Onboard Inert Gas Generation System/Onboard Oxygen Gas Generation System (OBIGGS/OBOGS) Study. Part 1; Aircraft System Requirements

NASA Technical Reports Server (NTRS)

Reynolds, Thomas L.; Bailey, Delbert B.; Lewinski, Daniel F.; Roseburg, Conrad M.; Palaszewski, Bryan (Technical Monitor)

2001-01-01

The purpose of this technology assessment is to define a multiphase research study program investigating Onboard Inert Gas Generation Systems (OBIGGS) and Onboard Oxygen Generation Systems (OBOGS) that would identify current airplane systems design and certification requirements (Subtask 1); explore state-of-the-art technology (Subtask 2); develop systems specifications (Subtask 3); and develop an initial system design (Subtask 4). If feasible, consideration may be given to the development of a prototype laboratory test system that could potentially be used in commercial transport aircraft (Subtask 5). These systems should be capable of providing inert nitrogen gas for improved fire cargo compartment fire suppression and fuel tank inerting and emergency oxygen for crew and passenger use. Subtask I of this research study, presented herein, defines current production aircraft certification requirements and design objectives necessary to meet mandatory FAA certification requirements and Boeing design and performance specifications. These requirements will be utilized for baseline comparisons for subsequent OBIGGS/OBOGS application evaluations and assessments.

A Novel Therapy for Inflammatory Bowel Disease-Dual Regulatory T-Cell Programming

DTIC Science & Technology

2017-08-01

Subtask 1: to determine 1,25(OH)2D concentration by ELISA in the dLNs following subcutaneous infusion of the different DCs. 1-3 Subtask 2: to...Achieved: 1. Subtask-1: In one experiment, we failed to detect a significant amount of 1,25(OH)2D by ELISA in the dLNs following subcutaneous...injections of the different DCs. Potential reasons include: 1) the ELISA method was not sufficiently sensitive; 2) we had a problem extracting the

INVESTIGATING ENVIRONMENTAL SINKS OF MACROLIDE ...

EPA Pesticide Factsheets

Possible environmental sinks (wastewater effluents, biosolids, sediments) of macrolide antibiotics (i.e., azithromycin, roxithromycin and clarithromycin)are investigated using state-of-the-art analytical chemistry techniques. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews

Enhanced oil recovery utilizing high-angle wells in the Frontier Formation, Badger Basin Field, Park County, Wyoming. Quarterly technical progress report, 1 October 1993--31 December 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fortmann, R.G.

1994-01-14

The goals during this period included the following objectives from the Statement of Work: in Phase 2A, completion of Subtask 2.1.4 -- Interpret data, of Task 2.1 -- Acquire 3-D seismic data; and, in Phase 2B, completion of Subtask 2.2.1 -- Solicit bids and award, and initiation of Subtask 2.2.2 -- Acquire cores, of Task 2.2 -- Drill slant hole. Subtask 2.1.4 -- Interpret data: Interpretation of the 3- D seismic survey was completed on a Sun Sparcstation10 workstation (UNIX based), using Landmark Graphics latest version of Seisworks 3D software. Subtask 2.2.2 -- Acquire cores: Sierra had picked a locationmore » and prepared a drilling plan for the slant/horizontal wellbores. Sierra was ready to submit an Application for Permit to Drill. However, due to the fact that Sierra entered into an agreement to sell the Badger Basin property, the drilling phase was put on hold.« less

Orbit transfer rocket engine integrated control and health monitoring system technology readiness assessment

NASA Technical Reports Server (NTRS)

Bickford, R. L.; Collamore, F. N.; Gage, M. L.; Morgan, D. B.; Thomas, E. R.

1992-01-01

The objectives of this task were to: (1) estimate the technology readiness of an integrated control and health monitoring (ICHM) system for the Aerojet 7500 lbF Orbit Transfer Vehicle engine preliminary design assuming space based operations; and (2) estimate the remaining cost to advance this technology to a NASA defined 'readiness level 6' by 1996 wherein the technology has been demonstrated with a system validation model in a simulated environment. The work was accomplished through the conduct of four subtasks. In subtask 1 the minimally required functions for the control and monitoring system was specified. The elements required to perform these functions were specified in Subtask 2. In Subtask 3, the technology readiness level of each element was assessed. Finally, in Subtask 4, the development cost and schedule requirements were estimated for bringing each element to 'readiness level 6'.

Beam and Plasma Physics Research

DTIC Science & Technology

1990-06-01

La di~raDy in high power microwave computations and thi-ory and high energy plasma computations and theory. The HPM computations concentrated on...2.1 REPORT INDEX 7 2.2 TASK AREA 2: HIGH-POWER RF EMISSION AND CHARGED- PARTICLE BEAM PHYSICS COMPUTATION , MODELING AND THEORY 10 2.2.1 Subtask 02-01...Vulnerability of Space Assets 22 2.2.6 Subtask 02-06, Microwave Computer Program Enhancements 22 2.2.7 Subtask 02-07, High-Power Microwave Transvertron Design 23

Targeting a Novel Androgen Receptor-Repressed Pathway in Prostate Cancer Therapy

DTIC Science & Technology

2017-09-01

AURKA and CENPE. [ Study is on - going] Major Task 3: Test the hypothesis that androgen deprivation-induced PKD1 expression. Major Task 4: Test the...Subtask 3: Conduct detail analysis of the pathway identified in Subtask 2 and assessing its impact on PKD1 expression. This study is on -going. We...enzalutamide, in androgen-sensitivity PrCa cells. We have completed this subtask. In this study , although PKD2 overexpression had little impact on LNCaP

An informal analysis of flight control tasks

NASA Technical Reports Server (NTRS)

Andersen, George J.

1991-01-01

Issues important in rotorcraft flight control are discussed. A perceptual description is suggested of what is believed to be the major issues in flight control. When the task is considered of a pilot controlling a helicopter in flight, the task is decomposed in several subtasks. These subtasks include: (1) the control of altitude, (2) the control of speed, (3) the control of heading, (4) the control of orientation, (5) the control of flight over obstacles, and (6) the control of flight to specified positions in the world. The first four subtasks can be considered to be primary control tasks as they are not dependent on any other subtasks. However, the latter two subtasks can be considered hierarchical tasks as they are dependent on other subtasks. For example, the task of flight control over obstacles can be decomposed as a task requiring the control of speed, altitude, and heading. Thus, incorrect control of altitude should result in poor control of flight over an obstacle.

FATE OF SYNTHETIC MUSK COMPOUNDS IN AN AQUATIC ...

EPA Pesticide Factsheets

To be presented is an overview of the chemistry, the monitoring methodology, and the statistical evaluation of concentrations obtained from the analysis of a suite of these compounds (e.g., Galaxolide®, musk xylene, and amino musk xylene) in different environmental compartments. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations,

LEVELS OF SYNTHETIC MUSK COMPOUNDS IN ...

EPA Pesticide Factsheets

To be presented is an overview of the chemistry, the monitoring methodology, and the statistical evaluation of concentrations obtained from the analysis of a suite of compounds (e.g., Galaxolide®, musk xylene, and amino musk xylene) in an aquatic ecological site. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles

Studies of Coronae and Large Volcanoes on Venus: Constraining the Diverse Outcomes of Small-Scale Mantle Upwellings on Venus

NASA Technical Reports Server (NTRS)

Stofan, Ellen R.

2005-01-01

Proxemy Research had a grant from NASA to perform science research on upwelling and volcanism on Venus. This was a 3 year Planetary Geology and Geophysics grant to E. Stofan, entitled Coronae and Large volcanoes on Venus. This grant closes on 12/31/05. Here we summarize the scientific progress and accomplishments of this grant. Scientific publications and abstracts of presentations are indicated in the final section. This was a very productive grant and the progress that was made is summarized. Attention is drawn to the publications and abstracts published in each year. The proposal consisted of two tasks, one examining coronae and one studying large volcanoes. The corona task (Task 1) consisted of three parts: 1) a statistical study of the updated corona population, with Sue Smrekar, Lori Glaze, Paula Martin and Steve Baloga; 2) geologic analysis of several specific groups of coronae, with Sue Smrekar and others; and 3) determining the histories and significance of a number of coronae with extreme amounts of volcanism, with Sue Smrekar. Task 2, studies of large volcanoes, consisted of two subtasks. In the first, we studied the geologic history of several volcanoes, with John Guest, Peter Grindrod, Antony Brian and Steve Anderson. In the second subtask, I analyzed a number of Venusian volcanoes with evidence of summit diking along with Peter Grindrod and Francis Nimmo.

Detection of Brain Reorganization in Pediatric Multiple Sclerosis Using Functional MRI

DTIC Science & Technology

2015-10-01

accomplish this, we apply comparative assessments of fMRI mappings of language, memory , and motor function, and performance on clinical neurocognitive...community at a target rate of 13 volunteers per quarter period; acquire fMRI data for language, memory , and visual-motor functions (months 3-12). c...consensus fMRI activation maps for language, memory , and visual-motor tasks (months 8-12). f) Subtask 1f. Prepare publication to disseminate our

Strategic adaptation to performance objectives in a dual-task setting.

PubMed

Janssen, Christian P; Brumby, Duncan P

2010-11-01

How do people interleave attention when multitasking? One dominant account is that the completion of a subtask serves as a cue to switch tasks. But what happens if switching solely at subtask boundaries led to poor performance? We report a study in which participants manually dialed a UK-style telephone number while driving a simulated vehicle. If the driver were to exclusively return his or her attention to driving after completing a subtask (i.e., using the single break in the xxxxx-xxxxxx representational structure of the number), then we would expect to see a relatively poor driving performance. In contrast, our results show that drivers choose to return attention to steering control before the natural subtask boundary. A computational modeling analysis shows that drivers had to adopt this strategy to meet the required performance objective of maintaining an acceptable lateral position in the road while dialing. Taken together these results support the idea that people can strategically control the allocation of attention in multitask settings to meet specific performance criteria. Copyright © 2010 Cognitive Science Society, Inc.

Transcranial direct current stimulation facilitates cognitive multi-task performance differentially depending on anode location and subtask

PubMed Central

Scheldrup, Melissa; Greenwood, Pamela M.; McKendrick, Ryan; Strohl, Jon; Bikson, Marom; Alam, Mahtab; McKinley, R. Andy; Parasuraman, Raja

2014-01-01

There is a need to facilitate acquisition of real world cognitive multi-tasks that require long periods of training (e.g., air traffic control, intelligence analysis, medicine). Non-invasive brain stimulation—specifically transcranial Direct Current Stimulation (tDCS)—has promise as a method to speed multi-task training. We hypothesized that during acquisition of the complex multi-task Space Fortress, subtasks that require focused attention on ship control would benefit from tDCS aimed at the dorsal attention network while subtasks that require redirection of attention would benefit from tDCS aimed at the right hemisphere ventral attention network. We compared effects of 30 min prefrontal and parietal stimulation to right and left hemispheres on subtask performance during the first 45 min of training. The strongest effects both overall and for ship flying (control and velocity subtasks) were seen with a right parietal (C4, reference to left shoulder) montage, shown by modeling to induce an electric field that includes nodes in both dorsal and ventral attention networks. This is consistent with the re-orienting hypothesis that the ventral attention network is activated along with the dorsal attention network if a new, task-relevant event occurs while visuospatial attention is focused (Corbetta et al., 2008). No effects were seen with anodes over sites that stimulated only dorsal (C3) or only ventral (F10) attention networks. The speed subtask (update memory for symbols) benefited from an F9 anode over left prefrontal cortex. These results argue for development of tDCS as a training aid in real world settings where multi-tasking is critical. PMID:25249958

Transcranial direct current stimulation facilitates cognitive multi-task performance differentially depending on anode location and subtask.

PubMed

Scheldrup, Melissa; Greenwood, Pamela M; McKendrick, Ryan; Strohl, Jon; Bikson, Marom; Alam, Mahtab; McKinley, R Andy; Parasuraman, Raja

2014-01-01

There is a need to facilitate acquisition of real world cognitive multi-tasks that require long periods of training (e.g., air traffic control, intelligence analysis, medicine). Non-invasive brain stimulation-specifically transcranial Direct Current Stimulation (tDCS)-has promise as a method to speed multi-task training. We hypothesized that during acquisition of the complex multi-task Space Fortress, subtasks that require focused attention on ship control would benefit from tDCS aimed at the dorsal attention network while subtasks that require redirection of attention would benefit from tDCS aimed at the right hemisphere ventral attention network. We compared effects of 30 min prefrontal and parietal stimulation to right and left hemispheres on subtask performance during the first 45 min of training. The strongest effects both overall and for ship flying (control and velocity subtasks) were seen with a right parietal (C4, reference to left shoulder) montage, shown by modeling to induce an electric field that includes nodes in both dorsal and ventral attention networks. This is consistent with the re-orienting hypothesis that the ventral attention network is activated along with the dorsal attention network if a new, task-relevant event occurs while visuospatial attention is focused (Corbetta et al., 2008). No effects were seen with anodes over sites that stimulated only dorsal (C3) or only ventral (F10) attention networks. The speed subtask (update memory for symbols) benefited from an F9 anode over left prefrontal cortex. These results argue for development of tDCS as a training aid in real world settings where multi-tasking is critical.

A Response Surface Methodology for Bi-Level Integrated System Synthesis (BLISS)

NASA Technical Reports Server (NTRS)

Altus, Troy David; Sobieski, Jaroslaw (Technical Monitor)

2002-01-01

The report describes a new method for optimization of engineering systems such as aerospace vehicles whose design must harmonize a number of subsystems and various physical phenomena, each represented by a separate computer code, e.g., aerodynamics, structures, propulsion, performance, etc. To represent the system internal couplings, the codes receive output from other codes as part of their inputs. The system analysis and optimization task is decomposed into subtasks that can be executed concurrently, each subtask conducted using local state and design variables and holding constant a set of the system-level design variables. The subtasks results are stored in form of the Response Surfaces (RS) fitted in the space of the system-level variables to be used as the subtask surrogates in a system-level optimization whose purpose is to optimize the system objective(s) and to reconcile the system internal couplings. By virtue of decomposition and execution concurrency, the method enables a broad workfront in organization of an engineering project involving a number of specialty groups that might be geographically dispersed, and it exploits the contemporary computing technology of massively concurrent and distributed processing. The report includes a demonstration test case of supersonic business jet design.

Useful field of view test performance throughout adulthood in subjects without ocular disorders.

PubMed

Woutersen, Karlijn; van den Berg, Albert V; Boonstra, F Nienke; Theelen, Thomas; Goossens, Jeroen

2018-01-01

Previous research has shown an age-related decline in Useful Field of View (UFOV) test performance, which measures the duration required to extract relevant information from a scene in three subtasks. However, these results are mostly based on data that may have been confounded by (age-related) ocular diseases. We examined UFOV performance in subjects aged 19.5 to 70.3 years to investigate how UFOV performance changes throughout adulthood. All subjects underwent a thorough ophthalmological examination to exclude ocular disorders. We also examined some elementary visual functions, i.e., near and far visual acuity, crowding and contrast sensitivity. We investigated whether these functions were related to age and whether they could explain a possible age-related decline in UFOV performance. The subjects (n = 41) performed very well on almost every measure and reached far better UFOV and visual acuity scores than those reported by other studies that relied on self-reported absence of ocular pathology. We did not find significant relationships between age and any of the elementary visual functions or the first two UFOV subtasks (R2UFOV1 = 0.03, p = 0.25; R2UFOV2 = 0.07, p = 0.10). However, we found an age-related decline in performance on the third UFOV subtask (R2UFOV3 = 0.36, p < 0.001), which was unrelated to performance on the elementary visual function tasks. Our results show that performance on the first two UFOV subtasks as well as central elementary visual functions may remain high in the absence of obvious ophthalmological pathology.

Hierarchical Bayesian Models of Subtask Learning

ERIC Educational Resources Information Center

Anglim, Jeromy; Wynton, Sarah K. A.

2015-01-01

The current study used Bayesian hierarchical methods to challenge and extend previous work on subtask learning consistency. A general model of individual-level subtask learning was proposed focusing on power and exponential functions with constraints to test for inconsistency. To study subtask learning, we developed a novel computer-based booking…

Rapid Response Research and Development (R&D) for the Aerospace Systems Directorate. Delivery Order 0021: Engineering Research and Technical Analyses of Advanced Airbreathing Propulsion Fuels, Subtask: Engine and Pump Studies Utilizing JP-8 and Alcohol-to-Jet (ATJ) Blends

DTIC Science & Technology

2014-08-01

41 Figure A-21. Lubricant Soot Accumulation...ASTM D4739 Total Base Number ASTM D664 Total Acid Number ASTM D445 Kinematic Viscosity @ 100°C ASTM D4052 Density ASTM TGA SOOT TGA Soot ASTM E168...118.85 134.01 145.47 169.22 187.43 342.42 Nitration (Abs./cm) E168 FTIR 0 6.67 10.91 16.54 19.04 25.79 35.12 24.03 23.75 52.31 93.9 Soot (%) Soot TGA

Differences in Multitask Resource Reallocation After Change in Task Values.

PubMed

Matton, Nadine; Paubel, Pierre; Cegarra, Julien; Raufaste, Eric

2016-12-01

The objective was to characterize multitask resource reallocation strategies when managing subtasks with various assigned values. When solving a resource conflict in multitasking, Salvucci and Taatgen predict a globally rational strategy will be followed that favors the most urgent subtask and optimizes global performance. However, Katidioti and Taatgen identified a locally rational strategy that optimizes only a subcomponent of the whole task, leading to detrimental consequences on global performance. Moreover, the question remains open whether expertise would have an impact on the choice of the strategy. We adopted a multitask environment used for pilot selection with a change in emphasis on two out of four subtasks while all subtasks had to be maintained over a minimum performance. A laboratory eye-tracking study contrasted 20 recently selected pilot students considered as experienced with this task and 15 university students considered as novices. When two subtasks were emphasized, novices focused their resources particularly on one high-value subtask and failed to prevent both low-value subtasks falling below minimum performance. On the contrary, experienced people delayed the processing of one low-value subtask but managed to optimize global performance. In a multitasking environment where some subtasks are emphasized, novices follow a locally rational strategy whereas experienced participants follow a globally rational strategy. During complex training, trainees are only able to adjust their resource allocation strategy to subtask emphasis changes once they are familiar with the multitasking environment. © 2016, Human Factors and Ergonomics Society.

Fluctuations in work motivation: tasks do not matter!

PubMed

Navarro, Jose; Curioso, Fernando; Gomes, Duarte; Arrieta, Carlos; Cortes, Mauricio

2013-01-01

Previous studies have shown that work motivation fluctuates considerably and in a nonlinear way over time. In the present research, we are interested in studying if the task at hand does or does not influence the presence of these fluctuations. We gathered daily registers from 69 workers during 21 consecutive working days (7036 registers) of task developed and levels of motivation, self-efficacy beliefs and instrumentalities perception. These registers were then categorized into a list of labor activities in main tasks and subtasks by means of three judges with a high level of agreement (97.47% for tasks, and 98.64% for subtasks). Taking the MSSD statistic (mean squared successive difference) of the average of motivation, self-efficacy and instrumentality, and using hierarchical regression analysis we have found that tasks (beta = .03; p = .188) and subtasks (beta = .10; p = .268) do not affect the presence of fluctuations in motivation. These results reveal instability in work motivation independently from the tasks and subtasks that the workers do. We proceed to find that fluctuations in work motivation show a fractal structure across the different tasks we do in a working day. Implications of these results to motivational theory will be discussed as well as possible explanations (e.g. the influence of affect in work motivation) and directions for future research are provided.

Developing Novel Therapeutic Approaches in Small Cell Lung Carcinoma Using Genetically Engineered Mouse Models and Human Circulating Tumor Cells

DTIC Science & Technology

2015-10-01

xenograft models . 12-36 Dr. Engelman Subtask 3: Analyze CTCs for P-4EBP1, P-S6, BIM , Bcl-2, Bcl-xL, and Mcl-1 using ISH and IHC We propose...Using Genetically Engineered Mouse Models and Human Circulating Tumor Cells PRINCIPAL INVESTIGATOR: Jeffrey Engelman MD PhD CONTRACTING...reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions

Chemical Library Screening for Potential Therapeutics Using Novel Cell Based Models of ALS

DTIC Science & Technology

2017-06-01

Major Task 1, Subtask 1. Our first major activity in year 1 was the design and engineering of a custom inducible plasmid for expressing fluorescently...back to that construct. Other achievements during this first major activity derived from investigating why Broccoli RNA aptamer did not fold...These are outlined below in the CHANGES/PROBLEMS section. Major Task 1, Subtask 2. Our second major activity in year 1 was to generate human neural

Methods, apparatus and system for selective duplication of subtasks

DOEpatents

Andrade Costa, Carlos H.; Cher, Chen-Yong; Park, Yoonho; Rosenburg, Bryan S.; Ryu, Kyung D.

2016-03-29

A method for selective duplication of subtasks in a high-performance computing system includes: monitoring a health status of one or more nodes in a high-performance computing system, where one or more subtasks of a parallel task execute on the one or more nodes; identifying one or more nodes as having a likelihood of failure which exceeds a first prescribed threshold; selectively duplicating the one or more subtasks that execute on the one or more nodes having a likelihood of failure which exceeds the first prescribed threshold; and notifying a messaging library that one or more subtasks were duplicated.

The Effect of Guided Imagery and Internal Visualization on Learning

DTIC Science & Technology

1987-01-01

existance) of - . memory traces, and how retrival cues operate, to name a few. The lack of a single theory or a coherent approach has not deterred movement...and function (Subtask 3) to a 31% gain over the control group for information emphasizing the rote memory of sequential data (Subtask 1). Overall, the

Orbit transfer rocket engine technology program: Advanced engine study

NASA Technical Reports Server (NTRS)

Erickson, C. M.

1992-01-01

In Task D.6 of the Advanced Engine Study, three primary subtasks were accomplished: (1) design of parametric data; (2) engine requirement variation studies; and (3) vehicle study/engine study coordination. Parametric data were generated for vacuum thrusts ranging from 7500 lbf to 50,000 lbf, nozzle expansion ratios from 600 to 1200, and engine mixture ratios from 5:1 to 7:1. Failure Modes and Effects Analysis (FMEA) was used as a departure point for these parametric analyses. These data are intended to assist in definition and trade studies. In the Engine Requirements Variation Studies, the individual effects of increasing the throttling ratio from 10:1 to 20:1 and requiring the engine to operate at a maximum mixture ratio of 12:1 were determined. Off design engine balances were generated at these extreme conditions and individual component operating requirements analyzed in detail. Potential problems were identified and possible solutions generated. In the Vehicle Study/Engine Study coordination subtask, vehicle contractor support was provided as needed, addressing a variety of issues uncovered during vehicle trade studies. This support was primarily provided during Technical Interchange Meetings (TIM) in which Space Exploration Initiative (SEI) studies were addressed.

Enhancing Propriospinal Relays to Improve Functional Recovery After SCI

DTIC Science & Technology

2017-10-01

injury to the spinal cord. We have completed experiments for subtask 1 – 4 of specific aim 1 and subtasks 1 for specific aim 2. This Aim 2 of the...previously observed PAP2 to induce robust regeneration in a dorsal hemisection model and thought it might enhance regeneration and sprouting after the more...spontaneous recovery is often observed after incomplete injuries, leading to partial recovery over time. Spontaneous recovery is thought to be

Aerospace engineering design by systematic decomposition and multilevel optimization

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, J.; Barthelemy, J. F. M.; Giles, G. L.

1984-01-01

A method for systematic analysis and optimization of large engineering systems, by decomposition of a large task into a set of smaller subtasks that is solved concurrently is described. The subtasks may be arranged in hierarchical levels. Analyses are carried out in each subtask using inputs received from other subtasks, and are followed by optimizations carried out from the bottom up. Each optimization at the lower levels is augmented by analysis of its sensitivity to the inputs received from other subtasks to account for the couplings among the subtasks in a formal manner. The analysis and optimization operations alternate iteratively until they converge to a system design whose performance is maximized with all constraints satisfied. The method, which is still under development, is tentatively validated by test cases in structural applications and an aircraft configuration optimization.

Performance of Different Timed Up and Go Subtasks in Frailty Syndrome.

PubMed

Ansai, Juliana Hotta; Farche, Ana Claudia Silva; Rossi, Paulo Giusti; de Andrade, Larissa Pires; Nakagawa, Theresa Helissa; Takahashi, Anielle Cristhine de Medeiros

2017-11-28

Gait speed, mobility, and postural transitions should be taken into account in older adults with frailty syndrome and can be assessed by the Timed Up and Go (TUG) Test. However, it is unclear which TUG subtasks have greater influence in identifying frail people and whether prefrail individuals present with any reduced subtask performance. The objective of this study was to investigate the differences in performance of TUG subtasks between frail, prefrail, and nonfrail older adults. A cross-sectional study was performed with community-dwelling older adults, including 43 nonfrail, 30 prefrail, and 7 frail individuals. The TUG subtasks (sit-to-stand, walking forward, turning, walking back, and turn-to-sit) were assessed using a Qualisys motion system. Data were captured by Qualisys Track Manager software and processed by Visual 3D software. The Matlab program was used to detect, separate, and analyze the TUG subtasks. Statistical significance was set at α = .05 and SigmaPlot software (11.0) was used. The total time to complete the TUG was significantly longer among frail participants than among those who were prefrail and nonfrail. Statistically significant differences in temporal parameters in the turning, walking forward, and walking back subtasks between nonfrail/prefrail and frail older people were found. In addition, the transition TUG subtasks (average and peak velocities of the trunk) distinguished the frail group from the other groups, demonstrating altered quality of movement. The findings support the value of analyzing the TUG subtasks to improve understanding of mobility impairment in frailty syndrome.

Episodic-like memory trace in awake replay of hippocampal place cell activity sequences

PubMed Central

Takahashi, Susumu

2015-01-01

Episodic memory retrieval of events at a specific place and time is effective for future planning. Sequential reactivation of the hippocampal place cells along familiar paths while the animal pauses is well suited to such a memory retrieval process. It is, however, unknown whether this awake replay represents events occurring along the path. Using a subtask switching protocol in which the animal experienced three subtasks as ‘what’ information in a maze, I here show that the replay represents a trial type, consisting of path and subtask, in terms of neuronal firing timings and rates. The actual trial type to be rewarded could only be reliably predicted from replays that occurred at the decision point. This trial-type representation implies that not only ‘where and when’ but also ‘what’ information is contained in the replay. This result supports the view that awake replay is an episodic-like memory retrieval process. DOI: http://dx.doi.org/10.7554/eLife.08105.001 PMID:26481131

Early Detection of NSCLC Using Stromal Markers in Peripheral Blood

DTIC Science & Technology

2016-09-01

circulating myeloid cells, flow cytometry, RNA -sequencing, expression profiling. 3. ACCOMPLISHMENTS:  What were the major goals of the project...Subtask 2: Flow cytometry sorting of circulating myeloid cells. Subtask 3: RNA -Sequencing Subtask 4: RNA -seq data analysis Subtask 5: Feasible RT-PCR...accomplished the patient recruitment, flow cytometry sorting of circulating myeloid cells, RNA -sequencing of the samples. During the RNA - seq data analysis, we

Chemical Compatibility of High-Tc Superconductors with Other Materials

DTIC Science & Technology

1988-07-22

OFFICE OF NAVAL RESEARCH oil fit Research Contract N00014-87-K-0014 R&T Code 413E26---01 0 Technical Report No. 12 0)" CHEMICAL COMPATIBILITY OF...Center University of California, Los Angeles, CA 90024-1569 In Press ’, in Z- "Physical Chemistry of High -Temperature Superc ,nductorx" D.L. Nelson and...1 flTERTALS4 12 PERSONAL AUTHOR(S .. (ilasai~ 113a TYPE Of REPORT I13b TIME COVERED 14 DATE OF REPORT (Year,PMonth, Day) S PAGE COUNT _Tehia Prpit__AI

SUBTASK 6.1 – STRATEGIC STUDIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erickson, Thomas; Harju, John; Steadman, Edward

The Energy & Environmental Research Center (EERC) has recently completed 7 years of research through the Cooperative Agreement with the U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL) focused on fossil energy technology development and demonstration. To support a significant number of the different activities being considered within all of our research contracts with NETL, a subtask (6.1 – Strategic Studies) was created to focus on small research efforts that came up throughout the year that would support an existing EERC–NETL project or would help to develop a new concept for inclusion in future efforts. This subtask wasmore » funded through the EERC–DOE Joint Program on Research and Development for Fossil Energy-Related Resources Cooperative Agreement No. DE-FC26- 08NT43291« less

The National Shipbuilding Research Program. Environmental Studies and Testing (Phase V)

DTIC Science & Technology

2000-11-20

development of an analytical procedure for toxic organic compounds, including TBT ( tributyltin ), whose turnaround time would be in the order of minutes...Cost of the Subtask was $20,000. Subtask #33 - Turnaround Analytical Method for TBT This Subtask performed a preliminary investigation leading to the...34Quick TBT Analytical Method" that will yield reliable results in 15 minutes, a veritable breakthrough in sampling technology. The Subtask was managed by

Human Factors Engineering. Student Supplement,

DTIC Science & Technology

1981-08-01

a job TASK TAXONOMY A classification scheme for the different levels of activities in a system, i.e., job - task - sub-task, etc. TASK-AN~ALYSIS...with the classification of learning objectives by learning category so as to identify learningPhas III guidelines necessary for optimum learning to...correct. .4... .the sequencing of all dependent tasks. .1.. .the classification of learning objectives by learning category and the Identification of

Naturalistic Assessment of Everyday Functioning in Individuals with Mild Cognitive Impairment: The Day Out Task

PubMed Central

Schmitter-Edgecombe, Maureen; McAlister, Courtney; Weakley, Alyssa

2012-01-01

Objective The Day Out Task (DOT), a naturalistic task that requires multitasking in a real-world setting, was used to examine everyday functioning in individuals with mild cognitive impairment (MCI). Method Thirty-eight participants with MCI and 38 cognitively healthy older adult controls prioritized, organized, initiated and completed a number of subtasks in a campus apartment to prepare for a day out (e.g., determine and gather change for bus, bring a magazine). Participants also completed tests assessing cognitive constructs important in multitasking (i.e., retrospective memory, prospective memory, planning). Results Compared to controls, the MCI group required more time to complete the DOT and demonstrated poorer task accuracy, performing more subtasks incompletely and inaccurately. Despite poorer DOT task accuracy, the MCI and control groups approached completion of the DOT in a similar manner. For the MCI group, retrospective memory was a unique predictor of the number of subtasks left incomplete and inaccurate, while prospective memory was a unique predictor of DOT sequencing. The DOT measures, but not the cognitive tests, were predictive of knowledgeable informant report of everyday functioning. Conclusions These findings suggest that difficulty remembering and keeping track of multiple goals and subgoals may contribute to the poorer performance of individuals with MCI in complex everyday situations. PMID:22846035

INTRODUCTION TO PHARMACEUTICALS AND PERSONAL ...

EPA Pesticide Factsheets

There is no abstract for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. Subtask 3: T

PHARMACEUTICALS AND PERSONAL CARE PRODUCTS ...

EPA Pesticide Factsheets

There is no abstract for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. Subtask 3: T

MONITORING SYNTHETIC MUSK COMPOUNDS IN ...

EPA Pesticide Factsheets

Synthetic musk compounds are manufactured as fragrance materials for consumer products and are consumed in very large quantities worldwide. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. Subtask 3: To apply state-of-the-art envir

CORRELATION OF CHEMICAL MARKERS - NITRATE AND ...

EPA Pesticide Factsheets

Giving public water authorities another tool to monitor and measure levels of human waste contamination of waters simply and rapidly would enhance public protection. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. Subtask 3: To ap

Energy-Efficient Scheduling for Hybrid Tasks in Control Devices for the Internet of Things

PubMed Central

Gao, Zhigang; Wu, Yifan; Dai, Guojun; Xia, Haixia

2012-01-01

In control devices for the Internet of Things (IoT), energy is one of the critical restriction factors. Dynamic voltage scaling (DVS) has been proved to be an effective method for reducing the energy consumption of processors. This paper proposes an energy-efficient scheduling algorithm for IoT control devices with hard real-time control tasks (HRCTs) and soft real-time tasks (SRTs). The main contribution of this paper includes two parts. First, it builds the Hybrid tasks with multi-subtasks of different function Weight (HoW) task model for IoT control devices. HoW describes the structure of HRCTs and SRTs, and their properties, e.g., deadlines, execution time, preemption properties, and energy-saving goals, etc. Second, it presents the Hybrid Tasks' Dynamic Voltage Scaling (HTDVS) algorithm. HTDVS first sets the slowdown factors of subtasks while meeting the different real-time requirements of HRCTs and SRTs, and then dynamically reclaims, reserves, and reuses the slack time of the subtasks to meet their ideal energy-saving goals. Experimental results show HTDVS can reduce energy consumption about 10%–80% while meeting the real-time requirements of HRCTs, HRCTs help to reduce the deadline miss ratio (DMR) of systems, and HTDVS has comparable performance with the greedy algorithm and is more favorable to keep the subtasks' ideal speeds. PMID:23112659

PRESENTATION--PPCPS: OVERVIEW OF SOURCES ...

EPA Pesticide Factsheets

This presentation briefly summarizes some of what is known and not known about the occurrence of drugs in the environment, the potential for chronic effects on wildlife (and some instances of acute effects), the relevance of drug residues in drinking water to consumer risk perception, and actions that can be taken to reduce environmental exposure. Efforts are underway at U.S. federal agencies such as the USGS, FDA, USDA, NOAA, NIEHS, and the CDC, as well as the EPA. This work is beginning to be coordinated under an Interagency Task Group (PiE: Pharmaceuticals in the Environment), which was chartered under a subcommittee of OSTP's (National Science and Technology Council) Committee on Environment and Natural Resources (http://www.ostp.gov/NSTC/html/committee/cenr.html). The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analy

PPCPS: OVERVIEW OF SOURCES, ENVIRONMENTAL ...

EPA Pesticide Factsheets

This presentation briefly summarizes some of what is known and not known about the occurrence of drugs in the environment, the potential for chronic effects on wildlife (and some instances of acute effects), the relevance of drug residues in drinking water to consumer risk perception, and actions that can be taken to reduce environmental exposure. Efforts are underway at U.S. federal agencies such as the USGS, FDA, USDA, NOAA, NIEHS, and the CDC, as well as the EPA. This work is beginning to be coordinated under an Interagency Task Group (PiE: Pharmaceuticals in the Environment), which was chartered under a subcommittee of OSTP¿s (National Science and Technology Council) Committee on Environment and Natural Resources (http://www.ostp.gov/NSTC/html/committee/cenr.html). The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of an

PHARMACEUTICALS AND PERSONAL CARE PRODUCTS ...

EPA Pesticide Factsheets

This presentation briefly summarizes some of what is known and not known about the occurrence of drugs in the environment, the potential for chronic effects on wildlife (and some instances of acute effects), the relevance of drug residues in drinking water to consumer risk perception, and actions that can be taken to reduce environmental exposure. Efforts are underway at U.S. federal agencies such as the USGS, FDA, USDA, NOAA, NIEHS, and the CDC, as well as the EPA. This work is beginning to be coordinated under an Interagency Task Group (PiE: Pharmaceuticals in the Environment), which was chartered under a subcommittee of OSTP's (National Science and Technology Council) Committee on Environment and Natural Resources (http://www.ostp.gov/NSTC/html/committee/cenr. html). The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of an

PRESENTATION--PHARACEUTICALS AND PERSONAL ...

EPA Pesticide Factsheets

This presentation briefly summarizes some of what is known and not known about the occurrence of drugs in the environment, the potential for chronic effects on wildlife (and some instances of acute effects), the relevance of drug residues in drinking water to consumer risk perception, and actions that can be taken to reduce environmental exposure. Efforts are underway at U.S. federal agencies such as the USGS, FDA, USDA, NOAA, NIEHS, and the CDC, as well as the EPA. This work is beginning to be coordinated under an Interagency Task Group (PiE: Pharmaceuticals in the Environment), which was chartered under a subcommittee of OSTP's (National Science and Technology Council) Committee on Environment and Natural Resources (http://www.ostp.gov/NSTC/html/committee/cenr.html). The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analy

PHARMACEUTICALS IN THE ENVIRONMENT: OVERVIEW ...

EPA Pesticide Factsheets

This presentation briefly summarizes some of what is known and not known about the occurrence of drugs in the environment, the potential for chronic effects on wildlife (and some instances of acute effects), the relevance of drug residues in drinking water to consumer risk perception, and actions that can be taken to reduce environmental exposure. Efforts are underway at U.S. federal agencies such as the USGS, FDA, USDA, NOAA, NIEHS, and the CDC, as well as the EPA. This work is beginning to be coordinated under an Interagency Task Force (PiE: Pharmaceuticals in the Environment), which was chartered under a subcommittee of OSTP's (National Science and Technology Council) Committee on Environment and Natural Resources (http://www.ostp.gov/NSTC/html/committee/cenr.html). The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of ana

Enhanced oil recovery utilizing high-angle wells in the Frontier Formation, Badger Basin Field, Park County, Wyoming. Quarterly technical progress report, 1 March 1993--30 June 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fortmann, R.G.; Walker, J.P.

1993-07-10

Sierra Energy Company`s targeted goals during the third quarter of this Cooperative Agreement included the following objectives from the Statement of Work: in Phase 2A, completion of subtask 2.1.2--acquire best possible field data in the 3-D seismic program; and initiation of Subtask 2.1.3--process acquired 3-D seismic data. Technical progress is described for these tasks.

Advanced Wireless Integrated Navy Network - AWINN

DTIC Science & Technology

2005-06-30

de Sousa, GRA (5/15/05-6/30/05) George C. Hadjichristofi, GRA (4/1/05-5/14/05) Unghee Lee, GRA (33% for 4/1/05-5/14/05, 100% for 5/15/05-6/30/05...and initial implementation of test bed conversion to support Internet Protocol version 6 (IPv6). In this section, we also report on accomplishments in...below. 2.1.2 Task Activities for the Period Subtask 2. la Policy-based Quality of Service Task Obiective: The objectives of this subtask are to

Advanced thermally stable jet fuels: Technical progress report, October 1994--December 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schobert, H.H.; Eser, S.; Song, C.

There are five tasks within this project on thermally stable coal-based jet fuels. Progress on each of the tasks is described. Task 1, Investigation of the quantitative degradation chemistry of fuels, has 5 subtasks which are described: Literature review on thermal stability of jet fuels; Pyrolytic and catalytic reactions of potential endothermic fuels: cis- and trans-decalin; Use of site specific {sup 13}C-labeling to examine the thermal stressing of 1-phenylhexane: A case study for the determination of reaction kinetics in complex fuel mixtures versus model compound studies; Estimation of critical temperatures of jet fuels; and Surface effects on deposit formation inmore » a flow reactor system. Under Task 2, Investigation of incipient deposition, the subtask reported is Uncertainty analysis on growth and deposition of particles during heating of coal-derived aviation gas turbine fuels; under Task 3, Characterization of solid gums, sediments, and carbonaceous deposits, is subtask, Studies of surface chemistry of PX-21 activated carbon during thermal degradation of jet A-1 fuel and n-dodecane; under Task 4, Coal-based fuel stabilization studies, is subtask, Exploratory screening and development potential of jet fuel thermal stabilizers over 400 C; and under Task 5, Exploratory studies on the direct conversion of coal to high quality jet fuels, are 4 subtasks: Novel approaches to low-severity coal liquefaction and coal/resid co-processing using water and dispersed catalysts; Shape-selective naphthalene hydrogenation for production of thermally stable jet fuels; Design of a batch mode and a continuous mode three-phase reactor system for the liquefaction of coal and upgrading of coal liquids; and Exploratory studies on coal liquids upgrading using mesopores molecular sieve catalysts. 136 refs., 69 figs., 24 tabs.« less

Genetic Variations in SLCO Transporter Genes Contributing to Racial Disparity in Aggressiveness of Prostate Cancer

DTIC Science & Technology

2015-10-01

situ RNA hybridization staining of a TMA set and tissue sections from Roswell Park Cancer Institute (RPCI) and PCaP, respectively; 2) completion of...Facility at Roswell Park Cancer Institute (RPCI). Three Subtasks were proposed: Subtask 1 (months 1-3): Obtain approval for IRB protocol and request...Resource Network (PRN) at Roswell Park Cancer Institute (RPCI). The predominantly expressed SLCO transporters in AA or EA, and the transporters with

Unlocking Barriers to DNA Vaccine Immunogenicity: A Cross-Species Analysis of Cytosolic DNA Sensing in Skeletal Muscle Myocytes

DTIC Science & Technology

2017-10-01

CRISPR Subtask 1A: i) design and produce mammalian expression plasmids encoding the Cas9 protein and specially...duration in SOW: 2017 Q4 – 2018 Q1 Subtask 2A: i) produce mouse myocyte cell lines that have undergone gene disruption via a technique named CRISPR ii...named CRISPR ii) confirm gene disruption and GFP expression iii) select multiple individual clones characterized with quantitative gene

Early Detection of NSCLC Using Stromal Markers in Peripheral Blood

DTIC Science & Technology

2015-09-01

post- surgery patients, and COPD patients Subtask 2: Flow cytometry sorting of circulating myeloid cells. Subtask 3: RNA-Sequencing Subtask 4: RNA...recruitment including pre- and post- surgery patients, and COPD patients During this reporting period, we have recruited 23 NSCLC patients and collected

Organizational and operational models for certificate management entities as part of the connected vehicle program : revised working paper (task 2).

DOT National Transportation Integrated Search

1997-01-01

This report summarizes the efforts performed under subtasks D&E of the ATIS Communications Technology Alternatives Task for the FHWA Turner Fairbank Highway Research Center. Tasks D & E were to facilitate further examination of wireless communication...

Multiple paths in complex tasks

NASA Technical Reports Server (NTRS)

Galanter, Eugene; Wiegand, Thomas; Mark, Gloria

1987-01-01

The relationship between utility judgments of subtask paths and the utility of the task as a whole was examined. The convergent validation procedure is based on the assumption that measurements of the same quantity done with different methods should covary. The utility measures of the subtasks were obtained during the performance of an aircraft flight controller navigation task. Analyses helped decide among various models of subtask utility combination, whether the utility ratings of subtask paths predict the whole tasks utility rating, and indirectly, whether judgmental models need to include the equivalent of cognitive noise.

SOURCES & ORIGINS OF PPCPS: A COMPLEX ISSUE ...

EPA Pesticide Factsheets

There is no abstract for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. Subtask 3: T

SIMULATED HUMAN ERROR PROBABILITY AND ITS APPLICATION TO DYNAMIC HUMAN FAILURE EVENTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herberger, Sarah M.; Boring, Ronald L.

Abstract Objectives: Human reliability analysis (HRA) methods typically analyze human failure events (HFEs) at the overall task level. For dynamic HRA, it is important to model human activities at the subtask level. There exists a disconnect between dynamic subtask level and static task level that presents issues when modeling dynamic scenarios. For example, the SPAR-H method is typically used to calculate the human error probability (HEP) at the task level. As demonstrated in this paper, quantification in SPAR-H does not translate to the subtask level. Methods: Two different discrete distributions were generated for each SPAR-H Performance Shaping Factor (PSF) tomore » define the frequency of PSF levels. The first distribution was a uniform, or uninformed distribution that assumed the frequency of each PSF level was equally likely. The second non-continuous distribution took the frequency of PSF level as identified from an assessment of the HERA database. These two different approaches were created to identify the resulting distribution of the HEP. The resulting HEP that appears closer to the known distribution, a log-normal centered on 1E-3, is the more desirable. Each approach then has median, average and maximum HFE calculations applied. To calculate these three values, three events, A, B and C are generated from the PSF level frequencies comprised of subtasks. The median HFE selects the median PSF level from each PSF and calculates HEP. The average HFE takes the mean PSF level, and the maximum takes the maximum PSF level. The same data set of subtask HEPs yields starkly different HEPs when aggregated to the HFE level in SPAR-H. Results: Assuming that each PSF level in each HFE is equally likely creates an unrealistic distribution of the HEP that is centered at 1. Next the observed frequency of PSF levels was applied with the resulting HEP behaving log-normally with a majority of the values under 2.5% HEP. The median, average and maximum HFE calculations did yield different answers for the HFE. The HFE maximum grossly over estimates the HFE, while the HFE distribution occurs less than HFE median, and greater than HFE average. Conclusions: Dynamic task modeling can be perused through the framework of SPAR-H. Identification of distributions associated with each PSF needs to be defined, and may change depending upon the scenario. However it is very unlikely that each PSF level is equally likely as the resulting HEP distribution is strongly centered at 100%, which is unrealistic. Other distributions may need to be identified for PSFs, to facilitate the transition to dynamic task modeling. Additionally discrete distributions need to be exchanged for continuous so that simulations for the HFE can further advance. This paper provides a method to explore dynamic subtask to task translation and provides examples of the process using the SPAR-H method.« less

Targeting Transcription Elongation Machinery for Breast Cancer Therapy

DTIC Science & Technology

2017-04-01

activation of EMT genes in breast cancer cells. 6-30 H. Lu (Zhou) 80% Subtask 2: Determine the molecular basis underlying high sensitivity of EMT and...interaction with the molecular chaperone heat shock protein HSP90 upon the KD. Fig. 1. Knockdown (KD) of HEXIM1 in T47D cells enhances breast cancer EMT...that the observed increase in EMT in ELL2-overexpressing cells was due to the elevated P-TEFb activity. Subtask 2: Determine the molecular basis

Spinal Cord Injury-Induced Dysautonomia via Plasticity in Paravertebral Sympathetic Postganglionic

DTIC Science & Technology

2015-10-01

for future study Data analysis and publications Major Task 3: Data analysis and publications months % completion/ Completion dates Subtask 1...Data analysis 6-36 25% Subtask 2: Manuscript writing and submission 24-36 10% Milestone(s) Achieved: Dissemination of scientific results. b. What...ganglia by computational simulation and dynamic-clamp analysis . Journal of neurophysiology 92, 2659- 2671, doi:10.1152/jn.00470.2004 (2004). 14 Llewellyn

Task partitioning in a robot swarm: object retrieval as a sequence of subtasks with direct object transfer.

PubMed

Pini, Giovanni; Brutschy, Arne; Scheidler, Alexander; Dorigo, Marco; Birattari, Mauro

2014-01-01

We study task partitioning in the context of swarm robotics. Task partitioning is the decomposition of a task into subtasks that can be tackled by different workers. We focus on the case in which a task is partitioned into a sequence of subtasks that must be executed in a certain order. This implies that the subtasks must interface with each other, and that the output of a subtask is used as input for the subtask that follows. A distinction can be made between task partitioning with direct transfer and with indirect transfer. We focus our study on the first case: The output of a subtask is directly transferred from an individual working on that subtask to an individual working on the subtask that follows. As a test bed for our study, we use a swarm of robots performing foraging. The robots have to harvest objects from a source, situated in an unknown location, and transport them to a home location. When a robot finds the source, it memorizes its position and uses dead reckoning to return there. Dead reckoning is appealing in robotics, since it is a cheap localization method and it does not require any additional external infrastructure. However, dead reckoning leads to errors that grow in time if not corrected periodically. We compare a foraging strategy that does not make use of task partitioning with one that does. We show that cooperation through task partitioning can be used to limit the effect of dead reckoning errors. This results in improved capability of locating the object source and in increased performance of the swarm. We use the implemented system as a test bed to study benefits and costs of task partitioning with direct transfer. We implement the system with real robots, demonstrating the feasibility of our approach in a foraging scenario.

Air Force Research Initiation Program. 1986 Technical Report. Volume 3

DTIC Science & Technology

1988-04-01

functions quickly. b. Knowledgeable intermittent users retain the operation- al concepts. c. Error messages are rarely needed. d. Users can see...Motions," AIAA J., Vol. 23, No. 11, November 1985, pp. 1653-1659. 83-16 3.0 BEGINNING OF REGION OF FAST DYNAMIC STALL VORTEX GROWTH INITIATION OF DYNAMIC...19E6. Observations of the oil/water separator conducted during firetraining excercise March 1, 1986. Memorandum Subtask 4.31. Dynamac Corporation

Eliminating Late Recurrence to Eradicate Breast Cancer

DTIC Science & Technology

2015-09-01

induction of autophagy and antioxidant responses in Drosophila melanogaster . PLoS Genet. 9, e1003664 34 Rouschop, K.M. et al. (2010) The unfolded protein... genomic editing in human cells [8]. In contrast to RNA interference, CRISPR results in stable genetic changes in cell lines. We have generated the ...upcoming year. Since subtask 1d was delayed to pursue studies in the   Fig 2. CRISP/Cas9-Mediated Genomic Deletion of cATGs. Top: Construct

Strategic avionics technology definition studies. Subtask 3-1A: Electrical Actuation (ELA) systems

NASA Technical Reports Server (NTRS)

Lum, Ben T. F.; Pond, Charles; Dermott, William

1993-01-01

This interim report presents the preliminary results of an electrical actuation (ELA) system study (subtask TA3-1A) to support the NASA strategic avionics technology definition studies. The final report of this ELA study is scheduled for September 30, 1993. The topics are presented in viewgraph form and include the following ELA technology demonstration testing; ELA system baseline; power and energy requirements for shuttle effector systems; power efficiency and losses of ELA effector systems; and power and energy requirements for ELA power sources.

Assessing the Capabilities of Training Simulations: A Method and Simulation Networking (SIMNET) Application

DTIC Science & Technology

1990-06-01

Comments: Platoon cannot prepare for crossing the area or conduct decontamination in SIMNET. A-27 PLATOON ARTEP 17-237-10-MTP PERFORM CHEMICAL ... Chemical warfare is not represented in SIMNET. COMPANY TEAM ARTEP 71-1-MTP PERFORM LOCAL RADIOLOGICAL RECONNAISSANCE (03-2-C032) Task Rating: N Subtask... CHEMICAL ATTACK (03-2-C013) Task Ri#ting: N Subtask/Standard Ratings: +1 N aO bN 2 M aO bH 3 N aO bN Comments: Chemical warfare is not represented in the

Using a System Identification Approach to Investigate Subtask Control during Human Locomotion

PubMed Central

Logan, David; Kiemel, Tim; Jeka, John J.

2017-01-01

Here we apply a control theoretic view of movement to the behavior of human locomotion with the goal of using perturbations to learn about subtask control. Controlling one's speed and maintaining upright posture are two critical subtasks, or underlying functions, of human locomotion. How the nervous system simultaneously controls these two subtasks was investigated in this study. Continuous visual and mechanical perturbations were applied concurrently to subjects (n = 20) as probes to investigate these two subtasks during treadmill walking. Novel application of harmonic transfer function (HTF) analysis to human motor behavior was used, and these HTFs were converted to the time-domain based representation of phase-dependent impulse response functions (ϕIRFs). These ϕIRFs were used to identify the mapping from perturbation inputs to kinematic and electromyographic (EMG) outputs throughout the phases of the gait cycle. Mechanical perturbations caused an initial, passive change in trunk orientation and, at some phases of stimulus presentation, a corrective trunk EMG and orientation response. Visual perturbations elicited a trunk EMG response prior to a trunk orientation response, which was subsequently followed by an anterior-posterior displacement response. This finding supports the notion that there is a temporal hierarchy of functional subtasks during locomotion in which the control of upper-body posture precedes other subtasks. Moreover, the novel analysis we apply has the potential to probe a broad range of rhythmic behaviors to better understand their neural control. PMID:28123365

Evaluation of the Effectiveness of Training Devices: Elaboration and Application of the Predictive Model

DTIC Science & Technology

1976-07-01

consider a two-subtask case where subtask I is difficult, while subtask 2 Is easy. rurther, suppose there are two training devices designed to teach the...extra cures an which he rrMeS to rely hut whikh ire’ not ava llableF whein he Lhanqe%" frrae training to thew actual Job. Iip Ir IL.AlI -. efl ~elleont

A multistage gene normalization system integrating multiple effective methods.

PubMed

Li, Lishuang; Liu, Shanshan; Li, Lihua; Fan, Wenting; Huang, Degen; Zhou, Huiwei

2013-01-01

Gene/protein recognition and normalization is an important preliminary step for many biological text mining tasks. In this paper, we present a multistage gene normalization system which consists of four major subtasks: pre-processing, dictionary matching, ambiguity resolution and filtering. For the first subtask, we apply the gene mention tagger developed in our earlier work, which achieves an F-score of 88.42% on the BioCreative II GM testing set. In the stage of dictionary matching, the exact matching and approximate matching between gene names and the EntrezGene lexicon have been combined. For the ambiguity resolution subtask, we propose a semantic similarity disambiguation method based on Munkres' Assignment Algorithm. At the last step, a filter based on Wikipedia has been built to remove the false positives. Experimental results show that the presented system can achieve an F-score of 90.1%, outperforming most of the state-of-the-art systems.

The National Shipbuilding Research Program. Environmental Studies and Testing (Phase IV)

DTIC Science & Technology

2000-11-15

Subtask responded to the action taken by the State of Virginia to incorporate limitations of 50 parts per trillion TBT ( tributyltin ) in shipyard...Funds actually expended totaled $6,750. Subtask #22 - Document Technologies Available to Clean Brackish Waters to 50 parts per trillion TBT Levels. This...Subtask concluded that there were NO technologies extant to achieve a reduction in shipyard effluent TBT to below 50 ppt. This has become an

Small Engine Technology (SET) - Task 13 ANOPP Noise Prediction for Small Engines: Jet Noise Prediction Module, Wing Shielding Module, and System Studies Results

NASA Technical Reports Server (NTRS)

Lieber, Lysbeth; Golub, Robert (Technical Monitor)

2000-01-01

This Final Report has been prepared by AlliedSignal Engines and Systems, Phoenix, Arizona, documenting work performed during the period May 1997 through June 1999, under the Small Engines Technology Program, Contract No. NAS3-27483, Task Order 13, ANOPP Noise Prediction for Small Engines. The report specifically covers the work performed under Subtasks 4, 5 and 6. Subtask 4 describes the application of a semi-empirical procedure for jet noise prediction, subtask 5 describes the development of a procedure to predict the effects of wing shielding, and subtask 6 describes the results of system studies of the benefits of the new noise technology on business and regional aircraft.

ABSTRACT PRESENTATION--PHARMACEUTICALS AS ...

EPA Pesticide Factsheets

Pharmaceuticals comprise a large and diverse array of contaminants that can occur in the environmentfrom the combined activities and actions of multitudes of individuals as well as from veterinary andagricultural use. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for med

ION COMPOSITION ELUCIDATION (ICE) FOR ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PHARMACEUTICALS AND PERSONAL CARE PRODUCTS ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PHARMACEUTICAL AND PERSONAL CARE PRODUCTS IN ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

OVERVIEW OF PHARMACEUTICALS AND PERSONAL ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

ORIGINS AND RAMIFICATIONS OF PHARMACEUTICALS & ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PHARMACEUTICAL AND PERSONAL CARE PRODUCTS ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

ORIGINS AND RAMIFICATIONS OF PHARMACEUTICALS ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PHARMACEUTICALS AS ENVIRONMENTAL ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

MERCURY MEASUREMENTS USING DIRECT-ANALYZER ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact Field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

SLIDE PRESENTATION--PHARMACEUTICALS AS ...

EPA Pesticide Factsheets

While pharmaceuticals are ubiquitous trace contaminants in the environment, thetypes, concentrations, and relative abundances of individual residues will vary depending on thegeographic locale and time of year, primarily a reflection of differing and varying prescribing andconsumption practices. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical

SYNTHETIC FRAGRANCES IN THE ENVIRONMENT ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

ENVIRONMENTAL STEWARDSHIP OF PHARMACEUTICALS ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

INVESTIGATING ENVIRONMENTAL SINKS OF MACROLIDE ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under the Contact Field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquirie

LEVELS OF SYNTHETIC MUSKS COMPOUNDS IN ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

ADVANCED TOOLS FOR ASSESSING SELECTED ...

EPA Pesticide Factsheets

The purpose of this poster is to present the application and assessment of advanced technologies in a real-world environment - wastewater effluent and source waters - for detecting six drugs (azithromycin, fluoxetine, omeprazole, levothyroxine, methamphetamine, and methylenedioxymethamphetamine). The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technica

POTENTIAL CONCERNS/EFFECTS ON HUMAN AND ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

MEETING TODAY'S EMERGING CONTAMINANTS WITH ...

EPA Pesticide Factsheets

This presentation will explore the many facets of research and development for emerging contaminants within the USEPA's National Exposure Research Laboratories (Athens, Cincinnati, Las Vegas, and Research Triangle Park). The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for

NON-REGULATED CONTAMINANTS: EMERGING ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

DETECTION OF ILLCIT DRUGS IN MUNICIPAL ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

ADVANCED TOOLS FOR ASSESSING SELECTED ...

EPA Pesticide Factsheets

The purpose of this poster is to present the application and assessment of advanced state-of-the-art technologies in a real-world environment - wastewater effluent and source waters - for detecting six drugs [azithromycin, fluoxetine, omeprazole, levothyroxine, methamphetamine, methylenedioxymethamphetamine (MDMA)]. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansi

PRESCRIBING FOR THE ENVIRONMENT | Science Inventory ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact Field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

A NEW HIGH RESOLUTION MASS SPECTROMEY ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PHARMACEUTICALS IN SOURCE WATER - OVERVIEW ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

SPECIATION AND DETECTION OF ORGANOTINS FROM ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

NEW APPROACHES FOR TRACE ANALYSIS OF ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

ANTIBIOTICS IN THE ENVIRONMENTS; LESS RECOGNIZED ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

Associations between Quantitative Mobility Measures Derived from Components of Conventional Mobility Testing and Parkinsonian Gait in Older Adults

PubMed Central

Buchman, Aron S.; Leurgans, Sue E.; Weiss, Aner; VanderHorst, Veronique; Mirelman, Anat; Dawe, Robert; Barnes, Lisa L.; Wilson, Robert S.; Hausdorff, Jeffrey M.; Bennett, David A.

2014-01-01

Objective To provide objective measures which characterize mobility in older adults assessed in the community setting and to examine the extent to which these measures are associated with parkinsonian gait. Methods During conventional mobility testing in the community-setting, 351 ambulatory non-demented Memory and Aging Project participants wore a belt with a whole body sensor that recorded both acceleration and angular velocity in 3 directions. We used measures derived from these recordings to quantify 5 subtasks including a) walking, b) transition from sit to stand, c) transition from stand to sit, d) turning and e) standing posture. Parkinsonian gait and other mild parkinsonian signs were assessed with a modified version of the original Unified Parkinson’s Disease Rating Scale (mUPDRS). Results In a series of separate regression models which adjusted for age and sex, all 5 mobility subtask measures were associated with parkinsonian gait and accounted for 2% to 32% of its variance. When all 5 subtask measures were considered in a single model, backward elimination showed that measures of walking sit to stand and turning showed independent associations with parkinsonian gait and together accounted for more than 35% of its variance. Cross-validation using data from a 2nd group of 258 older adults showed similar results. In similar analyses, only walking was associated with bradykinesia and sway with tremor. Interpretation Quantitative mobility subtask measures vary in their associations with parkinsonian gait scores and other parkinsonian signs in older adults. Quantifying the different facets of mobility has the potential to facilitate the clinical characterization and understanding the biologic basis for impaired mobility in older adults. PMID:24465997

C-Band Airport Surface Communications System Standards Development. Phase II Final Report. Volume 1: Concepts of Use, Initial System Requirements, Architecture, and AeroMACS Design Considerations

NASA Technical Reports Server (NTRS)

Hall, Edward; Isaacs, James; Henriksen, Steve; Zelkin, Natalie

2011-01-01

This report is provided as part of ITT s NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract NNC05CA85C, Task 7: New ATM Requirements-Future Communications, C-Band and L-Band Communications Standard Development and was based on direction provided by FAA project-level agreements for New ATM Requirements-Future Communications. Task 7 included two subtasks. Subtask 7-1 addressed C-band (5091- to 5150-MHz) airport surface data communications standards development, systems engineering, test bed and prototype development, and tests and demonstrations to establish operational capability for the Aeronautical Mobile Airport Communications System (AeroMACS). Subtask 7-2 focused on systems engineering and development support of the L-band digital aeronautical communications system (L-DACS). Subtask 7-1 consisted of two phases. Phase I included development of AeroMACS concepts of use, requirements, architecture, and initial high-level safety risk assessment. Phase II builds on Phase I results and is presented in two volumes. Volume I (this document) is devoted to concepts of use, system requirements, and architecture, including AeroMACS design considerations. Volume II describes an AeroMACS prototype evaluation and presents final AeroMACS recommendations. This report also describes airport categorization and channelization methodologies. The purposes of the airport categorization task were (1) to facilitate initial AeroMACS architecture designs and enable budgetary projections by creating a set of airport categories based on common airport characteristics and design objectives, and (2) to offer high-level guidance to potential AeroMACS technology and policy development sponsors and service providers. A channelization plan methodology was developed because a common global methodology is needed to assure seamless interoperability among diverse AeroMACS services potentially supplied by multiple service providers.

Detection and categorization of bacteria habitats using shallow linguistic analysis

PubMed Central

2015-01-01

Background Information regarding bacteria biotopes is important for several research areas including health sciences, microbiology, and food processing and preservation. One of the challenges for scientists in these domains is the huge amount of information buried in the text of electronic resources. Developing methods to automatically extract bacteria habitat relations from the text of these electronic resources is crucial for facilitating research in these areas. Methods We introduce a linguistically motivated rule-based approach for recognizing and normalizing names of bacteria habitats in biomedical text by using an ontology. Our approach is based on the shallow syntactic analysis of the text that include sentence segmentation, part-of-speech (POS) tagging, partial parsing, and lemmatization. In addition, we propose two methods for identifying bacteria habitat localization relations. The underlying assumption for the first method is that discourse changes with a new paragraph. Therefore, it operates on a paragraph-basis. The second method performs a more fine-grained analysis of the text and operates on a sentence-basis. We also develop a novel anaphora resolution method for bacteria coreferences and incorporate it with the sentence-based relation extraction approach. Results We participated in the Bacteria Biotope (BB) Task of the BioNLP Shared Task 2013. Our system (Boun) achieved the second best performance with 68% Slot Error Rate (SER) in Sub-task 1 (Entity Detection and Categorization), and ranked third with an F-score of 27% in Sub-task 2 (Localization Event Extraction). This paper reports the system that is implemented for the shared task, including the novel methods developed and the improvements obtained after the official evaluation. The extensions include the expansion of the OntoBiotope ontology using the training set for Sub-task 1, and the novel sentence-based relation extraction method incorporated with anaphora resolution for Sub-task 2. These extensions resulted in promising results for Sub-task 1 with a SER of 68%, and state-of-the-art performance for Sub-task 2 with an F-score of 53%. Conclusions Our results show that a linguistically-oriented approach based on the shallow syntactic analysis of the text is as effective as machine learning approaches for the detection and ontology-based normalization of habitat entities. Furthermore, the newly developed sentence-based relation extraction system with the anaphora resolution module significantly outperforms the paragraph-based one, as well as the other systems that participated in the BB Shared Task 2013. PMID:26201262

Carbohydrate crops as a renewable resource for fuels production. Volume III. Juice preservation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fink, D.J.; Allen, B.R.; Litchfield, J.H.

1980-01-29

The objective of this study was to evaluate a process to preserve sugar crop juices. The process is energy conserving in that concentrated sugar solutions are produced with little evaporation of water. A preliminary investigation was conducted of polysaccharide hydrolysis as a means for preserving mixed sugar solutions obtained from crops such as sweet sorghum. Four subtasks have been addressed during this report period: I. Concentration of Pure Sugar Solutions by Hydrolysis of Purified Starch; II. Concentration of Genuine Sugar Crop Juice by Hydrolysis of Purified Starch; III. Concentration of Pure Sugar Solutions by Hydrolysis of Genuine Biomass Starch; andmore » IV. Concentration of Pure Sugar Solutions by Hydrolysis of Cellulosic Materials. The results obtained from the experiments conducted in Subtasks I and II included the following: (1) Concentrated sucrose-glucose-fructose solutions (greater than 50 percent) can be prepared from simulated or actual sweet sorghum juice using enzymatic thinning and saccharification of pure starch-sugar solution mixtures. (2) Enzymatic saccharification of corn meal and cracked wheat in simulated sorghum juice was also demonstrated. (3) Concentration of sugar solutions also can be accomplished by saccharification of cellulosic materials. In our experiments, inhibition of the cellobiase component of the cellulase preparation was observed. The hydrolysis studies were directed to the demonstration of the feasibility of one approach to the preparation of concentrated, microbiologically stable sugar syrups starting with sweet sorghum juice. Future work on Subtask V of this program will continue the investigations already underway and will consider other approaches to the stabilization of juices. Subtask VI of this program will consider the process economics of the Subtask I to IV approaches, or combinations of two or more methods, that are considered to be most feasible for juice preservation.« less

An assessment of commercial motor vehicle driver distraction using naturalistic driving data.

PubMed

Hickman, Jeffrey S; Hanowski, Richard J

2012-01-01

This study analyzed naturalistic driving data from commercial trucks (3-axle and tractor-trailer/tanker) and buses (transit and motorcoach) during a 3-month period. The data set contained 183 commercial truck and bus fleets comprising 13,306 vehicles and included 1085 crashes, 8375 near crashes, 30,661 crash-relevant conflicts, and 211,171 baseline events. Study results documented the prevalence of tertiary tasks and the risks associated with performing these tasks while driving. Results indicated the odds of involvement in a safety-critical event differed as a function of performing different cell phone-related subtasks while driving. Although the odds ratio for talking/listening on a cell phone while driving was found to not significantly increase the likelihood of involvement in a safety-critical event, other cell phone subtasks (e.g., texting, dialing, reaching) were found to significantly increase the odds of involvement in a safety-critical event. The results suggest that cell phone use while driving should not be considered a simple dichotomous task (yes/no). Consideration should instead be made for a set of discrete cell phone subtasks that are each associated with varying levels of risk. Several hypotheses are presented to explain why cell phone use while driving was found to not increase the likelihood of involvement in a safety-critical event.

Northwest National Marine Renewable Energy Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batten, Belinda; Polagye, Brian

In 2008, the US Department of Energy’s (DOE) Wind and Water Power Program issued a funding opportunity announcement to establish university-led National Marine Renewable Energy Centers. Oregon State University and the University of Washington combined their capabilities in wave and tidal energy to establish the Northwest National Marine Renewable Energy Center, or NNMREC. NNMREC’s scope included research and testing in the following topic areas: • Advanced Wave Forecasting Technologies; • Device and Array Optimization; • Integrated and Standardized Test Facility Development; • Investigate the Compatibility of Marine Energy Technologies with Environment, Fisheries and other Marine Resources; • Increased Reliability andmore » Survivability of Marine Energy Systems; • Collaboration/Optimization with Marine Renewable and Other Renewable Energy Resources. To support the last topic, the National Renewable Energy Laboratory (NREL) was brought onto the team, particularly to assist with testing protocols, grid integration, and testing instrumentation. NNMREC’s mission is to facilitate the development of marine energy technology, to inform regulatory and policy decisions, and to close key gaps in scientific understanding with a focus on workforce development. In this, NNMREC achieves DOE’s goals and objectives and remains aligned with the research and educational mission of universities. In 2012, DOE provided NNMREC an opportunity to propose an additional effort to begin work on a utility scale, grid connected wave energy test facility. That project, initially referred to as the Pacific Marine Energy Center, is now referred to as the Pacific Marine Energy Center South Energy Test Site (PMEC-SETS) and involves work directly toward establishing the facility, which will be in Newport Oregon, as well as supporting instrumentation for wave energy converter testing. This report contains a breakdown per subtask of the funded project. Under each subtask, the following are presented and discussed where appropriate: the initial objective or hypothesis; an overview of accomplishments and approaches used; any problems encountered or departures from planned methodology over the life of the project; impacts of the problems or rescoping of the project; how accomplishments compared with original project goals; and deliverables under the subtasks. Products and models developed under the award are also included.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batten, Belinda; Polagye, Brian; LiVecchi, Al

In 2008, the US Department of Energy’s (DOE) Wind and Water Power Program issued a funding opportunity announcement to establish university-led National Marine Renewable Energy Centers. Oregon State University and the University of Washington combined their capabilities in wave and tidal energy to establish the Northwest National Marine Renewable Energy Center, or NNMREC. NNMREC’s scope included research and testing in the following topic areas: • Advanced Wave Forecasting Technologies; • Device and Array Optimization; • Integrated and Standardized Test Facility Development; • Investigate the Compatibility of Marine Energy Technologies with Environment, Fisheries and other Marine Resources; • Increased Reliability andmore » Survivability of Marine Energy Systems; • Collaboration/Optimization with Marine Renewable and Other Renewable Energy Resources. To support the last topic, the National Renewable Energy Laboratory (NREL) was brought onto the team, particularly to assist with testing protocols, grid integration, and testing instrumentation. NNMREC’s mission is to facilitate the development of marine energy technology, to inform regulatory and policy decisions, and to close key gaps in scientific understanding with a focus on workforce development. In this, NNMREC achieves DOE’s goals and objectives and remains aligned with the research and educational mission of universities. In 2012, DOE provided NNMREC an opportunity to propose an additional effort to begin work on a utility scale, grid connected wave energy test facility. That project, initially referred to as the Pacific Marine Energy Center, is now referred to as the Pacific Marine Energy Center South Energy Test Site (PMEC-SETS) and involves work directly toward establishing the facility, which will be in Newport Oregon, as well as supporting instrumentation for wave energy converter testing. This report contains a breakdown per subtask of the funded project. Under each subtask, the following are presented and discussed where appropriate: the initial objective or hypothesis; an overview of accomplishments and approaches used; any problems encountered or departures from planned methodology over the life of the project; impacts of the problems or rescoping of the project; how accomplishments compared with original project goals; and deliverables under the subtasks. Products and models developed under the award are also included.« less

Enhanced oil recovery utilizing high-angle wells in the Frontier Formation, Badger Basin Field, Park County, Wyoming. Quarterly technical progress report, 1 January 1994--31 March 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fortmann, R.G.

1994-04-22

Sierra Energy Company, in consultation with Rim Companies, concluded that additional work was required for Subtask 2.1.4 -- Interpret data, of Task 2.1 - Acquire 3-D seismic data. The goal of this subtask was to interpret the 3-D seismic data, using a workstation, in order to locate the surface and subsurface positions for the slant and horizontal wellbores. Although this goal had been reached, more work was needed for plotting maps and seismic sections. Furthermore, it was determined that an additional look at the amplitude distribution in the Frontier sands would greatly benefit the interpretation.

Development of Game-Like Simulations for Procedural Knowledge in Healthcare Education

ERIC Educational Resources Information Center

Torrente, Javier; Borro-Escribano, Blanca; Freire, Manuel; del Blanco, Ángel; Marchiori, Eugenio J.; Martinez-Ortiz, Iván; Moreno-Ger, Pablo; Fernández-Manjón, Baltasar

2014-01-01

We present EGDA, an educational game development approach focused on the teaching of procedural knowledge using a cost-effective approach. EGDA proposes four tasks: analysis, design, implementation, and quality assurance that are subdivided in a total of 12 subtasks. One of the benefits of EGDA is that anyone can apply it to develop a game since…

The CSM testbed matrix processors internal logic and dataflow descriptions

NASA Technical Reports Server (NTRS)

Regelbrugge, Marc E.; Wright, Mary A.

1988-01-01

This report constitutes the final report for subtask 1 of Task 5 of NASA Contract NAS1-18444, Computational Structural Mechanics (CSM) Research. This report contains a detailed description of the coded workings of selected CSM Testbed matrix processors (i.e., TOPO, K, INV, SSOL) and of the arithmetic utility processor AUS. These processors and the current sparse matrix data structures are studied and documented. Items examined include: details of the data structures, interdependence of data structures, data-blocking logic in the data structures, processor data flow and architecture, and processor algorithmic logic flow.

Concurrent Path Planning with One or More Humanoid Robots

NASA Technical Reports Server (NTRS)

Reiland, Matthew J. (Inventor); Sanders, Adam M. (Inventor)

2014-01-01

A robotic system includes a controller and one or more robots each having a plurality of robotic joints. Each of the robotic joints is independently controllable to thereby execute a cooperative work task having at least one task execution fork, leading to multiple independent subtasks. The controller coordinates motion of the robot(s) during execution of the cooperative work task. The controller groups the robotic joints into task-specific robotic subsystems, and synchronizes motion of different subsystems during execution of the various subtasks of the cooperative work task. A method for executing the cooperative work task using the robotic system includes automatically grouping the robotic joints into task-specific subsystems, and assigning subtasks of the cooperative work task to the subsystems upon reaching a task execution fork. The method further includes coordinating execution of the subtasks after reaching the task execution fork.

C-Band Airport Surface Communications System Standards Development. Phase II Final Report. Volume 2: Test Bed Performance Evaluation and Final AeroMACS Recommendations

NASA Technical Reports Server (NTRS)

Hall, Edward; Magner, James

2011-01-01

This report is provided as part of ITT s NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract NNC05CA85C, Task 7: New ATM Requirements-Future Communications, C-Band and L-Band Communications Standard Development and was based on direction provided by FAA project-level agreements for New ATM Requirements-Future Communications. Task 7 included two subtasks. Subtask 7-1 addressed C-band (5091- to 5150-MHz) airport surface data communications standards development, systems engineering, test bed and prototype development, and tests and demonstrations to establish operational capability for the Aeronautical Mobile Airport Communications System (AeroMACS). Subtask 7-2 focused on systems engineering and development support of the L-band digital aeronautical communications system (L-DACS). Subtask 7-1 consisted of two phases. Phase I included development of AeroMACS concepts of use, requirements, architecture, and initial high-level safety risk assessment. Phase II builds on Phase I results and is presented in two volumes. Volume I is devoted to concepts of use, system requirements, and architecture, including AeroMACS design considerations. Volume II (this document) describes an AeroMACS prototype evaluation and presents final AeroMACS recommendations. This report also describes airport categorization and channelization methodologies. The purposes of the airport categorization task were (1) to facilitate initial AeroMACS architecture designs and enable budgetary projections by creating a set of airport categories based on common airport characteristics and design objectives, and (2) to offer high-level guidance to potential AeroMACS technology and policy development sponsors and service providers. A channelization plan methodology was developed because a common global methodology is needed to assure seamless interoperability among diverse AeroMACS services potentially supplied by multiple service providers.

PHARMACEUTICALS IN THE ENVIRONMENT: SOURCES ...

EPA Pesticide Factsheets

An issue that began to receive more attention by environmental scientists in the late 1990s was the conveyancy of pharmaceuticals in the environment by way of their use in human and veterinary medical practices and personal care The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, intervi

ION COMPOSITION ELUCIDATION (ICE) OF IONS FROM ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PHARMACEUTICALS AND PERSONAL CARE PRODUCTS ...

EPA Pesticide Factsheets

This presentation briefly summarizes some of what is known and not known about the occurrence of drugs in the environment, the potential for chronic effects on wildlife (and some instances of acute effects), the relevance of drug residues in drinking water to consumer risk perception, and actions that can be taken to reduce environmental exposure. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs.

PHARMACEUTICALS & PERSONAL CARE PRODUCTS AS ...

EPA Pesticide Factsheets

Those chemical pollutants that are regulated under various international, federal, and state programs represent but a small fraction of the universe of chemicals that occur in the environment as a result of both natural processes and human influence. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-revi

US EPA, NERL-LAS VEGAS ACTIVITIES AND RESEARCH ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

Introduction to Pharmaceuticals and Personal Care Products ...

EPA Pesticide Factsheets

Those chemical pollutants that are regulated under various international, federal, and state programs represent but a small fraction of the universe of chemicals that occur in the environment as a result of both natural processes and human influence. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-revi

CHEMICAL MARKERS OF HUMAN WASTE ...

EPA Pesticide Factsheets

Giving public water authorities a tool to monitor and measure levels of human waste contamination of waters simply and rapidly would enhance public protection. This methodology, using both urobilin and azithromycin (or any other human-use pharmaceutical) could be used to give public water authorities a rapid (24- hrs) and definitive method for measuring human waste contamination The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subco

PRESENTATION ON PPCPS IN THE ENVIRONMENT: AN ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact Field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PPCPS IN THE ENVIRONMENT: AN OVERVIEW OF THE ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact Field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PHARMACEUTICALS IN THE ENVIRONMENT: A ...

EPA Pesticide Factsheets

This presentation briefly summarizes some of what is known, and not known about the occurrence of drugs in the environment, the potential for effects on wildlife, the relevance of drug residues in drinking water to consumer risk perception, and actions that can be taken to reduce environmental exposure. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited t

PRESENTED 04/05/2006: MERCURY MEASUREMENTS ...

EPA Pesticide Factsheets

While traditional methods for determining mercury in solid samples involve the use of aggressive chemicals to dissolve the matrix and the use of other chemicals to properly reduce the mercury to the volatile elemental form, pyrolysis-based analyzers can be used by directly weighing the solid in a sampling boat and initiating the instrumental analysis for total mercury. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee wo

TELEPHONIC PRESENTATION: MERCURY ...

EPA Pesticide Factsheets

While traditional methods for determining mercury in solid samples involve the use of aggressive chemicals to dissolve the matrix and the use of other chemicals to properly reduce the mercury to the volatile elemental form, pyrolysis-based analyzers can be used by directly weighing the solid in a sampling boat and initiating the instrumental analysis for total mercury. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee wo

PCCPS IN THE ENVIRONMENT: AN OVERVIEW OF THE ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact Field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PPCPS AS UBIQUITOUS POLLUTANTS FROM HEALTH AND ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

MEDICATION DISPOSAL AS A SOURCE FOR DRUGS AS ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact Field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

PRESENTATION FOR THE PPCPS IN THE ENVIRONMENT ...

EPA Pesticide Factsheets

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact Field. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subcommittee working group on PPCPs. Web site maintenance and expansion, invited technical presentations, invited articles for peer-reviewed journals, interviews for media, responding to public inquiries. S

CHEMICAL MARKERS OF HUMAN WASTE ...

EPA Pesticide Factsheets

Giving public water authorities a tool to monitor and measure levels of human waste contamination of waters simply and rapidly would enhance public protection. This methodology, using both urobilin and azithromycin (or any other human-use pharmaceutical) could be used to give public water authorities a rapid (24- hrs) and definitive method for measuring human waste contamination. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG with USGS ends in FY05. APM 20 due in FY05.Subtask 2: Coordination of interagency research and public outreach activities for PPCPs. Participate on NSTC Health and Environment subc

Design issues for grid-connected photovoltaic systems

NASA Astrophysics Data System (ADS)

Ropp, Michael Eugene

1998-08-01

Photovoltaics (PV) is the direct conversion of sunlight to electrical energy. In areas without centralized utility grids, the benefits of PV easily overshadow the present shortcomings of the technology. However, in locations with centralized utility systems, significant technical challenges remain before utility-interactive PV (UIPV) systems can be integrated into the mix of electricity sources. One challenge is that the needed computer design tools for optimal design of PV systems with curved PV arrays are not available, and even those that are available do not facilitate monitoring of the system once it is built. Another arises from the issue of islanding. Islanding occurs when a UIPV system continues to energize a section of a utility system after that section has been isolated from the utility voltage source. Islanding, which is potentially dangerous to both personnel and equipment, is difficult to prevent completely. The work contained within this thesis targets both of these technical challenges. In Task 1, a method for modeling a PV system with a curved PV array using only existing computer software is developed. This methodology also facilitates comparison of measured and modeled data for use in system monitoring. The procedure is applied to the Georgia Tech Aquatic Center (GTAC) FV system. In the work contained under Task 2, islanding prevention is considered. The existing state-of-the- art is thoroughly reviewed. In Subtask 2.1, an analysis is performed which suggests that standard protective relays are in fact insufficient to guarantee protection against islanding. In Subtask 2.2. several existing islanding prevention methods are compared in a novel way. The superiority of this new comparison over those used previously is demonstrated. A new islanding prevention method is the subject under Subtask 2.3. It is shown that it does not compare favorably with other existing techniques. However, in Subtask 2.4, a novel method for dramatically improving this new islanding prevention method is described. It is shown, both by computer modeling and experiment, that this new method is one of the most effective available today. Finally, under Subtask 2.5, the effects of certain types of loads; on the effectiveness of islanding prevention methods are discussed.

[Features of dual--postural and calculation--task performance in patients with consequences of traumatic brain injury].

PubMed

Zharikova, A V; Zhavoronkova, L A; Maksakova, O A; Kuptsova, S V

2012-01-01

Dual tasks with voluntary postural control and calculation have been done by 14 patients (25.7 +/- 4.7 yo.) after traumatic brain injury and 40 healthy volunteers (29.8 +/- 2.5 y.o.). Complex clinical (MMSE, FIM, MPAI-3 and Berg scales) and stabilographic evaluation has been performed. According to clinical evaluation 8 patients were included into group 1 with less severe functional deficit and 6 patients formed group 2 with more severe deficit. Parameters of motor and especially cognitive sub-tasks in patients were lower than in healthy subjects in both separate and dual tasks. In group 2 these parameters were lower than in group 1. Certain types of dual task where the quality of sub-tasks, especially of the motor-one increased in healthy subjects and patients of the first group were revealed. The complex of stabilographic parameters which could be used for estimation of quality of sub-tasks performance has been revealed. Dual tasks could be an additional method of evaluation of patients' adaptive possibilities and certain type of dual task could become a promising approach to recovery at late period of rehabilitation.

Monovision techniques for telerobots

NASA Technical Reports Server (NTRS)

Goode, P. W.; Carnils, K.

1987-01-01

The primary task of the vision sensor in a telerobotic system is to provide information about the position of the system's effector relative to objects of interest in its environment. The subtasks required to perform the primary task include image segmentation, object recognition, and object location and orientation in some coordinate system. The accomplishment of the vision task requires the appropriate processing tools and the system methodology to effectively apply the tools to the subtasks. The functional structure of the telerobotic vision system used in the Langley Research Center's Intelligent Systems Research Laboratory is discussed as well as two monovision techniques for accomplishing the vision subtasks.

Crack stability in a representative piping system under combined inertial and seismic/dynamic displacement-controlled stresses. Subtask 1.3 final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scott, P.; Olson, R.; Wilkowski, O.G.

1997-06-01

This report presents the results from Subtask 1.3 of the International Piping Integrity Research Group (IPIRG) program. The objective of Subtask 1.3 is to develop data to assess analysis methodologies for characterizing the fracture behavior of circumferentially cracked pipe in a representative piping system under combined inertial and displacement-controlled stresses. A unique experimental facility was designed and constructed. The piping system evaluated is an expansion loop with over 30 meters of 16-inch diameter Schedule 100 pipe. The experimental facility is equipped with special hardware to ensure system boundary conditions could be appropriately modeled. The test matrix involved one uncracked andmore » five cracked dynamic pipe-system experiments. The uncracked experiment was conducted to evaluate piping system damping and natural frequency characteristics. The cracked-pipe experiments evaluated the fracture behavior, pipe system response, and stability characteristics of five different materials. All cracked-pipe experiments were conducted at PWR conditions. Material characterization efforts provided tensile and fracture toughness properties of the different pipe materials at various strain rates and temperatures. Results from all pipe-system experiments and material characterization efforts are presented. Results of fracture mechanics analyses, dynamic finite element stress analyses, and stability analyses are presented and compared with experimental results.« less

The risk of a safety-critical event associated with mobile device use in specific driving contexts.

PubMed

Fitch, Gregory M; Hanowski, Richard J; Guo, Feng

2015-01-01

We explored drivers' mobile device use and its associated risk of a safety-critical event (SCE) in specific driving contexts. Our premise was that the SCE risk associated with mobile device use increases when the driving task becomes demanding. Data from naturalistic driving studies involving commercial motor vehicle drivers and light vehicle drivers were partitioned into subsets representative of specific driving contexts. The subsets were generated using data set attributes that included level of service and relation to junction. These attributes were selected based on exogenous factors known to alter driving task demands. The subsets were analyzed using a case-cohort approach, which was selected to complement previous investigations of mobile device SCE risk using naturalistic driving data. Both commercial motor vehicle and light vehicle drivers varied as to how much they conversed on a mobile device but did not vary their engagement in visual-manual subtasks. Furthermore, commercial motor vehicle drivers conversed less frequently as the driving task demands increased, whereas light vehicle drivers did not. The risk of an SCE associated with mobile device use was dependent on the subtask performed and the driving context. Only visual-manual subtasks were associated with an increased SCE risk, whereas conversing was associated with a decreased risk in some driving contexts. Drivers' engagement in mobile device subtasks varies by driving context. The SCE risk associated with mobile device use is dependent on the types of subtasks performed and the driving context. The findings of this exploratory study can be applied to the design of driver-vehicle interfaces that mitigate distraction by preventing visual-manual subtasks while driving.

Selective control of gait subtasks in robotic gait training: foot clearance support in stroke survivors with a powered exoskeleton

PubMed Central

2013-01-01

Background Robot-aided gait training is an emerging clinical tool for gait rehabilitation of neurological patients. This paper deals with a novel method of offering gait assistance, using an impedance controlled exoskeleton (LOPES). The provided assistance is based on a recent finding that, in the control of walking, different modules can be discerned that are associated with different subtasks. In this study, a Virtual Model Controller (VMC) for supporting one of these subtasks, namely the foot clearance, is presented and evaluated. Methods The developed VMC provides virtual support at the ankle, to increase foot clearance. Therefore, we first developed a new method to derive reference trajectories of the ankle position. These trajectories consist of splines between key events, which are dependent on walking speed and body height. Subsequently, the VMC was evaluated in twelve healthy subjects and six chronic stroke survivors. The impedance levels, of the support, were altered between trials to investigate whether the controller allowed gradual and selective support. Additionally, an adaptive algorithm was tested, that automatically shaped the amount of support to the subjects’ needs. Catch trials were introduced to determine whether the subjects tended to rely on the support. We also assessed the additional value of providing visual feedback. Results With the VMC, the step height could be selectively and gradually influenced. The adaptive algorithm clearly shaped the support level to the specific needs of every stroke survivor. The provided support did not result in reliance on the support for both groups. All healthy subjects and most patients were able to utilize the visual feedback to increase their active participation. Conclusion The presented approach can provide selective control on one of the essential subtasks of walking. This module is the first in a set of modules to control all subtasks. This enables the therapist to focus the support on the subtasks that are impaired, and leave the other subtasks up to the patient, encouraging him to participate more actively in the training. Additionally, the speed-dependent reference patterns provide the therapist with the tools to easily adapt the treadmill speed to the capabilities and progress of the patient. PMID:23336754

Echinostoma revolutum: freshwater snails as the second intermediate hosts in Chiang Mai, Thailand.

PubMed

Chantima, Kittichai; Chai, Jong-Yil; Wongsawad, Chalobol

2013-04-01

The occurrence of 37-collar spined echinostome metacercariae in freshwater snails was investigated in 6 districts of Chiang Mai Province, Thailand, from October 2011 to April 2012. A total of 2,914 snails that belong to 12 species were examined, and 7 snail species (Clea helena, Eyriesia eyriesi, Bithynia funiculata, Bithynia siamensis siamensis, Filopaludina doliaris, Filopaludina sumatrensis polygramma, and Filopaludina martensi martensi) were found infected with echinostome metacercariae. The prevalence of metacercariae was the highest in Filopaludina spp. (38.5-58.7%) followed by B. funiculata (44.0%), E. eyriesi (12.5%), B. siamensis siamensis (8.2%), and C. helena (5.1%). Metacercariae were experimentally fed to hamsters and domestic chicks, and adult flukes were recovered from both hosts at days 15 and 20 post-infection. The adult flukes were identified based on morphological features, morphometrics, host-parasite relationships, and geographical distribution. They were compatible to Echinostoma revolutum or Echinostoma jurini, with only minor differences. As the adults were recovered from both hamsters and chicks, our specimens were more compatible to E. revolutum rather than E. jurini (reported only from mammals). This is the first report for metacercariae of E. revolutum in the snail host, C. helena, and also confirmed that Filopaludina spp., E. eryresi, and Bithynia spp. act as the second intermediate hosts of E. revolutum under natural conditions, which are indigenously distributed in Chiang Mai province.

Echinostoma revolutum: Freshwater Snails as the Second Intermediate Hosts in Chiang Mai, Thailand

PubMed Central

Chantima, Kittichai; Chai, Jong-Yil

2013-01-01

The occurrence of 37-collar spined echinostome metacercariae in freshwater snails was investigated in 6 districts of Chiang Mai Province, Thailand, from October 2011 to April 2012. A total of 2,914 snails that belong to 12 species were examined, and 7 snail species (Clea helena, Eyriesia eyriesi, Bithynia funiculata, Bithynia siamensis siamensis, Filopaludina doliaris, Filopaludina sumatrensis polygramma, and Filopaludina martensi martensi) were found infected with echinostome metacercariae. The prevalence of metacercariae was the highest in Filopaludina spp. (38.5-58.7%) followed by B. funiculata (44.0%), E. eyriesi (12.5%), B. siamensis siamensis (8.2%), and C. helena (5.1%). Metacercariae were experimentally fed to hamsters and domestic chicks, and adult flukes were recovered from both hosts at days 15 and 20 post-infection. The adult flukes were identified based on morphological features, morphometrics, host-parasite relationships, and geographical distribution. They were compatible to Echinostoma revolutum or Echinostoma jurini, with only minor differences. As the adults were recovered from both hamsters and chicks, our specimens were more compatible to E. revolutum rather than E. jurini (reported only from mammals). This is the first report for metacercariae of E. revolutum in the snail host, C. helena, and also confirmed that Filopaludina spp., E. eryresi, and Bithynia spp. act as the second intermediate hosts of E. revolutum under natural conditions, which are indigenously distributed in Chiang Mai province. PMID:23710085

L-Band System Engineering - Concepts of Use, Systems Performance Requirements, and Architecture

NASA Technical Reports Server (NTRS)

Henriksen, Stephen; Zelkin, Natalie

2011-01-01

This document is being provided as part of ITT s NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract NNC05CA85C, Task 7: New ATM Requirements-Future Communications, C-band and L-band Communications Standard Development. Task 7 was motivated by the five year technology assessment performed for the Federal Aviation Administration (FAA) under the joint FAA-EUROCONTROL cooperative research Action Plan (AP-17), also known as the Future Communications Study (FCS). It was based on direction provided by the FAA project-level agreement (PLA FY09_G1M.02-02v1) for "New ATM Requirements-Future Communications." Task 7 was separated into two distinct subtasks, each aligned with specific work elements and deliverable items. Subtask 7-1 addressed C-band airport surface data communications standards development, systems engineering, test bed development, and tests/demonstrations to establish operational capability for what is now referred to as the Aeronautical Mobile Airport Communications System (AeroMACS). Subtask 7-2, which is the subject of this report, focused on preliminary systems engineering and support of joint FAA/EUROCONTROL development and evaluation of a future L-band (960 to 1164 MHz) air/ground (A/G) communication system known as the L-band digital aeronautical communications system (L-DACS), which was defined during the FCS. The proposed L-DACS will be capable of providing ATM services in continental airspace in the 2020+ timeframe. Subtask 7-2 was performed in two phases. Phase I featured development of Concepts of Use, high level functional analyses, performance of initial L-band system safety and security risk assessments, and development of high level requirements and architectures. It also included the aforementioned support of joint L-DACS development and evaluation, including inputs to L-DACS design specifications. Phase II provided a refinement of the systems engineering activities performed during Phase I, along with continued joint FAA/EUROCONTROL L-DACS development and evaluation support.

Structure and Content in Social Cognition: Conceptual and Empirical Analyses.

ERIC Educational Resources Information Center

Edelstein, Wolfgang; And Others

1984-01-01

Conceptual analysis of two perspective-taking tasks identified a number of subtasks calling for equivalent operations of social reasoning within tasks of different content. Subtasks hypothetically formed a logical and developmental sequence of abilities required for decentering. The developmental significance of the hierarchy was tested among 121…

Tree-based approach for exploring marine spatial patterns with raster datasets.

PubMed

Liao, Xiaohan; Xue, Cunjin; Su, Fenzhen

2017-01-01

From multiple raster datasets to spatial association patterns, the data-mining technique is divided into three subtasks, i.e., raster dataset pretreatment, mining algorithm design, and spatial pattern exploration from the mining results. Comparison with the former two subtasks reveals that the latter remains unresolved. Confronted with the interrelated marine environmental parameters, we propose a Tree-based Approach for eXploring Marine Spatial Patterns with multiple raster datasets called TAXMarSP, which includes two models. One is the Tree-based Cascading Organization Model (TCOM), and the other is the Spatial Neighborhood-based CAlculation Model (SNCAM). TCOM designs the "Spatial node→Pattern node" from top to bottom layers to store the table-formatted frequent patterns. Together with TCOM, SNCAM considers the spatial neighborhood contributions to calculate the pattern-matching degree between the specified marine parameters and the table-formatted frequent patterns and then explores the marine spatial patterns. Using the prevalent quantification Apriori algorithm and a real remote sensing dataset from January 1998 to December 2014, a successful application of TAXMarSP to marine spatial patterns in the Pacific Ocean is described, and the obtained marine spatial patterns present not only the well-known but also new patterns to Earth scientists.

IN SITU SOLID-PHASE EXTRACTION AND ANALYSIS OF ...

EPA Pesticide Factsheets

Fragrance materials, such as synthetic musks in aqueous samples, are normally analyzed by GC/MS in the selected ion monitoring (SIM) mode to provide maximum sensitivity after liquid-liquid extraction of 1-L samples. A 1-L sample, however, usually provides too little analyte for full-scan data acquisition.We have developed an on-site extraction method for extracting synthetic musks from 60 L of wastewater effluent. Such a large sample volume permits high-quality, full-scan mass spectra to be obtained for various synthetic musk compounds. Quantification of these compounds was conveniently achieved from the full-scan data directly, without preparing SIM descriptors for each compound to acquire SIM data. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-s

Expression and inheritance of sporophytic self-incompatibility in synthetic allohexaploid Senecio cambrensis (Asteraceae).

PubMed

Brennan, Adrian C; Hiscock, Simon J

2010-04-01

Allopolyploid speciation is common in plants and is frequently associated with shifts from outcrossing, for example self-incompatibility, to inbreeding (i.e. selfing). Senecio cambrensis is a recently evolved allohexaploid species that formed following hybridization between diploid self-incompatible S. squalidus and tetraploid self-compatible S. vulgaris. Studies of reproduction in wild populations of S. cambrensis have concluded that it is self-compatible. Here, we investigated self-compatibility in synthetic lines of S. cambrensis generated via hybridization and colchicine-induced polyploidization and wild S. cambrensis using controlled crossing experiments. Synthetic F(1)S. cambrensis individuals were all self-compatible but, in F(2) and later generations, self-incompatible individuals were identified at frequencies of 6.7-9.2%. Self-incompatibility was also detected in wild sampled individuals at a frequency of 12.2%. The mechanism and genetics of self-incompatibility were tested in synthetic S. cambrensis and found to be similar to those of its paternal parent S. squalidus (i.e. sporophytic). These results show, for the first time, that functional sporophytic self-incompatibility can be inherited and expressed in allopolyploids as early as the second (F(2)) generation. Wild S. cambrensis should therefore be considered as possessing a mixed mating system with the potential for evolution towards either inbreeding or outcrossing.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, Scott E.; Bruno, Kenneth S.; Butcher, Mark G.

In 2009, we continued to address barriers to fungal fermentation in the primary areas of morphology control, genomics, proteomics, fungal hyperproductivity, biomass-to-products via fungal based consolidated bioprocesses, and filamentous fungal ethanol. “Alternative renewable fuels from fungi” was added as a new subtask. Plans were also made to launch a new advanced strain development subtask in FY2010.

Small Engine Technology (SET) - Task 14 Axisymmetric Engine Simulation Environment

NASA Technical Reports Server (NTRS)

Miller, Max J.

1999-01-01

As part of the NPSS (Numerical Propulsion Simulation System) project, NASA Lewis has a goal of developing an U.S. industry standard for an axisymmetric engine simulation environment. In this program, AlliedSignal Engines (AE) contributed to this goal by evaluating the ENG20 software and developing support tools. ENG20 is a NASA developed axisymmetric engine simulation tool. The project was divided into six subtasks which are summarized below: Evaluate the capabilities of the ENG20 code using an existing test case to see how this procedure can capture the component interactions for a full engine. Link AE's compressor and turbine axisymmetric streamline curvature codes (UD0300M and TAPS) with ENG20, which will provide the necessary boundary conditions for an ENG20 engine simulation. Evaluate GE's Global Data System (GDS), attempt to use GDS to do the linking of codes described in Subtask 2 above. Use a turbofan engine test case to evaluate various aspects of the system, including the linkage of UD0300M and TAPS with ENG20 and the GE data storage system. Also, compare the solution results with cycle deck results, axisymmetric solutions (UD0300M and TAPS), and test data to determine the accuracy of the solution. Evaluate the order of accuracy and the convergence time for the solution. Provide a monthly status report and a final formal report documenting AE's evaluation of ENG20. Provide the developed interfaces that link UD0300M and TAPS with ENG20, to NASA. The interface that links UD0300M with ENG20 will be compatible with the industr,, version of UD0300M.

A computer-human interaction model to improve the diagnostic accuracy and clinical decision-making during 12-lead electrocardiogram interpretation.

PubMed

Cairns, Andrew W; Bond, Raymond R; Finlay, Dewar D; Breen, Cathal; Guldenring, Daniel; Gaffney, Robert; Gallagher, Anthony G; Peace, Aaron J; Henn, Pat

2016-12-01

The 12-lead Electrocardiogram (ECG) presents a plethora of information and demands extensive knowledge and a high cognitive workload to interpret. Whilst the ECG is an important clinical tool, it is frequently incorrectly interpreted. Even expert clinicians are known to impulsively provide a diagnosis based on their first impression and often miss co-abnormalities. Given it is widely reported that there is a lack of competency in ECG interpretation, it is imperative to optimise the interpretation process. Predominantly the ECG interpretation process remains a paper based approach and whilst computer algorithms are used to assist interpreters by providing printed computerised diagnoses, there are a lack of interactive human-computer interfaces to guide and assist the interpreter. An interactive computing system was developed to guide the decision making process of a clinician when interpreting the ECG. The system decomposes the interpretation process into a series of interactive sub-tasks and encourages the clinician to systematically interpret the ECG. We have named this model 'Interactive Progressive based Interpretation' (IPI) as the user cannot 'progress' unless they complete each sub-task. Using this model, the ECG is segmented into five parts and presented over five user interfaces (1: Rhythm interpretation, 2: Interpretation of the P-wave morphology, 3: Limb lead interpretation, 4: QRS morphology interpretation with chest lead and rhythm strip presentation and 5: Final review of 12-lead ECG). The IPI model was implemented using emerging web technologies (i.e. HTML5, CSS3, AJAX, PHP and MySQL). It was hypothesised that this system would reduce the number of interpretation errors and increase diagnostic accuracy in ECG interpreters. To test this, we compared the diagnostic accuracy of clinicians when they used the standard approach (control cohort) with clinicians who interpreted the same ECGs using the IPI approach (IPI cohort). For the control cohort, the (mean; standard deviation; confidence interval) of the ECG interpretation accuracy was (45.45%; SD=18.1%; CI=42.07, 48.83). The mean ECG interpretation accuracy rate for the IPI cohort was 58.85% (SD=42.4%; CI=49.12, 68.58), which indicates a positive mean difference of 13.4%. (CI=4.45, 22.35) An N-1 Chi-square test of independence indicated a 92% chance that the IPI cohort will have a higher accuracy rate. Interpreter self-rated confidence also increased between cohorts from a mean of 4.9/10 in the control cohort to 6.8/10 in the IPI cohort (p=0.06). Whilst the IPI cohort had greater diagnostic accuracy, the duration of ECG interpretation was six times longer when compared to the control cohort. We have developed a system that segments and presents the ECG across five graphical user interfaces. Results indicate that this approach improves diagnostic accuracy but with the expense of time, which is a valuable resource in medical practice. Copyright © 2016 Elsevier Inc. All rights reserved.

Classroom evaluation of the Arlyn Arm robotic workstation.

PubMed

Eberhardt, S P; Osborne, J; Rahman, T

2000-01-01

High school and junior high school students with neuromuscular weakness and other disorders of the arms evaluated a recently commercialized robotic workstation, the Arlyn Arm, to carry out art projects and science experiments. These tasks were designed for independent execution with the workstation using standard or custom-designed tools. Each task was divided into subtasks, and the execution time of each subtask was determined as a measure of efficiency. Special attention was given to the causes of required experimenter intervention. While subjects easily accomplished some subtasks, others required considerable intervention. Most of these interventions could be avoided by further customizing accessories. It is concluded that the Arlyn Arm workstation could be of considerable benefit in a classroom setting to persons with severe neuromuscular disorders.

78 FR 14013 - Medical Devices; Exemption From Premarket Notification; Class II Devices; Wheelchair Elevator

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-04

...: General Requirements for Safety-- Collateral Standard: Electromagnetic Compatibility--Requirements and... electromagnetic compatibility and electrical safety. Firms are now exempt from 510(k) requirements for vertical... Equipment--Part 1-2: General Requirements for Safety--Collateral Standard: Electromagnetic Compatibility...

Recent Advances in Clinical Natural Language Processing in Support of Semantic Analysis.

PubMed

Velupillai, S; Mowery, D; South, B R; Kvist, M; Dalianis, H

2015-08-13

We present a review of recent advances in clinical Natural Language Processing (NLP), with a focus on semantic analysis and key subtasks that support such analysis. We conducted a literature review of clinical NLP research from 2008 to 2014, emphasizing recent publications (2012-2014), based on PubMed and ACL proceedings as well as relevant referenced publications from the included papers. Significant articles published within this time-span were included and are discussed from the perspective of semantic analysis. Three key clinical NLP subtasks that enable such analysis were identified: 1) developing more efficient methods for corpus creation (annotation and de-identification), 2) generating building blocks for extracting meaning (morphological, syntactic, and semantic subtasks), and 3) leveraging NLP for clinical utility (NLP applications and infrastructure for clinical use cases). Finally, we provide a reflection upon most recent developments and potential areas of future NLP development and applications. There has been an increase of advances within key NLP subtasks that support semantic analysis. Performance of NLP semantic analysis is, in many cases, close to that of agreement between humans. The creation and release of corpora annotated with complex semantic information models has greatly supported the development of new tools and approaches. Research on non-English languages is continuously growing. NLP methods have sometimes been successfully employed in real-world clinical tasks. However, there is still a gap between the development of advanced resources and their utilization in clinical settings. A plethora of new clinical use cases are emerging due to established health care initiatives and additional patient-generated sources through the extensive use of social media and other devices.

Recent Advances in Clinical Natural Language Processing in Support of Semantic Analysis

PubMed Central

Mowery, D.; South, B. R.; Kvist, M.; Dalianis, H.

2015-01-01

Summary Objectives We present a review of recent advances in clinical Natural Language Processing (NLP), with a focus on semantic analysis and key subtasks that support such analysis. Methods We conducted a literature review of clinical NLP research from 2008 to 2014, emphasizing recent publications (2012-2014), based on PubMed and ACL proceedings as well as relevant referenced publications from the included papers. Results Significant articles published within this time-span were included and are discussed from the perspective of semantic analysis. Three key clinical NLP subtasks that enable such analysis were identified: 1) developing more efficient methods for corpus creation (annotation and de-identification), 2) generating building blocks for extracting meaning (morphological, syntactic, and semantic subtasks), and 3) leveraging NLP for clinical utility (NLP applications and infrastructure for clinical use cases). Finally, we provide a reflection upon most recent developments and potential areas of future NLP development and applications. Conclusions There has been an increase of advances within key NLP subtasks that support semantic analysis. Performance of NLP semantic analysis is, in many cases, close to that of agreement between humans. The creation and release of corpora annotated with complex semantic information models has greatly supported the development of new tools and approaches. Research on non-English languages is continuously growing. NLP methods have sometimes been successfully employed in real-world clinical tasks. However, there is still a gap between the development of advanced resources and their utilization in clinical settings. A plethora of new clinical use cases are emerging due to established health care initiatives and additional patient-generated sources through the extensive use of social media and other devices. PMID:26293867

ADDRESSING EMERGING ISSUES IN WATER QUALITY ...

EPA Pesticide Factsheets

Public concern over cleanliness and safety of source and recreational waters has prompted researchers to look for indicators of water quality. Giving public water authorities multiple tools to measure and monitor levels of chemical contaminants, as well as chemical markers of contamination, simply and rapidly would enhance public protection. The goals of water quality are outlined in the Water Quality Multi-year Plan [http://intranet.epa.gov/ospintra/Planning/wq.pdf] and the research in this task falls under GPRA Goal 2, 2.3.2, Long Term Goals 1, 2, and 4. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than parts per billion, ppb). IAG

Pressurized fluidized-bed hydroretorting of Eastern oil shales -- Sulfur control. Topical report for Subtask 3.1, In-bed sulfur capture tests; Subtask 3.2, Electrostatic desulfurization; Subtask 3.3, Microbial desulfurization and denitrification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, M.J.; Abbasian, J.; Akin, C.

1992-05-01

This topical report on ``Sulfur Control`` presents the results of work conducted by the Institute of Gas Technology (IGT), the Illinois Institute of Technology (IIT), and the Ohio State University (OSU) to develop three novel approaches for desulfurization that have shown good potential with coal and could be cost-effective for oil shales. These are (1) In-Bed Sulfur Capture using different sorbents (IGT), (2) Electrostatic Desulfurization (IIT), and (3) Microbial Desulfurization and Denitrification (OSU and IGT). The objective of the task on In-Bed Sulfur Capture was to determine the effectiveness of different sorbents (that is, limestone, calcined limestone, dolomite, and siderite)more » for capturing sulfur (as H{sub 2}S) in the reactor during hydroretorting. The objective of the task on Electrostatic Desulfurization was to determine the operating conditions necessary to achieve a high degree of sulfur removal and kerogen recovery in IIT`s electrostatic separator. The objectives of the task on Microbial Desulfurization and Denitrification were to (1) isolate microbial cultures and evaluate their ability to desulfurize and denitrify shale, (2) conduct laboratory-scale batch and continuous tests to improve and enhance microbial removal of these components, and (3) determine the effects of processing parameters, such as shale slurry concentration, solids settling characteristics, agitation rate, and pH on the process.« less

Angular distributions in the reactions pp-->χ1,2-->γψ-->γe+e-

NASA Astrophysics Data System (ADS)

Baglin, C.; Baird, S.; Bassompierre, G.; Borreani, G.; Brient, J.-C.; Broll, C.; Brom, J.-M.; Bugge, L.; Buran, T.; Burq, J.-P.; Bussière, A.; Buzzo, A.; Cester, R.; Chemarin, M.; Chevallier, M.; Escoubes, B.; Fay, J.; Ferroni, S.; Gracco, V.; Guillad, J.-P.; Khan-Aronsen, E.; Kirsebom, K.; Kylling, A.; Ille, B.; Lambert, M.; Leistam, L.; Lundby, A.; Macri, M.; Marchetto, F.; Menichetti, E.; Morch, C.; Mouëllic, B.; Olsen, D.; Pastrone, N.; Petrillo, L.; Pia, M. G.; Poole, J.; Poulet, M.; Rinaudo, G.; Santroni, A.; Severi, M.; Skjevling, G.; Stugu, B.

1987-08-01

In the experiment R704 at the CERN Intersecting Storage Rings, the two p-wave charmonium states χ1 and χ2 were formed directly in proton-antiproton annihilation, and detected through the decay chain χj-->γ+J/ψ-->ψ+e+e-. The angular d istributions of the events found are studied here. A maximum likehood analysis shows that χ1 radiative transition to the J/ψ is compatible with a pure dipole. Indications of a nonzero, positive quadropole contribution to the χ2 radiative transition are found. Finally, it is found that the χ2 data are consistent with the conventional assumption that a single quark radiates the photon in the transition from the χ2 to the J/ψ.

Spatiotemporal and Kinematic Parameters Relating to Oriented Gait and Turn Performance in Patients with Chronic Stroke

PubMed Central

Bonnyaud, Céline; Pradon, Didier; Vuillerme, Nicolas; Bensmail, Djamel; Roche, Nicolas

2015-01-01

Background The timed up and go test (TUG) is a functional test which is increasingly used to evaluate patients with stroke. The outcome measured is usually global TUG performance-time. Assessment of spatiotemporal and kinematic parameters during the Oriented gait and Turn sub-tasks of the TUG would provide a better understanding of the mechanisms underlying patients’ performance and therefore may help to guide rehabilitation. The aim of this study was thus to determine the spatiotemporal and kinematic parameters which were most related to the walking and turning sub-tasks of TUG performance in stroke patients. Methods 29 stroke patients carried out the TUG test which was recorded using an optoelectronic system in two conditions: spontaneous and standardized condition (standardized foot position and instructed to turn towards the paretic side). They also underwent a clinical assessment. Stepwise regression was used to determine the parameters most related to Oriented gait and Turn sub-tasks. Relationships between explanatory parameters of Oriented gait and Turn performance and clinical scales were evaluated using Spearman correlations. Results Step length and cadence explained 82% to 95% of the variance for the walking sub-tasks in both conditions. Percentage single support phase and contralateral swing phase (depending on the condition) respectively explained 27% and 56% of the variance during the turning sub-task in the spontaneous and standardized conditions. Discussion and Conclusion Step length, cadence, percentage of paretic single support phase and non-paretic swing phase, as well as dynamic stability were the main parameters related to TUG performance and they should be targeted in rehabilitation. PMID:26091555

Compatibility of 2, 4, 6, 8, 10,12-Hexanitrohexaazaisowurtzitane with a Selection of Insensitive Explosives

NASA Astrophysics Data System (ADS)

Li, Xi; Lin, Qiu-han; Zhao, Xin-Ying; Han, Zhi-Wei; Wang, Bo-liang

2017-04-01

Thermal techniques (differential scanning calorimetry (DSC) and the vacuum stability test (VST)), according to STANAG 4147, and non-thermal techniques (Fourier transform infrared (FTIR) spectrometry and X-ray diffractometry (XRD)) were used to examine compatibility issues for 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (CL-20) with a selection of insensitive explosives, including nitroguanidine (NQ), 2,4,6-trinitrotoluene (TNT), 2,6-diamino-3,5-dinitropyridine-1-oxide (ANPyO), 2,4,6-triamino-1,3,5-trinitrobenzene (TATB), 3-nitro-1,2,4-triazol-5-one (NTO) and 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105). DSC measurements showed that ANPyO, TATB, NTO and LLM-105 were compatible with CL-20. The compatibility of CL-20/NQ, CL-20/TNT, CL-20/ANPyO, CL-20/TATB, CL-20/NTO and CL-20/LLM-105 mixtures was further explored using the VST, which revealed that all the selected insensitive explosives were compatible with CL-20. Possible chemical interactions were suspected for CL-20/TATB from the FTIR results and for CL-20/NTO from XRD analysis. In summary, ANPyO and LLM-105 demonstrated the optimal compatibility with CL-20.

Earth resources data analysis program, phase 2

NASA Technical Reports Server (NTRS)

1974-01-01

The efforts and findings of the Earth Resources Data Analysis Program are summarized. Results of a detailed study of the needs of EOD with respect to an applications development system (ADS) for the analysis of remotely sensed data, including an evaluation of four existing systems with respect to these needs are described. Recommendations as to possible courses for EOD to follow to obtain a viable ADS are presented. Algorithmic development comprised of several subtasks is discussed. These subtasks include the following: (1) two algorithms for multivariate density estimation; (2) a data smoothing algorithm; (3) a method for optimally estimating prior probabilities of unclassified data; and (4) further applications of the modified Cholesky decomposition in various calculations. Little effort was expended on task 3, however, two reports were reviewed.

Individual muscle contributions to push and recovery subtasks during wheelchair propulsion.

PubMed

Rankin, Jeffery W; Richter, W Mark; Neptune, Richard R

2011-04-29

Manual wheelchair propulsion places considerable physical demand on the upper extremity and is one of the primary activities associated with the high prevalence of upper extremity overuse injuries and pain among wheelchair users. As a result, recent effort has focused on determining how various propulsion techniques influence upper extremity demand during wheelchair propulsion. However, an important prerequisite for identifying the relationships between propulsion techniques and upper extremity demand is to understand how individual muscles contribute to the mechanical energetics of wheelchair propulsion. The purpose of this study was to use a forward dynamics simulation of wheelchair propulsion to quantify how individual muscles deliver, absorb and/or transfer mechanical power during propulsion. The analysis showed that muscles contribute to either push (i.e., deliver mechanical power to the handrim) or recovery (i.e., reposition the arm) subtasks, with the shoulder flexors being the primary contributors to the push and the shoulder extensors being the primary contributors to the recovery. In addition, significant activity from the shoulder muscles was required during the transition between push and recovery, which resulted in increased co-contraction and upper extremity demand. Thus, strengthening the shoulder flexors and promoting propulsion techniques that improve transition mechanics have much potential to reduce upper extremity demand and improve rehabilitation outcomes. Copyright © 2011 Elsevier Ltd. All rights reserved.

Simulating Bilayers of Nonionic Surfactants with the GROMOS-Compatible 2016H66 Force Field.

PubMed

Senac, Caroline; Urbach, Wladimir; Kurtisovski, Erol; Hünenberger, Philippe H; Horta, Bruno A C; Taulier, Nicolas; Fuchs, Patrick F J

2017-10-03

Polyoxyethylene glycol alkyl ether amphiphiles (C i E j ) are important nonionic surfactants, often used for biophysical and membrane protein studies. In this work, we extensively test the GROMOS-compatible 2016H66 force field in molecular dynamics simulations involving the lamellar phase of a series of C i E j surfactants, namely C 12 E 2 , C 12 E 3 , C 12 E 4 , C 12 E 5 , and C 14 E 4 . The simulations reproduce qualitatively well the monitored structural properties and their experimental trends along the surfactant series, although some discrepancies remain, in particular in terms of the area per surfactant, the equilibrium phase of C 12 E 5 , and the order parameters of C 12 E 3 , C 12 E 4 , and C 12 E 5 . The polar head of the C i E j surfactants is highly hydrated, almost like a single polyethyleneoxide (PEO) molecule at full hydration, resulting in very compact conformations. Within the bilayer, all C i E j surfactants flip-flop spontaneously within tens of nanoseconds. Water-permeation is facilitated, and the bending rigidity is 4 to 5 times lower than that of typical phospholipid bilayers. In line with another recent theoretical study, the simulations show that the lamellar phase of C i E j contains large hydrophilic pores. These pores should be abundant in order to reproduce the comparatively low NMR order parameters. We show that their contour length is directly correlated to the order parameters, and we estimate that they should occupy approximately 7-10% of the total membrane area. Due to their highly dynamic nature (rapid flip-flops, high water permeability, observed pore formation), C i E j surfactant bilayers are found to represent surprisingly challenging systems in terms of modeling. Given this difficulty, the results presented here show that the 2016H66 parameters, optimized independently considering pure-liquid as well as polar and nonpolar solvation properties of small organic molecules, represent a good starting point for simulating these systems.

Analysis of traffic growth rates

DOT National Transportation Integrated Search

2001-08-01

The primary objectives of this study were to determine patterns of traffic flow and develop traffic growth rates by traffic composition and highway type for Kentucky's system of highways. Additional subtasks included the following: 1) a literature se...

Smart roadside initiative gap analysis : trucking technology utilization.

DOT National Transportation Integrated Search

2014-04-01

This technical memorandum synthesizes and summarizes the American Transportation Research Institutes (ATRI) findings for Subtask 2.3 of the Smart Roadside Initiative (SRI) Gap Analysis. As part of this task, ATRI: 1. completed a technical literatu...

ENVIRONMENTAL STEWARDSHIP OF PHARMACEUTICALS ...

EPA Pesticide Factsheets

The occurrence of pharmaceuticals and personal care products (PPCPS) as environmental pollutants is a multifaceted issue whose scope continues to become better delineated since the escalation of conceited attention beginning in the 1980s. PPCPs typically occur as trace environmental pollutants (primarily in surface but also in ground waters) as a result of their widespread, continuous, combined usage in a broad range of human and veterinary therapeutic activities and practices. With respect to the risk-assessment paradigm the growing body of published work has focused primarily on the origin and occurrence of these substances. Comparatively less is known about human and ecological exposure, and even less about the documented or potential hazards associated with trace exposure to these anthropogenic substances, many of which are highly bioactive and perpetually present in many aquatic locales. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/m

MERCURY MEASUREMENTS USING DIRECT-ANALYZER ...

EPA Pesticide Factsheets

Under EPA's Water Quality Research Program, exposure studies are needed to determine how well control strategies and guidance are working. Consequently, reliable and convenient techniques that minimize waste production are of special interest. While traditional methods for determining mercury in solid samples involve the use of aggressive chemicals to dissolve the matrix and the use of other chemicals to properly reduce the mercury to the volatile elemental form, pyrolysis-based analyzers can be used by directly weighing the solid in a sampling boat and initiating the instrumental analysis for total mercury. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at con

Multitasking 3-D forward modeling using high-order finite difference methods on the Cray X-MP/416

DOE Office of Scientific and Technical Information (OSTI.GOV)

Terki-Hassaine, O.; Leiss, E.L.

1988-01-01

The CRAY X-MP/416 was used to multitask 3-D forward modeling by the high-order finite difference method. Flowtrace analysis reveals that the most expensive operation in the unitasked program is a matrix vector multiplication. The in-core and out-of-core versions of a reentrant subroutine can perform any fraction of the matrix vector multiplication independently, a pattern compatible with multitasking. The matrix vector multiplication routine can be distributed over two to four processors. The rest of the program utilizes the microtasking feature that lets the system treat independent iterations of DO-loops as subtasks to be performed by any available processor. The availability ofmore » the Solid-State Storage Device (SSD) meant the I/O wait time was virtually zero. A performance study determined a theoretical speedup, taking into account the multitasking overhead. Multitasking programs utilizing both macrotasking and microtasking features obtained actual speedups that were approximately 80% of the ideal speedup.« less

Mechanical flexible joint design document

NASA Technical Reports Server (NTRS)

Daily, Vic

1993-01-01

The purpose of this report is to document the status of the Mechanical Flexible Joint (MFJ) Design Subtask with the intent of halting work on the design. Recommendations for future work is included in the case that the task is to be resumed. The MFJ is designed to eliminate two failure points from the current flex joint configuration, the inner 'tripod configuration' and the outer containment jacket. The MFJ will also be designed to flex 13.5 degrees and have three degrees of freedom. By having three degrees of freedom, the MFJ will allow the Low Pressure Fuel Duct to twist and remove the necessity to angulate the full 11 degrees currently required. The current flex joints are very labor intensive and very costly and a simple alternative is being sought. The MFJ is designed with a greater angular displacement, with three degrees of freedom, to reside in the same overall envelope, to meet weight constraints of the current bellows, to be compatible with cryogenic fuel and oxidizers, and also to be man-rated.

Physical risk factors identification based on body sensor network combined to videotaping.

PubMed

Vignais, Nicolas; Bernard, Fabien; Touvenot, Gérard; Sagot, Jean-Claude

2017-11-01

The aim of this study was to perform an ergonomic analysis of a material handling task by combining a subtask video analysis and a RULA computation, implemented continuously through a motion capture system combining inertial sensors and electrogoniometers. Five workers participated to the experiment. Seven inertial measurement units, placed on the worker's upper body (pelvis, thorax, head, arms, forearms), were implemented through a biomechanical model of the upper body to continuously provide trunk, neck, shoulder and elbow joint angles. Wrist joint angles were derived from electrogoniometers synchronized with the inertial measurement system. Worker's activity was simultaneously recorded using video. During post-processing, joint angles were used as inputs to a computationally implemented ergonomic evaluation based on the RULA method. Consequently a RULA score was calculated at each time step to characterize the risk of exposure of the upper body (right and left sides). Local risk scores were also computed to identify the anatomical origin of the exposure. Moreover, the video-recorded work activity was time-studied in order to classify and quantify all subtasks involved into the task. Results showed that mean RULA scores were at high risk for all participants (6 and 6.2 for right and left sides respectively). A temporal analysis demonstrated that workers spent most part of the work time at a RULA score of 7 (right: 49.19 ± 35.27%; left: 55.5 ± 29.69%). Mean local scores revealed that most exposed joints during the task were elbows, lower arms, wrists and hands. Elbows and lower arms were indeed at a high level of risk during the total time of a work cycle (100% for right and left sides). Wrist and hands were also exposed to a risky level for much of the period of work (right: 82.13 ± 7.46%; left: 77.85 ± 12.46%). Concerning the subtask analysis, subtasks called 'snow thrower', 'opening the vacuum sealer', 'cleaning' and 'storing' have been identified as the most awkward for right and left sides given mean RULA scores and percentages of time spent at risky levels. Results analysis permitted to suggest ergonomic recommendations for the redesign of the workstation. Contributions of the proposed innovative system dedicated to physical ergonomic assessment are further discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical compatibility study between ceramic breeder and EUROFER97 steel for HCPB-DEMO blanket

NASA Astrophysics Data System (ADS)

Mukai, Keisuke; Sanchez, Fernando; Knitter, Regina

2017-05-01

Chemical compatibility between ceramic breeder (Li4SiO4 + 20 mol% addition of Li2TiO3) and EUROFER97 steel was examined in this study. These materials were contacted and heated at 623, 823 and 1073 K under He + 0.1 vol.% H2 atmosphere for up to 12 weeks. Limited influence was found in the breeder specimens, although losses of the constituent elements appeared near the surface of the breeder pellets heated at 1073 K. For the EUROFER specimens with formation of a corrosion layer, element diffusivity was estimated based on diffusion kinetics. In the temperature range, effective diffusion coefficients of oxygen into EUROFER steel were in the range from 3.5 × 10-14 to 2.5 × 10-12 cm2/s and found to be faster than that of Li. The coefficients yielded an activation energy of 0.93 eV for oxygen diffusion into EUROFER steel and predicted the possible thickness of the corrosion layer after operational periods.

A Hybrid Method for Opinion Finding Task (KUNLP at TREC 2008 Blog Track)

DTIC Science & Technology

2008-11-01

retrieve relevant documents. For the Opinion Retrieval subtask, we propose a hybrid model of lexicon-based approach and machine learning approach for...estimating and ranking the opinionated documents. For the Polarized Opinion Retrieval subtask, we employ machine learning for predicting the polarity...and linear combination technique for ranking polar documents. The hybrid model which utilize both lexicon-based approach and machine learning approach

Information Presentation

NASA Technical Reports Server (NTRS)

Holden, Kritina L.; Thompson, Shelby G.; Sandor, Aniko; McCann, Robert S.; Kaiser, Mary K.; Adelstein, Barnard D.; Begault, Durand R.; Beutter, Brent R.; Stone, Leland S.; Godfroy, Martine

2009-01-01

The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. In addition to addressing display design issues associated with information formatting, style, layout, and interaction, the Information Presentation DRP is also working toward understanding the effects of extreme environments encountered in space travel on information processing. Work is also in progress to refine human factors-based design tools, such as human performance modeling, that will supplement traditional design techniques and help ensure that optimal information design is accomplished in the most cost-efficient manner. The major areas of work, or subtasks, within the Information Presentation DRP for FY10 are: 1) Displays, 2) Controls, 3) Procedures and Fault Management, and 4) Human Performance Modeling. The poster will highlight completed and planned work for each subtask.

The compatibility heuristic in non-categorical hypothetical reasoning: inferences between conditionals and disjunctions.

PubMed

Espino, Orlando; Byrne, Ruth M J

2013-11-01

A new theory explains how people make hypothetical inferences from a premise consistent with several alternatives to a conclusion consistent with several alternatives. The key proposal is that people rely on a heuristic that identifies compatible possibilities. It is tested in 7 experiments that examine inferences between conditionals and disjunctions. Participants accepted inferences between conditionals and inclusive disjunctions when a compatible possibility was immediately available, in their binary judgments that a conclusion followed or not (Experiment 1a) and ternary judgments that included it was not possible to know (Experiment 1b). The compatibility effect was amplified when compatible possibilities were more readily available, e.g., for 'A only if B' conditionals (Experiment 2). It was eliminated when compatible possibilities were not available, e.g., for 'if and only if A B' bi-conditionals and exclusive disjunctions (Experiment 3). The compatibility heuristic occurs even for inferences based on implicit negation e.g., 'A or B, therefore if C D' (Experiment 4), and between universals 'All A's are B's' and disjunctions (Experiment 5a) and universals and conditionals (Experiment 5b). The implications of the results for alternative theories of the cognitive processes underlying hypothetical deductions are discussed. Copyright © 2013. Published by Elsevier Inc.

Episodic-like memory trace in awake replay of hippocampal place cell activity sequences.

PubMed

Takahashi, Susumu

2015-10-20

Episodic memory retrieval of events at a specific place and time is effective for future planning. Sequential reactivation of the hippocampal place cells along familiar paths while the animal pauses is well suited to such a memory retrieval process. It is, however, unknown whether this awake replay represents events occurring along the path. Using a subtask switching protocol in which the animal experienced three subtasks as 'what' information in a maze, I here show that the replay represents a trial type, consisting of path and subtask, in terms of neuronal firing timings and rates. The actual trial type to be rewarded could only be reliably predicted from replays that occurred at the decision point. This trial-type representation implies that not only 'where and when' but also 'what' information is contained in the replay. This result supports the view that awake replay is an episodic-like memory retrieval process.

HfSe2 and ZrSe2: Two-dimensional semiconductors with native high-κ oxides

PubMed Central

Mleczko, Michal J.; Zhang, Chaofan; Lee, Hye Ryoung; Kuo, Hsueh-Hui; Magyari-Köpe, Blanka; Moore, Robert G.; Shen, Zhi-Xun; Fisher, Ian R.; Nishi, Yoshio; Pop, Eric

2017-01-01

The success of silicon as a dominant semiconductor technology has been enabled by its moderate band gap (1.1 eV), permitting low-voltage operation at reduced leakage current, and the existence of SiO2 as a high-quality “native” insulator. In contrast, other mainstream semiconductors lack stable oxides and must rely on deposited insulators, presenting numerous compatibility challenges. We demonstrate that layered two-dimensional (2D) semiconductors HfSe2 and ZrSe2 have band gaps of 0.9 to 1.2 eV (bulk to monolayer) and technologically desirable “high-κ” native dielectrics HfO2 and ZrO2, respectively. We use spectroscopic and computational studies to elucidate their electronic band structure and then fabricate air-stable transistors down to three-layer thickness with careful processing and dielectric encapsulation. Electronic measurements reveal promising performance (on/off ratio > 106; on current, ~30 μA/μm), with native oxides reducing the effects of interfacial traps. These are the first 2D materials to demonstrate technologically relevant properties of silicon, in addition to unique compatibility with high-κ dielectrics, and scaling benefits from their atomically thin nature. PMID:28819644

Go Team Experimentation Results: Research, Train and Sustain. Human Dimensions of NCW Sub-Task Report

DTIC Science & Technology

2008-10-01

it is necessary to foster a culture of cooperative behaviour in a competitive environment (i.e. ‘ co - opetition ’, as defined by Angehrn and Loebbecke...Source Communities Reflecting Co - opetitive Learning and Knowledge Exchange Networks”, Proceedings of DSS 2004, Prato, Italy Ashby W. R. (1957) An...This is often counter to the existing organisational culture and some social learning (Warne et al 2003) is required before ‘ co -opetive’ behaviour

Intelligent Engine Systems Work Element 1.3: Sub System Health Management

NASA Technical Reports Server (NTRS)

Ashby, Malcolm; Simpson, Jeffrey; Singh, Anant; Ferguson, Emily; Frontera, mark

2005-01-01

The objectives of this program were to develop health monitoring systems and physics-based fault detection models for engine sub-systems including the start, lubrication, and fuel. These models will ultimately be used to provide more effective sub-system fault identification and isolation to reduce engine maintenance costs and engine down-time. Additionally, the bearing sub-system health is addressed in this program through identification of sensing requirements, a review of available technologies and a demonstration of a demonstration of a conceptual monitoring system for a differential roller bearing. This report is divided into four sections; one for each of the subtasks. The start system subtask is documented in section 2.0, the oil system is covered in section 3.0, bearing in section 4.0, and the fuel system is presented in section 5.0.

ON-SITE SOLID PHRASE EXTRACTION AND LABORATORY ...

EPA Pesticide Factsheets

Fragrance materials, such as synthetic musks in aqueous samples, are normally analyzed by GC/MS in the selected ion monitoring (SIM) mode to provide maximum sensitivity after liquid-liquid extraction of I -L samples. A I -L sample, however, usually provides too little analyte for full-scan data acquisition. An on-site extraction method for extracting synthetic musks from 60 L of wastewater effluent has been developed. Such a large sample volume permits high-quality, full-scan mass spectra to be obtained for various synthetic musk compounds. Quantification of these compounds was conveniently achieved from the full-scan data directly, without preparing SIM descriptors for each compound to acquire SIM data. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-sol

ANALYTICAL CHEMISTRY RESEARCH NEEDS FOR ...

EPA Pesticide Factsheets

The consensus among environmental scientists and risk assessors is that the fate and effects of pharmaceutical and personal care products (PPCPS) in the environment are poorly understood. Many classes of PPCPs have yet to be investigated. Acquisition of trends data for a suite of PPCPs (representatives from each of numerous significant classes), shown to recur amongst municipal wastewater treatment plants across the country, may prove of key importance. The focus of this paper is an overview of some of the analytical methods being developed at the Environmenental Protection Agency and their application to wastewater and surface water samples. Because PPCPs are generally micro-pollutants, emphasis is on development of enrichment and pre- concentration techniques using various means of solid-phase extraction. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCP

LEVELS OF SYNTHETIC MUSKS COMPOUNDS IN AQUATIC ...

EPA Pesticide Factsheets

Synthetic musk compounds are consumer chemicals manufactured as fragrance materials Due to their high worldwide usage and release, they frequently occur in the aquatic and marine environments. The U.S. EPA (ORD, Las Vegas) developed surface-water monitoring methodology and conducted a one-year monthly monitoring of synthetic musks in water and biota from Lake Mead (Nevada) as well as from combined sewage effluent streams feeding Lake Mead. Presented are the overview of the chemistry, the monitoring methodology, and the significance of synthetic musk compounds in the aquatic environment. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spectrometry) and apply them to studying the sources and fate of a select list of PPCPs. Application and improvement of analytical methodologies that can detect non-volatile, polar, water-soluble pharmaceuticals in source waters at levels that could be environmentally significant (at concentrations less than p

DETERMINATION ROXARSONE AND ITS ...

EPA Pesticide Factsheets

Roxarsone (3-nitro-4-hydroxyphenyl-arsonic acid) is one of the most widely used growthpromoting and disease-controlling feed additives in the United States. Most broiler chickens are fed roxarsone to promote weight gain and control parasites. Most of the roxarsone is believed to be excreted unchanged, and the resulting arsenic-containing waste is commonly recycled as fertilizer. Once in the environment, roxarsone can easily degrade into much more mobile and toxic arsenic (As) species. While HPLC coupled to ICP-MS has been used for the determination of As species including roxarsone degradation products, it is limited in its resolution. Capillary electrophoresis (CE) has the advantages of simple hardware and high efficiency. When coupled with ICP-MS for detection, CE-ICP-MS can provide a sensitive, highly selective method for the determination of roxarsone and its transformation products. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers, advanced solid-phase extraction methodologies with liquid chromatography/electrospray/mass spec

Extracellular domains play different roles in gap junction formation and docking compatibility.

PubMed

Bai, Donglin; Wang, Ao Hong

2014-02-15

GJ (gap junction) channels mediate direct intercellular communication and play an important role in many physiological processes. Six connexins oligomerize to form a hemichannel and two hemichannels dock together end-to-end to form a GJ channel. Connexin extracellular domains (E1 and E2) have been shown to be important for the docking, but the molecular mechanisms behind the docking and formation of GJ channels are not clear. Recent developments in atomic GJ structure and functional studies on a series of connexin mutants revealed that E1 and E2 are likely to play different roles in the docking. Non-covalent interactions at the docking interface, including hydrogen bonds, are predicted to form between interdocked extracellular domains. Protein sequence alignment analysis on the docking compatible/incompatible connexins indicate that the E1 domain is important for the formation of the GJ channel and the E2 domain is important in the docking compatibility in heterotypic channels. Interestingly, the hydrogen-bond forming or equivalent residues in both E1 and E2 domains are mutational hot spots for connexin-linked human diseases. Understanding the molecular mechanisms of GJ docking can assist us to develop novel strategies in rescuing the disease-linked connexin mutants.

Sample data from a Distributed Acoustic Sensing experiment at Garner Valley, California (PoroTomo Subtask 3.2)

DOE Data Explorer

Lancelle, Chelsea

2013-09-10

In September 2013, an experiment using Distributed Acoustic Sensing (DAS) was conducted at Garner Valley, a test site of the University of California Santa Barbara (Lancelle et al., 2014). This submission includes one 45 kN shear shaker (called “large shaker” on the basemap) test for three different measurement systems. The shaker swept from a rest, up to 10 Hz, and back down to a rest over 60 seconds. Lancelle, C., N. Lord, H. Wang, D. Fratta, R. Nigbor, A. Chalari, R. Karaulanov, J. Baldwin, and E. Castongia (2014), Directivity and Sensitivity of Fiber-Optic Cable Measuring Ground Motion using a Distributed Acoustic Sensing Array (abstract # NS31C-3935), AGU Fall Meeting. https://agu.confex.com/agu/fm1/meetingapp.cgi#Paper/19828 The e-poster is available at: https://agu.confex.com/data/handout/agu/fm14/Paper_19828_handout_696_0.pdf

Resource-Aware Mobile-Based Health Monitoring.

PubMed

Masud, Mohammad M; Adel Serhani, Mohamed; Navaz, Alramzana Nujum

2017-03-01

Monitoring heart diseases often requires frequent measurements of electrocardiogram (ECG) signals at different periods of the day, and at different situations (e.g., traveling, and exercising). This can only be implemented using mobile devices in order to cope with mobility of patients under monitoring, thus supporting continuous monitoring practices. However, these devices are energy-aware, have limited computing resources (e.g., CPU speed and memory), and might lose network connectivity, which makes it very challenging to maintain a continuity of the monitoring episode. In this paper, we propose a mobile monitoring solution to cope with these challenges by compromising on the fly resources availability, battery level, and network intermittence. In order to solve this problem, first we divide the whole process into several subtasks such that each subtask can be executed sequentially either in the server or in the mobile or in parallel in both devices. Then, we developed a mathematical model that considers all the constraints and finds a dynamic programing solution to obtain the best execution path (i.e., which substep should be done where). The solution guarantees an optimum execution time, while considering device battery availability, execution and transmission time, and network availability. We conducted a series of experiments to evaluate our proposed approach using some key monitoring tasks starting from preprocessing to classification and prediction. The results we have obtained proved that our approach gives the best (lowest) running time for any combination of factors including processing speed, input size, and network bandwidth. Compared to several greedy but nonoptimal solutions, the execution time of our approach was at least 10 times faster and consumed 90% less energy.

Medium-Bandgap Small-Molecule Donors Compatible with Both Fullerene and Nonfullerene Acceptors.

PubMed

Huo, Yong; Yan, Cenqi; Kan, Bin; Liu, Xiao-Fei; Chen, Li-Chuan; Hu, Chen-Xia; Lau, Tsz-Ki; Lu, Xinhui; Sun, Chun-Lin; Shao, Xiangfeng; Chen, Yongsheng; Zhan, Xiaowei; Zhang, Hao-Li

2018-03-21

Much effort has been devoted to the development of new donor materials for small-molecule organic solar cells due to their inherent advantages of well-defined molecular weight, easy purification, and good reproducibility in photovoltaic performance. Herein, we report two small-molecule donors that are compatible with both fullerene and nonfullerene acceptors. Both molecules consist of an (E)-1,2-di(thiophen-2-yl)ethane-substituted (TVT-substituted) benzo[1,2-b:4,5-b']dithiophene (BDT) as the central unit, and two rhodanine units as the terminal electron-withdrawing groups. The central units are modified with either alkyl side chains (DRBDT-TVT) or alkylthio side chains (DRBDT-STVT). Both molecules exhibit a medium bandgap with complementary absorption and proper energy level offset with typical acceptors like PC 71 BM and IDIC. The optimized devices show a decent power conversion efficiency (PCE) of 6.87% for small-molecule organic solar cells and 6.63% for nonfullerene all small-molecule organic solar cells. Our results reveal that rationally designed medium-bandgap small-molecule donors can be applied in high-performance small-molecule organic solar cells with different types of acceptors.

Electronic toll collection interoperability study in Brazil. Task 4 : recommendations and final report

DOT National Transportation Integrated Search

1998-05-01

The report examines the potential for developing electronic toll collection systems in Brazil. This is Volume III and it is 'Task-Recommendations and Final Report'. The report is made up of the following subtasks: (1) Issue Recommended Installation S...

Subtask 7.1 - Strategic Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas Erickson

2009-03-30

The Energy & Environmental Research Center (EERC) has recently completed 11 years of research through the Cooperative Agreement with the U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL) focused on fossil energy technology development and demonstration. To support a significant number of the different activities being considered within all of our research contracts with NETL, a subtask (7.1 Strategic Studies) was created to focus on small research efforts that came up throughout the year which would support an existing EERC-NETL project or would help to develop a new concept for inclusion in future efforts. Typical efforts conducted undermore » this task were usually between $15,000 and $60,000 in scope and had time lines of less than 6 months. A limited number of larger studies were also conducted, generally at the direct request of NETL. Over the life of this task, 46 projects were conducted. These efforts ranged from quick experiments to gain fundamental knowledge to support a current effort, to literature reviews, to a few larger engineering efforts.« less

An Investigation into the Nature of Non-Voiding Contractions Resulting from Detrusor Hyperreflexia in Neurogenic Bladders Following Spinal Cord Injury

DTIC Science & Technology

2015-06-01

occasioned by numerous, rhythmic high pressure non-voiding contractions (NVC) during normal bladder filling. These NVC are responsible for incontinence...month experiment period) 2c. Final data analysis (data analysis will be ongoing throughout, this will represent the finalization of data period, 0.25...Sub-Tasks 2a and 2b. As of 9/2/14, we have completed much of the data analysis (Sub-Task 2c; see below for results). Analysis of abdominal

A robust data-driven approach for gene ontology annotation.

PubMed

Li, Yanpeng; Yu, Hong

2014-01-01

Gene ontology (GO) and GO annotation are important resources for biological information management and knowledge discovery, but the speed of manual annotation became a major bottleneck of database curation. BioCreative IV GO annotation task aims to evaluate the performance of system that automatically assigns GO terms to genes based on the narrative sentences in biomedical literature. This article presents our work in this task as well as the experimental results after the competition. For the evidence sentence extraction subtask, we built a binary classifier to identify evidence sentences using reference distance estimator (RDE), a recently proposed semi-supervised learning method that learns new features from around 10 million unlabeled sentences, achieving an F1 of 19.3% in exact match and 32.5% in relaxed match. In the post-submission experiment, we obtained 22.1% and 35.7% F1 performance by incorporating bigram features in RDE learning. In both development and test sets, RDE-based method achieved over 20% relative improvement on F1 and AUC performance against classical supervised learning methods, e.g. support vector machine and logistic regression. For the GO term prediction subtask, we developed an information retrieval-based method to retrieve the GO term most relevant to each evidence sentence using a ranking function that combined cosine similarity and the frequency of GO terms in documents, and a filtering method based on high-level GO classes. The best performance of our submitted runs was 7.8% F1 and 22.2% hierarchy F1. We found that the incorporation of frequency information and hierarchy filtering substantially improved the performance. In the post-submission evaluation, we obtained a 10.6% F1 using a simpler setting. Overall, the experimental analysis showed our approaches were robust in both the two tasks. © The Author(s) 2014. Published by Oxford University Press.

Identification of G-Protein-Coupled Receptors (GPCRs) in Pulmonary Artery Smooth Muscle Cells as Novel Therapeutic Targets

DTIC Science & Technology

2017-10-01

available pharmacological agents (in particular, for which FDA-approved drugs exist) and that we predict have a pathophysiological impact. The Sub-tasks...on the responses to a known receptor agonist. To be completed by 8/2018.   3e. Pending results of studies in Sub-tasks 2-4, test ability of drugs ...cardiac and lung fibroblasts as possible drug targets for tissue fibrosis. R21AG053568 (PI: P. Insel) 9/30/2016-4/30/2018

Resolving the Extragalactic γ-Ray Background above 50 GeV with the Fermi Large Area Telescope.

PubMed

Ackermann, M; Ajello, M; Albert, A; Atwood, W B; Baldini, L; Ballet, J; Barbiellini, G; Bastieri, D; Bechtol, K; Bellazzini, R; Bissaldi, E; Blandford, R D; Bloom, E D; Bonino, R; Bregeon, J; Britto, R J; Bruel, P; Buehler, R; Caliandro, G A; Cameron, R A; Caragiulo, M; Caraveo, P A; Cavazzuti, E; Cecchi, C; Charles, E; Chekhtman, A; Chiang, J; Chiaro, G; Ciprini, S; Cohen-Tanugi, J; Cominsky, L R; Costanza, F; Cutini, S; D'Ammando, F; de Angelis, A; de Palma, F; Desiante, R; Digel, S W; Di Mauro, M; Di Venere, L; Domínguez, A; Drell, P S; Favuzzi, C; Fegan, S J; Ferrara, E C; Franckowiak, A; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Giglietto, N; Giommi, P; Giordano, F; Giroletti, M; Godfrey, G; Green, D; Grenier, I A; Guiriec, S; Hays, E; Horan, D; Iafrate, G; Jogler, T; Jóhannesson, G; Kuss, M; La Mura, G; Larsson, S; Latronico, L; Li, J; Li, L; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Magill, J; Maldera, S; Manfreda, A; Mayer, M; Mazziotta, M N; Michelson, P F; Mitthumsiri, W; Mizuno, T; Moiseev, A A; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Negro, M; Nuss, E; Ohsugi, T; Okada, C; Omodei, N; Orlando, E; Ormes, J F; Paneque, D; Perkins, J S; Pesce-Rollins, M; Petrosian, V; Piron, F; Pivato, G; Porter, T A; Rainò, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Reposeur, T; Romani, R W; Sánchez-Conde, M; Schmid, J; Schulz, A; Sgrò, C; Simone, D; Siskind, E J; Spada, F; Spandre, G; Spinelli, P; Suson, D J; Takahashi, H; Thayer, J B; Tibaldo, L; Torres, D F; Troja, E; Vianello, G; Yassine, M; Zimmer, S

2016-04-15

The Fermi Large Area Telescope (LAT) Collaboration has recently released a catalog of 360 sources detected above 50 GeV (2FHL). This catalog was obtained using 80 months of data re-processed with Pass 8, the newest event-level analysis, which significantly improves the acceptance and angular resolution of the instrument. Most of the 2FHL sources at high Galactic latitude are blazars. Using detailed Monte Carlo simulations, we measure, for the first time, the source count distribution, dN/dS, of extragalactic γ-ray sources at E>50  GeV and find that it is compatible with a Euclidean distribution down to the lowest measured source flux in the 2FHL (∼8×10^{-12}  ph cm^{-2} s^{-1}). We employ a one-point photon fluctuation analysis to constrain the behavior of dN/dS below the source detection threshold. Overall, the source count distribution is constrained over three decades in flux and found compatible with a broken power law with a break flux, S_{b}, in the range [8×10^{-12},1.5×10^{-11}]  ph cm^{-2} s^{-1} and power-law indices below and above the break of α_{2}∈[1.60,1.75] and α_{1}=2.49±0.12, respectively. Integration of dN/dS shows that point sources account for at least 86_{-14}^{+16}% of the total extragalactic γ-ray background. The simple form of the derived source count distribution is consistent with a single population (i.e., blazars) dominating the source counts to the minimum flux explored by this analysis. We estimate the density of sources detectable in blind surveys that will be performed in the coming years by the Cherenkov Telescope Array.

Resolving the Extragalactic γ -Ray Background above 50 GeV with the Fermi Large Area Telescope

DOE PAGES

Ackermann, M.; Ajello, M.; Albert, A.; ...

2016-04-14

The Fermi Large Area Telescope (LAT) Collaboration has recently released a catalog of 360 sources detected above 50 GeV (2FHL). This catalog was obtained using 80 months of data re-processed with Pass 8, the newest event-level analysis, which significantly improves the acceptance and angular resolution of the instrument. Most of the 2FHL sources at high Galactic latitude are blazars. In this paper, using detailed Monte Carlo simulations, we measure, for the first time, the source count distribution, dN/dS, of extragalactic γ-ray sources at E > 50 GeV and find that it is compatible with a Euclidean distribution down to the lowest measured source flux in the 2FHL (~8 x 10 -12 ph cm -2s -1). We employ a one-point photon fluctuation analysis to constrain the behavior of dN/dS below the source detection threshold. Overall, the source count distribution is constrained over three decades in flux and found compatible with a broken power law with a break flux, S b, in the range [8 x 10 -12, 1.5 x 10 -11] ph cm -2s -1 and power-law indices below and above the break of α 2 ϵ [1.60, 1.75] and α 1 = 2.49 ± 0.12, respectively. Integration of dN/dS shows that point sources account for at least 86more » $$+16\\atop{-14}$$ % of the total extragalactic γ-ray background. The simple form of the derived source count distribution is consistent with a single population (i.e., blazars) dominating the source counts to the minimum flux explored by this analysis. Finally, we estimate the density of sources detectable in blind surveys that will be performed in the coming years by the Cherenkov Telescope Array.« less

Application of adaptive antenna techniques to future commercial satellite communication

NASA Technical Reports Server (NTRS)

Ersoy, L.; Lee, E. A.; Matthews, E. W.

1987-01-01

The purpose of this contract was to identify the application of adaptive antenna technique in future operational commercial satellite communication systems and to quantify potential benefits. The contract consisted of two major subtasks. Task 1, Assessment of Future Commercial Satellite System Requirements, was generally referred to as the Adaptive section. Task 2 dealt with Pointing Error Compensation Study for a Multiple Scanning/Fixed Spot Beam Reflector Antenna System and was referred to as the reconfigurable system. Each of these tasks was further sub-divided into smaller subtasks. It should also be noted that the reconfigurable system is usually defined as an open-loop system while the adaptive system is a closed-loop system. The differences between the open- and closed-loop systems were defined. Both the adaptive and reconfigurable systems were explained and the potential applications of such systems were presented in the context of commercial communication satellite systems.

Application of adaptive antenna techniques to future commercial satellite communications. Executive summary

NASA Technical Reports Server (NTRS)

Ersoy, L.; Lee, E. A.; Matthews, E. W.

1987-01-01

The purpose of this contract was to identify the application of adaptive antenna technique in future operational commercial satellite communication systems and to quantify potential benefits. The contract consisted of two major subtasks. Task 1, Assessment of Future Commercial Satellite System Requirements, was generally referred to as the Adaptive section. Task 2 dealt with Pointing Error Compensation Study for a Multiple Scanning/Fixed Spot Beam Reflector Antenna System and was referred to as the reconfigurable system. Each of these tasks was further subdivided into smaller subtasks. It should also be noted that the reconfigurable system is usually defined as an open-loop system while the adaptive system is a closed-loop system. The differences between the open- and closed-loop systems were defined. Both the adaptive and reconfigurable systems were explained and the potential applications of such systems were presented in the context of commercial communication satellite systems.

Improved Safety Margin Characterization of Risk from Loss of Offsite Power

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, Paul

Original intent: The original intent of this task was “support of the Risk-Informed Safety Margin Characteristic (RISMC) methodology in order” “to address … efficiency of computation so that more accurate and cost-effective techniques can be used to address safety margin characterizations” (S. M. Hess et al., “Risk-Informed Safety Margin Characterization,” Procs. ICONE17, Brussels, July 2009, CD format). It was intended that “in Task 1 itself this improvement will be directed toward upon the very important issue of Loss of Offsite Power (LOOP) events,” more specifically toward the challenge of efficient computation of the multidimensional nonrecovery integral that has been discussedmore » by many previous contributors to the theory of nuclear safety. It was further envisioned that “three different computational approaches will be explored,” corresponding to the three subtasks listed below; deliverables were tied to the individual subtasks.« less

Assessing of imagined and real expanded Timed Up and Go tests in patients with chronic stroke: A case-control study.

PubMed

Geiger, Maxime; Bonnyaud, Céline; Bussel, Bernard; Roche, Nicolas

2018-05-08

To assess temporal congruence (the difference in performance-time and time to imagine) between the sub-tasks of the Expanded Timed Up and Go (ETUG) and imagined ETUG (iETUG) tests in patients with hemiparesis following unilateral hemispheric stroke, and to compare the results with those for with healthy subjects. Case-controlled study. Subject/patients: Twenty patients with chronic stroke and 20 healthy subjects. TUG, ETUG and iETUG test performance times were recorded for all participants. Temporal congruence was calculated with the following formula: (ETUG-iETUG)/[(ETUG+iETUG)/2]*100. Patients' performances were slower than those of healthy subjects for all 5 sub-tasks of the TUG, ETUG and iETUG tests. However, there was no significant difference in temporal congruence between healthy subjects and patients. Intragroup analysis showed significant differences between the executed and the imagined conditions for both groups for the "walking", "turn around" and "sitting" phases (healthy subjects p = 0.01, p = 0.03, p = 0.03, and patients p = 0.01, p = 0.003, p = 0.003, respectively). Temporal congruence was similar for healthy subjects and patients for all sub-tasks of the ETUG test. Moreover, temporal congruence was reduced for the same sub-tasks of the ETUG test in patients and healthy subjects. This suggests that the motor imagery involved the same cerebral structures in both groups, probably including the cerebellum, since it was intact in all patients.

DETERMINATION OF A BOUND MUSK XYLENE ...

EPA Pesticide Factsheets

Musk xylene (MX) is widely used as a fragrance ingredient in commercial toiletries. Identification and quantification of a bound 4-amino-MX (AMX) metabolite was carried out by gas chromatography-mass spectrometry (GC/MS), with selected ion monitoring (SIM). Detection of AMX occurred after the cysteine adducts in carp hemoglobin, derived from the nitroso metabolite, were released by alkaline hydrolysis. The released AMX metabolite was extracted into n-hexane. The extract was preconcentrated by evaporation, and analyzed by GC-SIM-MS. The concentration of AMX metabolite was found to range from 6.0 to 30.6 ng/g in the carp Hb, collected from the Las Vegas Wash and Lake Mead, Nevada areas. The presence of an AMX metabolite in the carp Hb was confirmed when similar mass spectral features and the same retention time of the AMX metabolite were obtained for both standard AMX and carp Hb extract solutions. In the non-hydrolyzed and reagent blank extracts, the AMX metabolite was not detected. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each project's objective is stated below.Subtask 1: To integrate state-of-the-art technologies (polar organic chemical integrative samplers,

FBI fingerprint identification automation study. AIDS 3 evaluation report. Volume 2: Technical feasibility

NASA Technical Reports Server (NTRS)

Mulhall, B. D. L.

1980-01-01

The results of this effort are presented in a manner for use by both the AIDS 3 Operational and Economic Feasibility subtasks as well as the Development of Alternative subtask. The approach taken was to identify the major functions that appear in AIDS 3 and then to determine which technologies would be needed for support. The technologies were then examined from the point of view of reliability, throughput, security, availability, cost and possible future trends. Whenever possible graphs are given to indicate projected costs of rapidly changing technologies.

An Investigation into the Nature of Non-Voiding Contractions Resulting from Detrusor Hyperreflexia in Neurogenic Bladders Following Spinal Cord Injury

DTIC Science & Technology

2014-10-01

SCI) is often occasioned by numerous, rhythmic high pressure non-voiding contractions (NVC) during normal bladder filling. These NVC are...addition to the 16.5 month experiment period) 2c. Final data analysis (data analysis will be ongoing throughout, this will represent the finalization...accomplished. We accomplished Sub-Tasks 2a and 2b. As of 9/2/14, we have completed much of the data analysis (Sub-Task 2c; see below for results). Analysis

49 CFR 173.52 - Classification codes and compatibility groups of explosives.

Code of Federal Regulations, 2011 CFR

2011-10-01

... one containing white phosphorus, phosphide or flammable liquid or gel or hypergolic liquid) G 1.1G1.2G 1.3G 1.4G Article containing both an explosive substance and white phosphorus H 1.2H1.3H Article...

49 CFR 173.52 - Classification codes and compatibility groups of explosives.

Code of Federal Regulations, 2010 CFR

2010-10-01

... one containing white phosphorus, phosphide or flammable liquid or gel or hypergolic liquid) G 1.1G1.2G 1.3G 1.4G Article containing both an explosive substance and white phosphorus H 1.2H1.3H Article...

Capturing with EEG the neural entrainment and coupling underlying sensorimotor synchronization to the beat.

PubMed

Nozaradan, Sylvie; Zerouali, Younes; Peretz, Isabelle; Mouraux, André

2015-03-01

Synchronizing movements with rhythmic inputs requires tight coupling of sensory and motor neural processes. Here, using a novel approach based on the recording of steady-state-evoked potentials (SS-EPs), we examine how distant brain areas supporting these processes coordinate their dynamics. The electroencephalogram was recorded while subjects listened to a 2.4-Hz auditory beat and tapped their hand on every second beat. When subjects tapped to the beat, the EEG was characterized by a 2.4-Hz SS-EP compatible with beat-related entrainment and a 1.2-Hz SS-EP compatible with movement-related entrainment, based on the results of source analysis. Most importantly, when compared with passive listening of the beat, we found evidence suggesting an interaction between sensory- and motor-related activities when subjects tapped to the beat, in the form of (1) additional SS-EP appearing at 3.6 Hz, compatible with a nonlinear product of sensorimotor integration; (2) phase coupling of beat- and movement-related activities; and (3) selective enhancement of beat-related activities over the hemisphere contralateral to the tapping, suggesting a top-down effect of movement-related activities on auditory beat processing. Taken together, our results are compatible with the view that rhythmic sensorimotor synchronization is supported by a dynamic coupling of sensory and motor related activities. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Policy Capturing with Local Models: The Application of the AID technique in Modeling Judgment

DTIC Science & Technology

1972-12-01

or coding phases have upon the derived policy modelo . Particularly important aspects of these subtasks include: 1) Initial identification and coding of...in o c building pJha~sed a.ird the 1 50 a ~pli- atuls f the cr osi - vuljdatiof po[pulationl. Th.is iiicreasv iii aitr ilvatabl to Lxo ba sic fa ctu r

Importance of the High-Expression of Proline Transporter PutP to the Adaptation of Escherichia coli to High Salinity.

PubMed

Sasaki, Hideaki; Sato, Daichi; Oshima, Akinobu

2017-01-01

　The effect of the amount of the proline transporter PutP expression on the mechanism of adaptation of E. coli cells to high salinity was analyzed. The PutP gene derived from the E. coli expression plasmid was introduced into the E. coli cell, and a high PutP expression strain was developed. At 1.2 M NaCl culture condition, the growth of normal E. coli cells was inhibited, whereas high ProP expression cells showed growth under 2.5 M NaCl conditions. The uptake of proline by E. coli as a compatible solute and substrate for metabolization was in good accordance with those seen in cell growth. These data suggested that the amount of the proline transporter PutP expression played an important role in the adaptation of E. coli cells to high saline conditions.

Manufacturing Technology (MATES) II. Task Order 0006: Air Force Technology and Industrial Base Research Sub-Task 07: Future Advances in Electronic Materials and Processes-Flexible Hybrid Electronics

DTIC Science & Technology

2016-02-29

A-E) Ring Resonators (RR); (F) Optically Pumped Laser in RR; G) Coupled RR; H) Ultra-High Q-factor [942...tendency of particulates suspended in coffee to move towards the edges of a coffee spill, causing a ring -like stain after the solvent has evaporated...variety of functions, including to make the surface non-sticky (anti-blocking), to allow the surfaces to slide over one another ( slip aid), to cause the

Multi-task feature learning by using trace norm regularization

NASA Astrophysics Data System (ADS)

Jiangmei, Zhang; Binfeng, Yu; Haibo, Ji; Wang, Kunpeng

2017-11-01

Multi-task learning can extract the correlation of multiple related machine learning problems to improve performance. This paper considers applying the multi-task learning method to learn a single task. We propose a new learning approach, which employs the mixture of expert model to divide a learning task into several related sub-tasks, and then uses the trace norm regularization to extract common feature representation of these sub-tasks. A nonlinear extension of this approach by using kernel is also provided. Experiments conducted on both simulated and real data sets demonstrate the advantage of the proposed approach.

TOOL FOR MONITORING HYDROPHILIC CONTAMINANTS ...

EPA Pesticide Factsheets

Global emissions of persistent bioconcentratable organic chemicals have resulted in a wide range of adverse ecological effects. Consequently, industry was led to develop less persistent, more water soluble, polar or hydrophilic organic compounds (HpOCs), which generally have low bioconcentration factors. However, evidence is growing that the large fluxes of these seemingly more environmentally friendly compounds (e.g., pesticides, prescription and non-prescription drugs, personal care and common consumer products, industrial and domestic-use chemicals and their degradation products) into aquatic systems on a world-wide basis may be responsible for incidents of acute toxicity and sub-lethal chronic abnormalities. These adverse effects include altered behavior, neurotoxicity, and severely impaired reproduction. Furthermore, the presence of these HpOCs likely plays a major role in the endocrine disrupting effects of complex mixtures of chemicals present in aquatic environments. In regard to physiological effects, pharmaceuticals are of particular concern because they are designed to elicit diverse pharmacological responses at very low doses. Unfortunately, the effects of this class of HpOCs on non-target, aquatic organisms are largely unknown. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are

C3I system modification and EMC (electromagnetic compatibility) methodology, volume 1

NASA Astrophysics Data System (ADS)

Wilson, J. L.; Jolly, M. B.

1984-01-01

A methodology (i.e., consistent set of procedures) for assessing the electromagnetic compatibility (EMC) of RF subsystem modifications on C3I aircraft was generated during this study (Volume 1). An IEMCAP (Intrasystem Electromagnetic Compatibility Analysis Program) database for the E-3A (AWACS) C3I aircraft RF subsystem was extracted to support the design of the EMC assessment methodology (Volume 2). Mock modifications were performed on the E-3A database to assess, using a preliminary form of the methodology, the resulting EMC impact. Application of the preliminary assessment methodology to modifications in the E-3A database served to fine tune the form of a final assessment methodology. The resulting final assessment methodology is documented in this report in conjunction with the overall study goals, procedures, and database. It is recommended that a similar EMC assessment methodology be developed for the power subsystem within C3I aircraft. It is further recommended that future EMC assessment methodologies be developed around expert systems (i.e., computer intelligent agents) to control both the excruciating detail and user requirement for transparency.

In-Situ NDE Characterization of Kevlar and Carbon Composite Micromechanics for Improved COPV Health Monitoring

NASA Technical Reports Server (NTRS)

Waller, Jess M.; Saulsberry, Regor L.

2009-01-01

This project is a subtask of a multi-center project to advance the state-of-the-art by developing NDE techniques that are capable of evaluating stress rupture (SR) degradation in Kevlar/epoxy (K/Ep) composite overwrapped pressure vessels (COPVs), and damage progression in carbon/epoxy (C/Ep) COPVs. In this subtask, acoustic emission (AE) data acquired during intermittent load hold tensile testing of K/Ep and C/Ep composite tow materials-of-construction used in COPV fabrication were analyzed to monitor progressive damage during the approach to tensile failure. Insight into the progressive damage of composite tow was gained by monitoring AE event rate, energy, source location, and frequency. Source location based on arrival time data was used to discern between significant AE attributable to microstructural damage and spurious AE attributable to background and grip noise. One of the significant findings was the observation of increasing violation of the Kaiser effect (Felicity ratio < 1.0) with damage accumulation.

Strategic avionics technology definition studies. Subtask 3-1A: Electrical Actuation (ELA) systems

NASA Technical Reports Server (NTRS)

Pond, Charles L.; Mcdermott, William A.; Lum, Ben T. F.

1993-01-01

Electrical actuator (ELA) power efficiency and requirements are examined for space system application. Requirements for Space Shuttle effector systems are presented, along with preliminary ELA trades and selection to form a preliminary ELA system baseline. Power and energy requirements for this baseline ELA system are applicable to the Space Shuttle and similar space vehicles.

LEVELS OF SYNTHETIC MUSKS COMPOUNDS IN ...

EPA Pesticide Factsheets

Synthetic musk compounds are consumer chemicals manufactured as fragrance materials and consumed in very large quantities worldwide. Due to their high use and release, they have become ubiquitous in the environment. We analyzed water samples from the confluence of three municipal sewage treatment effluent streams, surface water, and whole carp ( Cyprinus carpio) for synthetic musks for a period of 12 months. The lipid content of each fish was determined and compared with the concentration of musks in the whole fish tissue. Innovative methods were used for water sampling and musk extraction. The data presented here provide insight as to the relationship between concentrations of synthetic musks in the municipal effluent and associated biota. This study confirmed the presence of polycylic and nitro musk compounds in sewage effluuent, Lake Mead water, and carp. The concentrations were found to be considerably lower than previous studies conducted in oilier countries. This study also established the statistical variation in the concentrations of Galaxolide (a polycyclic musk) and musk xylene (a nitro musk) in carp. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth coverage of each project. Briefly, each pro

H.E.S.S. observations of the binary system PSR B1259-63/LS 2883 around the 2010/2011 periastron passage

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abramowski, A.; Acero, F.; Aharonian, F.; Akhperjanian, A. G.; Anton, G.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Biteau, J.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Chaves, R. C. G.; Cheesebrough, A.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Egberts, K.; Eger, P.; Espigat, P.; Fallon, L.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Gast, H.; Giebels, B.; Glicenstein, J. F.; Glück, B.; Göring, D.; Grondin, M.-H.; Grudzińska, M.; Häer, S.; Hague, J. D.; Hahn, J.; Hampf, D.; Harris, J.; Heinz, S.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Kossakowski, R.; Krayzel, F.; Krüger, P. P.; Lan, H.; Lamanna, G.; Lefaucheur, J.; Lemoine-Goumard, M.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Masbou, J.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Menzler, U.; Moderski, R.; Mohamed, M.; Moulin, E.; Naumann, C. L.; Naumann-Godo, M.; de Naurois, M.; Nedbal, D.; Nguyen, N.; Niemiec, J.; Nolan, S. J.; Oakes, L.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Ripken, J.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sheidaei, F.; Skilton, J. L.; Sol, H.; Spengler, G.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tavernet, J.-P.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorobiov, S.; Vorster, M.; Wagner, S. J.; Ward, M.; White, R.; Wierzcholska, A.; Willmann, P.; Wouters, D.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

2013-03-01

Aims: We present very high energy (VHE; E > 100 GeV) data from the γ-ray binary system PSR B1259-63/LS 2883 taken around its periastron passage on 15th of December 2010 with the High Energy Stereoscopic System (H.E.S.S.) of Cherenkov Telescopes. We aim to search for a possible TeV counterpart of the GeV flare detected by the Fermi LAT. In addition, we aim to study the current periastron passage in the context of previous observations taken at similar orbital phases, testing the repetitive behaviour of the source. Methods: Observations at VHEs were conducted with H.E.S.S. from 9th to 16th of January 2011. The total dataset amounts to ~6 h of observing time. The data taken around the 2004 periastron passage were also re-analysed with the current analysis techniques in order to extend the energy spectrum above 3 TeV to fully compare observation results from 2004 and 2011. Results: The source is detected in the 2011 data at a significance level of 11.5σ revealing an averaged integral flux above 1 TeV of (1.01 ± 0.18stat ± 0.20sys) × 10-12 cm-2 s-1. The differential energy spectrum follows a power-law shape with a spectral index Γ = 2.92 ± 0.30stat ± 0.20sys and a flux normalisation at 1 TeV of N0 = (1.95 ± 0.32stat ± 0.39sys) × 10-12 TeV-1 cm-2 s-1. The measured light curve does not show any evidence for variability of the source on the daily scale. The re-analysis of the 2004 data yields results compatible with the published ones. The differential energy spectrum measured up to ~10 TeV is consistent with a power law with a spectral index Γ = 2.81 ± 0.10stat ± 0.20sys and a flux normalisation at 1 TeV of N0 = (1.29 ± 0.08stat ± 0.26sys) × 10-12 TeV-1 cm-2 s-1. Conclusions: The measured integral flux and the spectral shape of the 2011 data are compatible with the results obtained around previous periastron passages. The absence of variability in the H.E.S.S. data indicates that the GeV flare observed by Fermi LAT in the time period covered also by H.E.S.S. observations originates in a different physical scenario than the TeV emission. Moreover, the comparison of the new results to the results from the 2004 observations made at a similar orbital phase provides a stronger evidence of the repetitive behaviour of the source.

NFAT Signaling and the Tumorigenic Microenvironment of the Prostate

DTIC Science & Technology

2016-10-01

Subtask 2: Investigate if NFATc1 promotes the progression of hormone -naïve prostate cancer into castration-resistant prostate cancer 1-18 Drs...combating prostate cancer progression. In order to determine if NFATc1-induced prostate cancer would respond to hormone deprivation therapy, such as...doxycycline (Dox). These tumor cells were then injected to the rear flanks of the nude mice. Recipient mice treated with Dox showed growth of tumor as

Intra-Articular Lubricin Gene Therapy for Post-Traumatic Arthritis

DTIC Science & Technology

2016-09-01

Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Twenty- six rabbits underwent sham or ACLT surgery and were euthanized at 4...What was accomplished under these goals? 1) Major Activities Major Task 1: Twenty- six rabbits underwent sham or ACLT surgery and were treated at time 0...Task 1: Twenty six rabbits underwent surgery (sham or ACLT) and treatment (AAV-GFP or AAV-GFPLub) (Table), bringing the total number for Subtask 2 to

STOPP/START Medication Criteria Modified for US Nursing Home Setting

PubMed Central

Khodyakov, Dmitry; Ochoa, Aileen; Olivieri-Mui, Brianne L.; Bouwmeester, Carla; Zarowitz, Barbara J.; Patel, Meenakshi; Ching, Diana; Briesacher, Becky

2016-01-01

STRUCTURED ABSTRACT BACKGROUND/OBJECTIVES A barrier to assessing the quality of prescribing in nursing homes (NH) is the lack of explicit criteria for this setting. Our objective was to develop a set of prescribing indicators measurable with available data from electronic nursing home databases by adapting the European-based 2014 STOPP/START criteria of potentially inappropriate and underused medications for the US setting. DESIGN A two-stage expert panel process. In first stage, investigator team reviewed 114 criteria for compatibility and measurability. In second stage, we convened an online modified e-Delphi (OMD) panel to rate the validity of criteria and two webinars to identify criteria with highest relevance to US NHs. PARTICIPANTS Seventeen experts with recognized reputations in NH care participated in the e-Delphi panel and 12 in the webinar. MEASUREMENTS Compatibility and measurability were assessed by comparing criteria to US terminology/setting standards and data elements in NH databases. Validity was rated with a 9-point Likert-type scale (1=not valid at all, 9=highly valid). Mean, median, interpercentile ranges, and agreement were determined for each criterion score. Relevance was determined by ranking the mean panel ratings on criteria that reached agreement; half of the criteria with the highest mean values were reviewed and approved by the webinar participants. RESULTS Fifty-three STOPP/START criteria were deemed as compatible with US setting and measurable using data from electronic NH databases. E-Delphi panelists rated 48 criteria as valid for US NHs. Twenty-four criteria were deemed as most relevant, consisting of 22 measures of potentially inappropriate medications and 2 measures of underused medications. CONCLUSION This study created the first explicit criteria for assessing the quality of prescribing in US NHs. PMID:28008599

TARGET - TASK ANALYSIS REPORT GENERATION TOOL, VERSION 1.0

NASA Technical Reports Server (NTRS)

Ortiz, C. J.

1994-01-01

The Task Analysis Report Generation Tool, TARGET, is a graphical interface tool used to capture procedural knowledge and translate that knowledge into a hierarchical report. TARGET is based on VISTA, a knowledge acquisition tool developed by the Naval Systems Training Center. TARGET assists a programmer and/or task expert organize and understand the steps involved in accomplishing a task. The user can label individual steps in the task through a dialogue-box and get immediate graphical feedback for analysis. TARGET users can decompose tasks into basic action kernels or minimal steps to provide a clear picture of all basic actions needed to accomplish a job. This method allows the user to go back and critically examine the overall flow and makeup of the process. The user can switch between graphics (box flow diagrams) and text (task hierarchy) versions to more easily study the process being documented. As the practice of decomposition continues, tasks and their subtasks can be continually modified to more accurately reflect the user's procedures and rationale. This program is designed to help a programmer document an expert's task thus allowing the programmer to build an expert system which can help others perform the task. Flexibility is a key element of the system design and of the knowledge acquisition session. If the expert is not able to find time to work on the knowledge acquisition process with the program developer, the developer and subject matter expert may work in iterative sessions. TARGET is easy to use and is tailored to accommodate users ranging from the novice to the experienced expert systems builder. TARGET is written in C-language for IBM PC series and compatible computers running MS-DOS and Microsoft Windows version 3.0 or 3.1. No source code is supplied. The executable also requires 2Mb of RAM, a Microsoft compatible mouse, a VGA display and an 80286, 386 or 486 processor machine. The standard distribution medium for TARGET is one 5.25 inch 360K MS-DOS format diskette. TARGET was developed in 1991.

EMC (Electromagnetic Compatibility) Standards Handbook. Revision 4,

DTIC Science & Technology

1982-11-01

report was prepared by the lIT Research Institute as part of AF Project 649E under Contract F-19628-80-C-0042 with the Electronic Systems Division of...the Air Pbrce Systems Command in support of the DoD Electromagnetic Compatibility Analysis Center, Annapolis, Maryland. This report has been reviewed...3-1 "JVDE Organizations .. .0 . . . . . . . . . . . . . . . . . . . . . 3 1 VDE Testing Station

Controlling Mitochondrial Dynamics to Mitigate Noise-Induced Hearing Loss

DTIC Science & Technology

2016-10-01

exposure significantly reduced noise-induced auditory threshold shifts in our mouse model of NIHL. Additionally, protection against outer hair cell...and at 6 hours post-noise exposure. ‐ Perform analysis of outer auditory hair cells and synaptic ribbons from the different treatment groups...have made progress towards the completion of the outer hair cell counts (OHC) for this Subtask, particularly for study groups (1) mdivi-1/vehicle, and

Underground Test Area Subproject Phase I Data Analysis Task. Volume VIII - Risk Assessment Documentation Package

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Volume VIII of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the risk assessment documentation. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

Ontological Problem-Solving Framework for Assigning Sensor Systems and Algorithms to High-Level Missions

PubMed Central

Qualls, Joseph; Russomanno, David J.

2011-01-01

The lack of knowledge models to represent sensor systems, algorithms, and missions makes opportunistically discovering a synthesis of systems and algorithms that can satisfy high-level mission specifications impractical. A novel ontological problem-solving framework has been designed that leverages knowledge models describing sensors, algorithms, and high-level missions to facilitate automated inference of assigning systems to subtasks that may satisfy a given mission specification. To demonstrate the efficacy of the ontological problem-solving architecture, a family of persistence surveillance sensor systems and algorithms has been instantiated in a prototype environment to demonstrate the assignment of systems to subtasks of high-level missions. PMID:22164081

Underground Test Area Subproject Phase I Data Analysis Task. Volume VII - Tritium Transport Model Documentation Package

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Volume VII of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the tritium transport model documentation. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

Artificial Immune Algorithm for Subtask Industrial Robot Scheduling in Cloud Manufacturing

NASA Astrophysics Data System (ADS)

Suma, T.; Murugesan, R.

2018-04-01

The current generation of manufacturing industry requires an intelligent scheduling model to achieve an effective utilization of distributed manufacturing resources, which motivated us to work on an Artificial Immune Algorithm for subtask robot scheduling in cloud manufacturing. This scheduling model enables a collaborative work between the industrial robots in different manufacturing centers. This paper discussed two optimizing objectives which includes minimizing the cost and load balance of industrial robots through scheduling. To solve these scheduling problems, we used the algorithm based on Artificial Immune system. The parameters are simulated with MATLAB and the results compared with the existing algorithms. The result shows better performance than existing.

Basic and applied research program. Semiannual report, July-December 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Butler, B.L.

1979-12-01

The status of research projects in the Basic and Applied Research Program at SERI is presented for the semiannual period ending December 31, 1978. The five tasks in this program are grouped into Materials Research and Development, Materials Processing and Development, Photoconversion Research, Exploratory Research, and Energy Resource and Assessment and have been carried out by personnel in the Materials, Bio/Chemical Conversion, and Energy Resource and Assessment Branches. Subtask elements in the task areas include coatings and films, polymers, metallurgy and corrosion, optical materials, surfaces and interfaces in materials research and development; photochemistry, photoelectrochemistry, and photobiology in photoconversion; thin glassmore » mirror development, silver degradation of mirrors, hail resistance of thin glass, thin glass manufacturing, cellular glass development, and sorption by desiccants in materials processing and development; and thermoelectric energy conversion, desiccant cooling, photothermal degradation, and amorphous materials in exploratory research. For each task or subtask element, the overview, scope, goals, approach, apparatus and equipment, and supporting subcontracts are presented, as applicable, in addition to the status of the projects in each task or subtask. Listing of publications and reports authored by personnel associated with the Basic and Applied Research Program and prepared or published during 1978 are also included.« less

A subliminal inhibitory mechanism for the negative compatibility effect: a continuous versus threshold mechanism.

PubMed

Liu, Peng; Chen, Xuhai; Dai, Dongyang; Wang, Yongchun; Wang, Yonghui

2014-07-01

The current study investigated the mechanism underlying subliminal inhibition using the negative compatibility effect (NCE) paradigm. We hypothesized that a decrease in prime activation affects the subsequent inhibitory process, delaying onset of inhibition and reducing its strength. Two experiments tested this hypothesis using arrow stimuli as primes and targets. Two different irrelevant masks (i.e., a mask sharing no prime features) were presented in succession in each trial to not only ensure that primes were processed subliminally, but also avoid feature updating between primes and masks. Prime/target compatibility and prime background density were manipulated in Experiment 1. Results showed that under subliminal inhibitory condition, the NCE disappears when the density increases (i.e., pixel density in the prime's background of 25 %) in Experiment 1. However, when we fixed the prime's background at the density of 25 % and manipulated prime/target compatibility as well as inter-stimuli-interval (ISI) between mask and target in Experiment 2, behavioral results showed marginally significant NCEs in the 150-ms ISI condition. Electrophysiological evidence showed the lateralized readiness potential for compatible trials was significantly more positive than that for incompatible trials during the two consecutive time windows (i.e., 400-450 and 450-500 ms) in the 150-ms ISI condition. In addition, the NCE size was significant smaller in Experiment 2 than in Experiment 1. All of the results support predictions of the continuous subliminal inhibitory mechanism hypothesis which posits that decreases in prime activation strength lead to delay in inhibitory onset and decline in inhibitory strength.

A rate-compatible family of protograph-based LDPC codes built by expurgation and lengthening

NASA Technical Reports Server (NTRS)

Dolinar, Sam

2005-01-01

We construct a protograph-based rate-compatible family of low-density parity-check codes that cover a very wide range of rates from 1/2 to 16/17, perform within about 0.5 dB of their capacity limits for all rates, and can be decoded conveniently and efficiently with a common hardware implementation.

Local Area Network (LAN) Compatibility Issues

DTIC Science & Technology

1991-09-01

September, 1991 Thesis Advisor: Dr. Norman Schneidewind Approved for public release; distribution is unlimited 92 303s246 Unclassified SECURITY ...CLASSIFICATION OF THIS PAGE REPORT DOCUMENTATION PAGE Ia. REPORT SECURITY CLASSIFICATION 1 b. RESTRICTIVE MARKINGS unclassified 2a. SECURITY CLASSIFICATION...Work UiNt ACCeLUOn Number 11. TITLE (Include Security Classification) LOCAL AREA NETWORK (LAN) COMPATIBILITY ISSUES 12. PERSONAL AUTHOR(S) Rita V

Experimental search for the "LSND anomaly" with the ICARUS detector in the CNGS neutrino beam

NASA Astrophysics Data System (ADS)

Antonello, M.; Baibussinov, B.; Benetti, P.; Calligarich, E.; Canci, N.; Centro, S.; Cesana, A.; Cieślik, K.; Cline, D. B.; Cocco, A. G.; Dabrowska, A.; Dequal, D.; Dermenev, A.; Dolfini, R.; Farnese, C.; Fava, A.; Ferrari, A.; Fiorillo, G.; Gibin, D.; Gninenko, S.; Guglielmi, A.; Haranczyk, M.; Holeczek, J.; Ivashkin, A.; Kirsanov, M.; Kisiel, J.; Kochanek, I.; Lagoda, J.; Mania, S.; Menegolli, A.; Meng, G.; Montanari, C.; Otwinowski, S.; Piazzoli, A.; Picchi, P.; Pietropaolo, F.; Plonski, P.; Rappoldi, A.; Raselli, G. L.; Rossella, M.; Rubbia, C.; Sala, P. R.; Scantamburlo, E.; Scaramelli, A.; Segreto, E.; Sergiampietri, F.; Stefan, D.; Stepaniak, J.; Sulej, R.; Szarska, M.; Terrani, M.; Varanini, F.; Ventura, S.; Vignoli, C.; Wang, H. G.; Yang, X.; Zalewska, A.; Zaremba, K.

2013-03-01

We report an early result from the ICARUS experiment on the search for a ν μ → ν e signal due to the LSND anomaly. The search was performed with the ICARUS T600 detector located at the Gran Sasso Laboratory, receiving CNGS neutrinos from CERN at an average energy of about 20 GeV, after a flight path of ˜730 km. The LSND anomaly would manifest as an excess of ν e events, characterized by a fast energy oscillation averaging approximately to sin2(1.27Δ m2_{new}L/E_{ν})≈ 1/2 with probability P_{ν_{μ}→ νe} = 1/2 sin2(2θ_{new}). The present analysis is based on 1091 neutrino events, which are about 50 % of the ICARUS data collected in 2010-2011. Two clear ν e events have been found, compared with the expectation of 3.7±0.6 events from conventional sources. Within the range of our observations, this result is compatible with the absence of a LSND anomaly. At 90 % and 99 % confidence levels the limits of 3.4 and 7.3 events corresponding to oscillation probabilities < P_{ν_{μ}→ νe}rangle le 5.4 × 10^{-3} and < P_{ν_{μ}→ νe}rangle le 1.1 × 10^{-2} are set respectively. The result strongly limits the window of open options for the LSND anomaly to a narrow region around (Δ m 2,sin2(2 θ))new=(0.5 eV2,0.005), where there is an overall agreement (90 % CL) between the present ICARUS limit, the published limits of KARMEN and the published positive signals of LSND and MiniBooNE Collaborations.

Instrumentation: Nondestructive Examination for Verification of Canister and Cladding Integrity. FY2014 Status Update

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyer, Ryan M.; Suter, Jonathan D.; Jones, Anthony M.

2014-09-12

This report documents FY14 efforts for two instrumentation subtasks under storage and transportation. These instrumentation tasks relate to developing effective nondestructive evaluation (NDE) methods and techniques to (1) verify the integrity of metal canisters for the storage of used nuclear fuel (UNF) and to (2) verify the integrity of dry storage cask internals.

Biomarkers and Brain Mechanisms of Gulf War Illness

DTIC Science & Technology

2017-09-01

serve as biomarkers of the disorder. 15. SUBJECT TERMS Gulf War illness, neuroinflammation, oxidative stress , mitochondrial dysfunction, magnetic...Oxidative Stress , Mitochondrial Dysfunction; Magnetic Resonance Imaging, Positron Emission Tomography Page | 5 Subtask 2: Develop complementary or...30 Major Task 3: To conduct 1H and 31P MRS studies for assessment of oxidative stress and mitochondrial dysfunction in vivo. Assess cerebral blood

Information Presentation

NASA Technical Reports Server (NTRS)

Holden, K.L.; Boyer, J.L.; Sandor, A.; Thompson, S.G.; McCann, R.S.; Begault, D.R.; Adelstein, B.D.; Beutter, B.R.; Stone, L.S.

2009-01-01

The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. The major areas of work, or subtasks, within this DRP are: 1) Displays, 2) Controls, 3) Electronic Procedures and Fault Management, and 4) Human Performance Modeling. This DRP is a collaborative effort between researchers at Johnson Space Center and Ames Research Center.

Open Scenario Study: IDA Open Scenario Repository User’s Manual

DTIC Science & Technology

2010-01-01

Thomason, Study Co-Lead Zachary S. Rabold, Sub-Task Lead Ylli Bajraktari Rachel D. Dubin Mary Catherine Flythe Open Scenario Study: IDA Open Scenario... Bajraktari Rachel D. Dubin Mary Catherine Flythe Open Scenario Study: IDA Open Scenario Repository User’s Manual iii Preface This document reports the...vii Appendices A. Identifying Scenario Components...........................................................A-1 B . Acronyms

High-Throughput Screening for a Moderately Halophilic Phenol-Degrading Strain and Its Salt Tolerance Response

PubMed Central

Lu, Zhi-Yan; Guo, Xiao-Jue; Li, Hui; Huang, Zhong-Zi; Lin, Kuang-Fei; Liu, Yong-Di

2015-01-01

A high-throughput screening system for moderately halophilic phenol-degrading bacteria from various habitats was developed to replace the conventional strain screening owing to its high efficiency. Bacterial enrichments were cultivated in 48 deep well microplates instead of shake flasks or tubes. Measurement of phenol concentrations was performed in 96-well microplates instead of using the conventional spectrophotometric method or high-performance liquid chromatography (HPLC). The high-throughput screening system was used to cultivate forty-three bacterial enrichments and gained a halophilic bacterial community E3 with the best phenol-degrading capability. Halomonas sp. strain 4-5 was isolated from the E3 community. Strain 4-5 was able to degrade more than 94% of the phenol (500 mg·L−1 starting concentration) over a range of 3%–10% NaCl. Additionally, the strain accumulated the compatible solute, ectoine, with increasing salt concentrations. PCR detection of the functional genes suggested that the largest subunit of multicomponent phenol hydroxylase (LmPH) and catechol 1,2-dioxygenase (C12O) were active in the phenol degradation process. PMID:26020478

Understanding Gulf War Illness: An Integrative Modeling Approach

DTIC Science & Technology

2017-10-01

group (Task 2; Subtask1). The latest iteration of this analysis focused on n=11 animals control and n=11 DFP exposed animals without corticosterone... Groups : 1 – Control Group (Male and Female Intact) 2 – GWI Model – Cort+DFP (Male and Female OVX) 3 – Control OVX (Female) 4 – GWI Model + Enbrel...The designed protocol counts with five basic experimental groups : Group 1 (Untreated Control no toxic exposure); Group 2 (Toxic exposed, no

Calcification of MC3T3-E1 cells on titanium and zirconium.

PubMed

Umezawa, Takayuki; Chen, Peng; Tsutsumi, Yusuke; Doi, Hisashi; Ashida, Maki; Suzuki, Shoichi; Moriyama, Keiji; Hanawa, Takao

2015-01-01

To confirm similarity of hard tissue compatibility between titanium and zirconium, calcification of MC3T3-E1 cells on titanium and zirconium was evaluated in this study. Mirror-polished titanium (Ti) and zirconium (Zr) disks and zirconium-sputter deposited titanium (Zr/Ti) were employed in this study. The surface of specimens were characterized using scanning electron microscopy and X-ray diffraction. Then, the cellular proliferation, differentiation and calcification of MC3T3-E1 cells on specimens were investigated. The surface of Zr/Ti was much smoother and cleaner than those of Ti and Zr. The proliferation of the cell was the same among three specimens, while the differentiation and calcification on Zr/Ti were faster than those on Ti and Zr. Therefore, Ti and Zr showed the identical hard tissue compatibility according to the evaluation with MC3T3-E1 cells. Sputter deposition may improve cytocompatibility.

The impact of subliminal effect images in voluntary vs. stimulus-driven actions.

PubMed

Le Bars, Solène; Hsu, Yi-Fang; Waszak, Florian

2016-11-01

According to the ideomotor theory, actions are represented in terms of their sensory effects. In the current study we tested whether subliminal effect images influence action control (1) at early and/or late preparatory stages of (2) voluntary actions or stimulus-driven actions (3) with or without Stimulus-Response (S-R) compatibility. In Experiment 1, participants were presented at random with 50% of S-R compatible stimulus-driven action trials and 50% of voluntary action trials. The actions' effects (i.e. up- or down-pointing arrows) were presented subliminally before each action (i.e. a keypress). In voluntary actions, participants selected more often the action congruent with the prime when it was presented at long intervals before the action. Moreover they responded faster in prime-congruent than in prime-incongruent trials when primes were presented at short intervals before the action. In Experiment 2, participants were only presented with stimulus-driven action trials, with or without S-R compatibility. In stimulus-driven action trials with S-R compatibility (e.g., left-pointing arrow signaling a left keypress), subliminal action-effects did not generate any significant effect on RTs or error rates. On the other hand, in stimulus-driven action trials without S-R compatibility (e.g., letter "H" signaling a left keypress), participants were significantly faster in prime-congruent trials when primes were presented at the shortest time interval before the action. These results suggest that subliminal effect images facilitate voluntary action preparation on an early and a late level. Stimulus-driven action preparation is influenced on a late level only, and only if there is no compatibility between the stimulus and the motor response, that is when the response is not automatically triggered by the common properties existing between the stimulus and the required action. Copyright © 2016 Elsevier B.V. All rights reserved.

Discovery of a New Cellular Motion and Its Relevance to Breast Cancer and Involution

DTIC Science & Technology

2014-02-01

motion (CAMo), live cell imaging , confocal microscopy Overall Project Summary: During this first year of funding we have concentrated our work to...cell types in 3D cultures and in vivo. Subtask 1.1a: Real time live cell imaging using confocal microscopy will be used to image cellular movement...exciting as they are important steps in understanding behavior of normal myoepithelial cells using live cell imaging in physiologically

Development of an Integrated Team Training Design and Assessment Architecture to Support Adaptability in Healthcare Teams

DTIC Science & Technology

2017-10-01

to patient safety by addressing key methodological and conceptual gaps in healthcare simulation-based team training. The investigators are developing...primary outcome of Aim 1a is a conceptually and methodologically sound training design architecture that supports the development and integration of team...should be delivered. This subtask was delayed by approximately 1 month and is now completed. Completed Evaluation of existing experimental dataset to

Exploring Modality Compatibility in the Response-Effect Compatibility Paradigm.

PubMed

Földes, Noémi; Philipp, Andrea M; Badets, Arnaud; Koch, Iring

2017-01-01

According to ideomotor theory , action planning is based on anticipatory perceptual representations of action-effects. This aspect of action control has been investigated in studies using the response-effect compatibility (REC) paradigm, in which responses have been shown to be facilitated if ensuing perceptual effects share codes with the response based on dimensional overlap (i.e., REC). Additionally, according to the notion of ideomotor compatibility, certain response-effect (R-E) mappings will be stronger than others because some response features resemble the anticipated sensory response effects more strongly than others (e.g., since vocal responses usually produce auditory effects, an auditory stimulus should be anticipated in a stronger manner following vocal responses rather than following manual responses). Yet, systematic research on this matter is lacking. In the present study, two REC experiments aimed to explore the influence of R-E modality mappings. In Experiment 1, vocal number word responses produced visual effects on the screen (digits vs. number words; i.e., visual-symbolic vs. visual-verbal effect codes). The REC effect was only marginally larger for visual-verbal than for visual-symbolic effects. Using verbal effect codes in Experiment 2, we found that the REC effect was larger with auditory-verbal R-E mapping than with visual-verbal R-E mapping. Overall, the findings support the hypothesis of a role of R-E modality mappings in REC effects, suggesting both further evidence for ideomotor accounts as well as code-specific and modality-specific contributions to effect anticipation.

Exploring the representational basis of response-effect compatibility: Evidence from bilingual verbal response-effect mappings.

PubMed

Földes, Noémi; Philipp, Andrea M; Badets, Arnaud; Koch, Iring

2018-05-01

The ideomotor principle states that actions are represented by their anticipated sensory effects. This notion is often tested using the response-effect compatibility (REC) paradigm, where participants' responses are followed either by a compatible or incompatible response effect (e.g., an effect on the right side after a right-hand response is considered R-E compatible due to the spatial overlap, whereas an effect on the left side after the right-hand response is considered incompatible). Shorter reaction times are typically observed in the compatible condition compared to the incompatible condition (i.e., REC effect), suggesting that effect anticipation plays a role in action control. Previous evidence from verbal REC suggested that effect anticipation can be due to conceptual R-E overlap, but there was also phonological overlap (i.e., anticipated reading of a word preceded by the vocal response of saying that very word). To examine the representational basis of REC, in three experiments, we introduced a bilingual R-E mapping to exclude phonological R-E overlap (i.e., in the R-E compatible condition, the translation equivalent of the response word is presented as an effect word in a different language). Our findings show that the REC effect is obtained when presenting the effect word in the same language as the response (i.e., monolingual condition), but the compatibility effect was not found when the semantically same word is presented in a different language, suggesting no conceptually generalized REC in a bilingual setting. (232 words). Copyright © 2018 Elsevier B.V. All rights reserved.

Enhancing creativity: Proper body posture meets proper emotion.

PubMed

Hao, Ning; Xue, Hua; Yuan, Huan; Wang, Qing; Runco, Mark A

2017-02-01

This study tested whether compatibility or incompatibility between body posture and emotion was beneficial for creativity. In Study 1, participants were asked to solve the Alternative Uses Task (AUT) problems when performing open or closed body posture in positive or negative emotional state respectively. The results showed that originality of AUT performance was higher in the compatible conditions (i.e., open-positive and closed-negative) than in the incompatible conditions (i.e., closed-positive and open-negative). In Study 2, the compatibility effect was replicated in both the AUT and the Realistic Presented Problem test (i.e., RPP). Moreover, it was revealed that participants exhibited the highest associative flexibility in the open-positive condition, and the highest persistence in the closed-negative condition. These findings indicate that compatibility between body posture and emotion is beneficial for creativity. This may be because when the implicit emotions elicited by body posture match explicit emotions, the effects of emotions on creativity are enhanced, therefore promoting creativity through the flexibility or the persistence pathway respectively. Copyright © 2016 Elsevier B.V. All rights reserved.

Left ventricular diastolic function in patients with treated haemochromatosis.

PubMed

Davidsen, Einar Skulstad; Omvik, Per; Hervig, Tor; Gerdts, Eva

2009-02-01

We recently demonstrated reduced exercise capacity in phlebotomy treated genetic haemochromatosis in spite of normal systolic function. The present objective was to investigate diastolic function at rest. Diastolic function was echocardiographically assessed in 132 phlebotomy treated genetic haemochromatosis patients and 50 controls. Patients had higher body mass index and heart rate, higher transmitral early (E) (11.2+/-2.6 versus 10.4+/-2.2 cm) and atrial (A) (5.7+/-1.6 versus 5.0+/-1.6) velocity time integrals, pulmonary venous systolic peak velocity (0.58+/-0.12 versus 0.54+/-0.13 m/s) and ratio of E to spectral tissue Doppler E' velocity (6.3+/-1.6 versus 5.6+/-1.4, all p <0.05). Independently of age, heart rate, systolic blood pressure and body weight, having haemochromatosis remained statistically significantly associated with higher E (beta=0.27) and A (beta =0.18) velocity time integrals, pulmonary venous systolic peak velocity (beta =0.21), and E/E'-ratio (beta=0.25) in separate multivariate analyses (all p <0.05). In the youngest age tertile, patients had longer isovolumic relaxation time and lower E' than controls. Our findings are compatible with mildly impaired diastolic function in treated haemochromatosis, with delayed relaxation in the younger tertile, and an elevated filling pressure and pseudonormalisation with increasing age.

Cooperation driven coherence: Brains working hard together.

PubMed

Bezerianos, Anastasios; Sun, Yu; Chen, Yu; Woong, Kian Fong; Taya, Fumihiko; Arico, Pietro; Borghini, Gianluca; Babiloni, Fabio; Thakor, Nitish

2015-01-01

The current study aims to look at the difference in coupling of EEG activity of participant pairs while they perform a cooperative, concurrent, independent yet different task at high and low difficulty levels. Participants performed the National Aeronautics and Space Administration (NASA) designed Multi-Attribute Task Battery (MATB-II) task which simulates a pilot and copilot operating an aircraft. Each participant in the pair was responsible for 2 out of 4 subtasks which were independent and different from one another while all tasks occurs concurrently in real time with difficulty levels being the frequency that adjustments are required for each subtask. We found that as the task become more difficult, there was more coupling between the pilot and copilot.

On the functional role of human parietal cortex in number processing: How gender mediates the impact of a 'virtual lesion' induced by rTMS.

PubMed

Knops, Andre; Nuerk, Hans-Christoph; Sparing, Roland; Foltys, Henrik; Willmes, Klaus

2006-01-01

Areas around the horizontal part of the intraparietal sulcus (hIPS) have repeatedly been reported to participate in processing numerical magnitude. Using transcranial magnetic stimulation (TMS), we investigated the functional role of the hIPS by examining two effects from the domain of numerical cognition: in magnitude comparison tasks response latencies are inversely related to the numerical distance between two numbers. This distance effect indexes access to the mental number representation. In magnitude comparison tasks responses are faster when decade and unit comparison would lead to the same decision (e.g. 42_57, 4 < 5 and 2 < 7) than when they would not (e.g. 47_62, 4 < 6 but 7 > 2). This compatibility effect reflects unit-decade integration processes. Differential susceptibility of (fe)male participants to TMS was examined. We applied repetitive TMS (rTMS; 1Hz for 10 min) over the left hIPS in 12 participants (6 female). No stimulation and vertex stimulation served as control conditions. The effect of rTMS was mediated by gender: in male participants, the distance effect decreased after TMS over hIPS. For female participants distance and compatibility effect both increased. This modulation of the compatibility effect was limited in duration to no more than 4 min. The hIPS seems to be functionally involved both in number magnitude processing and in integrating unit-decade magnitude information of two-digit numbers. Relative hemispheric specialization of the hIPS with respect to two-digit magnitude comparison is discussed.

MAT - MULTI-ATTRIBUTE TASK BATTERY FOR HUMAN OPERATOR WORKLOAD AND STRATEGIC BEHAVIOR RESEARCH

NASA Technical Reports Server (NTRS)

Comstock, J. R.

1994-01-01

MAT, a Multi-Attribute Task battery, gives the researcher the capability of performing multi-task workload and performance experiments. The battery provides a benchmark set of tasks for use in a wide range of laboratory studies of operator performance and workload. MAT incorporates tasks analogous to activities that aircraft crew members perform in flight, while providing a high degree of experiment control, performance data on each subtask, and freedom to use non-pilot test subjects. The MAT battery primary display is composed of four separate task windows which are as follows: a monitoring task window which includes gauges and warning lights, a tracking task window for the demands of manual control, a communication task window to simulate air traffic control communications, and a resource management task window which permits maintaining target levels on a fuel management task. In addition, a scheduling task window gives the researcher information about future task demands. The battery also provides the option of manual or automated control of tasks. The task generates performance data for each subtask. The task battery may be paused and onscreen workload rating scales presented to the subject. The MAT battery was designed to use a serially linked second computer to generate the voice messages for the Communications task. The MATREMX program and support files, which are included in the MAT package, were designed to work with the Heath Voice Card (Model HV-2000, available through the Heath Company, Benton Harbor, Michigan 49022); however, the MATREMX program and support files may easily be modified to work with other voice synthesizer or digitizer cards. The MAT battery task computer may also be used independent of the voice computer if no computer synthesized voice messages are desired or if some other method of presenting auditory messages is devised. MAT is written in QuickBasic and assembly language for IBM PC series and compatible computers running MS-DOS. The code in MAT is written for Microsoft QuickBasic 4.5 and Microsoft Macro Assembler 5.1. This package requires a joystick and EGA or VGA color graphics. An 80286, 386, or 486 processor machine is highly recommended. The standard distribution medium for MAT is a 5.25 inch 360K MS-DOS format diskette. The files are compressed using the PKZIP file compression utility. PKUNZIP is included on the distribution diskette. MAT was developed in 1992. IBM PC is a registered trademark of International Business Machines. MS-DOS, Microsoft QuickBasic, and Microsoft Macro Assembler are registered trademarks of Microsoft Corporation. PKZIP and PKUNZIP are registered trademarks of PKWare, Inc.

Targeting Neutrophil Protease-Mediated Degradation of Tsp-1 to Induce Metastatic Dormancy

DTIC Science & Technology

2017-10-01

have decided to use CRISPR -Cas9 mediated gene knockout as it results in complete depletion of gene products. The sequences for gRNAs (Fig. 1B) have...express Tsp-1 receptor CD36 Fig. 1. (A) Tsp-1 receptor CD36 is expressed by tumor cells. (B) Design of CRISPR -Cas9 gRNAs for generating biallelic...DWLPK peptide solubility were created and optimized. For Aim 1, Subtask 2.1: We have decided to use CRISPR -Cas9 as they are more potent in

Extensive Turnover of Compatible Solutes in Cyanobacteria Revealed by Deuterium Oxide (D 2 O) Stable Isotope Probing

DOE PAGES

Baran, Richard; Lau, Rebecca; Bowen, Benjamin P.; ...

2017-01-18

In diverse environments on a global scale cyanobacteria are important primary producers of organic matter. Moreover, while mechanisms of CO 2 fixation are well understood, the distribution of the flow of fixed organic carbon within individual cells and complex microbial communities is less well characterized. To obtain a general overview of metabolism, we describe the use of deuterium oxide (D 2O) to measure deuterium incorporation into the intracellular metabolites of two physiologically diverse cyanobacteria: a terrestrial filamentous strain (Microcoleus vaginatus PCC 9802) and a euryhaline unicellular strain (Synechococcus sp. PCC 7002). D 2O was added to the growth medium duringmore » different phases of the diel cycle. Incorporation of deuterium into metabolites at nonlabile positions, an indicator of metabolite turnover, was assessed using liquid chromatography mass spectrometry. Expectedly, large differences in turnover among metabolites were observed. Some metabolites, such as fatty acids, did not show significant turnover over 12–24 h time periods but did turn over during longer time periods. Unexpectedly, metabolites commonly regarded to act as compatible solutes, including glutamate, glucosylglycerol, and a dihexose, showed extensive turnover compared to most other metabolites already after 12 h, but only during the light phase in the cycle. We observed extensive turnover and found it surprising considering the conventional view on compatible solutes as biosynthetic end points given the relatively slow growth and constant osmotic conditions. Our suggests the possibility of a metabolic sink for some compatible solutes (e.g., into glycogen) that allows for rapid modulation of intracellular osmolarity. To investigate this, uniformly 13C-labeled Synechococcus sp. PCC 7002 were exposed to 12C glucosylglycerol. Following metabolite extraction, amylase treatment of methanol-insoluble polymers revealed 12C labeling of glycogen. Overall, our work shows that D 2O probing is a powerful method for analysis of cyanobacterial metabolism including discovery of novel metabolic processes.« less

De Novo Chromosome Copy Number Variation in Fanconi Anemia-Associated Hematopoietic Defects

DTIC Science & Technology

2012-04-01

Appendix 1. Expansion of monoclonal populations of FA-A hTERT and FA-A + FANCA hTERT cells Appendix 2. Expansion of monoclonal populations of FA...marrow failure (BMF) and pronounced cancer susceptibility. The FA proteins and the major breast cancer susceptibility gene products BRCA1 and BRCA2...Correction of FA-A, FA-C, and FA-D2 hTERT cells with pLenti6.2/V5- FANCA , -FANCC, and FANCD2, respectively. Sub-task 1. Selection and expansion of clonal

The Role of Polycomb Group Gene BMI1 in the Development of Prostate Cancer

DTIC Science & Technology

2012-07-01

16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18 . NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON USAMRMC a. REPORT U b...Completed; Data presented in this report. 11 Task 3 (OF SOW): Sub-task: (3A) Studies in athymic nude mouse xenograft model will be conducted (a) to...to exhibit increased Wnt signaling and TCF-transcriptional activity ( 18 ). We first determined BMI1 levels in HT29 cells and then generated BMI1

DNA Copy Number Signature to Predict Recurrence in Early Stage Ovarian Cancer

DTIC Science & Technology

2016-08-01

AWARD NUMBER: W81XWH-14-1-0194 TITLE: DNA Copy Number Signature to Predict Recurrence in Early-Stage Ovarian Cancer PRINCIPAL INVESTIGATOR...SUBTITLE 5a. CONTRACT NUMBER DNA Copy Number Signature to Predict Recurrence in Early-Stage Ovarian Cancer 5b. GRANT NUMBER W81XWH-14-1-0194 5c. PROGRAM...determine the copy number gain and loss for early stage high grade ovarian cancers through IlluminaHumanOmniExpress-FFPE BeadChip system • Subtask 1 DNA

Structured Analysis and Structured Design for the Logistic Support Analysis (LSA) Task 303 Evaluation of Alternatives and Trade-Off Analysis, LSA Subtask 303.2.2, Trade-Off Between Support System Alternatives and System/Equipment Alternatives

DTIC Science & Technology

1991-01-01

Field 3. Training and Training Devices: a. Factory training b. Instructor and key personnel training c. New equipment training plan d. New equipment...12345678901234567990123456789012345678901234567890123456789� 1. 0016 10 SUPPOR2AILITY ALTEIIIVE TRADE-OFF ANALISIS . 4. + 4" + 4. 4. 4 2. C1.0 111.0 N2.0 1.0 INITIATE

A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS

DTIC Science & Technology

2016-10-01

AWARD NUMBER: W81XWH-15-1-0654 TITLE: A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS...Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...Major Tasks and subtasks: Aim#1: To compare the gut microbiome of subjects with RMS and PPMS. Major Task 1: To seek and obtain HRPO approval Major

A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS

DTIC Science & Technology

2016-10-01

AWARD NUMBER: W81XWH-15-1-0652 TITLE: A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS...0652 A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...SOW, each Aim was subdivided into Major Tasks and subtasks: Aim#1: To compare the gut microbiome of subjects with RMS and PPMS. Major Task 1

An assessment of potential CO2 Sources throughout the Illinois Basin Subtask 5.1 – CO2 Source Assessment Topical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patel, Vinodkumar; O?Brien, Kevin; Korose, Christopher

Large-scale anthropogenic CO2 sources (>100,000 tonnes/year) were catalogued and assessed for the Illinois East Sub-Basin project area. The portfolio of sources is quite diverse, and contains not only fossil-based power generation facilities but also ethanol, chemical, and refinery facilities. Over 60% of the facilities are relatively new (i.e. post year 2000 construction) hence increasing the likelihood that retrofitting the facility with a carbon capture plant is feasible. Two of the facilities have indicated interest in being “early adopters” should the CarbonSAFE project eventually transition to a build and operate phase: the Prairie State Generating Company’s electricity generation facility near Marissa,more » Illinois, and Quasar Syngas, LLC’s Wabash ammonia/direct-reduced iron plant, currently in development north of Terre Haute, Indiana.« less

Supporting dynamic change detection: using the right tool for the task.

PubMed

Vallières, Benoît R; Hodgetts, Helen M; Vachon, François; Tremblay, Sébastien

2016-01-01

Detecting task-relevant changes in a visual scene is necessary for successfully monitoring and managing dynamic command and control situations. Change blindness-the failure to notice visual changes-is an important source of human error. Change History EXplicit (CHEX) is a tool developed to aid change detection and maintain situation awareness; and in the current study we test the generality of its ability to facilitate the detection of changes when this subtask is embedded within a broader dynamic decision-making task. A multitasking air-warfare simulation required participants to perform radar-based subtasks, for which change detection was a necessary aspect of the higher-order goal of protecting one's own ship. In this task, however, CHEX rendered the operator even more vulnerable to attentional failures in change detection and increased perceived workload. Such support was only effective when participants performed a change detection task without concurrent subtasks. Results are interpreted in terms of the NSEEV model of attention behavior (Steelman, McCarley, & Wickens, Hum. Factors 53:142-153, 2011; J. Exp. Psychol. Appl. 19:403-419, 2013), and suggest that decision aids for use in multitasking contexts must be designed to fit within the available workload capacity of the user so that they may truly augment cognition.

Composite body movements modulate numerical cognition: evidence from the motion-numerical compatibility effect

PubMed Central

Cheng, Xiaorong; Ge, Hui; Andoni, Deljfina; Ding, Xianfeng; Fan, Zhao

2015-01-01

A recent hierarchical model of numerical processing, initiated by Fischer and Brugger (2011) and Fischer (2012), suggested that situated factors, such as different body postures and body movements, can influence the magnitude representation and bias numerical processing. Indeed, Loetscher et al. (2008) found that participants’ behavior in a random number generation task was biased by head rotations. More small numbers were reported after leftward than rightward head turns, i.e., a motion-numerical compatibility effect. Here, by carrying out two experiments, we explored whether similar motion-numerical compatibility effects exist for movements of other important body components, e.g., arms, and for composite body movements as well, which are basis for complex human activities in many ecologically meaningful situations. In Experiment 1, a motion-numerical compatibility effect was observed for lateral rotations of two body components, i.e., the head and arms. Relatively large numbers were reported after making rightward compared to leftward movements for both lateral head and arm turns. The motion-numerical compatibility effect was observed again in Experiment 2 when participants were asked to perform composite body movements of congruent movement directions, e.g., simultaneous head left turns and arm left turns. However, it disappeared when the movement directions were incongruent, e.g., simultaneous head left turns and arm right turns. Taken together, our results extended Loetscher et al.’s (2008) finding by demonstrating that their effect is effector-general and exists for arm movements. Moreover, our study reveals for the first time that the impact of spatial information on numerical processing induced by each of the two sensorimotor-based situated factors, e.g., a lateral head turn and a lateral arm turn, can cancel each other out. PMID:26594188

CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer

PubMed Central

Thompson, Deborah J; O'Mara, Tracy A; Glubb, Dylan M; Painter, Jodie N; Cheng, Timothy; Folkerd, Elizabeth; Doody, Deborah; Dennis, Joe; Webb, Penelope M; Gorman, Maggie; Martin, Lynn; Hodgson, Shirley; Michailidou, Kyriaki; Tyrer, Jonathan P; Maranian, Mel J; Hall, Per; Czene, Kamila; Darabi, Hatef; Li, Jingmei; Fasching, Peter A; Hein, Alexander; Beckmann, Matthias W; Ekici, Arif B; Dörk, Thilo; Hillemanns, Peter; Dürst, Matthias; Runnebaum, Ingo; Zhao, Hui; Depreeuw, Jeroen; Schrauwen, Stefanie; Amant, Frederic; Goode, Ellen L; Fridley, Brooke L; Dowdy, Sean C; Winham, Stacey J; Salvesen, Helga B; Trovik, Jone; Njolstad, Tormund S; Werner, Henrica M J; Ashton, Katie; Proietto, Tony; Otton, Geoffrey; Carvajal-Carmona, Luis; Tham, Emma; Liu, Tao; Mints, Miriam; Scott, Rodney J; McEvoy, Mark; Attia, John; Holliday, Elizabeth G; Montgomery, Grant W; Martin, Nicholas G; Nyholt, Dale R; Henders, Anjali K; Hopper, John L; Traficante, Nadia; Ruebner, Matthias; Swerdlow, Anthony J; Burwinkel, Barbara; Brenner, Hermann; Meindl, Alfons; Brauch, Hiltrud; Lindblom, Annika; Lambrechts, Diether; Chang-Claude, Jenny; Couch, Fergus J; Giles, Graham G; Kristensen, Vessela N; Cox, Angela; Bolla, Manjeet K; Wang, Qin; Bojesen, Stig E; Shah, Mitul; Luben, Robert; Khaw, Kay-Tee; Pharoah, Paul D P; Dunning, Alison M; Tomlinson, Ian; Dowsett, Mitch; Easton, Douglas F; Spurdle, Amanda B

2016-01-01

Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and with estradiol (E2) concentrations. We analyzed 2937 single nucleotide polymorphisms (SNPs) in 6608 endometrial cancer cases and 37 925 controls and report the first genome wide-significant association between endometrial cancer and a CYP19A1 SNP (rs727479 in intron 2, P=4.8×10−11). SNP rs727479 was also among those most strongly associated with circulating E2 concentrations in 2767 post-menopausal controls (P=7.4×10−8). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11–1.21) is compatible with that predicted by the observed effect on E2 concentrations (1.09, CI=1.03–1.21), consistent with the hypothesis that endometrial cancer risk is driven by E2. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associations with rs727479 were stronger among women with a higher BMI (Pinteraction=0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction. PMID:26574572

High Speed Research (HSR) Multi-Year Summary Report for Calendar Years 1995-1999

NASA Technical Reports Server (NTRS)

Baker, Myles; Boyd, William

1999-01-01

The Aeroelasticity Task is intended to provide demonstrated technology readiness to predict and improve flutter characteristics of an HSCT configuration. This requires aerodynamic codes that are applicable to the wide range of flight regimes in which the HSCT will operate, and are suitable to provide the higher fidelity required for evaluation of aeroservoelastic coupling effects. Prediction of these characteristics will result in reduced airplane weight and risk associated with a highly flexible, low-aspect ratio supersonic airplane with narrow fuselage, relatively thin wings, and heavy engines. This Task is subdivided into three subtasks. The first subtask includes the design, fabrication, and testing of wind-tunnel models suitable to provide an experimental database relevant to HSCT configurations. The second subtask includes validation of candidate unsteady aerodynamic codes, applicable in the Mach and frequency ranges of interest for the HSCT, through analysis test correlation with the test data. The third subtask includes efforts to develop and enhance these codes for application to HSCT configurations. The wind tunnel models designed and constructed during this program furnished data which were useful for the analysis test correlation work but there were shortcomings. There was initial uncertainty in the proper tunnel configuration for testing, there was a need for higher quality measured model geometry, and there was a need for better measured model displacements in the test data. One of the models exhibited changes in its dynamic characteristics during testing. Model design efforts were hampered by a need for more and earlier analysis support and better knowledge of material properties. Success of the analysis test correlation work was somewhat muted by the uncertainties in the wind tunnel model data. The planned extent of the test data was not achieved, partly due to the delays in the model design and fabrication which could not be extended due to termination of the HSR program.

Orbit Transfer Rocket Engine Technology Program, Advanced Engine Study Task D.6

DTIC Science & Technology

1992-02-28

l!J~iliiJl 1. Report No. 2. Government Accession No. 3 . Recipient’s Catalog No. NASA 187215 4. Title and Subtitle 5. Report Date ORBIT TRANSFER ROCKET...Engine Study, three primary subtasks were accomplished: 1) Design and Parametric Data, 2) Engine Requirement Variation Studies, and 3 ) Vehicle Study...Mixture Ratio Parametrics 18 3 . Thrust Parametrics Off-Design Mixture Ratio Scans 22 4. Expansion Area Ratio Parametrics 24 5. OTV 20 klbf Engine Off

Improving Attachments of Non-Invasive (Type III) Electronic Data Loggers to Cetaceans

DTIC Science & Technology

2015-09-30

animals in human care will be performed to test and validate this approach. The cadaver trials will enable controlled testing to failure or with both...quantitative metrics and analysis tools to assess the impact of a tag on the animal . Here we will present: 1) the characterization of the mechanical...fine scale motion analysis for swimming animals . 2 APPROACH Our approach is divided into four subtasks: Task 1: Forces and failure modes

Flexible Regenerative Nanoelectronics for Advanced Peripheral Neural Interfaces

DTIC Science & Technology

2017-10-01

these materials will be developed based on 3D printing . Page 4 Task 3. Construct nerve guidance scaffolds comprising of embedded mesh electrodes with...Develop photo mask patterning methods. 1-9 In progress 50% Subtask 2.2.2. Develop 3D printing patterning methods. 9-18 9/1/2017 Milestone(s...research into patterning techniques, we found that 10% gelatin methacrylate (GelMA) base gel was the best for performing 3D printing of the gels

Compatibility of motion facilitates visuomotor synchronization.

PubMed

Hove, Michael J; Spivey, Michael J; Krumhansl, Carol L

2010-12-01

Prior research indicates that synchronized tapping performance is very poor with flashing visual stimuli compared with auditory stimuli. Three finger-tapping experiments compared flashing visual metronomes with visual metronomes containing a spatial component, either compatible, incompatible, or orthogonal to the tapping action. In Experiment 1, synchronization success rates increased dramatically for spatiotemporal sequences of both geometric and biological forms over flashing sequences. In Experiment 2, synchronization performance was best when target sequences and movements were directionally compatible (i.e., simultaneously down), followed by orthogonal stimuli, and was poorest for incompatible moving stimuli and flashing stimuli. In Experiment 3, synchronization performance was best with auditory sequences, followed by compatible moving stimuli, and was worst for flashing and fading stimuli. Results indicate that visuomotor synchronization improves dramatically with compatible spatial information. However, an auditory advantage in sensorimotor synchronization persists.

Ge1-xSnx alloys synthesized by ion implantation and pulsed laser melting

NASA Astrophysics Data System (ADS)

Gao, Kun; Prucnal, S.; Huebner, R.; Baehtz, C.; Skorupa, I.; Wang, Yutian; Skorupa, W.; Helm, M.; Zhou, Shengqiang

2014-07-01

The tunable bandgap and the high carrier mobility of Ge1-xSnx alloys stimulate a large effort for bandgap and strain engineering for Ge based materials using silicon compatible technology. In this Letter, we present the fabrication of highly mismatched Ge1-xSnx alloys by ion implantation and pulsed laser melting with Sn concentration ranging from 0.5 at. % up to 1.5 at. %. According to the structural investigations, the formed Ge1-xSnx alloys are monocrystalline with high Sn-incorporation rate. The shrinkage of the bandgap of Ge1-xSnx alloys with increasing Sn content is proven by the red-shift of the E1 and E1 + Δ1 critical points in spectroscopic ellipsometry. Our investigation provides a chip technology compatible route to prepare high quality monocrystalline Ge1-xSnx alloys.

Pulsed laser deposition of piezoelectric lead zirconate titanate thin films maintaining a post-CMOS compatible thermal budget

NASA Astrophysics Data System (ADS)

Schatz, A.; Pantel, D.; Hanemann, T.

2017-09-01

Integration of lead zirconate titanate (Pb[Zrx,Ti1-x]O3 - PZT) thin films on complementary metal-oxide semiconductor substrates (CMOS) is difficult due to the usually high crystallization temperature of the piezoelectric perovskite PZT phase, which harms the CMOS circuits. In this work, a wafer-scale pulsed laser deposition tool was used to grow 1 μm thick PZT thin films on 150 mm diameter silicon wafers. Three different routes towards a post-CMOS compatible deposition process were investigated, maintaining a post-CMOS compatible thermal budget limit of 445 °C for 1 h (or 420 °C for 6 h). By crystallizing the perovskite LaNiO3 seed layer at 445 °C, the PZT deposition temperature can be lowered to below 400 °C, yielding a transverse piezoelectric coefficient e31,f of -9.3 C/m2. With the same procedure, applying a slightly higher PZT deposition temperature of 420 °C, an e31,f of -10.3 C/m2 can be reached. The low leakage current density of below 3 × 10-6 A/cm2 at 200 kV/cm allows for application of the post-CMOS compatible PZT thin films in low power micro-electro-mechanical-systems actuators.

Crab Nebula: Five-year Observation with ARGO-YBJ

NASA Astrophysics Data System (ADS)

Bartoli, B.; Bernardini, P.; Bi, X. J.; Branchini, P.; Budano, A.; Camarri, P.; Cao, Z.; Cardarelli, R.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Creti, P.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liguori, G.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Martello, D.; Mastroianni, S.; Montini, P.; Ning, C. C.; Panareo, M.; Perrone, L.; Pistilli, P.; Ruggieri, F.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Zizzi, G.; ARGO-YBJ Collaboration; Striani, E.

2015-01-01

The ARGO-YBJ air shower detector monitored the Crab Nebula gamma-ray emission from 2007 November to 2013 February. The integrated signal, consisting of ~3.3 × 105 events, reached the statistical significance of 21.1 standard deviations. The obtained energy spectrum in the energy range 0.3-20 TeV can be described by a power law function dN/dE = I 0 (E/2 TeV)-α, with a flux normalization I 0 = (5.2 ± 0.2) × 10-12 photons cm-2 s-1 TeV-1 and α = 2.63 ± 0.05, corresponding to an integrated flux above 1 TeV of 1.97 × 10-11 photons cm-2 s-1. The systematic error is estimated to be less than 30% for the flux normalization and 0.06 for the spectral index. Assuming a power law spectrum with an exponential cutoff dN/dE = I 0 (E/2 TeV)-α exp (-E/E cut), the lower limit of the cutoff energy E cut is 12 TeV, at 90% confidence level. Our extended data set allows the study of the TeV emission over long timescales. Over five years, the light curve of the Crab Nebula in 200-day bins is compatible with a steady emission with a probability of 7.3 × 10-2. A correlated analysis with Fermi-LAT data over ~4.5 yr using the light curves of the two experiments gives a Pearson correlation coefficient r = 0.56 ± 0.22. Concerning flux variations on timescales of days, a "blind" search for flares with a duration of 1-15 days gives no excess with a significance higher than four standard deviations. The average rate measured by ARGO-YBJ during the three most powerful flares detected by Fermi-LAT is 205 ± 91 photons day-1, consistent with the average value of 137 ± 10 day-1.

Random Number Generation for High Performance Computing

DTIC Science & Technology

2015-01-01

number streams, a quality metric for the parallel random number streams. * * * * * Atty. Dkt . No.: 5660-14400 Customer No. 35690 Eric B. Meyertons...responsibility to ensure timely payment of maintenance fees when due. Pagel of3 PTOL-85 (Rev. 02/11) Atty. Dkt . No.: 5660-14400 Page 1 Meyertons...with each subtask executed by a separate thread or process (henceforth, process). Each process has Atty. Dkt . No.: 5660-14400 Page 2 Meyertons

Coal gasification systems engineering and analysis. Appendix A: Coal gasification catalog

NASA Technical Reports Server (NTRS)

1980-01-01

The scope of work in preparing the Coal Gasification Data Catalog included the following subtasks: (1) candidate system subsystem definition, (2) raw materials analysis, (3) market analysis for by-products, (4) alternate products analysis, (5) preliminary integrated facility requirements. Definition of candidate systems/subsystems includes the identity of and alternates for each process unit, raw material requirements, and the cost and design drivers for each process design.

Babcock and Wilcox assessment of the Pratt and Whitney XNR2000

NASA Technical Reports Server (NTRS)

Westerman, Kurt O.; Scoles, Stephen W.; Jensen, R. R.; Rodes, J. R.; Ales, M. W.

1993-01-01

Babcock & Wilcox performed four subtasks related to the assessment of the Pratt & Whitney XNR2000 nuclear reactor as follows: (1) cermet fuel element fabricability assessment; (2) mechanical design review of the reactor system; (3) neutronic analysis review; and (4) safety assessment. The results of the mechanical and physics reviews have been integrated into the reactor design. The results of the fuel and safety assessments are presented.

Evidence of genetic susceptibility to infectious mononucleosis: a twin study

PubMed Central

HWANG, A. E.; HAMILTON, A. S.; COCKBURN, M. G.; AMBINDER, R.; ZADNICK, J.; BROWN, E. E.; MACK, T. M.; COZEN, W.

2013-01-01

SUMMARY Infectious mononucleosis is a clinical manifestation of primary Epstein–Barr virus infection. It is unknown whether genetic factors contribute to risk. To assess heritability, we compared disease concordance in monozygotic to dizygotic twin pairs from the population-based California Twin Program and assessed the risk to initially unaffected co-twins. One member of 611 and both members of 58 twin pairs reported a history of infectious mononucleosis. Pairwise concordance in monozygotic and dizygotic pairs was respectively 12·1% [standard error (s.e.)=1·9%] and 6·1% (s.e.=1·2%). The relative risk (hazard ratio) of monozygotic compared to dizygotic unaffected co-twins of cases was 1·9 [95% confidence interval (CI) 1·1–3·4, P=0·03], over the follow-up period. When the analysis was restricted to same-sex twin pairs, that estimate was 2·5 (95% CI 1·2–5·3, P=0·02). The results are compatible with a heritable contribution to the risk of infectious mononucleosis. PMID:22152594

Evidence of genetic susceptibility to infectious mononucleosis: a twin study.

PubMed

Hwang, A E; Hamilton, A S; Cockburn, M G; Ambinder, R; Zadnick, J; Brown, E E; Mack, T M; Cozen, W

2012-11-01

Infectious mononucleosis is a clinical manifestation of primary Epstein-Barr virus infection. It is unknown whether genetic factors contribute to risk. To assess heritability, we compared disease concordance in monozygotic to dizygotic twin pairs from the population-based California Twin Program and assessed the risk to initially unaffected co-twins. One member of 611 and both members of 58 twin pairs reported a history of infectious mononucleosis. Pairwise concordance in monozygotic and dizygotic pairs was respectively 12·1% [standard error (s.e.)=1·9%] and 6·1% (s.e.=1·2%). The relative risk (hazard ratio) of monozygotic compared to dizygotic unaffected co-twins of cases was 1·9 [95% confidence interval (CI) 1·1-3·4, P=0·03], over the follow-up period. When the analysis was restricted to same-sex twin pairs, that estimate was 2·5 (95% CI 1·2-5·3, P=0·02). The results are compatible with a heritable contribution to the risk of infectious mononucleosis.

Electromagnetic Compatibility (EMC) in Microelectronics.

DTIC Science & Technology

1983-02-01

Fault Tree Analysis", System Saftey Symposium, June 8-9, 1965, Seattle: The Boeing Company . 12. Fussell, J.B., "Fault Tree Analysis-Concepts and...procedure for assessing EMC in microelectronics and for applying DD, 1473 EOiTO OP I, NOV6 IS OESOL.ETE UNCLASSIFIED SECURITY CLASSIFICATION OF THIS...CRITERIA 2.1 Background 2 2.2 The Probabilistic Nature of EMC 2 2.3 The Probabilistic Approach 5 2.4 The Compatibility Factor 6 3 APPLYING PROBABILISTIC

Earth Observatory Satellite system definition study. Report no. 3: Design/cost tradeoff studies. Appendix E: EOS program supporting system. Part 1: System trade studies no. 1 through 8

NASA Technical Reports Server (NTRS)

1974-01-01

The design requirements and associated cost impacts for using the space shuttle to deliver the Earth Observatory Satellite (EOS) are identified. The additional impact of achieving full compatibility for resupply and retrieval is considered. Based on the results of the analysis, it is concluded that the EOS-Shuttle compatibility can be realized with reasonable spacecraft weight and cost penalties. Inherent space shuttle capabilities are adequate to meet the requirements of all missions except E and F. Mission E (Tiros 0) may be accommodated by either an EOS orbit transfer capability or a tug. The tug appears to be the only viable approach to satisfying the mission F (SEOS) requirements.

Early Intervention to Reduce Alcohol Misuse and Abuse in the Ohio Army National Guard

DTIC Science & Technology

2015-09-01

the content of the WT-BI intervention for NG soldiers, the proposed study will screen ~ 3,100 individuals over the three year enrollment period as...months. After tailoring the content of the MT- BI intervention for National Guard soldiers, the proposed study will screen ~ 3,100 different...all study personnel in Year 1, with ongoing trainings held each year as needed. 5 Subtask 2 Starting in the 4th quarter of Year 1 through Year 4

Targeting Autophagy in the Tumor Stroma to Eradicate Breast Cancer

DTIC Science & Technology

2013-09-01

initiated. One potential caveat that has arisen is that fibroblast specific protein (FSP) may be expressed at low levels in late stage PyMT tumor...digestion solution per 5g of tumor tissue) 1.5 mg/ml Collagenase (from 100X stock solution) 125 U/ml Hyaluronidase (from 100X stock solution) MMF media...g. Determine the latency period to the onset of primary tumor formation and metastasis for recipient mice generated in subtask 1f. At selected

Test plan. Task 5, subtask 5.2: Early on-orbit TPSdebris impact tests

NASA Technical Reports Server (NTRS)

Greenberg, H. S.

1994-01-01

The limitation of damage to, and survival of, the cryogenic tankage during the on-orbit stay despite potential impact of orbital debris, may be a significant discriminator in the RHCTS trade studies described in the TA-1 trade study plan (ref. RHCTS-TSP-1) dated July 29, 1994. The objective of this early phase of an overall debris impact test program is to provide the data to support assessment of the relative suitability of integral and non integral tanks.

Optical and Electrical Characterization of Multiply Doped Silicon: A Study of the Si:(In, A1) System.

DTIC Science & Technology

1984-02-01

RFWAL-TR-83-4108 UNCLASSIFIED F33 5-8i--50 5 S F/ 2/12 NL Lmmhhhhml 1.2 11. . .4 ’sqo ItI -.9 .9 D’ ’-3.,= 1111 III1 ,1 MICROCOP REOUTO TES3 AR...is compatible with conventional charge-coupled device (CCD) signal processing, dopant and impurity uniformity is inherently superior to compound

Impact of molecular solvophobicity vs. solvophilicity on device performances of dimeric perylene diimide based solution-processed non-fullerene organic solar cells.

PubMed

Lu, Zhenhuan; Zhang, Xin; Zhan, Chuanlang; Jiang, Bo; Zhang, Xinliang; Chen, Lili; Yao, Jiannian

2013-07-21

Because of their outstanding molecular optoelectronic properties, perylene diimides (PDIs) are promising alternatives to the commonly used PCBM. However, the overly strong aggregation ability, poor solution-processability and compatibility of PDIs severely limit their photovoltaic applications. We turned to borrowing the amphiphile concept to improve these supramolecular properties. Practically, we fine-tuned the molecular solvophobicity with respect to the molecular solvophilicity, e.g. F(solvophob/solvophil), by changing the number of the weakly solvophobic 2-methoxyethoxyl (EG) groups in the bay-region of the thienyl-bridged dimeric PDI backbone, forming three PDI dimers of Bis-PDI-T (0 EG), Bis-PDI-T-EG (2 EG) and Bis-PDI-T-di-EG (4 EG) (Scheme 1). The photovoltaic properties using these dimers as the solution-processed non-fullerene electron-acceptor and P3HT as the electron-donor were investigated via the device configuration of ITO/PEDOT:PSS/P3HT:PDI dimer/Ca/Al. Bis-PDI-T exhibited overly strong aggregation ability and very poor solution-processability, which severely limited compatibility, giving a very poor power conversion efficiency (PCE) of 0.007%. When two EG groups were attached at the 1,1'-positions, the resulted Bis-PDI-T-EG showed dramatically reduced aggregation ability, improved solution-processability, compatibility and proper phase separation. Small sized phases (∼20 nm) dominated in the active layer and the best PCE was increased to 0.39%. When four solvophobic EG functions were introduced, affording Bis-PDI-T-di-EG with excellent supramolecular properties, particularly, the improvement of the phase separation with an increased phase size of 24 nm and the enhanced electron and hole mobilities, by 2-4 times, with respect to that of Bis-PDI-T-EG. The best PCE was further enhanced to 0.88%. After using 1-chloronaphthalene as the co-solvent of 1,2-dichlorobenzene to further improve the compatibility, the PCE was improved further up to 0.41% for Bis-PDI-T, 0.76% for Bis-PDI-T-EG and 1.54% for Bis-PDI-T-di-EG.

Subtask 12B1: Welding development for V-Cr-Ti alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, J.F.; Goodwin, G.M.; Grossbeck, M.L.

1995-03-01

Development of the metallurgical and technological basis for the welding of thick sections of V-Cr-Ti alloys. The weldability and weldment properties of the V-5Cr-5Ti alloy have been evaluated. Results for the Sigmajig test of the vanadium alloy were similar to the cracking resistance of stainless steels, and indicates hot-cracking is unlikely to be a problem. Subsize Charpy test results for GTA weld metal in the as-welded condition have shown a significant reduction in toughness compared to the base metal. The weld metal toughness properties were restored to approximately that of the base metal after exposure to a PWHT 950{degrees}C. Themore » subsize Charpy toughness results for the EB weld metal from this same heat of vanadium alloy has shown significant improvement in properties compared to the GTA weld metal and the base metal. Further testing and analysis will be conducted to more fully characterize the properties of weld metal for each welding process and develop a basic understanding of the cause of the toughness decrease in the GTA welds. 5 figs., 1 tab.« less

Pilot study on real-time motion detection in UAS video data by human observer and image exploitation algorithm

NASA Astrophysics Data System (ADS)

Hild, Jutta; Krüger, Wolfgang; Brüstle, Stefan; Trantelle, Patrick; Unmüßig, Gabriel; Voit, Michael; Heinze, Norbert; Peinsipp-Byma, Elisabeth; Beyerer, Jürgen

2017-05-01

Real-time motion video analysis is a challenging and exhausting task for the human observer, particularly in safety and security critical domains. Hence, customized video analysis systems providing functions for the analysis of subtasks like motion detection or target tracking are welcome. While such automated algorithms relieve the human operators from performing basic subtasks, they impose additional interaction duties on them. Prior work shows that, e.g., for interaction with target tracking algorithms, a gaze-enhanced user interface is beneficial. In this contribution, we present an investigation on interaction with an independent motion detection (IDM) algorithm. Besides identifying an appropriate interaction technique for the user interface - again, we compare gaze-based and traditional mouse-based interaction - we focus on the benefit an IDM algorithm might provide for an UAS video analyst. In a pilot study, we exposed ten subjects to the task of moving target detection in UAS video data twice, once performing with automatic support, once performing without it. We compare the two conditions considering performance in terms of effectiveness (correct target selections). Additionally, we report perceived workload (measured using the NASA-TLX questionnaire) and user satisfaction (measured using the ISO 9241-411 questionnaire). The results show that a combination of gaze input and automated IDM algorithm provides valuable support for the human observer, increasing the number of correct target selections up to 62% and reducing workload at the same time.

High-performance Schottky heterojunction photodetector with directly grown graphene nanowalls as electrodes.

PubMed

Shen, Jun; Liu, Xiangzhi; Song, Xuefen; Li, Xinming; Wang, Jun; Zhou, Quan; Luo, Shi; Feng, Wenlin; Wei, Xingzhan; Lu, Shirong; Feng, Shuanglong; Du, Chunlei; Wang, Yuefeng; Shi, Haofei; Wei, Dapeng

2017-05-11

Schottky heterojunctions based on graphene-silicon structures are promising for high-performance photodetectors. However, existing fabrication processes adopt transferred graphene as electrodes, limiting process compatibility and generating pollution because of the metal catalyst. In this report, photodetectors are fabricated using directly grown graphene nanowalls (GNWs) as electrodes. Due to the metal-free growth process, GNWs-Si heterojunctions with an ultralow measured current noise of 3.1 fA Hz -1/2 are obtained, and the as-prepared photodetectors demonstrate specific detectivities of 5.88 × 10 13 cm Hz 1/2 W -1 and 2.27 × 10 14 cm Hz 1/2 W -1 based on the measured and calculated noise current, respectively, under ambient conditions. These are among the highest reported values for planar silicon Schottky photodetectors. In addition, an on/off ratio of 2 × 10 7 , time response of 40 μs, cut-off frequency of 8.5 kHz and responsivity of 0.52 A W -1 are simultaneously realized. The ultralow current noise is attributed to the excellent junction quality with a barrier height of 0.69 eV and an ideal factor of 1.18. Furthermore, obvious infrared photoresponse is observed in blackbody tests, and potential applications based on the photo-thermionic effect are discussed.

The 12C/ 13C isotopic ratio in Titan hydrocarbons from Cassini/CIRS infrared spectra

NASA Astrophysics Data System (ADS)

Nixon, C. A.; Achterberg, R. K.; Vinatier, S.; Bézard, B.; Coustenis, A.; Irwin, P. G. J.; Teanby, N. A.; de Kok, R.; Romani, P. N.; Jennings, D. E.; Bjoraker, G. L.; Flasar, F. M.

2008-06-01

We have analyzed infrared spectra of Titan recorded by the Cassini Composite Infrared Spectrometer (CIRS) to measure the isotopic ratio 12C/ 13C in each of three chemical species in Titan's stratosphere: CH 4, C 2H 2 and C 2H 6. This is the first measurement of 12C/ 13C in any C 2 molecule on Titan, and the first measurement of 12CH 4/ 13CH 4 (non-deuterated) on Titan by remote sensing. Our spectra cover five widely-spaced latitudes, 65° S to 71° N and we have searched for both latitude variability of 12C/ 13C within a given species, and also for differences between the 12C/ 13C in the three gases. For CH 4 alone, we find C12/C13=76.6±2.7 (1- σ), essentially in agreement with the 12CH 4/ 13CH 4 measured by the Huygens Gas Chromatograph/Mass Spectrometer instrument (GCMS) [Niemann, H.B., and 17 colleagues, 2005. Nature 438, 779-784]: 82.3±1.0, and also with measured values in H 13CN and 13CH 3D by CIRS at lower precision [Bézard, B., Nixon, C., Kleiner, I., Jennings, D., 2007. Icarus 191, 397-400; Vinatier, S., Bézard, B., Nixon, C., 2007. Icarus 191, 712-721]. For the C 2 species, we find C12/C13=84.8±3.2 in C 2H 2 and 89.8±7.3 in C 2H 6, a possible trend of increasingly value with molecular mass, although these values are both compatible with the Huygens GCMS value to within error bars. There are no convincing trends in latitude. Combining all fifteen measurements, we obtain a value of C12/C13=80.8±2.0, also compatible with GCMS. Therefore, the evidence is mounting that 12C/ 13C is some 8% lower on Titan than on the Earth (88.9, inorganic standard), and lower than typical for the outer planets ( 88±7 [Sada, P.V., McCabe, G.H., Bjoraker, G.L., Jennings, D.E., Reuter, D.C., 1996. Astrophys. J. 472, 903-907]). There is no current model for this enrichment, and we discuss several mechanisms that may be at work.

Technology Assessment of the DACS/MERADCOM Prestaged Ammunition Loading System (PALS) Concept Study.

DTIC Science & Technology

1980-08-01

American Railroads (AAR) and Coast 1-2 Arthurl) little.lnc - Guard (CC) regulations for the shipment of ammunition. The system must be compatible with...to meet Association of American Railroads (AAR) and Coast Guard (CC) regulations for the shipment of ammunition. The system must be compatible with...unloaded u ler field conditions? (4) Can the PALS meet AA and CC regulations for the safe shipment of ammunition in commercial cargo containers? (5

Advanced obstacle avoidance for a laser based wheelchair using optimised Bayesian neural networks.

PubMed

Trieu, Hoang T; Nguyen, Hung T; Willey, Keith

2008-01-01

In this paper we present an advanced method of obstacle avoidance for a laser based intelligent wheelchair using optimized Bayesian neural networks. Three neural networks are designed for three separate sub-tasks: passing through a door way, corridor and wall following and general obstacle avoidance. The accurate usable accessible space is determined by including the actual wheelchair dimensions in a real-time map used as inputs to each networks. Data acquisitions are performed separately to collect the patterns required for specified sub-tasks. Bayesian frame work is used to determine the optimal neural network structure in each case. Then these networks are trained under the supervision of Bayesian rule. Experiment results showed that compare to the VFH algorithm our neural networks navigated a smoother path following a near optimum trajectory.

Radiative corrections to the solar lepton mixing sum rule

NASA Astrophysics Data System (ADS)

Zhang, Jue; Zhou, Shun

2016-08-01

The simple correlation among three lepton flavor mixing angles ( θ 12, θ 13, θ 23) and the leptonic Dirac CP-violating phase δ is conventionally called a sum rule of lepton flavor mixing, which may be derived from a class of neutrino mass models with flavor symmetries. In this paper, we consider the solar lepton mixing sum rule θ 12 ≈ θ 12 ν + θ 13 cos δ, where θ 12 ν stems from a constant mixing pattern in the neutrino sector and takes the value of θ 12 ν = 45 ° for the bi-maximal mixing (BM), {θ}_{12}^{ν } = { tan}^{-1}(1/√{2}) ≈ 35.3° for the tri-bimaximal mixing (TBM) or {θ}_{12}^{ν } = { tan}^{-1}(1/√{5+1}) ≈ 31.7° for the golden-ratio mixing (GR), and investigate the renormalization-group (RG) running effects on lepton flavor mixing parameters when this sum rule is assumed at a superhigh-energy scale. For illustration, we work within the framework of the minimal supersymmetric standard model (MSSM), and implement the Bayesian approach to explore the posterior distribution of δ at the low-energy scale, which becomes quite broad when the RG running effects are significant. Moreover, we also discuss the compatibility of the above three mixing scenarios with current neutrino oscillation data, and observe that radiative corrections can increase such a compatibility for the BM scenario, resulting in a weaker preference for the TBM and GR ones.

Mobile, Multi-modal, Label-Free Imaging Probe Analysis of Choroidal Oximetry and Retinal Hypoxia

DTIC Science & Technology

2015-10-01

eyes and image choroidal vessels/capillaries using CARS intravital microscopy Subtask 3: Measure oxy-hemoglobin levels in PBI test and control eyes...AWARD NUMBER: W81XWH-14-1-0537 TITLE: Mobile, Multi-modal, Label-Free Imaging Probe Analysis of Choroidal Oximetry and Retinal Hypoxia...4. TITLE AND SUBTITLE Mobile, Multimodal, Label-Free Imaging Probe Analysis of Choroidal Oximetry and Retinal Hypoxia 5a. CONTRACT NUMBER W81XWH

Micro-Devices Using Resistance Change Materials (MODERN Materials)

DTIC Science & Technology

2014-03-07

subcontractors/co-PIs on this program Taskl; subtaskl Design of micro-devices based on resistance change materials Taskl; subtask2 Fabrication and process...currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE ( DD -MM-YYYY) 07/03/2014 2. REPORT TYPE Final...Technical Report 3. DATES COVERED (From Jan 2013-May 2014 To) 4. TITLE AND SUBTITLE Micro Devices based on Resistance Change Materials 5a

Information Presentation: Human Research Program - Space Human Factors and Habitability, Space Human Factors Engineering Project

NASA Technical Reports Server (NTRS)

Holden, Kristina L.; Sandor, Aniko; Thompson, Shelby G.; Kaiser, Mary K.; McCann, Robert S.; Begault, D. R.; Adelstein, B. D.; Beutter, B. R.; Wenzel, E. M.; Godfroy, M.;

Subtask 3.9 - Direct Coal Liquefaction Process Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aulich, Ted; Sharma, Ramesh

The Energy and Environmental Research Center (EERC), in partnership with the U.S. Department of Energy (DOE) and Accelergy Corporation, an advanced fuels developer with technologies exclusively licensed from ExxonMobil, undertook Subtask 3.9 to design, build, and preliminarily operate a bench-scale direct coal liquefaction (DCL) system capable of converting 45 pounds/hour of pulverized, dried coal to a liquid suitable for upgrading to fuels and/or chemicals. Fabrication and installation of the DCL system and an accompanying distillation system for off-line fractionation of raw coal liquids into 1) a naphtha middle distillate stream for upgrading and 2) a recycle stream was completed inmore » May 2012. Shakedown of the system was initiated in July 2012. In addition to completing fabrication of the DCL system, the project also produced a 500-milliliter sample of jet fuel derived in part from direct liquefaction of Illinois No. 6 coal, and submitted the sample to the Air Force Research Laboratory (AFRL) at Wright Patterson Air Force Base, Dayton, Ohio, for evaluation. The sample was confirmed by AFRL to be in compliance with all U.S. Air Force-prescribed alternative aviation fuel initial screening criteria.« less

Calcination/dissolution chemistry development Fiscal year 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Delegard, C.H.

1995-09-01

The task {open_quotes}IPC Liaison and Chemistry of Thermal Reconstitution{close_quotes} is a $300,000 program that was conducted in Fiscal Year (FY) 1995 with U.S. Department of Energy (DOE) Office of Research and Development (EM-53) Efficient Separations and Processing Crosscutting Program supported under technical task plan (TTP) RL4-3-20-04. The principal investigator was Cal Delegard of the Westinghouse Hanford Company (WHC). The task encompassed the following two subtasks related to the chemistry of alkaline Hanford Site tank waste: (1) Technical Liaison with the Institute of Physical Chemistry of the Russian Academy of Science (IPC/RAS) and its research into the chemistry of transuranic elementsmore » (TRU) and technetium (Tc) in alkaline media. (2) Laboratory investigation of the chemistry of calcination/dissolution (C/D) (or thermal reconstitution) as an alternative to the present reference Hanford Site tank waste pretreatment flowsheet, Enhanced Sludge Washing (ESW). This report fulfills the milestone for the C/D subtask to {open_quotes}Provide End-of-Year Report on C/D Laboratory Test Results{close_quotes} due 30 September 1995. A companion report, fulfilling the milestone to provide an end-of-year report on the IPC/RAS liaison, also has been prepared.« less

Design of a New Fused-Ring Electron Acceptor with Excellent Compatibility to Wide-Bandgap Polymer Donors for High-Performance Organic Photovoltaics.

PubMed

Liu, Wenrui; Zhang, Jianyun; Zhou, Zichun; Zhang, Dongyang; Zhang, Yuan; Xu, Shengjie; Zhu, Xiaozhang

2018-05-16

Fused-ring electron acceptors (FREAs) have recently received intensive attention. Besides the continuing development of new FREAs, the demand for FREAs featuring good compatibility to donor materials is becoming more and more urgent, which is highly desirable for screening donor materials and achieving new breakthroughs. In this work, a new FREA is developed, ZITI, featuring an octacyclic dithienocyclopentaindenoindene central core. The core is designed by linking 2,7-dithienyl substituents and indenoindene with small methylene groups, in which the indeno[1,2-b]thiophene-2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile part provides a large and unoccupied π-surface. Most notably, ZITI possesses an excellent compatibility with commercially available polymer donors, delivering very high power conversion efficiencies of over 13%. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Human Factors Study of the Clothe the Soldier Temperate Combat Glove

DTIC Science & Technology

2000-03-01

Thermal Comfort ................................................................. ..................................... 10...26 - 5. 1.20 Task Performance - FIBUA I Fire & Movement................... . ................. . . ....... . . . . .. 26 5. 1.2 J Thermal Comfort ................... . . ........................... . ... ............. .... . .. . ......... . . . .. .. . 27...summarized in the following sections. 1. Fit 7. Clinical Hand Tests 2. Accessibility I Adjustability 8. Thermal Comfort 3. Compatibility

Note: Commercial SQUID magnetometer-compatible NMR probe and its application for studying a quantum magnet.

PubMed

Vennemann, T; Jeong, M; Yoon, D; Magrez, A; Berger, H; Yang, L; Živković, I; Babkevich, P; Rønnow, H M

2018-04-01

We present a compact nuclear magnetic resonance (NMR) probe which is compatible with a magnet of a commercial superconducting quantum interference device magnetometer and demonstrate its application to the study of a quantum magnet. We employ trimmer chip capacitors to construct an NMR tank circuit for low temperature measurements. Using a magnetic insulator MoOPO 4 with S = 1/2 (Mo 5+ ) as an example, we show that the T-dependence of the circuit is weak enough to allow the ligand-ion NMR study of magnetic systems. Our 31 P NMR results are compatible with previous bulk susceptibility and neutron scattering experiments and furthermore reveal unconventional spin dynamics.

Channel electron multiplier compatibility with Viton and Apiezon-L vacuum grease

NASA Astrophysics Data System (ADS)

McComas, D. J.; Baldonado, J. R.; Bame, S. J.; Barraclough, B. L.

1987-12-01

Clean Viton and Viton coated with Apiezon-L vacuum grease were tested for their noncontaminating compatibility with channel electron multipliers (CEMs). The test setup and procedure were the same as those used previously in conjunction with CEM compatibility tests of certain epoxies, solder, and fluorocarbon polymer materials useful for construction of spaceflight sensors. While some CEM gain degradation was noted during exposure to Viton and Apiezon-L, the present tests indicate that, at least over instrument lifetimes of about 2 x 10 to the 12th counts, these materials should be suitable for (1) preflight space sensor testing systems, (2) hermetic seals for CEM-based space sensors, and (3) terrestrial CEM-based instrumentation.

Note: Commercial SQUID magnetometer-compatible NMR probe and its application for studying a quantum magnet

NASA Astrophysics Data System (ADS)

Vennemann, T.; Jeong, M.; Yoon, D.; Magrez, A.; Berger, H.; Yang, L.; Živković, I.; Babkevich, P.; Rønnow, H. M.

2018-04-01

We present a compact nuclear magnetic resonance (NMR) probe which is compatible with a magnet of a commercial superconducting quantum interference device magnetometer and demonstrate its application to the study of a quantum magnet. We employ trimmer chip capacitors to construct an NMR tank circuit for low temperature measurements. Using a magnetic insulator MoOPO4 with S = 1/2 (Mo5+) as an example, we show that the T-dependence of the circuit is weak enough to allow the ligand-ion NMR study of magnetic systems. Our 31P NMR results are compatible with previous bulk susceptibility and neutron scattering experiments and furthermore reveal unconventional spin dynamics.

High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair.

PubMed

Seekhao, Nuttiiya; Shung, Caroline; JaJa, Joseph; Mongeau, Luc; Li-Jessen, Nicole Y K

2018-01-01

Fast and accurate computational biology models offer the prospect of accelerating the development of personalized medicine. A tool capable of estimating treatment success can help prevent unnecessary and costly treatments and potential harmful side effects. A novel high-performance Agent-Based Model (ABM) was adopted to simulate and visualize multi-scale complex biological processes arising in vocal fold inflammation and repair. The computational scheme was designed to organize the 3D ABM sub-tasks to fully utilize the resources available on current heterogeneous platforms consisting of multi-core CPUs and many-core GPUs. Subtasks are further parallelized and convolution-based diffusion is used to enhance the performance of the ABM simulation. The scheme was implemented using a client-server protocol allowing the results of each iteration to be analyzed and visualized on the server (i.e., in-situ ) while the simulation is running on the same server. The resulting simulation and visualization software enables users to interact with and steer the course of the simulation in real-time as needed. This high-resolution 3D ABM framework was used for a case study of surgical vocal fold injury and repair. The new framework is capable of completing the simulation, visualization and remote result delivery in under 7 s per iteration, where each iteration of the simulation represents 30 min in the real world. The case study model was simulated at the physiological scale of a human vocal fold. This simulation tracks 17 million biological cells as well as a total of 1.7 billion signaling chemical and structural protein data points. The visualization component processes and renders all simulated biological cells and 154 million signaling chemical data points. The proposed high-performance 3D ABM was verified through comparisons with empirical vocal fold data. Representative trends of biomarker predictions in surgically injured vocal folds were observed.

High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair

PubMed Central

Seekhao, Nuttiiya; Shung, Caroline; JaJa, Joseph; Mongeau, Luc; Li-Jessen, Nicole Y. K.

2018-01-01

Fast and accurate computational biology models offer the prospect of accelerating the development of personalized medicine. A tool capable of estimating treatment success can help prevent unnecessary and costly treatments and potential harmful side effects. A novel high-performance Agent-Based Model (ABM) was adopted to simulate and visualize multi-scale complex biological processes arising in vocal fold inflammation and repair. The computational scheme was designed to organize the 3D ABM sub-tasks to fully utilize the resources available on current heterogeneous platforms consisting of multi-core CPUs and many-core GPUs. Subtasks are further parallelized and convolution-based diffusion is used to enhance the performance of the ABM simulation. The scheme was implemented using a client-server protocol allowing the results of each iteration to be analyzed and visualized on the server (i.e., in-situ) while the simulation is running on the same server. The resulting simulation and visualization software enables users to interact with and steer the course of the simulation in real-time as needed. This high-resolution 3D ABM framework was used for a case study of surgical vocal fold injury and repair. The new framework is capable of completing the simulation, visualization and remote result delivery in under 7 s per iteration, where each iteration of the simulation represents 30 min in the real world. The case study model was simulated at the physiological scale of a human vocal fold. This simulation tracks 17 million biological cells as well as a total of 1.7 billion signaling chemical and structural protein data points. The visualization component processes and renders all simulated biological cells and 154 million signaling chemical data points. The proposed high-performance 3D ABM was verified through comparisons with empirical vocal fold data. Representative trends of biomarker predictions in surgically injured vocal folds were observed. PMID:29706894

Military Handbook. Grounding, Bonding, and Shielding for Electronic Equipments and Facilities. Volume 2. Applications

DTIC Science & Technology

1987-12-29

EMC, San Francisco CA, 16-18 July 1974, 76-84. 1-13. E. R. Uhlig, "Developmnent of Criteria for Protection ef NIKE -X Power Plant and Facilities...Interference Reduction and Electronic Compatibility, Armour Research Foundation of Illinois Institute of Technology (now IITRI), Chicago IL, October...Measuring Systems Susceptibility," Proceedings of the Eighth Tri-Service Conference on Electromagnetic Compatibility, Armour Research Foundation of

[Automatic Extraction and Analysis of Dosimetry Data in Radiotherapy Plans].

PubMed

Song, Wei; Zhao, Di; Lu, Hong; Zhang, Biyun; Ma, Jun; Yu, Dahai

To improve the efficiency and accuracy of extraction and analysis of dosimetry data in radiotherapy plans for a batch of patients. With the interface function provided in Matlab platform, a program was written to extract the dosimetry data exported from treatment planning system in DICOM RT format and exported the dose-volume data to an Excel file with the SPSS compatible format. This method was compared with manual operation for 14 gastric carcinoma patients to validate the efficiency and accuracy. The output Excel data were compatible with SPSS in format, the dosimetry data error for PTV dose interval of 90%-98%, PTV dose interval of 99%-106% and all OARs were -3.48E-5 ± 3.01E-5, -1.11E-3 ± 7.68E-4, -7.85E-5 ± 9.91E-5 respectively. Compared with manual operation, the time required was reduced from 5.3 h to 0.19 h and input error was reduced from 0.002 to 0. The automatic extraction of dosimetry data in DICOM RT format for batch patients, the SPSS compatible data exportation, quick analysis were achieved in this paper. The efficiency of clinical researches based on dosimetry data analysis of large number of patients will be improved with this methods.

Timeline, Proprietary Data, and Next Steps

DOT National Transportation Integrated Search

2014-09-18

Near Term Schedule (6 Months) [1/2]. September 18, 2014 - GPS Adjacent Band Compatibility Workshop. September/October, 2014 - Possibility of establishing a GPS Adjacent Band Working Group (GABWG). October, 2014 - Schedule checkin's with manufactur...

Environmental Assessment, Minuteman III and Peacekeeper Silo Elimination, Malmstrom AFB, Montana; F. E. Warren AFB, Wyoming; and Vandenberg AFB, California

DTIC Science & Technology

2013-05-01

identified in the EA and referenced in this FONSI, will not have a significant effect on human health or the natural environment; therefore, an... EFFECTS .......................................... 4-54 4.12 COMPATIBILITY OF THE PROPOSED ACTION WITH OBJECTIVES OF FEDERAL, STATE, REGIONAL, AND...HICS Hardened Intersite Cable System HMERP Hazardous Materials Emergency Response Plan HSR Historic Structures Report HVAC heating, ventilation , and

Attention theory and training research

NASA Technical Reports Server (NTRS)

Connelly, James G., Jr.; Wickens, Christopher D.; Lintern, Gavan; Harwood, Kelly

1987-01-01

This study used elements of attention theory as a methodological basis to decompose a complex training task in order to improve training efficiency. The complex task was a microcomputer flight simulation where subjects were required to control the stability of their own helicopter while acquiring and engaging enemy helicopers in a threat enviroment. Subjects were divided into whole-task, part-task, and part/open loop adaptive task groups in a transfer of training paradigm. The effect of reducing mental workload at the early stages of learning was examined with respect to the degree that subordinate elements of the complex task could be automated through practice of consistent, learnable stimulus-response relationships. Results revealed trends suggesting the benefit of isolating consistently mapped sub-tasks for part-task training and the presence of a time-sharing skill over and above the skill required for the separate subtasks.

Unique Genomic Alterations in Prostate Cancers in African American Men

DTIC Science & Technology

2015-12-01

with MNX1 mRNA in AA PCa by Pearson Product Moment. Correlation coefficient and p-value are shown. 13 Subtask 6: Validation of key gene...1 SF 298……………………………………………………………………………..……2 Table of Contents…………………………………………………………..…….... 3 Introduction ...

ROSCOE Manual, Volume 14A-1 - Ambient Atmosphere (Major and Minor Neutral Species and Ionosphere).

DTIC Science & Technology

1979-06-30

height EDDSCH 100 - 300 Parabola, determined by data-point values EBOTD and EF2MXD at altitudes HEBOTD and HF2MXD and vertical slope at altitude HF2MXD...Ionosphere) c Science Applications, Inc. P.O. Box 2351 La Jolla, California 92038 30 June 1979 Final Report for Period 1 January 1976-30 June 1979...ORGANIZATION NAME AND ADDRESS 10 PROGRAM ELEMENT. PROJECT. TASK Science Applications, Inc. V/ AREA 6 WORK U NIT NUMBERS P.O. Box 2351 Subtask S99QAXHCO62-37 La

Geologic setting, petrophysical characteristics, and regional heterogeneity patterns of the Smackover in southwest Alabama. Draft topical report on Subtasks 2 and 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kopaska-Merkel, D.C.; Mann, S.D.; Tew, B.H.

1992-06-01

This is the draft topical report on Subtasks 2 and 3 of DOE contract number DE-FG22-89BC14425, entitled ``Establishment of an oil and gas database for increased recovery and characterization of oil and gas carbonate reservoir heterogeneity.`` This volume constitutes the final report on Subtask 3, which had as its primary goal the geological modeling of reservoir heterogeneity in Smackover reservoirs of southwest Alabama. This goal was interpreted to include a thorough analysis of Smackover reservoirs, which was required for an understanding of Smackover reservoir heterogeneity. This report is divided into six sections (including this brief introduction). Section two, entitled ``Geologicmore » setting,`` presents a concise summary of Jurassic paleogeography, structural setting, and stratigraphy in southwest Alabama. This section also includes a brief review of sedimentologic characteristics and stratigraphic framework of the Smackover, and a summary of the diagenetic processes that strongly affected Smackover reservoirs in Alabama. Section three, entitled ``Analytical methods,`` summarizes all nonroutine aspects of the analytical procedures used in this project. The major topics are thin-section description, analysis of commercial porosity and permeability data, capillary-pressure analysis, and field characterization. ``Smackover reservoir characteristics`` are described in section four, which begins with a general summary of the petrographic characteristics of porous and permeable Smackover strata. This is followed by a more-detailed petrophysical description of Smackover reservoirs.« less

PHARMACEUTICALS IN THE ENVIRONMENT: OVERVIEW ...

EPA Pesticide Factsheets

Pharmaceuticals and personal care products (PPCPs) comprise a large and diverse array of unregulated pollutants that can occur in the environment from the combined activities and actions of multitudes of individuals as well as from veterinary and agricultural use (http://epa.gov/nerlesd1/chemistry/pharma/images/drawing.pdf). Concerted research that began in Europe about two decades ago, and in the u.s. in the late 1990s, has begun escalating in the last few years. Investigation that was originally limited to studying the sources, origins, and occurrence of PPCPs primarily in waters has now expanded to encompass occurrence in other matrices and to consider the complexities involved with the range of unanticipated and subtle effects that might occur from low-dose. chronic exposure of non-target organisms. Risk management options designed around the principles of pollution prevention and environmental stewardship are also under discussion in the healthcare community. This paper will focus on the efforts being coordinated by the U.S. Environmental Protection Agency, much of which is captured on the PPCPs web site: http://epa.gov/nerlesd1/chemistry/pharma/. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support of this Task and more in-depth co

Acoustic and Laser Doppler Anemometer Results for Confluent, 22-Lobed, and Unique-Lobed Mixer Exhaust Systems for Subsonic Jet Noise Reduction

NASA Technical Reports Server (NTRS)

Salikuddin, M.; Martens, S.; Shin, H.; Majjigi, R. K.; Krejsa, Gene (Technical Monitor)

2002-01-01

The objective of this task was to develop a design methodology and noise reduction concepts for high bypass exhaust systems which could be applied to both existing production and new advanced engine designs. Special emphasis was given to engine cycles with bypass ratios in the range of 4:1 to 7:1, where jet mixing noise was a primary noise source at full power takeoff conditions. The goal of this effort was to develop the design methodology for mixed-flow exhaust systems and other novel noise reduction concepts that would yield 3 EPNdB noise reduction relative to 1992 baseline technology. Two multi-lobed mixers, a 22-lobed axisymmetric and a 21-lobed with a unique lobe, were designed. These mixers along with a confluent mixer were tested with several fan nozzles of different lengths with and without acoustic treatment in GEAE's Cell 41 under the current subtask (Subtask C). In addition to the acoustic and LDA tests for the model mixer exhaust systems, a semi-empirical noise prediction method for mixer exhaust system is developed. Effort was also made to implement flowfield data for noise prediction by utilizing MGB code. In general, this study established an aero and acoustic diagnostic database to calibrate and refine current aero and acoustic prediction tools.

Cross-Layer Design for Robust and Scalable Video Transmission in Dynamic Wireless Environment

DTIC Science & Technology

2011-02-01

code rate convolutional codes or prioritized Rate - Compatible Punctured ...34New rate - compatible punctured convolutional codes for Viterbi decoding," IEEE Trans. Communications, Volume 42, Issue 12, pp. 3073-3079, Dec...Quality of service RCPC Rate - compatible and punctured convolutional codes SNR Signal to noise

Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria.

PubMed

Herrou, Julien; Willett, Jonathan W; Czyż, Daniel M; Babnigg, Gyorgy; Kim, Youngchang; Crosson, Sean

2017-03-01

Brucella abortus σ E1 is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon, bab1_0223-bab1_0226 , is among the most highly activated gene sets in the σ E1 regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription of yehZYXW is activated by the general stress sigma factor σ S in Enterobacteriaceae , which suggests a functional role for this transport system in bacterial stress response across the classes Alphaproteobacteria and Gammaproteobacteria We present evidence that B. abortus YehZYXW does not function as an importer of known compatible solutes under physiological conditions and does not contribute to the virulence defect of a σ E1 -null strain. The sole in vitro phenotype associated with genetic disruption of this putative transport system is reduced growth in the presence of high Li + ion concentrations. A crystal structure of B. abortus YehZ revealed a class II periplasmic binding protein fold with significant structural homology to Archaeoglobus fulgidus ProX, which binds glycine betaine. However, the structure of the YehZ ligand-binding pocket is incompatible with high-affinity binding to glycine betaine. This is consistent with weak measured binding of YehZ to glycine betaine and related compatible solutes. We conclude that YehZYXW is a conserved, stress-regulated transport system that is phylogenetically and functionally distinct from quaternary ammonium-compatible solute importers. IMPORTANCE Brucella abortus σ E1 regulates transcription in response to stressors encountered in its mammalian host and is necessary for maintenance of chronic infection in a mouse model. The functions of the majority of genes regulated by σ E1 remain undefined. We present a functional/structural analysis of a conserved putative membrane transport system (YehZYXW) whose expression is strongly activated by σ E1 Though annotated as a quaternary ammonium osmolyte uptake system, experimental physiological studies and measured ligand-binding properties of the periplasmic binding protein (PBP), YehZ, are inconsistent with this function. A crystal structure of B. abortus YehZ provides molecular insight into differences between bona fide quaternary ammonium osmolyte importers and YehZ-related proteins, which form a distinct phylogenetic and functional group of PBPs. Copyright © 2017 American Society for Microbiology.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herrou, Julien; Willett, Jonathan W.; Czyż, Daniel M.

ABSTRACT Brucella abortusσ E1is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon,bab1_0223-bab1_0226, is among the most highly activated gene sets in the σ E1regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription ofyehZYXWis activated by the general stress sigma factor σ SinEnterobacteriaceae, which suggests a functional role for this transport systemmore » in bacterial stress response across the classesAlphaproteobacteriaandGammaproteobacteria. We present evidence thatB. abortusYehZYXW does not function as an importer of known compatible solutes under physiological conditions and does not contribute to the virulence defect of a σ E1-null strain. The solein vitrophenotype associated with genetic disruption of this putative transport system is reduced growth in the presence of high Li +ion concentrations. A crystal structure ofB. abortusYehZ revealed a class II periplasmic binding protein fold with significant structural homology toArchaeoglobus fulgidusProX, which binds glycine betaine. However, the structure of the YehZ ligand-binding pocket is incompatible with high-affinity binding to glycine betaine. This is consistent with weak measured binding of YehZ to glycine betaine and related compatible solutes. We conclude that YehZYXW is a conserved, stress-regulated transport system that is phylogenetically and functionally distinct from quaternary ammonium-compatible solute importers. IMPORTANCEBrucella abortusσ E1regulates transcription in response to stressors encountered in its mammalian host and is necessary for maintenance of chronic infection in a mouse model. The functions of the majority of genes regulated by σ E1remain undefined. We present a functional/structural analysis of a conserved putative membrane transport system (YehZYXW) whose expression is strongly activated by σ E1. Though annotated as a quaternary ammonium osmolyte uptake system, experimental physiological studies and measured ligand-binding properties of the periplasmic binding protein (PBP), YehZ, are inconsistent with this function. A crystal structure ofB. abortusYehZ provides molecular insight into differences between bona fide quaternary ammonium osmolyte importers and YehZ-related proteins, which form a distinct phylogenetic and functional group of PBPs.« less

Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herrou, Julien; Willett, Jonathan W.; Czyż, Daniel M.

ABSTRACT Brucella abortusσ E1is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon,bab1_0223-bab1_0226, is among the most highly activated gene sets in the σ E1regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription ofyehZYXWis activated by the general stress sigma factor σ SinEnterobacteriaceae, which suggests a functional role for this transport systemmore » in bacterial stress response across the classesAlphaproteobacteriaandGammaproteobacteria. We present evidence thatB. abortusYehZYXW does not function as an importer of known compatible solutes under physiological conditions and does not contribute to the virulence defect of a σ E1-null strain. The solein vitrophenotype associated with genetic disruption of this putative transport system is reduced growth in the presence of high Li +ion concentrations. A crystal structure ofB. abortusYehZ revealed a class II periplasmic binding protein fold with significant structural homology toArchaeoglobus fulgidusProX, which binds glycine betaine. However, the structure of the YehZ ligand-binding pocket is incompatible with high-affinity binding to glycine betaine. This is consistent with weak measured binding of YehZ to glycine betaine and related compatible solutes. We conclude that YehZYXW is a conserved, stress-regulated transport system that is phylogenetically and functionally distinct from quaternary ammonium-compatible solute importers. IMPORTANCEBrucella abortusσ E1regulates transcription in response to stressors encountered in its mammalian host and is necessary for maintenance of chronic infection in a mouse model. The functions of the majority of genes regulated by σ E1remain undefined. We present a functional/structural analysis of a conserved putative membrane transport system (YehZYXW) whose expression is strongly activated by σ E1. Though annotated as a quaternary ammonium osmolyte uptake system, experimental physiological studies and measured ligand-binding properties of the periplasmic binding protein (PBP), YehZ, are inconsistent with this function. A crystal structure ofB. abortusYehZ provides molecular insight into differences between bona fide quaternary ammonium osmolyte importers and YehZ-related proteins, which form a distinct phylogenetic and functional group of PBPs.« less

The Influence of Aconitum carmichaelii Debx. on the Pharmacokinetic Characteristics of Main Components in Rheum palmatum L.

PubMed

Li, Yun-xia; Gong, Xiao-hong; Li, Yan; Zhang, Ruo-qi; Yuan, An; Zhao, Meng-jie; Zeng, Dai-wen; Peng, Cheng

2015-08-01

Rhei Radix et Rhizoma was one of the commonly used traditional Chinese medicines, and the compatibility of Rhei Radix et Rhizoma and Aconiti Lateralis Radix Praeparata was the basic herb pair applied in many Chinese traditional prescription. Rhubarb anthraquinones were the main bioactive materials of Rhei Radix et Rhizoma. To elucidate the compatibility of Rhei Radix et Rhizoma and Aconiti Lateralis Radix Praeparata, the pharmacokinetics of rhubarb anthraquinones as the main marker constituents were investigated. In the present study, pharmacokinetic differences of rhubarb anthraquinones were detected after oral administration of extract of Rheum palmatum L. and compatibility with Aconitum carmichaelii Debx. After oral administration, no difference of peak time can be found for anthraquinones between rhubarb group and compatibility group. But Cmax and area under the curve of aloe-emodin, emodin and chrysophanol in compatibility group were significantly higher than that in rhubarb group. Although the Cmax of rhein in compatibility group was much lower than that in rhubarb group, the area under the curve value was similar in two groups. The clearance and t1/2 of rhubarb anthraquinone were also changed after compatibility. The change of pharmacokinetics characteristics of rhubarb anthraquinone after compatibility may be caused by the drug-drug interaction medicated by chemical reaction and cytochromes P450. Copyright © 2015 John Wiley & Sons, Ltd.

Low-voltage, high-extinction-ratio, Mach-Zehnder silicon optical modulator for CMOS-compatible integration.

PubMed

Ding, Jianfeng; Chen, Hongtao; Yang, Lin; Zhang, Lei; Ji, Ruiqiang; Tian, Yonghui; Zhu, Weiwei; Lu, Yangyang; Zhou, Ping; Min, Rui

2012-01-30

We demonstrate a carrier-depletion Mach-Zehnder silicon optical modulator, which is compatible with CMOS fabrication process and works well at a low driving voltage. This is achieved by the optimization of the coplanar waveguide electrode to reduce the electrical signal transmission loss. At the same time, the velocity and impedance matching are both considered. The 12.5 Gbit/s data transmission experiment of the fabricated device with a 2-mm-long phase shifter is performed. The driving voltages with the swing amplitudes of 1 V and 2 V and the reverse bias voltages of 0.5 V and 0.8 V are applied to the device, respectively. The corresponding extinction ratios are 7.67 and 12.79 dB.

Composing problem solvers for simulation experimentation: a case study on steady state estimation.

PubMed

Leye, Stefan; Ewald, Roland; Uhrmacher, Adelinde M

2014-01-01

Simulation experiments involve various sub-tasks, e.g., parameter optimization, simulation execution, or output data analysis. Many algorithms can be applied to such tasks, but their performance depends on the given problem. Steady state estimation in systems biology is a typical example for this: several estimators have been proposed, each with its own (dis-)advantages. Experimenters, therefore, must choose from the available options, even though they may not be aware of the consequences. To support those users, we propose a general scheme to aggregate such algorithms to so-called synthetic problem solvers, which exploit algorithm differences to improve overall performance. Our approach subsumes various aggregation mechanisms, supports automatic configuration from training data (e.g., via ensemble learning or portfolio selection), and extends the plugin system of the open source modeling and simulation framework James II. We show the benefits of our approach by applying it to steady state estimation for cell-biological models.

Ad Hoc Information Extraction for Clinical Data Warehouses.

PubMed

Dietrich, Georg; Krebs, Jonathan; Fette, Georg; Ertl, Maximilian; Kaspar, Mathias; Störk, Stefan; Puppe, Frank

2018-05-01

Clinical Data Warehouses (CDW) reuse Electronic health records (EHR) to make their data retrievable for research purposes or patient recruitment for clinical trials. However, much information are hidden in unstructured data like discharge letters. They can be preprocessed and converted to structured data via information extraction (IE), which is unfortunately a laborious task and therefore usually not available for most of the text data in CDW. The goal of our work is to provide an ad hoc IE service that allows users to query text data ad hoc in a manner similar to querying structured data in a CDW. While search engines just return text snippets, our systems also returns frequencies (e.g. how many patients exist with "heart failure" including textual synonyms or how many patients have an LVEF < 45) based on the content of discharge letters or textual reports for special investigations like heart echo. Three subtasks are addressed: (1) To recognize and to exclude negations and their scopes, (2) to extract concepts, i.e. Boolean values and (3) to extract numerical values. We implemented an extended version of the NegEx-algorithm for German texts that detects negations and determines their scope. Furthermore, our document oriented CDW PaDaWaN was extended with query functions, e.g. context sensitive queries and regex queries, and an extraction mode for computing the frequencies for Boolean and numerical values. Evaluations in chest X-ray reports and in discharge letters showed high F1-scores for the three subtasks: Detection of negated concepts in chest X-ray reports with an F1-score of 0.99 and in discharge letters with 0.97; of Boolean values in chest X-ray reports about 0.99, and of numerical values in chest X-ray reports and discharge letters also around 0.99 with the exception of the concept age. The advantages of an ad hoc IE over a standard IE are the low development effort (just entering the concept with its variants), the promptness of the results and the adaptability by the user to his or her particular question. Disadvantage are usually lower accuracy and confidence.This ad hoc information extraction approach is novel and exceeds existing systems: Roogle [1] extracts predefined concepts from texts at preprocessing and makes them retrievable at runtime. Dr. Warehouse [2] applies negation detection and indexes the produced subtexts which include affirmed findings. Our approach combines negation detection and the extraction of concepts. But the extraction does not take place during preprocessing, but at runtime. That provides an ad hoc, dynamic, interactive and adjustable information extraction of random concepts and even their values on the fly at runtime. We developed an ad hoc information extraction query feature for Boolean and numerical values within a CDW with high recall and precision based on a pipeline that detects and removes negations and their scope in clinical texts. Schattauer GmbH.

Design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals

NASA Astrophysics Data System (ADS)

Tsui, Benjamin M. W.; Hugg, James W.; Xu, Jingyan; Chen, Si; Meier, Dirk; Edelstein, William; El-Sharkawy, Abdel; Wagenaar, Douglas J.; Patt, Bradley E.

2011-03-01

We describe a continuing design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals. A first generation prototype SPECT system was designed and constructed to fit inside a MRI system with a gradient bore inner diameter of 12 cm. It consists of 3 angularly offset rings of 8 detectors (1"x1", 16x16 pixels MR-compatible solid-state CZT). A matching 24-pinhole collimator sleeve, made of a tungsten-compound, provides projections from a common FOV of ~25 mm. A birdcage RF coil for MRI data acquisition surrounds the collimator. The SPECT system was tested inside a clinical 3T MRI system. Minimal interference was observed on the simultaneously acquired SPECT and MR images. We developed a sparse-view image reconstruction method based on accurate modeling of the point response function (PRF) of each of the 24 pinholes to provide artifact-free SPECT images. The stationary SPECT system provides relatively low resolution of 3-5 mm but high geometric efficiency of 0.5- 1.2% for fast dynamic acquisition, demonstrated in a SPECT renal kinetics study using Tc-99m DTPA. Based on these results, a second generation prototype MR-compatible SPECT system with an outer diameter of 20 cm that fits inside a mid-sized preclinical MRI system is being developed. It consists of 5 rings of 19 CZT detectors. The larger ring diameter allows the use of optimized multi-pinhole collimator designs, such as high system resolution up to ~1 mm, high geometric efficiency, or lower system resolution without collimator rotation. The anticipated performance of the new system is supported by simulation data.

Development of ODS FeCrAl for compatibility in fusion and fission energy applications

DOE PAGES

Pint, Bruce A.; Dryepondt, Sebastien N.; Unocic, Kinga A.; ...

2014-11-15

In this paper, oxide dispersion strengthened (ODS) FeCrAl alloys with 12–15% Cr are being evaluated for improved compatibility with Pb-Li for a fusion energy application and with high temperature steam for a more accident-tolerant light water reactor fuel cladding application. A 12% Cr content alloy showed low mass losses in static Pb-Li at 700°C, where a LiAlO 2 surface oxide formed and inhibited dissolution into the liquid metal. All the evaluated compositions formed a protective scale in steam at 1200°C, which is not possible with ODS FeCr alloys. However, most of the compositions were not protective at 1400°C, which ismore » a general and somewhat surprising problem with ODS FeCrAl alloys that is still being studied. More work is needed to optimize the alloy composition, microstructure and oxide dispersion, but initial promising tensile and creep results have been obtained with mixed oxide additions, i.e. Y 2O 3 with ZrO 2, HfO 2 or TiO 2.« less

Randomized, Observer-blind, Split-face Compatibility Study with Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.75% gel and Facial Foundation Makeup

PubMed Central

Pillai, Radhakrishnan

2015-01-01

Background: Cosmetic compatibility in the treatment of acne is an important issue significantly impacting quality of life, but often overlooked, as dermatologists commonly recommended avoidance of cosmetic foundations when treating adult female patients. Fixed combinations of clindamycin/benzoyl peroxide are widely used in the treatment of acne, but little is known about the impact of their concomitant use with facial foundation. Objective: To assess the compatibility of clindamycin phosphate 1. 2%/benzoyl peroxide 3. 75% gel with foundation makeup for up to six hours after application. Methods: Twenty-nine female subjects applied makeup to their face after randomly applying clindamycin phosphate 1. 2%/benzoyl peroxide 3. 75% gel to one side of the face. Investigator and subject self- assessment included facial skin attributes, facial tolerability, and cosmetic compatibility post-application and at Hour 6; as well as cutaneous tolerability. Results: No statistical difference was noted between the treated and untreated side of the face in terms of coverage, blotchiness, appearance, skin tone, or visual smoothness. Tolerability was excellent, with no erythema, edema, dryness, and peeling post-makeup application. For both the treated and untreated side, there was a slight lack of improvement in cosmetic appearance six hours post-makeup application. Conclusion: Clindamycin/benzoyl peroxide 3. 75% gel was shown to have excellent cosmetic compatibility with facial foundation. PMID:26430488

Randomized, Observer-blind, Split-face Compatibility Study with Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.75% gel and Facial Foundation Makeup.

PubMed

Bhatia, Neal; Pillai, Radhakrishnan

2015-09-01

Cosmetic compatibility in the treatment of acne is an important issue significantly impacting quality of life, but often overlooked, as dermatologists commonly recommended avoidance of cosmetic foundations when treating adult female patients. Fixed combinations of clindamycin/benzoyl peroxide are widely used in the treatment of acne, but little is known about the impact of their concomitant use with facial foundation. To assess the compatibility of clindamycin phosphate 1. 2%/benzoyl peroxide 3. 75% gel with foundation makeup for up to six hours after application. Twenty-nine female subjects applied makeup to their face after randomly applying clindamycin phosphate 1. 2%/benzoyl peroxide 3. 75% gel to one side of the face. Investigator and subject self- assessment included facial skin attributes, facial tolerability, and cosmetic compatibility post-application and at Hour 6; as well as cutaneous tolerability. No statistical difference was noted between the treated and untreated side of the face in terms of coverage, blotchiness, appearance, skin tone, or visual smoothness. Tolerability was excellent, with no erythema, edema, dryness, and peeling post-makeup application. For both the treated and untreated side, there was a slight lack of improvement in cosmetic appearance six hours post-makeup application. Clindamycin/benzoyl peroxide 3. 75% gel was shown to have excellent cosmetic compatibility with facial foundation.

Could We Make Diverse Learning Materials Compatible with E-Readers Used in Classroom Learning Settings?

ERIC Educational Resources Information Center

Young, Shelley Shwu-Ching; Lin, Wei-Lin

2012-01-01

This study explores how to make diverse learning/instructional materials compatible with e-readers when the instructor pioneered to adopt e-readers into a course of the graduate level. What problems did the instructor encounter when she used the e-readers as a major tool to deliver learning contents, such as the process of converting the…

A novel BRCA-1 mutation in Arab kindred from east Jerusalem with breast and ovarian cancer

PubMed Central

Kadouri, Luna; Bercovich, Dani; Elimelech, Arava; Lerer, Israela; Sagi, Michal; Glusman, Gila; Shochat, Chen; Korem, Sigal; Hamburger, Tamar; Nissan, Aviram; Abu-Halaf, Nahil; Badrriyah, Muhmud; Abeliovich, Dvorah; Peretz, Tamar

2007-01-01

Background The incidence of breast cancer (BC) in Arab women is lower compared to the incidence in the Jewish population in Israel; still, it is the most common malignancy among Arab women. There is a steep rise in breast cancer incidence in the Arab population in Israel over the last 10 years that can be attributed to life style changes. But, the younger age of BC onset in Arab women compared with that of the Jewish population is suggestive of a genetic component in BC occurrence in that population. Methods We studied the family history of 31 women of Palestinian Arab (PA) origin affected with breast (n = 28), ovarian (n = 3) cancer. We used denaturing high performance liquid chromatography (DHPLC) to screen for mutations of BRCA1/2 in 4 women with a personal and family history highly suggestive of genetic predisposition. Results A novel BRCA1 mutation, E1373X in exon 12, was found in a patient affected with ovarian cancer. Four of her family members, 3 BC patients and a healthy individual were consequently also found to carry this mutation. Of the other 27 patients, which were screened for this specific mutation none was found to carry it. Conclusion We found a novel BRCA1 mutation in a family of PA origin with a history highly compatible with BRCA1 phenotype. This mutation was not found in additional 30 PA women affected with BC or OC. Therefore full BRCA1/2 screening should be offered to patients with characteristic family history. The significance of the novel BRCA1 mutation we identified should be studied in larger population. However, it is likely that the E1373X mutation is not a founder frequent mutation in the PA population. PMID:17233897

Properties of an R Factor from Pseudomonas aeruginosa

PubMed Central

Datta, Naomi; Hedges, R. W.; Shaw, Elizabeth J.; Sykes, R. B.; Richmond, M. H.

1971-01-01

An R factor from Pseudomonas aeruginosa, which confers resistance to penicillins, kanamycin, and tetracycline, was studied in Escherichia coli K-12. The R factor could coexist with F-like or I-like plasmids and therefore constituted a novel compatibility group. The R factor was transferable from E. coli to bacterial genera outside the Enterobacteriaceae (Pseudomonas and members of the Rhizobiaceae) to which transfer of F-like and I-like plasmids could not be demonstrated. PMID:4945193

Production of high-density highly-ionized helicon plasmas in the ProtoMPEX

NASA Astrophysics Data System (ADS)

Caneses, J. F.; Kafle, N.; Showers, M.; Goulding, R. H.; Biewer, T. M.; Caughman, J. B. O.; Bigelow, T.; Rapp, J.

2017-10-01

High-density (2-6e19 m-3) Deuterium helicon plasmas in the ProtoMPEX have been produced that successfully use differential pumping to produce neutral gas pressures suitable for testing the RF electron and ion heating concepts. To minimize collisional losses when heating electrons and ions, plasmas with very low neutral gas content (<< 0.1 Pa) in the heating sections are required. This requirement is typically not compatible with the neutral gas pressures (1-2 Pa) commonly used in high-density light-ion helicon sources. By using skimmers, a suitable gas injection scheme and long duration discharges (>0.3 s), high-density plasmas with very low neutral gas pressures (<< 0.1 Pa) in the RF heating sections have been produced. Measurements indicate the presence of a highly-ionized plasma column and that discharges lasting at least 0.3 s are required to significantly reduce the neutral gas pressure in the RF heating sections to levels suitable for investigating electron/ion RF heating concepts in this linear configuration. This work was supported by the US. D.O.E. contract DE-AC05-00OR22725.

Perceived Compatibility and the Adoption of B2C E-Commerce by Non-buyers

NASA Astrophysics Data System (ADS)

Hernández-García, Ángel; Iglesias-Pradas, Santiago; Chaparro-Peláez, Julián; Pascual-Miguel, Félix

The purpose of this article is to study the factors which affect the intention to buy online for users who have never made any prior purchase using the electronic channel, with special focus to the role of perceived compatibility. To do so, an adoption model for e-commerce was proposed on the basis of the Technology Adoption Model (TAM) and the Innovations Diffusion Theory (IDT). In order to validate the model, data gathered amongst Spanish consumers who had no experience using e-commerce, were analyzed using the partial least squares (PLS) method. The results have demonstrated the importance of perceived compatibility as a significant factor to foster non-buyers' adoption of electronic business-to-consumer e-commerce (eB2C).

Long wavelength propagation capacity, version 1.1 (computer diskette)

NASA Astrophysics Data System (ADS)

1994-05-01

File Characteristics: software and data file. (72 files); ASCII character set. Physical Description: 2 computer diskettes; 3 1/2 in.; high density; 1.44 MB. System Requirements: PC compatible; Digital Equipment Corp. VMS; PKZIP (included on diskette). This report describes a revision of the Naval Command, Control and Ocean Surveillance Center RDT&E Division's Long Wavelength Propagation Capability (LWPC). The first version of this capability was a collection of separate FORTRAN programs linked together in operation by a command procedure written in an operating system unique to the Digital Equipment Corporation (Ferguson & Snyder, 1989a, b). A FORTRAN computer program named Long Wavelength Propagation Model (LWPM) was developed to replace the VMS control system (Ferguson & Snyder, 1990; Ferguson, 1990). This was designated version 1 (LWPC-1). This program implemented all the features of the original VMS plus a number of auxiliary programs that provided summaries of the files and graphical displays of the output files. This report describes a revision of the LWPC, designated version 1.1 (LWPC-1.1)

Strategic avionics technology definition studies. Subtask 3-1A3: Electrical Actuation (ELA) Systems Test Facility

NASA Technical Reports Server (NTRS)

Rogers, J. P.; Cureton, K. L.; Olsen, J. R.

1994-01-01

Future aerospace vehicles will require use of the Electrical Actuator systems for flight control elements. This report presents a proposed ELA Test Facility for dynamic evaluation of high power linear Electrical Actuators with primary emphasis on Thrust Vector Control actuators. Details of the mechanical design, power and control systems, and data acquisition capability of the test facility are presented. A test procedure for evaluating the performance of the ELA Test Facility is also included.

Structured Analysis/Design - LSA Task 101, Early Logistic Support Analysis Strategy, Subtask 101.2.1, Develop Early LSA Strategy

DTIC Science & Technology

1990-07-01

replacing "logic diagrams" or "flow charts") to aid in coordinating the functions to be performed by a computer program and its associated Inputs...ADDRESS (City, State, and ZIP Code) 10. SOURCE OF FUNDING NUMBERS PROGRAM PROJECT ITASK IWORK UNIT ELEMENT NO. NO. NO. ACCESSION NO. 11. TITLE...the analysis. Both the logical model and detailed procedures are used to develop the application software programs which will be provided to Government

Using Arrays of Microelectrodes Implanted in Residual Peripheral Nerves to Provide Dexterous Control of, and Modulated Sensory Feedback from, a Hand Prosthesis

DTIC Science & Technology

2017-10-01

potentials or multi-action potential activity from residual peripheral nerve while patient intends movements of amputated hand/arm Subtask 3.1: Mapping of...neural activity (Months 4 – 36) • Patients will be asked to intend a number of individual finger and multiple finger flexion, extension, adduction...intended movements. We will map the different intended movements onto the neural activity recorded on the electrodes of the micro-electrode array

Using Arrays of Microelectrodes Implanted in Residual Peripheral Nerves to Provide Dexterous Control of, and Modulated Sensory Feedback from, a Hand Prosthesis

DTIC Science & Technology

2016-10-01

isolated action potentials or multi-action potential activity from residual peripheral nerve while patient intends movements of amputated hand/arm...Subtask 3.1: Mapping of neural activity (Months 4 – 36) • Patients will be asked to intend a number of individual finger and multiple finger flexion...during these intended movements. We will map the different intended movements onto the neural activity recorded on the electrodes of the micro-electrode

Integrated Reconfigurable Intelligent Systems (IRIS) for Complex Naval Systems

DTIC Science & Technology

2011-02-23

INTRODUCTION 35 2.2 GENERAL MODEL SETUP 36 2.2.1 Co-Simulation Principles 36 2.2.2 Double pendulum : a simple example 38 2.2.3 Description of numerical... pendulum sample problem 45 2.3 DISCUSSION OF APPROACH WITH RESPECT TO PROPOSED SUBTASKS 49 2.4 RESULTS DISCUSSION AND FUTURE WORK 49 TASK 3...Kim and Praehofer 2000]. 2.2.2 Double pendulum : a simple example In order to be able to evaluate co-simulation principles, specifically an

The Role of Adenosine A2BR in Metastatic Melanoma

DTIC Science & Technology

2017-07-01

100% complete. ACURO approval to perform animal studies was obtained July 2016. Specific Aim 1, Subtask 2: 100% complete. Use CRISPR /Cas9 technology...immune cell interactions, the first objective was to use the CRISPR Cas9 system to knock out A2BR expression in melanoma cell lines. Melanoma cell lines...and sgRNA3 to work but sgRNA2 would not be as efficient. We considered commercially available constructs to potentially improve the CRISPR knock

Space Construction Experiment Definition Study (SCEDS), part 1. Volume 2: Study results

NASA Technical Reports Server (NTRS)

1981-01-01

A basic Space Shuttle flight experiment which will provide needed data on the construction of large space systems from the Orbiter was defined. The predicted dynamic behavior of a representative large structure, on-orbit construction operations, and Orbiter control during and after construction were studied. Evolutionary or supplemental flight experiments for the development or augmentation of a basic flight experiment were identified and defined. The study was divided into six major tasks with appropriate sub-tasks noted.

Evaluation and Analysis of SEASAT-A Scanning Multichannel Microwave Radiometer (SSMR) Antenna Pattern Correction (APC) Algorithm. Sub-task 4: Interim Mode T Sub B Versus Cross and Nominal Mode T Sub B

NASA Technical Reports Server (NTRS)

Kitzis, J. L.; Kitzis, S. N.

1979-01-01

The brightness temperature data produced by the SMMR Antenna Pattern Correction algorithm are evaluated. The evaluation consists of: (1) a direct comparison of the outputs of the interim, cross, and nominal APC modes; (2) a refinement of the previously determined cos beta estimates; and (3) a comparison of the world brightness temperature (T sub B) map with actual SMMR measurements.

CO2 Capture Project: An Integrated, Collaborative Technology Development Project For CO2 Separation, Capture And Geologic Sequestration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helen Kerr

2002-01-10

This report (which forms part of the requirements of the Statement of Work Task 0, subtask 0.4) records progress towards defining a detailed Work Plan for the CCP 30 days after contract initiation. It describes the studies planned, workscope development and technology provider bid evaluation status at that time. Business sensitive information is provided separately in Appendix 1. Contract negotiations are on hold pending award of patent waiver status to the CCP.

Anatomy-Specific Virtual Reality Simulation in Temporal Bone Dissection: Perceived Utility and Impact on Surgeon Confidence.

PubMed

Locketz, Garrett D; Lui, Justin T; Chan, Sonny; Salisbury, Kenneth; Dort, Joseph C; Youngblood, Patricia; Blevins, Nikolas H

2017-06-01

Objective To evaluate the effect of anatomy-specific virtual reality (VR) surgical rehearsal on surgeon confidence and temporal bone dissection performance. Study Design Prospective pre- and poststudy of a novel virtual surgical rehearsal platform. Setting Academic otolaryngology-head and neck surgery residency training programs. Subjects and Methods Sixteen otolaryngology-head and neck surgery residents from 2 North American training institutions were recruited. Surveys were administered to assess subjects' baseline confidence in performing 12 subtasks of cortical mastoidectomy with facial recess. A cadaver temporal bone was randomly assigned to each subject. Cadaver specimens were scanned with a clinical computed tomography protocol, allowing the creation of anatomy-specific models for use in a VR surgical rehearsal platform. Subjects then rehearsed a virtual mastoidectomy on data sets derived from their specimens. Surgical confidence surveys were administered again. Subjects then dissected assigned cadaver specimens, which were blindly graded with a modified Welling scale. A final survey assessed the perceived utility of rehearsal on dissection performance. Results Of 16 subjects, 14 (87.5%) reported a significant increase in overall confidence after conducting an anatomy-specific VR rehearsal. A significant correlation existed between perceived utility of rehearsal and confidence improvement. The effect of rehearsal on confidence was dependent on trainee experience and the inherent difficulty of the surgical subtask. Postrehearsal confidence correlated strongly with graded dissection performance. Subjects rated anatomy-specific rehearsal as having a moderate to high contribution to their dissection performance. Conclusion Anatomy-specific virtual rehearsal improves surgeon confidence in performing mastoid dissection, dependent on surgeon experience and task difficulty. The subjective confidence gained through rehearsal correlates positively with subsequent objective dissection performance.

Evaluation of Methods for Multidisciplinary Design Optimization (MDO). Part 2

NASA Technical Reports Server (NTRS)

Kodiyalam, Srinivas; Yuan, Charles; Sobieski, Jaroslaw (Technical Monitor)

2000-01-01

A new MDO method, BLISS, and two different variants of the method, BLISS/RS and BLISS/S, have been implemented using iSIGHT's scripting language and evaluated in this report on multidisciplinary problems. All of these methods are based on decomposing a modular system optimization system into several subtasks optimization, that may be executed concurrently, and the system optimization that coordinates the subtasks optimization. The BLISS method and its variants are well suited for exploiting the concurrent processing capabilities in a multiprocessor machine. Several steps, including the local sensitivity analysis, local optimization, response surfaces construction and updates are all ideally suited for concurrent processing. Needless to mention, such algorithms that can effectively exploit the concurrent processing capabilities of the compute servers will be a key requirement for solving large-scale industrial design problems, such as the automotive vehicle problem detailed in Section 3.4.

Allocating time to future tasks: the effect of task segmentation on planning fallacy bias.

PubMed

Forsyth, Darryl K; Burt, Christopher D B

2008-06-01

The scheduling component of the time management process was used as a "paradigm" to investigate the allocation of time to future tasks. In three experiments, we compared task time allocation for a single task with the summed time allocations given for each subtask that made up the single task. In all three, we found that allocated time for a single task was significantly smaller than the summed time allocated to the individual subtasks. We refer to this as the segmentation effect. In Experiment 3, we asked participants to give estimates by placing a mark on a time line, and found that giving time allocations in the form of rounded close approximations probably does not account for the segmentation effect. We discuss the results in relation to the basic processes used to allocate time to future tasks and the means by which planning fallacy bias might be reduced.

Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.

PubMed

Lantos, Paul M; Branda, John A; Boggan, Joel C; Chudgar, Saumil M; Wilson, Elizabeth A; Ruffin, Felicia; Fowler, Vance; Auwaerter, Paul G; Nigrovic, Lise E

2015-11-01

Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical illness, but the significance of positive test results in low-prevalence regions has not been investigated. We reviewed the medical records of patients who tested positive for Lyme disease with standardized 2-tiered serologic testing between 2005 and 2010 at a single hospital system in a region with little endemic Lyme disease. Based on clinical findings, we calculated the positive predictive value of Lyme disease serology. Next, we reviewed the outcome of serologic testing in patients with select clinical syndromes compatible with disseminated Lyme disease (arthritis, cranial neuropathy, or meningitis). During the 6-year study period 4723 patients were tested for Lyme disease, but only 76 (1.6%) had positive results by established laboratory criteria. Among 70 seropositive patients whose medical records were available for review, 12 (17%; 95% confidence interval, 9%-28%) were found to have Lyme disease (6 with documented travel to endemic regions). During the same time period, 297 patients with a clinical illness compatible with disseminated Lyme disease underwent 2-tiered serologic testing. Six of them (2%; 95% confidence interval, 0.7%-4.3%) were seropositive, 3 with documented travel and 1 who had an alternative diagnosis that explained the clinical findings. In this low-prevalence cohort, fewer than 20% of positive Lyme disease tests are obtained from patients with clinically likely Lyme disease. Positive Lyme disease test results may have little diagnostic value in this setting. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Assessment of Energy Removal Impacts on Physical Systems: Hydrodynamic Model Domain Expansion and Refinement, and Online Dissemination of Model Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Zhaoqing; Khangaonkar, Tarang; Wang, Taiping

In this report we describe the 1) the expansion of the PNNL hydrodynamic model domain to include the continental shelf along the coasts of Washington, Oregon, and Vancouver Island; and 2) the approach and progress in developing the online/Internet disseminations of model results and outreach efforts in support of the Puget Sound Operational Forecast System (PS-OPF). Submittal of this report completes the work on Task 2.1.2, Effects of Physical Systems, Subtask 2.1.2.1, Hydrodynamics, for fiscal year 2010 of the Environmental Effects of Marine and Hydrokinetic Energy project.

Effect of Slow Fading and Adaptive Modulation on TCP/UDP Performance of High-Speed Packet Wireless Networks

DTIC Science & Technology

2006-08-25

interleaving schemes defined in 802.11a standard, although only 6 Mbps data rate with BPSK and 1/2 Convolutional coding and puncturing is used in our...16-QAM/64-QAM Convolutional Code K = 7 (64 states) K = 7 (64 states) Coding Rates 1/2, 2/3, 3/4 1/2, 2/3, 3/4 Channel Spacing (MHz) 20 10 Signal...Since 3G systems need to be backward compatible with 2G systems, they are a combination of existing and evolved equipments with data rate up to 2 Mbps

Analysis of the Influence of HLA-A Matching Relative to HLA-B and -DR Matching on Heart Transplant Outcomes

PubMed Central

Ansari, David; Bućin, Dragan; Höglund, Peter; Ohlsson, Mattias; Andersson, Bodil; Nilsson, Johan

2015-01-01

Background There are conflicting reports on the effect of donor-recipient HLA matching on outcomes in heart transplantation. The objective of this study was to investigate the effects of HLA-A matching relative to HLA-B and -DR matching on long-term survival in heart transplantation. Methods A total of 25 583 patients transplanted between 1988 and 2011 were identified from the International Society for Heart and Lung Transplantation registry. Transplants were divided into 2 donor-recipient matching groups: HLA-A–compatible (no HLA-A mismatches) and HLA-A–incompatible (1-2 HLA-A mismatches). Primary outcome was all-cause mortality. Secondary outcomes were graft failure-, cardiovascular-, infection-, or malignancy-related deaths. Results The risk of all-cause mortality 15 years after transplantation was higher for HLA-A–compatible (vs HLA-A–incompatible) grafts in patients who had HLA-B–, HLA-DR–, or HLA-B,DR–incompatible grafts (P = 0.027, P = 0.007, and P = 0.002, respectively) but not in HLA-B– and/or HLA-DR–compatible grafts. This was confirmed in multivariable Cox regression analysis where HLA-A compatibility (vs HLA-A incompatibility) was associated with higher mortality in transplants incompatible for HLA-DR or HLA-B and -DR (hazard ratio [HR], 1.59; 95% confidence interval [95% CI], 1.11-2.28; P = 0.012 and HR, 1.69; 95% CI, 1.17-2.43; P = 0.005, respectively). In multivariable analysis, the largest compromise in survival for HLA-A compatibility (vs HLA-incompatibility) was for chronic rejection in HLA-B– and -DR–incompatible grafts (HR, 1.91; 95% CI, 1.22-3.01; P = 0.005). Conclusions Decreased long-term survival in heart transplantation was associated with HLA-A compatibility in HLA-B,DR–incompatible grafts. PMID:27500238

The impact of ergonomics intervention on trunk posture and cumulative compression load among carpet weavers.

PubMed

Afshari, Davood; Motamedzade, Majid; Salehi, Reza; Soltanian, Alir Raze

2015-01-01

Work-related musculoskeletal disorders of back among weavers are prevalent. Epidemiological studies have shown an association between poor working postures and back disorders among carpet weavers. Therefore, the present study aimed to evaluate the impact of the traditional (A) and ergonomically designed (B) workstations on trunk posture and cumulative compression load in carpet weavers. In this study, subtasks were identified in terms of stressful postures and carpet weaving process. Postural data were collected during knotting and compacting subtasks using inclinometer during four hours for each workstation. Postural data, weight and height of the weavers were entered into the University of Michigan three-dimensional static biomechanical model for estimation of the compression load and cumulative load were estimated from the resultant load and exposure time. Thirteen healthy carpet weavers (four males and nine females) participated in the study. Median trunk flexion angle was reduced with workstation B during knotting subtask (18° versus 8.5°, p< 0.01 in males; 18.5° versus 7°, p< 0.001 in females). Average cumulative compression load was reduced with workstation B (22.17MN-s versus 16.68MN-s, p < 0.01 in males; 13.05 MN-s versus 10.14, p < 0.001 in females). Using workstation B led to significant decrease in cumulative compressive loading during an entire shift (8 hours), which indicates reduced level of stress on the back. It is suggested to conduct biomechanical studies on the shoulder and wrist regions in carpet weavers in order to achieve further development and improvement in the ergonomically designed workstation.

Task analysis of information technology-mediated medication management in outpatient care.

PubMed

van Stiphout, F; Zwart-van Rijkom, J E F; Maggio, L A; Aarts, J E C M; Bates, D W; van Gelder, T; Jansen, P A F; Schraagen, J M C; Egberts, A C G; ter Braak, E W M T

2015-09-01

Educating physicians in the procedural as well as cognitive skills of information technology (IT)-mediated medication management could be one of the missing links for the improvement of patient safety. We aimed to compose a framework of tasks that need to be addressed to optimize medication management in outpatient care. Formal task analysis: decomposition of a complex task into a set of subtasks. First, we obtained a general description of the medication management process from exploratory interviews. Secondly, we interviewed experts in-depth to further define tasks and subtasks. Outpatient care in different fields of medicine in six teaching and academic medical centres in the Netherlands and the United States. 20 experts. Tasks were divided up into procedural, cognitive and macrocognitive tasks and categorized into the three components of dynamic decision making. The medication management process consists of three components: (i) reviewing the medication situation; (ii) composing a treatment plan; and (iii) accomplishing and communicating a treatment and surveillance plan. Subtasks include multiple cognitive tasks such as composing a list of current medications and evaluating the reliability of sources, and procedural tasks such as documenting current medication. The identified macrocognitive tasks were: planning, integration of IT in workflow, managing uncertainties and responsibilities, and problem detection. All identified procedural, cognitive and macrocognitive skills should be included when designing education for IT-mediated medication management. The resulting framework supports the design of educational interventions to improve IT-mediated medication management in outpatient care. © 2015 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

Improving performance of natural language processing part-of-speech tagging on clinical narratives through domain adaptation.

PubMed

Ferraro, Jeffrey P; Daumé, Hal; Duvall, Scott L; Chapman, Wendy W; Harkema, Henk; Haug, Peter J

2013-01-01

Natural language processing (NLP) tasks are commonly decomposed into subtasks, chained together to form processing pipelines. The residual error produced in these subtasks propagates, adversely affecting the end objectives. Limited availability of annotated clinical data remains a barrier to reaching state-of-the-art operating characteristics using statistically based NLP tools in the clinical domain. Here we explore the unique linguistic constructions of clinical texts and demonstrate the loss in operating characteristics when out-of-the-box part-of-speech (POS) tagging tools are applied to the clinical domain. We test a domain adaptation approach integrating a novel lexical-generation probability rule used in a transformation-based learner to boost POS performance on clinical narratives. Two target corpora from independent healthcare institutions were constructed from high frequency clinical narratives. Four leading POS taggers with their out-of-the-box models trained from general English and biomedical abstracts were evaluated against these clinical corpora. A high performing domain adaptation method, Easy Adapt, was compared to our newly proposed method ClinAdapt. The evaluated POS taggers drop in accuracy by 8.5-15% when tested on clinical narratives. The highest performing tagger reports an accuracy of 88.6%. Domain adaptation with Easy Adapt reports accuracies of 88.3-91.0% on clinical texts. ClinAdapt reports 93.2-93.9%. ClinAdapt successfully boosts POS tagging performance through domain adaptation requiring a modest amount of annotated clinical data. Improving the performance of critical NLP subtasks is expected to reduce pipeline error propagation leading to better overall results on complex processing tasks.

Adaptive critic neural network-based object grasping control using a three-finger gripper.

PubMed

Jagannathan, S; Galan, Gustavo

2004-03-01

Grasping of objects has been a challenging task for robots. The complex grasping task can be defined as object contact control and manipulation subtasks. In this paper, object contact control subtask is defined as the ability to follow a trajectory accurately by the fingers of a gripper. The object manipulation subtask is defined in terms of maintaining a predefined applied force by the fingers on the object. A sophisticated controller is necessary since the process of grasping an object without a priori knowledge of the object's size, texture, softness, gripper, and contact dynamics is rather difficult. Moreover, the object has to be secured accurately and considerably fast without damaging it. Since the gripper, contact dynamics, and the object properties are not typically known beforehand, an adaptive critic neural network (NN)-based hybrid position/force control scheme is introduced. The feedforward action generating NN in the adaptive critic NN controller compensates the nonlinear gripper and contact dynamics. The learning of the action generating NN is performed on-line based on a critic NN output signal. The controller ensures that a three-finger gripper tracks a desired trajectory while applying desired forces on the object for manipulation. Novel NN weight tuning updates are derived for the action generating and critic NNs so that Lyapunov-based stability analysis can be shown. Simulation results demonstrate that the proposed scheme successfully allows fingers of a gripper to secure objects without the knowledge of the underlying gripper and contact dynamics of the object compared to conventional schemes.

FINAL TECHNICAL REPORT FOR FORESTRY BIOFUEL STATEWIDE COLLABORATION CENTER (MICHIGAN)

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaCourt, Donna M.; Miller, Raymond O.; Shonnard, David R.

A team composed of scientists from Michigan State University (MSU) and Michigan Technological University (MTU) assembled to better understand, document, and improve systems for using forest-based biomass feedstocks in the production of energy products within Michigan. Work was funded by a grant (DE-EE-0000280) from the U.S. Department of Energy (DOE) and was administered by the Michigan Economic Development Corporation (MEDC). The goal of the project was to improve the forest feedstock supply infrastructure to sustainably provide woody biomass for biofuel production in Michigan over the long-term. Work was divided into four broad areas with associated objectives: • TASK A: Developmore » a Forest-Based Biomass Assessment for Michigan – Define forest-based feedstock inventory, availability, and the potential of forest-based feedstock to support state and federal renewable energy goals while maintaining current uses. • TASK B: Improve Harvesting, Processing and Transportation Systems – Identify and develop cost, energy, and carbon efficient harvesting, processing and transportation systems. • TASK C: Improve Forest Feedstock Productivity and Sustainability – Identify and develop sustainable feedstock production systems through the establishment and monitoring of a statewide network of field trials in forests and energy plantations. • TASK D: Engage Stakeholders – Increase understanding of forest biomass production systems for biofuels by a broad range of stakeholders. The goal and objectives of this research and development project were fulfilled with key model deliverables including: 1) The Forest Biomass Inventory System (Sub-task A1) of feedstock inventory and availability and, 2) The Supply Chain Model (Sub-task B2). Both models are vital to Michigan’s forest biomass industry and support forecasting delivered cost, as well as carbon and energy balance. All of these elements are important to facilitate investor, operational and policy decisions. All other sub-tasks supported the development of these two tools either directly or by building out supporting information in the forest biomass supply chain. Outreach efforts have, and are continuing to get these user friendly models and information to decision makers to support biomass feedstock supply chain decisions across the areas of biomass inventory and availability, procurement, harvest, forwarding, transportation and processing. Outreach will continue on the project website at http://www.michiganforestbiofuels.org/ and http://www.michiganwoodbiofuels.org/« less

Preclinical evaluation of an MR-compatible microwave ablation system and comparison with a standard microwave ablation system in an ex vivo bovine liver model.

PubMed

Hoffmann, Rüdiger; Kessler, David-Emanuel; Weiss, Jakob; Clasen, Stephan; Pereira, Philippe L; Nikolaou, Konstantin; Rempp, Hansjörg

2017-09-01

Evaluation of a newly developed MR-compatible microwave ablation system with focus on ablation performance and comparison with a corresponding standard microwave ablation system. A total of 52 ablations were performed with a non-cooled microwave ablation system in an ex vivo bovine liver model using the following settings: [A] 16G-standard antenna, 2 cm active tip, 2.4 m cable; [B] MR-compatible 16G-antenna, 2 cm active tip, 2.4 m cable; [C] MR-compatible 16G-antenna, 2 cm active tip, extended 6 m cable; and [D] MR-compatible 16G-antenna, 4 cm active tip, extended 6 m cable. Ablation durations were 3, 5 and 10 min, and additionally 15 min for [D]. Ablations zones were measured for short-axis diameter (SA) and long-axis diameter (LA). Settings [A]-[C] were compared regarding SA, volume (V) and generator energy output (E) with analysis of variance and Tukey-Kramer post hoc test. Ablation performance of the MR-compatible settings [C] and [D] were compared regarding SA, V, E and sphericity index (SA/LA) with unpaired t-test. p < 0.05 was considered as statistically significant. No significant differences were found between [A], [B] and [C] regarding SA and V (10 min; SA[A] = 25.8 ± 2.4 mm, SA[B] = 25.3 ± 1.9 mm, SA[C] = 25.0 ± 2.0 mm, p = 0.88; V[A] = 17.8 ± 4.4 cm³, V[B] = 16.6 ± 3.0 cm³, V[C] = 17.8 ± 2.7 cm³, p = 0.85); however, the highest energy output was measured for setting [C] (10 min; [A]: 9.9 ± 0.5 kJ, [B]: 10.1 ± 0.5 kJ, [C]: 13.1 ± 0.3 kJ, p < 0.001). SA, V and E were significantly larger with setting [D] than [C] with 10 min ablations (SA[C] = 25.0 ± 2.0 mm, SA[D] = 34.0 ± 2.9 mm, p = 0.003; V[C] = 17.8 ± 2.7 cm³, V[D] = 39.4 ± 7.5 cm³, p = 0.007; E[C] = 13.1 ± 0.3 kJ, E[D] = 16.7 ± 0.8 kJ, p = 0.002) without significant difference in sphericity index (SA/LA[C] = 0.46 ± 0.02, SA/LA[D] = 0.52 ± 0.04, p = 0.08). The tested MR-compatible system can be used without loss of ablation performance compared to the standard system.

Obsessive-compulsive tendencies are associated with a focused information processing strategy.

PubMed

Soref, Assaf; Dar, Reuven; Argov, Galit; Meiran, Nachshon

2008-12-01

The study examined the hypothesis that obsessive-compulsive (OC) tendencies are related to a reliance on focused and serial rather than a parallel, speed-oriented information processing style. Ten students with high OC tendencies and 10 students with low OC tendencies performed the flanker task, in which they were required to quickly classify a briefly presented target letter (S or H) that was flanked by compatible (e.g., SSSSS) or incompatible (e.g., HHSHH) noise letters. Participants received 4 blocks of 100 trials each, two with 50% compatible trials and two with 80% compatible trials and were informed of the probability of compatible trials before the beginning of each block. As predicted, high OC participants, as compared to low OC participants, had slower overall reaction time (RT) and lower tendency for parallel processing (defined as incompatible trials RT minus compatible trials RT). Low, more than high OC participants tended to adjust their focused/parallel processing including a shift towards parallel processing in blocks with 80% compatible trials and in trials following compatible trials. Implications of these results to the cognitive theory and therapy of OCD are discussed.

Comparing handheld and hands-free cell phone usage behaviors while driving.

PubMed

Soccolich, Susan A; Fitch, Gregory M; Perez, Miguel A; Hanowski, Richard J

2014-01-01

The goal of this study was to compare cell phone usage behaviors while driving across 3 types of cell phones: handheld (HH) cell phones, portable hands-free (PHF) cell phones, and integrated hands-free (IHF) cell phones. Naturalistic driving data were used to observe HH, PHF, and IHF usage behaviors in participants' own vehicles without any instructions or manipulations by researchers. In addition to naturalistic driving data, drivers provided their personal cell phone call records. Calls during driving were sampled and observed in naturalistically collected video. Calls were reviewed to identify cell phone type used for, and duration of, cell phone subtasks, non-cell phone secondary tasks, and other use behaviors. Drivers in the study self-identified as HH, PHF, or IHF users if they reported using that cell phone type at least 50% of the time. However, each sampled call was classified as HH, PHF, or IHF if the talking/listening subtask was conducted using that cell phone type, without considering the driver's self-reported group. Drivers with PHF or IHF systems also used HH cell phones (IHF group used HH cell phone in 53.2% of the interactions, PHF group used HH cell phone for 55.5% of interactions). Talking/listening on a PHF phone or an IHF phone was significantly longer than talking/listening on an HH phone (P <.05). HH dialing was significantly longer in duration than PHF or IHF begin/answer tasks. End phone call task for HH phones was significantly longer in duration than the end phone call task for PHF and IHF phones. Of all the non-cell phone-related secondary tasks, eating or drinking was found to occur significantly more often during IHF subtasks (0.58%) than in HH subtasks (0.15%). Drivers observed to reach for their cell phone mostly kept their cell phone in the cup holder (36.3%) or in their seat or lap (29.0% of interactions); however, some observed locations may have required drivers to move out of position. Hands-free cell phone technologies reduce the duration of cell phone visual-manual tasks compared to handheld cell phones. However, drivers with hands-free cell phone technologies available to them still choose to use handheld cell phones to converse or complete cell phone visual-manual tasks for a noteworthy portion of interactions.

Chemical Looping Combustion Reactions and Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarofim, Adel; Lighty, JoAnn; Smith, Philip

2014-03-01

Chemical Looping Combustion (CLC) is one promising fuel-combustion technology, which can facilitate economic CO{sub 2} capture in coal-fired power plants. It employs the oxidation/reduction characteristics of a metal, or oxygen carrier, and its oxide, the oxidizing gas (typically air) and the fuel source may be kept separate. This topical report discusses the results of four complementary efforts: (5.1) the development of process and economic models to optimize important design considerations, such as oxygen carrier circulation rate, temperature, residence time; (5.2) the development of high-performance simulation capabilities for fluidized beds and the collection, parameter identification, and preliminary verification/uncertainty quantification; (5.3) themore » exploration of operating characteristics in the laboratoryscale bubbling bed reactor, with a focus on the oxygen carrier performance, including reactivity, oxygen carrying capacity, attrition resistance, resistance to deactivation, cost and availability; and (5.4) the identification of kinetic data for copper-based oxygen carriers as well as the development and analysis of supported copper oxygen carrier material. Subtask 5.1 focused on the development of kinetic expressions for the Chemical Looping with Oxygen Uncoupling (CLOU) process and validating them with reported literature data. The kinetic expressions were incorporated into a process model for determination of reactor size and oxygen carrier circulation for the CLOU process using ASPEN PLUS. An ASPEN PLUS process model was also developed using literature data for the CLC process employing an iron-based oxygen carrier, and the results of the process model have been utilized to perform a relative economic comparison. In Subtask 5.2, the investigators studied the trade-off between modeling approaches and available simulations tools. They quantified uncertainty in the high-performance computing (HPC) simulation tools for CLC bed applications. Furthermore, they performed a sensitivity analysis for velocity, height and polydispersity and compared results against literature data for experimental studies of CLC beds with no reaction. Finally, they present an optimization space using simple non-reactive configurations. In Subtask 5.3, through a series of experimental studies, behavior of a variety of oxygen carriers with different loadings and manufacturing techniques was evaluated under both oxidizing and reducing conditions. The influences of temperature, degree of carrier conversion and thermodynamic driving force resulting from the difference between equilibrium and system O{sub 2} partial pressures were evaluated through several experimental campaigns, and generalized models accounting for these influences were developed to describe oxidation and oxygen release. Conversion of three solid fuels with widely ranging reactivities was studied in a small fluidized bed system, and all but the least reactive fuel (petcoke) were rapidly converted by oxygen liberated from the CLOU carrier. Attrition propensity of a variety of carriers was also studied, and the carriers produced by freeze granulation or impregnation of preformed substrates displayed the lowest rates of attrition. Subtask 5.4 focused on gathering kinetic data for a copper-based oxygen carrier to assist with modeling of a functioning chemical looping reactor. The kinetics team was also responsible for the development and analysis of supported copper oxygen carrier material.« less

Hydrocarbon-fuel/combustion-chamber-liner materials compatibility

NASA Technical Reports Server (NTRS)

Gage, Mark L.

1990-01-01

Results of material compatibility experiments using hydrocarbon fuels in contact with copper-based combustion chamber liner materials are presented. Mil-Spec RP-1, n- dodecane, propane, and methane fuels were tested in contact with OFHC, NASA-Z, and ZrCu coppers. Two distinct test methods were employed. Static tests, in which copper coupons were exposed to fuel for long durations at constant temperature and pressure, provided compatibility data in a precisely controlled environment. Dynamic tests, using the Aerojet Carbothermal Test Facility, provided fuel and copper compatibility data under realistic booster engine service conditions. Tests were conducted using very pure grades of each fuel and fuels to which a contaminant, e.g., ethylene or methyl mercaptan, was added to define the role played by fuel impurities. Conclusions are reached as to degradation mechanisms and effects, methods for the elimination of these mechanisms, selection of copper alloy combustion chamber liners, and hydrocarbon fuel purchase specifications.

Intrasystem Electromagnetic Compatibility Analysis Program. Volume 1. User’s Manual Engineering Section

DTIC Science & Technology

1974-12-01

AD-A008 526 INTRASYSTEM ELECTROMAGNETIC COMPATI- BILITY ANALYSIS PROGRAM. VOLUME I. USER’S MANUAL ENGINEERING SECTION J. L. Bogdanor , et al McDonnell...e) 8 CONTRACT OR GRANT NUMBERfs) J.L. Bogdanor F30602-72-C-0277 R.A. Pearlman M.D. Siegel PERFORMING ORGANIZATION NAME AND ADDRESS I0 PROGRAM ELEMENT...June 1968. 14. J. L. Bogdanor , M. D. Siegel, G. L. Weinstock, "Intra-Vehicle Electromagnetic Compatibility Analysis," AFAL-TR-71-155, July 1971. 15

Anthropometric Cockpit Compatibility Assessment of US Army Aircraft for Large and Small Personnel Wearing a Training, Warm-Weather Clothing Configuration

DTIC Science & Technology

1984-07-01

SUPPLEMENTARY NOTES 19. KEY WORDS (Continue on rover&* side If necessary and Identify by block number) Anthropometry , Cockpit Compatibility, Aircraft...report is one of a series of reports on anthropometry in US Army Aviation produced by the US Army Aeromedical Research Laboratory (USAARL...and stick (OV-1D). 4 , 26 *w. I.. REFERENCES Churchill, E., Churchill, T., McConville, J.T., and White, R.M. 1977. Anthropometry of women of the U.S

Evaluation of Lands for Recreational Snowmobile Use (Guidelines for Natural Resources Management and Land Use Compatibility).

DTIC Science & Technology

1981-05-01

Percy , E. C., "The Snowmobile: Friend or Foe?" Journal of Trauma, Vol 12, No. 5 (May 1972), pp 444-446. Price, V. J., "Snowmobiles, The Winter Revolution...Fort Dix, NJ Hasset, John J., Agronomy Department, University of Illinois, Champaign, IL Huber, Phil, Environmental Offices, Fort Benning, GA Jackson ...Outdoor Recreation Director, Fort McCoy, WI Houser, James, Forester, Fort McCoy, WI Hutchinson, Julian, Land Manager, Fort McCoy, WI Jackson , Gary

Rapid Response R&D for the Propulsion Directorate. Delivery Order 0019: Advanced Alternative Energy Technologies, Subtask: Life Cycle Greenhouse Gas Analysis of Advanced Jet Propulsion Fuels: Fischer-Tropsch Based SPK-1 Case Study

DTIC Science & Technology

2011-09-01

carry finished jet fuel from the CBTL facility. The pipeline connects the CBTL facility to a petroleum refinery located in Wood River, Illinois...Under Option 1, all the blended jet fuel is transported via pipeline from the refinery in Wood River to Chicago’s O’Hare airport. Under Option 2...shipping F-T jet fuel to a refinery in Wood River, Illinois (near St. Louis, Missouri) for blending and final transport of the blended jet fuel to

Task 4 supporting technology. Part 2: Detailed test plan for thermal seals. Thermal seals evaluation, improvement and test. CAN8-1, Reusable Launch Vehicle (RLV), advanced technology demonstrator: X-33. Leading edge and seals thermal protection system technology demonstration

NASA Technical Reports Server (NTRS)

Hogenson, P. A.; Lu, Tina

1995-01-01

The objective is to develop the advanced thermal seals to a technology readiness level (TRL) of 6 to support the rapid turnaround time and low maintenance requirements of the X-33 and the future reusable launch vehicle (RLV). This program is divided into three subtasks: (1) orbiter thermal seals operation history review; (2) material, process, and design improvement; and (3) fabrication and evaluation of the advanced thermal seals.

Compatibility of high-Δm2 νe and ν¯e neutrino oscillation searches

NASA Astrophysics Data System (ADS)

Aguilar-Arevalo, A. A.; Anderson, C. E.; Bazarko, A. O.; Brice, S. J.; Brown, B. C.; Bugel, L.; Cao, J.; Coney, L.; Conrad, J. M.; Cox, D. C.; Curioni, A.; Djurcic, Z.; Finley, D. A.; Fleming, B. T.; Ford, R.; Garcia, F. G.; Garvey, G. T.; Green, C.; Green, J. A.; Hart, T. L.; Hawker, E.; Imlay, R.; Johnson, R. A.; Karagiorgi, G.; Kasper, P.; Katori, T.; Kobilarcik, T.; Kourbanis, I.; Koutsoliotas, S.; Laird, E. M.; Linden, S. K.; Link, J. M.; Liu, Y.; Liu, Y.; Louis, W. C.; Mahn, K. B. M.; Marsh, W.; Martin, P. S.; McGregor, G.; Metcalf, W.; Meyers, P. D.; Mills, F.; Mills, G. B.; Monroe, J.; Moore, C. D.; Nelson, R. H.; Nguyen, V. T.; Nienaber, P.; Ouedraogo, S.; Patterson, R. B.; Perevalov, D.; Polly, C. C.; Prebys, E.; Raaf, J. L.; Ray, H.; Roe, B. P.; Russell, A. D.; Sandberg, V.; Schirato, R.; Schmitz, D.; Shaevitz, M. H.; Shoemaker, F. C.; Smith, D.; Soderberg, M.; Sorel, M.; Spentzouris, P.; Stancu, I.; Stefanski, R. J.; Sung, M.; Tanaka, H. A.; Tayloe, R.; Tzanov, M.; van de Water, R.; Wascko, M. O.; White, D. H.; Wilking, M. J.; Yang, H. J.; Zeller, G. P.; Zimmerman, E. D.

2008-07-01

This article presents the compatibility of experimental data from neutrino oscillation experiments with a high-Δm2 two-neutrino oscillation hypothesis. Data is provided by the Bugey, Karlsruhe Rutherford Medium Energy Neutrino Experiment 2 (KARMEN2), Los Alamos Liquid Scintillator Neutrino Detector (LSND), and MiniBooNE experiments. The LSND, KARMEN2, and MiniBooNE results are 25.36% compatible within a two-neutrino oscillation hypothesis. However, the point of maximal compatibility is found in a region that is excluded by the Bugey data. A joint analysis of all four experiments, performed in the sin⁡22θvsΔm2 region common to all data, finds a maximal compatibility of 3.94%. This result does not account for additions to the neutrino oscillation model from sources such as CP violation or sterile neutrinos.

New-generation bar adsorptive microextraction (BAμE) devices for a better eco-user-friendly analytical approach-Application for the determination of antidepressant pharmaceuticals in biological fluids.

PubMed

Ide, A H; Nogueira, J M F

2018-05-10

The present contribution aims to design new-generation bar adsorptive microextraction (BAμE) devices that promote an innovative and much better user-friendly analytical approach. The novel BAμE devices were lab-made prepared having smaller dimensions by using flexible nylon-based supports (7.5 × 1.0 mm) coated with convenient sorbents (≈ 0.5 mg). This novel advance allows effective microextraction and back-extraction ('only single liquid desorption step') stages as well as interfacing enhancement with the instrumental systems dedicated for routine analysis. To evaluate the achievements of these improvements, four antidepressant agents (bupropion, citalopram, amitriptyline and trazodone) were used as model compounds in aqueous media combined with liquid chromatography (LC) systems. By using an N-vinylpyrrolidone based-polymer phase good selectivity and efficiency were obtained. Assays performed on 25 mL spiked aqueous samples, yielded average recoveries in between 67.8 ± 12.4% (bupropion) and 88.3 ± 12.1% (citalopram), under optimized experimental conditions. The analytical performance also showed convenient precision (RSD < 12%) and detection limits (50 ng L -1 ), as well as linear dynamic ranges (160-2000 ng L -1 ) with suitable determination coefficients (r 2  > 0.9820). The application of the proposed analytical approach on biological fluids showed negligible matrix effects by using the standard addition methodology. From the data obtained, the new-generation BAμE devices presented herein provide an innovative and robust analytical cycle, are simple to prepare, cost-effective, user-friendly and compatible with the current LC autosampler systems. Furthermore, the novel devices were designed to be disposable and used together with negligible amounts of organic solvents (100 μL) during back-extraction, in compliance with the green analytical chemistry principles. In short, the new-generation BAμE devices showed to be an eco-user-friendly approach for trace analysis of priority compounds in biological fluids and a versatile alternative over other well-stablished sorption-based microextraction techniques. Copyright © 2018 Elsevier B.V. All rights reserved.

Band gap tuning of armchair silicene nanoribbons using periodic hexagonal holes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mehdi Aghaei, Sadegh; Calizo, Irene, E-mail: icalizo@fiu.edu

2015-09-14

The popularity of graphene owing to its unique and exotic properties has triggered a great deal of interest in other two-dimensional nanomaterials. Among them silicene shows considerable promise for electronic devices with a carrier mobility comparable to graphene, flexible buckled structure, and expected compatibility with silicon electronics. Using first-principle calculations based on density functional theory, the electronic properties of armchair silicene nanoribbons perforated with periodic nanoholes (ASiNRPNHs) are investigated. Two different configurations of mono-hydrogenated (:H) and di-hydrogenated (:2H) silicene edges are considered. Pristine armchair silicene nanoribbons (ASiNRs) can be categorized into three branches with width W = 3P − 1, 3P, andmore » 3P + 1, P is an integer. The order of their energy gaps change from “E{sub G} (3P − 1) < E{sub G} (3P) < E{sub G} (3P + 1)” for W-ASiNRs:H to “E{sub G} (3P + 1) < E{sub G} (3P − 1) < E{sub G} (3P)” for W-ASiNRs:2H. We found the band gaps of W-ASiNRs:H and (W + 2)-ASiNRs:2H are slightly different, giving larger band gaps for wider ASiNRs:2H. ASiNRPNHs' band gaps changed based on the nanoribbon's width, nanohole's repeat periodicity and position relative to the nanoribbon's edge compared to pristine ASiNRs because of changes in quantum confinement strength. ASiNRPNHs:2H are more stable than ASiNRPNHs:H and their band gaps are noticeably greater than ASiNRPNHs:H. We found that the value of energy band gap for 12-ASiNRPNHs:2H with repeat periodicity of 2 is 0.923 eV. This value is about 2.2 times greater than pristine ASiNR:2H and double that of the 12-ASiNRPNHs:H with repeat periodicity of 2.« less

Adaptive Correlation Concepts for Non-Compatible Imagery.

DTIC Science & Technology

1981-10-31

5.4 Ohio Files 26 and 27 Image Segments . . . . 34 5.5 HSV Files 9 and 10 Image Segments ..... . 35 5.6 Scene 1 , Vertical Profiles Through Peak...Simulation Options Summary .e m "lch c .i a ir t.e j-r.-ct cross c t.e"P- lat absclut - differcr.ce a!a .u iy-i.cidd dif’err.c; - metrics. e 1 T0 1ff ct of...cdlf o spectral bands, di~ffe,-,-rurt tie f loy. "Ind d:;7o T hes’,-e -simu lat i onso ae 1 - s o2( 1 r 1 b- in th I s-,sI 31. / / s. ILI Z1.I I SO .& i

First annual report SHRP C103 task 4 : rapid repair techniques.

DOT National Transportation Integrated Search

1989-01-01

The objective of task four is to develop technically and economically feasible methods of concrete bridge deck protection, rehabilitation, and replacement. The objective of the task will be accomplished through a progression of six subtasks. The subt...

HRP Integrated Research Plan Analysis

NASA Technical Reports Server (NTRS)

Elliott, Todd

2009-01-01

The charts, that are the totality of this document, presents tasks, duration of the tasks, the start and finish of the tasks, and subtasks. Also presented are PERT charts that display the beginning, external milestones, and end points for the tasks, and sub tasks.

Incorporating Health Education into Employee Assistance Programs.

ERIC Educational Resources Information Center

Miller, Richard E.

1985-01-01

Methods of aligning health education with the goals and functions of employee assistance programs are discussed. The role of the health educator in developing these programs is explained in a description of employee assistance program service standards and specific sub-tasks. (DF)

Crystallographic features of the martensitic transformation and their impact on variant organization in the intermetallic compound Ni50Mn38Sb12 studied by SEM/EBSD.

PubMed

Zhang, Chunyang; Zhang, Yudong; Esling, Claude; Zhao, Xiang; Zuo, Liang

2017-09-01

The mechanical and magnetic properties of Ni-Mn-Sb intermetallic compounds are closely related to the martensitic transformation and martensite variant organization. However, studies of these issues are very limited. Thus, a thorough crystallographic investigation of the martensitic transformation orientation relationship (OR), the transformation deformation and their impact on the variant organization of an Ni 50 Mn 38 Sb 12 alloy using scanning electron microscopy/electron backscatter diffraction (SEM/EBSD) was conducted in this work. It is shown that the martensite variants are hierarchically organized into plates, each possessing four distinct twin-related variants, and the plates into plate colonies, each containing four distinct plates delimited by compatible and incompatible plate interfaces. Such a characteristic organization is produced by the martensitic transformation. It is revealed that the transformation obeys the Pitsch relation ({0[Formula: see text]} A // {2[Formula: see text]} M and 〈0[Formula: see text]1〉 A // 〈[Formula: see text]2〉 M ; the subscripts A and M refer to austenite and martensite, respectively). The type I twinning plane K 1 of the intra-plate variants and the compatible plate interface plane correspond to the respective orientation relationship planes {0[Formula: see text]} A and {0[Formula: see text]} A of austenite. The three {0[Formula: see text]} A planes possessed by each pair of compatible plates, one corresponding to the compatible plate interface and the other two to the variants in the two plates, are interrelated by 60° and belong to a single 〈11[Formula: see text]〉 A axis zone. The {0[Formula: see text]} A planes representing the two pairs of compatible plates in each plate colony belong to two 〈11[Formula: see text]〉 A axis zones having one {0[Formula: see text]} A plane in common. This common plane defines the compatible plate interfaces of the two pairs of plates. The transformation strains to form the variants in the compatible plates are compatible and demonstrate an edge-to-edge character. Thus, such plates should nucleate and grow simultaneously. On the other hand, the strains to form the variants in the incompatible plates are incompatible, so they nucleate and grow separately until they meet during the transformation. The results of the present work provide comprehensive information on the martensitic transformation of Ni-Mn-Sb intermetallic compounds and its impact on martensite variant organization.

Emodin self-emulsifying platform ameliorates the expression of FN, ICAM-1 and TGF-β1 in AGEs-induced glomerular mesangial cells by promoting absorption.

PubMed

Huang, Jiani; Gong, Wenyan; Chen, Zhiquan; Huang, Junying; Chen, Qiuhong; Huang, Heqing; Zhao, Chunshun

2017-03-01

Emodin, a potential anti-diabetic nephropathy agent, is limited by its oral use due to the poor water solubility. The present study aimed to enhance the absorption and the suppressive effects of emodin on renal fibrosis by developing a self-microemulsifying drug delivery system (SMEDDS). Solubility studies, compatibility tests, pseudo-ternary phase diagrams analysis and central composite design were carried out to obtain the optimized formulation. The average droplet size of emodin-loaded SMEDDS was about 18.31±0.12nm, and the droplet size and zeta potential remained stable at different dilution ratios of water and different values of pH varying from 1.2 to 7.2. Enhanced cellular uptake in both the Caco-2 cells and glomerular mesangial cells (GMCs) is great advantageous for the formulation. The AUC 0-24h of emodin-loaded SMEDDS was 1.87-fold greater than that of emodin suspension, which may be attributed to enhanced uptake in Caco-2 cells. Moreover, emodin-loaded SMEDDS showed better suppressive effects on the protein level of fibronectin (FN), transforming growth factor-beta 1 (TGF-β1) and intercellular adhesion molecule 1 (ICAM-1) than the crude emodin in advanced glycation-end products (AGEs)-induced GMCs and renal tubular epithelial cells (NRK-52E). Our study illustrated that developed SMEDDS improved the oral absorption of emodin, and attained better suppressive effects on the protein level of renal fibrosis compositions in AGEs-induced GMCs and NRK-52E cells. Copyright © 2016 Elsevier B.V. All rights reserved.

Holding a manual response sequence in memory can disrupt vocal responses that share semantic features with the manual response.

PubMed

Fournier, Lisa Renee; Wiediger, Matthew D; McMeans, Ryan; Mattson, Paul S; Kirkwood, Joy; Herzog, Theibot

2010-07-01

Holding an action plan in memory for later execution can delay execution of another action if the actions share a similar (compatible) feature. This compatibility interference (CI) occurs for actions that share the same response modality (e.g., manual response). We investigated whether CI can generalize to actions that utilize different response modalities (manual and vocal). In three experiments, participants planned and withheld a sequence of key-presses with the left- or right-hand based on the visual identity of the first stimulus, and then immediately executed a speeded, vocal response ('left' or 'right') to a second visual stimulus. The vocal response was based on discriminating stimulus color (Experiment 1), reading a written word (Experiment 2), or reporting the antonym of a written word (Experiment 3). Results showed that CI occurred when the manual response hand (e.g., left) was compatible with the identity of the vocal response (e.g., 'left') in Experiment 1 and 3, but not in Experiment 2. This suggests that partial overlap of semantic codes is sufficient to obtain CI unless the intervening action can be accessed automatically (Experiment 2). These findings are consistent with the code occupation hypothesis and the general framework of the theory of event coding (Behav Brain Sci 24:849-878, 2001a; Behav Brain Sci 24:910-937, 2001b).

Improved method for mutagenicity testing of gaseous compounds by using a gas sampling bag.

PubMed

Araki, A; Noguchi, T; Kato, F; Matsushima, T

1994-05-01

A simple and safety gas exposure method was developed using a gas sampling bag as an exposure vessel and a preparation vessel of diluted gas. The gas exposure conditions such as amount of S9 in the plate, volume of gas for the plate, amount of top agar, exposure period and exposure temperature were examined by mutagenicity testing of 1,3-butadiene using the gas sampling bag. Mutagenicity tests of 14 compounds and 1,3-butadiene on S. typhimurium TA98, TA100, TA1535 and TA1537, and E. coli WP2 uvrA were also examined by the developed gas exposure method. 1,3-Butadiene, propyne (methyl acetylene), monochlorodifluoromethane, ethylchloride, diborane and silane were mutagenic. 1-Butene, 2-butene, 2-methylpropene, methyl vinyl ether, trichlorofluoromethane, dichlorodifluoromethane, 1,2-dichloro-1,1,2,2-tetrafluoroethane, 1,1-difluoroethane and phosphine were not mutagenic on S. typhimurium TA98, TA100, TA1535 and TA1537, and E. coli WP2 uvrA with or without metabolic activation. These results were compatible with a previous report, and this developed method has the advantage that it can be tested easily and safely for combustible and self-combustible substances such as 1,3-butadiene and silane.

Evaluation of Four Methods for Predicting Carbon Stocks of Korean Pine Plantations in Heilongjiang Province, China

PubMed Central

Gao, Huilin; Dong, Lihu; Li, Fengri; Zhang, Lianjun

2015-01-01

A total of 89 trees of Korean pine (Pinus koraiensis) were destructively sampled from the plantations in Heilongjiang Province, P.R. China. The sample trees were measured and calculated for the biomass and carbon stocks of tree components (i.e., stem, branch, foliage and root). Both compatible biomass and carbon stock models were developed with the total biomass and total carbon stocks as the constraints, respectively. Four methods were used to evaluate the carbon stocks of tree components. The first method predicted carbon stocks directly by the compatible carbon stocks models (Method 1). The other three methods indirectly predicted the carbon stocks in two steps: (1) estimating the biomass by the compatible biomass models, and (2) multiplying the estimated biomass by three different carbon conversion factors (i.e., carbon conversion factor 0.5 (Method 2), average carbon concentration of the sample trees (Method 3), and average carbon concentration of each tree component (Method 4)). The prediction errors of estimating the carbon stocks were compared and tested for the differences between the four methods. The results showed that the compatible biomass and carbon models with tree diameter (D) as the sole independent variable performed well so that Method 1 was the best method for predicting the carbon stocks of tree components and total. There were significant differences among the four methods for the carbon stock of stem. Method 2 produced the largest error, especially for stem and total. Methods 3 and Method 4 were slightly worse than Method 1, but the differences were not statistically significant. In practice, the indirect method using the mean carbon concentration of individual trees was sufficient to obtain accurate carbon stocks estimation if carbon stocks models are not available. PMID:26659257

47 CFR 68.112 - Hearing aid-compatibility.

Code of Federal Regulations, 2014 CFR

2014-10-01

... located on public property or in a semi-public location (e.g., drugstore, gas station, private club). (b... disabilities. (4) All credit card operated telephones, whether located on public property or in a semipublic location (e.g., drugstore, gas station, private club), unless a hearing aid compatible (as defined in § 68...

47 CFR 68.112 - Hearing aid-compatibility.

Code of Federal Regulations, 2013 CFR

2013-10-01

... located on public property or in a semi-public location (e.g., drugstore, gas station, private club). (b... disabilities. (4) All credit card operated telephones, whether located on public property or in a semipublic location (e.g., drugstore, gas station, private club), unless a hearing aid compatible (as defined in § 68...

47 CFR 68.112 - Hearing aid-compatibility.

Code of Federal Regulations, 2012 CFR

2012-10-01

... located on public property or in a semi-public location (e.g., drugstore, gas station, private club). (b... disabilities. (4) All credit card operated telephones, whether located on public property or in a semipublic location (e.g., drugstore, gas station, private club), unless a hearing aid compatible (as defined in § 68...

Haploinsufficiency for Translation Elongation Factor eEF1A2 in Aged Mouse Muscle and Neurons Is Compatible with Normal Function

PubMed Central

Griffiths, Lowri A.; Doig, Jennifer; Churchhouse, Antonia M. D.; Davies, Faith C. J.; Squires, Charlotte E.; Newbery, Helen J.; Abbott, Catherine M.

2012-01-01

Translation elongation factor isoform eEF1A2 is expressed in muscle and neurons. Deletion of eEF1A2 in mice gives rise to the neurodegenerative phenotype “wasted” (wst). Mice homozygous for the wasted mutation die of muscle wasting and neurodegeneration at four weeks post-natal. Although the mutation is said to be recessive, aged heterozygous mice have never been examined in detail; a number of other mouse models of motor neuron degeneration have recently been shown to have similar, albeit less severe, phenotypic abnormalities in the heterozygous state. We therefore examined the effects of ageing on a cohort of heterozygous +/wst mice and control mice, in order to establish whether a presumed 50% reduction in eEF1A2 expression was compatible with normal function. We evaluated the grip strength assay as a way of distinguishing between wasted and wild-type mice at 3–4 weeks, and then performed the same assay in older +/wst and wild-type mice. We also used rotarod performance and immunohistochemistry of spinal cord sections to evaluate the phenotype of aged heterozygous mice. Heterozygous mutant mice showed no deficit in neuromuscular function or signs of spinal cord pathology, in spite of the low levels of eEF1A2. PMID:22848658

An investigation of factors influencing healthcare workers' use and acceptance of e-learning in post-school healthcare education.

PubMed

Mikalsen, Marius; Walderhaug, Ståle

2009-01-01

The objective of the study presented here was to perform an empirical investigation on factors affecting healthcare workers acceptance and utilisation of e-learning in post-school healthcare education. E-learning benefits are realised when key features of e-learning are not only applied, but deemed useful, compatible with the learning process and supportive in order to reach the overall goals of the learning process. We conducted a survey of 14 state-enrolled nurses and skilled-workers within the field of healthcare in Norway. The results show that perceived compatibility and subjective norm explain system usage of the e-learning tool amongst the students. We found that the fact that the students considered the e-learning to be compatible with the course in question had a positive effect on e-learning tool usage. We also found support for factors such as facilitating conditions and ease of use leads to the e-learning tool being considered useful.

TRoPICALS: A Computational Embodied Neuroscience Model of Compatibility Effects

ERIC Educational Resources Information Center

Caligiore, Daniele; Borghi, Anna M.; Parisi, Domenico; Baldassarre, Gianluca

2010-01-01

Perceiving objects activates the representation of their affordances. For example, experiments on compatibility effects showed that categorizing objects by producing certain handgrips (power or precision) is faster if the requested responses are compatible with the affordance elicited by the size of objects (e.g., small or large). The article…

Mitochondrial Hsp60 Chaperonopathy Causes an Autosomal-Recessive Neurodegenerative Disorder Linked to Brain Hypomyelination and Leukodystrophy

PubMed Central

Magen, Daniella; Georgopoulos, Costa; Bross, Peter; Ang, Debbie; Segev, Yardena; Goldsher, Dorit; Nemirovski, Alexandra; Shahar, Eli; Ravid, Sarit; Luder, Anthony; Heno, Bayan; Gershoni-Baruch, Ruth; Skorecki, Karl; Mandel, Hanna

2008-01-01

Hypomyelinating leukodystrophies (HMLs) are disorders involving aberrant myelin formation. The prototype of primary HMLs is the X-linked Pelizaeus-Merzbacher disease (PMD) caused by mutations in PLP1. Recently, homozygous mutations in GJA12 encoding connexin 47 were found in patients with autosomal-recessive Pelizaeus-Merzbacher-like disease (PMLD). However, many patients of both genders with PMLD carry neither PLP1 nor GJA12 mutations. We report a consanguineous Israeli Bedouin kindred with clinical and radiological findings compatible with PMLD, in which linkage to PLP1 and GJA12 was excluded. Using homozygosity mapping and mutation analysis, we have identified a homozygous missense mutation (D29G) not previously described in HSPD1, encoding the mitochondrial heat-shock protein 60 (Hsp60) in all affected individuals. The D29G mutation completely segregates with the disease-associated phenotype. The pathogenic effect of D29G on Hsp60-chaperonin activity was verified by an in vivo E. coli complementation assay, which demonstrated compromised ability of the D29G-Hsp60 mutant protein to support E. coli survival, especially at high temperatures. The disorder, which we have termed MitCHAP-60 disease, can be distinguished from spastic paraplegia 13 (SPG13), another Hsp60-associated autosomal-dominant neurodegenerative disorder, by its autosomal-recessive inheritance pattern, as well as by its early-onset, profound cerebral involvement and lethality. Our findings suggest that Hsp60 defects can cause neurodegenerative pathologies of varying severity, not previously suspected on the basis of the SPG13 phenotype. These findings should help to clarify the important role of Hsp60 in myelinogenesis and neurodegeneration. PMID:18571143

Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

PubMed Central

Mohamed, Amir Ibrahim; Abd-Motagaly, Amr Mohamed Elsayed; Ahmed, Osama A. A.; Amin, Suzan; Mohamed Ali, Alaa Ibrahim

2017-01-01

A simple chemometric-assisted UV-spectrophotometric method was used to study the compatibility of clindamycin hydrochloride (HC1) with two commonly used natural controlled-release polymers, alginate (Ag) and chitosan (Ch). Standard mixtures containing 1:1, 1:2, and 1:0.5 w/w drug–polymer ratios were prepared and UV scanned. A calibration model was developed with partial least square (PLS) regression analysis for each polymer separately. Then, test mixtures containing 1:1 w/w drug–polymer ratios with different sets of drug concentrations were prepared. These were UV scanned initially and after three and seven days of storage at 25 °C. Using the calibration model, the drug recovery percent was estimated and a decrease in concentration of 10% or more from initial concentration was considered to indicate instability. PLS models with PC3 (for Ag) and PC2 (for Ch) showed a good correlation between actual and found values with root mean square error of cross validation (RMSECV) of 0.00284 and 0.01228, and calibration coefficient (R2) values of 0.996 and 0.942, respectively. The average drug recovery percent after three and seven days was 98.1 ± 2.9 and 95.4 ± 4.0 (for Ag), and 97.3 ± 2.1 and 91.4 ± 3.8 (for Ch), which suggests more drug compatibility with an Ag than a Ch polymer. Conventional techniques including DSC, XRD, FTIR, and in vitro minimum inhibitory concentration (MIC) for (1:1) drug–polymer mixtures were also performed to confirm clindamycin compatibility with Ag and Ch polymers. PMID:28275214

Semantic Classification of Diseases in Discharge Summaries Using a Context-aware Rule-based Classifier

PubMed Central

Solt, Illés; Tikk, Domonkos; Gál, Viktor; Kardkovács, Zsolt T.

2009-01-01

Objective Automated and disease-specific classification of textual clinical discharge summaries is of great importance in human life science, as it helps physicians to make medical studies by providing statistically relevant data for analysis. This can be further facilitated if, at the labeling of discharge summaries, semantic labels are also extracted from text, such as whether a given disease is present, absent, questionable in a patient, or is unmentioned in the document. The authors present a classification technique that successfully solves the semantic classification task. Design The authors introduce a context-aware rule-based semantic classification technique for use on clinical discharge summaries. The classification is performed in subsequent steps. First, some misleading parts are removed from the text; then the text is partitioned into positive, negative, and uncertain context segments, then a sequence of binary classifiers is applied to assign the appropriate semantic labels. Measurement For evaluation the authors used the documents of the i2b2 Obesity Challenge and adopted its evaluation measures: F1-macro and F1-micro for measurements. Results On the two subtasks of the Obesity Challenge (textual and intuitive classification) the system performed very well, and achieved a F1-macro = 0.80 for the textual and F1-macro = 0.67 for the intuitive tasks, and obtained second place at the textual and first place at the intuitive subtasks of the challenge. Conclusions The authors show in the paper that a simple rule-based classifier can tackle the semantic classification task more successfully than machine learning techniques, if the training data are limited and some semantic labels are very sparse. PMID:19390101

Spider silk MASP1 and MASP2 proteins as carbon fiber precursors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Randolph V

The objective of this project is to develop an unconventional non-petroleum based carbon fiber precursor which has the potential to be produced in high yield and quantities. Methods will be developed to produce pilot-scale quantities of fibers from spider silk proteins with mechanical properties at least 75% that of the natural dragline silk fibers in tensile strength and elongations of less than 5%. The precursor fibers will be converted to carbon fibers, with a goal of >250Ksi strength and 1-2% elongation. Cost analysis will be performed and the process optimized. Task 1: Subtask 1. Protein production: We exceeded the go/more » no go milestone of 1.0g/L of one of the spider silk protein (MSp2) purified last FY and have now increased from 5L to 500L fermentations. We have made a series of changes to the purification protocol from the initial report last FY. These led to a reduction in the time needed for the purification and reduced the purification costs by nearly 90%. Subtask 2. Fiber spinning: The major focus has been to produce more material to send 24 fiber thread to ONRL. We are still developing the methodology to successfully spin 24 fiber yarns. This involves both the spinning dope solutions as well as the methods to keep the fibers from fusing during the post spin stretch. The second area of focus has been to standardize the spin dopes for making the fibers. We now know that the conductivity (indicative of salt remaining with the protein after purification) is an important factor in successful spinning as is the pH. We now know that we need to be below 600 uS conductivity and that the most effective pH is protein dependent. Subtask 3. Silkworm silk: We have found the transgenic silkworms made using gene replacement at the fibroin light chain instead of heavy chain as we did previously have a higher tensile strength. See figures below showing the curve for the top end of the cocoon fibers. This tensile strength is the same as the average for spider dragline silk. Task 2. Carbonization: The major accomplishment in the latter part of the work is that the ONRL group has successfully heated the spider silk protein fibers all the way up to 1700°C and produced a very competitive carbon fiber based on mechanical properties. Several important factors were discovered during these initial trials: 1) the ramp speed for increasing the temperature is critical; 2) maintaining tension on the fiber during the heating process because as it is heated it tends to expand; and 3) narrow temperature window in which stretching the fiber during heating leads to much better final materials. Task 3. Techno-Economic Methods: The techno-economic analysis was expanded to determine the relative cost of production with the bacterial production system compared to the transgenic alfalfa and goat production systems. The comparisons show two important things. For all systems the key factor in the final price is the amount of spider silk protein produced for whatever measure of volume or weight is used. Second alfalfa can be the cheapest but is subject to the possible regulatory control unless the US develops a more comprehensive approach to GMOs. The silkworm analysis was not completed due to a variety of confounding factors. The primary one was that if the production were shifted overseas then the cost would likely be nearly equivalent to current silk prices of $5-15/kg. However if concerns about the location of production is important then it would need to be done in the US and initial costs would be much higher but if the later scenario is utilized then the cost would be lowered but it was not possible to calculate exact costs.« less

Silicon Carbide Power Devices and Integrated Circuits

NASA Technical Reports Server (NTRS)

Lauenstein, Jean-Marie; Casey, Megan; Samsel, Isaak; LaBel, Ken; Chen, Yuan; Ikpe, Stanley; Wilcox, Ted; Phan, Anthony; Kim, Hak; Topper, Alyson

2017-01-01

An overview of the NASA NEPP Program Silicon Carbide Power Device subtask is given, including the current task roadmap, partnerships, and future plans. Included are the Agency-wide efforts to promote development of single-event effect hardened SiC power devices for space applications.

Recursive Joins to Query Data Hierarchies in Microsoft Access

ERIC Educational Resources Information Center

Dadashzadeh, Mohammad

2007-01-01

Organizational charts (departments, sub-departments, sub-sub-departments, and so on), project work breakdown structures (tasks, subtasks, work packages, etc.), discussion forums (posting, response, response to response, etc.), family trees (parent, child, grandchild, etc.), manufacturing bill-of-material, product classifications, and document…

Information Presentation

NASA Technical Reports Server (NTRS)

Holden, Kritina; Sandor, A.; Thompson, S. G.; McCann, R. S.; Kaiser, M. K.; Begault, D. R.; Adelstein, B. D.; Beutter, B. R.; Stone, L. S.

2008-01-01

The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew on flight vehicles, surface landers and habitats, and during extra-vehicular activities (EVA). Designers of displays and controls for exploration missions must be prepared to select the text formats, label styles, alarms, electronic procedure designs, and cursor control devices that provide for optimal crew performance on exploration tasks. The major areas of work, or subtasks, within the Information Presentation DRP are: 1) Controls, 2) Displays, 3) Procedures, and 4) EVA Operations.

Structured Analysis of the Logistic Support Analysis (LSA) Task, and Integrated Logistic Support (ILS) Element, LSA Subtask 301.2.4.2, Reliability Centered Maintenance (RCM)

DTIC Science & Technology

1988-06-01

Di’Lt. ibu601’. I j I o; DTIC Qt.ALTTY I ,2,1 4 AMERICAN POWER JET COMPANY RIDGEFIELD, NJ FALLS CHURCH...The logic is applied to each reparable item in the system/equipment. When the components have been analyzed, an overall system/equipment analysis is...in the AMSDL as applicable to the referenced DIDs of interest. 5. Apply staff experience in logistics support analysis to assure that the intent of the

Phase I Trial of Intratumoral Administration of NIS-Expressing Strain of Measles Virus in Unresectable or Recurrent Malignant Peripheral Nerve Sheath Tumor

DTIC Science & Technology

2017-10-01

Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Study approved by Mayo IRB on April 18 , 2016, and by USAMRMC/ORP/HRPO on May 6, 2016. All...Sheath Tumor(MPNST), MV-NIS, Oncolytic Virus, Measles Virus 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18 . NUMBER OF PPAGES 19a. NAME...virus incorporation and persistence in MPNST after injection Subtask 2: Assess viremia and viral shedding 1. Received Mayo IRB approval on 04/ 18 /2016

Parallel workflow manager for non-parallel bioinformatic applications to solve large-scale biological problems on a supercomputer.

PubMed

Suplatov, Dmitry; Popova, Nina; Zhumatiy, Sergey; Voevodin, Vladimir; Švedas, Vytas

2016-04-01

Rapid expansion of online resources providing access to genomic, structural, and functional information associated with biological macromolecules opens an opportunity to gain a deeper understanding of the mechanisms of biological processes due to systematic analysis of large datasets. This, however, requires novel strategies to optimally utilize computer processing power. Some methods in bioinformatics and molecular modeling require extensive computational resources. Other algorithms have fast implementations which take at most several hours to analyze a common input on a modern desktop station, however, due to multiple invocations for a large number of subtasks the full task requires a significant computing power. Therefore, an efficient computational solution to large-scale biological problems requires both a wise parallel implementation of resource-hungry methods as well as a smart workflow to manage multiple invocations of relatively fast algorithms. In this work, a new computer software mpiWrapper has been developed to accommodate non-parallel implementations of scientific algorithms within the parallel supercomputing environment. The Message Passing Interface has been implemented to exchange information between nodes. Two specialized threads - one for task management and communication, and another for subtask execution - are invoked on each processing unit to avoid deadlock while using blocking calls to MPI. The mpiWrapper can be used to launch all conventional Linux applications without the need to modify their original source codes and supports resubmission of subtasks on node failure. We show that this approach can be used to process huge amounts of biological data efficiently by running non-parallel programs in parallel mode on a supercomputer. The C++ source code and documentation are available from http://biokinet.belozersky.msu.ru/mpiWrapper .

CRAB NEBULA: FIVE-YEAR OBSERVATION WITH ARGO-YBJ

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartoli, B.; Catalanotti, S.; D'Ettorre Piazzoli, B.

2015-01-10

The ARGO-YBJ air shower detector monitored the Crab Nebula gamma-ray emission from 2007 November to 2013 February. The integrated signal, consisting of ∼3.3 × 10{sup 5} events, reached the statistical significance of 21.1 standard deviations. The obtained energy spectrum in the energy range 0.3-20 TeV can be described by a power law function dN/dE = I {sub 0} (E/2 TeV){sup –α}, with a flux normalization I {sub 0} = (5.2 ± 0.2) × 10{sup –12} photons cm{sup –2} s{sup –1} TeV{sup –1} and α = 2.63 ± 0.05, corresponding to an integrated flux above 1 TeV of 1.97 × 10{sup –11} photons cm{supmore » –2} s{sup –1}. The systematic error is estimated to be less than 30% for the flux normalization and 0.06 for the spectral index. Assuming a power law spectrum with an exponential cutoff dN/dE = I {sub 0} (E/2 TeV){sup –α} exp (–E/E {sub cut}), the lower limit of the cutoff energy E {sub cut} is 12 TeV, at 90% confidence level. Our extended data set allows the study of the TeV emission over long timescales. Over five years, the light curve of the Crab Nebula in 200-day bins is compatible with a steady emission with a probability of 7.3 × 10{sup –2}. A correlated analysis with Fermi-LAT data over ∼4.5 yr using the light curves of the two experiments gives a Pearson correlation coefficient r = 0.56 ± 0.22. Concerning flux variations on timescales of days, a ''blind'' search for flares with a duration of 1-15 days gives no excess with a significance higher than four standard deviations. The average rate measured by ARGO-YBJ during the three most powerful flares detected by Fermi-LAT is 205 ± 91 photons day{sup –1}, consistent with the average value of 137 ± 10 day{sup –1}.« less

Two-digit number comparison: Decade-unit and unit-decade produce the same compatibility effect with number words.

PubMed

Macizo, Pedro; Herrera, Amparo

2010-03-01

This study explored the processing of 2-digit number words by examining the unit-decade compatibility effect in Spanish. Participants were required to choose the larger of 2-digit number words presented in verbal notation. In compatible trials the decade and unit comparisons led to the same response (e.g., 53-68) while in incompatible trials the decade and unit comparisons led to different responses (e.g., 59-74). Participants were slower on compatible trials as compared to incompatible trials. In Experiments 2 and 3, we evaluated whether the reverse compatibility effect in Spanish was only due to a pure left-to-right encoding which favours the decade processing in this language (decade-unit order). When participants processed 2-digit number words presented in reverse form (in the unit-decade order), the same reverse compatibility effect was found. This pattern of results suggests that participants have learnt a language-dependent process for analysing written numbers which is used irrespective of the specific arrangement of units and decades in the comparison task. 2010 APA, all rights reserved.

75 FR 38026 - Medicare Program; Identification of Backward Compatible Version of Adopted Standard for E...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... Programs (NCPDP) Prescriber/ Pharmacist Interface SCRIPT standard, Implementation Guide, Version 10... Prescriber/Pharmacist Interface SCRIPT standard, Version 8, Release 1 and its equivalent NCPDP Prescriber/Pharmacist Interface SCRIPT Implementation Guide, Version 8, Release 1 (hereinafter referred to as the...

ION COMPOSITION ELUCIDATION (ICE): A HIGH ...

EPA Pesticide Factsheets

Identifying compounds found in the environment without knowledge of their origin is a very difficult analytical problem. Comparison of the low resolution mass spectrum of a compound with those in the NIST or Wiley mass spectral libraries can provide a tentative identification when the mass spectrum is free of interferences, at least several prominent ions are observed in the mass spectrum, the mass spectrum is in the library, and only one plausible match is found. Because these libraries contain only 226,334 distinct compounds (1) compared to the 16 million compounds that have been synthesized or isolated from natural sources (2), most compounds are not found in the libraries. In addition, most compounds are ionic, too polar, too thermolabile, or too high in mass to traverse a GC column or to volatilize from a probe. For these compounds, liquid sample introduction with electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI) provides few fragment ions for pattern matching, and adduct ions complicate the mass spectra. Commercial ESI and APCI mass spectral libraries are not available. Consequently, low resolution mass spectrometry cannot identify most compounds-. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various research projects being performed in support

Reparo de aneurisma de artéria ilíaca roto em criança

PubMed Central

Hoshiko, Fernando Massaru; Zampieri, Elisa Helena Subtil; Dalio, Marcelo Bellini; Dezotti, Nei Rodrigues Alves; Joviliano, Edwaldo Edner

2017-01-01

Resumo Relatamos o caso de uma menina de 12 anos que deu entrada na unidade de emergência com quadro de abdome agudo hemorrágico, massa abdominal pulsátil e instabilidade hemodinâmica. Confirmado o diagnóstico de aneurisma roto de artéria ilíaca direita, foi realizada correção cirúrgica de emergência por reparo aberto com reconstrução extra-anatômica, utilizando enxerto sintético de fino calibre, compatível com a anatomia. O tratamento foi bem-sucedido e a criança apresentou evolução favorável em curto prazo.

Development of smart bridge bearings system : a feasibility study : final report.

DOT National Transportation Integrated Search

2005-12-01

The goal of this project has been achieved through three tasks. The main goal of Task I has been : to identify appropriate sensors that have potential for bridge bearings applications. This has been : achieved through the following subtasks and has b...

Multi-Attribute Task Battery - Applications in pilot workload and strategic behavior research

NASA Technical Reports Server (NTRS)

Arnegard, Ruth J.; Comstock, J. R., Jr.

1991-01-01

The Multi-Attribute Task (MAT) Battery provides a benchmark set of tasks for use in a wide range of lab studies of operator performance and workload. The battery incorporates tasks analogous to activities that aircraft crewmembers perform in flight, while providing a high degree of experimenter control, performance data on each subtask, and freedom to nonpilot test subjects. Features not found in existing computer based tasks include an auditory communication task (to simulate Air Traffic Control communication), a resource management task permitting many avenues or strategies of maintaining target performance, a scheduling window which gives the operator information about future task demands, and the option of manual or automated control of tasks. Performance data are generated for each subtask. In addition, the task battery may be paused and onscreen workload rating scales presented to the subject. The MAT Battery requires a desktop computer with color graphics. The communication task requires a serial link to a second desktop computer with a voice synthesizer or digitizer card.

The multi-attribute task battery for human operator workload and strategic behavior research

NASA Technical Reports Server (NTRS)

Comstock, J. Raymond, Jr.; Arnegard, Ruth J.

1992-01-01

The Multi-Attribute Task (MAT) Battery provides a benchmark set of tasks for use in a wide range of lab studies of operator performance and workload. The battery incorporates tasks analogous to activities that aircraft crewmembers perform in flight, while providing a high degree of experimenter control, performance data on each subtask, and freedom to use nonpilot test subjects. Features not found in existing computer based tasks include an auditory communication task (to simulate Air Traffic Control communication), a resource management task permitting many avenues or strategies of maintaining target performance, a scheduling window which gives the operator information about future task demands, and the option of manual or automated control of tasks. Performance data are generated for each subtask. In addition, the task battery may be paused and onscreen workload rating scales presented to the subject. The MAT Battery requires a desktop computer with color graphics. The communication task requires a serial link to a second desktop computer with a voice synthesizer or digitizer card.

Bi-Level Integrated System Synthesis (BLISS) for Concurrent and Distributed Processing

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, Jaroslaw; Altus, Troy D.; Phillips, Matthew; Sandusky, Robert

2002-01-01

The paper introduces a new version of the Bi-Level Integrated System Synthesis (BLISS) methods intended for optimization of engineering systems conducted by distributed specialty groups working concurrently and using a multiprocessor computing environment. The method decomposes the overall optimization task into subtasks associated with disciplines or subsystems where the local design variables are numerous and a single, system-level optimization whose design variables are relatively few. The subtasks are fully autonomous as to their inner operations and decision making. Their purpose is to eliminate the local design variables and generate a wide spectrum of feasible designs whose behavior is represented by Response Surfaces to be accessed by a system-level optimization. It is shown that, if the problem is convex, the solution of the decomposed problem is the same as that obtained without decomposition. A simplified example of an aircraft design shows the method working as intended. The paper includes a discussion of the method merits and demerits and recommendations for further research.

Feasibility of flywheel energy storage systems for applications in future space missions

NASA Technical Reports Server (NTRS)

Santo, G. Espiritu; Gill, S. P.; Kotas, J. F.; Paschall, R.

1995-01-01

The objective of this study was to examine the overall feasibility of deploying electromechanical flywheel systems in space used for excess energy storage. Results of previous Rocketdyne studies have shown that the flywheel concept has a number of advantages over the NiH2 battery, including higher specific energy, longer life and high roundtrip efficiency. Based on this prior work, this current study was broken into four subtasks. The first subtask investigated the feasibility of replacing the NiH2 battery orbital replacement unit (ORU) on the international space station (ISSA) with a flywheel ORU. In addition, a conceptual design of a generic flywheel demonstrator experiment implemented on the ISSA was completed. An assessment of the life cycle cost benefits of replacing the station battery energy storage ORU's with flywheel ORU's was performed. A fourth task generated a top-level development plan for critical flywheel technologies, the flywheel demonstrator experiments and its evolution into the production unit flywheel replacement ORU.

Simulation verification techniques study: Simulation self test hardware design and techniques report

NASA Technical Reports Server (NTRS)

1974-01-01

The final results are presented of the hardware verification task. The basic objectives of the various subtasks are reviewed along with the ground rules under which the overall task was conducted and which impacted the approach taken in deriving techniques for hardware self test. The results of the first subtask and the definition of simulation hardware are presented. The hardware definition is based primarily on a brief review of the simulator configurations anticipated for the shuttle training program. The results of the survey of current self test techniques are presented. The data sources that were considered in the search for current techniques are reviewed, and results of the survey are presented in terms of the specific types of tests that are of interest for training simulator applications. Specifically, these types of tests are readiness tests, fault isolation tests and incipient fault detection techniques. The most applicable techniques were structured into software flows that are then referenced in discussions of techniques for specific subsystems.

NRA8-21 Cycle 2 RBCC Turbopump Risk Reduction

NASA Technical Reports Server (NTRS)

Ferguson, Thomas V.; Williams, Morgan; Marcu, Bogdan

2004-01-01

This project was composed of three sub-tasks. The objective of the first task was to use the CFD code INS3D to generate both on- and off-design predictions for the consortium optimized impeller flowfield. The results of the flow simulations are given in the first section. The objective of the second task was to construct a turbomachinery testing database comprised of measurements made on several different impellers, an inducer and a diffuser. The data was in the form of static pressure measurements as well as laser velocimeter measurements of velocities and flow angles within the stated components. Several databases with this information were created for these components. The third subtask objective was two-fold: first, to validate the Enigma CFD code for pump diffuser analysis, and secondly, to perform steady and unsteady analyses on some wide flow range diffuser concepts using Enigma. The code was validated using the consortium optimized impeller database and then applied to two different concepts for wide flow diffusers.

Biomechanics of normal and pathological gait: implications for understanding human locomotor control.

PubMed

Winter, D A

1989-12-01

The biomechanical (kinetic) analysis of human gait reveals the integrated and detailed motor patterns that are essential in pinpointing the abnormal patterns in pathological gait. In a similar manner, these motor patterns (moments, powers, and EMGs) can be used to identify synergies and to validate theories of CNS control. Based on kinetic and EMG patterns for a wide range of normal subjects and cadences, evidence is presented that both supports and negates the central pattern generator theory of locomotion. Adaptive motor patterns that are evident in peripheral gait pathologies reinforce a strong peripheral rather than a central control. Finally, a three-component subtask theory of human gait is presented and is supported by reference to the motor patterns seen in a normal gait. The identified subtasks are (a) support (against collapse during stance); (b) dynamic balance of the upper body, also during stance; and (c) feedforward control of the foot trajectory to achieve safe ground clearance and a gentle heel contact.

36 CFR 1193.51 - Compatibility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... BOARD TELECOMMUNICATIONS ACT ACCESSIBILITY GUIDELINES Requirements for Compatibility With Peripheral... user to easily turn any microphone on and off to allow the user to intermix speech with TTY use. (e...

36 CFR 1193.51 - Compatibility.

Code of Federal Regulations, 2011 CFR

2011-07-01

... BOARD TELECOMMUNICATIONS ACT ACCESSIBILITY GUIDELINES Requirements for Compatibility With Peripheral... user to easily turn any microphone on and off to allow the user to intermix speech with TTY use. (e...

The characterisation and design improvement of a paper-based E.coli impedimetric sensor

NASA Astrophysics Data System (ADS)

Bezuidenhout, P.; Kumar, S.; Wiederoder, M.; Schoeman, J.; Land, K.; Joubert, T.-H.

2016-02-01

This paper describes the development and optimisation of a paper-based E. coli impedimetric biosensor for water quality monitoring. Impedimetric biosensing is advantageous because it is a highly sensitive, label-free, real-time method for the detection of biological species. An impedimetric biosensor measures the change in impedance caused by specific capture of a target on the sensor surface. Each biosensor consists of a pair of photo paper-based inkjet printed electrodes. An impedance analyser was used to measure the impedance at frequencies ranging from 1 kHz to 1 MHz at 1V. The parameters that were investigated to achieve enhanced sensor performance were buffer type, antibody attachment method, measurement frequency, electrode layout, and conductive material. A 0.04M PBS (phosphate buffered saline) solution achieves better results compared to a less conductive 0.04M PB (potassium phosphate dibasic) solution. The direct adsorption of anti-E. coli antibodies onto the sensor surface yielded better results than attaching the sensor to a lateral flow test. The resistive component had a greater impact on the detected impedance, therefore an optimal frequency of 1 MHz was identified. Geometrical electrode designs that maximise the resistive change between the electrodes were utilised. Both lower cost silver and bio-compatible gold ink were validated as electrode materials. The impedance change generated by the selective capture of E. coli K-12, ranging in concentration from 103 to 107 colony forming units per millilitre (cfu/ml), showed a detection limit of 105 cfu/ml.

Tandem catalysis for the production of alkyl lactates from ketohexoses at moderate temperatures

DOE PAGES

Orazov, Marat; Davis, Mark E.

2015-09-08

Retro-aldol reactions have been implicated as the limiting steps in catalytic routes to convert biomass-derived hexoses and pentoses into valuable C2, C3, and C4 products such as glycolic acid, lactic acid, 2-hydroxy-3-butenoic acid, 2,4-dihydroxybutanoic acid, and alkyl esters thereof. Due to a lack of efficient retro-aldol catalysts, most previous investigations of catalytic pathways involving these reactions were conducted at high temperatures (≥160 °C). Here, we report moderate-temperature (around 100 °C) retro-aldol reactions of various hexoses in aqueous and alcoholic media with catalysts traditionally known for their capacity to catalyze 1,2-intramolecular carbon shift (1,2-CS) reactions of aldoses, i.e., various molybdenum oxidemore » and molybdate species, nickel(II) diamine complexes, alkali-exchanged stannosilicate molecular sieves, and amorphous TiO2–SiO2 coprecipitates. Solid Lewis acid cocatalysts that are known to catalyze 1,2-intramolecular hydride shift (1,2-HS) reactions that enable the formation of α-hydroxy carboxylic acids from tetroses, trioses, and glycolaldehyde, but cannot readily catalyze retro-aldol reactions of hexoses and pentoses at these moderate temperatures, are shown to be compatible with the aforementioned retro-aldol catalysts. The combination of a distinct retro-aldol catalyst with a 1,2-HS catalyst enables lactic acid and alkyl lactate formation from ketohexoses at moderate temperatures (around 100 °C), with yields comparable to best-reported chemocatalytic examples at high temperature conditions (≥160 °C). The use of moderate temperatures enables numerous desirable features such as lower pressure and significantly less catalyst deactivation.« less

ERD WATERSHED AND WATER QUALITY MODEL DEVELOPMENT AND TECHNICAL SUPPORT PROGRAM

EPA Science Inventory

The ERD has a long history in providing model research and development and technical support to Regions, States and the Office of Water for watersheds/water quality ecosystem research. The ERD efforts are described in major subtasks comprising the Program. Briefly, these are:

Budgeting-Based Organization of Internal Control

ERIC Educational Resources Information Center

Rogulenko, Tatiana; Ponomareva, Svetlana; Bodiaco, Anna; Mironenko, Valentina; Zelenov, Vladimir

2016-01-01

The article suggests methodical approaches to the budgeting-based organization of internal control, determines the tasks and subtasks of control that consist in the construction of an efficient system for the making, implementation, control, and analysis of managerial decisions. The organization of responsibility centers by means of implementing…

Long-term monitoring of experimental features, subtask 2 : Alexandria-Ashland highway (KY 9) pavement performance monitoring

DOT National Transportation Integrated Search

2000-06-01

Construction on the AA Highway began in late 1985 and was completed in late 1990. Prior to construction, 30 different test sections had been designed into the highway for evaluation. The test sections contain 23 different characteristic qualities and...

Programmer's guide for the GNAT computer program (numerical analysis of stratification in supercritical oxygen)

NASA Technical Reports Server (NTRS)

Heinmiller, J. P.

1971-01-01

This document is the programmer's guide for the GNAT computer program developed under MSC/TRW Task 705-2, Apollo cryogenic storage system analysis, subtask 2, is reported. Detailed logic flow charts and compiled program listings are provided for all program elements.

FORMATION OF NITRO MUSK ADDUCTS OF RAINBOW ...

EPA Pesticide Factsheets

The high use of nitro musk xylene (MX) and musk ketone (MK) as fragrances, and their persistence and bioaccumulation potential make them ubiquitous environmental contaminants. The 4-amino-MX (AMX) and 2-amino-MK (AMK) metabolites have been detected in trout fish hemoglobin (Hb) samples by gas chromatography-ion trap-mass spectrometry (GC-MS). Twelve Hb samples prepared from rainbow trout that were exposed to MX and MK, over a period of 24 and 72 h, were analyzed. Amino metabolites were liberated by basic hydrolysis and extracted from the fish Hb into n-hexane. The extract was concentrated, analyzed, and spiked with a standard solution (80 pg/uL) of AMX or AMK and reanalyzed. Concentrations of AMX from 10 to 24.7 ng/g were detected in Hb from fish taken 24 and 72 h after MX exposure. At 24 and 72 h after MK exposure, the concentration of AMK was found to be 25.1 to 51, and 9.5 to 25.1 ng/g, respectively. Concentrations of AMK in Hb from two of the three trout were substantially lower after 72 h compared with 24 h exposure. The AMX and AMK metabolites were not detected in four control samples. Average recoveries exceeding 89 and 86% could be achieved for AMX and AMK, respectively, with a coefficient of variation (CV) around 5%. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Quality. Located In the subtasks are the various r

Combined distemper-adenoviral pneumonia in a dog

PubMed Central

Rodriguez-Tovar, Luis E.; Ramírez-Romero, Rafael; Valdez-Nava, Yazel; Nevárez-Garza, Alicia M.; Zárate-Ramos, Juan J.; López, Alfonso

2007-01-01

A 3 1/2-month-old pug with oculonasal discharge and seizures was submitted for postmortem examination. Grossly, the lungs had cranioventral consolidation, and microscopically, 2 distinct types of inclusion bodies compatible with Canine distemper virus and Canine adenovirus type 2. Presence of both viruses was confirmed via immunohistochemical staining. PMID:17616064

Distinct colonization patterns and cDNA-AFLP transcriptome profiles in compatible and incompatible interactions between melon and different races of Fusarium oxysporum f. sp. melonis

PubMed Central

2011-01-01

Background Fusarium oxysporum f. sp. melonis Snyd. & Hans. (FOM) causes Fusarium wilt, the most important infectious disease of melon (Cucumis melo L.). The four known races of this pathogen can be distinguished only by infection on appropriate cultivars. No molecular tools are available that can discriminate among the races, and the molecular basis of compatibility and disease progression are poorly understood. Resistance to races 1 and 2 is controlled by a single dominant gene, whereas only partial polygenic resistance to race 1,2 has been described. We carried out a large-scale cDNA-AFLP analysis to identify host genes potentially related to resistance and susceptibility as well as fungal genes associated with the infection process. At the same time, a systematic reisolation procedure on infected stems allowed us to monitor fungal colonization in compatible and incompatible host-pathogen combinations. Results Melon plants (cv. Charentais Fom-2), which are susceptible to race 1,2 and resistant to race 1, were artificially infected with a race 1 strain of FOM or one of two race 1,2 w strains. Host colonization of stems was assessed at 1, 2, 4, 8, 14, 16, 18 and 21 days post inoculation (dpi), and the fungus was reisolated from infected plants. Markedly different colonization patterns were observed in compatible and incompatible host-pathogen combinations. Five time points from the symptomless early stage (2 dpi) to obvious wilting symptoms (21 dpi) were considered for cDNA-AFLP analysis. After successful sequencing of 627 transcript-derived fragments (TDFs) differentially expressed in infected plants, homology searching retrieved 305 melon transcripts, 195 FOM transcripts expressed in planta and 127 orphan TDFs. RNA samples from FOM colonies of the three strains grown in vitro were also included in the analysis to facilitate the detection of in planta-specific transcripts and to identify TDFs differentially expressed among races/strains. Conclusion Our data suggest that resistance against FOM in melon involves only limited transcriptional changes, and that wilting symptoms could derive, at least partially, from an active plant response. We discuss the pathogen-derived transcripts expressed in planta during the infection process and potentially related to virulence functions, as well as transcripts that are differentially expressed between the two FOM races grown in vitro. These transcripts provide candidate sequences that can be further tested for their ability to distinguish between races. Sequence data from this article have been deposited in GenBank, Accession Numbers: HO867279-HO867981. PMID:21338485

Spectroscopic metrology for isotope composition measurements and transfer standards

NASA Astrophysics Data System (ADS)

Anyangwe Nwaboh, Javis; Balslev-Harder, David; Kääriäinen, Teemu; Richmond, Craig; Manninen, Albert; Mohn, Joachim; Kiseleva, Maria; Petersen, Jan C.; Werhahn, Olav; Ebert, Volker

2017-04-01

The World Meteorological Organization (WMO) has identified greenhouse gases such as CO2, CH4 and N2O as critical for global climate monitoring. Other molecules such as CO that has an indirect effect of enhancing global warming are also monitored. WMO has stated compatibility goals for atmospheric concentration and isotope ratio measurements of these gases, e.g. 0.1 ppm for CO2 concentration measurements in the northern hemisphere and 0.01 ‰ for δ13C-CO2. For measurements of the concentration of greenhouse gases, gas analysers are typically calibrated with static gas standards e.g. traceable to the WMO scale or to the International System of Units (SI) through a national metrology institute. However, concentrations of target components, e.g. CO, in static gas standards have been observed to drift, and typically the gas matrix as well as the isotopic composition of the target component does not always reflect field gas composition, leading to deviations of the analyser response, even after calibration. The deviations are dependent on the measurement technique. To address this issue, part of the HIGHGAS (Metrology for high-impact greenhouse gases) project [1] focused on the development of optical transfer standards (OTSs) for greenhouse gases, e.g. CO2 and CO, potentially complementing gas standards. Isotope ratio mass spectrometry (IRMS) [2] is currently used to provide state-of-the-art high precision (in the 0.01 ‰ range) measurements for the isotopic composition of greenhouse gases. However, there is a need for field-deployable techniques such as optical isotope ratio spectroscopy (OIRS) that can be combined with metrological measurement methods. Within the HIGHGAS project, OIRS methods and procedures based on e.g. cavity enhanced spectroscopy (CES) and tunable diode laser absorption spectroscopy (TDLAS), matched to metrological principles have been established for the measurement of 13C/12C and 18O/16O ratios in CO2, 15N/14N ratios in N2O, and 13C/12C and 2H/1H ratios in CH4. Here, based on HIGHGAS project results, we present OTSs for atmospheric CO2 and CO measurements. The results delivered by the OTSs are in excellent agreement with gravimetric values of metrological "primary" static gas standards. The repeatabilities of the OTS results are matching the compatibility goals stated by WMO for atmospheric CO2 and CO measurements. In addition, we present OIRS measurement methods and procedures to demonstrate their applicability and validation. The requirements on, e.g. absorption line data quality and temperature sensitivity of isotope ratio, are discussed. Uncertainty budgets are presented and the traceability of the results is addressed. The current limitations in our measurements are discussed and steps taken to address these limitations are presented. Acknowledgement Parts of this work have been carried out within the European Metrology Research Programme (EMRP) ENV52 project-HIGHGAS. The EMRP is jointly funded by the EMRP participating countries within EURAMET and the European Union. References [1] EMRP project ENV52-HIGHGAS, available at: http://www.euramet.org/ [2] Prosenjit Ghosh, Willi A. Brand, International Journal of Mass Spectrometry 228, 1-33 (2003).

Blends of polyester ionomers with polar polymers: Interactions, reactions, and compatibilization

NASA Astrophysics Data System (ADS)

Boykin, Timothy Lamar

The compatibility of amorphous and semicrystalline polyester ionomers with various polar polymers (i.e., polyesters and polyamides) has been investigated for their potential use as minor component compatibilizers. The degree of compatibility (i.e., ranging from incompatible to miscible) between the polyester ionomers and the polar polymers was determined by evaluating the effect of blend composition on the melting behavior and phase behavior of binary blends. In addition, the origin of compatibility and/or incompatibility for each of the binary blends (i.e., polyamide/ionomer and polyester/ionomer) was determined by evaluating blends prepared by both solution and melt mixed methods. Subsequent to investigation of the binary blends, the effect of polyester ionomer addition on the compatibility of polyamide/polyester blends was investigated by evaluating the mechanical properties and phase morphology of ionomer compatibilized polyamide/polyester blends. Polyester ionomers (amorphous and semicrystalline) were shown to exhibit a high degree of compatibility (even miscibility) with polyamides, such as nylon 6,6 (N66). Compatibility was attributed to specific interactions between the metal counterion of the polyester ionomer and the amide groups of N66. The degree of compatibility (or miscibility) was shown to be dependent on the counterion type of the ionomer, with the highest degree exhibited by blends containing the divalent form of the polyester ionomers. Although polyester ionomers were shown to exhibit incompatibility with both poly(ethylene terephthalate) (PET) and poly(butylene terephthalate) (PBT), increasing the time of melt processing significantly enhanced the compatibility of the polyester ionomers with both PET and PBT. The observed enhancement in compatibility was attributed to ester-ester interchange between the polyester blend components, which was confirmed by NMR spectroscopy. The addition of polyester ionomers as a minor component compatibilizer (i.e., 2 to 5 wt%) resulted in significant enhancement in the impact strength and a dramatic improvement in the tensile properties compared to uncompatibilized blends of nylon 6,6 (N66) with poly(butylene terephthalate) (PBT). This behavior was attributed to an increase in the interfacial adhesion between the phase-separated domains due to strong interactions between the polyester ionomer and N66. The placement of the ionomer compatibilizer at the N66/PBT interface was facilitated by pre-extrusion of the polyester ionomer with PBT, prior to extrusion with N66.

CRISPR/Cas9-mediated knockout of PiSSK1 reveals essential role of S-locus F-box protein-containing SCF complexes in recognition of non-self S-RNases during cross-compatible pollination in self-incompatible Petunia inflata.

PubMed

Sun, Linhan; Kao, Teh-Hui

2018-06-01

Function of Petunia PiSSK1. Self-incompatibility (SI), an inbreeding-preventing mechanism, is regulated in Petunia inflata by the polymorphic S-locus, which houses multiple pollen-specific S-locus F-box (SLF) genes and a single pistil-specific S-RNase gene. S 2 -haplotype and S 3 -haplotype possess the same 17 polymorphic SLF genes (named SLF1 to SLF17), and each SLF protein produced in pollen is assembled into an SCF (Skp1-Cullin1-F-box) E3 ubiquitin ligase complex. A complete suite of SLF proteins is thought to collectively interact with all non-self S-RNases to mediate their ubiquitination and degradation by the 26S proteasome, allowing cross-compatible pollination. For each SCF SLF complex, the Cullin1 subunit (named PiCUL1-P) and Skp1 subunit (named PiSSK1), like the F-box protein subunits (SLFs), are pollen-specific, raising the possibility that they also evolved specifically to function in SI. Here we used CRISPR/Cas9-meditated genome editing to generate frame-shift indel mutations in PiSSK1 and examined the SI behavior of a T 0 plant (S 2 S 3 ) with biallelic mutations in the pollen genome and two progeny plants (S 2 S 2 ) each homozygous for one of the indel alleles and not carrying the Cas9-containing T-DNA. Their pollen was completely incompatible with pistils of seven otherwise-compatible S-genotypes, but fully compatible with pistils of an S 3 S 3 transgenic plant in which production of S 3 -RNase was completely suppressed by an antisense S 3 -RNase gene, and with pistils of immature flower buds, which produce little S-RNase. These results suggest that PiSSK1 specifically functions in SI and support the hypothesis that SLF-containing SCF complexes are essential for compatible pollination.

Future satellite systems - Market demand assessment

NASA Technical Reports Server (NTRS)

Reiner, P. S.

1981-01-01

During 1979-80, a market study was performed regarding the future total demand for communications services, and satellite transmission service at the 4/6 GHz, 12/14 GHz, and 20/30 GHz frequencies. Included in the study were a variety of communications traffic characteristics as well as projections of the cost of C and Ku band satellite systems through the year 2000. In connection with the considered study, a total of 15 major study tasks and subtasks were undertaken and were all interrelated in various ways. The telecommunications service forecasts were concerned with a total of 21 data services, 5 voice services, and 5 video services. The traffic volumes within the U.S. for the three basic services were projected for three time periods. It is found that the fixed frequency allocation for domestic satellites combined with potential interference from adjacent satellites means a near term lack of orbital positions above the U.S.

Visual feature integration and focused attention: response competition from multiple distractor features.

PubMed

Lavie, N

1997-05-01

Predictions from Treisman's feature integration theory of attention were tested in a variant of the response-competition paradigm. Subjects made choice responses to particular color-shape conjunctions (e.g., a purple cross vs. a green circle) while withholding their responses to the opposite conjunctions (i.e., a purple circle vs. a green cross). The results showed that compatibility effects were based on both distractor color and shape. For unattended distractors in preknown irrelevant positions, compatibility effects were equivalent for conjunctive distractors (e.g., a purple cross and a blue triangle) and for disjunctive distractors (e.g., a purple triangle and a blue cross). Manipulation of attention to the distractors positions resulted in larger compatibility effects from conjoined features. These results accord with Treisman's claim that correct conjunction information is unavailable under conditions of inattention, and they provide new information on response-competition effects from multiple features.

Generic Skills for Occupational Training.

ERIC Educational Resources Information Center

Smith, Arthur De W.

Generic skills are those overt and covert behaviors which are fundamental to the performance of many tasks and subtasks carried out in a wide range of occupations and which are basic to both specialized applications and job specific skills. They consist of academic, reasoning, interpersonal and manipulation skills. The generic approach is…

ANALYSIS OF LOW-LEVEL PESTICIDES FROM HIGH-ELEVATION LAKE WATERS BY LARGE VOLUME INJECTION GCMS

EPA Science Inventory

This paper describes the method development for the determination of ultra-low level pesticides from high-elevation lake waters by large-volume injection programmable temperature vaporizer (LVI-PTV) GC/MS. This analytical method is developed as a subtask of a larger study, backgr...

48 CFR 307.7108 - Statement of work.

Code of Federal Regulations, 2010 CFR

2010-10-01

... projects frequently lie well beyond the present state of the art and entail procedures and techniques of... for guidance on preparation of a PWS. An SOW may include tasks and subtasks. The degree of breakout... degree of expertise. (6) Special requirements (as applicable). This includes providing, in a separate...

Applying AI to the Writer's Learning Environment.

ERIC Educational Resources Information Center

Houlette, Forrest

1991-01-01

Discussion of current applications of artificial intelligence (AI) to writing focuses on how to represent knowledge of the writing process in a way that links procedural knowledge to other types of knowledge. A model is proposed that integrates the subtasks of writing into the process of writing itself. (15 references) (LRW)

An Action Sequence Withheld in Memory Can Delay Execution of Visually Guided Actions: The Generalization of Response Compatibility Interference

ERIC Educational Resources Information Center

Wiediger, Matthew D.; Fournier, Lisa R.

2008-01-01

Withholding an action plan in memory for later execution can delay execution of another action, if the actions share a similar (compatible) action feature (i.e., response hand). This phenomenon, termed compatibility interference (CI), was found for identity-based actions that do not require visual guidance. The authors examined whether CI can…

String universality in ten dimensions.

PubMed

Adams, Allan; Taylor, Washington; Dewolfe, Oliver

2010-08-13

We show that the N=1 supergravity theories in ten dimensions with gauge groups U(1){496} and E{8}×U(1){248} are not consistent quantum theories. Cancellation of anomalies cannot be made compatible with supersymmetry and Abelian gauge invariance. Thus, in ten dimensions all supersymmetric theories of gravity without known inconsistencies are realized in string theory.

Slip localization on the southern Alpine Fault, New Zealand

NASA Astrophysics Data System (ADS)

Barth, N. C.; Boulton, C.; Carpenter, B. M.; Batt, G. E.; Toy, V. G.

2013-06-01

of a detailed field study of the southern onshore portion of New Zealand's Alpine Fault reveal that for 75 km along-strike, dextral-normal slip on this long-lived structure is highly localized in phyllosilicate-rich fault core gouges and along their contact with more competent rocks. At three localities (Martyr River, McKenzie Creek, and Hokuri Creek), we document complete cross sections through the fault. New 40Ar/39Ar dates on mylonites, combined with microstructural and mechanical data on phyllosilicate-rich fault core gouges show that modern slip is localized onto a single, steeply dipping 1 to 12 m-thick fault core composed of impermeable (k = 10-20 to 10-22 m2), frictionally weak (μs = 0.12-0.37), velocity-strengthening, illite-chlorite, and saponite-chlorite-lizardite fault gouges. Fault core materials are (1) comparable to those of other major weak-cored faults (e.g., San Andreas Fault) and (2) most compatible with fault creep, despite paleoseismic evidence of quasiperiodic large magnitude earthquakes (Mw > 7) on this portion of the Alpine Fault. We conclude that frictional properties of gouges at the surface do not characterize the overall seismogenic behavior of the southern Alpine Fault.

Toward a Cognitive Task Analysis for Biomedical Query Mediation

PubMed Central

Hruby, Gregory W.; Cimino, James J.; Patel, Vimla; Weng, Chunhua

2014-01-01

In many institutions, data analysts use a Biomedical Query Mediation (BQM) process to facilitate data access for medical researchers. However, understanding of the BQM process is limited in the literature. To bridge this gap, we performed the initial steps of a cognitive task analysis using 31 BQM instances conducted between one analyst and 22 researchers in one academic department. We identified five top-level tasks, i.e., clarify research statement, explain clinical process, identify related data elements, locate EHR data element, and end BQM with either a database query or unmet, infeasible information needs, and 10 sub-tasks. We evaluated the BQM task model with seven data analysts from different clinical research institutions. Evaluators found all the tasks completely or semi-valid. This study contributes initial knowledge towards the development of a generalizable cognitive task representation for BQM. PMID:25954589

Toward a cognitive task analysis for biomedical query mediation.

PubMed

Hruby, Gregory W; Cimino, James J; Patel, Vimla; Weng, Chunhua

2014-01-01

In many institutions, data analysts use a Biomedical Query Mediation (BQM) process to facilitate data access for medical researchers. However, understanding of the BQM process is limited in the literature. To bridge this gap, we performed the initial steps of a cognitive task analysis using 31 BQM instances conducted between one analyst and 22 researchers in one academic department. We identified five top-level tasks, i.e., clarify research statement, explain clinical process, identify related data elements, locate EHR data element, and end BQM with either a database query or unmet, infeasible information needs, and 10 sub-tasks. We evaluated the BQM task model with seven data analysts from different clinical research institutions. Evaluators found all the tasks completely or semi-valid. This study contributes initial knowledge towards the development of a generalizable cognitive task representation for BQM.

Detailed analysis of the Japanese version of the Rapid Dementia Screening Test, revised version.

PubMed

Moriyama, Yasushi; Yoshino, Aihide; Muramatsu, Taro; Mimura, Masaru

2017-11-01

The number-transcoding task on the Japanese version of the Rapid Dementia Screening Test (RDST-J) requires mutual conversion between Arabic and Chinese numerals (209 to , 4054 to , to 681, to 2027). In this task, question and answer styles of Chinese numerals are written horizontally. We investigated the impact of changing the task so that Chinese numerals are written vertically. Subjects were 211 patients with very mild to severe Alzheimer's disease and 42 normal controls. Mini-Mental State Examination scores ranged from 26 to 12, and Clinical Dementia Rating scores ranged from 0.5 to 3. Scores of all four subtasks of the transcoding task significantly improved in the revised version compared with the original version. The sensitivity and specificity of total scores ≥9 on the RDST-J original and revised versions for discriminating between controls and subjects with Clinical Dementia Rating scores of 0.5 were 63.8% and 76.6% on the original and 60.1% and 85.8% on revised version. The revised RDST-J total score had low sensitivity and high specificity compared with the original RDST-J for discriminating subjects with Clinical Dementia Rating scores of 0.5 from controls. © 2017 Japanese Psychogeriatric Society.

Mapping of the Bak, Tang, and Wiesenfeld sandpile model on a two-dimensional Ising-correlated percolation lattice to the two-dimensional self-avoiding random walk

NASA Astrophysics Data System (ADS)

Cheraghalizadeh, J.; Najafi, M. N.; Dashti-Naserabadi, H.; Mohammadzadeh, H.

2017-11-01

The self-organized criticality on the random fractal networks has many motivations, like the movement pattern of fluid in the porous media. In addition to the randomness, introducing correlation between the neighboring portions of the porous media has some nontrivial effects. In this paper, we consider the Ising-like interactions between the active sites as the simplest method to bring correlations in the porous media, and we investigate the statistics of the BTW model in it. These correlations are controlled by the artificial "temperature" T and the sign of the Ising coupling. Based on our numerical results, we propose that at the Ising critical temperature Tc the model is compatible with the universality class of two-dimensional (2D) self-avoiding walk (SAW). Especially the fractal dimension of the loops, which are defined as the external frontier of the avalanches, is very close to DfSAW=4/3 . Also, the corresponding open curves has conformal invariance with the root-mean-square distance Rrms˜t3 /4 (t being the parametrization of the curve) in accordance with the 2D SAW. In the finite-size study, we observe that at T =Tc the model has some aspects compatible with the 2D BTW model (e.g., the 1 /log(L ) -dependence of the exponents of the distribution functions) and some in accordance with the Ising model (e.g., the 1 /L -dependence of the fractal dimensions). The finite-size scaling theory is tested and shown to be fulfilled for all statistical observables in T =Tc . In the off-critical temperatures in the close vicinity of Tc the exponents show some additional power-law behaviors in terms of T -Tc with some exponents that are reported in the text. The spanning cluster probability at the critical temperature also scales with L1/2, which is different from the regular 2D BTW model.

Expression and localization of members of the thrombospondin family during final follicle maturation and corpus luteum formation and function in the bovine ovary

PubMed Central

BERISHA, Bajram; SCHAMS, Dieter; RODLER, Daniela; SINOWATZ, Fred; PFAFFL, Michael W.

2016-01-01

The aim of this study was to characterize the expression patterns and localization of the thrombospondin family members (THBS1, THBS2) and their receptors (CD36 and CD47) in bovine ovaries. First, the antral follicles were classified into 5 groups based on the follicle size and estradiol-17beta (E2) concentration in the follicular fluid (< 0.5, 0.5–5, 5–40, 40–180 and >180 E2 ng/ml). Second, the corpus luteum (CL) was assigned to the following stages: days 1–2, 3–4, 5–7, 8–12, 13–16 and >18 of the estrous cycle and of pregnancy (month 1–2, 3–4, 6–7 and > 8). Third, the corpora lutea were collected by transvaginal ovariectomy before and 0.5, 2, 4, 12, 24, 48 and 64 h after inducing luteolysis by injecting a prostaglandin F2alpha analog. The mRNA expression of examined factors was measured by RT-qPCR, steroid hormone concentration by EIA, and localization by immunohistochemistry. The mRNA expression of THBS1, THBS2, CD36, and CD47 in the granulosa cells and theca interna was high in the small follicles and reduced in the preovulatory follicles. The mRNA expression of THBS1, THBS2, and CD47 in the CL during the estrous cycle was high, but decreased significantly during pregnancy. After induced luteolysis, thrombospondins increased significantly to reach the maximum level at 12 h for THBS1, 24 h for THBS2, and 48 h for CD36. The temporal expression and localization pattern of the thrombospondins and their specific receptors in the antral follicles and corpora lutea during the different physiological phases of the estrous cycle and induced luteolysis appear to be compatible with their inhibitory role in the control of ovarian angiogenesis. PMID:27396384

Asymmetrically Functionalized Graphene for Photodependent Diode Rectifying Behavior

DTIC Science & Technology

2011-06-06

catalysts for oxygen reduction in fuel cells, high-performance electrodes in supercapacitors , batteries, actuators, and sen- sors.[1,2] Of particular...Stoller et al.[1j] produced graphene-based supercapacitors free from any conducting filler with a specific capacitance of 135 Fg1 in aqueous electrolytes...dimensionally compatible and electrically conduc- tive component, Guo et al.[2g,h] further constructed a smart graphene-based multifunctional biointerface for

COATING ALTERNATIVES GUIDE (CAGE) USER'S GUIDE

EPA Science Inventory

The guide provides instructions for using the Coating Alternatives GuidE (CAGE) software program, version 1.0. It assumes that the user is familiar with the fundamentals of operating an IBM-compatible personal computer (PC) under the Microsoft disk operating system (MS-DOS). CAGE...

Evaluation of Aeroservoelastic Effects on Flutter

NASA Technical Reports Server (NTRS)

Nagaraja, K. S.; Felt, Larry R.; Kraft, Raymond

1998-01-01

This report presents work performed by The Boeing Company to satisfy the deliverable "Evaluation of aeroservoelastic Effects on Symmetric Flutter" for Subtask 7 of Reference 1. The objective of this report is to incorporate the improved methods for studying the effects of a closed-loop control system on the aeroservoelastic behavior of the airplane planned under NASA HSR technical Integration Task 20 work. Also, a preliminary evaluation of the existing pitch control laws on symmetric flutter of the TCA configuration was addressed."The goal is to develop an improved modeling methodology and perform design studies that account for the aero-structures-systems interaction effects.

Design and development of integral heat pipe/thermal energy storage devices. [used with spacecraft cryocoolers

NASA Technical Reports Server (NTRS)

Mahefkey, E. T.; Richter, R.

1981-01-01

The major design and performance test subtasks in the development of small (200 to 1,000 whr) integral heat pipe/thermal energy storage devices for use with thermally driven spacecraft cryo-coolers are described. The design of the integral heat pipe/thermal energy storage device was based on a quasi steady resistance heat transfer, lumped capacitance model. Design considerations for the heat pipe and thermal storage annuli are presented. The thermomechanical stress and insulation system design for the device are reviewed. Experimental correlations are described, as are the plans for the further development of the concept.

Design and development of integral heat pipe/thermal energy storage devices

NASA Astrophysics Data System (ADS)

Mahefkey, E. T.; Richter, R.

1981-06-01

The major design and performance test subtasks in the development of small (200 to 1,000 whr) integral heat pipe/thermal energy storage devices for use with thermally driven spacecraft cryo-coolers are described. The design of the integral heat pipe/thermal energy storage device was based on a quasi steady resistance heat transfer, lumped capacitance model. Design considerations for the heat pipe and thermal storage annuli are presented. The thermomechanical stress and insulation system design for the device are reviewed. Experimental correlations are described, as are the plans for the further development of the concept.

Formal Assurance Certifiable Tooling Formal Assurance Certifiable Tooling Strategy Final Report

NASA Technical Reports Server (NTRS)

Bush, Eric; Oglesby, David; Bhatt, Devesh; Murugesan, Anitha; Engstrom, Eric; Mueller, Joe; Pelican, Michael

2017-01-01

This is the Final Report of a research project to investigate issues and provide guidance for the qualification of formal methods tools under the DO-330 qualification process. It consisted of three major subtasks spread over two years: 1) an assessment of theoretical soundness issues that may affect qualification for three categories of formal methods tools, 2) a case study simulating the DO-330 qualification of two actual tool sets, and 3) an investigation of risk mitigation strategies that might be applied to chains of such formal methods tools in order to increase confidence in their certification of airborne software.

Multidimensional Time Dependent Structure and Mechanisms for Non-LTE CO2 Infrared Emissions and 4.3 Micrometers Aurora.

DTIC Science & Technology

1979-08-31

fields V Z) measured by tracking a TMA release on the 3/23/73 date by Faire and Bettinger (private communication, 1976) are shown on Figure B2. The S 0(aN...CONTRACT OR GRANT NUMBER(s) J_~ B.7umer ____ 9 PERFORMING ORGANIZATION NAME AND ADDRESS I0. PROGRAM ELEMENT. PROJECT. TASK AREA A WORK UNIT NUMBERS...Defense Nuclear Agency (DNA) under Subtask T25AAXHZ639, Work Unit 04 entitled "IR Data Evaluation". * OORS ’C-nrine on rel-erse .,doe .1- - a .,rv a , I

Low-cost spray-processed Ag{sub 1−x}Cu{sub x}InS{sub 2} nano-films: Structural and functional investigation within the Lattice Compatibility Theory framework

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gherouel, D.; Yumak, A.; Znaidi, M.

Highlights: • Cu{sub x}Ag{sub 1−x}InS{sub 2} with a minimal lattice mismatch between absorbers and buffers. • The lattice compatibility for understanding silver–copper kinetics. • Controlled and enhanced spray pyrolisis method as a low-cost synthesis protocol. - Abstract: This work deals with some structural and optical investigations about Cu{sub x}Ag{sub 1−x}InS{sub 2} alloys sprayed films and the beneficial effect of copper incorporation in AgInS{sub 2} ternary matrices. The main purpose of this work is to obtain the band gap energy E{sub g} as well as different lattice parameters. The studied properties led to reaching minimum of lattice mismatch between absorber andmore » buffer layers within solar cell devices. As a principal and original finding, the lattice compatibility between both silver and copper indium disulfide structures has been proposed as a guide for understanding kinetics of these materials crystallization.« less

The Use of a Higher Order Kinematic Relationship on the Analysis of Cylindrical Composite Panels

DTIC Science & Technology

1991-12-01

form: exNl All A 12 A 16 B11 B12 B16 D nl D12 D16 E11 E12 E16 F11 F12 F16 COyI A12 A22 A6 B12 B22 B 1 D 2 D22 D26 E12 E2 2 E16 F1 2 F22 F26 0 A16 A 26...2 + 2E,,)kw,, ,., " kErWly + (kE11 + B 1 1)4f.,. + 2(kE 6 B16 )*.,x,, + (kE6 6 + B 616 ) *X,yy + (kE 1 6 + B 1 6 ) *y,, + [k (E1 2 + E6 6 ) " B12...B1 6 ) *x, y " (kE1 6 + B1 6 ) 1Y~ + (kE31 2 + B12) p,y, + -R-- 1 O 2 - B16 o, x + 12 W- 16W y- kF12 W, y - Wk16 + D6 x x-a W k 12 + D1 2)4r,y, 0 auo

Expression of the 12-oxophytodienoic acid 10,11-reductase gene in the compatible interaction between pea and fungal pathogen.

PubMed

Ishiga, Yasuhiro; Funato, Akiko; Tachiki, Tomoyuki; Toyoda, Kazuhiro; Shiraishi, Tomonori; Yamada, Tetsuji; Ichinose, Yuki

2002-10-01

Suppressors produced by Mycosphaerella pinodes are glycopeptides to block pea defense responses induced by elicitors. A clone, S64, was isolated as cDNA for suppressor-inducible gene from pea epicotyls. The treatment of pea epicotyls with suppressor alone induced an increase of S64 mRNA within 1 h, and it reached a maximum level at 3 h after treatment. The induction was not affected by application of the elicitor, indicating that the suppressor has a dominant action to regulate S64 gene expression. S64 was also induced by inoculation with a virulent pathogen, M. pinodes, but not by inoculation with a non-pathogen, Ascochyta rabiei, nor by treatment with fungal elicitor. The deduced structure of S64 showed high homology to 12-oxophytodienoic acid reductase (OPR) in Arabidopsis thaliana. A recombinant protein derived from S64 had OPR activity, suggesting compatibility-specific activation of the octadecanoid pathway in plants. Treatment with jasmonic acid (JA) or methyl jasmonic acid, end products of the octadecanoid pathway, inhibited the elicitor-induced accumulation of PAL mRNA in pea. These results indicate that the suppressor-induced S64 gene expression leads to the production of JA or related compounds, which might contribute to the establishment of compatibility by inhibiting the phenylpropanoid biosynthetic pathway.

Testing a model of componential processing of multi-symbol numbers-evidence from measurement units.

PubMed

Huber, Stefan; Bahnmueller, Julia; Klein, Elise; Moeller, Korbinian

2015-10-01

Research on numerical cognition has addressed the processing of nonsymbolic quantities and symbolic digits extensively. However, magnitude processing of measurement units is still a neglected topic in numerical cognition research. Hence, we investigated the processing of measurement units to evaluate whether typical effects of multi-digit number processing such as the compatibility effect, the string length congruity effect, and the distance effect are also present for measurement units. In three experiments, participants had to single out the larger one of two physical quantities (e.g., lengths). In Experiment 1, the compatibility of number and measurement unit (compatible: 3 mm_6 cm with 3 < 6 and mm < cm; incompatible: 3 cm_6 mm with 3 < 6 but cm > mm) as well as string length congruity (congruent: 1 m_2 km with m < km and 2 < 3 characters; incongruent: 2 mm_1 m with mm < m, but 3 > 2 characters) were manipulated. We observed reliable compatibility effects with prolonged reaction times (RT) for incompatible trials. Moreover, a string length congruity effect was present in RT with longer RT for incongruent trials. Experiments 2 and 3 served as control experiments showing that compatibility effects persist when controlling for holistic distance and that a distance effect for measurement units exists. Our findings indicate that numbers and measurement units are processed in a componential manner and thus highlight that processing characteristics of multi-digit numbers generalize to measurement units. Thereby, our data lend further support to the recently proposed generalized model of componential multi-symbol number processing.

Image quality associated with the use of an MR-compatible incubator in neonatal neuroimaging.

PubMed

O'Regan, K; Filan, P; Pandit, N; Maher, M; Fanning, N

2012-04-01

MRI in the neonate poses significant challenges associated with patient transport and monitoring, and the potential for diminished image quality owing to patient motion. The objective of this study was to evaluate the usefulness of a dedicated MR-compatible incubator with integrated radiofrequency coils in improving image quality of MRI studies of the brain acquired in term and preterm neonates using standard MRI equipment. Subjective and objective analyses of image quality of neonatal brain MR examinations were performed before and after the introduction of an MR-compatible incubator. For all studies, the signal-to-noise ratio (SNR) was calculated, image quality was graded (1-3) and each was assessed for image artefact (e.g. motion). Student's t-test and the Mann-Whitney U-test were used to compare mean SNR values. 39 patients were included [mean gestational age 39 weeks (range 30-42 weeks); mean postnatal age 13 days (range 1-56 days); mean weight 3.5 kg (range 1.4-4.5 kg)]. Following the introduction of the MR-compatible incubator, diagnostic quality scans increased from 50 to 89% and motion artefact decreased from 73 to 44% of studies. SNR did not increase initially, but, when using MR sequences and parameters specifically tailored for neonatal brain imaging, SNR increased from 70 to 213 (p=0.001). Use of an MR-compatible incubator in neonatal neuroimaging provides a safe environment for MRI of the neonate and also facilitates patient monitoring and transport. When specifically tailored MR protocols are used, this results in improved image quality.

76 FR 4880 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-27

... (December 5, 2006); (12) MSPB/GOVT-1: Appeals and Case Records, 67 FR 70254 (November 21, 2002); (13) OGE... case EAC determines that the disclosure is compatible with the purpose for which the records were... 300, Washington, DC 20005. In the case where an individual believes EAC maintains records pertaining...

Over-expression of FT1 in plum (Prunus domestica) results in phenotypes compatible with spaceflight: a potential new candidate crop for bioregenerative life support systems

USDA-ARS?s Scientific Manuscript database

Tree fruits (e.g., apples, plums, cherries) are appealing constituents of a crew menu for long-duration exploration missions (i.e., Mars), both in terms of their nutritive and menu diversity contributions. Although appealing, tree fruit species have long been precluded as candidate crops for use in...

Histological long-term outcomes from acute antibody-mediated rejection following ABO-compatible liver transplantation.

PubMed

Del Bello, Arnaud; Danjoux, Marie; Congy-Jolivet, Nicolas; Lavayssière, Laurence; Esposito, Laure; Muscari, Fabrice; Kamar, Nassim

2017-04-01

Acute antibody-mediated rejection (aAMR) is an unusual complication after orthotopic ABO-compatible liver transplantation. To date, the clinical and histological long-term outcomes after aAMR are not well known. Herein, we describe nine cases of aAMR that occurred in our liver-transplant center between 2008 and 2016, with an initial and reevaluation liver biopsy available for reexamination. Two patients presented with aAMR at 10.5 (10, 11) days post-transplantation, caused by preformed donor-specific antibodies. Seven other recipients developed de novo donor-specific antibodies and aAMR at 11.2 (3-24) months post-transplantation. Eight of the nine patients received a B-cell targeting agent (rituximab, with or without plasma exchange), associated with polyclonal antibodies (three patients) or intravenous immunoglobulins (three patients). At the last follow up (i.e. 21 [4-90] months post-aAMR), seven patients were alive, including two patients with normal liver tests. Grafts' survival was 66%. A liver biopsy performed at 11.5 (5-48.5) months after the first biopsy showed no significant improvement in aAMR score (from 2 ± 1.3 to 1.6 ± 1.5, P = 0.6), a significant improvement in chronic AMR score (from 37 ± 9 to 25 ± 8, P = 0.003) and an increase in the Metavir score (1.2 ± 0.6 to 2.1 ± 0.9, P = 0.03). In this study, a B-cell-depleting agent seemed to improve the prognosis of aAMR in selected cases, but several patients kept active lesions antibody-mediated rejection. © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

Implementation and assessment of an animal management system for small-animal micro-CT / micro-SPECT imaging

NASA Astrophysics Data System (ADS)

Holdsworth, David W.; Detombe, Sarah A.; Chiodo, Chris; Fricke, Stanley T.; Drangova, Maria

2011-03-01

Advances in laboratory imaging systems for CT, SPECT, MRI, and PET facilitate routine micro-imaging during pre-clinical investigations. Challenges still arise when dealing with immune-compromised animals, biohazardous agents, and multi-modality imaging. These challenges can be overcome with an appropriate animal management system (AMS), with the capability for supporting and monitoring a rat or mouse during micro-imaging. We report the implementation and assessment of a new AMS system for mice (PRA-3000 / AHS-2750, ASI Instruments, Warren MI), designed to be compatible with a commercial micro-CT / micro-SPECT imaging system (eXplore speCZT, GE Healthcare, London ON). The AMS was assessed under the following criteria: 1) compatibility with the imaging system (i.e. artifact generation, geometric dimensions); 2) compatibility with live animals (i.e. positioning, temperature regulation, anesthetic supply); 3) monitoring capabilities (i.e. rectal temperature, respiratory and cardiac monitoring); 4) stability of co-registration; and 5) containment. Micro-CT scans performed using a standardized live-animal protocol (90 kVp, 40 mA, 900 views, 16 ms per view) exhibited low noise (+/-19 HU) and acceptable artifact from high-density components within the AMS (e.g. ECG pad contacts). Live mice were imaged repeatedly (with removal and replacement of the AMS) and spatial registration was found to be stable to within +/-0.07 mm. All animals tolerated enclosure within the AMS for extended periods (i.e. > one hour) without distress, based on continuous recordings of rectal temperature, ECG waveform and respiratory rate. A sealed AMS system extends the capability of a conventional micro-imaging system to include immune-compromised and biosafety level 2 mouse-imaging protocols.

Fabrication, Quality Assurance, and Quality Control for PROSPECT Detector Component Production

NASA Astrophysics Data System (ADS)

Gustafson, Ian; Prospect (The Precision Reactor Oscillation; Spectrum Experiment) Collaboration

2017-09-01

The Precision Reactor Oscillation and Spectrum Experiment (PROSPECT) is an electron antineutrino (νe) detector intended to make a precision measurement of the 235U neutrino spectrum and to search for the possible existence of sterile neutrinos with a mass splitting of Δm2 on the order of 1 eV2 . As a short baseline detector, PROSPECT will be located less than 10 meters from the High Flux Isotope Reactor at Oak Ridge National Laboratory. As PROSPECT intends to search for baseline-dependent oscillations, physical segmentation is needed to better measure the interaction position. PROSPECT will therefore be a segmented detector in two dimensions, thereby improving position measurements. PROSPECT will be segmented into 154 (11×14) 1.2-meter long rectangular tubes, using optical separators. Each separator will consist of a carbon fiber core, laminated with optical reflector (to increase light collection) and Teflon (to ensure compatibility with the scintillator). These optical separators will be held in place via strings of 3D printed PLA rods called `pinwheels.' This poster discusses the fabrication and quality assurance (QA) procedures used in the production of both the PROSPECT optical separators and pinwheels. For the PROSPECT collaboration.

Patterns of Reproductive Isolation in Eucalyptus-A Phylogenetic Perspective.

PubMed

Larcombe, Matthew J; Holland, Barbara; Steane, Dorothy A; Jones, Rebecca C; Nicolle, Dean; Vaillancourt, René E; Potts, Brad M

2015-07-01

We assess phylogenetic patterns of hybridization in the speciose, ecologically and economically important genus Eucalyptus, in order to better understand the evolution of reproductive isolation. Eucalyptus globulus pollen was applied to 99 eucalypt species, mainly from the large commercially important subgenus, Symphyomyrtus. In the 64 species that produce seeds, hybrid compatibility was assessed at two stages, hybrid-production (at approximately 1 month) and hybrid-survival (at 9 months), and compared with phylogenies based on 8,350 genome-wide DArT (diversity arrays technology) markers. Model fitting was used to assess the relationship between compatibility and genetic distance, and whether or not the strength of incompatibility "snowballs" with divergence. There was a decline in compatibility with increasing genetic distance between species. Hybridization was common within two closely related clades (one including E. globulus), but rare between E. globulus and species in two phylogenetically distant clades. Of three alternative models tested (linear, slowdown, and snowball), we found consistent support for a snowball model, indicating that the strength of incompatibility accelerates relative to genetic distance. Although we can only speculate about the genetic basis of this pattern, it is consistent with a Dobzhansky-Muller-model prediction that incompatibilities should snowball with divergence due to negative epistasis. Different rates of compatibility decline in the hybrid-production and hybrid-survival measures suggest that early-acting postmating barriers developed first and are stronger than later-acting barriers. We estimated that complete reproductive isolation can take up to 21-31 My in Eucalyptus. Practical implications for hybrid eucalypt breeding and genetic risk assessment in Australia are discussed. © The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Development of RP UPLC-TOF/MS, stability indicating method for omeprazole and its related substances by applying two level factorial design; and identification and synthesis of non-pharmacopoeial impurities.

PubMed

Jadhav, Sushant Bhimrao; Kumar, C Kiran; Bandichhor, Rakeshwar; Bhosale, P N

2016-01-25

A new UPLC-TOF/MS compatible, reverse phase-stability indicating method was developed for determination of Omeprazole (OMP) and its related substances in pharmaceutical dosage forms by implementing Design of Experiment (DoE) i.e. two level full factorial Design (2(3)+3 center points=11 experiments) to understand the Critical Method Parameters (CMP) and its relation with Critical Method Attribute (CMA); to ensure robustness of the method. The separation of eleven specified impurities including conversion product of OMP related compound F (13) and G (14) i.e. Impurity-I (1), OMP related compound-I (11) and OMP 4-chloro analog (12) was achieved in a single method on Acquity BEH shield RP18 100 × 2.1 mm, 1.7 μm column, with inlet filter (0.2 μm) using gradient elution and detector wavelength at 305 nm and validated in accordance with ICH guidelines and found to be accurate, precise, reproducible, robust and specific. The drug was found to degrade extensively in heat, humidity and acidic conditions and forms unknown degradation products during stability studies. The same method was used for LC-MS analysis to identify m/z and fragmentation of maximum unknown impurities (Non-Pharmacopoeial) i.e. Impurity-I (1), Impurity-III (3), Impurity-V (5) and Impurity-VIII (9) formed during stability studies. Based on the results, degradation pathway for the drug has been proposed and synthesis of identified impurities i.e. impurities (Impurity-I (1), Impurity-III (3), Impurity-V (5) and Impurity-VIII (9)) are discussed in detail to ensure in-depth understanding of OMP and its related impurities and optimum performance during lifetime of the product. Copyright © 2015. Published by Elsevier B.V.

Euparyphium albuferensis and Echinostoma friedi (Trematoda: Echinostomatidae): experimental cercarial transmission success in sympatric snail communities.

PubMed

Muñoz-Antoli, Carla; Marin, Antoni; Vidal, Amparo; Toledo, Rafael; Esteban, José Guillermo

2008-06-01

Euparyphium albuferensis and Echinostoma friedi cercarial infectivity to four species of sympatric snails was examined under single- or multiple-choice laboratory conditions to show the level of parasite-snail host compatibility. Radix peregra, Lymnaeafuscus, Physella acuta and Gyraulus chinensis act as second intermediate hosts of both parasite species although different cercarial transmission success (CTS) was observed. In single-host experiments, R. peregra and P. acuta showed a high degree of compatibility with E. albuferensis, while only P. acuta in the case of E. friedi. In two-choice snail communities, a snail with high CTS increased the values of another with low compatibility, in both parasite species. In multiple-choice snail communities, high CTS of some hosts decreased, while low CTS of other hosts increased. The degree of parasite-host compatibility of each snail species could be determined by the presence of other snails in the community.

CD-REST: a system for extracting chemical-induced disease relation in literature.

PubMed

Xu, Jun; Wu, Yonghui; Zhang, Yaoyun; Wang, Jingqi; Lee, Hee-Jin; Xu, Hua

2016-01-01

Mining chemical-induced disease relations embedded in the vast biomedical literature could facilitate a wide range of computational biomedical applications, such as pharmacovigilance. The BioCreative V organized a Chemical Disease Relation (CDR) Track regarding chemical-induced disease relation extraction from biomedical literature in 2015. We participated in all subtasks of this challenge. In this article, we present our participation system Chemical Disease Relation Extraction SysTem (CD-REST), an end-to-end system for extracting chemical-induced disease relations in biomedical literature. CD-REST consists of two main components: (1) a chemical and disease named entity recognition and normalization module, which employs the Conditional Random Fields algorithm for entity recognition and a Vector Space Model-based approach for normalization; and (2) a relation extraction module that classifies both sentence-level and document-level candidate drug-disease pairs by support vector machines. Our system achieved the best performance on the chemical-induced disease relation extraction subtask in the BioCreative V CDR Track, demonstrating the effectiveness of our proposed machine learning-based approaches for automatic extraction of chemical-induced disease relations in biomedical literature. The CD-REST system provides web services using HTTP POST request. The web services can be accessed fromhttp://clinicalnlptool.com/cdr The online CD-REST demonstration system is available athttp://clinicalnlptool.com/cdr/cdr.html. Database URL:http://clinicalnlptool.com/cdr;http://clinicalnlptool.com/cdr/cdr.html. © The Author(s) 2016. Published by Oxford University Press.

A Unique β-1,2-Mannosyltransferase of Thermotoga maritima That Uses Di-myo-Inositol Phosphate as the Mannosyl Acceptor▿

PubMed Central

Rodrigues, Marta V.; Borges, Nuno; Almeida, Carla P.; Lamosa, Pedro; Santos, Helena

2009-01-01

In addition to di-myo-inositol-1,3′-phosphate (DIP), a compatible solute widespread in hyperthermophiles, the organic solute pool of Thermotoga maritima comprises 2-(O-β-d-mannosyl)-di-myo-inositol-1,3′-phosphate (MDIP) and 2-(O-β-d-mannosyl-1,2-O-β-d-mannosyl)-di-myo-inositol-1,3′-phosphate (MMDIP), two newly identified β-1,2-mannosides. In cells grown under heat stress, MDIP was the major solute, accounting for 43% of the total pool; MMDIP and DIP accumulated to similar levels, each corresponding to 11.5% of the total pool. The synthesis of MDIP involved the transfer of the mannosyl group from GDP-mannose to DIP in a single-step reaction catalyzed by MDIP synthase. This enzyme used MDIP as an acceptor of a second mannose residue, yielding the di-mannosylated compound. Minor amounts of the tri-mannosylated form were also detected. With a genomic approach, putative genes for MDIP synthase were identified in the genome of T. maritima, and the assignment was confirmed by functional expression in Escherichia coli. Genes with significant sequence identity were found only in the genomes of Thermotoga spp., Aquifex aeolicus, and Archaeoglobus profundus. MDIP synthase of T. maritima had maximal activity at 95°C and apparent Km values of 16 mM and 0.7 mM for DIP and GDP-mannose, respectively. The stereochemistry of MDIP was characterized by isotopic labeling and nuclear magnetic resonance (NMR): DIP selectively labeled with carbon 13 at position C1 of the l-inositol moiety was synthesized and used as a substrate for MDIP synthase. This β-1,2-mannosyltransferase is unrelated to known glycosyltransferases, and within the domain Bacteria, it is restricted to members of the two deepest lineages, i.e., the Thermotogales and the Aquificales. To our knowledge, this is the first β-1,2-mannosyltransferase characterized thus far. PMID:19648237

Dissociative adsorption of environment-friendly insulating medium C3F7CN on Cu(111) and Al(111) surface: A theoretical evaluation

NASA Astrophysics Data System (ADS)

Zhang, Xiaoxing; Li, Yi; Chen, Dachang; Xiao, Song; Tian, Shuangshuang; Tang, Ju; Wang, Dibo

2018-03-01

SF6 is extensively used in electrical applications because of its excellent insulation and arc extinguishing performance, but its strong greenhouse effect has negative impact on the atmosphere. The excellent performance of C3F7CN in greenhouse effect, insulation ability, safety, and thermal stability has been demonstrated, indicating that this compound can replace SF6 in electrical applications. However, little information is available on the compatibility of C3F7CN with metals, such as copper and aluminum, in devices. Material compatibility between new gas mixtures and materials used in Gas Insulated Switchgear (GIS) should be investigated to determine the long-term behavior of materials. In this paper, dissociative adsorption of C3F7CN on Cu (1 1 1) and Al (1 1 1) surfaces were analyzed based on density functional theory. Adsorption energy, charge transfer, density of states, and electron density difference of interaction between C3F7CN and two metals were analyzed. It was found that the adsorption energy of C3F7CN adsorbed on Cu (1 1 1) and Al (1 1 1) is both below 0.8 eV. This value indicates that the interaction between them is not very strong. In addition, the dissociation reaction path of gas molecules after adsorption requires certain activation energy. Therefore, C3F7CN and copper or aluminum have certain compatibility and the compatibility of C3F7CN with aluminum is better than that of copper. Related results provide a reference for predicting the aging mechanism of equipment and the selection or modification of major materials for equipment.

Water-Compatible Polymer Concrete Materials for use in Rapid Repair Systems for Airport Runways

DTIC Science & Technology

1981-03-01

resin systems, resorcinol phenol- formaldehyde (RPF), urea - formaldehyde (UF), melamine - formaldehyde (MF), and furfuryl alcohol (FA), were selected for...type polymer systems. Phenol- formaldehyde (PF), melamine - formaldehyde (MF), urea -formalde- hyde (UF), and furfuryl alcohol (FA) monomers contain OH and...1-1.5) (1-2) Urea - formaldehyde NH2 CONH2 - HCHO Liquid 7150 (1.0) (1.5-2.5) Melamine - formaldehyde NH2 C:NC(NH2 ):NC(N’H2

Tank 241-U-103, grab samples 3U-99-1, 3u-99-2 and 3U-99-3

DOE Office of Scientific and Technical Information (OSTI.GOV)

STEEN, F.H.

This document is the final report for tank 241-U-103 grab samples. Three grab samples were collected from riser 13 on March 12, 1999 and received by the 222-S laboratory on March 15, 1999. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan for Fiscal year 1999 (TSAP) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO). The analytical results are presented in the data summary report. None of the subsamples submitted for differential scanning calorimetry (DSC), total organic carbon (TOC) and plutonium 239 (Pu239) analyses exceeded the notification limits as stated in TSAP.

Effect Anticipation Affects Perceptual, Cognitive, and Motor Phases of Response Preparation: Evidence from an Event-Related Potential (ERP) Study

PubMed Central

Harrison, Neil R.; Ziessler, Michael

2016-01-01

The anticipation of action effects is a basic process that can be observed even for key-pressing responses in a stimulus-response paradigm. In Ziessler et al.’s (2012) experiments participants first learned arbitrary effects of key-pressing responses. In the test phase an imperative stimulus determined the response, but participants withheld the response until a Go-stimulus appeared. Reaction times (RTs) were shorter if the Go-stimulus was compatible with the learned response effect. This is strong evidence that effect representations were activated during response planning. Here, we repeated the experiment using event-related potentials (ERPs), and we found that Go-stimulus locked ERPs depended on the compatibility relationship between the Go-stimulus and the response effect. In general, this supports the interpretation of the behavioral data. More specifically, differences in the ERPs between compatible and incompatible Go-stimuli were found for the early perceptual P1 component and the later frontal P2 component. P1 differences were found only in the second half of the experiment and for long stimulus onset asynchronies (SOAs) between imperative stimulus and Go-stimulus, i.e., when the effect was fully anticipated and the perceptual system was prepared for the effect-compatible Go-stimulus. P2 amplitudes, likely associated with evaluation and conflict detection, were larger when Go-stimulus and effect were incompatible; presumably, incompatibility increased the difficulty of effect anticipation. Onset of response-locked lateralized readiness potentials (R-LRPs) occurred earlier under incompatible conditions indicating extended motor processing. Together, these results strongly suggest that effect anticipation affects all (i.e., perceptual, cognitive, and motor) phases of response preparation. PMID:26858621

Effect Anticipation Affects Perceptual, Cognitive, and Motor Phases of Response Preparation: Evidence from an Event-Related Potential (ERP) Study.

PubMed

Harrison, Neil R; Ziessler, Michael

2016-01-01

The anticipation of action effects is a basic process that can be observed even for key-pressing responses in a stimulus-response paradigm. In Ziessler et al.'s (2012) experiments participants first learned arbitrary effects of key-pressing responses. In the test phase an imperative stimulus determined the response, but participants withheld the response until a Go-stimulus appeared. Reaction times (RTs) were shorter if the Go-stimulus was compatible with the learned response effect. This is strong evidence that effect representations were activated during response planning. Here, we repeated the experiment using event-related potentials (ERPs), and we found that Go-stimulus locked ERPs depended on the compatibility relationship between the Go-stimulus and the response effect. In general, this supports the interpretation of the behavioral data. More specifically, differences in the ERPs between compatible and incompatible Go-stimuli were found for the early perceptual P1 component and the later frontal P2 component. P1 differences were found only in the second half of the experiment and for long stimulus onset asynchronies (SOAs) between imperative stimulus and Go-stimulus, i.e., when the effect was fully anticipated and the perceptual system was prepared for the effect-compatible Go-stimulus. P2 amplitudes, likely associated with evaluation and conflict detection, were larger when Go-stimulus and effect were incompatible; presumably, incompatibility increased the difficulty of effect anticipation. Onset of response-locked lateralized readiness potentials (R-LRPs) occurred earlier under incompatible conditions indicating extended motor processing. Together, these results strongly suggest that effect anticipation affects all (i.e., perceptual, cognitive, and motor) phases of response preparation.

Engineering and Physics Optimization of Breed and Burn Fast Reactor Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michael J. Driscoll; Pavel Hejzlar; Peter Yarsky

2005-12-09

This project is organized under four major tasks (each of which has two or more subtasks) with contributions among the three collaborating organizations (MIT, INEEL and ANL-West): Task A: Core Physics and Fuel Cycle; Task B: Core Thermal Hydraulics; Task C: Plant Design Task; and D: Fuel Design.

Hierarchically Organized Behavior and Its Neural Foundations: A Reinforcement Learning Perspective

ERIC Educational Resources Information Center

Botvinick, Matthew M.; Niv, Yael; Barto, Andrew C.

2009-01-01

Research on human and animal behavior has long emphasized its hierarchical structure--the divisibility of ongoing behavior into discrete tasks, which are comprised of subtask sequences, which in turn are built of simple actions. The hierarchical structure of behavior has also been of enduring interest within neuroscience, where it has been widely…

An experimental distributed microprocessor implementation with a shared memory communications and control medium

NASA Technical Reports Server (NTRS)

Mejzak, R. S.

1980-01-01

The distributed processing concept is defined in terms of control primitives, variables, and structures and their use in performing a decomposed discrete Fourier transform (DET) application function. The design assumes interprocessor communications to be anonymous. In this scheme, all processors can access an entire common database by employing control primitives. Access to selected areas within the common database is random, enforced by a hardware lock, and determined by task and subtask pointers. This enables the number of processors to be varied in the configuration without any modifications to the control structure. Decompositional elements of the DFT application function in terms of tasks and subtasks are also described. The experimental hardware configuration consists of IMSAI 8080 chassis which are independent, 8 bit microcomputer units. These chassis are linked together to form a multiple processing system by means of a shared memory facility. This facility consists of hardware which provides a bus structure to enable up to six microcomputers to be interconnected. It provides polling and arbitration logic so that only one processor has access to shared memory at any one time.

Advanced in-duct sorbent injection for SO{sub 2} control. Topical report No. 2, Subtask 2.2: Design optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenhoover, W.A.; Stouffer, M.R.; Withum, J.A.

1994-12-01

The objective of this research project is to develop second-generation duct injection technology as a cost-effective SO{sub 2} control option for the 1990 Clean Air Act Amendments. Research is focused on the Advanced Coolside process, which has shown the potential for achieving the performance targets of 90% SO{sub 2} removal and 60% sorbent utilization. In Subtask 2.2, Design Optimization, process improvement was sought by optimizing sorbent recycle and by optimizing process equipment for reduced cost. The pilot plant recycle testing showed that 90% SO{sub 2} removal could be achieved at sorbent utilizations up to 75%. This testing also showed thatmore » the Advanced Coolside process has the potential to achieve very high removal efficiency (90 to greater than 99%). Two alternative contactor designs were developed, tested and optimized through pilot plant testing; the improved designs will reduce process costs significantly, while maintaining operability and performance essential to the process. Also, sorbent recycle handling equipment was optimized to reduce cost.« less

An evaluation of nursing tasks.

PubMed

Baptiste, Andrea

2011-01-01

Functional capacity evaluations have been criticized as being too general in theory and not being accurate enough to determine what tasks an employee can perform. This paper will describe results of a descriptive study that was conducted in a laboratory setting to objectively determine the physical demands of patient transfer tasks performed by nurses. Fifty three tasks were analyzed and broken down into sub-tasks to quantify the peak force required to perform each sub-task in order to determine which tasks pose healthcare workers at highest risk of injury. Dissecting the transfer task into segments allows us to see which part of the task requires high forces on the part of the caregiver. The task can then be modified to eliminate the risk of injury to the caregiver. This modification can be accomplished by using healthcare technology, such as floor based or overhead lifts, friction reducing devices, sit to stand lifts, properly designed slings, and motorized beds/trolleys. Technological solutions are available for some of these high risk tasks and should be implemented where applicable to reduce the force demand and eliminate or reduce the risk of injury to healthcare workers in nursing.

Experimental Interactions of Components of Hemodialysis Units with Human Blood

PubMed Central

Zucker, W. H.; Shinoda, B. A.; Mason, R. G.

1974-01-01

An in vitro model test system for estimation of the blood compatibility of hemodialysis membranes and tubing is described. The model test system consists of a modified hemodialysis unit and blood pump through which fresh citrated human blood is circulated. The effects of the use of different pump and tubing types upon hematologic and blood coagulation parameters are described. Preexposure of test surfaces to albumin appeared to enhance blood compatibility characteristics of the model test system, whereas preexposure to a high density lipoprotein preparation or a proteinpolysaccharide preparation was without appreciable benefit. Use of blood from subjects receiving aspirin resulted in enhanced blood compatibility in the test system as did use of heparin. Use of Warfarin or dextran did not appear to enhance blood compatibility of test surfaces under the conditions of this test system. Dialysis membranes and tubing which formed parts of the test system were examined by scanning and transmission electron microscopy in control tests and in tests for effects of proteins and antithrombotic agents. ImagesFig 5Fig 6Fig 7Fig 8Fig 9Fig 10Fig 11Fig 12Fig 13Fig 14Fig 1Fig 2Fig 3Fig 4 PMID:4825611

How to Develop Electrochemistry SETS-Based Interactive E-Book?

NASA Astrophysics Data System (ADS)

Munawwarah, M.; Anwar, S.; Sunarya, Y.

2017-09-01

This study aims to develop SETS-based interactive e-book teaching material through 4S TMD methode. The research methode in this study is the Development Research (RD) Richey and Klein that consists of design, phase, and evaluation. The design step was to analyze and plan the types of teaching materials instructional developed. There are 12 indicators from 3 standard competences that produced in selection step based new curriculum, the compatibility subject matter and indicators, and the relations between value and subject matter. Structuring steps yield concept map, macro structure, and multiple representation that were arranged to be first draft of teaching material that was used for develop the instruments for characterization step. Chatacterization test have been done to students in 12nd grades with 68 texts. Characterization results indicated that there were some texts included to difficult text. Difficult texts have been reduced with the ways back to qualitative steps and particulation. The second draft of teaching material was arranged based the results of didactic reduction of difficult texts. This draft was used for arranged interactive e-book. The characteristics of this SETS-based interactive e-book that developed were mention about the connection between science with environment, technology, and society. This interactive e-book consists of animation, task, and quizes that taken the interaction of students directly.

Recycling of plastic wastes with poly (ethylene-co-methacrylic acid) copolymer as compatibilizer and their conversion into high-end product.

PubMed

Rajasekaran, Divya; Maji, Pradip K

2018-04-01

This paper deals with the utilization of plastic wastes to a useful product. The major plastic pollutants that are considered to be in maximum use i.e. PET bottle and PE bags have been taken for consideration for recycling. As these two plastic wastes are not compatible, poly (ethylene-co-methacrylic acid) copolymer has been used as compatibilizer to process these two plastic wastes. Effect of dose of poly (ethylene-co-methacrylic acid) copolymer as compatibilizer has been studied here. It has been shown that only 3 wt% of poly (ethylene-co-methacrylic acid) copolymer is sufficient to make 3:1 mass ratio of PET bottle and polyethylene bags compatible. Compatibility has been examined through mechanical testing, thermal and morphological analysis. After analysing the property of recyclates, better mechanical and thermal property has been observed. Almost 500% of tensile property has been improved by addition of 3 wt% of poly (ethylene-co-methacrylic acid) copolymer in 3:1 mass ratio blend of PET bottle and PE bags than that of pristine blend. Morphological analysis by FESEM and AFM has also confirmed the compatibility of the blend. Experimental data showed better performance than available recycling process. Copyright © 2018 Elsevier Ltd. All rights reserved.

Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families.

PubMed

Xiong, Lan; Dion, Patrick; Montplaisir, Jacques; Levchenko, Anastasia; Thibodeau, Pascale; Karemera, Liliane; Rivière, Jean-Baptiste; St-Onge, Judith; Gaspar, Claudia; Dubé, Marie-Pierre; Desautels, Alex; Turecki, Gustavo; Rouleau, Guy A

2007-10-05

Converging evidence from clinical observations, brain imaging and pathological findings strongly indicate impaired brain iron regulation in restless legs syndrome (RLS). Animal models with mutation in (DMT1) divalent metal transporter 1 gene, an important brain iron transporter, demonstrate a similar iron deficiency profile as found in RLS brain. The human DMT1 gene, mapped to chromosome 12q near the RLS1 locus, qualifies as an excellent functional and possible positional candidate for RLS. DMT1 protein levels were assessed in lymphoblastoid cell lines from RLS patients and controls. Linkage analyses were carried out with markers flanking and within the DMT1 gene. Selected patient samples from RLS families with compatible linkage to the RLS1 locus on 12q were fully sequenced in both the coding regions and the long stretches of UTR sequences. Finally, selected sequence variants were further studied in case/control and family-based association tests. A clinical association of anemia and RLS was further confirmed in this study. There was no detectable difference in DMT1 protein levels between RLS patient lymphoblastoid cell lines and normal controls. Non-parametric linkage analyses failed to identify any significant linkage signals within the DMT1 gene region. Sequencing of selected patients did not detect any sequence variant(s) compatible with DMT1 harboring RLS causative mutation(s). Further studies did not find any association between ten SNPs, spanning the whole DMT1 gene region, and RLS affection status. Finally, two DMT1 intronic SNPs showed positive association with RLS in patients with a history of anemia, when compared to RLS patients without anemia. (c) 2007 Wiley-Liss, Inc.

The Ships Below-Decks Electromagnetic Compatibility (EMC) Program. A compilation of Papers Presented at the 1987 IEEE International Symposium on EMC

DTIC Science & Technology

1987-09-30

were producing below-deck environ - such that after 24 hours the performance loss ranged mental levels exceeding the "normal" environmental from 13 to...SGA performance environmental EMI testing in the electromagnetically measurements b- made in the laboratory. However, it quiet laboratory environments ... Environmentally Sealed SGAs.................................... 1-1 Need for Long Term SGA Performance Evaluation .................... 1-2 Performance

46 CFR Figure 1 to Part 150 - Compatibility Chart

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 5 2014-10-01 2014-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

46 CFR Figure 1 to Part 150 - Compatibility Chart

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 5 2013-10-01 2013-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

46 CFR Figure 1 to Part 150 - Compatibility Chart

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 5 2012-10-01 2012-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

46 CFR Figure 1 to Part 150 - Compatibility Chart

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

46 CFR Figure 1 to Part 150 - Compatibility Chart

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

Does Felt Gender Compatibility Mediate Influences of Self-Perceived Gender Nonconformity on Early Adolescents' Psychosocial Adjustment?

ERIC Educational Resources Information Center

Menon, Meenakshi

2011-01-01

This study evaluated the hypothesis that self-perceived gender nonconformity is distressing to children because it undermines a confident sense of gender compatibility. Participants were 357 early adolescents (180 boys, M age = 12.68 years) in England who responded to questionnaires measuring friendship styles (preoccupied, avoidant), gender…

Style-by-style analysis of two sporadic self-compatible Solanum chacoense lines supports a primary role for S-RNases in determining pollen rejection thresholds.

PubMed

Qin, Xike; Liu, Bolin; Soulard, Jonathan; Morse, David; Cappadocia, Mario

2006-01-01

A method for the quantification of S-RNase levels in single styles of self-incompatible Solanum chacoense was developed and applied toward an experimental determination of the S-RNase threshold required for pollen rejection. It was found that, when single style values are averaged, accumulated levels of the S(11)- and S(12)-RNases can differ up to 10-fold within a genotype, while accumulated levels of the S(12)-RNase can differ by over 3-fold when different genotypes are compared. Surprisingly, the amount of S(12)-RNase accumulated in different styles of the same plant can differ by over 20-fold. A low level of 160 ng S-RNase in individual styles of fully incompatible plants, and a high value of 68 ng in a sporadic self-compatible (SSC) line during a bout of complete compatibility was measured, suggesting that these values bracket the threshold level of S-RNase needed for pollen rejection. Remarkably, correlations of S-RNase values to average fruit sets in different plant lines displaying sporadic self-compatibility (SSC) to different extents as well as to fruit set in immature flowers, are all consistent with a threshold value of 80 ng S(12)-RNase. Taken together, these results suggest that S-RNase levels alone are the principal determinant of the incompatibility phenotype. Interestingly, while the S-RNase threshold required for rejection of S(12)-pollen from a given genetic background is the same in styles of different genetic backgrounds, it is different when pollen donors of different genetic backgrounds are used. These results reveal a previously unsuspected level of complexity in the incompatibility reaction.

Milliwatt Generator Project

NASA Astrophysics Data System (ADS)

Latimer, T. W.; Rinehart, G. H.

1992-05-01

This report covers progress on the Milliwatt Generator Project from April 1986 through March 1988. Activities included fuel processing and characterization, production of heat sources, fabrication of pressure-burst test units, compatibility studies, impact testing, and examination of surveillance units. The major task of the Los Alamos Milliwatt Generator Project is to fabricate MC2893A heat sources (4.0 W) for MC2730A radioisotope thermoelectric generators (RTG's) and MC3599 heat sources (4.5 W) for MC3500 RTG's. The MWG Project interfaces with the following contractors: Sandia National Laboratories, Albuquerque (designer); E.I. du Pont de Nemours and Co. (Inc.), Savannah River Plant (fuel); Monsanto Research Corporation, Mound Facility (metal hardware); and General Electric Company, Neutron Devices Department (RTG's). In addition to MWG fabrication activities, Los Alamos is involved in (1) fabrication of pressure-burst test units, (2) compatibility testing and evaluation, (3) examination of surveillance units, and (4) impact testing and subsequent examination of compatibility and surveillance units.

Reactivity of p-Toluenesulfonylmethyl Isocyanide: Iron-Involved C-H Tosylmethylation of Imidazopyridines in Nontoxic Media.

PubMed

Lu, Shuai; Zhu, Xinju; Li, Ke; Guo, Yu-Jing; Wang, Meng-Dan; Zhao, Xue-Mei; Hao, Xin-Qi; Song, Mao-Ping

2016-09-16

A novel iron-involved tosylmethylation of imidazo[1,2-α]pyridines with p-toluenesulfonylmethyl isocyanide in a solvent mixture of H2O and PEG400 under an Ar atmosphere has been developed. This protocol provides a facile synthetic route for the functionalization of the imidazo[1,2-α]pyridine scaffold with broad substrate compatibility, which is less expensive and environmentally friendly. The current methodology could further enable regioselective C-H tosylmethylation of indole at the C3 position. Also, p-toluenesulfonylmethyl isocyanide was utilized as the tosylmethylating reagent for the first time.

Anisotropic Exciton Rabi Oscillation in Single Telecommunication-Band Quantum Dot

NASA Astrophysics Data System (ADS)

Toshiyuki Miyazawa,; Toshihiro Nakaoka,; Katsuyuki Watanabe,; Naoto Kumagai,; Naoki Yokoyama,; Yasuhiko Arakawa,

2010-06-01

Anisotropic Rabi oscillation in the exciton state in a single InAs/GaAs quantum dot (QD) was demonstrated in the telecommunication-band by selecting two orthogonal polarization angles of the excitation laser. Our InAs QDs were embedded in an intrinsic layer of an n-i-Schottky diode, which provides an electric field to extract photoexcited carriers from QDs. Owing to the potential anisotropy of QDs, the fine structure splitting (FSS) energy in the exciton state in single InAs QDs was ˜110 μeV, measured by polarization-resolved photocurrent spectroscopy. The ratio between two different Rabi frequencies, which reflect anisotropic dipole moments of two orthogonal exciton states, was estimated to be ˜1.2. This demonstrates that the selective control of two orthogonal polarized exciton states is a promising technique for exciton-based-quantum information devices compatible with fiber optics.

COATING ALTERNATIVES GUIDE (CAGE) USER'S GUIDE (EPA/600/R-01/030)

EPA Science Inventory

The guide provides instructions for using the Coating Alternatives GuidE (CAGE) software program, version 1.0. It assumes that the user is familiar with the fundamentals of operating an IBM-compatible personal computer (PC) under the Microsoft disk operating system (MS-DOS). CAGE...

Avionics System Design for High Energy Fields

DTIC Science & Technology

1988-07-01

this report describes design practices which will lead to reducc electromagnetic susceptibility of avionics systems in high energy fields . A second...nuclear reactions. Tn most cases the radiation which causes electromagnetic interference Is completely harmless to humans . Many techniqteq are used in...variety of electromagnetic compatibility problems. 1,e fIrst use EMCad to preeict the field strength from a discharge. Next, we usc’e r. a second

A neural joint model for entity and relation extraction from biomedical text.

PubMed

Li, Fei; Zhang, Meishan; Fu, Guohong; Ji, Donghong

2017-03-31

Extracting biomedical entities and their relations from text has important applications on biomedical research. Previous work primarily utilized feature-based pipeline models to process this task. Many efforts need to be made on feature engineering when feature-based models are employed. Moreover, pipeline models may suffer error propagation and are not able to utilize the interactions between subtasks. Therefore, we propose a neural joint model to extract biomedical entities as well as their relations simultaneously, and it can alleviate the problems above. Our model was evaluated on two tasks, i.e., the task of extracting adverse drug events between drug and disease entities, and the task of extracting resident relations between bacteria and location entities. Compared with the state-of-the-art systems in these tasks, our model improved the F1 scores of the first task by 5.1% in entity recognition and 8.0% in relation extraction, and that of the second task by 9.2% in relation extraction. The proposed model achieves competitive performances with less work on feature engineering. We demonstrate that the model based on neural networks is effective for biomedical entity and relation extraction. In addition, parameter sharing is an alternative method for neural models to jointly process this task. Our work can facilitate the research on biomedical text mining.

[Interface compatibility between tooth-like yttria-stabilized tetragonal zirconia polycrystal by adding rare-earth oxide and Vita VM9 veneering porcelain].

PubMed

Gao, Yan; Zhang, Fu-qiang; He, Fan

2011-10-01

To evaluate the interface compatibility between tooth-like yttria-stabilized tetragonal zirconia polycrystal(Y-TZP) by adding rare-earth oxide and Vita VM9 veneering porcelain. Six kinds(S1,S2,S3,S4,S5,S6) of tooth-like yttria stabilized tetragonal zirconia polycrystal were made by introducing internal colorating technology to detect the thermal shock resistance and interface bonding strength with Vita VM9 Bsaedentin. Statistical analysis was performed using SAS6.12 software package. There was no gap between the layers via hot shocking test.The shear bonding strength between Y-TZP and VitaVM9 was higher and the value was (36.03±3.82) to (37.98±4.89) MPa. By adding rare-earth oxide to yttria-stabilized tetragonal zirconia polycrystal ,better compatibility between the layer (TZP and Vita VM9) can be formed which is of better interface integrate and available for clinical applications.

A Boron Protecting Group Strategy for 1,2-Azaborines.

PubMed

Baggett, Andrew W; Liu, Shih-Yuan

2017-10-25

Upon reaction with either molecular oxygen or di-tert-butylperoxide in the presence of a simple copper(I) salt and an alcohol, a range of 1,2-azaborines readily exchange B-alkyl or B-aryl moieties for B-alkoxide fragments. This transformation allows alkyl and aryl groups to serve for the first time as removable protecting groups for the boron position of 1,2-azaborines during reactions that are not compatible with the easily modifiable B-alkoxide moiety. This reaction can be applied to synthesize a previously inaccessible BN isostere of ethylbenzene, a compound of interest in biomedical research. A sequence of epoxide ring opening using N-deprotonated 1,2-azaborines followed by an intramolecular version of the boron deprotection reaction can be applied to access the first examples of BN isosteres of dihydrobenzofurans and benzofurans, classes of compounds that are important to medicinal chemistry and natural product synthesis.

Sequential Effects on Speeded Information Processing: A Developmental Study

ERIC Educational Resources Information Center

Smulders, S.F.A.; Notebaert, W.; Meijer, M.; Crone, E.A.; van der Molen, M.W.; Soetens, E.

2005-01-01

Two experiments were performed to assess age-related changes in sequential effects on choice reaction time (RT). Sequential effects portray the influence of previous trials on the RT to the current stimulus. In Experiment 1, three age groups (7-9, 10-12, and 18-25 years) performed a spatially compatible choice task, with response-to-stimulus…

A newly developed real-time PCR assay for detection and quantification of Fusarium oxysporum and its use in compatible and incompatible interactions with grafted melon genotypes.

PubMed

Haegi, Anita; Catalano, Valentina; Luongo, Laura; Vitale, Salvatore; Scotton, Michele; Ficcadenti, Nadia; Belisario, Alessandra

2013-08-01

A reliable and species-specific real-time quantitative polymerase chain reaction (qPCR) assay was developed for detection of the complex soilborne anamorphic fungus Fusarium oxysporum. The new primer pair, designed on the translation elongation factor 1-α gene with an amplicon of 142 bp, was highly specific to F. oxysporum without cross reactions with other Fusarium spp. The protocol was applied to grafted melon plants for the detection and quantification of F. oxysporum f. sp. melonis, a devastating pathogen of this cucurbit. Grafting technologies are widely used in melon to confer resistance against new virulent races of F. oxysporum f. sp. melonis, while maintaining the properties of valuable commercial varieties. However, the effects on the vascular pathogen colonization have not been fully investigated. Analyses were performed on 'Charentais-T' (susceptible) and 'Nad-1' (resistant) melon cultivars, both used either as rootstock and scion, and inoculated with F. oxysporum f. sp. melonis race 1 and race 1,2. Pathogen development was compared using qPCR and isolations from stem tissues. Early asymptomatic melon infections were detected with a quantification limit of 1 pg of fungal DNA. The qPCR protocol clearly showed that fungal development was highly affected by host-pathogen interaction (compatible or incompatible) and time (days postinoculation). The principal significant effect (P ≤ 0.01) on fungal development was due to the melon genotype used as rootstock, and this effect had a significant interaction with time and F. oxysporum f. sp. melonis race. In particular, the amount of race 1,2 DNA was significantly higher compared with that estimated for race 1 in the incompatible interaction at 18 days postinoculation. The two fungal races were always present in both the rootstock and scion of grafted plants in either the compatible or incompatible interaction.

Experimental evaluation of the concept of supevisory manipulation

NASA Technical Reports Server (NTRS)

Brooks, T. L.; Sheridan, T. B.

1982-01-01

A computer-controlled teleoperator system which is based on task-referenced sensor-aided control has been developed to study supervisory manipulation. This system, called SUPERMAN, is capable of performing complicated tasks in real-time by utilizing the operator for high-level functions related to the unpredictable portions of a task, while the subordinate machine performs the more well-defined subtasks under human supervison. To determine whether supervisory control schemes such as these offer any advantage over manual control under real-time conditions, a number of experiments involving both simple and complicated tasks were performed. Six representative tasks were chosen for the study: (1) obtaining a tool from a rack, (2) returning the tool to the rack, (3) removing a nut, (4) placing samples in a storage bin, (5) opening and closing a valve, and (6) digging with a shovel. The experiments were performed under simulated conditions using four forms of manual control (i.e., switch rate, joystick rate, master-slave position control, and master-slave with force feedback), as well as supervisory control. Through these experiments the effectiveness and quality of control were evaluated on the basis of the time required to complete each portion of the task and the type and number of errors which occurred.

The Stroop color-word test: influence of age, sex, and education; and normative data for a large sample across the adult age range.

PubMed

Van der Elst, Wim; Van Boxtel, Martin P J; Van Breukelen, Gerard J P; Jolles, Jelle

2006-03-01

The Stroop Color-Word Test was administered to 1,856 cognitively screened, healthy Dutch speaking participants aged 24 to 81 years. The effects of age, gender, and education on Stroop test performance were investigated to adequately stratify the normative data. The results showed that especially the speed-dependent Stroop scores (time to complete a subtest), rather than the accuracy measures (the errors made per Stroop sub-task), were profoundly affected by the demographic variables. In addition to the main effects of the demographic variables, an Age Low Level of Education interaction was found for the Error III and the Stroop Interference scores. This suggests that executive function, as measured by the Stroop test, declines with age and that the decline is more pronounced in people with a low level of education. This is consistent with the reserve hypothesis of brain aging (i.e., that education generates reserve capacity against the damaging effects of aging on brain functions). Normative Stroop data were established using both a regression-based and traditional approach, and the appropriateness of both methods for generating normative data is discussed.

46 CFR 154.467 - Submission of insulation information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... must be submitted for special approval by the Commandant (CG-522): (a) Compatibility with the cargo. (b) Solubility in the cargo. (c) Absorption of the cargo. (d) Shrinkage. (e) Aging. (f) Closed cell content. (g... installation details of the insulation including: (1) Fabrication; (2) Storage; (3) Handling; (4) Erection; and...

DNA recovery from microhymenoptera using six non-destructive methodologies with considerations for subsequent preparation of museum slides.

PubMed

Guzmán-Larralde, Adriana J; Suaste-Dzul, Alba P; Gallou, Adrien; Peña-Carrillo, Kenzy I

2017-01-01

Because of the tiny size of microhymenoptera, successful morphological identification typically requires specific mounting protocols that require time, skills, and experience. Molecular taxonomic identification is an alternative, but many DNA extraction protocols call for maceration of the whole specimen, which is not compatible with preserving museum vouchers. Thus, non-destructive DNA isolation methods are attractive alternatives for obtaining DNA without damaging sample individuals. However, their performance needs to be assessed in microhymenopterans. We evaluated six non-destructive methods: (A) DNeasy® Blood & Tissue Kit; (B) DNeasy® Blood & Tissue Kit, modified; (C) Protocol with CaCl 2 buffer; (D) Protocol with CaCl 2 buffer, modified; (E) HotSHOT; and (F) Direct PCR. The performance of each DNA extraction method was tested across several microhymenopteran species by attempting to amplify the mitochondrial gene COI from insect specimens of varying ages: 1 day, 4 months, 3 years, 12 years, and 23 years. Methods B and D allowed COI amplification in all insects, while methods A, C, and E were successful in DNA amplification from insects up to 12 years old. Method F, the fastest, was useful in insects up to 4 months old. Finally, we adapted permanent slide preparation in Canada balsam for every technique. The results reported allow for combining morphological and molecular methodologies for taxonomic studies.

Task Analysis for the Jobs of Freight Train Conductor and Brakeman. RDTR No. 263.

ERIC Educational Resources Information Center

Sanders, Mark S.; And Others

The principal tasks performed by conductors, rear brakemen, and head brakemen during over-the-road freight operations are identified and described in the report. Forty-four tasks and subtasks are analyzed and grouped into six categories: basic handling tasks, prerun preparation and starting off tasks, over-the-road tasks, terminating tasks,…

Relationships among Individual Task Self-Efficacy, Self-Regulated Learning Strategy Use and Academic Performance in a Computer-Supported Collaborative Learning Environment

ERIC Educational Resources Information Center

Wilson, Kimberly; Narayan, Anupama

2016-01-01

This study investigates relationships between self-efficacy, self-regulated learning strategy use and academic performance. Participants were 96 undergraduate students working on projects with three subtasks (idea generation task, methodical task and data collection) in a blended learning environment. Task self-efficacy was measured with…

When, What, and How Much to Reward in Reinforcement Learning-Based Models of Cognition

ERIC Educational Resources Information Center

Janssen, Christian P.; Gray, Wayne D.

2012-01-01

Reinforcement learning approaches to cognitive modeling represent task acquisition as learning to choose the sequence of steps that accomplishes the task while maximizing a reward. However, an apparently unrecognized problem for modelers is choosing when, what, and how much to reward; that is, when (the moment: end of trial, subtask, or some other…

A Task Analysis for Teaching the Organization of an Informative Speech.

ERIC Educational Resources Information Center

Parks, Arlie Muller

The purpose of this paper is to demonstrate a task analysis of the objectives needed to organize an effective information-giving speech. A hierarchical structure of the behaviors needed to deliver a well-organized extemporaneous information-giving speech is presented, with some behaviors as subtasks for the unit objective and the others as…

Subtask 12D3: Fracture properties of V-5Cr-5Ti Alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, H.; Hamilton, M.L.; Jones, R.H.

1995-03-01

The purpose of this research is to investigate the effect of heat treatment on microstructure and fracture toughness of a V-5Cr-5Ti alloy in the range -50-100{degrees}C. Fracture toughness and impact tests were performed on a V-5Cr-5Ti alloy. Specimens annealed at 1125{degrees}C for 1 h and furnace cooled in a vacuum of 1.33 x 10{sup -5} Pa were brittle at room temperature (RT) and experienced a mixture of intergranular and cleavage fracture. Fracture toughness (J{sub IQ}) at RT was 52 kJ/m{sup 2} and the impact fracture energy (IFE) was 6 J. The IFE at -100{degrees}C was only 1 J. While specimensmore » exhibited high fracture toughness at 100{degrees}C (J{sub IQ} is 485 kj/m{sup 2}), fracture was a mixture of dimple and intergranular failure, with intergranular fracture making up 40% of the total fracture surface. The ductile to brittle transition temperature (DBTT) was estimated to be about 20{degrees}C. When some specimens were given an additional annealing at 890{degrees}C for 24 h, they became very ductile at RT and fractured by microvoid coalescence. The J{sub IQ} value increased from 52 kJ/m{sup 2} to {approximately}1100 kJ/m{sup 2}. The impact test failed to fracture specimens at RT due to a large amount of plastic deformation. 7 refs., 1 fig., 6 tabs.« less

Comparative research on response stereotypes for daily operation tasks of Chinese and American engineering students.

PubMed

Yu, Rui-Feng; Chan, Alan H S

2004-02-01

A group of Mainland Chinese engineering students were asked to respond to 12 questions by indicating their design conventions and expectations about operations, directions-of-motion, and descriptions of movement for items such as doors, keys, taps, and knobs. Chi-square tests demonstrated strong response stereotypes for tasks of all 12 questions. A comparison of the stereotype strengths found here with that of Hong Kong Chinese and American engineering students reported earlier indicated that stereotype strengths of engineering students from the three regions were generally different. For some cases stereotype characteristics of two regions were more alike than the other, and also for some subjects in the three regions performed similarly. The Mainland and Hong Kong Chinese were more alike in making their choices on questions of conceptual compatibility, while more consistent preferences on movement compatibility and spatial compatibility were noted between the Mainland Chinese and American students than Hong Kong Chinese.

Evidence of the evolved nature of the B[e] star MWC 137

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muratore, M. F.; Arias, M. L.; Cidale, L.

2015-01-01

The evolutionary phase of B[e] stars is difficult to establish due to the uncertainties in their fundamental parameters. For instance, possible classifications for the Galactic B[e] star MWC 137 include pre-main-sequence and post-main-sequence phases, with a large range in luminosity. Our goal is to clarify the evolutionary stage of this peculiar object, and to study the CO molecular component of its circumstellar medium. To this purpose, we modeled the CO molecular bands using high-resolution K-band spectra. We find that MWC 137 is surrounded by a detached cool (T=1900±100 K) and dense (N=(3±1)×10{sup 21} cm{sup −2}) ring of CO gas orbitingmore » the star with a rotational velocity, projected to the line of sight, of 84 ± 2 km s{sup −1}. We also find that the molecular gas is enriched in the isotope {sup 13}C, excluding the classification of the star as a Herbig Be. The observed isotopic abundance ratio ({sup 12}C/{sup 13}C = 25 ± 2) derived from our modeling is compatible with a proto-planetary nebula, main-sequence, or supergiant evolutionary phase. However, based on some observable characteristics of MWC 137, we propose that the supergiant scenario seems to be the most plausible. Hence, we suggest that MWC 137 could be in an extremely short-lived phase, evolving from a B[e] supergiant to a blue supergiant with a bipolar ring nebula.« less

HESS observations of the galactic center region and their possible dark matter interpretation.

PubMed

Aharonian, F; Akhperjanian, A G; Bazer-Bachi, A R; Beilicke, M; Benbow, W; Berge, D; Bernlöhr, K; Boisson, C; Bolz, O; Borrel, V; Braun, I; Breitling, F; Brown, A M; Bühler, R; Büsching, I; Carrigan, S; Chadwick, P M; Chounet, L-M; Cornils, R; Costamante, L; Degrange, B; Dickinson, H J; Djannati-Ataï, A; Drury, L O'C; Dubus, G; Egberts, K; Emmanoulopoulos, D; Espigat, P; Feinstein, F; Ferrero, E; Fiasson, A; Fontaine, G; Funk, Seb; Funk, S; Gallant, Y A; Giebels, B; Glicenstein, J F; Goret, P; Hadjichristidis, C; Hauser, D; Hauser, M; Heinzelmann, G; Henri, G; Hermann, G; Hinton, J A; Hofmann, W; Holleran, M; Horns, D; Jacholkowska, A; de Jager, O C; Khélifi, B; Komin, Nu; Konopelko, A; Kosack, K; Latham, I J; Le Gallou, R; Lemière, A; Lemoine-Goumard, M; Lohse, T; Martin, J M; Martineau-Huynh, O; Marcowith, A; Masterson, C; McComb, T J L; de Naurois, M; Nedbal, D; Nolan, S J; Noutsos, A; Orford, K J; Osborne, J L; Ouchrif, M; Panter, M; Pelletier, G; Pita, S; Pühlhofer, G; Punch, M; Raubenheimer, B C; Raue, M; Rayner, S M; Reimer, A; Reimer, O; Ripken, J; Rob, L; Rolland, L; Rowell, G; Sahakian, V; Saugé, L; Schlenker, S; Schlickeiser, R; Schwanke, U; Sol, H; Spangler, D; Spanier, F; Steenkamp, R; Stegmann, C; Superina, G; Tavernet, J-P; Terrier, R; Théoret, C G; Tluczykont, M; van Eldik, C; Vasileiadis, G; Venter, C; Vincent, P; Völk, H J; Wagner, S J; Ward, M

2006-12-01

The detection of gamma rays from the source HESS J1745-290 in the Galactic Center (GC) region with the High Energy Spectroscopic System (HESS) array of Cherenkov telescopes in 2004 is presented. After subtraction of the diffuse gamma-ray emission from the GC ridge, the source is compatible with a point source with spatial extent less than 1.2;{'}(stat) (95% C.L.). The measured energy spectrum above 160 GeV is compatible with a power law with photon index of 2.25+/-0.04(stat)+/-0.10(syst) and no significant flux variation is detected. It is finally found that the bulk of the very high energy emission must have non-dark-matter origin.

Space nuclear power systems 1989; Proceedings of the 6th Symposium, Albuquerque, NM, Jan. 8-12, 1989. Vols. 1 & 2

NASA Technical Reports Server (NTRS)

El-Genk, Mohamed S. (Editor); Hoover, Mark D. (Editor)

1992-01-01

The present conference discusses such space nuclear power (SNP) issues as current design trends for SDI applications, ultrahigh heat-flux systems with curved surface subcooled nucleate boiling, design and manufacturing alternatives for low cost production of SNPs, a lightweight radioisotope heater for the Galileo mission, compatible materials for uranium fluoride-based gas core SNPs, Johnson noise thermometry for SNPs, and uranium nitride/rhenium compatibility studies for the SP-100 SNP. Also discussed are system issues in antimatter energy conversion, the thermal design of a heat source for a Brayton cycle radioisotope power system, structural and thermal analyses of an isotope heat source, a novel plant protection strategy for transient reactors, and beryllium toxicity.