug safety surveillance using observational data. The total number of statistical signals was modest and does not imply a causal relationship. Rather, data mining results should be used to generate candidate drug-event pairs for rigorous epidemiological studies to evaluate the individual and comparative safety profiles of drugs. Copyright © 2013 John Wiley & Sons, Ltd.

Efficacy and safety of intravitreal bevacizumab in eyes with neovascular glaucoma undergoing Ahmed glaucoma valve implantation: 2-year follow-up.

PubMed

Arcieri, Enyr S; Paula, Jayter S; Jorge, Rodrigo; Barella, Kleyton A; Arcieri, Rafael S; Secches, Danilo J; Costa, Vital P

2015-02-01

To evaluate the efficacy and safety of intravitreal bevacizumab (IVB) in eyes with neovascular glaucoma (NVG) undergoing Ahmed glaucoma valve (AGV) implantation. This was a multicentre, prospective, randomized clinical trial that enrolled 40 patients with uncontrolled neovascular glaucoma that had undergone panretinal photocoagulation and required glaucoma drainage device implantation. Patients were randomized to receive IVB (1.25 mg) or not during Ahmed valve implant surgery. Injections were administered intra-operatively, and 4 and 8 weeks after surgery. After a mean follow-up of 2.25 ± 0.67 years (range 1.5-3 years), both groups showed a significant decrease in IOP (p < 0.05). There was no difference in IOP between groups except at the 18-month interval, when IOP in IVB group was significantly lower (14.57 ± 1.72 mmHg vs. 18.37 ± 1.06 mmHg - p = 0.0002). There was no difference in survival success rates between groups. At 24 months, there was a trend to patients treated with IVB using less antiglaucoma medications than the control group (p = 0.0648). Complete regression of rubeosis iridis was significantly more frequent in the IVB group (80%) than in the control group (25%) (p = 0.0015). Intravitreal bevacizumab may lead to regression of new vessels both in the iris and in the anterior chamber angle in patients with neovascular glaucoma undergoing Ahmed glaucoma valve implantation. There is a trend to slightly lower IOPs and number of medications with IVB use during AGV implantation for neovascular glaucoma. © 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Biocompatibility and Systemic Safety of a Novel Implantable Annuloplasty Ring for the Treatment of Mitral Regurgitation in a Minipig Model.

PubMed

Ramot, Yuval; Rousselle, Serge D; Yellin, Nadav; Willenz, Udi; Sabag, Itai; Avner, Avi; Nyska, Abraham

2016-07-01

Prosthetic annuloplasty rings are a common treatment modality for mitral regurgitation, and recently, percutaneous implantation techniques have gained popularity due to their favorable safety profile. Although in common use, biocompatibility of annuloplasty rings has been reported only sparsely in the literature, and none of these reports used the percutaneous technique of implantation. We report on the biocompatibility and the systemic safety of a novel transcatheter mitral valve annuloplasty ring (AMEND™) in 6 minipigs. This device is composed of a nitinol tube surrounded by a braided polyethylene terephthalate fabric tube. The device produced no adverse inflammatory response, showing gradual integration between the metal ring and the fabric by normal host fibrocellular response, leading to complete neoendocardium coverage. There was no evidence for adverse reactions, rejection, or intolerance in the valvular structure. In 2 animals, hemopericardium resulted from the implantation procedure, leading to right-sided cardiac insufficiency with pulmonary edema and liver congestion. The findings reported herein can serve as a case study for the expected healing pathology reactions after implantation of transcatheter mitral valve annuloplasty rings. © The Author(s) 2016.

Poland since Martial Law

DTIC Science & Technology

1988-12-01

medical services, professional mobility , job security, and education. These were among the "human rights" on which the socialist system was said to be...economic reform is to mean anything, job uncertainty will supersede full employment. Professional mobility , once an important safety valve against worker

Comparative study of the safety and efficacy of the Ahmed glaucoma valve model M4 (high density porous polyethylene) and the model S2 (polypropylene) in patients with neovascular glaucoma.

PubMed

Gil-Carrasco, F; Jiménez-Román, J; Turati-Acosta, M; Bello-López Portillo, H; Isida-Llerandi, C G

2016-09-01

To prospectively evaluate the safety and efficacy of the Ahmed glaucoma valve model M4 (High density porous polyethylene plate; Medpor) compared with the model S2 (polypropylene plate). Mexican patients with neovascular glaucoma were randomly included for each group (M4 and S2). They were operated on using conventional techniques and creating a sub-episcleral tunnel to place the valve tube in the anterior chamber. After one year of follow-up, the results were evaluated with respect to a post-operative reduction in pressure, changes in visual acuity, the need for drugs, and complications, as well as the demographic characteristics of each group. Each operation using the M4 valve was performed by a single surgeon (FGC). Those operated on using the S2 model had their surgery performed by the staff surgeons at the Glaucoma Department of the Mexican Association to Prevent Blindness (APEC). Each group (M4 and S2) contained 21 eyes of 21 Mexican patients with a diagnosis of neovascular glaucoma, leading to a total of 42 patients undergoing surgery. The mean preoperative intraocular pressure (IOP) was 43.5 (±11.8), and 42.24 (±12.84) mmHg for the M4 and S2 groups, respectively. After one year of follow-up, the IOP reported was 18.9 (±9.7) mmHg for the final 18 patients in the M4 group, and 16.38 (±9.76) mmHg for the 21 patients in the S2 group. The design of a drainage valve device such as that of Ahmed has characteristics such as moderate control of IOP, thanks to the valve component in the immediate post-operative period, which makes them safer than other non-valve devices. This avoids an excess of flat chambers and the presence of low IOPs, which can lead to bleeding in the early post-operative period due to the weak desmosomal junctions of the newly formed vessels, with the advantage of maintaining suitable control of IOP from the first day after surgery. Further studies with longer follow-up with a larger number of patients are needed to evaluate the effectiveness of this porous coating in the control of neovascular glaucoma. Copyright © 2016 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

The WISDOM Radar: Unveiling the Subsurface Beneath the ExoMars Rover and Identifying the Best Locations for Drilling

PubMed Central

Clifford, Stephen; Plettemeier, Dirk; Le Gall, Alice; Hervé, Yann; Dorizon, Sophie; Quantin-Nataf, Cathy; Benedix, Wolf-Stefan; Schwenzer, Susanne; Pettinelli, Elena; Heggy, Essam; Herique, Alain; Berthelier, Jean-Jacques; Kofman, Wlodek; Vago, Jorge L.; Hamran, Svein-Erik

2017-01-01

Abstract The search for evidence of past or present life on Mars is the principal objective of the 2020 ESA-Roscosmos ExoMars Rover mission. If such evidence is to be found anywhere, it will most likely be in the subsurface, where organic molecules are shielded from the destructive effects of ionizing radiation and atmospheric oxidants. For this reason, the ExoMars Rover mission has been optimized to investigate the subsurface to identify, understand, and sample those locations where conditions for the preservation of evidence of past life are most likely to be found. The Water Ice Subsurface Deposit Observation on Mars (WISDOM) ground-penetrating radar has been designed to provide information about the nature of the shallow subsurface over depth ranging from 3 to 10 m (with a vertical resolution of up to 3 cm), depending on the dielectric properties of the regolith. This depth range is critical to understanding the geologic evolution stratigraphy and distribution and state of subsurface H2O, which provide important clues in the search for life and the identification of optimal drilling sites for investigation and sampling by the Rover's 2-m drill. WISDOM will help ensure the safety and success of drilling operations by identification of potential hazards that might interfere with retrieval of subsurface samples. Key Words: Ground penetrating radar—Martian shallow subsurface—ExoMars. Astrobiology 17, 565–584.

Safety and efficacy of percutaneous balloon mitral valvotomy in severe mitral stenosis with moderate mitral regurgitation - A prospective study.

PubMed

Desabandhu, Vinayakumar; Peringadan, Nithin Gopalan; Krishnan, Mangalath Narayanan

Percutaneous balloon mitral valvotomy (PBMV) is generally considered as a contraindication in patients with mitral stenosis (MS) associated with moderate to severe mitral regurgitation (MR). We sought to compare the safety and efficacy of PBMV in patients with severe MS and with moderate MR with those with less than moderate or no MR. Symptomatic patients of MS with mitral valve area ≤1.5cm 2 were screened into two groups: Group I with moderate MR and Group II with less than moderate or no MR. Clinical and echocardiographic assessments were done at 24h, 1 month, and 6 months post-procedure. A treadmill testing was done prior to PBMV and at 6 months. Primary safety outcome was a composite of cardiovascular death and development of severe MR with or without requirement for mitral valve replacement at 30 days of procedure. Efficacy of the procedure was measured as improvement in functional class, treadmill time, and mitral valve area (MVA) at 6 months. Seventeen patients with moderate MR and 208 patients with less than moderate MR underwent PBMV. Primary outcome showed no significant difference [2 (11.7%) in Group I vs. 8 (3.85%) in Group II, p=0.36]; occurrence of severe MR was higher in Group I [RR=4.87, 95% C.I.=1.42-16.69]. In Group I patients, improvement in treadmill time was seen in 12 (70.59%), functional class in 13 (76.47%), and MVA in all patients. In patients having severe MS associated with moderate MR, PBMV may be a safe option and provides sustained symptomatic benefit. Copyright © 2016 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

Low permanent pacemaker rates following Lotus device implantation for transcatheter aortic valve replacement due to modified implantation protocol.

PubMed

Krackhardt, Florian; Kherad, Behrouz; Krisper, Maximilian; Pieske, Burkert; Laule, Michael; Tschöpe, Carsten

2017-01-01

Conduction disturbances requiring permanent pacemaker implantation following transcatheter aortic valve replacement (TAVR) are a common problem. Pacemaker implantation rates after TAVR appear to be higher compared to conventional aortic valve replacement. The aim of this study was to analyze whether a high annulus implantation conveys the benefit of a decreased rate of permanent pacemaker implantation while being safe and successful according to Valve Academic Research Consortium 2 (VARC2)-criteria. A total of 23 patients with symptomatic severe aortic valve stenosis, an aortic annulus of 19-27 mm and at high risk for surgery were treated with the Lotus valve. In all patients the valve was implanted in a high annulus position via femoral access. The primary device performance endpoint was VARC2-defined device success after 30 days and the primary safety endpoint was the need for permanent pacemaker implantation. The mean age was 73.23 ± 7.65 years, 46% were female, 38% were New York Heart Association class III/IV at baseline. Thirty-day follow-up data were available for all patients. The VARC2-defined device success rate after 30 days was 22/23 (96%). 2/21 (10%) patients required a newly implanted pacemaker due to 3rd degree atrioventricular block. 25% of the patients developed a new left bundle branch block after valvuloplasty or device implantation. 21 of the 23 patients (96%) had no other signs of conduction disturbances after 30 days. The approach of the modified implantation technique of Lotus TAVR device was safe and effective. The incidence of need for a permanent pacemaker following TAVR could be significantly reduced due to adopted implantation protocol.

Pressure Relief Devices

NASA Astrophysics Data System (ADS)

Manha, William D.

2010-09-01

Pressure relief devices are used in pressure systems and on pressure vessels to prevent catastrophic rupture or explosion from excessive pressure. Pressure systems and pressure vessels have manufacturers maximum rated operating pressures or maximum design pressures(MDP) for which there are relatively high safety factors and minimum risk of rupture or explosion. Pressure systems and pressure vessels that have a potential to exceed the MDP by being connected to another higher pressure source, a compressor, or heat to water(boiler) are required to have over-pressure protecting devices. Such devices can be relief valves and/or burst discs to safely relieve potentially excessive pressure and prevent unacceptable ruptures and explosions which result in fail-safe pressure systems and pressure vessels. Common aerospace relief valve and burst disc requirements and standards will be presented. This will include the NASA PSRP Interpretation Letter TA-88-074 Fault Tolerance of Systems Using Specially Certified Burst Disks that dictates burst disc requirements for payloads on Shuttle. Two recent undesirable manned space payloads pressure relief devices and practices will be discussed, as well as why these practices should not be continued. One example for discussion is the use of three burst discs that have been placed in series to comply with safety requirements of three controls to prevent a catastrophic hazard of the over-pressurization and rupture of pressure system and/or vessels. The cavities between the burst discs are evacuated and are the reference pressures for activating the two upstream burst discs. If the upstream burst disc leaks into the reference cavity, the reference pressure increases and it can increase the burst disc activating pressure and potentially result in the burst disc assembly being ineffective for over pressure protection. The three burst discs-in-series assembly was found acceptable because the burst discs are designed for minimum risk(DFMR) of leakage into the reference cavity. Since the burst discs are DFMR, a single burst disc would suffice, without adding the two leak-into-reference cavity failure modes. A single DFMR burst disc is preferable. An Alpha Magnetic Spectrometer - 02 burst disc assembly, with three-in-series burst discs test failure, necessitated the deletion of one of the burst discs, will be presented. Payload relief valves require periodic retests were extended significantly beyond the normal one year retest period because of the reduced ISS down mass capability which followed the Columbia accident. The acceptability of the extended retest period was determined by analysis, materials stability, benign environment, relatively inert fluid exposure, etc.(The policy letter, NC4-02-205 Guidelines for Certification and Verification of Pressure System Control Hardware, that permitted this action will be provided even though this application is not recommended for extending relief valve annual retest requirements.) The first crack pressure of a relief valve after an extended inactive period can be higher than the set crack pressure. Extrapolation of the extended inactive period and increased crack pressure could result in ineffective over pressure protection. Thus, relief valves with a ring or lever for activation are recommended so the relief valve can periodically be verified to open, functionality verified and the extended relief valve retest period should be discouraged. Stainless Steel cylindrical poppet-in-cylindrical housing check valves should never be used in a fluid with ions for an extended period of time, because the poppet is vulnerable to seizing or not functioning as a relief valve, even though the specifications, crack pressure, reseat pressure, maximum flow, and reseat leak look very much like the specifications for a relief valve. The technical reasons for this avoidance of using check valves as a relief valve will be discussed. The presentation will be summarized and recommendations made.

Design Criteria for Aggregate-Surfaced Roads and Airfields

DTIC Science & Technology

1989-04-01

functional failure conditions and their effects are tabulated in Table 4. It indicates that many distress factors may act on the gravel surface to increase...displacements. Table 4 Major Distress Types of Low-Volume Roads Distress Factor Effect on ..... Dusting Safety, environment Surface looseness Safety, roughness...will be less than that assumed as the design objective. Frost Considerations 9. The detrimental effects of frost action in subsurface materials of

Printing Our Way to Safety: Applications of 3-D Printing in Lockout/Tagout

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, Phil; Bender, Guido

2016-12-01

This article describes how a team at the National Renewable Energy Laboratory used 3-D printing to manufacture custom lockout/tagout devices to isolate valves that were clustered too tightly to allow for generic lockout/tagout devices to be used.

49 CFR 230.48 - Number and capacity.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Number and capacity. 230.48 Section 230.48 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Safety Relief Valves § 230.48 Number and capacity. (a) Number and capacity. Every boiler shall be...

Flavodiiron proteins act as safety valve for electrons in Physcomitrella patens.

PubMed

Gerotto, Caterina; Alboresi, Alessandro; Meneghesso, Andrea; Jokel, Martina; Suorsa, Marjaana; Aro, Eva-Mari; Morosinotto, Tomas

2016-10-25

Photosynthetic organisms support cell metabolism by harvesting sunlight to fuel the photosynthetic electron transport. The flow of excitation energy and electrons in the photosynthetic apparatus needs to be continuously modulated to respond to dynamics of environmental conditions, and Flavodiiron (FLV) proteins are seminal components of this regulatory machinery in cyanobacteria. FLVs were lost during evolution by flowering plants, but are still present in nonvascular plants such as Physcomitrella patens We generated P. patens mutants depleted in FLV proteins, showing their function as an electron sink downstream of photosystem I for the first seconds after a change in light intensity. flv knock-out plants showed impaired growth and photosystem I photoinhibition when exposed to fluctuating light, demonstrating FLV's biological role as a safety valve from excess electrons on illumination changes. The lack of FLVs was partially compensated for by an increased cyclic electron transport, suggesting that in flowering plants, the FLV's role was taken by other alternative electron routes.

Flavodiiron proteins act as safety valve for electrons in Physcomitrella patens

PubMed Central

Gerotto, Caterina; Meneghesso, Andrea; Jokel, Martina; Suorsa, Marjaana; Aro, Eva-Mari

2016-01-01

Photosynthetic organisms support cell metabolism by harvesting sunlight to fuel the photosynthetic electron transport. The flow of excitation energy and electrons in the photosynthetic apparatus needs to be continuously modulated to respond to dynamics of environmental conditions, and Flavodiiron (FLV) proteins are seminal components of this regulatory machinery in cyanobacteria. FLVs were lost during evolution by flowering plants, but are still present in nonvascular plants such as Physcomitrella patens. We generated P. patens mutants depleted in FLV proteins, showing their function as an electron sink downstream of photosystem I for the first seconds after a change in light intensity. flv knock-out plants showed impaired growth and photosystem I photoinhibition when exposed to fluctuating light, demonstrating FLV’s biological role as a safety valve from excess electrons on illumination changes. The lack of FLVs was partially compensated for by an increased cyclic electron transport, suggesting that in flowering plants, the FLV’s role was taken by other alternative electron routes. PMID:27791022

Minutes of the 23rd Eplosives Safety Seminar, volume 2

NASA Astrophysics Data System (ADS)

1988-08-01

Some areas of discussion at this seminar were: Hazards and risks of the disposal of chemical munitions using a cryogenic process; Special equipment for demilitarization of lethal chemical agent filled munitions; explosive containment room (ECR) repair Johnston Atoll chemical agent disposal system; Sympathetic detonation testing; Blast loads, external and internal; Structural reponse testing of walls, doors, and valves; Underground explosion effects, external airblast; Explosives shipping, transportation safety and port licensing; Explosive safety management; Underground explosion effects, model test and soil rock effects; Chemical risk and protection of workers; and Full scale explosives storage test.

[Lessons from a heart valve prosthesis controversy].

PubMed

Vandenbroucke, J P; Grobbee, D E

1998-07-18

Two lessons are to be learnt from the Björk-Shiley heart valve prosthesis tragedy. In the first place pharmacoepidemiologic studies are seriously hampered by recent privacy legislation. Individual patients carrying such a prosthesis cannot be traced and advised as to their health risks any more, because their legal autonomy has to be respected. This is clearly not to their advantage. In the second place the atmosphere of marketing and litigation and the increasing dependency of researchers on money from sources with conflicting interests is not conducive to a well-informed and balanced judgement of the epidemiological evidence of safety and efficacy of medical treatments.

Quality and Safety in Health Care, Part XXXII: Additional Outcome Predictors for Transcatheter Aortic Valve Replacement.

PubMed

Harolds, Jay A

2018-02-01

Mortality 12 months after a transcatheter aortic valve replacement (TAVR) is partly due to a number of reasons in addition to the usual preprocedural medical patient risk factors. In patients who need a permanent pacemaker placed after the procedure, the mortality risk goes up. The death rate following a TAVR varies considerably at different institutions, and the past death rate of TAVR patients at an institution is predictive of the mortality rate of new patients having this procedure. In addition, the quality of life of the individual before the procedure is predictive of the 12-month mortality outcome after the TAVR is done.

Note: Hollow cathode lamp with integral, high optical efficiency isolation valve: a modular vacuum ultraviolet source.

PubMed

Roberts, F Sloan; Anderson, Scott L

2013-12-01

The design and operating conditions of a hollow cathode discharge lamp for the generation of vacuum ultraviolet radiation, suitable for ultrahigh vacuum (UHV) application, are described in detail. The design is easily constructed, and modular, allowing it to be adapted to different experimental requirements. A thin isolation valve is built into one of the differential pumping stages, isolating the discharge section from the UHV section, both for vacuum safety and to allow lamp maintenance without venting the UHV chamber. The lamp has been used both for ultraviolet photoelectron spectroscopy of surfaces and as a "soft" photoionization source for gas-phase mass spectrometry.

Modeling of Near-Surface Leakage and Seepage of CO2 for Risk Characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oldenburg, Curtis M.; Unger, Andre A.J.

2004-02-18

The injection of carbon dioxide (CO2) into deep geologic carbon sequestration sites entails risk that CO2 will leak away from the primary storage formation and migrate upwards to the unsaturated zone from which it can seep out of the ground. We have developed a coupled modeling framework called T2CA for simulating CO2 leakage and seepage in the subsurface and in the atmospheric surface layer. The results of model simulations can be used to calculate the two key health, safety, and environmental (HSE) risk drivers, namely CO2 seepage flux and nearsurface CO2 concentrations. Sensitivity studies for a subsurface system with amore » thick unsaturated zone show limited leakage attenuation resulting in correspondingly large CO2 concentrations in the shallow subsurface. Large CO2 concentrations in the shallow subsurface present a risk to plant and tree roots, and to humans and other animals in subsurface structures such as basements or utility vaults. Whereas CO2 concentrations in the subsurface can be high, surfacelayer winds reduce CO2 concentrations to low levels for the fluxes investigated. We recommend more verification and case studies be carried out with T2CA, along with the development of extensions to handle additional scenarios such as calm conditions, topographic effects, and catastrophic surface-layer discharge events.« less

Percutaneous pulmonary valve implantation for free pulmonary regurgitation following conduit-free surgery of the right ventricular outflow tract.

PubMed

Cools, Bjorn; Brown, Stephen C; Heying, Ruth; Jansen, Katrijn; Boshoff, Derize E; Budts, Werner; Gewillig, Marc

2015-01-01

Pulmonary regurgitation (PR) following surgery of the right ventricular outflow tract (RVOT) is not innocent and leads to significant right heart dysfunction over time. Recent studies have demonstrated that percutaneous valves can be implanted in conduit free outflow tracts with good outcomes. To evaluate in patients with severe PR--anticipated to require future pulmonary valve replacement--the feasibility and safety of pre-stenting dilated non-stenotic patched conduit-free right ventricular outflow tracts before excessive dilation occurs, followed by percutaneous pulmonary valve implantation (PPVI). Twenty seven patients were evaluated, but only 23 were deemed suitable based on the presence of an adequate retention zone ≤ 24 mm defined by semi-compliant balloon interrogation of the RVOT. A 2 step procedure was performed: first the landing zone was prepared by deploying a bare stent, followed 2 months later by valve implantation. RVOT pre-stenting with an open cell bare metal stent (Andrastent XXL range) was performed at a median age of 13.0 years (range: 6.0-44.9) with a median weight of 44.3 kg (range: 20.0-88.0). Ninety six percent (22/23) of patients proceeded to PPVI a median of 2.4 months (range: 1.4-3.4) after initial pre-stent placement. Twenty one Melody valves and one 26 mm Edwards SAPIEN™ valve were implanted. Complications consisted of embolization of prestent (n = 1), scrunching (n = 4) and mild stent dislocation (n = 2). During follow-up, no stent fractures were observed and right ventricular dimensions decreased significantly. Post-surgical conduit-free non-stenotic RVOT with free pulmonary regurgitation can be treated percutaneously with a valved stent if anatomical (predominantly size) criteria are met. In experienced hands, the technique is feasible with low morbidity. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

46 CFR 151.50-30 - Compressed gases.

Code of Federal Regulations, 2011 CFR

2011-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-30 Compressed gases. (a) All tank inlet and outlet connections, except safety relief valves, liquid level gauging devices, and pressure gauges shall be marked to designate whether they terminate in the vapor or liquid space. Labels, when...

46 CFR 151.50-30 - Compressed gases.

Code of Federal Regulations, 2014 CFR

2014-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-30 Compressed gases. (a) All tank inlet and outlet connections, except safety relief valves, liquid level gauging devices, and pressure gauges shall be marked to designate whether they terminate in the vapor or liquid space. Labels, when...

46 CFR 151.50-30 - Compressed gases.

Code of Federal Regulations, 2012 CFR

2012-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-30 Compressed gases. (a) All tank inlet and outlet connections, except safety relief valves, liquid level gauging devices, and pressure gauges shall be marked to designate whether they terminate in the vapor or liquid space. Labels, when...

46 CFR 151.50-30 - Compressed gases.

Code of Federal Regulations, 2013 CFR

2013-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-30 Compressed gases. (a) All tank inlet and outlet connections, except safety relief valves, liquid level gauging devices, and pressure gauges shall be marked to designate whether they terminate in the vapor or liquid space. Labels, when...

46 CFR 151.50-30 - Compressed gases.

Code of Federal Regulations, 2010 CFR

2010-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-30 Compressed gases. (a) All tank inlet and outlet connections, except safety relief valves, liquid level gauging devices, and pressure gauges shall be marked to designate whether they terminate in the vapor or liquid space. Labels, when...

46 CFR 162.018-1 - Applicable specifications, and referenced material.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) The ASME Code may be obtained from the American Society of Mechanical Engineers, United Engineering..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied... (Procedures Applicable to the Public) and Subpart 50.15 of Subchapter F (Marine Engineering) of this chapter...

46 CFR 162.018-1 - Applicable specifications, and referenced material.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) The ASME Code may be obtained from the American Society of Mechanical Engineers, United Engineering..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied... (Procedures Applicable to the Public) and Subpart 50.15 of Subchapter F (Marine Engineering) of this chapter...

46 CFR 162.018-1 - Applicable specifications, and referenced material.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) The ASME Code may be obtained from the American Society of Mechanical Engineers, United Engineering..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied... (Procedures Applicable to the Public) and Subpart 50.15 of Subchapter F (Marine Engineering) of this chapter...

46 CFR 162.018-1 - Applicable specifications, and referenced material.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) The ASME Code may be obtained from the American Society of Mechanical Engineers, United Engineering..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied... (Procedures Applicable to the Public) and Subpart 50.15 of Subchapter F (Marine Engineering) of this chapter...

46 CFR 162.018-1 - Applicable specifications, and referenced material.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) The ASME Code may be obtained from the American Society of Mechanical Engineers, United Engineering..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Safety Relief Valves, Liquefied... (Procedures Applicable to the Public) and Subpart 50.15 of Subchapter F (Marine Engineering) of this chapter...

Evaluation of symptoms and patients' comfort for JJ-ureteral stents with and without antireflux-membrane valve.

PubMed

Ecke, Thorsten H; Bartel, Peter; Hallmann, Steffen; Ruttloff, Jürgen

2010-01-01

To evaluate safety and patients' comfort by using the ureteral stent symptom questionnaire. Ureteral stents are used to provide upper urinary-tract drainage. A total of 133 JJ-ureteral stents with and without antireflux-membrane valve as consecutive referrals for therapy of hydronephrosis have been inserted. Four weeks after insertion of the ureteral stent, the patients were asked about pain while urination, flank pain due to reflux, and the comparison with former stents. Ultrasound of the kidney for hydronephrosis grade and creatinine value as follow-up have been documented. Statistical analysis included chi(2) test after Pearson correlation computed and performed by SPSS software. We found a high correlation between the JJ-ureteral stent used and the detection of a hydronephrosis (P = .004). More patients who had a JJ-ureteral stent without valve complained of flank pain (P <.0005) and pain in the bladder (P <.0005). Patients who had a ureteral stent before were asked to compare new stents with the former ones. No patients with a JJ-ureteral stent with valve found this one to be worse than what they had before. JJ-stent related symptoms are a major problem for these patients. New stent designs and materials will be developed in the future to reduce stent-related morbidity and improve patient comfort. JJ-ureteral stents with an antireflux-membrane valve have a lower complication rate and provide a higher patient comfort compared with stents without valve. Crown Copyright 2010. Published by Elsevier Inc. All rights reserved.

Discontinuous atmospheric pressure interface for mass spectrometry using a solenoid pulse valve.

PubMed

Usmanov, Dilshadbek T; Hiraoka, Kenzo

2016-08-30

For the development of on-site mass spectrometry for security and safety, point-of-care analysis, etc., the gas volume introduced into the vacuum should be reduced to a minimum. To cope with this demand, a discontinuous atmospheric pressure interface using a solenoid pulse valve was developed. The sample gas was introduced discontinuously into the ionization cell with a volume of 0.17 cm(3) . The sampled gas in the cell was ionized by an alternating current (ac) corona discharge. The generated ions were sampled through a 0.25 mm i.d. and 12 mm long nickel capillary into the vacuum of a time-of-flight mass spectrometer. A gas flow rate of ~25 mL/min was achieved with the 1 Hz pulse valve operation and 20 ms valve opening time. Sub-ng limits of detection for less volatile compounds such as explosives and drugs were obtained. Due to its compact size and low gas load to the vacuum, this new interface may be useful for applications in miniaturized mass spectrometry. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Method for control of subsurface coal gasification

DOEpatents

Komar, Charles A.

1976-12-14

The burn front in an in situ underground coal gasification operation is controlled by utilizing at least two parallel groups of vertical bore holes disposed in the coalbed at spaced-apart locations in planes orthogonal to the plane of maximum permeability in the coalbed. The combustion of the coal is initiated in the coalbed adjacent to one group of the bore holes to establish a combustion zone extending across the group while the pressure of the combustion supporting gas mixture and/or the combustion products is regulated at each well head by valving to control the burn rate and maintain a uniform propagation of the burn front between the spaced-apart hole groups to gasify virtually all the coal lying therebetween.

Annual Report to Congress - Fiscal Year 2000, from the Strategic Environmental Research and Development Program

DTIC Science & Technology

2001-03-01

perchlorate bioremediation systems. The objective of this project is to identify the key environmental factors in subsurface environments that inhibit... environment . For the Health and Safety for Innovative Environmental Technologies subthrust, DoD is working to improve the health and safety of workers and...dilution of pollutants. Similarly, other relevant environments range from humid , forested landscapes to high, arid mountainous domains. In addition, DoD

Monitoring, safety systems for LNG and LPG operators

DOE Office of Scientific and Technical Information (OSTI.GOV)

True, W.R.

Operators in Korea and Australia have chosen monitoring and control systems in recent contracts for LNG and LPG storage. Korea Gas Corp. (Kogas) has hired Whessoe Varec, Calais, to provide monitoring systems for four LNG storage tanks being built at Kogas` Inchon terminal. For Elgas Ltd., Port Botany, Australia, Whessoe Varec has already shipped a safety valve-shutdown system to a new LPG cavern-storage facility under construction. The paper describes the systems, terminal monitoring, dynamic approach to tank management, and meeting the growing demand for LPG.

77 FR 53202 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

... efficacy of the TAVR technologies for the treatment of aortic stenosis. The data will also include the... surveillance of the quality, safety and efficacy of new medical devices to treat aortic stenosis. For purposes... Determination (NCD) entitled, ``Transcatheter Aortic Valve Replacement (TAVR)''. The TAVR device is only covered...

49 CFR 179.103-3 - Venting, loading and unloading valves, measuring and sampling devices.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109... not less than one-fourth inch in thickness. (c) When tank car is used to transport liquefied flammable...

49 CFR 179.103-3 - Venting, loading and unloading valves, measuring and sampling devices.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109... not less than one-fourth inch in thickness. (c) When tank car is used to transport liquefied flammable...

49 CFR 179.103-3 - Venting, loading and unloading valves, measuring and sampling devices.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT... not less than one-fourth inch in thickness. (c) When tank car is used to transport liquefied flammable...

49 CFR 179.103-3 - Venting, loading and unloading valves, measuring and sampling devices.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109... not less than one-fourth inch in thickness. (c) When tank car is used to transport liquefied flammable...

46 CFR 154.1130 - Sections.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Sections. 154.1130 Section 154.1130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS FOR SELF... spray system is divided into sections, the control valves must be at a single manifold that is aft of...

46 CFR 154.1130 - Sections.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Sections. 154.1130 Section 154.1130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS FOR SELF... spray system is divided into sections, the control valves must be at a single manifold that is aft of...

46 CFR 56.50-1 - General (replaces 122).

Code of Federal Regulations, 2011 CFR

2011-10-01

... maintenance of machinery and appurtenances. The joints shall be located so that adequate space is provided for... Safety Center. All power actuated valves required in an emergency to operate the vessel's machinery, to... liquids, except that tank barges having plug cocks inside cargo tanks may have reach rods of extra-heavy...

30 CFR 56.13021 - High-pressure hose connections.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-pressure hose connections. 56.13021... and Boilers § 56.13021 High-pressure hose connections. Except where automatic shutoff valves are used, safety chains or other suitable locking devices shall be used at connections to machines of high-pressure...

Assessment of the Technology and Practice for Determining Casing Degradation during Offshore Drilling Operations.

DTIC Science & Technology

1982-09-01

industries. Transport of hydrocarbons Castagnet. A.COG. InStituto de Energia Atomica. Sao Paulo (Brazil). Divisao de ApI icacao de Radioisotopos na...DETECTOR*; MEETING PAPER; OPERATING CONDITION; PIPELINE*; PRESSURE: SAFETY EQUIPMENT; SOLAR ENERGY: THERMAL INSULATION: TUBE; VALVE Leaks In gas grids

40 CFR 1700.5 - Discharges not requiring control.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Blowdown: the water and steam discharged when a steam boiler is blown down, or when a steam safety valve is tested. (b) Catapult Wet Accumulator Discharge: the water discharged from a catapult wet accumulator, which stores a steam/water mixture for launching aircraft from an aircraft carrier. (c) Cathodic...

40 CFR 1700.5 - Discharges not requiring control.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Blowdown: the water and steam discharged when a steam boiler is blown down, or when a steam safety valve is tested. (b) Catapult Wet Accumulator Discharge: the water discharged from a catapult wet accumulator, which stores a steam/water mixture for launching aircraft from an aircraft carrier. (c) Cathodic...

40 CFR 1700.5 - Discharges not requiring control.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Blowdown: the water and steam discharged when a steam boiler is blown down, or when a steam safety valve is tested. (b) Catapult Wet Accumulator Discharge: the water discharged from a catapult wet accumulator, which stores a steam/water mixture for launching aircraft from an aircraft carrier. (c) Cathodic...

40 CFR 1700.5 - Discharges not requiring control.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Blowdown: the water and steam discharged when a steam boiler is blown down, or when a steam safety valve is tested. (b) Catapult Wet Accumulator Discharge: the water discharged from a catapult wet accumulator, which stores a steam/water mixture for launching aircraft from an aircraft carrier. (c) Cathodic...

40 CFR 1700.5 - Discharges not requiring control.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Blowdown: the water and steam discharged when a steam boiler is blown down, or when a steam safety valve is tested. (b) Catapult Wet Accumulator Discharge: the water discharged from a catapult wet accumulator, which stores a steam/water mixture for launching aircraft from an aircraft carrier. (c) Cathodic...

49 CFR 192.150 - Passage of internal inspection devices.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) of this section, each new transmission line and each replacement of line pipe, valve, fitting, or other line component in a transmission line must be designed and constructed to accommodate the passage... TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline...

49 CFR 192.150 - Passage of internal inspection devices.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) of this section, each new transmission line and each replacement of line pipe, valve, fitting, or other line component in a transmission line must be designed and constructed to accommodate the passage... TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline...

49 CFR 192.150 - Passage of internal inspection devices.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) of this section, each new transmission line and each replacement of line pipe, valve, fitting, or other line component in a transmission line must be designed and constructed to accommodate the passage... TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline...

49 CFR 192.150 - Passage of internal inspection devices.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) of this section, each new transmission line and each replacement of line pipe, valve, fitting, or other line component in a transmission line must be designed and constructed to accommodate the passage... TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline...

Sub Surface Geoelectrical Imaging for Potential Geohazard in Infrastructure Construction in Sidoarjo, East Java

NASA Astrophysics Data System (ADS)

Sumintadireja, Prihadi; Irawan, Diky

2017-06-01

Mud volcano remnants are identified in Surabaya and adjacent areas. The people in East Java based on historical report are custom and able to adjust with the natural phenomena within their areas. Sidoarjo mud volcano phenomena which coincident with drilling activity in 29 May 2006 is making people and government anxious for development a new infrastructure such as high rise building, toll road etc. An understanding of a geological hazard which can be single, sequential or combined events in their origin is the main key importance in subsurface imaging. Geological hazard can be identified by geophysical, geological, geotechnical method. The prompt selection of geophysical method to reveal subsurface condition is very important factor instead of survey design and field data acquisition. Revealing subsurface condition is very important information for site investigation consists of geological, geophysical and geotechnical data, whereas data analysis will help civil engineer design and calculate the construction safety.

A Review of the Ahmed Glaucoma Valve Implant and Comparison with Other Surgical Operations.

PubMed

Riva, Ivano; Roberti, Gloria; Katsanos, Andreas; Oddone, Francesco; Quaranta, Luciano

2017-04-01

The Ahmed glaucoma valve (AGV) is a popular glaucoma drainage implant used for the control of intraocular pressure in patients with glaucoma. While in the past AGV implantation was reserved for glaucoma patients poorly controlled after one or more filtration procedures, mounting evidence has recently encouraged its use as a primary surgery in selected cases. AGV has been demonstrated to be safe and effective in reducing intraocular pressure in patients with primary or secondary refractory glaucoma. Compared to other glaucoma surgeries, AGV implantation has shown favorable efficacy and safety. The aim of this article is to review the results of studies directly comparing AGV with other surgical procedures in patients with glaucoma.

Note: Hollow cathode lamp with integral, high optical efficiency isolation valve: A modular vacuum ultraviolet source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sloan Roberts, F.; Anderson, Scott L.

2013-12-15

The design and operating conditions of a hollow cathode discharge lamp for the generation of vacuum ultraviolet radiation, suitable for ultrahigh vacuum (UHV) application, are described in detail. The design is easily constructed, and modular, allowing it to be adapted to different experimental requirements. A thin isolation valve is built into one of the differential pumping stages, isolating the discharge section from the UHV section, both for vacuum safety and to allow lamp maintenance without venting the UHV chamber. The lamp has been used both for ultraviolet photoelectron spectroscopy of surfaces and as a “soft” photoionization source for gas-phase massmore » spectrometry.« less

Numerical Model of Full Cardiac Cycle Hemodynamics in a Total Artificial Heart and the Effect of Its Size on Platelet Activation

PubMed Central

Marom, Gil; Chiu, Wei-Che; Crosby, Jessica R.; DeCook, Katrina J.; Prabhakar, Saurabh; Horner, Marc; Slepian, Marvin J.; Bluestein, Danny

2014-01-01

The SynCardia total artificial heart (TAH) is the only FDA approved device for replacing hearts in patients with congestive heart failure. It pumps blood via pneumatically driven diaphragms and controls the flow with mechanical valves. While it has been successfully implanted in more than 1,300 patients, its size precludes implantation in smaller patients. This study’s aim was to evaluate the viability of scaled-down TAHs by quantifying thrombogenic potentials from flow patterns. Simulations of systole were first conducted with stationary valves, followed by an advanced full-cardiac-cycle model with moving valves. All the models included deforming diaphragms and platelet suspension in the blood flow. Flow stress-accumulations were computed for the platelet trajectories and thrombogenic potentials were assessed. The simulations successfully captured complex flow patterns during various phases of the cardiac-cycle. Increased stress-accumulations, but within the safety margin of acceptable thrombogenicity, were found in smaller TAHs, indicating that they are clinically viable. PMID:25354999

Recent clinical trials in valvular heart disease.

PubMed

Kiss, Daniel; Anwaruddin, Saif

2017-07-01

With widespread adoption of transcatheter aortic valve replacement, there has been a change in the approach to management of valvular heart disease. New interest has taken hold in transcatheter therapies for valvular heart disease, as well as research into pathophysiology and progression of disease. Additionally, several key trials have further refined our understanding of surgical management of valvular heart disease. This review will elucidate recent clinical trial data leading to changes in practice. There have been several landmark trials expanding the indications for transcatheter aortic valve replacement. Additionally, although still early, trials are beginning to demonstrate the feasibility and safety of transcatheter mitral valves. Options for transcatheter management of right-sided valvular disease continue to evolve, and these are areas of active investigation. The emergence of novel therapies for valvular heart disease has expanded the management options available, allowing physicians to better individualize treatment of patients with valvular heart disease. This review will focus on the recent (within 2 years) trials in this field of interest.

Clinical Trial Principles and Endpoint Definitions for Paravalvular Leaks in Surgical Prosthesis: An Expert Statement.

PubMed

Ruiz, Carlos E; Hahn, Rebecca T; Berrebi, Alain; Borer, Jeffrey S; Cutlip, Donald E; Fontana, Greg; Gerosa, Gino; Ibrahim, Reda; Jelnin, Vladimir; Jilaihawi, Hasan; Jolicoeur, E Marc; Kliger, Chad; Kronzon, Itzhak; Leipsic, Jonathon; Maisano, Francesco; Millan, Xavier; Nataf, Patrick; O'Gara, Patrick T; Pibarot, Philippe; Ramee, Stephen R; Rihal, Charanjit S; Rodes-Cabau, Josep; Sorajja, Paul; Suri, Rakesh; Swain, Julie A; Turi, Zoltan G; Tuzcu, E Murat; Weissman, Neil J; Zamorano, Jose L; Serruys, Patrick W; Leon, Martin B

2017-04-25

The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices. The PVL Academic Research Consortium met to review evidence and make recommendations for assessment of disease severity, data collection, and updated endpoint definitions. A 5-class grading scheme to evaluate PVL was developed in concordance with VARC recommendations. Unresolved issues in the field are outlined. The current PVL Academic Research Consortium provides recommendations for assessment of disease severity, data collection, and endpoint definitions. Future research in the field is warranted. Copyright © 2017 American College of Cardiology Foundation and European Society of Cardiology. Published by Elsevier Inc. All rights reserved.

Cardiopulmonary Exercise Testing in Patients with Asymptomatic or Equivocal Symptomatic Aortic Stenosis: Feasibility, Reproducibility, Safety and Information Obtained on Exercise Physiology.

PubMed

van Le, Douet; Jensen, Gunnar Vagn Hagemann; Carstensen, Steen; Kjøller-Hansen, Lars

2016-01-01

The aim of this study was to determine the feasibility, reproducibility, safety and information obtained on exercise physiology from cardiopulmonary exercise testing (CPX) in patients with aortic stenosis. Patients with an aortic valve area (AVA) <1.3 cm2 who were judged asymptomatic or equivocal symptomatic underwent CPX and an inert gas rebreathing test. Only those where comprehensive evaluation of CPX results indicated haemodynamic compromise from aortic stenosis were referred for valve replacement. The mean patient age was 72 (±9) years; an AVA index <0.6 cm2/m2 and equivocal symptomatic status were found in 90 and 70%, respectively. CPX was feasible in 130 of the 131 patients. The coefficients of repeatability by test-retest were 5.4% (pVO2) and 4.6% (peak O2 pulse). A pVO2 <83% of the expected was predicted by a lower stroke volume at exercise, lower peak heart rate and FEV1, and higher VE/VCO2, but not by AVA index. Equivocal symptomatic status and a low gradient but high valvulo-arterial impedance were associated with a lower pVO2, but not with an inability to increase stroke volume. In total, 18 patients were referred for valve replacement. At 1 year, no cardiovascular deaths had occurred. CPX was feasible and reproducible and provided comprehensive data on exercise physiology. A CPX-guided treatment strategy was safe up to 1 year. © 2015 S. Karger AG, Basel.

Effects of a 3D segmental prosthetic system for tricuspid valve annulus remodelling on the right coronary artery: a human cadaveric coronary angiography study.

PubMed

Riki-Marishani, Mohsen; Gholoobi, Arash; Sazegar, Ghasem; Aazami, Mathias H; Hedjazi, Aria; Sajjadian, Maryam; Ebrahimi, Mahmoud; Aghaii-Zade Torabi, Ahmad

2017-09-01

A prosthetic system to repair secondary tricuspid valve regurgitation was developed. The conceptual engineering of the current device is based on 3D segmental remodelling of the tricuspid valve annulus in lieu of reductive annuloplasty. This study was designed to investigate the operational safety of the current prosthetic system with regard to the anatomical integrity of the right coronary artery (RCA) in fresh cadaveric human hearts. During the study period, from January to April 2016, the current prosthetic system was implanted on the tricuspid valve annulus in fresh cadaveric human hearts that met the study's inclusion criteria. The prepared specimens were investigated via selective coronary angiography of the RCA in the catheterization laboratory. The RCA angiographic anatomies were categorized as normal, distorted, kinked or occluded. Sixteen specimens underwent implantation of the current prosthetic system. The mean age of the cadaveric human hearts was 43.24 ± 15.79 years, with vehicle accident being the primary cause of death (59%). A dominant RCA was noticed in 62.5% of the specimens. None of the specimens displayed any injury, distortion, kinking or occlusion in the RCA due to the implantation of the prostheses. In light of the results of the present study, undertaken on fresh cadaveric human heart specimens, the current segmental prosthetic system for 3D remodelling of the tricuspid valve annulus seems to be safe vis-à-vis the anatomical integrity of the RCA. Further in vivo studies are needed to investigate the functional features of the current prosthetic system with a view to addressing the complex pathophysiology of secondary tricuspid valve regurgitation. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

PREVAIL TRANSAPICAL: multicentre trial of transcatheter aortic valve implantation using the newly designed bioprosthesis (SAPIEN-XT) and delivery system (ASCENDRA-II).

PubMed

Walther, Thomas; Thielmann, Matthias; Kempfert, Joerg; Schroefel, Holger; Wimmer-Greinecker, Gerhard; Treede, Hendrik; Wahlers, Thorsten; Wendler, Olaf

2012-08-01

Transapical (TA) aortic valve implantation (AVI) has evolved as an alternative procedure for high-risk patients. We evaluated the second-generation SAPIEN XT™ prosthesis in a prospective multicentre clinical trial. A total of 150 patients (age: 81.6 ± 5.8 years; 40.7% female) were included. Prosthetic valves (diameter: 23 mm (n = 36), 26 mm (n = 57) and 29 mm (n = 57)) were implanted. The ASCENDRA-II™ modified delivery system was used in the smaller sizes. Mean logistic EuroSCORE was 24.3 ± 7.0%, and mean STS score 7.5 ± 4.4%. All patients gave written informed consent. Off-pump AVI was performed using femoral arterial and venous access wires as a safety net. All but two patients received TA-AVI, as planned. The 29-mm valve showed similar function as the values of two other diameters did. Three patients (2%) required temporary cardiopulmonary bypass support. Postoperative complications included renal failure requiring long-term dialysis in four, bleeding requiring rethoracotomy in four, respiratory complication requiring reintubation in eight and sepsis in four patients, respectively. Thirty-day mortality was 13 (8.7%) for the total cohort and 2/57 (3.5%) for patients receiving the 29-mm valve, respectively. Echocardiography at discharge showed none or trivial aortic incompetence (AI) in 71% and mild-AI in 22% of the patients. Post-implantation AI was predominantly paravalvular and ≥ 2+ in 7% of patients. One patient required reoperation for AI within 30 days. The PREVAIL TA multicentre trial demonstrates good functionality and good outcomes for TA-AVI, using the SAPIEN XT™ prosthesis and its second-generation ASCENDRA-II™ delivery system, as well successful introduction of the 29-mm SAPIEN XT™ valve for the benefit of high-risk elderly patients.

Embolic capture with updated intra-aortic filter during coronary artery bypass grafting and transaortic transcatheter aortic valve implantation: first-in-human experience.

PubMed

Ye, Jian; Webb, John G

2014-12-01

We report our first-in-human clinical experience in the use of the new version of the EMBOL-X intra-aortic filter (Edwards Lifesciences Corporation, Irvine, Calif) to capture embolic material during transaortic transcatheter aortic valve implantation and cardiac surgery. Five patients were enrolled into the first-in-human clinical assessment of the new version of the EMBOL-X intra-aortic filter. Three patients underwent coronary artery bypass grafting, and 2 patients underwent transaortic transcatheter aortic valve implantation. During coronary artery bypass grafting, the filter was deployed before clamping of the aorta and removal of the aortic clamp. In contrast, the filter was deployed before aortic puncture for transaortic transcatheter aortic valve implantation and kept in the aorta throughout the entire procedure. The filter introducer sheath and filter were easily placed and removed without difficulty. There were no complications related to the use of the filter. Postoperative examination of the retrieved filters revealed the presence of multiple microemboli in the filters from all 5 cases. Histologic study revealed various kinds of tissue and thrombus. This first-in-human clinical experience has demonstrated the safety and feasibility of using the new version of the EMBOL-X intra-aortic filter during either cardiac surgery or transaortic transcatheter aortic valve implantation. We believe that the combination of the transaortic approach without aortic arch manipulation and the use of the EMBOL-X filter with a high capture rate is a promising strategy to reduce the incidence of embolic complications during transcatheter aortic valve implantation. Copyright © 2014 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

Magnetic-adhesive based valves for microfluidic devices used in low-resource settings.

PubMed

Harper, Jason C; Andrews, Jenna M; Ben, Candice; Hunt, Andrew C; Murton, Jaclyn K; Carson, Bryan D; Bachand, George D; Lovchik, Julie A; Arndt, William D; Finley, Melissa R; Edwards, Thayne L

2016-10-18

Since the introduction of micro total analytical systems (μTASs), significant advances have been made toward development of lab-on-a-chip platforms capable of performing complex biological assays that can revolutionize public health, among other applications. However, use of these platforms in low-resource environments (e.g. developing countries) has yet to be realized as the majority of technologies used to control microfluidic flow rely on off-device hardware with non-negligible size, cost, power requirements and skill/training to operate. In this paper we describe a magnetic-adhesive based valve that is simple to construct and operate, and can be used to control fluid flow and store reagents within a microfluidic device. The design consists of a port connecting two chambers on different planes in the device that is closed by a neodymium disk magnet seated on a thin ring of adhesive. Bringing an external magnet into contact with the outer surface of the device unseats and displaces the valve magnet from the adhesive ring, exposing the port. Using this configuration, we demonstrate on-device reagent storage and on-demand transport and reaction of contents between chambers. This design requires no power or external instrumentation to operate, is extremely low cost ($0.20 materials cost per valve), can be used by individuals with no technical training, and requires only a hand-held magnet to actuate. Additionally, valve actuation does not compromise the integrity of the completely sealed microfluidic device, increasing safety for the operator when toxic or harmful substances are contained within. This valve concept has the potential to simplify design of μTASs, facilitating development of lab-on-a-chip systems that may be practical for use in point-of-care and low-resource settings.

Transcatheter aortic valve replacement: historical perspectives, current evidence, and future directions.

PubMed

Horne, Aaron; Reineck, Elizabeth A; Hasan, Rani K; Resar, Jon R; Chacko, Matthews

2014-10-01

Severe aortic stenosis (AS) results in considerable morbidity and mortality without aortic valve replacement and is expected to increase in prevalence with the aging population. Because AS primarily affects the elderly, many patients with comorbidities are poor candidates for surgical aortic valve replacement (SAVR) and may not be referred. Transcatheter aortic valve replacement (TAVR) has emerged as transformative technology for the management of AS over the past decade. Randomized trials have established the safety and efficacy of TAVR with improved mortality and quality of life compared with medical therapy in inoperable patients, while demonstrating noninferiority and even superiority to SAVR among high-risk operative candidates. However, early studies demonstrated an early penalty of stroke and vascular complications with TAVR as well as increased paravalvular leak as compared with SAVR. Two device platforms have been evaluated and approved for use in the United States: the Edwards SAPIEN and the Medtronic CoreValve. Early studies also suggest cost-effectiveness for TAVR. Ongoing studies are evaluating new iterations of the aforementioned TAVR devices, novel device designs, and applications of TAVR in expanded populations of patients including those with lower risk profiles as well as those with comorbidities that were excluded from early clinical trials. Future improvements in TAVR technology will likely reduce periprocedural and long-term complications. Further studies are needed to confirm device durability over long-term follow-up and explore the applicability of TAVR to broader AS patient populations. Copyright © 2014 Mosby, Inc. All rights reserved.

Early Feasibility Study of a Transcatheter Tricuspid Valve Annuloplasty: SCOUT Trial 30-Day Results.

PubMed

Hahn, Rebecca T; Meduri, Christopher U; Davidson, Charles J; Lim, Scott; Nazif, Tamim M; Ricciardi, Mark J; Rajagopal, Vivek; Ailawadi, Gorav; Vannan, Mani A; Thomas, James D; Fowler, Dale; Rich, Stuart; Martin, Randy; Ong, Geraldine; Groothuis, Adam; Kodali, Susheel

2017-04-11

The SCOUT (Percutaneous Tricuspid Valve Annuloplasty System for Symptomatic Chronic Functional Tricuspid Regurgitation) trial is a prospective, single-arm, multicenter, early feasibility study of a novel transcatheter device to plicate the tricuspid annulus (TA) and reduce tricuspid regurgitation (TR). This study tested the feasibility and safety of a novel transcatheter device and assessed its early performance and functional outcomes. Between November 2015 and June 2016, 15 patients with New York Heart Association (NYHA) functional class ≥II and moderate or greater functional TR were enrolled. Primary performance and safety endpoint outcomes were technically successful at 30 days with no reintervention. Echocardiographic measurements (TA diameter, effective regurgitant orifice area [EROA], left ventricular stroke volume [LVSV]) and quality-of-life (QoL) measurements (NYHA functional class, Minnesota Living with Heart Failure Questionnaire [MLHFQ], and 6-min walk test [6MWT]) were performed at baseline and 30 days. All patients (mean 73.2 ± 6.9 years of age, 87% female) underwent successful device implantation with no deaths, strokes, bleeding, tamponade, or valve reintervention. Technical success rate at 30 days was 80%, with 3 single-pledget annular detachments without reintervention. In the remaining 12 patients, there were significant reductions in TA (12.3 ± 3.1 cm 2 to 11.3 ± 2.7 cm 2 , respectively; p = 0.019) and EROA (0.51 ± 0.18 cm 2 vs. 0.32 ± 0.18 cm 2 , respectively; p = 0.020), with significant increase in LVSV (63.6 ± 17.9 ml vs. 71.5 ± 25.7 ml, respectively; p = 0.021). In the intention-to-treat cohort, there were significant improvements in NYHA functional class (≥1 class, p = 0.001), MLHFQ (47.4 ± 17.6 to 20.9 ± 14.8; p < 0.001), and 6MWT (245.2 ± 110.1 to 298.0 m ± 107.6 m; p = 0.008). The 30-day results of the SCOUT trial confirmed the safety of the novel transcatheter device, which reduced TA and EROA, increased LVSV, and improved QoL. (Early Feasibility of the Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Also Known as TriAlign [SCOUT]; NCT02574650.). Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Final 5-year clinical and echocardiographic results for treatment of severe aortic stenosis with a self-expanding bioprosthesis from the ADVANCE Study

PubMed Central

Gerckens, Ulrich; Tamburino, Corrado; Bleiziffer, Sabine; Bosmans, Johan; Wenaweser, Peter; Brecker, Stephen; Guo, Jia; Linke, Axel

2017-01-01

Abstract Aims The ADVANCE study was designed to evaluate the safety and effectiveness of transcatheter aortic valve implantation (TAVI) with a self-expanding bioprosthesis in real-world patients with symptomatic, severe aortic stenosis at high surgical risk for valve replacement. Methods and results Study participants were enrolled from 44 experienced centres in 12 countries. Patient eligibility, treatment approach, and choice of anaesthesia were determined by the local Heart Team. The study was 100% monitored, and adverse events were adjudicated by an independent clinical events committee using Valve Academic Research Consortium (VARC-1) criteria. There were 1015 patients enrolled with 996 attempted TAVI procedures. Mean age was 81 years, and mean logistic EuroSCORE was 19.3 ± 12.3%. Five-year follow-up was available on 465 (46.7%) patients. At 5 years, the rate of all-cause mortality was 50.7% (95% confidence interval: 46.7%, 54.5%), and the rate of major stroke was 5.4%. Haemodynamic measures remained consistent for paired patients with a mean aortic valve gradient of 8.8 ± 4.4 mmHg (n = 198) and an effective orifice area of 1.7 ± 0.4 cm2 (n = 123). Aortic regurgitation (AR) decreased over time and among paired patients dropped from 12.8% to 8.0% moderate AR at 5 years (n = 125). Of the 860 patients with echocardiographic data or a reintervention after 30 days, there were 22 (2.6%) patients meeting the VARC-2 criteria for valve dysfunction and 10 (1.2%) patients with a reintervention >30 days. Conclusion Five-year results in real-world, elderly, high-risk patients undergoing TAVI with a self-expanding bioprosthesis provided evidence for continued valve durability with low rates of reinterventions and haemodynamic valve dysfunction. Trial registration ClinicalTrials.gov, NCT01074658. PMID:28633375

46 CFR 38.20-5 - Venting-T/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Venting-T/ALL. 38.20-5 Section 38.20-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS LIQUEFIED FLAMMABLE GASES Venting and Ventilation § 38.20-5 Venting—T/ALL. (a) Safety relief valves on cargo tanks in barges may be connected to...

46 CFR 38.20-5 - Venting-T/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Venting-T/ALL. 38.20-5 Section 38.20-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS LIQUEFIED FLAMMABLE GASES Venting and Ventilation § 38.20-5 Venting—T/ALL. (a) Safety relief valves on cargo tanks in barges may be connected to...

49 CFR 179.300-13 - Venting, loading and unloading valves.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-13 Venting... (h)(3)(ii). Threads for the clean-out/inspection ports of DOT Specification 110A multi-unit tank car...

30 CFR 250.447 - When must I pressure test the BOP system?

Code of Federal Regulations, 2013 CFR

2013-07-01

... THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.447 When must I pressure test the BOP... BOP, and drill-string safety valve): (a) When installed; (b) Before 14 days have elapsed since your...

30 CFR 250.447 - When must I pressure test the BOP system?

Code of Federal Regulations, 2012 CFR

2012-07-01

... THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.447 When must I pressure test the BOP... BOP, and drill-string safety valve): (a) When installed; (b) Before 14 days have elapsed since your...

30 CFR 250.447 - When must I pressure test the BOP system?

Code of Federal Regulations, 2014 CFR

2014-07-01

... THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.447 When must I pressure test the BOP... BOP, and drill-string safety valve): (a) When installed; (b) Before 14 days have elapsed since your...

76 FR 22148 - Petitions for Modification of Application of Existing Mandatory Safety Standards

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

..., grounded phase, under-voltage, and ground monitoring protection; (b) the trailing cable short-circuit... activated; (c) the solenoid valves will be connected to the CO monitoring system through PLC programming... surface location, either the CO monitoring room or the security station. Either, two miners on each shift...

46 CFR 38.10-15 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... plus the maximum flow rate of the cargo filling pipes or, (2) The vapors generated under fire exposure..., constructed and flow tested for capacity in conformance with subpart 162.017 or 162.018 of subchapter Q... excessive external pressure. (f) Void spaces between the primary and secondary barriers of nonpressure...

46 CFR 38.10-15 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... plus the maximum flow rate of the cargo filling pipes or, (2) The vapors generated under fire exposure..., constructed and flow tested for capacity in conformance with subpart 162.017 or 162.018 of subchapter Q... excessive external pressure. (f) Void spaces between the primary and secondary barriers of nonpressure...

46 CFR 38.10-15 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... plus the maximum flow rate of the cargo filling pipes or, (2) The vapors generated under fire exposure..., constructed and flow tested for capacity in conformance with subpart 162.017 or 162.018 of subchapter Q... excessive external pressure. (f) Void spaces between the primary and secondary barriers of nonpressure...

46 CFR 38.10-15 - Safety relief valves-TB/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... plus the maximum flow rate of the cargo filling pipes or, (2) The vapors generated under fire exposure..., constructed and flow tested for capacity in conformance with subpart 162.017 or 162.018 of subchapter Q... excessive external pressure. (f) Void spaces between the primary and secondary barriers of nonpressure...

46 CFR 162.018-4 - Construction and workmanship.

Code of Federal Regulations, 2011 CFR

2011-10-01

... external spring-loaded type, suitable for the intended service. (b) Safety relief valve body, base, bonnet... with side or top outlet discharge connections. (f)(1) Springs shall not show a permanent set exceeding... the spring solid. (2) Springs may not be re-set for any pressure more than 10 percent above or 10...

46 CFR 162.018-4 - Construction and workmanship.

Code of Federal Regulations, 2012 CFR

2012-10-01

... external spring-loaded type, suitable for the intended service. (b) Safety relief valve body, base, bonnet... with side or top outlet discharge connections. (f)(1) Springs shall not show a permanent set exceeding... the spring solid. (2) Springs may not be re-set for any pressure more than 10 percent above or 10...

46 CFR 162.018-4 - Construction and workmanship.

Code of Federal Regulations, 2010 CFR

2010-10-01

... external spring-loaded type, suitable for the intended service. (b) Safety relief valve body, base, bonnet... with side or top outlet discharge connections. (f)(1) Springs shall not show a permanent set exceeding... the spring solid. (2) Springs may not be re-set for any pressure more than 10 percent above or 10...

46 CFR 162.018-4 - Construction and workmanship.

Code of Federal Regulations, 2013 CFR

2013-10-01

... external spring-loaded type, suitable for the intended service. (b) Safety relief valve body, base, bonnet... with side or top outlet discharge connections. (f)(1) Springs shall not show a permanent set exceeding... the spring solid. (2) Springs may not be re-set for any pressure more than 10 percent above or 10...

46 CFR 162.018-4 - Construction and workmanship.

Code of Federal Regulations, 2014 CFR

2014-10-01

... external spring-loaded type, suitable for the intended service. (b) Safety relief valve body, base, bonnet... with side or top outlet discharge connections. (f)(1) Springs shall not show a permanent set exceeding... the spring solid. (2) Springs may not be re-set for any pressure more than 10 percent above or 10...

49 CFR 229.49 - Main reservoir system.

Code of Federal Regulations, 2014 CFR

2014-10-01

... least one safety valve that shall prevent an accumulation of pressure of more than 15 pounds per square... or unloads and loads the air compressor within 5 pounds per square inch above or below the maximum... pressure is not less than 15 pounds per square inch above the maximum brake pipe pressure fixed by the...

49 CFR 229.49 - Main reservoir system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... least one safety valve that shall prevent an accumulation of pressure of more than 15 pounds per square... or unloads and loads the air compressor within 5 pounds per square inch above or below the maximum... pressure is not less than 15 pounds per square inch above the maximum brake pipe pressure fixed by the...

TriGuard™ HDH embolic deflection device for cerebral protection during transcatheter aortic valve replacement.

PubMed

Samim, Mariam; van der Worp, Bart; Agostoni, Pierfrancesco; Hendrikse, Jeroen; Budde, Ricardo P J; Nijhoff, Freek; Ramjankhan, Faiz; Doevendans, Pieter A; Stella, Pieter R

2017-02-15

This study aims to evaluate the safety and performance of the new embolic deflection device TriGuard™HDH in patients undergoing TAVR. Transcatheter aortic valve replacement (TAVR) is associated with a high incidence of new cerebral ischemic lesions. The use of an embolic protection device may reduce the frequency of TAVR-related embolic events. This prospective, single arm feasibility pilot study included 14 patients with severe symptomatic aortic stenosis scheduled for TAVR. Cerebral diffusion weighted magnetic resonance imaging (DWI) was planned in all patients one day before and at day 4 (±2) after the procedure. Major adverse cerebral and cardiac events (MACCEs) were recorded for all patients. Primary endpoints of this study were I) device performance success defined as coverage of the aortic arch takeoffs throughout the entire TAVR procedure and II) MACCE occurrence. Secondary endpoints included the number and the volume of new cerebral ischemic lesions on DWI. Thirteen patients underwent transfemoral TAVR and one patient a transapical procedure. Edwards SAPIEN valve prosthesis was implanted in 8 (57%) patients and Medtronic CoreValve prosthesis in the remaining 6 (43%). Predefined performance success of the TriGuard™HDH device was achieved in 9 (64%) patients. The composite endpoint MACCE occurred in none of the patients. Post-procedural DWI was performed in 11 patients. Comparing the DWI of these patients to a historical control group showed no reduction in number [median 5.5 vs. 5.0, P = 0.857], however there was a significant reduction in mean lesion volume per patient [median 13.8 vs. 25.1, P = 0.049]. This study showed the feasibility and safety of using the TriGuard™HDH for cerebral protection during TAVR. This device did not decrease the number of post-procedural new cerebral DWI lesions, however its use showed decreased lesion volume as compared to unprotected TAVR. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Recent developments in high altitude aircraft sampling - Mount St. Helens and stratospheric trace gases

NASA Astrophysics Data System (ADS)

Leifer, R.; Sommers, K. G.; Guggenheim, S. F.; Fisenne, I.

1981-02-01

An ultra-clean, low volume gas sampling system (CLASS), flown aboard a high altitude aircraft (WB-57F), and providing information on stratospheric trace gases is presented. Attention is given to the instrument design and the electronic control design. Since remote operation is mandatory on the WB-57F, a servo pressure transducer, electrical pressure switch for automatic shutdown, and a mechanical safety relief valve were installed on the sampling manifold, indicated on the CLASS flow chart. The electronic control system consists of hermetically sealed solid state timers, relays, and a stepping switch, for controlling the compressor pump and solenoid valves. In designing the automatic control system, vibration, shock, acceleration, extreme low temperature, and aircraft safety were important considerations. CLASS was tested on three separate occasions, and tables of analytical data from these flights are presented. Readiness capability was demonstrated when the Mount St. Helens eruption plume of May 18, 1980, was intercepted, and it was concluded that no large injection of Rn-222 entered the stratosphere or troposphere from the eruption.

Transaortic edge-to-edge mitral valve repair for moderate secondary/functional mitral regurgitation in patients undergoing aortic root/valve intervention.

PubMed

Choudhary, Shiv Kumar; Abraham, Atul; Bhoje, Amol; Gharde, Parag; Sahu, Manoj; Talwar, Sachin; Airan, Balram

2017-11-01

The present study evaluates the feasibility, safety, and efficacy of edge-to-edge repair for moderate secondary/functional mitral regurgitation in patients undergoing aortic valve/root interventions. Sixteen patients underwent transaortic edge-to-edge mitral valve repair. Mitral regurgitation was 2+ in 8 patients and 3+ in 6 patients. Two patients in whom cardiac arrest developed preoperatively had severe (4+) mitral regurgitation. Patients underwent operation for severe aortic regurgitation ± aortic root lesions. The mean left ventricular systolic and diastolic diameters were 51.5 ± 12.8 mm and 70.7 ± 10.7 mm, respectively. Left ventricular ejection fraction ranged from 20% to 60%. Primary surgical procedure included Bentall's ± hemiarch replacement in 10 patients, aortic valve replacement in 5 patients, and noncoronary sinus replacement with aortic valve repair in 1 patient. Severity of mitral regurgitation decreased to trivial or zero in 13 patients, 1+ in 2 patients, and 2+ in 1 patient. There were no gradients across the mitral valve in 9 patients, less than 5 mm Hg in 6 patients, and 9 mm Hg in 1 patient. There was no operative mortality. Follow-up ranged from 2 weeks to 54 months. Echocardiography showed trivial or no mitral regurgitation in 12 patients, 1+ in 2 patients, and 2+ in 2 patients. None of the patients had significant mitral stenosis. The mean left ventricular systolic and diastolic diameters decreased to 40.5 ± 10.3 mm and 58.7 ± 11.6 mm, respectively. Ejection fraction also improved slightly (22%-65%). Transaortic edge-to-edge mitral valve repair is a safe and effective technique to abolish secondary/functional mitral regurgitation. However, its impact on overall survival needs to be studied. Copyright © 2017 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

Integrating biofiltration with SVE: A case study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lesley, M.P.; Rangan, C.R.

1996-12-01

A prototype integrated soil vacuum extraction/biofiltration system has been designed and installed at a gasoline contaminated LUST site in southern Delaware. The prototype system remediates contaminated moisture entrained in the air stream, employs automatic water level controls in the filters, and achieves maximum vapor extraction and VOC destruction efficiency with an optimum power input. In addition, the valving and piping layout allows the direction of air flow through the filters to be reversed at a given time interval, which minimizes biofouling, thereby increasing efficiency by minimizing the need for frequent cleaning. This integrated system achieves constant VOC destruction rates ofmore » 40 to 70% while maintaining optimal VOC removal rates from the subsurface. The modular design allows for easy mobilization, setup and demobilization at state-lead LUST sites throughout Delaware.« less

High Reynolds Number Hybrid Laminar Flow Control (HLFC) Flight Experiment. Report 4; Suction System Design and Manufacture

NASA Technical Reports Server (NTRS)

1999-01-01

This document describes the design of the leading edge suction system for flight demonstration of hybrid laminar flow control on the Boeing 757 airplane. The exterior pressures on the wing surface and the required suction quantity and distribution were determined in previous work. A system consisting of porous skin, sub-surface spanwise passages ("flutes"), pressure regulating screens and valves, collection fittings, ducts and a turbocompressor was defined to provide the required suction flow. Provisions were also made for flexible control of suction distribution and quantity for HLFC research purposes. Analysis methods for determining pressure drops and flow for transpiration heating for thermal anti-icing are defined. The control scheme used to observe and modulate suction distribution in flight is described.

Preliminary analysis of loss-of-coolant accident in Fukushima nuclear accident

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su'ud, Zaki; Anshari, Rio

Loss-of-Coolant Accident (LOCA) in Boiling Water Reactor (BWR) especially on Fukushima Nuclear Accident will be discussed in this paper. The Tohoku earthquake triggered the shutdown of nuclear power reactors at Fukushima Nuclear Power station. Though shutdown process has been completely performed, cooling process, at much smaller level than in normal operation, is needed to remove decay heat from the reactor core until the reactor reach cold-shutdown condition. If LOCA happen at this condition, it will cause the increase of reactor fuel and other core temperatures and can lead to reactor core meltdown and exposure of radioactive material to the environmentmore » such as in the Fukushima Dai Ichi nuclear accident case. In this study numerical simulation has been performed to calculate pressure composition, water level and temperature distribution on reactor during this accident. There are two coolant regulating system that operational on reactor unit 1 at this accident, Isolation Condensers (IC) system and Safety Relief Valves (SRV) system. Average mass flow of steam to the IC system in this event is 10 kg/s and could keep reactor core from uncovered about 3,2 hours and fully uncovered in 4,7 hours later. There are two coolant regulating system at operational on reactor unit 2, Reactor Core Isolation Condenser (RCIC) System and Safety Relief Valves (SRV). Average mass flow of coolant that correspond this event is 20 kg/s and could keep reactor core from uncovered about 73 hours and fully uncovered in 75 hours later. There are three coolant regulating system at operational on reactor unit 3, Reactor Core Isolation Condenser (RCIC) system, High Pressure Coolant Injection (HPCI) system and Safety Relief Valves (SRV). Average mass flow of water that correspond this event is 15 kg/s and could keep reactor core from uncovered about 37 hours and fully uncovered in 40 hours later.« less

Preliminary analysis of loss-of-coolant accident in Fukushima nuclear accident

NASA Astrophysics Data System (ADS)

Su'ud, Zaki; Anshari, Rio

2012-06-01

Loss-of-Coolant Accident (LOCA) in Boiling Water Reactor (BWR) especially on Fukushima Nuclear Accident will be discussed in this paper. The Tohoku earthquake triggered the shutdown of nuclear power reactors at Fukushima Nuclear Power station. Though shutdown process has been completely performed, cooling process, at much smaller level than in normal operation, is needed to remove decay heat from the reactor core until the reactor reach cold-shutdown condition. If LOCA happen at this condition, it will cause the increase of reactor fuel and other core temperatures and can lead to reactor core meltdown and exposure of radioactive material to the environment such as in the Fukushima Dai Ichi nuclear accident case. In this study numerical simulation has been performed to calculate pressure composition, water level and temperature distribution on reactor during this accident. There are two coolant regulating system that operational on reactor unit 1 at this accident, Isolation Condensers (IC) system and Safety Relief Valves (SRV) system. Average mass flow of steam to the IC system in this event is 10 kg/s and could keep reactor core from uncovered about 3,2 hours and fully uncovered in 4,7 hours later. There are two coolant regulating system at operational on reactor unit 2, Reactor Core Isolation Condenser (RCIC) System and Safety Relief Valves (SRV). Average mass flow of coolant that correspond this event is 20 kg/s and could keep reactor core from uncovered about 73 hours and fully uncovered in 75 hours later. There are three coolant regulating system at operational on reactor unit 3, Reactor Core Isolation Condenser (RCIC) system, High Pressure Coolant Injection (HPCI) system and Safety Relief Valves (SRV). Average mass flow of water that correspond this event is 15 kg/s and could keep reactor core from uncovered about 37 hours and fully uncovered in 40 hours later.

AMISS - Active and passive MIcrowaves for Security and Subsurface imaging

NASA Astrophysics Data System (ADS)

Soldovieri, Francesco; Slob, Evert; Turk, Ahmet Serdar; Crocco, Lorenzo; Catapano, Ilaria; Di Matteo, Francesca

2013-04-01

The FP7-IRSES project AMISS - Active and passive MIcrowaves for Security and Subsurface imaging is based on a well-combined network among research institutions of EU, Associate and Third Countries (National Research Council of Italy - Italy, Technische Universiteit Delft - The Netherlands, Yildiz Technical University - Turkey, Bauman Moscow State Technical University - Russia, Usikov Institute for Radio-physics and Electronics and State Research Centre of Superconductive Radioelectronics "Iceberg" - Ukraine and University of Sao Paulo - Brazil) with the aims of achieving scientific advances in the framework of microwave and millimeter imaging systems and techniques for security and safety social issues. In particular, the involved partners are leaders in the scientific areas of passive and active imaging and are sharing their complementary knowledge to address two main research lines. The first one regards the design, characterization and performance evaluation of new passive and active microwave devices, sensors and measurement set-ups able to mitigate clutter and increase information content. The second line faces the requirements to make State-of-the-Art processing tools compliant with the instrumentations developed in the first line, suitable to work in electromagnetically complex scenarios and able to exploit the unexplored possibilities offered by new instrumentations. The main goals of the project are: 1) Development/improvement and characterization of new sensors and systems for active and passive microwave imaging; 2) Set up, analysis and validation of state of art/novel data processing approach for GPR in critical infrastructure and subsurface imaging; 3) Integration of state of art and novel imaging hardware and characterization approaches to tackle realistic situations in security, safety and subsurface prospecting applications; 4) Development and feasibility study of bio-radar technology (system and data processing) for vital signs detection and detection/characterization of human beings in complex scenarios. These goals are planned to be reached following a plan of research activities and researchers secondments which cover a period of three years. ACKNOWLEDGMENTS This research has been performed in the framework of the "Active and Passive Microwaves for Security and Subsurface imaging (AMISS)" EU 7th Framework Marie Curie Actions IRSES project (PIRSES-GA-2010-269157).

Statins for aortic valve stenosis.

PubMed

Thiago, Luciana; Tsuji, Selma Rumiko; Nyong, Jonathan; Puga, Maria Eduarda Dos Santos; Góis, Aécio Flávio Teixeira de; Macedo, Cristiane Rufino; Valente, Orsine; Atallah, Álvaro Nagib

2016-01-01

Aortic valve stenosis is the most common type of valvular heart disease in the USA and Europe. Aortic valve stenosis is considered similar to atherosclerotic disease. Some studies have evaluated statins for aortic valve stenosis. To evaluate the effectiveness and safety of statins in aortic valve stenosis. Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, LILACS - IBECS, Web of Science and CINAHL Plus. These databases were searched from their inception to 24 November 2015. We also searched trials in registers for ongoing trials. We used no language restrictions.Selection criteria: Randomized controlled clinical trials (RCTs) comparing statins alone or in association with other systemic drugs to reduce cholesterol levels versus placebo or usual care. Data collection and analysis: Primary outcomes were severity of aortic valve stenosis (evaluated by echocardiographic criteria: mean pressure gradient, valve area and aortic jet velocity), freedom from valve replacement and death from cardiovascular cause. Secondary outcomes were hospitalization for any reason, overall mortality, adverse events and patient quality of life.Two review authors independently selected trials for inclusion, extracted data and assessed the risk of bias. The GRADE methodology was employed to assess the quality of result findings and the GRADE profiler (GRADEPRO) was used to import data from Review Manager 5.3 to create a 'Summary of findings' table. We included four RCTs with 2360 participants comparing statins (1185 participants) with placebo (1175 participants). We found low-quality evidence for our primary outcome of severity of aortic valve stenosis, evaluated by mean pressure gradient (mean difference (MD) -0.54, 95% confidence interval (CI) -1.88 to 0.80; participants = 1935; studies = 2), valve area (MD -0.07, 95% CI -0.28 to 0.14; participants = 127; studies = 2), and aortic jet velocity (MD -0.06, 95% CI -0.26 to 0.14; participants = 155; study = 1). Moderate-quality evidence showed no effect on freedom from valve replacement with statins (risk ratio (RR) 0.93, 95% CI 0.81 to 1.06; participants = 2360; studies = 4), and no effect on muscle pain as an adverse event (RR 0.91, 95% CI 0.75 to 1.09; participants = 2204; studies = 3; moderate-quality evidence). Low- and very low-quality evidence showed uncertainty around the effect of statins on death from cardiovascular cause (RR 0.80, 95% CI 0.56 to 1.15; participants = 2297; studies = 3; low-quality evidence) and hospitalization for any reason (RR 0.84, 95% CI 0.39 to 1.84; participants = 155; study = 1; very low-quality evidence). None of the four included studies reported on overall mortality and patient quality of life. Result findings showed uncertainty surrounding the effect of statins for aortic valve stenosis. The quality of evidence from the reported outcomes ranged from moderate to very low. These results give support to European and USA guidelines (2012 and 2014, respectively) that so far there is no clinical treatment option for aortic valve stenosis.

Continual in situ monitoring of pore water stable isotopes in the subsurface

NASA Astrophysics Data System (ADS)

Volkmann, T. H. M.; Weiler, M.

2014-05-01

Stable isotope signatures provide an integral fingerprint of origin, flow paths, transport processes, and residence times of water in the environment. However, the full potential of stable isotopes to quantitatively characterize subsurface water dynamics is yet unfolded due to the difficulty in obtaining extensive, detailed, and repeated measurements of pore water in the unsaturated and saturated zone. This paper presents a functional and cost-efficient system for non-destructive continual in situ monitoring of pore water stable isotope signatures with high resolution. Automatic controllable valve arrays are used to continuously extract diluted water vapor in soil air via a branching network of small microporous probes into a commercial laser-based isotope analyzer. Normalized liquid-phase isotope signatures are then obtained based on a specific on-site calibration approach along with basic corrections for instrument bias and temperature dependent isotopic fractionation. The system was applied to sample depth profiles on three experimental plots with varied vegetation cover in southwest Germany. Two methods (i.e., based on advective versus diffusive vapor extraction) and two modes of sampling (i.e., using multiple permanently installed probes versus a single repeatedly inserted probe) were tested and compared. The results show that the isotope distribution along natural profiles could be resolved with sufficiently high accuracy and precision at sampling intervals of less than four minutes. The presented in situ approaches may thereby be used interchangeably with each other and with concurrent laboratory-based direct equilibration measurements of destructively collected samples. It is thus found that the introduced sampling techniques provide powerful tools towards a detailed quantitative understanding of dynamic and heterogeneous shallow subsurface and vadose zone processes.

BRINGING SCIENCE AND PLANNING TOGETHER: A CASE STUDY ON PROTECTING HUMAN HEALTH, SAFETY, AND WELFARE FROM VAPOR INTRUSION

EPA Science Inventory

Vapor intrusion is the movement of volatile chemicals in the subsurface that eventually contaminate the indoor air that people breathe in overlaying buildings. This often overlooked exposure pathway of hazardous chemicals is a significant environmental health hazard. The USEPA ...

43 CFR 3275.12 - What environmental and safety requirements apply to facility operations?

Code of Federal Regulations, 2011 CFR

2011-10-01

... that: (1) Protects the quality of surface and subsurface waters, air, and other natural resources, including wildlife, soil, vegetation, and natural history; (2) Prevents unnecessary or undue degradation of the lands; (3) Protects the quality of cultural, scenic, and recreational resources; (4) Accommodates...

77 FR 59408 - Finding of Equivalence; Alternate Pressure Relief Valve Settings on Certain Vessels Carrying...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-27

... allowable stress factors for type B and type C independent cargo tanks are more stringent than the... inspections have advanced since the Coast Guard first promulgated regulations on allowable stress factors on... allowable stress factors provide a level of safety protection equivalent to the standards in 46 CFR 154.447...

30 CFR 250.802 - Design, installation, and operation of surface production-safety systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... properly or if any fluid flow is observed during the leakage test, the valve shall be repaired or replaced... maintenance of all fire- and gas-detection systems shall include the following: (i) Type, location, and number of detection sensors; (ii) Type and kind of alarms, including emergency equipment to be activated...

33 CFR 183.590 - Fire test.

Code of Federal Regulations, 2014 CFR

2014-07-01

... SAFETY BOATS AND ASSOCIATED EQUIPMENT Fuel Systems Tests § 183.590 Fire test. (a) A piece of equipment is tested under the following conditions and procedures: (1) Fuel stop valves, “USCG Type A1” or USCG Type... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Fire test. 183.590 Section 183...

33 CFR 183.590 - Fire test.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SAFETY BOATS AND ASSOCIATED EQUIPMENT Fuel Systems Tests § 183.590 Fire test. (a) A piece of equipment is tested under the following conditions and procedures: (1) Fuel stop valves, “USCG Type A1” or USCG Type... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Fire test. 183.590 Section 183...

33 CFR 183.590 - Fire test.

Code of Federal Regulations, 2012 CFR

2012-07-01

... SAFETY BOATS AND ASSOCIATED EQUIPMENT Fuel Systems Tests § 183.590 Fire test. (a) A piece of equipment is tested under the following conditions and procedures: (1) Fuel stop valves, “USCG Type A1” or USCG Type... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Fire test. 183.590 Section 183...

33 CFR 183.590 - Fire test.

Code of Federal Regulations, 2013 CFR

2013-07-01

... SAFETY BOATS AND ASSOCIATED EQUIPMENT Fuel Systems Tests § 183.590 Fire test. (a) A piece of equipment is tested under the following conditions and procedures: (1) Fuel stop valves, “USCG Type A1” or USCG Type... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Fire test. 183.590 Section 183...

76 FR 37115 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-24

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort AGENCY: National Institute for Occupational Safety and Health... determination concerning a petition to add a class of employees from the Chapman Valve Manufacturing Company (i...

Compressed gas manifold

DOEpatents

Hildebrand, Richard J.; Wozniak, John J.

2001-01-01

A compressed gas storage cell interconnecting manifold including a thermally activated pressure relief device, a manual safety shut-off valve, and a port for connecting the compressed gas storage cells to a motor vehicle power source and to a refueling adapter. The manifold is mechanically and pneumatically connected to a compressed gas storage cell by a bolt including a gas passage therein.

Improving Learning and Reducing Costs: Fifteen Years of Course Description

ERIC Educational Resources Information Center

Twigg, Carol A.

2015-01-01

Recognizing that tuition increases can no longer be used as a safety valve to avoid dealing with the underlying issues of why costs increase so much, campuses have begun the hard work of cost containment. After sharpening priorities, sometimes making tough choices in light of those priorities, campuses are still groping for ways to wrestle costs…

77 FR 22637 - Federal Motor Vehicle Safety Standards; Accelerator Control Systems

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-16

... severing a conductor at one location. The current language of the test procedure in FMVSS No. 124 is... routinely have variable valve lift and/or timing control. In at least one recent engine design, the level of.... Under the 2002 NPRM, a manufacturer could choose any one of the proposed test procedures as a basis for...

The AP1000{sup R} nuclear power plant innovative features for extended station blackout mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vereb, F.; Winters, J.; Schulz, T.

2012-07-01

Station Blackout (SBO) is defined as 'a condition wherein a nuclear power plant sustains a loss of all offsite electric power system concurrent with turbine trip and unavailability of all onsite emergency alternating current (AC) power system. Station blackout does not include the loss of available AC power to buses fed by station batteries through inverters or by alternate AC sources as defined in this section, nor does it assume a concurrent single failure or design basis accident...' in accordance with Reference 1. In this paper, the innovative features of the AP1000 plant design are described with their operation inmore » the scenario of an extended station blackout event. General operation of the passive safety systems are described as well as the unique features which allow the AP1000 plant to cope for at least 7 days during station blackout. Points of emphasis will include: - Passive safety system operation during SBO - 'Fail-safe' nature of key passive safety system valves; automatically places the valve in a conservatively safe alignment even in case of multiple failures in all power supply systems, including normal AC and battery backup - Passive Spent Fuel Pool cooling and makeup water supply during SBO - Robustness of AP1000 plant due to the location of key systems, structures and components required for Safe Shutdown - Diverse means of supplying makeup water to the Passive Containment Cooling System (PCS) and the Spent Fuel Pool (SFP) through use of an engineered, safety-related piping interface and portable equipment, as well as with permanently installed onsite ancillary equipment. (authors)« less

Preventive echocardiographic examination in athletes and workers - Quadricuspid aortic valve and atrial septal aneurysm in a young basketball player.

PubMed

Wierzbowska-Drabik, Karina; Marcinkiewicz, Andrzej; Kasprzak, Jarosław Damian

2015-01-01

Ensuring safety of young athletes and employees who perform hard physical work within the scope of their professional duties, with a special focus on prevention of a sudden cardiac death at sports fields or during hard physical work is one of the most important tasks, which demands joint effort of cardiologists and sport physicians or occupational physicians, who qualify patients for a job or a sport discipline. Apart from hypertrophic and arhythmogenic right ventricular cardiomyopathy, coronary anomalies and aortic dissection belong to the most frequent causes of dramatic complications during competitive exercise or work with an increased energy expenditure. Although a detailed medical history and a physical examination combined with 12-lead ECG assessment may significantly improve the safety in competitive sports, adding echocardiography examination gives a detailed and noninvasive insight into the heart morphology and function. Therefore, in our opinion, it should constitute a standard part of the evaluation of candidates for competitive sports. The practice indicates that beyond subjects with severe heart diseases and those classified as normal, there is a group of individuals with abnormalities which should be more closely monitored, but are not contraindications against professional sports or work with an increased energy expenditure. We describe the case of a young female with a diagnosis of rare congenital aortic valve disease, quadricuspid valve, with mild regurgitation and atrial septal aneurysm which was established during transthoracic echocardiography and confirmed and expanded during TEE examination. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

Efficacy and safety of programmable shunt valves for hydrocephalus: A meta-analysis.

PubMed

Li, Min; Wang, Han; Ouyang, Yetong; Yin, Min; Yin, Xiaoping

2017-08-01

Shunt implantation is an option in the treatment of hydrocephalus. However, the benefits and adverse effects of programmable shunt valves have not been well assessed. Randomized controlled trials (RCTs) and observational studies assessing the efficacy and safety of programmable valves (PV) treatment for hydrocephalus were identified from electronic databases (PubMed, EMBASE, and Cochrane library). The meta-analysis was performed with the fixed-effect model or random-effect model according to heterogeneity. Three RCTs and eight observational studies met the inclusion criteria including 2622 subjects. Compared with non-PV, PV treatment did not have a statistically significant effect on one-year shunt survival rate [relative risk (RR), 1.06; 95% confidence interval (CI), 0.84-1.35], Substantial heterogeneity was observed between studies (P = 0.09; I 2  = 65%). PV administration significantly reduced revision rate (RR, 0.56; 95% CI, 0.45-0.69; I 2  = 29%; P = 0.23) and over- or under-drainage complications rate (RR, 0.55; 95% CI, 0.32-0.96). PV was not associated with increased rates of other adverse events, including overall complications rate, infection rate and catheter-related complications rate. PV treatment is safe and may reduce the revision rate and over- or under-drainage complication rate, especially in patients aged less than 18 years with hydrocephalus. PV treatment is not associated with decreased overall complication rates in patients with hydrocephalus, but the trial sequential analysis indicate more studies are needed to confirm this result. Copyright © 2017. Published by Elsevier Ltd.

Clinical and hemodynamic results after direct transcatheter aortic valve replacement versus pre-implantation balloon aortic valvuloplasty: A case-matched analysis.

PubMed

Ferrera, Carlos; Nombela-Franco, Luis; Garcia, Eulogio; Jimenez-Quevedo, Pilar; Biagioni, Corina; Gonzalo, Nieves; Nuñez-Gil, Ivan; Viana-Tejedor, Ana; Salinas, Pablo; Alberto de Agustin, Jose; Almeria, Carlos; Islas, Fabian; Perez de Isla, Leopoldo; Fernandez-Perez, Cristina; Escaned, Javier; Fernández-Ortiz, Antonio; Macaya, Carlos

2017-11-01

To evaluate the safety and midterm hemodynamic results of direct transcatheter aortic valve replacement (TAVR) without pre-implantation balloon aortic valvuloplasty (BAV). BAV was considered a mandatory previous step in TAVR procedures. A total of 339 consecutive patients who underwent transfemoral TAVR were prospectively selected. A 1:1 matching was conducted, pairing age, prosthesis type (self-expandable or balloon expandable) and size, and valve calcification grade (48% with moderate to severe valve calcification). Finally, 102 pairs (102 patients with previous BAV and 102 without BAV) were obtained. Direct TAVR was feasible in all patients without any crossover to BAV group. Device success was achieved in 91.2% and 90.2% of cases in direct TAVR and pre-BAV groups (P = 0.810), respectively, without any differences in balloon postdilation rate and residual aortic regurgitation. The amount of contrast agent, acute kidney injury and myocardial injury was significantly lower in the direct implantation group (P < 0.05). No differences were found in 30-day and 1-year mortality between both groups (4.9% vs. 9.8%, P = 0.177 and 14.0% vs. 23.8%, P = 0.771, respectively). Hemodynamic parameters remained stable after 1-year follow-up in both groups. Direct transfemoral TAVR without prior BAV was safe in patients with calcified severe aortic stenosis. Pre-implantation BAV could be omitted in patients undergoing TAVR, without influence in procedure success rate, and subsequent patients' clinical course and valve hemodynamic performance. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Applicability of risk-based management and the need for risk-based economic decision analysis at hazardous waste contaminated sites.

PubMed

Khadam, Ibrahim; Kaluarachchi, Jagath J

2003-07-01

Decision analysis in subsurface contamination management is generally carried out through a traditional engineering economic viewpoint. However, new advances in human health risk assessment, namely, the probabilistic risk assessment, and the growing awareness of the importance of soft data in the decision-making process, require decision analysis methodologies that are capable of accommodating non-technical and politically biased qualitative information. In this work, we discuss the major limitations of the currently practiced decision analysis framework, which evolves around the definition of risk and cost of risk, and its poor ability to communicate risk-related information. A demonstration using a numerical example was conducted to provide insight on these limitations of the current decision analysis framework. The results from this simple ground water contamination and remediation scenario were identical to those obtained from studies carried out on existing Superfund sites, which suggests serious flaws in the current risk management framework. In order to provide a perspective on how these limitations may be avoided in future formulation of the management framework, more matured and well-accepted approaches to decision analysis in dam safety and the utility industry, where public health and public investment are of great concern, are presented and their applicability in subsurface remediation management is discussed. Finally, in light of the success of the application of risk-based decision analysis in dam safety and the utility industry, potential options for decision analysis in subsurface contamination management are discussed.

Tier-scalable reconnaissance: the challenge of sensor optimization, sensor deployment, sensor fusion, and sensor interoperability

NASA Astrophysics Data System (ADS)

Fink, Wolfgang; George, Thomas; Tarbell, Mark A.

2007-04-01

Robotic reconnaissance operations are called for in extreme environments, not only those such as space, including planetary atmospheres, surfaces, and subsurfaces, but also in potentially hazardous or inaccessible operational areas on Earth, such as mine fields, battlefield environments, enemy occupied territories, terrorist infiltrated environments, or areas that have been exposed to biochemical agents or radiation. Real time reconnaissance enables the identification and characterization of transient events. A fundamentally new mission concept for tier-scalable reconnaissance of operational areas, originated by Fink et al., is aimed at replacing the engineering and safety constrained mission designs of the past. The tier-scalable paradigm integrates multi-tier (orbit atmosphere surface/subsurface) and multi-agent (satellite UAV/blimp surface/subsurface sensing platforms) hierarchical mission architectures, introducing not only mission redundancy and safety, but also enabling and optimizing intelligent, less constrained, and distributed reconnaissance in real time. Given the mass, size, and power constraints faced by such a multi-platform approach, this is an ideal application scenario for a diverse set of MEMS sensors. To support such mission architectures, a high degree of operational autonomy is required. Essential elements of such operational autonomy are: (1) automatic mapping of an operational area from different vantage points (including vehicle health monitoring); (2) automatic feature extraction and target/region-of-interest identification within the mapped operational area; and (3) automatic target prioritization for close-up examination. These requirements imply the optimal deployment of MEMS sensors and sensor platforms, sensor fusion, and sensor interoperability.

Improved image guidance technique for minimally invasive mitral valve repair using real-time tracked 3D ultrasound

NASA Astrophysics Data System (ADS)

Rankin, Adam; Moore, John; Bainbridge, Daniel; Peters, Terry

2016-03-01

In the past ten years, numerous new surgical and interventional techniques have been developed for treating heart valve disease without the need for cardiopulmonary bypass. Heart valve repair is now being performed in a blood-filled environment, reinforcing the need for accurate and intuitive imaging techniques. Previous work has demonstrated how augmenting ultrasound with virtual representations of specific anatomical landmarks can greatly simplify interventional navigation challenges and increase patient safety. These techniques often complicate interventions by requiring additional steps taken to manually define and initialize virtual models. Furthermore, overlaying virtual elements into real-time image data can also obstruct the view of salient image information. To address these limitations, a system was developed that uses real-time volumetric ultrasound alongside magnetically tracked tools presented in an augmented virtuality environment to provide a streamlined navigation guidance platform. In phantom studies simulating a beating-heart navigation task, procedure duration and tool path metrics have achieved comparable performance to previous work in augmented virtuality techniques, and considerable improvement over standard of care ultrasound guidance.

A repositionable valved stent for endovascular treatment of deteriorated bioprostheses.

PubMed

Zegdi, Rachid; Khabbaz, Ziad; Borenstein, Nicolas; Fabiani, Jean-Noël

2006-10-03

We report our animal experience of endovascular valve replacement (VR) of failed bioprosthesis (BP) using an original delivery catheter allowing repositioning of the valved stent (VS). Among the different devices designed for percutaneous VR, none has the potential for repositioning of a fully deployed VS. Five sheep underwent, on beating heart, tricuspid VR with a stented BP. Prolapse of 1 leaflet was induced by tearing. For the endovascular tricuspid VR, we used a VS constructed with a nitinol self-expandable stent and a porcine stentless aortic valve. We also used an original delivery catheter, allowing repositioning of the VS through a compression or relaxation mechanism of the stent. Epicardial echocardiography and right ventriculography showed severe tricuspid regurgitation, with a regurgitant jet extending to the inferior vena cava. After surgical exposure to the infrarenal inferior vena cava, the VS was successfully implanted inside the failed BP in all cases. Repositioning of the fully deployed VS was always possible. Echocardiographic and macroscopic studies revealed adequate VS positioning, excellent leaflet opening, and absence of any intraprosthetic or periprosthetic leak. Endovascular VR was easily performed in sheep with failed BP in the tricuspid position. The novel delivery catheter allowed adequate repositioning of our fully deployed VS before its definitive release. One may anticipate that the safety improvement conferred by this new technology will certainly favor the development of percutaneous VR in clinical practice.

A multicentre European registry to evaluate the Direct Flow Medical transcatheter aortic valve system for the treatment of patients with severe aortic stenosis.

PubMed

Naber, Christoph K; Pyxaras, Stylianos A; Ince, Hüseyin; Frambach, Peter; Colombo, Antonio; Butter, Christian; Gatto, Fernando; Hink, Ulrich; Nickenig, Georg; Bruschi, Giuseppe; Brueren, Guus; Tchétché, Didier; Den Heijer, Peter; Schillinger, Wolfgang; Scholtz, Smita; Van der Heyden, Jan; Lefèvre, Thierry; Gilard, Martine; Kuck, Karl-Heinz; Schofer, Joachim; Divchev, Dimitar; Baumgartner, Helmut; Asch, Federico; Wagner, Daniel; Latib, Azeem; De Marco, Federico; Kische, Stephan

2016-12-10

Our aim was to assess the clinical outcomes of the Direct Flow Medical Transcatheter Aortic Valve System (DFM-TAVS), when used in routine clinical practice. This is a prospective, open-label, multicentre, post-market registry of patients treated with DFM-TAVS according to approved commercial indications. Echocardiographic and angiographic data were evaluated by an independent core laboratory and adverse events were adjudicated and classified according to VARC-2 criteria by an independent clinical events committee. The primary endpoint was freedom from all-cause mortality at 30 days post procedure. Secondary endpoints included procedural, early safety and efficacy endpoints at 30 days. Two hundred and fifty patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) with the DFM-TAVS were enrolled in 21 European centres. The primary endpoint, freedom from all-cause mortality at 30 days, was met in 98% (245/250) of patients. Device success was 83.8%. Moderate or severe aortic regurgitation was reported in 3% of patients, and none/trace regurgitation in 73% of patients. Post-procedural permanent pacemaker implantation was performed in 30 patients (12.0%). The DFM-TAVS was associated with good short-term outcomes in this real-world registry. The low pacemaker and aortic regurgitation rates confirm the advantages of this next-generation transcatheter heart valve (THV).

National Dam Safety Program. Lake Sonoma Dam (NJ 0193), Passaic River Basin, Branch of Burnt Meadow Brook, Passaic County, New Jersey. Phase I Inspection Report.

DTIC Science & Technology

1980-03-01

iron pipe through the dam approximately 42 feet right of the spillway. The flow through the pipe is controlled by a manually operated gate valve located...NATIONAL DAM SAFETY PROGRAM. LAKE SONOMA DAM (NJ 0193). PASSAIC-ETC(U) MAR 80 J P TALERICO DACW MI-T9-C-0011 UNCLASSIFIED NLmhhIEIIIEEEEEI...IIIIIIIIIIEEEE EIIIEEEEEIIEI IIIIEEEEEEEEEE PASS~AIC RIVER BASIN BRANCH OF BURNT MEADOW BROOK PASSAIC COUNTY, NEW JERSEY LA0 O0IM DAM NJi 00193 PHASE 1 INPCTO

78 FR 7458 - Petitions for Modification of Application of Existing Mandatory Safety Standards

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-01

.... Petitioner: Sterling Mining Corporation, P.O. Box 217, North Lima, Ohio 44452. Mines: Shean Hill, MSHA I.D... outlets and valves. 6. Due to the thin coal seam and low mining height, the pipes placed along the roof... Granules (Ione) LLC, 1101 Opal Court, Suite 315, Hagerstown, Maryland 21740. Mine: Ione Mine, MSHA I.D. No...

46 CFR 54.15-15 - Relief devices for unfired steam boilers, evaporators, and heat exchangers (modifies UG-126).

Code of Federal Regulations, 2013 CFR

2013-10-01

..., and heat exchangers (modifies UG-126). 54.15-15 Section 54.15-15 Shipping COAST GUARD, DEPARTMENT OF... devices for unfired steam boilers, evaporators, and heat exchangers (modifies UG-126). (a) An approved... more than 6 percent above the safety valve setting. (f) A heat exchanger with liquid in the shell and...

46 CFR 54.15-15 - Relief devices for unfired steam boilers, evaporators, and heat exchangers (modifies UG-126).

Code of Federal Regulations, 2014 CFR

2014-10-01

..., and heat exchangers (modifies UG-126). 54.15-15 Section 54.15-15 Shipping COAST GUARD, DEPARTMENT OF... devices for unfired steam boilers, evaporators, and heat exchangers (modifies UG-126). (a) An approved... more than 6 percent above the safety valve setting. (f) A heat exchanger with liquid in the shell and...