Sample records for subthalamic pgo-like waves

  1. Microinjections into the pedunculopontine tegmentum: effects of the GABAA antagonist, bicuculline, on sleep, PGO waves and behavior.

    PubMed

    Sanford, L D; Hunt, W K; Ross, R J; Morrison, A R; Pack, A I

    1998-07-01

    Neurons in the peribrachial region (PB) at the pontine border are implicated in the generation of ponto-geniculo-occipital (PGO) waves, which appear spontaneously during rapid eye movement sleep (REM) and in association with alerting behaviors during waking, as well as in the regulation of REM itself. It has been hypothesized that PGO-related bursting in a subpopulation of these neurons results from low threshold spikes triggered by phasic hyperpolarizations or by excitatory inputs reaching a steadily hyperpolarized neuron. The hyperpolarization necessary for triggering the low threshold spikes may come from local GABA neurons or from GABAergic input into PB. To test the hypothesis that antagonizing GABA would alter PGO wave generation and/or behavioral state, we microinfused, in cats, the GABAA antagonist, bicuculline, locally into PB and monitored behavior, behavioral state and PGO waves recorded in the lateral geniculate bodies. Bicuculline produced no significant alteration in PGO wave activity. In 3 cats, bicuculline produced behaviors ranging from spontaneous orienting and startle (4 cats) to flight behaviors (2 cats) and aggressiveness (2 cats), an effect probably due to diffusion into the central gray region. Thus, the results do not support a GABAA-ergic role in PB in the generation of PGO waves.

  2. Central administration of a 5-HT2 receptor agonist and antagonist: lack of effect on rapid eye movement sleep and pgo waves.

    PubMed

    Sanford, L D; Hunt, W K; Ross, R J; Pack, A I; Morrison, A R

    1998-01-01

    Serotonin (5-HT) has a role in regulating behavioral state and controlling the production of ponto-geniculo-occipital (PGO) waves, though the exact mechanism of action is not known. The most prevailing explanation is that 5-HT exerts its influence on behavioral state and PGO waves by inhibiting and disinhibiting cholinergic cells in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT), which have been implicated in their generation. Recent work in rats has demonstrated 5-HT2 receptors on most cholinergic cells in PPT/LDT. We microinfused the relatively specific 5-HT2 agonist, DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane), the relatively specific 5-HT2 antagonist, ketanserin, and the nonspecific 5-HT antagonist, methysergide, locally into the peribrachial region of PPT in cats and monitored behavioral state and PGO waves. Neither drug significantly affected behavioral state or PGO wave activity. These results suggest that 5-HT2 receptors associated with cholinergic cells are minimally involved in the control of behavioral state and, together with the recent findings of others, suggest that 5-HT may not modulate PGO wave generation via direct action on cholinergic neurons in PPT/LDT, a departure from the long-held but minimally-tested view.

  3. Analysis of new charge-neutral DNA/RNA analogues phosphoryl guanidine oligonucleotides (PGO) by gel electrophoresis.

    PubMed

    Fokina, Alesya; Wang, Meiling; Ilyina, Anna; Klabenkova, Kristina; Burakova, Ekaterina; Chelobanov, Boris; Stetsenko, Dmitry

    2018-06-02

    Analysis and isolation of new charge-neutral phosphoryl guanidine oligonucleotides (PGO) by vertical slab electrophoresis were tested at different pH values (3-11) or in the presence of SDS as a micelle-forming agent. The most convenient way to analyze and purify phosphoryl guanidine oligonucleotides was by denaturing PAGE (8 M urea) at pH 3. The mobility of PGO is dependent on their A + C content. To analyze PGO containing only G, T or U, denaturing PAGE at pH 11 can be used, although the conditions need to be optimized. Bands were visualized by UV shadowing or Coomassie Brilliant Blue staining. Copyright © 2018. Published by Elsevier Inc.

  4. One-pot electrochemical growth of sponge-like polyaniline-intercalated phosphorous-doped graphene oxide on nickel foam as binder-free electrode material of supercapacitor

    NASA Astrophysics Data System (ADS)

    Bigdeli, Hadise; Moradi, Morteza; Borhani, Saeid; Jafari, Elnaz Abbasi; Hajati, Shaaker; Kiani, Mohammad Ali

    2018-06-01

    In this work, phosphor-doped graphene oxide (PGO) was synthesized by chemical technique. Also, the sponge-like PGO@polyaniline nanocomposite (PGO@PANI) film was coated on the nickel foam by one-step electropolymerization. The active materials were then characterized by Fourier transforms infrared spectroscopy, scanning electron microscopy and energy dispersive X-ray spectroscopy, X-ray diffraction, and Brunauer-Emmett-Teller technique. When PANI/PGO was used as supercapacitor electrode, under current density of 1 A/g, the specific capacitance of the prepared PGO@PANI was measured as 603 F/g, which is 6.0 times higher than that of pure PANI (102 F/g). Moreover, capacity stability of the PANI/PGO increased significantly as compared to PANI (65% vs. 44%) after increasing the current density from 1 to 15 A/g. The clear electrochemical performance of PANI/PGO was enhanced owing to the synergistic effect of PGO and PANI. Our results demonstrate that PANI/PGO nanosheet arrays are promising candidate for electrode supercapacitor applications.

  5. Subthalamic nucleus modulates social and anxogenic-like behaviors.

    PubMed

    Reymann, Jean-Michel; Naudet, Florian; Pihan, Morgane; Saïkali, Stephan; Laviolle, Bruno; Bentué-Ferrer, Danièle

    2013-09-01

    In Parkinson's disease, global social maladjustment and anxiety are frequent after subthalamic nucleus (STN) stimulation and are generally considered to be linked with sociofamilial alterations induced by the motor effects of stimulation. We hypothesized that the STN is per se involved in these changes and aimed to explore the role of STN in social and anxogenic-like behaviors using an animal model. Nineteen male Wistar rats with bilateral lesions of the STN were compared with 26 sham-lesioned rats by synchronizing an ethological approach based upon direct observation of social behaviors and a standardized approach, the elevated plus maze (EPM). Comparisons between groups were performed by a Mann-Whitney-Wilcoxon test. Lesioned rats showed impairments in their social (P=0.05) and aggressive behaviors with a diminution of attacking (P=0.04) and chasing (P=0.06). In the EPM, concerning the open arms, the percentage of distance, time, inactive time, and entry were significantly decreased in lesioned rats (P=0.02, P=0.01, P=0.04, and P=0.05). The time spent in non-protected head dips was also diminished in the lesioned rats (P=0.01). These results strongly implicate the STN in social behavior and anxogenic-like behavior. In human, as DBS induces changes in the underlying dynamics of the stimulated brain networks, it could create an abnormal brain state in which anxiety and social behavior are altered. These results highlight another level of complexity of the behavioral changes after stimulation. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Decisional impulsivity and the associative-limbic subthalamic nucleus in obsessive-compulsive disorder: stimulation and connectivity

    PubMed Central

    Voon, Valerie; Droux, Fabien; Morris, Laurel; Chabardes, Stephan; Bougerol, Thierry; David, Olivier; Krack, Paul; Polosan, Mircea

    2017-01-01

    Abstract Why do we make hasty decisions for short-term gain? Rapid decision-making with limited accumulation of evidence and delay discounting are forms of decisional impulsivity. The subthalamic nucleus is implicated in inhibitory function but its role in decisional impulsivity is less well-understood. Here we assess decisional impulsivity in subjects with obsessive compulsive disorder who have undergone deep brain stimulation of the limbic and associative subthalamic nucleus. We show that stimulation of the subthalamic nucleus is causally implicated in increasing decisional impulsivity with less accumulation of evidence during probabilistic uncertainty and in enhancing delay discounting. Subthalamic stimulation shifts evidence accumulation in subjects with obsessive-compulsive disorder towards a functional less cautious style closer to that of healthy controls emphasizing its adaptive nature. Thus, subjects with obsessive compulsive disorder on subthalamic stimulation may be less likely to check for evidence (e.g. checking that the stove is on) with no difference in subjective confidence (or doubt). In a separate study, we replicate in humans (154 healthy controls) using resting state functional connectivity, tracing studies conducted in non-human primates dissociating limbic, associative and motor frontal hyper-direct connectivity with anterior and posterior subregions of the subthalamic nucleus. We show lateralization of functional connectivity of bilateral ventral striatum to right anterior ventromedial subthalamic nucleus consistent with previous observations of lateralization of emotionally evoked activity to right ventral subthalamic nucleus. We use a multi-echo sequence with independent components analysis, which has been shown to have enhanced signal-to-noise ratio, thus optimizing visualization of small subcortical structures. These findings in healthy controls converge with the effective contacts in obsessive compulsive disorder patients localized

  7. Decisional impulsivity and the associative-limbic subthalamic nucleus in obsessive-compulsive disorder: stimulation and connectivity.

    PubMed

    Voon, Valerie; Droux, Fabien; Morris, Laurel; Chabardes, Stephan; Bougerol, Thierry; David, Olivier; Krack, Paul; Polosan, Mircea

    2017-02-01

    Why do we make hasty decisions for short-term gain? Rapid decision-making with limited accumulation of evidence and delay discounting are forms of decisional impulsivity. The subthalamic nucleus is implicated in inhibitory function but its role in decisional impulsivity is less well-understood. Here we assess decisional impulsivity in subjects with obsessive compulsive disorder who have undergone deep brain stimulation of the limbic and associative subthalamic nucleus. We show that stimulation of the subthalamic nucleus is causally implicated in increasing decisional impulsivity with less accumulation of evidence during probabilistic uncertainty and in enhancing delay discounting. Subthalamic stimulation shifts evidence accumulation in subjects with obsessive-compulsive disorder towards a functional less cautious style closer to that of healthy controls emphasizing its adaptive nature. Thus, subjects with obsessive compulsive disorder on subthalamic stimulation may be less likely to check for evidence (e.g. checking that the stove is on) with no difference in subjective confidence (or doubt). In a separate study, we replicate in humans (154 healthy controls) using resting state functional connectivity, tracing studies conducted in non-human primates dissociating limbic, associative and motor frontal hyper-direct connectivity with anterior and posterior subregions of the subthalamic nucleus. We show lateralization of functional connectivity of bilateral ventral striatum to right anterior ventromedial subthalamic nucleus consistent with previous observations of lateralization of emotionally evoked activity to right ventral subthalamic nucleus. We use a multi-echo sequence with independent components analysis, which has been shown to have enhanced signal-to-noise ratio, thus optimizing visualization of small subcortical structures. These findings in healthy controls converge with the effective contacts in obsessive compulsive disorder patients localized within the

  8. Brain networks modulated by subthalamic nucleus deep brain stimulation.

    PubMed

    Accolla, Ettore A; Herrojo Ruiz, Maria; Horn, Andreas; Schneider, Gerd-Helge; Schmitz-Hübsch, Tanja; Draganski, Bogdan; Kühn, Andrea A

    2016-09-01

    Deep brain stimulation of the subthalamic nucleus is an established treatment for the motor symptoms of Parkinson's disease. Given the frequent occurrence of stimulation-induced affective and cognitive adverse effects, a better understanding about the role of the subthalamic nucleus in non-motor functions is needed. The main goal of this study is to characterize anatomical circuits modulated by subthalamic deep brain stimulation, and infer about the inner organization of the nucleus in terms of motor and non-motor areas. Given its small size and anatomical intersubject variability, functional organization of the subthalamic nucleus is difficult to investigate in vivo with current methods. Here, we used local field potential recordings obtained from 10 patients with Parkinson's disease to identify a subthalamic area with an analogous electrophysiological signature, namely a predominant beta oscillatory activity. The spatial accuracy was improved by identifying a single contact per macroelectrode for its vicinity to the electrophysiological source of the beta oscillation. We then conducted whole brain probabilistic tractography seeding from the previously identified contacts, and further described connectivity modifications along the macroelectrode's main axis. The designated subthalamic 'beta' area projected predominantly to motor and premotor cortical regions additional to connections to limbic and associative areas. More ventral subthalamic areas showed predominant connectivity to medial temporal regions including amygdala and hippocampus. We interpret our findings as evidence for the convergence of different functional circuits within subthalamic nucleus' portions deemed to be appropriate as deep brain stimulation target to treat motor symptoms in Parkinson's disease. Potential clinical implications of our study are illustrated by an index case where deep brain stimulation of estimated predominant non-motor subthalamic nucleus induced hypomanic behaviour. © The

  9. Mobilization of the relaxable Staphylococcus aureus plasmid pC221 by the conjugative plasmid pGO1 involves three pC221 loci.

    PubMed Central

    Projan, S J; Archer, G L

    1989-01-01

    The Staphylococcus aureus plasmid pC221, a 4.6-kilobase multicopy chloramphenicol resistance plasmid that forms plasmid-protein relaxation complexes, was mobilized for transfer by the conjugative plasmid pGO1. Two open reading frames on the pC221 genome, now designated mobA and mobB, as well as a cis-acting locus, the putative oriT, were shown to be in involved in pC221 mobilization. The mobA (but not mobB) and oriT loci were required for pC221 relaxation, and relaxation was necessary but not sufficient for pC221 mobilization by pGO1. oriT was cloned onto a pE194 derivative and complemented in trans for both relaxation and mobilization. Mobilization of relaxable plasmids in S. aureus appears to be analogous to mobilization by donation observed in gram-negative bacteria. Images PMID:2703461

  10. Pathological gambling in Parkinson's disease: subthalamic oscillations during economics decisions.

    PubMed

    Rosa, Manuela; Fumagalli, Manuela; Giannicola, Gaia; Marceglia, Sara; Lucchiari, Claudio; Servello, Domenico; Franzini, Angelo; Pacchetti, Claudio; Romito, Luigi; Albanese, Alberto; Porta, Mauro; Pravettoni, Gabriella; Priori, Alberto

    2013-10-01

    Pathological gambling develops in up to 8% of patients with Parkinson's disease. Although the pathophysiology of gambling remains unclear, several findings argue for a dysfunction in the basal ganglia circuits. To clarify the role of the subthalamic nucleus in pathological gambling, we studied its activity during economics decisions. We analyzed local field potentials recorded from deep brain stimulation electrodes in the subthalamic nucleus while parkinsonian patients with (n = 8) and without (n = 9) pathological gambling engaged in an economics decision-making task comprising conflictual trials (involving possible risk-taking) and non conflictual trials. In all parkinsonian patients, subthalamic low frequencies (2-12 Hz) increased during economics decisions. Whereas, in patients without gambling, low-frequency oscillations exhibited a similar pattern during conflictual and non conflictual stimuli, in those with gambling, low-frequency activity increased significantly more during conflictual than during non conflictual stimuli. The specific low-frequency oscillatory pattern recorded in patients with Parkinson's disease who gamble could reflect a subthalamic dysfunction that makes their decisional threshold highly sensitive to risky options. When parkinsonian patients process stimuli related to an economics task, low-frequency subthalamic activity increases. This task-related change suggests that the cognitive-affective system that drives economics decisional processes includes the subthalamic nucleus. The specific subthalamic neuronal activity during conflictual decisions in patients with pathological gambling supports the idea that the subthalamic nucleus is involved in behavioral strategies and in the pathophysiology of gambling. Copyright © 2013 Movement Disorder Society.

  11. The Impact of Subthalamic Deep Brain Stimulation on Sleep-Wake Behavior: A Prospective Electrophysiological Study in 50 Parkinson Patients.

    PubMed

    Baumann-Vogel, Heide; Imbach, Lukas L; Sürücü, Oguzkan; Stieglitz, Lennart; Waldvogel, Daniel; Baumann, Christian R; Werth, Esther

    2017-05-01

    This prospective observational study was designed to systematically examine the effect of subthalamic deep brain stimulation (DBS) on subjective and objective sleep-wake parameters in Parkinson patients. In 50 consecutive Parkinson patients undergoing subthalamic DBS, we assessed motor symptoms, medication, the position of DBS electrodes within the subthalamic nucleus (STN), subjective sleep-wake parameters, 2-week actigraphy, video-polysomnography studies, and sleep electroencepahalogram frequency and dynamics analyses before and 6 months after surgery. Subthalamic DBS improved not only motor symptoms and reduced daily intake of dopaminergic agents but also enhanced subjective sleep quality and reduced sleepiness (Epworth Sleepiness Scale: -2.1 ± 3.8, p < .001). Actigraphy recordings revealed longer bedtimes (+1:06 ± 0:51 hours, p < .001) without shifting of circadian timing. Upon polysomnography, we observed an increase in sleep efficiency (+5.2 ± 17.6%, p = .005) and deep sleep (+11.2 ± 32.2 min, p = .017) and increased accumulation of slow-wave activity over the night (+41.0 ± 80.0%, p = .005). Rapid eye movement sleep features were refractory to subthalamic DBS, and the dynamics of sleep as assessed by state space analyses did not normalize. Increased sleep efficiency was associated with active electrode contact localization more distant from the ventral margin of the left subthalamic nucleus. Subthalamic DBS deepens and consolidates nocturnal sleep and improves daytime wakefulness in Parkinson patients, but several outcomes suggest that it does not normalize sleep. It remains elusive whether modulated activity in the STN directly contributes to changes in sleep-wake behavior, but dorsal positioning of electrodes within the STN is linked to improved sleep-wake outcomes. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

  12. Phase matters: A role for the subthalamic network during gait.

    PubMed

    Arnulfo, Gabriele; Pozzi, Nicolò Gabriele; Palmisano, Chiara; Leporini, Alice; Canessa, Andrea; Brumberg, Joachim; Pezzoli, Gianni; Matthies, Cordula; Volkmann, Jens; Isaias, Ioannis Ugo

    2018-01-01

    The role of the subthalamic nucleus in human locomotion is unclear although relevant, given the troublesome management of gait disturbances with subthalamic deep brain stimulation in patients with Parkinson's disease. We investigated the subthalamic activity and inter-hemispheric connectivity during walking in eight freely-moving subjects with Parkinson's disease and bilateral deep brain stimulation. In particular, we compared the subthalamic power spectral densities and coherence, amplitude cross-correlation and phase locking value between resting state, upright standing, and steady forward walking. We observed a phase locking value drop in the β-frequency band (≈13-35Hz) during walking with respect to resting and standing. This modulation was not accompanied by specific changes in subthalamic power spectral densities, which was not related to gait phases or to striatal dopamine loss measured with [123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane and single-photon computed tomography. We speculate that the subthalamic inter-hemispheric desynchronization in the β-frequency band reflects the information processing of each body side separately, which may support linear walking. This study also suggests that in some cases (i.e. gait) the brain signal, which could allow feedback-controlled stimulation, might derive from network activity.

  13. Subthalamic nucleus phase–amplitude coupling correlates with motor impairment in Parkinson’s disease

    PubMed Central

    van Wijk, Bernadette C.M.; Beudel, Martijn; Jha, Ashwani; Oswal, Ashwini; Foltynie, Tom; Hariz, Marwan I.; Limousin, Patricia; Zrinzo, Ludvic; Aziz, Tipu Z.; Green, Alexander L.; Brown, Peter; Litvak, Vladimir

    2016-01-01

    Objective High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson’s disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between the phase of beta band oscillations and the amplitude of high-frequency oscillations around 300 Hz. Methods We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. We correlated mean values of spectral power and phase–amplitude coupling with severity of hemibody bradykinesia/rigidity. In addition, we used simultaneously recorded magnetoencephalography to look at functional interactions between the subthalamic nucleus and ipsilateral motor cortex. Results Beta band power and phase–amplitude coupling within the subthalamic nucleus correlated positively with severity of motor impairment. This effect was more pronounced within the low-beta range, whilst coherence between subthalamic nucleus and motor cortex was dominant in the high-beta range. Conclusions We speculate that the beta band might impede pro-kinetic high-frequency activity patterns when phase–amplitude coupling is prominent. Furthermore, results provide evidence for a functional subdivision of the beta band into low and high frequencies. Significance Our findings contribute to the interpretation of oscillatory activity within the cortico-basal ganglia circuit. PMID:26971483

  14. Local vs. volume conductance activity of field potentials in the human subthalamic nucleus

    PubMed Central

    Marmor, Odeya; Valsky, Dan; Joshua, Mati; Bick, Atira S; Arkadir, David; Tamir, Idit; Bergman, Hagai; Israel, Zvi

    2017-01-01

    Subthalamic nucleus field potentials have attracted growing research and clinical interest over the last few decades. However, it is unclear whether subthalamic field potentials represent locally generated neuronal subthreshold activity or volume conductance of the organized neuronal activity generated in the cortex. This study aimed at understanding of the physiological origin of subthalamic field potentials and determining the most accurate method for recording them. We compared different methods of recordings in the human subthalamic nucleus: spikes (300–9,000 Hz) and field potentials (3–100 Hz) recorded by monopolar micro- and macroelectrodes, as well as by differential-bipolar macroelectrodes. The recordings were done outside and inside the subthalamic nucleus during electrophysiological navigation for deep brain stimulation procedures (150 electrode trajectories) in 41 Parkinson’s disease patients. We modeled the signal and estimated the contribution of nearby/independent vs. remote/common activity in each recording configuration and area. Monopolar micro- and macroelectrode recordings detect field potentials that are considerably affected by common (probably cortical) activity. However, bipolar macroelectrode recordings inside the subthalamic nucleus can detect locally generated potentials. These results are confirmed by high correspondence between the model predictions and actual correlation of neuronal activity recorded by electrode pairs. Differential bipolar macroelectrode subthalamic field potentials can overcome volume conductance effects and reflect locally generated neuronal activity. Bipolar macroelectrode local field potential recordings might be used as a biological marker of normal and pathological brain functions for future electrophysiological studies and navigation systems as well as for closed-loop deep brain stimulation paradigms. NEW & NOTEWORTHY Our results integrate a new method for human subthalamic recordings with a development of

  15. Bimanual Force Coordination in Parkinson’s Disease Patients with Bilateral Subthalamic Deep Brain Stimulation

    PubMed Central

    Gorniak, Stacey L.; McIntyre, Cameron C.; Alberts, Jay L.

    2013-01-01

    Objective Studies of bimanual actions similar to activities of daily living (ADLs) are currently lacking in evaluating fine motor control in Parkinson’s disease patients implanted with bilateral subthalamic deep brain stimulators. We investigated basic time and force characteristics of a bimanual task that resembles performance of ADLs in a group of bilateral subthalamic deep brain stimulation (DBS) patients. Methods Patients were evaluated in three different DBS parameter conditions off stimulation, on clinically derived stimulation parameters, and on settings derived from a patient-specific computational model. Model-based parameters were computed as a means to minimize spread of current to non-motor regions of the subthalamic nucleus via Cicerone Deep Brain Stimulation software. Patients were evaluated off parkinsonian medications in each stimulation condition. Results The data indicate that DBS parameter state does not affect most aspects of fine motor control in ADL-like tasks; however, features such as increased grip force and grip symmetry varied with the stimulation state. In the absence of DBS parameters, patients exhibited significant grip force asymmetry. Overall UPDRS-III and UPDRS-III scores associated with hand function were lower while patients were experiencing clinically-derived or model-based parameters, as compared to the off-stimulation condition. Conclusion While bilateral subthalamic DBS has been shown to alleviate gross motor dysfunction, our results indicate that DBS may not provide the same magnitude of benefit to fine motor coordination. PMID:24244388

  16. Ponto-geniculo-occipital-wave suppression amplifies lateral geniculate nucleus cell-size changes in monocularly deprived kittens.

    PubMed

    Shaffery, J P; Roffwarg, H P; Speciale, S G; Marks, G A

    1999-04-12

    We have previously shown that during the post-natal critical period of development of the cat visual system, 1 week of instrumental rapid eye movement (REM) sleep deprivation (IRSD) during 2 weeks of monocular deprivation (MD) results in significant amplification of the effects of solely the 2-week MD on cell-size in the binocular segment of the lateral geniculate nucleus (LGN) [36,40]. In this study, we examined whether elimination of ponto-geniculo-occipital (PGO)-wave phasic activity in the LGN during REM sleep (REMS), rather than suppression of all REMS state-related activity, would similarly yield enhanced plasticity effects on cell-size in LGN. PGO-activity was eliminated in LGN by bilateral pontomesencephalic lesions [8,32]. This method of removing phasic activation at the level of the LGN preserved sleep and wake proportions as well as the tonic activities (low voltage, fast frequency ECoG and low amplitude EMG) that characterize REM sleep. The lesions were performed in kittens on post-natal day 42, at the end of the first week of the 2-week period of MD, the same age when IRSD was started in the earlier study. LGN interlaminar cell-size disparity increased in the PGO-wave-suppressed animals as it had in behaviorally REM sleep-deprived animals. Smaller A1/A-interlaminar ratios reflect the increased disparity effect in both the REM sleep- and PGO-suppressed groups compared to animals subjected to MD-alone. With IRSD, the effect was achieved because the occluded eye-related, LGN A1-lamina cells tended to be smaller relative to their size after MD-alone, whereas after PGO-suppressing lesions, the A1-lamina cells retained their size and the non-occluded eye-related, A-lamina cells tended to be larger than after MD-alone. Despite this difference, for which several possible explanations are offered, these A1/A-interlaminar ratio data indicate that in conjunction either with suppression of the whole of the REMS state or selective removal of REM sleep phasic

  17. SUBTHALAMIC NUCLEUS NEURONS DIFFERENTIALLY ENCODE EARLY AND LATE ASPECTS OF SPEECH PRODUCTION.

    PubMed

    Lipski, W J; Alhourani, A; Pirnia, T; Jones, P W; Dastolfo-Hromack, C; Helou, L B; Crammond, D J; Shaiman, S; Dickey, M W; Holt, L L; Turner, R S; Fiez, J A; Richardson, R M

    2018-05-22

    Basal ganglia-thalamocortical loops mediate all motor behavior, yet little detail is known about the role of basal ganglia nuclei in speech production. Using intracranial recording during deep brain stimulation surgery in humans with Parkinson's disease, we tested the hypothesis that the firing rate of subthalamic nucleus neurons is modulated in sync with motor execution aspects of speech. Nearly half of seventy-nine unit recordings exhibited firing rate modulation, during a syllable reading task across twelve subjects (male and female). Trial-to-trial timing of changes in subthalamic neuronal activity, relative to cue onset versus production onset, revealed that locking to cue presentation was associated more with units that decreased firing rate, while locking to speech onset was associated more with units that increased firing rate. These unique data indicate that subthalamic activity is dynamic during the production of speech, reflecting temporally-dependent inhibition and excitation of separate populations of subthalamic neurons. SIGNIFICANCE STATEMENT The basal ganglia are widely assumed to participate in speech production, yet no prior studies have reported detailed examination of speech-related activity in basal ganglia nuclei. Using microelectrode recordings from the subthalamic nucleus during a single syllable reading task, in awake humans undergoing deep brain stimulation implantation surgery, we show that the firing rate of subthalamic nucleus neurons is modulated in response to motor execution aspects of speech. These results are the first to establish a role for subthalamic nucleus neurons in encoding of aspects of speech production, and they lay the groundwork for launching a modern subfield to explore basal ganglia function in human speech. Copyright © 2018 the authors.

  18. Reduced cortical innervation of the subthalamic nucleus in MPTP-treated parkinsonian monkeys

    PubMed Central

    Mathai, Abraham; Ma, Yuxian; Paré, Jean-Francois; Villalba, Rosa M.; Wichmann, Thomas

    2015-01-01

    The striatum and the subthalamic nucleus are the main entry points for cortical information to the basal ganglia. Parkinson’s disease affects not only the function, but also the morphological integrity of some of these inputs and their synaptic targets in the basal ganglia. Significant morphological changes in the cortico-striatal system have already been recognized in patients with Parkinson’s disease and in animal models of the disease. To find out whether the primate cortico-subthalamic system is also subject to functionally relevant morphological alterations in parkinsonism, we used a combination of light and electron microscopy anatomical approaches and in vivo electrophysiological methods in monkeys rendered parkinsonian following chronic exposure to low doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). At the light microscopic level, the density of vesicular glutamate transporter 1-positive (i.e. cortico-subthalamic) profiles in the dorsolateral part of the subthalamic nucleus (i.e. its sensorimotor territory) was 26.1% lower in MPTP-treated parkinsonian monkeys than in controls. These results were confirmed by electron microscopy studies showing that the number of vesicular glutamate transporter 1-positive terminals and of axon terminals forming asymmetric synapses in the dorsolateral subthalamic nucleus was reduced by 55.1% and 27.9%, respectively, compared with controls. These anatomical findings were in line with in vivo electrophysiology data showing a 60% reduction in the proportion of pallidal neurons that responded to electrical stimulation of the cortico-subthalamic system in parkinsonian monkeys. These findings provide strong evidence for a partial loss of the hyperdirect cortico-subthalamic projection in MPTP-treated parkinsonian monkeys. PMID:25681412

  19. Reduced cortical innervation of the subthalamic nucleus in MPTP-treated parkinsonian monkeys.

    PubMed

    Mathai, Abraham; Ma, Yuxian; Paré, Jean-Francois; Villalba, Rosa M; Wichmann, Thomas; Smith, Yoland

    2015-04-01

    The striatum and the subthalamic nucleus are the main entry points for cortical information to the basal ganglia. Parkinson's disease affects not only the function, but also the morphological integrity of some of these inputs and their synaptic targets in the basal ganglia. Significant morphological changes in the cortico-striatal system have already been recognized in patients with Parkinson's disease and in animal models of the disease. To find out whether the primate cortico-subthalamic system is also subject to functionally relevant morphological alterations in parkinsonism, we used a combination of light and electron microscopy anatomical approaches and in vivo electrophysiological methods in monkeys rendered parkinsonian following chronic exposure to low doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). At the light microscopic level, the density of vesicular glutamate transporter 1-positive (i.e. cortico-subthalamic) profiles in the dorsolateral part of the subthalamic nucleus (i.e. its sensorimotor territory) was 26.1% lower in MPTP-treated parkinsonian monkeys than in controls. These results were confirmed by electron microscopy studies showing that the number of vesicular glutamate transporter 1-positive terminals and of axon terminals forming asymmetric synapses in the dorsolateral subthalamic nucleus was reduced by 55.1% and 27.9%, respectively, compared with controls. These anatomical findings were in line with in vivo electrophysiology data showing a 60% reduction in the proportion of pallidal neurons that responded to electrical stimulation of the cortico-subthalamic system in parkinsonian monkeys. These findings provide strong evidence for a partial loss of the hyperdirect cortico-subthalamic projection in MPTP-treated parkinsonian monkeys. © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  20. Eye movements and abducens motoneuron behavior after cholinergic activation of the nucleus reticularis pontis caudalis.

    PubMed

    Márquez-Ruiz, Javier; Escudero, Miguel

    2010-11-01

    the aim of this work was to characterize eye movements and abducens (ABD) motoneuron behavior after cholinergic activation of the nucleus reticularis pontis caudalis (NRPC). six female adult cats were prepared for chronic recording of eye movements (using the scleral search-coil technique), electroencephalography, electromyography, ponto-geniculo-occipital (PGO) waves in the lateral geniculate nucleus, and ABD motoneuron activities after microinjections of the cholinergic agonist carbachol into the NRPC. unilateral microinjections of carbachol in the NRPC induced tonic and phasic phenomena in the oculomotor system. Tonic effects consisted of ipsiversive rotation to the injected side, convergence, and downward rotation of the eyes. Phasic effects consisted of bursts of rhythmic rapid eye movements directed contralaterally to the injected side along with PGO-like waves in the lateral geniculate and ABD nuclei. Although tonic effects were dependent on the level of drowsiness, phasic effects were always present and appeared along with normal saccades when the animal was vigilant. ABD motoneurons showed phasic activities associated with ABD PGO-like waves during bursts of rapid eye movements, and tonic and phasic activities related to eye position and velocity during alertness. the cholinergic activation of the NRPC induces oculomotor phenomena that are somewhat similar to those described during REM sleep. A precise comparison of the dynamics and timing of the eye movements further suggests that a temporal organization of both NRPCs is needed to reproduce the complexity of the oculomotor behavior during REM sleep.

  1. Cognitive functioning after subthalamic nucleotomy for refractory Parkinson's disease

    PubMed Central

    McCarter, R.; Walton, N.; Rowan, A.; Gill, S.; Palomo, M.

    2000-01-01

    OBJECTIVE—To evaluate whether subthalamic nucleotomy produces adverse cognitive effects in patients with Parkinson's disease.
METHOD—Twelve patients with Parkinson's disease underwent stereotactic surgery to the subthalamic nucleus. Presurgical and postsurgical neuropsychological assessment of attention, memory, executive function, language, and verbal intellect were undertaken with a battery of tests designed to minimise potential contamination of cognitive effects by motor symptoms.
RESULTS—There was no statistically significant difference in the cognitive tests results after operation for the group as a whole. Reliable change indexes were generated for the cognitive tests. Reliable change postoperatively was found on specific tests of verbal memory, attention, and planning. Left sided operations were associated with greater incidence of deterioration postsurgery.
CONCLUSIONS—Preliminary data on the first reported cognitive changes after subthalamic nucleotomy suggested few adverse cognitive effects of the surgery although discrete neuropsychological changes were seen in some patients. These effects were consistent with current theories on the cognitive functions of the basal ganglia.

 PMID:10864605

  2. Activation of the subthalamic region during emotional processing in Parkinson disease.

    PubMed

    Kühn, A A; Hariz, M I; Silberstein, P; Tisch, S; Kupsch, A; Schneider, G-H; Limousin-Dowsey, P; Yarrow, K; Brown, P

    2005-09-13

    To elucidate the involvement of the human subthalamic nucleus (STN) region in the processing or transmission of emotional information. Local field potentials (LFPs) were recorded from this region in 10 patients with Parkinson disease (PD) undergoing bilateral implantation of the STN for high-frequency stimulation. LFP recordings were made while patients viewed pleasant and unpleasant emotionally arousing and neutral pictures. A significant decrease (event-related desynchronization [ERD]) in the local alpha power (8 to 12 Hz) was found for all stimulus categories starting at about 0.5 seconds after stimulus presentation. However, 1 to 2 seconds poststimulus, the ERD was larger in trials of pleasant (mean ERD: 21.6 +/- 2.8%; p < 0.009) and unpleasant (mean ERD: 15.0 +/- 4.2%; p = 0.018) stimuli compared with neutral stimuli (mean ERD: 4.4 +/- 4.2%). The delayed modulation of alpha activity recorded from the area of the subthalamic nucleus in PD may reflect the processing or transmission of information related to emotional stimuli. "Limbic" activation in the region of the subthalamic nucleus may explain why high-frequency stimulation of the subthalamic nucleus alters affect in some patients with PD.

  3. Intra-operative characterisation of subthalamic oscillations in Parkinson’s disease

    PubMed Central

    Geng, Xinyi; Xu, Xin; Horn, Andreas; Li, Ningfei; Ling, Zhipei; Brown, Peter; Wang, Shouyan

    2018-01-01

    Objective This study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency. Methods Pre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson’s disease (PD) who underwent DBS in the subthalamic nucleus and intra-operative LFP recording at rest and during cued movements. Images were reconstructed and 3-D visualized using Lead-DBS® toolbox to determine the coordinates of contact. The resting spectral power and movement-related power modulation of LFP oscillations were estimated. Results Both subthalamic LFP activity recorded at rest and its modulation by movement had focal maxima in the alpha, beta and gamma bands. The spatial distribution of alpha band activity and its modulation was significantly different to that in the beta band. Moreover, there were significant differences in the scale and timing of movement related modulation across the frequency bands. Conclusion Subthalamic LFP activities within specific frequency bands can be distinguished by spatial topography and pattern of movement related modulation. Significance Assessment of the frequency, focality and pattern of movement related modulation of subthalamic LFPs reveals a heterogeneity of neural population activity in this region. This could potentially be leveraged to finesse intra-operative targeting and post-operative contact selection. PMID:29567582

  4. Watch-hand-like optical rogue waves in three-wave interactions.

    PubMed

    Chen, Shihua; Soto-Crespo, Jose M; Grelu, Philippe

    2015-01-12

    We investigate the resonant interaction of three optical pulses of different group velocity in quadratic media and report on the novel watch-hand-like super rogue wave patterns. In addition to having a giant wall-like hump, each rogue-wave hand involves a peak amplitude more than five times its background height. We attribute such peculiar structures to the nonlinear superposition of six Peregrine-type solitons. The robustness has been confirmed by numerical simulations. This stability along with the non-overlapping distribution property may facilitate the experimental diagnostics and observation of these super rogue waves.

  5. Deep brain stimulation of the subthalamic nucleus enhances emotional processing in Parkinson disease.

    PubMed

    Schneider, Frank; Habel, Ute; Volkmann, Jens; Regel, Sabine; Kornischka, Jürgen; Sturm, Volker; Freund, Hans-Joachim

    2003-03-01

    High-frequency electrical stimulation of the subthalamic nucleus is a new and highly effective therapy for complications of long-term levodopa therapy and motor symptoms in advanced Parkinson disease (PD). Clinical observations indicate additional influence on emotional behavior. Electrical stimulation of deep brain nuclei with pulse rates above 100 Hz provokes a reversible, lesioning-like effect. Here, the effect of deep brain stimulation of the subthalamic nucleus on emotional, cognitive, and motor performance in patients with PD (n = 12) was examined. The results were compared with the effects of a suprathreshold dose of levodopa intended to transiently restore striatal dopamine deficiency. Patients were tested during medication off/stimulation off (STIM OFF), medication off/stimulation on (STIM ON), and during the best motor state after taking levodopa without deep brain stimulation (MED). More positive self-reported mood and an enhanced mood induction effect as well as improvement in emotional memory during STIM ON were observed, while during STIM OFF, patients revealed reduced emotional performance. Comparable effects were revealed by STIM ON and MED. Cognitive performance was not affected by the different conditions and treatments. Deep brain stimulation of the subthalamic nucleus selectively enhanced affective processing and subjective well-being and seemed to be antidepressive. Levodopa and deep brain stimulation had similar effects on emotion. This finding may provide new clues about the neurobiologic bases of emotion and mood disorders, and it illustrates the important role of the basal ganglia and the dopaminergic system in emotional processing in addition to the well-known motor and cognitive functions.

  6. Subthalamic nucleus detects unnatural android movement.

    PubMed

    Ikeda, Takashi; Hirata, Masayuki; Kasaki, Masashi; Alimardani, Maryam; Matsushita, Kojiro; Yamamoto, Tomoyuki; Nishio, Shuichi; Ishiguro, Hiroshi

    2017-12-19

    An android, i.e., a realistic humanoid robot with human-like capabilities, may induce an uncanny feeling in human observers. The uncanny feeling about an android has two main causes: its appearance and movement. The uncanny feeling about an android increases when its appearance is almost human-like but its movement is not fully natural or comparable to human movement. Even if an android has human-like flexible joints, its slightly jerky movements cause a human observer to detect subtle unnaturalness in them. However, the neural mechanism underlying the detection of unnatural movements remains unclear. We conducted an fMRI experiment to compare the observation of an android and the observation of a human on which the android is modelled, and we found differences in the activation pattern of the brain regions that are responsible for the production of smooth and natural movement. More specifically, we found that the visual observation of the android, compared with that of the human model, caused greater activation in the subthalamic nucleus (STN). When the android's slightly jerky movements are visually observed, the STN detects their subtle unnaturalness. This finding suggests that the detection of unnatural movements is attributed to an error signal resulting from a mismatch between a visual input and an internal model for smooth movement.

  7. Personality, dopamine, and Parkinson's disease: Insights from subthalamic stimulation.

    PubMed

    Lhommée, Eugénie; Boyer, François; Wack, Maxime; Pélissier, Pierre; Klinger, Hélène; Schmitt, Emmanuelle; Bichon, Amélie; Fraix, Valérie; Chabardès, Stéphan; Mertens, Patrick; Castrioto, Anna; Kistner, Andrea; Broussolle, Emmanuel; Thobois, Stéphane; Krack, Paul

    2017-08-01

    Subthalamic stimulation improves the motor and neuropsychiatric symptoms of Parkinson's disease. However, the impact of this treatment on impulse control and personality is the subject of heavy debate. The objective of this study was to investigate personality changes after subthalamic stimulation. Using Cloninger's biosocial model, we assessed personality in 73 Parkinson's disease patients before and 12 months after subthalamic stimulation accompanied by a drastic reduction in dopaminergic medication. Changes in psychobehavioral symptoms were measured using a battery of validated clinical scales (apathy, depression, anxiety, hyperemotionality, mania, psychosis, punding, and impulse control behaviors). One year after surgery, the harm avoidance personality domain total score increased compared with the baseline (+2.8; 34 patients; P < 0.001), as did 3 of its 4 subdomains: anticipatory worry (+0.7; 10 patients; P = 0.005), shyness (+0.6; 7 patients; P = 0.03), and fatigability (+1.1; 10 patients; P = 0.0014). Evolution of the shyness personality trait correlated with the decrease in dopaminergic medication. Total scores in the other personality domains remained unchanged, except for extravagance, a subdomain of novelty seeking, and persistence, a subdomain of reward dependence, which both decreased following surgery (-0.3; 7 patients; and -0.6; 9 patients; P = 0.03 and P = 0.0019, respectively). Although apathy increased, other psychobehavioral symptoms, including impulse control behaviors and neuropsychiatric nonmotor fluctuations, improved. Depression and anhedonia remained stable. Scores in hypodopaminergia and neuropsychiatric nonmotor OFF correlated with harm avoidance. Scores in hyperdopaminergia and neuropsychiatric nonmotor ON correlated with novelty seeking. When subthalamic stimulation is applied in Parkinson's disease, significant changes in personality traits are observed, which may be related to postoperative tapering of

  8. An Extreme-ultraviolet Wave Generating Upward Secondary Waves in a Streamer-like Solar Structure

    NASA Astrophysics Data System (ADS)

    Zheng, Ruisheng; Chen, Yao; Feng, Shiwei; Wang, Bing; Song, Hongqiang

    2018-05-01

    Extreme-ultraviolet (EUV) waves, spectacular horizontally propagating disturbances in the low solar corona, always trigger horizontal secondary waves (SWs) when they encounter the ambient coronal structure. We present the first example of upward SWs in a streamer-like structure after the passing of an EUV wave. This event occurred on 2017 June 1. The EUV wave happened during a typical solar eruption including a filament eruption, a coronal mass ejection (CME), and a C6.6 flare. The EUV wave was associated with quasi-periodic fast propagating (QFP) wave trains and a type II radio burst that represented the existence of a coronal shock. The EUV wave had a fast initial velocity of ∼1000 km s‑1, comparable to high speeds of the shock and the QFP wave trains. Intriguingly, upward SWs rose slowly (∼80 km s‑1) in the streamer-like structure after the sweeping of the EUV wave. The upward SWs seemed to originate from limb brightenings that were caused by the EUV wave. All of the results show that the EUV wave is a fast-mode magnetohydrodynamic (MHD) shock wave, likely triggered by the flare impulses. We suggest that part of the EUV wave was probably trapped in the closed magnetic fields of the streamer-like structure, and upward SWs possibly resulted from the release of slow-mode trapped waves. It is believed that the interplay of the strong compression of the coronal shock and the configuration of the streamer-like structure is crucial for the formation of upward SWs.

  9. Distinct roles of dopamine and subthalamic nucleus in learning and probabilistic decision making.

    PubMed

    Coulthard, Elizabeth J; Bogacz, Rafal; Javed, Shazia; Mooney, Lucy K; Murphy, Gillian; Keeley, Sophie; Whone, Alan L

    2012-12-01

    Even simple behaviour requires us to make decisions based on combining multiple pieces of learned and new information. Making such decisions requires both learning the optimal response to each given stimulus as well as combining probabilistic information from multiple stimuli before selecting a response. Computational theories of decision making predict that learning individual stimulus-response associations and rapid combination of information from multiple stimuli are dependent on different components of basal ganglia circuitry. In particular, learning and retention of memory, required for optimal response choice, are significantly reliant on dopamine, whereas integrating information probabilistically is critically dependent upon functioning of the glutamatergic subthalamic nucleus (computing the 'normalization term' in Bayes' theorem). Here, we test these theories by investigating 22 patients with Parkinson's disease either treated with deep brain stimulation to the subthalamic nucleus and dopaminergic therapy or managed with dopaminergic therapy alone. We use computerized tasks that probe three cognitive functions-information acquisition (learning), memory over a delay and information integration when multiple pieces of sequentially presented information have to be combined. Patients performed the tasks ON or OFF deep brain stimulation and/or ON or OFF dopaminergic therapy. Consistent with the computational theories, we show that stopping dopaminergic therapy impairs memory for probabilistic information over a delay, whereas deep brain stimulation to the region of the subthalamic nucleus disrupts decision making when multiple pieces of acquired information must be combined. Furthermore, we found that when participants needed to update their decision on the basis of the last piece of information presented in the decision-making task, patients with deep brain stimulation of the subthalamic nucleus region did not slow down appropriately to revise their plan, a

  10. [Emotion and basal ganglia (II): what can we learn from subthalamic nucleus deep brain stimulation in Parkinson's disease?].

    PubMed

    Péron, J; Dondaine, T

    2012-01-01

    The subthalamic nucleus deep-brain stimulation Parkinson's disease patient model seems to represent a unique opportunity for studying the functional role of the basal ganglia and notably the subthalamic nucleus in human emotional processing. Indeed, in addition to constituting a therapeutic advance for severely disabled Parkinson's disease patients, deep brain stimulation is a technique, which selectively modulates the activity of focal structures targeted by surgery. There is growing evidence of a link between emotional impairments and deep-brain stimulation of the subthalamic nucleus. In this context, according to the definition of emotional processing exposed in the companion paper available in this issue, the aim of the present review will consist in providing a synopsis of the studies that investigated the emotional disturbances observed in subthalamic nucleus deep brain stimulation Parkinson's disease patients. This review leads to the conclusion that several emotional components would be disrupted after subthalamic nucleus deep brain stimulation in Parkinson's disease: subjective feeling, neurophysiological activation, and motor expression. Finally, after a description of the limitations of this study model, we discuss the functional role of the subthalamic nucleus (and the striato-thalamo-cortical circuits in which it is involved) in emotional processing. It seems reasonable to conclude that the striato-thalamo-cortical circuits are indeed involved in emotional processing and that the subthalamic nucleus plays a central in role the human emotional architecture. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  11. Differential impact of thalamic versus subthalamic deep brain stimulation on lexical processing.

    PubMed

    Krugel, Lea K; Ehlen, Felicitas; Tiedt, Hannes O; Kühn, Andrea A; Klostermann, Fabian

    2014-10-01

    Roles of subcortical structures in language processing are vague, but, interestingly, basal ganglia and thalamic Deep Brain Stimulation can go along with reduced lexical capacities. To deepen the understanding of this impact, we assessed word processing as a function of thalamic versus subthalamic Deep Brain Stimulation. Ten essential tremor patients treated with thalamic and 14 Parkinson׳s disease patients with subthalamic Deep Brain Stimulation performed an acoustic Lexical Decision Task ON and OFF stimulation. Combined analysis of task performance and event-related potentials allowed the determination of processing speed, priming effects, and N400 as neurophysiological correlate of lexical stimulus processing. 12 age-matched healthy participants acted as control subjects. Thalamic Deep Brain Stimulation prolonged word decisions and reduced N400 potentials. No comparable ON-OFF effects were present in patients with subthalamic Deep Brain Stimulation. In the latter group of patients with Parkinson' disease, N400 amplitudes were, however, abnormally low, whether under active or inactive Deep Brain Stimulation. In conclusion, performance speed and N400 appear to be influenced by state functions, modulated by thalamic, but not subthalamic Deep Brain Stimulation, compatible with concepts of thalamo-cortical engagement in word processing. Clinically, these findings specify cognitive sequels of Deep Brain Stimulation in a target-specific way. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Parkinsonian gait improves with bilateral subthalamic nucleus deep brain stimulation during cognitive multi-tasking.

    PubMed

    Chenji, Gaurav; Wright, Melissa L; Chou, Kelvin L; Seidler, Rachael D; Patil, Parag G

    2017-05-01

    Gait impairment in Parkinson's disease reduces mobility and increases fall risk, particularly during cognitive multi-tasking. Studies suggest that bilateral subthalamic deep brain stimulation, a common surgical therapy, degrades motor performance under cognitive dual-task conditions, compared to unilateral stimulation. To measure the impact of bilateral versus unilateral subthalamic deep brain stimulation on walking kinematics with and without cognitive dual-tasking. Gait kinematics of seventeen patients with advanced Parkinson's disease who had undergone bilateral subthalamic deep brain stimulation were examined off medication under three stimulation states (bilateral, unilateral left, unilateral right) with and without a cognitive challenge, using an instrumented walkway system. Consistent with earlier studies, gait performance declined for all six measured parameters under cognitive dual-task conditions, independent of stimulation state. However, bilateral stimulation produced greater improvements in step length and double-limb support time than unilateral stimulation, and achieved similar performance for other gait parameters. Contrary to expectations from earlier studies of dual-task motor performance, bilateral subthalamic deep brain stimulation may assist in maintaining temporal and spatial gait performance under cognitive dual-task conditions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Effects of repeated deep brain stimulation on depressive- and anxiety-like behavior in rats: comparing entopeduncular and subthalamic nuclei.

    PubMed

    Creed, Meaghan C; Hamani, Clement; Nobrega, José N

    2013-07-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or internal globus pallidus (GPi) has been routinely used for the treatment of some movement disorders. However, DBS may be associated with adverse psychiatric effects, such as depression, anxiety and impulsivity. To compare DBS applied to the entopeduncular nucleus (EPN; the rodent homolog of the GPi) and STN in terms of their effects on depressive- and anxiety-like behavior in rats. DBS was applied for 21 days (4 h a day) to either the STN or EPN. Rats then underwent behavioral testing on learned helplessness and elevated plus maze tasks before being sacrificed for brain analyses of zif268, BDNF and trkB mRNA as well as BDNF protein levels. Repeated DBS of the STN, but not of the EPN, led to impaired performance in the learned helplessness task, suggesting that STN-DBS induces or potentiates depressive-like behavior. There was no effect of DBS on elevated plus maze or on open field behavior. Repeated STN-DBS, but not EPN-DBS, led to decreased levels of BDNF and trkB mRNA in hippocampus. Acute stimulation of the STN or EPN resulted in similar changes in zif268 levels in several brain areas, except for the raphe where decreases were seen only after STB-DBS. Together these results indicate that the effects of STN- and EPN-DBS differ in behavioral and neurochemical respects. Results further suggest that the EPN may be a preferable target for clinical DBS when psychiatric side effects are considered insofar as it may be associated with a lower incidence of depressive-like behavior than the STN. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Subthalamic nucleus activity optimizes maximal effort motor responses in Parkinson's disease.

    PubMed

    Anzak, Anam; Tan, Huiling; Pogosyan, Alek; Foltynie, Thomas; Limousin, Patricia; Zrinzo, Ludvic; Hariz, Marwan; Ashkan, Keyoumars; Bogdanovic, Marko; Green, Alexander L; Aziz, Tipu; Brown, Peter

    2012-09-01

    The neural substrates that enable individuals to achieve their fastest and strongest motor responses have long been enigmatic. Importantly, characterization of such activities may inform novel therapeutic strategies for patients with hypokinetic disorders, such as Parkinson's disease. Here, we ask whether the basal ganglia may play an important role, not only in the attainment of maximal motor responses under standard conditions but also in the setting of the performance enhancements known to be engendered by delivery of intense stimuli. To this end, we recorded local field potentials from deep brain stimulation electrodes implanted bilaterally in the subthalamic nuclei of 10 patients with Parkinson's disease, as they executed their fastest and strongest handgrips in response to a visual cue, which was accompanied by a brief 96-dB auditory tone on random trials. We identified a striking correlation between both theta/alpha (5-12 Hz) and high-gamma/high-frequency (55-375 Hz) subthalamic nucleus activity and force measures, which explained close to 70% of interindividual variance in maximal motor responses to the visual cue alone, when patients were ON their usual dopaminergic medication. Loud auditory stimuli were found to enhance reaction time and peak rate of development of force still further, independent of whether patients were ON or OFF l-DOPA, and were associated with increases in subthalamic nucleus power over a broad gamma range. However, the contribution of this broad gamma activity to the performance enhancements observed was only modest (≤13%). The results implicate frequency-specific subthalamic nucleus activities as substantial factors in optimizing an individual's peak motor responses at maximal effort of will, but much less so in the performance increments engendered by intense auditory stimuli.

  15. Localization of beta and high-frequency oscillations within the subthalamic nucleus region.

    PubMed

    van Wijk, B C M; Pogosyan, A; Hariz, M I; Akram, H; Foltynie, T; Limousin, P; Horn, A; Ewert, S; Brown, P; Litvak, V

    2017-01-01

    Parkinsonian bradykinesia and rigidity are typically associated with excessive beta band oscillations in the subthalamic nucleus. Recently another spectral peak has been identified that might be implicated in the pathophysiology of the disease: high-frequency oscillations (HFO) within the 150-400 Hz range. Beta-HFO phase-amplitude coupling (PAC) has been found to correlate with severity of motor impairment. However, the neuronal origin of HFO and its usefulness as a potential target for deep brain stimulation remain to be established. For example, it is unclear whether HFO arise from the same neural populations as beta oscillations. We intraoperatively recorded local field potentials from the subthalamic nucleus while advancing DBS electrodes in 2 mm steps from 4 mm above the surgical target point until 2 mm below, resulting in 4 recording sites. Data from 26 nuclei from 14 patients were analysed. For each trajectory, we identified the recording site with the largest spectral peak in the beta range (13-30 Hz), and the largest peak in the HFO range separately. In addition, we identified the recording site with the largest beta-HFO PAC. Recording sites with largest beta power and largest HFO power coincided in 50% of cases. In the other 50%, HFO was more likely to be detected at a more superior recording site in the target area. PAC followed more closely the site with largest HFO (45%) than beta power (27%). HFO are likely to arise from spatially close, but slightly more superior neural populations than beta oscillations. Further work is necessary to determine whether the different activities can help fine-tune deep brain stimulation targeting.

  16. Crack Detection in Plates Using Coupled Rayleigh-Like Waves

    NASA Astrophysics Data System (ADS)

    Masserey, B.; Fromme, P.

    2008-02-01

    The use of coupled Rayleigh-like waves in aluminum plates with a view towards the non-destructive inspection of aircraft structures has been investigated experimentally and theoretically. Rayleigh-like waves transfer energy between both plate surfaces with a characteristic distance called the beatlength. A simple, analytical model and finite difference calculations are used to describe the reflection of Rayleigh-like waves at surface defects. Good agreement has been achieved with experimental results using either standard pulse-echo or laser interferometer measurements. The sensitivity for the detection and localization of small defects on both plate surfaces has been found to be very good. Selecting appropriate excitation frequency and position, a significant part of the energy of the Rayleigh-like wave can be transmitted past surface features, allowing the remote detection of defects in areas where access is restricted.

  17. Subthalamic nucleus stimulation influences expression and suppression of impulsive behaviour in Parkinson’s disease

    PubMed Central

    Ridderinkhof, K. Richard; Elias, William J.; Frysinger, Robert C.; Bashore, Theodore R.; Downs, Kara E.; van Wouwe, Nelleke C.; van den Wildenberg, Wery P. M.

    2010-01-01

    Past studies show beneficial as well as detrimental effects of subthalamic nucleus deep-brain stimulation on impulsive behaviour. We address this paradox by investigating individuals with Parkinson’s disease treated with subthalamic nucleus stimulation (n = 17) and healthy controls without Parkinson’s disease (n = 17) on performance in a Simon task. In this reaction time task, conflict between premature response impulses and goal-directed action selection is manipulated. We applied distributional analytic methods to separate the strength of the initial response impulse from the proficiency of inhibitory control engaged subsequently to suppress the impulse. Patients with Parkinson’s disease were tested when stimulation was either turned on or off. Mean conflict interference effects did not differ between controls and patients, or within patients when stimulation was on versus off. In contrast, distributional analyses revealed two dissociable effects of subthalamic nucleus stimulation. Fast response errors indicated that stimulation increased impulsive, premature responding in high conflict situations. Later in the reaction process, however, stimulation improved the proficiency with which inhibitory control was engaged to suppress these impulses selectively, thereby facilitating selection of the correct action. This temporal dissociation supports a conceptual framework for resolving past paradoxical findings and further highlights that dynamic aspects of impulse and inhibitory control underlying goal-directed behaviour rely in part on neural circuitry inclusive of the subthalamic nucleus. PMID:20861152

  18. Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease.

    PubMed

    Weiss, Daniel; Klotz, Rosa; Govindan, Rathinaswamy B; Scholten, Marlieke; Naros, Georgios; Ramos-Murguialday, Ander; Bunjes, Friedemann; Meisner, Christoph; Plewnia, Christian; Krüger, Rejko; Gharabaghi, Alireza

    2015-03-01

    Dynamic modulations of large-scale network activity and synchronization are inherent to a broad spectrum of cognitive processes and are disturbed in neuropsychiatric conditions including Parkinson's disease. Here, we set out to address the motor network activity and synchronization in Parkinson's disease and its modulation with subthalamic stimulation. To this end, 20 patients with idiopathic Parkinson's disease with subthalamic nucleus stimulation were analysed on externally cued right hand finger movements with 1.5-s interstimulus interval. Simultaneous recordings were obtained from electromyography on antagonistic muscles (right flexor digitorum and extensor digitorum) together with 64-channel electroencephalography. Time-frequency event-related spectral perturbations were assessed to determine cortical and muscular activity. Next, cross-spectra in the time-frequency domain were analysed to explore the cortico-cortical synchronization. The time-frequency modulations enabled us to select a time-frequency range relevant for motor processing. On these time-frequency windows, we developed an extension of the phase synchronization index to quantify the global cortico-cortical synchronization and to obtain topographic differentiations of distinct electrode sites with respect to their contributions to the global phase synchronization index. The spectral measures were used to predict clinical and reaction time outcome using regression analysis. We found that movement-related desynchronization of cortical activity in the upper alpha and beta range was significantly facilitated with 'stimulation on' compared to 'stimulation off' on electrodes over the bilateral parietal, sensorimotor, premotor, supplementary-motor, and prefrontal areas, including the bilateral inferior prefrontal areas. These spectral modulations enabled us to predict both clinical and reaction time improvement from subthalamic stimulation. With 'stimulation on', interhemispheric cortico

  19. Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson’s disease

    PubMed Central

    Klotz, Rosa; Govindan, Rathinaswamy B.; Scholten, Marlieke; Naros, Georgios; Ramos-Murguialday, Ander; Bunjes, Friedemann; Meisner, Christoph; Plewnia, Christian; Krüger, Rejko

    2015-01-01

    Dynamic modulations of large-scale network activity and synchronization are inherent to a broad spectrum of cognitive processes and are disturbed in neuropsychiatric conditions including Parkinson’s disease. Here, we set out to address the motor network activity and synchronization in Parkinson’s disease and its modulation with subthalamic stimulation. To this end, 20 patients with idiopathic Parkinson’s disease with subthalamic nucleus stimulation were analysed on externally cued right hand finger movements with 1.5-s interstimulus interval. Simultaneous recordings were obtained from electromyography on antagonistic muscles (right flexor digitorum and extensor digitorum) together with 64-channel electroencephalography. Time-frequency event-related spectral perturbations were assessed to determine cortical and muscular activity. Next, cross-spectra in the time-frequency domain were analysed to explore the cortico-cortical synchronization. The time-frequency modulations enabled us to select a time-frequency range relevant for motor processing. On these time-frequency windows, we developed an extension of the phase synchronization index to quantify the global cortico-cortical synchronization and to obtain topographic differentiations of distinct electrode sites with respect to their contributions to the global phase synchronization index. The spectral measures were used to predict clinical and reaction time outcome using regression analysis. We found that movement-related desynchronization of cortical activity in the upper alpha and beta range was significantly facilitated with ‘stimulation on’ compared to ‘stimulation off’ on electrodes over the bilateral parietal, sensorimotor, premotor, supplementary-motor, and prefrontal areas, including the bilateral inferior prefrontal areas. These spectral modulations enabled us to predict both clinical and reaction time improvement from subthalamic stimulation. With ‘stimulation on’, interhemispheric cortico

  20. Application of ANNs approach for wave-like and heat-like equations

    NASA Astrophysics Data System (ADS)

    Jafarian, Ahmad; Baleanu, Dumitru

    2017-12-01

    Artificial neural networks are data processing systems which originate from human brain tissue studies. The remarkable abilities of these networks help us to derive desired results from complicated raw data. In this study, we intend to duplicate an efficient iterative method to the numerical solution of two famous partial differential equations, namely the wave-like and heat-like problems. It should be noted that many physical phenomena such as coupling currents in a flat multi-strand two-layer super conducting cable, non-homogeneous elastic waves in soils and earthquake stresses, are described by initial-boundary value wave and heat partial differential equations with variable coefficients. To the numerical solution of these equations, a combination of the power series method and artificial neural networks approach, is used to seek an appropriate bivariate polynomial solution of the mentioned initial-boundary value problem. Finally, several computer simulations confirmed the theoretical results and demonstrating applicability of the method.

  1. Spike-like solitary waves in incompressible boundary layers driven by a travelling wave.

    PubMed

    Feng, Peihua; Zhang, Jiazhong; Wang, Wei

    2016-06-01

    Nonlinear waves produced in an incompressible boundary layer driven by a travelling wave are investigated, with damping considered as well. As one of the typical nonlinear waves, the spike-like wave is governed by the driven-damped Benjamin-Ono equation. The wave field enters a completely irregular state beyond a critical time, increasing the amplitude of the driving wave continuously. On the other hand, the number of spikes of solitary waves increases through multiplication of the wave pattern. The wave energy grows in a sequence of sharp steps, and hysteresis loops are found in the system. The wave energy jumps to different levels with multiplication of the wave, which is described by winding number bifurcation of phase trajectories. Also, the phenomenon of multiplication and hysteresis steps is found when varying the speed of driving wave as well. Moreover, the nature of the change of wave pattern and its energy is the stability loss of the wave caused by saddle-node bifurcation.

  2. Stress Wave Propagation in Viscoelastic-Plastic Rock-Like Materials.

    PubMed

    Lang, Liu; Song, Ki-Il; Zhai, Yue; Lao, Dezheng; Lee, Hang-Lo

    2016-05-17

    Rock-like materials are composites that can be regarded as a mixture composed of elastic, plastic, and viscous components. They exhibit viscoelastic-plastic behavior under a high-strain-rate loading according to element model theory. This paper presents an analytical solution for stress wave propagation in viscoelastic-plastic rock-like materials under a high-strain-rate loading and verifies the solution through an experimental test. A constitutive equation of viscoelastic-plastic rock-like materials was first established, and then kinematic and kinetic equations were then solved to derive the analytic solution for stress wave propagation in viscoelastic-plastic rock-like materials. An experimental test using the SHPB (Split Hopkinson Pressure Bar) for a concrete specimen was conducted to obtain a stress-strain curve under a high-strain-rate loading. Inverse analysis based on differential evolution was conducted to estimate undetermined variables for constitutive equations. Finally, the relationship between the attenuation factor and the strain rate in viscoelastic-plastic rock-like materials was investigated. According to the results, the frequency of the stress wave, viscosity coefficient, modulus of elasticity, and density play dominant roles in the attenuation of the stress wave. The attenuation decreases with increasing strain rate, demonstrating strongly strain-dependent attenuation in viscoelastic-plastic rock-like materials.

  3. Stress Wave Propagation in Viscoelastic-Plastic Rock-Like Materials

    PubMed Central

    Lang, Liu; Song, KI-IL; Zhai, Yue; Lao, Dezheng; Lee, Hang-Lo

    2016-01-01

    Rock-like materials are composites that can be regarded as a mixture composed of elastic, plastic, and viscous components. They exhibit viscoelastic-plastic behavior under a high-strain-rate loading according to element model theory. This paper presents an analytical solution for stress wave propagation in viscoelastic-plastic rock-like materials under a high-strain-rate loading and verifies the solution through an experimental test. A constitutive equation of viscoelastic-plastic rock-like materials was first established, and then kinematic and kinetic equations were then solved to derive the analytic solution for stress wave propagation in viscoelastic-plastic rock-like materials. An experimental test using the SHPB (Split Hopkinson Pressure Bar) for a concrete specimen was conducted to obtain a stress-strain curve under a high-strain-rate loading. Inverse analysis based on differential evolution was conducted to estimate undetermined variables for constitutive equations. Finally, the relationship between the attenuation factor and the strain rate in viscoelastic-plastic rock-like materials was investigated. According to the results, the frequency of the stress wave, viscosity coefficient, modulus of elasticity, and density play dominant roles in the attenuation of the stress wave. The attenuation decreases with increasing strain rate, demonstrating strongly strain-dependent attenuation in viscoelastic-plastic rock-like materials. PMID:28773500

  4. Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus.

    PubMed

    Temel, Yasin; Boothman, Laura J; Blokland, Arjan; Magill, Peter J; Steinbusch, Harry W M; Visser-Vandewalle, Veerle; Sharp, Trevor

    2007-10-23

    Bilateral, high-frequency stimulation (HFS) of the subthalamic nucleus (STN) is the surgical therapy of choice for movement disability in advanced Parkinson's disease (PD), but this procedure evokes debilitating psychiatric effects, including depressed mood, of unknown neural origin. Here, we report the unexpected finding that HFS of the STN inhibits midbrain 5-hydroxytryptamine (5-HT) neurons to evoke depression-related behavioral changes. We found that bilateral HFS of the STN consistently inhibited (40-50%) the firing rate of 5-HT neurons in the dorsal raphe nucleus of the rat, but not neighboring non-5-HT neurons. This effect was apparent at clinically relevant stimulation parameters (> or =100 Hz, > or =30 microA), was not elicited by HFS of either neighboring or remote structures to the STN, and was still present in rat models of PD. We also found that bilateral HFS of the STN evoked clear-cut, depressive-like behavior in a widely used experimental paradigm of depression (forced swim test), and this effect was also observed in a PD model. Importantly, the depressive-like behavior elicited by HFS of the STN was reversed by a selective 5-HT-enhancing antidepressant, thereby linking the behavioral change to decreased 5-HT neuronal activity. Overall, these findings link reduced 5-HT function to the psychiatric effects of HFS of the STN observed in PD patients and provide a rational basis for their clinical management. More generally, the powerful interaction between the STN and 5-HT system uncovered here offers insights into the high level of comorbidity of basal ganglia disease and mood disorder.

  5. Subthalamic Synchronized Oscillatory Activity Correlates With Motor Impairment in Patients With Parkinson’s Disease

    PubMed Central

    Neumann, Wolf-Julian; Degen, Katharina; Schneider, Gerd-Helge; Brücke, Christof; Huebl, Julius; Brown, Peter; Kühn, Andrea A.

    2016-01-01

    Objective Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a pathophysiological signature in patients with Parkinson’s disease (PD). The aim of this study was to investigate the potential association between oscillatory activity in the STN and symptom severity in PD. Methods Subthalamic local field potentials were recorded from 63 PD patients in a dopaminergic OFF state. Power-spectra were analyzed for the frequency range from 5 to 95 Hz and correlated with individual UPDRS-III motor scores in the OFF state. Results A correlation between total UPDRS-III scores and 8 to 35 Hz activity was revealed across all patients (ρ = 0.44, P <.0001). When correlating each frequency bin, a narrow range from 10 to 15 Hz remained significant for the correlation (false discovery rate corrected P <.05). Conclusion Our results show a correlation between local STN 8 to 35 Hz power and impairment in PD, further supporting the role of subthalamic oscillatory activity as a potential biomarker for PD. PMID:27548068

  6. Tractography patterns of subthalamic nucleus deep brain stimulation.

    PubMed

    Vanegas-Arroyave, Nora; Lauro, Peter M; Huang, Ling; Hallett, Mark; Horovitz, Silvina G; Zaghloul, Kareem A; Lungu, Codrin

    2016-04-01

    Deep brain stimulation therapy is an effective symptomatic treatment for Parkinson's disease, yet the precise mechanisms responsible for its therapeutic effects remain unclear. Although the targets of deep brain stimulation are grey matter structures, axonal modulation is known to play an important role in deep brain stimulation's therapeutic mechanism. Several white matter structures in proximity to the subthalamic nucleus have been implicated in the clinical benefits of deep brain stimulation for Parkinson's disease. We assessed the connectivity patterns that characterize clinically beneficial electrodes in Parkinson's disease patients, after deep brain stimulation of the subthalamic nucleus. We evaluated 22 patients with Parkinson's disease (11 females, age 57 ± 9.1 years, disease duration 13.3 ± 6.3 years) who received bilateral deep brain stimulation of the subthalamic nucleus at the National Institutes of Health. During an initial electrode screening session, one month after deep brain stimulation implantation, the clinical benefits of each contact were determined. The electrode was localized by coregistering preoperative magnetic resonance imaging and postoperative computer tomography images and the volume of tissue activated was estimated from stimulation voltage and impedance. Brain connectivity for the volume of tissue activated of deep brain stimulation contacts was assessed using probabilistic tractography with diffusion-tensor data. Areas most frequently connected to clinically effective contacts included the thalamus, substantia nigra, brainstem and superior frontal gyrus. A series of discriminant analyses demonstrated that the strength of connectivity to the superior frontal gyrus and the thalamus were positively associated with clinical effectiveness. The connectivity patterns observed in our study suggest that the modulation of white matter tracts directed to the superior frontal gyrus and the thalamus is associated with favourable clinical

  7. Deep brain stimulation of the subthalamic nucleus modulates sensitivity to decision outcome value in Parkinson’s disease

    NASA Astrophysics Data System (ADS)

    Seymour, Ben; Barbe, Michael; Dayan, Peter; Shiner, Tamara; Dolan, Ray; Fink, Gereon R.

    2016-09-01

    Deep brain stimulation (DBS) of the subthalamic nucleus in Parkinson’s disease is known to cause a subtle but important adverse impact on behaviour, with impulsivity its most widely reported manifestation. However, precisely which computational components of the decision process are modulated is not fully understood. Here we probe a number of distinct subprocesses, including temporal discount, outcome utility, instrumental learning rate, instrumental outcome sensitivity, reward-loss trade-offs, and perseveration. We tested 22 Parkinson’s Disease patients both on and off subthalamic nucleus deep brain stimulation (STN-DBS), while they performed an instrumental learning task involving financial rewards and losses, and an inter-temporal choice task for financial rewards. We found that instrumental learning performance was significantly worse following stimulation, due to modulation of instrumental outcome sensitivity. Specifically, patients became less sensitive to decision values for both rewards and losses, but without any change to the learning rate or reward-loss trade-offs. However, we found no evidence that DBS modulated different components of temporal impulsivity. In conclusion, our results implicate the subthalamic nucleus in a modulation of outcome value in experience-based learning and decision-making in Parkinson’s disease, suggesting a more pervasive role of the subthalamic nucleus in the control of human decision-making than previously thought.

  8. Deep brain stimulation of the subthalamic nucleus modulates sensitivity to decision outcome value in Parkinson’s disease

    PubMed Central

    Seymour, Ben; Barbe, Michael; Dayan, Peter; Shiner, Tamara; Dolan, Ray; Fink, Gereon R.

    2016-01-01

    Deep brain stimulation (DBS) of the subthalamic nucleus in Parkinson’s disease is known to cause a subtle but important adverse impact on behaviour, with impulsivity its most widely reported manifestation. However, precisely which computational components of the decision process are modulated is not fully understood. Here we probe a number of distinct subprocesses, including temporal discount, outcome utility, instrumental learning rate, instrumental outcome sensitivity, reward-loss trade-offs, and perseveration. We tested 22 Parkinson’s Disease patients both on and off subthalamic nucleus deep brain stimulation (STN-DBS), while they performed an instrumental learning task involving financial rewards and losses, and an inter-temporal choice task for financial rewards. We found that instrumental learning performance was significantly worse following stimulation, due to modulation of instrumental outcome sensitivity. Specifically, patients became less sensitive to decision values for both rewards and losses, but without any change to the learning rate or reward-loss trade-offs. However, we found no evidence that DBS modulated different components of temporal impulsivity. In conclusion, our results implicate the subthalamic nucleus in a modulation of outcome value in experience-based learning and decision-making in Parkinson’s disease, suggesting a more pervasive role of the subthalamic nucleus in the control of human decision-making than previously thought. PMID:27624437

  9. Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease.

    PubMed

    Mollion, Hélène; Dominey, Peter Ford; Broussolle, Emmanuel; Ventre-Dominey, Jocelyne

    2011-09-01

    Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color-response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age-matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. Copyright © 2011 Movement Disorder Society.

  10. Pulse duration settings in subthalamic stimulation for Parkinson's disease

    PubMed Central

    Steigerwald, Frank; Timmermann, Lars; Kühn, Andrea; Schnitzler, Alfons; Reich, Martin M.; Kirsch, Anna Dalal; Barbe, Michael Thomas; Visser‐Vandewalle, Veerle; Hübl, Julius; van Riesen, Christoph; Groiss, Stefan Jun; Moldovan, Alexia‐Sabine; Lin, Sherry; Carcieri, Stephen; Manola, Ljubomir

    2017-01-01

    ABSTRACT Background Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double‐blind conditions. Evidence‐based recommendations on optimal stimulator settings are needed. Results from the CUSTOM‐DBS study are reported, comparing 2 pulse durations. Methods A total of 15 patients were programmed using a pulse width of 30 µs (test) or 60 µs (control). Efficacy and side‐effect thresholds and unified PD rating scale (UPDRS) III were measured in meds‐off (primary outcome). The therapeutic window was the difference between patients’ efficacy and side effect thresholds. Results The therapeutic window was significantly larger at 30 µs than 60 µs (P = ·0009) and the efficacy (UPDRS III score) was noninferior (P = .00008). Interpretation Subthalamic neurostimulation at 30 µs versus 60 µs pulse width is equally effective on PD motor signs, is more energy efficient, and has less likelihood of stimulation‐related side effects. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. PMID:29165837

  11. Tunneling effects in electromagnetic wave scattering by nonspherical particles: A comparison of the Debye series and physical-geometric optics approximations

    NASA Astrophysics Data System (ADS)

    Bi, Lei; Yang, Ping

    2016-07-01

    The accuracy of the physical-geometric optics (PG-O) approximation is examined for the simulation of electromagnetic scattering by nonspherical dielectric particles. This study seeks a better understanding of the tunneling effect on the phase matrix by employing the invariant imbedding method to rigorously compute the zeroth-order Debye series, from which the tunneling efficiency and the phase matrix corresponding to the diffraction and external reflection are obtained. The tunneling efficiency is shown to be a factor quantifying the relative importance of the tunneling effect over the Fraunhofer diffraction near the forward scattering direction. Due to the tunneling effect, different geometries with the same projected cross section might have different diffraction patterns, which are traditionally assumed to be identical according to the Babinet principle. For particles with a fixed orientation, the PG-O approximation yields the external reflection pattern with reasonable accuracy, but ordinarily fails to predict the locations of peaks and minima in the diffraction pattern. The larger the tunneling efficiency, the worse the PG-O accuracy is at scattering angles less than 90°. If the particles are assumed to be randomly oriented, the PG-O approximation yields the phase matrix close to the rigorous counterpart, primarily due to error cancellations in the orientation-average process. Furthermore, the PG-O approximation based on an electric field volume-integral equation is shown to usually be much more accurate than the Kirchhoff surface integral equation at side-scattering angles, particularly when the modulus of the complex refractive index is close to unity. Finally, tunneling efficiencies are tabulated for representative faceted particles.

  12. Subthalamic Nucleus Deep Brain Stimulation Changes Velopharyngeal Control in Parkinson's Disease

    ERIC Educational Resources Information Center

    Hammer, Michael J.; Barlow, Steven M.; Lyons, Kelly E.; Pahwa, Rajesh

    2011-01-01

    Purpose: Adequate velopharyngeal control is essential for speech, but may be impaired in Parkinson's disease (PD). Bilateral subthalamic nucleus deep brain stimulation (STN DBS) improves limb function in PD, but the effects on velopharyngeal control remain unknown. We tested whether STN DBS would change aerodynamic measures of velopharyngeal…

  13. Subthalamic Nucleus Stimulation and Dysarthria in Parkinson's Disease: A PET Study

    ERIC Educational Resources Information Center

    Pinto, Serge; Thobois, Stephane; Costes, Nicolas; Le Bars, Didier; Benabid, Alim-Louis; Broussolle, Emmanuel; Pollak, Pierre; Gentil, Michele

    2004-01-01

    In Parkinson's disease, functional imaging studies during limb motor tasks reveal cerebral activation abnormalities that can be reversed by subthalamic nucleus (STN) stimulation. The effect of STN stimulation on parkinsonian dysarthria has not, however, been investigated using PET. The aim of the present study was to evaluate the effect of STN…

  14. Modulation of local field potential power of the subthalamic nucleus during isometric force generation in patients with Parkinson's disease.

    PubMed

    Florin, E; Dafsari, H S; Reck, C; Barbe, M T; Pauls, K A M; Maarouf, M; Sturm, V; Fink, G R; Timmermann, L

    2013-06-14

    Investigations of local field potentials of the subthalamic nucleus of patients with Parkinson's disease have provided evidence for pathologically exaggerated oscillatory beta-band activity (13-30 Hz) which is amenable to physiological modulation by, e.g., voluntary movement. Previous functional magnetic resonance imaging studies in healthy controls have provided evidence for an increase of subthalamic nucleus blood-oxygenation-level-dependant signal in incremental force generation tasks. However, the modulation of neuronal activity by force generation and its relationship to peripheral feedback remain to be elucidated. We hypothesised that beta-band activity in the subthalamic nucleus is modulated by incremental force generation. Subthalamic nucleus local field potentials were recorded intraoperatively in 13 patients with Parkinson's disease (37 recording sites) during rest and five incremental isometric force generation conditions of the arm with applied loads of 0-400 g (in 100-g increments). Repeated measures analysis of variance (ANOVA) revealed a modulation of local field potential (LFP) power in the upper beta-band (in 24-30 Hz; F(₃.₀₄₂)=4.693, p=0.036) and the gamma-band (in 70-76 Hz; F(₄)=4.116, p=0.036). Granger-causality was computed with the squared partial directed coherence and showed no significant modulation during incremental isometric force generation. Our findings indicate that the upper beta- and gamma-band power of subthalamic nucleus local field potentials are modulated by the physiological task of force generation in patients with Parkinson's disease. This modulation seems to be not an effect of a modulation of peripheral feedback. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

  15. Bilateral subthalamic or pallidal stimulation for Parkinson's disease affects neither memory nor executive functions: a consecutive series of 62 patients.

    PubMed

    Ardouin, C; Pillon, B; Peiffer, E; Bejjani, P; Limousin, P; Damier, P; Arnulf, I; Benabid, A L; Agid, Y; Pollak, P

    1999-08-01

    There is a renewal of interest in surgical approaches including lesions and deep brain stimulation directed at motor subcorticofrontal loops. Bilateral lesioning presents a far greater risk of adverse effects, especially cognitive impairment. Furthermore, the main advantages of the stimulation procedure over lesioning are adaptability and reversibility of effects. The aim of this study was to assess the influence of bilateral stimulation of the subthalamic nucleus or internal globus pallidus on memory and executive functions in Parkinson's disease. Sixty-two patients were assessed before and after 3 to 6 months of chronic bilateral stimulation of the subthalamic nucleus (n = 49) or internal globus pallidus (n = 13). The neuropsychological tests used were the Mattis Dementia Rating Scale, the Grober and Buschke Verbal Learning Test, the Wisconsin Card Sorting Test, category and literal fluency, graphic and motor series, the Stroop Test, and the Trail Making Test. Mood was evaluated by the Beck Depression Inventory. Only 4 of 25 cognitive variables were affected by deep brain stimulation. Under stimulation, performance improved for Parts A and B of the Trail Making Test, but there was a deterioration in literal and total lexical fluency. There was also a mild but significant improvement in mood. It may therefore be concluded that stimulation of the subthalamic nucleus or internal globus pallidus does not change the overall cognitive performance in Parkinson's disease and does not greatly affect the functioning of subcorticofrontal loops involved in cognition in humans. This relative absence of cognitive impairment in bilateral deep brain stimulation is likely because of the accurate positioning of the electrodes, allowing the effects of stimulation to be confined to sensorimotor circuits.

  16. Saturn -- Ribbon-like Wave Structure in Atmosphere

    NASA Image and Video Library

    1999-08-30

    A view of Saturn clouds extending from 40 N latitude shows a ribbon-like wave structure in the south with small convective features marking a westward jet in the north. This image was obtained on November 10, 1980 by NASA Voyager 1.

  17. Targeting of the Subthalamic Nucleus for Deep Brain Stimulation: A Survey Among Parkinson Disease Specialists.

    PubMed

    Hamel, Wolfgang; Köppen, Johannes A; Alesch, François; Antonini, Angelo; Barcia, Juan A; Bergman, Hagai; Chabardes, Stephan; Contarino, Maria Fiorella; Cornu, Philippe; Demmel, Walter; Deuschl, Günther; Fasano, Alfonso; Kühn, Andrea A; Limousin, Patricia; McIntyre, Cameron C; Mehdorn, H Maximilian; Pilleri, Manuela; Pollak, Pierre; Rodríguez-Oroz, Maria C; Rumià, Jordi; Samuel, Michael; Timmermann, Lars; Valldeoriola, Francesc; Vesper, Jan; Visser-Vandewalle, Veerle; Volkmann, Jens; Lozano, Andres M

    2017-03-01

    Deep brain stimulation within or adjacent to the subthalamic nucleus (STN) represents the most common stereotactic procedure performed for Parkinson disease. Better STN imaging is often regarded as a requirement for improving stereotactic targeting. However, it is unclear whether there is consensus about the optimal target. To obtain an expert opinion on the site regarded optimal for "STN stimulation," movement disorder specialists were asked to indicate their preferred position for an active contact on hard copies of the Schaltenbrand and Wahren atlas depicting the STN in all 3 planes. This represented an idealized setting, and it mimicked optimal imaging for direct target definition in a perfectly delineated STN. The suggested targets were heterogeneous, although some clustering was observed in the dorsolateral STN and subthalamic area. In particular, in the anteroposterior direction, the intended targets differed to a great extent. Most of the indicated targets are thought to also result in concomitant stimulation of structures adjacent to the STN, including the zona incerta, fields of Forel, and internal capsule. This survey illustrates that most sites regarded as optimal for STN stimulation are close to each other, but there appears to be no uniform perception of the optimal anatomic target, possibly influencing surgical results. The anatomic sweet zone for STN stimulation needs further specification, as this information is likely to make magnetic resonance imaging-based target definition less variable when applied to individual patients. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Subthalamic stimulation, oscillatory activity and connectivity reveal functional role of STN and network mechanisms during decision making under conflict.

    PubMed

    Hell, Franz; Taylor, Paul C J; Mehrkens, Jan H; Bötzel, Kai

    2018-05-01

    Inhibitory control is an important executive function that is necessary to suppress premature actions and to block interference from irrelevant stimuli. Current experimental studies and models highlight proactive and reactive mechanisms and claim several cortical and subcortical structures to be involved in response inhibition. However, the involved structures, network mechanisms and the behavioral relevance of the underlying neural activity remain debated. We report cortical EEG and invasive subthalamic local field potential recordings from a fully implanted sensing neurostimulator in Parkinson's patients during a stimulus- and response conflict task with and without deep brain stimulation (DBS). DBS made reaction times faster overall while leaving the effects of conflict intact: this lack of any effect on conflict may have been inherent to our task encouraging a high level of proactive inhibition. Drift diffusion modelling hints that DBS influences decision thresholds and drift rates are modulated by stimulus conflict. Both cortical EEG and subthalamic (STN) LFP oscillations reflected reaction times (RT). With these results, we provide a different interpretation of previously conflict-related oscillations in the STN and suggest that the STN implements a general task-specific decision threshold. The timecourse and topography of subthalamic-cortical oscillatory connectivity suggest the involvement of motor, frontal midline and posterior regions in a larger network with complementary functionality, oscillatory mechanisms and structures. While beta oscillations are functionally associated with motor cortical-subthalamic connectivity, low frequency oscillations reveal a subthalamic-frontal-posterior network. With our results, we suggest that proactive as well as reactive mechanisms and structures are involved in implementing a task-related dynamic inhibitory signal. We propose that motor and executive control networks with complementary oscillatory mechanisms are

  19. Langmuir-like waves and radiation in planetary foreshocks

    NASA Technical Reports Server (NTRS)

    Cairns, Iver H.; Robinson, P. A.; Anderson, R. R.; Gurnett, D. A.; Kurth, W. S.

    1995-01-01

    The basic objectives of this NASA Grant are to develop theoretical understandings (tested with spacecraft data) of the generation and characteristics of electron plasma waves, commonly known as Langmuir-like waves, and associated radiation near f(sub p) and 2f(sub p) in planetary foreshocks. (Here f(sub p) is plasma frequency.) Related waves and radiation in the source regions of interplanetary type III solar radio bursts provide a simpler observational and theoretical context for developing and testing such understandings. Accordingly, applications to type III bursts constitute a significant fraction of the research effort. The testing of the new Stochastic Growth Theory (SGT) for type III bursts, and its extension and testing for foreshock waves and radiation, constitutes a major longterm strategic goal of the research effort.

  20. The human subthalamic nucleus encodes the subjective value of reward and the cost of effort during decision-making

    PubMed Central

    Zénon, Alexandre; Duclos, Yann; Carron, Romain; Witjas, Tatiana; Baunez, Christelle; Régis, Jean; Azulay, Jean-Philippe; Brown, Peter; Eusebio, Alexandre

    2016-01-01

    Adaptive behaviour entails the capacity to select actions as a function of their energy cost and expected value and the disruption of this faculty is now viewed as a possible cause of the symptoms of Parkinson’s disease. Indirect evidence points to the involvement of the subthalamic nucleus—the most common target for deep brain stimulation in Parkinson’s disease—in cost-benefit computation. However, this putative function appears at odds with the current view that the subthalamic nucleus is important for adjusting behaviour to conflict. Here we tested these contrasting hypotheses by recording the neuronal activity of the subthalamic nucleus of patients with Parkinson’s disease during an effort-based decision task. Local field potentials were recorded from the subthalamic nucleus of 12 patients with advanced Parkinson’s disease (mean age 63.8 years ± 6.8; mean disease duration 9.4 years ± 2.5) both OFF and ON levodopa while they had to decide whether to engage in an effort task based on the level of effort required and the value of the reward promised in return. The data were analysed using generalized linear mixed models and cluster-based permutation methods. Behaviourally, the probability of trial acceptance increased with the reward value and decreased with the required effort level. Dopamine replacement therapy increased the rate of acceptance for efforts associated with low rewards. When recording the subthalamic nucleus activity, we found a clear neural response to both reward and effort cues in the 1–10 Hz range. In addition these responses were informative of the subjective value of reward and level of effort rather than their actual quantities, such that they were predictive of the participant’s decisions. OFF levodopa, this link with acceptance was weakened. Finally, we found that these responses did not index conflict, as they did not vary as a function of the distance from indifference in the acceptance decision. These findings show

  1. Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease

    PubMed Central

    Tai, Chun-Hwei; Yang, Ya-Chin; Pan, Ming-Kai; Huang, Chen-Syuan; Kuo, Chung-Chin

    2011-01-01

    An increase in neuronal burst activities in the subthalamic nucleus (STN) is a well-documented electrophysiological feature of Parkinson disease (PD). However, the causal relationship between subthalamic bursts and PD symptoms and the ionic mechanisms underlying the bursts remain to be established. Here, we have shown that T-type Ca2+ channels are necessary for subthalamic burst firing and that pharmacological blockade of T-type Ca2+ channels reduces motor deficits in a rat model of PD. Ni2+, mibefradil, NNC 55-0396, and efonidipine, which inhibited T-type Ca2+ currents in acutely dissociated STN neurons, but not Cd2+ and nifedipine, which preferentially inhibited L-type or the other non–T-type Ca2+ currents, effectively diminished burst activity in STN slices. Topical administration of inhibitors of T-type Ca2+ channels decreased in vivo STN burst activity and dramatically reduced the locomotor deficits in a rat model of PD. Cd2+ and nifedipine showed no such electrophysiological and behavioral effects. While low-frequency deep brain stimulation (DBS) has been considered ineffective in PD, we found that lengthening the duration of the low-frequency depolarizing pulse effectively improved behavioral measures of locomotion in the rat model of PD, presumably by decreasing the availability of T-type Ca2+ channels. We therefore conclude that modulation of subthalamic T-type Ca2+ currents and consequent burst discharges may provide new strategies for the treatment of PD. PMID:21737877

  2. A mathematical model of the chevron-like wave pattern on a weld piece

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dowden, J.; Kapadia, P.

    1996-12-31

    In welding processes in general the surface of a metallic weld displays a chevron-like pattern. Such a pattern is also clearly seen to be present if welding is carried out using a laser beam. In the welding process a laser beam is directed normally on the metal undergoing translation and usually penetrates it to form a keyhole. The keyhole is surrounded by a molten region, the weld pool. Even if a CO{sub 2} laser is used, there are numerous fluctuations and instabilities that occur, so that the keyhole imposes forcing frequencies on the molten weld pool, additional to vibrations attendantmore » on the process of translation. The weld pool in turn responds by supporting a spectrum of waves of different frequencies involving the natural frequency of the weld pool as well as various forcing frequencies. These waves are surface tension-type capillary waves and previous publications have attempted to model their behavior mathematically, although not all aspects of the problem have always been included. The wave pattern that is manifested in the chevron-like pattern seen on the weld piece is, however, not necessarily identical to the wave pattern present in the weld pool. This is because the chevron-like wave pattern forms as a result of several complicating effects that arise as the weld specimen cools on its surface immediately after the weld has been formed. This process involves the waves on the surface of the weld pool freezing to form the chevron-like wave pattern. A feature that is often ignored is the fact that the waves on the weld pool can only be regarded as irrotational if the translation speed is sufficiently low. This paper describes mathematically the formation of the chevron-like wave pattern based on suitable simplifying assumptions to model the process. The mathematical description of the way in which this chevron-like pattern forms is a step toward a more comprehensive understanding of this process.« less

  3. Effects of dopaminergic and subthalamic stimulation on musical performance.

    PubMed

    van Vugt, Floris T; Schüpbach, Michael; Altenmüller, Eckart; Bardinet, Eric; Yelnik, Jérôme; Hälbig, Thomas D

    2013-05-01

    Although subthalamic-deep brain stimulation (STN-DBS) is an efficient treatment for Parkinson's disease (PD), its effects on fine motor functions are not clear. We present the case of a professional violinist with PD treated with STN-DBS. DBS improved musical articulation, intonation and emotional expression and worsened timing relative to a timekeeper (metronome). The same effects were found for dopaminergic treatment. These results suggest that STN-DBS, mimicking the effects of dopaminergic stimulation, improves fine-tuned motor behaviour whilst impairing timing precision.

  4. Subthalamic nucleus deep brain stimulation for Parkinson's disease: evidence for effectiveness and limitations from 12 years' experience.

    PubMed

    Chan, Anne Y Y; Yeung, Jonas H M; Mok, Vincent C T; Ip, Vincent H L; Wong, Adrian; Kuo, S H; Chan, Danny T M; Zhu, X L; Wong, Edith; Lau, Claire K Y; Wong, Rosanna K M; Tang, Venus; Lau, Christine; Poon, W S

    2014-12-01

    To present the result and experience of subthalamic nucleus deep brain stimulation for Parkinson's disease. Case series. Prince of Wales Hospital, Hong Kong. A cohort of patients with Parkinson's disease received subthalamic nucleus deep brain stimulation from September 1998 to January 2010. Patient assessment data before and after the operation were collected prospectively. Forty-one patients (21 male and 20 female) with Parkinson's disease underwent bilateral subthalamic nucleus deep brain stimulation and were followed up for a median interval of 12 months. For the whole group, the mean improvements of Unified Parkinson's Disease Rating Scale (UPDRS) parts II and III were 32.5% and 31.5%, respectively (P<0.001). Throughout the years, a multidisciplinary team was gradually built. The deep brain stimulation protocol evolved and was substantiated by updated patient selection criteria and outcome assessment, integrated imaging and neurophysiological targeting, refinement of surgical technique as well as the accumulation of experience in deep brain stimulation programming. Most of the structural improvement occurred before mid-2005. Patients receiving the operation before June 2005 (19 cases) and after (22 cases) were compared; the improvements in UPDRS part III were 13.2% and 55.2%, respectively (P<0.001). There were three operative complications (one lead migration, one cerebral haematoma, and one infection) in the group operated on before 2005. There was no operative mortality. The functional state of Parkinson's disease patients with motor disabilities refractory to best medical treatment improved significantly after subthalamic nucleus deep brain stimulation. A dedicated multidisciplinary team building, refined protocol for patient selection and assessment, improvement of targeting methods, meticulous surgical technique, and experience in programming are the key factors contributing to the improved outcome.

  5. The human subthalamic nucleus encodes the subjective value of reward and the cost of effort during decision-making.

    PubMed

    Zénon, Alexandre; Duclos, Yann; Carron, Romain; Witjas, Tatiana; Baunez, Christelle; Régis, Jean; Azulay, Jean-Philippe; Brown, Peter; Eusebio, Alexandre

    2016-06-01

    Adaptive behaviour entails the capacity to select actions as a function of their energy cost and expected value and the disruption of this faculty is now viewed as a possible cause of the symptoms of Parkinson's disease. Indirect evidence points to the involvement of the subthalamic nucleus-the most common target for deep brain stimulation in Parkinson's disease-in cost-benefit computation. However, this putative function appears at odds with the current view that the subthalamic nucleus is important for adjusting behaviour to conflict. Here we tested these contrasting hypotheses by recording the neuronal activity of the subthalamic nucleus of patients with Parkinson's disease during an effort-based decision task. Local field potentials were recorded from the subthalamic nucleus of 12 patients with advanced Parkinson's disease (mean age 63.8 years ± 6.8; mean disease duration 9.4 years ± 2.5) both OFF and ON levodopa while they had to decide whether to engage in an effort task based on the level of effort required and the value of the reward promised in return. The data were analysed using generalized linear mixed models and cluster-based permutation methods. Behaviourally, the probability of trial acceptance increased with the reward value and decreased with the required effort level. Dopamine replacement therapy increased the rate of acceptance for efforts associated with low rewards. When recording the subthalamic nucleus activity, we found a clear neural response to both reward and effort cues in the 1-10 Hz range. In addition these responses were informative of the subjective value of reward and level of effort rather than their actual quantities, such that they were predictive of the participant's decisions. OFF levodopa, this link with acceptance was weakened. Finally, we found that these responses did not index conflict, as they did not vary as a function of the distance from indifference in the acceptance decision. These findings show that low

  6. Analysis of wave-like oscillations in parameters of sporadic E layer and neutral atmosphere

    NASA Astrophysics Data System (ADS)

    Mošna, Z.; Koucká Knížová, P.

    2012-12-01

    The present study mainly concerns the wave-like activity in the ionospheric sporadic E layer (Es) and in the lower lying stratosphere. The proposed analysis involves parameters describing the state of plasma in the sporadic E layer. Critical frequencies foEs and layer heights hEs were measured at the Pruhonice station (50°N, 14.5°E) during summer campaigns 2004, 2006 and 2008. Further, we use neutral atmosphere (temperature data at 10 hPa) data from the same time interval. The analysis concentrates on vertically propagating wave-like structures within distant atmospheric regions. By means of continuous wavelet transform (CWT) we have detected significant wave-like oscillation at periods covering tidal and planetary oscillation domains both in the Es layer parameters (some of them were reported earlier, for instance in works of Abdu et al., 2003; Pancheva and Mitchel, 2004; Pancheva et al., 2003; Šauli and Bourdillon, 2008) and in stratospheric temperature variations. Further analyses using cross wavelet transform (XWT) and wavelet coherence analysis (WTC) show that despite high wave-like activity in a wide period range, there are only limited coherent wave-like bursts present in both spectra. Such common coherent wave bursts occur on periods close to eigen-periods of the terrestrial atmosphere. We suppose that vertical coupling between atmospheric regions realized by vertically propagating planetary waves occurs predominantly on periods close to those of Rossby modes. Analysis of the phase shift between data from distant atmospheric regions reveals high variability and very likely supports the non-linear scenario of the vertical coupling provided by planetary waves.

  7. Ultrasonic-assisted synthesis of phosphorus graphene oxide/poly (vinyl alcohol) polymer and surface resistivity research of phosphorus graphene oxide/poly (vinyl alcohol) film.

    PubMed

    Li, Jihui; Li, Yongshen; Niu, Shuai; Li, Ning

    2017-05-01

    In this paper, phosphorus graphene oxide/poly (vinyl alcohol) polymer (PGO/PVA polymer) was synthesized by PGO and PVA via the esterification in the case of faint acidity and the ultrasound irradiation and characterized; moreover, phosphorus graphene oxide/poly (vinyl alcohol) film (PGO/PVA film) was prepared by PGO/PVA polymer and characterized; also, the surface resistivity of PGO/PVA film was investigated in the case of the different amount of PGO. Based on those, it had been found that PGO reacted with PVA to produce PGO/PVA polymer via the esterification under the ultrasonic-assisted condition, and PGO/PVA polymer was structured by 2D lattice of PGO and the chain of PVA connected in the form of six-member lactone ring and phosphonic ester, and PGO/PVA film was constituted by PGO/PVA polymer, and surface resistivity of 0.00, 0.75, 1.50, 2.25 and 3.00wt% of PGO/PVA film were 6.85×10 8 , 2.98×10 8 , 1.42×10 6 , 7.66×10 4 and 1.29×10 5 Ω/sq, respectively. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Effect of bilateral subthalamic electrical stimulation in Parkinson's disease.

    PubMed

    Broggi, G; Franzini, A; Ferroli, P; Servello, D; D'Incerti, L; Genitrini, S; Soliveri, P; Girotti, F; Caraceni, T

    2001-08-01

    Bilateral high frequency subthalamic stimulation has been reported to be effective in the treatment of Parkinson's disease and levodopa-induced dyskinesias. To analyze the results of this surgical procedure we critically reviewed 17 parkinsonian patients with advanced disease complicated by motor fluctuations and dyskinesias. Between January 1998 and June 1999 these 17 consecutive patients (age 48-68 years; illness duration 8-27 years) underwent bilateral stereotactically guided implantation of electrodes into the subthalamic nucleus in the Department of Neurosurgery of the Istituto Nazionale Neurologico "C. Besta." Parameters used for continuous high-frequency stimulation were: frequency 160 Hz, pulse width 90 microsec, mean amplitude 2.05 +/- 0.45 V. Parts II and III of the UPDRS were used to assess motor performance before and after operation by the neurologic team. The follow-up ranged between 6 and 18 months. At latest examination, mean UPDRS II and III scores had improved by 30% (on stimulation, off therapy) with mean 50% reduction in daily off time. Peak dyskinesias and early morning dystonias also improved in relation to therapy reduction. Side effects were persistent postoperative supranuclear oculomotor palsy and postural instability in one case, worsened off-medication hypophonia in three, and temporary nocturnal confusion episodes in three. Postoperative MRI revealed a clinically silent intracerebral haematoma in one case. One electrode required repositioning. Continuous high frequency STN stimulation is an effective treatment for advanced PD. A functionally useful and safe electrode placement can be performed without microrecording.

  9. Remote creation of hybrid entanglement between particle-like and wave-like optical qubits

    NASA Astrophysics Data System (ADS)

    Morin, Olivier; Huang, Kun; Liu, Jianli; Le Jeannic, Hanna; Fabre, Claude; Laurat, Julien

    2014-07-01

    The wave-particle duality of light has led to two different encodings for optical quantum information processing. Several approaches have emerged based either on particle-like discrete-variable states (that is, finite-dimensional quantum systems) or on wave-like continuous-variable states (that is, infinite-dimensional systems). Here, we demonstrate the generation of entanglement between optical qubits of these different types, located at distant places and connected by a lossy channel. Such hybrid entanglement, which is a key resource for a variety of recently proposed schemes, including quantum cryptography and computing, enables information to be converted from one Hilbert space to the other via teleportation and therefore the connection of remote quantum processors based upon different encodings. Beyond its fundamental significance for the exploration of entanglement and its possible instantiations, our optical circuit holds promise for implementations of heterogeneous network, where discrete- and continuous-variable operations and techniques can be efficiently combined.

  10. Spontaneous generation of bending waves in isolated Milky Way-like discs

    NASA Astrophysics Data System (ADS)

    Chequers, Matthew H.; Widrow, Lawrence M.

    2017-12-01

    We study the spontaneous generation and evolution of bending waves in N-body simulations of two isolated Milky Way-like galaxy models. The models differ by their disc-to-halo mass ratios, and hence by their susceptibility to the formation of a bar and spiral structure. Seeded from shot noise in the particle distribution, bending waves rapidly form in both models and persist for many billions of years. Waves at intermediate radii manifest as corrugated structures in vertical position and velocity that are tightly wound, morphologically leading and dominated by the m = 1 azimuthal Fourier component. A spectral analysis of the waves suggests they are a superposition of modes from two continuous branches in the Galactocentric radius-rotational frequency plane. The lower frequency branch is dominant and is responsible for the corrugated, leading and warped structure. Over time, power in this branch migrates outward, lending credence to an inside-out formation scenario for the warp. Our power spectra qualitatively agree with results from linear perturbation theory and a WKB analysis, both of which include self-gravity. Thus, we conclude that the waves in our simulations are self-gravitating and not purely kinematic. These waves are reminiscent of the wave-like pattern recently found in Galactic star counts from the Sloan Digital Sky Survey and smoothly transition to a warp near the disc's edge. Velocity measurements from Gaia data will be instrumental in testing the true wave nature of the corrugations. We also compile a list of 'minimum requirements' needed to observe bending waves in external galaxies.

  11. Subthalamic stimulation differentially modulates declarative and nondeclarative memory.

    PubMed

    Hälbig, Thomas D; Gruber, Doreen; Kopp, Ute A; Scherer, Peter; Schneider, Gerd-Helge; Trottenberg, Thomas; Arnold, Guy; Kupsch, Andreas

    2004-03-01

    Declarative memory has been reported to rely on the medial temporal lobe system, whereas non-declarative memory depends on basal ganglia structures. We investigated the functional role of the subthalamic nucleus (STN), a structure closely connected with the basal ganglia for both types of memory. Via deep brain high frequency stimulation (DBS) we manipulated neural activity of the STN in humans. We found that DBS-STN differentially modulated memory performance: declarative memory was impaired, whereas non-declarative memory was improved in the presence of STN-DBS indicating a specific role of the STN in the activation of memory systems. Copyright 2004 Lippincott Williams & Wilkins

  12. Sleep patterning and behaviour in cats with pontine lesions creating REM without atonia.

    PubMed

    Sanford; Morrison; Mann; Harris; Yoo; Ross

    1994-12-01

    Lesions of the dorsal pontine tegmentum release muscle tone and motor behaviour, much of it similar to orienting during wakefulness, into rapid eye movement sleep (REM), a state normally characterized by paralysis. Sleep after pontine lesions may be altered, with more REM-A episodes of shorter duration compared to normal REM. We examined behaviour, ponto-geniculo-occipital (PGO) waves (which may be central markers of orienting) and sleep in lesioned cats: (i) to characterize the relationship of PGO waves to behaviour in REM-A; (ii) to determine whether post-lesion changes in the timing and duration of REM-A episodes were due to activity-related awakenings: and (iii) to determine whether alterations in sleep changed the circadian sleep/wake cycle in cats. Behavioural release in REM-A was generally related to episode length, but episode length was not necessarily shorter than normal REM in cats capable of full locomotion in REM-A. PGO wave frequency was reduced overall during REM-A, but was higher during REM-A with behaviour than during quiet REM-A without overt behaviour. Pontine lesions did not significantly alter the circadian sleep/wake cycle: REM-A had approximately the same Light/Dark distribution as normal REM. Differences in the patterning of normal REM and REM-A within sleep involve more than mere movement-induced awakenings. Brainstem lesions that eliminate the atonia of REM may damage neural circuitry involved in REM initiation and maintenance; this circuitry is separate from circadian control mechanisms.

  13. Subthalamic nucleus deep brain stimulation affects distractor interference in auditory working memory.

    PubMed

    Camalier, Corrie R; Wang, Alice Y; McIntosh, Lindsey G; Park, Sohee; Neimat, Joseph S

    2017-03-01

    Computational and theoretical accounts hypothesize the basal ganglia play a supramodal "gating" role in the maintenance of working memory representations, especially in preservation from distractor interference. There are currently two major limitations to this account. The first is that supporting experiments have focused exclusively on the visuospatial domain, leaving questions as to whether such "gating" is domain-specific. The second is that current evidence relies on correlational measures, as it is extremely difficult to causally and reversibly manipulate subcortical structures in humans. To address these shortcomings, we examined non-spatial, auditory working memory performance during reversible modulation of the basal ganglia, an approach afforded by deep brain stimulation of the subthalamic nucleus. We found that subthalamic nucleus stimulation impaired auditory working memory performance, specifically in the group tested in the presence of distractors, even though the distractors were predictable and completely irrelevant to the encoding of the task stimuli. This study provides key causal evidence that the basal ganglia act as a supramodal filter in working memory processes, further adding to our growing understanding of their role in cognition. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Radiosurgical Subthalamic Nucleotomy.

    PubMed

    Régis, Jean; Carron, Romain; Witjas, Tatiana

    2018-01-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is the reference technique in Parkinson's disease (PD) at different stages of complications. Some patients cannot afford DBS due to anticoagulation or comorbidities or due to pecuniary reasons. Radiosurgery is a minimally invasive stereotactic technique, with no craniotomy and subsequently no risk of bleeding or infection. Its good safety efficacy profile has been established in the treatment of tremor, and the postoperative care issues are simple with a much shorter hospital stay (mean 48 h). The application of radiosurgery to STN target in PD as an alternative to DBS is being debated. The lesion of the STN is presumed to induce hemiballism. Experimental works suggest a potential lower risk of hemiballism in animal models of PD. However, radiofrequency ablation of the STN is associated with a significant rate of severe dyskinesia, sometimes permanent and severe enough to request salvage pallidotomies. The positive experience of VIM radiosurgery in tremor and its capacity to create precise, accurate and well-controlled lesions provides reasonable rationale for the evaluation of this technique when applied to STN in PD. Preliminary results till date have shown the absence of severe permanent dyskinesia. Prospective controlled trials are mandatory to evaluate the safety efficacy of this technique in PD. © 2018 S. Karger AG, Basel.

  15. Peri-Elastodynamic Simulations of Guided Ultrasonic Waves in Plate-Like Structure with Surface Mounted PZT.

    PubMed

    Patra, Subir; Ahmed, Hossain; Banerjee, Sourav

    2018-01-18

    Peridynamic based elastodynamic computation tool named Peri-elastodynamics is proposed herein to simulate the three-dimensional (3D) Lamb wave modes in materials for the first time. Peri-elastodynamics is a nonlocal meshless approach which is a scale-independent generalized technique to visualize the acoustic and ultrasonic waves in plate-like structure, micro-electro-mechanical systems (MEMS) and nanodevices for their respective characterization. In this article, the characteristics of the fundamental Lamb wave modes are simulated in a sample plate-like structure. Lamb wave modes are generated using a surface mounted piezoelectric (PZT) transducer which is actuated from the top surface. The proposed generalized Peri-elastodynamics method is not only capable of simulating two dimensional (2D) in plane wave under plane strain condition formulated previously but also capable of accurately simulating the out of plane Symmetric and Antisymmetric Lamb wave modes in plate like structures in 3D. For structural health monitoring (SHM) of plate-like structures and nondestructive evaluation (NDE) of MEMS devices, it is necessary to simulate the 3D wave-damage interaction scenarios and visualize the different wave features due to damages. Hence, in addition, to simulating the guided ultrasonic wave modes in pristine material, Lamb waves were also simulated in a damaged plate. The accuracy of the proposed technique is verified by comparing the modes generated in the plate and the mode shapes across the thickness of the plate with theoretical wave analysis.

  16. Resting state cortical oscillations of patients with Parkinson disease and with and without subthalamic deep brain stimulation: a magnetoencephalography study.

    PubMed

    Cao, Chunyan; Li, Dianyou; Jiang, Tianxiao; Ince, Nuri Firat; Zhan, Shikun; Zhang, Jing; Sha, Zhiyi; Sun, Bomin

    2015-04-01

    In this study, we investigate the modification to cortical oscillations of patients with Parkinson disease (PD) by subthalamic deep brain stimulation (STN-DBS). Spontaneous cortical oscillations of patients with PD were recorded with magnetoencephalography during on and off subthalamic nucleus deep brain stimulation states. Several features such as average frequency, average power, and relative subband power in regions of interest were extracted in the frequency domain, and these features were correlated with Unified Parkinson Disease Rating Scale III evaluation. The same features were also investigated in patients with PD without surgery and healthy controls. Patients with Parkinson disease without surgery compared with healthy controls had a significantly lower average frequency and an increased average power in 1 to 48 Hz range in whole cortex. Higher relative power in theta and simultaneous decrease in beta and gamma over temporal and occipital were also observed in patients with PD. The Unified Parkinson Disease Rating Scale III rigidity score correlated with the average frequency and with the relative power of beta and gamma in frontal areas. During subthalamic nucleus deep brain stimulation, the average frequency increased significantly when stimulation was on compared with off state. In addition, the relative power dropped in delta, whereas it rose in beta over the whole cortex. Through the course of stimulation, the Unified Parkinson Disease Rating Scale III rigidity and tremor scores correlated with the relative power of alpha over left parietal. Subthalamic nucleus deep brain stimulation improves the symptoms of PD by suppressing the synchronization of alpha rhythm in somatomotor region.

  17. Processing of emotional information in the human subthalamic nucleus.

    PubMed

    Buot, Anne; Welter, Marie-Laure; Karachi, Carine; Pochon, Jean-Baptiste; Bardinet, Eric; Yelnik, Jérôme; Mallet, Luc

    2013-12-01

    The subthalamic nucleus (STN) is an efficient target for treating patients with Parkinson's disease as well as patients with obsessive-compulsive disorder (OCD) using high frequency stimulation (HFS). In both Parkinson's disease and OCD patients, STN-HFS can trigger abnormal behaviours, such as hypomania and impulsivity. To investigate if this structure processes emotional information, and whether it depends on motor demands, we recorded subthalamic local field potentials in 16 patients with Parkinson's disease using deep brain stimulation electrodes. Recordings were made with and without dopaminergic treatment while patients performed an emotional categorisation paradigm in which the response varied according to stimulus valence (pleasant, unpleasant and neutral) and to the instruction given (motor, non-motor and passive). Pleasant, unpleasant and neutral stimuli evoked an event related potential (ERP). Without dopamine medication, ERP amplitudes were significantly larger for unpleasant compared with neutral pictures, whatever the response triggered by the stimuli; and the magnitude of this effect was maximal in the ventral part of the STN. No significant difference in ERP amplitude was observed for pleasant pictures. With dopamine medication, ERP amplitudes were significantly increased for pleasant compared with neutral pictures whatever the response triggered by the stimuli, while ERP amplitudes to unpleasant pictures were not modified. These results demonstrate that the ventral part of the STN processes the emotional valence of stimuli independently of the motor context and that dopamine enhances processing of pleasant information. These findings confirm the specific involvement of the STN in emotional processes in human, which may underlie the behavioural changes observed in patients with deep brain stimulation.

  18. Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial.

    PubMed

    Lhommée, Eugénie; Wojtecki, Lars; Czernecki, Virginie; Witt, Karsten; Maier, Franziska; Tonder, Lisa; Timmermann, Lars; Hälbig, Thomas D; Pineau, Fanny; Durif, Franck; Witjas, Tatiana; Pinsker, Marcus; Mehdorn, Maximilian; Sixel-Döring, Friederike; Kupsch, Andreas; Krüger, Rejko; Elben, Saskia; Chabardès, Stephan; Thobois, Stéphane; Brefel-Courbon, Christine; Ory-Magne, Fabienne; Regis, Jean-Marie; Maltête, David; Sauvaget, Anne; Rau, Jörn; Schnitzler, Alfons; Schüpbach, Michael; Schade-Brittinger, Carmen; Deuschl, Gunther; Houeto, Jean-Luc; Krack, Paul

    2018-03-01

    Although subthalamic stimulation is a recognised treatment for motor complications in Parkinson's disease, reports on behavioural outcomes are controversial, which represents a major challenge when counselling candidates for subthalamic stimulation. We aimed to assess changes in behaviour in patients with Parkinson's disease receiving combined treatment with subthalamic stimulation and medical therapy over a 2-year follow-up period as compared with the behavioural evolution under medical therapy alone. We did a parallel, open-label study (EARLYSTIM) at 17 surgical centres in France (n=8) and Germany (n=9). We recruited patients with Parkinson's disease who were disabled by early motor complications. Participants were randomly allocated (1:1) to either medical therapy alone or bilateral subthalamic stimulation plus medical therapy. The primary outcome was mean change in quality of life from baseline to 2 years. A secondary analysis was also done to assess behavioural outcomes. We used the Ardouin Scale of Behavior in Parkinson's Disease to assess changes in behaviour between baseline and 2-year follow-up. Apathy was also measured using the Starkstein Apathy Scale, and depression was assessed with the Beck Depression Inventory. The secondary analysis was done in all patients recruited. We used a generalised estimating equations (GEE) regression model for individual items and mixed model regression for subscores of the Ardouin scale and the apathy and depression scales. This trial is registered with ClinicalTrials.gov, number NCT00354133. The primary analysis has been reported elsewhere; this report presents the secondary analysis only. Between July, 2006, and November, 2009, 251 participants were recruited, of whom 127 were allocated medical therapy alone and 124 were assigned bilateral subthalamic stimulation plus medical therapy. At 2-year follow-up, the levodopa-equivalent dose was reduced by 39% (-363·3 mg/day [SE 41·8]) in individuals allocated bilateral

  19. Strong Evidence for Stochastic Growth of Langmuir-Like Waves in Earth's Foreshock

    NASA Technical Reports Server (NTRS)

    Cairns, Iver H.; Robinson, P. A.

    1999-01-01

    Bursty Langmuir-like waves driven by electron beams in Earth's foreshock have properties which are inconsistent with the standard plasma physics paradigm of uniform exponential growth saturated by nonlinear processes. Here it is demonstrated for a specific period that stochastic growth theory (SGT) quantitatively describes these waves throughout a large fraction of the foreshock. The statistical wave properties are inconsistent with nonlinear processes or self-organized criticality being important. SGT's success in explaining the foreshock waves and type III solar bursts suggests that SGT is widely applicable to wave growth in space, astrophysical, and laboratory plasmas.

  20. Sensory contribution to vocal emotion deficit in Parkinson's disease after subthalamic stimulation.

    PubMed

    Péron, Julie; Cekic, Sezen; Haegelen, Claire; Sauleau, Paul; Patel, Sona; Drapier, Dominique; Vérin, Marc; Grandjean, Didier

    2015-02-01

    Subthalamic nucleus (STN) deep brain stimulation in Parkinson's disease induces modifications in the recognition of emotion from voices (or emotional prosody). Nevertheless, the underlying mechanisms are still only poorly understood, and the role of acoustic features in these deficits has yet to be elucidated. Our aim was to identify the influence of acoustic features on changes in emotional prosody recognition following STN stimulation in Parkinson's disease. To this end, we analysed the performances of patients on vocal emotion recognition in pre-versus post-operative groups, as well as of matched controls, entering the acoustic features of the stimuli into our statistical models. Analyses revealed that the post-operative biased ratings on the Fear scale when patients listened to happy stimuli were correlated with loudness, while the biased ratings on the Sadness scale when they listened to happiness were correlated with fundamental frequency (F0). Furthermore, disturbed ratings on the Happiness scale when the post-operative patients listened to sadness were found to be correlated with F0. These results suggest that inadequate use of acoustic features following subthalamic stimulation has a significant impact on emotional prosody recognition in patients with Parkinson's disease, affecting the extraction and integration of acoustic cues during emotion perception. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease

    PubMed Central

    Neumann, Wolf-Julian; Bock, Antje; Horn, Andreas; Huebl, Julius; Siegert, Sandy; Schneider, Gerd-Helge; Krauss, Joachim K

    2018-01-01

    Gamma synchronization increases during movement and scales with kinematic parameters. Here, disease-specific characteristics of this synchronization and the dopamine-dependence of its scaling in Parkinson’s disease are investigated. In 16 patients undergoing deep brain stimulation surgery, movements of different velocities revealed that subthalamic gamma power peaked in the sensorimotor part of the subthalamic nucleus, correlated positively with maximal velocity and negatively with symptom severity. These effects relied on movement-related bursts of transient synchrony in the gamma band. The gamma burst rate highly correlated with averaged power, increased gradually with larger movements and correlated with symptom severity. In the dopamine-depleted state, gamma power and burst rate significantly decreased, particularly when peak velocity was slower than ON medication. Burst amplitude and duration were unaffected by the medication state. We propose that insufficient recruitment of fast gamma bursts during movement may underlie bradykinesia as one of the cardinal symptoms in Parkinson’s disease. PMID:29388913

  2. Normalizing motor-related brain activity: subthalamic nucleus stimulation in Parkinson disease.

    PubMed

    Grafton, S T; Turner, R S; Desmurget, M; Bakay, R; Delong, M; Vitek, J; Crutcher, M

    2006-04-25

    To test whether therapeutic unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson disease (PD) leads to normalization in the pattern of brain activation during movement execution and control of movement extent. Six patients with PD were imaged off medication by PET during performance of a visually guided tracking task with the DBS voltage programmed for therapeutic (effective) or subtherapeutic (ineffective) stimulation. Data from patients with PD during ineffective stimulation were compared with a group of 13 age-matched control subjects to identify sites with abnormal patterns of activation. Conjunction analysis was used to identify those areas in patients with PD where activity normalized when they were treated with effective stimulation. For movement execution, effective DBS caused an increase of activation in the supplementary motor area (SMA), superior parietal cortex, and cerebellum toward a more normal pattern. At rest, effective stimulation reduced overactivity of SMA. Therapeutic stimulation also induced reductions of movement related "overactivity" compared with healthy subjects in prefrontal, temporal lobe, and basal ganglia circuits, consistent with the notion that many areas are recruited to compensate for ineffective motor initiation. Normalization of activity related to the control of movement extent was associated with reductions of activity in primary motor cortex, SMA, and basal ganglia. Effective subthalamic nucleus stimulation leads to task-specific modifications with appropriate recruitment of motor areas as well as widespread, nonspecific reductions of compensatory or competing cortical activity.

  3. Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys

    PubMed Central

    Deffains, Marc; Iskhakova, Liliya; Katabi, Shiran; Haber, Suzanne N; Israel, Zvi; Bergman, Hagai

    2016-01-01

    The striatum and the subthalamic nucleus (STN) constitute the input stage of the basal ganglia (BG) network and together innervate BG downstream structures using GABA and glutamate, respectively. Comparison of the neuronal activity in BG input and downstream structures reveals that subthalamic, not striatal, activity fluctuations correlate with modulations in the increase/decrease discharge balance of BG downstream neurons during temporal discounting classical condition task. After induction of parkinsonism with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), abnormal low beta (8-15 Hz) spiking and local field potential (LFP) oscillations resonate across the BG network. Nevertheless, LFP beta oscillations entrain spiking activity of STN, striatal cholinergic interneurons and BG downstream structures, but do not entrain spiking activity of striatal projection neurons. Our results highlight the pivotal role of STN divergent projections in BG physiology and pathophysiology and may explain why STN is such an effective site for invasive treatment of advanced Parkinson's disease and other BG-related disorders. DOI: http://dx.doi.org/10.7554/eLife.16443.001 PMID:27552049

  4. Magnetic resonance imaging of the subthalamic nucleus for deep brain stimulation.

    PubMed

    Chandran, Arjun S; Bynevelt, Michael; Lind, Christopher R P

    2016-01-01

    The subthalamic nucleus (STN) is one of the most important stereotactic targets in neurosurgery, and its accurate imaging is crucial. With improving MRI sequences there is impetus for direct targeting of the STN. High-quality, distortion-free images are paramount. Image reconstruction techniques appear to show the greatest promise in balancing the issue of geometrical distortion and STN edge detection. Existing spin echo- and susceptibility-based MRI sequences are compared with new image reconstruction methods. Quantitative susceptibility mapping is the most promising technique for stereotactic imaging of the STN.

  5. Stridor and dysphagia associated with subthalamic nucleus stimulation in Parkinson disease.

    PubMed

    Fagbami, Oluwakemi Y; Donato, Anthony A

    2011-11-01

    Refractory symptoms in Parkinson disease show good response to deep brain stimulation (DBS). This procedure improves United Parkinson's Disease Rating Scale scores and reduces dyskinesias, whereas speech and swallowing dysfunction typically do not improve and may even worsen. Rarely, DBS can cause idiosyncratic dystonias of muscle groups, including those of the neck and throat. The authors describe a patient experiencing stridor and dysphagia with confirmed pulmonary restriction and aspiration following subthalamic nucleus deep brain stimulator adjustment, with a resolution of symptoms and signs when the stimulator was switched off.

  6. High performance of poly(dopamine)-functionalized graphene oxide/poly(vinyl alcohol) nanocomposites

    NASA Astrophysics Data System (ADS)

    Ma, Jiaojiao; Pan, Jingkai; Yue, Jia; Xu, Yu; Bao, Jianjun

    2018-01-01

    In this paper, poly(vinyl alcohol) (PVA)/poly(dopamine)-functionalized graphene oxide (PGO) nanocomposites with high performance were prepared by an environment-friendly and facile strategy. GO was firstly functionalized and simultaneously reduced by poly(dopamine) to yield PGO. Then it was mixed with PVA in aqueous solution to make PVA/PGO nanocomposites. Transmission electron microscopy revealed that the PGO nanosheets are well dispersed and randomly oriented throughout the PVA matrix. At the same time, the thermal properties and water barrier properties of the PVA/PGO nanocomposites have been strikingly enhanced by the incorporation of PGO. The degradation temperature of the nanocomposites is more than 30 °C higher than that of pure PVA by the addition of 0.7 wt% PGO, which shows good thermal stability. The water vapor permeability of the nanocomposites also decreases to 0.71 × 10-12 g cm/(cm2 s Pa), corresponding to 80% reduction than that of pure PVA. Moreover, the PVA/PGO nanocomposites also present enhanced conductive properties. The PVA/PGO nanocomposites with such outstanding properties show great promising applications in the fields of packaging, electronics, fuel cell industry, fiber, and so on.

  7. Rough wave-like heaped overburden promotes establishment of woody vegetation while leveling promotes grasses during unassisted post mining site development.

    PubMed

    Frouz, Jan; Mudrák, Ondřej; Reitschmiedová, Erika; Walmsley, Alena; Vachová, Pavla; Šimáčková, Hana; Albrechtová, Jana; Moradi, Jabbar; Kučera, Jiří

    2018-01-01

    Geodiversity plays an important role in species establishment during spontaneous succession. At post-mining sites in the Czech Republic in 2003, we established plots in which the surface of the heaped overburden was either kept wave-like or leveled. Based on surveys conducted from 2006 to 2015, leveled plots were increasingly dominated by grasses and herbs (and especially by the grass Calamagrostis epigejos) while the wave-like plots were increasingly dominated by the trees Salix caprea and Betula pendula. In 2015, a detailed survey was conducted of the dominant species. Both S. caprea and B. pendula occurred more often in wave-like plots than in leveled plots; this was particularly true for trees taller than 1 m, which were absent in leveled plots. In wave-like plots, leaf and root biomasses of both woody species were higher on the wave slopes than on the wave depressions. Nitrogen content was higher but content stress indicating proline in leaves of S. caprea was lower in wave-like plots than in leveled plots. In wave-like plots, both woody species occurred mainly on wave slopes but C. epigejos occurred mainly in the depressions. We speculate that trees were more abundant in wave-like plots than in leveled plots because the waves trapped tree seeds and snow and because the soil porosity was greater in wave-like than in leveled plots. Grasses may have preferred the leveled plots because soil porosity was lower and clay content was higher in leveled than in wave-like plots. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Sensory contribution to vocal emotion deficit in Parkinson’s disease after subthalamic stimulation

    PubMed Central

    Péron, Julie; Cekic, Sezen; Haegelen, Claire; Sauleau, Paul; Patel, Sona; Drapier, Dominique; Vérin, Marc; Grandjean, Didier

    2016-01-01

    Subthalamic nucleus (STN) deep brain stimulation in Parkinson’s disease induces modifications in the recognition of emotion from voices (or emotional prosody). Nevertheless, the underlying mechanisms are still only poorly understood, and the role of acoustic features in these deficits has yet to be elucidated. Our aim was to identify the influence of acoustic features on changes in emotional prosody recognition following STN stimulation in Parkinson’s disease. To this end, we analysed the performances of patients on vocal emotion recognition in pre-versus post-operative groups, as well as of matched controls, entering the acoustic features of the stimuli into our statistical models. Analyses revealed that the post-operative biased ratings on the Fear scale when patients listened to happy stimuli were correlated with loudness, while the biased ratings on the Sadness scale when they listened to happiness were correlated with fundamental frequency (F0). Furthermore, disturbed ratings on the Happiness scale when the post-operative patients listened to sadness were found to be correlated with F0. These results suggest that inadequate use of acoustic features following subthalamic stimulation has a significant impact on emotional prosody recognition in patients with Parkinson’s disease, affecting the extraction and integration of acoustic cues during emotion perception. PMID:25282055

  9. Reduction of susceptibility-induced signal losses in multi-gradient-echo images: application to improved visualization of the subthalamic nucleus.

    PubMed

    Volz, Steffen; Hattingen, Elke; Preibisch, Christine; Gasser, Thomas; Deichmann, Ralf

    2009-05-01

    T2-weighted gradient echo (GE) images yield good contrast of iron-rich structures like the subthalamic nuclei due to microscopic susceptibility induced field gradients, providing landmarks for the exact placement of deep brain stimulation electrodes in Parkinson's disease treatment. An additional advantage is the low radio frequency (RF) exposure of GE sequences. However, T2-weighted images are also sensitive to macroscopic field inhomogeneities, resulting in signal losses, in particular in orbitofrontal and temporal brain areas, limiting anatomical information from these areas. In this work, an image correction method for multi-echo GE data based on evaluation of phase information for field gradient mapping is presented and tested in vivo on a 3 Tesla whole body MR scanner. In a first step, theoretical signal losses are calculated from the gradient maps and a pixelwise image intensity correction is performed. In a second step, intensity corrected images acquired at different echo times TE are combined using optimized weighting factors: in areas not affected by macroscopic field inhomogeneities, data acquired at long TE are weighted more strongly to achieve the contrast required. For large field gradients, data acquired at short TE are favored to avoid signal losses. When compared to the original data sets acquired at different TE and the respective intensity corrected data sets, the resulting combined data sets feature reduced signal losses in areas with major field gradients, while intensity profiles and a contrast-to-noise (CNR) analysis between subthalamic nucleus, red nucleus and the surrounding white matter demonstrate good contrast in deep brain areas.

  10. Efficient simultaneous adsorption-biodegradation of high-concentrated N,N-dimethylformamide from water by Paracoccus denitrificans-graphene oxide microcomposites

    NASA Astrophysics Data System (ADS)

    Zheng, Yuan; Chen, Dongyun; Li, Najun; Xu, Qingfeng; Li, Hua; He, Jinghui; Lu, Jianmei

    2016-02-01

    Water contamination becomes one of the most pervasive environmental issues all over the world in recent years. In this paper, the functionalization of graphene oxide (GO) with copolymers containing methacrylic acid (MAA) and butyl methacrylate (BMA) was investigated to prepare a new microcomposite material (PGO) via free radical solution polymerization. PGO was used for the adsorption of N,N-dimethylformamide (DMF) from aqueous solution by utilizing the characteristics of ultralarge surface and the Van der Waals force between DMF molecules and polymers on the surface of PGO. Besides, PGO was used not only a high-capable adsorbent but also a carrier for the immobilization of Paracoccus denitrificans cells in the treatment of high-concentrated DMF. Bacterial cells could immobilized on the PGO (PGO@P. denitrificans) stably by covalent coupling process after acclimatization and high-concentrated DMF (2000 mg/L) could be removed completely and relatively rapidly from aqueous solutions by the simultaneous adsorption-biodegradation (SAB) process of PGO@P. denitrificans. Furthermore, the excellent recycle performance of PGO@P. denitrificans made the whole process more economical and practical.

  11. Sensitivity analysis of discharge patterns of subthalamic nucleus in the model of basal ganglia in Parkinson disease.

    PubMed

    Singh, Jyotsna; Singh, Phool; Malik, Vikas

    2017-01-01

    Parkinson disease alters the information patterns in movement related pathways in brain. Experimental results performed on rats show that the activity patterns changes from single spike activity to mixed burst mode in Parkinson disease. However the cause of this change in activity pattern is not yet completely understood. Subthalamic nucleus is one of the main nuclei involved in the origin of motor dysfunction in Parkinson disease. In this paper, a single compartment conductance based model is considered which focuses on subthalamic nucleus and synaptic input from globus pallidus (external). This model shows highly nonlinear behavior with respect to various intrinsic parameters. Behavior of model has been presented with the help of activity patterns generated in healthy and Parkinson condition. These patterns have been compared by calculating their correlation coefficient for different values of intrinsic parameters. Results display that the activity patterns are very sensitive to various intrinsic parameters and calcium shows some promising results which provide insights into the motor dysfunction.

  12. Direct observation and imaging of a spin-wave soliton with p-like symmetry

    NASA Astrophysics Data System (ADS)

    Bonetti, S.; Kukreja, R.; Chen, Z.; Macià, F.; Hernàndez, J. M.; Eklund, A.; Backes, D.; Frisch, J.; Katine, J.; Malm, G.; Urazhdin, S.; Kent, A. D.; Stöhr, J.; Ohldag, H.; Dürr, H. A.

    2015-11-01

    Spin waves, the collective excitations of spins, can emerge as nonlinear solitons at the nanoscale when excited by an electrical current from a nanocontact. These solitons are expected to have essentially cylindrical symmetry (that is, s-like), but no direct experimental observation exists to confirm this picture. Using a high-sensitivity time-resolved magnetic X-ray microscopy with 50 ps temporal resolution and 35 nm spatial resolution, we are able to create a real-space spin-wave movie and observe the emergence of a localized soliton with a nodal line, that is, with p-like symmetry. Micromagnetic simulations explain the measurements and reveal that the symmetry of the soliton can be controlled by magnetic fields. Our results broaden the understanding of spin-wave dynamics at the nanoscale, with implications for the design of magnetic nanodevices.

  13. Bloch-like waves in random-walk potentials based on supersymmetry

    NASA Astrophysics Data System (ADS)

    Yu, Sunkyu; Piao, Xianji; Hong, Jiho; Park, Namkyoo

    2015-09-01

    Bloch's theorem was a major milestone that established the principle of bandgaps in crystals. Although it was once believed that bandgaps could form only under conditions of periodicity and long-range correlations for Bloch's theorem, this restriction was disproven by the discoveries of amorphous media and quasicrystals. While network and liquid models have been suggested for the interpretation of Bloch-like waves in disordered media, these approaches based on searching for random networks with bandgaps have failed in the deterministic creation of bandgaps. Here we reveal a deterministic pathway to bandgaps in random-walk potentials by applying the notion of supersymmetry to the wave equation. Inspired by isospectrality, we follow a methodology in contrast to previous methods: we transform order into disorder while preserving bandgaps. Our approach enables the formation of bandgaps in extremely disordered potentials analogous to Brownian motion, and also allows the tuning of correlations while maintaining identical bandgaps, thereby creating a family of potentials with `Bloch-like eigenstates'.

  14. The MDS-UPDRS tracks motor and non-motor improvement due to subthalamic nucleus deep brain stimulation in Parkinson disease.

    PubMed

    Chou, Kelvin L; Taylor, Jennifer L; Patil, Parag G

    2013-11-01

    The Movement Disorders Society revision of the Unified Parkinson Disease Rating Scale (MDS-UPDRS) improves upon the original UPDRS by adding more non-motor items, making it a more robust tool to evaluate the severity of motor and non-motor symptoms of Parkinson disease. Previous studies on deep brain stimulation have not used the MDS-UPDRS. To determine if the MDS-UPDRS could detect improvement in both motor and non-motor symptoms after bilateral subthalamic nucleus deep brain stimulation for Parkinson disease. We compared scores on the entire MDS-UPDRS prior to surgery (baseline) and approximately six months following the initial programming visit in twenty subjects (12M/8F) with Parkinson disease undergoing bilateral subthalamic nucleus deep brain stimulation. STN DBS significantly improved the scores for every section of the MDS-UPDRS at the 6 month follow-up. Part I improved by 3.1 points (22%), Part II by 5.3 points (29%), Part III by 13.1 points (29%) with stimulation alone, and Part IV by 7.1 points (74%). Individual non-motor items in Part I that improved significantly were constipation, light-headedness, and fatigue. Both motor and non-motor symptoms, as assessed by the MDS-UPDRS, improve with bilateral subthalamic nucleus stimulation six months after the stimulator is turned on. We recommend that the MDS-UPDRS be utilized in future deep brain stimulation studies because of the advantage of detecting change in non-motor symptoms. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with symptoms severity and predicts high-frequency stimulation efficacy.

    PubMed

    Welter, M-L; Burbaud, P; Fernandez-Vidal, S; Bardinet, E; Coste, J; Piallat, B; Borg, M; Besnard, S; Sauleau, P; Devaux, B; Pidoux, B; Chaynes, P; Tézenas du Montcel, S; Bastian, A; Langbour, N; Teillant, A; Haynes, W; Yelnik, J; Karachi, C; Mallet, L

    2011-05-03

    Functional and connectivity changes in corticostriatal systems have been reported in the brains of patients with obsessive-compulsive disorder (OCD); however, the relationship between basal ganglia activity and OCD severity has never been adequately established. We recently showed that deep brain stimulation of the subthalamic nucleus (STN), a central basal ganglia nucleus, improves OCD. Here, single-unit subthalamic neuronal activity was analysed in 12 OCD patients, in relation to the severity of obsessions and compulsions and response to STN stimulation, and compared with that obtained in 12 patients with Parkinson's disease (PD). STN neurons in OCD patients had lower discharge frequency than those in PD patients, with a similar proportion of burst-type activity (69 vs 67%). Oscillatory activity was present in 46 and 68% of neurons in OCD and PD patients, respectively, predominantly in the low-frequency band (1-8 Hz). In OCD patients, the bursty and oscillatory subthalamic neuronal activity was mainly located in the associative-limbic part. Both OCD severity and clinical improvement following STN stimulation were related to the STN neuronal activity. In patients with the most severe OCD, STN neurons exhibited bursts with shorter duration and interburst interval, but higher intraburst frequency, and more oscillations in the low-frequency bands. In patients with best clinical outcome with STN stimulation, STN neurons displayed higher mean discharge, burst and intraburst frequencies, and lower interburst interval. These findings are consistent with the hypothesis of a dysfunction in the associative-limbic subdivision of the basal ganglia circuitry in OCD's pathophysiology.

  16. Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo.

    PubMed

    Chhatbar, Pratik Y; Kautz, Steven A; Takacs, Istvan; Rowland, Nathan C; Revuelta, Gonzalo J; George, Mark S; Bikson, Marom; Feng, Wuwei

    2018-03-13

    Transcranial direct current stimulation (tDCS) is a promising brain modulation technique for several disease conditions. With this technique, some portion of the current penetrates through the scalp to the cortex and modulates cortical excitability, but a recent human cadaver study questions the amount. This insufficient intracerebral penetration of currents may partially explain the inconsistent and mixed results in tDCS studies to date. Experimental validation of a transcranial alternating current stimulation-generated electric field (EF) in vivo has been performed on the cortical (using electrocorticography, ECoG, electrodes), subcortical (using stereo electroencephalography, SEEG, electrodes) and deeper thalamic/subthalamic levels (using DBS electrodes). However, tDCS-generated EF measurements have never been attempted. We aimed to demonstrate that tDCS generates biologically relevant EF as deep as the subthalamic level in vivo. Patients with movement disorders who have implanted deep brain stimulation (DBS) electrodes serve as a natural experimental model for thalamic/subthalamic recordings of tDCS-generated EF. We measured voltage changes from DBS electrodes and body resistance from tDCS electrodes in three subjects while applying direct current to the scalp at 2 mA and 4 mA over two tDCS montages. Voltage changes at the level of deep nuclei changed proportionally with the level of applied current and varied with different tDCS montages. Our findings suggest that scalp-applied tDCS generates biologically relevant EF. Incorporation of these experimental results may improve finite element analysis (FEA)-based models. Copyright © 2018 Elsevier Inc. All rights reserved.

  17. Intensive Voice Treatment (LSVT[R]LOUD) for Parkinson's Disease Following Deep Brain Stimulation of the Subthalamic Nucleus

    ERIC Educational Resources Information Center

    Spielman, Jennifer; Mahler, Leslie; Halpern, Angela; Gilley, Phllip; Klepitskaya, Olga; Ramig, Lorraine

    2011-01-01

    Purpose: Intensive voice therapy (LSVT[R]LOUD) can effectively manage voice and speech symptoms associated with idiopathic Parkinson disease (PD). This small-group study evaluated voice and speech in individuals with and without deep brain stimulation of the subthalamic nucleus (STN-DBS) before and after LSVT LOUD, to determine whether outcomes…

  18. Effects of Stimulation of the Subthalamic Nucleus on Naming and Reading Nouns and Verbs in Parkinson's Disease

    ERIC Educational Resources Information Center

    Silveri, Maria Caterina; Ciccarelli, Nicoletta; Baldonero, Eleonora; Piano, Carla; Zinno, Massimiliano; Soleti, Francesco; Bentivoglio, Anna Rita; Albanese, Alberto; Daniele, Antonio

    2012-01-01

    An impairment for verbs has been described in patients with Parkinson's disease (PD), suggesting that a disruption of frontal-subcortical circuits may result in dysfunction of the neural systems involved in action-verb processing. A previous study suggested that deep brain stimulation (DBS) of the subthalamic nucleus (STN) during verb generation…

  19. The impact of Parkinson's disease and subthalamic deep brain stimulation on reward processing.

    PubMed

    Evens, Ricarda; Stankevich, Yuliya; Dshemuchadse, Maja; Storch, Alexander; Wolz, Martin; Reichmann, Heinz; Schlaepfer, Thomas E; Goschke, Thomas; Lueken, Ulrike

    2015-08-01

    Due to its position in cortico-subthalamic and cortico-striatal pathways, the subthalamic nucleus (STN) is considered to play a crucial role not only in motor, but also in cognitive and motivational functions. In the present study we aimed to characterize how different aspects of reward processing are affected by disease and deep brain stimulation of the STN (DBS-STN) in patients with idiopathic Parkinson's disease (PD). We compared 33 PD patients treated with DBS-STN under best medical treatment (DBS-on, medication-on) to 33 PD patients without DBS, but optimized pharmacological treatment and 34 age-matched healthy controls. We then investigated DBS-STN effects using a postoperative stimulation-on/ -off design. The task set included a delay discounting task, a task to assess changes in incentive salience attribution, and the Iowa Gambling Task. The presence of PD was associated with increased incentive salience attribution and devaluation of delayed rewards. Acute DBS-STN increased risky choices in the Iowa Gambling Task under DBS-on condition, but did not further affect incentive salience attribution or the evaluation of delayed rewards. Findings indicate that acute DBS-STN affects specific aspects of reward processing, including the weighting of gains and losses, while larger-scale effects of disease or medication are predominant in others reward-related functions. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Persistent suppression of subthalamic beta-band activity during rhythmic finger tapping in Parkinson's disease.

    PubMed

    Joundi, Raed A; Brittain, John-Stuart; Green, Alex L; Aziz, Tipu Z; Brown, Peter; Jenkinson, Ned

    2013-03-01

    The function of synchronous oscillatory activity at beta band (15-30Hz) frequencies within the basal ganglia is unclear. Here we sought support for the hypothesis that beta activity has a global function within the basal ganglia and is not directly involved in the coding of specific biomechanical parameters of movement. We recorded local field potential activity from the subthalamic nuclei of 11 patients with Parkinson's disease during a synchronized tapping task at three different externally cued rates. Beta activity was suppressed during tapping, reaching a minimum that differed little across the different tapping rates despite an increase in velocity of finger movements. Thus beta power suppression was independent of specific motor parameters. Moreover, although beta oscillations remained suppressed during all tapping rates, periods of resynchronization between taps were markedly attenuated during high rate tapping. As such, a beta rebound above baseline between taps at the lower rates was absent at the high rate. Our results demonstrate that beta desynchronization in the region of the subthalamic nucleus is independent of motor parameters and that the beta resynchronization is differentially modulated by rate of finger tapping, These findings implicate consistent beta suppression in the facilitation of continuous movement sequences. Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  1. Direct observation and imaging of a spin-wave soliton with p-like symmetry

    DOE PAGES

    Bonetti, S.; Kukreja, R.; Chen, Z.; ...

    2015-11-16

    Spin waves, the collective excitations of spins, can emerge as nonlinear solitons at the nanoscale when excited by an electrical current from a nanocontact. These solitons are expected to have essentially cylindrical symmetry (that is, s-like), but no direct experimental observation exists to confirm this picture. Using a high-sensitivity time-resolved magnetic X-ray microscopy with 50 ps temporal resolution and 35 nm spatial resolution, we are able to create a real-space spin-wave movie and observe the emergence of a localized soliton with a nodal line, that is, with p-like symmetry. Moreover, micromagnetic simulations explain the measurements and reveal that the symmetrymore » of the soliton can be controlled by magnetic fields. Our results broaden the understanding of spin-wave dynamics at the nanoscale, with implications for the design of magnetic nanodevices.« less

  2. Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease.

    PubMed

    Benis, Damien; David, Olivier; Piallat, Brigitte; Kibleur, Astrid; Goetz, Laurent; Bhattacharjee, Manik; Fraix, Valérie; Seigneuret, Eric; Krack, Paul; Chabardès, Stéphan; Bastin, Julien

    2016-11-01

    The subthalamic nucleus (STN) plays a critical role during action inhibition, perhaps by acting like a fast brake on the motor system when inappropriate responses have to be rapidly suppressed. However, the mechanisms involving the STN during motor inhibition are still unclear, particularly because of a relative lack of single-cell responses reported in this structure in humans. In this study, we used extracellular microelectrode recordings during deep brain stimulation surgery in patients with Parkinson's disease (PD) to study STN neurophysiological correlates of inhibitory control during a stop signal task. We found two neuronal subpopulations responding either during motor execution (GO units) or during motor inhibition (STOP units). GO units fired selectively before patients' motor responses whereas STOP units fired selectively when patients successfully withheld their move at a latency preceding the duration of the inhibition process. These results provide electrophysiological evidence for the hypothesized role of the STN in current models of response inhibition. Copyright © 2016. Published by Elsevier Ltd.

  3. Higher-order rogue wave-like solutions for a nonautonomous nonlinear Schrödinger equation with external potentials

    NASA Astrophysics Data System (ADS)

    Liu, Lei; Tian, Bo; Wu, Xiao-Yu; Sun, Yan

    2018-02-01

    Under investigation in this paper is the higher-order rogue wave-like solutions for a nonautonomous nonlinear Schrödinger equation with external potentials which can be applied in the nonlinear optics, hydrodynamics, plasma physics and Bose-Einstein condensation. Based on the Kadomtsev-Petviashvili hierarchy reduction, we construct the Nth order rogue wave-like solutions in terms of the Gramian under the integrable constraint. With the help of the analytic and graphic analysis, we exhibit the first-, second- and third-order rogue wave-like solutions through the different dispersion, nonlinearity and linear potential coefficients. We find that only if the dispersion and nonlinearity coefficients are proportional to each other, heights of the background of those rogue waves maintain unchanged with time increasing. Due to the existence of complex parameters, such nonautonomous rogue waves in the higher-order cases have more complex features than those in the lower.

  4. Numerical Investigation of Shock Wave Propagation in Bone-Like Tissue

    NASA Astrophysics Data System (ADS)

    Nelms, Matt; Rajendran, Arunachalam

    In this investigation, the effects of shock wave propagation in bone-like biomineralized tissue was investigated. The Alligator gar (Atractosteus spatula) exoskeleton is comprised of many disparate scales that provide a biological analog for potential design of flexible protective material systems. The penetration resistant fish scale was modeled by simulating a plate impact test configuration using ABAQUS®finite element (FE) software. The gar scale is identified as a two-phase, (1) hydroxyapatite mineral and (2) collagen protein, biological composite with two distinct layers where a stiff, ceramic-like ganoine overlays a soft, highly ductile bone. The geometry and variation of elastic modulus were determined from high-resolution scanning electron microscopy and dynamic nanoindentation experimentation to develop an idealized computational model for RVE-based FE simulations. The numerical analysis shows the effects of different functional material property variations on the stress histories and energy dissipation generated by wave propagation. Given the constitutive behaviors of the two layers are distinctly different, a brittle tensile damage model was employed to describe the ganoine and Drucker-Prager plasticity was used for the nonlinear response of the bone.

  5. Relativistic distorted-wave collision strengths for Δn = 0 transitions in the 67 Li-like, F-like and Na-like ions with 26 ≤ Z ≤ 92

    NASA Astrophysics Data System (ADS)

    Fontes, Christopher J.; Zhang, Hong Lin

    2017-01-01

    Relativistic distorted-wave collision strengths have been calculated for all possible Δn = 0 transitions, where n denotes the valence shell of the ground level, in the 67 Li-like, F-like and Na-like ions with Z in the range 26 ≤ Z ≤ 92. This choice produces 3 transitions with n = 2 in the Li-like and F-like ions, and 10 transitions with n = 3 in the Na-like ions. For the Li-like and F-like ions, the calculations were made for the six final, or scattered, electron energies E‧ = 0.008 , 0.04 , 0.10 , 0.21 , 0.41, and 0.75, where E‧ is in units of Zeff2 Ry with Zeff = Z - 1.66 for Li-like ions and Zeff = Z - 6.667 for F-like ions. For the Na-like ions, the calculations were made for the six final electron energies E‧ = 0.0025 , 0.015 , 0.04 , 0.10 , 0.21, and 0.40, with Zeff = Z - 8.34. In the present calculations, an improved "top-up" method, which employs relativistic plane waves, was used to obtain the high partial-wave contribution for each transition, in contrast to the partial-relativistic Coulomb-Bethe approximation used in previous works by Zhang, Sampson and Fontes [H.L. Zhang, D.H. Sampson, C.J. Fontes, At. Data Nucl. Data Tables 44 (1990) 31; H.L. Zhang, D.H. Sampson, C.J. Fontes, At. Data Nucl. Data Tables 48 (1991) 25; D.H. Sampson, H.L. Zhang, C.J. Fontes, At. Data Nucl. Data Tables 44 (1990) 209]. In those previous works, collision strengths were also provided for Li-, F- and Na-like ions, but for a more comprehensive set of transitions. The collision strengths covered in the present work should be more accurate than the corresponding data given in those previous works and are presented here to replace those earlier results.

  6. Relativistic distorted-wave collision strengths for Δn = 0 transitions in the 67 Li-like, F-like and Na-like ions with 26 ≤ Z ≤ 92

    DOE PAGES

    Fontes, Christopher J.; Zhang, Hong Lin

    2017-01-01

    We calculated relativistic distorted-wave collision strength for all possible Δn=0 transitions, where n denotes the valence shell of the ground level, in the 67 Li-like, F-like and Na-like ions with Z in the range 26 ≤ Z ≤92. This choice produces 3 transitions with n=2 in the Li-like and F-like ions, and 10 transitions with n=3 in the Na-like ions. Moreover, for the Li-like and F-like ions, the calculations were made for the six final, or scattered, electron energies E'=0.008,0.04,0.10,0.21,0.41, and 0.75, where E' is in units of Zmore » $$2\\atop{eff}$$ Ry with Z eff = Z- 1.66 for Li-like ions and Z eff= Z- 6.667 for F-like ions. For the Na-like ions, the calculations were made for the six final electron energies E'=0.0025,0.015,0.04,0.10,0.21, and 0.40, with Z eff = Z- 8.34. In the present calculations, an improved “top-up” method, which employs relativistic plane waves, was used to obtain the high partial-wave contribution for each transition, in contrast to the partial-relativistic Coulomb–Bethe approximation used in previous works by Zhang, Sampson and Fontes [H.L. Zhang, D.H. Sampson, C.J. Fontes, At. Data Nucl. Data Tables 44 (1990) 31; H.L. Zhang, D.H. Sampson, C.J. Fontes, At. Data Nucl. Data Tables 48 (1991) 25; D.H. Sampson, H.L. Zhang, C.J. Fontes, At. Data Nucl. Data Tables 44 (1990) 209]. In those previous works, collision strengths were also provided for Li-, F- and Na-like ions, but for a more comprehensive set of transitions. Finally, the collision strengths covered in the present work should be more accurate than the corresponding data given in those previous works and are presented here to replace those earlier results.« less

  7. Subthalamic nucleus long-range synchronization—an independent hallmark of human Parkinson's disease

    PubMed Central

    Moshel, Shay; Shamir, Reuben R.; Raz, Aeyal; de Noriega, Fernando R.; Eitan, Renana; Bergman, Hagai; Israel, Zvi

    2013-01-01

    Beta-band synchronous oscillations in the dorsolateral region of the subthalamic nucleus (STN) of human patients with Parkinson's disease (PD) have been frequently reported. However, the correlation between STN oscillations and synchronization has not been thoroughly explored. The simultaneous recordings of 2390 multi-unit pairs recorded by two parallel microelectrodes (separated by fixed distance of 2 mm, n = 72 trajectories with two electrode tracks >4 mm STN span) in 57 PD patients undergoing STN deep brain stimulation surgery were analyzed. Automatic procedures were utilized to divide the STN into dorsolateral oscillatory and ventromedial non-oscillatory regions, and to quantify the intensity of STN oscillations and synchronicity. Finally, the synchronicity of simultaneously vs. non-simultaneously recorded pairs were compared using a shuffling procedure. Synchronization was observed predominately in the beta range and only between multi-unit pairs in the dorsolateral oscillatory region (n = 615). In paired recordings between sites in the dorsolateral and ventromedial (n = 548) and ventromedial-ventromedial region pairs (n = 1227), no synchronization was observed. Oscillation and synchronicity intensity decline along the STN dorsolateral-ventromedial axis suggesting a fuzzy border between the STN regions. Synchronization strength was significantly correlated to the oscillation power, but synchronization was no longer observed following shuffling. We conclude that STN long-range beta oscillatory synchronization is due to increased neuronal coupling in the Parkinsonian brain and does not merely reflect the outcome of oscillations at similar frequency. The neural synchronization in the dorsolateral (probably the motor domain) STN probably augments the pathological changes in firing rate and patterns of subthalamic neurons in PD patients. PMID:24312018

  8. Comprehensive Prediction of Large-height Swell-like Waves in East Coast of Korea

    NASA Astrophysics Data System (ADS)

    Kwon, S. J.; Lee, C.; Ahn, S. J.; Kim, H. K.

    2014-12-01

    There have been growing interests in the large-height swell-like wave (LSW) in the east coast of Korea because such big waves have caused human victims as well as damages to facilities such as breakwaters in the coast. The LSW was found to be generated due to an atmospherically great valley in the north area of the East Sea and then propagate long distance to the east coast of Korea in prominently southwest direction (Oh et al., 2010).In this study, we will perform two methods, real-time data based and numerical-model based predictions in order to predict the LSW in the east coast of Korea. First, the real-time data based prediction method uses information which is collected by the directional wave gauge installed near Sokcho. Using the wave model SWAN (Booij et al., 1999) and the wave ray method (Munk and Arthur, 1952), we will estimate wave data in open sea from the real-time data and predict the travel time of LSW from the measurement site (near Sokcho) to several target points in the east coast of Korea. Second, the numerical-model based method uses three different numerical models; WW3 in deep water, SWAN in shallow water, and CADMAS-SURF for wave run-up (CDIT). The surface winds from the 72 hours prediction system of NCEP (National Centers for Environmental Prediction) GFS (Global Forecast System) will be inputted in finer grids after interpolating these in certain domains of WW3 and SWAN models. The significant wave heights and peak wave directions predicted by the two methods will be compared to the measured data of LSW at several target points near the coasts. Further, the prediction method will be improved using more measurement sites which will be installed in the future. ReferencesBooij, N., Ris, R.C., and Holthuijsen, L.H. (1999). A third-generation wave model for coastal regions 1. Model description and validation. J. of Geophysical Research, 103(C4), 7649-7666.Munk, W.H. and Arthur, R.S. (1952). Gravity Waves. 13. Wave Intensity along a Refracted Ray

  9. Effects of deep brain stimulation of the subthalamic nucleus on perceptual decision making.

    PubMed

    Zaehle, Tino; Wagenbreth, Caroline; Voges, Jürgen; Heinze, Hans-Jochen; Galazky, Imke

    2017-02-20

    When faced with difficult decisions, people prefer to stay with the default. This status quo bias often leads to suboptimal choice behavior. Neurophysiological evidence suggests a pivot role of the Subthalamic Nucleus (STN) for overcoming such status quo bias in difficult decisions, but causal evidence is lacking. The present study investigated whether subthalamic deep brain stimulation (DBS) in patients with Parkinson's disease (PD) influences the status quo bias. Eighteen PD patients treated with STN-DBS performed a difficult perceptual decision task incorporating intrinsic status quo option. Patients were tested with (ON) and without (OFF) active STN stimulation. Our results show that DBS of the STN affected perceptual decision making in PD patients depending on the difficulty of decision. STN-DBS improved difficult perceptual decisions due to a selective increase in accuracy (hit rate) that was independent of response bias (no effect on false alarm rate). Furthermore, STN-DBS impacted status quo bias as a function of baseline impulsivity. In impulsive patients, STN-DBS increased the default bias, whereas in less impulsive PD patients, DBS of the STN reduced the status quo bias. In line with our hypothesis, STN-DBS selectively affected the tendency to stick with the default option on difficult decisions, and promoted increased decision accuracy. Moreover, we demonstrate the impact of baseline cognitive abilities on DBS-related performance changes in PD patients. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

  10. Effects of subthalamic nucleus stimulation on motor cortex plasticity in Parkinson disease

    PubMed Central

    Kim, Sang Jin; Udupa, Kaviraja; Ni, Zhen; Moro, Elena; Gunraj, Carolyn; Mazzella, Filomena; Lozano, Andres M.; Hodaie, Mojgan; Lang, Anthony E.

    2015-01-01

    Objective: We hypothesized that subthalamic nucleus (STN) deep brain stimulation (DBS) will improve long-term potentiation (LTP)-like plasticity in motor cortex in Parkinson disease (PD). Methods: We studied 8 patients with PD treated with STN-DBS and 9 age-matched healthy controls. Patients with PD were studied in 4 sessions in medication (Med) OFF/stimulator (Stim) OFF, Med-OFF/Stim-ON, Med-ON/Stim-OFF, and Med-ON/Stim-ON states in random order. Motor evoked potential amplitude and cortical silent period duration were measured at baseline before paired associated stimulation (PAS) and at 3 different time intervals (T0, T30, T60) up to 60 minutes after PAS in the abductor pollicis brevis and abductor digiti minimi muscles. Results: Motor evoked potential size significantly increased after PAS in controls (+67.7% of baseline at T30) and in patients in the Med-ON/Stim-ON condition (+55.8% of baseline at T30), but not in patients in the Med-OFF/Stim-OFF (−0.4% of baseline at T30), Med-OFF/Stim-ON (+10.3% of baseline at T30), and Med-ON/Stim-OFF conditions (+17.3% of baseline at T30). Cortical silent period duration increased after PAS in controls but not in patients in all test conditions. Conclusions: Our findings suggest that STN-DBS together with dopaminergic medications restore LTP-like plasticity in motor cortex in PD. Restoration of cortical plasticity may be one of the mechanisms of how STN-DBS produces clinical benefit. PMID:26156511

  11. Apathy following Bilateral Deep Brain Stimulation of Subthalamic Nucleus in Parkinson's Disease: A Meta-Analysis

    PubMed Central

    Zhang, Xiaona

    2018-01-01

    Bilateral deep brain stimulation of subthalamic nucleus (STN-DBS) has proven effective in improving motor symptoms in Parkinson's disease (PD) patients. However, psychiatric changes after surgery are controversial. In this study, we specifically analyzed apathy following bilateral STN-DBS in PD patients using a meta-analysis. Relevant articles utilized for this study were obtained through literature search on PubMed, ScienceDirect, and Embase databases. The articles included were those contained both pre- and postsurgery apathy data acquired using the Starkstein Apathy Scale or Apathy Evaluation Scale with patient follow-up of at least three months. A total of 9 out of 86 articles were included in our study through this strict screening process. Standardized mean difference (SMD), that is, Cohen's d, with a 95% confidence interval (CI) was calculated to show the change. We found a significant difference between the presurgery stage and the postsurgery stage scores (SMD = 0.35, 95% CI: 0.17∼0.52, P < 0.001). STN-DBS seems to relatively worsen the condition of apathy, which may result from both the surgery target (subthalamic nucleus) and the reduction of dopaminergic medication. Further studies should focus on the exact mechanisms of possible postoperative apathy in the future.

  12. Single actuator wave-like robot (SAW): design, modeling, and experiments.

    PubMed

    Zarrouk, David; Mann, Moshe; Degani, Nir; Yehuda, Tal; Jarbi, Nissan; Hess, Amotz

    2016-07-01

    In this paper, we present a single actuator wave-like robot, a novel bioinspired robot which can move forward or backward by producing a continuously advancing wave. The robot has a unique minimalistic mechanical design and produces an advancing sine wave, with a large amplitude, using only a single motor but with no internal straight spine. Over horizontal surfaces, the robot does not slide relative to the surface and its direction of locomotion is determined by the direction of rotation of the motor. We developed a kinematic model of the robot that accounts for the two-dimensional mechanics of motion and yields the speed of the links relative to the motor. Based on the optimization of the kinematic model, and accounting for the mechanical constraints, we have designed and built multiple versions of the robot with different sizes and experimentally tested them (see movie). The experimental results were within a few percentages of the expectations. The larger version attained a top speed of 57 cm s(-1) over a horizontal surface and is capable of climbing vertically when placed between two walls. By optimizing the parameters, we succeeded in making the robot travel by 13% faster than its own wave speed.

  13. Control of the subthalamic innervation of substantia nigra pars reticulata by D1 and D2 dopamine receptors.

    PubMed

    Ibañez-Sandoval, Osvaldo; Hernández, Adán; Florán, Benjamin; Galarraga, Elvira; Tapia, Dagoberto; Valdiosera, Rene; Erlij, David; Aceves, Jorge; Bargas, José

    2006-03-01

    The effects of activating dopaminergic D1 and D2 class receptors of the subthalamic projections that innervate the pars reticulata of the subtantia nigra (SNr) were explored in slices of the rat brain using the whole cell patch-clamp technique. Excitatory postsynaptic currents (EPSCs) that could be blocked by 6-cyano-7-nitroquinoxalene-2,3-dione and D-(-)-2-amino-5-phosphonopentanoic acid were evoked onto reticulata GABAergic projection neurons by local field stimulation inside the subthalamic nucleus in the presence of bicuculline. Bath application of (RS)-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride (SKF-38393), a dopaminergic D1-class receptor agonist, increased evoked EPSCs by approximately 30% whereas the D2-class receptor agonist, trans-(-)-4aR-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrazolo(3,4-g)quinoline (quinpirole), reduced EPSCs by approximately 25%. These apparently opposing actions were blocked by the specific D1- and D2-class receptor antagonists: R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H-3-benzazepinehydrochloride (SCH 23390) and S-(-)-5-amino-sulfonyl-N-[(1-ethyl-2-pyrrolidinyl)-methyl]-2-methoxybenzamide (sulpiride), respectively. Both effects were accompanied by changes in the paired-pulse ratio, indicative of a presynaptic site of action. The presynaptic location of dopamine receptors at the subthalamonigral projections was confirmed by mean-variance analysis. The effects of both SKF-38393 and quinpirole could be observed on terminals contacting the same postsynaptic neuron. Sulpiride and SCH 23390 enhanced and reduced the evoked EPSC, respectively, suggesting a constitutive receptor activation probably arising from endogenous dopamine. These data suggest that dopamine presynaptically modulates the subthalamic projection that targets GABAergic neurons of the SNr. Implications of this modulation for basal ganglia function are discussed.

  14. [Effects of simultaneous transplant of foetal mesencephalic cells in the striatum and the subthalamic nucleus of hemiparkinsonian rats].

    PubMed

    Pavón-Fuentes, N; Macías-González, R; Blanco-Lezcano, L; Alvarez-González, L; Martínez-Martí, L; Castillo-Díaz, L; De La Cuétara Bernal, K; Díaz, C; Lorigados-Pedre, L; Coro, Y; García-Varona, A Y; Rosillo, J C; Díaz, E

    The main strategy followed in neural transplants as a method of treatment for Parkinson s disease, both experimental and clinical, has been to introduce foetal mesencephalic cells into the target area: the striatum. However, when the dopaminergic cells in the substantia nigra degenerate, not only is the dopaminergic innervation of the striatum affected but also other nuclei: globus pallidus, substantia nigra, substantia nigra pars reticulata and subthalamic nucleus. A series of data from pharmacological and physiological studies offer strong evidence that the dopamine released in these nuclei may play an important role in regulating the output nuclei of the basal ganglia. To evaluate the effect of transplanting foetal mesencephalic cells on the behaviour of 6 OH DA rats when introduced into the striatum and the subthalamic nucleus. 6 OH DA was used to induce lesions in the substantia nigra of rats, which were divided into several experimental groups. The rotating activity induced by D amphetamine (5 mg/kg, intraperitoneally) and apomorphine (0.05 mg/kg, subcutaneously) was evaluated before and three months after the transplant in all the experimental groups, except in the control group of healthy rats. The hemiparkinsonian rats received a total of 350,000 foetal ventral mesencephalic cells, which were implanted within small deposits in the striatum (8) and in the subthalamic nucleus (4). Rotation induced by both drugs was significantly lower (p= 0.05) in animals that had had dopaminergic cells transplanted into the striatum body. No significant improvement in this behaviour was to be found when transplants were limited to just the subthalamus or, simultaneously, also to the striatum. A significant increase in rotating behaviour induced by apomorphine was observed in the group which received a transplant in just the subthalamus.

  15. Negative refraction of acoustic waves using a foam-like metallic structure

    NASA Astrophysics Data System (ADS)

    Hladky-Hennion, A.-C.; Vasseur, J. O.; Haw, G.; Croënne, C.; Haumesser, L.; Norris, A. N.

    2013-04-01

    A phononic crystal (PC) slab made of a single metallic phase is shown, theoretically and experimentally, to display perfect negative index matching and focusing capability when surrounded with water. The proposed PC slab is a centimeter scale hollow metallic foam-like structure in which acoustic energy is mediated via the metal lattice. The negative index property arises from an isolated branch of the dispersion curves corresponding to a mode that can be coupled to incident acoustic waves in surrounding water. This band also intercepts the water sound line at a frequency in the ultrasonic range. The metallic structure is consequently a candidate for the negative refraction of incident longitudinal waves.

  16. Comparing Realistic Subthalamic Nucleus Neuron Models

    NASA Astrophysics Data System (ADS)

    Njap, Felix; Claussen, Jens C.; Moser, Andreas; Hofmann, Ulrich G.

    2011-06-01

    The mechanism of action of clinically effective electrical high frequency stimulation is still under debate. However, recent evidence points at the specific activation of GABA-ergic ion channels. Using a computational approach, we analyze temporal properties of the spike trains emitted by biologically realistic neurons of the subthalamic nucleus (STN) as a function of GABA-ergic synaptic input conductances. Our contribution is based on a model proposed by Rubin and Terman and exhibits a wide variety of different firing patterns, silent, low spiking, moderate spiking and intense spiking activity. We observed that most of the cells in our network turn to silent mode when we increase the GABAA input conductance above the threshold of 3.75 mS/cm2. On the other hand, insignificant changes in firing activity are observed when the input conductance is low or close to zero. We thus reproduce Rubin's model with vanishing synaptic conductances. To quantitatively compare spike trains from the original model with the modified model at different conductance levels, we apply four different (dis)similarity measures between them. We observe that Mahalanobis distance, Victor-Purpura metric, and Interspike Interval distribution are sensitive to different firing regimes, whereas Mutual Information seems undiscriminative for these functional changes.

  17. Role of dysphagia in evaluating Parkinson patients for subthalamic nucleus stimulation: a case report.

    PubMed

    Allert, Niels; Kelm, Daniela; Spottke, Annika; Coenen, Volker A

    2011-09-01

    In the selection of Parkinson patients for deep brain stimulation (DBS) of the subthalamic nucleus (STN) a risk-benefit-analysis is performed regarding symptoms that commonly improve and symptoms that may deteriorate. Speech is among the symptoms that may deteriorate. In contrast, the differential effects of STN-DBS on swallowing are less clear. Here, we present a Parkinson patient with dysphagia from concomitant oculo-pharyngeal muscle dystrophy successfully treated by STN-DBS. The role of dysphagia in evaluating Parkinson patients for STN-DBS is discussed.

  18. Subthalamic stimulation improves the cerebral hemodynamic response to the cold pressure test in patients with Parkinson's disease.

    PubMed

    Rätsep, Tõnu; Asser, Toomas

    2012-01-01

    Disturbances of the autonomic nervous system are common in patients with Parkinson's disease (PD) but the effect of deep brain stimulation of the subthalamic nucleus on cerebrovascular reactivity is not entirely known. Seven patients in an advanced stage of the disease and seven healthy age-matched controls participated in the study, which took place after one night of drug withdrawal. Cerebral blood flow velocity was continuously monitored on both sides with transcranial Doppler ultrasound, and cerebrovascular reactivity (CR) was evaluated with the cold pressure test. The measurements were repeated and compared during the stimulation-on and -off phases. The PD patients had significantly higher CR values in the stimulation-on than -off conditions (15.1% ± 6.9 versus 9.4% ± 6.2; p = 0.03). CR values were higher in controls than in patients in the stimulation-off condition (20.4% ± 12.5 versus 9.4% ± 6.2; p = 0.007) without a significant difference with the stimulation-on phase. CR, evaluated by the response to the cold pressure test, is impaired in patients with advanced PD and improved by subthalamic nucleus. Copyright © 2012 Wiley Periodicals, Inc.

  19. Activity Parameters of Subthalamic Nucleus Neurons Selectively Predict Motor Symptom Severity in Parkinson's Disease

    PubMed Central

    Gulberti, Alessandro; Zittel, Simone; Tudor Jones, Adam A.; Fickel, Ulrich; Münchau, Alexander; Köppen, Johannes A.; Gerloff, Christian; Westphal, Manfred; Buhmann, Carsten; Hamel, Wolfgang; Engel, Andreas K.

    2014-01-01

    Parkinson's disease (PD) is a heterogeneous disorder that leads to variable expression of several different motor symptoms. While changes in firing rate, pattern, and oscillation of basal ganglia neurons have been observed in PD patients and experimental animals, there is limited evidence linking them to specific motor symptoms. Here we examined this relationship using extracellular recordings of subthalamic nucleus neurons from 19 PD patients undergoing surgery for deep brain stimulation. For each patient, ≥10 single units and/or multi-units were recorded in the OFF medication state. We correlated the proportion of neurons displaying different activities with preoperative Unified Parkinson's Disease Rating Scale subscores (OFF medication). The mean spectral power at sub-beta frequencies and percentage of units oscillating at beta frequencies were positively correlated with the axial and limb rigidity scores, respectively. The percentage of units oscillating at gamma frequency was negatively correlated with the bradykinesia scores. The mean intraburst rate was positively correlated with both bradykinesia and axial scores, while the related ratio of interspike intervals below/above 10 ms was positively correlated with these symptoms and limb rigidity. None of the activity parameters correlated with tremor. The grand average of all the significantly correlated subthalamic nucleus activities accounted for >60% of the variance of the combined bradykinetic-rigid and axial scores. Our results demonstrate that the occurrence of alterations in the rate and pattern of basal ganglia neurons could partly underlie the variability in parkinsonian phenotype. PMID:24790198

  20. To move or not to move: subthalamic deep brain stimulation effects on implicit motor simulation.

    PubMed

    Tomasino, Barbara; Marin, Dario; Eleopra, Roberto; Rinaldo, Sara; Cristian, Lettieri; Marco, Mucchiut; Enrico, Belgrado; Zanier, Monica; Budai, Riccardo; Mondani, Massimo; D'Auria, Stanislao; Skrap, Miran; Fabbro, Franco

    2014-07-29

    We explored implicit motor simulation processes in Parkinson's Disease (PD) patients with ON-OFF subthalamic deep brain stimulation (DBS) of the sub-thalamic nucleus (STN). Participants made lexical decisions about hand action-related verbs, abstract verbs, and pseudowords presented either within a positive (e.g., "Do …") or a negative (e.g., "Don't …") sentence context. Healthy controls showed significantly slower responses for hand-action verbs (vs. abstract verbs) in the negative (vs. positive) context, which suggests that negative contexts may suppress motor simulation or preparation processes. The STN-DBS improves cortical motor functions, thus patients are expected to perform at the same level as unimpaired subjects in the ON condition. By contrast, the 50% reduced DBS is expected to result in a reduced activation for motor information, which in turn might cause a reduced, if not absent, context modulation. PD patients exhibited the same pattern as controls when their DBS was at 100% ON; however, reducing the DBS to 50% had a deleterious outcome on the positive faster than negative context effect, suggesting that the altered inhibition mechanism in PD could be responsible for the missed effect. In addition, our results confirm the view that implicit motor simulation mechanisms behind action-related verb processing are flexible and context-dependent. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Destructive tsunami-like wave generated by surf beat over a coral reef during Typhoon Haiyan.

    PubMed

    Roeber, Volker; Bricker, Jeremy D

    2015-08-06

    Storm surges cause coastal inundation due to setup of the water surface resulting from atmospheric pressure, surface winds and breaking waves. Here we show that during Typhoon Haiyan, the setup generated by breaking waves near the fringing-reef-protected town of Hernani, the Philippines, oscillated with the incidence of large and small wave groups, and steepened into a tsunami-like wave that caused extensive damage and casualties. Though fringing reefs usually protect coastal communities from moderate storms, they can exacerbate flooding during strong events with energetic waves. Typical for reef-type bathymetries, a very short wave-breaking zone over the steep reef face facilitates the freeing of infragravity-period fluctuations (surf beat) with little energy loss. Since coastal flood planning relies on phase-averaged wave modelling, infragravity surges are not being accounted for. This highlights the necessity for a policy change and the adoption of phase-resolving wave models for hazard assessment in regions with fringing reefs.

  2. Destructive tsunami-like wave generated by surf beat over a coral reef during Typhoon Haiyan

    PubMed Central

    Roeber, Volker; Bricker, Jeremy D.

    2015-01-01

    Storm surges cause coastal inundation due to setup of the water surface resulting from atmospheric pressure, surface winds and breaking waves. Here we show that during Typhoon Haiyan, the setup generated by breaking waves near the fringing-reef-protected town of Hernani, the Philippines, oscillated with the incidence of large and small wave groups, and steepened into a tsunami-like wave that caused extensive damage and casualties. Though fringing reefs usually protect coastal communities from moderate storms, they can exacerbate flooding during strong events with energetic waves. Typical for reef-type bathymetries, a very short wave-breaking zone over the steep reef face facilitates the freeing of infragravity-period fluctuations (surf beat) with little energy loss. Since coastal flood planning relies on phase-averaged wave modelling, infragravity surges are not being accounted for. This highlights the necessity for a policy change and the adoption of phase-resolving wave models for hazard assessment in regions with fringing reefs. PMID:26245839

  3. The thermal-wave model: A Schroedinger-like equation for charged particle beam dynamics

    NASA Technical Reports Server (NTRS)

    Fedele, Renato; Miele, G.

    1994-01-01

    We review some results on longitudinal beam dynamics obtained in the framework of the Thermal Wave Model (TWM). In this model, which has recently shown the capability to describe both longitudinal and transverse dynamics of charged particle beams, the beam dynamics is ruled by Schroedinger-like equations for the beam wave functions, whose squared modulus is proportional to the beam density profile. Remarkably, the role of the Planck constant is played by a diffractive constant epsilon, the emittance, which has a thermal nature.

  4. Pitch Variability in Patients with Parkinson's Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus

    ERIC Educational Resources Information Center

    Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; van Doorn, Jan

    2013-01-01

    Purpose: The purpose of the present study was to examine the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) pitch characteristics of connected speech in patients with Parkinson's disease (PD). Method: The authors evaluated 16 patients preoperatively and 12 months after DBS surgery. Eight…

  5. Generation and evolution of mode-locked noise-like square-wave pulses in a large-anomalous-dispersion Er-doped ring fiber laser.

    PubMed

    Liu, Jun; Chen, Yu; Tang, Pinghua; Xu, Changwen; Zhao, Chujun; Zhang, Han; Wen, Shuangchun

    2015-03-09

    In a passively mode-locked Erbium-doped fiber laser with large anomalous-dispersion, we experimentally demonstrate the formation of noise-like square-wave pulse, which shows quite different features from conventional dissipative soliton resonance (DSR). The corresponding temporal and spectral characteristics of a variety of operation states, including Q-switched mode-locking, continuous-wave mode-locking and Raman-induced noise-like pulse near the lasing threshold, are also investigated. Stable noise-like square-wave mode-locked pulses can be obtained at a fundamental repetition frequency of 195 kHz, with pulse packet duration tunable from 15 ns to 306 ns and per-pulse energy up to 200 nJ. By reducing the linear cavity loss, stable higher-order harmonic mode-locking had also been observed, with pulse duration ranging from 37 ns at the 21st order harmonic wave to 320 ns at the fundamental order. After propagating along a piece of long telecom fiber, the generated square-wave pulses do not show any obvious change, indicating that the generated noise-like square-wave pulse can be considered as high-energy pulse packet for some promising applications. These experimental results should shed some light on the further understanding of the mechanism and characteristics of noise-like square-wave pulses.

  6. The Subthalamic Nucleus, Limbic Function, and Impulse Control.

    PubMed

    Rossi, P Justin; Gunduz, Aysegul; Okun, Michael S

    2015-12-01

    It has been well documented that deep brain stimulation (DBS) of the subthalamic nucleus (STN) to address some of the disabling motor symptoms of Parkinson's disease (PD) can evoke unintended effects, especially on non-motor behavior. This observation has catalyzed more than a decade of research concentrated on establishing trends and identifying potential mechanisms for these non-motor effects. While many issues remain unresolved, the collective result of many research studies and clinical observations has been a general recognition of the role of the STN in mediating limbic function. In particular, the STN has been implicated in impulse control and the related construct of valence processing. A better understanding of STN involvement in these phenomena could have important implications for treating impulse control disorders (ICDs). ICDs affect up to 40% of PD patients on dopamine agonist therapy and approximately 15% of PD patients overall. ICDs have been reported to be associated with STN DBS. In this paper we will focus on impulse control and review pre-clinical, clinical, behavioral, imaging, and electrophysiological studies pertaining to the limbic function of the STN.

  7. [Single and Network Neuron Activity of Subthalamic Nucleus at Impulsive and Delayed (Self-Control) Reactions in Choice Behavior].

    PubMed

    Sidorina, V V; Gerasimova, Yu A; Kuleshova, E P; Merzhanova, G Kh

    2015-01-01

    During our experiments on cats was investigated the subthalamic neuron activity at different types of behavior in case of reinforcement choice depending on its value and availability. In chronic experiences the multiunit activity in subthalamic nucleus (STN) and orbitofrontal cortex (FC) has been recorded. Multiunit activity was analyzed over frequency and network properties of spikes. It was shown, that STN neurons reaction to different reinforcements and conditional stimulus at short- or long-delay reactions was represented by increasing or decreasing of frequency of single neurons. However the same STN neu- rons responded with increasing of frequency of single neuron during expectation of mix-bread-meat and decreasing--during the meat expectation. It has been revealed, that the number of STN interneuron interactions was authentic more at impulsive behavior than at self-control choice of behavior. The number of interactions between FC and STN neurons within intervals of 0-30 Ms was authentic more at display impulsive than during self-control behavior. These results suppose that FC and STN neurons participate in integration of reinforcement estimation; and distinctions in a choice of behavior are defined by the local and distributed interneuron interactions of STN and FC.

  8. Classical Wave Model of Quantum-Like Processing in Brain

    NASA Astrophysics Data System (ADS)

    Khrennikov, A.

    2011-01-01

    We discuss the conjecture on quantum-like (QL) processing of information in the brain. It is not based on the physical quantum brain (e.g., Penrose) - quantum physical carriers of information. In our approach the brain created the QL representation (QLR) of information in Hilbert space. It uses quantum information rules in decision making. The existence of such QLR was (at least preliminary) confirmed by experimental data from cognitive psychology. The violation of the law of total probability in these experiments is an important sign of nonclassicality of data. In so called "constructive wave function approach" such data can be represented by complex amplitudes. We presented 1,2 the QL model of decision making. In this paper we speculate on a possible physical realization of QLR in the brain: a classical wave model producing QLR . It is based on variety of time scales in the brain. Each pair of scales (fine - the background fluctuations of electromagnetic field and rough - the cognitive image scale) induces the QL representation. The background field plays the crucial role in creation of "superstrong QL correlations" in the brain.

  9. The subthalamic nucleus during decision-making with multiple alternatives.

    PubMed

    Keuken, Max C; Van Maanen, Leendert; Bogacz, Rafal; Schäfer, Andreas; Neumann, Jane; Turner, Robert; Forstmann, Birte U

    2015-10-01

    Several prominent neurocomputational models predict that an increase of choice alternatives is modulated by increased activity in the subthalamic nucleus (STN). In turn, increased STN activity allows prolonged accumulation of information. At the same time, areas in the medial frontal cortex such as the anterior cingulate cortex (ACC) and the pre-SMA are hypothesized to influence the information processing in the STN. This study set out to test concrete predictions of STN activity in multiple-alternative decision-making using a multimodal combination of 7 Tesla structural and functional Magnetic Resonance Imaging, and ancestral graph (AG) modeling. The results are in line with the predictions in that increased STN activity was found with an increasing amount of choice alternatives. In addition, our study shows that activity in the ACC is correlated with activity in the STN without directly modulating it. This result sheds new light on the information processing streams between medial frontal cortex and the basal ganglia. © 2015 Wiley Periodicals, Inc.

  10. Deep Brain Stimulation of the Subthalamic Nucleus Parameter Optimization for Vowel Acoustics and Speech Intelligibility in Parkinson's Disease

    ERIC Educational Resources Information Center

    Knowles, Thea; Adams, Scott; Abeyesekera, Anita; Mancinelli, Cynthia; Gilmore, Greydon; Jog, Mandar

    2018-01-01

    Purpose: The settings of 3 electrical stimulation parameters were adjusted in 12 speakers with Parkinson's disease (PD) with deep brain stimulation of the subthalamic nucleus (STN-DBS) to examine their effects on vowel acoustics and speech intelligibility. Method: Participants were tested under permutations of low, mid, and high STN-DBS frequency,…

  11. Phenytoin-induced severe gingival overgrowth in a child

    PubMed Central

    Kumar, Rakesh; Singh, Rajeev Kumar; Verma, Nidhi; Verma, Umesh Pratap

    2014-01-01

    Gingival enlargement or overgrowth (GO) is a common complication of the anticonvulsant drug phenytoin (PHT). GO is evident in almost half of the patients receiving PHT therapy. PHT-induced gingival overgrowth (PGO) is more common in children than in adults and affects both males and females equally. PGO may vary from mild to severe and does not seem to be dose dependant. It is supposed that PHT and its metabolites cause a direct effect on the periodontal tissues; however, poor oral hygiene may contribute to the severity of gingival inflammation in patients with PGO. Management of PGO includes meticulous oral hygiene practice to reduce inflammation and surgical excision of the overgrown tissue, known as gingivectomy. We present a case of PHT-induced severe GO in a 10-year-old boy and discuss the clinical features, aetiology, pathogenesis and management of PGO. PMID:25053668

  12. Aptamer cell sensor based on porous graphene oxide decorated ion-selective-electrode: Double sensing platform for cell and ion.

    PubMed

    Zhang, Rong; Gu, Yajun; Wang, Zhongrong; Li, Yueguo; Fan, Qingjie; Jia, Yunfang

    2018-06-15

    Enlightened by the emerging cell-ion detection based on ion-selective-electrode (ISE), an aptamer capturing and ISE transducing (AC&IT) strategy is proposed on the porous graphene oxide (PGO) decorated ISE (PGO-ISE), its performances in both cell and ion detections are examined by use of AS1411 targeted A549 cell detection and iodide-ISE as proof-of-concept. Firstly, GO flakes, exfoliated from graphite by modified Hummers method, are cross-linked by thiourea mediated hydrothermal process, to 3-dimension networked PGO which is identified by scanning-electron-microscope, UV-visible absorbance and X-ray photoelectron spectroscopy; its enhancing effect for cell capturing is evaluated by microscopy. Then, PGO-ISE is constructed by drop-coating PGO film on the surface of ISE and followed by covalently anchoring AS1411. Electrochemistry measurements for different state ISE (blank, PGO coated, AS1411 anchored and A549 captured) are performed by our home-made ISE-measuring system. It is demonstrated that the best cell-sensitivity in buffer is - 25.21 mV/log 10 C A549 (R 2 = 0.91), resolution in blood is 10 cells/ml. Interestingly, due to PGO's scaffold protection to the ionophore, I - -sensitivity is preserved as - 42.98 mV/pI (R 2 = 0.95, pI = -log 10 (C I )). Theoretical explanations are provided for the double-sensing phenomenon according to basic ISE principle. It is believed the PGO-ISE based aptamer cell sensor will be a promising experimental means for biomedical researches. Copyright © 2018. Published by Elsevier B.V.

  13. Auditory Inhibition of Rapid Eye Movements and Dream Recall from REM Sleep

    PubMed Central

    Stuart, Katrina; Conduit, Russell

    2009-01-01

    Study Objectives: There is debate in dream research as to whether ponto-geniculo-occipital (PGO) waves or cortical arousal during sleep underlie the biological mechanisms of dreaming. This study comprised 2 experiments. As eye movements (EMs) are currently considered the best noninvasive indicator of PGO burst activity in humans, the aim of the first experiment was to investigate the effect of low-intensity repeated auditory stimulation on EMs (and inferred PGO burst activity) during REM sleep. It was predicted that such auditory stimuli during REM sleep would have a suppressive effect on EMs. The aim of the second experiment was to examine the effects of this auditory stimulation on subsequent dream reporting on awakening. Design: Repeated measures design with counterbalanced order of experimental and control conditions across participants. Setting: Sleep laboratory based polysomnography (PSG) Participants: Experiment 1: 5 males and 10 females aged 18-35 years (M = 20.8, SD = 5.4). Experiment 2: 7 males and 13 females aged 18-35 years (M = 23.3, SD = 5.5). Interventions: Below-waking threshold tone presentations during REM sleep compared to control REM sleep conditions without tone presentations. Measurements and Results: PSG records were manually scored for sleep stages, EEG arousals, and EMs. Auditory stimulation during REM sleep was related to: (a) an increase in EEG arousal, (b) a decrease in the amplitude and frequency of EMs, and (c) a decrease in the frequency of visual imagery reports on awakening. Conclusions: The results of this study provide phenomenological support for PGO-based theories of dream reporting on awakening from sleep in humans. Citation: Stuart K; Conduit R. Auditory inhibition of rapid eye movements and dream recall from REM sleep. SLEEP 2009;32(3):399–408. PMID:19294960

  14. Shock-wave-like structures induced by an exothermic neutralization reaction in miscible fluids

    NASA Astrophysics Data System (ADS)

    Bratsun, Dmitry; Mizev, Alexey; Mosheva, Elena; Kostarev, Konstantin

    2017-11-01

    We report shock-wave-like structures that are strikingly different from previously observed fingering instabilities, which occur in a two-layer system of miscible fluids reacting by a second-order reaction A +B →S in a vertical Hele-Shaw cell. While the traditional analysis expects the occurrence of a diffusion-controlled convection, we show both experimentally and theoretically that the exothermic neutralization reaction can also trigger a wave with a perfectly planar front and nearly discontinuous change in density across the front. This wave propagates fast compared with the characteristic diffusion times and separates the motionless fluid and the area with anomalously intense convective mixing. We explain its mechanism and introduce a new dimensionless parameter, which allows to predict the appearance of such a pattern in other systems. Moreover, we show that our governing equations, taken in the inviscid limit, are formally analogous to well-known shallow-water equations and adiabatic gas flow equations. Based on this analogy, we define the critical velocity for the onset of the shock wave which is found to be in the perfect agreement with the experiments.

  15. Lidar observations of wave-like structure in the atmospheric sodium layer

    NASA Technical Reports Server (NTRS)

    Rowlett, J. R.; Gardner, C. S.; Richter, E. S.; Sechrist, C. F., Jr.

    1978-01-01

    The University of Illinois (Urbana) lidar system has been developed to study the atmospheric sodium layer near 90 km altitude through the mechanism of resonance scattering. The photocount data are processed using digital smoothing filters to obtain continuous estimates of the sodium density versus altitude. The filter cutoff frequency is related to the height resolution and accuracy of the estimated profile. Lidar photocount data processed using this filtering technique show wave-like structures in the sodium layer which move downward with time. The waves have typical wavelengths of 3-15 km and phase velocities of less than 1 m/sec. The movement of these structures seems to be independent of the motion of the bottomside of the layer, which also has been observed to move up or down by as much as 2 km over a period of a few hours.

  16. Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model

    PubMed Central

    Zheng, Deyu; Jiang, Xiaohua; Zhao, Junpeng; Duan, Deyi; Zhao, Huanying; Xu, Qunyuan

    2013-01-01

    The aim of the present study is to detect a combination method to utilize gene therapy for the treatment of Parkinson’s disease (PD). Here, a PD rat model is used for the in vivo gene therapy of a recombinant adeno-associated virus (AAV2) containing a human glutamic acid decarboxylase 65 (rAAV2-hGAD65) gene delivered to the subthalamic nucleus (STN). This is combined with the ex vivo gene delivery of tyrosine hydroxylase (TH) by fibroblasts injected into the striatum. After the treatment, the rotation behavior was improved with the greatest efficacy in the combination group. The results of immunohistochemistry showed that hGAD65 gene delivery by AAV2 successfully led to phenotypic changes of neurons in STN. And the levels of glutamic acid and GABA in the internal segment of the globus pallidus (GPi) and substantia nigra pars reticulata (SNr) were obviously lower than the control groups. However, hGAD65 gene transfer did not effectively protect surviving dopaminergic neurons in the SNc and VTA. This study suggests that subthalamic hGAD65 gene therapy and combined with TH gene therapy can alleviate symptoms of the PD model rats, independent of the protection the DA neurons from death. PMID:23738148

  17. Causal role for the subthalamic nucleus in interrupting behavior

    PubMed Central

    Fife, Kathryn H; Gutierrez-Reed, Navarre A; Zell, Vivien; Bailly, Julie; Lewis, Christina M; Aron, Adam R; Hnasko, Thomas S

    2017-01-01

    Stopping or pausing in response to threats, conflicting information, or surprise is fundamental to behavior. Evidence across species has shown that the subthalamic nucleus (STN) is activated by scenarios involving stopping or pausing, yet evidence that the STN causally implements stops or pauses is lacking. Here we used optogenetics to activate or inhibit mouse STN to test its putative causal role. We first demonstrated that optogenetic stimulation of the STN excited its major projection targets. Next we showed that brief activation of STN projection neurons was sufficient to interrupt or pause a self-initiated bout of licking. Finally, we developed an assay in which surprise was used to interrupt licking, and showed that STN inhibition reduced the disruptive effect of surprise. Thus STN activation interrupts behavior, and blocking the STN blunts the interruptive effect of surprise. These results provide strong evidence that the STN is both necessary and sufficient for such forms of behavioral response suppression. DOI: http://dx.doi.org/10.7554/eLife.27689.001 PMID:28742497

  18. Realization of localized Bohr-like wave packets.

    PubMed

    Mestayer, J J; Wyker, B; Lancaster, J C; Dunning, F B; Reinhold, C O; Yoshida, S; Burgdörfer, J

    2008-06-20

    We demonstrate a protocol to create localized wave packets in very-high-n Rydberg states which travel in nearly circular orbits around the nucleus. Although these wave packets slowly dephase and eventually lose their localization, their motion can be monitored over several orbital periods. These wave packets represent the closest analog yet achieved to the original Bohr model of the hydrogen atom, i.e., an electron in a circular classical orbit around the nucleus. The possible extension of the approach to create "planetary atoms" in highly correlated stable multiply excited states is discussed.

  19. Current steering to activate targeted neural pathways during deep brain stimulation of the subthalamic region

    PubMed Central

    Chaturvedi, Ashutosh; Foutz, Thomas J.; McIntyre, Cameron C.

    2012-01-01

    Deep brain stimulation (DBS) has steadily evolved into an established surgical therapy for numerous neurological disorders, most notably Parkinson’s disease (PD). Traditional DBS technology relies on voltage-controlled stimulation with a single source; however, recent engineering advances are providing current-controlled devices with multiple independent sources. These new stimulators deliver constant current to the brain tissue, irrespective of impedance changes that occur around the electrode, and enable more specific steering of current towards targeted regions of interest. In this study, we examined the impact of current steering between multiple electrode contacts to directly activate three distinct neural populations in the subthalamic region commonly stimulated for the treatment of PD: projection neurons of the subthalamic nucleus (STN), globus pallidus internus (GPi) fibers of the lenticular fasiculus, and internal capsule (IC) fibers of passage. We used three-dimensional finite element electric field models, along with detailed multi-compartment cable models of the three neural populations to determine their activations using a wide range of stimulation parameter settings. Our results indicate that selective activation of neural populations largely depends on the location of the active electrode(s). Greater activation of the GPi and STN populations (without activating any side-effect related IC fibers) was achieved by current steering with multiple independent sources, compared to a single current source. Despite this potential advantage, it remains to be seen if these theoretical predictions result in a measurable clinical effect that outweighs the added complexity of the expanded stimulation parameter search space generated by the more flexible technology. PMID:22277548

  20. Fast and controlled fabrication of porous graphene oxide: application of AFM tapping for mechano-chemistry

    NASA Astrophysics Data System (ADS)

    Chu, Liangyong; Korobko, Alexander V.; Bus, Marcel; Boshuizen, Bart; Sudhölter, Ernst J. R.; Besseling, Nicolaas A. M.

    2018-05-01

    This paper describes a novel method to fabricate porous graphene oxide (PGO) from GO by exposure to oxygen plasma. Compared to other methods to fabricate PGO described so far, e.g. the thermal and steam etching methods, oxygen plasma etching method is much faster. We studied the development of the porosity with exposure time using atomic force microscopy (AFM). It was found that the development of PGO upon oxygen-plasma exposure can be controlled by tapping mode AFM scanning using a Si tip. AFM tapping stalls the growth of pores upon further plasma exposure at a level that coincides with the fraction of sp2 carbons in the GO starting material. We suggest that AFM tapping procedure changes the bond structure of the intermediate PGO structure, and these stabilized PGO structures cannot be further etched by oxygen plasma. This constitutes the first report of tapping AFM as a tool for local mechano-chemistry.

  1. Fast and controlled fabrication of porous graphene oxide: application of AFM tapping for mechano-chemistry.

    PubMed

    Chu, Liangyong; Korobko, Alexander V; Bus, Marcel; Boshuizen, Bart; Sudhölter, Ernst J R; Besseling, Nicolaas A M

    2018-05-04

    This paper describes a novel method to fabricate porous graphene oxide (PGO) from GO by exposure to oxygen plasma. Compared to other methods to fabricate PGO described so far, e.g. the thermal and steam etching methods, oxygen plasma etching method is much faster. We studied the development of the porosity with exposure time using atomic force microscopy (AFM). It was found that the development of PGO upon oxygen-plasma exposure can be controlled by tapping mode AFM scanning using a Si tip. AFM tapping stalls the growth of pores upon further plasma exposure at a level that coincides with the fraction of sp 2 carbons in the GO starting material. We suggest that AFM tapping procedure changes the bond structure of the intermediate PGO structure, and these stabilized PGO structures cannot be further etched by oxygen plasma. This constitutes the first report of tapping AFM as a tool for local mechano-chemistry.

  2. Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation on Tongue Movements in Speakers with Parkinson's Disease Using Electropalatography: A Pilot Study

    ERIC Educational Resources Information Center

    Hartinger, Mariam; Tripoliti, Elina; Hardcastle, William J.; Limousin, Patricia

    2011-01-01

    Parkinson's disease (PD) affects speech in the majority of patients. Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in reducing tremor and rigidity. However, its effect on speech is variable. The aim of this pilot study was to quantify the effects of bilateral STN-DBS and medication on articulation, using…

  3. Articulatory Closure Proficiency in Patients with Parkinson's Disease Following Deep Brain Stimulation of the Subthalamic Nucleus and Caudal Zona Incerta

    ERIC Educational Resources Information Center

    Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; Nordh, Erik; van Doorn, Jan

    2014-01-01

    Purpose: The present study aimed at comparing the effects of deep brain stimulation (DBS) treatment of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) on the proficiency in achieving oral closure and release during plosive production of people with Parkinson's disease. Method: Nineteen patients participated preoperatively and…

  4. Diving Response in Rats: Role of the Subthalamic Vasodilator Area

    PubMed Central

    Golanov, Eugene V.; Shiflett, James M.; Britz, Gavin W.

    2016-01-01

    Diving response (DR) is a powerful integrative response targeted toward survival of the hypoxic/anoxic conditions. Being present in all animals and humans, it allows to survive adverse conditions like diving. Earlier, we discovered that forehead stimulation affords neuroprotective effect, decreasing infarction volume triggered by permanent occlusion of the middle cerebral artery in rats. We hypothesized that cold stimulation of the forehead induces DR in rats, which, in turn, exerts neuroprotection. We compared autonomic [AP, heart rate (HR), cerebral blood flow (CBF)] and EEG responses to the known DR-triggering stimulus, ammonia stimulation of the nasal mucosa, cold stimulation of the forehead, and cold stimulation of the glabrous skin of the tail base in anesthetized rats. Responses in AP, HR, CBF, and EEG to cold stimulation of the forehead and ammonia vapors instillation into the nasal cavity were comparable and differed significantly from responses to the cold stimulation of the tail base. Excitotoxic lesion of the subthalamic vasodilator area (SVA), which is known to participate in CBF regulation and to afford neuroprotection upon excitation, failed to affect autonomic components of the DR evoked by forehead cold stimulation or nasal mucosa ammonia stimulation. We conclude that cold stimulation of the forehead triggers physiological response comparable to the response evoked by ammonia vapor instillation into nasal cavity, which is considered as stimulus triggering protective DR. These observations may explain the neuroprotective effect of the forehead stimulation. Data demonstrate that SVA does not directly participate in the autonomic adjustments accompanying DR; however, it is involved in diving-evoked modulation of EEG. We suggest that forehead stimulation can be employed as a stimulus capable of triggering oxygen-conserving DR and can be used for neuroprotective therapy. PMID:27708614

  5. Wave like signatures in aerosol optical depth and associated radiative impacts over the central Himalayan region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shukla, K. K.; Phanikumar, D. V.; Kumar, K.  Niranjan

    2015-10-01

    Doppler Lidar and Multi-Filter Rotating Shadowband Radiometer (MFRSR) observations are utilized to show wave like signatures in aerosol optical depth (AOD) during daytime boundary layer evolution over the Himalayan region. Fourier analysis depicted 60–80 min periods dominant during afternoon hours, implying that observed modulations could be plausible reason for the AOD forenoon–afternoon asymmetry which was previously reported. Inclusion of wave amplitude in diurnal variation of aerosol radiative forcing estimates showed ~40% additional warming in the atmosphere relative to mean AOD. The present observations emphasize the importance of wave induced variations in AOD and radiation budget over the site.

  6. The subthalamic microlesion story in Parkinson's disease: electrode insertion-related motor improvement with relative cortico-subcortical hypoactivation in fMRI.

    PubMed

    Jech, Robert; Mueller, Karsten; Urgošík, Dušan; Sieger, Tomáš; Holiga, Štefan; Růžička, Filip; Dušek, Petr; Havránková, Petra; Vymazal, Josef; Růžička, Evžen

    2012-01-01

    Electrode implantation into the subthalamic nucleus for deep brain stimulation in Parkinson's disease (PD) is associated with a temporary motor improvement occurring prior to neurostimulation. We studied this phenomenon by functional magnetic resonance imaging (fMRI) when considering the Unified Parkinson's Disease Rating Scale (UPDRS-III) and collateral oedema. Twelve patients with PD (age 55.9± (SD)6.8 years, PD duration 9-15 years) underwent bilateral electrode implantation into the subthalamic nucleus. The fMRI was carried out after an overnight withdrawal of levodopa (OFF condition): (i) before and (ii) within three days after surgery in absence of neurostimulation. The motor task involved visually triggered finger tapping. The OFF/UPDRS-III score dropped from 33.8±8.7 before to 23.3±4.8 after the surgery (p<0.001), correlating with the postoperative oedema score (p<0.05). During the motor task, bilateral activation of the thalamus and basal ganglia, motor cortex and insula were preoperatively higher than after surgery (p<0.001). The results became more enhanced after compensation for the oedema and UPDRS-III scores. In addition, the rigidity and axial symptoms score correlated inversely with activation of the putamen and globus pallidus (p<0.0001). One month later, the OFF/UPDRS-III score had returned to the preoperative level (35.8±7.0, p = 0.4).In conclusion, motor improvement induced by insertion of an inactive electrode into the subthalamic nucleus caused an acute microlesion which was at least partially related to the collateral oedema and associated with extensive impact on the motor network. This was postoperatively manifested as lowered movement-related activation at the cortical and subcortical levels and differed from the known effects of neurostimulation or levodopa. The motor system finally adapted to the microlesion within one month as suggested by loss of motor improvement and good efficacy of deep brain stimulation.

  7. The Subthalamic Microlesion Story in Parkinson's Disease: Electrode Insertion-Related Motor Improvement with Relative Cortico-Subcortical Hypoactivation in fMRI

    PubMed Central

    Urgošík, Dušan; Sieger, Tomáš; Holiga, Štefan; Růžička, Filip; Dušek, Petr; Havránková, Petra; Vymazal, Josef; Růžička, Evžen

    2012-01-01

    Electrode implantation into the subthalamic nucleus for deep brain stimulation in Parkinson's disease (PD) is associated with a temporary motor improvement occurring prior to neurostimulation. We studied this phenomenon by functional magnetic resonance imaging (fMRI) when considering the Unified Parkinson's Disease Rating Scale (UPDRS-III) and collateral oedema. Twelve patients with PD (age 55.9± (SD)6.8 years, PD duration 9–15 years) underwent bilateral electrode implantation into the subthalamic nucleus. The fMRI was carried out after an overnight withdrawal of levodopa (OFF condition): (i) before and (ii) within three days after surgery in absence of neurostimulation. The motor task involved visually triggered finger tapping. The OFF/UPDRS-III score dropped from 33.8±8.7 before to 23.3±4.8 after the surgery (p<0.001), correlating with the postoperative oedema score (p<0.05). During the motor task, bilateral activation of the thalamus and basal ganglia, motor cortex and insula were preoperatively higher than after surgery (p<0.001). The results became more enhanced after compensation for the oedema and UPDRS-III scores. In addition, the rigidity and axial symptoms score correlated inversely with activation of the putamen and globus pallidus (p<0.0001). One month later, the OFF/UPDRS-III score had returned to the preoperative level (35.8±7.0, p = 0.4). In conclusion, motor improvement induced by insertion of an inactive electrode into the subthalamic nucleus caused an acute microlesion which was at least partially related to the collateral oedema and associated with extensive impact on the motor network. This was postoperatively manifested as lowered movement-related activation at the cortical and subcortical levels and differed from the known effects of neurostimulation or levodopa. The motor system finally adapted to the microlesion within one month as suggested by loss of motor improvement and good efficacy of deep brain stimulation. PMID:23145068

  8. Pseudobulbar laughter as a levodopa off phenomenon exacerbated by subthalamic deep brain stimulation.

    PubMed

    Chattha, P K; Greene, P E; Ramdhani, Ritesh A

    2015-01-01

    Pseudobulbar affect is a common symptom in neurodegenerative diseases and can also result from lesions in cortical, subcortical and brainstem regions. In Parkinson's disease (PD), pseudobulbar affect (PBA) can occur as a wearing off phenomenon, manifested usually as crying without emotionality. In addition, subthalamic (STN) deep brain stimulation (DBS) has been reported to induce PBA in PD patients with no prior history of such episodes. We present a case of inappropriate laughter lacking mirth as a levodopa OFF phenomenon in a patient with PD, whose laughter also worsened with STN-DBS in his non-medicated state. Levodopa ameliorated his PBA both with and without stimulation. The case demonstrates pseudobulbar laughter as a levodopa OFF phenomenon that is also exacerbated by STN-DBS.

  9. Widespread tsunami-like waves of 23-27 June in the Mediterranean and Black Seas generated by high-altitude atmospheric forcing.

    PubMed

    Šepić, Jadranka; Vilibić, Ivica; Rabinovich, Alexander B; Monserrat, Sebastian

    2015-06-29

    A series of tsunami-like waves of non-seismic origin struck several southern European countries during the period of 23 to 27 June 2014. The event caused considerable damage from Spain to Ukraine. Here, we show that these waves were long-period ocean oscillations known as meteorological tsunamis which are generated by intense small-scale air pressure disturbances. An unique atmospheric synoptic pattern was tracked propagating eastward over the Mediterranean and the Black seas in synchrony with onset times of observed tsunami waves. This pattern favoured generation and propagation of atmospheric gravity waves that induced pronounced tsunami-like waves through the Proudman resonance mechanism. This is the first documented case of a chain of destructive meteorological tsunamis occurring over a distance of thousands of kilometres. Our findings further demonstrate that these events represent potentially dangerous regional phenomena and should be included in tsunami warning systems.

  10. Widespread tsunami-like waves of 23-27 June in the Mediterranean and Black Seas generated by high-altitude atmospheric forcing

    PubMed Central

    Šepić, Jadranka; Vilibić, Ivica; Rabinovich, Alexander B.; Monserrat, Sebastian

    2015-01-01

    A series of tsunami-like waves of non-seismic origin struck several southern European countries during the period of 23 to 27 June 2014. The event caused considerable damage from Spain to Ukraine. Here, we show that these waves were long-period ocean oscillations known as meteorological tsunamis which are generated by intense small-scale air pressure disturbances. An unique atmospheric synoptic pattern was tracked propagating eastward over the Mediterranean and the Black seas in synchrony with onset times of observed tsunami waves. This pattern favoured generation and propagation of atmospheric gravity waves that induced pronounced tsunami-like waves through the Proudman resonance mechanism. This is the first documented case of a chain of destructive meteorological tsunamis occurring over a distance of thousands of kilometres. Our findings further demonstrate that these events represent potentially dangerous regional phenomena and should be included in tsunami warning systems. PMID:26119833

  11. Optical rogue-wave-like extreme value fluctuations in fiber Raman amplifiers.

    PubMed

    Hammani, Kamal; Finot, Christophe; Dudley, John M; Millot, Guy

    2008-10-13

    We report experimental observation and characterization of rogue wave-like extreme value statistics arising from pump-signal noise transfer in a fiber Raman amplifier. Specifically, by exploiting Raman amplification with an incoherent pump, the amplified signal is shown to develop a series of temporal intensity spikes whose peak power follows a power-law probability distribution. The results are interpreted using a numerical model of the Raman gain process using coupled nonlinear Schrödinger equations, and the numerical model predicts results in good agreement with experiment.

  12. Calibration of Wire-Like Manganin Gauges for Use in Planar Shock-Wave Experiments

    NASA Astrophysics Data System (ADS)

    Chapman, David J.; Braithwaite, Christopher H.; Proud, William G.

    2009-12-01

    Piezoresistive gauges have been used extensively for many decades as in-material stress transducers during shock wave experiments. Manganin demonstrates a high piezoresistive response which is relatively temperature independent. As such manganin gauges have been widely calibrated by many authors for use during shock-wave experiments. The precise calibration has been demonstrated to depend on both the chemical composition and mechanical history of the manganin, and on the geometry of the gauge. The research presented in this paper refers to the calibration of a commercially available manganin gauge, Micro-measurements J2M-SS-580SF-025, generally referred to as the T-gauge owing to its geometry. The T-gauge has seen widespread use as a pressure transducer to measure lateral stress during plate-impact experiments. It has been previously proposed that T-gauges have a similar response to the grid foil-like manganin gauges extensively calibrated by Rosenberg et al. However, recently it has been suggested that they in fact behave in a wire-like manner. The results presented here demonstrate that the gauges' behaviour is wire-like when mounted to measure longitudinal stress. A modified calibration can be applied successfully to convert the relative resistance change to the stress normal to the gauge element. These results have important ramifications for the reduction of lateral stress measurements previously made using the T-gauge.

  13. Calibration of Wire-Like Manganin Gauges for Use in Planar Shock-Wave Experiments

    NASA Astrophysics Data System (ADS)

    Chapman, David; Proud, William

    2009-06-01

    Peizoresistive gauges have been used extensively for many decades as in-material stress transducers during shock wave experiments. Manganin demonstrates a high piezoresistive response which is relatively temperature independent. As such manganin gauges have been widely calibrated by many authors for use during shock-wave experiments. The precise calibration has been demonstrated to depend on both the chemical composition and mechanical history of the manganin, and on the geometry of the gauge. The research presented in this paper refers to the calibration of a commercially available manganin gauge, Micro-measurements J2M-SS-580SF-025, generally referred to as the T-gauge owing to its geometry. The T-gauge has seen widespread use as a pressure transducer to measure lateral stress during plate-impact experiments. It has been previously proposed that T-gauges have a similar response to the grid foil-like manganin gauges extensively calibrated by Rosenberg et. al.. However, recently it has been suggested that they in fact behave in a wire-like manner. The results presented here demonstrate that the gauges behaviour is wire-like when mounted to measure longitudinal stress. A modified calibration can be applied successfully to convert the relative resistance change to the stress normal to the gauge element. These results have important ramifications for the reduction of lateral stress measurements previously made using the T-gauge.

  14. Does subthalamic nucleus deep brain stimulation really improve quality of life in Parkinson's disease?

    PubMed

    Gronchi-Perrin, Aline; Viollier, Sarah; Ghika, Joseph; Combremont, Pierre; Villemure, Jean-Guy; Bogousslavsky, Julien; Burkhard, Pierre R; Vingerhoets, François

    2006-09-01

    We investigated the impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on quality of life (QOL) in patients with advanced Parkinson's disease, as self-assessed before and after surgery by completing the Parkinson's Disease Questionnaire (PDQ39). In addition to this prospective evaluation, we asked patients postoperatively to evaluate their preoperative QOL. In the prospective assessment, results showed that patients perceived a general improvement of QOL after the STN DBS. However, when evaluated retrospectively, they tended to overestimate their preoperative functioning, therefore obscuring the improvement found prospectively. This observation highlights the impact of the method used on obtained results when assessing the effects of STN DBS. (c) 2006 Movement Disorder Society.

  15. Deep brain stimulation of the subthalamic nucleus improves pain in Parkinson's disease.

    PubMed

    Pellaprat, Jean; Ory-Magne, Fabienne; Canivet, Cindy; Simonetta-Moreau, Marion; Lotterie, Jean-Albert; Radji, Fatai; Arbus, Christophe; Gerdelat, Angélique; Chaynes, Patrick; Brefel-Courbon, Christine

    2014-06-01

    In Parkinson's disease (PD), chronic pain is a common symptom which markedly affects the quality of life. Some physiological arguments proposed that Deep Brain Stimulation of the Subthalamic Nucleus (STN-DBS) could improve pain in PD. We investigated in 58 PD patients the effect of STN-DBS on pain using the short McGill Pain Questionnaire and other pain parameters such as the Bodily discomfort subscore of the Parkinson's disease Questionnaire 39 and the Unified Parkinson's Disease Rating Scale section II (UPDRS II) item 17. All pain scores were significantly improved 12 months after STN-DBS. This improvement was not correlated with motor improvement, depression scores or L-Dopa reduction. STN-DBS induced a substantial beneficial effect on pain in PD, independently of its motor effects and mood status of patients. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Meteotsunamis, destructive tsunami-like waves: from observations and simulations towards a warning system (MESSI)

    NASA Astrophysics Data System (ADS)

    Sepic, Jadranka; Vilibic, Ivica

    2016-04-01

    Atmospherically-generated tsunami-like waves, also known as meteotsunamis, pose a severe threat for exposed coastlines. Although not as destructive as ordinary tsunamis, several meters high meteotsunami waves can bring destruction, cause loss of human lives and raise panic. For that reason, MESSI, an integrative meteotsunami research & warning project, has been developed and will be presented herein. The project has a threefold base: (1) research of atmosphere-ocean interaction with focus on (i) source processes in the atmosphere, (ii) energy transfer to the ocean and (iii) along-propagation growth of meteotsunami waves; (2) estimation of meteotsunami occurrence rates in past, present and future climate, and mapping of meteotsunami hazard; (3) construction of a meteotsunami warning system prototype, with the latter being the main objective of the project. Due to a great frequency of meteotsunamis and its complex bathymetry which varies from the shallow shelf in the north towards deep pits in the south, with a number of funnel-shaped bays and harbours substantially amplifying incoming tsunami-like waves, the Adriatic, northernmost of the Mediterranean seas, has been chosen as an ideal area for realization of the MESSI project and implementation of the warning system. This warning system will however be designed to allow for a wider applicability and easy-to-accomplish transfer to other endangered locations. The architecture of the warning system will integrate several components: (1) real-time measurements of key oceanographic and atmospheric parameters, (2) coupled atmospheric-ocean models run in real time (warning) mode, and (3) semi-automatic procedures and protocols for warning of civil protection, local authorities and public. The effectiveness of the warning system will be tested over the historic events.

  17. Subthalamic Neural Activity Patterns Anticipate Economic Risk Decisions in Gambling

    PubMed Central

    Rosa, M.; Carpaneto, J.; Priori, A.

    2018-01-01

    Abstract Economic decision-making is disrupted in individuals with gambling disorder, an addictive behavior observed in Parkinson’s disease (PD) patients receiving dopaminergic therapy. The subthalamic nucleus (STN) is involved in the inhibition of impulsive behaviors; however, its role in impulse control disorders and addiction is still unclear. Here, we recorded STN local field potentials (LFPs) in PD patients with and without gambling disorder during an economic decision-making task. Reaction times analysis showed that for all patients, the decision whether to risk preceded task onset. We compared then for both groups the STN LFP preceding high- and low-risk economic decisions. We found that risk avoidance in gamblers correlated with larger STN LFP low-frequency (<12-Hz) fluctuations preceding task onset. In particular, the amplitude of low-frequency LFP fluctuations carried significant information about future decisions. Decisions of patients not affected by gambling disorder were instead not correlated with pretask STN LFP. Our results suggest that STN activity preceding task onset affects risk decisions by preemptively inhibiting attraction to high but unlikely rewards in favor of a long-term payoff. PMID:29445770

  18. Dynamics of human subthalamic neuron phase-locking to motor and sensory cortical oscillations during movement.

    PubMed

    Lipski, Witold J; Wozny, Thomas A; Alhourani, Ahmad; Kondylis, Efstathios D; Turner, Robert S; Crammond, Donald J; Richardson, Robert Mark

    2017-09-01

    Coupled oscillatory activity recorded between sensorimotor regions of the basal ganglia-thalamocortical loop is thought to reflect information transfer relevant to movement. A neuronal firing-rate model of basal ganglia-thalamocortical circuitry, however, has dominated thinking about basal ganglia function for the past three decades, without knowledge of the relationship between basal ganglia single neuron firing and cortical population activity during movement itself. We recorded activity from 34 subthalamic nucleus (STN) neurons, simultaneously with cortical local field potentials and motor output, in 11 subjects with Parkinson's disease (PD) undergoing awake deep brain stimulator lead placement. STN firing demonstrated phase synchronization to both low- and high-beta-frequency cortical oscillations, and to the amplitude envelope of gamma oscillations, in motor cortex. We found that during movement, the magnitude of this synchronization was dynamically modulated in a phase-frequency-specific manner. Importantly, we found that phase synchronization was not correlated with changes in neuronal firing rate. Furthermore, we found that these relationships were not exclusive to motor cortex, because STN firing also demonstrated phase synchronization to both premotor and sensory cortex. The data indicate that models of basal ganglia function ultimately will need to account for the activity of populations of STN neurons that are bound in distinct functional networks with both motor and sensory cortices and code for movement parameters independent of changes in firing rate. NEW & NOTEWORTHY Current models of basal ganglia-thalamocortical networks do not adequately explain simple motor functions, let alone dysfunction in movement disorders. Our findings provide data that inform models of human basal ganglia function by demonstrating how movement is encoded by networks of subthalamic nucleus (STN) neurons via dynamic phase synchronization with cortex. The data also

  19. Lead intoxication induces noradrenaline depletion, motor nonmotor disabilities, and changes in the firing pattern of subthalamic nucleus neurons.

    PubMed

    Sabbar, M; Delaville, C; De Deurwaerdère, P; Benazzouz, A; Lakhdar-Ghazal, N

    2012-05-17

    Lead intoxication has been suggested as a high risk factor for the development of Parkinson disease. However, its impact on motor and nonmotor functions and the mechanism by which it can be involved in the disease are still unclear. In the present study, we studied the effects of lead intoxication on the following: (1) locomotor activity using an open field actimeter and motor coordination using the rotarod test, (2) anxiety behavior using the elevated plus maze, (3) "depression-like" behavior using sucrose preference test, and (4) subthalamic nucleus (STN) neuronal activity using extracellular single unit recordings. Male Sprague-Dawley rats were treated once a day with lead acetate or sodium acetate (20 mg/kg/d i.p.) during 3 weeks. The tissue content of monoamines was used to determine alteration of these systems at the end of experiments. Results show that lead significantly reduced exploratory activity, locomotor activity and the time spent on the rotarod bar. Furthermore, lead induced anxiety but not "depressive-like" behavior. The electrophysiological results show that lead altered the discharge pattern of STN neurons with an increase in the number of bursting and irregular cells without affecting the firing rate. Moreover, lead intoxication resulted in a decrease of tissue noradrenaline content without any change in the levels of dopamine and serotonin. Together, these results show for the first time that lead intoxication resulted in motor and nonmotor behavioral changes paralleled by noradrenaline depletion and changes in the firing activity of STN neurons, providing evidence consistent with the induction of atypical parkinsonian-like deficits. Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

  20. Subthalamic nucleus involvement in executive functions with increased cognitive load: a subthalamic nucleus and anterior cingulate cortex depth recording study.

    PubMed

    Aulická, Stefania Rusnáková; Jurák, Pavel; Chládek, Jan; Daniel, Pavel; Halámek, Josef; Baláž, Marek; Bočková, Martina; Chrastina, Jan; Rektor, Ivan

    2014-10-01

    We studied the appearance of broadband oscillatory changes (ranging 2-45 Hz) induced by a cognitive task with two levels of complexity. The event-related de/synchronizations (ERD/S) in the subthalamic nucleus (STN) and in the anterior cingulate cortex (ACC) were evaluated in an executive function test. Four epilepsy surgery candidates with intracerebral electrodes implanted in the ACC and three Parkinson's disease patients with externalized deep brain stimulation electrodes implanted in the STN participated in the study. A Flanker test (FT) with visual stimuli (arrows) was performed. Subjects reacted to four types of stimuli presented on the monitor by pushing the right or left button: congruent arrows to the right or left side (simple task) and incongruent arrows to the right or left side (more difficult complex task). We explored the activation of STN and the activation of the ACC while processing the FT. Both conditions, i.e. congruent and incongruent, induced oscillatory changes in the ACC and also STN with significantly higher activation during incongruent trial. At variance with the ACC, in the STN not only the ERD beta but also the ERD alpha activity was significantly more activated by the incongruent condition. In line with our earlier studies, the STN appears to be involved in activities linked with increased cognitive load. The specificity and complexity of task-related activation of the STN might indicate the involvement of the STN in processes controlling human behaviour, e.g. in the selection and inhibition of competing alternatives.

  1. Subthalamic nucleus stimulation impairs emotional conflict adaptation in Parkinson's disease.

    PubMed

    Irmen, Friederike; Huebl, Julius; Schroll, Henning; Brücke, Christof; Schneider, Gerd-Helge; Hamker, Fred H; Kühn, Andrea A

    2017-10-01

    The subthalamic nucleus (STN) occupies a strategic position in the motor network, slowing down responses in situations with conflicting perceptual input. Recent evidence suggests a role of the STN in emotion processing through strong connections with emotion recognition structures. As deep brain stimulation (DBS) of the STN in patients with Parkinson's disease (PD) inhibits monitoring of perceptual and value-based conflict, STN DBS may also interfere with emotional conflict processing. To assess a possible interference of STN DBS with emotional conflict processing, we used an emotional Stroop paradigm. Subjects categorized face stimuli according to their emotional expression while ignoring emotionally congruent or incongruent superimposed word labels. Eleven PD patients ON and OFF STN DBS and eleven age-matched healthy subjects conducted the task. We found conflict-induced response slowing in healthy controls and PD patients OFF DBS, but not ON DBS, suggesting STN DBS to decrease adaptation to within-trial conflict. OFF DBS, patients showed more conflict-induced slowing for negative conflict stimuli, which was diminished by STN DBS. Computational modelling of STN influence on conflict adaptation disclosed DBS to interfere via increased baseline activity. © The Author (2017). Published by Oxford University Press.

  2. Subthalamic nucleus deep brain stimulation improves deglutition in Parkinson's disease.

    PubMed

    Ciucci, Michelle R; Barkmeier-Kraemer, Julie M; Sherman, Scott J

    2008-04-15

    Relatively little is known about the role of the basal ganglia in human deglutition. Deep brain stimulation (DBS) affords us a model for examining deglutition in humans with known impairment of the basal ganglia. The purpose of this study was to examine the effects of subthalamic nuclei (STN) DBS on the oral and pharyngeal stages of deglutition in individuals with Parkinson's Disease (PD). It was hypothesized that DBS would be associated with improved deglutition. Within participant, comparisons were made between DBS in the ON and OFF conditions using the dependent variables: pharyngeal transit time, maximal hyoid bone excursion, oral total composite score, and pharyngeal total composite score. Significant improvement occurred for the pharyngeal composite score and pharyngeal transit time in the DBS ON condition compared with DBS OFF. Stimulation of the STN may excite thalamocortical or brainstem targets to sufficiently overcome the bradykinesia/hypokinesia associated with PD and return some pharyngeal stage motor patterns to performance levels approximating those of "normal" deglutition. However, the degree of hyoid bone excursion and oral stage measures did not improve, suggesting that these motor acts may be under the control of different sensorimotor pathways within the basal ganglia. 2007 Movement Disorder Society

  3. Determination of subthalamic nucleus location by quantitative analysis of despiked background neural activity from microelectrode recordings obtained during deep brain stimulation surgery.

    PubMed

    Danish, Shabbar F; Baltuch, Gordon H; Jaggi, Jurg L; Wong, Stephen

    2008-04-01

    Microelectrode recording during deep brain stimulation surgery is a useful adjunct for subthalamic nucleus (STN) localization. We hypothesize that information in the nonspike background activity can help identify STN boundaries. We present results from a novel quantitative analysis that accomplishes this goal. Thirteen consecutive microelectrode recordings were retrospectively analyzed. Spikes were removed from the recordings with an automated algorithm. The remaining "despiked" signals were converted via root mean square amplitude and curve length calculations into "feature profile" time series. Subthalamic nucleus boundaries determined by inspection, based on sustained deviations from baseline for each feature profile, were compared against those determined intraoperatively by the clinical neurophysiologist. Feature profile activity within STN exhibited a sustained rise in 10 of 13 tracks (77%). The sensitivity of STN entry was 60% and 90% for curve length and root mean square amplitude, respectively, when agreement within 0.5 mm of the neurophysiologist's prediction was used. Sensitivities were 70% and 100% for 1 mm accuracy. Exit point sensitivities were 80% and 90% for both features within 0.5 mm and 1.0 mm, respectively. Reproducible activity patterns in deep brain stimulation microelectrode recordings can allow accurate identification of STN boundaries. Quantitative analyses of this type may provide useful adjunctive information for electrode placement in deep brain stimulation surgery.

  4. 78 FR 30307 - Statement of Organization, Functions, and Delegations of Authority

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... leadership, supervision, and management of staff necessary to fully manage the performance of PGO; (4... budgetary and human resource management, and administrative support; (7) directs and coordinates activities...) provides and oversees the delivery of PGO-wide administrative management and support services in the areas...

  5. Delay-induced Turing-like waves for one-species reaction-diffusion model on a network

    NASA Astrophysics Data System (ADS)

    Petit, Julien; Carletti, Timoteo; Asllani, Malbor; Fanelli, Duccio

    2015-09-01

    A one-species time-delay reaction-diffusion system defined on a complex network is studied. Traveling waves are predicted to occur following a symmetry-breaking instability of a homogeneous stationary stable solution, subject to an external nonhomogeneous perturbation. These are generalized Turing-like waves that materialize in a single-species populations dynamics model, as the unexpected byproduct of the imposed delay in the diffusion part. Sufficient conditions for the onset of the instability are mathematically provided by performing a linear stability analysis adapted to time-delayed differential equations. The method here developed exploits the properties of the Lambert W-function. The prediction of the theory are confirmed by direct numerical simulation carried out for a modified version of the classical Fisher model, defined on a Watts-Strogatz network and with the inclusion of the delay.

  6. Planetary wave-like oscillations in the ionosphere retrieved with a longitudinal chain of ionosondes at high northern latitudes

    NASA Astrophysics Data System (ADS)

    Stray, Nora H.; Espy, Patrick J.

    2018-06-01

    This paper examines the influence of neutral dynamics on the high latitude ionosphere. Using a longitudinal chain of ionosondes at high northern latitudes (52°-65° N), planetary wave-like structures were observed in the spatial structure of the peak electron density in the ionosphere. Longitudinal wavenumbers S0, S1 and S2 have been extracted from these variations of the F layer. The observed wave activity in wavenumber one and two does not show any significant correlation with indices of magnetic activity, suggesting that this is not the primary driver. In addition, the motion of the S1 ionospheric wave structures parallels that of the S1 planetary waves observed in the winds of the mesosphere-lower-thermosphere derived from a longitudinal array of SuperDARN meteor-radar wind measurements. The time delay between the motions of the wave structures would indicate a indirect coupling, commensurate with the diffusion to the ionosphere of mesospheric atomic oxygen perturbations.

  7. One-pass deep brain stimulation of dentato-rubro-thalamic tract and subthalamic nucleus for tremor-dominant or equivalent type Parkinson's disease.

    PubMed

    Coenen, Volker Arnd; Rijntjes, Michel; Prokop, Thomas; Piroth, Tobias; Amtage, Florian; Urbach, Horst; Reinacher, Peter Christoph

    2016-04-01

    Refractory tremor in tremor-dominant (TD) or equivalent-type (EQT) idiopathic Parkinson's syndrome (IPS) poses the challenge of choosing the best target region to for deep brain stimulation (DBS). While the subthalamic nucleus is typically chosen in younger patients as the target for dopamine-responsive motor symptoms, it is more complicated if tremor does not (fully) respond under trial conditions. In this report, we present the first results from simultaneous bilateral DBS of the DRT (dentato-rubro-thalamic tract) and the subthalamic nucleus (STN) in two elderly patients with EQT and TD IPS and dopamine-refractory tremor. Two patients received bilateral octopolar DBS electrodes in the STN additionally traversing the DRT region. Achieved electrode positions were determined with helical CT, overlaid onto DTI tractography data, and compared with clinical data of stimulation response. Both patients showed immediate and sustained improvement of their tremor, bilaterally. The proposed approach appears to be safe and feasible and a combined stimulation of the two target regions was performed tailored to the patients' symptoms. Clinically, no neuropsychiatric effects were seen. Our pilot data suggest a viable therapeutic option to treat the subgroup of TD and EQT IPS and with tremor as the predominant symptom. A clinical study to further investigate this approach ( www.clinicaltrials.gov ; NCT02288468) is the focus of our ongoing research.

  8. Age-related disappearance of Mayer-like heart rate waves

    NASA Technical Reports Server (NTRS)

    Jarisch, W. R.; Ferguson, J. J.; Shannon, R. P.; Wei, J. Y.; Goldberger, A. L.

    1987-01-01

    The effect of age on the principal spectral components of heart rate obtained immediately after passive upright tilt was investigated in human subjects who underwent a 60-deg tilt over 9 sec. Two groups were examined, the first of which consisting of healthy male subjects aged 22-26 years, while the second was comprised of subjects aged 65-84 years on no medication; radiograms were recorded continuously beginning just prior to tilt until 3 min posttilt. The results of spectral analysis showed that elderly subjects did not exhibit the Mayer-like heart rate waves (the 0.07-0.09 Hz oscillations) that were present in the spectra of young subjects immediately after passive upright tilt. The findings are consistent with the concept of a 'dysautonomia of aging'. It is suggested that postural stress testing with spectral analysis of heart rate fluctuations may provide a useful way of assessing physiologic vs chronologic age.

  9. One-step electroplating porous graphene oxide electrodes of supercapacitors for ultrahigh capacitance and energy density.

    PubMed

    Wang, Yongjie; Zhu, Jiaqi

    2015-02-06

    An electroplating method was used for the first time to synthesize 3D porous graphene oxide (PGO) architectures, exhibiting ultrahigh capacitance and energy density as electrodes of supercapacitors. Scanning electron microscopy illustrated the porous structures which promoted the stability and alleviated the stacking of the graphene oxide layers. As investigated in a three-electrode supercapacitor cell, PGO electrodes exhibited the maximum capacitance and energy of 973 F · g(-1) and 98.4 Wh · Kg(-1), which are better than current reports and comparable to batteries. At 4 A · g(-1) for high-power applications, PGO electrodes reached a capacitance, energy, and power density of 493 F · g(-1), 49.9 Wh · Kg(-1), and 1700 W · Kg(-1), and they retained ∼97.83% of capacitance after 10 000 charge/discharge processes. Furthermore, when the PGO was bent exaggeratedly, it still displayed identical properties, which is of important significance for supporting wearable devices.

  10. Postoperative apathy can neutralise benefits in quality of life after subthalamic stimulation for Parkinson's disease.

    PubMed

    Martinez-Fernandez, Raul; Pelissier, Pierre; Quesada, Jean-Louis; Klinger, Hélène; Lhommée, Eugénie; Schmitt, Emmanuelle; Fraix, Valerie; Chabardes, Stephan; Mertens, Patrick; Castrioto, Anna; Kistner, Andrea; Broussolle, Emmanuel; Pollak, Pierre; Thobois, Stéphane; Krack, Paul

    2016-03-01

    Subthalamic nucleus deep brain stimulation (STN-DBS) improves motor symptoms of Parkinson's disease, leading to improvement in health-related quality of life (HRQoL). However, an excessive decrease in dopaminergic medication can lead to a withdrawal syndrome with apathy as the predominant feature. The present study aims to assess the impact of postoperative apathy on HRQoL. A cohort of 88 patients who underwent STN-DBS was divided into two groups, those who were apathetic at 1 year and those who were not, as measured by the Starkstein scale. HRQoL was assessed using the Parkinson's disease questionnaire 39 (PDQ-39) and was compared between the two groups. We also compared activities of daily living, motor improvement and motor complications (Unified Parkinson's Disease Rating Scale, UPDRS), depression and anxiety, as well as cognition and drug dosages. Baseline characteristics and postoperative complications were recorded. One year after surgery, 27.1% of patients suffered from apathy. While motor improvement was significant and equivalent in both the apathy (-40.4% of UPDRS motor score) and non-apathy groups (-48.6%), the PDQ-39 score did not improve in the apathy group (-5.5%; p=0.464), whereas it improved significantly (-36.7%; p≤0.001) in the non-apathy group. Change in apathy scores correlated significantly with change in HRQoL scores (r=0.278, p=0.009). Depression and anxiety scores remained unchanged from baseline in the apathy group (p=0.409, p=0.075), while they improved significantly in patients without apathy (p=0.006, p≤0.001). A significant correlation was found between changes in apathy and depression (r=0.594, p≤0.001). The development of apathy after STN-DBS can cancel out the benefits of motor improvement in terms of HRQoL. Systematic evaluation and management of apathy occurring after subthalamic stimulation appears mandatory. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence

  11. Reconciling the influence of task-set switching and motor inhibition processes on stop signal after-effects.

    PubMed

    Anguera, Joaquin A; Lyman, Kyle; Zanto, Theodore P; Bollinger, Jacob; Gazzaley, Adam

    2013-01-01

    Executive response functions can be affected by preceding events, even if they are no longer associated with the current task at hand. For example, studies utilizing the stop signal task have reported slower response times to "GO" stimuli when the preceding trial involved the presentation of a "STOP" signal. However, the neural mechanisms that underlie this behavioral after-effect are unclear. To address this, behavioral and electroencephalography (EEG) measures were examined in 18 young adults (18-30 years) on "GO" trials following a previously "Successful Inhibition" trial (pSI), a previously "Failed Inhibition" trial (pFI), and a previous "GO" trial (pGO). Like previous research, slower response times were observed during both pSI and pFI trials (i.e., "GO" trials that were preceded by a successful and unsuccessful inhibition trial, respectively) compared to pGO trials (i.e., "GO" trials that were preceded by another "GO" trial). Interestingly, response time slowing was greater during pSI trials compared to pFI trials, suggesting executive control is influenced by both task set switching and persisting motor inhibition processes. Follow-up behavioral analyses indicated that these effects resulted from between-trial control adjustments rather than repetition priming effects. Analyses of inter-electrode coherence (IEC) and inter-trial coherence (ITC) indicated that both pSI and pFI trials showed greater phase synchrony during the inter-trial interval compared to pGO trials. Unlike the IEC findings, differential ITC was present within the beta and alpha frequency bands in line with the observed behavior (pSI > pFI > pGO), suggestive of more consistent phase synchrony involving motor inhibition processes during the ITI at a regional level. These findings suggest that between-trial control adjustments involved with task-set switching and motor inhibition processes influence subsequent performance, providing new insights into the dynamic nature of executive control.

  12. Exact traveling wave solutions of fractional order Boussinesq-like equations by applying Exp-function method

    NASA Astrophysics Data System (ADS)

    Rahmatullah; Ellahi, Rahmat; Mohyud-Din, Syed Tauseef; Khan, Umar

    2018-03-01

    We have computed new exact traveling wave solutions, including complex solutions of fractional order Boussinesq-Like equations, occurring in physical sciences and engineering, by applying Exp-function method. The method is blended with fractional complex transformation and modified Riemann-Liouville fractional order operator. Our obtained solutions are verified by substituting back into their corresponding equations. To the best of our knowledge, no other technique has been reported to cope with the said fractional order nonlinear problems combined with variety of exact solutions. Graphically, fractional order solution curves are shown to be strongly related to each other and most importantly, tend to fixate on their integer order solution curve. Our solutions comprise high frequencies and very small amplitude of the wave responses.

  13. Geometric phase coded metasurface: from polarization dependent directive electromagnetic wave scattering to diffusion-like scattering.

    PubMed

    Chen, Ke; Feng, Yijun; Yang, Zhongjie; Cui, Li; Zhao, Junming; Zhu, Bo; Jiang, Tian

    2016-10-24

    Ultrathin metasurface compromising various sub-wavelength meta-particles offers promising advantages in controlling electromagnetic wave by spatially manipulating the wavefront characteristics across the interface. The recently proposed digital coding metasurface could even simplify the design and optimization procedures due to the digitalization of the meta-particle geometry. However, current attempts to implement the digital metasurface still utilize several structural meta-particles to obtain certain electromagnetic responses, and requiring time-consuming optimization especially in multi-bits coding designs. In this regard, we present herein utilizing geometric phase based single structured meta-particle with various orientations to achieve either 1-bit or multi-bits digital metasurface. Particular electromagnetic wave scattering patterns dependent on the incident polarizations can be tailored by the encoded metasurfaces with regular sequences. On the contrast, polarization insensitive diffusion-like scattering can also been successfully achieved by digital metasurface encoded with randomly distributed coding sequences leading to substantial suppression of backward scattering in a broadband microwave frequency. The proposed digital metasurfaces provide simple designs and reveal new opportunities for controlling electromagnetic wave scattering with or without polarization dependence.

  14. Geometric phase coded metasurface: from polarization dependent directive electromagnetic wave scattering to diffusion-like scattering

    PubMed Central

    Chen, Ke; Feng, Yijun; Yang, Zhongjie; Cui, Li; Zhao, Junming; Zhu, Bo; Jiang, Tian

    2016-01-01

    Ultrathin metasurface compromising various sub-wavelength meta-particles offers promising advantages in controlling electromagnetic wave by spatially manipulating the wavefront characteristics across the interface. The recently proposed digital coding metasurface could even simplify the design and optimization procedures due to the digitalization of the meta-particle geometry. However, current attempts to implement the digital metasurface still utilize several structural meta-particles to obtain certain electromagnetic responses, and requiring time-consuming optimization especially in multi-bits coding designs. In this regard, we present herein utilizing geometric phase based single structured meta-particle with various orientations to achieve either 1-bit or multi-bits digital metasurface. Particular electromagnetic wave scattering patterns dependent on the incident polarizations can be tailored by the encoded metasurfaces with regular sequences. On the contrast, polarization insensitive diffusion-like scattering can also been successfully achieved by digital metasurface encoded with randomly distributed coding sequences leading to substantial suppression of backward scattering in a broadband microwave frequency. The proposed digital metasurfaces provide simple designs and reveal new opportunities for controlling electromagnetic wave scattering with or without polarization dependence. PMID:27775064

  15. Complications of subthalamic nucleus stimulation in Parkinson's disease.

    PubMed

    Umemura, Atsushi; Oka, Yuichi; Yamamoto, Kenichi; Okita, Kenji; Matsukawa, Noriyuki; Yamada, Kazuo

    2011-01-01

    Subthalamic nucleus deep brain stimulation (STN-DBS) is effective for medically refractory Parkinson's disease. We retrospectively analyzed complications in 180 consecutive patients who underwent bilateral STN-DBS. Surgery-related complications were symptomatic intracerebral hemorrhage in 2, chronic subdural hematoma in 1, and transient deterioration of medication-induced psychosis in 2 patients. Device-related complications involved device infection in 5, skin erosion in 5, and implantable pulse generator malfunction in 2 patients. All of these patients required surgical repair. Surgery and device-related complications could be reduced with increased surgical experience and the introduction of new surgical equipment and technology. Treatment or stimulation-related complications were intractable dyskinesia/dystonia in 11, problematic dysarthria in 7, apraxia of eyelid opening (ALO) in 11, back pain in 10, and restless leg syndrome in 6 patients. Neuropsychiatric complications were transient mood changes in some, impulse control disorder in 2, severe depression related to excessive reduction of dopaminergic medications in 2, rapid progression of dementia in 1, and suicide attempts in 2 patients. Most complications were mild and transient. Dysarthria and ALO were the most frequent permanent sequelae after STN-DBS. Treatment-related adverse events may be caused not only by the effect of stimulation effect but also excessive reduction of dopaminergic medication, or progression of the disease. In conclusion, STN-DBS seems to be a relatively safe procedure. Although serious complications with permanent sequelae are rare, significant incidences of adverse effects occur. Physicians engaged in this treatment should have a comprehensive understanding of the probable complications and how to avoid them.

  16. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson's disease - two cases

    PubMed Central

    2011-01-01

    Stuttering is a speech disorder with disruption of verbal fluency which is occasionally present in patients with Parkinson's disease (PD). Long-term medical management of PD is frequently complicated by fluctuating motor functions and dyskinesias. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment of motor fluctuations and is the most common surgical procedure in PD. Here we report the re-occurrence and aggravation of stuttering following STN-DBS in two male patients treated for advanced PD. In both patients the speech fluency improved considerably when the neurostimulator was turned off, indicating that stuttering aggravation was related to neurostimulation of the STN itself, its afferent or efferent projections and/or to structures localized in the immediate proximity. This report supports previous studies demonstrating that lesions of the basal ganglia-thalamocortical motor circuit, including the STN, is involved in the development of stuttering. In advanced PD STN-DBS is generally an effective and safe treatment. However, patients with PD and stuttering should be informed about the risk of aggravated symptoms following surgical therapy. PMID:21477305

  17. Subthalamic nucleus stimulation and spontaneous language production in Parkinson's disease: A double laterality problem.

    PubMed

    Batens, Katja; De Letter, Miet; Raedt, Robrecht; Duyck, Wouter; Vanhoutte, Sarah; Van Roost, Dirk; Santens, Patrick

    2015-08-01

    Asymmetric degeneration of dopaminergic neurons, are characteristic for Parkinson's disease (PD). Despite the lateralized representation of language, the correlation of asymmetric degeneration of nigrostriatal networks in PD with language performance has scarcely been examined. The laterality of dopamine depletion influences language deficits in PD and thus modulates the effects of subthalamic nucleus (STN) stimulation on language production. The spontaneous language production of patients with predominant dopamine depletion of the left (PD-left) and right (PD-right) hemisphere was compared in four stimulation conditions. PD-right made comparatively more verb inflection errors than PD-left. Bilateral STN stimulation improves spontaneous language production only for PD-left. The laterality of dopamine depletion influences spontaneous language production and the effect of STN stimulation on linguistic functions. However, it is probably only one of the many variables influencing the effect of STN stimulation on language production. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Non-stationary discharge patterns in motor cortex under subthalamic nucleus deep brain stimulation.

    PubMed

    Santaniello, Sabato; Montgomery, Erwin B; Gale, John T; Sarma, Sridevi V

    2012-01-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) directly modulates the basal ganglia (BG), but how such stimulation impacts the cortex upstream is largely unknown. There is evidence of cortical activation in 6-hydroxydopamine (OHDA)-lesioned rodents and facilitation of motor evoked potentials in Parkinson's disease (PD) patients, but the impact of the DBS settings on the cortical activity in normal vs. Parkinsonian conditions is still debated. We use point process models to analyze non-stationary activation patterns and inter-neuronal dependencies in the motor and sensory cortices of two non-human primates during STN DBS. These features are enhanced after treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which causes a consistent PD-like motor impairment, while high-frequency (HF) DBS (i.e., ≥100 Hz) strongly reduces the short-term patterns (period: 3-7 ms) both before and after MPTP treatment, and elicits a short-latency post-stimulus activation. Low-frequency DBS (i.e., ≤50 Hz), instead, has negligible effects on the non-stationary features. Finally, by using tools from the information theory [i.e., receiver operating characteristic (ROC) curve and information rate (IR)], we show that the predictive power of these models is dependent on the DBS settings, i.e., the probability of spiking of the cortical neurons (which is captured by the point process models) is significantly conditioned on the timely delivery of the DBS input. This dependency increases with the DBS frequency and is significantly larger for high- vs. low-frequency DBS. Overall, the selective suppression of non-stationary features and the increased modulation of the spike probability suggest that HF STN DBS enhances the neuronal activation in motor and sensory cortices, presumably because of reinforcement mechanisms, which perhaps involve the overlap between feedback antidromic and feed-forward orthodromic responses along the BG-thalamo-cortical loop.

  19. Parkinson subtype-specific Granger-causal coupling and coherence frequency in the subthalamic area.

    PubMed

    Florin, Esther; Pfeifer, Johannes; Visser-Vandewalle, Veerle; Schnitzler, Alfons; Timmermann, Lars

    2016-09-22

    Previous work on Parkinson's disease (PD) has indicated a predominantly afferent coupling between affected arm muscle activity and electrophysiological activity within the subthalamic nucleus (STN). So far, no information is available indicating which frequency components drive the afferent information flow in PD patients. Non-directional coupling e.g. by measuring coherence is primarily established in the beta band as well as at tremor frequency. Based on previous evidence it is likely that different subtypes of the disease are associated with different connectivity patterns. Therefore, we determined coherence and causality between local field potentials (LFPs) in the STN and surface electromyograms (EMGs) from the contralateral arm in 18 akinetic-rigid (AR) PD patients and 8 tremor-dominant (TD) PD patients. During the intraoperative recording, patients were asked to lift their forearm contralateral to the recording side. Significantly more afferent connections were detected for the TD patients for tremor-periods and non-tremor-periods combined as well as for only tremor periods. Within the STN 74% and 63% of the afferent connections are associated with coherence from 4-8Hz and 8-12Hz, respectively. However, when considering only tremor-periods significantly more afferent than efferent connections were associated with coherence from 12 to 20Hz across all recording heights. No difference between efferent and afferent connections is seen in the frequency range from 4 to 12Hz for all recording heights. For the AR patients, no significant difference in afferent and efferent connections within the STN was found for the different frequency bands. Still, for the AR patients dorsal of the STN significantly more afferent than efferent connections were associated with coherence in the frequency range from 12 to 16Hz. These results provide further evidence for the differential pathological oscillations and pathways present in AR and TD Parkinson patients. Copyright © 2016

  20. Motor behaviors in the sheep evoked by electrical stimulation of the subthalamic nucleus.

    PubMed

    Lentz, Linnea; Zhao, Yan; Kelly, Matthew T; Schindeldecker, William; Goetz, Steven; Nelson, Dwight E; Raike, Robert S

    2015-11-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is used to treat movement disorders, including advanced Parkinson's disease (PD). The pathogenesis of PD and the therapeutic mechanisms of DBS are not well understood. Large animal models are essential for investigating the mechanisms of PD and DBS. The purpose of this study was to develop a novel sheep model of STN DBS and quantify the stimulation-evoked motor behaviors. To do so, a large sample of animals was chronically-implanted with commercial DBS systems. Neuroimaging and histology revealed that the DBS leads were implanted accurately relative to the neurosurgical plan and also precisely relative to the STN. It was also possible to repeatedly conduct controlled evaluations of stimulation-evoked motor behavior in the awake-state. The evoked motor responses depended on the neuroanatomical location of the electrode contact selected for stimulation, as contacts proximal to the STN evoked movements at significantly lower voltages. Tissue stimulation modeling demonstrated that selecting any of the contacts stimulated the STN, whereas selecting the relatively distal contacts often also stimulated thalamus but only the distal-most contact stimulated internal capsule. The types of evoked motor behaviors were specific to the stimulation frequency, as low but not high frequencies consistently evoked movements resembling human tremor or dyskinesia. Electromyography confirmed that the muscle activity underlying the tremor-like movements in the sheep was consistent with human tremor. Overall, this work establishes that the sheep is a viable a large-animal platform for controlled testing of STN DBS with objective motor outcomes. Moreover, the results support the hypothesis that exaggerated low-frequency activity within individual nodes of the motor network can drive symptoms of human movement disorders, including tremor and dyskinesia. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Wave like signatures in aerosol optical depth and associated radiative impacts over the central Himalayan region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shukla, K. K.; Phanikumar, D. V.; Kumar, K.  Niranjan

    2015-10-01

    In this study, we present a case study on 16 October 2011 to show the first observational evidence of the influence of short period gravity waves in aerosol transport during daytime over the central Himalayan region. The Doppler lidar data has been utilized to address the daytime boundary layer evolution and related aerosol dynamics over the site. Mixing layer height is estimated by wavelet covariance transform method and found to be ~ 0.7 km, AGL. Aerosol optical depth observations during daytime revealed an asymmetry showing clear enhancement during afternoon hours as compared to forenoon. Interestingly, Fourier and wavelet analysis ofmore » vertical velocity and attenuated backscatter showed similar 50-90 min short period gravity wave signatures during afternoon hours. Moreover, our observations showed that gravity waves are dominant within the boundary layer implying that the daytime boundary layer dynamics is playing a vital role in transporting the aerosols from surface to the top of the boundary layer. Similar modulations are also evident in surface parameters like temperature, relative humidity and wind speed indicating these waves are associated with the dynamical aspects over Himalayan region. Finally, time evolution of range-23 height indicator snapshots during daytime showed strong upward velocities especially during afternoon hours implying that convective processes through short period gravity waves plays a significant role in transporting aerosols from the nearby valley region to boundary layer top over the site. These observations also establish the importance of wave induced daytime convective boundary layer dynamics in the lower Himalayan region.« less

  2. From synapse to gene product: Prolonged expression of c-fos induced by a single microinjection of carbachol in the pontomesencephalic tegmentum

    PubMed Central

    Quattrochi, James J.; Bazalakova, Mihaela; Hobson, J. Allan

    2006-01-01

    It is not known how the brain modifies its regulatory systems in response to the application of a drug, especially over the long term of weeks and months. We have developed a model system approach to this question by manipulating cholinergic cell groups of the laterodorsal and pedunculopontine tegmental (LDT/PPT) nuclei in the pontomesencephalic tegmentum (PMT), which are known to be actively involved in the timing and quantity of rapid eye movement (REM) sleep. In a freely moving feline model, a single microinjection of the cholinergic agonist carbachol conjugated to a latex nanosphere delivery system into the caudolateral PMT elicits a long-term enhancement of one distinguishing phasic event of REM sleep, ponto-geniculo-occipital (PGO) waves, lasting 5 days but without any significant change in REM sleep or other behavioral state. Here, we test the hypothesis that cholinergic activation within the caudolateral PMT alters the postsynaptic excitability of the PGO network, stimulating the prolonged expression of c-fos that underlies this long-term PGO enhancement (LTPE) effect. Using quantitative Fos immunohistochemistry, we found that the number of Fos-immunoreactive (Fos-IR) neurons surrounding the caudolateral PMT injection site decreased sharply by postcarbachol day 03, while the number of Fos-IR neurons in the more rostral LDT/PPT increased >30-fold and remained at a high level following the course of LTPE. These results demonstrate a sustained c-fos expression in response to pharmacological stimulation of the brain and suggest that carbachol's acute effects induce LTPE via cholinergic receptors, with subsequent transsynaptic activation of the LDT/PPT maintaining the LTPE effect. PMID:15893601

  3. What neurophysiological recordings tell us about cognitive and behavioral functions of the human subthalamic nucleus.

    PubMed

    Marceglia, Sara; Fumagalli, Manuela; Priori, Alberto

    2011-01-01

    The behavioral implications of deep brain stimulation (DBS) observed in Parkinson's disease patients provided evidence for a possible nonexclusively motor role of the subthalamic nucleus (STN) in basal ganglia circuitry. Basal ganglia pathophysiology can be studied directly by the analysis of neural rhythms measured in local field potentials recorded through DBS electrodes. Recent studies demonstrated that specific oscillations in the STN are involved in cognitive and behavioral information processing: action representation is mediated through β oscillations (13-35 Hz); cognitive information related to decision-making processes is mediated through the low-frequency oscillation (5-12 Hz); and limbic and emotional information is mediated through the α oscillation (8-12 Hz). These results revealed an important involvement of STN in decisional processes, cognitive functions, emotion control and conflict that could explain the post-DBS occurrence of behavioral disturbances.

  4. Insight into capacitive performance of polyaniline/graphene oxide composites with ecofriendly binder

    NASA Astrophysics Data System (ADS)

    Bilal, Salma; Fahim, Muhammad; Firdous, Irum; Ali Shah, Anwar-ul-Haq

    2018-03-01

    The behaviour of gold electrode modified with polyaniline/graphene oxide composites (PGO) was studied for electrochemical and charge storage properties in aqueous acidic media. The surface of gold electrode was modified with aqueous slurry of PGO by using Carboxymethyl cellulose (CMC) as binder. The intercalation of polyaniline in the GO layers, synthesized by in situ polymerization was confirmed by scanning electron microscopy (SEM). The electrochemical behaviour and charge storing properties were investigated using cyclic voltammetry (CV), galvanostatic charge discharge (GCD) and electrochemical impedance spectroscopy (EIS). A high specific capacitance of 1721 F g-1 was obtained for PGO with 69.8% retention of capacitance even after 1000 voltammetric cycles in the potential range of 0-0.9 V at 20 mV s-1. EIS indicated low charge transfer resistance (Rct) and solution resistance (Rs) values of 0.51 Ω and 0.07 Ω, respectively. This good performance of PGO coated electrode is attributed to the use of CMC binder which generate a high electrode/ electrolyte contact area and short path lengths for electronic transport and electrolyte ion.

  5. Multicontrast multiecho FLASH MRI for targeting the subthalamic nucleus.

    PubMed

    Xiao, Yiming; Beriault, Silvain; Pike, G Bruce; Collins, D Louis

    2012-06-01

    The subthalamic nucleus (STN) is one of the most common stimulation targets for treating Parkinson's disease using deep brain stimulation (DBS). This procedure requires precise placement of the stimulating electrode. Common practice of DBS implantation utilizes microelectrode recording to locate the sites with the correct electrical response after an initial location estimate based on a universal human brain atlas that is linearly scaled to the patient's anatomy as seen on the preoperative images. However, this often results in prolonged surgical time and possible surgical complications since the small-sized STN is difficult to visualize on conventional magnetic resonance (MR) images and its intersubject variability is not sufficiently considered in the atlas customization. This paper proposes a multicontrast, multiecho MR imaging (MRI) method that directly delineates the STN and other basal ganglia structures through five co-registered image contrasts (T1-weighted navigation image, R2 map, susceptibility-weighted imaging (phase, magnitude and fusion image)) obtained within a clinically acceptable time. The image protocol was optimized through both simulation and in vivo experiments to obtain the best image quality. Taking advantage of the multiple echoes and high readout bandwidths, no interimage registration is required since all images are produced in one acquisition, and image distortion and chemical shift are reduced. This MRI protocol is expected to mitigate some of the shortcomings of the state-of-the-art DBS implantation methods. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. Gravitational Waves

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, Jonah Maxwell

    This report has slides on Gravitational Waves; Pound and Rebka: A Shocking Fact; Light is a Ruler; Gravity is the Curvature of Spacetime; Gravitational Waves Made Simple; How a Gravitational Wave Affects Stuff Here; LIGO; This Detection: Neutron Stars; What the Gravitational Wave Looks Like; The Sound of Merging Neutron Stars; Neutron Star Mergers: More than GWs; The Radioactive Cloud; The Kilonova; and finally Summary, Multimessenger Astronomy.

  7. Stimulation of the Rat Subthalamic Nucleus is Neuroprotective Following Significant Nigral Dopamine Neuron Loss

    PubMed Central

    Spieles-Engemann, A. L.; Behbehani, M. M.; Collier, T. J.; Wohlgenant, S. L.; Steece-Collier, K.; Paumier, K.; Daley, B. F.; Gombash, S.; Madhavan, L.; Mandybur, G. T.; Lipton, J.W.; Terpstra, B.T.; Sortwell, C.E.

    2010-01-01

    Deep brain stimulation of the subthalamic nucleus (STN-DBS) is efficacious in treating the motor symptoms of Parkinson’s disease (PD). However, the impact of STN-DBS on the progression of PD is unknown. Previous preclinical studies have demonstrated that STN-DBS can attenuate the degeneration of a relatively intact nigrostriatal system from dopamine (DA)-depleting neurotoxins. The present study examined whether STN-DBS can provide neuroprotection in the face of prior significant nigral DA neuron loss similar to PD patients at the time of diagnosis. STN-DBS between two and four weeks after intrastriatal 6-hydroxydopamine (6-OHDA) provided significant sparing of DA neurons in the SN of rats. This effect was not due to inadvertent lesioning of the STN and was dependent upon proper electrode placement. Since STN-DBS appears to have significant neuroprotective properties, initiation of STN-DBS earlier in the course of PD may provide added neuroprotective benefits in addition to its ability to provide symptomatic relief. PMID:20307668

  8. Validity of Single Tract Microelectrode Recording in Subthalamic Nucleus Stimulation

    PubMed Central

    Umemura, Atsushi; Oka, Yuichi; Yamada, Kazuo; Oyama, Genko; Shimo, Yasushi; Hattori, Nobutaka

    2013-01-01

    In surgery for subthalamic nucleus (STN) deep brain stimulation (DBS), precise implantation of the lead into the STN is essential. Physiological refinement with microelectrode recording (MER) is the gold standard for identifying STN. We studied single tract MER findings and surgical outcomes and verified our surgical method using single tract MER. The number of trajectories in MER and the final position of lead placement were retrospectively analyzed in 440 sides of STN DBS in 221 patients. Bilateral STN DBS yielded marked improvement in the motor score, dyskinesia/fluctuation score, and reduced requirement of dopaminergic medication in this series. The number of trajectories required to obtain sufficient activity of the STN was one in 79.0%, two in 18.2%, and three or more in 2.5% of 440 sides. In 92 sides requiring altered trajectory, the final direction of trajectory movement was posterior in 73.9%, anterior in 13.0%, lateral in 5.4%, and medial in 4.3%. In 18 patients, posterior moves were required due to significant brain shift with intracranial air caused by outflow of CSF during the second side procedure. Sufficient STN activity is obtained with minimum trajectories by proper targeting and precise interpretation of MER findings even in the single tract method. Anterior–posterior moves rather than medial–lateral moves should be attempted first in cases with insufficient recording of STN activity. PMID:24140767

  9. Human Subthalamic Nucleus Theta and Beta Oscillations Entrain Neuronal Firing During Sensorimotor Conflict

    PubMed Central

    Zavala, Baltazar; Damera, Srikanth; Dong, Jian Wilson; Lungu, Codrin; Brown, Peter; Zaghloul, Kareem A.

    2017-01-01

    Recent evidence has suggested that prefrontal cortical structures may inhibit impulsive actions during conflict through activation of the subthalamic nucleus (STN). Consistent with this hypothesis, deep brain stimulation to the STN has been associated with altered prefrontal cortical activity and impaired response inhibition. The interactions between oscillatory activity in the STN and its presumably antikinetic neuronal spiking, however, remain poorly understood. Here, we simultaneously recorded intraoperative local field potential and spiking activity from the human STN as participants performed a sensorimotor action selection task involving conflict. We identified several STN neuronal response types that exhibited different temporal dynamics during the task. Some neurons showed early, cue-related firing rate increases that remained elevated longer during high conflict trials, whereas other neurons showed late, movement-related firing rate increases. Notably, the high conflict trials were associated with an entrainment of individual neurons by theta- and beta-band oscillations, both of which have been observed in cortical structures involved in response inhibition. Our data suggest that frequency-specific activity in the beta and theta bands influence STN firing to inhibit impulsivity during conflict. PMID:26494798

  10. The temporal behaviour of MHD waves in a partially ionized prominence-like plasma: Effect of heating and cooling

    NASA Astrophysics Data System (ADS)

    Ballester, J. L.; Carbonell, M.; Soler, R.; Terradas, J.

    2018-01-01

    Context. During heating or cooling processes in prominences, the plasma microscopic parameters are modified due to the change of temperature and ionization degree. Furthermore, if waves are excited on this non-stationary plasma, the changing physical conditions of the plasma also affect wave dynamics. Aims: Our aim is to study how temporal variation of temperature and microscopic plasma parameters modify the behaviour of magnetohydrodynamic (MHD) waves excited in a prominence-like hydrogen plasma. Methods: Assuming optically thin radiation, a constant external heating, the full expression of specific internal energy, and a suitable energy equation, we have derived the profiles for the temporal variation of the background temperature. We have computed the variation of the ionization degree using a Saha equation, and have linearized the single-fluid MHD equations to study the temporal behaviour of MHD waves. Results: For all the MHD waves considered, the period and damping time become time dependent. In the case of Alfvén waves, the cut-off wavenumbers also become time dependent and the attenuation rate is completely different in a cooling or heating process. In the case of slow waves, while it is difficult to distinguish the slow wave properties in a cooling partially ionized plasma from those in an almost fully ionized plasma, the period and damping time of these waves in both plasmas are completely different when the plasma is heated. The temporal behaviour of the Alfvén and fast wave is very similar in the cooling case, but in the heating case, an important difference appears that is related with the time damping. Conclusions: Our results point out important differences in the behaviour of MHD waves when the plasma is heated or cooled, and show that a correct interpretation of the observed prominence oscillations is very important in order to put accurate constraints on the physical situation of the prominence plasma under study, that is, to perform prominence

  11. Identification of the subthalamic nucleus in deep brain stimulation surgery with a novel wavelet-derived measure of neural background activity

    PubMed Central

    Snellings, André; Sagher, Oren; Anderson, David J.; Aldridge, J. Wayne

    2016-01-01

    Object A wavelet-based measure was developed to quantitatively assess neural background activity taken during surgical neurophysiological recordings to localize the boundaries of the subthalamic nucleus during target localization for deep brain stimulator implant surgery. Methods Neural electrophysiological data was recorded from 14 patients (20 tracks, n = 275 individual recording sites) with dopamine-sensitive idiopathic Parkinson’s disease during the target localization portion of deep brain stimulator implant surgery. During intraoperative recording the STN was identified based upon audio and visual monitoring of neural firing patterns, kinesthetic tests, and comparisons between neural behavior and known characteristics of the target nucleus. The quantitative wavelet-based measure was applied off-line using MATLAB software to measure the magnitude of the neural background activity, and the results of this analysis were compared to the intraoperative conclusions. Wavelet-derived estimates were compared to power spectral density measures. Results The wavelet-derived background levels were significantly higher in regions encompassed by the clinically estimated boundaries of the STN than in surrounding regions (STN: 225 ± 61 μV vs. ventral to STN: 112 ± 32 μV, and dorsal to STN: 136 ± 66 μV). In every track, the absolute maximum magnitude was found within the clinically identified STN. The wavelet-derived background levels provided a more consistent index with less variability than power spectral density. Conclusions The wavelet-derived background activity assessor can be calculated quickly, requires no spike sorting, and can be reliably used to identify the STN with very little subjective interpretation required. This method may facilitate rapid intraoperative identification of subthalamic nucleus borders. PMID:19344225

  12. Seismic shear waves as Foucault pendulum

    NASA Astrophysics Data System (ADS)

    Snieder, Roel; Sens-Schönfelder, Christoph; Ruigrok, Elmer; Shiomi, Katsuhiko

    2016-03-01

    Earth's rotation causes splitting of normal modes. Wave fronts and rays are, however, not affected by Earth's rotation, as we show theoretically and with observations made with USArray. We derive that the Coriolis force causes a small transverse component for P waves and a small longitudinal component for S waves. More importantly, Earth's rotation leads to a slow rotation of the transverse polarization of S waves; during the propagation of S waves the particle motion behaves just like a Foucault pendulum. The polarization plane of shear waves counteracts Earth's rotation and rotates clockwise in the Northern Hemisphere. The rotation rate is independent of the wave frequency and is purely geometric, like the Berry phase. Using the polarization of ScS and ScS2 waves, we show that the Foucault-like rotation of the S wave polarization can be observed. This can affect the determination of source mechanisms and the interpretation of observed SKS splitting.

  13. Assessing wave energy effects on biodiversity: the wave hub experience.

    PubMed

    Witt, M J; Sheehan, E V; Bearhop, S; Broderick, A C; Conley, D C; Cotterell, S P; Crow, E; Grecian, W J; Halsband, C; Hodgson, D J; Hosegood, P; Inger, R; Miller, P I; Sims, D W; Thompson, R C; Vanstaen, K; Votier, S C; Attrill, M J; Godley, B J

    2012-01-28

    Marine renewable energy installations harnessing energy from wind, wave and tidal resources are likely to become a large part of the future energy mix worldwide. The potential to gather energy from waves has recently seen increasing interest, with pilot developments in several nations. Although technology to harness wave energy lags behind that of wind and tidal generation, it has the potential to contribute significantly to energy production. As wave energy technology matures and becomes more widespread, it is likely to result in further transformation of our coastal seas. Such changes are accompanied by uncertainty regarding their impacts on biodiversity. To date, impacts have not been assessed, as wave energy converters have yet to be fully developed. Therefore, there is a pressing need to build a framework of understanding regarding the potential impacts of these technologies, underpinned by methodologies that are transferable and scalable across sites to facilitate formal meta-analysis. We first review the potential positive and negative effects of wave energy generation, and then, with specific reference to our work at the Wave Hub (a wave energy test site in southwest England, UK), we set out the methodological approaches needed to assess possible effects of wave energy on biodiversity. We highlight the need for national and international research clusters to accelerate the implementation of wave energy, within a coherent understanding of potential effects-both positive and negative.

  14. Prolonged enhancement of REM sleep produced by carbachol microinjection into the amygdala.

    PubMed

    Calvo, J M; Simón-Arceo, K; Fernández-Mas, R

    1996-01-31

    The effect on sleep organization of carbachol microinjected into different amygdaloid nuclei was analysed in 12 cats. Single carbachol doses of 8 micrograms in 0.50 microliter saline were delivered unilaterally or bilaterally into the central, basal, lateral or basolateral amygdaloid nucleus. Carbachol administration into the central nucleus induced a prolonged (5 days) enhancement of both REM sleep and its preceeding slow wave sleep episodes with PGO waves (sommeil phasique a ondes lentes, SPHOL), which was more pronounced following bilateral than unilateral carbachol administration. However, neither SPHOL nor REM sleep changes were produced by administration of carbachol into the other amygdaloid nuclei. We conclude that cholinergic activation of the central amygdaloid nucleus produces a long-term facilitation of REM sleep occurrence.

  15. Comparison of magnetic resonance imaging sequences for depicting the subthalamic nucleus for deep brain stimulation.

    PubMed

    Nagahama, Hiroshi; Suzuki, Kengo; Shonai, Takaharu; Aratani, Kazuki; Sakurai, Yuuki; Nakamura, Manami; Sakata, Motomichi

    2015-01-01

    Electrodes are surgically implanted into the subthalamic nucleus (STN) of Parkinson's disease patients to provide deep brain stimulation. For ensuring correct positioning, the anatomic location of the STN must be determined preoperatively. Magnetic resonance imaging has been used for pinpointing the location of the STN. To identify the optimal imaging sequence for identifying the STN, we compared images produced with T2 star-weighted angiography (SWAN), gradient echo T2*-weighted imaging, and fast spin echo T2-weighted imaging in 6 healthy volunteers. Our comparison involved measurement of the contrast-to-noise ratio (CNR) for the STN and substantia nigra and a radiologist's interpretations of the images. Of the sequences examined, the CNR and qualitative scores were significantly higher on SWAN images than on other images (p < 0.01) for STN visualization. Kappa value (0.74) on SWAN images was the highest in three sequences for visualizing the STN. SWAN is the sequence best suited for identifying the STN at the present time.

  16. Distinct populations of neurons respond to emotional valence and arousal in the human subthalamic nucleus.

    PubMed

    Sieger, Tomáš; Serranová, Tereza; Růžička, Filip; Vostatek, Pavel; Wild, Jiří; Štastná, Daniela; Bonnet, Cecilia; Novák, Daniel; Růžička, Evžen; Urgošík, Dušan; Jech, Robert

    2015-03-10

    Both animal studies and studies using deep brain stimulation in humans have demonstrated the involvement of the subthalamic nucleus (STN) in motivational and emotional processes; however, participation of this nucleus in processing human emotion has not been investigated directly at the single-neuron level. We analyzed the relationship between the neuronal firing from intraoperative microrecordings from the STN during affective picture presentation in patients with Parkinson's disease (PD) and the affective ratings of emotional valence and arousal performed subsequently. We observed that 17% of neurons responded to emotional valence and arousal of visual stimuli according to individual ratings. The activity of some neurons was related to emotional valence, whereas different neurons responded to arousal. In addition, 14% of neurons responded to visual stimuli. Our results suggest the existence of neurons involved in processing or transmission of visual and emotional information in the human STN, and provide evidence of separate processing of the affective dimensions of valence and arousal at the level of single neurons as well.

  17. Modulation of human time processing by subthalamic deep brain stimulation.

    PubMed

    Wojtecki, Lars; Elben, Saskia; Timmermann, Lars; Reck, Christiane; Maarouf, Mohammad; Jörgens, Silke; Ploner, Markus; Südmeyer, Martin; Groiss, Stefan Jun; Sturm, Volker; Niedeggen, Michael; Schnitzler, Alfons

    2011-01-01

    Timing in the range of seconds referred to as interval timing is crucial for cognitive operations and conscious time processing. According to recent models of interval timing basal ganglia (BG) oscillatory loops are involved in time interval recognition. Parkinsońs disease (PD) is a typical disease of the basal ganglia that shows distortions in interval timing. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a powerful treatment of PD which modulates motor and cognitive functions depending on stimulation frequency by affecting subcortical-cortical oscillatory loops. Thus, for the understanding of BG-involvement in interval timing it is of interest whether STN-DBS can modulate timing in a frequency dependent manner by interference with oscillatory time recognition processes. We examined production and reproduction of 5 and 15 second intervals and millisecond timing in a double blind, randomised, within-subject repeated-measures design of 12 PD-patients applying no, 10-Hz- and ≥ 130-Hz-STN-DBS compared to healthy controls. We found under(re-)production of the 15-second interval and a significant enhancement of this under(re-)production by 10-Hz-stimulation compared to no stimulation, ≥ 130-Hz-STN-DBS and controls. Milliseconds timing was not affected. We provide first evidence for a frequency-specific modulatory effect of STN-DBS on interval timing. Our results corroborate the involvement of BG in general and of the STN in particular in the cognitive representation of time intervals in the range of multiple seconds.

  18. Modulation of Human Time Processing by Subthalamic Deep Brain Stimulation

    PubMed Central

    Timmermann, Lars; Reck, Christiane; Maarouf, Mohammad; Jörgens, Silke; Ploner, Markus; Südmeyer, Martin; Groiss, Stefan Jun; Sturm, Volker; Niedeggen, Michael; Schnitzler, Alfons

    2011-01-01

    Timing in the range of seconds referred to as interval timing is crucial for cognitive operations and conscious time processing. According to recent models of interval timing basal ganglia (BG) oscillatory loops are involved in time interval recognition. Parkinsońs disease (PD) is a typical disease of the basal ganglia that shows distortions in interval timing. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a powerful treatment of PD which modulates motor and cognitive functions depending on stimulation frequency by affecting subcortical-cortical oscillatory loops. Thus, for the understanding of BG-involvement in interval timing it is of interest whether STN-DBS can modulate timing in a frequency dependent manner by interference with oscillatory time recognition processes. We examined production and reproduction of 5 and 15 second intervals and millisecond timing in a double blind, randomised, within-subject repeated-measures design of 12 PD-patients applying no, 10-Hz- and ≥130-Hz-STN-DBS compared to healthy controls. We found under(re-)production of the 15-second interval and a significant enhancement of this under(re-)production by 10-Hz-stimulation compared to no stimulation, ≥130-Hz-STN-DBS and controls. Milliseconds timing was not affected. We provide first evidence for a frequency-specific modulatory effect of STN-DBS on interval timing. Our results corroborate the involvement of BG in general and of the STN in particular in the cognitive representation of time intervals in the range of multiple seconds. PMID:21931767

  19. Mechanism of high growth rate for diamond-like carbon films synthesized by helicon wave plasma chemical vapor deposition

    NASA Astrophysics Data System (ADS)

    Peiyu, JI; Jun, YU; Tianyuan, HUANG; Chenggang, JIN; Yan, YANG; Lanjian, ZHUGE; Xuemei, WU

    2018-02-01

    A high growth rate fabrication of diamond-like carbon (DLC) films at room temperature was achieved by helicon wave plasma chemical vapor deposition (HWP-CVD) using Ar/CH4 gas mixtures. The microstructure and morphology of the films were characterized by Raman spectroscopy and scanning electron microscopy. The diagnosis of plasma excited by a helicon wave was measured by optical emission spectroscopy and a Langmuir probe. The mechanism of high growth rate fabrication for DLC films by HWP-CVD has been discussed. The growth rate of the DLC films reaches a maximum value of 54 μm h-1 at the CH4 flow rate of 85 sccm, which is attributed to the higher plasma density during the helicon wave plasma discharge. The CH and H α radicals play an important role in the growth of DLC films. The results show that the H α radicals are beneficial to the formation and stabilization of C=C bond from sp2 to sp3.

  20. Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans

    PubMed Central

    Tan, Huiling; Pogosyan, Alek; Ashkan, Keyoumars; Green, Alexander L; Aziz, Tipu; Foltynie, Thomas; Limousin, Patricia; Zrinzo, Ludvic; Hariz, Marwan; Brown, Peter

    2016-01-01

    The basal ganglia are known to be involved in the planning, execution and control of gripping force and movement vigour. Here we aim to define the nature of the basal ganglia control signal for force and to decode gripping force based on local field potential (LFP) activities recorded from the subthalamic nucleus (STN) in patients with deep brain stimulation (DBS) electrodes. We found that STN LFP activities in the gamma (55–90 Hz) and beta (13–30m Hz) bands were most informative about gripping force, and that a first order dynamic linear model with these STN LFP features as inputs can be used to decode the temporal profile of gripping force. Our results enhance the understanding of how the basal ganglia control gripping force, and also suggest that deep brain LFPs could potentially be used to decode movement parameters related to force and movement vigour for the development of advanced human-machine interfaces. DOI: http://dx.doi.org/10.7554/eLife.19089.001 PMID:27855780

  1. Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition

    PubMed Central

    Fischer, Petra; Pogosyan, Alek; Herz, Damian M; Cheeran, Binith; Green, Alexander L; Fitzgerald, James; Aziz, Tipu Z; Hyam, Jonathan; Little, Simon; Foltynie, Thomas; Limousin, Patricia; Zrinzo, Ludvic; Brown, Peter; Tan, Huiling

    2017-01-01

    Gamma activity in the subthalamic nucleus (STN) is widely viewed as a pro-kinetic rhythm. Here we test the hypothesis that rather than being specifically linked to movement execution, gamma activity reflects dynamic processing in this nucleus. We investigated the role of gamma during fast stopping and recorded scalp electroencephalogram and local field potentials from deep brain stimulation electrodes in 9 Parkinson’s disease patients. Patients interrupted finger tapping (paced by a metronome) in response to a stop-signal sound, which was timed such that successful stopping would occur only in ~50% of all trials. STN gamma (60–90 Hz) increased most strongly when the tap was successfully stopped, whereas phase-based connectivity between the contralateral STN and motor cortex decreased. Beta or theta power seemed less directly related to stopping. In summary, STN gamma activity may support flexible motor control as it did not only increase during movement execution but also during rapid action-stopping. DOI: http://dx.doi.org/10.7554/eLife.23947.001 PMID:28742498

  2. Speech outcomes in Parkinson's disease after subthalamic nucleus deep brain stimulation: A systematic review.

    PubMed

    Aldridge, Danielle; Theodoros, Deborah; Angwin, Anthony; Vogel, Adam P

    2016-12-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in reducing motor symptoms for many individuals with Parkinson's disease (PD). However, STN DBS does not appear to influence speech in the same way, and may result in a variety of negative outcomes for people with PD (PWP). A high degree of inter-individual variability amongst PWP regarding speech outcomes following STN DBS is evident in many studies. Furthermore, speech studies in PWP following STN DBS have employed a wide variety of designs and methodologies, which complicate comparison and interpretation of outcome data amongst studies within this growing body of research. An analysis of published evidence regarding speech outcomes in PWP following STN DBS, according to design and quality, is missing. This systematic review aimed to analyse and coalesce all of the current evidence reported within observational and experimental studies investigating the effects of STN DBS on speech. It will strengthen understanding of the relationship between STN DBS and speech, and inform future research by highlighting methodological limitations of current evidence. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. SU-E-I-78: Neuromelanin in the Subthalamic Nucleus of Patients with Parkinson's Disease: An Electron Spin Resonance Spectroscopy Study.

    PubMed

    Gomez, J; Salmon, C Garrido; Filho, O Baffa; Santos, J Peixoto; Pitella, J

    2012-06-01

    Parkinson disease and related syndromes are associated directly with the concentrations of neuromelanin, iron and other heavy metals, and nowadays it is discussed the possible protective role of neuromelanin by the sequester redox active iron ions, reducing the formation of free hydroxyl radicals and therefore inactivating the iron ions that induce oxidative stress. The aim of this work is to study the concentration ratios between iron ions and neuromelanin in subthalamic nucleus of patients with Parkinson's disease (PD) using Electron Spin Resonance (ESR). Necropsy samples of subthalamic nucleus from eight human brains were studied: three non-affected by any neurodegenerative disease and five with Parkinson's disease. The samples were stored in formaldehyde and washed with a solution of 0.01 molar of ethylenediaminetetraacetic acid. ESR experiments were development in a JEOL FA-200 X-Band spectrometer at different temperatures between -170° C to room temperature. The relative concentrations of each species were estimated from the double integral values of the fitted spectra. For all samples, ESR spectra showed to be composed of three different signals following the Curie's law. One signal was attributed to high-spin ferric ions (g∼ 4.3) in rhomboedric symmetry, Cu(II) ions (close to g=2.0) and neuromelanin (g∼ 2.01). The ferric ions concentration ratio between patients and controls was 3.0±0.2. The same ratio for neuromelanine was 0.24±0.06. Our preliminary results indicated a significant increment of iron concentration in PD samples which agrees with previous histochemical and biochemical reports. This finding and the clear reduction of neuromelanin concentration in PD samples suggest the possible role of neuromelanin as iron ions storage. © 2012 American Association of Physicists in Medicine.

  4. Investigations of High Pressure Acoustic Waves in Resonators with Seal-Like Features

    NASA Technical Reports Server (NTRS)

    Daniels, Christopher C.; Steinetz, Bruce M.; Finkbeiner, Joshua R.; Li, Xiao-Fan; Raman, Ganesh

    2004-01-01

    1) Standing waves with maximum pressures of 188 kPa have been produced in resonators containing ambient pressure air; 2) Addition of structures inside the resonator shifts the fundamental frequency and decreases the amplitude of the generated pressure waves; 3) Addition of holes to the resonator does reduce the magnitude of the acoustic waves produced, but their addition does not prohibit the generation of large magnitude non-linear standing waves; 4) The feasibility of reducing leakage using non-linear acoustics has been confirmed.

  5. Individual fiber anatomy of the subthalamic region revealed with diffusion tensor imaging: a concept to identify the deep brain stimulation target for tremor suppression.

    PubMed

    Coenen, Volker A; Mädler, Burkhard; Schiffbauer, Hagen; Urbach, Horst; Allert, Niels

    2011-04-01

    Deep brain stimulation (DBS) has been proven to alleviate tremor of various origins. Distinct regions have been targeted. One explanation for good clinical tremor control might be the involvement of the dentatorubrothalamic tract (DRT) as has been suggested in superficial (thalamic) and inferior (posterior subthalamic) target regions. Beyond a correlation with atlas data and the postmortem evaluation of patients treated with lesion surgery, proof for the involvement of DRT in tremor reduction in the living, the scope of this work, is elusive. To report a case of unilateral refractory tremor in tremor-dominant Parkinson disease treated with thalamic DBS. Preoperative diffusion tensor imaging (DTI) was performed. Correlation with individual DBS electrode contact locations was obtained through postoperative fusion of helical computed tomography (CT) data with DTI fiber tracking. Tremor was alleviated effectively. An evaluation of the active electrode contact position revealed clear involvement of the DRT in tremor control. A closer evaluation of clinical effects and side effects revealed a highly detailed individual fiber map of the subthalamic region with DTI fiber tracking. This is the first time the involvement of the DRT in tremor reduction through DBS has been shown in the living. The combination of DTI with postoperative CT and the evaluation of the electrophysiological environment of distinct electrode contacts led to an individual detailed fiber map and might be extrapolated to refined DTI-based targeting strategies in the future. Data acquisition for a larger study group is the topic of our ongoing research.

  6. Alcohol preference influences the subthalamic nucleus control on motivation for alcohol in rats.

    PubMed

    Lardeux, Sylvie; Baunez, Christelle

    2008-02-01

    In addition to its role in motor and attentional processes, the subthalamic nucleus (STN) has also been recently demonstrated to be involved in motivational function. Indeed, bilateral STN lesions modulate differentially the motivation for natural rewards and drugs of abuse, increasing motivation for food and decreasing motivation for cocaine in rats. Here, we show that in outbred rats, the STN can modulate the motivation for alcohol according to alcohol preference, without affecting alcohol intake. When performed on 'High-Drinker' rats, STN lesions enhanced the breaking point (BP) under a progressive ratio schedule of reinforcement and increased the time spent in the environment previously paired with alcohol access in the place preference paradigm. In contrast, when performed on 'Low-Drinker' rats, STN lesions decreased the BP and increased the time spent in the environment paired with water. These results show that STN lesions enhance the motivation for alcohol in rats showing a high alcohol preference, whereas they decrease it in rats showing a low preference for alcohol. These results suggest that the STN plays a complex role in the reward circuit, that is not limited to a

  7. Structural and functional connectivity of the subthalamic nucleus during vocal emotion decoding

    PubMed Central

    Frühholz, Sascha; Ceravolo, Leonardo; Grandjean, Didier

    2016-01-01

    Our understanding of the role played by the subthalamic nucleus (STN) in human emotion has recently advanced with STN deep brain stimulation, a neurosurgical treatment for Parkinson’s disease and obsessive-compulsive disorder. However, the potential presence of several confounds related to pathological models raises the question of how much they affect the relevance of observations regarding the physiological function of the STN itself. This underscores the crucial importance of obtaining evidence from healthy participants. In this study, we tested the structural and functional connectivity between the STN and other brain regions related to vocal emotion in a healthy population by combining diffusion tensor imaging and psychophysiological interaction analysis from a high-resolution functional magnetic resonance imaging study. As expected, we showed that the STN is functionally connected to the structures involved in emotional prosody decoding, notably the orbitofrontal cortex, inferior frontal gyrus, auditory cortex, pallidum and amygdala. These functional results were corroborated by probabilistic fiber tracking, which revealed that the left STN is structurally connected to the amygdala and the orbitofrontal cortex. These results confirm, in healthy participants, the role played by the STN in human emotion and its structural and functional connectivity with the brain network involved in vocal emotions. PMID:26400857

  8. Camptocormia and deep brain stimulation: The interesting overlapping etiologies and the therapeutic role of subthalamic nucleus-deep brain stimulation in Parkinson disease with camptocormia.

    PubMed

    Ekmekci, Hakan; Kaptan, Hulagu

    2016-01-01

    Camptocormia is known as "bent spine syndrome" and defined as a forward hyperflexion. The most common etiologic factor is related with the movement disorders, mainly in Parkinson's disease (PD). We present the case of a 51-year-old woman who has been followed with PD for the last 10 years, and also under the therapy for PD. An unappreciated correlation low back pain with camptocormia developed. She underwent deep brain stimulation (DBS) in the subthalamic nucleus bilaterally and improved her bending posture. The relationship between the DBS and camptocormia is discussed in this unique condition.

  9. Gravitational Waves from Stellar Black Hole Binaries and the Impact on Nearby Sun-like Stars

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lopes, Ilídio; Silk, Joseph, E-mail: ilidio.lopes@tecnico.ulisboa.pt, E-mail: silk@astro.ox.ac.uk

    We investigate the impact of resonant gravitational waves on quadrupole acoustic modes of Sun-like stars located nearby stellar black hole binary systems (such as GW150914 and GW151226). We find that the stimulation of the low-overtone modes by gravitational radiation can lead to sizeable photometric amplitude variations, much larger than the predictions for amplitudes driven by turbulent convection, which in turn are consistent with the photometric amplitudes observed in most Sun-like stars. For accurate stellar evolution models, using up-to-date stellar physics, we predict photometric amplitude variations of 1–10{sup 3} ppm for a solar mass star located at a distance between 1more » au and 10 au from the black hole binary and belonging to the same multi-star system. The observation of such a phenomenon will be within the reach of the Plato mission because the telescope will observe several portions of the Milky Way, many of which are regions of high stellar density with a substantial mixed population of Sun-like stars and black hole binaries.« less

  10. Photoelectron wave function in photoionization: plane wave or Coulomb wave?

    PubMed

    Gozem, Samer; Gunina, Anastasia O; Ichino, Takatoshi; Osborn, David L; Stanton, John F; Krylov, Anna I

    2015-11-19

    The calculation of absolute total cross sections requires accurate wave functions of the photoelectron and of the initial and final states of the system. The essential information contained in the latter two can be condensed into a Dyson orbital. We employ correlated Dyson orbitals and test approximate treatments of the photoelectron wave function, that is, plane and Coulomb waves, by comparing computed and experimental photoionization and photodetachment spectra. We find that in anions, a plane wave treatment of the photoelectron provides a good description of photodetachment spectra. For photoionization of neutral atoms or molecules with one heavy atom, the photoelectron wave function must be treated as a Coulomb wave to account for the interaction of the photoelectron with the +1 charge of the ionized core. For larger molecules, the best agreement with experiment is often achieved by using a Coulomb wave with a partial (effective) charge smaller than unity. This likely derives from the fact that the effective charge at the centroid of the Dyson orbital, which serves as the origin of the spherical wave expansion, is smaller than the total charge of a polyatomic cation. The results suggest that accurate molecular photoionization cross sections can be computed with a modified central potential model that accounts for the nonspherical charge distribution of the core by adjusting the charge in the center of the expansion.

  11. What is dorso-lateral in the subthalamic Nucleus (STN)?--a topographic and anatomical consideration on the ambiguous description of today's primary target for deep brain stimulation (DBS) surgery.

    PubMed

    Coenen, Volker A; Prescher, Andreas; Schmidt, Thorsten; Picozzi, Piero; Gielen, Frans L H

    2008-11-01

    The most frequently used target for DBS in advanced Parkinson Disease (PD) is the sensorimotor subthalamic nucleus (STN), anatomically referred to as dorso-lateral STN [3]. Ambiguities arise, regarding the true meaning of this description in the STN. Does "dorsal" indicate posterior or superior? At its best, this definition assigns two directions in space to a three-dimensional structure. This paper evaluates the ambiguity and describes the sensorimotor part of the STN in stereotactic space.

  12. Stimulation of the subthalamic nucleus and impulsivity: release your horses.

    PubMed

    Ballanger, Benedicte; van Eimeren, Thilo; Moro, Elena; Lozano, Andres M; Hamani, Clement; Boulinguez, Philippe; Pellecchia, Giovanna; Houle, Sylvain; Poon, Yu Yan; Lang, Anthony E; Strafella, Antonio P

    2009-12-01

    In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute to certain impulsive behavior during high-conflict decisions. A neurocomputational model of the basal ganglia has recently been proposed that suggests this behavioral aspect may be related to the role played by the STN in relaying a "hold your horses" signal intended to allow more time to settle on the best option. The aim of the present study was 2-fold: 1) to extend these observations by providing evidence that the STN may influence and prevent the execution of any response even during low-conflict decisions; and 2) to identify the neural correlates of this effect. We measured regional cerebral blood flow during a Go/NoGo and a control (Go) task to study the motor improvement and response inhibition deficits associated with STN-DBS in patients with PD. Although it improved Unified Parkinson Disease Rating Scale motor ratings and induced a global decrease in reaction time during task performance, STN-DBS impaired response inhibition, as revealed by an increase in commission errors in NoGo trials. These behavioral effects were accompanied by changes in synaptic activity consisting of a reduced activation in the cortical networks responsible for reactive and proactive response inhibition. The present results suggest that although it improves motor functions in PD patients, modulation of STN hyperactivity with DBS may tend at the same time to favor the appearance of impulsive behavior by acting on the gating mechanism involved in response initiation.

  13. Changes in regional blood flow induced by unilateral subthalamic nucleus stimulation in patients with Parkinson's disease.

    PubMed

    Tanei, Takafumi; Kajita, Yasukazu; Nihashi, Takashi; Kaneoke, Yoshiki; Takebayashi, Shigenori; Nakatsubo, Daisuke; Wakabayashi, Toshihiko

    2009-11-01

    Changes in regional cerebral blood flow (rCBF) induced by unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) were investigated in 7 consecutive patients with Parkinson's disease, 4 men and 3 women (mean age 62.3 +/- 8.1 years), who underwent rCBF measurement by N-isopropyl-p-(iodine-123)-iodoamphetamine single photon emission computed tomography at rest before and after unilateral STN DBS preoperatively in the on-drug condition, and postoperatively in the on-drug and on-stimulation condition. Statistical parametric mapping was used to identify significant changes in rCBF from the preoperative to the postoperative conditions. rCBF was increased in the bilateral cingulate cortices and bilateral cerebellar hemispheres. rCBF was decreased in the bilateral medial frontal cortices and left superior temporal cortex. Unilateral STN DBS produced rCBF changes in the bilateral cingulate cortices, cerebellar hemispheres, and medial frontal cortices. These findings indicate that unilateral STN DBS affects rCBF in both hemispheres.

  14. Beating HF waves to generate VLF waves in the ionosphere

    NASA Astrophysics Data System (ADS)

    Kuo, Spencer; Snyder, Arnold; Kossey, Paul; Chang, Chia-Lie; Labenski, John

    2012-03-01

    Beat-wave generation of very low frequency (VLF) waves by two HF heaters in the ionosphere is formulated theoretically and demonstrated experimentally. The heater-induced differential thermal pressure force and ponderomotive force, which dominate separately in the D and F regions of the ionosphere, drive an electron current for the VLF emission. A comparison, applying appropriate ionospheric parameters shows that the ponderomotive force dominates in beat-wave generation of VLF waves. Three experiments, one in the nighttime in the absence of D and E layers and two in the daytime in the presence of D and E layers, were performed. X mode HF heaters of slightly different frequencies were transmitted at CW full power. VLF waves at 10 frequencies ranging from 3.5 to 21.5 kHz were generated. The frequency dependencies of the daytime and nighttime radiation intensities are quite similar, but the nighttime radiation is much stronger than the daytime one at the same radiation frequency. The intensity ratio is as large as 9 dB at 11.5 kHz. An experiment directly comparing VLF waves generated by the beat-wave approach and by the amplitude modulation (AM) approach was also conducted. The results rule out the likely contribution of the AM mechanism acting on the electrojet and indicate that beat-wave in the VLF range prefers to be generated in the F region of the ionosphere through the ponderomotive nonlinearity, consistent with the theory. In the nighttime experiment, the ionosphere was underdense to the HF heaters, suggesting a likely setting for effective beat-wave generation of VLF waves by the HF heaters.

  15. What controls the mass transport by mode-2 internal solitary-like waves?

    NASA Astrophysics Data System (ADS)

    Deepwell, David; Stastna, Marek

    2016-04-01

    Horizontally propagating internal waves are a regular occurrence in the coastal ocean. Their most commonly observed vertical structure is mode-1 in which isopycnals rise and fall in concert at all depths. Second mode waves, where isopycnals expand from and contract toward the pycnocline centre, have been found in recent observations to occur more frequently than previously thought. For the more common convex configuration, these waves mix the pycnocline, and under certain conditions form recirculating cores which efficiently transport material. In the laboratory, mode-2 waves are easily formed by releasing a mixed region into an ambient stratification. Using high resolution, three dimensional, direct numerical simulations of a laboratory configuration we describe the mass transport efficiency of mode-2 waves under a variety of different parameter regimes and initializations. We identify pycnocline configurations for which transport is especially efficient, and explore the structure of recirculating cores during their formation, propagation and disintegration and its implications on mass transport.

  16. Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease: Indications of a principal role of the brainstem.

    PubMed

    Holiga, Štefan; Mueller, Karsten; Möller, Harald E; Urgošík, Dušan; Růžička, Evžen; Schroeter, Matthias L; Jech, Robert

    2015-01-01

    During implantation of deep-brain stimulation (DBS) electrodes in the target structure, neurosurgeons and neurologists commonly observe a "microlesion effect" (MLE), which occurs well before initiating subthalamic DBS. This phenomenon typically leads to a transitory improvement of motor symptoms of patients suffering from Parkinson's disease (PD). Mechanisms behind MLE remain poorly understood. In this work, we exploited the notion of ranking to assess spontaneous brain activity in PD patients examined by resting-state functional magnetic resonance imaging in response to penetration of DBS electrodes in the subthalamic nucleus. In particular, we employed a hypothesis-free method, eigenvector centrality (EC), to reveal motor-communication-hubs of the highest rank and their reorganization following the surgery; providing a unique opportunity to evaluate the direct impact of disrupting the PD motor circuitry in vivo without prior assumptions. Penetration of electrodes was associated with increased EC of functional connectivity in the brainstem. Changes in connectivity were quantitatively related to motor improvement, which further emphasizes the clinical importance of the functional integrity of the brainstem. Surprisingly, MLE and DBS were associated with anatomically different EC maps despite their similar clinical benefit on motor functions. The DBS solely caused an increase in connectivity of the left premotor region suggesting separate pathophysiological mechanisms of both interventions. While the DBS acts at the cortical level suggesting compensatory activation of less affected motor regions, the MLE affects more fundamental circuitry as the dysfunctional brainstem predominates in the beginning of PD. These findings invigorate the overlooked brainstem perspective in the understanding of PD and support the current trend towards its early diagnosis.

  17. Distinct populations of neurons respond to emotional valence and arousal in the human subthalamic nucleus

    PubMed Central

    Sieger, Tomáš; Serranová, Tereza; Růžička, Filip; Vostatek, Pavel; Wild, Jiří; Šťastná, Daniela; Bonnet, Cecilia; Novák, Daniel; Růžička, Evžen; Urgošík, Dušan; Jech, Robert

    2015-01-01

    Both animal studies and studies using deep brain stimulation in humans have demonstrated the involvement of the subthalamic nucleus (STN) in motivational and emotional processes; however, participation of this nucleus in processing human emotion has not been investigated directly at the single-neuron level. We analyzed the relationship between the neuronal firing from intraoperative microrecordings from the STN during affective picture presentation in patients with Parkinson’s disease (PD) and the affective ratings of emotional valence and arousal performed subsequently. We observed that 17% of neurons responded to emotional valence and arousal of visual stimuli according to individual ratings. The activity of some neurons was related to emotional valence, whereas different neurons responded to arousal. In addition, 14% of neurons responded to visual stimuli. Our results suggest the existence of neurons involved in processing or transmission of visual and emotional information in the human STN, and provide evidence of separate processing of the affective dimensions of valence and arousal at the level of single neurons as well. PMID:25713375

  18. FDG-PET study of the bilateral subthalamic nucleus stimulation effects on the regional cerebral metabolism in advanced Parkinson disease.

    PubMed

    Li, D; Zuo, C; Guan, Y; Zhao, Y; Shen, J; Zan, S; Sun, B

    2006-01-01

    The aim of the study was to evaluate the changes in regional cerebral metabolic rate of glucose (rCMRGlu) induced by bilateral subthalamic nucleurs (STN) stimulation in advanced Parkinson's disease (PD). 18F-Fluorodeoxyglucose (FDG) PET data obtained before and one month after stimulation were analyzed with statistical parametric mapping (SPM). As a result of clinically effective bilateral STN stimulation, rCMRGlu increased in lateral globus pallidus (GP), upper brain stem, dorsolateral prefrontal cortex (DLPFC) and posterior parietal-occipital cortex, and decreased in the orbital frontal cortex and parahippocampus gyrus (p < 0.001). We conclude that the alleviation of clinical symptoms in advanced PD by bilateral STN stimulation may be the result of activation of both ascending and descending pathways from STN and of restoration of the impaired higher-order cortex functions.

  19. Targeting the subthalamic nucleus in a preclinical model of alcohol use disorder.

    PubMed

    Pelloux, Yann; Baunez, Christelle

    2017-07-01

    The subthalamic nucleus (STN) has only recently been considered to have a role in reward processing. In rats, inactivation of the STN by lesion or high-frequency stimulation (HFS) decreases motivation for cocaine but increases motivation for sucrose. For ethanol, the effect of STN lesion depends on the individual's baseline intake; decreasing motivation for ethanol in rats with lower ethanol intake, while increasing motivation for ethanol in rats with higher-but still limited-ethanol intake. However, the involvement of the STN in behaviour more closely resembling some aspects of alcohol use disorder has not been assessed. This study aimed to determine the effect of STN lesions on the escalation of ethanol intake, subsequent increases in the motivation to "work" for ethanol and the choice of ethanol over a non-drug alternative. We found that STN lesion prevented increases in ethanol intake observed during intermittent ethanol access and after a long period of ethanol privation. STN lesion also decreased the motivation to work for ethanol after escalated intake. Surprisingly, STN lesion increased the choice of alcohol over saccharin. This was associated with a blunting of the hedonic responses to the taste of the reinforcement alternatives. These results evidence the involvement of the STN in different ethanol-motivated behaviours and therefore position the STN as an interesting target for the treatment of alcohol use disorders.

  20. 7T MRI subthalamic nucleus atlas for use with 3T MRI.

    PubMed

    Milchenko, Mikhail; Norris, Scott A; Poston, Kathleen; Campbell, Meghan C; Ushe, Mwiza; Perlmutter, Joel S; Snyder, Abraham Z

    2018-01-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor symptoms in most patients with Parkinson disease (PD), yet may produce untoward effects. Investigation of DBS effects requires accurate localization of the STN, which can be difficult to identify on magnetic resonance images collected with clinically available 3T scanners. The goal of this study is to develop a high-quality STN atlas that can be applied to standard 3T images. We created a high-definition STN atlas derived from seven older participants imaged at 7T. This atlas was nonlinearly registered to a standard template representing 56 patients with PD imaged at 3T. This process required development of methodology for nonlinear multimodal image registration. We demonstrate mm-scale STN localization accuracy by comparison of our 3T atlas with a publicly available 7T atlas. We also demonstrate less agreement with an earlier histological atlas. STN localization error in the 56 patients imaged at 3T was less than 1 mm on average. Our methodology enables accurate STN localization in individuals imaged at 3T. The STN atlas and underlying 3T average template in MNI space are freely available to the research community. The image registration methodology developed in the course of this work may be generally applicable to other datasets.

  1. Complex repetitive behavior: punding after bilateral subthalamic nucleus stimulation in Parkinson's disease.

    PubMed

    Pallanti, Stefano; Bernardi, Silvia; Raglione, Laura Maria; Marini, Paolo; Ammannati, Franco; Sorbi, Sandro; Ramat, Silvia

    2010-07-01

    "Punding" is the term used to describe a stereotyped motor behavior characterized by an intense fascination with repetitive purposeless movements, such as taking apart mechanical objects, handling common objects as if they were new and entertaining, constantly picking at oneself, etc. As a phenomenon with both impulsive and compulsive features, the phenomenology of punding is currently being questioned. In order to investigate the pathophysiology of this phenomenon, we screened a population of Parkinson's disease (PD) outpatients who underwent subthalamic nucleus deep brain stimulation (STN DBS). We conducted a patient-and-relative-completed survey with 24 consecutive patients in an academic outpatient care center, using a modified version of a structured interview. Patients were administered the Unified Parkinson's Disease Rating Scale (UPDRS), the Obsessive-Compulsive Inventory and the Sheehan Disability Scale. Five (20.8%) of the 24 subjects were identified as punders, including three men (60%) and two women. The punders were comparable to the non-punders in terms of clinical and demographic factors. The punder and non-punder groups only differed statistically with regard to the length of time from DBS implantation. Those findings suggest that punding might be induced by STN DBS, and its rate of occurrence in DBS population seems to be more common than previously suspected. Copyright 2010 Elsevier Ltd. All rights reserved.

  2. Effect of unilateral versus bilateral electrostimulation in subthalamic nucleus on speech in Parkinsons disease

    NASA Astrophysics Data System (ADS)

    Wang, Emily; Verhagen Metman, Leo; Bakay, Roy; Arzbaecher, Jean; Bernard, Bryan

    2004-05-01

    Previously, it was found that 16 right-handed patients with idiopathic Parkinsons disease who underwent unilateral implantation of deep brain stimulator in subthalamic nucleus (STN) showed significant improvement in their nonspeech motor functions. Eight of the 16 patients had stimulator in the left STN and eight in the right STN. In contrast, their speech function showed very mild improvement that was limited to the respiratory/phonotory subsystems. Further, there seemed a trend that the patients with right STN stimulation did better than those with left STN stimulation. It was speculated that the difference might be due to a micro lesion caused by the surgical procedure to the corticobulbar fibers run in the left internal capsule. This paper reports speech changes associated with bilateral DBS in STN in four of the 16 subjects who elected to have deep brain stimulator implanted in STN on the opposite side of the brain at a later time. Results show negative changes in speech after bilateral DBS in STN. The changes were not limited to the micro lesion effect due to the surgery itself, but also related to the active stimulation on the dominant hemisphere for speech processing. [Work supported by NIH.

  3. The Striatum and Subthalamic Nucleus as Independent and Collaborative Structures in Motor Control

    PubMed Central

    Tewari, Alia; Jog, Rachna; Jog, Mandar S.

    2016-01-01

    The striatum and the subthalamic nucleus (STN) are two separate input structures into the basal ganglia (BG). Accordingly, research to date has primarily focused on the distinct roles of these structures in motor control and cognition, often through investigation of Parkinson’s disease (PD). Both structures are divided into sensorimotor, associative, and limbic subdivisions based on cortical connectivity. The more recent discovery of the STN as an input structure into the BG drives comparison of these two structures and their respective roles in cognition and motor control. This review compares the role of the striatum and STN in motor response inhibition and execution, competing motor programs, feedback based learning, and response planning. Through comparison, it is found that the striatum and STN have highly independent roles in motor control but also collaborate in order to execute desired actions. There is also the possibility that inhibition or activation of one of these structures indirectly contributes to the function of other connected anatomical structures. Both structures contribute to selective motor response inhibition, which forms the basis of many tasks, but the STN additionally contributes to global inhibition through the hyperdirect pathway. Research is warranted on the functional connectivity of the network for inhibition involving the rIFG, preSMA, striatum, and STN. PMID:26973474

  4. Human Subthalamic Nucleus Theta and Beta Oscillations Entrain Neuronal Firing During Sensorimotor Conflict.

    PubMed

    Zavala, Baltazar; Damera, Srikanth; Dong, Jian Wilson; Lungu, Codrin; Brown, Peter; Zaghloul, Kareem A

    2017-01-01

    Recent evidence has suggested that prefrontal cortical structures may inhibit impulsive actions during conflict through activation of the subthalamic nucleus (STN). Consistent with this hypothesis, deep brain stimulation to the STN has been associated with altered prefrontal cortical activity and impaired response inhibition. The interactions between oscillatory activity in the STN and its presumably antikinetic neuronal spiking, however, remain poorly understood. Here, we simultaneously recorded intraoperative local field potential and spiking activity from the human STN as participants performed a sensorimotor action selection task involving conflict. We identified several STN neuronal response types that exhibited different temporal dynamics during the task. Some neurons showed early, cue-related firing rate increases that remained elevated longer during high conflict trials, whereas other neurons showed late, movement-related firing rate increases. Notably, the high conflict trials were associated with an entrainment of individual neurons by theta- and beta-band oscillations, both of which have been observed in cortical structures involved in response inhibition. Our data suggest that frequency-specific activity in the beta and theta bands influence STN firing to inhibit impulsivity during conflict. Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  5. Neuronal Activity in the Subthalamic Cerebrovasodilator Area under Partial-Gravity Conditions in Rats

    PubMed Central

    Zeredo, Jorge L.; Toda, Kazuo; Kumei, Yasuhiro

    2014-01-01

    The reduced-gravity environment in space is known to cause an upward shift in body fluids and thus require cardiovascular adaptations in astronauts. In this study, we recorded in rats the neuronal activity in the subthalamic cerebrovasodilator area (SVA), a key area that controls cerebral blood flow (CBF), in response to partial gravity. “Partial gravity” is the term that defines the reduced-gravity levels between 1 g (the unit gravity acceleration on Earth) and 0 g (complete weightlessness in space). Neuronal activity was recorded telemetrically through chronically implanted microelectrodes in freely moving rats. Graded levels of partial gravity from 0.4 g to 0.01 g were generated by customized parabolic-flight maneuvers. Electrophysiological signals in each partial-gravity phase were compared to those of the preceding 1 g level-flight. As a result, SVA neuronal activity was significantly inhibited by the partial-gravity levels of 0.15 g and lower, but not by 0.2 g and higher. Gravity levels between 0.2–0.15 g could represent a critical threshold for the inhibition of neurons in the rat SVA. The lunar gravity (0.16 g) might thus trigger neurogenic mechanisms of CBF control. This is the first study to examine brain electrophysiology with partial gravity as an experimental parameter. PMID:25370031

  6. Method and apparatus for assessing material properties of sheet-like materials

    DOEpatents

    Telschow, Kenneth L.; Deason, Vance A.

    2002-01-01

    Apparatus for producing an indication of a material property of a sheet-like material according to the present invention may comprise an excitation source for vibrating the sheet-like material to produce at least one traveling wave therein. A light source configured to produce an object wavefront and a reference wavefront directs the object wavefront toward the sheet-like material to produce a modulated object wavefront. A modulator operatively associated with the reference wavefront modulates the reference wavefront in synchronization with the traveling wave on the sheet-like material to produce a modulated reference wavefront. A sensing medium positioned to receive the modulated object wavefront and the modulated reference wavefront produces an image of the traveling wave in the sheet-like material, the image of the anti-symmetric traveling wave being related to a displacement amplitude of the anti-symmetric traveling wave over a two-dimensional area of the vibrating sheet-like material. A detector detects the image of the traveling wave in the sheet-like material.

  7. Effects of Subthalamic Stimulation on Olfactory Function in Parkinson Disease.

    PubMed

    Cury, Rubens Gisbert; Carvalho, Margarete de Jesus; Lasteros, Fernando Jeyson Lopez; Dias, Alice Estevo; Dos Santos Ghilardi, Maria Gabriela; Paiva, Anderson Rodrigues Brandão; Coutinho, Artur Martins; Buchpiguel, Carlos Alberto; Teixeira, Manoel J; Barbosa, Egberto Reis; Fonoff, Erich Talamoni

    2018-06-01

    Olfactory dysfunction is a nonmotor symptom of Parkinson disease (PD) associated with reduction in quality of life. There is no evidence on whether improvements in olfaction after subthalamic deep brain stimulation (STN-DBS) may be directly attributable to motor improvement or whether this reflects a direct effect of DBS on olfactory brain areas. The aim of the present study was to evaluate the effect of DBS on olfactory function in PD, as well as to explore the correlation between these changes and changes in motor symptoms and brain metabolism. Thirty-two patients with PD were screened for STN-DBS. Patients were evaluated before and 1 year after surgery. Primary outcome was the change in olfactory function (Sniffin' Sticks odor-identification test [SST]) after surgery among the patients with hyposmia at baseline. Secondary outcomes included the relationship between motor outcomes and olfactory changes and [ 18 F]fluorodeoxyglucose-positron emission tomography analysis between subgroups with improvement versus no improvement of smell. STN-DBS improved SST after surgery (preoperative SST, median 7.3 ± 2.4 vs. postoperative SST, median 8.2 ± 2.1; P = 0.045) in a subset of patients among 29 of 32 patients who presented with hyposmia at baseline. The improvement in SST was correlated with DBS response (r = 0.424; P = 0.035). There was also an increase in glucose metabolism in the midbrain, cerebellum, and right frontal lobe in patients with SST improvement (P < 0.001). STN-DBS improves odor identification in a subset of patients with PD. Motor improvement together with changes in the brain metabolism may be linked to this improvement. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. Bilateral stimulation of the subthalamic nucleus has differential effects on reactive and proactive inhibition and conflict-induced slowing in Parkinson's disease.

    PubMed

    Obeso, Ignacio; Wilkinson, Leonora; Rodríguez-Oroz, Maria-Cruz; Obeso, Jose A; Jahanshahi, Marjan

    2013-05-01

    It has been proposed that the subthalamic nucleus (STN) mediates response inhibition and conflict resolution through the fronto-basal ganglia pathways. Our aim was to compare the effects of deep brain stimulation (DBS) of the STN on reactive and proactive inhibition and conflict resolution in Parkinson's disease using a single task. We used the conditional Stop signal reaction time task that provides the Stop signal reaction time (SSRT) as a measure of reactive inhibition, the response delay effect (RDE) as a measure of proactive inhibition and conflict-induced slowing (CIS) as a measure of conflict resolution. DBS of the STN significantly prolonged SSRT relative to stimulation off. However, while the RDE measure of proactive inhibition was not significantly altered by DBS of the STN, relative to healthy controls, RDE was significantly lower with DBS off but not DBS on. DBS of the STN did not alter the mean CIS but produced a significant differential effect on the slowest and fastest RTs on conflict trials, further prolonging the slowest RTs on the conflict trials relative to DBS off and to controls. These results are the first demonstration, using a single task in the same patient sample, that DBS of the STN produces differential effects on reactive and proactive inhibition and on conflict resolution, suggesting that these effects are likely to be mediated through the impact of STN stimulation on different fronto-basal ganglia pathways: hyperdirect, direct and indirect.

  9. Extreme waves under Hurricane Ivan.

    PubMed

    Wang, David W; Mitchell, Douglas A; Teague, William J; Jarosz, Ewa; Hulbert, Mark S

    2005-08-05

    Hurricane Ivan, a category 4 storm, passed directly over six wave-tide gauges deployed by the Naval Research Laboratory on the outer continental shelf in the northeastern Gulf of Mexico. Waves were observed with significant wave heights reaching 17.9 meters and maximum crest-to-trough individual wave heights of 27.7 meters (91 feet). Analysis suggests that significant wave heights likely surpassed 21 meters (69 feet) and that maximum crest-to-trough individual wave heights exceeded 40 meters (132 feet) near the eyewall.

  10. Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease: Indications of a principal role of the brainstem

    PubMed Central

    Holiga, Štefan; Mueller, Karsten; Möller, Harald E.; Urgošík, Dušan; Růžička, Evžen; Schroeter, Matthias L.; Jech, Robert

    2015-01-01

    During implantation of deep-brain stimulation (DBS) electrodes in the target structure, neurosurgeons and neurologists commonly observe a “microlesion effect” (MLE), which occurs well before initiating subthalamic DBS. This phenomenon typically leads to a transitory improvement of motor symptoms of patients suffering from Parkinson's disease (PD). Mechanisms behind MLE remain poorly understood. In this work, we exploited the notion of ranking to assess spontaneous brain activity in PD patients examined by resting-state functional magnetic resonance imaging in response to penetration of DBS electrodes in the subthalamic nucleus. In particular, we employed a hypothesis-free method, eigenvector centrality (EC), to reveal motor-communication-hubs of the highest rank and their reorganization following the surgery; providing a unique opportunity to evaluate the direct impact of disrupting the PD motor circuitry in vivo without prior assumptions. Penetration of electrodes was associated with increased EC of functional connectivity in the brainstem. Changes in connectivity were quantitatively related to motor improvement, which further emphasizes the clinical importance of the functional integrity of the brainstem. Surprisingly, MLE and DBS were associated with anatomically different EC maps despite their similar clinical benefit on motor functions. The DBS solely caused an increase in connectivity of the left premotor region suggesting separate pathophysiological mechanisms of both interventions. While the DBS acts at the cortical level suggesting compensatory activation of less affected motor regions, the MLE affects more fundamental circuitry as the dysfunctional brainstem predominates in the beginning of PD. These findings invigorate the overlooked brainstem perspective in the understanding of PD and support the current trend towards its early diagnosis. PMID:26509113

  11. Subthalamic nucleus deep brain stimulation impacts language in early Parkinson's disease.

    PubMed

    Phillips, Lara; Litcofsky, Kaitlyn A; Pelster, Michael; Gelfand, Matthew; Ullman, Michael T; Charles, P David

    2012-01-01

    Although deep brain stimulation (DBS) of the basal ganglia improves motor outcomes in Parkinson's disease (PD), its effects on cognition, including language, remain unclear. This study examined the impact of subthalamic nucleus (STN) DBS on two fundamental capacities of language, grammatical and lexical functions. These functions were tested with the production of regular and irregular past-tenses, which contrast aspects of grammatical (regulars) and lexical (irregulars) processing while controlling for multiple potentially confounding factors. Aspects of the motor system were tested by contrasting the naming of manipulated (motor) and non-manipulated (non-motor) objects. Performance was compared between healthy controls and early-stage PD patients treated with either DBS/medications or medications alone. Patients were assessed on and off treatment, with controls following a parallel testing schedule. STN-DBS improved naming of manipulated (motor) but not non-manipulated (non-motor) objects, as compared to both controls and patients with just medications, who did not differ from each other across assessment sessions. In contrast, STN-DBS led to worse performance at regulars (grammar) but not irregulars (lexicon), as compared to the other two subject groups, who again did not differ. The results suggest that STN-DBS negatively impacts language in early PD, but may be specific in depressing aspects of grammatical and not lexical processing. The finding that STN-DBS affects both motor and grammar (but not lexical) functions strengthens the view that both depend on basal ganglia circuitry, although the mechanisms for its differential impact on the two (improved motor, impaired grammar) remain to be elucidated.

  12. Subthalamic Nucleus Deep Brain Stimulation Impacts Language in Early Parkinson's Disease

    PubMed Central

    Phillips, Lara; Litcofsky, Kaitlyn A.; Pelster, Michael; Gelfand, Matthew

    2012-01-01

    Although deep brain stimulation (DBS) of the basal ganglia improves motor outcomes in Parkinson's disease (PD), its effects on cognition, including language, remain unclear. This study examined the impact of subthalamic nucleus (STN) DBS on two fundamental capacities of language, grammatical and lexical functions. These functions were tested with the production of regular and irregular past-tenses, which contrast aspects of grammatical (regulars) and lexical (irregulars) processing while controlling for multiple potentially confounding factors. Aspects of the motor system were tested by contrasting the naming of manipulated (motor) and non-manipulated (non-motor) objects. Performance was compared between healthy controls and early-stage PD patients treated with either DBS/medications or medications alone. Patients were assessed on and off treatment, with controls following a parallel testing schedule. STN-DBS improved naming of manipulated (motor) but not non-manipulated (non-motor) objects, as compared to both controls and patients with just medications, who did not differ from each other across assessment sessions. In contrast, STN-DBS led to worse performance at regulars (grammar) but not irregulars (lexicon), as compared to the other two subject groups, who again did not differ. The results suggest that STN-DBS negatively impacts language in early PD, but may be specific in depressing aspects of grammatical and not lexical processing. The finding that STN-DBS affects both motor and grammar (but not lexical) functions strengthens the view that both depend on basal ganglia circuitry, although the mechanisms for its differential impact on the two (improved motor, impaired grammar) remain to be elucidated. PMID:22880117

  13. Stimulation of contacts in ventral but not dorsal subthalamic nucleus normalizes response switching in Parkinson's disease

    PubMed Central

    Greenhouse, Ian; Gould, Sherrie; Houser, Melissa; Aron, Adam R.

    2014-01-01

    Switching between responses is a key executive function known to rely on the frontal cortex and the basal ganglia. Here we aimed to establish with greater anatomical specificity whether such switching could be mediated via different possible frontal–basal-ganglia circuits. Accordingly, we stimulated dorsal vs. ventral contacts of electrodes in the subthalamic nucleus (STN) in Parkinson's patients during switching performance, and also studied matched controls. The patients underwent three sessions: once with bilateral dorsal contact stimulation, once with bilateral ventral contact stimulation, and once Off stimulation. Patients Off stimulation showed abnormal patterns of switching, and stimulation of the ventral contacts but not the dorsal contacts normalized the pattern of behavior relative to controls. This provides some of the first evidence in humans that stimulation of dorsal vs. ventral STN DBS contacts has differential effects on executive function. As response switching is an executive function known to rely on prefrontal cortex, these results suggest that ventral contact stimulation affected an executive/associative cortico-basal ganglia circuit. PMID:23562963

  14. Waking and dreaming consciousness: Neurobiological and functional considerations

    PubMed Central

    Hobson, J.A.; Friston, K.J.

    2012-01-01

    This paper presents a theoretical review of rapid eye movement sleep with a special focus on pontine-geniculate-occipital waves and what they might tell us about the functional anatomy of sleep and consciousness. In particular, we review established ideas about the nature and purpose of sleep in terms of protoconsciousness and free energy minimization. By combining these theoretical perspectives, we discover answers to some fundamental questions about sleep: for example, why is homeothermy suspended during sleep? Why is sleep necessary? Why are we not surprised by our dreams? What is the role of synaptic regression in sleep? The imperatives for sleep that emerge also allow us to speculate about the functional role of PGO waves and make some empirical predictions that can, in principle, be tested using recent advances in the modeling of electrophysiological data. PMID:22609044

  15. Large-scale bedforms induced by supercritical flows and wave-wave interference in the intertidal zone (Cap Ferret, France)

    NASA Astrophysics Data System (ADS)

    Vaucher, Romain; Pittet, Bernard; Humbert, Thomas; Ferry, Serge

    2017-11-01

    The Cap Ferret sand spit is situated along the wave-dominated, tidally modulated Atlantic coast of western France, characterized by a semidiurnal macrotidal range. It displays peculiar dome-like bedforms that can be observed at low tide across the intertidal zone. These bedforms exhibit a wavelength of ca. 1.2 m and an elevation of ca. 30 cm. They occur only when the incident wave heights reach 1.5-2 m. The internal stratifications are characterized by swaley-like, sub-planar, oblique-tangential, oblique-tabular, as well as hummocky-like stratifications. The tabular and tangential stratifications comprise prograding oblique sets (defined as foresets and backsets) that almost always show variations in their steepness. Downcutting into the bottomsets of the oblique-tangential stratifications is common. The sets of laminae observed in the bedforms share common characteristics with those formed by supercritical flows in flume experiments of earlier studies. These peculiar bedforms are observed at the surf-swash transition zone where the backwash flow reaches supercritical conditions. This type of flow can explain their internal architecture but not their general dome-like (three-dimensional) morphology. Wave-wave interference induced by the geomorphology (i.e. tidal channel) of the coastal environment is proposed as explanation for the localized formation of such bedforms. This study highlights that the combination of supercritical flows occurring in the surf-swash transition zone and wave-wave interferences can generate dome-like bedforms in intertidal zones.

  16. Large-scale bedforms induced by supercritical flows and wave-wave interference in the intertidal zone (Cap Ferret, France)

    NASA Astrophysics Data System (ADS)

    Vaucher, Romain; Pittet, Bernard; Humbert, Thomas; Ferry, Serge

    2018-06-01

    The Cap Ferret sand spit is situated along the wave-dominated, tidally modulated Atlantic coast of western France, characterized by a semidiurnal macrotidal range. It displays peculiar dome-like bedforms that can be observed at low tide across the intertidal zone. These bedforms exhibit a wavelength of ca. 1.2 m and an elevation of ca. 30 cm. They occur only when the incident wave heights reach 1.5-2 m. The internal stratifications are characterized by swaley-like, sub-planar, oblique-tangential, oblique-tabular, as well as hummocky-like stratifications. The tabular and tangential stratifications comprise prograding oblique sets (defined as foresets and backsets) that almost always show variations in their steepness. Downcutting into the bottomsets of the oblique-tangential stratifications is common. The sets of laminae observed in the bedforms share common characteristics with those formed by supercritical flows in flume experiments of earlier studies. These peculiar bedforms are observed at the surf-swash transition zone where the backwash flow reaches supercritical conditions. This type of flow can explain their internal architecture but not their general dome-like (three-dimensional) morphology. Wave-wave interference induced by the geomorphology (i.e. tidal channel) of the coastal environment is proposed as explanation for the localized formation of such bedforms. This study highlights that the combination of supercritical flows occurring in the surf-swash transition zone and wave-wave interferences can generate dome-like bedforms in intertidal zones.

  17. Patients' expectations in subthalamic nucleus deep brain stimulation surgery for Parkinson disease.

    PubMed

    Hasegawa, Harutomo; Samuel, Michael; Douiri, Abdel; Ashkan, Keyoumars

    2014-12-01

    Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established treatment for patients with advanced Parkinson disease. However, some patients feel less satisfied with the outcome of surgery. We sought to study the relationship between expectations, satisfaction, and outcome in STN DBS for Parkinson disease. Twenty-two consecutive patients undergoing STN DBS completed a modified 39-item Parkinson disease questionnaire (PDQ-39) preoperatively and 6 months postoperatively. A satisfaction questionnaire accompanied the postoperative questionnaire. Patients expected a significant improvement from surgery preoperatively: preoperative score (median PDQ-39 summary score [interquartile range]): 37.0 (9.5), expected postoperative score: 13.0 (8.0), P < 0.001. Patients improved after surgery (preoperative score 39.0 [11.5], postoperative score 25.0 [14.3], P = 0.003), although there was a substantial disparity between the expected change (24.0 [15.0]) and actual change (14.0 [22.5]), P = 0.008. However, most patients felt that surgery fulfilled their expectations (mean score on a 0%-100% visual analog scale); (75.3 ± 17.8) and were satisfied (73.3 ± 25.3). Satisfaction correlated with fulfillment of expectations (r = 0.910, P < 0.001) but not with quantitative changes in PDQ-39 scores. Addressing patients' expectations both preoperatively and postoperatively may play an important role in patient satisfaction, and therefore overall success, of STN DBS surgery for Parkinson disease. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Dissociable Effects of Subthalamic Stimulation in Obsessive Compulsive Disorder on Risky Reward and Loss Prospects.

    PubMed

    Voon, Valerie; Droux, Fabien; Chabardes, Stephan; Bougerol, Thierry; Kohl, Sina; David, Olivier; Krack, Paul; Polosan, Mircea

    2018-07-01

    Our daily decisions involve an element of risk, a behavioral process that is potentially modifiable. Here we assess the role of the associative-limbic subthalamic nucleus (STN) in obsessive compulsive disorder (OCD) testing on and off deep-brain stimulation (DBS) on anticipatory risk taking to obtain rewards and avoid losses. We assessed 12 OCD STN DBS in a randomized double-blind within-subject cross-over design. STN DBS decreased risk taking to rewards (p = 0.02) and greater risk taking to rewards was positively correlated with OCD severity (p = 0.01) and disease duration (p = 0.01). STN DBS was also associated with impaired subjective discrimination of loss magnitude (p < 0.05), an effect mediated by acute DBS rather than chronic DBS. We highlight a role for the STN in mediating dissociable valence prospects on risk seeking. STN stimulation decreases risk taking to rewards and impairs discrimination of loss magnitude. These findings may have implications for behavioral symptoms related to STN DBS and the potential for STN DBS for the treatment of psychiatric disorders. Copyright © 2018. Published by Elsevier Ltd.

  19. Supergranular waves revisited

    NASA Astrophysics Data System (ADS)

    Langfellner, Jan; Birch, Aaron; Gizon, Laurent

    2017-08-01

    Solar supergranules remain a mysterious phenomenon, half a century after their discovery. One particularly interesting aspect of supergranulation is its wave-like nature detected in Fourier space. Using SDO/HMI local helioseismology and granulation tracking, we provide new evidence for supergranular waves. We also discuss their influence on the evolution of the network magnetic field using cork simulations.

  20. Photoelectron wave function in photoionization: Plane wave or Coulomb wave? [Does photoionization of neutral targets produce Coulomb or plane waves?

    DOE PAGES

    Gozem, Samer; Gunina, Anastasia O.; Ichino, Takatoshi; ...

    2015-10-28

    The calculation of absolute total cross sections requires accurate wave functions of the photoelectron and of the initial and final states of the system. The essential information contained in the latter two can be condensed into a Dyson orbital. We employ correlated Dyson orbitals and test approximate treatments of the photoelectron wave function, that is, plane and Coulomb waves, by comparing computed and experimental photoionization and photodetachment spectra. We find that in anions, a plane wave treatment of the photoelectron provides a good description of photodetachment spectra. For photoionization of neutral atoms or molecules with one heavy atom, the photoelectronmore » wave function must be treated as a Coulomb wave to account for the interaction of the photoelectron with the +1 charge of the ionized core. For larger molecules, the best agreement with experiment is often achieved by using a Coulomb wave with a partial (effective) charge smaller than unity. This likely derives from the fact that the effective charge at the centroid of the Dyson orbital, which serves as the origin of the spherical wave expansion, is smaller than the total charge of a polyatomic cation. Finally, the results suggest that accurate molecular photoionization cross sections can be computed with a modified central potential model that accounts for the nonspherical charge distribution of the core by adjusting the charge in the center of the expansion.« less

  1. Localised surface plasmon-like resonance generated by microwave electromagnetic waves in pipe defects

    NASA Astrophysics Data System (ADS)

    Alobaidi, Wissam M.; Nima, Zeid A.; Sandgren, Eric

    2018-01-01

    Localised surface plasmon (LSP)-like resonance phenomena were simulated in COMSOL Multiphysics™, and the electric field enhancement was evaluated in eight pipe defects using the microwave band from 1.80 to 3.00 GHz and analysed by finite element analysis (FEA). The simulation was carried out, in each defect case, on a pipe that has 762 mm length and 152.4 mm inner diameter, and 12.7 mm pipe wall thickness. Defects were positioned in the middle of the pipe and were named as follows; SD: Square Defect, FCD: fillet corner defect, FD: fillet defect, HCD: half circle defect, TCD: triangle corner defect, TD: triangle defect, ZD: zigzag defect, GD: gear defect. The LSP electric field, and scattering parametric (S21, and S11) waves were evaluated in all cases and found to be strongly dependent on the size and the shape of the defect rather than the pipe and or the medium materials.

  2. Correlated waves of actin filaments and PIP3 in Dictyostelium cells.

    PubMed

    Asano, Yukako; Nagasaki, Akira; Uyeda, Taro Q P

    2008-12-01

    Chemotaxis-deficient amiB-null mutant Dictyostelium cells show two distinct movements: (1) they extend protrusions randomly without net displacements; (2) they migrate persistently and unidirectionally in a keratocyte-like manner. Here, we monitored the intracellular distribution of phosphatidylinositol (3,4,5)-trisphosphate (PIP(3)) to gain insight into roles PIP(3) plays in those spontaneous motilities. In keratocyte-like cells, PIP(3) showed convex distribution over the basal membrane, with no anterior enrichment. In stalled cells, as well as in wild type cells, PIP(3) repeated wave-like changes, including emergence, expansion and disappearance, on the basal membrane. The waves induced lamellipodia when they approached the cell edge, and the advancing speed of the waves was comparable to the migration speed of the keratocyte-like cells. LY294002, an inhibitor of PI3 kinase, abolished PIP(3) waves in stalled cells and stopped keratocyte-like cells. These results together suggested that keratocyte-like cells are "surfing" on the PIP(3) waves by coupling steady lamellipodial protrusions to the PIP(3) waves. Simultaneous live observation of actin filaments and PIP(3) in wild type or stalled amiB(-) cells indicated that the PIP(3) waves were correlated with wave-like distributions of actin filaments. Most notably, PIP(3) waves often followed actin waves, suggesting that PIP(3) induces local depolymerization of actin filaments. Consistent with this idea, cortical accumulation of PIP(3) was often correlated with local retraction of the periphery. We propose that the waves of PIP(3) and actin filaments are loosely coupled with each other and play important roles in generating spontaneous cell polarity. Copyright 2008 Wiley-Liss, Inc.

  3. Gravitational wave-Gauge field oscillations

    NASA Astrophysics Data System (ADS)

    Caldwell, R. R.; Devulder, C.; Maksimova, N. A.

    2016-09-01

    Gravitational waves propagating through a stationary gauge field transform into gauge field waves and back again. When multiple families of flavor-space locked gauge fields are present, the gravitational and gauge field waves exhibit novel dynamics. At high frequencies, the system behaves like coupled oscillators in which the gravitational wave is the central pacemaker. Due to energy conservation and exchange among the oscillators, the wave amplitudes lie on a multidimensional sphere, reminiscent of neutrino flavor oscillations. This phenomenon has implications for cosmological scenarios based on flavor-space locked gauge fields.

  4. Isolation of a conjugative F-like plasmid from a multidrug-resistant Escherichia coli strain CM6 using tandem shock wave-mediated transformation.

    PubMed

    Soto-Alonso, G; Cruz-Medina, J A; Caballero-Pérez, J; Arvizu-Hernández, I; Ávalos-Esparza, L M; Cruz-Hernández, A; Romero-Gómez, S; Rodríguez, A L; Pastrana-Martínez, X; Fernández, F; Loske, A M; Campos-Guillén, J

    2015-07-01

    Genetic characterization of plasmids from bacterial strains provides insight about multidrug resistance. Ten wild type Escherichia coli (E. coli) strains isolated from cow fecal samples were characterized by their antibiotic resistance profile, plasmid patterns and three different identification methods. From one of the strains, a fertility factor-like plasmid was replicated using tandem shock wave-mediated transformation. Underwater shock waves with a positive pressure peak of up to approximately 40 MPa, followed by a pressure trough of approximately -19 MPa were generated using an experimental piezoelectric shock wave source. Three different shock wave energies and a fixed delay of 750 μs were used to study the relationship between energy and transformation efficiency (TE), as well as the influence of shock wave energy on the integrity of the plasmid. Our results showed that the mean shock wave-mediated TE and the integrity of the large plasmid (~70 kb) were reduced significantly at the energy levels tested. The sequencing analysis of the plasmid revealed a high identity to the pHK17a plasmid, including the replication system, which was similar to the plasmid incompatibility group FII. It also showed that it carried an extended spectrum beta-lactamase gene, ctx-m-14. Furthermore, diverse genes for the conjugative mechanism were identified. Our results may be helpful in improving methodologies for conjugative plasmid transfer and directly selecting the most interesting plasmids from environmental samples. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Reduced noradrenergic innervation of ventral midbrain dopaminergic cell groups and the subthalamic nucleus in MPTP-treated parkinsonian monkeys.

    PubMed

    Masilamoni, Gunasingh Jeyaraj; Groover, Olivia; Smith, Yoland

    2017-04-01

    There is anatomical and functional evidence that ventral midbrain dopaminergic (DA) cell groups and the subthalamic nucleus (STN) receive noradrenergic innervation in rodents, but much less is known about these interactions in primates. Degeneration of NE neurons in the locus coeruleus (LC) and related brainstem NE cell groups is a well-established pathological feature of Parkinson's disease (PD), but the development of such pathology in animal models of PD has been inconsistent across species and laboratories. We recently demonstrated 30-40% neuronal loss in the LC, A5 and A6 NE cell groups of rhesus monkeys rendered parkinsonian by chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In this study, we used dopamine-beta-hydroxylase (DβH) immunocytochemistry to assess the impact of this neuronal loss on the number of NE terminal-like varicosities in the substantia nigra pars compacta (SNC), ventral tegmental area (VTA), retrorubral field (RRF) and STN of MPTP-treated parkinsonian monkeys. Our findings reveal that the NE innervation of the ventral midbrain and STN of normal monkeys is heterogeneously distributed being far more extensive in the VTA, RRF and dorsal tier of the SNC than in the ventral SNC and STN. In parkinsonian monkeys, all regions underwent a significant (~50-70%) decrease in NE innervation. At the electron microscopic level, some DβH-positive terminals formed asymmetric axo-dendritic synapses in VTA and STN. These findings demonstrate that the VTA, RRF and SNCd are the main ventral midbrain targets of ascending NE inputs, and that these connections undergo a major break-down in chronically MPTP-treated parkinsonian monkeys. This severe degeneration of the ascending NE system may contribute to the pathophysiology of ventral midbrain and STN neurons in PD. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Subthalamic nucleus deep brain stimulation improves somatosensory function in Parkinson's disease.

    PubMed

    Aman, Joshua E; Abosch, Aviva; Bebler, Maggie; Lu, Chia-Hao; Konczak, Jürgen

    2014-02-01

    An established treatment for the motor symptoms of Parkinson's disease (PD) is deep brain stimulation (DBS) of the subthalamic nucleus (STN). Mounting evidence suggests that PD is also associated with somatosensory deficits, yet the effect of STN-DBS on somatosensory processing is largely unknown. This study investigated whether STN-DBS affects somatosensory processing, specifically the processing of tactile and proprioceptive cues, by systematically examining the accuracy of haptic perception of object size. (Haptic perception refers to one's ability to extract object features such as shape and size by active touch.) Without vision, 13 PD patients with implanted STN-DBS and 13 healthy controls haptically explored the heights of 2 successively presented 3-dimensional (3D) blocks using a precision grip. Participants verbally indicated which block was taller and then used their nonprobing hand to motorically match the perceived size of the comparison block. Patients were tested during ON and OFF stimulation, following a 12-hour medication washout period. First, when compared to controls, the PD group's haptic discrimination threshold during OFF stimulation was elevated by 192% and mean hand aperture error was increased by 105%. Second, DBS lowered the haptic discrimination threshold by 26% and aperture error decreased by 20%. Third, during DBS ON, probing with the motorically more affected hand decreased haptic precision compared to probing with the less affected hand. This study offers the first evidence that STN-DBS improves haptic precision, further indicating that somatosensory function is improved by STN-DBS. We conclude that DBS-related improvements are not explained by improvements in motor function alone, but rather by enhanced somatosensory processing. © 2013 Movement Disorder Society.

  7. Mathematical investigation of tsunami-like long waves interaction with submerge dike of different thickness

    NASA Astrophysics Data System (ADS)

    Zhiltsov, Konstantin; Kostyushin, Kirill; Kagenov, Anuar; Tyryshkin, Ilya

    2017-11-01

    This paper presents a mathematical investigation of the interaction of a long tsunami-type wave with a submerge dike. The calculations were performed by using the freeware package OpenFOAM. Unsteady two-dimensional Navier-Stokes equations were used for mathematical modeling of incompressible two-phase medium. The Volume of Fluid (VOF) method is used to capture the free surface of a liquid. The effects caused by long wave of defined amplitude motion through a submerged dike of varying thickness were discussed in detail. Numerical results show that after wave passing through the barrier, multiple vortex structures were formed behind. Intensity of vortex depended on the size of the barrier. The effectiveness of the submerge barrier was estimated by evaluating the wave reflection and transmission coefficients using the energy integral method. Then, the curves of the dependences of the reflection and transmission coefficients were obtained for the interaction of waves with the dike. Finally, it was confirmed that the energy of the wave could be reduced by more than 50% when it passed through the barrier.

  8. Long-term evaluation of impedance levels and clinical development in subthalamic deep brain stimulation for Parkinson's disease.

    PubMed

    Hartmann, C J; Wojtecki, L; Vesper, J; Volkmann, J; Groiss, S J; Schnitzler, A; Südmeyer, M

    2015-10-01

    This study was conducted to better understand the development of clinical efficacy and impedance levels in the long-term course of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD). In this retrospective study of twenty PD patients, the motor part of the Unified Parkinson's Disease Rating Scale was periodically assessed i) after withdrawal of medication and inactivated stimulation, ii) after withdrawal of medication with activated stimulation and iii) after challenge with l-Dopa during activated stimulation up to 13 years after surgery. STN-DBS with or without medication significantly improved motor function up to 13 years after surgery. The contribution of axial symptoms increased over time. While the stimulation parameters were kept constant, the therapeutic impedances progressively declined. STN-DBS in PD remains effective in the long-term course of the disease. Constant current stimulation might be preferable over voltage-controlled stimulation, as it would alleviate the impact of impedance changes on the volume of tissue activated. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Effect of consecutive alternating administration (CAA) of a triple anti-enteroviral combination on Coxsackievirus B1 neuroinfection in mice.

    PubMed

    Stoyanova, Adelina; Nikolova, Ivanka; Galabov, Angel S

    2015-09-01

    Currently, clinically effective antivirals for use in the treatment of enteroviral (EV) infections do not exist. The main reason is the development of drug resistance, the principle obstacle in the development of EV infection chemotherapy, based til now on monotherapy. The most important achievement of our previous studies was the development of a novel scheme for in vivo application of a triple combination of EV inhibitors with different modes of action against Coxsackievirus B (CVB) infections in mice. It consists of consecutive alternating administration (CAA) of the substances in the combination. Here, we tested the effect of the triple combination pleconaril, guanidine-HCl, and oxoglaucine (PGO) via CAA in newborn mice infected with a neurotropic strain of CVB1 (20 LD50 per mouse). This combination manifested a considerable protective effect with pleconaril doses of 25-200mg/kg: it decreased mortality rate (protection index, PI, between 31.3% and 67.7%) and increased mean survival time (MST) by 4-6days. Pleconaril monotherapy demonstrated activity similar to that of PGO via CAA, as measured by PI values, but MST values were slightly lower. However, it also greatly suppressed growth of infected suckling mice, especially at 200mg/kg. This toxic effect was avoided with CAA of PGO at pleconaril doses of 25-100mg/kg. Pleconaril monotherapy administered every 3days was ineffective. The PGO with CAA treatment course decreased infectious virus content, whereas pleconaril monotherapy did not. Analysis of drug-sensitivity in brain samples from CVB1 infected mice, based on IC50 (50% inhibitory concentration) values from cell culture experiments, showed that the CAA course counteracted the development of drug resistance to pleconaril and oxoglaucine in the triple PGO combination and increased drug sensitivity. In contrast, pleconaril and oxoglaucine monotherapies resulted in drug resistance. This data clearly proves the effectiveness of the proposed novel approach-the CAA

  10. A wave model test bed study for wave energy resource characterization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yang, Zhaoqing; Neary, Vincent S.; Wang, Taiping

    This paper presents a test bed study conducted to evaluate best practices in wave modeling to characterize energy resources. The model test bed off the central Oregon Coast was selected because of the high wave energy and available measured data at the site. Two third-generation spectral wave models, SWAN and WWIII, were evaluated. A four-level nested-grid approach—from global to test bed scale—was employed. Model skills were assessed using a set of model performance metrics based on comparing six simulated wave resource parameters to observations from a wave buoy inside the test bed. Both WWIII and SWAN performed well at themore » test bed site and exhibited similar modeling skills. The ST4 package with WWIII, which represents better physics for wave growth and dissipation, out-performed ST2 physics and improved wave power density and significant wave height predictions. However, ST4 physics tended to overpredict the wave energy period. The newly developed ST6 physics did not improve the overall model skill for predicting the six wave resource parameters. Sensitivity analysis using different wave frequencies and direction resolutions indicated the model results were not sensitive to spectral resolutions at the test bed site, likely due to the absence of complex bathymetric and geometric features.« less

  11. Three-dimensional freak waves and higher-order wave-wave resonances

    NASA Astrophysics Data System (ADS)

    Badulin, S. I.; Ivonin, D. V.; Dulov, V. A.

    2012-04-01

    period October 14 - November 6, 2009 almost continuously. Antenna of 6 resistance wave gauges (a pentagon with one center gauge) is used to gain information on wave directions. Wave conditions vary from perfect still to storms with significant wave heights up to Hs = 1.7 meters and wind speeds 15m/s. Measurements with frequency 10Hz for dominant frequencies 0.1 - 0.2Hz fixed 40 freak wave events (criterium H/Hs > 2) and showed no dependence on Hs definitely. Data processing within frequency quasi-spectra approach and directional spectra reconstructions found pronounced features of essentially three-dimensional anomalous waves. All the events are associated with dramatic widening of instant frequency spectra in the range fp - f5w and stronger directional spreading. On the contrary, the classic Benjamin-Feir modulations show no definite links with the events and can be likely treated as dynamically neutral part of wave field. The apparent contradiction with the recent study (Saprykina, Dulov, Kuznetsov, Smolov, 2010) based on the same data collection can be explained partially by features of data processing. Physical roots of the inconsistency should be detailed in further studies. The work was supported by the Russian government contract 11.G34.31.0035 (signed 25 November 2010), Russian Foundation for Basic Research grant 11-05-01114-a, Ukrainian State Agency of Science, Innovations and Information under Contract M/412-2011 and ONR grant N000141010991. Authors gratefully acknowledge continuing support of these foundations.

  12. Midline Frontal Cortex Low-Frequency Activity Drives Subthalamic Nucleus Oscillations during Conflict

    PubMed Central

    Zavala, Baltazar A.; Tan, Huiling; Little, Simon; Ashkan, Keyoumars; Hariz, Marwan; Foltynie, Thomas; Zrinzo, Ludvic; Zaghloul, Kareem A.

    2014-01-01

    Making the right decision from conflicting information takes time. Recent computational, electrophysiological, and clinical studies have implicated two brain areas as being crucial in assuring sufficient time is taken for decision-making under conditions of conflict: the medial prefrontal cortex and the subthalamic nucleus (STN). Both structures exhibit an elevation of activity at low frequencies (<10 Hz) during conflict that correlates with the amount of time taken to respond. This suggests that the two sites could become functionally coupled during conflict. To establish the nature of this interaction we recorded from deep-brain stimulation electrodes implanted bilaterally in the STN of 13 Parkinson's disease patients while they performed a sensory integration task involving randomly moving dots. By gradually increasing the number of dots moving coherently in one direction, we were able to determine changes in the STN associated with response execution. Furthermore, by occasionally having 10% of the dots move in the opposite direction as the majority, we were able to identify an independent increase in STN theta-delta activity triggered by conflict. Crucially, simultaneous midline frontal electroencephalographic recordings revealed an increase in the theta-delta band coherence between the two structures that was specific to high-conflict trials. Activity over the midline frontal cortex was Granger causal to that in STN. These results establish the cortico-subcortical circuit enabling successful choices to be made under conditions of conflict and provide support for the hypothesis that the brain uses frequency-specific channels of communication to convey behaviorally relevant information. PMID:24849364

  13. Midline frontal cortex low-frequency activity drives subthalamic nucleus oscillations during conflict.

    PubMed

    Zavala, Baltazar A; Tan, Huiling; Little, Simon; Ashkan, Keyoumars; Hariz, Marwan; Foltynie, Thomas; Zrinzo, Ludvic; Zaghloul, Kareem A; Brown, Peter

    2014-05-21

    Making the right decision from conflicting information takes time. Recent computational, electrophysiological, and clinical studies have implicated two brain areas as being crucial in assuring sufficient time is taken for decision-making under conditions of conflict: the medial prefrontal cortex and the subthalamic nucleus (STN). Both structures exhibit an elevation of activity at low frequencies (<10 Hz) during conflict that correlates with the amount of time taken to respond. This suggests that the two sites could become functionally coupled during conflict. To establish the nature of this interaction we recorded from deep-brain stimulation electrodes implanted bilaterally in the STN of 13 Parkinson's disease patients while they performed a sensory integration task involving randomly moving dots. By gradually increasing the number of dots moving coherently in one direction, we were able to determine changes in the STN associated with response execution. Furthermore, by occasionally having 10% of the dots move in the opposite direction as the majority, we were able to identify an independent increase in STN theta-delta activity triggered by conflict. Crucially, simultaneous midline frontal electroencephalographic recordings revealed an increase in the theta-delta band coherence between the two structures that was specific to high-conflict trials. Activity over the midline frontal cortex was Granger causal to that in STN. These results establish the cortico-subcortical circuit enabling successful choices to be made under conditions of conflict and provide support for the hypothesis that the brain uses frequency-specific channels of communication to convey behaviorally relevant information. Copyright © 2014 Zavala et al.

  14. Hyperhidrosis associated with subthalamic deep brain stimulation in Parkinson's disease: Insights into central autonomic functional anatomy.

    PubMed

    Ramirez-Zamora, Adolfo; Smith, Heather; Youn, Youngwon; Durphy, Jennifer; Shin, Damian S; Pilitsis, Julie G

    2016-07-15

    There is limited evidence regarding the precise location and connections of thermoregulatory centers in humans. We present two patients managed with subthalamic nucleus (STN) Deep Brain Stimulation (DBS) for motor fluctuations in PD that developed reproducible hyperhidrosis with high frequency DBS. To describe the clinical features and analyze the location of the electrodes leading to autonomic activation in both patients. We retrospectively assessed the anatomical localization, electrode programming settings and effects of unilateral STN DBS leading to hyperhidrosis. Unilateral stimulation of anterior and medially located contacts within the STN and zona incerta (Zi) caused bilateral, consistent, reproducible, and reversible sweating in our patients. Adequate control of motor symptoms without autonomic side effects was accomplished with alternative programming settings. Stimulation of the medial Zi and medial and anterior STN causes hyperhidrosis in a pattern similar to that described in primates and rats. We speculate that central autonomic fibers originating in the lateral hypothalamic area project laterally to the ventral/medial Zi and then to brainstem nuclei following an medial and posterior trajectory in relationship to STN. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Comparative cognitive effects of bilateral subthalamic stimulation and subcutaneous continuous infusion of apomorphine in Parkinson's disease.

    PubMed

    Alegret, Montse; Valldeoriola, Francesc; Martí, MaJosé; Pilleri, Manuela; Junqué, Carme; Rumià, Jordi; Tolosa, Eduardo

    2004-12-01

    Bilateral subthalamic deep brain stimulation (STN-DBS) and continuous subcutaneous infusion of apomorphine (APM-csi) can provide a comparable improvement on motor function in patients with advanced Parkinson's disease (PD), but the mechanisms by which both therapies exert their effects are different. We analyzed the cognitive effects of APM-csi. We also compared neuropsychological effects induced by STN-DBS and APM-csi in advanced PD to ascertain the neuropsychological aspects relevant in determining the therapeutic procedure that is the most appropriate in a particular patient. We studied 9 patients treated with STN-DBS and 7 patients with APM-csi. Neuropsychological measures included Rey's Auditory-Verbal Learning, Stroop, Trail Making, phonetic verbal fluency, and Judgment of Line Orientation tests. In the APM-csi group, significant changes were not observed in the neuropsychological tests performance. By contrast, in the STN-DBS group, moderate worsening was found in phonetic verbal fluency and Stroop Naming scores that was partially reversible at long-term follow-up and did not have consequences on regular activities. Consequently, these findings could be interpreted as being not relevant in deciding the most suitable treatment in a given patient. 2004 Movement Disorder Society.

  16. Waking and dreaming consciousness: neurobiological and functional considerations.

    PubMed

    Hobson, J A; Friston, K J

    2012-07-01

    This paper presents a theoretical review of rapid eye movement sleep with a special focus on pontine-geniculate-occipital waves and what they might tell us about the functional anatomy of sleep and consciousness. In particular, we review established ideas about the nature and purpose of sleep in terms of protoconsciousness and free energy minimization. By combining these theoretical perspectives, we discover answers to some fundamental questions about sleep: for example, why is homeothermy suspended during sleep? Why is sleep necessary? Why are we not surprised by our dreams? What is the role of synaptic regression in sleep? The imperatives for sleep that emerge also allow us to speculate about the functional role of PGO waves and make some empirical predictions that can, in principle, be tested using recent advances in the modeling of electrophysiological data. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Subthalamic deep brain stimulation modulates conscious perception of sensory function in Parkinson's disease.

    PubMed

    Cury, Rubens G; Galhardoni, Ricardo; Teixeira, Manoel J; Dos Santos Ghilardi, Maria G; Silva, Valquiria; Myczkowski, Martin L; Marcolin, Marco A; Barbosa, Egberto R; Fonoff, Erich T; Ciampi de Andrade, Daniel

    2016-12-01

    Subthalamic deep brain stimulation (STN-DBS) is used to treat refractory motor complications in Parkinson disease (PD), but its effects on nonmotor symptoms remain uncertain. Up to 80% of patients with PD may have pain relief after STN-DBS, but it is unknown whether its analgesic properties are related to potential effects on sensory thresholds or secondary to motor improvement. We have previously reported significant and long-lasting pain relief after DBS, which did not correlate with motor symptomatic control. Here we present secondary data exploring the effects of DBS on sensory thresholds in a controlled way and have explored the relationship between these changes and clinical pain and motor improvement after surgery. Thirty-seven patients were prospectively evaluated before STN-DBS and 12 months after the procedure compared with healthy controls. Compared with baseline, patients with PD showed lower thermal and mechanical detection and higher cold pain thresholds after surgery. There were no changes in heat and mechanical pain thresholds. Compared with baseline values in healthy controls, patients with PD had higher thermal and mechanical detection thresholds, which decreased after surgery toward normalization. These sensory changes had no correlation with motor or clinical pain improvement after surgery. These data confirm the existence of sensory abnormalities in PD and suggest that STN-DBS mainly influenced the detection thresholds rather than painful sensations. However, these changes may depend on the specific effects of DBS on somatosensory loops with no correlation to motor or clinical pain improvement.

  18. Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinson's disease.

    PubMed

    Halpern, Casey H; Rick, Jacqueline H; Danish, Shabbar F; Grossman, Murray; Baltuch, Gordon H

    2009-05-01

    Parkinson's disease (PD) is a neurodegenerative disorder characterized by significant motor dysfunction and various non-motor disturbances, including cognitive alterations. Deep brain stimulation (DBS) is an increasingly utilized therapeutic option for patients with PD that yields remarkable success in alleviating disabling motor symptoms. DBS has additionally been associated with changes in cognition, yet the evidence is not consistent across studies. The following review sought to provide a clearer understanding of the various cognitive sequelae of bilateral subthalamic nucleus (STN) DBS while taking into account corresponding neuroanatomy and potential confounding variables. A literature search was performed using the following inclusion criteria: (1) at least five subjects followed for a mean of at least 3 months after surgery; (2) pre- and postoperative cognitive data using at least one standardized measure; (3) adequate report of study results using means and standard deviations. Two recent meta-analyses found mild post-operative impairments in verbal learning and executive function in patients who underwent DBS surgery. However, studies have revealed improved working memory and psychomotor speed in the 'on' vs 'off' stimulation state. A deficit in language may be a consequence of the surgical procedure. While cognitive decline has been observed in some domains, our review of the data suggests that STN DBS is a worthwhile and safe method to treat PD. (c) 2008 John Wiley & Sons, Ltd.

  19. Alternating verbal fluency performance following bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease.

    PubMed

    Marshall, D F; Strutt, A M; Williams, A E; Simpson, R K; Jankovic, J; York, M K

    2012-12-01

    Despite common occurrences of verbal fluency declines following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) for the treatment of Parkinson's disease (PD), alternating fluency measures using cued and uncued paradigms have not been evaluated. Twenty-three STN-DBS patients were compared with 20 non-surgical PD patients on a comprehensive neuropsychological assessment, including cued and uncued intradimensional (phonemic/phonemic and semantic/semantic) and extradimensional (phonemic/semantic) alternating fluency measures at baseline and 6-month follow-up. STN-DBS patients demonstrated a greater decline on the cued phonemic/phonemic fluency and the uncued phonemic/semantic fluency tasks compared to the PD patients. For STN-DBS patients, verbal learning and information processing speed accounted for a significant proportion of the variance in declines in alternating phonemic/phonemic and phonemic/semantic fluency scores, respectively, whilst only naming was related to uncued phonemic/semantic performance for the PD patients. Both groups were aided by cueing for the extradimensional task at baseline and follow-up, and the PD patients were also aided by cueing for the phonemic/phonemic task on follow-up. These findings suggest that changes in alternating fluency are not related to disease progression alone as STN-DBS patients demonstrated greater declines over time than the PD patients, and this change was related to declines in information processing speed. © 2012 The Author(s) European Journal of Neurology © 2012 EFNS.

  20. Subcortical roles in lexical task processing: Inferences from thalamic and subthalamic event-related potentials.

    PubMed

    Tiedt, Hannes O; Ehlen, Felicitas; Krugel, Lea K; Horn, Andreas; Kühn, Andrea A; Klostermann, Fabian

    2017-01-01

    Subcortical functions for language capacities are poorly defined, but may be investigated in the context of deep brain stimulation. Here, we studied event-related potentials recorded from electrodes in the subthalamic nucleus (STN) and the thalamic ventral intermediate nucleus (VIM) together with surface-EEG. Participants completed a lexical decision task (LDT), which required the differentiation of acoustically presented words from pseudo-words by button press. Target stimuli were preceded by prime-words. In recordings from VIM, a slow potential shift apparent at the lower electrode contacts persisted during target stimulus presentation (equally for words and pseudo-words). In contrast, recordings from STN electrodes showed a short local activation on prime-words but not target-stimuli. In both depth-recording regions, further components related to contralateral motor responses to target words were evident. On scalp level, mid-central activations on (pseudo)lexical stimuli were obtained, in line with the expression of N400 potentials. The prolonged activity recorded from VIM, exclusively accompanying the relevant LDT phase, is in line with the idea of thalamic "selective engagement" for supporting the realization of the behavioral focus demanded by the task. In contrast, the phasic prime related activity rather indicates "procedural" STN functions, for example, for trial sequencing or readiness inhibition of prepared target reactions. Hum Brain Mapp 38:370-383, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  1. Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients.

    PubMed

    Vonberg, Isabelle; Ehlen, Felicitas; Fromm, Ortwin; Kühn, Andrea A; Klostermann, Fabian

    2016-01-01

    Reduced verbal fluency (VF) has been reported in patients with Parkinson's disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modified by STN DBS. Eleven PD patients performed VF tasks in their STN DBS ON and OFF condition. To differentiate VF-components modulated by the stimulation, a temporal cluster analysis was performed, separating production spurts (i.e., 'clusters' as correlates of automatic activation spread within lexical fields) from slower cluster transitions (i.e., 'switches' reflecting set-shifting towards new lexical fields). The results were compared to those of eleven healthy control subjects. PD patients produced significantly more switches accompanied by shorter switch times in the STN DBS ON compared to the STN DBS OFF condition. The number of clusters and time intervals between words within clusters were not affected by the treatment state. Although switch behavior in patients with DBS ON improved, their task performance was still lower compared to that of healthy controls. Beyond impacting on motor symptoms, STN DBS seems to influence the dynamics of cognitive procedures. Specifically, the results are in line with basal ganglia roles for cognitive switching, in the particular case of VF, from prevailing lexical concepts to new ones.

  2. Large-Amplitude Electrostatic Waves Observed at a Supercritical Interplanetary Shock

    NASA Technical Reports Server (NTRS)

    Wilson, L. B., III; Cattell, C. A.; Kellogg, P. J.; Goetz, K.; Kersten, K.; Kasper, J. C.; Szabo, A.; Wilber, M.

    2010-01-01

    We present the first observations at an interplanetary shock of large-amplitude (> 100 mV/m pk-pk) solitary waves and large-amplitude (approx.30 mV/m pk-pk) waves exhibiting characteristics consistent with electron Bernstein waves. The Bernstein-like waves show enhanced power at integer and half-integer harmonics of the cyclotron frequency with a broadened power spectrum at higher frequencies, consistent with the electron cyclotron drift instability. The Bernstein-like waves are obliquely polarized with respect to the magnetic field but parallel to the shock normal direction. Strong particle heating is observed in both the electrons and ions. The observed heating and waveforms are likely due to instabilities driven by the free energy provided by reflected ions at this supercritical interplanetary shock. These results offer new insights into collisionless shock dissipation and wave-particle interactions in the solar wind.

  3. Small Moon Makes Big Waves

    NASA Image and Video Library

    2012-12-31

    Saturn small moon Daphnis is caught in the act of raising waves on the edges of the Keeler gap, which is the thin dark band in the left half of the image. Waves like these allow scientists to locate small moons in gaps and measure their masses.

  4. Impulse control behaviors and subthalamic deep brain stimulation in Parkinson disease.

    PubMed

    Merola, Aristide; Romagnolo, Alberto; Rizzi, Laura; Rizzone, Mario Giorgio; Zibetti, Maurizio; Lanotte, Michele; Mandybur, George; Duker, Andrew P; Espay, Alberto J; Lopiano, Leonardo

    2017-01-01

    To determine the clinical and demographic correlates of persistent, remitting, and new-onset impulse control behaviors (ICBs) before and after subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We compared the pre- and post-surgical prevalence of ICBs, classified as impulse control disorders (ICD), dopamine dysregulation syndrome (DDS), and punding in 150 consecutive PD STN-DBS-treated patients and determined the association with motor, cognitive, neuropsychological, and neuropsychiatric endpoints. At baseline (before STN-DBS), ICBs were associated with younger age (p = 0.045) and male gender (85 %; p = 0.001). Over an average follow-up of 4.3 ± 2.1 years of chronic STN-DBS there was an overall trend for reduction in ICBs (from 17.3 to 12.7 %; p = 0.095) with significant improvement in hypersexuality (12-8.0 %; p = 0.047), gambling (10.7-5.3 %; p = 0.033), and DDS (4.7-0 %; p < 0.001). ICB remitted in 18/26 patients (69 %) and persisted in 8/26 (31 %); the latter group was characterized by higher levodopa equivalent daily dose. Patients who developed a new-onset ICB during follow-up (n = 11/150) were characterized by younger age (p = 0.042), lower dyskinesia improvement (p ≤ 0.035), and a gender distribution with higher prevalence of women (p = 0.018). In addition, new-onset ICB was more common among patients with borderline, schizoid, and/or schizotypal traits of personality disorders; persistent ICB in those with obsessive-compulsive traits. PD-related ICBs exhibit a complex outcome after STN-DBS, with a tendency for overall reduction but with age, gender, dopaminergic therapy, and neuropsychiatric features exerting independent effects.

  5. Dopamine-dependent non-linear correlation between subthalamic rhythms in Parkinson's disease.

    PubMed

    Marceglia, S; Foffani, G; Bianchi, A M; Baselli, G; Tamma, F; Egidi, M; Priori, A

    2006-03-15

    The basic information architecture in the basal ganglia circuit is under debate. Whereas anatomical studies quantify extensive convergence/divergence patterns in the circuit, suggesting an information sharing scheme, neurophysiological studies report an absence of linear correlation between single neurones in normal animals, suggesting a segregated parallel processing scheme. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys and in parkinsonian patients single neurones become linearly correlated, thus leading to a loss of segregation between neurones. Here we propose a possible integrative solution to this debate, by extending the concept of functional segregation from the cellular level to the network level. To this end, we recorded local field potentials (LFPs) from electrodes implanted for deep brain stimulation (DBS) in the subthalamic nucleus (STN) of parkinsonian patients. By applying bispectral analysis, we found that in the absence of dopamine stimulation STN LFP rhythms became non-linearly correlated, thus leading to a loss of segregation between rhythms. Non-linear correlation was particularly consistent between the low-beta rhythm (13-20 Hz) and the high-beta rhythm (20-35 Hz). Levodopa administration significantly decreased these non-linear correlations, therefore increasing segregation between rhythms. These results suggest that the extensive convergence/divergence in the basal ganglia circuit is physiologically necessary to sustain LFP rhythms distributed in large ensembles of neurones, but is not sufficient to induce correlated firing between neurone pairs. Conversely, loss of dopamine generates pathological linear correlation between neurone pairs, alters the patterns within LFP rhythms, and induces non-linear correlation between LFP rhythms operating at different frequencies. The pathophysiology of information processing in the human basal ganglia therefore involves not only activities of individual rhythms, but also

  6. Dopamine-dependent non-linear correlation between subthalamic rhythms in Parkinson's disease

    PubMed Central

    Marceglia, S; Foffani, G; Bianchi, A M; Baselli, G; Tamma, F; Egidi, M; Priori, A

    2006-01-01

    The basic information architecture in the basal ganglia circuit is under debate. Whereas anatomical studies quantify extensive convergence/divergence patterns in the circuit, suggesting an information sharing scheme, neurophysiological studies report an absence of linear correlation between single neurones in normal animals, suggesting a segregated parallel processing scheme. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys and in parkinsonian patients single neurones become linearly correlated, thus leading to a loss of segregation between neurones. Here we propose a possible integrative solution to this debate, by extending the concept of functional segregation from the cellular level to the network level. To this end, we recorded local field potentials (LFPs) from electrodes implanted for deep brain stimulation (DBS) in the subthalamic nucleus (STN) of parkinsonian patients. By applying bispectral analysis, we found that in the absence of dopamine stimulation STN LFP rhythms became non-linearly correlated, thus leading to a loss of segregation between rhythms. Non-linear correlation was particularly consistent between the low-beta rhythm (13–20 Hz) and the high-beta rhythm (20–35 Hz). Levodopa administration significantly decreased these non-linear correlations, therefore increasing segregation between rhythms. These results suggest that the extensive convergence/divergence in the basal ganglia circuit is physiologically necessary to sustain LFP rhythms distributed in large ensembles of neurones, but is not sufficient to induce correlated firing between neurone pairs. Conversely, loss of dopamine generates pathological linear correlation between neurone pairs, alters the patterns within LFP rhythms, and induces non-linear correlation between LFP rhythms operating at different frequencies. The pathophysiology of information processing in the human basal ganglia therefore involves not only activities of individual rhythms, but also

  7. Asymmetric right/left encoding of emotions in the human subthalamic nucleus

    PubMed Central

    Eitan, Renana; Shamir, Reuben R.; Linetsky, Eduard; Rosenbluh, Ovadya; Moshel, Shay; Ben-Hur, Tamir; Bergman, Hagai; Israel, Zvi

    2013-01-01

    Emotional processing is lateralized to the non-dominant brain hemisphere. However, there is no clear spatial model for lateralization of emotional domains in the basal ganglia. The subthalamic nucleus (STN), an input structure in the basal ganglia network, plays a major role in the pathophysiology of Parkinson's disease (PD). This role is probably not limited only to the motor deficits of PD, but may also span the emotional and cognitive deficits commonly observed in PD patients. Beta oscillations (12–30 Hz), the electrophysiological signature of PD, are restricted to the dorsolateral part of the STN that corresponds to the anatomically defined sensorimotor STN. The more medial, more anterior and more ventral parts of the STN are thought to correspond to the anatomically defined limbic and associative territories of the STN. Surprisingly, little is known about the electrophysiological properties of the non-motor domains of the STN, nor about electrophysiological differences between right and left STNs. In this study, microelectrodes were utilized to record the STN spontaneous spiking activity and responses to vocal non-verbal emotional stimuli during deep brain stimulation (DBS) surgeries in human PD patients. The oscillation properties of the STN neurons were used to map the dorsal oscillatory and the ventral non-oscillatory regions of the STN. Emotive auditory stimulation evoked activity in the ventral non-oscillatory region of the right STN. These responses were not observed in the left ventral STN or in the dorsal regions of either the right or left STN. Therefore, our results suggest that the ventral non-oscillatory regions are asymmetrically associated with non-motor functions, with the right ventral STN associated with emotional processing. These results suggest that DBS of the right ventral STN may be associated with beneficial or adverse emotional effects observed in PD patients and may relieve mental symptoms in other neurological and psychiatric

  8. Pseudo-incompressible, finite-amplitude gravity waves: wave trains and stability

    NASA Astrophysics Data System (ADS)

    Schlutow, Mark; Klein, Rupert

    2017-04-01

    Based on weak asymptotic WKB-like solutions for two-dimensional atmospheric gravity waves (GWs) traveling wave solutions (wave trains) are derived and analyzed with respect to stability. A systematic multiple-scale analysis using the ratio of the dominant wavelength and the scale height as a scale separation parameter is applied on the fully compressible Euler equations. A distinguished limit favorable for GWs close to static instability, reveals that pseudo-incompressible rather than Boussinesq theory applies. A spectral expansion including a mean flow, combined with the additional WKB assumption of slowly varying phases and amplitudes, is used to find general weak asymptotic solutions. This ansatz allows for arbitrarily strong, non-uniform stratification and holds even for finite-amplitude waves. It is deduced that wave trains as leading order solutions can only exist if either some non-uniform background stratification is given but the wave train propagates only horizontally or if the wave train velocity vector is given but the background is isothermal. For the first case, general analytical solutions are obtained that may be used to model mountain lee waves. For the second case with the additional assumption of horizontal periodicity, upward propagating wave train fronts were found. These wave train fronts modify the mean flow beyond the non-acceleration theorem. Stability analysis reveal that they are intrinsically modulationally unstable. The range of validity for the scale separation parameter was tested with fully nonlinear simulations. Even for large values an excellent agreement with the theory was found.

  9. Dispersionless wave packets in Dirac materials

    NASA Astrophysics Data System (ADS)

    Jakubský, Vít; Tušek, Matěj

    2017-03-01

    We show that a wide class of quantum systems with translational invariance can host dispersionless, soliton-like, wave packets. We focus on the setting where the effective, two-dimensional Hamiltonian acquires the form of the Dirac operator. The proposed framework for construction of the dispersionless wave packets is illustrated on silicene-like systems with topologically nontrivial effective mass. Our analytical predictions are accompanied by a numerical analysis and possible experimental realizations are discussed.

  10. Experimental Investigation of Irregular Wave Cancellation Using a Cycloidal Wave Energy Converter

    DTIC Science & Technology

    2012-07-01

    83388 EXPERIMENTAL INVESTIGATION OF IRREGULAR WAVE CANCELLATION USING A CYCLOIDAL WAVE ENERGY CONVERTER Stefan G. Siegel∗ Department of Aeronautics...United States Air Force Academy Air Force Academy, Colorado, 80840 USA Email: stefan @siegels.us Casey Fagley Department of Aeronautics United States Air...would like to acknowledge fruitful discussion with Dr. Jürgen Seidel and Dr. Tiger Jeans. This material is based upon activities supported by the

  11. Wind Observations of Wave Heating and/or Particle Energization at Supercritical Interplanetary Shocks

    NASA Technical Reports Server (NTRS)

    Wilson, Lynn Bruce, III; Szabo, Adam; Koval, Andriy; Cattell, Cynthia A.; Kellogg, Paul J.; Goetz, Keith; Breneman, Aaron; Kersten, Kris; Kasper, Justin C.; Pulupa, Marc

    2011-01-01

    We present the first observations at supercritical interplanetary shocks of large amplitude (> 100 mV/m pk-pk) solitary waves, approx.30 mV/m pk-pk waves exhibiting characteristics consistent with electron Bernstein waves, and > 20 nT pk-pk electromagnetic lower hybrid-like waves, with simultaneous evidence for wave heating and particle energization. The solitary waves and the Bernstein-like waves were likely due to instabilities driven by the free energy provided by reflected ions [Wilson III et al., 2010]. They were associated with strong particle heating in both the electrons and ions. We also show a case example of parallel electron energization and perpendicular ion heating due to a electromagnetic lower hybrid-like wave. Both studies provide the first experimental evidence of wave heating and/or particle energization at interplanetary shocks. Our experimental results, together with the results of recent Vlasov [Petkaki and Freeman, 2008] and PIC [Matsukyo and Scholer, 2006] simulations using realistic mass ratios provide new evidence to suggest that the importance of wave-particle dissipation at shocks may be greater than previously thought.

  12. Nonlinear modeling of wave-topography interactions, shear instabilities and shear induced wave breaking using vortex method

    NASA Astrophysics Data System (ADS)

    Guha, Anirban

    2017-11-01

    Theoretical studies on linear shear instabilities as well as different kinds of wave interactions often use simple velocity and/or density profiles (e.g. constant, piecewise) for obtaining good qualitative and quantitative predictions of the initial disturbances. Moreover, such simple profiles provide a minimal model to obtain a mechanistic understanding of shear instabilities. Here we have extended this minimal paradigm into nonlinear domain using vortex method. Making use of unsteady Bernoulli's equation in presence of linear shear, and extending Birkhoff-Rott equation to multiple interfaces, we have numerically simulated the interaction between multiple fully nonlinear waves. This methodology is quite general, and has allowed us to simulate diverse problems that can be essentially reduced to the minimal system with interacting waves, e.g. spilling and plunging breakers, stratified shear instabilities (Holmboe, Taylor-Caulfield, stratified Rayleigh), jet flows, and even wave-topography interaction problem like Bragg resonance. We found that the minimal models capture key nonlinear features (e.g. wave breaking features like cusp formation and roll-ups) which are observed in experiments and/or extensive simulations with smooth, realistic profiles.

  13. A Guided Wave Sensor Enabling Simultaneous Wavenumber-Frequency Analysis for Both Lamb and Shear-Horizontal Waves.

    PubMed

    Ren, Baiyang; Cho, Hwanjeong; Lissenden, Cliff J

    2017-03-01

    Guided waves in plate-like structures have been widely investigated for structural health monitoring. Lamb waves and shear horizontal (SH) waves, two commonly used types of waves in plates, provide different benefits for the detection of various types of defects and material degradation. However, there are few sensors that can detect both Lamb and SH waves and also resolve their modal content, namely the wavenumber-frequency spectrum. A sensor that can detect both waves is desirable to take full advantage of both types of waves in order to improve sensitivity to different discontinuity geometries. We demonstrate that polyvinylidene difluoride (PVDF) film provides the basis for a multi-element array sensor that detects both Lamb and SH waves and also measures their modal content, i.e., the wavenumber-frequency spectrum.

  14. Pilot-Wave Hydrodynamics

    NASA Astrophysics Data System (ADS)

    Bush, John W. M.

    2015-01-01

    Yves Couder, Emmanuel Fort, and coworkers recently discovered that a millimetric droplet sustained on the surface of a vibrating fluid bath may self-propel through a resonant interaction with its own wave field. This article reviews experimental evidence indicating that the walking droplets exhibit certain features previously thought to be exclusive to the microscopic, quantum realm. It then reviews theoretical descriptions of this hydrodynamic pilot-wave system that yield insight into the origins of its quantum-like behavior. Quantization arises from the dynamic constraint imposed on the droplet by its pilot-wave field, and multimodal statistics appear to be a feature of chaotic pilot-wave dynamics. I attempt to assess the potential and limitations of this hydrodynamic system as a quantum analog. This fluid system is compared to quantum pilot-wave theories, shown to be markedly different from Bohmian mechanics and more closely related to de Broglie's original conception of quantum dynamics, his double-solution theory, and its relatively recent extensions through researchers in stochastic electrodynamics.

  15. Science 101: Can Electromagnetic Waves Affect Emotions?

    ERIC Educational Resources Information Center

    Robertson, Bill

    2017-01-01

    The answer to this month's question, "Can electromagnetic waves affect emotions," is yes. Wherever there are electromagnetic (EM) waves (basically everywhere!), there is the potential for them directly or indirectly to affect the emotions. But what about the likely motivation behind the originally-posed question? Can EM waves affect your…

  16. On Multiple Hall-Like Electron Currents and Tripolar Guide Magnetic Field Perturbations During Kelvin-Helmholtz Waves

    NASA Astrophysics Data System (ADS)

    Sturner, Andrew P.; Eriksson, Stefan; Nakamura, Takuma; Gershman, Daniel J.; Plaschke, Ferdinand; Ergun, Robert E.; Wilder, Frederick D.; Giles, Barbara; Pollock, Craig; Paterson, William R.; Strangeway, Robert J.; Baumjohann, Wolfgang; Burch, James L.

    2018-02-01

    Two magnetopause current sheet crossings with tripolar guide magnetic field signatures were observed by multiple Magnetosphere Multiscale (MMS) spacecraft during Kelvin-Helmholtz wave activity. The two out-of-plane magnetic field depressions of the tripolar guide magnetic field are largely supported by the observed in-plane electron currents, which are reminiscent of two clockwise Hall current loop systems. A comparison with a three-dimensional kinetic simulation of Kelvin-Helmholtz waves and vortex-induced reconnection suggests that MMS likely encountered the two Hall magnetic field depressions on either side of a magnetic reconnection X-line. Moreover, MMS observed an out-of-plane current reversal and a corresponding in-plane magnetic field rotation at the center of one of the current sheets, suggesting the presence of two adjacent flux ropes. The region inside one of the ion-scale flux ropes was characterized by an observed decrease of the total magnetic field, a strong axial current, and significant enhancements of electron density and parallel electron temperature. The flux rope boundary was characterized by currents opposite this axial current, strong in-plane and converging electric fields, parallel electric fields, and weak electron-frame Joule dissipation. These return current region observations may reflect a need to support the axial current rather than representing local reconnection signatures in the absence of any exhausts.

  17. Articulation Features of Parkinson's Disease Patients with Subthalamic Nucleus Deep Brain Stimulation.

    PubMed

    Tanaka, Yasuhiro; Tsuboi, Takashi; Watanabe, Hirohisa; Kajita, Yasukazu; Nakatsubo, Daisuke; Fujimoto, Yasushi; Ohdake, Reiko; Ito, Mizuki; Atsuta, Naoki; Yamamoto, Masahiko; Wakabayashi, Toshihiko; Katsuno, Masahisa; Sobue, Gen

    2016-10-19

    Voice and speech disorders are one of the most important issues after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients. However, articulation features in this patient population remain unclear. We studied the articulation features of PD patients with STN-DBS. Participants were 56 PD patients treated with STN-DBS (STN-DBS group) and 41 patients treated only with medical therapy (medical-therapy-alone group). Articulation function was evaluated with acoustic and auditory-perceptual analyses. The vowel space area (VSA) was calculated using the formant frequency data of three vowels (/a/, /i/, and /u/) from sustained phonation task. The VSA reportedly reflects the distance of mouth/jaw and tongue movements during speech and phonation. Correlations between acoustic and auditory-perceptual measurements were also assessed. The VSA did not significantly differ between the medical-therapy-alone group and the STN-DBS group in the off-stimulation condition. In the STN-DBS group, the VSA was larger in the on-stimulation condition than in the off-stimulation condition. However, individual analysis showed the VSA changes after stopping stimulation were heterogeneous. In total, 89.8% of the STN-DBS group showed a large VSA size in the on- than in the off-stimulation condition. In contrast, the VSA of the remaining patients in that group was smaller in the on- than the off-stimulation condition. STN-DBS may resolve hypokinesia of the articulation structures, including the mouth/jaw and tongue, and improve maximal vowel articulation. However, in the on-stimulation condition, the VSA was not significantly correlated with speech intelligibility. This may be because STN-DBS potentially affects other speech processes such as voice and/or respiratory process.

  18. Modulation of the subthalamic nucleus activity by serotonergic agents and fluoxetine administration.

    PubMed

    Aristieta, A; Morera-Herreras, T; Ruiz-Ortega, J A; Miguelez, C; Vidaurrazaga, I; Arrue, A; Zumarraga, M; Ugedo, L

    2014-05-01

    Within the basal ganglia, the subthalamic nucleus (STN) is the only glutamatergic structure and occupies a central position in the indirect pathway. In rat, the STN receives serotonergic input from the dorsal raphe nucleus and expresses serotonergic receptors. This study examined the consequences of serotonergic neurotransmission modulation on STN neuron activity. In vivo single-unit extracellular recordings, HPLC determination, and rotarod and bar test were performed in control, 4-chloro-DL-phenylalanine methyl ester hydrochloride- (pCPA, a serotonin synthesis inhibitor) and chronically fluoxetine-treated rats. The pCPA treatment and the administration of serotonin (5-HT) receptor antagonists increased number of bursting neurons in the STN. The systemic administration of the 5-HT(1A) agonist, 8-OH-DPAT, decreased the firing rate and increased the coefficient of variation of STN neurons in pCPA-treated rats but not in control animals. Additionally, microinjection of 8-OH-DPAT into the STN reduced the firing rate of STN neurons, while microinjection of the 5-HT(2C) agonist, Ro 60-0175, increased the firing rate in both control and fluoxetine-treated animals. Finally, the fluoxetine challenge increased the firing rate of STN neurons in fluoxetine-treated rats and induced catalepsy. Our results indicate that the depletion and the blockage of 5-HT modify STN neuron firing pattern. STN neuron activity is under the control of 5-HT(1A) and 5-HT(2C) receptors located both inside and outside the STN. Finally, fluoxetine increases STN neuron activity in chronically fluoxetine-treated rats, which may explain the role of this nucleus in fluoxetine-induced extrapyramidal side effects.

  19. Parkinsonian Rest Tremor Is Associated With Modulations of Subthalamic High-Frequency Oscillations.

    PubMed

    Hirschmann, Jan; Butz, Markus; Hartmann, Christian J; Hoogenboom, Nienke; Özkurt, Tolga E; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons

    2016-10-01

    High frequency oscillations (>200 Hz) have been observed in the basal ganglia of PD patients and were shown to be modulated by the administration of levodopa and voluntary movement. The objective of this study was to test whether the power of high-frequency oscillations in the STN is associated with spontaneous manifestation of parkinsonian rest tremor. The electromyogram of both forearms and local field potentials from the STN were recorded in 11 PD patients (10 men, age 58 [9.4] years, disease duration 9.2 [6.3] years). Patients were recorded at rest and while performing repetitive hand movements before and after levodopa intake. High-frequency oscillation power was compared across epochs containing rest tremor, tremor-free rest, or voluntary movement and related to the tremor cycle. We observed prominent slow (200-300 Hz) and fast (300-400 Hz) high-frequency oscillations. The ratio between slow and fast high-frequency oscillation power increased when tremor became manifest. This increase was consistent across nuclei (94%) and occurred in medication ON and OFF. The ratio outperformed other potential markers of tremor, such as power at individual tremor frequency, beta power, or low gamma power. For voluntary movement, we did not observe a significant difference when compared with rest or rest tremor. Finally, rhythmic modulations of high-frequency oscillation power occurred within the tremor cycle. Subthalamic high-frequency oscillation power is closely linked to the occurrence of parkinsonian rest tremor. The balance between slow and fast high-frequency oscillation power combines information on motor and medication state. © 2016 International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder Society.

  20. A honeycomb-like three-dimensional metamaterial absorber via super-wideband and wide-angle performances at millimeter wave and low THz frequencies

    NASA Astrophysics Data System (ADS)

    Vahidi, Alireza; Rajabalipanah, Hamid; Abdolali, Ali; Cheldavi, Ahmad

    2018-04-01

    Achieving wideband absorption via three-dimensional (3D) metamaterials has revealed as a new emerging innovative field of research, especially in recent years. Here, a novel 3D metamaterial absorber (MA) having a sixfold symmetry is designed which consists of periodic resistive honeycomb-like units. The proposed 3D MA exhibits a strong absorptivity above 90% in the widest bandwidth ever reported to the authors' knowledge from 50 to 460 GHz (the bandwidth ratio larger than 1:9), covering both millimeter wave and low -terahertz spectra. To understand the physical mechanism of absorption, the electric field and surface current distributions, the power loss density as well as the deteriorating effects of the high-order Floquet modes are monitored and discussed. As a distinctive feature in comparison to the similar 3D MAs, our engineered absorber provides multiple resonances, contributing to further broadening of the operating bandwidth. In addition, it is shown that the honeycomb-like MA retains its polarization-insensitive absorption in a wide range of incident wave angles and polarization angles. Due to flexibility of the design, these superior performances can be simply extended to terahertz, infrared and visible frequencies, potentially leading to many promising applications in imaging, sensing, and camouflage technology.

  1. Calculating wave-generated bottom orbital velocities from surface-wave parameters

    USGS Publications Warehouse

    Wiberg, P.L.; Sherwood, C.R.

    2008-01-01

    Near-bed wave orbital velocities and shear stresses are important parameters in many sediment-transport and hydrodynamic models of the coastal ocean, estuaries, and lakes. Simple methods for estimating bottom orbital velocities from surface-wave statistics such as significant wave height and peak period often are inaccurate except in very shallow water. This paper briefly reviews approaches for estimating wave-generated bottom orbital velocities from near-bed velocity data, surface-wave spectra, and surface-wave parameters; MATLAB code for each approach is provided. Aspects of this problem have been discussed elsewhere. We add to this work by providing a method for using a general form of the parametric surface-wave spectrum to estimate bottom orbital velocity from significant wave height and peak period, investigating effects of spectral shape on bottom orbital velocity, comparing methods for calculating bottom orbital velocity against values determined from near-bed velocity measurements at two sites on the US east and west coasts, and considering the optimal representation of bottom orbital velocity for calculations of near-bed processes. Bottom orbital velocities calculated using near-bed velocity data, measured wave spectra, and parametric spectra for a site on the northern California shelf and one in the mid-Atlantic Bight compare quite well and are relatively insensitive to spectral shape except when bimodal waves are present with maximum energy at the higher-frequency peak. These conditions, which are most likely to occur at times when bottom orbital velocities are small, can be identified with our method as cases where the measured wave statistics are inconsistent with Donelan's modified form of the Joint North Sea Wave Project (JONSWAP) spectrum. We define the 'effective' forcing for wave-driven, near-bed processes as the product of the magnitude of forcing times its probability of occurrence, and conclude that different bottom orbital velocity statistics

  2. On the interaction of small-scale linear waves with nonlinear solitary waves

    NASA Astrophysics Data System (ADS)

    Xu, Chengzhu; Stastna, Marek

    2017-04-01

    In the study of environmental and geophysical fluid flows, linear wave theory is well developed and its application has been considered for phenomena of various length and time scales. However, due to the nonlinear nature of fluid flows, in many cases results predicted by linear theory do not agree with observations. One of such cases is internal wave dynamics. While small-amplitude wave motion may be approximated by linear theory, large amplitude waves tend to be solitary-like. In some cases, when the wave is highly nonlinear, even weakly nonlinear theories fail to predict the wave properties correctly. We study the interaction of small-scale linear waves with nonlinear solitary waves using highly accurate pseudo spectral simulations that begin with a fully nonlinear solitary wave and a train of small-amplitude waves initialized from linear waves. The solitary wave then interacts with the linear waves through either an overtaking collision or a head-on collision. During the collision, there is a net energy transfer from the linear wave train to the solitary wave, resulting in an increase in the kinetic energy carried by the solitary wave and a phase shift of the solitary wave with respect to a freely propagating solitary wave. At the same time the linear waves are greatly reduced in amplitude. The percentage of energy transferred depends primarily on the wavelength of the linear waves. We found that after one full collision cycle, the longest waves may retain as much as 90% of the kinetic energy they had initially, while the shortest waves lose almost all of their initial energy. We also found that a head-on collision is more efficient in destroying the linear waves than an overtaking collision. On the other hand, the initial amplitude of the linear waves has very little impact on the percentage of energy that can be transferred to the solitary wave. Because of the nonlinearity of the solitary wave, these results provide us some insight into wave-mean flow

  3. Segregation of helicity in inertial wave packets

    NASA Astrophysics Data System (ADS)

    Ranjan, A.

    2017-03-01

    Inertial waves are known to exist in the Earth's rapidly rotating outer core and could be important for the dynamo generation. It is well known that a monochromatic inertial plane wave traveling parallel to the rotation axis (along positive z ) has negative helicity while the wave traveling antiparallel (negative z ) has positive helicity. Such a helicity segregation, north and south of the equator, is necessary for the α2-dynamo model based on inertial waves [Davidson, Geophys. J. Int. 198, 1832 (2014), 10.1093/gji/ggu220] to work. The core is likely to contain a myriad of inertial waves of different wave numbers and frequencies. In this study, we investigate whether this characteristic of helicity segregation also holds for an inertial wave packet comprising waves with the same sign of Cg ,z, the z component of group velocity. We first derive the polarization relations for inertial waves and subsequently derive the resultant helicity in wave packets forming as a result of superposition of two or more waves. We find that the helicity segregation does hold for an inertial wave packet unless the wave numbers of the constituent waves are widely separated. In the latter case, regions of opposite color helicity do appear, but the mean helicity retains the expected sign. An illustration of this observation is provided by (a) calculating the resultant helicity for a wave packet formed by superposition of four upward-propagating inertial waves with different wave vectors and (b) conducting the direct numerical simulation of a Gaussian eddy under rapid rotation. Last, the possible effects of other forces such as the viscous dissipation, the Lorentz force, buoyancy stratification, and nonlinearity on helicity are investigated and discussed. The helical structure of the wave packet is likely to remain unaffected by dissipation or the magnetic field, but can be modified by the presence of linearly stable stratification and nonlinearity.

  4. A guided wave sensor enabling simultaneous wavenumber-frequency analysis for both lamb and shear-horizontal waves

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ren, Baiyang; Cho, Hwanjeong; Lissenden, Cliff J.

    Guided waves in plate-like structures have been widely investigated for structural health monitoring. Lamb waves and shear horizontal (SH) waves, two commonly used types of waves in plates, provide different benefits for the detection of various types of defects and material degradation. However, there are few sensors that can detect both Lamb and SH waves and also resolve their modal content, namely the wavenumber-frequency spectrum. A sensor that can detect both waves is desirable to take full advantage of both types of waves in order to improve sensitivity to different discontinuity geometries. As a result, we demonstrate that polyvinylidene difluoridemore » (PVDF) film provides the basis for a multi-element array sensor that detects both Lamb and SH waves and also measures their modal content, i.e., the wavenumber-frequency spectrum.« less

  5. A guided wave sensor enabling simultaneous wavenumber-frequency analysis for both lamb and shear-horizontal waves

    DOE PAGES

    Ren, Baiyang; Cho, Hwanjeong; Lissenden, Cliff J.

    2017-03-01

    Guided waves in plate-like structures have been widely investigated for structural health monitoring. Lamb waves and shear horizontal (SH) waves, two commonly used types of waves in plates, provide different benefits for the detection of various types of defects and material degradation. However, there are few sensors that can detect both Lamb and SH waves and also resolve their modal content, namely the wavenumber-frequency spectrum. A sensor that can detect both waves is desirable to take full advantage of both types of waves in order to improve sensitivity to different discontinuity geometries. As a result, we demonstrate that polyvinylidene difluoridemore » (PVDF) film provides the basis for a multi-element array sensor that detects both Lamb and SH waves and also measures their modal content, i.e., the wavenumber-frequency spectrum.« less

  6. NWTC Researchers Develop Wave Energy Conversion Technology | News | NREL

    Science.gov Websites

    capturing the energy of waves. But therein is the problem. "It's not like a wind farm where you can like buoys that move up and down in the water. The simplest type is a device that, as the waves hit engineering to control systems. "We thought to add something like a pitch control on a wind turbine."

  7. Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus.

    PubMed

    Atherton, Jeremy F; Wokosin, David L; Ramanathan, Sankari; Bevan, Mark D

    2008-12-01

    The activity of the subthalamic nucleus (STN) is intimately related to movement and is generated, in part, by voltage-dependent Na(+) (Na(v)) channels that drive autonomous firing. In order to determine the principles underlying the initiation and propagation of action potentials in STN neurons, 2-photon laser scanning microscopy was used to guide tight-seal whole-cell somatic and loose-seal cell-attached axonal/dendritic patch-clamp recordings and compartment-selective ion channel manipulation in rat brain slices. Action potentials were first detected in a region that corresponded most closely to the unmyelinated axon initial segment, as defined by Golgi and ankyrin G labelling. Following initiation, action potentials propagated reliably into axonal and somatodendritic compartments with conduction velocities of approximately 5 m s(-1) and approximately 0.7 m s(-1), respectively. Action potentials generated by neurons with axons truncated within or beyond the axon initial segment were not significantly different. However, axon initial segment and somatic but not dendritic or more distal axonal application of low [Na(+)] ACSF or the selective Na(v) channel blocker tetrodotoxin consistently depolarized action potential threshold. Finally, somatodendritic but not axonal application of GABA evoked large, rapid inhibitory currents in concordance with electron microscopic analyses, which revealed that the somatodendritic compartment was the principal target of putative inhibitory inputs. Together the data are consistent with the conclusions that in STN neurons the axon initial segment and soma express an excess of Na(v) channels for the generation of autonomous activity, while synaptic activation of somatodendritic GABA(A) receptors regulates the axonal initiation of action potentials.

  8. Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus

    PubMed Central

    Atherton, Jeremy F; Wokosin, David L; Ramanathan, Sankari; Bevan, Mark D

    2008-01-01

    The activity of the subthalamic nucleus (STN) is intimately related to movement and is generated, in part, by voltage-dependent Na+ (Nav) channels that drive autonomous firing. In order to determine the principles underlying the initiation and propagation of action potentials in STN neurons, 2-photon laser scanning microscopy was used to guide tight-seal whole-cell somatic and loose-seal cell-attached axonal/dendritic patch-clamp recordings and compartment-selective ion channel manipulation in rat brain slices. Action potentials were first detected in a region that corresponded most closely to the unmyelinated axon initial segment, as defined by Golgi and ankyrin G labelling. Following initiation, action potentials propagated reliably into axonal and somatodendritic compartments with conduction velocities of ∼5 m s−1 and ∼0.7 m s−1, respectively. Action potentials generated by neurons with axons truncated within or beyond the axon initial segment were not significantly different. However, axon initial segment and somatic but not dendritic or more distal axonal application of low [Na+] ACSF or the selective Nav channel blocker tetrodotoxin consistently depolarized action potential threshold. Finally, somatodendritic but not axonal application of GABA evoked large, rapid inhibitory currents in concordance with electron microscopic analyses, which revealed that the somatodendritic compartment was the principal target of putative inhibitory inputs. Together the data are consistent with the conclusions that in STN neurons the axon initial segment and soma express an excess of Nav channels for the generation of autonomous activity, while synaptic activation of somatodendritic GABAA receptors regulates the axonal initiation of action potentials. PMID:18832425

  9. Influence of subthalamic deep-brain stimulation on cognitive action control in incentive context.

    PubMed

    Houvenaghel, Jean-François; Duprez, Joan; Argaud, Soizic; Naudet, Florian; Dondaine, Thibaut; Robert, Gabriel Hadrien; Drapier, Sophie; Haegelen, Claire; Jannin, Pierre; Drapier, Dominique; Vérin, Marc; Sauleau, Paul

    2016-10-01

    Subthalamic nucleus deep-brain stimulation (STN-DBS) is an effective treatment in Parkinson's disease (PD), but can have cognitive side effects, such as increasing the difficulty of producing appropriate responses when a habitual but inappropriate responses represent strong alternatives. STN-DBS also appears to modulate representations of incentives such as monetary rewards. Furthermore, conflict resolution can be modulated by incentive context. We therefore used a rewarded Simon Task to assess the influence of promised rewards on cognitive action control in 50 patients with PD, half of whom were being treated with STN-DBS. Results were analyzed according to the activation-suppression model. We showed that STN-DBS (i) favored the expression of motor impulsivity, as measured with the Barratt Impulsiveness Scale, (ii) facilitated the expression of incentive actions as observed with a greater increase in speed according to promised reward in patients with versus without DBS and (iii) may increase impulsive action selection in an incentive context. In addition, analysis of subgroups of implanted patients suggested that those who exhibited the most impulsive action selection had the least severe disease. This may indicate that patients with less marked disease are more at risk of developing impulsivity postoperatively. Finally, in these patients, incentive context increased the difficulty of resolving conflict situations. As a whole, the current study revealed that in patients with PD, STN-DBS affects the cognitive processes involved in conflict resolution, reward processing and the influence of promised rewards on conflict resolution. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Human Subthalamic Nucleus in Movement Error Detection and Its Evaluation during Visuomotor Adaptation

    PubMed Central

    Zavala, Baltazar; Pogosyan, Alek; Ashkan, Keyoumars; Zrinzo, Ludvic; Foltynie, Thomas; Limousin, Patricia; Brown, Peter

    2014-01-01

    Monitoring and evaluating movement errors to guide subsequent movements is a critical feature of normal motor control. Previously, we showed that the postmovement increase in electroencephalographic (EEG) beta power over the sensorimotor cortex reflects neural processes that evaluate motor errors consistent with Bayesian inference (Tan et al., 2014). Whether such neural processes are limited to this cortical region or involve the basal ganglia is unclear. Here, we recorded EEG over the cortex and local field potential (LFP) activity in the subthalamic nucleus (STN) from electrodes implanted in patients with Parkinson's disease, while they moved a joystick-controlled cursor to visual targets displayed on a computer screen. After movement offsets, we found increased beta activity in both local STN LFP and sensorimotor cortical EEG and in the coupling between the two, which was affected by both error magnitude and its contextual saliency. The postmovement increase in the coupling between STN and cortex was dominated by information flow from sensorimotor cortex to STN. However, an information drive appeared from STN to sensorimotor cortex in the first phase of the adaptation, when a constant rotation was applied between joystick inputs and cursor outputs. The strength of the STN to cortex drive correlated with the degree of adaption achieved across subjects. These results suggest that oscillatory activity in the beta band may dynamically couple the sensorimotor cortex and basal ganglia after movements. In particular, beta activity driven from the STN to cortex indicates task-relevant movement errors, information that may be important in modifying subsequent motor responses. PMID:25505327

  11. Local Fields in Human Subthalamic Nucleus Track the Lead-up to Impulsive Choices.

    PubMed

    Pearson, John M; Hickey, Patrick T; Lad, Shivanand P; Platt, Michael L; Turner, Dennis A

    2017-01-01

    The ability to adaptively minimize not only motor but cognitive symptoms of neurological diseases, such as Parkinson's Disease (PD) and obsessive-compulsive disorder (OCD), is a primary goal of next-generation deep brain stimulation (DBS) devices. On the basis of studies demonstrating a link between beta-band synchronization and severity of motor symptoms in PD, the minimization of beta band activity has been proposed as a potential training target for closed-loop DBS. At present, no comparable signal is known for the impulsive side effects of PD, though multiple studies have implicated theta band activity within the subthalamic nucleus (STN), the site of DBS treatment, in processes of conflict monitoring and countermanding. Here, we address this challenge by recording from multiple independent channels within the STN in a self-paced decision task to test whether these signals carry information sufficient to predict stopping behavior on a trial-by-trial basis. As in previous studies, we found that local field potentials (LFPs) exhibited modulations preceding self-initiated movements, with power ramping across multiple frequencies during the deliberation period. In addition, signals showed phasic changes in power around the time of decision. However, a prospective model that attempted to use these signals to predict decision times showed effects of risk level did not improve with the addition of LFPs as regressors. These findings suggest information tracking the lead-up to impulsive choices is distributed across multiple frequency scales in STN, though current techniques may not possess sufficient signal-to-noise ratios to predict-and thus curb-impulsive behavior on a moment-to-moment basis.

  12. Aging and inhibitory control of action: cortico-subthalamic connection strength predicts stopping performance.

    PubMed

    Coxon, James P; Van Impe, Annouchka; Wenderoth, Nicole; Swinnen, Stephan P

    2012-06-13

    Diffusion weighted imaging (DWI) studies in humans have shown that seniors exhibit reduced white matter integrity compared with young adults, with the most pronounced change occurring in frontal white matter. It is generally assumed that this structural deterioration underlies inhibitory control deficits in old age, but specific evidence from a structural neuroscience perspective is lacking. Cognitive action control is thought to rely on an interconnected network consisting of right inferior frontal cortex (r-IFC), pre-supplementary motor area (preSMA), and the subthalamic nucleus (STN). Here we performed probabilistic DWI tractography to delineate this cognitive control network and had the same individuals (20 young, 20 older adults) perform a task probing both response inhibition and action reprogramming. We hypothesized that structural integrity (fractional anisotropy) and connection strength within this network would be predictive of individual and age-related differences in task performance. We show that the integrity of r-IFC white matter is an age-independent predictor of stop-signal reaction time (SSRT). We further provide evidence that the integrity of white matter projecting to STN predicts both outright stopping (SSRT) and transient braking of response initiation to buy time for action reprogramming (stopping interference effects). These associations remain even after controlling for Go task performance, demonstrating specificity to the Stop component of this task. Finally, a multiple regression analysis reveals bilateral preSMA-STN tract strength as a significant predictor of SSRT in older adults. Our data link age-related decline in inhibitory control with structural decline of STN projections.

  13. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra

    PubMed Central

    Hashiatni, Hikaru; Lang, Richard J; Suzuki, Hikaru

    2010-01-01

    BACKGROUND AND PURPOSE Although spontaneous Ca2+ waves in interstitial cells of Cajal (ICC)-like cells (ICC-LCs) primarily arise from endoplasmic reticulum (ER) Ca2+ release, the interactions among mitochondrial Ca2+ buffering, cellular energetics and ER Ca2+ release in determining the spatiotemporal dynamics of intracellular Ca2+ remain to be elucidated. EXPERIMENTAL APPROACH Spontaneous Ca2+ transients in freshly isolated ICC-LCs of the rabbit urethra were visualized using fluo-4 Ca2+ imaging, while the intracellular distribution of mitochondria was viewed with MitoTracker Red. KEY RESULTS Spontaneous Ca2+ waves invariably originated from the perinuclear region where clusters of mitochondria surround the nucleus. Perinuclear Ca2+ dynamics were characterized by a gradual rise in basal Ca2+ that preceded each regenerative Ca2+ transient. Caffeine evoked oscillatory Ca2+ waves originating from anywhere within ICC-LCs. Ryanodine or cyclopiazonic acid prevented Ca2+ wave generation with a rise in basal Ca2+, and subsequent caffeine evoked a single rudimentary Ca2+ transient. Inhibition of glycolysis with 2-deoxy-glucose or carbonyl cyanide 3-chlorophenylhydrazone, a mitochondrial protonophore, increased basal Ca2+ and abolished Ca2+ waves. However, caffeine still induced oscillatory Ca2+ transients. Mitochondrial Ca2+ uptake inhibition with RU360 attenuated Ca2+ wave amplitudes, while mitochondrial Ca2+ efflux inhibition with CGP37157 suppressed the initial Ca2+ rise to reduce Ca2+ wave frequency. CONCLUSIONS AND IMPLICATIONS Perinuclear mitochondria in ICC-LCs play a dominant role in the spatial regulation of Ca2+ wave generation and may regulate ER Ca2+ release frequency by buffering Ca2+ within microdomains between both organelles. Glycolysis inhibition reduced mitochondrial Ca2+ buffering without critically disrupting ER function. Perinuclear mitochondria may function as sensors of intracellular metabolites. PMID:20880405

  14. Sexual well being in parkinsonian patients after deep brain stimulation of the subthalamic nucleus

    PubMed Central

    Castelli, L; Perozzo, P; Genesia, M; Torre, E; Pesare, M; Cinquepalmi, A; Lanotte, M; Bergamasco, B; Lopiano, L

    2004-01-01

    Objectives: To evaluate changes in sexual well being in a group of patients with Parkinson's disease following deep brain stimulation (DBS) of the subthalamic nucleus (STN). Methods: 31 consecutive patients with Parkinson's disease (21 men and 10 women), bilaterally implanted for DBS of STN, were evaluated one month before and 9–12 months after surgery. Sexual functioning was assessed using a reduced form of the Gollombok Rust inventory of sexual satisfaction (GRISS). Depression (Beck depression inventory) and anxiety (STAI-X1/X2) were also evaluated. Relations between sexual functioning and modifications in the severity of disease (Hoehn and Yahr stage), reduction in levodopa equivalent daily dosage (LEDD), age, and duration of disease were analysed. Results: While no modifications were found in female patients, male patients reported slightly but significantly more satisfaction with their sexual life after DBS of STN. When only male patients under 60 years old were considered, a greater improvement in sexual functioning was found, though still small. Modifications in depressive symptoms and anxiety, as well as duration of the disease, reduction in LEDD, and improvement in the severity of disease, showed no relation with changes in sexual functioning after DBS of STN. Conclusions: DBS of STN appears to affect sexual functioning in a small but positive way. Male patients with Parkinson's disease, especially when under 60, appeared more satisfied with their sexual well being over a short term follow up period. PMID:15314111

  15. Open Ocean Internal Waves, South China Sea

    NASA Technical Reports Server (NTRS)

    1989-01-01

    These open ocean internal waves were seen in the south China Sea (19.5N, 114.5E). These sets of internal waves most likely coincide with tidal periods about 12 hours apart. The wave length (distance from crest to crest) varies between 1.5 and 5.0 miles and the crest lengths stretch across and beyond this photo for over 75 miles. At lower right, the surface waves are moving at a 30% angle to the internal waves, with parallel low level clouds.

  16. Trajectory description of the quantum–classical transition for wave packet interference

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chou, Chia-Chun, E-mail: ccchou@mx.nthu.edu.tw

    2016-08-15

    The quantum–classical transition for wave packet interference is investigated using a hydrodynamic description. A nonlinear quantum–classical transition equation is obtained by introducing a degree of quantumness ranging from zero to one into the classical time-dependent Schrödinger equation. This equation provides a continuous description for the transition process of physical systems from purely quantum to purely classical regimes. In this study, the transition trajectory formalism is developed to provide a hydrodynamic description for the quantum–classical transition. The flow momentum of transition trajectories is defined by the gradient of the action function in the transition wave function and these trajectories follow themore » main features of the evolving probability density. Then, the transition trajectory formalism is employed to analyze the quantum–classical transition of wave packet interference. For the collision-like wave packet interference where the propagation velocity is faster than the spreading speed of the wave packet, the interference process remains collision-like for all the degree of quantumness. However, the interference features demonstrated by transition trajectories gradually disappear when the degree of quantumness approaches zero. For the diffraction-like wave packet interference, the interference process changes continuously from a diffraction-like to collision-like case when the degree of quantumness gradually decreases. This study provides an insightful trajectory interpretation for the quantum–classical transition of wave packet interference.« less

  17. Cognitive outcome and reliable change indices two years following bilateral subthalamic nucleus deep brain stimulation.

    PubMed

    Williams, Amy E; Arzola, Gladys Marina; Strutt, Adriana M; Simpson, Richard; Jankovic, Joseph; York, Michele K

    2011-06-01

    Subthalamic nucleus deep brain stimulation (STN-DBS) is currently the treatment of choice for medication-resistant levodopa-related motor complications in patients with Parkinson's disease (PD). While STN-DBS often results in meaningful motor improvements, consensus regarding long-term neuropsychological outcome continues to be debated. We assessed the cognitive outcomes of 19 STN-DBS patients compared to a group of 18 medically-managed PD patients on a comprehensive neuropsychological battery at baseline and two years post-surgery. Patients did not demonstrate changes in global cognitive functioning on screening measures. However, neuropsychological results revealed impairments in nonverbal recall, oral information processing speed, and lexical and semantic fluency in STN-DBS patients compared to PD controls 2 years post-surgery in these preliminary analyses. Additionally, reliable change indices revealed that approximately 50% of STN-DBS patients demonstrated significant declines in nonverbal memory and oral information processing speed compared to 25-30% of PD controls, and 26% of STN-DBS patients declined on lexical fluency compared to 11% of PD patients. Approximately 30% of both groups declined on semantic fluency. The number of STN-DBS patients who converted to dementia 2 years following surgery was not significantly different from the PD participants (32% versus 16%, respectively). Our results suggest that neuropsychological evaluations may identify possible mild cognitive changes following surgery. Copyright © 2011 Elsevier Ltd. All rights reserved.

  18. Inertio Gravity Waves in the Upper Mesosphere

    NASA Technical Reports Server (NTRS)

    Mayr, H. G.; Mengel, J. G.; Talaat, E. L.; Porter, H. S.; Chan, K. L.

    2003-01-01

    In the polar region of the upper mesosphere, horizontal wind oscillations have been observed with periods around 10 hours (Hernandez et al., 1992). Such waves are generated in our Numerical Spectral Model (NSM) and appear to be inertio gravity waves (IGW). Like the planetary waves (PW) in the model, the IGWs are generated by instabilities that arise in the mean zonal circulation. In addition to stationary waves for m = 0, eastward and westward propagating waves for m = 1 to 4 appear above 70 km that grow in magnitude up to about 110 km, having periods between 9 and 11 hours. The m = 1 westward propagating IGWs have the largest amplitudes, which can reach at the poles 30 m/s. Like PWs, the IGWs are intermittent but reveal systematic seasonal variations, with the largest amplitudes occurring generally in winter and spring. The IGWs propagate upward with a vertical wavelength of about 20 km.

  19. Role of slow oscillatory activity and slow wave sleep in consolidation of episodic-like memory in rats.

    PubMed

    Oyanedel, Carlos N; Binder, Sonja; Kelemen, Eduard; Petersen, Kimberley; Born, Jan; Inostroza, Marion

    2014-12-15

    Our previous experiments showed that sleep in rats enhances consolidation of hippocampus dependent episodic-like memory, i.e. the ability to remember an event bound into specific spatio-temporal context. Here we tested the hypothesis that this enhancing effect of sleep is linked to the occurrence of slow oscillatory and spindle activity during slow wave sleep (SWS). Rats were tested on an episodic-like memory task and on three additional tasks covering separately the where (object place recognition), when (temporal memory), and what (novel object recognition) components of episodic memory. In each task, the sample phase (encoding) was followed by an 80-min retention interval that covered either a period of regular morning sleep or sleep deprivation. Memory during retrieval was tested using preferential exploration of novelty vs. familiarity. Consistent with previous findings, the rats which had slept during the retention interval showed significantly stronger episodic-like memory and spatial memory, and a trend of improved temporal memory (although not significant). Object recognition memory was similarly retained across sleep and sleep deprivation retention intervals. Recall of episodic-like memory was associated with increased slow oscillatory activity (0.85-2.0Hz) during SWS in the retention interval. Spatial memory was associated with increased proportions of SWS. Against our hypothesis, a relationship between spindle activity and episodic-like memory performance was not detected, but spindle activity was associated with object recognition memory. The results provide support for the role of SWS and slow oscillatory activity in consolidating hippocampus-dependent memory, the role of spindles in this process needs to be further examined. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  20. Moreton wave, "EIT wave", and type II radio burst as manifestations of a single wave front

    NASA Astrophysics Data System (ADS)

    Kuzmenko, I. V.; Grechnev, V. V.; Uralov, A. M.

    2011-12-01

    We show that a Moreton wave, an "EIT wave," and a type II radio burst observed during a solar flare of July 13, 2004, might have been a manifestation of a single front of a decelerating shock wave, which appeared in an active region (AR) during a filament eruption. We propose describing a quasi-spheroidal wave propagating upward and along the solar surface by using relations known from a theory of a point-like explosion in a gas whose density changes along the radius according to a power law. By applying this law to fit the drop in density of the coronal plasma enveloping the solar active region, we first managed to bring the measured positions and velocities of surface Moreton wave and "EIT wave" into correspondence with the observed frequency drift rate of the meter type II radio burst. The exponent of the vertical coronal density falloff is selected by fitting the power law to the Newkirk and Saito empirical distributions in the height range of interest. Formal use of such a dependence in the horizontal direction with a different exponent appears to be reasonable up to distances of less than 200 Mm around the eruption center. It is possible to assume that the near-surface shock wave weakens when leaving this radius and finally the active region, entering the region of the quiet Sun where the coronal plasma density and the fast-mode speed are almost constant along the horizontal.

  1. Mapping and mining interictal pathological gamma (30–100 Hz) oscillations with clinical intracranial EEG in patients with epilepsy

    PubMed Central

    Smart, Otis; Maus, Douglas; Marsh, Eric; Dlugos, Dennis; Litt, Brian; Meador, Kimford

    2012-01-01

    Localizing an epileptic network is essential for guiding neurosurgery and antiepileptic medical devices as well as elucidating mechanisms that may explain seizure-generation and epilepsy. There is increasing evidence that pathological oscillations may be specific to diseased networks in patients with epilepsy and that these oscillations may be a key biomarker for generating and indentifying epileptic networks. We present a semi-automated method that detects, maps, and mines pathological gamma (30–100 Hz) oscillations (PGOs) in human epileptic brain to possibly localize epileptic networks. We apply the method to standard clinical iEEG (<100 Hz) with interictal PGOs and seizures from six patients with medically refractory epilepsy. We demonstrate that electrodes with consistent PGO discharges do not always coincide with clinically determined seizure onset zone (SOZ) electrodes but at times PGO-dense electrodes include secondary seizure-areas (SS) or even areas without seizures (NS). In 4/5 patients with epilepsy surgery, we observe poor (Engel Class 4) post-surgical outcomes and identify more PGO-activity in SS or NS than in SOZ. Additional studies are needed to further clarify the role of PGOs in epileptic brain. PMID:23105174

  2. Cortical Plasticity Induction by Pairing Subthalamic Nucleus Deep-Brain Stimulation and Primary Motor Cortical Transcranial Magnetic Stimulation in Parkinson's Disease.

    PubMed

    Udupa, Kaviraja; Bahl, Nina; Ni, Zhen; Gunraj, Carolyn; Mazzella, Filomena; Moro, Elena; Hodaie, Mojgan; Lozano, Andres M; Lang, Anthony E; Chen, Robert

    2016-01-13

    Noninvasive brain stimulation studies have shown abnormal motor cortical plasticity in Parkinson's disease (PD). These studies used peripheral nerve stimulation paired with transcranial magnetic stimulation (TMS) to primary motor cortex (M1) at specific intervals to induce plasticity. Induction of cortical plasticity through stimulation of the basal ganglia (BG)-M1 connections has not been studied. In the present study, we used a novel technique of plasticity induction by repeated pairing of deep-brain stimulation (DBS) of the BG with M1 stimulation using TMS. We hypothesize that repeated pairing of subthalamic nucleus (STN)-DBS and M1-TMS at specific time intervals will lead to plasticity in the M1. Ten PD human patients with STN-DBS were studied in the on-medication state with DBS set to 3 Hz. The interstimulus intervals (ISIs) between STN-DBS and TMS that produced cortical facilitation were determined individually for each patient. Three plasticity induction conditions with repeated pairings (180 times) at specific ISIs (∼ 3 and ∼ 23 ms) that produced cortical facilitation and a control ISI of 167 ms were tested in random order. Repeated pairing of STN-DBS and M1-TMS at short (∼ 3 ms) and medium (∼ 23 ms) latencies increased M1 excitability that lasted for at least 45 min, whereas the control condition (fixed ISI of 167 ms) had no effect. There were no specific changes in motor thresholds, intracortical circuits, or recruitment curves. Our results indicate that paired-associative cortical plasticity can be induced by repeated STN and M1 stimulation at specific intervals. These results show that STN-DBS can modulate cortical plasticity. We introduced a new experimental paradigm to test the hypothesis that pairing subthalamic nucleus deep-brain stimulation (STN-DBS) with motor cortical transcranial magnetic stimulation (M1-TMS) at specific times can induce cortical plasticity in patients with Parkinson's disease (PD). We found that repeated pairing of STN

  3. Waves on Ice

    Atmospheric Science Data Center

    2013-04-16

    article title:  Waves on White: Ice or Clouds?     View Larger ... like a wavy cloud pattern was actually a wavy pattern on the ice surface. One of MISR's cloud classification products, the Angular Signature ...

  4. On Hokusai's Great wave off Kanagawa: localization, linearity and a rogue wave in sub-Antarctic waters.

    PubMed

    Dudley, J M; Sarano, V; Dias, F

    2013-06-20

    The Hokusai woodcut entitled The great wave off Kanagawa has been interpreted as an unusually large storm wave, likely to be classed as a rogue wave, and possibly generated from nonlinear wave dynamics (J. H. E. Cartwright and H. Nakamura, Notes Rec. R. Soc. 63 , 119-135 (2009)). In this paper, we present a complementary discussion of this hypothesis, discussing in particular how linear and nonlinear mechanisms can both contribute to the emergence of rogue wave events. By making reference to the Great wave 's simultaneous transverse and longitudinal localization, we show that the purely linear mechanism of directional focusing also predicts characteristics consistent with those of the Great wave . In addition, we discuss the properties of a particular rogue wave photographed on the open ocean in sub-Antarctic waters, which shows two-dimensional localization and breaking dynamics remarkably similar to Hokusai's depiction in the woodcut.

  5. On Hokusai's Great wave off Kanagawa: localization, linearity and a rogue wave in sub-Antarctic waters

    PubMed Central

    Dudley, J. M.; Sarano, V.; Dias, F.

    2013-01-01

    The Hokusai woodcut entitled The great wave off Kanagawa has been interpreted as an unusually large storm wave, likely to be classed as a rogue wave, and possibly generated from nonlinear wave dynamics (J. H. E. Cartwright and H. Nakamura, Notes Rec. R. Soc. 63, 119–135 (2009)). In this paper, we present a complementary discussion of this hypothesis, discussing in particular how linear and nonlinear mechanisms can both contribute to the emergence of rogue wave events. By making reference to the Great wave's simultaneous transverse and longitudinal localization, we show that the purely linear mechanism of directional focusing also predicts characteristics consistent with those of the Great wave. In addition, we discuss the properties of a particular rogue wave photographed on the open ocean in sub-Antarctic waters, which shows two-dimensional localization and breaking dynamics remarkably similar to Hokusai's depiction in the woodcut. PMID:24687148

  6. A FAST PROPAGATING EXTREME-ULTRAVIOLET WAVE ASSOCIATED WITH A MINI-FILAMENT ERUPTION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zheng Ruisheng; Jiang Yunchun; Yang Jiayan

    The fast extreme-ultraviolet (EUV) waves (>1000 km s{sup -1}) in the solar corona were very rare in the past. Taking advantage of the high temporal and spatial resolution of the Solar Dynamics Observatory observations, we present a fast EUV wave associated with a mini-filament eruption, a C1.0 flare, and a coronal mass ejection (CME) on 2011 September 30. The event took place at the periphery between two active regions (ARs). The mini-filament rapidly erupted as a blowout jet associated with a flare and a CME. The CME front was likely developed from the large-scale overlying loops. The wave onset wasmore » nearly simultaneous with the start of the jet and the flare. The wave departed far from the flare center and showed a close location relative to the rapid jet. The wave had an initial speed of about 1100 km s{sup -1} and a slight deceleration in the last phase, and the velocity decreased to about 500 km s{sup -1}. The wave propagated in a narrow angle extent, likely to avoid the ARs on both sides. All the results provide evidence that the fast EUV wave was a fast-mode MHD wave. The wave resisted being driven by the CME, because it opened up the large-scale loops and its front likely formed later than the wave. The wave was most likely triggered by the jet, due to their close timing and location relations.« less

  7. How to Use a Candle to Study Sound Waves

    ERIC Educational Resources Information Center

    Carvalho, P. Simeão; Briosa, E.; Rodrigues, M.; Pereira, C.; Ataíde, M.

    2013-01-01

    It is well known that sound waves in air are longitudinal waves. Although teachers use analogies such as compressing horizontal springs to demonstrate what longitudinal waves look like, students still present some difficulty in understanding that (1) sound waves correspond to oscillations of air particles, and (2) there is no "air flow"…

  8. Observations of Secondary Waves Generated from Interaction Between the 2-Day Wave and the Migrating Diurnal Tide.

    NASA Astrophysics Data System (ADS)

    Lieberman, R. S.; Riggin, D. M.; Siskind, D. E.; Nguyen, V.; Palo, S. E.; Mitchell, N. J.; Livesey, N. J.; Stober, G.; Wilhelm, S.; Jacobi, C.

    2015-12-01

    Nonlinear coupling between the migrating diurnal tide and the westward traveling quasi-2-day wave yields a westward-traveling "sum" wave with zonal wavenumber 4 and a period of 16 hours, and an eastward-traveling "difference" wave with a zonal wavenumber 2 and a period of 2 days. While the eastward 2-day wave has been reported in TIMED/SABER temperatures, the westward 16-hour wave lies outside SABER's Nyquist limits of resolution. To obtain simultaneous definitions of the parent and child waves, we examine hourly output from NOGAPS-ALPHA during January 2005, 2006 and 2008. The westward 16-hour wave maximizes in the winter hemisphere, and behaves like an inertia-gravity wave. The eastward 2-day wave maximizes at low latitudes, and exhibits a mixture of Kelvin and higher-order modes. The 16-hour and the eastward 2-day waves are of comparable magnitude, and alias to the same apparent frequency when viewed from the satellite perspective.

  9. Open ocean Internal Waves, Namibia Coast, Africa.

    NASA Image and Video Library

    1990-12-10

    These open ocean Internal Waves were seen off the Namibia Coast, Africa (23.0S, 14.0E). The periodic and regularly spaced sets of internal waves most likely coincide with tidal periods about 12 hours apart. The wave length (distance from crest to crest) varies between 1.5 and 5.0 miles and the crest lengths stretch across and beyond the distance of the photo. The waves are intersecting the Namibia coastline at about a 30 degree angle.

  10. Open ocean Internal Waves, Namibia Coast, Africa.

    NASA Technical Reports Server (NTRS)

    1990-01-01

    These open ocean Internal Waves were seen off the Namibia Coast, Africa (23.0S, 14.0E). The periodic and regularly spaced sets of internal waves most likely coincide with tidal periods about 12 hours apart. The wave length (distance from crest to crest) varies between 1.5 and 5.0 miles and the crest lengths stretch across and beyond the distance of the photo. The waves are intersecting the Namibia coastline at about a 30 degree angle.

  11. Analogy between electromagnetic potentials and wave-like dynamic variables with connections to quantum theory

    NASA Astrophysics Data System (ADS)

    Yang, Chen

    2018-05-01

    The transitions from classical theories to quantum theories have attracted many interests. This paper demonstrates the analogy between the electromagnetic potentials and wave-like dynamic variables with their connections to quantum theory for audiences at advanced undergraduate level and above. In the first part, the counterpart relations in the classical electrodynamics (e.g. gauge transform and Lorenz condition) and classical mechanics (e.g. Legendre transform and free particle condition) are presented. These relations lead to similar governing equations of the field variables and dynamic variables. The Lorenz gauge, scalar potential and vector potential manifest a one-to-one similarity to the action, Hamiltonian and momentum, respectively. In the second part, the connections between the classical pictures of electromagnetic field and particle to quantum picture are presented. By characterising the states of electromagnetic field and particle via their (corresponding) variables, their evolution pictures manifest the same algebraic structure (isomorphic). Subsequently, pictures of the electromagnetic field and particle are compared to the quantum picture and their interconnections are given. A brief summary of the obtained results are presented at the end of the paper.

  12. Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury.

    PubMed

    Lobenwein, Daniela; Tepeköylü, Can; Kozaryn, Radoslaw; Pechriggl, Elisabeth J; Bitsche, Mario; Graber, Michael; Fritsch, Helga; Semsroth, Severin; Stefanova, Nadia; Paulus, Patrick; Czerny, Martin; Grimm, Michael; Holfeld, Johannes

    2015-10-27

    Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular aortic repair. Shock wave treatment was shown to induce angiogenesis and regeneration in ischemic tissue by modulation of early inflammatory response via Toll-like receptor (TLR) 3 signaling. In preclinical and clinical studies, shock wave treatment had a favorable effect on ischemic myocardium. We hypothesized that shock wave treatment also may have a beneficial effect on spinal cord ischemia. A spinal cord ischemia model in mice and spinal slice cultures ex vivo were performed. Treatment groups received immediate shock wave therapy, which resulted in decreased neuronal degeneration and improved motor function. In spinal slice cultures, the activation of TLR3 could be observed. Shock wave effects were abolished in spinal slice cultures from TLR3(-/-) mice, whereas the effect was still present in TLR4(-/-) mice. TLR4 protein was found to be downregulated parallel to TLR3 signaling. Shock wave-treated animals showed significantly better functional outcome and survival. The protective effect on neurons could be reproduced in human spinal slices. Shock wave treatment protects from neuronal degeneration via TLR3 signaling and subsequent TLR4 downregulation. Consequently, it represents a promising treatment option for the devastating complication of spinal cord ischemia after aortic repair. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  13. Deep brain stimulation modulates synchrony within spatially and spectrally distinct resting state networks in Parkinson’s disease

    PubMed Central

    Oswal, Ashwini; Beudel, Martijn; Zrinzo, Ludvic; Limousin, Patricia; Hariz, Marwan; Foltynie, Tom; Litvak, Vladimir

    2016-01-01

    Abstract Chronic dopamine depletion in Parkinson’s disease leads to progressive motor and cognitive impairment, which is associated with the emergence of characteristic patterns of synchronous oscillatory activity within cortico-basal-ganglia circuits. Deep brain stimulation of the subthalamic nucleus is an effective treatment for Parkinson’s disease, but its influence on synchronous activity in cortico-basal-ganglia loops remains to be fully characterized. Here, we demonstrate that deep brain stimulation selectively suppresses certain spatially and spectrally segregated resting state subthalamic nucleus–cortical networks. To this end we used a validated and novel approach for performing simultaneous recordings of the subthalamic nucleus and cortex using magnetoencephalography (during concurrent subthalamic nucleus deep brain stimulation). Our results highlight that clinically effective subthalamic nucleus deep brain stimulation suppresses synchrony locally within the subthalamic nucleus in the low beta oscillatory range and furthermore that the degree of this suppression correlates with clinical motor improvement. Moreover, deep brain stimulation relatively selectively suppressed synchronization of activity between the subthalamic nucleus and mesial premotor regions, including the supplementary motor areas. These mesial premotor regions were predominantly coupled to the subthalamic nucleus in the high beta frequency range, but the degree of deep brain stimulation-associated suppression in their coupling to the subthalamic nucleus was not found to correlate with motor improvement. Beta band coupling between the subthalamic nucleus and lateral motor areas was not influenced by deep brain stimulation. Motor cortical coupling with subthalamic nucleus predominantly involved driving of the subthalamic nucleus, with those drives in the higher beta frequency band having much shorter net delays to subthalamic nucleus than those in the lower beta band. These

  14. Key role of the expression of bone morphogenetic proteins in increasing the osteogenic activity of osteoblast-like cells exposed to shock waves and seeded on bioactive glass-ceramic scaffolds for bone tissue engineering.

    PubMed

    Muzio, Giuliana; Martinasso, Germana; Baino, Francesco; Frairia, Roberto; Vitale-Brovarone, Chiara; Canuto, Rosa A

    2014-11-01

    In this work, the role of shock wave-induced increase of bone morphogenetic proteins in modulating the osteogenic properties of osteoblast-like cells seeded on a bioactive scaffold was investigated using gremlin as a bone morphogenetic protein antagonist. Bone-like glass-ceramic scaffolds, based on a silicate experimental bioactive glass developed at the Politecnico di Torino, were produced by the sponge replication method and used as porous substrates for cell culture. Human MG-63 cells, exposed to shock waves and seeded on the scaffolds, were treated with gremlin every two days and analysed after 20 days for the expression of osteoblast differentiation markers. Shock waves have been shown to induce osteogenic activity mediated by increased expression of alkaline phosphatase, osteocalcin, type I collagen, BMP-4 and BMP-7. Cells exposed to shock waves plus gremlin showed increased growth in comparison with cells treated with shock waves alone and, conversely, mRNA contents of alkaline phosphatase and osteocalcin were significantly lower. Therefore, the shock wave-mediated increased expression of bone morphogenetic protein in MG-63 cells seeded on the scaffolds is essential in improving osteogenic activity; blocking bone morphogenetic protein via gremlin completely prevents the increase of alkaline phosphatase and osteocalcin. The results confirmed that the combination of glass-ceramic scaffolds and shock waves exposure could be used to significantly improve osteogenesis opening new perspectives for bone regenerative medicine. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  15. Evolving Concepts in Posterior Subthalamic Area Deep Brain Stimulation for Treatment of Tremor: Surgical Neuroanatomy and Practical Considerations.

    PubMed

    Ramirez-Zamora, Adolfo; Smith, Heather; Kumar, Vignessh; Prusik, Julia; Phookan, Sujoy; Pilitsis, Julie G

    2016-01-01

    Although thalamic deep brain stimulation (DBS) has been established as an effective therapy for refractory tremor in Parkinson's disease and essential tremor, reports investigating the efficacy of posterior subthalamic area (PSA) DBS for severe, debilitating tremors continue to emerge. However, questions regarding the optimal anatomical target, surgical approach, programming paradigms and effectiveness compared to other targets remain. In this report, we aimed to review the current literature to assess different stereotactic techniques, anatomical considerations, adverse effects and stimulation settings in PSA DBS. A comprehensive literature review was performed searching for articles discussing tremors and PSA stimulation. We performed a quantitative analysis comparing different DBS tremor targets. Tremor improvement is consistently documented in most reports with an average reduction in tremor of 79% depending on the specific tremor syndrome. Tremor benefit in patients with multiple sclerosis (MS) tremor was significantly higher than for other stimulation targets. Transient paresthesias, imbalance, dizziness and dysarthria are the most common side effects with PSA DBS. PSA DBS is an effective and safe treatment for tremor control and should be considered in patients with refractory tremors with associated cerebellar or dystonic features, proximal tremors and MS tremor. © 2016 S. Karger AG, Basel.

  16. Therapeutic high-frequency stimulation of the subthalamic nucleus in Parkinson's disease produces global increases in cerebral blood flow.

    PubMed

    Sidtis, John J; Tagliati, Michele; Alterman, Ron; Sidtis, Diana; Dhawan, Vijay; Eidelberg, David

    2012-01-01

    Chronic, high-frequency electrical stimulation of the subthalamic nuclei (STNs) has become an effective and widely used therapy in Parkinson's disease (PD), but the therapeutic mechanism is not understood. Stimulation of the STN is believed to reorganize neurophysiological activity patterns within the basal ganglia, whereas local field effects extending to tracts adjacent to the STN are viewed as sources of nontherapeutic side effects. This study is part of a larger project investigating the effects of STN stimulation on speech and regional cerebral blood flow (CBF) in human subjects with PD. While generating measures of global CBF (gCBF) to normalize regional CBF values for a subsequent combined analysis of regional CBF and speech data, we observed a third effect of this therapy: a gCBF increase. This effect was present across three estimates of gCBF ranging from values based on the highest activity voxels to those based on all voxels. The magnitude of the gCBF increase was related to the subject's duration of PD. It is not clear whether this CBF effect has a therapeutic role, but the impact of deep brain stimulation on cerebrovascular control warrants study from neuroscience, pathophysiological, and therapeutic perspectives.

  17. Alfven wave refraction by interplanetary inhomogeneities

    NASA Technical Reports Server (NTRS)

    Daily, W. D.

    1973-01-01

    Pioneer 6 magnetic data reveals that the propagation direction of Alfven waves in the interplanetary medium is strongly oriented along the ambient field. Magnetic fluctuations of frequencies up to 1/30 sec in the spacecraft frame are shown to satisfy a necessary condition for Alfven wave normal. It appears from this analysis that geometrical hydromagnetics may satisfactorily describe deviation of the wave normal from the background field. The rotational discontinuity is likely also to propagate along the field lines.

  18. High-frequency Plasma Waves Associated with Magnetic Reconnection in the Solar Wind

    NASA Astrophysics Data System (ADS)

    Wang, Y.

    2015-12-01

    Activities of high-frequency plasma waves associated with magnetic reconnection in the solar wind observed by Time Domain Sampler (TDS) experiments on STEREO/WAVES are preliminarily analyzed. The TDS instrument can provide burst mode electric fields data with as long as 16384 sample points at 250 kHz sampling rate. In all 1120 suspected reconnection events, it is found that the most commonly occurred waves are neither ion acoustic waves, electrostatic solitary waves, nor Langmuir/upper hybrid waves, but Bernstein-like waves with harmonics of the electron cyclotron frequency. In addition, to each type of waves, Langmuir/upper hybrid waves reveal the largest occurrence rate in the reconnection region than in the ambient solar wind. These results indicate that Bernstein-like waves and Langmuir/upper hybrid waves might play important roles in the reconnection associated particle heating processes and they might also influence the dissipation of magnetic reconnection.

  19. Freak waves in random oceanic sea states.

    PubMed

    Onorato, M; Osborne, A R; Serio, M; Bertone, S

    2001-06-18

    Freak waves are very large, rare events in a random ocean wave train. Here we study their generation in a random sea state characterized by the Joint North Sea Wave Project spectrum. We assume, to cubic order in nonlinearity, that the wave dynamics are governed by the nonlinear Schrödinger (NLS) equation. We show from extensive numerical simulations of the NLS equation how freak waves in a random sea state are more likely to occur for large values of the Phillips parameter alpha and the enhancement coefficient gamma. Comparison with linear simulations is also reported.

  20. Stop! border ahead: Automatic detection of subthalamic exit during deep brain stimulation surgery.

    PubMed

    Valsky, Dan; Marmor-Levin, Odeya; Deffains, Marc; Eitan, Renana; Blackwell, Kim T; Bergman, Hagai; Israel, Zvi

    2017-01-01

    Microelectrode recordings along preplanned trajectories are often used for accurate definition of the subthalamic nucleus (STN) borders during deep brain stimulation (DBS) surgery for Parkinson's disease. Usually, the demarcation of the STN borders is performed manually by a neurophysiologist. The exact detection of the borders is difficult, especially detecting the transition between the STN and the substantia nigra pars reticulata. Consequently, demarcation may be inaccurate, leading to suboptimal location of the DBS lead and inadequate clinical outcomes. We present machine-learning classification procedures that use microelectrode recording power spectra and allow for real-time, high-accuracy discrimination between the STN and substantia nigra pars reticulata. A support vector machine procedure was tested on microelectrode recordings from 58 trajectories that included both STN and substantia nigra pars reticulata that achieved a 97.6% consistency with human expert classification (evaluated by 10-fold cross-validation). We used the same data set as a training set to find the optimal parameters for a hidden Markov model using both microelectrode recording features and trajectory history to enable real-time classification of the ventral STN border (STN exit). Seventy-three additional trajectories were used to test the reliability of the learned statistical model in identifying the exit from the STN. The hidden Markov model procedure identified the STN exit with an error of 0.04 ± 0.18 mm and detection reliability (error < 1 mm) of 94%. The results indicate that robust, accurate, and automatic real-time electrophysiological detection of the ventral STN border is feasible. © 2016 International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder Society.

  1. Subthalamic nucleus stimulation does not influence basal glucose metabolism or insulin sensitivity in patients with Parkinson's disease.

    PubMed

    Lammers, Nicolette M; Sondermeijer, Brigitte M; Twickler, Th B Marcel; de Bie, Rob M; Ackermans, Mariëtte T; Fliers, Eric; Schuurman, P Richard; La Fleur, Susanne E; Serlie, Mireille J

    2014-01-01

    Animal studies have shown that central dopamine signaling influences glucose metabolism. As a first step to show this association in an experimental setting in humans, we studied whether deep brain stimulation (DBS) of the subthalamic nucleus (STN), which modulates the basal ganglia circuitry, alters basal endogenous glucose production (EGP) or insulin sensitivity in patients with Parkinson's disease (PD). We studied 8 patients with PD treated with DBS STN, in the basal state and during a hyperinsulinemic euglycemic clamp using a stable glucose isotope, in the stimulated and non-stimulated condition. We measured EGP, hepatic insulin sensitivity, peripheral insulin sensitivity (Rd), resting energy expenditure (REE), glucoregulatory hormones, and Parkinson symptoms, using the Unified Parkinson's Disease Rating Scale (UPDRS). Basal plasma glucose and EGP did not differ between the stimulated and non-stimulated condition. Hepatic insulin sensitivity was similar in both conditions and there were no significant differences in Rd and plasma glucoregulatory hormones between DBS on and DBS off. UPDRS was significantly higher in the non-stimulated condition. DBS of the STN in patients with PD does not influence basal EGP or insulin sensitivity. These results suggest that acute modulation of the motor basal ganglia circuitry does not affect glucose metabolism in humans.

  2. Nonlinear Waves and Inverse Scattering

    DTIC Science & Technology

    1990-09-18

    to be published Proceedings: conference Chaos in Australia (February 1990). 5. On the Kadomtsev Petviashvili Equation and Associated Constraints by...Scattering Transfoni (IST). IST is a method which alows one to’solve nonlinear wave equations by solving certain related direct and inverse scattering...problems. We use these results to find solutions to nonlinear wave equations much like one uses Fourier analysis for linear problems. Moreover the

  3. Physics, Astrophysics and Cosmology with Gravitational Waves.

    PubMed

    Sathyaprakash, B S; Schutz, Bernard F

    2009-01-01

    Gravitational wave detectors are already operating at interesting sensitivity levels, and they have an upgrade path that should result in secure detections by 2014. We review the physics of gravitational waves, how they interact with detectors (bars and interferometers), and how these detectors operate. We study the most likely sources of gravitational waves and review the data analysis methods that are used to extract their signals from detector noise. Then we consider the consequences of gravitational wave detections and observations for physics, astrophysics, and cosmology.

  4. Conway Morris: Extraterrestrials: Aliens like us?

    NASA Astrophysics Data System (ADS)

    Morris, Simon Conway

    2005-08-01

    So what are they going to be like, those long-expected extraterrestrials? Hideous hydrocarbon arachnoids, waving laser cannons as they chase screaming humans, repulsively surveying the scene through empathy-free compound eyes? Or maybe laughing bipeds, chatting away, holding a glass of wine, a bit like us?

  5. Wave rotor-enhanced gas turbine engines

    NASA Technical Reports Server (NTRS)

    Welch, Gerard E.; Scott, Jones M.; Paxson, Daniel E.

    1995-01-01

    The benefits of wave rotor-topping in small (400 to 600 hp-class) and intermediate (3000 to 4000 hp-class) turboshaft engines, and large (80,000 to 100,000 lb(sub f)-class) high bypass ratio turbofan engines are evaluated. Wave rotor performance levels are calculated using a one-dimensional design/analysis code. Baseline and wave rotor-enhanced engine performance levels are obtained from a cycle deck in which the wave rotor is represented as a burner with pressure gain. Wave rotor-toppings is shown to significantly enhance the specific fuel consumption and specific power of small and intermediate size turboshaft engines. The specific fuel consumption of the wave rotor-enhanced large turbofan engine can be reduced while operating at significantly reduced turbine inlet temperature. The wave rotor-enhanced engine is shown to behave off-design like a conventional engine. Discussion concerning the impact of the wave rotor/gas turbine engine integration identifies tenable technical challenges.

  6. Selective left, right and bilateral stimulation of subthalamic nuclei in Parkinson's disease: differential effects on motor, speech and language function.

    PubMed

    Schulz, Geralyn M; Hosey, Lara A; Bradberry, Trent J; Stager, Sheila V; Lee, Li-Ching; Pawha, Rajesh; Lyons, Kelly E; Metman, Leo Verhagen; Braun, Allen R

    2012-01-01

    Deep brain stimulation (DBS) of the subthalamic nucleus improves the motor symptoms of Parkinson's disease, but may produce a worsening of speech and language performance at rates and amplitudes typically selected in clinical practice. The possibility that these dissociated effects might be modulated by selective stimulation of left and right STN has never been systematically investigated. To address this issue, we analyzed motor, speech and language functions of 12 patients implanted with bilateral stimulators configured for optimal motor responses. Behavioral responses were quantified under four stimulator conditions: bilateral DBS, right-only DBS, left-only DBS and no DBS. Under bilateral and left-only DBS conditions, our results exhibited a significant improvement in motor symptoms but worsening of speech and language. These findings contribute to the growing body of literature demonstrating that bilateral STN DBS compromises speech and language function and suggests that these negative effects may be principally due to left-sided stimulation. These findings may have practical clinical consequences, suggesting that clinicians might optimize motor, speech and language functions by carefully adjusting left- and right-sided stimulation parameters.

  7. Tidal waves within the thermosphere. [emphasizing wave dissipation and diffusion

    NASA Technical Reports Server (NTRS)

    Volland, H.; Mayr, H. G.

    1974-01-01

    The eigenfunctions of the atmosphere (the Hough functions within the lower atmosphere below about 100 km) change their structure and their propagation characteristics within the thermosphere due to dissipation effects such as heat conduction, viscosity, and ion drag. Wave dissipation can be parameterized to a first-order approximation by a complex frequency, the imaginary term of which simulates an effective ion drag force. It is shown how the equivalent depth, the attenuation, and the vertical wavelength of the predominant symmetric diurnal tidal modes change with height as functions of effective ion drag. The boundary conditions of tidal waves are discussed, and asymptotic solutions for the wave parameters like pressure, density, temperature, and wind generated by a heat input proportional to the mean pressure are given. Finally, diffusion effects upon the minor constituents within the thermosphere are described.

  8. Incident wave, infragravity wave, and non-linear low-frequency bore evolution across fringing coral reefs

    NASA Astrophysics Data System (ADS)

    Storlazzi, C. D.; Griffioen, D.; Cheriton, O. M.

    2016-12-01

    Coral reefs have been shown to significantly attenuate incident wave energy and thus provide protection for 100s of millions of people globally. To better constrain wave dynamics and wave-driven water levels over fringing coral reefs, a 4-month deployment of wave and tide gauges was conducted across two shore-normal transects on Roi-Namur Island and two transects on Kwajalein Island in the Republic of the Marshall Islands. At all locations, although incident wave (periods <25 s) heights were an order of magnitude greater than infragravity wave (periods > 250 s) heights on the outer reef flat just inshore of the zone of wave breaking, the infragravity wave heights generally equaled the incident wave heights by the middle of the reef flat and exceeded the incident wave heights on the inner reef flat by the shoreline. The infragravity waves generally were asymmetric, positively skewed, bore-like forms with incident-band waves riding the infragravity wave crest at the head of the bore; these wave packets have similar structure to high-frequency internal waves on an internal wave bore. Bore height was shown to scale with water depth, offshore wave height, and offshore wave period. For a given tidal elevation, with increasing offshore wave heights, such bores occurred more frequently on the middle reef flat, whereas they occurred less frequently on the inner reef flat. Skewed, asymmetric waves are known to drive large gradients in velocity and shear stress that can transport material onshore. Thus, a better understanding of these low-frequency, energetic bores on reef flats is critical to forecasting how coral reef-lined coasts may respond to sea-level rise and climate change.

  9. Effects of varying subthalamic nucleus stimulation on apraxia of lid opening in Parkinson's disease.

    PubMed

    Tommasi, Giorgio; Krack, Paul; Fraix, Valérie; Pollak, Pierre

    2012-09-01

    Apraxia of lid opening (ALO) is a non-paralytic inability to open the eyes or sustain lid elevation at will. The exact pathophysiological mechanisms underlying the syndrome are still unknown. ALO has been reported in patients with Parkinson's disease (PD) after subthalamic nucleus (STN) deep brain stimulation (DBS), suggesting a possible involvement of the basal ganglia. We aimed to assess the effects of varying STN stimulation voltage on ALO in PD patients. Seven out of 14 PD patients with bilateral STN stimulation consecutively seen in our centre presented with ALO. We progressively increased voltage on each STN, using either 130 Hz (high-frequency stimulation, HFS) or 2 or 3 Hz (low-frequency stimulation, LFS). In five patients, HFS induced ALO time-locked to stimulation in 7 out of 10 STNs at a voltage higher than that used for chronic stimulation. LFS induced myoclonus in the pretarsal orbicularis oculi muscle (pOOm) with a rhythm synchronous to the frequency. In the other two patients with ALO already present at the time of the study, HFS improved ALO in 3 out of 4 STNs. ALO recurred within minutes of stimulation arrest. Our findings show that STN-DBS can have opposite effects on ALO. On the one hand, ALO is thought to be a corticobulbar side effect due to lateral current spreading from the STN, in which case it is necessary to use voltages below the ALO-inducing threshold. On the other hand, ALO may be considered a form of off-phase focal dystonia possibly improved by increasing the stimulation voltages.

  10. A coupled atmosphere-ocean-wave modeling approach for a Tropical Like Cyclone in the Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Ricchi, Antonio; Miglietta, M. Marcello; Barbariol, Francesco; Benetazzo, Alvise; Bonaldo, Davide; Falcieri, Francesco; Russo, Aniello; Sclavo, Mauro; Carniel, Sandro

    2016-04-01

    In November 6-8, 2011, in the Balearic islands an extra-tropical depression developed into a Tropical-Like Cyclone (TLC) characterized by a deep-warm core, leading to a mean sea level pressure minimum of about 991 hPa, 10 m wind speeds higher than 28 m/s around the eye, and very intense rainfall, especially in the Gulf of Lion. To explore in detail the effect of the sea surface temperature on the Medicane evolution, we employed the coupled modeling system COAWST, which consists of the ROMS model for the hydrodynamic part, the WRF model for the meteorological part, and the SWAN for the surface wave modeling. All model run over 5 km domain (same domain for ROMS and SWAN). COAWST was used with different configurations: in Stand Alone (SA) mode (that is, with only the atmospheric part), in atmosphere-ocean coupled mode (AO), and in a fully coupled version including also surface waves (AOW). Several sensitivity simulations performed with the SA approach were undertaken to simulate the TLC evolution. Especially in the later stage of the lifetime, when the cyclone was weaker, the predictability appears limited. Sensitivity simulations have considered the effect of the cumulus scheme (using an explicit scheme the Medicane does not develop and remains an extra-tropical depression) and the PBL scheme (using MYJ or MYNN resulting "Medicane" are extremely similar, although the roughness appears rather different among the two experiments). Comparing the three runs, the effects of different simulations on the Medicane tracks are significant only in the later stage of the cyclone lifetime. In the overall modeled basin, wind intensity is higher in the SA case w.r.t. both coupled runs. When compared to case AO, winds are about 1 m/s larger, even though the spatial distribution is very similar (possibly because of the lower SST produced by case AO). Case AOW produces less intense winds then SA and AO case in the areas where the wave is most developed (differences are about 2-4 m

  11. Do the freak waves exist in soliton gas?

    NASA Astrophysics Data System (ADS)

    Shurgalina, Ekaterina; Pelinovsky, Efim

    2016-04-01

    The possibility of short-lived anomalous large waves (rogue waves) in soliton gas in the frameworks of integrable models like the Korteweg - de Vries - type equations is studied. It is shown that the dynamics of heteropolar soliton gas differs sufficiently from the dynamics of unipolar soliton fields. In particular, in the wave fields consisting of solitons with different polarities the freak wave appearance is possible. It is shown numerically in [Shurgalina and Pelinovsky, 2015]. Freak waves in the framework of the modified Korteweg-de Vries equation have been studied previously in the case of narrowband initial conditions [Grimshaw et al, 2005, 2010; Talipova, 2011]. In this case, the mechanism of freak wave generation was modulation instability of modulated quasi-sinusoidal wave packets. At the same time the modulation instability of modulated cnoidal waves was studied in the mathematical work [Driscoll & O'Neil, 1976]. Since a sequence of solitary waves can be a special case of cnoidal wave, the modulation instability can be a possible mechanism of freak wave appearance in a soliton gas. Thus, we expect that rogue wave phenomenon in soliton gas appears in nonlinear integrable models admitting an existence of modulation instability of periodic waves (like cnoidal waves). References: 1. Shurgalina E.G., Pelinovsky E.N. Dynamics of irregular wave ensembles in the coastal zone, Nizhny Novgorod State Technical University n.a. R.E. Alekseev. - Nizhny Novgorod, 2015, 179 pp. 2. Grimshaw R., Pelinovsky E., Talipova T., Sergeeva A. Rogue internal waves in the ocean: long wave model. European Physical Journal Special Topics, 2010, 185, 195 - 208. 3. Grimshaw R., Pelinovsky E., Talipova T., Ruderman M. Erdelyi R. Short-lived large-amplitude pulses in the nonlinear long-wave model described by the modified Korteweg-de Vries equation. Studied Applied Mathematics, 2005, 114 (2), 189. 4. Talipova T.G. Mechanisms of internal freak waves, Fundamental and Applied Hydrophysics

  12. Rogue Waves in the Ocean

    NASA Astrophysics Data System (ADS)

    Waseda, Takuji

    2010-03-01

    Giant episodic ocean waves that suddenly soar like a wall of water out of an otherwise calm sea are not just a legend. Such waves—which in the past have been called “abnormal,” “exceptional,” “extreme,” and even “vicious killer” waves—are now commonly known as “rogue waves” or “freak waves.” These waves have sunk or severely damaged 22 supercarriers in the world and caused the loss of more than 500 lives in the past 40 years. The largest wave registered by reliable instruments reached 30 meters in height, and the largest wave recorded by visual observation reached about 34 meters, equivalent to the height of an eight-story building. Tales of seafarers from Christopher Columbus to the passengers of luxury cruise ships had long been undervalued by scientists, but in the past 10 or so years, those historical notes and modern testimonies have been scientifically dissected to reveal the nature of these monster waves.

  13. Deep brain stimulation of the subthalamic nucleus modulates reward processing and action selection in Parkinson patients.

    PubMed

    Wagenbreth, Caroline; Zaehle, Tino; Galazky, Imke; Voges, Jürgen; Guitart-Masip, Marc; Heinze, Hans-Jochen; Düzel, Emrah

    2015-06-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for motor impairments in Parkinson's disease (PD) but its effect on the motivational regulation of action control is still not fully understood. We investigated whether DBS of the STN influences the ability of PD patients to act for anticipated reward or loss, or whether DBS improves action execution independent of motivational valence. 16 PD patients (12 male, mean age = 58.5 ± 10.17 years) treated with bilateral STN-DBS and an age- and gender-matched group of healthy controls (HC) performed a go/no-go task whose contingencies explicitly decouple valence and action. Patients were tested with (ON) and without (OFF) active STN stimulation. For HC, there was a benefit in performing rewarded actions when compared to actions that avoided punishment. PD patients showed such a benefit reliably only when STN stimulation was ON. In fact, the relative behavioral benefit for go for reward over go to avoid losing was stronger in the PD patients under DBS ON than in HC. In PD patients, rather than generally improving motor functions independent of motivational valence, modulation of the STN by DBS improves action execution specifically when rewards are anticipated. Thus, STN-DBS establishes a reliable congruency between action and reward ("Pavlovian congruency") and remarkably enhances it over the level observed in HC.

  14. Association between subthalamic nucleus deep brain stimulation and weight gain: Results of a case-control study.

    PubMed

    Strowd, Roy E; Herco, Maja; Passmore-Griffin, Leah; Avery, Bradley; Haq, Ihtsham; Tatter, Stephen B; Tate, Jessica; Siddiqui, Mustafa S

    2016-01-01

    To evaluate whether weight change in patients with Parkinson's disease (PD) is different in those undergoing deep brain stimulation (DBS) of the subthalamic nucleus (STN) compared to those not undergoing DBS. A retrospective case-control study was performed in PD patients who had undergone STN DBS (cases) compared to matched PD patients without DBS (controls). Demographic and clinical data including Unified Parkinson's Disease Rating Scale (UPDRS) motor scores were collected. Repeated measures mixed model regression was used to identify variables associated with weight gain. Thirty-five cases and 34 controls were identified. Baseline age, gender, diagnosis and weight were similar. Duration of diagnosis was longer in cases (6.3 vs 4.9 years, p=0.0015). At 21.3 months, cases gained 2.9 kg (+4.65%) while controls lost 1.8 kg (-3.05%, p<0.02). Postoperative UPDRS motor scores improved by 49% indicating surgical efficacy. Only younger age (p=0.0002) and DBS (p=0.008) were significantly associated with weight gain. In this case-control study, PD patients undergoing STN DBS experienced post-operative weight gain that was significantly different from the weight loss observed in non-DBS PD controls. Patients, especially overweight individuals, should be informed that STN DBS can result in weight gain. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Parkinsonian rest tremor can be detected accurately based on neuronal oscillations recorded from the subthalamic nucleus.

    PubMed

    Hirschmann, J; Schoffelen, J M; Schnitzler, A; van Gerven, M A J

    2017-10-01

    To investigate the possibility of tremor detection based on deep brain activity. We re-analyzed recordings of local field potentials (LFPs) from the subthalamic nucleus in 10 PD patients (12 body sides) with spontaneously fluctuating rest tremor. Power in several frequency bands was estimated and used as input to Hidden Markov Models (HMMs) which classified short data segments as either tremor-free rest or rest tremor. HMMs were compared to direct threshold application to individual power features. Applying a threshold directly to band-limited power was insufficient for tremor detection (mean area under the curve [AUC] of receiver operating characteristic: 0.64, STD: 0.19). Multi-feature HMMs, in contrast, allowed for accurate detection (mean AUC: 0.82, STD: 0.15), using four power features obtained from a single contact pair. Within-patient training yielded better accuracy than across-patient training (0.84vs. 0.78, p=0.03), yet tremor could often be detected accurately with either approach. High frequency oscillations (>200Hz) were the best performing individual feature. LFP-based markers of tremor are robust enough to allow for accurate tremor detection in short data segments, provided that appropriate statistical models are used. LFP-based markers of tremor could be useful control signals for closed-loop deep brain stimulation. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

  16. Patterns in the Waves

    NASA Astrophysics Data System (ADS)

    Coco, G.; Guza, R. T.; Garnier, R.; Lomonaco, P.; Lopez De San Roman Blanco, B.; Dalrymple, R. A.; Xu, M.

    2014-12-01

    subharmonics long enough to build cups, are abundantly present with an incident plane wave, but lacking in many natural settings. Although subharmonic edge waves can potentially start the initial spacing, positive feedback between flow and morphology are likely critical to cusp growth.

  17. Subthalamic Nucleus Local Field Potential Activity Helps Encode Motor Effort Rather Than Force in Parkinsonism

    PubMed Central

    Pogosyan, Alek; Ashkan, Keyoumars; Cheeran, Binith; FitzGerald, James J.; Green, Alexander L.; Aziz, Tipu; Foltynie, Thomas; Limousin, Patricia; Zrinzo, Ludvic; Brown, Peter

    2015-01-01

    Local field potential (LFP) recordings from patients with deep brain stimulation electrodes in the basal ganglia have suggested that frequency-specific activities correlate with force or effort, but previous studies have not been able to disambiguate the two. Here, we dissociated effort from actual force generated by contrasting the force generation of different fingers while recording LFP activity from the subthalamic nucleus (STN) in patients with Parkinson's disease who had undergone functional surgery. Patients were studied while on their normal dopaminergic medication. We investigated the relationship between frequency-specific oscillatory activity in the STN and voluntary flexion of either the index or little finger at different effort levels. At each tested effort level (10%, 25%, and 40% of the maximal voluntary contraction force of each individual finger), the index finger generated larger force than the little finger. Movement-related suppression of beta-band power in the STN LFP was significantly modulated by effort, but not by which finger was used, suggesting that the beta suppression in the STN LFP during sustained contraction serves as a proxy for effort. The absolute force scaled with beta power suppression, but with the scaling determined by the maximal voluntary contraction force of the motor effector. Our results argue against the hypothesis that the basal ganglia are directly involved in the parameterization of force during movement and support a role of the STN in the control of motor effort to be attributed to a response. PMID:25878267

  18. No Effect of Subthalamic Deep Brain Stimulation on Intertemporal Decision-Making in Parkinson Patients123

    PubMed Central

    Wojtecki, Lars; Storzer, Lena; Schnitzler, Alfons

    2016-01-01

    Abstract Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a widely used treatment for the motor symptoms of Parkinson’s disease (PD). DBS or pharmacological treatment is believed to modulate the tendency to, or reverse, impulse control disorders. Several brain areas involved in impulsivity and reward valuation, such as the prefrontal cortex and striatum, are linked to the STN, and activity in these areas might be affected by STN-DBS. To investigate the effect of STN-DBS on one type of impulsive decision-making—delay discounting (i.e., the devaluation of reward with increasing delay until its receipt)—we tested 40 human PD patients receiving STN-DBS treatment and medication for at least 3 months. Patients were pseudo-randomly assigned to one of four groups to test the effects of DBS on/off states as well as medication on/off states on delay discounting. The delay-discounting task consisted of a series of choices among a smaller. sooner or a larger, later monetary reward. Despite considerable effects of DBS on motor performance, patients receiving STN-DBS did not choose more or less impulsively compared with those in the off-DBS group, as well as when controlling for risk attitude. Although null results have to be interpreted with caution, our findings are of significance to other researchers studying the effects of PD treatment on impulsive decision-making, and they are of clinical relevance for determining the therapeutic benefits of using STN-DBS. PMID:27257622

  19. Optimizing Vetoes for Gravitational-wave Transient Searches

    NASA Technical Reports Server (NTRS)

    Essick, R.; Blackburn, Lindy L.; Katsavounidis, E.

    2014-01-01

    Interferometric gravitational-wave detectors like LIGO, GEO600 and Virgo record a surplus of information above and beyond possible gravitational-wave events. These auxiliary channels capture information about the state of the detector and its surroundings which can be used to infer potential terrestrial noise sources of some gravitational-wave-like events. We present an algorithm addressing the ordering (or equivalently optimizing) of such information from auxiliary systems in gravitational-wave detectors to establish veto conditions in searches for gravitational-wave transients. The procedure was used to identify vetoes for searches for unmodelled transients by the LIGO and Virgo collaborations during their science runs from 2005 through 2007. In this work we present the details of the algorithm; we also use a limited amount of data from LIGO's past runs in order to examine the method, compare it with other methods, and identify its potential to characterize the instruments themselves. We examine the dependence of Receiver Operating Characteristic curves on the various parameters of the veto method and the implementation on real data. We find that the method robustly determines important auxiliary channels, ordering them by the apparent strength of their correlations to the gravitational-wave channel. This list can substantially reduce the background of noise events in the gravitational-wave data. In this way it can identify the source of glitches in the detector as well as assist in establishing confidence in the detection of gravitational-wave transients.

  20. Rogue waves and entropy consumption

    NASA Astrophysics Data System (ADS)

    Hadjihoseini, Ali; Lind, Pedro G.; Mori, Nobuhito; Hoffmann, Norbert P.; Peinke, Joachim

    2017-11-01

    Based on data from the Sea of Japan and the North Sea the occurrence of rogue waves is analyzed by a scale-dependent stochastic approach, which interlinks fluctuations of waves for different spacings. With this approach we are able to determine a stochastic cascade process, which provides information of the general multipoint statistics. Furthermore the evolution of single trajectories in scale, which characterize wave height fluctuations in the surroundings of a chosen location, can be determined. The explicit knowledge of the stochastic process enables to assign entropy values to all wave events. We show that for these entropies the integral fluctuation theorem, a basic law of non-equilibrium thermodynamics, is valid. This implies that positive and negative entropy events must occur. Extreme events like rogue waves are characterized as negative entropy events. The statistics of these entropy fluctuations changes with the wave state, thus for the Sea of Japan the statistics of the entropies has a more pronounced tail for negative entropy values, indicating a higher probability of rogue waves.

  1. Deep brain stimulation modulates synchrony within spatially and spectrally distinct resting state networks in Parkinson's disease.

    PubMed

    Oswal, Ashwini; Beudel, Martijn; Zrinzo, Ludvic; Limousin, Patricia; Hariz, Marwan; Foltynie, Tom; Litvak, Vladimir; Brown, Peter

    2016-05-01

    Chronic dopamine depletion in Parkinson's disease leads to progressive motor and cognitive impairment, which is associated with the emergence of characteristic patterns of synchronous oscillatory activity within cortico-basal-ganglia circuits. Deep brain stimulation of the subthalamic nucleus is an effective treatment for Parkinson's disease, but its influence on synchronous activity in cortico-basal-ganglia loops remains to be fully characterized. Here, we demonstrate that deep brain stimulation selectively suppresses certain spatially and spectrally segregated resting state subthalamic nucleus-cortical networks. To this end we used a validated and novel approach for performing simultaneous recordings of the subthalamic nucleus and cortex using magnetoencephalography (during concurrent subthalamic nucleus deep brain stimulation). Our results highlight that clinically effective subthalamic nucleus deep brain stimulation suppresses synchrony locally within the subthalamic nucleus in the low beta oscillatory range and furthermore that the degree of this suppression correlates with clinical motor improvement. Moreover, deep brain stimulation relatively selectively suppressed synchronization of activity between the subthalamic nucleus and mesial premotor regions, including the supplementary motor areas. These mesial premotor regions were predominantly coupled to the subthalamic nucleus in the high beta frequency range, but the degree of deep brain stimulation-associated suppression in their coupling to the subthalamic nucleus was not found to correlate with motor improvement. Beta band coupling between the subthalamic nucleus and lateral motor areas was not influenced by deep brain stimulation. Motor cortical coupling with subthalamic nucleus predominantly involved driving of the subthalamic nucleus, with those drives in the higher beta frequency band having much shorter net delays to subthalamic nucleus than those in the lower beta band. These observations raise the

  2. Cerenkov emissions of ion acoustic-like waves generated by electron beams emitted during TSS 1R

    NASA Astrophysics Data System (ADS)

    Huang, C. Y.; Burke, W. J.; Hardy, D. A.; Gough, M. P.; Olson, D. G.; Gentile, L. C.; Gilchrist, B. E.; Bonifazi, C.; Raitt, W. J.; Thompson, D. C.

    During the Tethered Satellite System reflight the Spacecraft Particle Correlation Experiment detected fluxes of energetic electrons and ions that were simultaneously modulated at low frequencies during firings of both the fast pulsed electron gun (FPEG) and the electron generator assembly (EGA). The modulations have been interpreted as signatures of large-amplitude, ion acoustic-like waves excited in Cerenkov interactions between electron beams and ambient plasmas as the shuttle moved at supersonic speeds across the ionospheric magnetic field. We present examples of particle modulations observed during steady beam emissions. Measurements show that (1) most electron modulations were at frequencies of several hundred Hertz and (2) ions modulated at similar frequencies appeared at spectral energy peaks during shuttle negative charging events. Detection of modulated ion fluxes confirms the Cerenkov emission hypothesis. Observed frequency variations indicate that the EGA beam underwent more spatial spreading than the FPEG beam.

  3. Excitation of plane Lamb wave in plate-like structures under applied surface loading

    NASA Astrophysics Data System (ADS)

    Zhou, Kai; Xu, Xinsheng; Zhao, Zhen; Yang, Zhengyan; Zhou, Zhenhuan; Wu, Zhanjun

    2018-02-01

    Lamb waves play an important role in structure health monitoring (SHM) systems. The excitation of Lamb waves has been discussed for a long time with absorbing results. However, little effort has been made towards the precise characterization of Lamb wave excitation by various transducer models with mathematical foundation. In this paper, the excitation of plane Lamb waves with plane strain assumption in isotropic plate structures under applied surface loading is solved with the Hamiltonian system. The response of the Lamb modes excited by applied loading is expressed analytically. The effect of applied loading is divided into the product of two parts as the effect of direction and the effect of distribution, which can be changed by selecting different types of transducer and the corresponding transducer configurations. The direction of loading determines the corresponding displacement of each mode. The effect of applied loading on the in-plane and normal directions depends on the in-plane and normal displacements at the surface respectively. The effect of the surface loading distribution on the Lamb mode amplitudes is mainly reflected by amplitude versus frequency or wavenumber. The frequencies at which the maxima and minima of the S0 or A0 mode response occur depend on the distribution of surface loading. The numerical results of simulations conducted on an infinite aluminum plate verify the theoretical prediction of not only the direction but also the distribution of applied loading. A pure S0 or A0 mode can be excited by selecting the appropriate direction and distribution at the corresponding frequency.

  4. Relativistic nonlinear plasma waves in a magnetic field

    NASA Technical Reports Server (NTRS)

    Kennel, C. F.; Pellat, R.

    1975-01-01

    Five relativistic plane nonlinear waves were investigated: circularly polarized waves and electrostatic plasma oscillations propagating parallel to the magnetic field, relativistic Alfven waves, linearly polarized transverse waves propagating in zero magnetic field, and the relativistic analog of the extraordinary mode propagating at an arbitrary angle to the magnetic field. When the ions are driven relativistic, they behave like electrons, and the assumption of an 'electron-positron' plasma leads to equations which have the form of a one-dimensional potential well. The solutions indicate that a large-amplitude superluminous wave determines the average plasma properties.

  5. Lagrangian methods in nonlinear plasma wave interaction

    NASA Technical Reports Server (NTRS)

    Crawford, F. W.

    1980-01-01

    Analysis of nonlinear plasma wave interactions is usually very complicated, and simplifying mathematical approaches are highly desirable. The application of averaged-Lagrangian methods offers a considerable reduction in effort, with improved insight into synchronism and conservation (Manley-Rowe) relations. This chapter indicates how suitable Lagrangian densities have been defined, expanded, and manipulated to describe nonlinear wave-wave and wave-particle interactions in the microscopic, macroscopic and cold plasma models. Recently, further simplifications have been introduced by the use of techniques derived from Lie algebra. These and likely future developments are reviewed briefly.

  6. Atmospheric-like rotating annulus experiment: gravity wave emission from baroclinic jets

    NASA Astrophysics Data System (ADS)

    Rodda, Costanza; Borcia, Ion; Harlander, Uwe

    2017-04-01

    Large-scale balanced flows can spontaneously radiate meso-scale inertia-gravity waves (IGWs) and are thus in fact unbalanced. While flow-dependent parameterizations for the radiation of IGWs from orographic and convective sources do exist, the situation is less developed for spontaneously emitted IGWs. Observations identify increased IGW activity in the vicinity of jet exit regions. A direct interpretation of those based on geostrophic adjustment might be tempting. However, directly applying this concept to the parameterization of spontaneous imbalance is difficult since the dynamics itself is continuously re-establishing an unbalanced flow which then sheds imbalances by GW radiation. Examining spontaneous IGW emission in the atmosphere and validating parameterization schemes confronts the scientist with particular challenges. Due to its extreme complexity, GW emission will always be embedded in the interaction of a multitude of interdependent processes, many of which are hardly detectable from analysis or campaign data. The benefits of repeated and more detailed measurements, while representing the only source of information about the real atmosphere, are limited by the non-repeatability of an atmospheric situation. The same event never occurs twice. This argues for complementary laboratory experiments, which can provide a more focused dialogue between experiment and theory. Indeed, life cycles are also examined in rotating- annulus laboratory experiments. Thus, these experiments might form a useful empirical benchmark for theoretical and modelling work that is also independent of any sort of subgrid model. In addition, the more direct correspondence between experimental and model data and the data reproducibility makes lab experiments a powerful testbed for parameterizations. Joint laboratory experiment and numerical simulation have been conducted. The comparison between the data obtained from the experiment and the numerical simulations shows a very good

  7. Role of equatorial waves in tropical cyclogenesis

    NASA Astrophysics Data System (ADS)

    Schreck, Carl J., III

    Tropical cyclones typically form within preexisting wavelike disturbances that couple with convection. Using Tropical Rainfall Measuring Mission (TRMM) multisatellite rainfall estimates, this study determines the relative number of tropical cyclones that can be attributed to various wave types, including the Madden--Julian oscillation (MJO), Kelvin waves, equatorial Rossby (ER) waves, mixed Rossby--gravity (MRG) waves, and tropical depression (TD)-type disturbances. Tropical cyclogenesis is attributed to an equatorial wave's convection when the filtered rainfall anomaly exceeds a threshold value at the genesis location. More storms are attributed to TD-type disturbances than to any other wave type in all of the Northern Hemisphere basins. In the Southern Hemisphere, however, ER waves and TD-type disturbances are equally important as precursors. Fewer storms are attributed to MRG waves, Kelvin waves, and the MJO in every basin. Although relatively few storms are attributed to the MJO, tropical cyclogenesis is 2.6 times more likely in its convective phase compared with its suppressed phase. This modulation arises in part because each equatorial wave type is amplified within MJO's convective phase. The amplification significantly increases the probability that these waves will act as tropical cyclone precursors. A case study from June 2002 illustrates the effects of a series of Kelvin waves on two tropical cyclone formations. These waves were embedded in the convective phase of the MJO. Together, the MJO and the Kelvin waves preconditioned the low-level environment for cyclogenesis. The first Kelvin wave weakened the trade easterlies, while the subsequent waves created monsoon westerlies near the equator. These westerlies provided the background cyclonic vorticity within which both storms developed. The effects of tropical cyclone-related rainfall anomalies are also investigated. In the wavenumber--frequency spectrum for rainfall, tropical cyclones can inflate the

  8. Radial wave crystals: radially periodic structures from anisotropic metamaterials for engineering acoustic or electromagnetic waves.

    PubMed

    Torrent, Daniel; Sánchez-Dehesa, José

    2009-08-07

    We demonstrate that metamaterials with anisotropic properties can be used to develop a new class of periodic structures that has been named radial wave crystals. They can be sonic or photonic, and wave propagation along the radial directions is obtained through Bloch states like in usual sonic or photonic crystals. The band structure of the proposed structures can be tailored in a large amount to get exciting novel wave phenomena. For example, it is shown that acoustical cavities based on radial sonic crystals can be employed as passive devices for beam forming or dynamically orientated antennas for sound localization.

  9. The photon: Experimental emphasis on its wave-particle duality

    NASA Technical Reports Server (NTRS)

    Shih, Yan-Hua; Sergienko, A. V.; Rubin, Morton H.; Kiess, Thomas E.; Alley, Carroll O.

    1994-01-01

    Two types of Einstein-Podolsky-Rosen experiments were demonstrated recently in our laboratory. It is interesting to see that in an interference experiment (wave-like experiment) the photon exhibits its particle property, and in a beam-splitting experiment (particle-like experiment) the photon exhibits its wave property. The two-photon states are produced from Type 1 and Type 2 optical spontaneous parametric down conversion, respectively.

  10. Sound Radiated by a Wave-Like Structure in a Compressible Jet

    NASA Technical Reports Server (NTRS)

    Golubev, V. V.; Prieto, A. F.; Mankbadi, R. R.; Dahl, M. D.; Hixon, R.

    2003-01-01

    This paper extends the analysis of acoustic radiation from the source model representing spatially-growing instability waves in a round jet at high speeds. Compared to previous work, a modified approach to the sound source modeling is examined that employs a set of solutions to linearized Euler equations. The sound radiation is then calculated using an integral surface method.

  11. Electromagnetic waves in a topological insulator thin film stack: helicon-like wave mode and photonic band structure.

    PubMed

    Inoue, Jun-ichi

    2013-09-09

    We theoretically explore the electromagnetic modes specific to a topological insulator superlattice in which topological and conventional insulator thin films are stacked periodically. In particular, we obtain analytic formulas for low energy mode that corresponds to a helicon wave, as well as those for photonic bands. We illustrate that the system can be modeled as a stack of quantum Hall layers whose conductivity tensors alternately change signs, and then we analyze the photonic band structures. This subject is a natural extension of a previous study by Tselis et al., which took into consideration a stack of identical quantum Hall layers but their discussion was limited into a low energy mode. Thus we provide analytic formulas for photonic bands and compare their features between the two systems. Our central findings in the topological insulator superlattice are that a low energy mode corresponding to a helicon wave has linear dispersion instead of the conventional quadratic form, and that a robust gapless photonic band appears although the system considered has spacial periodicity. In addition, we demonstrate that the photonic bands agree with the numerically calculated transmission spectra.

  12. Angular-spectrum representation of nondiffracting X waves

    NASA Astrophysics Data System (ADS)

    Fagerholm, Juha; Friberg, Ari T.; Huttunen, Juhani; Morgan, David P.; Salomaa, Martti M.

    1996-10-01

    We derive the nondiffracting X waves, first discussed within acoustics by Lu and Greenleaf [IEEE Trans. Ultrason. Ferroelec. Freq. Contr. 39, 19 (1992)], using the general mathematical formalism based on an angular spectrum of plane waves. This serves to provide a unified treatment of not only the fundamental zeroth-order X waves of Lu and Greenleaf, but also of the lesser-known higher-order derivative X waves, first discussed here in terms of a single, universal, angular spectrum. The characteristic crossed (letter-X-like) shape and the special properties of the X waves, as well as of their angular-spectrum representation, are discussed and illustrated in detail. Asymptotically, for increasing order, the appearance of the X waves is found to transform into a triangular wedgelike waveform.

  13. Mechanism of phase control in a klystron-like relativistic backward wave oscillator by an input signal

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xiao, Renzhen; Song, Zhimin; Deng, Yuqun

    Theoretical analyses and particle-in-cell (PIC) simulations are carried out to understand the mechanism of microwave phase control realized by the external RF signal in a klystron-like relativistic backward wave oscillator (RBWO). Theoretical calculations show that a modulated electron beam can lead the microwave field with an arbitrary initial phase to the same equilibrium phase, which is determined by the phase factor of the modulated current, and the difference between them is fixed. Furthermore, PIC simulations demonstrate that the phase of input signal has a close relation to that of modulated current, which initiates the phase of the irregularly microwave duringmore » the build-up of oscillation. Since the microwave field is weak during the early time of starting oscillation, it is easy to be induced, and a small input signal is sufficient to control the phase of output microwave. For the klystron-like RBWO with two pre-modulation cavities and a reentrant input cavity, an input signal with 100 kW power and 4.21 GHz frequency can control the phase of 5 GW output microwave with relative phase difference less than 6% when the diode voltage is 760 kV, and beam current is 9.8 kA, corresponding to a power ratio of output microwave to input signal of 47 dB.« less

  14. Modeling elastic wave propagation in kidney stones with application to shock wave lithotripsy.

    PubMed

    Cleveland, Robin O; Sapozhnikov, Oleg A

    2005-10-01

    A time-domain finite-difference solution to the equations of linear elasticity was used to model the propagation of lithotripsy waves in kidney stones. The model was used to determine the loading on the stone (principal stresses and strains and maximum shear stresses and strains) due to the impact of lithotripsy shock waves. The simulations show that the peak loading induced in kidney stones is generated by constructive interference from shear waves launched from the outer edge of the stone with other waves in the stone. Notably the shear wave induced loads were significantly larger than the loads generated by the classic Hopkinson or spall effect. For simulations where the diameter of the focal spot of the lithotripter was smaller than that of the stone the loading decreased by more than 50%. The constructive interference was also sensitive to shock rise time and it was found that the peak tensile stress reduced by 30% as rise time increased from 25 to 150 ns. These results demonstrate that shear waves likely play a critical role in stone comminution and that lithotripters with large focal widths and short rise times should be effective at generating high stresses inside kidney stones.

  15. Magnetic Black Hole Waves

    NASA Image and Video Library

    2015-07-09

    This cartoon shows how magnetic waves, called Alfvén S-waves, propagate outward from the base of black hole jets. The jet is a flow of charged particles, called a plasma, which is launched by a black hole. The jet has a helical magnetic field (yellow coil) permeating the plasma. The waves then travel along the jet, in the direction of the plasma flow, but at a velocity determined by both the jet's magnetic properties and the plasma flow speed. The BL Lac jet examined in a new study is several light-years long, and the wave speed is about 98 percent the speed of light. Fast-moving magnetic waves emanating from a distant supermassive black hole undulate like a whip whose handle is being shaken by a giant hand, according to a study using data from the National Radio Astronomy Observatory's Very Long Baseline Array. Scientists used this instrument to explore the galaxy/black hole system known as BL Lacertae (BL Lac) in high resolution. http://photojournal.jpl.nasa.gov/catalog/PIA19822

  16. Effects of climate change on wave height at the coast

    NASA Astrophysics Data System (ADS)

    Wolf, J.

    2003-04-01

    To make progress towards the ultimate objective of predicting coastal vulnerability to climate change, we need to predict the probability of extreme values of sea level and wave height, and their likely variation with changing climate. There is evidence of changes in sea level and wave height on various time-scales. For example, the North Atlantic Oscillation appears to be responsible for increasing wave height in the North Atlantic over recent decades. The impact of changes in wave height in the North Atlantic at the coastline in the North Sea, the Hebrides/Malin Shelf and the English Channel will be quite different. Three different, and contrasting areas are examined The effect of changing sea levels, due to global warming and changes in tides and surge height and frequency, is combined with increases in offshore wave height. Coastal wave modelling, using the WAM and SWAN wave models, provides a useful tool for examining the possible impacts of climate change at the coast. This study is part of a Tyndall Centre project which is examining the vulnerability of the UK coast to changing wave climate and sea level. These changes are likely to be especially important in low-lying areas with coastal wetlands such as the north Norfolk coast, which has been selected as a detailed case study area. In this area there are offshore shallow banks and extensive inter-tidal areas. There are transitions from upper marsh to freshwater grazing marshes, sand dunes, shingle beaches, mudflats and sandflats. Many internationally important and varied habitats are threatened by rising sea levels and changes in storminess due to potential climate change effects. Likely changes in overtopping of coastal embankments, inundation of intertidal areas, sediment transport and coastal erosion are examined. Changes in low water level may be important as well as high water. The second area of study is Christchurch Bay in the English Channel. The English Channel is exposed to swell from the North

  17. Possible management of near shore nonlinear surging waves through bottom boundary conditions

    NASA Astrophysics Data System (ADS)

    Mukherjee, Abhik; Janaki, M. S.; Kundu, Anjan

    2017-03-01

    We propose an alternative way for managing near shore surging waves, including extreme waves like tsunamis, going beyond the conventional passive measures like the warning system. We study theoretically the possibility of influencing the nonlinear surface waves through a leakage boundary effect at the bottom. It has been found through analytic result, that the controlled leakage at the bottom might regulate the amplitude of the surface solitary waves. This could lead to a possible decay of the surging waves to reduce its hazardous effects near the shore. Our theoretical results are estimated by applying it to a real coastal bathymetry of the Bay of Bengal in India.

  18. Plasma waves in the magnetic hole

    NASA Technical Reports Server (NTRS)

    Lin, Naiguo; Kellogg, P. J.; MacDowall, R.; Balogh, A.; Forsyth, R. J.; Phillips, J. L.; Pick, M.

    1995-01-01

    Magnetic holes in the solar wind, which are characterized by isolated local depressions in the magnetic field magnitude, have been observed previously. The Unified Radio and Plasma Wave (URAP) instrument of Ulysses has found that within such magnetic structures, electrostatic waves at kHz frequency and ultralow frequency electromagnetic waves are often excited and seen as short duration wave bursts. Most of these bursts occur near the ambient electron plasma frequency, which suggests that the waves are Langmuir waves. Such waves are usually excited by electron streams. Some evidence of the streaming of energetic electrons required for exciting Langmuir waves has been observed. These electrons may have originated at sources near the Sun, which would imply that the magnetic structures containing the waves would exist as long channels formed by field and plasma conditions near the Sun. On the other hand, the electrons could be suprathermal 'tails' from wave collapse processes occurring near the spacecraft. In either case, the Langmuir waves excited in the magnetic holes provide a measurement of the plasma density inside the holes. Low frequency electromagnetic waves, having frequencies of a fraction of the local electron cyclotron frequency, sometimes accompany the Langmuir waves observed in magnetic holes. Waves excited in this frequency range are very likely to be whistler-mode waves. They may have been excited by an electron temperature anisotropy which has been observed in the vicinity of the magnetic holes or generated through the decay of Langmuir waves.

  19. SH wave structure of the crust and upper mantle in southeastern margin of the Tibetan Plateau from teleseismic Love wave tomography

    NASA Astrophysics Data System (ADS)

    Fu, Yuanyuan V.; Jia, Ruizhi; Han, Fengqin; Chen, Anguo

    2018-06-01

    The deep structure of southeastern Tibet is important for determining lateral plateau expansion mechanisms, such as movement of rigid crustal blocks along large strike-slip faults, continuous deformation or the eastward crustal channel flow. We invert for 3-D isotropic SH wave velocity model of the crust and upper mantle to the depth of 110 km from Love wave phase velocity data using a best fitting average model as the starting model. The 3-D SH velocity model presented here is the first SH wave velocity structure in the study area. In the model, the Tibetan Plateau is characterized by prominent slow SH wave velocity with channel-like geometry along strike-slip faults in the upper crust and as broad zones in the lower crust, indicating block-like and distributed deformation at different depth. Positive radial anisotropy (VSH > VSV) is suggested by a high SH wave and low SV wave anomaly at the depths of 70-110 km beneath the northern Indochina block. This positive radial anisotropy could result from the horizontal alignment of anisotropic minerals caused by lithospheric extensional deformation due to the slab rollback of the Australian plate beneath the Sumatra trench.

  20. Broadband Metamaterial for Nonresonant Matching of Acoustic Waves

    DTIC Science & Technology

    2012-03-28

    35898, USA. Unity transmittance at an interface between bulk media is quite common for polarized electromagnetic waves incident at the Brewster angle ...metamaterial possessing a Brewster -like angle that is completely transparent to sound waves over an ultra-broadband frequency range with .100% bandwidth...Unity transmittance at an interface between bulk media is quite common for polarized electromagnetic waves incident at the Brewster angle , but it is

  1. Principles of Space Plasma Wave Instrument Design

    NASA Technical Reports Server (NTRS)

    Gurnett, Donald A.

    1998-01-01

    Space plasma waves span the frequency range from somewhat below the ion cyclotron frequency to well above the electron cyclotron frequency and plasma frequency. Because of the large frequency range involved, the design of space plasma wave instrumentation presents many interesting challenges. This chapter discusses the principles of space plasma wave instrument design. The topics covered include: performance requirements, electric antennas, magnetic antennas, and signal processing. Where appropriate, comments are made on the likely direction of future developments.

  2. Semiannual Status Report. [excitation of electromagnetic waves in the whistler frequency range

    NASA Technical Reports Server (NTRS)

    1994-01-01

    During the last six months, we have continued our study of the excitation of electromagnetic waves in the whistler frequency range and the role that these waves will play in the acceleration of electrons and ions in the auroral region. A paper entitled 'Electron Beam Excitation of Upstream Waves in the Whistler Mode Frequency Range' was listed in the Journal of Geophysical Research. In this paper, we have shown that an anisotropic electron beam (or gyrating electron beam) is capable of generating both left-hand and right-hand polarized electromagnetic waves in the whistler frequency range. Since right-hand polarized electromagnetic waves can interact with background electrons and left-hand polarized waves can interact with background ions through cyclotron resonance, it is possible that these beam generated left-hand and right-hand polarized electromagnetic waves can accelerate either ions or electrons (or both), depending on the physical parameters under consideration. We are currently carrying out a comprehensive study of the electromagnetic whistler and lower hybrid like waves observed in the auroral zone using both wave and particle data. Our first task is to identify these wave modes and compare it with particle observations. Using both the DE-1 particle and wave measurements, we can positively identify those electromagnetics lower hybrid like waves as fast magnetosonic waves and the upper cutoff of these waves is the local lower hybrid frequency. From the upper cutoff of the frequency spectrum, one can infer the particle density and the result is in very good agreement with the particle data. Since these electromagnetic lower hybrid like waves can have frequencies extended down to the local ion cyclotron frequency, it practically confirms that they are not whistler waves.

  3. Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease

    PubMed Central

    Wu, Xi; Qiu, Yiqing; Simfukwe, Keith; Wang, Jiali; Chen, Jianchun

    2017-01-01

    Background Stimulation-induced transient nonmotor psychiatric symptoms (STPSs) are side effects following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients. We designed algorithms which (1) determine the electrode contacts that induce STPSs and (2) provide a programming protocol to eliminate STPS and maintain the optimal motor functions. Our objective is to test the effectiveness of these algorithms. Materials and Methods 454 PD patients who underwent programming sessions after STN-DBS implantations were retrospectively analyzed. Only STPS patients were enrolled. In these patients, the contacts inducing STPS were found and the programming protocol algorithms used. Results Eleven patients were diagnosed with STPS. Of these patients, two had four episodes of crying, and two had four episodes of mirthful laughter. In one patient, two episodes of abnormal sense of spatial orientation were observed. Hallucination episodes were observed twice in one patient, while five patients recorded eight episodes of hypomania. There were no statistical differences between the UPDRS-III under the final stimulation parameter (without STPS) and previous optimum UPDRS-III under the STPSs (p = 1.000). Conclusion The flow diagram used for determining electrode contacts that induce STPS and the programming protocol employed in the treatment of these symptoms are effective. PMID:28894620

  4. Neuronal Responses in the Globus Pallidus during Subthalamic Nucleus Electrical Stimulation in Normal and Parkinson's Disease Model Rats

    PubMed Central

    Ryu, Sang Baek; Bae, Eun Kyung; Kim, Jinhyung; Hwang, Yong Sup; Im, Changkyun; Chang, Jin Woo; Shin, Hyung-Cheul

    2013-01-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been widely used as a treatment for the movement disturbances caused by Parkinson's disease (PD). Despite successful application of DBS, its mechanism of therapeutic effect is not clearly understood. Because PD results from the degeneration of dopamine neurons that affect the basal ganglia (BG) network, investigation of neuronal responses of BG neurons during STN DBS can provide informative insights for the understanding of the mechanism of therapeutic effect. However, it is difficult to observe neuronal activity during DBS because of large stimulation artifacts. Here, we report the observation of neuronal activities of the globus pallidus (GP) in normal and PD model rats during electrical stimulation of the STN. A custom artifact removal technique was devised to enable monitoring of neural activity during stimulation. We investigated how GP neurons responded to STN stimulation at various stimulation frequencies (10, 50, 90 and 130 Hz). It was observed that activities of GP neurons were modulated by stimulation frequency of the STN and significantly inhibited by high frequency stimulation above 50 Hz. These findings suggest that GP neuronal activity is effectively modulated by STN stimulation and strongly dependent on the frequency of stimulation. PMID:23946689

  5. Modeling transversely isotropic, viscoelastic, incompressible tissue-like materials with application in ultrasound shear wave elastography

    NASA Astrophysics Data System (ADS)

    Qiang, Bo; Brigham, John C.; Aristizabal, Sara; Greenleaf, James F.; Zhang, Xiaoming; Urban, Matthew W.

    2015-02-01

    In this paper, we propose a method to model the shear wave propagation in transversely isotropic, viscoelastic and incompressible media. The targeted application is ultrasound-based shear wave elastography for viscoelasticity measurements in anisotropic tissues such as the kidney and skeletal muscles. The proposed model predicts that if the viscoelastic parameters both across and along fiber directions can be characterized as a Voigt material, then the spatial phase velocity at any angle is also governed by a Voigt material model. Further, with the aid of Taylor expansions, it is shown that the spatial group velocity at any angle is close to a Voigt type for weakly attenuative materials within a certain bandwidth. The model is implemented in a finite element code by a time domain explicit integration scheme and shear wave simulations are conducted. The results of the simulations are analyzed to extract the shear wave elasticity and viscosity for both the spatial phase and group velocities. The estimated values match well with theoretical predictions. The proposed theory is further verified by an ex vivo tissue experiment measured in a porcine skeletal muscle by an ultrasound shear wave elastography method. The applicability of the Taylor expansion to analyze the spatial velocities is also discussed. We demonstrate that the approximations from the Taylor expansions are subject to errors when the viscosities across or along the fiber directions are large or the maximum frequency considered is beyond the bandwidth defined by radii of convergence of the Taylor expansions.

  6. Large-Amplitude High-Frequency Waves at Earth's Magnetopause

    NASA Astrophysics Data System (ADS)

    Graham, D. B.; Vaivads, A.; Khotyaintsev, Yu. V.; André, M.; Le Contel, O.; Malaspina, D. M.; Lindqvist, P.-A.; Wilder, F. D.; Ergun, R. E.; Gershman, D. J.; Giles, B. L.; Magnes, W.; Russell, C. T.; Burch, J. L.; Torbert, R. B.

    2018-04-01

    Large-amplitude waves near the electron plasma frequency are found by the Magnetospheric Multiscale (MMS) mission near Earth's magnetopause. The waves are identified as Langmuir and upper hybrid (UH) waves, with wave vectors either close to parallel or close to perpendicular to the background magnetic field. The waves are found all along the magnetopause equatorial plane, including both flanks and close to the subsolar point. The waves reach very large amplitudes, up to 1 V m-1, and are thus among the most intense electric fields observed at Earth's magnetopause. In the magnetosphere and on the magnetospheric side of the magnetopause the waves are predominantly UH waves although Langmuir waves are also found. When the plasma is very weakly magnetized only Langmuir waves are likely to be found. Both Langmuir and UH waves are shown to have electromagnetic components, which are consistent with predictions from kinetic wave theory. These results show that the magnetopause and magnetosphere are often unstable to intense wave activity near the electron plasma frequency. These waves provide a possible source of radio emission at the magnetopause.

  7. Harmonic effects on ion-bulk waves and simulation of stimulated ion-bulk-wave scattering in CH plasmas

    NASA Astrophysics Data System (ADS)

    Feng, Q. S.; Zheng, C. Y.; Liu, Z. J.; Cao, L. H.; Xiao, C. Z.; Wang, Q.; Zhang, H. C.; He, X. T.

    2017-08-01

    Ion-bulk (IBk) wave, a novel branch with a phase velocity close to the ion’s thermal velocity, discovered by Valentini et al (2011 Plasma Phys. Control. Fusion 53 105017), is recently considered as an important electrostatic activity in solar wind, and thus of great interest to space physics and also inertial confinement fusion. The harmonic effects on IBk waves has been researched by Vlasov simulation for the first time. The condition of excitation of the large-amplitude IBk waves is given. The nature of nonlinear IBk waves in the condition of k< {k}{{lor}}/2 (k lor is the wave number at loss-of-resonance point) is undamped Bernstein-Greene-Kruskal-like waves with harmonic superposition. Only when the wave number k of IBk waves satisfies {k}{{lor}}/2≲ k≤slant {k}{{lor}}, can a large-amplitude and mono-frequency IBk wave be excited. A novel stimulated scattering from IBk modes called stimulated ion-bulk-wave scattering (SIBS) or stimulated Feng scattering (SFS) has been proposed and also verified by Vlasov-Maxwell code. In CH plasmas, in addition to the stimulated Brillouin scattering from multi ion-acoustic waves, there exists SIBS simultaneously. This research gives an insight into the SIBS in the field of laser plasma interaction.

  8. A midsummer-night's shock wave

    NASA Astrophysics Data System (ADS)

    Hargather, Michael; Liebner, Thomas; Settles, Gary

    2007-11-01

    The aerial pyrotechnic shells used in professional display fireworks explode a bursting charge at altitude in order to disperse the ``stars'' of the display. The shock wave from the bursting charge is heard on the ground as a loud report, though it has by then typically decayed to a mere sound wave. However, viewers seated near the standard safety borders can still be subjected to weak shock waves. These have been visualized using a large, portable, retro-reflective ``Edgerton'' shadowgraph technique and a high-speed digital video camera. Images recorded at 10,000 frames per second show essentially-planar shock waves from 10- and 15-cm firework shells impinging on viewers during the 2007 Central Pennsylvania July 4th Festival. The shock speed is not measurably above Mach 1, but we nonetheless conclude that, if one can sense a shock-like overpressure, then the wave motion is strong enough to be observed by density-sensitive optics.

  9. Oscillatory subthalamic nucleus activity is modulated by dopamine during emotional processing in Parkinson's disease.

    PubMed

    Huebl, Julius; Spitzer, Bernhard; Brücke, Christof; Schönecker, Thomas; Kupsch, Andreas; Alesch, François; Schneider, Gerd-Helge; Kühn, Andrea A

    2014-11-01

    Dopaminergic denervation in Parkinson's disease (PD) leads to motor deficits but also depression, lack of motivation and apathy. These symptoms can be reversed by dopaminergic treatment, which may even lead to an increased hedonic tone in some patients with PD. Here, we tested the effects of dopamine on emotional processing as indexed by changes in local field potential (LFP) activity of the subthalamic nucleus (STN) in 28 PD patients undergoing deep brain stimulation. LFP activity from the STN was recorded after the administration of levodopa (ON group) or after overnight withdrawal of medication (OFF group) during presentation of an emotional picture-viewing task. Neutral and emotionally arousing pleasant and unpleasant stimuli were chosen from the International Affective Picture System. We found a double dissociation of the alpha band response depending on dopamine state and stimulus valence: dopamine enhanced the processing of pleasant stimuli, while activation during unpleasant stimuli was reduced, as indexed by the degree of desynchronization in the alpha frequency band. This pattern was reversed in the OFF state and more pronounced in the subgroup of non-depressed PD patients. Further, we found an early gamma band increase with unpleasant stimuli that occurred when ON but not OFF medication and was correlated with stimulus arousal. The late STN alpha band decrease is thought to represent active processing of sensory information. Our findings support the idea that dopamine enhances approach-related processes during late stimulus evaluation in PD. The early gamma band response may represent local encoding of increased attention, which varies as a function of stimulus arousal. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Tako-tsubo-like syndrome, a case report.

    PubMed

    Patanè, Salvatore; Marte, Filippo

    2008-02-29

    Tako-tsubo-like (Japanese word for octopus-catcher) left ventricular dysfunction is an enigmatic cardiomyopathy. Typically, the patients have a history of recent stressful incidents immediately preceding onset of mild to moderate chest pain, have ST-segment elevation in leads V3 through V6, ECG changes that typically demonstrate diffuse T-wave inversions and abnormal QS-wave development, discrete wall motion abnormalities involving the lower anterior wall and apex on echocardiography or left ventriculography, and limited myocardial enzyme release without evidence for hemodynamically significant coronary arterial stenoses by angiography. We describe a case of a Tako-tsubo-like left ventricular dysfunction in a 72-year-old female Italian woman.

  11. Several localized waves induced by linear interference between a nonlinear plane wave and bright solitons

    NASA Astrophysics Data System (ADS)

    Qin, Yan-Hong; Zhao, Li-Chen; Yang, Zhan-Ying; Yang, Wen-Li

    2018-01-01

    We investigate linear interference effects between a nonlinear plane wave and bright solitons, which are admitted by a pair-transition coupled two-component Bose-Einstein condensate. We demonstrate that the interference effects can induce several localized waves possessing distinctive wave structures, mainly including anti-dark solitons, W-shaped solitons, multi-peak solitons, Kuznetsov-Ma like breathers, and multi-peak breathers. Specifically, the explicit conditions for them are clarified by a phase diagram based on the linear interference properties. Furthermore, the interactions between these localized waves are discussed. The detailed analysis indicates that the soliton-soliton interaction induced phase shift brings the collision between these localized waves which can be inelastic for solitons involving collision and can be elastic for breathers. These characters come from the fact that the profile of solitons depends on the relative phase between bright solitons and a plane wave, and the profile of breathers does not depend on the relative phase. These results would motivate more discussions on linear interference between other nonlinear waves. Specifically, the solitons or breathers obtained here are not related to modulational instability. The underlying reasons are discussed in detail. In addition, possibilities to observe these localized waves are discussed in a two species Bose-Einstein condensate.

  12. [Effects of bilateral deep brain stimulation in the subthalamic nucleus using two methods of target structure verification].

    PubMed

    Goubareva, N N; Fedorova, N V; Bril', E V; Tomskiy, A A; Gamaleya, A A; Poddubskaya, A A; Shabalov, V A; Omarova, S M

    To evaluate the efficacy of deep brain stimulation in the subthalamic nucleus (DBS STN) in patients with Parkinson's disease (PD) using different methods of targeting according to the dynamics of motor symptoms of PD. The study involved 90 patients treated with DBS STN. In 30 cases intraoperative microelectrode recording (MER) was used. MER was not performed in 30 patients of the comparison group. The control group consisted of 30 patients with PD who received conservative treatment. Hoehn and Yahr scale, Tinetti Balance and Mobility Scale (TBMS), Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Quality of Life-39 Scoring System (РDQ-39), Schwab & England ADL Scale were used. Levodopa equivalent daily dose (LEDD, 2010) was calculated for each patient. The effect of DBS STN using intraoperative microelectrode recording on the main motor symptoms, motor complications, walking as well as indicators of quality of life and daily activities was shown. In both DBS STN groups, there was a significant reduction in the LEDD and marked improvement of the control of motor symptoms of PD. A significant reduction in the severity of motor fluctuations (50%) and drug-induced dyskinesia (51%) was observed. Quality of life and daily activity in off-medication condition were significantly improved in both DBS STN groups of patients, irrespective of the method of target planning (75-100%), compared with the control group.

  13. Generation of Highly Oblique Lower Band Chorus Via Nonlinear Three-Wave Resonance

    DOE PAGES

    Fu, Xiangrong; Gary, Stephen Peter; Reeves, Geoffrey D.; ...

    2017-09-05

    Chorus in the inner magnetosphere has been observed frequently at geomagnetically active times, typically exhibiting a two-band structure with a quasi-parallel lower band and an upper band with a broad range of wave normal angles. But recent observations by Van Allen Probes confirm another type of lower band chorus, which has a large wave normal angle close to the resonance cone angle. It has been proposed that these waves could be generated by a low-energy beam-like electron component or by temperature anisotropy of keV electrons in the presence of a low-energy plateau-like electron component. This paper, however, presents an alternativemore » mechanism for generation of this highly oblique lower band chorus. Through a nonlinear three-wave resonance, a quasi-parallel lower band chorus wave can interact with a mildly oblique upper band chorus wave, producing a highly oblique quasi-electrostatic lower band chorus wave. This theoretical analysis is confirmed by 2-D electromagnetic particle-in-cell simulations. Furthermore, as the newly generated waves propagate away from the equator, their wave normal angle can further increase and they are able to scatter low-energy electrons to form a plateau-like structure in the parallel velocity distribution. As a result, the three-wave resonance mechanism may also explain the generation of quasi-parallel upper band chorus which has also been observed in the magnetosphere.« less

  14. Effects of subthalamic stimulation on speech of consecutive patients with Parkinson disease

    PubMed Central

    Zrinzo, L.; Martinez-Torres, I.; Frost, E.; Pinto, S.; Foltynie, T.; Holl, E.; Petersen, E.; Roughton, M.; Hariz, M.I.; Limousin, P.

    2011-01-01

    Objective: Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for advanced Parkinson disease (PD). Following STN-DBS, speech intelligibility can deteriorate, limiting its beneficial effect. Here we prospectively examined the short- and long-term speech response to STN-DBS in a consecutive series of patients to identify clinical and surgical factors associated with speech change. Methods: Thirty-two consecutive patients were assessed before surgery, then 1 month, 6 months, and 1 year after STN-DBS in 4 conditions on- and off-medication with on- and off-stimulation using established and validated speech and movement scales. Fifteen of these patients were followed up for 3 years. A control group of 12 patients with PD were followed up for 1 year. Results: Within the surgical group, speech intelligibility significantly deteriorated by an average of 14.2% ± 20.15% off-medication and 16.9% ± 21.8% on-medication 1 year after STN-DBS. The medical group deteriorated by 3.6% ± 5.5% and 4.5% ± 8.8%, respectively. Seven patients showed speech amelioration after surgery. Loudness increased significantly in all tasks with stimulation. A less severe preoperative on-medication motor score was associated with a more favorable speech response to STN-DBS after 1 year. Medially located electrodes on the left STN were associated with a significantly higher risk of speech deterioration than electrodes within the nucleus. There was a strong relationship between high voltage in the left electrode and poor speech outcome at 1 year. Conclusion: The effect of STN-DBS on speech is variable and multifactorial, with most patients exhibiting decline of speech intelligibility. Both medical and surgical issues contribute to deterioration of speech in STN-DBS patients. Classification of evidence: This study provides Class III evidence that STN-DBS for PD results in deterioration in speech intelligibility in all combinations of medication and stimulation states at 1

  15. Analysis of sediment particle velocity in wave motion based on wave flume experiments

    NASA Astrophysics Data System (ADS)

    Krupiński, Adam

    2012-10-01

    The experiment described was one of the elements of research into sediment transport conducted by the Division of Geotechnics of West-Pomeranian University of Technology. The experimental analyses were performed within the framework of the project "Building a knowledge transfer network on the directions and perspectives of developing wave laboratory and in situ research using innovative research equipment" launched by the Institute of Hydroengineering of the Polish Academy of Sciences in Gdańsk. The objective of the experiment was to determine relations between sediment transport and wave motion parameters and then use the obtained results to modify formulas defining sediment transport in rivers, like Ackers-White formula, by introducing basic parameters of wave motion as the force generating bed material transport. The article presents selected results of the experiment concerning sediment velocity field analysis conducted for different parameters of wave motion. The velocity vectors of particles suspended in water were measured with a Particle Image Velocimetry (PIV) apparatus registering suspended particles in a measurement flume by producing a series of laser pulses and analysing their displacement with a high-sensitivity camera connected to a computer. The article presents velocity fields of suspended bed material particles measured in the longitudinal section of the wave flume and their comparison with water velocity profiles calculated for the definite wave parameters. The results presented will be used in further research for relating parameters essential for the description of monochromatic wave motion to basic sediment transport parameters and "transforming" mean velocity and dynamic velocity in steady motion to mean wave front velocity and dynamic velocity in wave motion for a single wave.

  16. Non-plane-wave Hartree-Fock states and nuclear homework potentials

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gutierrez, G.; Plastino, A.; de Llano, M.

    1979-12-01

    It is shown that non-plane-wave single-particle Hartree-Fock orbitals giving rise to a ''spin-density-wave-like'' structure give lower energy than plane waves beyond a certain relatively low density in both nuclear and neutron matter with homework pair potentials v/sub 1/ and v/sub 2/.

  17. Nonlinear wave particle interaction in the Earth's foreshock

    NASA Technical Reports Server (NTRS)

    Mazelle, C.; LeQueau, D.; Meziane, K.; Lin, R. P.; Parks, G.; Reme, H.; Sanderson, T.; Lepping, R. P.

    1997-01-01

    The possibility that ion beams could provide a free energy source for driving an ion/ion instability responsible for the ULF wave occurrence is investigated. For this, the wave dispersion relation with the observed parameters is solved. Secondly, it is shown that the ring-like distributions could then be produced by a coherent nonlinear wave-particle interaction. It tends to trap the ions into narrow cells in velocity space centered around a well-defined pitch-angle, directly related to the saturation wave amplitude in the analytical theory. The theoretical predictions with the observations are compared.

  18. Extending RTM Imaging With a Focus on Head Waves

    NASA Astrophysics Data System (ADS)

    Holicki, Max; Drijkoningen, Guy

    2016-04-01

    Conventional industry seismic imaging predominantly focuses on pre-critical reflections, muting post-critical arrivals in the process. This standard approach neglects a lot of information present in the recorded wave field. This negligence has been partially remedied with the inclusion of head waves in more advanced imaging techniques, like Full Waveform Inversion (FWI). We would like to see post-critical information leave the realm of labour-intensive travel-time picking and tomographic inversion towards full migration to improve subsurface imaging and parameter estimation. We present a novel seismic imaging approach aimed at exploiting post-critical information, using the constant travel path for head-waves between shots. To this end, we propose to generalize conventional Reverse Time Migration (RTM) to scenarios where the sources for the forward and backward propagated wave-fields are not coinciding. RTM functions on the principle that backward propagated receiver data, due to a source at some locations, must overlap with the forward propagated source wave field, from the same source location, at subsurface scatterers. Where the wave-fields overlap in the subsurface there is a peak at the zero-lag cross-correlation, and this peak is used for the imaging. For the inclusion of head waves, we propose to relax the condition of coincident sources. This means that wave-fields, from non-coincident-sources, will not overlap properly in the subsurface anymore. We can make the wave-fields overlap in the subsurface again, by time shifting either the forward or backward propagated wave-fields until the wave-fields overlap. This is the same as imaging at non-zero cross-correlation lags, where the lag is the travel time difference between the two wave-fields for a given event. This allows us to steer which arrivals we would like to use for imaging. In the simplest case we could use Eikonal travel-times to generate our migration image, or we exclusively image the subsurface

  19. Parametric instabilities of finite-amplitude, circularly polarized Alfven waves in an anisotropic plasma

    NASA Technical Reports Server (NTRS)

    Hamabata, Hiromitsu

    1993-01-01

    A class of parametric instabilities of finite-amplitude, circularly polarized Alfven waves in a plasma with pressure anisotropy is studied by application of the CGL equations. A linear perturbation analysis is used to find the dispersion relation governing the instabilities, which is a fifth-order polynomial and is solved numerically. A large-amplitude, circularly polarized wave is unstable with respect to decay into three waves: one sound-like wave and two side-band Alfven-like waves. It is found that, in addition to the decay instability, two new instabilities that are absent in the framework of the MHD equations can occur, depending on the plasma parameters.

  20. Effects of deep brain stimulation of the subthalamic nucleus on inhibitory and executive control over prepotent responses in Parkinson's disease

    PubMed Central

    Jahanshahi, Marjan

    2013-01-01

    Inhibition of inappropriate, habitual or prepotent responses is an essential component of executive control and a cornerstone of self-control. Via the hyperdirect pathway, the subthalamic nucleus (STN) receives inputs from frontal areas involved in inhibition and executive control. Evidence is reviewed from our own work and the literature suggesting that in Parkinson's disease (PD), deep brain stimulation (DBS) of the STN has an impact on executive control during attention-demanding tasks or in situations of conflict when habitual or prepotent responses have to be inhibited. These results support a role for the STN in an inter-related set of processes: switching from automatic to controlled processing, inhibitory and executive control, adjusting response thresholds and influencing speed-accuracy trade-offs. Such STN DBS-induced deficits in inhibitory and executive control may contribute to some of the psychiatric problems experienced by a proportion of operated cases after STN DBS surgery in PD. However, as no direct evidence for such a link is currently available, there is a need to provide direct evidence for such a link between STN DBS-induced deficits in inhibitory and executive control and post-surgical psychiatric complications experienced by operated patients. PMID:24399941

  1. Gravitational Waves and Time Domain Astronomy

    NASA Technical Reports Server (NTRS)

    Centrella, Joan; Nissanke, Samaya; Williams, Roy

    2012-01-01

    The gravitational wave window onto the universe will open in roughly five years, when Advanced LIGO and Virgo achieve the first detections of high frequency gravitational waves, most likely coming from compact binary mergers. Electromagnetic follow-up of these triggers, using radio, optical, and high energy telescopes, promises exciting opportunities in multi-messenger time domain astronomy. In the decade, space-based observations of low frequency gravitational waves from massive black hole mergers, and their electromagnetic counterparts, will open up further vistas for discovery. This two-part workshop featured brief presentations and stimulating discussions on the challenges and opportunities presented by gravitational wave astronomy. Highlights from the workshop, with the emphasis on strategies for electromagnetic follow-up, are presented in this report.

  2. Gravitational Waves: A New Observational Window

    NASA Technical Reports Server (NTRS)

    Camp, Jordan B.

    2010-01-01

    The era of gravitational wave astronomy is rapidly approaching, with a likely start date around the middle of this decade ' Gravitational waves, emitted by accelerated motions of very massive objects, provide detailed information about strong-field gravity and its sources, including black holes and neutron stars, that electromagnetic probes cannot access. In this talk I will discuss the anticipated sources and the status of the extremely sensitive detectors (both ground and space based) that will make gravitational wave detections possible. As ground based detectors are now taking data, I will show some initial science results related to measured upper limits on gravitational wave signals. Finally Z will describe new directions including advanced detectors and joint efforts with other fields of astronomy.

  3. Near-field tsunami edge waves and complex earthquake rupture

    USGS Publications Warehouse

    Geist, Eric L.

    2013-01-01

    The effect of distributed coseismic slip on progressive, near-field edge waves is examined for continental shelf tsunamis. Detailed observations of edge waves are difficult to separate from the other tsunami phases that are observed on tide gauge records. In this study, analytic methods are used to compute tsunami edge waves distributed over a finite number of modes and for uniformly sloping bathymetry. Coseismic displacements from static elastic theory are introduced as initial conditions in calculating the evolution of progressive edge-waves. Both simple crack representations (constant stress drop) and stochastic slip models (heterogeneous stress drop) are tested on a fault with geometry similar to that of the M w = 8.8 2010 Chile earthquake. Crack-like ruptures that are beneath or that span the shoreline result in similar longshore patterns of maximum edge-wave amplitude. Ruptures located farther offshore result in reduced edge-wave excitation, consistent with previous studies. Introduction of stress-drop heterogeneity by way of stochastic slip models results in significantly more variability in longshore edge-wave patterns compared to crack-like ruptures for the same offshore source position. In some cases, regions of high slip that are spatially distinct will yield sub-events, in terms of tsunami generation. Constructive interference of both non-trapped and trapped waves can yield significantly larger tsunamis than those that produced by simple earthquake characterizations.

  4. Type IIB Colliding Plane Waves

    NASA Astrophysics Data System (ADS)

    Gutperle, M.; Pioline, B.

    2003-09-01

    Four-dimensional colliding plane wave (CPW) solutions have played an important role in understanding the classical non-linearities of Einstein's equations. In this note, we investigate CPW solutions in 2n+2-dimensional Einstein gravity with a n+1-form flux. By using an isomorphism with the four-dimensional problem, we construct exact solutions analogous to the Szekeres vacuum solution in four dimensions. The higher-dimensional versions of the Khan-Penrose and Bell-Szekeres CPW solutions are studied perturbatively in the vicinity of the light-cone. We find that under small perturbations, a curvature singularity is generically produced, leading to both space-like and time-like singularities. For n = 4, our results pertain to the collision of two ten-dimensional type-IIB Blau-Figueroa o'Farrill-Hull-Papadopoulos plane waves.

  5. Laboratory modeling of edge wave generation over a plane beach by breaking waves

    NASA Astrophysics Data System (ADS)

    Abcha, Nizar; Ezersky, Alexander; Pelinovsky, Efim

    2015-04-01

    Edge waves play an important role in coastal hydrodynamics: in sediment transport, in formation of coastline structure and coastal bottom topography. Investigation of physical mechanisms leading to the edge waves generation allows us to determine their effect on the characteristics of spatially periodic patterns like crescent submarine bars and cusps observed in the coastal zone. In the present paper we investigate parametric excitation of edge wave with frequency two times less than the frequency of surface wave propagating perpendicular to the beach. Such mechanism of edge wave generation has been studied previously in a large number of papers using the assumption of non-breaking waves. This assumption was used in theoretical calculations and such conditions were created in laboratory experiments. In the natural conditions, the wave breaking is typical when edge waves are generated at sea beach. We study features of such processes in laboratory experiments. Experiments were performed in the wave flume of the Laboratory of Continental and Coast Morphodynamics (M2C), Caen. The flume is equipment with a wave maker controlled by computer. To model a plane beach, a PVC plate is placed at small angle to the horizontal bottom. Several resistive probes were used to measure characteristics of waves: one of them was used to measure free surface displacement near the wave maker and two probes were glued on the inclined plate. These probes allowed us to measure run-up due to parametrically excited edge waves. Run-up height is determined by processing a movie shot by high-speed camera. Sub-harmonic generation of standing edge waves is observed for definite control parameters: edge waves represent themselves a spatial mode with wavelength equal to double width of the flume; the frequency of edge wave is equal to half of surface wave frequency. Appearance of sub-harmonic mode instability is studied using probes and movie processing. The dependence of edge wave exponential

  6. On the physics of waves in the solar atmosphere: Wave heating and wind acceleration

    NASA Technical Reports Server (NTRS)

    Musielak, Z. E.

    1994-01-01

    New calculations of the acoustic wave energy fluxes generated in the solar convective zone have been performed. The treatment of convective turbulence in the sun and solar-like stars, in particular, the precise nature of the turbulent power spectrum has been recognized as one of the most important issues in the wave generation problem. Several different functional forms for spatial and temporal spectra have been considered in the literature and differences between the energy fluxes obtained for different forms often exceed two orders of magnitude. The basic criterion for choosing the appropriate spectrum was the maximal efficiency of the wave generation. We have used a different approach based on physical and empirical arguments as well as on some results from numerical simulation of turbulent convection.

  7. Proper source-receiver distance to obtain surface wave group velocity profile for flaw detection inside a concrete plate-like structure

    NASA Astrophysics Data System (ADS)

    Cheng, Chia-Chi; Hsu, Keng-Tsang; Wang, Hong-Hua; Chiang, Chih-Hung

    2018-04-01

    A technique leads to rapid flaw detection for concrete plate-like structure is realized by obtaining the group velocity dispersion profile of the fundamental antisymmetric mode of the plate (A0 mode). The depth of a delaminating crack, honeycomb or depth of weak surface layer on top of the sound concrete can all be evaluated by the change of velocity in the dispersion profile of A0 mode at the wavelength about twice of the depth. The testing method involves obtaining the A0 group slowness spectrogram produced by single test with one receiver placed away from the source of impact. The image of the spectrogram is obtained by Short-Time Fourier Transfer (STFT) and enhanced by reassigned method. The choice of window length in STFT and the ratio between impactor-receiver distance and plate thickness, d/T, is essential as the dominant surface wave response may simply a non-dispersive Rayleigh wave or following the A0 or S0 (fundamental symmetric mode) modal dispersion curve. In this study, the axisymmetric finite element model of a plate subject to transient load was constructed. The nodal vertical velocity waveforms for various distances were analyzed using various STFT window lengths. The results show, for certain d/T ratio, S0 mode would be dominant when longer window is used. The best window lengths for a d/T ratio as well as the corresponding largest wavelength which follows the A0 theoretical dispersion curve or Rayleigh wave were summarized. The information allows people to determine the proper impactor-receiver distance and analyzing window to successfully detect the depth of flaws inside a plate.

  8. Orbital phase dependent IUE spectra of the nova like binary II Arietis

    NASA Technical Reports Server (NTRS)

    Guinan, E. F.; Sion, E. M.

    1981-01-01

    Nine low dispersion IUE spectra of the nova like binary TT Ari over its 3h17m orbital period were obtained. Four short wave spectra and five long wave spectra exhibit marked changes in line strength and continuum shape with orbital phase. The short wave spectra show the presence in absorption of C III, Lyman alpha, SiIII, NV, SiIV, CIV, HeII, AlIII, and NIV. The CIV shows a P Cygni profile on two of the spectra. Implications of these spectra for the nature of nova like variables are discussed.

  9. The effect of unilateral electrostimulation of the subthalamic nucleus on respiratory/phonatory subsystems of speech production in Parkinson's disease--a preliminary report.

    PubMed

    Wang, Emily; Verhagen Metman, Leo; Bakay, Roy; Arzbaecher, Jean; Bernard, Bryan

    2003-01-01

    This paper reports findings on the respiratory/phonatory subsystems from an on-going study investigating the effect of unilateral electrostimulation of the subthalamic nucleus (STN) on different speech subsystems in people with Parkinson's disease (PD). Speech recordings were made in the medication-off state at baseline, three months post surgery with stimulation-on, and with stimulation-off, in six right-handed PD patients. Subjects completed several speech tasks. Acoustic analyses of the maximally sustained vowel phonation were reported. The results were compared to the scores of the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS-III) obtained under the same conditions. Results showed that stimulation-on improved UPDRS-III scores in all six subjects. While mild improvement was observed for all subjects in the Stimulation-on condition, three subjects received left-STN stimulation showed a significant decline in vocal intensity and vowel duration from their baseline indicating the speech function was very susceptible to micro lesions due to the surgical procedure itself when the surgical site was in the dominant hemisphere.

  10. Asymptotic analysis of numerical wave propagation in finite difference equations

    NASA Technical Reports Server (NTRS)

    Giles, M.; Thompkins, W. T., Jr.

    1983-01-01

    An asymptotic technique is developed for analyzing the propagation and dissipation of wave-like solutions to finite difference equations. It is shown that for each fixed complex frequency there are usually several wave solutions with different wavenumbers and the slowly varying amplitude of each satisfies an asymptotic amplitude equation which includes the effects of smoothly varying coefficients in the finite difference equations. The local group velocity appears in this equation as the velocity of convection of the amplitude. Asymptotic boundary conditions coupling the amplitudes of the different wave solutions are also derived. A wavepacket theory is developed which predicts the motion, and interaction at boundaries, of wavepackets, wave-like disturbances of finite length. Comparison with numerical experiments demonstrates the success and limitations of the theory. Finally an asymptotic global stability analysis is developed.

  11. Global Hybrid Simulation of Alfvenic Waves Associated with Magnetotail Reconnection and Fast Flows

    NASA Astrophysics Data System (ADS)

    Cheng, L.; Lin, Y.; Wang, X.; Perez, J. D.

    2017-12-01

    Alfvenic fluctuations have been observed near the magnetotail plasma sheet boundary layer associated with fast flows. In this presentation, we use the Auburn 3-D Global Hybrid code (ANGIE3D) to investigate the generation and propagation of Alfvenic waves in the magnetotail. Shear Alfven waves and kinetic Alfven waves (KAWs) are found to be generated in magnetic reconnection in the plasma sheet as well as in the dipole-like field region of the magnetosphere, carrying Poynting flux along magnetic field lines toward the ionosphere, and the wave structure is strongly altered by the flow braking in the tail. The 3-D structure of the wave electromagnetic field and the associated parallel currents in reconnection and the dipole-like field region is presented. The Alfvenic waves exhibit a turbulence spectrum. The roles of these Alfvenic waves in ion heating is discussed.

  12. Gravitational-wave astronomy: delivering on the promises

    NASA Astrophysics Data System (ADS)

    Schutz, B. F.

    2018-05-01

    Now that LIGO and Virgo have begun to detect gravitational-wave events with regularity, the field of gravitational-wave astronomy is beginning to realize its promise. Binary black holes and, very recently, binary neutron stars have been observed, and we are already learning much from them. The future, with improved sensitivity, more detectors and detectors like LISA in different frequency bands, has even more promise to open a completely hidden side of the Universe to our exploration. This article is part of a discussion meeting issue `The promises of gravitational-wave astronomy'.

  13. Application of interface waves for near surface damage detection in hybrid structures

    NASA Astrophysics Data System (ADS)

    Jahanbin, M.; Santhanam, S.; Ihn, J.-B.; Cox, A.

    2017-04-01

    Guided waves are acoustic waves that are guided by boundaries. Depending on the structural geometry, guided waves can either propagate between boundaries, known as plate waves, or propagate on the surface of the objects. Many different types of surface waves exist based on the material property of the boundary. For example Rayleigh wave in solid - air, Scholte wave in solid - liquid, Stoneley in solid - solid interface and many other different forms like Love wave on inhomogeneous surfaces, creeping waves, etc. This research work is demonstrating the application of surface and interface waves for detection of interfacial damages in hybrid bonded structures.

  14. Global Intracellular Slow-Wave Dynamics of the Thalamocortical System

    PubMed Central

    Sheroziya, Maxim

    2014-01-01

    It is widely accepted that corticothalamic neurons recruit the thalamus in slow oscillation, but global slow-wave thalamocortical dynamics have never been experimentally shown. We analyzed intracellular activities of neurons either from different cortical areas or from a variety of specific and nonspecific thalamic nuclei in relation to the phase of global EEG signal in ketamine-xylazine anesthetized mice. We found that, on average, slow-wave active states started off within frontal cortical areas as well as higher-order and intralaminar thalamus (posterior and parafascicular nuclei) simultaneously. Then, the leading edge of active states propagated in the anteroposterior/lateral direction over the cortex at ∼40 mm/s. The latest structure we recorded within the slow-wave cycle was the anterior thalamus, which followed active states of the retrosplenial cortex. Active states from different cortical areas tended to terminate simultaneously. Sensory thalamic ventral posterior medial and lateral geniculate nuclei followed cortical active states with major inhibitory and weak tonic-like “modulator” EPSPs. In these nuclei, sharp-rising, large-amplitude EPSPs (“drivers”) were not modulated by cortical slow waves, suggesting their origin in ascending pathways. The thalamic active states in other investigated nuclei were composed of depolarization: some revealing “driver”- and “modulator”-like EPSPs, others showing “modulator”-like EPSPs only. We conclude that sensory thalamic nuclei follow the propagating cortical waves, whereas neurons from higher-order thalamic nuclei display “hub dynamics” and thus may contribute to the generation of cortical slow waves. PMID:24966387

  15. Novel PEPA-functionalized graphene oxide for fire safety enhancement of polypropylene

    PubMed Central

    Xu, Jia You; Liu, Jie; Li, Kai Dan; Tanemura, Sakae

    2015-01-01

    Polypropylene (PP) is a general-purpose plastic, but some applications are constrained by its high flammability. Thus, flame retardant PP is urgently demanded. In this article, intumescent flame retardant PP (IFRPP) composites with enhanced fire safety were prepared using 1-oxo-4-hydroxymethyl-2,6,7-trioxa-1-phosphabicyclo [2.2.2] octane (PEPA) functionalized graphene oxide (PGO) as synergist. The PGO was prepared through a mild chemical reaction by the covalent attachment of a caged-structure organic compound, PEPA, onto GO nanosheets using toluene diisocynate (TDI) as the intermediary agent. The novel PEPA-functionalized graphene oxide not only improves the heat resistance of GO but also converts GO and PEPA from hydrophobic to hydrophilic materials, which leads to even distribution in PP. In our case, 7 wt% addition of PGO as one of the fillers for IFRPP composites significantly reduces its inflammability and fire hazards when compared with PEPA, by the improvement of first release rate peak (PHRR), total heat release, first smoke release rate peak (PSRR) and total smoke release, suggesting its great potential as the IFR synergist in industry. The reason is mainly attributed to the barrier effect of the unburned graphene sheets, which protects by the decomposition products of PEPA and TDI, promotes the formation of graphitized carbon and inhibits the heat and gas release. PMID:27877775

  16. Novel PEPA-functionalized graphene oxide for fire safety enhancement of polypropylene

    NASA Astrophysics Data System (ADS)

    You Xu, Jia; Liu, Jie; Li, Kai Dan; Miao, Lei; Tanemura, Sakae

    2015-04-01

    Polypropylene (PP) is a general-purpose plastic, but some applications are constrained by its high flammability. Thus, flame retardant PP is urgently demanded. In this article, intumescent flame retardant PP (IFRPP) composites with enhanced fire safety were prepared using 1-oxo-4-hydroxymethyl-2,6,7-trioxa-1-phosphabicyclo [2.2.2] octane (PEPA) functionalized graphene oxide (PGO) as synergist. The PGO was prepared through a mild chemical reaction by the covalent attachment of a caged-structure organic compound, PEPA, onto GO nanosheets using toluene diisocynate (TDI) as the intermediary agent. The novel PEPA-functionalized graphene oxide not only improves the heat resistance of GO but also converts GO and PEPA from hydrophobic to hydrophilic materials, which leads to even distribution in PP. In our case, 7 wt% addition of PGO as one of the fillers for IFRPP composites significantly reduces its inflammability and fire hazards when compared with PEPA, by the improvement of first release rate peak (PHRR), total heat release, first smoke release rate peak (PSRR) and total smoke release, suggesting its great potential as the IFR synergist in industry. The reason is mainly attributed to the barrier effect of the unburned graphene sheets, which protects by the decomposition products of PEPA and TDI, promotes the formation of graphitized carbon and inhibits the heat and gas release.

  17. Wave propagation of spectral energy content in a granular chain

    NASA Astrophysics Data System (ADS)

    Shrivastava, Rohit Kumar; Luding, Stefan

    2017-06-01

    A mechanical wave is propagation of vibration with transfer of energy and momentum. Understanding the spectral energy characteristics of a propagating wave through disordered granular media can assist in understanding the overall properties of wave propagation through inhomogeneous materials like soil. The study of these properties is aimed at modeling wave propagation for oil, mineral or gas exploration (seismic prospecting) or non-destructive testing of the internal structure of solids. The focus is on the total energy content of a pulse propagating through an idealized one-dimensional discrete particle system like a mass disordered granular chain, which allows understanding the energy attenuation due to disorder since it isolates the longitudinal P-wave from shear or rotational modes. It is observed from the signal that stronger disorder leads to faster attenuation of the signal. An ordered granular chain exhibits ballistic propagation of energy whereas, a disordered granular chain exhibits more diffusive like propagation, which eventually becomes localized at long time periods. For obtaining mean-field macroscopic/continuum properties, ensemble averaging has been used, however, such an ensemble averaged spectral energy response does not resolve multiple scattering, leading to loss of information, indicating the need for a different framework for micro-macro averaging.

  18. Analysis of the Giacobini-Zinner bow wave

    NASA Technical Reports Server (NTRS)

    Smith, E. J.; Slavin, J. A.; Bame, S. J.; Thomsen, M. F.; Cowley, S. W. H.; Richardson, I. G.; Hovestadt, D.; Ipavich, F. M.; Ogilvie, K. W.; Coplan, M. A.

    1986-01-01

    The cometary bow wave of P/Giacobini-Zinner has been analyzed using the complete set of ICE field and particle observations to determine if it is a shock. Changes in the magnetic field and plasma flow velocities from upstream to downstream have been analyzed to determine the direction of the normal and the propagation velocity of the bow wave. The velocity has then been compared with the fast magnetosonic wave speed upstream to derive the Mach number and establish whether it is supersonic, i.e., a shock, or subsonic, i.e., a large amplitude wave. The various measurements have also been compared with values derived from a Rankine-Hugoniot analysis. The results indicate that, inbound, the bow wave is a shock with M = 1.5. Outbound, a subsonic Mach number is obtained, however, arguments are presented that the bow wave is also likely to be a shock at this location.

  19. Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo.

    PubMed

    González-Rueda, Ana; Pedrosa, Victor; Feord, Rachael C; Clopath, Claudia; Paulsen, Ole

    2018-03-21

    Activity-dependent synaptic plasticity is critical for cortical circuit refinement. The synaptic homeostasis hypothesis suggests that synaptic connections are strengthened during wake and downscaled during sleep; however, it is not obvious how the same plasticity rules could explain both outcomes. Using whole-cell recordings and optogenetic stimulation of presynaptic input in urethane-anesthetized mice, which exhibit slow-wave-sleep (SWS)-like activity, we show that synaptic plasticity rules are gated by cortical dynamics in vivo. While Down states support conventional spike timing-dependent plasticity, Up states are biased toward depression such that presynaptic stimulation alone leads to synaptic depression, while connections contributing to postsynaptic spiking are protected against this synaptic weakening. We find that this novel activity-dependent and input-specific downscaling mechanism has two important computational advantages: (1) improved signal-to-noise ratio, and (2) preservation of previously stored information. Thus, these synaptic plasticity rules provide an attractive mechanism for SWS-related synaptic downscaling and circuit refinement. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

  20. Synchronism of nonlinear internal waves in a three-layer fluid

    NASA Astrophysics Data System (ADS)

    Talipova, Tatiana; Kurkina, Oxana; Terletska, Katerina; Rouvinskaya, Ekaterina

    2017-04-01

    In a three layer fluid with arbitrary layer widths and densities the existence of long internal solitons and breathers is proven theoretically and numerically, see for example (Pelinovsky et al., 2007; Lamb et al., 2007). The existence of breather-like waves of the intermediate length is also shown in numerical simulations (Terletska et al., 2016). For such waves conditions of synchronism are valid when a breather of the first mode and a soliton of the second mode move together with the same speed and form an asymmetric solitary wave of the second mode. The process of strong interaction of long nonlinear internal waves in the framework of three-layer Camassa-Choi model demonstrates the same effect (Jo&Choi, 2014; Barros, 2016). We analyze possible synchronism conditions for steady-state internal waves in a three-layer fluid analytically the framework of the Gardner equation, which is valid for long weakly nonlinear internal waves. The equations for synchronism conditions are derived and considered in terms of wave amplitudes, layer widths and density jumps. The configurations of three-layer fluid are found for which such a synchronism is possible. References: Barros R. Large amplitude internal waves in three-layer flows. The forth international conference "Nonlinear Waves - Theory and Applications", MS7, Beijing, China, June 25 - 28, 2016 Pelinovsky E., Polukhina O., Slunyaev A., Talipova T. Internal solitary waves // Chapter 4 in the book "Solitary Waves in Fluids". WIT Press. Southampton, Boston. 2007. P. 85 - 110. K. Terletska., K. T. Jung, T. Talipova, V. Maderich, I. Brovchenko and R. Grimshaw Internal breather-like wave generation by the second mode solitary wave interaction with a step// Physics of Fluids, 2016, accepted

  1. Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus.

    PubMed

    Bot, Maarten; Schuurman, P Richard; Odekerken, Vincent J J; Verhagen, Rens; Contarino, Fiorella Maria; De Bie, Rob M A; van den Munckhof, Pepijn

    2018-05-01

    Individual motor improvement after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) varies considerably. Stereotactic targeting of the dorsolateral sensorimotor part of the STN is considered paramount for maximising effectiveness, but studies employing the midcommissural point (MCP) as anatomical reference failed to show correlation between DBS location and motor improvement. The medial border of the STN as reference may provide better insight in the relationship between DBS location and clinical outcome. Motor improvement after 12 months of 65 STN DBS electrodes was categorised into non-responding, responding and optimally responding body-sides. Stereotactic coordinates of optimal electrode contacts relative to both medial STN border and MCP served to define theoretic DBS 'hotspots'. Using the medial STN border as reference, significant negative correlation (Pearson's correlation -0.52, P<0.01) was found between the Euclidean distance from the centre of stimulation to this DBS hotspot and motor improvement. This hotspot was located at 2.8 mm lateral, 1.7 mm anterior and 2.5 mm superior relative to the medial STN border. Using MCP as reference, no correlation was found. The medial STN border proved superior compared with MCP as anatomical reference for correlation of DBS location and motor improvement, and enabled defining an optimal DBS location within the nucleus. We therefore propose the medial STN border as a better individual reference point than the currently used MCP on preoperative stereotactic imaging, in order to obtain optimal and thus less variable motor improvement for individual patients with PD following STN DBS. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  2. Nonlinear ultrasonic imaging with X wave

    NASA Astrophysics Data System (ADS)

    Du, Hongwei; Lu, Wei; Feng, Huanqing

    2009-10-01

    X wave has a large depth of field and may have important application in ultrasonic imaging to provide high frame rate (HFR). However, the HFR system suffers from lower spatial resolution. In this paper, a study of nonlinear imaging with X wave is presented to improve the resolution. A theoretical description of realizable nonlinear X wave is reported. The nonlinear field is simulated by solving the KZK nonlinear wave equation with a time-domain difference method. The results show that the second harmonic field of X wave has narrower mainlobe and lower sidelobes than the fundamental field. In order to evaluate the imaging effect with X wave, an imaging model involving numerical calculation of the KZK equation, Rayleigh-Sommerfeld integral, band-pass filtering and envelope detection is constructed to obtain 2D fundamental and second harmonic images of scatters in tissue-like medium. The results indicate that if X wave is used, the harmonic image has higher spatial resolution throughout the entire imaging region than the fundamental image, but higher sidelobes occur as compared to conventional focus imaging. A HFR imaging method with higher spatial resolution is thus feasible provided an apodization method is used to suppress sidelobes.

  3. Catching the right wave: evaluating wave energy resources and potential compatibility with existing marine and coastal uses.

    PubMed

    Kim, Choong-Ki; Toft, Jodie E; Papenfus, Michael; Verutes, Gregory; Guerry, Anne D; Ruckelshaus, Marry H; Arkema, Katie K; Guannel, Gregory; Wood, Spencer A; Bernhardt, Joanna R; Tallis, Heather; Plummer, Mark L; Halpern, Benjamin S; Pinsky, Malin L; Beck, Michael W; Chan, Francis; Chan, Kai M A; Levin, Phil S; Polasky, Stephen

    2012-01-01

    Many hope that ocean waves will be a source for clean, safe, reliable and affordable energy, yet wave energy conversion facilities may affect marine ecosystems through a variety of mechanisms, including competition with other human uses. We developed a decision-support tool to assist siting wave energy facilities, which allows the user to balance the need for profitability of the facilities with the need to minimize conflicts with other ocean uses. Our wave energy model quantifies harvestable wave energy and evaluates the net present value (NPV) of a wave energy facility based on a capital investment analysis. The model has a flexible framework and can be easily applied to wave energy projects at local, regional, and global scales. We applied the model and compatibility analysis on the west coast of Vancouver Island, British Columbia, Canada to provide information for ongoing marine spatial planning, including potential wave energy projects. In particular, we conducted a spatial overlap analysis with a variety of existing uses and ecological characteristics, and a quantitative compatibility analysis with commercial fisheries data. We found that wave power and harvestable wave energy gradually increase offshore as wave conditions intensify. However, areas with high economic potential for wave energy facilities were closer to cable landing points because of the cost of bringing energy ashore and thus in nearshore areas that support a number of different human uses. We show that the maximum combined economic benefit from wave energy and other uses is likely to be realized if wave energy facilities are sited in areas that maximize wave energy NPV and minimize conflict with existing ocean uses. Our tools will help decision-makers explore alternative locations for wave energy facilities by mapping expected wave energy NPV and helping to identify sites that provide maximal returns yet avoid spatial competition with existing ocean uses.

  4. Catching the Right Wave: Evaluating Wave Energy Resources and Potential Compatibility with Existing Marine and Coastal Uses

    PubMed Central

    Kim, Choong-Ki; Toft, Jodie E.; Papenfus, Michael; Verutes, Gregory; Guerry, Anne D.; Ruckelshaus, Marry H.; Arkema, Katie K.; Guannel, Gregory; Wood, Spencer A.; Bernhardt, Joanna R.; Tallis, Heather; Plummer, Mark L.; Halpern, Benjamin S.; Pinsky, Malin L.; Beck, Michael W.; Chan, Francis; Chan, Kai M. A.; Levin, Phil S.; Polasky, Stephen

    2012-01-01

    Many hope that ocean waves will be a source for clean, safe, reliable and affordable energy, yet wave energy conversion facilities may affect marine ecosystems through a variety of mechanisms, including competition with other human uses. We developed a decision-support tool to assist siting wave energy facilities, which allows the user to balance the need for profitability of the facilities with the need to minimize conflicts with other ocean uses. Our wave energy model quantifies harvestable wave energy and evaluates the net present value (NPV) of a wave energy facility based on a capital investment analysis. The model has a flexible framework and can be easily applied to wave energy projects at local, regional, and global scales. We applied the model and compatibility analysis on the west coast of Vancouver Island, British Columbia, Canada to provide information for ongoing marine spatial planning, including potential wave energy projects. In particular, we conducted a spatial overlap analysis with a variety of existing uses and ecological characteristics, and a quantitative compatibility analysis with commercial fisheries data. We found that wave power and harvestable wave energy gradually increase offshore as wave conditions intensify. However, areas with high economic potential for wave energy facilities were closer to cable landing points because of the cost of bringing energy ashore and thus in nearshore areas that support a number of different human uses. We show that the maximum combined economic benefit from wave energy and other uses is likely to be realized if wave energy facilities are sited in areas that maximize wave energy NPV and minimize conflict with existing ocean uses. Our tools will help decision-makers explore alternative locations for wave energy facilities by mapping expected wave energy NPV and helping to identify sites that provide maximal returns yet avoid spatial competition with existing ocean uses. PMID:23144824

  5. Trapped waves on the mid-latitude β-plane

    NASA Astrophysics Data System (ADS)

    Paldor, Nathan; Sigalov, Andrey

    2008-08-01

    A new type of approximate solutions of the Linearized Shallow Water Equations (LSWE) on the mid-latitude β-plane, zonally propagating trapped waves with Airy-like latitude-dependent amplitude, is constructed in this work, for sufficiently small radius of deformation. In contrast to harmonic Poincare and Rossby waves, these newly found trapped waves vanish fast in the positive half-axis, and their zonal phase speed is larger than that of the corresponding harmonic waves for sufficiently large meridional domains. Our analysis implies that due to the smaller radius of deformation in the ocean compared with that in the atmosphere, the trapped waves are relevant to observations in the ocean whereas harmonic waves typify atmospheric observations. The increase in the zonal phase speed of trapped Rossby waves compared with that of harmonic ones is consistent with recent observations that showed that Sea Surface Height features propagated westwards faster than the phase speed of harmonic Rossby waves.

  6. Self-Reported Executive Functioning in Everyday Life in Parkinson's Disease after Three Months of Subthalamic Deep Brain Stimulation.

    PubMed

    Pham, Uyen Ha Gia; Andersson, Stein; Toft, Mathias; Pripp, Are Hugo; Konglund, Ane Eidahl; Dietrichs, Espen; Malt, Ulrik Fredrik; Skogseid, Inger Marie; Haraldsen, Ira Ronit Hebolt; Solbakk, Anne-Kristin

    2015-01-01

    Objective. Studies on the effect of subthalamic deep brain stimulation (STN-DBS) on executive functioning in Parkinson's disease (PD) are still controversial. In this study we compared self-reported daily executive functioning in PD patients before and after three months of STN-DBS. We also examined whether executive functioning in everyday life was associated with motor symptoms, apathy, and psychiatric symptoms. Method. 40 PD patients were examined with the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A), the Symptom Checklist 90-Revised (SCL-90-R), and the Apathy Evaluation Scale (AES-S). Results. PD patients reported significant improvement in daily life executive functioning after 3 months of STN-DBS. Anxiety scores significantly declined, while other psychiatric symptoms remained unchanged. The improvement of self-reported executive functioning did not correlate with motor improvement after STN-DBS. Apathy scores remained unchanged after surgery. Only preoperative depressed mood had predictive value to the improvement of executive function and appears to prevent potentially favorable outcomes from STN-DBS on some aspects of executive function. Conclusion. PD patients being screened for STN-DBS surgery should be evaluated with regard to self-reported executive functioning. Depressive symptoms in presurgical PD patients should be treated. Complementary information about daily life executive functioning in PD patients might enhance further treatment planning of STN-DBS.

  7. Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson's Disease Is Not Associated with Increased Body Mass Index

    PubMed Central

    Hacker, Mallory L.; Turchan, Maxim; Molinari, Anna L.; Currie, Amanda D.

    2017-01-01

    Previous studies suggest that deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease (PD) leads to weight gain. This study analyzes changes in body mass index (BMI) in 29 subjects from a prospective, single-blind trial of DBS in early stage PD (age 50–75, Hoehn & Yahr stage II off medication, treated with antiparkinsonian medications for ≥6 months but <4 years, and without a history of motor fluctuations, dyskinesias, or dementia). Subjects were randomized to DBS plus optimal drug therapy (DBS+ODT; n = 15) or ODT (n = 14) and followed for 24 months. Weight and height were recorded at baseline and each follow-up visit and used to calculate BMI. BMIs were compared within and between groups using nonparametric t-tests. Mean BMI at baseline was 29.7 in the ODT group and 32.3 in the DBS+ODT group (p > 0.05). BMI change over two years was not different between the groups (p = 0.62, ODT = −0.89; DBS+ODT = −0.17). This study suggests that STN-DBS is not associated with weight gain in subjects with early stage PD. This finding will be tested in an upcoming FDA-approved phase III multicenter, randomized, double-blind, placebo-controlled, pivotal clinical trial evaluating DBS in early stage PD (ClinicalTrials.gov identifier NCT00282152). PMID:28676842

  8. Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson's Disease Is Not Associated with Increased Body Mass Index.

    PubMed

    Millan, Sarah H; Hacker, Mallory L; Turchan, Maxim; Molinari, Anna L; Currie, Amanda D; Charles, David

    2017-01-01

    Previous studies suggest that deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease (PD) leads to weight gain. This study analyzes changes in body mass index (BMI) in 29 subjects from a prospective, single-blind trial of DBS in early stage PD (age 50-75, Hoehn & Yahr stage II off medication, treated with antiparkinsonian medications for ≥6 months but <4 years, and without a history of motor fluctuations, dyskinesias, or dementia). Subjects were randomized to DBS plus optimal drug therapy (DBS+ODT; n = 15) or ODT ( n = 14) and followed for 24 months. Weight and height were recorded at baseline and each follow-up visit and used to calculate BMI. BMIs were compared within and between groups using nonparametric t -tests. Mean BMI at baseline was 29.7 in the ODT group and 32.3 in the DBS+ODT group ( p > 0.05). BMI change over two years was not different between the groups ( p = 0.62, ODT = -0.89; DBS+ODT = -0.17). This study suggests that STN-DBS is not associated with weight gain in subjects with early stage PD. This finding will be tested in an upcoming FDA-approved phase III multicenter, randomized, double-blind, placebo-controlled, pivotal clinical trial evaluating DBS in early stage PD (ClinicalTrials.gov identifier NCT00282152).

  9. Dry and wet granular shock waves.

    PubMed

    Zaburdaev, V Yu; Herminghaus, S

    2007-03-01

    The formation of a shock wave in one-dimensional granular gases is considered, for both the dry and the wet cases, and the results are compared with the analytical shock wave solution in a sticky gas. Numerical simulations show that the behavior of the shock wave in both cases tends asymptotically to the sticky limit. In the inelastic gas (dry case) there is a very close correspondence to the sticky gas, with one big cluster growing in the center of the shock wave, and a step-like stationary velocity profile. In the wet case, the shock wave has a nonzero width which is marked by two symmetric heavy clusters performing breathing oscillations with slowly increasing amplitude. All three models have the same asymptotic energy dissipation law, which is important in the context of the free cooling scenario. For the early stage of the shock formation and asymptotic oscillations we provide analytical results as well.

  10. A switchable spin-wave signal splitter for magnonic networks

    NASA Astrophysics Data System (ADS)

    Heussner, F.; Serga, A. A.; Brächer, T.; Hillebrands, B.; Pirro, P.

    2017-09-01

    The influence of an inhomogeneous magnetization distribution on the propagation of caustic-like spin-wave beams in unpatterned magnetic films has been investigated by utilizing micromagnetic simulations. Our study reveals a locally controllable and reconfigurable tractability of the beam directions. This feature is used to design a device combining split and switch functionalities for spin-wave signals on the micrometer scale. A coherent transmission of spin-wave signals through the device is verified. This attests the applicability in magnonic networks where the information is encoded in the phase of the spin waves.

  11. Wave motion on the surface of the human tympanic membrane: Holographic measurement and modeling analysis

    PubMed Central

    Cheng, Jeffrey Tao; Hamade, Mohamad; Merchant, Saumil N.; Rosowski, John J.; Harrington, Ellery; Furlong, Cosme

    2013-01-01

    Sound-induced motions of the surface of the tympanic membrane (TM) were measured using stroboscopic holography in cadaveric human temporal bones at frequencies between 0.2 and 18 kHz. The results are consistent with the combination of standing-wave-like modal motions and traveling-wave-like motions on the TM surface. The holographic techniques also quantified sound-induced displacements of the umbo of the malleus, as well as volume velocity of the TM. These measurements were combined with sound-pressure measurements near the TM to compute middle-ear input impedance and power reflectance at the TM. The results are generally consistent with other published data. A phenomenological model that behaved qualitatively like the data was used to quantify the relative magnitude and spatial frequencies of the modal and traveling-wave-like displacement components on the TM surface. This model suggests the modal magnitudes are generally larger than those of the putative traveling waves, and the computed wave speeds are much slower than wave speeds predicted by estimates of middle-ear delay. While the data are inconsistent with simple modal displacements of the TM, an alternate model based on the combination of modal motions in a lossy membrane can also explain these measurements without invoking traveling waves. PMID:23363110

  12. All-optical observation and reconstruction of spin wave dispersion

    PubMed Central

    Hashimoto, Yusuke; Daimon, Shunsuke; Iguchi, Ryo; Oikawa, Yasuyuki; Shen, Ka; Sato, Koji; Bossini, Davide; Tabuchi, Yutaka; Satoh, Takuya; Hillebrands, Burkard; Bauer, Gerrit E. W.; Johansen, Tom H.; Kirilyuk, Andrei; Rasing, Theo; Saitoh, Eiji

    2017-01-01

    To know the properties of a particle or a wave, one should measure how its energy changes with its momentum. The relation between them is called the dispersion relation, which encodes essential information of the kinetics. In a magnet, the wave motion of atomic spins serves as an elementary excitation, called a spin wave, and behaves like a fictitious particle. Although the dispersion relation of spin waves governs many of the magnetic properties, observation of their entire dispersion is one of the challenges today. Spin waves whose dispersion is dominated by magnetostatic interaction are called pure-magnetostatic waves, which are still missing despite of their practical importance. Here, we report observation of the band dispersion relation of pure-magnetostatic waves by developing a table-top all-optical spectroscopy named spin-wave tomography. The result unmasks characteristics of pure-magnetostatic waves. We also demonstrate time-resolved measurements, which reveal coherent energy transfer between spin waves and lattice vibrations. PMID:28604690

  13. Deep brain stimulation of the subthalamic nucleus improves temperature sensation in patients with Parkinson's disease.

    PubMed

    Maruo, Tomoyuki; Saitoh, Youichi; Hosomi, Koichi; Kishima, Haruhiko; Shimokawa, Toshio; Hirata, Masayuki; Goto, Tetsu; Morris, Shayne; Harada, Yu; Yanagisawa, Takufumi; Aly, Mohamed M; Yoshimine, Toshiki

    2011-04-01

    Patients with Parkinson's disease (PD) reportedly show deficits in sensory processing in addition to motor symptoms. However, little is known about the effects of bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) on temperature sensation as measured by quantitative sensory testing (QST). This study was designed to quantitatively evaluate the effects of STN-DBS on temperature sensation and pain in PD patients. We conducted a QST study comparing the effects of STN-DBS on cold sense thresholds (CSTs) and warm sense thresholds (WSTs) as well as on cold-induced and heat-induced pain thresholds (CPT and HPT) in 17 PD patients and 14 healthy control subjects. The CSTs and WSTs of patients were significantly smaller during the DBS-on mode when compared with the DBS-off mode (P<.001), whereas the CSTs and WSTs of patients in the DBS-off mode were significantly greater than those of healthy control subjects (P<.02). The CPTs and HPTs in PD patients were significantly larger on the more affected side than on the less affected side (P<.02). Because elevations in thermal sense and pain thresholds of QST are reportedly almost compatible with decreases in sensation, our findings confirm that temperature sensations may be disturbed in PD patients when compared with healthy persons and that STN-DBS can be used to improve temperature sensation in these patients. The mechanisms underlying our findings are not well understood, but improvement in temperature sensation appears to be a sign of modulation of disease-related brain network abnormalities. Copyright © 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  14. Subthalamic and Cortical Local Field Potentials Associated with Pilocarpine-Induced Oral Tremor in the Rat

    PubMed Central

    Long, Lauren L.; Podurgiel, Samantha J.; Haque, Aileen F.; Errante, Emily L.; Chrobak, James J.; Salamone, John D.

    2016-01-01

    Tremulous jaw movements (TJMs) are rapid vertical deflections of the lower jaw that resemble chewing but are not directed at any particular stimulus. In rodents, TJMs are induced by neurochemical conditions that parallel those seen in human Parkinsonism, including neurotoxic or pharmacological depletion of striatal dopamine (DA), DA antagonism, and cholinomimetic administration. Moreover, TJMs in rodents can be attenuated by antiparkinsonian agents, including levodopa (L-DOPA), DA agonists, muscarinic antagonists, and adenosine A2A antagonists. In human Parkinsonian patients, exaggerated physiological synchrony is seen in the beta frequency band in various parts of the cortical/basal ganglia/thalamic circuitry, and activity in the tremor frequency range (3–7 Hz) also has been recorded. The present studies were undertaken to determine if tremor-related local field potential (LFP) activity could be recorded from motor cortex (M1) or subthalamic nucleus (STN) during the TJMs induced by the muscarinic agonist pilocarpine, which is a well-known tremorogenic agent. Pilocarpine induced a robust TJM response that was marked by rhythmic electromyographic (EMG) activity in the temporalis muscle. Compared to periods with no tremor activity, TJM epochs were characterized by increased LFP activity in the tremor frequency range in both neocortex and STN. Tremor activity was not associated with increased synchrony in the beta frequency band. These studies identified tremor-related LFP activity in parts of the cortical/basal ganglia circuitry that are involved in the pathophysiology of Parkinsonism. This research may ultimately lead to identification of the oscillatory neural mechanisms involved in the generation of tremulous activity, and promote development of novel treatments for tremor disorders. PMID:27378874

  15. Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease

    PubMed Central

    Kurcova, Sandra; Bardon, Jan; Vastik, Miroslav; Vecerkova, Marketa; Frolova, Monika; Hvizdosova, Lenka; Nevrly, Martin; Mensikova, Katerina; Otruba, Pavel; Krahulik, David; Kurca, Egon; Sivak, Stefan; Zapletalova, Jana; Kanovsky, Petr

    2018-01-01

    Abstract Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains. Our objective was to elucidate the initial effects of STN-DBS on non-motor and motor symptoms in PD patients in a 4-month follow-up. This open prospective study followed 24 patients with PD who underwent STN-DBS. The patients were examined using dedicated rating scales preoperatively and at 1 and 4 months following STN-DBS to determine initial changes in motor and nonmotor symptoms. Patients at month 1 after STN-DBS had significantly reduced the Parkinson's disease Questionnaire scores (P = .018) and Scales for Outcomes in Parkinson's disease – Autonomic scores (P = .002); these scores had increased at Month 4 after DBS-STN. Nonmotor Symptoms Scale for Parkinson's Disease had improved significantly at Month 1 (P < .001); at Month 4, it remained significantly lower than before stimulation (P = .036). There was no significant difference in The Parkinson's Disease Sleep Scaleat Month 1 and significant improvement at Month 4 (P = .026). There were no significant changes in The Female Sexual Function Index or International Index of Erectile Function. Movement Disorder Society Unified Parkinson's Disease Rating Scale, Part III scores show significant improvements at Month 1 (P < .001) and at Month 4 (P < .001). STN-DBS in patients with advanced PD clearly improves not only motor symptoms, but also several domains of nonmotor functions, namely sleep, autonomic functions and quality of life quickly following the start of stimulation. PMID:29384860

  16. Wave Clouds over Ireland

    NASA Image and Video Library

    2017-12-08

    Visualization Date 2003-12-18 Clouds ripple over Ireland and Scotland in a wave pattern, similar to the pattern of waves along a seashore. The similarity is not coincidental — the atmosphere behaves like a fluid, so when it encounters an obstacle, it must move around it. This movement forms a wave, and the wave movement can continue for long distances. In this case, the waves were caused by the air moving over and around the mountains of Scotland and Ireland. As the air crested a wave, it cooled, and clouds formed. Then, as the air sank into the trough, the air warmed, and clouds did not form. This pattern repeated itself, with clouds appearing at the peak of every wave. Other types of clouds are also visible in the scene. Along the northwestern and southwestern edges of this true-color image from December 17, 2003, are normal mid-altitude clouds with fairly uniform appearances. High altitude cirrus-clouds float over these, casting their shadows on the lower clouds. Open- and closed-cell clouds formed off the coast of northwestern France, and thin contrail clouds are visible just east of these. Contrail clouds form around the particles carried in airplane exhaust. Fog is also visible in the valleys east of the Cambrian Mountains, along the border between northern/central Wales and England. This is an Aqua MODIS image. Sensor Aqua/MODIS Credit Jacques Descloitres, MODIS Rapid Response Team, NASA/GSFC For more information go to: visibleearth.nasa.gov/view_rec.php?id=6146

  17. Evidence from a rare case study for Hebbian-like changes in structural connectivity induced by long-term deep brain stimulation.

    PubMed

    van Hartevelt, Tim J; Cabral, Joana; Møller, Arne; FitzGerald, James J; Green, Alexander L; Aziz, Tipu Z; Deco, Gustavo; Kringelbach, Morten L

    2015-01-01

    It is unclear whether Hebbian-like learning occurs at the level of long-range white matter connections in humans, i.e., where measurable changes in structural connectivity (SC) are correlated with changes in functional connectivity. However, the behavioral changes observed after deep brain stimulation (DBS) suggest the existence of such Hebbian-like mechanisms occurring at the structural level with functional consequences. In this rare case study, we obtained the full network of white matter connections of one patient with Parkinson's disease (PD) before and after long-term DBS and combined it with a computational model of ongoing activity to investigate the effects of DBS-induced long-term structural changes. The results show that the long-term effects of DBS on resting-state functional connectivity is best obtained in the computational model by changing the structural weights from the subthalamic nucleus (STN) to the putamen and the thalamus in a Hebbian-like manner. Moreover, long-term DBS also significantly changed the SC towards normality in terms of model-based measures of segregation and integration of information processing, two key concepts of brain organization. This novel approach using computational models to model the effects of Hebbian-like changes in SC allowed us to causally identify the possible underlying neural mechanisms of long-term DBS using rare case study data. In time, this could help predict the efficacy of individual DBS targeting and identify novel DBS targets.

  18. Omnidirectional spin-wave nanograting coupler

    PubMed Central

    Yu, Haiming; Duerr, G.; Huber, R.; Bahr, M.; Schwarze, T.; Brandl, F.; Grundler, D.

    2013-01-01

    Magnonics as an emerging nanotechnology offers functionalities beyond current semiconductor technology. Spin waves used in cellular nonlinear networks are expected to speed up technologically, demanding tasks such as image processing and speech recognition at low power consumption. However, efficient coupling to microelectronics poses a vital challenge. Previously developed techniques for spin-wave excitation (for example, by using parametric pumping in a cavity) may not allow for the relevant downscaling or provide only individual point-like sources. Here we demonstrate that a grating coupler of periodically nanostructured magnets provokes multidirectional emission of short-wavelength spin waves with giantly enhanced amplitude compared with a bare microwave antenna. Exploring the dependence on ferromagnetic materials, lattice constants and the applied magnetic field, we find the magnonic grating coupler to be more versatile compared with gratings in photonics and plasmonics. Our results allow one to convert, in particular, straight microwave antennas into omnidirectional emitters for short-wavelength spin waves, which are key to cellular nonlinear networks and integrated magnonics. PMID:24189978

  19. Network effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output.

    PubMed

    Humphries, Mark D; Gurney, Kevin

    2012-07-01

    Deep brain stimulation (DBS) is a remarkably successful treatment for the motor symptoms of Parkinson's disease. High-frequency stimulation of the subthalamic nucleus (STN) within the basal ganglia is a main clinical target, but the physiological mechanisms of therapeutic STN DBS at the cellular and network level are unclear. We set out to begin to address the hypothesis that a mixture of responses in the basal ganglia output nuclei, combining regularized firing and inhibition, is a key contributor to the effectiveness of STN DBS. We used our computational model of the complete basal ganglia circuit to show how such a mixture of responses in basal ganglia output naturally arises from the network effects of STN DBS. We replicated the diversification of responses recorded in a primate STN DBS study to show that the model's predicted mixture of responses is consistent with therapeutic STN DBS. We then showed how this 'mixture of response' perspective suggests new ideas for DBS mechanisms: first, that the therapeutic frequency of STN DBS is above 100 Hz because the diversification of responses exhibits a step change above this frequency; and second, that optogenetic models of direct STN stimulation during DBS have proven therapeutically ineffective because they do not replicate the mixture of basal ganglia output responses evoked by electrical DBS. © 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

  20. Relativistic distorted-wave collision strengths for the 49 Δn=0 optically allowed transitions with n=2 in the 67 N-like ions with 26≤Z≤92

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fontes, Christopher J., E-mail: cjf@lanl.gov; Zhang, Hong Lin

    2014-09-15

    Relativistic distorted-wave collision strengths have been calculated for the 49 Δn=0 optically allowed transitions with n=2 in the 67 N-like ions with nuclear charge number Z in the range 26≤Z≤92. The calculations were made for the four final, or scattered, electron energies E{sup ′}=0.20, 0.42, 0.80, and 1.40, where E{sup ′} is in units of Z{sub eff}{sup 2} Ry with Z{sub eff}=Z−5. In the present calculations, an improved “top-up” method, which employs relativistic plane waves, was used to obtain the high partial-wave contribution for each transition, in contrast to the partial-relativistic Coulomb–Bethe approximation used in the previous work by Zhangmore » and Sampson [H.L. Zhang and D.H. Sampson, At. Data Nucl. Data Tables 72 (1999) 153]. In that earlier work, collision strengths were also provided for N-like ions, but for a more comprehensive data set consisting of all possible 105 Δn=0 transitions, six scattered energies and the 81 ions with Z in the range 12≤Z≤92. The collision strengths covered in the present work should be more accurate than the corresponding data given by Zhang and Sampson [H.L. Zhang and D.H. Sampson, At. Data Nucl. Data Tables 72 (1999) 153] and are presented here to replace those earlier results.« less

  1. Relativistic distorted-wave collision strengths for the 16 Δn=0 optically allowed transitions with n=2 in the 67 O-like ions with 26≤Z≤92

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fontes, Christopher J., E-mail: cjf@lanl.gov; Zhang, Hong Lin

    2015-01-15

    Relativistic distorted-wave collision strengths have been calculated for the 16 Δn=0 optically allowed transitions with n=2 in the 67 O-like ions with nuclear charge number Z in the range 26≤Z≤92. The calculations were made for the four final, or scattered, electron energies E{sup ′}=0.20,0.42,0.80, and 1.40, where E{sup ′} is in units of Z{sub eff}{sup 2} Ry with Z{sub eff}=Z−5.83. In the present calculations, an improved “top-up” method, which employs relativistic plane waves, was used to obtain the high partial-wave contribution for each transition, in contrast to the partial-relativistic Coulomb–Bethe approximation used in previous work by Zhang and Sampson [H.L.more » Zhang, D.H. Sampson, At. Data Nucl. Data Tables 82 (2002) 357]. In that earlier work, collision strengths were also provided for O-like ions, but for a more comprehensive data set consisting of all possible 45 Δn=0 transitions, six scattered energies, and the 79 ions with Z in the range 14≤Z≤92. The collision strengths covered in the present work should be more accurate than the corresponding data given by Zhang and Sampson [H.L. Zhang, D.H. Sampson, At. Data Nucl. Data Tables 82 (2002) 357] and are presented here to replace those earlier results.« less

  2. Relativistic distorted-wave collision strengths for the 49 Δn=0 optically allowed transitions with n=2 in the 67 B-like ions with 26≤Z≤92

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fontes, Christopher J., E-mail: cjf@lanl.gov; Zhang, Hong Lin

    2014-05-15

    Relativistic distorted-wave collision strengths have been calculated for the 49 Δn=0 optically allowed transitions with n=2 in the 67 B-like ions with nuclear charge number Z in the range 26≤Z≤92. The calculations were made for the four final, or scattered, electron energies E{sup ′}=0.20, 0.42, 0.80, and 1.40, where E{sup ′} is in units of Z{sub eff}{sup 2} Ry with Z{sub eff}=Z−3.33. In the present calculations, an improved “top-up” method, which employs relativistic plane waves, was used to obtain the high partial-wave contribution for each transition, in contrast to the partial-relativistic Coulomb–Bethe approximation used in previous work by Zhang andmore » Sampson [H.L. Zhang and D.H. Sampson, At. Data Nucl. Data Tables 56 (1994) 41]. In that earlier work, collision strengths were also provided for B-like ions, but for a more comprehensive data set consisting of all 105 Δn=0 transitions, six scattered energies and the 85 ions with Z in the range 8≤Z≤92. The collision strengths covered in the present work should be more accurate than the corresponding data given by Zhang and Sampson [H.L. Zhang and D.H. Sampson, At. Data Nucl. Data Tables 56 (1994) 41] and are presented here to replace those earlier results.« less

  3. Instability of a Planar Expansion Wave

    DTIC Science & Technology

    2005-10-11

    Israel 3E. T. S. I. Industriales , Universidad de Castilla-La Mancha, 13071 Cuidad Real, Spain Received 18 March 2005; published 11 October 2005 An...modulation amplitude m=dx. As first shown in 3, for ideal gases with moderate values of , like 5 3 or 7 5 , m in a rippled rarefaction wave exhibits...radiating gases . The accuracy of such approximation is beyond the scope of the present paper see 17 and refer- ences therein. A blast wave

  4. The impact of pallidal and subthalamic deep brain stimulation on urologic function in Parkinson’s disease

    PubMed Central

    Mock, Stephen; Osborn, David J.; Brown, Elizabeth T.; Reynolds, W. Stuart; Turchan, Maxim; Pallavaram, Srivatsan; Rodriguez, William; Dmochowski, Roger; Tolleson, Christopher M.

    2016-01-01

    Objective Deep Brain Stimulation (DBS) is an established adjunctive surgical intervention for treating Parkinson’s disease (PD) motor symptoms. Both surgical targets, the globus pallidus interna (GPi) and subthalamic nucleus (STN), appear equally beneficial when treating motor symptoms but effects on nonmotor symptoms are not clear. Lower urinary tract symptoms (LUTS) are a common PD complaint. Given prior data in STN-DBS, we aimed to further explore potential benefits in LUTS in both targets. Methods We performed a prospective, non-blinded clinical trial evaluating LUTS in PD patients in both targets pre and post DBS using validated urologic surveys. Participants were already slated for DBS and target selection predetermined before study entry. LUTS was evaluated using: the American Urological Association (AUA-SI), Quality of Life score (QOL), Overactive bladder 8 questionnaire (OAB-q), and sexual health inventory for men (SHIM). Results Of 33 participants, 20 underwent STN DBS and 13 had GPi DBS. Patients demonstrated moderate baseline LUTS. The urologic QOL score significantly improved post DBS (3.24±1.77vs 2.52±1.30; p=0.03). Analyzed by target, only the STN showed significant change in QOL (vs. 2.25±1.33; p=0.04). There were no other significant differences in urologic scores post DBS noted in either target. Conclusion In PD patients with moderate LUTS, there were notable improvements in QOL for LUTS post DBS in the total sample and STN target. There may be differences in DBS effects on LUTS between targets but this will require further larger, blinded studies. PMID:27172446

  5. Deep Brain Stimulation for Essential Tremor: Aligning Thalamic and Posterior Subthalamic Targets in 1 Surgical Trajectory.

    PubMed

    Bot, Maarten; van Rootselaar, Fleur; Contarino, Maria Fiorella; Odekerken, Vincent; Dijk, Joke; de Bie, Rob; Schuurman, Richard; van den Munckhof, Pepijn

    2017-12-21

    Ventral intermediate nucleus (VIM) deep brain stimulation (DBS) and posterior subthalamic area (PSA) DBS suppress tremor in essential tremor (ET) patients, but it is not clear which target is optimal. Aligning both targets in 1 surgical trajectory would facilitate exploring stimulation of either target in a single patient. To evaluate aligning VIM and PSA in 1 surgical trajectory for DBS in ET. Technical aspects of trajectories, intraoperative stimulation findings, final electrode placement, target used for chronic stimulation, and adverse and beneficial effects were evaluated. In 17 patients representing 33 trajectories, we successfully aligned VIM and PSA targets in 26 trajectories. Trajectory distance between targets averaged 7.2 (range 6-10) mm. In all but 4 aligned trajectories, optimal intraoperative tremor suppression was obtained in the PSA. During follow-up, active electrode contacts were located in PSA in the majority of cases. Overall, successful tremor control was achieved in 69% of patients. Stimulation-induced dysarthria or gait ataxia occurred in, respectively, 56% and 44% of patients. Neither difference in tremor suppression or side effects was noted between aligned and nonaligned leads nor between the different locations of chronic stimulation. Alignment of VIM and PSA for DBS in ET is feasible and enables intraoperative exploration of both targets in 1 trajectory. This facilitates positioning of electrode contacts in both areas, where multiple effective points of stimulation can be found. In the majority of aligned leads, optimal intraoperative and chronic stimulation were located in the PSA. Copyright © 2017 by the Congress of Neurological Surgeons

  6. Electrode Position and Current Amplitude Modulate Impulsivity after Subthalamic Stimulation in Parkinsons Disease—A Computational Study

    PubMed Central

    Mandali, Alekhya; Chakravarthy, V. Srinivasa; Rajan, Roopa; Sarma, Sankara; Kishore, Asha

    2016-01-01

    Background: Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) is highly effective in alleviating motor symptoms of Parkinson's disease (PD) which are not optimally controlled by dopamine replacement therapy. Clinical studies and reports suggest that STN-DBS may result in increased impulsivity and de novo impulse control disorders (ICD). Objective/Hypothesis: We aimed to compare performance on a decision making task, the Iowa Gambling Task (IGT), in healthy conditions (HC), untreated and medically-treated PD conditions with and without STN stimulation. We hypothesized that the position of electrode and stimulation current modulate impulsivity after STN-DBS. Methods: We built a computational spiking network model of basal ganglia (BG) and compared the model's STN output with STN activity in PD. Reinforcement learning methodology was applied to simulate IGT performance under various conditions of dopaminergic and STN stimulation where IGT total and bin scores were compared among various conditions. Results: The computational model reproduced neural activity observed in normal and PD conditions. Untreated and medically-treated PD conditions had lower total IGT scores (higher impulsivity) compared to HC (P < 0.0001). The electrode position that happens to selectively stimulate the part of the STN corresponding to an advantageous panel on IGT resulted in de-selection of that panel and worsening of performance (P < 0.0001). Supratherapeutic stimulation amplitudes also worsened IGT performance (P < 0.001). Conclusion(s): In our computational model, STN stimulation led to impulsive decision making in IGT in PD condition. Electrode position and stimulation current influenced impulsivity which may explain the variable effects of STN-DBS reported in patients. PMID:27965590

  7. Posterolateral Trajectories Favor a Longer Motor Domain in Subthalamic Nucleus Deep Brain Stimulation for Parkinson Disease.

    PubMed

    Tamir, Idit; Marmor-Levin, Odeya; Eitan, Renana; Bergman, Hagai; Israel, Zvi

    2017-10-01

    The clinical outcome of patients with Parkinson disease (PD) who undergo subthalamic nucleus (STN) deep brain stimulation (DBS) is, in part, determined by the length of the electrode trajectory through the motor STN domain, the dorsolateral oscillatory region (DLOR). Trajectory length has been found to correlate with the stimulation-related improvement in patients' motor function (estimated by part III of the United Parkinson's Disease Rating Scale [UPDRS]). Therefore, it seems that ideally trajectories should have maximal DLOR length. We retrospectively studied the influence of various anatomic aspects of the brains of patients with PD and the geometry of trajectories planned on the length of the DLOR and STN recorded during DBS surgery. We examined 212 trajectories and 424 microelectrode recording tracks in 115 patients operated on in our center between 2010 and 2015. We found a strong correlation between the length of the recorded DLOR and STN. Trajectories that were more lateral and/or posterior in orientation had a longer STN and DLOR pass, although the DLOR/STN fraction length remained constant. The STN target was more lateral when the third ventricle was wider, and the latter correlated with older age and male gender. Trajectory angles correlate with the recorded STN and DLOR lengths, and should be altered toward a more posterolateral angle in older patients and atrophied brains to compensate for the changes in STN location and geometry. These fine adjustments should yield a longer motor domain pass, thereby improving the patient's predicted outcome. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Deformation and deceleration of coronal wave

    NASA Astrophysics Data System (ADS)

    Xue, Z. K.; Qu, Z. Q.; Yan, X. L.; Zhao, L.; Ma, L.

    2013-08-01

    Aims: We studied the kinematics and morphology of two coronal waves to better understand the nature and origin of coronal waves. Methods: Using multi-wavelength observations of the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO) and the Extreme Ultraviolet Imager (EUVI) on board the twin spacecraft Solar-TErrestrial RElations Observatory (STEREO), we present morphological and dynamic characteristics of consecutive coronal waves on 2011 March 24. We also show the coronal magnetic field based on the potential field source surface model. Results: This event contains several interesting aspects. The first coronal wave initially appeared after a surge-like eruption. Its front was changed and deformed significantly from a convex shape to a line-shaped appearance, and then to a concave configuration during its propagation to the northwest. The initial speeds ranged from 947 km s-1 to 560 km s-1. The first wave decelerated significantly after it passed through a filament channel. After the deceleration, the final propagation speeds of the wave were from 430 km s-1 to 312 km s-1. The second wave was found to appear after the first wave in the northwest side of the filament channel. Its wave front was more diffused and the speed was around 250 km s-1, much slower than that of the first wave. Conclusions: The deformation of the first coronal wave was caused by the different speeds along different paths. The sudden deceleration implies that the refraction of the first wave took place at the boundary of the filament channel. The event provides evidence that the first coronal wave may be a coronal MHD shock wave, and the second wave may be the apparent propagation of the brightenings caused by successive stretching of the magnetic field lines.

  9. Steering attosecond electron wave packets with light.

    PubMed

    Kienberger, R; Hentschel, M; Uiberacker, M; Spielmann, Ch; Kitzler, M; Scrinzi, A; Wieland, M; Westerwalbesloh, Th; Kleineberg, U; Heinzmann, U; Drescher, M; Krausz, F

    2002-08-16

    Photoelectrons excited by extreme ultraviolet or x-ray photons in the presence of a strong laser field generally suffer a spread of their energies due to the absorption and emission of laser photons. We demonstrate that if the emitted electron wave packet is temporally confined to a small fraction of the oscillation period of the interacting light wave, its energy spectrum can be up- or downshifted by many times the laser photon energy without substantial broadening. The light wave can accelerate or decelerate the electron's drift velocity, i.e., steer the electron wave packet like a classical particle. This capability strictly relies on a sub-femtosecond duration of the ionizing x-ray pulse and on its timing to the phase of the light wave with a similar accuracy, offering a simple and potentially single-shot diagnostic tool for attosecond pump-probe spectroscopy.

  10. 1918 pandemic morbidity: The first wave hits the poor, the second wave hits the rich.

    PubMed

    Mamelund, Svenn-Erik

    2018-05-01

    Whether morbidity from the 1918-19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue, the recent literature has hypothesized that morbidity was "socially neutral." To study the associations between influenza-like illness (ILI) and socioeconomic status (SES), gender, and wave during the 1918-19 influenza pandemic. Availability of incidence data on the 1918-19 pandemic is scarce, in particular for waves other than the "fall wave" October-December 1918. Here, an overlooked survey from Bergen, Norway (n = 10 633), is used to study differences in probabilities of ILI and ILI probability ratios by apartment size as a measure of SES and gender for 3 waves including the waves prior to and after the "fall wave." Socioeconomic status was negatively associated with ILI in the first wave, but positively associated in the second wave. At all SES levels, men had the highest ILI in the summer, while women had the highest ILI in the fall. There were no SES or gender differences in ILI in the winter of 1919. For the first time, it is documented a crossover in the role of socioeconomic status in 1918 pandemic morbidity. The poor came down with influenza first, while the rich with less exposure in the first wave had the highest morbidity in the second wave. The study suggests that the socioeconomically disadvantaged should be prioritized if vaccines are of limited availability in a future pandemic. © 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

  11. Bilateral high-frequency stimulation of the subthalamic nucleus on attentional performance: transient deleterious effects and enhanced motivation in both intact and parkinsonian rats

    PubMed Central

    Baunez, Christelle; Christakou, Anastasia; Chudasama, Yogita; Forni, Claude; Robbins, Trevor W.

    2007-01-01

    It is now well established that subthalamic nucleus high-frequency stimulation (STN HFS) alleviates motor problems in Parkinson's disease. However, its efficacy for cognitive function remains a matter of debate. The aim of this study was to assess the effects of STN HFS in rats performing a visual attentional task. Bilateral STN HFS was applied in intact and in bilaterally dopamine (DA)-depleted rats. In all animals, STN HFS had a transient debilitating effect on all the variables measured in the task. In DA-depleted rats, STN HFS did not alleviate the deficits induced by the DA lesion such as omissions and latency to make correct responses, but induced perseverative approaches to the food magazine, an indicator of enhanced motivation. In sham-operated controls, STN HFS significantly reduced accuracy and induced perseverative behaviour, mimicking partially the effects of bilateral STN lesions in the same task. These results are in line with the hypothesis that STN HFS only partially mimics inactivation of STN produced by lesioning and confirm the motivational exacerbation induced by STN inactivation. PMID:17331214

  12. Gravitational-wave astronomy: delivering on the promises.

    PubMed

    Schutz, B F

    2018-05-28

    Now that LIGO and Virgo have begun to detect gravitational-wave events with regularity, the field of gravitational-wave astronomy is beginning to realize its promise. Binary black holes and, very recently, binary neutron stars have been observed, and we are already learning much from them. The future, with improved sensitivity, more detectors and detectors like LISA in different frequency bands, has even more promise to open a completely hidden side of the Universe to our exploration.This article is part of a discussion meeting issue 'The promises of gravitational-wave astronomy'. © 2018 The Author(s).

  13. Nonlinear physics of electrical wave propagation in the heart: a review

    NASA Astrophysics Data System (ADS)

    Alonso, Sergio; Bär, Markus; Echebarria, Blas

    2016-09-01

    The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is triggered by a periodic sequence of electrical waves (action potentials) originating in the sino-atrial node and propagating over the atria and the ventricles. Cardiac arrhythmias like atrial and ventricular fibrillation (AF,VF) or ventricular tachycardia (VT) are caused by disruptions and instabilities of these electrical excitations, that lead to the emergence of rotating waves (VT) and turbulent wave patterns (AF,VF). Numerous simulation and experimental studies during the last 20 years have addressed these topics. In this review we focus on the nonlinear dynamics of wave propagation in the heart with an emphasis on the theory of pulses, spirals and scroll waves and their instabilities in excitable media with applications to cardiac modeling. After an introduction into electrophysiological models for action potential propagation, the modeling and analysis of spatiotemporal alternans, spiral and scroll meandering, spiral breakup and scroll wave instabilities like negative line tension and sproing are reviewed in depth and discussed with emphasis on their impact for cardiac arrhythmias.

  14. Ship-wave-shaped wave clouds induced by the Crozet Islands, south Indian Ocean

    NASA Image and Video Library

    2017-12-08

    There are special places on Earth that sometimes write their personal signature in the clouds. The Crozet Islands are one such place, thanks to the tall volcanic peaks that grace the islands. When air flows around these tall peaks, it gets pushed around the islands as well as up and over the peak. The net effect of the flowing air flowing around the solid, tall peaks is much like the solid bow of a ship cutting through standing water. In each case v-shaped waves are formed behind the motion. In liquid, this is called a wake; in the atmosphere, when clouds are present or created, they are known as ship-wave-shaped clouds. The Moderate Resolution Imaging Spectroradiometer (MODIS) aboard NASA’s Terra satellite captured this true-color image as it passed over the Crozet Islands on November 26, 2014. Three distinct waves are seen behind the three largest islands. From west to east these are Pig Island, Possession Island and East Island. Credit: NASA/GSFC/Jeff Schmaltz/MODIS Land Rapid Response Team NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  15. Frequency specific activity in subthalamic nucleus correlates with hand bradykinesia in Parkinson's disease.

    PubMed

    Tan, Huiling; Pogosyan, Alek; Anzak, Anam; Foltynie, Thomas; Limousin, Patricia; Zrinzo, Ludvic; Ashkan, Keyoumars; Bogdanovic, Marko; Green, Alexander L; Aziz, Tipu; Brown, Peter

    2013-02-01

    Local field potential recordings made from the basal ganglia of patients undergoing deep brain stimulation have suggested that frequency specific activity is involved in determining the rate of force development and the peak force at the outset of a movement. However, the extent to which the basal ganglia might be involved in motor performance later on in a sustained contraction is less clear. We therefore recorded from the subthalamic nucleus region (STNr) in patients with Parkinson's disease (PD) as they made maximal voluntary grips. Relative to age-matched controls they had more rapid force decrement when contraction was meant to be sustained and prolonged release reaction time and slower rate of force offset when they were supposed to release the grip. These impairments were independent from medication status. Increased STNr power over 5-12 Hz (in the theta/alpha band) independently predicted better performance-reduced force decrement, shortened release reaction time and faster rate of force offset. In contrast, lower mean levels and progressive reduction of STNr power over 55-375 Hz (high gamma/high frequency) over the period when contraction was meant to be sustained were both strongly associated with greater force decrement over time. Higher power over 13-23 Hz (low beta) was associated with more rapid force decrement during the period when grip should have been sustained, and with a paradoxical shortening of the release reaction time. These observations suggest that STNr activities at 5-12 Hz and 55-375 Hz are necessary for optimal grip performance and that deficiencies of such activities lead to motor impairments. In contrast, increased levels of 13-25 Hz activity both promote force decrement and shorten the release reaction time, consistent with a role in antagonising (and terminating) voluntary movement. Frequency specific oscillatory activities in the STNr impact on motor performance from the beginning to the end of a voluntary grip. Copyright © 2012

  16. Frequency specific activity in subthalamic nucleus correlates with hand bradykinesia in Parkinson's disease

    PubMed Central

    Tan, Huiling; Pogosyan, Alek; Anzak, Anam; Foltynie, Thomas; Limousin, Patricia; Zrinzo, Ludvic; Ashkan, Keyoumars; Bogdanovic, Marko; Green, Alexander L.; Aziz, Tipu; Brown, Peter

    2013-01-01

    Local field potential recordings made from the basal ganglia of patients undergoing deep brain stimulation have suggested that frequency specific activity is involved in determining the rate of force development and the peak force at the outset of a movement. However, the extent to which the basal ganglia might be involved in motor performance later on in a sustained contraction is less clear. We therefore recorded from the subthalamic nucleus region (STNr) in patients with Parkinson's disease (PD) as they made maximal voluntary grips. Relative to age-matched controls they had more rapid force decrement when contraction was meant to be sustained and prolonged release reaction time and slower rate of force offset when they were supposed to release the grip. These impairments were independent from medication status. Increased STNr power over 5–12 Hz (in the theta/alpha band) independently predicted better performance—reduced force decrement, shortened release reaction time and faster rate of force offset. In contrast, lower mean levels and progressive reduction of STNr power over 55–375 Hz (high gamma/high frequency) over the period when contraction was meant to be sustained were both strongly associated with greater force decrement over time. Higher power over 13–23 Hz (low beta) was associated with more rapid force decrement during the period when grip should have been sustained, and with a paradoxical shortening of the release reaction time. These observations suggest that STNr activities at 5–12 Hz and 55–375 Hz are necessary for optimal grip performance and that deficiencies of such activities lead to motor impairments. In contrast, increased levels of 13–25 Hz activity both promote force decrement and shorten the release reaction time, consistent with a role in antagonising (and terminating) voluntary movement. Frequency specific oscillatory activities in the STNr impact on motor performance from the beginning to the end of a voluntary grip

  17. Quality of life outcome after subthalamic stimulation in Parkinson's disease depends on age.

    PubMed

    Dafsari, Haidar S; Reker, Paul; Stalinski, Lisa; Silverdale, Monty; Rizos, Alexandra; Ashkan, Keyoumars; Barbe, Michael T; Fink, Gereon R; Evans, Julian; Steffen, Julia; Samuel, Michael; Dembek, Till A; Visser-Vandewalle, Veerle; Antonini, Angelo; Ray-Chaudhuri, K; Martinez-Martin, Pablo; Timmermann, Lars

    2018-01-01

    The purpose of this study was to investigate how quality of life outcome after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) depends on age. In this prospective, open-label, multicenter study including 120 PD patients undergoing bilateral STN-DBS, we investigated the PDQuestionnaire-8 (PDQ-8), Unified PD Rating Scale-III, Scales for Outcomes in PD-motor examination, complications, activities of daily living, and levodopa equivalent daily dose preoperatively and at 5 months follow-up. Significant changes at follow-up were analyzed with Wilcoxon signed-rank test and Bonferroni correction for multiple comparisons. To explore the influence of age post hoc, the patients were classified into 3 age groups (≤59, 60-69, ≥70 years). Intragroup changes were analyzed with Wilcoxon signed-rank and intergroup differences with Kruskal-Wallis tests. The strength of clinical responses was evaluated using effect size. The PDQuestionnaire-8, Scales for Outcomes in PD-motor complications, activities of daily living, and levodopa equivalent daily dose significantly improved in the overall cohort and all age groups with no significant intergroup differences. However, PDQuestionnaire-8 effect sizes for age groups ≤59, 60 to 69, and ≥70 years, respectively, were strong, moderate, and small. Furthermore, PDQuestionnaire-8 domain analyses revealed that all domains except cognition and emotional well-being significantly improved in patients aged ≤59 years, whereas only communication, activities of daily living, and stigma improved in patients aged 60-69 years, and activities of daily living and stigma in patients aged ≥70 years. Although quality of life, motor complications, and activities of daily living significantly improved in all age groups after bilateral STN-DBS, the beneficial effect on overall quality of life was more pronounced and affected a wider range of quality of life domains in younger patients. © 2017 International

  18. Subthalamic stimulation may inhibit the beneficial effects of levodopa on akinesia and gait.

    PubMed

    Fleury, Vanessa; Pollak, Pierre; Gere, Julien; Tommasi, Giorgio; Romito, Luigi; Combescure, Christophe; Bardinet, Eric; Chabardes, Stephan; Momjian, Shahan; Krainik, Alexandre; Burkhard, Pierre; Yelnik, Jérôme; Krack, Paul

    2016-09-01

    Gait and akinesia deterioration in PD patients during the immediate postoperative period of DBS has been directly related to stimulation in the subthalamic region. The underlying mechanisms remain poorly understood. The aim of the present study was to clinically and anatomically describe this side effect. PD patients presenting with a worsening of gait and/or akinesia following STN-DBS, that was reversible on stimulation arrest were included. The evaluation included (1) a Stand Walk Sit Test during a monopolar survey of each electrode in the on-drug condition; (2) a 5-condition test with the following conditions: off-drug/off-DBS, off-drug/on-best-compromise-DBS, on-drug/off-DBS, on-drug/on-best-compromise-DBS, and on-drug/on-worsening-DBS, which utilized the contact inducing the most prominent gait deterioration. The following scales were performed: UPDRSIII subscores, Stand Walk Sit Test, and dyskinesia and freezing of gait scales. Localization of contacts was performed using a coregistration method. Twelve of 17 patients underwent the complete evaluation. Stimulation of the most proximal contacts significantly slowed down the Stand Walk Sit Test. The on-drug/on-worsening-DBS condition compared with the on-drug/off-DBS condition worsened akinesia (P = 0.02), Stand Walk Sit Test (P = 0.001), freezing of gait (P = 0.02), and improved dyskinesias (P = 0.003). Compared with the off-drug/off-DBS condition, the on-drug/on-worsening-DBS condition improved rigidity (P = 0.007) and tremor (P = 0.007). Worsening contact sites were predominantly dorsal and anterior to the STN in the anterior zona incerta and Forel fields H2. A paradoxical deterioration of gait and akinesia is a rare side effect following STN-DBS. We propose that this may be related to misplaced contacts, and we discuss the pathophysiology and strategies to identify and manage this complication. © 2016 International Parkinson and Movement Disorder Society. © 2016 International

  19. MRI directed bilateral stimulation of the subthalamic nucleus in patients with Parkinson's disease

    PubMed Central

    Patel, N; Plaha, P; O'Sullivan, K; McCarter, R; Heywood, P; Gill, S

    2003-01-01

    Objective: Bilateral chronic high frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as an appropriate therapy for patients with advanced Parkinson's disease refractory to medical therapy. Advances in neuroimaging and neurophysiology have led to the development of varied targeting methods for the delivery of this treatment. Intraoperative neurophysiological and clinical monitoring is regarded by many to be mandatory for accurate STN localisation. We have examined efficacy of bilateral STN stimulation using a predominantly magnetic resonance imaging (MRI)-directed technique. Methods: DBS leads were stereotactically implanted into the STN using an MRI directed method, with intraoperative macrostimulation used purely for adjustment. The effects of DBS were evaluated in 16 patients followed up to 12 months, and compared with baseline assessments. Assessments were performed in both off and on medication states, and were based on the Unified Parkinson's Disease Rating Scale (UPDRS) and timed motor tests. Functional status outcomes were examined using the PDQ-39 quality of life questionnaire. A battery of psychometric tests was used to assess cognition. Results: After 12 months, stimulation in the off medication state resulted in significant improvements in Activities of Daily Living and Motor scores (UPDRS parts II and III) by 62% and 61% respectively. Timed motor tests were significantly improved in the off medication state. Motor scores (UPDRS part III) were significantly improved by 40% in the on medication state. Dyskinesias and off duration were significantly reduced and the mean dose of L-dopa equivalents was reduced by half. Psychometric test scores were mostly unchanged or improved. Adverse events were few. Conclusions: An MRI directed targeting method for implantation of DBS leads into the STN can be used safely and effectively, and results are comparable with studies using intraoperative microelectrode neurophysiological

  20. Mechanics of the acoustic radiation force in tissue-like solids

    NASA Astrophysics Data System (ADS)

    Dontsov, Egor V.

    The acoustic radiation force (ARF) is a phenomenon affiliated with the nonlinear effects of high-intensity wave propagation. It represents the mean momentum transfer from the sound wave to the medium, and allows for an effective computation of the mean motion (e.g. acoustic streaming in fluids) induced by a high-intensity sound wave. Nowadays, the high-intensity focused ultrasound is frequently used in medical diagnosis applications due to its ability to "push" inside the tissue with the radiation body force and facilitate the local quantification of tissue's viscoelastic properties. The main objectives of this study include: i) the theoretical investigation of the ARF in fluids and tissue-like solids generated respectively by the amplitude modulated plane wave and focused ultrasound; ii) computation of the nonlinear acoustic wave propagation when the amplitude of the focused ultrasound field is modulated by a low-frequency signal, and iii) modeling of the ARF-induced motion in tissue-like solids for the purpose of quantifying their nonlinear elasticity via the magnitude of the ARF. Regarding the first part, a comparison with the existing theory of the ARF reveals a number of key features that are brought to light by the new formulation, including the contributions to the ARF of ultrasound modulation and thermal expansion, as well as the precise role of constitutive nonlinearities in generating the sustained body force in tissue-like solids by a focused ultrasound beam. In the second part, the hybrid time-frequency domain algorithm for the numerical analysis of the nonlinear wave equation is proposed. The approach is validated by comparing the results to the finite-difference modeling in time domain. Regarding the third objective, the Fourier transform approach is used to compute the ARF-induced shear wave motion in tissue-mimicking phantoms. A comparison between the experiment (tests performed at the Mayo Clinic) and model permitted the estimation of a particular

  1. Multicomponent long-wave-short-wave resonance interaction system: Bright solitons, energy-sharing collisions, and resonant solitons.

    PubMed

    Sakkaravarthi, K; Kanna, T; Vijayajayanthi, M; Lakshmanan, M

    2014-11-01

    We consider a general multicomponent (2+1)-dimensional long-wave-short-wave resonance interaction (LSRI) system with arbitrary nonlinearity coefficients, which describes the nonlinear resonance interaction of multiple short waves with a long wave in two spatial dimensions. The general multicomponent LSRI system is shown to be integrable by performing the Painlevé analysis. Then we construct the exact bright multisoliton solutions by applying the Hirota's bilinearization method and study the propagation and collision dynamics of bright solitons in detail. Particularly, we investigate the head-on and overtaking collisions of bright solitons and explore two types of energy-sharing collisions as well as standard elastic collision. We have also corroborated the obtained analytical one-soliton solution by direct numerical simulation. Also, we discuss the formation and dynamics of resonant solitons. Interestingly, we demonstrate the formation of resonant solitons admitting breather-like (localized periodic pulse train) structure and also large amplitude localized structures akin to rogue waves coexisting with solitons. For completeness, we have also obtained dark one- and two-soliton solutions and studied their dynamics briefly.

  2. Discordant U waves in the setting of hyperkalaemia.

    PubMed

    Chhabra, Lovely; Spodick, David H

    2013-07-04

    Physiological U wave genesis occurs likely secondary to either late repolarisation of Purkinje fibres, or late repolarisation of some myocardial cells and/or delayed after depolarisation of the ventricular wall occurring during ventricular filling. Hypokalaemia has a well-known association with pathological 'U wave' which actually combines with the T wave (TU complex) and results from slowing of phase 3 of the action potential with resultant electrical interaction between the three myocardial layers. U waves usually tend to disappear in the setting of hyperkalaemia. We report an unusual case where hyperkalaemia and discordant U waves coexisted. We believe that this may have occurred as a result of partial clinical adaptation of cardiac myocytes to the long-standing effects of hyperkalaemia as the patient had underlying history of chronic kidney disease. We also discuss the possible mechanisms of the U wave genesis and the importance of different U wave morphologies encountered in the real clinical practice.

  3. Nonlinear shallow ocean-wave soliton interactions on flat beaches.

    PubMed

    Ablowitz, Mark J; Baldwin, Douglas E

    2012-09-01

    Ocean waves are complex and often turbulent. While most ocean-wave interactions are essentially linear, sometimes two or more waves interact in a nonlinear way. For example, two or more waves can interact and yield waves that are much taller than the sum of the original wave heights. Most of these shallow-water nonlinear interactions look like an X or a Y or two connected Ys; at other times, several lines appear on each side of the interaction region. It was thought that such nonlinear interactions are rare events: they are not. Here we report that such nonlinear interactions occur every day, close to low tide, on two flat beaches that are about 2000 km apart. These interactions are closely related to the analytic, soliton solutions of a widely studied multidimensional nonlinear wave equation. On a much larger scale, tsunami waves can merge in similar ways.

  4. NREL Deploys Wave and Tidal Measurement Buoys | News | NREL

    Science.gov Websites

    various wave and tidal models, and in turn, reduce risks for developers. These buoys allow researchers to "better understand the limitations and errors in existing global wave models," says Kilcher using NREL, laboratory, and U.S. Department of Energy published models, the team identified likely

  5. Plasma Waves and Structures Associated with Magnetic Reconnection

    NASA Astrophysics Data System (ADS)

    Ergun, R.; Wilder, F. D.; Ahmadi, N.; Goodrich, K.; Holmes, J.; Newman, D. L.; Burch, J.; Torbert, R. B.; Le Contel, O.; Giles, B. L.; Strangeway, R. J.; Lindqvist, P. A.

    2017-12-01

    Space observations of magnetic reconnection indicate a variety of plasma wave modes and structures in the vicinity of the electron diffusion region including electromagnetic whistler waves, quasi-electrostatic whistler waves, electron phase-space holes, double layers, electron acoustic waves, lower hybrid waves, upper hybrid waves, and electromagnetic drift waves. These waves and plasma structures are seen in magnetotail reconnection and subsolar reconnection. The MMS mission has the unique ability to unequivocally identify the electron diffusion region and distinguish waves in the EDR from those in the extended separatrix. Such a distinction is critical since some of the observed waves may be involved the reconnection process while others may result from subsequent or associated events and do not directly influence the reconnection process. For example, some of the largest amplitude (> 100 mV/m) electrostatic waves have been identified as electron acoustic waves and upper hybrid waves. These waves are likely generated as a result of reconnection and do not appear to strongly influence the reconnection process. On the other hand, large-amplitude electrostatic whistler waves have been observed very near the X-line, are seen in simulations, and may be participating in reconnection physics. Electromagnetic drift waves almost always appear in cases of asymmetric reconnection and may lead to a more turbulent process. We summarize wave observations by MMS and discuss the relative their possible role in magnetic reconnection physics, concentrating on recent magnetotail observations.

  6. Early effects of extracorporeal shock wave treatment on osteoblast-like cells: a comparative study between electromagnetic and electrohydraulic devices.

    PubMed

    Martini, Lucia; Giavaresi, Gianluca; Fini, Milena; Borsari, Veronica; Torricelli, Paola; Giardino, Roberto

    2006-11-01

    Extracorporeal shockwave therapy (ESWT) has been increasingly applied to treat orthopedic and musculoskeletal pathologies. ESWT involves mechanical perturbations that, as with other physical therapies, can result in mechanical stimuli to a large number of cells, including bone cells. The aim of this study was to evaluate the effects of shock waves on osteoblast-like cells (MG63) when using two different generators of shock waves (electrohydraulic and electromagnetic devices), in terms of cell damage, cell viability, osteogenic phenotype expression, and cytokine production. MG63 cells were suspended in 1.5 mL screw-cap cryotubes (1 x 10 cells/mL), containing phosphate buffer solution (PBS), which were maintained at 37 degrees C during all the experimental times. Two levels of energy flux density (EFD) were evaluated for each device: 0.15 to 0.18 mJ/mm2 and 0.40 mJ/mm2. Cells were then cultivated for 72 hours starting from a concentration of 1 x 10 cells/mL, and biological activity and viability were evaluated 24 and 72 hours after treatment. The results obtained demonstrate that the factors most affecting osteoblast activity involve both the device and the level of EFD selected, and they must be considered all together. The use of the electromagnetic device and a level of EFD lower than 0.40 mJ/mm2 would appear to induce fewer immediate cytodestructive effects and better stimulate subsequent proliferation and the synthetic activity of MG63.

  7. Mach-like capillary-gravity wakes.

    PubMed

    Moisy, Frédéric; Rabaud, Marc

    2014-08-01

    We determine experimentally the angle α of maximum wave amplitude in the far-field wake behind a vertical surface-piercing cylinder translated at constant velocity U for Bond numbers Bo(D)=D/λ(c) ranging between 0.1 and 4.2, where D is the cylinder diameter and λ(c) the capillary length. In all cases the wake angle is found to follow a Mach-like law at large velocity, α∼U(-1), but with different prefactors depending on the value of Bo(D). For small Bo(D) (large capillary effects), the wake angle approximately follows the law α≃c(g,min)/U, where c(g,min) is the minimum group velocity of capillary-gravity waves. For larger Bo(D) (weak capillary effects), we recover a law α∼√[gD]/U similar to that found for ship wakes at large velocity [Rabaud and Moisy, Phys. Rev. Lett. 110, 214503 (2013)]. Using the general property of dispersive waves that the characteristic wavelength of the wave packet emitted by a disturbance is of order of the disturbance size, we propose a simple model that describes the transition between these two Mach-like regimes as the Bond number is varied. We show that the new capillary law α≃c(g,min)/U originates from the presence of a capillary cusp angle (distinct from the usual gravity cusp angle), along which the energy radiated by the disturbance accumulates for Bond numbers of order of unity. This model, complemented by numerical simulations of the surface elevation induced by a moving Gaussian pressure disturbance, is in qualitative agreement with experimental measurements.

  8. One-Hertz Waves at Mars: MAVEN Observations

    NASA Astrophysics Data System (ADS)

    Ruhunusiri, Suranga; Halekas, J. S.; Espley, J. R.; Eparvier, F.; Brain, D.; Mazelle, C.; Harada, Y.; DiBraccio, G. A.; Thiemann, E. M. B.; Larson, D. E.; Mitchell, D. L.; Jakosky, B. M.; Sulaiman, A. H.

    2018-05-01

    We perform a survey of 1-Hz waves at Mars utilizing Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft observations for a Martian year. We find that the 1-Hz wave occurrence rate shows an apparent variation caused by masking of the waves by background turbulence during the times when the background turbulence levels are high. To correct for this turbulence masking, we select waves that occur in time intervals where the background turbulence levels are low. We find that the extreme ultraviolet flux does not affect the wave occurrence rate significantly, suggesting that the newly born pickup ions originating in the Mars's exosphere contribute minimally to the 1-Hz wave generation. We find that the wave occurrence rates are higher for low Mach numbers and low beta values than for high Mach numbers and high beta values. Further, we find that a high percentage of 1-Hz waves satisfy the group-standing condition, which suggests that a high percentage of the waves seen as monochromatic waves in the spacecraft frame can be broadband waves in the solar wind frame that have group velocities nearly equal and opposite to the solar wind velocity. We infer that the wave occurrence rate trends with the Mach number and proton beta are a consequence of how the Mach numbers and beta values influence the wave generation and damping or how those parameters affect the group-standing condition. Finally, we find that the 1-Hz waves are equally likely to be found in both the quasi-parallel and the quasi-perpendicular foreshock regions.

  9. Exploring long-wave infrared transmitting materials with AxBy form: First-principles gene-like studies.

    PubMed

    Du, Jia-Ren; Chen, Nian-Ke; Li, Xian-Bin; Xie, Sheng-Yi; Tian, Wei Quan; Wang, Xian-Yin; Tu, Hai-Ling; Sun, Hong-Bo

    2016-02-23

    Long-wave infrared (8-12 μm) transmitting materials play critical roles in space science and electronic science. However, the paradox between their mechanical strength and infrared transmitting performance seriously prohibits their applications in harsh external environment. From the experimental view, searching a good window material compatible with both properties is a vast trail-and-error engineering project, which is not readily achieved efficiently. In this work, we propose a very simple and efficient method to explore potential infrared window materials with suitable mechanical property by first-principles gene-like searching. Two hundred and fifty-three potential materials are evaluated to find their bulk modulus (for mechanical performance) and phonon vibrational frequency (for optical performance). Seven new potential candidates are selected, namely TiSe, TiS, MgS, CdF2, HgF2, CdO, and SrO. Especially, the performances of TiS and CdF2 can be comparable to that of the most popular commercial ZnS at high temperature. Finally, we propose possible ranges of infrared transmission for halogen, chalcogen and nitrogen compounds respectively to guide further exploration. The present strategy to explore IR window materials can significantly speed up the new development progress. The same idea can be used for other material rapid searching towards special functions and applications.

  10. Near-Inertial Internal Gravity Waves in the Ocean.

    PubMed

    Alford, Matthew H; MacKinnon, Jennifer A; Simmons, Harper L; Nash, Jonathan D

    2016-01-01

    We review the physics of near-inertial waves (NIWs) in the ocean and the observations, theory, and models that have provided our present knowledge. NIWs appear nearly everywhere in the ocean as a spectral peak at and just above the local inertial period f, and the longest vertical wavelengths can propagate at least hundreds of kilometers toward the equator from their source regions; shorter vertical wavelengths do not travel as far and do not contain as much energy, but lead to turbulent mixing owing to their high shear. NIWs are generated by a variety of mechanisms, including the wind, nonlinear interactions with waves of other frequencies, lee waves over bottom topography, and geostrophic adjustment; the partition among these is not known, although the wind is likely the most important. NIWs likely interact strongly with mesoscale and submesoscale motions, in ways that are just beginning to be understood.

  11. Status of quarkonia-like negative and positive parity states in a relativistic confinement scheme

    NASA Astrophysics Data System (ADS)

    Bhavsar, Tanvi; Shah, Manan; Vinodkumar, P. C.

    2018-03-01

    Properties of quarkonia-like states in the charm and bottom sector have been studied in the frame work of relativistic Dirac formalism with a linear confinement potential. We have computed the mass spectroscopy and decay properties (vector decay constant and leptonic decay width) of several quarkonia-like states. The present study is also intended to identify some of the unexplained states as mixed P-wave and mixed S-D-wave states of charmonia and bottomonia. The results indicate that the X(4140) state can be an admixture of two P states of charmonium. And the charmonium-like states X(4630) and X(4660) are the admixed state of S-D-waves. Similarly, the X(10610) state recently reported by Belle II can be mixed P-states of bottomonium. In the relativistic framework we have computed the vector decay constant and the leptonic decay width for S wave charmonium and bottomonium. The leptonic decay widths for the J^{PC} = 1^{-} mixed states are also predicted. Further, both the masses and the leptonic decay width are considered for the identification of the quarkonia-like states.

  12. Subthalamic Nucleus Visualization on Routine Clinical Preoperative MRI Scans: A Retrospective Study of Clinical and Image Characteristics Predicting Its Visualization.

    PubMed

    Ranjan, Manish; Boutet, Alexandre; Xu, David S; Lozano, Christopher S; Kumar, Rajeev; Fasano, Alfonso; Kucharczyk, Walter; Lozano, Andres M

    2018-05-30

    The visualization of the subthalamic nucleus (STN) on magnetic resonance imaging (MRI) is variable. Studies of the contribution of patient-related factors and intrinsic brain volumetrics to STN visualization have not been reported previously. To assess the visualization of the STN during deep brain stimulation (DBS) surgery in a clinical setting. Eighty-two patients undergoing pre-operative MRI to plan for STN DBS for Parkinson disease were retrospectively studied. The visualization of the STN and its borders was assessed and scored by 3 independent observers using a 4-point ordinal scale (from 0 = not seen to 3 = excellent visualization). This measure was then correlated with the patients' clinical information and brain volumes. The mean STN visualization scores were 1.68 and 1.63 for the right and left STN, respectively, with a good interobserver reliability (intraclass correlation coefficient: 0.744). Older age and decreased white matter volume were negatively correlated with STN visualization (p < 0.05). STN visualization is only fair to good on routine MRI with good concordance of interindividual rating. Advancing age and decreased white matter are associated with poor visualization of the STN. Knowledge about factors contributing to poor visualization of the STN could alert a surgeon to modify the imaging strategy to optimize surgical targeting. © 2018 S. Karger AG, Basel.

  13. Effect of subthalamic nucleus stimulation during exercise on the mesolimbocortical dopaminergic region in Parkinson's disease: a positron emission tomography study.

    PubMed

    Nozaki, Takao; Sugiyama, Kenji; Yagi, Shunsuke; Yoshikawa, Etsuji; Kanno, Toshihiko; Asakawa, Tetsuya; Ito, Tae; Terada, Tatsuhiro; Namba, Hiroki; Ouchi, Yasuomi

    2013-03-01

    To elucidate the dynamic effects of deep brain stimulation (DBS) in the subthalamic nucleus (STN) during activity on the dopaminergic system, 12 PD patients who had STN-DBS operations at least 1 month prior, underwent two positron emission tomography scans during right-foot movement in DBS-off and DBS-on conditions. To quantify motor performance changes, the motion speed and mobility angle of the foot at the ankle were measured twice. Estimations of the binding potential of [(11)C]raclopride (BP(ND)) were based on the Logan plot method. Significant motor recovery was found in the DBS-on condition. The STN-DBS during exercise significantly reduced the [(11)C]raclopride BP(ND) in the caudate and the nucleus accumbens (NA), but not in the dorsal or ventral putamen. The magnitude of dopamine release in the NA correlated negatively with the magnitude of motor load, indicating that STN-DBS facilitated motor behavior more smoothly and at less expense to dopamine neurons in the region. The lack of dopamine release in the putamen and the significant dopamine release in the ventromedial striatum by STN-DBS during exercise indicated dopaminergic activation occurring in the motivational circuit during action, suggesting a compensatory functional activation of the motor loop from the nonmotor to the motor loop system.

  14. Atlas-Independent, Electrophysiological Mapping of the Optimal Locus of Subthalamic Deep Brain Stimulation for the Motor Symptoms of Parkinson Disease.

    PubMed

    Conrad, Erin C; Mossner, James M; Chou, Kelvin L; Patil, Parag G

    2018-05-23

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms of Parkinson disease (PD). However, motor outcomes can be variable, perhaps due to inconsistent positioning of the active contact relative to an unknown optimal locus of stimulation. Here, we determine the optimal locus of STN stimulation in a geometrically unconstrained, mathematically precise, and atlas-independent manner, using Unified Parkinson Disease Rating Scale (UPDRS) motor outcomes and an electrophysiological neuronal stimulation model. In 20 patients with PD, we mapped motor improvement to active electrode location, relative to the individual, directly MRI-visualized STN. Our analysis included a novel, unconstrained and computational electrical-field model of neuronal activation to estimate the optimal locus of DBS. We mapped the optimal locus to a tightly defined ovoid region 0.49 mm lateral, 0.88 mm posterior, and 2.63 mm dorsal to the anatomical midpoint of the STN. On average, this locus is 11.75 lateral, 1.84 mm posterior, and 1.08 mm ventral to the mid-commissural point. Our novel, atlas-independent method reveals a single, ovoid optimal locus of stimulation in STN DBS for PD. The methodology, here applied to UPDRS and PD, is generalizable to atlas-independent mapping of other motor and non-motor effects of DBS. © 2018 S. Karger AG, Basel.

  15. Battery Longevity Comparison of Two Commonly Available Dual Channel Implantable Pulse Generators Used for Subthalamic Nucleus Stimulation in Parkinson's Disease.

    PubMed

    Fisher, Benjamin; Kausar, Jamilla; Garratt, Hayley; Hodson, James; White, Anwen; Ughratdar, Ismail; Mitchell, Rosalind

    2018-06-19

    Deep brain stimulation for Parkinson's disease (PD) utilises an implantable pulse generator (IPG) whose finite lifespan in non-rechargeable systems necessitates their periodic replacement. We wish to determine if there is any significant difference in longevity of 2 commonly used IPG systems; the Medtronic Kinetra, and the Medtronic Activa Primary Cell (PC), which has come to replace it. All patients with bilateral Subthalamic Nucleus stimulators for PD performed in our centre were included. Battery life was then assessed using a Kaplan-Meier approach and comparisons between the Kinetra and Activa PC batteries were performed using log-rank tests. Complete data was available for 183 patients. There was a significant difference in the average battery duration with an estimated median battery life in the Kinetra cohort of 6.6 years (95% CI 6.4-6.7), compared to 4.5 years (95% CI 4.4-4.5) in the Activa PC cohort (p < 0.001). The Activa PC IPG demonstrates a significantly reduced battery life of 2.1 years, with a median battery life of 4.5 years in comparison to 6.6 years in the Kinetra IPG. Future technology developments should therefore be focused on improving the battery life of the newer IPG systems. © 2018 S. Karger AG, Basel.

  16. Transverse Wave Induced Kelvin–Helmholtz Rolls in Spicules

    NASA Astrophysics Data System (ADS)

    Antolin, P.; Schmit, D.; Pereira, T. M. D.; De Pontieu, B.; De Moortel, I.

    2018-03-01

    In addition to their jet-like dynamic behavior, spicules usually exhibit strong transverse speeds, multi-stranded structure, and heating from chromospheric to transition region temperatures. In this work we first analyze Hinode and IRIS observations of spicules and find different behaviors in terms of their Doppler velocity evolution and collective motion of their sub-structure. Some have a Doppler shift sign change that is rather fixed along the spicule axis, and lack coherence in the oscillatory motion of strand-like structure, matching rotation models, or long-wavelength torsional Alfvén waves. Others exhibit a Doppler shift sign change at maximum displacement and coherent motion of their strands, suggesting a collective magnetohydrodynamic (MHD) wave. By comparing with an idealized 3D MHD simulation combined with radiative transfer modeling, we analyze the role of transverse MHD waves and associated instabilities in spicule-like features. We find that transverse wave induced Kelvin–Helmholtz (TWIKH) rolls lead to coherence of strand-like structure in imaging and spectral maps, as seen in some observations. The rapid transverse dynamics and the density and temperature gradients at the spicule boundary lead to ring-shaped Mg II k and Ca II H source functions in the transverse cross-section, potentially allowing IRIS to capture the Kelvin–Helmholtz instability dynamics. Twists and currents propagate along the spicule at Alfvénic speeds, and the temperature variations within TWIKH rolls, produce the sudden appearance/disappearance of strands seen in Doppler velocity and in Ca II H intensity. However, only a mild intensity increase in higher-temperature lines is obtained, suggesting there is an additional heating mechanism at work in spicules.

  17. Shock-like haemodynamic responses induced in the primary visual cortex by moving visual stimuli

    PubMed Central

    Robinson, P. A.

    2016-01-01

    It is shown that recently discovered haemodynamic waves can form shock-like fronts when driven by stimuli that excite the cortex in a patch that moves faster than the haemodynamic wave velocity. If stimuli are chosen in order to induce shock-like behaviour, the resulting blood oxygen level-dependent (BOLD) response is enhanced, thereby improving the signal to noise ratio of measurements made with functional magnetic resonance imaging. A spatio-temporal haemodynamic model is extended to calculate the BOLD response and determine the main properties of waves induced by moving stimuli. From this, the optimal conditions for stimulating shock-like responses are determined, and ways of inducing these responses in experiments are demonstrated in a pilot study. PMID:27974572

  18. Future heat waves and surface ozone

    NASA Astrophysics Data System (ADS)

    Meehl, Gerald A.; Tebaldi, Claudia; Tilmes, Simone; Lamarque, Jean-Francois; Bates, Susan; Pendergrass, Angeline; Lombardozzi, Danica

    2018-06-01

    A global Earth system model is used to study the relationship between heat waves and surface ozone levels over land areas around the world that could experience either large decreases or little change in future ozone precursor emissions. The model is driven by emissions of greenhouse gases and ozone precursors from a medium-high emission scenario (Representative Concentration Pathway 6.0–RCP6.0) and is compared to an experiment with anthropogenic ozone precursor emissions fixed at 2005 levels. With ongoing increases in greenhouse gases and corresponding increases in average temperature in both experiments, heat waves are projected to become more intense over most global land areas (greater maximum temperatures during heat waves). However, surface ozone concentrations on future heat wave days decrease proportionately more than on non-heat wave days in areas where ozone precursors are prescribed to decrease in RCP6.0 (e.g. most of North America and Europe), while surface ozone concentrations in heat waves increase in areas where ozone precursors either increase or have little change (e.g. central Asia, the Mideast, northern Africa). In the stabilized ozone precursor experiment, surface ozone concentrations increase on future heat wave days compared to non-heat wave days in most regions except in areas where there is ozone suppression that contributes to decreases in ozone in future heat waves. This is likely associated with effects of changes in isoprene emissions at high temperatures (e.g. west coast and southeastern North America, eastern Europe).

  19. Nigral stimulation for resistant axial motor impairment in Parkinson’s disease? A randomized controlled trial

    PubMed Central

    Walach, Margarete; Meisner, Christoph; Fritz, Melanie; Scholten, Marlieke; Breit, Sorin; Plewnia, Christian; Bender, Benjamin; Gharabaghi, Alireza; Wächter, Tobias

    2013-01-01

    Gait and balance disturbances typically emerge in advanced Parkinson’s disease with generally limited response to dopaminergic medication and subthalamic nucleus deep brain stimulation. Therefore, advanced programming with interleaved pulses was put forward to introduce concomittant nigral stimulation on caudal contacts of a subthalamic lead. Here, we hypothesized that the combined stimulation of subthalamic nucleus and substantia nigra pars reticulata improves axial symptoms compared with standard subthalamic nucleus stimulation. Twelve patients were enrolled in this 2 × 2 cross-over double-blind randomized controlled clinical trial and both the safety and efficacy of combined subthalamic nucleus and substantia nigra pars reticulata stimulation were evaluated compared with standard subthalamic nucleus stimulation. The primary outcome measure was the change of a broad-scaled cumulative axial Unified Parkinson’s Disease Rating Scale score (Scale II items 13–15, Scale III items 27–31) at ‘3-week follow-up’. Secondary outcome measures specifically addressed freezing of gait, balance, quality of life, non-motor symptoms and neuropsychiatric symptoms. For the primary outcome measure no statistically significant improvement was observed for combined subthalamic nucleus and substantia nigra pars reticulata stimulation at the ‘3-week follow-up’. The secondary endpoints, however, revealed that the combined stimulation of subthalamic nucleus and substantia nigra pars reticulata might specifically improve freezing of gait, whereas balance impairment remained unchanged. The combined stimulation of subthalamic nucleus and substantia nigra pars reticulata was safe, and of note, no clinically relevant neuropsychiatric adverse effect was observed. Patients treated with subthalamic nucleus and substantia nigra pars reticulata stimulation revealed no ‘global’ effect on axial motor domains. However, this study opens the perspective that concomittant stimulation

  20. Nigral stimulation for resistant axial motor impairment in Parkinson's disease? A randomized controlled trial.

    PubMed

    Weiss, Daniel; Walach, Margarete; Meisner, Christoph; Fritz, Melanie; Scholten, Marlieke; Breit, Sorin; Plewnia, Christian; Bender, Benjamin; Gharabaghi, Alireza; Wächter, Tobias; Krüger, Rejko

    2013-07-01

    Gait and balance disturbances typically emerge in advanced Parkinson's disease with generally limited response to dopaminergic medication and subthalamic nucleus deep brain stimulation. Therefore, advanced programming with interleaved pulses was put forward to introduce concomittant nigral stimulation on caudal contacts of a subthalamic lead. Here, we hypothesized that the combined stimulation of subthalamic nucleus and substantia nigra pars reticulata improves axial symptoms compared with standard subthalamic nucleus stimulation. Twelve patients were enrolled in this 2 × 2 cross-over double-blind randomized controlled clinical trial and both the safety and efficacy of combined subthalamic nucleus and substantia nigra pars reticulata stimulation were evaluated compared with standard subthalamic nucleus stimulation. The primary outcome measure was the change of a broad-scaled cumulative axial Unified Parkinson's Disease Rating Scale score (Scale II items 13-15, Scale III items 27-31) at '3-week follow-up'. Secondary outcome measures specifically addressed freezing of gait, balance, quality of life, non-motor symptoms and neuropsychiatric symptoms. For the primary outcome measure no statistically significant improvement was observed for combined subthalamic nucleus and substantia nigra pars reticulata stimulation at the '3-week follow-up'. The secondary endpoints, however, revealed that the combined stimulation of subthalamic nucleus and substantia nigra pars reticulata might specifically improve freezing of gait, whereas balance impairment remained unchanged. The combined stimulation of subthalamic nucleus and substantia nigra pars reticulata was safe, and of note, no clinically relevant neuropsychiatric adverse effect was observed. Patients treated with subthalamic nucleus and substantia nigra pars reticulata stimulation revealed no 'global' effect on axial motor domains. However, this study opens the perspective that concomittant stimulation of the substantia

  1. Spectra of KeV Protons Related to Ion-Cyclotron Wave Packets

    NASA Technical Reports Server (NTRS)

    Khazanov, G. V.; Sibeck, D. G.; Tel'Nikhin, A. A.; Kronberg, T. K.

    2017-01-01

    We use the Fokker-Planck-Kolmogorov equation to study the statistical aspects of stochastic dynamics of the radiation belt (RB) protons driven by nonlinear electromagnetic ion-cyclotron (EMIC) wave packets. We obtain the spectra of keV protons scattered by these waves that showsteeping near the gyroresonance, the signature of resonant wave-particle interaction that cannot be described by a simple power law. The most likely mechanism for proton precipitation events in RBs is shown to be nonlinear wave-particle interaction, namely, the scattering of RB protons into the loss cone by EMIC waves.

  2. The General Fishbone Like Dispersion Relation

    NASA Astrophysics Data System (ADS)

    Zonca, Fulvio

    2015-12-01

    The following sections are included: * Introduction * Motivation and outline * Fundamental equations * The collisionless gyrokinetic equation * Vorticity equation * Quasi-neutrality condition * Perpendicular Ampère's law * Studying collective modes in burning plasmas * Ideal plasma equilibrium in the low-β limit * Approximations for the energetic population * Characteristic frequencies of particle motions * Alfvén wave frequency and wavelength orderings * Applications of the general theoretical framework * The general fishbone like dispersion relation * Properties of the fishbone like dispersion relation * Derivation of the fishbone like dispersion relation * Special cases of the fishbone like dispersion relation * Toroidal Alfvén Eigenmodes (TAE) * Alfvén Cascades * Summary and discussions * Acknowledgments * References

  3. On possible plume-guided seismic waves

    USGS Publications Warehouse

    Julian, B.R.; Evans, J.R.

    2010-01-01

    Hypothetical thermal plumes in the Earth's mantle are expected to have low seismic-wave speeds and thus would support the propagation of guided elastic waves analogous to fault-zone guided seismic waves, fiber-optic waves, and acoustic waves in the oceanic SOund Fixing And Ranging channel. Plume-guided waves would be insensitive to geometric complexities in the wave guide, and their dispersion would make them distinctive on seismograms and would provide information about wave-guide structure that would complement seismic tomography. Detecting such waves would constitute strong evidence of a new kind for the existence of plumes. A cylindrical channel embedded in an infinite medium supports two classes of axially symmetric elastic-wave modes, torsional and longitudinal-radial. Torsional modes have rectilinear particle motion tangent to the cylinder surface. Longitudinal-radial modes have elliptical particle motion in planes that include the cylinder axis, with retrograde motion near the axis. The direction of elliptical particle motion reverses with distance from the axis: once for the fundamental mode, twice for the first overtone, and so on. Each mode exists only above its cut-off frequency, where the phase and group speeds equal the shear-wave speed in the infinite medium. At high frequencies, both speeds approach the shear-wave speed in the channel. All modes have minima in their group speeds, which produce Airy phases on seismograms. For shear wave-speed contrasts of a few percent, thought to be realistic for thermal plumes in the Earth, the largest signals are inversely dispersed and have dominant frequencies of about 0.1-1 Hz and durations of 15-30 sec. There are at least two possible sources of observable plume waves: (1) the intersection of mantle plumes with high-amplitude core-phase caustics in the deep mantle; and (2) ScS-like reflection at the core-mantle boundary of downward-propagating guided waves. The widespread recent deployment of broadband

  4. Performance Benefits for Wave Rotor-Topped Gas Turbine Engines

    NASA Technical Reports Server (NTRS)

    Jones, Scott M.; Welch, Gerard E.

    1996-01-01

    The benefits of wave rotor-topping in turboshaft engines, subsonic high-bypass turbofan engines, auxiliary power units, and ground power units are evaluated. The thermodynamic cycle performance is modeled using a one-dimensional steady-state code; wave rotor performance is modeled using one-dimensional design/analysis codes. Design and off-design engine performance is calculated for baseline engines and wave rotor-topped engines, where the wave rotor acts as a high pressure spool. The wave rotor-enhanced engines are shown to have benefits in specific power and specific fuel flow over the baseline engines without increasing turbine inlet temperature. The off-design steady-state behavior of a wave rotor-topped engine is shown to be similar to a conventional engine. Mission studies are performed to quantify aircraft performance benefits for various wave rotor cycle and weight parameters. Gas turbine engine cycles most likely to benefit from wave rotor-topping are identified. Issues of practical integration and the corresponding technical challenges with various engine types are discussed.

  5. Identification and classification of very low frequency waves on a coral reef flat

    USGS Publications Warehouse

    Gawehn, Matthijs; van Dongeran, Ap; van Rooijen, Arnold; Storlazzi, Curt; Cheriton, Olivia; Reniers, Ad

    2016-01-01

    Very low frequency (VLF, 0.001–0.005 Hz) waves are important drivers of flooding of low-lying coral reef-islands. In particular, VLF wave resonance is known to drive large wave runup and subsequent overwash. Using a 5 month data set of water levels and waves collected along a cross-reef transect on Roi-Namur Island in the Republic of the Marshall Islands, the observed VLF motions were categorized into four different classes: (1) resonant, (2) (nonresonant) standing, (3) progressive-growing, and (4) progressive-dissipative waves. Each VLF class is set by the reef flat water depth and, in the case of resonance, the incident-band offshore wave period. Using an improved method to identify VLF wave resonance, we find that VLF wave resonance caused prolonged (∼0.5–6.0 h), large-amplitude water surface oscillations at the inner reef flat ranging in wave height from 0.14 to 0.83 m. It was induced by relatively long-period, grouped, incident-band waves, and occurred under both storm and nonstorm conditions. Moreover, observed resonant VLF waves had nonlinear, bore-like wave shapes, which likely have a larger impact on the shoreline than regular, sinusoidal waveforms. As an alternative technique to the commonly used Fast Fourier Transformation, we propose the Hilbert-Huang Transformation that is more computationally expensive but can capture the wave shape more accurately. This research demonstrates that understanding VLF waves on reef flats is important for evaluating coastal flooding hazards.

  6. Identification and classification of very low frequency waves on a coral reef flat

    NASA Astrophysics Data System (ADS)

    Gawehn, Matthijs; van Dongeren, Ap; van Rooijen, Arnold; Storlazzi, Curt D.; Cheriton, Olivia M.; Reniers, Ad

    2016-10-01

    Very low frequency (VLF, 0.001-0.005 Hz) waves are important drivers of flooding of low-lying coral reef-islands. In particular, VLF wave resonance is known to drive large wave runup and subsequent overwash. Using a 5 month data set of water levels and waves collected along a cross-reef transect on Roi-Namur Island in the Republic of the Marshall Islands, the observed VLF motions were categorized into four different classes: (1) resonant, (2) (nonresonant) standing, (3) progressive-growing, and (4) progressive-dissipative waves. Each VLF class is set by the reef flat water depth and, in the case of resonance, the incident-band offshore wave period. Using an improved method to identify VLF wave resonance, we find that VLF wave resonance caused prolonged (˜0.5-6.0 h), large-amplitude water surface oscillations at the inner reef flat ranging in wave height from 0.14 to 0.83 m. It was induced by relatively long-period, grouped, incident-band waves, and occurred under both storm and nonstorm conditions. Moreover, observed resonant VLF waves had nonlinear, bore-like wave shapes, which likely have a larger impact on the shoreline than regular, sinusoidal waveforms. As an alternative technique to the commonly used Fast Fourier Transformation, we propose the Hilbert-Huang Transformation that is more computationally expensive but can capture the wave shape more accurately. This research demonstrates that understanding VLF waves on reef flats is important for evaluating coastal flooding hazards.

  7. From N-WASP to WAVE: key molecules for regulation of cortical actin organization.

    PubMed

    Takenawa, Tadaomi

    2005-01-01

    We first isolated N-WASP as one of the proteins bound to Ash/Grb2 SH3 domain. This protein has a VCA region (verplorin-like, cofilin-like, acidic region) at the C-terminus, which binds to G-actin and Arp2/3 complex, and several functional domains at the N-terminus, such as WHD (WASP homology domain) and GBD/CRIB domain. N-WASP activates Arp2/3 complex-dependent actin polymerization through the VCA region, leading to filopodium formation. Next, we found WAVE1, WAVE2 and WAVE3. All these proteins have also VCA regions at C-terminal areas and induce membrane ruffle formation. To clarify the different roles of WAVE1 and WAVE2, we established WAVE1- and WAVE2-deficient mouse embryonic fibroblasts (MEFs), because these two WAVEs are expressed in MEF. When wild-type MEFs are stimulated randomly by PDGF, two types of ruffles, peripheral and dorsal, are formed. However, dorsal ruffle formation does not occurin WAVE1-deficient MEFs. In contrast, peripheral ruffle formation is diminished in WAVE2-deficient MEFs. On the other hand, in MEFs migrating towards a chemoattractant gradient, only peripheral ruffles (lamellipodia) are formed. In this migration, WAVE1-deficient MEFs still could form lamellipodia but WAVE2-deficient MEFs could not. All these data show that WAVE2 but not WAVE1 is essential for lamellipodium formation and directed migration.

  8. A surface wave reflector in Southwestern Japan

    NASA Astrophysics Data System (ADS)

    Mak, S.; Koketsu, K.; Miyake, H.; Obara, K.; Sekine, S.

    2009-12-01

    Surface waves at short periods (<35s) are affected severely by heterogeneities in the crust and the uppermost mantle. When the scale of heterogeneity is sufficiently large, its effect can be studied in a deterministic way using conventional concepts of reflection and refraction. A well-known example is surface wave refraction at continental margin. We present a case study to investigate the composition of surface wave coda in a deterministic approach. A long duration of surface wave coda with a predominant period of 20s is observed during various strong earthquakes around Japan. The coda shows an unambiguous propagation direction, implying a deterministic nature. Beamforming and particle motion analysis suggest that the surface wave later arrivals could be explained by Love wave reflections by a point reflector located at offshore southeast to Kyushu. The reflection demonstrates a seemingly incidence-independent favorable azimuth in emitting strength. In additional to beamforming, we use a new regional crustal velocity model to perform a grid-search ray-tracing with the assumption of point reflector to further constrain to location of coda generation. Because strong velocity anomalies exist near the zone of interest, we decide to use a network shortest-path ray-tracing method, instead of analytical methods like shooting and bending, to avoid the problems like convergence, shadow zone, and smooth model assumption. Two geological features are found to be related to the formation of the coda. The primary one is the intersection between the Kyushu-Palau Ridge and the Nankai Trough at offshore southeast to Kyushu (hereafter referred as "KPR-NT"), which may act as a point reflector. There is a strong Love wave phase velocity anomaly at KPR-NT but not other parts of the ridge, implying that topography is irrelevant. Rayleigh wave phase velocity does not experience a strong anomaly there, which is consistent to the absence of Rayleigh wave reflections implied by the

  9. Shear waves in inhomogeneous, compressible fluids in a gravity field.

    PubMed

    Godin, Oleg A

    2014-03-01

    While elastic solids support compressional and shear waves, waves in ideal compressible fluids are usually thought of as compressional waves. Here, a class of acoustic-gravity waves is studied in which the dilatation is identically zero, and the pressure and density remain constant in each fluid particle. These shear waves are described by an exact analytic solution of linearized hydrodynamics equations in inhomogeneous, quiescent, inviscid, compressible fluids with piecewise continuous parameters in a uniform gravity field. It is demonstrated that the shear acoustic-gravity waves also can be supported by moving fluids as well as quiescent, viscous fluids with and without thermal conductivity. Excitation of a shear-wave normal mode by a point source and the normal mode distortion in realistic environmental models are considered. The shear acoustic-gravity waves are likely to play a significant role in coupling wave processes in the ocean and atmosphere.

  10. Removing Wave Artifacts from Eddy Correlation Data

    NASA Astrophysics Data System (ADS)

    Neumann, Andreas; Brand, Andreas

    2017-04-01

    The German Wadden Sea is an extensive system of back-barrier tidal basins along the margin of the southern North Sea. Due to their high productivity and the strong retention potential of labile organic carbon high mineralization rates are expected in this system. Since the sediment bed is sandy, the oxygen fluxes across the sediment-water interface (SWI) may be enhanced by strong tidal currents as well as by wind-induced surface waves. In order to measure oxygen fluxes in-situ without disturbance of the sediment, the Eddy Correlation method (ECM) was introduced to aquatic geoscience by Berg et al. (2003). The method is based on correlating turbulent fluctuations of oxygen concentration and vertical velocity measured at high frequency above the SWI. The method integrates over spatial heterogeneities and allows the observation of total benthic oxygen fluxes in complex systems where other methods like flux chamber deployments and oxygen profile measurements in the sediment fail. Therefore, the method should also reflect effects like the enhancement of oxygen fluxes by porewater advection driven by waves and currents over sandy sediments. Unfortunately the ECM suffers from wave contamination due to stirring sensitivity of the electrodes, spatial separation between the oxygen electrode and the location of velocity measurement as well as by a tilt of the measurement setup at the deployment side. In order to correct for this wave contamination we tested the method of spectral reconstruction initially introduced by Bricker and Monismith (2007) for the determination of Reynolds-stresses in wave-affected environments. In short, this method attempts to remove the wave signal from the Power spectral densities of oxygen concentration and vertical velocity fluctuations by cutting off the wave peak in these spectra. The wave contribution to the co-spectrum between both quantities is then reconstructed by assuming that the phasing in the wave band is dominated by the waves. Based

  11. Observation of frequency cutoff for self-excited dust acoustic waves

    NASA Astrophysics Data System (ADS)

    Nosenko, V.; Zhdanov, S. K.; Morfill, G. E.; Kim, S.-H.; Heinrich, J.; Merlino, R. L.

    2009-11-01

    Complex (dusty) plasmas consist of fine solid particles suspended in a weakly ionized gas. Complex plasmas are excellent model systems to study wave phenomena down to the level of individual ``atoms''. Spontaneously excited dust acoustic waves were observed with high temporal resolution in a suspension of micron-size kaolin particles in a dc discharge in argon. Wave activity was found at frequencies as high as 400 Hz. At high wave numbers, the wave dispersion relation was acoustic-like (frequency proportional to wave number). At low wave numbers, the wave frequency did not tend to zero, but reached a cutoff frequency fc instead. The value of fc declined with distance from the anode. We propose a simple model that explains the observed cutoff by particle confinement in plasma. The existence of a cutoff frequency is very important for the propagation of waves: the waves excited above fc are propagating, and those below fc are evanescent.

  12. Effects of medication and subthalamic nucleus deep brain stimulation on tongue movements in speakers with Parkinson's disease using electropalatography: a pilot study.

    PubMed

    Hartinger, Mariam; Tripoliti, Elina; Hardcastle, William J; Limousin, Patricia

    2011-03-01

    Parkinson's disease (PD) affects speech in the majority of patients. Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in reducing tremor and rigidity. However, its effect on speech is variable. The aim of this pilot study was to quantify the effects of bilateral STN-DBS and medication on articulation, using electropalatography (EPG). Two patients, PT1 and PT2, were studied under four conditions: on and off medication and ON and OFF stimulation. The EPG protocol consisted of a number of target words with alveolar and velar stops, repeated 10 times in random order. The motor part III of the Unified Parkinson Disease Rating Scale (UPDRS) indicated significantly improved motor scores in the ON stimulation condition in both patients. However, PT1's articulation patterns deteriorated with stimulation whereas PT2 showed improving articulatory accuracy in the same condition. The results revealed different effects of stimulation and medication on articulation particularly with regard to timing. The study quantified less articulatory undershoot for velar stops in comparison to alveolars. Furthermore, the findings provided preliminary evidence that stimulation with medication has a more detrimental effect on articulation than stimulation without medication.

  13. VHF electromagnetic wave propagation

    NASA Astrophysics Data System (ADS)

    Gole, P.

    Theoretical and experimental study of large-scale VHF propagation characteristics is presented. Certain phenomena that are difficult to model, such as the effects of ground near the antenna, are examined from a purely experimental point of view. The characteristics of electromagnetic waves over a spherical surface and through a medium having a certain refractive index, such as is the case for waves propagated over the earth's surface, are analytically described. Two mathematical models are used, one for the case of the receiver being within the radioelectric horizon of the transmitter and the other for when it is not. Propagation phenomena likely to increase the false alarm probability of an air surveillance radar are briefly considered.

  14. Quantization of Time-Like Energy for Wave Maps into Spheres

    NASA Astrophysics Data System (ADS)

    Grinis, Roland

    2017-06-01

    In this article we consider large energy wave maps in dimension 2+1, as in the resolution of the threshold conjecture by Sterbenz and Tataru (Commun. Math. Phys. 298(1):139-230, 2010; Commun. Math. Phys. 298(1):231-264, 2010), but more specifically into the unit Euclidean sphere S^{n-1} \\subsetRn with {n≥2}, and study further the dynamics of the sequence of wave maps that are obtained in Sterbenz and Tataru (Commun. Math. Phys. 298(1):231-264, 2010) at the final rescaling for a first, finite or infinite, time singularity. We prove that, on a suitably chosen sequence of time slices at this scaling, there is a decomposition of the map, up to an error with asymptotically vanishing energy, into a decoupled sum of rescaled solitons concentrating in the interior of the light cone and a term having asymptotically vanishing energy dispersion norm, concentrating on the null boundary and converging to a constant locally in the interior of the cone, in the energy space. Similar and stronger results have been recently obtained in the equivariant setting by several authors (Côte, Commun. Pure Appl. Math. 68(11):1946-2004, 2015; Côte, Commun. Pure Appl. Math. 69(4):609-612, 2016; Côte, Am. J. Math. 137(1):139-207, 2015; Côte et al., Am. J. Math. 137(1):209-250, 2015; Krieger, Commun. Math. Phys. 250(3):507-580, 2004), where better control on the dispersive term concentrating on the null boundary of the cone is provided, and in some cases the asymptotic decomposition is shown to hold for all time. Here, however, we do not impose any symmetry condition on the map itself and our strategy follows the one from bubbling analysis of harmonic maps into spheres in the supercritical regime due to Lin and Rivière (Ann. Math. 149(2):785-829, 1999; Duke Math. J. 111:177-193, 2002), which we make work here in the hyperbolic context of Sterbenz and Tataru (Commun. Math. Phys. 298(1), 231-264, 2010).

  15. Deep brain stimulation of the subthalamic nucleus in obsessive-compulsive disorder: Neuroanatomical and pathophysiological considerations.

    PubMed

    Mulders, A E P; Plantinga, B R; Schruers, K; Duits, A; Janssen, M L F; Ackermans, L; Leentjens, A F G; Jahanshahi, A; Temel, Y

    2016-12-01

    Obsessive-compulsive disorder (OCD) is among the most disabling chronic psychiatric disorders and has a significant negative impact on multiple domains of quality of life. For patients suffering from severe refractory OCD, deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been applied. Reviewing the literature of the last years we believe that through its central position within the cortico-basal ganglia-thalamocortical circuits, the STN has a coordinating role in decision-making and action-selection mechanisms. Dysfunctional information-processing at the level of the STN is responsible for some of the core symptoms of OCD. Research confirms an electrophysiological dysfunction in the associative and limbic (non-motor) parts of the STN. Compared to Parkinson׳s disease patients, STN neurons in OCD exhibit a lower firing rate, less frequent but longer bursts, increased burst activity in the anterior ventromedial area, an asymmetrical left-sided burst distribution, and a predominant oscillatory activity in the δ-band. Moreover, there is direct evidence for the involvement of the STN in both checking behavior and OCD symptoms, which are both related to changes in electrophysiological activity in the non-motor STN. Through a combination of mechanisms, DBS of the STN seems to interrupt the disturbed information-processing, leading to a normalization of connectivity within the cortico-basal ganglia-thalamocortical circuits and consequently to a reduction in symptoms. In conclusion, based on the STN׳s strategic position within cortico-basal ganglia-thalamocortical circuits and its involvement in action-selection mechanisms that are responsible for some of the core symptoms of OCD, the STN is a mechanism-based target for DBS in OCD. Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

  16. SPECT and PET analysis of subthalamic stimulation in Parkinson's disease: analysis using a manual segmentation.

    PubMed

    Haegelen, Claire; García-Lorenzo, Daniel; Le Jeune, Florence; Péron, Julie; Gibaud, Bernard; Riffaud, Laurent; Brassier, Gilles; Barillot, Christian; Vérin, Marc; Morandi, Xavier

    2010-03-01

    The subthalamic nucleus (STN) has become an effective target of deep-brain stimulation (DBS) in severely disabled patients with advanced Parkinson's disease (PD). Clinical studies have reported DBS-induced adverse effects on cognitive functions, mood, emotion and behavior. STN DBS seems to interfere with the limbic functions of the basal ganglia, but the limbic effects of STN DBS are controversial. We measured prospectively resting regional cerebral metabolism (rCMb) with 18-fluorodeoxyglucose and PET, and resting regional cerebral blood flow (rCBF) with HMPAO and SPECT in six patients with Parkinson's disease. We compared PET and SPECT 1 month before and 3 months after STN DBS. On cerebral MRI, 13 regions of interest (ROI) were manually delineated slice by slice in frontal and limbic lobes. We obtained mean rCBF and rCMb values for each ROI and the whole brain. We normalized rCBF and rCMB values to ones for the whole brain volume, which we compared before and following STN DBS. No significant difference emerged in the SPECT analysis. PET analysis revealed a significant decrease in rCMb following STN DBS in the superior frontal gyri and left and right dorsolateral prefrontal cortex (p < 0.05). A non-significant decrease in rCMb in the left anterior cingulate gyrus appeared following STN DBS (p = 0.075). Our prospective SPECT and PET study revealed significantly decreased glucose metabolism of the two superior frontal gyri without any attendant perfusion changes following STN DBS. These results suggest that STN DBS may change medial prefrontal function and therefore the integration of limbic information, either by disrupting emotional processes within the STN, or by hampering the normal function of a limbic circuit.

  17. Non-motor outcomes of subthalamic stimulation in Parkinson's disease depend on location of active contacts.

    PubMed

    Dafsari, Haidar Salimi; Petry-Schmelzer, Jan Niklas; Ray-Chaudhuri, K; Ashkan, Keyoumars; Weis, Luca; Dembek, Till A; Samuel, Michael; Rizos, Alexandra; Silverdale, Monty; Barbe, Michael T; Fink, Gereon R; Evans, Julian; Martinez-Martin, Pablo; Antonini, Angelo; Visser-Vandewalle, Veerle; Timmermann, Lars

    2018-03-16

    Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and non-motor symptoms (NMS) in Parkinson's disease (PD). Few studies have investigated the influence of the location of neurostimulation on NMS. To investigate the impact of active contact location on NMS in STN-DBS in PD. In this prospective, open-label, multicenter study including 50 PD patients undergoing bilateral STN-DBS, we collected NMSScale (NMSS), NMSQuestionnaire (NMSQ), Hospital Anxiety and Depression Scale (anxiety/depression, HADS-A/-D), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, motor complications, activities of daily living (ADL), and levodopa equivalent daily dose (LEDD) preoperatively and at 6 months follow-up. Changes were analyzed with Wilcoxon signed-rank/t-test and Bonferroni-correction for multiple comparisons. Although the STN was targeted visually, we employed an atlas-based approach to explore the relationship between active contact locations and DBS outcomes. Based on fused MRI/CT-images, we identified Cartesian coordinates of active contacts with patient-specific Mai-atlas standardization. We computed linear mixed-effects models with x-/y-/z-coordinates as independent, hemispheres as within-subject, and test change scores as dependent variables. NMSS, NMSQ, PDQ-8, motor examination, complications, and LEDD significantly improved at follow-up. Linear mixed-effect models showed that NMS and QoL improvement significantly depended on more medial (HADS-D, NMSS), anterior (HADS-D, NMSQ, PDQ-8), and ventral (HADS-A/-D, NMSS, PDQ-8) neurostimulation. ADL improved more in posterior, LEDD in lateral neurostimulation locations. No relationship was observed for motor examination and complications scores. Our study provides evidence that more anterior, medial, and ventral STN-DBS is significantly related to more beneficial non-motor outcomes. Copyright © 2018. Published by Elsevier Inc.

  18. Copepod Behavior Response in an Internal Wave Apparatus

    NASA Astrophysics Data System (ADS)

    Webster, D. R.; Jung, S.; Haas, K. A.

    2017-11-01

    This study is motivated to understand the bio-physical forcing in zooplankton transport in and near internal waves, where high levels of zooplankton densities have been observed in situ. A laboratory-scale internal wave apparatus was designed to create a standing internal wave for various physical arrangements that mimic conditions observed in the field. A theoretical analysis of a standing internal wave inside a two-layer stratification system including non-linear wave effects was conducted to derive the expressions for the independent variables controlling the wave motion. Focusing on a case with a density jump of 1.0 σt, a standing internal wave was generated with a clean interface and minimal mixing across the pycnocline. Spatial and frequency domain measurements of the internal wave were evaluated in the context of the theoretical analysis. Behavioral assays with a mixed population of three marine copepods were conducted in control (stagnant homogeneous fluid), stagnant density jump interface, and internal wave flow configurations. In the internal wave treatment, the copepods showed an acrobatic, orbital-like motion in and around the internal wave region (bounded by the crests and the troughs of the waves). Trajectories of passive, neutrally-buoyant particles in the internal wave flow reveal that they generally oscillate back-and-forth along fixed paths. Thus, we conclude that the looping, orbital trajectories of copepods in the region near the internal wave interface are due to animal behavior rather than passive transport.

  19. Choreatic Side Effects of Deep Brain Stimulation of the Anteromedial Subthalamic Nucleus for Treatment-Resistant Obsessive-Compulsive disorder.

    PubMed

    Mulders, Anne E P; Leentjens, Albert F G; Schruers, Koen; Duits, Annelien; Ackermans, Linda; Temel, Yasin

    2017-08-01

    Patients with treatment-resistant obsessive-compulsive disorder (OCD) are potential candidates for deep brain stimulation (DBS). The anteromedial subthalamic nucleus (STN) is among the most commonly used targets for DBS in OCD. We present a patient with a 30-year history of treatment-resistant OCD who underwent anteromedial STN-DBS. Despite a clear mood-enhancing effect, stimulation caused motor side effects, including bilateral hyperkinesia, dyskinesias, and sudden large amplitude choreatic movements of arms and legs when stimulating at voltages greater than approximately 1.5 V. DBS at lower amplitudes and at other contact points failed to result in a significant reduction of obsessions and compulsions without inducing motor side effects. Because of this limitation in programming options, we decided to reoperate and target the ventral capsule/ventral striatum (VC/VS), which resulted in a substantial reduction in key obsessive and compulsive symptoms without serious side effects. Choreatic movements and hemiballismus have previously been linked to STN dysfunction and have been incidentally reported as side effects of DBS of the dorsolateral STN in Parkinson disease (PD). However, in PD, these side effects were usually transient, and they rarely interfered with DBS programming. In our patient, the motor side effects were persistent, and they made optimal DBS programming impossible. To our knowledge, such severe and persistent motor side effects have not been described previously for anteromedial STN-DBS. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Electromagnetic drift waves dispersion for arbitrarily collisional plasmas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Wonjae, E-mail: wol023@ucsd.edu; Krasheninnikov, Sergei I., E-mail: skrash@mae.ucsd.edu; Angus, J. R.

    2015-07-15

    The impacts of the electromagnetic effects on resistive and collisionless drift waves are studied. A local linear analysis on an electromagnetic drift-kinetic equation with Bhatnagar-Gross-Krook-like collision operator demonstrates that the model is valid for describing linear growth rates of drift wave instabilities in a wide range of plasma parameters showing convergence to reference models for limiting cases. The wave-particle interactions drive collisionless drift-Alfvén wave instability in low collisionality and high beta plasma regime. The Landau resonance effects not only excite collisionless drift wave modes but also suppress high frequency electron inertia modes observed from an electromagnetic fluid model in collisionlessmore » and low beta regime. Considering ion temperature effects, it is found that the impact of finite Larmor radius effects significantly reduces the growth rate of the drift-Alfvén wave instability with synergistic effects of high beta stabilization and Landau resonance.« less

  1. Tackling psychosocial maladjustment in Parkinson's disease patients following subthalamic deep-brain stimulation: A randomised clinical trial.

    PubMed

    Flores Alves Dos Santos, Joao; Tezenas du Montcel, Sophie; Gargiulo, Marcella; Behar, Cecile; Montel, Sébastien; Hergueta, Thierry; Navarro, Soledad; Belaid, Hayat; Cloitre, Pauline; Karachi, Carine; Mallet, Luc; Welter, Marie-Laure

    2017-01-01

    Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for the motor and non-motor signs of Parkinson's disease (PD), however, psychological disorders and social maladjustment have been reported in about one third of patients after STN-DBS. We propose here a perioperative psychoeducation programme to limit such social and familial disruption. Nineteen PD patients and carers were included in a randomised single blind study. Social adjustment scale (SAS) scores from patients and carers that received the psychoeducation programme (n = 9) were compared, both 1 and 2 years after surgery, with patients and carers with usual care (n = 10). Depression, anxiety, cognitive status, apathy, coping, parkinsonian disability, quality-of-life, carers' anxiety and burden were also analysed. Seventeen patients completed the study, 2 were excluded from the final analysis because of adverse events. At 1 year, 2/7 patients with psychoeducation and 8/10 with usual care had an aggravation in at least one domain of the SAS (p = .058). At 2 years, only 1 patient with psychoeducation suffered persistent aggravated social adjustment as compared to 8 patients with usual care (p = .015). At 1 year, anxiety, depression and instrumental coping ratings improved more in the psychoeducation than in the usual care group (p = .038, p = .050 and p = .050, respectively). No significant differences were found between groups for quality of life, cognitive status, apathy or motor disability. Our results suggest that a perioperative psychoeducation programme prevents social maladjustment in PD patients following STN-DBS and improves anxiety and depression compared to usual care. These preliminary data need to be confirmed in larger studies.

  2. Movement-Related Discharge in the Macaque Globus Pallidus during High-Frequency Stimulation of the Subthalamic Nucleus

    PubMed Central

    Zimnik, Andrew J.; Nora, Gerald J.; Desmurget, Michel

    2015-01-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) has largely replaced ablative therapies for Parkinson's disease. Because of the similar efficacies of the two treatments, it has been proposed that DBS acts by creating an “informational lesion,” whereby pathologic neuronal firing patterns are replaced by low-entropy, stimulus-entrained firing patterns. The informational lesion hypothesis, in its current form, states that DBS blocks the transmission of all information from the basal ganglia, including both pathologic firing patterns and normal, task-related modulations in activity. We tested this prediction in two healthy rhesus macaques by recording single-unit spiking activity from the globus pallidus (232 neurons) while the animals completed choice reaction time reaching movements with and without STN-DBS. Despite strong effects of DBS on the activity of most pallidal cells, reach-related modulations in firing rate were equally prevalent in the DBS-on and DBS-off states. This remained true even when the analysis was restricted to cells affected significantly by DBS. In addition, the overall form and timing of perimovement modulations in firing rate were preserved between DBS-on and DBS-off states in the majority of neurons (66%). Active movement and DBS had largely additive effects on the firing rate of most neurons, indicating an orthogonal relationship in which both inputs contribute independently to the overall firing rate of pallidal neurons. These findings suggest that STN-DBS does not act as an indiscriminate informational lesion but rather as a filter that permits task-related modulations in activity while, presumably, eliminating the pathological firing associated with parkinsonism. PMID:25740526

  3. Global-scale equatorial Rossby waves as an essential component of solar internal dynamics

    NASA Astrophysics Data System (ADS)

    Löptien, Björn; Gizon, Laurent; Birch, Aaron C.; Schou, Jesper; Proxauf, Bastian; Duvall, Thomas L.; Bogart, Richard S.; Christensen, Ulrich R.

    2018-05-01

    The Sun’s complex dynamics is controlled by buoyancy and rotation in the convection zone. Large-scale flows are dominated by vortical motions1 and appear to be weaker than expected in the solar interior2. One possibility is that waves of vorticity due to the Coriolis force, known as Rossby waves3 or r modes4, remove energy from convection at the largest scales5. However, the presence of these waves in the Sun is still debated. Here, we unambiguously discover and characterize retrograde-propagating vorticity waves in the shallow subsurface layers of the Sun at azimuthal wavenumbers below 15, with the dispersion relation of textbook sectoral Rossby waves. The waves have lifetimes of several months, well-defined mode frequencies below twice the solar rotational frequency, and eigenfunctions of vorticity that peak at the equator. Rossby waves have nearly as much vorticity as the convection at the same scales, thus they are an essential component of solar dynamics. We observe a transition from turbulence-like to wave-like dynamics around the Rhines scale6 of angular wavenumber of approximately 20. This transition might provide an explanation for the puzzling deficit of kinetic energy at the largest spatial scales.

  4. Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats.

    PubMed

    Marin, C; Aguilar, E; Rodríguez-Oroz, M C; Bartoszyk, G D; Obeso, J A

    2009-06-01

    Dyskinesia affects the majority of levodopa-treated parkinsonian patients within 5-10 years of treatment with levodopa. Clinical and preclinical observations suggest that an increase in serotoninergic transmission can contribute to the appearance of dyskinesias. It is thus conceivable that a modulation of synaptic dopamine (DA) levels induced by the inhibition of serotonin (5-HT) release, as a consequence of 5-HT(1A) agonists administration, might alleviate dyskinesias. Since 5-HT(1A) receptors are expressed in the subthalamic nucleus (STN), the aim of the present study was to assess the effect of the intrasubthalamic administration of sarizotan, a compound with full 5-HT(1A) agonist properties, on levodopa-induced dyskinesias in the 6-hydroxydopamine (6-OHDA) model of parkinsonism. Male Sprague-Dawley rats received a unilateral 6-OHDA administration in the nigrostriatal pathway. A test of apomorphine was performed to evaluate dopamine depletion. One week later, a cannula was implanted in the STN. Animals were treated with levodopa (6 mg/kg, i.p., twice at day) for 22 consecutive days. On day 23, several doses (1 ng, 10 ng, or 1 microg) of sarizotan were administered through the cannula to the STN. The higher doses of sarizotan effectively attenuated all levodopa-induced dyskinesias including axial, limb, and orolingual subtypes. These results suggest that the STN is a target structure for the antidyskinetic action of sarizotan and indicate that drug-mediated modulation of STN activity may be an alternative option for the treatment of levodopa-induced dyskinesias in Parkinson's disease.

  5. Elastic and viscoelastic mechanical properties of brain tissues on the implanting trajectory of sub-thalamic nucleus stimulation.

    PubMed

    Li, Yan; Deng, Jianxin; Zhou, Jun; Li, Xueen

    2016-11-01

    Corresponding to pre-puncture and post-puncture insertion, elastic and viscoelastic mechanical properties of brain tissues on the implanting trajectory of sub-thalamic nucleus stimulation are investigated, respectively. Elastic mechanical properties in pre-puncture are investigated through pre-puncture needle insertion experiments using whole porcine brains. A linear polynomial and a second order polynomial are fitted to the average insertion force in pre-puncture. The Young's modulus in pre-puncture is calculated from the slope of the two fittings. Viscoelastic mechanical properties of brain tissues in post-puncture insertion are investigated through indentation stress relaxation tests for six interested regions along a planned trajectory. A linear viscoelastic model with a Prony series approximation is fitted to the average load trace of each region using Boltzmann hereditary integral. Shear relaxation moduli of each region are calculated using the parameters of the Prony series approximation. The results show that, in pre-puncture insertion, needle force almost increases linearly with needle displacement. Both fitting lines can perfectly fit the average insertion force. The Young's moduli calculated from the slope of the two fittings are worthy of trust to model linearly or nonlinearly instantaneous elastic responses of brain tissues, respectively. In post-puncture insertion, both region and time significantly affect the viscoelastic behaviors. Six tested regions can be classified into three categories in stiffness. Shear relaxation moduli decay dramatically in short time scales but equilibrium is never truly achieved. The regional and temporal viscoelastic mechanical properties in post-puncture insertion are valuable for guiding probe insertion into each region on the implanting trajectory.

  6. Voice Tremor Outcomes of Subthalamic Nucleus and Zona Incerta Deep Brain Stimulation in Patients With Parkinson Disease.

    PubMed

    Karlsson, Fredrik; Malinova, Elin; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; Nordh, Erik

    2018-01-17

    We aimed to study the effect of deep brain stimulation (DBS) in the subthalamic nucleus (STN) and caudal zona incerta (cZi) on level of perceived voice tremor in patients with Parkinson disease (PD). This is a prospective nonrandomized design with consecutive patients. Perceived voice tremor was assessed in patients with PD having received either STN-DBS (8 patients, 5 bilateral and 3 unilateral, aged 43.1-73.6 years; median = 61.2 years) or cZi-DBS (14 bilateral patients, aged 39.0-71.9 years; median = 56.6 years) 12 months before the assessment. Sustained vowels that were produced OFF and ON stimulation (with simultaneous l-DOPA medication) were assessed perceptually in terms of voice tremor by two raters on a four-point rating scale. The assessments were repeated five times per sample and rated in a blinded and randomized procedure. Three out of the 22 patients (13%) were concluded to have voice tremor OFF stimulation. Patients with PD with STN-DBS showed mild levels of perceived voice tremor OFF stimulation and a group level improvement. Patients with moderate/severe perceived voice tremor and cZi-DBS showed marked improvements, but there was no overall group effect. Six patients with cZi-DBS showed small increases in perceived voice tremor severity. STN-DBS decreased perceived voice tremor on a group level. cZi-DBS decreased perceived voice tremor in patients with PD with moderate to severe preoperative levels of the symptom. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  7. A Computerized Microelectrode Recording to Magnetic Resonance Imaging Mapping System for Subthalamic Nucleus Deep Brain Stimulation Surgery.

    PubMed

    Dodani, Sunjay S; Lu, Charles W; Aldridge, J Wayne; Chou, Kelvin L; Patil, Parag G

    2018-06-01

    Accurate electrode placement is critical to the success of deep brain stimulation (DBS) surgery. Suboptimal targeting may arise from poor initial target localization, frame-based targeting error, or intraoperative brain shift. These uncertainties can make DBS surgery challenging. To develop a computerized system to guide subthalamic nucleus (STN) DBS electrode localization and to estimate the trajectory of intraoperative microelectrode recording (MER) on magnetic resonance (MR) images algorithmically during DBS surgery. Our method is based upon the relationship between the high-frequency band (HFB; 500-2000 Hz) signal from MER and voxel intensity on MR images. The HFB profile along an MER trajectory recorded during surgery is compared to voxel intensity profiles along many potential trajectories in the region of the surgically planned trajectory. From these comparisons of HFB recordings and potential trajectories, an estimate of the MER trajectory is calculated. This calculated trajectory is then compared to actual trajectory, as estimated by postoperative high-resolution computed tomography. We compared 20 planned, calculated, and actual trajectories in 13 patients who underwent STN DBS surgery. Targeting errors for our calculated trajectories (2.33 mm ± 0.2 mm) were significantly less than errors for surgically planned trajectories (2.83 mm ± 0.2 mm; P = .01), improving targeting prediction in 70% of individual cases (14/20). Moreover, in 4 of 4 initial MER trajectories that missed the STN, our method correctly indicated the required direction of targeting adjustment for the DBS lead to intersect the STN. A computer-based algorithm simultaneously utilizing MER and MR information potentially eases electrode localization during STN DBS surgery.

  8. Functional Neuroimaging of Spike-Wave Seizures

    PubMed Central

    Motelow, Joshua E.; Blumenfeld, Hal

    2013-01-01

    Generalized spike-wave seizures are typically brief events associated with dynamic changes in brain physiology, metabolism, and behavior. Functional magnetic resonance imaging (fMRI) provides a relatively high spatio-temporal resolution method for imaging cortical-subcortical network activity during spike-wave seizures. Patients with spike-wave seizures often have episodes of staring and unresponsiveness which interfere with normal behavior. Results from human fMRI studies suggest that spike-wave seizures disrupt specific networks in the thalamus and fronto-parietal association cortex which are critical for normal attentive consciousness. However, the neuronal activity underlying imaging changes seen during fMRI is not well understood, particularly in abnormal conditions such as seizures. Animal models have begun to provide important fundamental insights into the neuronal basis for fMRI changes during spike-wave activity. Work from these models including both fMRI and direct neuronal recordings suggest that, like in humans, specific cortical-subcortical networks are involved in spike-wave, while other regions are spared. Regions showing fMRI increases demonstrate correlated increases in neuronal activity in animal models. The mechanisms of fMRI decreases in spike-wave will require further investigation. A better understanding of the specific brain regions involved in generating spike-wave seizures may help guide efforts to develop targeted therapies aimed at preventing or reversing abnormal excitability in these brain regions, ultimately leading to a cure for this disorder. PMID:18839093

  9. Instability of a planar expansion wave.

    PubMed

    Velikovich, A L; Zalesak, S T; Metzler, N; Wouchuk, J G

    2005-10-01

    An expansion wave is produced when an incident shock wave interacts with a surface separating a fluid from a vacuum. Such an interaction starts the feedout process that transfers perturbations from the rippled inner (rear) to the outer (front) surface of a target in inertial confinement fusion. Being essentially a standing sonic wave superimposed on a centered expansion wave, a rippled expansion wave in an ideal gas, like a rippled shock wave, typically produces decaying oscillations of all fluid variables. Its behavior, however, is different at large and small values of the adiabatic exponent gamma. At gamma > 3, the mass modulation amplitude delta(m) in a rippled expansion wave exhibits a power-law growth with time alpha(t)beta, where beta = (gamma - 3)/(gamma - 1). This is the only example of a hydrodynamic instability whose law of growth, dependent on the equation of state, is expressed in a closed analytical form. The growth is shown to be driven by a physical mechanism similar to that of a classical Richtmyer-Meshkov instability. In the opposite extreme gamma - 1 < 1, delta(m) exhibits oscillatory growth, approximately linear with time, until it reaches its peak value approximately (gamma - 1)(-1/2), and then starts to decrease. The mechanism driving the growth is the same as that of Vishniac's instability of a blast wave in a gas with low . Exact analytical expressions for the growth rates are derived for both cases and favorably compared to hydrodynamic simulation results.

  10. High current density sheet-like electron beam generator

    NASA Astrophysics Data System (ADS)

    Chow-Miller, Cora; Korevaar, Eric; Schuster, John

    Sheet electron beams are very desirable for coupling to the evanescent waves in small millimeter wave slow-wave circuits to achieve higher powers. In particular, they are critical for operation of the free-electron-laser-like Orotron. The program was a systematic effort to establish a solid technology base for such a sheet-like electron emitter system that will facilitate the detailed studies of beam propagation stability. Specifically, the effort involved the design and test of a novel electron gun using Lanthanum hexaboride (LaB6) as the thermionic cathode material. Three sets of experiments were performed to measure beam propagation as a function of collector current, beam voltage, and heating power. The design demonstrated its reliability by delivering 386.5 hours of operation throughout the weeks of experimentation. In addition, the cathode survived two venting and pump down cycles without being poisoned or losing its emission characteristics. A current density of 10.7 A/sq cm. was measured while operating at 50 W of ohmic heating power. Preliminary results indicate that the nearby presence of a metal plate can stabilize the beam.

  11. Topologically protected unidirectional edge spin waves

    NASA Astrophysics Data System (ADS)

    Wang, Xiang Rong; Wang, Xiansi; Su, Ying

    Magnetic materials are highly correlated spin systems that do not respect the time-reversal symmetry. The low-energy excitations of magnetic materials are spin waves whose quanta are magnons. Like electronic materials that can be topologically nontrivial, a magnetic material can also be topologically nontrivial with topologically protected unidirectional edge states. These edge states should be superb channels of processing and manipulating spin waves because they are robust against perturbations and geometry changes, unlike the normal spin wave states that are very sensitive to the system changes and geometry. Therefore, the magnetic topological matter is of fundamental interest and technologically useful in magnonics. Here, we show that ferromagnetically interacting spins on a two-dimensional honeycomb lattice with nearest-neighbour interactions and governed by the Landau-Lifshitz-Gilbert equation, can be topologically nontrivial with gapped bulk spin waves and gapless edge spin waves. These edge spin waves are indeed very robust against defects under topological protection. Because of the unidirectional nature of these topologically protected edge spin waves, an interesting functional magnonic device called beam splitter can be made out of a domain wall in a strip. It is shown that an in-coming spin wave beam along one edge splits into two spin wave beams propagating along two opposite directions on the other edge after passing through a domain wall. This work was supported by Hong Kong GRF Grants (Nos. 163011151 and 16301816) and the Grant from NNSF of China (No. 11374249). X.S.W acknowledge support from UESTC.

  12. Whistler mode waves in the Jovian magnetosheath

    NASA Technical Reports Server (NTRS)

    Lin, Naiguo; Kellogg, P. J.; Thiessen, J. P.; Lengyel-Frey, D.; Tsurutani, B. T.; Phillips, J. L.

    1994-01-01

    During the Ulysses flyby of Jupiter in February 1992, the spacecraft traversed the Jovian magnetosheath for a few hours during the inbound pass and for aa few days during the outbound pass. Burstlike electomagnetic waves at frequencies of approximately 0.1-0.4 of the local electron cyclotron frequency have been observed by the Unified Radio and Plasma Wave (URAP) experiement. The waves were more often observed in the regions which were probably the outer or the middle magnetosheath, especially near the bow shock, and rarely seen in the magnetosphere/magnetosheath boundary layer. The propagation angles of the waves are estimated by comparing the measurements of the wave electric and magnetic fields in the spacecraft spin plane with the corresponding values calculated using the cold plasma dispersion relation under local field and plasma conditions. It is found that the waves propagate obliquely with wave angles between approximately 30 deg and 50 deg. These waves are likely to be the whistler mode waves which are excited by suprathermal electrons with a few hundred eV and a slight anisotropy (T(sub perp)/T(sub parallel) approximately 1.1-1.5). They are probably similar in nature to the lion roars observed in the Earth's magnetosheath. Signature of coupling between the mirror and the whistler mode have also been observed. The plasma conditions which favor the excitation of the whistler mode instability during the wave events exists as observed by the plasma experiement of Ulysses.

  13. Feels Like the Third Wave: The Rise of Fundraising in the Community College

    ERIC Educational Resources Information Center

    Milliron, Mark David; de los Santos, Gerardo E.; Browning, Boo

    2003-01-01

    Not so long ago, the word "fundraising" scarcely made an appearance in the community college lexicon. Now, as our society moves from the industrial age to the information age, it can be considered part of a wave of change flooding across the community college movement, with clear implications for how community colleges teach, reach, and lead. In…

  14. Seismic tomography of northeastern Tibetan Plateau from body wave arrival times and surface wave dispersion data

    NASA Astrophysics Data System (ADS)

    Fang, H.; Yao, H.; Zhang, H.

    2017-12-01

    Reliable crustal and upper mantle structure is important to understand expansion of material from the Tibetan plateau to its northeastern margin. Previous studies have used either ambient noise tomography or body wave traveltime tomography to obtain the crustal velocity models in northeastern Tibetan Plateau. However, clear differences appear in these models obtained using different datasets. Here we propose to jointly invert local and teleseismic body wave arrival times and surface wave dispersion data from ambient noise cross correlation to obtain a unified P and S wavespeed model of the crust and upper mantle in NE Tibetan Plateau. Following Fang et al. (2016), we adopt the direct inversion strategy for surface wave data (Fang et al., 2015), which eliminates the need to construct the phase/group velocity maps and allows the straightforward incorporation of surface wave dispersion data into the body wave inversion framework. For body wave data including both local and teleseismic arrival times, we use the fast marching method (Rawlinson et al., 2004) in order to trace multiple seismic phases simultaneously. The joint inversion method takes advantage of the complementary strengths of different data types, with local body wave data constraining more on the P than S wavespeed in the crust, surface wave data most sensitive to S wavespeed in the crust and upper mantle, teleseismic body wave data resolving the upper mantle structure. A series of synthetic tests will be used to show the robustness and superiority of the joint inversion method. Besides, the inverted model will be validated by waveform simulation and comparison with other studies, like receiver function imaging. The resultant P and S wavespeed models, as well as the derived Vp/Vs model, will be essential to understand the regional tectonics of the northeastern Tibetan Plateau, and to address the related geodynamic questions of the Tibetan Plateau formation and expansion.

  15. Thermal responses in a coronal loop maintained by wave heating mechanisms

    NASA Astrophysics Data System (ADS)

    Matsumoto, Takuma

    2018-05-01

    A full 3-dimensional compressible magnetohydrodynamic (MHD) simulation is conducted to investigate the thermal responses of a coronal loop to the dynamic dissipation processes of MHD waves. When the foot points of the loop are randomly and continuously forced, the MHD waves become excited and propagate upward. Then, 1-MK temperature corona is produced naturally as the wave energy dissipates. The excited wave packets become non-linear just above the magnetic canopy, and the wave energy cascades into smaller spatial scales. Moreover, collisions between counter-propagating Alfvén wave packets increase the heating rate, resulting in impulsive temperature increases. Our model demonstrates that the heating events in the wave-heated loops can be nanoflare-like in the sense that they are spatially localized and temporally intermittent.

  16. Coupling of WRF meteorological model to WAM spectral wave model through sea surface roughness at the Balearic Sea: impact on wind and wave forecasts

    NASA Astrophysics Data System (ADS)

    Tolosana-Delgado, R.; Soret, A.; Jorba, O.; Baldasano, J. M.; Sánchez-Arcilla, A.

    2012-04-01

    Meteorological models, like WRF, usually describe the earth surface characteristics by tables that are function of land-use. The roughness length (z0) is an example of such approach. However, over sea z0 is modeled by the Charnock (1955) relation, linking the surface friction velocity u*2 with the roughness length z0 of turbulent air flow, z0 = α-u2* g The Charnock coefficient α may be considered a measure of roughness. For the sea surface, WRF considers a constant roughness α = 0.0185. However, there is evidence that sea surface roughness should depend on wave energy (Donelan, 1982). Spectral wave models like WAM, model the evolution and propagation of wave energy as a function of wind, and include a richer sea surface roughness description. Coupling WRF and WAM is thus a common way to improve the sea surface roughness description of WRF. WAM is a third generation wave model, solving the equation of advection of wave energy subject to input/output terms of: wind growth, energy dissipation and resonant non-linear wave-wave interactions. Third generation models work on the spectral domain. WAM considers the Charnock coefficient α a complex yet known function of the total wind input term, which depends on the wind velocity and on the Charnock coefficient again. This is solved iteratively (Janssen et al., 1990). Coupling of meteorological and wave models through a common Charnock coefficient is operationally done in medium-range met forecasting systems (e.g., at ECMWF) though the impact of coupling for smaller domains is not yet clearly assessed (Warner et al, 2010). It is unclear to which extent the additional effort of coupling improves the local wind and wave fields, in comparison to the effects of other factors, like e.g. a better bathymetry and relief resolution, or a better circulation information which might have its influence on local-scale meteorological processes (local wind jets, local convection, daily marine wind regimes, etc.). This work, within the

  17. Higher-order rational solitons and rogue-like wave solutions of the (2 + 1)-dimensional nonlinear fluid mechanics equations

    NASA Astrophysics Data System (ADS)

    Wen, Xiao-Yong; Yan, Zhenya

    2017-02-01

    The novel generalized perturbation (n, M)-fold Darboux transformations (DTs) are reported for the (2 + 1)-dimensional Kadomtsev-Petviashvili (KP) equation and its extension by using the Taylor expansion of the Darboux matrix. The generalized perturbation (1 , N - 1) -fold DTs are used to find their higher-order rational solitons and rogue wave solutions in terms of determinants. The dynamics behaviors of these rogue waves are discussed in detail for different parameters and time, which display the interesting RW and soliton structures including the triangle, pentagon, heptagon profiles, etc. Moreover, we find that a new phenomenon that the parameter (a) can control the wave structures of the KP equation from the higher-order rogue waves (a ≠ 0) into higher-order rational solitons (a = 0) in (x, t)-space with y = const . These results may predict the corresponding dynamical phenomena in the models of fluid mechanics and other physically relevant systems.

  18. Longitudinal Waves Organize and Control Plants and Other Life

    NASA Astrophysics Data System (ADS)

    Wagner, Orvin E.

    2002-04-01

    Since the discovery of longitudinal waves in plants (W-waves) in 1988 I have taken data related to influences of these waves. These data include spacings between structures on plants, sap flow data, electrical data from probes traceable to effects produced by these waves, data related to the influences of gravity, data related to these waves traveling between plants and on and on. All of the data suggest that these waves provide a basis for a unified theory for plant growth and development. They likely provide a basis for growth and development for all life. The wave influences are present on the microscopic level in live plants but may not show in the microscopic pieces of material often scrutinized by the usual researcher. It is this author's conclusion that the waves mentioned are important in all life and provide what we call life which has been so difficult to pinpoint in previous work. The waves show in dead material but generally are of a much smaller amplitude than in resonating live material. In the wave theory one might compare something alive to a properly operating laser. See the

  19. Synchronous Half-Wave Rectifier

    NASA Technical Reports Server (NTRS)

    Rippel, Wally E.

    1989-01-01

    Synchronous rectifying circuit behaves like diode having unusually low voltage drop during forward-voltage half cycles. Circuit particularly useful in power supplies with potentials of 5 Vdc or less, where normal forward-voltage drops in ordinary diodes unacceptably large. Fabricated as monolithic assembly or as hybrid. Synchronous half-wave rectifier includes active circuits to attain low forward voltage drop and high rectification efficiency.

  20. Topological Anisotropy of Stone-Wales Waves in Graphenic Fragments

    PubMed Central

    Ori, Ottorino; Cataldo, Franco; Putz, Mihai V.

    2011-01-01

    Stone-Wales operators interchange four adjacent hexagons with two pentagon-heptagon 5|7 pairs that, graphically, may be iteratively propagated in the graphene layer, originating a new interesting structural defect called here Stone-Wales wave. By minimization, the Wiener index topological invariant evidences a marked anisotropy of the Stone-Wales defects that, topologically, are in fact preferably generated and propagated along the diagonal of the graphenic fragments, including carbon nanotubes and graphene nanoribbons. This peculiar edge-effect is shown in this paper having a predominant topological origin, leaving to future experimental investigations the task of verifying the occurrence in nature of wave-like defects similar to the ones proposed here. Graph-theoretical tools used in this paper for the generation and the propagation of the Stone-Wales defects waves are applicable to investigate isomeric modifications of chemical structures with various dimensionality like fullerenes, nanotubes, graphenic layers, schwarzites, zeolites. PMID:22174641