Imaging lithosphere structures using long period surface waves from ambient noise: a case study in western USA

NASA Astrophysics Data System (ADS)

Yang, Y.

2013-12-01

Since the emerging of ambient noise tomography in 2005, it has become a well-established method and been applied all over the world to imaging crustal and uppermost mantle structures because of its exclusive capability to extract short period surface waves. Most studies of ambient noise tomography performed so far use surface waves at periods shorter than 40/50 sec. There are a few studies of long period surface wave tomography from ambient noise (longer than 50 sec) in continental and global scales. To our knowledge, almost no tomography studies have been performed using long period surface waves (~50-200 sec) from ambient noise in regional scales with an aperture of several hundred kilometres. In this study, we demonstrate the capability of using long period surface waves from ambient noise in regional surface wave tomography by showing a case study of western USA using the USArray Transportable component (TA). We select about 150 TA stations located in a region including northern California, northern Nevada and Oregon as the 'base' stations and about 200 stations from Global Seismographic Network (GSN) and The International Federation of Digital Seismograph Networks (FDSN) as the 'remote' stations. We perform monthly cross-correlations of continuous ambient noise data recorded in 2006-2008 between the 'base' stations and the 'remote' stations and then use a stacking method based on instantaneous phase coherence to stack the monthly cross-correlations to obtain the final cross-correlations. The results show that high signal-to-noise ratio long period Raleigh waves are obtained between the 'base' stations and 'remote' stations located several thousand or even more than ten thousand kilometres away from the 'base' stations. By treating each of the 'remote' station as a 'virtual' teleseismic earthquake and measuring surface wave phases at the 'base' stations, we generate phase velocity maps at 50-200 sec periods in the regions covered by the 'base' stations using an array-based two-plane-wave tomography method. To evaluate the reliability of the resulting phase velocity maps, we compare them with published phase velocity maps using the same tomography method but based on teleseismic data. The comparison shows that long period surface wave phase velocity maps based 'virtual' events from ambient noise and those based on natural earthquakes are very similar with differences within the range of uncertainties. The similarity of phase velocity maps justifies the application of long period surface waves from ambient noise in regional lithosphere imaging. The successful extraction of long period surface waves between station pairs with distances as long as several thousand or ten thousand kilometres can link seismic arrays located in different continents, such as CEArray in China and USArray in USA. With the rapid developments of large scale seismic arrays in different continents, those inter-continental surface waves from ambient noise can be incorporated in both regional- and global-scale surface wave tomography to significantly increase the path coverage in both lateral and azimuthal senses, which is essential to improving imaging of high resolution heterogeneities and azimuthal anisotropy, especially at regions with gaps of azimuthal distributions of earthquakes.

Relationship between the Self-Rating Anxiety Scale score and the success rate of 64-slice computed tomography coronary angiography.

PubMed

Li, Hui; Jin, Dan; Qiao, Fang; Chen, Jianchang; Gong, Jianping

Computed tomography coronary angiography, a key method for obtaining coronary artery images, is widely used to screen for coronary artery diseases due to its noninvasive nature. In China, 64-slice computed tomography systems are now the most common models. As factors that directly affect computed tomography performance, heart rate and rhythm control are regulated by the autonomic nervous system and are highly related to the emotional state of the patient. The aim of this prospective study is to use a pre-computed tomography scan Self-Rating Anxiety Scale assessment to analyze the effects of tension and anxiety on computed tomography coronary angiography success. Subjects aged 18-85 years who were planned to undergo computed tomography coronary angiography were enrolled; 1 to 2 h before the computed tomography scan, basic patient data (gender, age, heart rate at rest, and family history) and Self-Rating Anxiety Scale score were obtained. The same group of imaging department doctors, technicians, and nurses performed computed tomography coronary angiography for all the enrolled subjects and observed whether those subjects could finish the computed tomography coronary angiography scan and provide clear, diagnostically valuable images. Participants were divided into successful (obtained diagnostically useful coronary images) and unsuccessful groups. Basic data and Self-Rating Anxiety Scale scores were compared between the groups. The Self-Rating Anxiety Scale standard score of the successful group was lower than that of the unsuccessful group (P = 0.001). As the Self-Rating Anxiety Scale standard score rose, the success rate of computed tomography coronary angiography decreased. The Self-Rating Anxiety Scale score has a negative relationship with computed tomography coronary angiography success. Anxiety can be a disadvantage in computed tomography coronary angiography examination. The pre-computed tomography coronary angiography scan Self-Rating Anxiety Scale score may be a useful tool for assessing whether a computed tomography coronary angiography scan will be successful or not. © The Author(s) 2015.

Travel-time tomography in shallow water: experimental demonstration at an ultrasonic scale.

PubMed

Roux, Philippe; Iturbe, Ion; Nicolas, Barbara; Virieux, Jean; Mars, Jérôme I

2011-09-01

Acoustic tomography in a shallow ultrasonic waveguide is demonstrated at the laboratory scale between two source-receiver arrays. At a 1/1,000 scale, the waveguide represents a 1.1-km-long, 52-m-deep ocean acoustic channel in the kilohertz frequency range. Two coplanar arrays record the transfer matrix in the time domain of the waveguide between each pair of source-receiver transducers. A time-domain, double-beamforming algorithm is simultaneously performed on the source and receiver arrays that projects the multi-reflected acoustic echoes into an equivalent set of eigenrays, which are characterized by their travel times and their launch and arrival angles. Travel-time differences are measured for each eigenray every 0.1 s when a thermal plume is generated at a given location in the waveguide. Travel-time tomography inversion is then performed using two forward models based either on ray theory or on the diffraction-based sensitivity kernel. The spatially resolved range and depth inversion data confirm the feasibility of acoustic tomography in shallow water. Comparisons are made between inversion results at 1 and 3 MHz with the inversion procedure using ray theory or the finite-frequency approach. The influence of surface fluctuations at the air-water interface is shown and discussed in the framework of shallow-water ocean tomography. © 2011 Acoustical Society of America

3D optical coherence tomography image registration for guiding cochlear implant insertion

NASA Astrophysics Data System (ADS)

Cheon, Gyeong-Woo; Jeong, Hyun-Woo; Chalasani, Preetham; Chien, Wade W.; Iordachita, Iulian; Taylor, Russell; Niparko, John; Kang, Jin U.

2014-03-01

In cochlear implant surgery, an electrode array is inserted into the cochlear canal to restore hearing to a person who is profoundly deaf or significantly hearing impaired. One critical part of the procedure is the insertion of the electrode array, which looks like a thin wire, into the cochlear canal. Although X-ray or computed tomography (CT) could be used as a reference to evaluate the pathway of the whole electrode array, there is no way to depict the intra-cochlear canal and basal turn intra-operatively to help guide insertion of the electrode array. Optical coherent tomography (OCT) is a highly effective way of visualizing internal structures of cochlea. Swept source OCT (SSOCT) having center wavelength of 1.3 micron and 2D Galvonometer mirrors was used to achieve 7-mm depth 3-D imaging. Graphics processing unit (GPU), OpenGL, C++ and C# were integrated for real-time volumetric rendering simultaneously. The 3D volume images taken by the OCT system were assembled and registered which could be used to guide a cochlear implant. We performed a feasibility study using both dry and wet temporal bones and the result is presented.

Pulse-encoded ultrasound imaging of the vitreous with an annular array.

PubMed

Silverman, Ronald H; Ketterling, Jeffrey A; Mamou, Jonathan; Lloyd, Harriet O; Filoux, Erwan; Coleman, D Jackson

2012-01-01

The vitreous body is nearly transparent both optically and ultrasonically. Conventional 10- to 12-MHz diagnostic ultrasound can detect vitreous inhomogeneities at high gain settings, but has limited resolution and sensitivity, especially outside the fixed focal zone near the retina. To improve visualization of faint intravitreal fluid/gel interfaces, the authors fabricated a spherically curved 20-MHz five-element annular array ultrasound transducer, implemented a synthetic-focusing algorithm to extend the depth-of-field, and used a pulse-encoding strategy to increase sensitivity. The authors evaluated a human subject with a recent posterior vitreous detachment and compared the annular array with conventional 10-MHz ultrasound and spectral-domain optical coherence tomography. With synthetic focusing and chirp pulse-encoding, the array allowed visualization of the formed and fluid components of the vitreous with improved sensitivity and resolution compared with the conventional B-scan. Although optical coherence tomography allowed assessment of the posterior vitreoretinal interface, the ultrasound array allowed evaluation of the entire vitreous body. Copyright 2012, SLACK Incorporated.

Application of electrical resistivity tomography techniques for mapping man-made sinkholes

NASA Astrophysics Data System (ADS)

Rey, J.; Martínez, J.; Hidalgo, C.; Dueñas, J.

2012-04-01

The suitability of the geophysical prospecting by electrical resistivity tomography to detect and map man-made subsurface cavities and related sinkholes has been studied in the Linares abandoned mining district (Spain). We have selected for this study four mined sectors constituted of different lithologies: granite and phyllites of Paleozoic age, and Triassic shales and sandstones. In three of these sectors, detail underground topographic surveys were carried out to chart the position and dimensions of the mining voids (galleries and chamber), in order to analyze the resolution of this methodology to characterize these cavities by using different electrode arrays. The results are variable, depending on the depth and diameter of the void, the selected electrode array, the spacing between electrodes, geological complexity and data density. These results also indicate that when the cavity is empty, an anomaly with a steep gradient and high resistivity values is registered, because the air that fills the mining void is dielectric, while when the cavities are filled with fine grain sediments, frequently saturated in water, the electrical resistance is lower. In relation with the three different multi-electrode arrays tested, the Wenner-Schlumberger array has resulted to offer the maximum resolution in all these cases, with lower and more stable values for the RMS than the other arrays. Therefore, this electrode array has been applied in the fourth studied sector, a former mine near the city centre of Linares, in an area of urban expansion in which there are problems of subsidence. Two sets of four electrical tomography profiles have been carried out, perpendicular to each other, and which have allowed reaching depths of research between 30-35 m. This net-array allowed the identification of two shallow anomalies of low resistivity values, interpreted as old mining galleries filled with fine material saturated in water. It also allows detecting two fractures, correlated in the profiles and which can be mapped to more than 25 m in depth. As showed by this case study, electrical resistivity tomography can be a suitable tool in sub-surface cavities detection and man-made sinkhole investigations.

Near-surface high resolution imaging of a metallogenic zone in the northern fringe of Dalma volcanics in eastern India using electrical resistivity tomography

NASA Astrophysics Data System (ADS)

Adhikari, P. K.; Srivastava, Shalivahan; Maurya, Ved P.; Tripathi, Anurag; Singh, Roshan K.; Bage, Ashish K.

2017-06-01

Electrical resistivity tomography (ERT) is a useful tool to map near-surface conducting anomalies. The detailed ERT survey was taken over an already defined conducting zone on a regional scale through a magnetotelluric (MT) survey, in order to provide better resolution of the subsurface structure within the study area. The survey lines were carried out crossing the delineated conducting zone through MT giving a dense coverage over the area. The ERT survey were carried out along 15 lines covering an area of ~1 km2 with a line spacing of ~50 m in the northern fringe of the Dalma volcanics (DVs). The study utilised the 61-channel cum 64-electrode resistivity equipment, FlashRES-Universal ERT multi-electrode data acquisition system, developed by ZZ Resistivity Imaging, Australia. Data has been acquired both through conventional arrays i.e. Wenner, Schlumberger and ZZ unconventional arrays. Inversion of the data set have been performed using 2.5D finite element conjugate gradient algorithm after performing the quality check. Resistivity models along all the lines were obtained using Wenner, Schlumberger and combination of Wenner, Schlumberger and ZZ arrays. Resistivity models resolved four major zones: (1) resistivity less than 1 Ωm (2) resistivity 1-10 Ωm (3) resistivity 10-100 Ωm and (4) resistivity more than 100 Ωm . The resistivity results corroborate well with the geological succession from the drilling data. The conducting zones with resistivity values ranging from 1-10 Ωm correlates with the Lower Dalma volcanics while the Upper Dalma volcanics corresponds to the regions with resistivity values of less than 1 Ωm. The Upper Dalma volcanics corresponds to the metallogeny while the depth to the top of the ore body is ~25 m.

High-contrast X-ray micro-tomography of low attenuation samples using large area hybrid semiconductor pixel detector array of 10 × 5 Timepix chips

NASA Astrophysics Data System (ADS)

Karch, J.; Krejci, F.; Bartl, B.; Dudak, J.; Kuba, J.; Kvacek, J.; Zemlicka, J.

2016-01-01

State-of-the-art hybrid pixel semiconductor detectors provide excellent imaging properties such as unlimited dynamic range, high spatial resolution, high frame rate and energy sensitivity. Nevertheless, a limitation in the use of these devices for imaging has been the small sensitive area of a few square centimetres. In the field of microtomography we make use of a large area pixel detector assembled from 50 Timepix edgeless chips providing fully sensitive area of 14.3 × 7.15 cm2. We have successfully demonstrated that the enlargement of the sensitive area enables high-quality tomographic measurements of whole objects with high geometrical magnification without any significant degradation in resulting reconstructions related to the chip tilling and edgeless sensor technology properties. The technique of micro-tomography with the newly developed large area detector is applied for samples formed by low attenuation, low contrast materials such a seed from Phacelia tanacetifolia, a charcoalified wood sample and a beeswax seal sample.

Crust and Upper Mantle Structure Beneath Tibet and SW China From Seismic Tomography and Array Analysis

NASA Astrophysics Data System (ADS)

van der Hilst, R. D.; Li, C.; Yao, H.; Sun, R.; Meltzer, A. S.

2007-12-01

We will present a summary of the results of our seismological studies of crust and upper mantle heterogeneity and anisotropy beneath Tibet and SW China with data from temporary (PASSCAL) arrays as well as other regional, national, and global networks. In 2003 and 2004 MIT and CIGMR (Chengdu Institute of Geology and Mineral Resources) operated a 25 station array (3-component, broad band seismometers) in Sichuan and Yunnan provinces, SW China; during the same period Lehigh University (also in collaboration with CIGMR) operated a 75 station array in east Tibet. Data from these arrays allow delineation of mantle structure in unprecedented detail. We focus our presentation on results of two lines of seismological study. Travel time tomography (Li et al., PEPI, 2006; EPSL, 2007) with hand-picked phase arrivals from recordings at regional arrays, and combined with data from over 1,000 stations in China and with the global data base due to Engdahl et al. (BSSA, 1998), reveals substantial the structural complexity of the upper mantle beneath SE Asia. In particular, structures associated with subduction of the Indian plate beneath the Himalayas vary significantly from west Tibet (where the plate seems to have underthrusted the entire plateau) to east Tibet (where P-wave tomography provides no evidence for the presence of fast lithosphere beneath the Plateau proper). Further east, fast structures appear in the upper mantle transition zone, presumably related to stagnation of slab fragments associated with subduction of the Pacific plate. (2) Surface wave array tomography (Yao et al., GJI, 2006, 2007), using ambient noise interferometry and traditional (inter station) dispersion analysis, is used to delineate the 3-D structure of the crust and lithospheric mantle at length scales as small as 100 km beneath the MIT and Lehigh arrays. This analysis reveals a complex spatial distribution of intra-crustal low velocity zones (which may imply that crustal-scale faults influence the pattern of middle/lower crustal flow). We will also show preliminary results of surface wave inversion for azimuthal anisotropy, which - combined with previous results from shear wave splitting (Lev et al., EPSL, 2006) - give insight into the deformation of the upper mantle beneath the area under study.

Modified electrical survey for effective leakage detection at concrete hydraulic facilities

NASA Astrophysics Data System (ADS)

Lee, Bomi; Oh, Seokhoon

2018-02-01

Three original electrode arrays for the effective leakage detection of concrete hydraulic facilities through electrical resistivity surveys are proposed: 'cross-potential', 'direct-potential' and modified tomography-like arrays. The main differences with respect to the commonly used arrays are that the current line-sources are separated from potential pole lines and floated upon the water. The potential pole lines are located directly next to the facility in order to obtain intuitive data and useful interpretations of the internal conditions of the hydraulic facility. This modified configuration of the array clearly displays the horizontal variation of the electrical field around the damaged zones of the concrete hydraulic facility, and any anomalous regions that might be found between potential poles placed across the facilities. In order to facilitate the interpretation of these modified electrical surveys, a new and creative way of presenting the measurements is also proposed and an inversion approach is provided for the modified tomography-like array. A numerical modeling and two field tests were performed to verify these new arrays and interpretation methods. The cross and direct potential array implied an ability to detect small variations of the potential field near the measurement poles. The proposed array showed the overall potential distribution across the hydraulic facility which may be used to assist in the search of trouble zones within the structure, in combination with the traditional electrical resistivity array.

Ambient Noise Correlation Amplitudes and Local Site Response

NASA Astrophysics Data System (ADS)

Bowden, D. C.; Tsai, V. C.; Lin, F. C.

2014-12-01

We investigate amplitudes from ambient noise cross correlations in a spatially dense array. Our study of wave propagation effects and ambient noise is focused on the Long Beach Array, with more than 5000 single component geophones in an area of about 100 square kilometers, providing high resolution imaging of shallow crustal features. The method allows for observations of ground properties like site response and attenuation, which can well supplement traditional velocity models and simulations for seismic hazard. Traditional ambient noise cross correlations have proven to be an effective means of measuring velocity information about surface waves, but the amplitudes of such signals in traditional processing are often distorted. We discuss a method of signal processing which preserves relative amplitudes of signals within an array, and the subsequent processing to track wave motion across the array. Previous work showed promising correlation to known local structure, but did not represent a thorough application of tomographic methods. Now we extend the methodology to more robustly consider wavefront focusing and defocusing, interference with higher modes, and discuss the differing effects of local site response, attenuation, and scattering. Application of Helmholtz tomography and determination of local site amplification has previously been demonstrated using earthquake data on the continental scale with USArray, but the exploitation of the ambient noise field is required both for the higher frequencies needed by seismic hazard studies and for the short deployment time of a Long Beach scale array. We outline both the successes and shortcomings of the methodology, and show how it can be extended for use on future arrays.

Dual source and dual detector arrays tetrahedron beam computed tomography for image guided radiotherapy.

PubMed

Kim, Joshua; Lu, Weiguo; Zhang, Tiezhi

2014-02-07

Cone-beam computed tomography (CBCT) is an important online imaging modality for image guided radiotherapy. But suboptimal image quality and the lack of a real-time stereoscopic imaging function limit its implementation in advanced treatment techniques, such as online adaptive and 4D radiotherapy. Tetrahedron beam computed tomography (TBCT) is a novel online imaging modality designed to improve on the image quality provided by CBCT. TBCT geometry is flexible, and multiple detector and source arrays can be used for different applications. In this paper, we describe a novel dual source-dual detector TBCT system that is specially designed for LINAC radiation treatment machines. The imaging system is positioned in-line with the MV beam and is composed of two linear array x-ray sources mounted aside the electrical portal imaging device and two linear arrays of x-ray detectors mounted below the machine head. The detector and x-ray source arrays are orthogonal to each other, and each pair of source and detector arrays forms a tetrahedral volume. Four planer images can be obtained from different view angles at each gantry position at a frame rate as high as 20 frames per second. The overlapped regions provide a stereoscopic field of view of approximately 10-15 cm. With a half gantry rotation, a volumetric CT image can be reconstructed having a 45 cm field of view. Due to the scatter rejecting design of the TBCT geometry, the system can potentially produce high quality 2D and 3D images with less radiation exposure. The design of the dual source-dual detector system is described, and preliminary results of studies performed on numerical phantoms and simulated patient data are presented.

Dual source and dual detector arrays tetrahedron beam computed tomography for image guided radiotherapy

NASA Astrophysics Data System (ADS)

Kim, Joshua; Lu, Weiguo; Zhang, Tiezhi

2014-02-01

Cone-beam computed tomography (CBCT) is an important online imaging modality for image guided radiotherapy. But suboptimal image quality and the lack of a real-time stereoscopic imaging function limit its implementation in advanced treatment techniques, such as online adaptive and 4D radiotherapy. Tetrahedron beam computed tomography (TBCT) is a novel online imaging modality designed to improve on the image quality provided by CBCT. TBCT geometry is flexible, and multiple detector and source arrays can be used for different applications. In this paper, we describe a novel dual source-dual detector TBCT system that is specially designed for LINAC radiation treatment machines. The imaging system is positioned in-line with the MV beam and is composed of two linear array x-ray sources mounted aside the electrical portal imaging device and two linear arrays of x-ray detectors mounted below the machine head. The detector and x-ray source arrays are orthogonal to each other, and each pair of source and detector arrays forms a tetrahedral volume. Four planer images can be obtained from different view angles at each gantry position at a frame rate as high as 20 frames per second. The overlapped regions provide a stereoscopic field of view of approximately 10-15 cm. With a half gantry rotation, a volumetric CT image can be reconstructed having a 45 cm field of view. Due to the scatter rejecting design of the TBCT geometry, the system can potentially produce high quality 2D and 3D images with less radiation exposure. The design of the dual source-dual detector system is described, and preliminary results of studies performed on numerical phantoms and simulated patient data are presented.

Research on ambient noise tomography in Fenwei Fault array

NASA Astrophysics Data System (ADS)

Xu, H.; Luo, Y.; Yin, X.

2016-12-01

From June 2014 to May 2015, 561 Empirical Green's functions (EGFs) between two station pairs are obtained by processing continuous ambient noise observed at 34 stations from Fenwei Fault array. All available vertical component series are utilized to extract the Rayleigh waves. The signal-to-noise ratio (SNR) at different periods and the azimuth distribution of the interstation pairs with high SNR are discussed. The azimuth distributions of the ambient noise source are investigated by analyzing the beamforming output. Although seasonal variations are observed from the beamforming output, the source distribution at 10-25 S is almost uniformly distributed in all directions, which allows us to perform the following detailed tomography safely. From these EGFs, surface wave travel times in the period range of 5 to 40 S are measured by Frequency-Time Analysis technique (FTAN). Then, eikonal tomography is adopted to construct Rayleigh wave phase velocity maps and estimate the phase velocity uncertainties. Finally, we invert the obtained phase velocity dispersion curves for 1D shear velocity profiles and then assemble these 1D profiles to construct a 3D shear velocity model. Major velocity features of our 3D model are correlated well with the known geological features. In the shallow, the shear velocity of the fault is low-speed which is related to sedimentary basins, and the surrounding ridges is high-speed. References Lin, F., Ritzwoller, M.H. and Snieder, R., 2009. Eikonal tomography: surface wave tomography by phase front tracking across a regional broad-band seismic array. Geophysical Journal International, 177(3): 1091-1110.

Micromachined silicon parallel acoustic delay lines as time-delayed ultrasound detector array for real-time photoacoustic tomography

NASA Astrophysics Data System (ADS)

Cho, Y.; Chang, C.-C.; Wang, L. V.; Zou, J.

2016-02-01

This paper reports the development of a new 16-channel parallel acoustic delay line (PADL) array for real-time photoacoustic tomography (PAT). The PADLs were directly fabricated from single-crystalline silicon substrates using deep reactive ion etching. Compared with other acoustic delay lines (e.g., optical fibers), the micromachined silicon PADLs offer higher acoustic transmission efficiency, smaller form factor, easier assembly, and mass production capability. To demonstrate its real-time photoacoustic imaging capability, the silicon PADL array was interfaced with one single-element ultrasonic transducer followed by one channel of data acquisition electronics to receive 16 channels of photoacoustic signals simultaneously. A PAT image of an optically-absorbing target embedded in an optically-scattering phantom was reconstructed, which matched well with the actual size of the imaged target. Because the silicon PADL array allows a signal-to-channel reduction ratio of 16:1, it could significantly simplify the design and construction of ultrasonic receivers for real-time PAT.

Electronic resistance tomography imaging of spatial moisture distribution, moisture distribution and movement in pavements

DOT National Transportation Integrated Search

1997-07-01

Electronic resistance tomography (ERT) was used to follow the infiltration of water into a pavement section at the UC Berkeley Richmond Field Station. A volume of pavement 1 m square and 1.29 m in depth was sampled by an ERT array consisting of elect...

Using Contaminant Transport Simulations to Optimize Electrical Resistivity Tomography Survey Design for Improved Contaminant Detection at Lined Ponds

NASA Astrophysics Data System (ADS)

Herring, T.; Pidlisecky, A.

2015-12-01

The saline flowback water produced during hydraulic fracturing is often stored in lined surface ponds. Leakage from these ponds poses a significant environmental threat and there is a need for a reliable and economical long term monitoring strategy. Electrical resistivity tomography (ERT), being sensitive to changes in groundwater salinity, is therefore well suited to such a problem. The goal of this work is to compare the leak detection capabilities of a surface ERT array and a downhole ERT array. In this study several plausible 3D electrical conductivity models were created that simulated a contaminant plume evolving over time, using realistic contaminant concentrations, plume geometries, water saturation profiles, and seasonal temperature profiles. The forward modeled data were used to identify the advantages and drawbacks of using each ERT array orientation.

Positron emission tomography wrist detector

DOEpatents

Schlyer, David J.; O'Connor, Paul; Woody, Craig; Junnarkar, Sachin Shrirang; Radeka, Veljko; Vaska, Paul; Pratte, Jean-Francois

2006-08-15

A method of serially transferring annihilation information in a compact positron emission tomography (PET) scanner includes generating a time signal representing a time-of-occurrence of an annihilation event, generating an address signal representing a channel detecting the annihilation event, and generating a channel signal including the time and address signals. The method also includes generating a composite signal including the channel signal and another similarly generated channel signal concerning another annihilation event. An apparatus that serially transfers annihilation information includes a time signal generator, address signal generator, channel signal generator, and composite signal generator. The time signal is asynchronous and the address signal is synchronous to a clock signal. A PET scanner includes a scintillation array, detection array, front-end array, and a serial encoder. The serial encoders include the time signal generator, address signal generator, channel signal generator, and composite signal generator.

Spectroscopic optical coherence tomography based on wavelength de-multiplexing and smart pixel array detection

NASA Astrophysics Data System (ADS)

Laubscher, Markus; Bourquin, Stéphane; Froehly, Luc; Karamata, Boris; Lasser, Theo

2004-07-01

Current spectroscopic optical coherence tomography (OCT) methods rely on a posteriori numerical calculation. We present an experimental alternative for accessing spectroscopic information in OCT without post-processing based on wavelength de-multiplexing and parallel detection using a diffraction grating and a smart pixel detector array. Both a conventional A-scan with high axial resolution and the spectrally resolved measurement are acquired simultaneously. A proof-of-principle demonstration is given on a dynamically changing absorbing sample. The method's potential for fast spectroscopic OCT imaging is discussed. The spectral measurements obtained with this approach are insensitive to scan non-linearities or sample movements.

Single-lens computed tomography imaging spectrometer and method of capturing spatial and spectral information

NASA Technical Reports Server (NTRS)

Wilson, Daniel W. (Inventor); Johnson, William R. (Inventor); Bearman, Gregory H. (Inventor)

2011-01-01

Computed tomography imaging spectrometers ("CTISs") employing a single lens are provided. The CTISs may be either transmissive or reflective, and the single lens is either configured to transmit and receive uncollimated light (in transmissive systems), or is configured to reflect and receive uncollimated light (in reflective systems). An exemplary transmissive CTIS includes a focal plane array detector, a single lens configured to transmit and receive uncollimated light, a two-dimensional grating, and a field stop aperture. An exemplary reflective CTIS includes a focal plane array detector, a single mirror configured to reflect and receive uncollimated light, a two-dimensional grating, and a field stop aperture.

Constraints on a plume in the mid-mantle beneath the Iceland region from seismic array data

USGS Publications Warehouse

Pritchard, M.J.; Foulger, G.R.; Julian, B.R.; Fyen, J.

2000-01-01

Teleseismic P waves passing through low-wave-speed bodies in the mantle are refracted, causing anomalies in their propagation directions that can be measured by seismometer arrays. Waves from earthquakes in the eastern Pacific and western North America arriving at the NORSAR array in Norway and at seismic stations in Scotland pass beneath the Iceland region at depths of ~ 1000-2000 km. Waves arriving at NORSAR have anomalous arrival azimuths consistent with a low-wave-speed body at a depth of ~ 1500 km beneath the Iceland-Faeroe ridge with a maximum diameter of ~ 250 km and a maximum wave-speed contrast of ~ 1.5 per cent. This agrees well with whole-mantle tomography results, which image a low-wave-speed body at this location with a diameter of ~ 500 km and a wave-speed anomaly of ~ 0.5 per cent, bearing in mind that whole-mantle tomography, because of its limited resolution, broadens and weakens small anomalies. The observations cannot resolve the location of the body, and the anomaly could be caused in whole or in part by larger bodies farther away, for example by a body imaged beneath Greenland by whole-mantle tomography.

Method of lungs regional ventilation function assessment on the basis of continuous lung monitoring results using multi-angle electrical impedance tomography

NASA Astrophysics Data System (ADS)

Aleksanyan, Grayr; Shcherbakov, Ivan; Kucher, Artem; Sulyz, Andrew

2018-04-01

With continuous monitoring of the lungs using multi-angle electric impedance tomography method, a large array of images of impedance changes in the patient's chest cavity is accumulated. This article proposes a method for evaluating the regional ventilation function of lungs based on the results of continuous monitoring using the multi-angle electric impedance tomography method, which allows one image of the thoracic cavity to be formed on the basis of a large array of images of the impedance change in the patient's chest cavity. In the presence of pathologies in the lungs (neoplasms, fluid, pneumothorax, etc.) in these areas, air filling will be disrupted, which will be displayed on the generated image. When conducting continuous monitoring in several sections, a three-dimensional pattern of air filling of the thoracic cavity is possible.

10-channel fiber array fabrication technique for parallel optical coherence tomography system

NASA Astrophysics Data System (ADS)

Arauz, Lina J.; Luo, Yuan; Castillo, Jose E.; Kostuk, Raymond K.; Barton, Jennifer

2007-02-01

Optical Coherence Tomography (OCT) shows great promise for low intrusive biomedical imaging applications. A parallel OCT system is a novel technique that replaces mechanical transverse scanning with electronic scanning. This will reduce the time required to acquire image data. In this system an array of small diameter fibers is required to obtain an image in the transverse direction. Each fiber in the array is configured in an interferometer and is used to image one pixel in the transverse direction. In this paper we describe a technique to package 15μm diameter fibers on a siliconsilica substrate to be used in a 2mm endoscopic probe tip. Single mode fibers are etched to reduce the cladding diameter from 125μm to 15μm. Etched fibers are placed into a 4mm by 150μm trench in a silicon-silica substrate and secured with UV glue. Active alignment was used to simplify the lay out of the fibers and minimize unwanted horizontal displacement of the fibers. A 10-channel fiber array was built, tested and later incorporated into a parallel optical coherence system. This paper describes the packaging, testing, and operation of the array in a parallel OCT system.

Ambient Noise Interferometry and Surface Wave Array Tomography: Promises and Problems

NASA Astrophysics Data System (ADS)

van der Hilst, R. D.; Yao, H.; de Hoop, M. V.; Campman, X.; Solna, K.

2008-12-01

In the late 1990ies most seismologists would have frowned at the possibility of doing high-resolution surface wave tomography with noise instead of with signal associated with ballistic source-receiver propagation. Some may still do, but surface wave tomography with Green's functions estimated through ambient noise interferometry ('sourceless tomography') has transformed from a curiosity into one of the (almost) standard tools for analysis of data from dense seismograph arrays. Indeed, spectacular applications of ambient noise surface wave tomography have recently been published. For example, application to data from arrays in SE Tibet revealed structures in the crust beneath the Tibetan plateau that could not be resolved by traditional tomography (Yao et al., GJI, 2006, 2008). While the approach is conceptually simple, in application the proverbial devil is in the detail. Full reconstruction of the Green's function requires that the wavefields used are diffusive and that ambient noise energy is evenly distributed in the spatial dimensions of interest. In the field, these conditions are not usually met, and (frequency dependent) non-uniformity of the noise sources may lead to incomplete reconstruction of the Green's function. Furthermore, ambient noise distributions can be time-dependent, and seasonal variations have been documented. Naive use of empirical Green's functions may produce (unknown) bias in the tomographic models. The degrading effect on EGFs of the directionality of noise distribution forms particular challenges for applications beyond isotropic surface wave inversions, such as inversions for (azimuthal) anisotropy and attempts to use higher modes (or body waves). Incomplete Green's function reconstruction can (probably) not be prevented, but it may be possible to reduce the problem and - at least - understand the degree of incomplete reconstruction and prevent it from degrading the tomographic model. We will present examples of Rayleigh wave inversions and discuss strategies to mitigate effects of incomplete Green's function reconstruction on tomographic images.

Evaluation of the hybrid-L24 electrode using microcomputed tomography.

PubMed

Driscoll, Colin L W; Carlson, Matthew L; Fama, Anthony F; Lane, John I

2011-07-01

To compare electrode array position, and depth of insertion of the Cochlear Hybrid-L24 electrode array following traditional cochleostomy and round window (RW) insertion. Prospective cadaveric temporal bone study. Ten cadaveric temporal bones were implanted with the Hybrid-L24 electrode array; half were introduced through a RW approach, whereas the other half were inserted through a traditional scala tympani cochleostomy. A micro-CT scanner was then used to evaluate electrode position, intracochlear trauma, and depth of insertion. All electrodes were inserted into the scala tympani without significant resistance. No electrodes demonstrated tip fold-over or through-fracturing of the osseous spiral lamina, basilar membrane, or spiral ligament. The average angular depth of insertion for all 10 electrodes was 252.4°. Compared to cochleostomy insertions, electrodes inserted through the RW more commonly acquired a proximal perimodiolar orientation, followed a more predictable course, and less commonly contacted critical soft tissue structures. The results of this study demonstrate that the Hybrid-L24 electrode can be successfully inserted using a RW or traditional cochleostomy technique with minimal intracochlear trauma. Our data also suggests that with this model, RW insertions may provide particular advantages with respect to hearing preservation over the traditional cochleostomy approach. Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

Quarterly Research Performance Progress Report (2015 Q3). Ultrasonic Phased Arrays and Interactive Reflectivity Tomography for Nondestructive Inspection of Injection and Production Wells in Geothermal Energy Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Santos-Villalobos, Hector J; Polsky, Yarom; Kisner, Roger A

2015-09-01

For the past quarter, we have placed our effort in implementing the first version of the ModelBased Iterative Reconstruction (MBIR) algorithm, assembling and testing the electronics, designing transducers mounts, and defining our laboratory test samples. We have successfully developed the first implementation of MBIR for ultrasound imaging. The current algorithm was tested with synthetic data and we are currently making new modifications for the reconstruction of real ultrasound data. Beside assembling and testing the electronics, we developed a LabView graphic user interface (GUI) to fully control the ultrasonic phased array, adjust the time-delays of the transducers, and store the measuredmore » reflections. As part of preparing for a laboratory-scale demonstration, the design and fabrication of the laboratory samples has begun. Three cement blocks with embedded objects will be fabricated, characterized, and used to demonstrate the capabilities of the system. During the next quarter, we will continue to improve the current MBIR forward model and integrate the reconstruction code with the LabView GUI. In addition, we will define focal laws for the ultrasonic phased array and perform the laboratory demonstration. We expect to perform laboratory demonstration by the end of October 2015.« less

Broadband Terahertz Computed Tomography Using a 5k-pixel Real-time THz Camera

NASA Astrophysics Data System (ADS)

Trichopoulos, Georgios C.; Sertel, Kubilay

2015-07-01

We present a novel THz computed tomography system that enables fast 3-dimensional imaging and spectroscopy in the 0.6-1.2 THz band. The system is based on a new real-time broadband THz camera that enables rapid acquisition of multiple cross-sectional images required in computed tomography. Tomographic reconstruction is achieved using digital images from the densely-packed large-format (80×64) focal plane array sensor located behind a hyper-hemispherical silicon lens. Each pixel of the sensor array consists of an 85 μm × 92 μm lithographically fabricated wideband dual-slot antenna, monolithically integrated with an ultra-fast diode tuned to operate in the 0.6-1.2 THz regime. Concurrently, optimum impedance matching was implemented for maximum pixel sensitivity, enabling 5 frames-per-second image acquisition speed. As such, the THz computed tomography system generates diffraction-limited resolution cross-section images as well as the three-dimensional models of various opaque and partially transparent objects. As an example, an over-the-counter vitamin supplement pill is imaged and its material composition is reconstructed. The new THz camera enables, for the first time, a practical application of THz computed tomography for non-destructive evaluation and biomedical imaging.

Improvement of resolution in full-view linear-array photoacoustic computed tomography using a novel adaptive weighting method

NASA Astrophysics Data System (ADS)

Omidi, Parsa; Diop, Mamadou; Carson, Jeffrey; Nasiriavanaki, Mohammadreza

2017-03-01

Linear-array-based photoacoustic computed tomography is a popular methodology for deep and high resolution imaging. However, issues such as phase aberration, side-lobe effects, and propagation limitations deteriorate the resolution. The effect of phase aberration due to acoustic attenuation and constant assumption of the speed of sound (SoS) can be reduced by applying an adaptive weighting method such as the coherence factor (CF). Utilizing an adaptive beamforming algorithm such as the minimum variance (MV) can improve the resolution at the focal point by eliminating the side-lobes. Moreover, invisibility of directional objects emitting parallel to the detection plane, such as vessels and other absorbing structures stretched in the direction perpendicular to the detection plane can degrade resolution. In this study, we propose a full-view array level weighting algorithm in which different weighs are assigned to different positions of the linear array based on an orientation algorithm which uses the histogram of oriented gradient (HOG). Simulation results obtained from a synthetic phantom show the superior performance of the proposed method over the existing reconstruction methods.

Extremely high resolution 3D electrical resistivity tomography to depict archaeological subsurface structures

NASA Astrophysics Data System (ADS)

Al-Saadi, Osamah; Schmidt, Volkmar; Becken, Michael; Fritsch, Thomas

2017-04-01

Electrical resistivity tomography (ERT) methods have been increasingly used in various shallow depth archaeological prospections in the last few decades. These non-invasive techniques are very useful in saving time, costs, and efforts. Both 2D and 3D ERT techniques are used to obtain detailed images of subsurface anomalies. In two surveyed areas near Nonnweiler (Germany), we present the results of the full 3D setup with a roll-along technique and of the quasi-3D setup (parallel and orthogonal profiles in dipole-dipole configuration). In area A, a dipole-dipole array with 96 electrodes in a uniform rectangular survey grid has been used in full 3D to investigate a presumed Roman building. A roll-along technique has been utilized to cover a large part of the archaeological site with an electrode spacing of 1 meter and with 0.5 meter for a more detailed image. Additional dense parallel 2D profiles have been carried out in dipole-dipole array with 0.25 meter electrode spacing and 0.25 meter between adjacent profiles in both direction for higher- resolution subsurface images. We have designed a new field procedure, which used an electrode array fixed in a frame. This facilitates efficient field operation, which comprised 2376 electrode positions. With the quasi 3D imaging, we confirmed the full 3D inversion model but at a much better resolution. In area B, dense parallel 2D profiles were directly used to survey the second target with also 0.25 meter electrode spacing and profiles separation respectively. The same field measurement design has been utilized and comprised 9648 electrode positions in total. The quasi-3D inversion results clearly revealed the main structures of the Roman construction. These ERT inversion results coincided well with the archaeological excavation, which has been done in some parts of this area. The ERT result successfully images parts from the walls and also smaller internal structures of the Roman building.

Detection of foreign body using fast thermoacoustic tomography with a multielement linear transducer array

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nie Liming; Xing Da; Yang Diwu

2007-04-23

Current imaging modalities face challenges in clinical applications due to limitations in resolution or contrast. Microwave-induced thermoacoustic imaging may provide a complementary modality for medical imaging, particularly for detecting foreign objects due to their different absorption of electromagnetic radiation at specific frequencies. A thermoacoustic tomography system with a multielement linear transducer array was developed and used to detect foreign objects in tissue. Radiography and thermoacoustic images of objects with different electromagnetic properties, including glass, sand, and iron, were compared. The authors' results demonstrate that thermoacoustic imaging has the potential to become a fast method for surgical localization of occult foreignmore » objects.« less

Ultrasound-guided chest biopsies.

PubMed

Middleton, William D; Teefey, Sharlene A; Dahiya, Nirvikar

2006-12-01

Pulmonary nodules that are surrounded by aerated lung cannot be visualized with sonography. Therefore, percutaneous biopsy must be guided with computed tomography or fluoroscopy. Although this restriction only applies to central lung nodules, it has permeated referral patterns for other thoracic lesions and has retarded the growth of ultrasound-guided interventions. Nevertheless, sonography is an extremely flexible modality that can expeditiously guide many biopsy procedures in the thorax. Peripheral pulmonary nodules can be successfully biopsied with success rates exceeding 90% and complications rates of less than 5%. Orienting the probe parallel to the intercostal space facilitates biopsies of peripheral pulmonary nodules. Anterior mediastinal masses that extend to the parasternal region are often easily approachable provided the internal mammary vessels, costal cartilage, and deep great vessels are identified and avoided. Superior mediastinal masses can be sampled from a suprasternal or supraclavicular approach. Phased array probes or tightly curved arrays may provide improved access for biopsies in this location. Posterior mediastinal masses are more difficult to biopsy with ultrasound guidance because of the overlying paraspinal muscles. However, when posterior mediastinal masses extend into the posterior medial pleural region, they can be biopsied with ultrasound guidance. Because many lung cancers metastasize to the supraclavicular nodes, it is important to evaluate the supraclavicular region when determining the best approach to obtain a tissue diagnosis. When abnormal supraclavicular nodes are present, they often are the easiest and safest lesions to biopsy.

A Submillimeter Resolution PET Prototype Evaluated With an 18F Inkjet Printed Phantom

NASA Astrophysics Data System (ADS)

Schneider, Florian R.; Hohberg, Melanie; Mann, Alexander B.; Paul, Stephan; Ziegler, Sibylle I.

2015-10-01

This work presents a submillimeter resolution PET (Positron Emission Tomography) scanner prototype based on SiPM/MPPC arrays (Silicon Photomultiplier/Multi Pixel Photon Counter). Onto each active area a 1 ×1 ×20 mm3 LYSO (Lutetium-Yttrium-Oxyorthosilicate) scintillator crystal is coupled one-to-one. Two detector modules facing each other in a distance of 10.0 cm have been set up with in total 64 channels that are digitized by SADCs (Sampling Analog to Digital Converters) with 80 MHz, 10 bit resolution and FPGA (Field Programmable Gate Array) based extraction of energy and time information. Since standard phantoms are not sufficient for testing submillimeter resolution at which positron range is an issue, a 18F inkjet printed phantom has been used to explore the limit in spatial resolution. The phantom could be successfully reconstructed with an iterative MLEM (Maximum Likelihood Expectation Maximization) and an analytically calculated system matrix based on the DRF (Detector Response Function) model. The system yields a coincidence time resolution of 4.8 ns FWHM, an energy resolution of 20%-30% FWHM and a spatial resolution of 0.8 mm.

Limited angle breast ultrasound tomography with a priori information and artifact removal

NASA Astrophysics Data System (ADS)

Jintamethasawat, Rungroj; Zhu, Yunhao; Kripfgans, Oliver D.; Yuan, Jie; Goodsitt, Mitchell M.; Carson, Paul L.

2017-03-01

In B-mode images from dual-sided ultrasound, it has been shown that by delineating structures suspected of being relatively homogeneous, one can enhance limited angle tomography to produce speed of sound images in the same view as X-ray Digital Breast Tomography (DBT). This could allow better breast cancer detection and discrimination, as well as improved registration of the ultrasound and X-ray images, because of the similarity of SOS and X-ray contrast in the breast. However, this speed of sound reconstruction method relies strongly on B-mode or other reflection mode segmentation. If that information is limited or incorrect, artifacts will appear in the reconstructed images. Therefore, the iterative speed of sound reconstruction algorithm has been modified in a manner of simultaneously utilizing the image segmentations and removing most artifacts. The first step of incorporating a priori information is solved by any nonlinearnonconvex optimization method while artifact removal is accomplished by employing the fast split Bregman method to perform total-variation (TV) regularization for image denoising. The proposed method was demonstrated in simplified simulations of our dual-sided ultrasound scanner. To speed these computations two opposed 40-element ultrasound linear arrays with 0.5 MHz center frequency were simulated for imaging objects in a uniform background. The proposed speed of sound reconstruction method worked well with both bent-ray and full-wave inversion methods. This is also the first demonstration of successful full-wave medical ultrasound tomography in the limited angle geometry. Presented results lend credibility to a possible translation of this method to clinical breast imaging.

Experimental Validation of a Fast Forward Model for Guided Wave Tomography of Pipe Elbows.

PubMed

Brath, Alex J; Simonetti, Francesco; Nagy, Peter B; Instanes, Geir

2017-05-01

Ultrasonic guided wave tomography (GWT) methods for the detection of corrosion and erosion damage in straight pipe sections are now well advanced. However, successful application of GWT to pipe bends has not yet been demonstrated due to the computational burden associated with the complex forward model required to simulate guided wave propagation through the bend. In a previous paper [Brath et al., IEEE Trans. Ultrason., Ferroelectr., Freq. Control, vol. 61, pp. 815-829, 2014], we have shown that the speed of the forward model can be increased by replacing the 3-D pipe bend with a 2-D rectangular domain in which guided wave propagation is formulated based on an artificially inhomogeneous and elliptically anisotropic (INELAN) acoustic model. This paper provides further experimental validation of the INLEAN model by studying the traveltime shifts caused by the introduction of shallow defects on the elbow of a pipe bend. Comparison between experiments and simulations confirms that a defect can be modeled as a phase velocity perturbation to the INLEAN velocity field with accuracy that is within the experimental error of the measurements. In addition, it is found that the sensitivity of traveltime measurements to the presence of damage decreases as the damage position moves from the interior side of the bend (intrados) to the exterior one (extrados). This effect is due to the nonuniform ray coverage obtainable when transmitting the guided wave signals with one ring array of sources on one side of the elbow and receiving with a second array on the other side.

Scalar localization of the electrode array after cochlear implantation: clinical experience using 64-slice multidetector computed tomography.

PubMed

Lane, John I; Witte, Robert J; Driscoll, Colin L W; Shallop, Jon K; Beatty, Charles W; Primak, Andrew N

2007-08-01

To use the improved resolution available with 64-slice multidetector computed tomography (MDCT) in vivo to localize the cochlear implant electrode array within the basal turn. Sixty-four-slice MDCT examinations of the temporal bones were retrospectively reviewed in 17 patients. Twenty-three implants were evaluated. Tertiary referral facility. All patients with previous cochlear implantation evaluated at our center between January 2004 and March 2006 were offered a computed tomographic examination as part of the study. In addition, preoperative computed tomographic examinations in patients being evaluated for a second bilateral device were included. Sixty-four-slice MDCT examination of the temporal bones. Localization of the electrode array within the basal turn from multiplanar reconstructions of the cochlea. Twenty-three implants were imaged in 17 patients. We were able to localize the electrode array within the scala tympani within the basal turn in 10 implants. In 3 implants, the electrode array was localized to the scala vestibuli. Migration of the electrode array from scala tympani to scala vestibuli was observed in three implants. Of the 7 implants in which localization of the electrode array was indeterminate, all had disease entities that obscured the definition of the normal cochlear anatomy. Sixty-four-slice MDCT with multiplanar reconstructions of the postoperative cochlea after cochlear implantation allows for accurate localization of the electrode array within the basal turn where normal cochlear anatomy is not obscured by the underlying disease process. Correlating the position of the electrode in the basal turn with surgical technique and implant design could be helpful in improving outcomes.

Preliminary Seismic Velocity Structure Results from Ambient Noise and Teleseismic Tomography: Laguna del Maule Volcanic Field, Chile

NASA Astrophysics Data System (ADS)

Wespestad, C.; Thurber, C. H.; Zeng, X.; Bennington, N. L.; Cardona, C.; Singer, B. S.

2016-12-01

Laguna del Maule Volcanic Field is a large, restless, rhyolitic system in the Southern Andes that is being heavily studied through several methods, including seismology, by a collaborative team of research institutions. A temporary array of 52 seismometers from OVDAS (the Southern Andean Volcano Observatory), PASSCAL (Portable Array Seismic Studies of the Continental Lithosphere), and the University of Wisconsin-Madison was used to collect the 1.3 years worth of data for this preliminary study. Ambient noise tomography uses surface wave dispersion data obtained from noise correlation functions (NCFs) between pairs of seismic stations, with one of each pair acting as a virtual source, in order to image the velocity structure in 3-D. NCFs were computed for hour-long time windows, and the final NCFs were obtained with phase-weighted stacking. The Frequency-Time Analysis technique was then utilized to measure group velocity between station pairs. NCFs were also analyzed to detect temporal changes in seismic velocity related to magmatic activity at the volcano. With the surface wave data from ambient noise, our small array aperture limits our modeling to the upper crust, so we employed teleseismic tomography to study deeper structures. For picking teleseismic arrivals, we tested two different correlation and stacking programs, which utilize adaptive stacking and multi-channel cross-correlation, to get relative arrival time data for a set of high quality events. Selected earthquakes were larger than magnitude 5 and between 30 and 95 degrees away from the center of the array. Stations that consistently show late arrivals may have a low velocity body beneath them, more clearly visualized via a 3-D tomographic model. Initial results from the two tomography methods indicate the presence of low-velocity zones at several depths. Better resolved velocity models will be developed as more data are acquired.

Monte Carlo simulation of simultaneous radiation detection in the hybrid tomography system ClearPET-XPAD3/CT

NASA Astrophysics Data System (ADS)

Dávila, H. Olaya; Sevilla, A. C.; Castro, H. F.; Martínez, S. A.

2016-07-01

Using the Geant4 based simulation framework SciFW1, a detailed simulation was performed for a detector array in the hybrid tomography prototype for small animals called ClearPET / XPAD, which was built in the Centre de Physique des Particules de Marseille. The detector system consists of an array of phoswich scintillation detectors: LSO (Lutetium Oxy-ortosilicate doped with cerium Lu2SiO5:Ce) and LuYAP (Lutetium Ortoaluminate of Yttrium doped with cerium Lu0.7Y0.3AlO3:Ce) for Positron Emission Tomography (PET) and hybrid pixel detector XPAD for Computed Tomography (CT). Simultaneous acquisition of deposited energy and the corresponding time - position for each recorded event were analyzed, independently, for both detectors. interference between detection modules for PET and CT. Information about amount of radiation reaching each phoswich crystal and XPAD detector using a phantom in order to study the effectiveness by radiation attenuation and influence the positioning of the radioactive source 22Na was obtained. The simulation proposed will improve distribution of detectors rings and interference values will be taken into account in the new versions of detectors.

Processing And Display Of Medical Three Dimensional Arrays Of Numerical Data Using Octree Encoding

NASA Astrophysics Data System (ADS)

Amans, Jean-Louis; Darier, Pierre

1986-05-01

imaging modalities such as X-Ray computerized Tomography (CT), Nuclear Medecine and Nuclear Magnetic Resonance can produce three-dimensional (3-D) arrays of numerical data of medical object internal structures. The analysis of 3-D data by synthetic generation of realistic images is an important area of computer graphics and imaging.

Isotropic-resolution linear-array-based photoacoustic computed tomography through inverse Radon transform

NASA Astrophysics Data System (ADS)

Li, Guo; Xia, Jun; Li, Lei; Wang, Lidai; Wang, Lihong V.

2015-03-01

Linear transducer arrays are readily available for ultrasonic detection in photoacoustic computed tomography. They offer low cost, hand-held convenience, and conventional ultrasonic imaging. However, the elevational resolution of linear transducer arrays, which is usually determined by the weak focus of the cylindrical acoustic lens, is about one order of magnitude worse than the in-plane axial and lateral spatial resolutions. Therefore, conventional linear scanning along the elevational direction cannot provide high-quality three-dimensional photoacoustic images due to the anisotropic spatial resolutions. Here we propose an innovative method to achieve isotropic resolutions for three-dimensional photoacoustic images through combined linear and rotational scanning. In each scan step, we first elevationally scan the linear transducer array, and then rotate the linear transducer array along its center in small steps, and scan again until 180 degrees have been covered. To reconstruct isotropic three-dimensional images from the multiple-directional scanning dataset, we use the standard inverse Radon transform originating from X-ray CT. We acquired a three-dimensional microsphere phantom image through the inverse Radon transform method and compared it with a single-elevational-scan three-dimensional image. The comparison shows that our method improves the elevational resolution by up to one order of magnitude, approaching the in-plane lateral-direction resolution. In vivo rat images were also acquired.

In vivo examination of the cortical cytoskeleton in multiciliated cells using electron tomography.

PubMed

Clare, Daniel K; Dumoux, Maud; Delacour, Delphine

2015-01-01

Multiciliated cells are characterized by coordinated arrays of motile cilia. In the respiratory tract, the maintenance of this array is essential to ensure proper ciliary and mucus clearance. The establishment and the maintenance of the ciliary set are mediated by the correct positioning of basal bodies at the cell cortex. While microtubule and actin cytoskeletons have been reported to regulate basal body lattices, an understanding of their detailed organization was missing until recently. Here, we describe how electron tomography can highlight the arrangement of the cytoskeletal networks and their interplay with basal bodies in ciliated cells in their tissular environment. Thanks to this approach, information in fine detail on large parts of the cell, dense in organelles, is provided. In combination with other approaches, such as transgenic animal models, electron tomography constitutes a powerful technique giving an overview of tissues and cells concomitantly with acquisition of three-dimensional detail. Copyright © 2015 Elsevier Inc. All rights reserved.

Array Detector Modules for Spent Fuel Verification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bolotnikov, Aleksey

Brookhaven National Laboratory (BNL) proposes to evaluate the arrays of position-sensitive virtual Frisch-grid (VFG) detectors for passive gamma-ray emission tomography (ET) to verify the spent fuel in storage casks before storing them in geo-repositories. Our primary objective is to conduct a preliminary analysis of the arrays capabilities and to perform field measurements to validate the effectiveness of the proposed array modules. The outcome of this proposal will consist of baseline designs for the future ET system which can ultimately be used together with neutrons detectors. This will demonstrate the usage of this technology in spent fuel storage casks.

Ambient noise adjoint tomography for a linear array in North China

NASA Astrophysics Data System (ADS)

Zhang, C.; Yao, H.; Liu, Q.; Yuan, Y. O.; Zhang, P.; Feng, J.; Fang, L.

2017-12-01

Ambient noise tomography based on dispersion data and ray theory has been widely utilized for imaging crustal structures. In order to improve the inversion accuracy, ambient noise tomography based on the 3D adjoint approach or full waveform inversion has been developed recently, however, the computational cost is tremendous. In this study we present 2D ambient noise adjoint tomography for a linear array in north China with significant computational efficiency compared to 3D ambient noise adjoint tomography. During the preprocessing, we first convert the observed data in 3D media, i.e., surface-wave empirical Green's functions (EGFs) from ambient noise cross-correlation, to the reconstructed EGFs in 2D media using a 3D/2D transformation scheme. Different from the conventional steps of measuring phase dispersion, the 2D adjoint tomography refines 2D shear wave speeds along the profile directly from the reconstructed Rayleigh wave EGFs in the period band 6-35s. With the 2D initial model extracted from the 3D model from traditional ambient noise tomography, adjoint tomography updates the model by minimizing the frequency-dependent Rayleigh wave traveltime misfits between the reconstructed EGFs and synthetic Green function (SGFs) in 2D media generated by the spectral-element method (SEM), with a preconditioned conjugate gradient method. The multitaper traveltime difference measurement is applied in four period bands during the inversion: 20-35s, 15-30s, 10-20s and 6-15s. The recovered model shows more detailed crustal structures with pronounced low velocity anomaly in the mid-lower crust beneath the junction of Taihang Mountains and Yin-Yan Mountains compared with the initial model. This low velocity structure may imply the possible intense crust-mantle interactions, probably associated with the magmatic underplating during the Mesozoic to Cenozoic evolution of the region. To our knowledge, it's first time that ambient noise adjoint tomography is implemented in 2D media. Considering the intensive computational cost and storage of 3D adjoint tomography, this 2D ambient noise adjoint tomography has potential advantages to get high-resolution 2D crustal structures with limited computational resource.

Multi-segment detector array for hybrid reflection-mode ultrasound and optoacoustic tomography (Conference Presentation)

NASA Astrophysics Data System (ADS)

Merčep, Elena; Burton, Neal C.; Deán-Ben, Xosé Luís.; Razansky, Daniel

2017-02-01

The complementary contrast of the optoacoustic (OA) and pulse-echo ultrasound (US) modalities makes the combined usage of these imaging technologies highly advantageous. Due to the different physical contrast mechanisms development of a detector array optimally suited for both modalities is one of the challenges to efficient implementation of a single OA-US imaging device. We demonstrate imaging performance of the first hybrid detector array whose novel design, incorporating array segments of linear and concave geometry, optimally supports image acquisition in both reflection-mode ultrasonography and optoacoustic tomography modes. Hybrid detector array has a total number of 256 elements and three segments of different geometry and variable pitch size: a central 128-element linear segment with pitch of 0.25mm, ideally suited for pulse-echo US imaging, and two external 64-elements segments with concave geometry and 0.6mm pitch optimized for OA image acquisition. Interleaved OA and US image acquisition with up to 25 fps is facilitated through a custom-made multiplexer unit. Spatial resolution of the transducer was characterized in numerical simulations and validated in phantom experiments and comprises 230 and 300 μm in the respective OA and US imaging modes. Imaging performance of the multi-segment detector array was experimentally shown in a series of imaging sessions with healthy volunteers. Employing mixed array geometries allows at the same time achieving excellent OA contrast with a large field of view, and US contrast for complementary structural features with reduced side-lobes and improved resolution. The newly designed hybrid detector array that comprises segments of linear and concave geometries optimally fulfills requirements for efficient US and OA imaging and may expand the applicability of the developed hybrid OPUS imaging technology and accelerate its clinical translation.

Objective Assessment and Design Improvement of a Staring, Sparse Transducer Array by the Spatial Crosstalk Matrix for 3D Photoacoustic Tomography

PubMed Central

Kosik, Ivan; Raess, Avery

2015-01-01

Accurate reconstruction of 3D photoacoustic (PA) images requires detection of photoacoustic signals from many angles. Several groups have adopted staring ultrasound arrays, but assessment of array performance has been limited. We previously reported on a method to calibrate a 3D PA tomography (PAT) staring array system and analyze system performance using singular value decomposition (SVD). The developed SVD metric, however, was impractical for large system matrices, which are typical of 3D PAT problems. The present study consisted of two main objectives. The first objective aimed to introduce the crosstalk matrix concept to the field of PAT for system design. Figures-of-merit utilized in this study were root mean square error, peak signal-to-noise ratio, mean absolute error, and a three dimensional structural similarity index, which were derived between the normalized spatial crosstalk matrix and the identity matrix. The applicability of this approach for 3D PAT was validated by observing the response of the figures-of-merit in relation to well-understood PAT sampling characteristics (i.e. spatial and temporal sampling rate). The second objective aimed to utilize the figures-of-merit to characterize and improve the performance of a near-spherical staring array design. Transducer arrangement, array radius, and array angular coverage were the design parameters examined. We observed that the performance of a 129-element staring transducer array for 3D PAT could be improved by selection of optimal values of the design parameters. The results suggested that this formulation could be used to objectively characterize 3D PAT system performance and would enable the development of efficient strategies for system design optimization. PMID:25875177

Sensitivity study of an ultrasound coupled transrectal electrical Impedance Tomography system for prostate imaging

NASA Astrophysics Data System (ADS)

Wan, Y.; Halter, R.; Borsic, A.; Manwaring, P.; Hartov, A.; Paulsen, K.

2010-04-01

In 2009, prostate cancer ranks as the most common cancer and the second most fatal cancer in men in the United States. Unfortunately, the current clinical diagnostic methods (e.g. prostate-specific antigen (PSA), digital rectal examination, endorectal MRI, transrectal ultrasound, biopsy) used for detecting and staging prostate cancer are limited. It has been shown that cancerous prostate tissue has significantly different electrical properties when compared to benign tissues. Based on these electrical property findings, a TransRectal Electrical Impedance Tomography (TREIT) system is proposed as a novel prostate imaging modality. The TREIT system is comprised of an array of electrodes interfaced with a clinical TransRectal UltraSound (TRUS) probe. We evaluate this imaging system through series of phantom imaging experiments to assess the system's ability to image high and low contrast objects at various positions. We found that the TREIT system can easily discern high contrast inclusions of 1 cm in diameter at distances centered at 2 times the radius of the TREIT probe away from the probe surface. Furthermore, this technology's ability to detect low contrast inclusions suggests that it has the potential to successfully detect prostate cancer.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, P; Cammin, J; Solberg, T

Purpose: Proton radiography and proton computed tomography (PCT) can be used to measure proton stopping power directly. However, practical and cost effective proton imaging detectors are not widely available. In this study, the authors investigated the feasibility of proton imaging using a silicon diode array. Methods: A one-dimensional silicon-diode detector array (1DSDA) was aligned with the central axis (CAX) of the proton beam. Polymethyl methacrylate (PMMA) slabs were used to find the correspondence between the water equivalent thickness (WET) and 1DSDA channel number. 2D proton radiographs (PR) were obtained by translation and rotation of a phantom relative to CAX whilemore » the proton nozzle and 1DSDA were kept stationary. A PCT image of one slice of the phantom was reconstructed using filtered backprojection. Results: PR and PCT images of the PMMA cube were successfully acquired using the 1DSDA. The WET of the phantom was measured using PR data with an accuracy of 4.2% or better. Structures down to 1 mm in size could be resolved. Reconstruction of a PCT image showed very good agreement with simulation. Limitations in spatial resolution are attributed to limited spatial sampling, beam collimation, and proton scatter. Conclusion: The results demonstrate the feasibility of using silicon diode arrays for proton imaging. Such a device can potentially offer fast image acquisition, high spatial and energy resolution for PR and PCT.« less

Material characterization using ultrasound tomography

NASA Astrophysics Data System (ADS)

Falardeau, Timothe; Belanger, Pierre

2018-04-01

Characterization of material properties can be performed using a wide array of methods e.g. X-ray diffraction or tensile testing. Each method leads to a limited set of material properties. This paper is interested in using ultrasound tomography to map speed of sound inside a material sample. The velocity inside the sample is directly related to its elastic properties. Recent develop-ments in ultrasound diffraction tomography have enabled velocity mapping of high velocity contrast objects using a combination of bent-ray time-of-flight tomography and diffraction tomography. In this study, ultrasound diffraction tomography was investigated using simulations in human bone phantoms. A finite element model was developed to assess the influence of the frequency, the number of transduction positions and the distance from the sample as well as to adapt the imaging algorithm. The average velocity in both regions of the bone phantoms were within 5% of the true value.

Three-dimensional cross point readout detector design for including depth information

NASA Astrophysics Data System (ADS)

Lee, Seung-Jae; Baek, Cheol-Ha

2018-04-01

We designed a depth-encoding positron emission tomography (PET) detector using a cross point readout method with wavelength-shifting (WLS) fibers. To evaluate the characteristics of the novel detector module and the PET system, we used the DETECT2000 to perform optical photon transport in the crystal array. The GATE was also used. The detector module is made up of four layers of scintillator arrays, the five layers of WLS fiber arrays, and two sensor arrays. The WLS fiber arrays in each layer cross each other to transport light to each sensor array. The two sensor arrays are coupled to the forward and left sides of the WLS fiber array, respectively. The identification of three-dimensional pixels was determined using a digital positioning algorithm. All pixels were well decoded, with the system resolution ranging from 2.11 mm to 2.29 mm at full width at half maximum (FWHM).

Distributed RF Tomography for Tunnel Detection: Suitable Inversion Schemes

DTIC Science & Technology

2009-01-01

methods, ranging from seismic to electromagnetic waves, or from gravity to optics, from impedance tomography to magnetotellurics, no technique...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Borehole GPR, which may...one manner to different targets (when targets are well-resolved). In particular, the wavefront generated by the array , when excited by one of these

Viewing Welds By Computer Tomography

NASA Technical Reports Server (NTRS)

Pascua, Antonio G.; Roy, Jagatjit

1990-01-01

Computer tomography system used to inspect welds for root penetration. Source illuminates rotating welded part with fan-shaped beam of x rays or gamma rays. Detectors in circular array on opposite side of part intercept beam and convert it into electrical signals. Computer processes signals into image of cross section of weld. Image displayed on video monitor. System offers only nondestructive way to check penetration from outside when inner surfaces inaccessible.

Do rewardless orchids show a positive relationship between phenotypic diversity and reproductive success?

PubMed

Smithson, Ann; Juillet, Nicolas; Macnair, Mark R; Gigord, Luc D B

2007-02-01

Among rewardless orchids, pollinator sampling behavior has been suggested to drive a positive relationship between population phenotypic variability and absolute reproductive success, and hence population fitness. We tested this hypothesis by constructing experimental arrays using the rewardless orchid Dactylorhiza sambucina, which is dimorphic for corolla color. We found no evidence that polymorphic arrays had higher mean reproductive success than monomorphic arrays for pollinia removal, pollen deposition, or fruit set. For pollinia removal, monomorphic yellow arrays had significantly greater reproductive success, and monomorphic red the least. A tendency for yellow arrays to have higher pollen deposition was also found. We argue that differential population fitness was most likely to reflect differential numbers of pollinators attracted to arrays, through preferential long-distance attraction to arrays with yellow inflorescences. Correlative studies of absolute reproductive success in 52 populations of D. sambucina supported our experimental results. To our knowledge this is the first study to suggest that attraction of a greater number of pollinators to rewardless orchids may be of greater functional importance to population fitness, and thus ecology and conservation, than are the behavioral sequences of individual pollinators.

Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo.

PubMed

Xia, Jun; Chatni, Muhammad R; Maslov, Konstantin; Guo, Zijian; Wang, Kun; Anastasio, Mark; Wang, Lihong V

2012-05-01

We report a novel small-animal whole-body imaging system called ring-shaped confocal photoacoustic computed tomography (RC-PACT). RC-PACT is based on a confocal design of free-space ring-shaped light illumination and 512-element full-ring ultrasonic array signal detection. The free-space light illumination maximizes the light delivery efficiency, and the full-ring signal detection ensures a full two-dimensional view aperture for accurate image reconstruction. Using cylindrically focused array elements, RC-PACT can image a thin cross section with 0.10 to 0.25 mm in-plane resolutions and 1.6  s/frame acquisition time. By translating the mouse along the elevational direction, RC-PACT provides a series of cross-sectional images of the brain, liver, kidneys, and bladder.

Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo

NASA Astrophysics Data System (ADS)

Xia, Jun; Chatni, Muhammad R.; Maslov, Konstantin; Guo, Zijian; Wang, Kun; Anastasio, Mark; Wang, Lihong V.

2012-05-01

We report a novel small-animal whole-body imaging system called ring-shaped confocal photoacoustic computed tomography (RC-PACT). RC-PACT is based on a confocal design of free-space ring-shaped light illumination and 512-element full-ring ultrasonic array signal detection. The free-space light illumination maximizes the light delivery efficiency, and the full-ring signal detection ensures a full two-dimensional view aperture for accurate image reconstruction. Using cylindrically focused array elements, RC-PACT can image a thin cross section with 0.10 to 0.25 mm in-plane resolutions and 1.6 s/frame acquisition time. By translating the mouse along the elevational direction, RC-PACT provides a series of cross-sectional images of the brain, liver, kidneys, and bladder.

Large depth high-precision FMCW tomography using a distributed feedback laser array

NASA Astrophysics Data System (ADS)

DiLazaro, Thomas; Nehmetallah, George

2018-02-01

Swept-source optical coherence tomography (SS-OCT) has been widely employed in the medical industry for the high resolution imaging of subsurface biological structures. SS-OCT typically exhibits axial resolutions on the order of tens of microns at speeds of hundreds of kilohertz. Using the same coherent heterodyne detection technique, frequency modulated continuous wave (FMCW) ladar has been used for highly precise ranging for distances up to kilometers. Distributed feedback lasers (DFBs) have been used as a simple and inexpensive source for FMCW ranging. Here, we use a bandwidth-combined DFB array for sub-surface volume imaging at a 27 μm axial resolution over meters of distance. 2D and 3D tomographic images of several semi-transparent and diffuse objects at distances up to 10 m will be presented.

SU-E-I-107: Suitability of Various Radiation Detectors Used in Radiation Therapy for X-Ray Dosimetry in Computed Tomography.

PubMed

Liebmann, M; Poppe, B; von Boetticher, H

2012-06-01

Assessment of suitability for X-ray dosimetry in computed tomography of various ionization chambers, diodes and two-dimensional detector arrays primarily used in radiation therapy. An Oldelft X-ray simulation unit was used to irradiate PTW 60008, 60012 dosimetry diodes, PTW 23332, 31013, 31010, 31006 axial symmetrical ionization chambers, PTW 23343, 34001 plane parallel ionization chambers and PTW Starcheck and 2D-Array seven29 as well as a prototype Farmer chamber with a copper wall. Peak potential was varied from 50 kV up to 125 kV and beam qualities were quantified through half-value-layer measurements. Energy response was investigated free in air as well as in 2 cm depth in a solid water phantom and refers to a manufacturer calibrated PTW 60004 diode for kV-dosimetry. The thimble ionization chambers PTW 31010, 31013, the uncapsuled diode PTW 60012 and the PTW 2D-Array seven29 exhibit an energy response deviation in the investigated energy region of approximately 10% or lower thus proving good usability in X-ray dosimetry if higher spatial resolution is needed or rotational irradiations occur. It could be shown that in radiation therapy routinely used detectors are usable in a much lower energy region. The rotational symmetry is of advantage in computed tomography dosimetry and enables dose profile as well as point dose measurements in a suitable phantom for estimation of organ doses. Additional the PTW 2D-Array seven29 can give a quick overview of radiation fields in non-rotating tasks. © 2012 American Association of Physicists in Medicine.

1-D Metal Nanobead Arrays within Encapsulated Nanowires via a Red-Ox-Induced Dewetting: Mechanism Study by Atom-Probe Tomography.

PubMed

Sun, Zhiyuan; Tzaguy, Avra; Hazut, Ori; Lauhon, Lincoln J; Yerushalmi, Roie; Seidman, David N

2017-12-13

Metal nanoparticle arrays are excellent candidates for a variety of applications due to the versatility of their morphology and structure at the nanoscale. Bottom-up self-assembly of metal nanoparticles provides an important complementary alternative to the traditional top-down lithography method and makes it possible to assemble structures with higher-order complexity, for example, nanospheres, nanocubes, and core-shell nanostructures. Here we present a mechanism study of the self-assembly process of 1-D noble metal nanoparticles arrays, composed of Au, Ag, and AuAg alloy nanoparticles. These are prepared within an encapsulated germanium nanowire, obtained by the oxidation of a metal-germanium nanowire hybrid structure. The resulting structure is a 1-D array of equidistant metal nanoparticles with the same diameter, the so-called nanobead (NB) array structure. Atom-probe tomography and transmission electron microscopy were utilized to investigate the details of the morphological and chemical evolution during the oxidation of the encapsulated metal-germanium nanowire hybrid-structures. The self-assembly of nanoparticles relies on the formation of a metal-germanium liquid alloy and the migration of the liquid alloy into the nanowire, followed by dewetting of the liquid during shape-confined oxidation where the liquid column breaks-up into nanoparticles due to the Plateau-Rayleigh instability. Our results demonstrate that the encapsulating oxide layer serves as a structural scaffold, retaining the overall shape during the eutectic liquid formation and demonstrates the relationship between the oxide mechanical properties and the final structural characteristics of the 1-D arrays. The mechanistic details revealed here provide a versatile tool-box for the bottom-up fabrication of 1-D arrays nanopatterning that can be modified for multiple applications according to the RedOx properties of the material system components.

Plenoptic projection fluorescence tomography.

PubMed

Iglesias, Ignacio; Ripoll, Jorge

2014-09-22

A new method to obtain the three-dimensional localization of fluorochrome distributions in micrometric samples is presented. It uses a microlens array coupled to the image port of a standard microscope to obtain tomographic data by a filtered back-projection algorithm. Scanning of the microlens array is proposed to obtain a dense data set for reconstruction. Simulation and experimental results are shown and the implications of this approach in fast 3D imaging are discussed.

Digital Radiography and Computed Tomography Project -- Fully Integrated Linear Detector ArrayStatus Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tim Roney; Robert Seifert; Bob Pink

2011-09-01

The field-portable Digital Radiography and Computed Tomography (DRCT) x-ray inspection systems developed for the Project Manager for NonStockpile Chemical Materiel (PMNSCM) over the past 13 years have used linear diode detector arrays from two manufacturers; Thomson and Thales. These two manufacturers no longer produce this type of detector. In the interest of insuring the long term viability of the portable DRCT single munitions inspection systems and to improve the imaging capabilities, this project has been investigating improved, commercially available detectors. During FY-10, detectors were evaluated and one in particular, manufactured by Detection Technologies (DT), Inc, was acquired for possible integrationmore » into the DRCT systems. The remainder of this report describes the work performed in FY-11 to complete evaluations and fully integrate the detector onto a representative DRCT platform.« less

Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography

PubMed Central

Weiler, Nicholas C; Collman, Forrest; Vogelstein, Joshua T; Burns, Randal; Smith, Stephen J

2014-01-01

A major question in neuroscience is how diverse subsets of synaptic connections in neural circuits are affected by experience dependent plasticity to form the basis for behavioral learning and memory. Differences in protein expression patterns at individual synapses could constitute a key to understanding both synaptic diversity and the effects of plasticity at different synapse populations. Our approach to this question leverages the immunohistochemical multiplexing capability of array tomography (ATomo) and the columnar organization of mouse barrel cortex to create a dataset comprising high resolution volumetric images of spared and deprived cortical whisker barrels stained for over a dozen synaptic molecules each. These dataset has been made available through the Open Connectome Project for interactive online viewing, and may also be downloaded for offline analysis using web, Matlab, and other interfaces. PMID:25977797

Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.

PubMed

Weiler, Nicholas C; Collman, Forrest; Vogelstein, Joshua T; Burns, Randal; Smith, Stephen J

2014-01-01

A major question in neuroscience is how diverse subsets of synaptic connections in neural circuits are affected by experience dependent plasticity to form the basis for behavioral learning and memory. Differences in protein expression patterns at individual synapses could constitute a key to understanding both synaptic diversity and the effects of plasticity at different synapse populations. Our approach to this question leverages the immunohistochemical multiplexing capability of array tomography (ATomo) and the columnar organization of mouse barrel cortex to create a dataset comprising high resolution volumetric images of spared and deprived cortical whisker barrels stained for over a dozen synaptic molecules each. These dataset has been made available through the Open Connectome Project for interactive online viewing, and may also be downloaded for offline analysis using web, Matlab, and other interfaces.

ACOUSTICAL IMAGING AND MECHANICAL PROPERTIES OF SOFT ROCK AND MARINE SEDIMENTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thurman E. Scott, Jr., Ph.D.; Younane Abousleiman, Ph.D.; Musharraf Zaman, Ph.D., P.E.

2002-11-18

During the sixth quarter of this research project the research team developed a method and the experimental procedures for acquiring the data needed for ultrasonic tomography of rock core samples under triaxial stress conditions as outlined in Task 10. Traditional triaxial compression experiments, where compressional and shear wave velocities are measured, provide little or no information about the internal spatial distribution of mechanical damage within the sample. The velocities measured between platen-to-platen or sensor-to-sensor reflects an averaging of all the velocities occurring along that particular raypath across the boundaries of the rock. The research team is attempting to develop andmore » refine a laboratory equivalent of seismic tomography for use on rock samples deformed under triaxial stress conditions. Seismic tomography, utilized for example in crosswell tomography, allows an imaging of the velocities within a discrete zone within the rock. Ultrasonic or acoustic tomography is essentially the extension of that field technology applied to rock samples deforming in the laboratory at high pressures. This report outlines the technical steps and procedures for developing this technology for use on weak, soft chalk samples. Laboratory tests indicate that the chalk samples exhibit major changes in compressional and shear wave velocities during compaction. Since chalk is the rock type responsible for the severe subsidence and compaction in the North Sea it was selected for the first efforts at tomographic imaging of soft rocks. Field evidence from the North Sea suggests that compaction, which has resulted in over 30 feet of subsidence to date, is heterogeneously distributed within the reservoir. The research team will attempt to image this very process in chalk samples. The initial tomographic studies (Scott et al., 1994a,b; 1998) were accomplished on well cemented, competent rocks such as Berea sandstone. The extension of the technology to weaker samples is more difficult but potentially much more rewarding. The chalk, since it is a weak material, also attenuates wave propagation more than other rock types. Three different types of sensors were considered (and tested) for the tomographic imaging project: 600 KHz PZT, 1 MHz PZT, and PVDF film sensors. 600 KHz PZT crystals were selected because they generated a sufficiently high amplitude pulse to propagate across the damaged chalk. A number of different configurations were considered for placement of the acoustic arrays. It was decided after preliminary testing that the most optimum arrangement of the acoustic sensors was to place three arrays of sensors, with each array containing twenty sensors, around the sample. There would be two horizontal arrays to tomographically image two circular cross-sectional planes through the rock core sample. A third array would be vertically oriented to provide a vertical cross-sectional view of the sample. A total of 260 acoustic raypaths would be shot and acquired in the horizontal acoustic array to create each horizontal tomographic image. The sensors can be used as both acoustic sources or as acoustic each of the 10 pulsers to the 10 receivers.« less

An Efficient Image Recovery Algorithm for Diffraction Tomography Systems

NASA Technical Reports Server (NTRS)

Jin, Michael Y.

1993-01-01

A diffraction tomography system has potential application in ultrasonic medical imaging area. It is capable of achieving imagery with the ultimate resolution of one quarter the wavelength by collecting ultrasonic backscattering data from a circular array of sensors and reconstructing the object reflectivity using a digital image recovery algorithm performed by a computer. One advantage of such a system is that is allows a relatively lower frequency wave to penetrate more deeply into the object and still achieve imagery with a reasonable resolution. An efficient image recovery algorithm for the diffraction tomography system was originally developed for processing a wide beam spaceborne SAR data...

Conceptual design and optimization of a plastic scintillator array for 2D tomography using a compact D-D fast neutron generator.

PubMed

Adams, Robert; Zboray, Robert; Cortesi, Marco; Prasser, Horst-Michael

2014-04-01

A conceptual design optimization of a fast neutron tomography system was performed. The system is based on a compact deuterium-deuterium fast neutron generator and an arc-shaped array of individual neutron detectors. The array functions as a position sensitive one-dimensional detector allowing tomographic reconstruction of a two-dimensional cross section of an object up to 10 cm across. Each individual detector is to be optically isolated and consists of a plastic scintillator and a Silicon Photomultiplier for measuring light produced by recoil protons. A deterministic geometry-based model and a series of Monte Carlo simulations were used to optimize the design geometry parameters affecting the reconstructed image resolution. From this, it is expected that with an array of 100 detectors a reconstructed image resolution of ~1.5mm can be obtained. Other simulations were performed in order to optimize the scintillator depth (length along the neutron path) such that the best ratio of direct to scattered neutron counts is achieved. This resulted in a depth of 6-8 cm and an expected detection efficiency of 33-37%. Based on current operational capabilities of a prototype neutron generator being developed at the Paul Scherrer Institute, planned implementation of this detector array design should allow reconstructed tomograms to be obtained with exposure times on the order of a few hours. Copyright © 2014 Elsevier Ltd. All rights reserved.

Photonic Breast Tomography and Tumor Aggressiveness Assessment

DTIC Science & Technology

2010-07-01

removal of breast tumours (Specific Aim 4). While the TROT approach [7] has been introduced in other areas, such as, array processing for acoustic and...to the time-reversal matrix used in the general area of array processing for acoustic and radar time-reversal imaging [15]. The eigenvalue equation...spectrum [Eq.(1) in Ref. 8] is calculated directly for all voxels in the sample using the vector subspace method, Multiple Signal Classification ( MUSIC

Forward modeling to investigate inversion artifacts resulting from time-lapse electrical resistivity tomography during rainfall simulations

NASA Astrophysics Data System (ADS)

Carey, Austin M.; Paige, Ginger B.; Carr, Bradley J.; Dogan, Mine

2017-10-01

Time-lapse electrical resistivity tomography (ERT) is commonly used as a minimally invasive tool to study infiltration processes. In 2014, we conducted field studies coupling variable intensity rainfall simulation with high-resolution ERT to study the real-time partitioning of rainfall into surface and subsurface response. The significant contrast in resistivity in the subsurface from large changes in subsurface moisture resulted in artifacts during the inversion process of the time-lapse ERT data collected using a dipole-dipole electrode array. These artifacts, which are not representative of real subsurface moisture dynamics, have been shown to arise during time-lapse inversion of ERT data and may be subject to misinterpretation. Forward modeling of the infiltration process post field experiments using a two-layer system (saprolite overlain by a soil layer) was used to generate synthetic datasets. The synthetic data were used to investigate the influence of both changes in volumetric moisture content and electrode configuration on the development of the artifacts identified in the field datasets. For the dipole-dipole array, we found that a decrease in the resistivity of the bottom layer by 67% resulted in a 50% reduction in artifact development. Artifacts for the seven additional array configurations tested, ranged from a 19% increase in artifact development (using an extended dipole-dipole array) to as much as a 96% decrease in artifact development (using a wenner-alpha array), compared to that of the dipole-dipole array. Moreover, these arrays varied in their ability to accurately delineate the infiltration front. Model results showed that the modified pole-dipole array was able to accurately image the infiltration zone and presented fewer artifacts for our experiments. In this study, we identify an optimal array type for imaging rainfall-infiltration dynamics that reduces artifacts. The influence of moisture contrast between the infiltrating water and the bulk subsurface material was characterized and shown to be a major factor in contributing to artifact development. Through forward modeling, this study highlights the importance of considering array type and subsurface moisture conditions when using time-lapse resistivity to obtain reliable estimates of vadose zone flow processes during rainfall-infiltration events.

Preclinical positron emission tomography scanner based on a monolithic annulus of scintillator: initial design study.

PubMed

Stolin, Alexander V; Martone, Peter F; Jaliparthi, Gangadhar; Raylman, Raymond R

2017-01-01

Positron emission tomography (PET) scanners designed for imaging of small animals have transformed translational research by reducing the necessity to invasively monitor physiology and disease progression. Virtually all of these scanners are based on the use of pixelated detector modules arranged in rings. This design, while generally successful, has some limitations. Specifically, use of discrete detector modules to construct PET scanners reduces detection sensitivity and can introduce artifacts in reconstructed images, requiring the use of correction methods. To address these challenges, and facilitate measurement of photon depth-of-interaction in the detector, we investigated a small animal PET scanner (called AnnPET) based on a monolithic annulus of scintillator. The scanner was created by placing 12 flat facets around the outer surface of the scintillator to accommodate placement of silicon photomultiplier arrays. Its performance characteristics were explored using Monte Carlo simulations and sections of the NEMA NU4-2008 protocol. Results from this study revealed that AnnPET's reconstructed spatial resolution is predicted to be [Formula: see text] full width at half maximum in the radial, tangential, and axial directions. Peak detection sensitivity is predicted to be 10.1%. Images of simulated phantoms (mini-hot rod and mouse whole body) yielded promising results, indicating the potential of this system for enhancing PET imaging of small animals.

The Combined Radio Interferometry and COSMIC Experiment in Tomography (CRICKET) Campaign

NASA Astrophysics Data System (ADS)

Dymond, Kenneth; Coker, Clayton; Bernhardt, Paul; Cohen, Aaron; Crane, Patrick; Kassim, Namir; Lazio, Joseph; Weiler, Kurt; Watts, Christopher; Rickard, Lee J.; Taylor, Greg; Schinzel, Frank; Philstrom, Ylva; Close, Sigrid; Colestock, Patrick; Myers, Steve; Datta, Abirhup

We report on the Combined Radio Interferometry and COSMIC Experiment in Tomography Campaign (CRICKET) held on September 15 and 17, 2007. The experiment used the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC also known as FORMOSAT-3) in conjunction with the Very Large Array radio telescope, located near Socorro, NM, to study the ionosphere from the global scale down to the regional scale. Each COSMIC satellite includes three instruments capable of measuring the ionosphere: the Tiny Ionospheric Photometer (TIP), a UV radiometer; the GPS Occultation experiment (GOX), a dual-frequency GPS occultation receiver; and the Tri-band Beacon (TBB), a three frequency coherently radiating radio beacon. These three instruments have been demonstrated to be a powerful means for characterizing the global-scale ionosphere. The VLA when deployed at its largest extent and while operating at 73.8 MHz is incredibly sensitive to relative total electron content variations of the regional ionosphere over about a 30-100 km diameter area. In this work, we concentrate on the first set of observations on September 15, 2007 at approximately 0830 UT. We have successfully married these heterogeneous data sets, using a tomographic data fusion approach, to produce a consistent ionospheric specification from the global scale down to the regional scale.

Insertion characteristics and placement of the Mid-Scala electrode array in human temporal bones using detailed cone beam computed tomography.

PubMed

Dietz, Aarno; Gazibegovic, Dzemal; Tervaniemi, Jyrki; Vartiainen, Veli-Matti; Löppönen, Heikki

2016-12-01

The aim of this study was to evaluate the insertion results and placement of the new Advanced Bionics HiFocus Mid-Scala (HFms) electrode array, inserted through the round window membrane, in eight fresh human temporal bones using cone beam computed tomography (CBCT). Pre- and post-insertion CBCT scans were registered to create a 3D reconstruction of the cochlea with the array inserted. With an image fusion technique both the bony edges of the cochlea and the electrode array in situ could accurately be determined, thus enabling to identify the exact position of the electrode array within the scala tympani. Vertical and horizontal scalar location was measured at four points along the cochlea base at an angular insertion depth of 90°, 180° and 270° and at electrode 16, the most basal electrode. Smooth insertion through the round window membrane was possible in all temporal bones. The imaging results showed that there were no dislocations from the scala tympani into the scala vestibule. The HFms electrode was positioned in the middle of the scala along the whole electrode array in three out of the eight bones and in 62 % of the individual locations measured along the base of the cochlea. In only one cochlea a close proximity of the electrode with the basilar membrane was observed, indicating possible contact with the basilar membrane. The results and assessments presented in this study appear to be highly accurate. Although a further validation including histopathology is needed, the image fusion technique described in this study represents currently the most accurate method for intracochlear electrode assessment obtainable with CBCT.

X-ray analysis of electron Bernstein wave heating in MST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seltzman, A. H., E-mail: seltzman@wisc.edu; Anderson, J. K.; DuBois, A. M.

2016-11-15

A pulse height analyzing x-ray tomography system has been developed to detect x-rays from electron Bernstein wave heated electrons in the Madison symmetric torus reversed field pinch (RFP). Cadmium zinc telluride detectors are arranged in a parallel beam array with two orthogonal multi-chord detectors that may be used for tomography. In addition a repositionable 16 channel fan beam camera with a 55° field of view is used to augment data collected with the Hard X-ray array. The chord integrated signals identify target emission from RF heated electrons striking a limiter located 12° toroidally away from the RF injection port. Thismore » provides information on heated electron spectrum, transport, and diffusion. RF induced x-ray emission from absorption on harmonic electron cyclotron resonances in low current (<250 kA) RFP discharges has been observed.« less

Advanced Fast 3-D Electromagnetic Solver for Microwave Tomography Imaging.

PubMed

Simonov, Nikolai; Kim, Bo-Ra; Lee, Kwang-Jae; Jeon, Soon-Ik; Son, Seong-Ho

2017-10-01

This paper describes a fast-forward electromagnetic solver (FFS) for the image reconstruction algorithm of our microwave tomography system. Our apparatus is a preclinical prototype of a biomedical imaging system, designed for the purpose of early breast cancer detection. It operates in the 3-6-GHz frequency band using a circular array of probe antennas immersed in a matching liquid; it produces image reconstructions of the permittivity and conductivity profiles of the breast under examination. Our reconstruction algorithm solves the electromagnetic (EM) inverse problem and takes into account the real EM properties of the probe antenna array as well as the influence of the patient's body and that of the upper metal screen sheet. This FFS algorithm is much faster than conventional EM simulation solvers. In comparison, in the same PC, the CST solver takes ~45 min, while the FFS takes ~1 s of effective simulation time for the same EM model of a numerical breast phantom.

From a meso- to micro-scale connectome: array tomography and mGRASP

PubMed Central

Rah, Jong-Cheol; Feng, Linqing; Druckmann, Shaul; Lee, Hojin; Kim, Jinhyun

2015-01-01

Mapping mammalian synaptic connectivity has long been an important goal of neuroscience because knowing how neurons and brain areas are connected underpins an understanding of brain function. Meeting this goal requires advanced techniques with single synapse resolution and large-scale capacity, especially at multiple scales tethering the meso- and micro-scale connectome. Among several advanced LM-based connectome technologies, Array Tomography (AT) and mammalian GFP-Reconstitution Across Synaptic Partners (mGRASP) can provide relatively high-throughput mapping synaptic connectivity at multiple scales. AT- and mGRASP-assisted circuit mapping (ATing and mGRASPing), combined with techniques such as retrograde virus, brain clearing techniques, and activity indicators will help unlock the secrets of complex neural circuits. Here, we discuss these useful new tools to enable mapping of brain circuits at multiple scales, some functional implications of spatial synaptic distribution, and future challenges and directions of these endeavors. PMID:26089781

Compact conscious animal positron emission tomography scanner

DOEpatents

Schyler, David J.; O'Connor, Paul; Woody, Craig; Junnarkar, Sachin Shrirang; Radeka, Veljko; Vaska, Paul; Pratte, Jean-Francois; Volkow, Nora

2006-10-24

A method of serially transferring annihilation information in a compact positron emission tomography (PET) scanner includes generating a time signal for an event, generating an address signal representing a detecting channel, generating a detector channel signal including the time and address signals, and generating a composite signal including the channel signal and similarly generated signals. The composite signal includes events from detectors in a block and is serially output. An apparatus that serially transfers annihilation information from a block includes time signal generators for detectors in a block and an address and channel signal generator. The PET scanner includes a ring tomograph that mounts onto a portion of an animal, which includes opposing block pairs. Each of the blocks in a block pair includes a scintillator layer, detection array, front-end array, and a serial encoder. The serial encoder includes time signal generators and an address signal and channel signal generator.

Magnetic induction tomography of objects for security applications

NASA Astrophysics Data System (ADS)

Ward, Rob; Joseph, Max; Langley, Abbi; Taylor, Stuart; Watson, Joe C.

2017-10-01

A coil array imaging system has been further developed from previous investigations, focusing on designing its application for fast screening of small bags or parcels, with a view to the production of a compact instrument for security applications. In addition to reducing image acquisition times, work was directed toward exploring potential cost effective manufacturing routes. Based on magnetic induction tomography and eddy-current principles, the instrument captured images of conductive targets using a lock-in amplifier, individually multiplexing signals between a primary driver coil and a 20 by 21 imaging array of secondary passive coils constructed using a reproducible multiple tile design. The design was based on additive manufacturing techniques and provided 2 orthogonal imaging planes with an ability to reconstruct images in less than 10 seconds. An assessment of one of the imaging planes is presented. This technique potentially provides a cost effective threat evaluation technique that may compliment conventional radiographic approaches.

Full-field fan-beam x-ray fluorescence computed tomography system design with linear-array detectors and pinhole collimation: a rapid Monte Carlo study

NASA Astrophysics Data System (ADS)

Zhang, Siyuan; Li, Liang; Li, Ruizhe; Chen, Zhiqiang

2017-11-01

We present the design concept and initial simulations for a polychromatic full-field fan-beam x-ray fluorescence computed tomography (XFCT) device with pinhole collimators and linear-array photon counting detectors. The phantom is irradiated by a fan-beam polychromatic x-ray source filtered by copper. Fluorescent photons are stimulated and then collected by two linear-array photon counting detectors with pinhole collimators. The Compton scatter correction and the attenuation correction are applied in the data processing, and the maximum-likelihood expectation maximization algorithm is applied for the image reconstruction of XFCT. The physical modeling of the XFCT imaging system was described, and a set of rapid Monte Carlo simulations was carried out to examine the feasibility and sensitivity of the XFCT system. Different concentrations of gadolinium (Gd) and gold (Au) solutions were used as contrast agents in simulations. Results show that 0.04% of Gd and 0.065% of Au can be well reconstructed with the full scan time set at 6 min. Compared with using the XFCT system with a pencil-beam source or a single-pixel detector, using a full-field fan-beam XFCT device with linear-array detectors results in significant scanning time reduction and may satisfy requirements of rapid imaging, such as in vivo imaging experiments.

A micromachined silicon parallel acoustic delay line (PADL) array for real-time photoacoustic tomography (PAT)

NASA Astrophysics Data System (ADS)

Cho, Young Y.; Chang, Cheng-Chung; Wang, Lihong V.; Zou, Jun

2015-03-01

To achieve real-time photoacoustic tomography (PAT), massive transducer arrays and data acquisition (DAQ) electronics are needed to receive the PA signals simultaneously, which results in complex and high-cost ultrasound receiver systems. To address this issue, we have developed a new PA data acquisition approach using acoustic time delay. Optical fibers were used as parallel acoustic delay lines (PADLs) to create different time delays in multiple channels of PA signals. This makes the PA signals reach a single-element transducer at different times. As a result, they can be properly received by single-channel DAQ electronics. However, due to their small diameter and fragility, using optical fiber as acoustic delay lines poses a number of challenges in the design, construction and packaging of the PADLs, thereby limiting their performances and use in real imaging applications. In this paper, we report the development of new silicon PADLs, which are directly made from silicon wafers using advanced micromachining technologies. The silicon PADLs have very low acoustic attenuation and distortion. A linear array of 16 silicon PADLs were assembled into a handheld package with one common input port and one common output port. To demonstrate its real-time PAT capability, the silicon PADL array (with its output port interfaced with a single-element transducer) was used to receive 16 channels of PA signals simultaneously from a tissue-mimicking optical phantom sample. The reconstructed PA image matches well with the imaging target. Therefore, the silicon PADL array can provide a 16× reduction in the ultrasound DAQ channels for real-time PAT.

SU-F-T-270: A Technique for Modeling a Diode Array Into the TPS for Lung SBRT Patient Specific QA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Curley, C; Leventouri, T; Ouhib, Z

2016-06-15

Purpose: To accurately match the treatment planning system (TPS) with the measurement environment, where quality assurance (QA) devices are used to collect data, for lung Stereotactic Body Radiation Therapy (SBRT) patient specific QA. Incorporation of heterogeneities is also studied. Methods: Dual energy computerized tomography (DECT) and single energy computerized tomography (SECT) were used to model phantoms incorporating a 2-D diode array into the TPS. A water-equivalent and a heterogeneous phantom (simulating the thoracic region of a patient) were studied. Monte Carlo and pencil beam planar dose distributions were compared to measured distributions. Composite and individual fields were analyzed for normallymore » incident and planned gantry angle deliveries. γ- analysis was used with criteria 3% 3mm, 2% 2mm, and 1% 1mm. Results: The Monte Carlo calculations for the DECT resulted in improved agreements with the diode array for 46.4% of the fields at 3% 3mm, 85.7% at 2% 2mm, and 92.9% at 1% 1mm.For the SECT, the Monte Carlo calculations gave no agreement for the same γ-analysis criteria. Pencil beam calculations resulted in lower agreements with the diode array in the TPS. The DECT showed improvements for 14.3% of the fields at 3% 3mm and 2% 2mm, and 28.6% at 1% 1mm.In SECT comparisons, 7.1% of the fields at 3% 3mm, 10.7% at 2% 2mm, and 17.9% at 1% 1mm showed improved agreements with the diode array. Conclusion: This study demonstrates that modeling the diode array in the TPS is viable using DECT with Monte Carlo for patient specific lung SBRT QA. As recommended by task groups (e.g. TG 65, TG 101, TG 244) of the American Association of Physicists in Medicine (AAPM), pencil beam algorithms should be avoided in the presence of heterogeneous materials, including a diode array.« less

State Waste Discharge Permit Application: Electric resistance tomography testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-04-01

This permit application documentation is for a State Waste Discharge Permit issued in accordance with requirements of Washington Administrative Code 173-216. The activity being permitted is a technology test using electrical resistance tomography. The electrical resistance tomography technology was developed at Lawrence Livermore National Laboratory and has been used at other waste sites to track underground contamination plumes. The electrical resistance tomography technology measures soil electrical resistance between two electrodes. If a fluid contaminated with electrolytes is introduced into the soil, the soil resistance is expected to drop. By using an array of measurement electrodes in several boreholes, the arealmore » extent of contamination can be estimated. At the Hanford Site, the purpose of the testing is to determine if the electrical resistance tomography technology can be used in the vicinity of large underground metal tanks without the metal tank interfering with the test. It is anticipated that the electrical resistance tomography technology will provide a method for accurately detecting leaks from the bottom of underground tanks, such as the Hanford Site single-shell tanks.« less

Tomography with energy dispersive diffraction

NASA Astrophysics Data System (ADS)

Stock, S. R.; Okasinski, J. S.; Woods, R.; Baldwin, J.; Madden, T.; Quaranta, O.; Rumaiz, A.; Kuczewski, T.; Mead, J.; Krings, T.; Siddons, P.; Miceli, A.; Almer, J. D.

2017-09-01

X-ray diffraction can be used as the signal for tomographic reconstruction and provides a cross-sectional map of the crystallographic phases and related quantities. Diffraction tomography has been developed over the last decade using monochromatic x-radiation and an area detector. This paper reports tomographic reconstruction with polychromatic radiation and an energy sensitive detector array. The energy dispersive diffraction (EDD) geometry, the instrumentation and the reconstruction process are described and related to the expected resolution. Results of EDD tomography are presented for two samples containing hydroxyapatite (hAp). The first is a 3D-printed sample with an elliptical crosssection and contains synthetic hAp. The second is a human second metacarpal bone from the Roman-era cemetery at Ancaster, UK and contains bio-hAp which may have been altered by diagenesis. Reconstructions with different diffraction peaks are compared. Prospects for future EDD tomography are also discussed.

Finite element Compton tomography

NASA Astrophysics Data System (ADS)

Jannson, Tomasz; Amouzou, Pauline; Menon, Naresh; Gertsenshteyn, Michael

2007-09-01

In this paper a new approach to 3D Compton imaging is presented, based on a kind of finite element (FE) analysis. A window for X-ray incoherent scattering (or Compton scattering) attenuation coefficients is identified for breast cancer diagnosis, for hard X-ray photon energy of 100-300 keV. The point-by-point power/energy budget is computed, based on a 2D array of X-ray pencil beams, scanned vertically. The acceptable medical doses are also computed. The proposed finite element tomography (FET) can be an alternative to X-ray mammography, tomography, and tomosynthesis. In experiments, 100 keV (on average) X-ray photons are applied, and a new type of pencil beam collimation, based on a Lobster-Eye Lens (LEL), is proposed.

Application of wavefield compressive sensing in surface wave tomography

NASA Astrophysics Data System (ADS)

Zhan, Zhongwen; Li, Qingyang; Huang, Jianping

2018-06-01

Dense arrays allow sampling of seismic wavefield without significant aliasing, and surface wave tomography has benefitted from exploiting wavefield coherence among neighbouring stations. However, explicit or implicit assumptions about wavefield, irregular station spacing and noise still limit the applicability and resolution of current surface wave methods. Here, we propose to apply the theory of compressive sensing (CS) to seek a sparse representation of the surface wavefield using a plane-wave basis. Then we reconstruct the continuous surface wavefield on a dense regular grid before applying any tomographic methods. Synthetic tests demonstrate that wavefield CS improves robustness and resolution of Helmholtz tomography and wavefield gradiometry, especially when traditional approaches have difficulties due to sub-Nyquist sampling or complexities in wavefield.

Proposal of one-shot-type spectroscopic-tomography for non-invasive medical-measurement

NASA Astrophysics Data System (ADS)

Sato, Shun; Fujiwara, Masaru; Abeygunawardhana, Pradeep K. W.; Suzuki, Satoru; Nishiyama, Akira; Ishimaru, Ichiro

2013-06-01

The one-shot-type spectroscopic-tomography is proposed to develop the medical-patient-condition monitoring systems. The optical-setup is configured with the relative-inclined phase-shifter for improving the time resolution and the phase-shift array for improving visibility. We obtained the line-spectroscopic imaging and could recognize the Hg bright-line-spectrum that is a component of the light-source. The realization of the optical stethoscope for early diagnosis of cancer can be expected by obtaining the 2-dimensional spectroscopic distribution with rotating interferometer.

Color camera computed tomography imaging spectrometer for improved spatial-spectral image accuracy

NASA Technical Reports Server (NTRS)

Wilson, Daniel W. (Inventor); Bearman, Gregory H. (Inventor); Johnson, William R. (Inventor)

2011-01-01

Computed tomography imaging spectrometers ("CTIS"s) having color focal plane array detectors are provided. The color FPA detector may comprise a digital color camera including a digital image sensor, such as a Foveon X3.RTM. digital image sensor or a Bayer color filter mosaic. In another embodiment, the CTIS includes a pattern imposed either directly on the object scene being imaged or at the field stop aperture. The use of a color FPA detector and the pattern improves the accuracy of the captured spatial and spectral information.

An Optimal Parameterization Framework for Infrasonic Tomography of the Stratospheric Winds Using Non-Local Sources

DOE PAGES

Blom, Philip Stephen; Marcillo, Omar Eduardo

2016-12-05

A method is developed to apply acoustic tomography methods to a localized network of infrasound arrays with intention of monitoring the atmosphere state in the region around the network using non-local sources without requiring knowledge of the precise source location or non-local atmosphere state. Closely spaced arrays provide a means to estimate phase velocities of signals that can provide limiting bounds on certain characteristics of the atmosphere. Larger spacing between such clusters provide a means to estimate celerity from propagation times along multiple unique stratospherically or thermospherically ducted propagation paths and compute more precise estimates of the atmosphere state. Inmore » order to avoid the commonly encountered complex, multimodal distributions for parametric atmosphere descriptions and to maximize the computational efficiency of the method, an optimal parametrization framework is constructed. This framework identifies the ideal combination of parameters for tomography studies in specific regions of the atmosphere and statistical model selection analysis shows that high quality corrections to the middle atmosphere winds can be obtained using as few as three parameters. Lastly, comparison of the resulting estimates for synthetic data sets shows qualitative agreement between the middle atmosphere winds and those estimated from infrasonic traveltime observations.« less

SUPER-RESOLUTION ULTRASOUND TOMOGRAPHY: A PRELIMINARY STUDY WITH A RING ARRAY

DOE Office of Scientific and Technical Information (OSTI.GOV)

HUANG, LIANJIE; SIMONETTI, FRANCESCO; DURIC, NEBOJSA

2007-01-18

Ultrasound tomography attempts to retrieve the structure of an objective by exploiting the interaction of acoustic waves with the object. A fundamental limit of ultrasound tomography is that features cannot be resolved if they are spaced less than {lambda}/2 apart, where {lambda} is wavelength of the probing wave, regardless of the degree of accuracy of the measurements. Therefore, since the attenuation of the probing wave with propagation distance increases as {lambda} decreases, resolution has to be traded against imaging depth. Recently, it has been shown that the {lambda}/2 limit is a consequence of the Born approximation (implicit in the imagingmore » algorithms currently employed) which neglects the distortion of the probing wavefield as it travels through the medium to be imaged. On the other hand, such a distortion, which is due to the multiple scattering phenomenon, can encode unlimited resolution in the radiating component of the scattered field. Previously, a resolution better than {lambda}/3 has been reported in these proceedings [F. Simonetti, pp. 126 (2006)] in the case of elastic wave probing. In this paper, they demonstrate experimentally a resolution better than {lambda}/4 for objects immersed in a water bth probed by means of a ring array which excites and detects pressure waves in a full view configuration.« less

Multiple single-element transducer photoacoustic computed tomography system

NASA Astrophysics Data System (ADS)

Kalva, Sandeep Kumar; Hui, Zhe Zhi; Pramanik, Manojit

2018-02-01

Light absorption by the chromophores (hemoglobin, melanin, water etc.) present in any biological tissue results in local temperature rise. This rise in temperature results in generation of pressure waves due to the thermoelastic expansion of the tissue. In a circular scanning photoacoustic computed tomography (PACT) system, these pressure waves can be detected using a single-element ultrasound transducer (SUST) (while rotating in full 360° around the sample) or using a circular array transducer. SUST takes several minutes to acquire the PA data around the sample whereas the circular array transducer takes only a fraction of seconds. Hence, for real time imaging circular array transducers are preferred. However, these circular array transducers are custom made, expensive and not easily available in the market whereas SUSTs are cheap and readily available in the market. Using SUST for PACT systems is still cost effective. In order to reduce the scanning time to few seconds instead of using single SUST (rotating 360° ), multiple SUSTs can be used at the same time to acquire the PA data. This will reduce the scanning time by two-fold in case of two SUSTs (rotating 180° ) or by four-fold and eight-fold in case of four SUSTs (rotating 90° ) and eight SUSTs (rotating 45° ) respectively. Here we show that with multiple SUSTs, similar PA images (numerical and experimental phantom data) can be obtained as that of PA images obtained using single SUST.

Using computed tomography and 3D printing to construct custom prosthetics attachments and devices.

PubMed

Liacouras, Peter C; Sahajwalla, Divya; Beachler, Mark D; Sleeman, Todd; Ho, Vincent B; Lichtenberger, John P

2017-01-01

The prosthetic devices the military uses to restore function and mobility to our wounded warriors are highly advanced, and in many instances not publically available. There is considerable research aimed at this population of young patients who are extremely active and desire to take part in numerous complex activities. While prosthetists design and manufacture numerous devices with standard materials and limb assemblies, patients often require individualized prosthetic design and/or modifications to enable them to participate fully in complex activities. Prosthetists and engineers perform research and implement digitally designs in collaboration to generate equipment for their patient's rehabilitation needs. 3D printing allows for these devices to be manufactured from an array of materials ranging from plastic to titanium alloy. Many designs require form fitting to a prosthetic socket or a complex surface geometry. Specialty items can be scanned using computed tomography and digitally reconstructed to produce a virtual 3D model the engineer can use to design the necessary features of the desired prosthetic, device, or attachment. Completed devices are tested for fit and function. Numerous custom prostheses and attachments have been successfully translated from the research domain to clinical reality, in particular, those that feature the use of computed tomography (CT) reconstructions. The purpose of this project is to describe the research pathways to implementation for the following clinical designs: sets of bilateral hockey skates; custom weightlifting prosthetic hands; and a wine glass holder. This article will demonstrate how to incorporate CT imaging and 3D printing in the design and manufacturing process of custom attachments and assistive technology devices. Even though some of these prosthesis attachments may be relatively simple in design to an engineer, they have an enormous impact on the lives of our wounded warriors.

Transcutaneous Raman spectroscopy for assessing progress of bone-graft incorporation in bone reconstruction and repair

NASA Astrophysics Data System (ADS)

Okagbare, Paul I.; Esmonde-White, Francis W. L.; Goldstein, Steven A.; Morris, Michael D.

2011-03-01

Allografts and other bone-grafts are frequently used for a variety of reconstructive approaches in orthopaedic surgery. However, successful allograft incorporation remains uncertain. Consequently, there is significant need for methods to monitor the fate of these constructs. Only few noninvasive methods can fully assess the progress of graft incorporation and to provide information on the metabolic status of the graft, such as the mineral and matrix composition of the regenerated-tissue that may provide early indications of graft success or failure. For example, Computed-tomography and MRI provide information on the morphology of the graft/host interface. Limited information is also available from DXA. To address this challenge, we present here the implementation of a noninvasive Raman spectroscopy technique for in-vivo assessment of allograft incorporation in animal-model. In an animal use committee approved osseointegration experiment, a 3mm defect is created in rat's tibia. The defect is reconstructed using auto or allograft and Raman spectra are collected at several time-points during healing using an array of optical-fibers in contact with the skin of the rat over the tibia while the rat is anaesthetized. The array allows excitation and collection of Raman spectra through the skin at various positions around the tibia. Raman parameters such as mineral/matrix, carbonate/phosphate and cross-linking are recovered and monitored. The system is calibrated against locally-constructed phantoms that mimic the morphology, optics and spectroscopy of the rat. This new technology provides a non-invasive method for in-vivo assessment of bone-graft incorporation in animal-models and can be adapted for similar study in human subjects.

Preclinical positron emission tomography scanner based on a monolithic annulus of scintillator: initial design study

PubMed Central

Stolin, Alexander V.; Martone, Peter F.; Jaliparthi, Gangadhar; Raylman, Raymond R.

2017-01-01

Abstract. Positron emission tomography (PET) scanners designed for imaging of small animals have transformed translational research by reducing the necessity to invasively monitor physiology and disease progression. Virtually all of these scanners are based on the use of pixelated detector modules arranged in rings. This design, while generally successful, has some limitations. Specifically, use of discrete detector modules to construct PET scanners reduces detection sensitivity and can introduce artifacts in reconstructed images, requiring the use of correction methods. To address these challenges, and facilitate measurement of photon depth-of-interaction in the detector, we investigated a small animal PET scanner (called AnnPET) based on a monolithic annulus of scintillator. The scanner was created by placing 12 flat facets around the outer surface of the scintillator to accommodate placement of silicon photomultiplier arrays. Its performance characteristics were explored using Monte Carlo simulations and sections of the NEMA NU4-2008 protocol. Results from this study revealed that AnnPET’s reconstructed spatial resolution is predicted to be ∼1  mm full width at half maximum in the radial, tangential, and axial directions. Peak detection sensitivity is predicted to be 10.1%. Images of simulated phantoms (mini-hot rod and mouse whole body) yielded promising results, indicating the potential of this system for enhancing PET imaging of small animals. PMID:28097210

Fast photoacoustic imaging system based on 320-element linear transducer array.

PubMed

Yin, Bangzheng; Xing, Da; Wang, Yi; Zeng, Yaguang; Tan, Yi; Chen, Qun

2004-04-07

A fast photoacoustic (PA) imaging system, based on a 320-transducer linear array, was developed and tested on a tissue phantom. To reconstruct a test tomographic image, 64 time-domain PA signals were acquired from a tissue phantom with embedded light-absorption targets. A signal acquisition was accomplished by utilizing 11 phase-controlled sub-arrays, each consisting of four transducers. The results show that the system can rapidly map the optical absorption of a tissue phantom and effectively detect the embedded light-absorbing target. By utilizing the multi-element linear transducer array and phase-controlled imaging algorithm, we thus can acquire PA tomography more efficiently, compared to other existing technology and algorithms. The methodology and equipment thus provide a rapid and reliable approach to PA imaging that may have potential applications in noninvasive imaging and clinic diagnosis.

On-Line Corrosion Monitoring of Plate Structures Based on Guided Wave Tomography Using Piezoelectric Sensors.

PubMed

Rao, Jing; Ratassepp, Madis; Lisevych, Danylo; Hamzah Caffoor, Mahadhir; Fan, Zheng

2017-12-12

Corrosion is a major safety and economic concern to various industries. In this paper, a novel ultrasonic guided wave tomography (GWT) system based on self-designed piezoelectric sensors is presented for on-line corrosion monitoring of large plate-like structures. Accurate thickness reconstruction of corrosion damages is achieved by using the dispersive regimes of selected guided waves and a reconstruction algorithm based on full waveform inversion (FWI). The system makes use of an array of miniaturised piezoelectric transducers that are capable of exciting and receiving highly dispersive A0 Lamb wave mode at low frequencies. The scattering from transducer array has been found to have a small effect on the thickness reconstruction. The efficiency and the accuracy of the new system have been demonstrated through continuous forced corrosion experiments. The FWI reconstructed thicknesses show good agreement with analytical predictions obtained by Faraday's law and laser measurements, and more importantly, the thickness images closely resemble the actual corrosion sites.

Electrical resistivity tomography to quantify in situ liquid content in a full-scale dry anaerobic digestion reactor.

PubMed

André, L; Lamy, E; Lutz, P; Pernier, M; Lespinard, O; Pauss, A; Ribeiro, T

2016-02-01

The electrical resistivity tomography (ERT) method is a non-intrusive method widely used in landfills to detect and locate liquid content. An experimental set-up was performed on a dry batch anaerobic digestion reactor to investigate liquid repartition in process and to map spatial distribution of inoculum. Two array electrodes were used: pole-dipole and gradient arrays. A technical adaptation of ERT method was necessary. Measured resistivity data were inverted and modeled by RES2DINV software to get resistivity sections. Continuous calibration along resistivity section was necessary to understand data involving sampling and physicochemical analysis. Samples were analyzed performing both biochemical methane potential and fiber quantification. Correlations were established between the protocol of reactor preparation, resistivity values, liquid content, methane potential and fiber content representing liquid repartition, high methane potential zones and degradations zones. ERT method showed a strong relevance to monitor and to optimize the dry batch anaerobic digestion process. Copyright © 2015 Elsevier Ltd. All rights reserved.

In vivo rat deep brain imaging using photoacoustic computed tomography (Conference Presentation)

NASA Astrophysics Data System (ADS)

Lin, Li; Li, Lei; Zhu, Liren; Hu, Peng; Wang, Lihong V.

2017-03-01

The brain has been likened to a great stretch of unknown territory consisting of a number of unexplored continents. Small animal brain imaging plays an important role charting that territory. By using 1064 nm illumination from the side, we imaged the full coronal depth of rat brains in vivo. The experiment was performed using a real-time full-ring-array photoacoustic computed tomography (PACT) imaging system, which achieved an imaging depth of 11 mm and a 100 μm radial resolution. Because of the fast imaging speed of the full-ring-array PACT system, no animal motion artifact was induced. The frame rate of the system was limited by the laser repetition rate (50 Hz). In addition to anatomical imaging of the blood vessels in the brain, we continuously monitored correlations between the two brain hemispheres in one of the coronal planes. The resting states in the coronal plane were measured before and after stroke ligation surgery at a neck artery.

Highly precise acoustic calibration method of ring-shaped ultrasound transducer array for plane-wave-based ultrasound tomography

NASA Astrophysics Data System (ADS)

Terada, Takahide; Yamanaka, Kazuhiro; Suzuki, Atsuro; Tsubota, Yushi; Wu, Wenjing; Kawabata, Ken-ichi

2017-07-01

Ultrasound computed tomography (USCT) is promising for a non-invasive, painless, operator-independent and quantitative system for breast-cancer screening. Assembly error, production tolerance, and aging-degradation variations of the hardwire components, particularly of plane-wave-based USCT systems, may hamper cost effectiveness, precise imaging, and robust operation. The plane wave is transmitted from a ring-shaped transducer array for receiving the signal at a high signal-to-noise-ratio and fast aperture synthesis. There are four signal-delay components: response delays in the transmitters and receivers and propagation delays depending on the positions of the transducer elements and their directivity. We developed a highly precise calibration method for calibrating these delay components and evaluated it with our prototype plane-wave-based USCT system. Our calibration method was found to be effective in reducing delay errors. Gaps and curves were eliminated from the plane wave, and echo images of wires were sharpened in the entire imaging area.

Recent Progress on the Stretched Lens Array (SLA)

NASA Technical Reports Server (NTRS)

O'Neill, Markl; McDanal, A. J.; Piszczor, Michael; George, Patrick; Eskenazi, Michael; Botke, Matthew; Edwards, David; Hoppe, David; Brandhorst, Henry

2005-01-01

At the last Space Photovoltaic Research and Technology Conference, SPRAT XVII, held during the fateful week of 9/11/01, our team presented a paper on the early developments related to the new Stretched Lens Array (SLA), including its evolution from the successful SCARLET array on the NASA/JPL Deep Space 1 spacecraft. Within the past two years, the SLA team has made significant progress in the SLA technology, including the successful fabrication and testing of a complete four-panel prototype solar array wing (Fig. 1). The prototype wing verified the mechanical and structural design of the rigid-panel SLA approach, including multiple successful demonstrations of automatic wing deployment. One panel in the prototype wing included four fully functional photovoltaic receivers, employing triple-junction solar cells.

Arrival Time Tracking of Partially Resolved Acoustic Rays with Application to Ocean Acoustic Tomography

DTIC Science & Technology

1991-03-01

ocean acoustic tomography. A straightforward method of arrival time estimation, based on locating the maximum value of an interpolated arrival, was...used with limited success for analysis of data from the December 1988 Monterey Bay Tomography Experiment. Close examination of the data revealed multiple...estimation of arrival times along an ocean acoustic ray path is an important component of ocean acoustic tomography. A straightforward method of arrival time

Improvement of electrical resistivity tomography for leachate injection monitoring.

PubMed

Clément, R; Descloitres, M; Günther, T; Oxarango, L; Morra, C; Laurent, J-P; Gourc, J-P

2010-03-01

Leachate recirculation is a key process in the scope of operating municipal waste landfills as bioreactors, which aims to increase the moisture content to optimize the biodegradation in landfills. Given that liquid flows exhibit a complex behaviour in very heterogeneous porous media, in situ monitoring methods are required. Surface time-lapse electrical resistivity tomography (ERT) is usually proposed. Using numerical modelling with typical 2D and 3D injection plume patterns and 2D and 3D inversion codes, we show that wrong changes of resistivity can be calculated at depth if standard parameters are used for time-lapse ERT inversion. Major artefacts typically exhibit significant increases of resistivity (more than +30%) which can be misinterpreted as gas migration within the waste. In order to eliminate these artefacts, we tested an advanced time-lapse ERT procedure that includes (i) two advanced inversion tools and (ii) two alternative array geometries. The first advanced tool uses invariant regions in the model. The second advanced tool uses an inversion with a "minimum length" constraint. The alternative arrays focus on (i) a pole-dipole array (2D case), and (ii) a star array (3D case). The results show that these two advanced inversion tools and the two alternative arrays remove almost completely the artefacts within +/-5% both for 2D and 3D situations. As a field application, time-lapse ERT is applied using the star array during a 3D leachate injection in a non-hazardous municipal waste landfill. To evaluate the robustness of the two advanced tools, a synthetic model including both true decrease and increase of resistivity is built. The advanced time-lapse ERT procedure eliminates unwanted artefacts, while keeping a satisfactory image of true resistivity variations. This study demonstrates that significant and robust improvements can be obtained for time-lapse ERT monitoring of leachate recirculation in waste landfills. Copyright 2009 Elsevier Ltd. All rights reserved.

Improvement of electrical resistivity tomography for leachate injection monitoring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clement, R., E-mail: remi.clement@hmg.inpg.f; Descloitres, M.; Guenther, T., E-mail: Thomas.Guenther@liag-hannover.d

2010-03-15

Leachate recirculation is a key process in the scope of operating municipal waste landfills as bioreactors, which aims to increase the moisture content to optimize the biodegradation in landfills. Given that liquid flows exhibit a complex behaviour in very heterogeneous porous media, in situ monitoring methods are required. Surface time-lapse electrical resistivity tomography (ERT) is usually proposed. Using numerical modelling with typical 2D and 3D injection plume patterns and 2D and 3D inversion codes, we show that wrong changes of resistivity can be calculated at depth if standard parameters are used for time-lapse ERT inversion. Major artefacts typically exhibit significantmore » increases of resistivity (more than +30%) which can be misinterpreted as gas migration within the waste. In order to eliminate these artefacts, we tested an advanced time-lapse ERT procedure that includes (i) two advanced inversion tools and (ii) two alternative array geometries. The first advanced tool uses invariant regions in the model. The second advanced tool uses an inversion with a 'minimum length' constraint. The alternative arrays focus on (i) a pole-dipole array (2D case), and (ii) a star array (3D case). The results show that these two advanced inversion tools and the two alternative arrays remove almost completely the artefacts within +/-5% both for 2D and 3D situations. As a field application, time-lapse ERT is applied using the star array during a 3D leachate injection in a non-hazardous municipal waste landfill. To evaluate the robustness of the two advanced tools, a synthetic model including both true decrease and increase of resistivity is built. The advanced time-lapse ERT procedure eliminates unwanted artefacts, while keeping a satisfactory image of true resistivity variations. This study demonstrates that significant and robust improvements can be obtained for time-lapse ERT monitoring of leachate recirculation in waste landfills.« less

Photoacoustic Imaging of Animals with an Annular Transducer Array

NASA Astrophysics Data System (ADS)

Yang, Di-Wu; Zhou, Zhi-Bin; Zeng, Lv-Ming; Zhou, Xin; Chen, Xing-Hui

2014-07-01

A photoacoustic system with an annular transducer array is presented for rapid, high-resolution photoacoustic tomography of animals. An eight-channel data acquisition system is applied to capture the photoacoustic signals by using multiplexing and the total time of data acquisition and transferring is within 3 s. A limited-view filtered back projection algorithm is used to reconstruct the photoacoustic images. Experiments are performed on a mouse head and a rabbit head and clear photoacoustic images are obtained. The experimental results demonstrate that this imaging system holds the potential for imaging the human brain.

Diffraction mode terahertz tomography

DOEpatents

Ferguson, Bradley; Wang, Shaohong; Zhang, Xi-Cheng

2006-10-31

A method of obtaining a series of images of a three-dimensional object. The method includes the steps of transmitting pulsed terahertz (THz) radiation through the entire object from a plurality of angles, optically detecting changes in the transmitted THz radiation using pulsed laser radiation, and constructing a plurality of imaged slices of the three-dimensional object using the detected changes in the transmitted THz radiation. The THz radiation is transmitted through the object as a two-dimensional array of parallel rays. The optical detection is an array of detectors such as a CCD sensor.

Body Wave and Ambient Noise Tomography of Makushin Volcano, Alaska

NASA Astrophysics Data System (ADS)

Lanza, F.; Thurber, C. H.; Syracuse, E. M.; Ghosh, A.; LI, B.; Power, J. A.

2017-12-01

Located in the eastern portion of the Alaska-Aleutian subduction zone, Makushin Volcano is among the most active volcanoes in the United States and has been classified as high threat based on eruptive history and proximity to the City of Unalaska and international air routes. In 2015, five individual seismic stations and three mini seismic arrays of 15 stations each were deployed on Unalaska island to supplement the Alaska Volcano Observatory (AVO) permanent seismic network. This temporary array was operational for one year. Taking advantage of the increased azimuthal coverage and the array's increased earthquake detection capability, we developed body-wave Vp and Vp/Vs seismic images of the velocity structure beneath the volcano. Body-wave tomography results show a complex structure with the upper 5 km of the crust dominated by both positive and negative Vp anomalies. The shallow high-Vp features possibly delineate remnant magma pathways or conduits. Low-Vp regions are found east of the caldera at approximately 6-9 km depth. This is in agreement with previous tomographic work and geodetic models, obtained using InSAR data, which had identified this region as a possible long-term source of magma. We also observe a high Vp/Vs feature extending between 7 and 12 km depth below the caldera, possibly indicating partial melting, although the resolution is diminished at these depths. The distributed stations allow us to further complement body-wave tomography with ambient noise imaging and to obtain higher quality of Vs images. Our data processing includes single station data preparation and station-pair cross-correlation steps (Bensen et al., 2007), and the use of the phase weighted stacking method (Schimmel and Gallart, 2007) to improve the signal-to-noise ratio of the cross-correlations. We will show surface-wave dispersion curves, group velocity maps, and ultimately a 3D Vs image. By performing both body wave and ambient noise tomography, we provide a high-resolution tomographic image of Makushin Volcano as well as better-constrained earthquake locations, thus enhancing AVO's monitoring and forecasting efforts.

Electromagnetic induction imaging with a radio-frequency atomic magnetometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deans, Cameron; Marmugi, Luca, E-mail: l.marmugi@ucl.ac.uk; Hussain, Sarah

2016-03-07

We report on a compact, tunable, and scalable to large arrays imaging device, based on a radio-frequency optically pumped atomic magnetometer operating in magnetic induction tomography modality. Imaging of conductive objects is performed at room temperature, in an unshielded environment and without background subtraction. Conductivity maps of target objects exhibit not only excellent performance in terms of shape reconstruction but also demonstrate detection of sub-millimetric cracks and penetration of conductive barriers. The results presented here demonstrate the potential of a future generation of imaging instruments, which combine magnetic induction tomography and the unmatched performance of atomic magnetometers.

A novel fast-neutron tomography system based on a plastic scintillator array and a compact D-D neutron generator.

PubMed

Adams, Robert; Zboray, Robert; Prasser, Horst-Michael

2016-01-01

Very few experimental imaging studies using a compact neutron generator have been published, and to the knowledge of the authors none have included tomography results using multiple projection angles. Radiography results with a neutron generator, scintillator screen, and camera can be seen in Bogolubov et al. (2005), Cremer et al. (2012), and Li et al. (2014). Comparable results with a position-sensitive photomultiplier tube can be seen in Popov et al. (2011). One study using an array of individual fast neutron detectors in the context of cargo scanning for security purposes is detailed in Eberhardt et al. (2005). In that case, however, the emphasis was on very large objects with a resolution on the order of 1cm, whereas this study focuses on less massive objects and a finer spatial resolution. In Andersson et al. (2014) three fast neutron counters and a D-T generator were used to perform attenuation measurements of test phantoms. Based on the axisymmetry of the test phantoms, the single-projection information was used to calculate radial attenuation distributions of the object, which was compared with the known geometry. In this paper a fast-neutron tomography system based on an array of individual detectors and a purpose-designed compact D-D neutron generator is presented. Each of the 88 detectors consists of a plastic scintillator read out by two Silicon photomultipliers and a dedicated pulse-processing board. Data acquisition for all channels was handled by four single-board microcontrollers. Details of the individual detector design and testing are elaborated upon. Using the complete array, several fast-neutron images of test phantoms were reconstructed, one of which was compared with results using a Co-60 gamma source. The system was shown to be capable of 2mm resolution, with exposure times on the order of several hours per reconstructed tomogram. Details about these measurements and the analysis of the reconstructed images are given, along with a discussion of the capabilities of the system and its outlook. Copyright © 2015 Elsevier Ltd. All rights reserved.

Sensitivity encoded silicon photomultiplier--a new sensor for high-resolution PET-MRI.

PubMed

Schulz, Volkmar; Berker, Yannick; Berneking, Arne; Omidvari, Negar; Kiessling, Fabian; Gola, Alberto; Piemonte, Claudio

2013-07-21

Detectors for simultaneous positron emission tomography and magnetic resonance imaging in particular with sub-mm spatial resolution are commonly composed of scintillator crystal arrays, readout via arrays of solid state sensors, such as avalanche photo diodes (APDs) or silicon photomultipliers (SiPMs). Usually a light guide between the crystals and the sensor is used to enable the identification of crystals which are smaller than the sensor elements. However, this complicates crystal identification at the gaps and edges of the sensor arrays. A solution is to use as many sensors as crystals with a direct coupling, which unfortunately increases the complexity and power consumption of the readout electronics. Since 1997, position-sensitive APDs have been successfully used to identify sub-mm crystals. Unfortunately, these devices show a limitation in their time resolution and a degradation of spatial resolution when placed in higher magnetic fields. To overcome these limitations, this paper presents a new sensor concept that extends conventional SiPMs by adding position information via the spatial encoding of the channel sensitivity. The concept allows a direct coupling of high-resolution crystal arrays to the sensor with a reduced amount of readout channels. The theory of sensitivity encoding is detailed and linked to compressed sensing to compute unique sparse solutions. Two devices have been designed using one- and two-dimensional linear sensitivity encoding with eight and four readout channels, respectively. Flood histograms of both devices show the capability to precisely identify all 4 × 4 LYSO crystals with dimensions of 0.93 × 0.93 × 10 mm(3). For these crystals, the energy and time resolution (MV ± SD) of the devices with one (two)-dimensional encoding have been measured to be 12.3 · (1 ± 0.047)% (13.7 · (1 ± 0.047)%) around 511 keV with a paired coincidence time resolution (full width at half maximum) of 462 · (1 ± 0.054) ps (452 · (1 ± 0.078) ps).

Sensitivity encoded silicon photomultiplier—a new sensor for high-resolution PET-MRI

NASA Astrophysics Data System (ADS)

Schulz, Volkmar; Berker, Yannick; Berneking, Arne; Omidvari, Negar; Kiessling, Fabian; Gola, Alberto; Piemonte, Claudio

2013-07-01

Detectors for simultaneous positron emission tomography and magnetic resonance imaging in particular with sub-mm spatial resolution are commonly composed of scintillator crystal arrays, readout via arrays of solid state sensors, such as avalanche photo diodes (APDs) or silicon photomultipliers (SiPMs). Usually a light guide between the crystals and the sensor is used to enable the identification of crystals which are smaller than the sensor elements. However, this complicates crystal identification at the gaps and edges of the sensor arrays. A solution is to use as many sensors as crystals with a direct coupling, which unfortunately increases the complexity and power consumption of the readout electronics. Since 1997, position-sensitive APDs have been successfully used to identify sub-mm crystals. Unfortunately, these devices show a limitation in their time resolution and a degradation of spatial resolution when placed in higher magnetic fields. To overcome these limitations, this paper presents a new sensor concept that extends conventional SiPMs by adding position information via the spatial encoding of the channel sensitivity. The concept allows a direct coupling of high-resolution crystal arrays to the sensor with a reduced amount of readout channels. The theory of sensitivity encoding is detailed and linked to compressed sensing to compute unique sparse solutions. Two devices have been designed using one- and two-dimensional linear sensitivity encoding with eight and four readout channels, respectively. Flood histograms of both devices show the capability to precisely identify all 4 × 4 LYSO crystals with dimensions of 0.93 × 0.93 × 10 mm3. For these crystals, the energy and time resolution (MV ± SD) of the devices with one (two)-dimensional encoding have been measured to be 12.3 · (1 ± 0.047)% (13.7 · (1 ± 0.047)%) around 511 keV with a paired coincidence time resolution (full width at half maximum) of 462 · (1 ± 0.054) ps (452 · (1 ± 0.078) ps).

Design of high energy laser pulse delivery in a multimode fiber for photoacoustic tomography.

PubMed

Ai, Min; Shu, Weihang; Salcudean, Tim; Rohling, Robert; Abolmaesumi, Purang; Tang, Shuo

2017-07-24

In photoacoustic tomography (PAT), delivering high energy pulses through optical fiber is critical for achieving high quality imaging. A fiber coupling scheme with a beam homogenizer is demonstrated for coupling high energy pulses in a single multimode fiber. This scheme can benefit PAT applications that require miniaturized illumination or internal illumination with a small fiber. The beam homogenizer is achieved by using a cross cylindrical lens array, which provides a periodic spatial modulation on the phase of the input light. Thus the lens array acts as a phase grating which diffracts the beam into a 2D diffraction pattern. Both theoretical analysis and experiments demonstrate that the focused beam can be split into a 2D spot array that can reduce the peak power on the fiber tip surface and thus enhance the coupling performance. The theoretical analysis of the intensity distribution of the focused beam is carried out by Fourier optics. In experiments, coupled energy at 48 mJ/pulse and 60 mJ/pulse have been achieved and the corresponding coupling efficiency is 70% and 90% in a 1000-μm and a 1500-μm-core-diameter fiber, respectively. The high energy pulses delivered by the multimode fiber are further tested for PAT imaging in phantoms. PAT imaging of a printed dot array shows a large illumination area of 7 cm 2 under 5 mm thick chicken breast tissue. In vivo imaging is also demonstrated on the human forearm. The large improvement in coupling energy can potentially benefit PAT with single fiber delivery to achieve large area imaging and deep penetration detection.

Optical diffraction tomography microscopy with transport of intensity equation using a light-emitting diode array

NASA Astrophysics Data System (ADS)

Li, Jiaji; Chen, Qian; Zhang, Jialin; Zhang, Zhao; Zhang, Yan; Zuo, Chao

2017-08-01

Optical diffraction tomography (ODT) is an effective label-free technique for quantitatively refractive index imaging, which enables long-term monitoring of the internal three-dimensional (3D) structures and molecular composition of biological cells with minimal perturbation. However, existing optical tomographic methods generally rely on interferometric configuration for phase measurement and sophisticated mechanical systems for sample rotation or beam scanning. Thereby, the measurement is suspect to phase error coming from the coherent speckle, environmental vibrations, and mechanical error during data acquisition process. To overcome these limitations, we present a new ODT technique based on non-interferometric phase retrieval and programmable illumination emitting from a light-emitting diode (LED) array. The experimental system is built based on a traditional bright field microscope, with the light source replaced by a programmable LED array, which provides angle-variable quasi-monochromatic illumination with an angular coverage of ±37 degrees in both x and y directions (corresponding to an illumination numerical aperture of ∼0.6). Transport of intensity equation (TIE) is utilized to recover the phase at different illumination angles, and the refractive index distribution is reconstructed based on the ODT framework under first Rytov approximation. The missing-cone problem in ODT is addressed by using the iterative non-negative constraint algorithm, and the misalignment of the LED array is further numerically corrected to improve the accuracy of refractive index quantification. Experiments on polystyrene beads and thick biological specimens show that the proposed approach allows accurate refractive index reconstruction while greatly reduced the system complexity and environmental sensitivity compared to conventional interferometric ODT approaches.

Evaluation of a new mid-scala cochlear implant electrode using microcomputed tomography.

PubMed

Frisch, Christopher D; Carlson, Matthew L; Lane, John I; Driscoll, Colin L W

2015-12-01

To investigate electrode position, depth of insertion, and electrode contact using an electrode array with a mid-scala design following round window (RW) and cochleostomy insertion. Eight fresh-frozen cadaveric bones were implanted; half via a RW approach and half through an anteroinferior cochleostomy using a styleted mid-scala electrode design. Microcomputed tomography was used to acquire oblique coronal and oblique axial reformations. Individual electrode positions along each array, insertional depth, and electrode contact were determined using National Institutes of Health Image J software. All electrodes were inserted without significant resistance. The average angular depth of insertion was 436.5° for the RW group and 422.7° for the cochleostomy group. All electrodes acquired a perimodiolar position in the proximal segment and a lateral wall position at the basal turn, regardless of approach. Electrodes distal to the basal turn demonstrated a variable location, with 78% mid scala. One cochleostomy array fractured through the interscalar partition (ISP), acquiring a scala vestibuli position. The odds ratio for either abutting the modiolus, ISP, lateral wall or floor, or fracturing through the ISP were 2.7 times more likely following a cochleostomy insertion (P = .032). The styleted mid-scala electrode design acquires a proximal perimodiolar position, a lateral wall location, as it traverses the basal turn, and most commonly a mid-scala position in the distal array. Interscalar excursion occurred in one of the cochleostomy insertions. Cochleostomy insertion is more likely to result in ultimate final electrode position adjacent to critical intracochlear structures. NA. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

A novel scalable manufacturing process for the production of hydrogel-forming microneedle arrays.

PubMed

Lutton, Rebecca E M; Larrañeta, Eneko; Kearney, Mary-Carmel; Boyd, Peter; Woolfson, A David; Donnelly, Ryan F

2015-10-15

A novel manufacturing process for fabricating microneedle arrays (MN) has been designed and evaluated. The prototype is able to successfully produce 14×14 MN arrays and is easily capable of scale-up, enabling the transition from laboratory to industry and subsequent commercialisation. The method requires the custom design of metal MN master templates to produce silicone MN moulds using an injection moulding process. The MN arrays produced using this novel method was compared with centrifugation, the traditional method of producing aqueous hydrogel-forming MN arrays. The results proved that there was negligible difference between either methods, with each producing MN arrays with comparable quality. Both types of MN arrays can be successfully inserted in a skin simulant. In both cases the insertion depth was approximately 60% of the needle length and the height reduction after insertion was in both cases approximately 3%. Copyright © 2015 Elsevier B.V. All rights reserved.

A novel scalable manufacturing process for the production of hydrogel-forming microneedle arrays

PubMed Central

Lutton, Rebecca E.M.; Larrañeta, Eneko; Kearney, Mary-Carmel; Boyd, Peter; Woolfson, A.David; Donnelly, Ryan F.

2015-01-01

A novel manufacturing process for fabricating microneedle arrays (MN) has been designed and evaluated. The prototype is able to successfully produce 14 × 14 MN arrays and is easily capable of scale-up, enabling the transition from laboratory to industry and subsequent commercialisation. The method requires the custom design of metal MN master templates to produce silicone MN moulds using an injection moulding process. The MN arrays produced using this novel method was compared with centrifugation, the traditional method of producing aqueous hydrogel-forming MN arrays. The results proved that there was negligible difference between either methods, with each producing MN arrays with comparable quality. Both types of MN arrays can be successfully inserted in a skin simulant. In both cases the insertion depth was approximately 60% of the needle length and the height reduction after insertion was in both cases approximately 3%. PMID:26302858

Development of a stationary chest tomosynthesis system using carbon nanotube x-ray source array

NASA Astrophysics Data System (ADS)

Shan, Jing

X-ray imaging system has shown its usefulness for providing quick and easy access of imaging in both clinic settings and emergency situations. It greatly improves the workflow in hospitals. However, the conventional radiography systems, lacks 3D information in the images. The tissue overlapping issue in the 2D projection image result in low sensitivity and specificity. Both computed tomography and digital tomosynthesis, the two conventional 3D imaging modalities, requires a complex gantry to mechanically translate the x-ray source to various positions. Over the past decade, our research group has developed a carbon nanotube (CNT) based x-ray source technology. The CNT x-ray sources allows compacting multiple x-ray sources into a single x-ray tube. Each individual x-ray source in the source array can be electronically switched. This technology allows development of stationary tomographic imaging modalities without any complex mechanical gantries. The goal of this work is to develop a stationary digital chest tomosynthesis (s-DCT) system, and implement it for a clinical trial. The feasibility of s-DCT was investigated. It is found that the CNT source array can provide sufficient x-ray output for chest imaging. Phantom images have shown comparable image qualities as conventional DCT. The s-DBT system was then used to study the effects of source array configurations and tomosynthesis image quality, and the feasibility of a physiological gated s-DCT. Using physical measures for spatial resolution, the 2D source configuration was shown to have improved depth resolution and comparable in-plane resolution. The prospective gated tomosynthesis images have shown substantially reduction of image blur associated with lung motions. The system was also used to investigate the feasibility of using s-DCT as a diagnosis and monitoring tools for cystic fibrosis patients. A new scatter reduction methods for s-DCT was also studied. Finally, a s-DCT system was constructed by retrofitting the source array to a Carestream digital radiography system. The system passed the electrical and radiation safety tests, and was installed in Marsico Hall. The patient trial started in March of 2015, and the first patient was successfully imaged.

Three-dimensional structural dynamics and fluctuations of DNA-nanogold conjugates by individual-particle electron tomography

NASA Astrophysics Data System (ADS)

Zhang, Lei; Lei, Dongsheng; Smith, Jessica M.; Zhang, Meng; Tong, Huimin; Zhang, Xing; Lu, Zhuoyang; Liu, Jiankang; Alivisatos, A. Paul; Ren, Gang

2016-03-01

DNA base pairing has been used for many years to direct the arrangement of inorganic nanocrystals into small groupings and arrays with tailored optical and electrical properties. The control of DNA-mediated assembly depends crucially on a better understanding of three-dimensional structure of DNA-nanocrystal-hybridized building blocks. Existing techniques do not allow for structural determination of these flexible and heterogeneous samples. Here we report cryo-electron microscopy and negative-staining electron tomography approaches to image, and three-dimensionally reconstruct a single DNA-nanogold conjugate, an 84-bp double-stranded DNA with two 5-nm nanogold particles for potential substrates in plasmon-coupling experiments. By individual-particle electron tomography reconstruction, we obtain 14 density maps at ~2-nm resolution. Using these maps as constraints, we derive 14 conformations of dsDNA by molecular dynamics simulations. The conformational variation is consistent with that from liquid solution, suggesting that individual-particle electron tomography could be an expected approach to study DNA-assembling and flexible protein structure and dynamics.

Entropic Comparison of Atomic-Resolution Electron Tomography of Crystals and Amorphous Materials.

PubMed

Collins, S M; Leary, R K; Midgley, P A; Tovey, R; Benning, M; Schönlieb, C-B; Rez, P; Treacy, M M J

2017-10-20

Electron tomography bears promise for widespread determination of the three-dimensional arrangement of atoms in solids. However, it remains unclear whether methods successful for crystals are optimal for amorphous solids. Here, we explore the relative difficulty encountered in atomic-resolution tomography of crystalline and amorphous nanoparticles. We define an informational entropy to reveal the inherent importance of low-entropy zone-axis projections in the reconstruction of crystals. In turn, we propose considerations for optimal sampling for tomography of ordered and disordered materials.

Lensless transport-of-intensity phase microscopy and tomography with a color LED matrix

NASA Astrophysics Data System (ADS)

Zuo, Chao; Sun, Jiasong; Zhang, Jialin; Hu, Yan; Chen, Qian

2015-07-01

We demonstrate lens-less quantitative phase microscopy and diffraction tomography based on a compact on-chip platform, using only a CMOS image sensor and a programmable color LED array. Based on multi-wavelength transport-of- intensity phase retrieval and multi-angle illumination diffraction tomography, this platform offers high quality, depth resolved images with a lateral resolution of ˜3.7μm and an axial resolution of ˜5μm, over wide large imaging FOV of 24mm2. The resolution and FOV can be further improved by using a larger image sensors with small pixels straightforwardly. This compact, low-cost, robust, portable platform with a decent imaging performance may offer a cost-effective tool for telemedicine needs, or for reducing health care costs for point-of-care diagnostics in resource-limited environments.

The orderly nano array of truncated octahedra Cu2O nanocrystals with the enhancement of visible light photocatalytic activity

NASA Astrophysics Data System (ADS)

Wei, Xiaofeng; Pan, Jiaqi; Mei, Jie; Zheng, Yingying; Cui, Can; Li, Chaorong

2018-07-01

The orderly nano array is able to improve the light utilization efficiency and has been thought to be a promising way for advancing photocatalysis. The orderly nano array of truncated octahedra Cu2O nanocrystals have been successfully fabricated by the facile solution-based one-step reduction and self-assembly method. The results of XRD, SEM and TEM indicate that the Cu2O nano array is successfully assembled on the Si substrate. The photocatalytic activity of the Cu2O orderly nano array is investigated under visible light irradiation, and it is demonstrated to be significantly enhanced after the Cu2O is self-assembled orderly. Furthermore, the surface orderly structure of the nano array is considered as the main reason for the enhancement.

Cadaveric feasibility study of da Vinci Si-assisted cochlear implant with augmented visual navigation for otologic surgery.

PubMed

Liu, Wen P; Azizian, Mahdi; Sorger, Jonathan; Taylor, Russell H; Reilly, Brian K; Cleary, Kevin; Preciado, Diego

2014-03-01

To our knowledge, this is the first reported cadaveric feasibility study of a master-slave-assisted cochlear implant procedure in the otolaryngology-head and neck surgery field using the da Vinci Si system (da Vinci Surgical System; Intuitive Surgical, Inc). We describe the surgical workflow adaptations using a minimally invasive system and image guidance integrating intraoperative cone beam computed tomography through augmented reality. To test the feasibility of da Vinci Si-assisted cochlear implant surgery with augmented reality, with visualization of critical structures and facilitation with precise cochleostomy for electrode insertion. Cadaveric case study of bilateral cochlear implant approaches conducted at Intuitive Surgical Inc, Sunnyvale, California. Bilateral cadaveric mastoidectomies, posterior tympanostomies, and cochleostomies were performed using the da Vinci Si system on a single adult human donor cadaveric specimen. Radiographic confirmation of successful cochleostomies, placement of a phantom cochlear implant wire, and visual confirmation of critical anatomic structures (facial nerve, cochlea, and round window) in augmented stereoendoscopy. With a surgical mean time of 160 minutes per side, complete bilateral cochlear implant procedures were successfully performed with no violation of critical structures, notably the facial nerve, chorda tympani, sigmoid sinus, dura, or ossicles. Augmented reality image overlay of the facial nerve, round window position, and basal turn of the cochlea was precise. Postoperative cone beam computed tomography scans confirmed successful placement of the phantom implant electrode array into the basal turn of the cochlea. To our knowledge, this is the first study in the otolaryngology-head and neck surgery literature examining the use of master-slave-assisted cochleostomy with augmented reality for cochlear implants using the da Vinci Si system. The described system for cochleostomy has the potential to improve the surgeon's confidence, as well as surgical safety, efficiency, and precision by filtering tremor. The integration of augmented reality may be valuable for surgeons dealing with complex cases of congenital anatomic abnormality, for revision cochlear implant with distorted anatomy and poorly pneumatized mastoids, and as a method of interactive teaching. Further research into the cost-benefit ratio of da Vinci Si-assisted otologic surgery, as well as refinements of the proposed workflow, are required before considering clinical studies.

The Atacama Large Millimeter/Submillimeter Array (ALMA) - A Successful Three-Way International Partnership Without a Majority Stakeholder

NASA Astrophysics Data System (ADS)

Vanden Bout, Paul A.

2013-04-01

The Atacama Millimeter/Submillimeter Array (ALMA) is the largest ground-based astronomical facility built to date. It's size and challenging site required an international effort. This talk presents the partnership structure, management challenges, current status, and examples of early scientific successes.

Coincidence detection of spatially correlated photon pairs with a monolithic time-resolving detector array.

PubMed

Unternährer, Manuel; Bessire, Bänz; Gasparini, Leonardo; Stoppa, David; Stefanov, André

2016-12-12

We demonstrate coincidence measurements of spatially entangled photons by means of a multi-pixel based detection array. The sensor, originally developed for positron emission tomography applications, is a fully digital 8×16 silicon photomultiplier array allowing not only photon counting but also per-pixel time stamping of the arrived photons with an effective resolution of 265 ps. Together with a frame rate of 500 kfps, this property exceeds the capabilities of conventional charge-coupled device cameras which have become of growing interest for the detection of transversely correlated photon pairs. The sensor is used to measure a second-order correlation function for various non-collinear configurations of entangled photons generated by spontaneous parametric down-conversion. The experimental results are compared to theory.

Ambient Seismic Noise Interferometry on the Island of Hawai`i

NASA Astrophysics Data System (ADS)

Ballmer, Silke

Ambient seismic noise interferometry has been successfully applied in a variety of tectonic settings to gain information about the subsurface. As a passive seismic technique, it extracts the coherent part of ambient seismic noise in-between pairs of seismic receivers. Measurements of subtle temporal changes in seismic velocities, and high-resolution tomographic imaging are then possible - two applications of particular interest for volcano monitoring. Promising results from other volcanic settings motivate its application in Hawai'i, with this work being the first to explore its potential. The dataset used for this purpose was recorded by the Hawaiian Volcano Observatory's permanent seismic network on the Island of Hawai'i. It spans 2.5 years from 5/2007 to 12/2009 and covers two distinct sources of volcanic tremor. After applying standard processing for ambient seismic noise interferometry, we find that volcanic tremor strongly affects the extracted noise information not only close to the tremor source, but unexpectedly, throughout the island-wide network. Besides demonstrating how this long-range observability of volcanic tremor can be used to monitor volcanic activity in the absence of a dense seismic array, our results suggest that care must be taken when applying ambient seismic noise interferometry in volcanic settings. In a second step, we thus exclude days that show signs of volcanic tremor, reducing the dataset to three months, and perform ambient seismic noise tomography. The resulting two-dimensional Rayleigh wave group velocity maps for 0.1 - 0.9 Hz compare very well with images from previous travel time tomography, both, for the main volcanic structures at low frequencies as well as for smaller features at mid-to-high frequencies - a remarkable observation for the temporally truncated dataset. These robust results suggest that ambient seismic noise tomography in Hawai'i is suitable 1) to provide a three-dimensional S-wave model for the volcanoes and 2) to be used for repeated time-sensitive tomography, even though volcanic tremor frequently obscures ambient noise analyses. However, the noise characteristics and the wavefield in Hawai'i in general remain to be investigated in more detail in order to measure unbiased temporal velocity changes.

Electrical resistance tomography using steel cased boreholes as electrodes

DOEpatents

Daily, W.D.; Ramirez, A.L.

1999-06-22

An electrical resistance tomography method is described which uses steel cased boreholes as electrodes. The method enables mapping the electrical resistivity distribution in the subsurface from measurements of electrical potential caused by electrical currents injected into an array of electrodes in the subsurface. By use of current injection and potential measurement electrodes to generate data about the subsurface resistivity distribution, which data is then used in an inverse calculation, a model of the electrical resistivity distribution can be obtained. The inverse model may be constrained by independent data to better define an inverse solution. The method utilizes pairs of electrically conductive (steel) borehole casings as current injection electrodes and as potential measurement electrodes. The greater the number of steel cased boreholes in an array, the greater the amount of data is obtained. The steel cased boreholes may be utilized for either current injection or potential measurement electrodes. The subsurface model produced by this method can be 2 or 3 dimensional in resistivity depending on the detail desired in the calculated resistivity distribution and the amount of data to constrain the models. 2 figs.

Electrical resistance tomography using steel cased boreholes as electrodes

DOEpatents

Daily, William D.; Ramirez, Abelardo L.

1999-01-01

An electrical resistance tomography method using steel cased boreholes as electrodes. The method enables mapping the electrical resistivity distribution in the subsurface from measurements of electrical potential caused by electrical currents injected into an array of electrodes in the subsurface. By use of current injection and potential measurement electrodes to generate data about the subsurface resistivity distribution, which data is then used in an inverse calculation, a model of the electrical resistivity distribution can be obtained. The inverse model may be constrained by independent data to better define an inverse solution. The method utilizes pairs of electrically conductive (steel) borehole casings as current injection electrodes and as potential measurement electrodes. The greater the number of steel cased boreholes in an array, the greater the amount of data is obtained. The steel cased boreholes may be utilized for either current injection or potential measurement electrodes. The subsurface model produced by this method can be 2 or 3 dimensional in resistivity depending on the detail desired in the calculated resistivity distribution and the amount of data to constain the models.

Flame monitoring of a model swirl injector using 1D tunable diode laser absorption spectroscopy tomography

NASA Astrophysics Data System (ADS)

Liu, Chang; Cao, Zhang; Li, Fangyan; Lin, Yuzhen; Xu, Lijun

2017-05-01

Distributions of temperature and H2O concentration in a swirling flame are critical to evaluate the performance of a gas turbine combustor. In this paper, 1D tunable diode laser absorption spectroscopy tomography (1D-TDLAST) was introduced to monitor swirling flames generated from a model swirl injector by simultaneously reconstructing the rotationally symmetric distributions of temperature and H2O concentration. The optical system was sufficiently simplified by introducing only one fan-beam illumination and a linear detector array of 12 equally-spaced photodetectors. The fan-beam illumination penetrated a cross section of interest in the swirling flame and the transmitted intensities were detected by the detector array. With the transmitted intensities in hand, projections were extracted and employed by a 1D tomographic algorithm to reconstruct the distributions of temperature and H2O concentration. The route of the precessing vortex core generated in the swirling flame can be easily inferred from the reconstructed profiles of temperature and H2O concentration at different heights above the nozzle of the swirl injector.

Study on laser-assisted drug delivery with optical coherence tomography

NASA Astrophysics Data System (ADS)

Tsai, Wen-Guei; Tsai, Ting-Yen; Yang, Chih-Hsun; Tsai, Meng-Tsan

2017-04-01

The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. Nail plate divided into three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. Moreover, optical coherence tomography (OCT) is implemented for real-time monitoring of the laser-skin tissue interaction, sparing the patient from invasive surgical sampling procedure. Observations of drug diffusion through the induced MAZ array are achieved by evaluating the time-dependent OCT intensity variance. Subsequently, nails are treated with cream and liquid topical drugs to investigate the feasibility and diffusion efficacy of laser-assisted drug delivery. Our results show that fractional CO2 laser improves the efficacy of topical drug delivery in the nail plate, and that OCT could potentially be used for in vivo monitoring of the depth of laser penetration as well as real-time observations of drug delivery.

Filling the gap: adding super-resolution to array tomography for correlated ultrastructural and molecular identification of electrical synapses at the C. elegans connectome.

PubMed

Markert, Sebastian Matthias; Britz, Sebastian; Proppert, Sven; Lang, Marietta; Witvliet, Daniel; Mulcahy, Ben; Sauer, Markus; Zhen, Mei; Bessereau, Jean-Louis; Stigloher, Christian

2016-10-01

Correlating molecular labeling at the ultrastructural level with high confidence remains challenging. Array tomography (AT) allows for a combination of fluorescence and electron microscopy (EM) to visualize subcellular protein localization on serial EM sections. Here, we describe an application for AT that combines near-native tissue preservation via high-pressure freezing and freeze substitution with super-resolution light microscopy and high-resolution scanning electron microscopy (SEM) analysis on the same section. We established protocols that combine SEM with structured illumination microscopy (SIM) and direct stochastic optical reconstruction microscopy (dSTORM). We devised a method for easy, precise, and unbiased correlation of EM images and super-resolution imaging data using endogenous cellular landmarks and freely available image processing software. We demonstrate that these methods allow us to identify and label gap junctions in Caenorhabditis elegans with precision and confidence, and imaging of even smaller structures is feasible. With the emergence of connectomics, these methods will allow us to fill in the gap-acquiring the correlated ultrastructural and molecular identity of electrical synapses.

MOEMS optical delay line for optical coherence tomography

NASA Astrophysics Data System (ADS)

Choudhary, Om P.; Chouksey, S.; Sen, P. K.; Sen, P.; Solanki, J.; Andrews, J. T.

2014-09-01

Micro-Opto-Electro-Mechanical optical coherence tomography, a lab-on-chip for biomedical applications is designed, studied, fabricated and characterized. To fabricate the device standard PolyMUMPS processes is adopted. We report the utilization of electro-optic modulator for a fast scanning optical delay line for time domain optical coherence tomography. Design optimization are performed using Tanner EDA while simulations are performed using COMSOL. The paper summarizes various results and fabrication methodology adopted. The success of the device promises a future hand-held or endoscopic optical coherence tomography for biomedical applications.

Fabricating High-Resolution X-Ray Collimators

NASA Technical Reports Server (NTRS)

Appleby, Michael; Atkinson, James E.; Fraser, Iain; Klinger, Jill

2008-01-01

A process and method for fabricating multi-grid, high-resolution rotating modulation collimators for arcsecond and sub-arcsecond x-ray and gamma-ray imaging involves photochemical machining and precision stack lamination. The special fixturing and etching techniques that have been developed are used for the fabrication of multiple high-resolution grids on a single array substrate. This technology has application in solar and astrophysics and in a number of medical imaging applications including mammography, computed tomography (CT), single photon emission computed tomography (SPECT), and gamma cameras used in nuclear medicine. This collimator improvement can also be used in non-destructive testing, hydrodynamic weapons testing, and microbeam radiation therapy.

Design and development of a dedicated mammary and axillary region positron emission tomography system

NASA Astrophysics Data System (ADS)

Doshi, Niraj Kumar

Breast cancer is the second leading cause of cancer death in women. Currently, mammography and physical breast examination, both non-invasive techniques, provide the two most effective methods available for screening potential breast cancer patients. During the management of patients, however, several invasive techniques such as axillary lymph node dissection, core biopsies and lumpectomies, are utilized to determine the stage or malignancy of the disease with significant cost and morbidity associated with them. Positron Emission Tomography (PET), using [F-18] fluorodeoxyglucose (FDG) tracer is a sensitive and non-invasive imaging modality that may be a cost-effective alternative to certain invasive procedures. In this project we have developed a low cost, high performance, dedicated PET camera (maxPET) for mammary and axillary region imaging. The system consists of two 15x15 cm2 planar scintillation detector arrays composed of modular detectors operating in coincidence. The modular detectors are comprised of a 9x9 array of 3x3x20 mm3 lutetiurn oxyorthosilicate (LSO) detector elements, read out by a 5x5 array of position- sensitive photomultiplier tubes. The average measured intrinsic spatial resolution of a detector module is 2.26 mm with a sensitivity of up to 40% for a central point source. The measured coincidence timing resolution for two modules is 2.4 ns. The average energy resolution measured across the entire two detector plates is 21.6%. The coincidence timing resolution for the entire system is 8.1 ns. A line bar phantom was imaged and images were reconstructed using the focal plane tomography algorithm. A 4 mm projection image resolution was measured based on profiles taken through the line bar phantom images. The goal of the maxPET system will be to aid in breast cancer patient management by assisting in imaging women with dense, fibro-glandular breasts, detecting axillary lymph node metastases without surgery, monitoring chemotherapy effectiveness and assisting in visualization of recurrence and tumoral boundaries.

Local Earthquake P-wave Tomography at Mount St. Helens with the iMUSH Broadband Array

NASA Astrophysics Data System (ADS)

Ulberg, C. W.; Creager, K. C.; Moran, S. C.; Abers, G. A.; Crosbie, K.; Crosson, R. S.; Denlinger, R. P.; Thelen, W. A.; Hansen, S. M.; Schmandt, B.; Kiser, E.; Levander, A.; Bachmann, O.

2016-12-01

We deployed 70 broadband seismometers in the summer of 2014 to image the seismic velocity structure beneath Mount St. Helens (MSH), Washington, as part of the collaborative imaging Magma Under St. Helens (iMUSH) project. Our goal is to illuminate the MSH magmatic system by integrating all portions of the iMUSH experiment, including active- and passive-source tomography, ambient-noise tomography, seismicity, receiver functions, magnetotellurics, and petrology. The broadband array has a diameter of 100 km centered on MSH with an average station spacing of 10 km, and was deployed through summer 2016. It is augmented by dozens of permanent stations in the area. We determine P-wave arrival times and also incorporate picks from the permanent network. There were more than 250 local events during the first year of iMUSH broadband recording, which have provided over 11,000 high-quality arrival times. The iMUSH experiment included 23 active shots in 2014 that were recorded with good signal-to-noise ratios across the entire array. Direct raypaths from local earthquakes and active shots reach 15-20 km depth beneath MSH. We use the program struct3DP to iteratively invert travel times to obtain a 3-D seismic velocity model and relocate hypocenters. Travel times are computed using a 3-D eikonal-equation solver. We are expanding our analysis to include S-wave arrivals from local events. The preliminary 3-D model shows low P-wave speeds along the St. Helens seismic zone, striking NNW-SSE of MSH from near the surface to where we lose resolution at 15-20km depth. This seismic zone coincides with a sharp boundary in Moho reflectivity that has been interpreted as the eastern boundary of a serpentinized mantle wedge (Hansen et al, 2016, submitted). We speculate that the seismic zone and low wave speeds are related to fluids rising from the eastern boundary of the wedge.

Array-type miniature interferometer as the core optical microsystem of an optical coherence tomography device for tissue inspection

NASA Astrophysics Data System (ADS)

Passilly, Nicolas; Perrin, Stéphane; Lullin, Justine; Albero, Jorge; Bargiel, Sylwester; Froehly, Luc; Gorecki, Christophe; Krauter, Johann; Osten, Wolfgang; Wang, Wei-Shan; Wiemer, Maik

2016-04-01

Some of the critical limitations for widespread use in medical applications of optical devices, such as confocal or optical coherence tomography (OCT) systems, are related to their cost and large size. Indeed, although quite efficient systems are available on the market, e.g. in dermatology, they equip only a few hospitals and hence, are far from being used as an early detection tool, for instance in screening of patients for early detection of cancers. In this framework, the VIAMOS project aims at proposing a concept of miniaturized, batch-fabricated and lower-cost, OCT system dedicated to non-invasive skin inspection. In order to image a large skin area, the system is based on a full-field approach. Moreover, since it relies on micro-fabricated devices whose fields of view are limited, 16 small interferometers are arranged in a dense array to perform multi-channel simultaneous imaging. Gaps between each channel are then filled by scanning of the system followed by stitching. This approach allows imaging a large area without the need of large optics. It also avoids the use of very fast and often expensive laser sources, since instead of a single point detector, almost 250 thousands pixels are used simultaneously. The architecture is then based on an array of Mirau interferometers which are interesting for their vertical arrangement compatible with vertical assembly at the wafer-level. Each array is consequently a local part of a stack of seven wafers. This stack includes a glass lens doublet, an out-of-plane actuated micro-mirror for phase shifting, a spacer and a planar beam-splitter. Consequently, different materials, such as silicon and glass, are bonded together and well-aligned thanks to lithographic-based fabrication processes.

Photoacoustic projection imaging using an all-optical detector array

NASA Astrophysics Data System (ADS)

Bauer-Marschallinger, J.; Felbermayer, K.; Berer, T.

2018-02-01

We present a prototype for all-optical photoacoustic projection imaging. By generating projection images, photoacoustic information of large volumes can be retrieved with less effort compared to common photoacoustic computed tomography where many detectors and/or multiple measurements are required. In our approach, an array of 60 integrating line detectors is used to acquire photoacoustic waves. The line detector array consists of fiber-optic MachZehnder interferometers, distributed on a cylindrical surface. From the measured variation of the optical path lengths of the interferometers, induced by photoacoustic waves, a photoacoustic projection image can be reconstructed. The resulting images represent the projection of the three-dimensional spatial light absorbance within the imaged object onto a two-dimensional plane, perpendicular to the line detector array. The fiber-optic detectors achieve a noise-equivalent pressure of 24 Pascal at a 10 MHz bandwidth. We present the operational principle, the structure of the array, and resulting images. The system can acquire high-resolution projection images of large volumes within a short period of time. Imaging large volumes at high frame rates facilitates monitoring of dynamic processes.

Measurement of high-voltage and radiation-damage limitations to advanced solar array performance

NASA Technical Reports Server (NTRS)

Guidice, D. A.; Severance, P. S.; Keinhardt, K. C.

1991-01-01

A description is given of the reconfigured Photovoltaic Array Space Power (PASP) Plus experiment: its objectives, solar-array complement, and diagnostic sensors. Results from a successful spaceflight will lead to a better understanding of high-voltage and radiation-damage limitations in the operation of new-technology solar arrays.

Factors influencing infants’ ability to update object representations in memory

PubMed Central

Moher, Mariko; Feigenson, Lisa

2013-01-01

Remembering persisting objects over occlusion is critical to representing a stable environment. Infants remember hidden objects at multiple locations and can update their representation of a hidden array when an object is added or subtracted. However, the factors influencing these updating abilities have received little systematic exploration. Here we examined the flexibility of infants’ ability to update object representations. We tested 11-month-olds in a looking-time task in which objects were added to or subtracted from two hidden arrays. Across five experiments, infants successfully updated their representations of hidden arrays when the updating occurred successively at one array before beginning at the other. But when updating required alternating between two arrays, infants failed. However, simply connecting the two arrays with a thin strip of foam-core led infants to succeed. Our results suggest that infants’ construal of an event strongly affects their ability to update memory representations of hidden objects. When construing an event as containing multiple updates to the same array, infants succeed, but when construing the event as requiring the revisiting and updating of previously attended arrays, infants fail. PMID:24049245

Crustal and upper mantle structure of the Hangay Dome, central Mongolia

NASA Astrophysics Data System (ADS)

Stachnik, J. C.; Meltzer, A.; Tsaagan, B.; Munkhuu, U.; Russo, R.; Souza, S.; Martin, P.

2013-12-01

The origin and support of high topography within continental interiors away from active tectonic margins remains a fundamental question in the dynamics and deformation of continents. The Hangay Dome in central Mongolia is one such region that is a broad regional uplift with average elevation of about 2 km, sitting between two large strike-slip faults, the Bulnay Fault to the north and the Gobi-Altay Fault to the south. Both of these faults are seismically active and have experienced M8+ earthquakes as recently as 1957. This portion of the Mongolian Plateau is approximately 300 km south of the Baikal Rift and located at the northern margin of the diffuse-deformation field in Central Asia, adjacent to the Siberian Craton. From previous research, the dynamic support of the Hangay Dome has been attributed to both crustal thickening and low density upper mantle material. However, seismic data leading to these interpretations have been limited to global tomographic models and sparse regional sampling of the wave field leaving the question unresolved. To address this major question in plate tectonic theory, in June 2012 a temporary IRIS/PASSCAL/University of Florida array of 72 seismic stations was deployed around the Hangay Dome to determine lithospheric structure in the region. Preliminary results from the first of two years of data are shown from receiver function analysis, ambient noise surface wave tomography, and teleseismic travel time residual analysis. Using teleseismic waveform records from over 300 earthquakes above M5.5 between 30 and 90 degrees epicentral distance, crustal thickness measurements from H-k stacking of receiver functions range from 42 km to 57 km across the array, with thicker crust beneath the highest topography. At each station the bulk crustal Vp/Vs ratio is also determined with median value for the array of 1.77, perhaps indicating a more mafic composition crust in the region.Teleseismic P-wave travel time residuals generally diminish from south to north across the array consistent with thinning crust, however the depth resolution and magnitude of seismic wavespeed anomalies will be further explored with three-dimensional finite-frequency tomography. Constraints on crustal shear wave velocity from ambient noise surface wave tomography complement both the receiver function analysis and teleseismic tomography. Initial inversions of phase velocity dispersion curves in the central Hangay indicate an average crustal Vs of 3.6 km/s within the Hangay Dome, which translates to an average Vp of 6.4 km/s using Vp/Vs of 1.77. Further refinement of current analysis and an additional year of recording will reveal the first high resolution lithospheric scale model in the region.

Three-dimensional fine structure of the organization of microtubules in neurite varicosities by ultra-high voltage electron microscope tomography.

PubMed

Nishida, Tomoki; Yoshimura, Ryoichi; Endo, Yasuhisa

2017-09-01

Neurite varicosities are highly specialized compartments that are involved in neurotransmitter/ neuromodulator release and provide a physiological platform for neural functions. However, it remains unclear how microtubule organization contributes to the form of varicosity. Here, we examine the three-dimensional structure of microtubules in varicosities of a differentiated PC12 neural cell line using ultra-high voltage electron microscope tomography. Three-dimensional imaging showed that a part of the varicosities contained an accumulation of organelles that were separated from parallel microtubule arrays. Further detailed analysis using serial sections and whole-mount tomography revealed microtubules running in a spindle shape of swelling in some other types of varicosities. These electron tomographic results showed that the structural diversity and heterogeneity of microtubule organization supported the form of varicosities, suggesting that a different distribution pattern of microtubules in varicosities is crucial to the regulation of varicosities development.

Seismic Tomography and the Development of a State Velocity Profile

NASA Astrophysics Data System (ADS)

Marsh, S. J.; Nakata, N.

2017-12-01

Earthquakes have been a growing concern in the State of Oklahoma in the last few years and as a result, accurate earthquake location is of utmost importance. This means using a high resolution velocity model with both lateral and vertical variations. Velocity data is determined using ambient noise seismic interferometry and tomography. Passive seismic data was acquired from multiple IRIS networks over the span of eight years (2009-2016) and filtered for earthquake removal to obtain the background ambient noise profile for the state. Seismic Interferometry is applied to simulate ray paths between stations, this is done with each possible station pair for highest resolution. Finally the method of seismic tomography is used to extract the velocity data and develop the state velocity map. The final velocity profile will be a compilation of different network analyses due to changing station availability from year to year. North-Central Oklahoma has a dense seismic network and has been operating for the past few years. The seismic stations are located here because this is the most seismically active region. Other parts of the state have not had consistent coverage from year to year, and as such a reliable and high resolution velocity profile cannot be determined from this network. However, the Transportable Array (TA) passed through Oklahoma in 2014 and provided a much wider and evenly spaced coverage. The goal of this study is to ultimately combine these two arrays over time, and provide a high quality velocity profile for the State of Oklahoma.

NOY: a neutrino observatory network project based on stand alone air shower detector arrays

NASA Astrophysics Data System (ADS)

Montanet, F.; Lebrun, D.; Chauvin, J.; Lagorio, E.; Stassi, P.

2011-09-01

We have developed a self powered stand alone particle detector array dedicated to the observation of horizontal tau air showers induced by high energy neutrinos interacting in mountain rock. Air shower particle detection reaches a 100% duty cycle and is practically free of background when compared to Cherenkov light or radio techniques. It is thus better suited for rare neutrino event search. An appropriate mountain to valley topological configuration has been identified and the first array will be deployed on an inclined slope at an elevation of 1500 m facing Southern Alps near the city of Grenoble (France). A full simulation has been performed. A neutrino energy dependent mountain tomography chart is obtained using a neutrino and tau propagation code together with a detailed cartography and elevation map of the region. The array acceptance is then evaluated between 1 PeV and 100 EeV by simulating decaying tau air showers across the valley. The effective detection surface is determined by the shower lateral extension at array location and is hence much larger than the array geometrical area. The array exposure will be 1014 cm2 sr s at 100 PeV. Several independent arrays can be deployed with the aim of constituting a large distributed observatory. Some other sites are already under study. At last, special care is dedicated to the educational and outreach aspects of such a cosmic ray detector.

Ocean acoustic reverberation tomography.

PubMed

Dunn, Robert A

2015-12-01

Seismic wide-angle imaging using ship-towed acoustic sources and networks of ocean bottom seismographs is a common technique for exploring earth structure beneath the oceans. In these studies, the recorded data are dominated by acoustic waves propagating as reverberations in the water column. For surveys with a small receiver spacing (e.g., <10 km), the acoustic wave field densely samples properties of the water column over the width of the receiver array. A method, referred to as ocean acoustic reverberation tomography, is developed that uses the travel times of direct and reflected waves to image ocean acoustic structure. Reverberation tomography offers an alternative approach for determining the structure of the oceans and advancing the understanding of ocean heat content and mixing processes. The technique has the potential for revealing small-scale ocean thermal structure over the entire vertical height of the water column and along long survey profiles or across three-dimensional volumes of the ocean. For realistic experimental geometries and data noise levels, the method can produce images of ocean sound speed on a smaller scale than traditional acoustic tomography.

Three-dimensional structural dynamics and fluctuations of DNA-nanogold conjugates by individual-particle electron tomography

DOE PAGES

Zhang, Lei; Lei, Dongsheng; Smith, Jessica M.; ...

2016-03-30

DNA base pairing has been used for many years to direct the arrangement of inorganic nanocrystals into small groupings and arrays with tailored optical and electrical properties. The control of DNA-mediated assembly depends crucially on a better understanding of three-dimensional structure of DNA-nanocrystal-hybridized building blocks. Existing techniques do not allow for structural determination of these flexible and heterogeneous samples. Here we report cryo-electron microscopy and negative-staining electron tomography approaches to image, and three-dimensionally reconstruct a single DNA-nanogold conjugate, an 84-bp double-stranded DNA with two 5-nm nanogold particles for potential substrates in plasmon-coupling experiments. By individual-particle electron tomography reconstruction, we obtainmore » 14 density maps at ~ 2-nm resolution . Using these maps as constraints, we derive 14 conformations of dsDNA by molecular dynamics simulations. The conformational variation is consistent with that from liquid solution, suggesting that individual-particle electron tomography could be an expected approach to study DNA-assembling and flexible protein structure and dynamics.« less

Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

PubMed Central

Park, Dong-Wook; Schendel, Amelia A.; Mikael, Solomon; Brodnick, Sarah K.; Richner, Thomas J.; Ness, Jared P.; Hayat, Mohammed R.; Atry, Farid; Frye, Seth T.; Pashaie, Ramin; Thongpang, Sanitta; Ma, Zhenqiang; Williams, Justin C.

2014-01-01

Neural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its utility through optical interface experiments that use this broad spectrum transparency. These include optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography. This study demonstrates an array of interfacing abilities of the CLEAR device and its utility for neural applications. PMID:25327513

Description of a prototype emission-transmission computed tomography imaging system

NASA Technical Reports Server (NTRS)

Lang, T. F.; Hasegawa, B. H.; Liew, S. C.; Brown, J. K.; Blankespoor, S. C.; Reilly, S. M.; Gingold, E. L.; Cann, C. E.

1992-01-01

We have developed a prototype imaging system that can perform simultaneous x-ray transmission CT and SPECT phantom studies. This system employs a 23-element high-purity-germanium detector array. The detector array is coupled to a collimator with septa angled toward the focal spot of an x-ray tube. During image acquisition, the x-ray fan beam and the detector array move synchronously along an arc pivoted at the x-ray source. Multiple projections are obtained by rotating the object, which is mounted at the center of rotation of the system. The detector array and electronics can count up to 10(6) cps/element with sufficient energy-resolution to discriminate between x-rays at 100-120 kVp and gamma rays from 99mTc. We have used this device to acquire x-ray CT and SPECT images of a three-dimensional Hoffman brain phantom. The emission and transmission images may be superimposed in order to localize the emission image on the transmission map.

Exploiting the Spatio-Temporal Coherence of Ocean Ambient Noise for Passive Tomography

DTIC Science & Technology

2012-09-30

ˆ kfCij and corresponds to the entry (i,j) of cross-covariance matrix for the selected horizontal triangular array, denoted );( ˆ kfC at the...diagonal elements );( ˆ kfCii (i=1..3) of the matrix );( ˆ kfC were set to zero to mitigate the bias due to electronic noise and the large

3D shear wave velocity structure revealed with ambient noise tomography on a DAS array

NASA Astrophysics Data System (ADS)

Zeng, X.; Thurber, C. H.; Wang, H. F.; Fratta, D.

2017-12-01

An 8700-m Distributed Acoustic Sensing (DAS) cable was deployed at Brady's Hot Springs, Nevada in March 2016 in a 1.5 by 0.5 km study area. The layout of the DAS array was designed with a zig-zag geometry to obtain relatively uniform areal and varied angular coverage, providing very dense coverage with a one-meter channel spacing. This array continuously recorded signals of a vibroseis truck, earthquakes, and traffic noise during the 15-day deployment. As shown in a previous study (Zeng et al., 2017), ambient noise tomography can be applied to DAS continuous records to image shear wave velocity structure in the near surface. To avoid effects of the vibroseis truck operation, only continuous data recorded during the nighttime was used to compute noise cross-correlation functions for channel pairs within a given linear segment. The frequency band of whitening was set at 5 to 15 Hz and the length of the cross-correlation time window was set to 60 second. The phase velocities were determined using the multichannel analysis of surface waves (MASW) methodology. The phase velocity dispersion curve was then used to invert for shear wave velocity profiles. A preliminarily velocity model at Brady's Hot Springs (Lawrence Livermore National Laboratory, 2015) was used as the starting model and the sensitivity kernels of Rayleigh wave group and phase velocities were computed with this model. As the sensitivity kernel shows, shear wave velocity in the top 200 m can be constrained with Rayleigh wave group and phase velocities in our frequency band. With the picked phase velocity data, the shear wave velocity structure can be obtained via Occam's inversion (Constable et al., 1987; Lai 1998). Shear wave velocity gradually increases with depth and it is generally faster than the Lawrence Livermore National Laboratory (2015) model. Furthermore, that model has limiting constraints at shallow depth. The strong spatial variation is interpreted to reflect the different sediments and sediment thicknesses in the near surface. Shear wave velocities in the northeast corner of the tested area is high whereas loose soil reduces shear wave velocities in the central part of the tested area. This spatial variation pattern is very similar to the results obtained with the ambient noise tomography using the 238-geophone array used the experiment.

A Laboratory Approach Relating Complex Resistivity Observations to Flow and Transport in Saturated and Unsaturated Hydrologic Regimes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martins, S A; Daily, W D; Ramirez, A L

2002-01-31

Subsurface imaging technology, such as electric resistance tomography (ERT), is rapidly improving as a means for characterizing some soil properties of the near-surface hydrologic regime. While this information can be potentially useful in developing hydrologic models of the subsurface that are required for contaminant transport investigations, an image alone of the subsurface soil regime gives little or no information about how the site will respond to groundwater flow or contaminant transport. In fact, there is some question that tomographic imaging of soils alone can even provide meaningful values of hydraulic properties, such as the permeability structure, which is critical tomore » estimates of contaminant transport at a site. The main objective of this feasibility study was to initiate research on electrical imaging not just as a way to characterize the soil structure by mapping different soil types at a site but as a means of obtaining quantitative information about how a site will respond hydrologically to an infiltration event. To this end, a scaled system of electrode arrays was constructed that simulates the subsurface electrode distribution used at the LLNL Vadose Zone Observatory (VZO) where subsurface imaging of infiltration events has been investigated for several years. The electrode system was immersed in a 10,000-gallon tank to evaluate the fundamental relationship between ERT images and targets of a given volume that approximate infiltration-induced conductivity anomalies. With LDRD funds we have explored what can be initially learned about porous flow and transport using two important electrical imaging methods--electric resistance tomography (ERT) and electric impedance tomography (EIT). These tomographic methods involve passing currents (DC or AC) between two electrodes within or between electrode arrays while measuring the electric potential at the remaining electrodes. With the aid of a computer-based numerical inversion scheme, the potentials are used to solve for the electrical conductivity distribution in the region bounded by the electrode arrays. Groundwater movement resulting from a leak or surface spill will produce measurable conductivity changes that have been imaged using ERT or EIT. The kind of laboratory scale experiments supported by this work will help us to better understand the connection between imaged conductivity anomalies and the groundwater or contaminant flow that causes them. This work will also help to demonstrate the feasibility or value of doing lab experiments in imaging that can be applied to interpreting field-scale experiments. A secondary objective of this study was to initiate a collaboration with researchers at the Rensselaer Polytechnic Institute (RPI; Troyl NY) who are also participants in the newly created NSF Center for Subsurface Imaging and Sensing Systems (CenSSIS) which is managed in part by RPI. During the course of this study C.R. Carrigan and W. Daily visited the electromagnetic imaging lab at RPI to initiate discussions on subsurface imaging technology with Professors David Isaacson, Jon Newell, Gary Salunier and their research graduate students. A major goal of CenSSIS is to promote collaborations among researchers with imaging backgrounds in different disciplines (geosciences, biomedical, civil engineering and biomedical) that will lead to new solutions of common subsurface imaging problems. The geophysical test section constructed for this study included electrode arrays that resemble biomedical array distributions. Comparing images of the same target produced with the 4-array geophysical approach and with the biomedical imaging approach will help us to better understand differences and advantages that are characteristic of the two imaging methods. Our initial interactions with the researchers at RPI concluded that this was a viable problem to consider. The support for this subsequent research will come from a 3-year Office of Basic Energy Sciences (BES) proposal that has just received funding. This feasibility study contributed positively to the successful review and ultimately to the award of this BES funding. A letter (Appendix) from Professor Michael Silevitch, Director of CenSSIS, to Dr. Rokaya Al-Ayat, Director of the LLNL Science & Technology Office, acknowledges the contribution of this LDRD study to obtaining the Basic Energy Science grant that will fund further work in this area.« less

Tomography images of the Alpine roots and surrounding upper mantle

NASA Astrophysics Data System (ADS)

Plomerova, Jaroslava; Babuska, Vladislav

2017-04-01

Teleseismic body-wave tomography represents powerful tool to study regional velocity structure of the upper mantle and to image velocity anomalies, such as subducted lithosphere plates in collisional zones. In this contribution, we recapitulate 3D models of the upper mantle beneath the Alps, which developed at a collision zone of the Eurasian and African plates. Seismic tomography studies indicate a leading role of the rigid mantle lithosphere that functioned as a major stress guide during the plate collisions. Interactions of the European lithosphere with several micro-plates in the south resulted in an arcuate shape of this mountain range on the surface and in a complicated geometry of the Alpine subductions in the mantle. Early models with one bended lithosphere root have been replaced with more advanced models showing two separate lithosphere roots beneath the Western and Eastern Alps (Babuska et al., Tectonophysics 1990; Lippitsch et al., JGR 2003). The standard isotropic velocity tomography, based on pre-AlpArray data (the currently performed passive seismic experiment in the Alps and surroundings) images the south-eastward dipping curved slab of the Eurasian lithosphere in the Western Alps. On the contrary, beneath the Eastern Alps the results indicate a very steep northward dipping root that resulted from the collision of the European plate with the Adriatic microplate. Dando et al. (2011) interpret high-velocity heterogeneities at the bottom of their regional tomographic model as a graveyard of old subducted lithospheres. High density of stations, large amount of rays and dense ray-coverage of the volume studied are not the only essential pre-requisites for reliable tomography results. A compromise between the amount of pre-processed data and the high-quality of the tomography input (travel-time residuals) is of the high importance as well. For the first time, the existence of two separate roots beneath the Alps has been revealed from carefully pre-processed, mostly the ISC-bulletin data (Babuska et al., Tectonophysics 1990). Calculated relative travel-time residuals have been assigned to source clusters and filtered relative to the residual mean of each cluster of events. We expect that future 3D studies of the mantle velocities and mantle fabrics with the use of body-wave anisotropic parameters from the AlpArray data will shed a new light on tectonic development of the complex Alpine region and its surroundings.

Seismic imaging: From classical to adjoint tomography

NASA Astrophysics Data System (ADS)

Liu, Q.; Gu, Y. J.

2012-09-01

Seismic tomography has been a vital tool in probing the Earth's internal structure and enhancing our knowledge of dynamical processes in the Earth's crust and mantle. While various tomographic techniques differ in data types utilized (e.g., body vs. surface waves), data sensitivity (ray vs. finite-frequency approximations), and choices of model parameterization and regularization, most global mantle tomographic models agree well at long wavelengths, owing to the presence and typical dimensions of cold subducted oceanic lithospheres and hot, ascending mantle plumes (e.g., in central Pacific and Africa). Structures at relatively small length scales remain controversial, though, as will be discussed in this paper, they are becoming increasingly resolvable with the fast expanding global and regional seismic networks and improved forward modeling and inversion techniques. This review paper aims to provide an overview of classical tomography methods, key debates pertaining to the resolution of mantle tomographic models, as well as to highlight recent theoretical and computational advances in forward-modeling methods that spearheaded the developments in accurate computation of sensitivity kernels and adjoint tomography. The first part of the paper is devoted to traditional traveltime and waveform tomography. While these approaches established a firm foundation for global and regional seismic tomography, data coverage and the use of approximate sensitivity kernels remained as key limiting factors in the resolution of the targeted structures. In comparison to classical tomography, adjoint tomography takes advantage of full 3D numerical simulations in forward modeling and, in many ways, revolutionizes the seismic imaging of heterogeneous structures with strong velocity contrasts. For this reason, this review provides details of the implementation, resolution and potential challenges of adjoint tomography. Further discussions of techniques that are presently popular in seismic array analysis, such as noise correlation functions, receiver functions, inverse scattering imaging, and the adaptation of adjoint tomography to these different datasets highlight the promising future of seismic tomography.

The Capricorn Orogen Passive source Array (COPA) in Western Australia

NASA Astrophysics Data System (ADS)

Gessner, K.; Yuan, H.; Murdie, R.; Dentith, M. C.; Johnson, S.; Brett, J.

2015-12-01

COPA is the passive source component of a multi-method geophysical program aimed at assessing the mineral deposits potential of the Proterozoic Capricorn Orogen. Previous results from the active source surveys, receiver functions and magnetotelluric studies show reworked orogenic crust in the orogen that contrasts with more simple crust in the neighbouring Archean cratons, suggesting progressive and punctuated collisional processes during the final amalgamation of the Western Australian craton. Previous seismic studies are all based on line deployment or single station analyses; therefore it is essential to develop 3D seismic images to test whether these observations are representative for the whole orogen. With a careful design that takes advantage of previous passive source surveys, the current long-term and short-term deployments span an area of approximately 500 x 500 km. The 36-month total deployment can guarantee enough data recording for 3D structure imaging using body wave tomography, ambient noise surface wave tomography and P- and S-wave receiver function Common Conversion Point (CCP) stacking techniques. A successive instrument loan from the ANSIR national instrument pool, provided 34 broadband seismometers that have been deployed in the western half of the orogen since March 2014. We expect approximately 40-km lateral resolution near the surface for the techniques we propose, which due to low frequency nature of earthquake waves will degrade to about 100 km near the base of the cratonic lithosphere, which is expected at depths between 200 to 250 km. Preliminary results from the first half of the COPA deployment will be presented in the light of the hypotheses that 1) distinct crustal blocks can be detected continuously throughout the orogen (using ambient noise/body wave tomography); 2) distinct lithologies are present in the crust and upper mantle across the orogen (using receiver function CCP images); and 3) crustal and lithosphere deformation along craton margins in general follows the "wedge" tectonic model (e.g. subduction of Juvenile blocks under the craton mantle as represented by craton-ward dipping sutures.

A comparison of two mobile electrode arrays for increasing mortality of Lake Trout embryos

USGS Publications Warehouse

Brown, Peter J.; Guy, Christopher S.; Meeuwig, Michael H.

2017-01-01

Conservation of sport fisheries and populations of several native fishes in the western United States is dependent on sustained success of removal programs targeting invasive Lake Trout Salvelinus namaycush. Gill-netting of spawning adults is one strategy used to decrease spawning success; however, additional complementary methods are needed to disrupt Lake Trout reproduction where bycatch in gill nets is unacceptable. We developed and tested two portable electrode arrays designed to increase Lake Trout embryo mortality in known spawning areas. Both arrays were powered by existing commercial electrofishing equipment. However, one array was moved across the substrate to simulate being towed behind a boat (i.e., towed array), while the other array was lowered from a boat and energized when sedentary (i.e., sedentary array). The arrays were tested on embryos placed within substrates of known spawning areas. Both arrays increased mortality of embryos (>90%) at the surface of substrates, but only the sedentary array was able to increase mortality to >90% at deeper burial depths. In contrast, embryos at increasingly deeper depths exhibited progressively lower mortality when exposed to the towed array. Mortality of embryos placed under 20 cm of substrate and exposed to the towed array was not significantly different from that of unexposed embryos in a control group. We suggest that the sedentary array could be used as a viable approach for increasing mortality of Lake Trout embryos buried to 20 cm and that it could be modified to be effective at deeper depths.

APPLICATION OF 3D COMPUTER-AIDED TOMOGRAPHY TO THE QUANTIFICATION OF MARINE SEDIMENT COMMUNITIES IN POLLUTION GRADIENTS

EPA Science Inventory

Computer-Aided Tomography (CT) has been demonstrated to be a cost efficient tool for the qualitative and quantitative study of estuarine benthic communities along pollution gradients.
Now we have advanced this technology to successfully visualize and discriminate three dimen...

Seven-panel solar wing deployment and on-orbit maneuvering analyses

NASA Astrophysics Data System (ADS)

Hwang, Earl

2005-05-01

BSS developed a new generation high power (~20kW) solar array to meet the customer demands. The high power solar array had the north and south solar wings of which designs were identical. Each side of the solar wing consists of three main conventional solar panels and the four-side panel swing-out new design. The fully deployed solar array surface area is 966 ft2. It was a quite challenging task to define the solar array's optimum design parameters and deployment scheme for such a huge solar array's successful deployment and on-orbit maneuvering. Hence, a deployable seven-flex-panel solar wing nonlinear math model and a fully deployed solar array/bus-payload math model were developed with the Dynamic Analysis and Design System (DADS) program codes utilizing the inherited and empirical data. Performing extensive parametric analyses with the math model, the optimum design parameters and the orbit maneuvering /deployment schemes were determined to meet all the design requirements, and for the successful solar wing deployment on-orbit.

SCARLET I: Mechanization solutions for deployable concentrator optics integrated with rigid array technology

NASA Technical Reports Server (NTRS)

Wachholz, James J.; Murphy, David M.

1996-01-01

The SCARLET I (Solar Concentrator Army with Refractive Linear Element Technology) solar array wing was designed and built to demonstrate, in flight, the feasibility of integrating deployable concentrator optics within the design envelope of typical rigid array technology. Innovative mechanism designs were used throughout the array, and a full series of qualification tests were successfully performed in anticipation of a flight on the Multiple Experiment Transporter to Earth Orbit and Return (METEOR) spacecraft. Even though the Conestoga launch vehicle was unable to place the spacecraft in orbit, the program effort was successful in achieving the milestones of analytical and design development functional validation, and flight qualification, thus leading to a future flight evaluation for the SCARLET technology.

Strikingly enhanced cooling performance for a micro-cooler using unique Cu nanowire array with high electrical conductivity and fast heat transfer behavior

NASA Astrophysics Data System (ADS)

Tan, Ming; Wang, Xiuzhen; Hao, Yanming; Deng, Yuan

2017-06-01

It was found that phonons/electrons are less scattered along (1 1 1)-preferred Cu nanowires than in ordinary structure films and that the interface of Cu nanowires electrode and thermoelectric materials are more compatible. Here highly ordered, high-crystal-quality, high-density Cu nanowire array was successfully fabricated by a magnetron sputtering method. The Cu nanowire array was successfully incorporated using mask-assisted deposition technology as electrodes for thin-film thermoelectric coolers, which would greatly improve electrical/thermal transport and enhance performance of micro-coolers. The cooling performance of the micro-cooler with Cu nanowire array electrode is over 200% higher than that of the cooler with ordinary film electrode.

Integrated microelectrode array and microfluidics for temperature clamp of sensory neurons in culture.

PubMed

Pearce, Thomas M; Wilson, J Adam; Oakes, S George; Chiu, Shing-Yan; Williams, Justin C

2005-01-01

A device for cell culture is presented that combines MEMS technology and liquid-phase photolithography to create a microfluidic chip that influences and records electrical cellular activity. A photopolymer channel network is formed on top of a multichannel microelectrode array. Preliminary results indicated successful local thermal control within microfluidic channels and control of lamina position over the electrode array. To demonstrate the biological application of such a device, adult dissociated dorsal root ganglion neurons with a subpopulation of thermally-sensitive cells are attached onto the electrode array. Using laminar flow, dynamic control of local temperature of the neural cells was achieved while maintaining a constant chemical culture medium. Recording the expected altered cellular activity confirms the success of the integrated device.

SCARLET I: Mechanization solutions for deployable concentrator optics integrated with rigid array technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wachholz, J.J.; Murphy, D.M.

1996-05-01

The SCARLET I (Solar Concentrator Army with Refractive Linear Element Technology) solar array wing was designed and built to demonstrate, in flight, the feasibility of integrating deployable concentrator optics within the design envelope of typical rigid array technology. Innovative mechanism designs were used throughout the array, and a full series of qualification tests were successfully performed in anticipation of a flight on the Multiple Experiment Transporter to Earth Orbit and Return (METEOR) spacecraft. Even though the Conestoga launch vehicle was unable to place the spacecraft in orbit, the program effort was successful in achieving the milestones of analytical and designmore » development functional validation, and flight qualification, thus leading to a future flight evaluation for the SCARLET technology.« less

A Review of In-Office Dynamic Image Navigation for Extraction of Complex Mandibular Third Molars.

PubMed

Emery, Robert W; Korj, Oxana; Agarwal, Ravi

2017-08-01

We performed a retrospective review of in-office removal of complex mandibular third molars with a dynamic image navigation system (DINS). A retrospective review was conducted of cases completed from 2010 to 2014 by a single oral and maxillofacial surgeon. The average age of the patients was 47 years (range, 27 to 72 years). Extraction complexity was classified with Juodzbalys and Daugela's classification system. The included study cases had complexity scores of 9 or greater. Each patient received custom intraoral splints to secure the tracking array and underwent cone beam computed tomography image acquisition. All surgical procedures were performed with a precalibrated tracking straight handpiece under dynamic navigation. All 25 cases were treated successfully with the use of the DINS. Twelve of these cases were associated with pathologic lesions. Three patients were noted to have inferior alveolar nerve paresthesia. One patient sustained a pathologic fracture at week 2. Postoperative infections were noted in 7 cases, 2 of which had a pre-existing infection. One patient reported temporary limitation of mouth opening. A coronectomy was performed in 1 case. We present results using a new technology, the DINS, for removal of complex mandibular third molars. Potential advantages are 1) improved visualization and localization of anatomic structures such as the inferior alveolar nerve, lingual cortical plate, and adjacent roots; 2) improved control during osteotomy; 3) decreased surgical access requirements and reduction in overall bone removal; 4) ability to perform complex procedures successfully in an in-office setting; 5) decreased surgical time resulting from improved visualization; and 6) potential use as a teaching tool. Possible limitations of the use of an in-office DINS include increased cost, increased time attributed to presurgical planning, initial learning curve, and optical array interference by the surgeon or assistants during surgery. Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

A multichannel scala tympani electrode array incorporating a drug delivery system for chronic intracochlear infusion.

PubMed

Shepherd, Robert K; Xu, Jin

2002-10-01

We have developed a novel scala tympani electrode array suitable for use in experimental animals. A unique feature of this array is its ability to chronically deliver pharmacological agents to the scala tympani. The design of the electrode array is described in detail. Experimental studies performed in guinea pigs confirm that this array can successfully deliver various drugs to the cochlea while chronically stimulating the auditory nerve.

Tomography of the upper mantle beneath the African/Iberian collision zone

NASA Astrophysics Data System (ADS)

Bonnin, Mickael; Nolet, Guust; Thomas, Christine; Villaseñor, Antonio; Gallart, Josep; Levander, Alan

2013-04-01

In this study we take advantage of the dense broadband-station networks available in western Mediterranean region (IberArray, PICASSO and MOROCCO-MUENSTER networks) to develop a high-resolution 3D tomographic P velocity model of the upper mantle beneath the African/Iberian collision zone. This model is based on teleseismic arrival times recorded between 2008 and 2012 for which cross-correlation delays are measured with a new technique in different frequency bands centered between 0.03 and 1.0 Hz, and interpreted using multiple frequency tomography. Such a tomography is required to scrutinize the nature and extent of the thermal anomalies inferred beneath Northern Africa, especially in the Atlas ranges region and associated to sparse volcanic activities. Tomography is notably needed to help in determining the hypothetical connection between those hot anomalies and the Canary Island hotspot as proposed by geochemistry studies. It also provides new insights on the geometry of the subducting slab previously inferred from tomography, GPS measurements or shear-wave splitting patterns beneath the Alboran Sea and the Betic ranges and is indispensable for deciphering the complex geodynamic history of the Western Mediterranean region. We shall present the overall statistics of the delays, their geographical distribution, as well as the first inversion results.

Determination of the Pressure Equivalent Noise Signal of Vector Sensors in a Hybrid Array

DTIC Science & Technology

2012-12-01

pressure sensors for acoustic signals raises the possibility of increased sonar array performance with smaller arrays. Caulk successfully...contribution of the preamplifier in the circuit was estimated as . So the Johnson noise of the sensor wires themselves is expected to dominate

High resolution scintillation detector with semiconductor readout

DOEpatents

Levin, Craig S.; Hoffman, Edward J.

2000-01-01

A novel high resolution scintillation detector array for use in radiation imaging such as high resolution Positron Emission Tomography (PET) which comprises one or more parallelepiped crystals with at least one long surface of each crystal being in intimate contact with a semiconductor photodetector such that photons generated within each crystal by gamma radiation passing therethrough is detected by the photodetector paired therewith.

Dual-foci detection in photoacoustic computed tomography with coplanar light illumination and acoustic detection: a phantom study.

PubMed

Lin, Xiangwei; Liu, Chengbo; Meng, Jing; Gong, Xiaojing; Lin, Riqiang; Sun, Mingjian; Song, Liang

2018-05-01

A dual-foci transducer with coplanar light illumination and acoustic detection was applied for the first time. It overcame the small directivity angle, low-sensitivity, and large datasets in conventional circular scanning or array-based photoacoustic computed tomography (PACT). The custom-designed transducer is focused on both the scanning plane with virtual-point detection and the elevation direction for large field of view (FOV) cross-sectional imaging. Moreover, a coplanar light illumination and acoustic detection configuration can provide ring-shaped light irradiation with highly efficient acoustic detection, which in principle has a better adaptability when imaging samples of irregular surfaces. Phantom experiments showed that our PACT system can achieve high resolution (∼0.5  mm), enhanced signal-to-noise ratio (16-dB improvement), and a more complete structure in a greater FOV with an equal number of sampling points compared with the results from a flat aperture transducer. This study provides the proof of concept for the fabrication of a sparse array with the dual-foci property and large aperture size for high-quality, low-cost, and high-speed photoacoustic imaging. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

Neutron imaging with lithium indium diselenide: Surface properties, spatial resolution, and computed tomography

NASA Astrophysics Data System (ADS)

Lukosi, Eric D.; Herrera, Elan H.; Hamm, Daniel S.; Burger, Arnold; Stowe, Ashley C.

2017-11-01

An array of lithium indium diselenide (LISe) scintillators were investigated for application in neutron imaging. The sensors, varying in thickness and surface roughness, were tested using both reflective and anti-reflective mounting to an aluminum window. The spatial resolution of each LISe scintillator was calculated using the knife-edge test and a modulation transfer function analysis. It was found that the anti-reflective backing case yielded higher spatial resolutions by up to a factor of two over the reflective backing case despite a reduction in measured light yield by an average of 1.97. In most cases, the use of an anti-reflective backing resulted in a higher spatial resolution than the 50 μm-thick ZnS(Cu):6 LiF comparison scintillation screen. The effect of surface roughness was not directly correlated to measured light yield or observed spatial resolution, but weighting the reflective backing case by the random surface roughness revealed that a linear relationship exists between the fractional change (RB/ARB) of the two. Finally, the LISe scintillator array was used in neutron computed tomography to investigate the features of halyomorpha halys with the reflective and anti-reflective backing.

Adapting Controlled-source Coherence Analysis to Dense Array Data in Earthquake Seismology

NASA Astrophysics Data System (ADS)

Schwarz, B.; Sigloch, K.; Nissen-Meyer, T.

2017-12-01

Exploration seismology deals with highly coherent wave fields generated by repeatable controlled sources and recorded by dense receiver arrays, whose geometry is tailored to back-scattered energy normally neglected in earthquake seismology. Owing to these favorable conditions, stacking and coherence analysis are routinely employed to suppress incoherent noise and regularize the data, thereby strongly contributing to the success of subsequent processing steps, including migration for the imaging of back-scattering interfaces or waveform tomography for the inversion of velocity structure. Attempts have been made to utilize wave field coherence on the length scales of passive-source seismology, e.g. for the imaging of transition-zone discontinuities or the core-mantle-boundary using reflected precursors. Results are however often deteriorated due to the sparse station coverage and interference of faint back-scattered with transmitted phases. USArray sampled wave fields generated by earthquake sources at an unprecedented density and similar array deployments are ongoing or planned in Alaska, the Alps and Canada. This makes the local coherence of earthquake data an increasingly valuable resource to exploit.Building on the experience in controlled-source surveys, we aim to extend the well-established concept of beam-forming to the richer toolbox that is nowadays used in seismic exploration. We suggest adapted strategies for local data coherence analysis, where summation is performed with operators that extract the local slope and curvature of wave fronts emerging at the receiver array. Besides estimating wave front properties, we demonstrate that the inherent data summation can also be used to generate virtual station responses at intermediate locations where no actual deployment was performed. Owing to the fact that stacking acts as a directional filter, interfering coherent wave fields can be efficiently separated from each other by means of coherent subtraction. We propose to construct exploration-type trace gathers, systematically investigate the potential to improve the quality and regularity of realistic synthetic earthquake data and present attempts at separating transmitted and back-scattered wave fields for the improved imaging of Earth's large-scale discontinuities.

Initial clinical evaluation of stationary digital chest tomosynthesis

NASA Astrophysics Data System (ADS)

Hartman, Allison E.; Shan, Jing; Wu, Gongting; Lee, Yueh Z.; Zhou, Otto; Lu, Jianping; Heath, Michael; Wang, Xiaohui; Foos, David

2016-03-01

Computed Tomography (CT) is the gold standard for image evaluation of lung disease, including lung cancer and cystic fibrosis. It provides detailed information of the lung anatomy and lesions, but at a relatively high cost and high dose of radiation. Chest radiography is a low dose imaging modality but it has low sensitivity. Digital chest tomosynthesis (DCT) is an imaging modality that produces 3D images by collecting x-ray projection images over a limited angle. DCT is less expensive than CT and requires about 1/10th the dose of radiation. Commercial DCT systems acquire the projection images by mechanically scanning an x-ray tube. The movement of the tube head limits acquisition speed. We recently demonstrated the feasibility of stationary digital chest tomosynthesis (s-DCT) using a carbon nanotube (CNT) x-ray source array in benchtop phantom studies. The stationary x-ray source allows for fast image acquisition. The objective of this study is to demonstrate the feasibility of s-DCT for patient imaging. We have successfully imaged 31 patients. Preliminary evaluation by board certified radiologists suggests good depiction of thoracic anatomy and pathology.

Operational considerations of the Advanced Photovoltaic Solar Array

NASA Technical Reports Server (NTRS)

Stella, Paul M.; Kurland, Richard M.

1992-01-01

Issues affecting the long-term operational performance of the Advanced Photovoltaic Solar Array (APSA) are discussed, with particular attention given to circuit electrical integrity from shadowed and cracked cell modules. The successful integration of individual advanced array components provides a doubling of array specific performance from the previous NASA-developed advanced array (SAFE). Flight test modules both recently fabricated and under fabrication are described. The development of advanced high-performance blanket technology for future APSA enhancement is presented.

Operational considerations of the Advanced Photovoltaic Solar Array

NASA Astrophysics Data System (ADS)

Stella, Paul M.; Kurland, Richard M.

Issues affecting the long-term operational performance of the Advanced Photovoltaic Solar Array (APSA) are discussed, with particular attention given to circuit electrical integrity from shadowed and cracked cell modules. The successful integration of individual advanced array components provides a doubling of array specific performance from the previous NASA-developed advanced array (SAFE). Flight test modules both recently fabricated and under fabrication are described. The development of advanced high-performance blanket technology for future APSA enhancement is presented.

Use of Computed Tomography Imaging for Qualifying Coarse Roots, Rhizomes, Peat, and Particle Densities in Marsh Soils

EPA Science Inventory

Computed tomography (CT) imaging has been used to describe and quantify subtidal, benthic animals such as polychaetes, amphipods, and shrimp. Here, for the first time, CT imaging is used to successfully quantify wet mass of coarse roots, rhizomes, and peat in cores collected from...

Positron emission tomography/computed tomography in melanoma.

PubMed

Bourgeois, Austin C; Chang, Ted T; Fish, Lindsay M; Bradley, Yong C

2013-09-01

Fludeoxyglucose F 18 positron emission tomography/computed tomography (PET/CT) has been invaluable in the assessment of melanoma throughout the course of the disease. As with any modality, the studies are incomplete and more information will be gleaned as our experience progresses. Additionally, it is hoped that a newer PET agent in the pipeline will give us even greater success in the identification and subsequent treatment of melanoma. This article aims to examine the utilization of PET/CT in the staging, prognostication, and follow-up of melanoma while providing the physicians who order and interpret these studies practical guidelines and interpretive pitfalls. Copyright © 2013 Elsevier Inc. All rights reserved.

Space Environment Testing of Photovoltaic Array Systems

NASA Technical Reports Server (NTRS)

Phillips, Brandon; Schneider, Todd A.; Vaughn, Jason A.; Wright, Kenneth H.

2015-01-01

To successfully operate a photovoltaic (PV) array system in space requires planning and testing to account for the effects of the space environment. It is critical to understand space environment interactions not only on the PV components, but also the array substrate materials, wiring harnesses, connectors, and protection circuitry.

Structure and assembly of a paramyxovirus matrix protein

PubMed Central

Battisti, Anthony J.; Meng, Geng; Winkler, Dennis C.; McGinnes, Lori W.; Plevka, Pavel; Steven, Alasdair C.; Morrison, Trudy G.; Rossmann, Michael G.

2012-01-01

Many pleomorphic, lipid-enveloped viruses encode matrix proteins that direct their assembly and budding, but the mechanism of this process is unclear. We have combined X-ray crystallography and cryoelectron tomography to show that the matrix protein of Newcastle disease virus, a paramyxovirus and relative of measles virus, forms dimers that assemble into pseudotetrameric arrays that generate the membrane curvature necessary for virus budding. We show that the glycoproteins are anchored in the gaps between the matrix proteins and that the helical nucleocapsids are associated in register with the matrix arrays. About 90% of virions lack matrix arrays, suggesting that, in agreement with previous biological observations, the matrix protein needs to dissociate from the viral membrane during maturation, as is required for fusion and release of the nucleocapsid into the host’s cytoplasm. Structure and sequence conservation imply that other paramyxovirus matrix proteins function similarly. PMID:22891297

Structure and assembly of a paramyxovirus matrix protein.

PubMed

Battisti, Anthony J; Meng, Geng; Winkler, Dennis C; McGinnes, Lori W; Plevka, Pavel; Steven, Alasdair C; Morrison, Trudy G; Rossmann, Michael G

2012-08-28

Many pleomorphic, lipid-enveloped viruses encode matrix proteins that direct their assembly and budding, but the mechanism of this process is unclear. We have combined X-ray crystallography and cryoelectron tomography to show that the matrix protein of Newcastle disease virus, a paramyxovirus and relative of measles virus, forms dimers that assemble into pseudotetrameric arrays that generate the membrane curvature necessary for virus budding. We show that the glycoproteins are anchored in the gaps between the matrix proteins and that the helical nucleocapsids are associated in register with the matrix arrays. About 90% of virions lack matrix arrays, suggesting that, in agreement with previous biological observations, the matrix protein needs to dissociate from the viral membrane during maturation, as is required for fusion and release of the nucleocapsid into the host's cytoplasm. Structure and sequence conservation imply that other paramyxovirus matrix proteins function similarly.

Ultrasonic guided wave tomography of pipes: A development of new techniques for the nondestructive evaluation of cylindrical geometries and guided wave multi-mode analysis

NASA Astrophysics Data System (ADS)

Leonard, Kevin Raymond

This dissertation concentrates on the development of two new tomographic techniques that enable wide-area inspection of pipe-like structures. By envisioning a pipe as a plate wrapped around upon itself, the previous Lamb Wave Tomography (LWT) techniques are adapted to cylindrical structures. Helical Ultrasound Tomography (HUT) uses Lamb-like guided wave modes transmitted and received by two circumferential arrays in a single crosshole geometry. Meridional Ultrasound Tomography (MUT) creates the same crosshole geometry with a linear array of transducers along the axis of the cylinder. However, even though these new scanning geometries are similar to plates, additional complexities arise because they are cylindrical structures. First, because it is a single crosshole geometry, the wave vector coverage is poorer than in the full LWT system. Second, since waves can travel in both directions around the circumference of the pipe, modes can also constructively and destructively interfere with each other. These complexities necessitate improved signal processing algorithms to produce accurate and unambiguous tomographic reconstructions. Consequently, this work also describes a new algorithm for improving the extraction of multi-mode arrivals from guided wave signals. Previous work has relied solely on the first arriving mode for the time-of-flight measurements. In order to improve the LWT, HUT and MUT systems reconstructions, improved signal processing methods are needed to extract information about the arrival times of the later arriving modes. Because each mode has different through-thickness displacement values, they are sensitive to different types of flaws, and the information gained from the multi-mode analysis improves understanding of the structural integrity of the inspected material. Both tomographic frequency compounding and mode sorting algorithms are introduced. It is also shown that each of these methods improve the reconstructed images both qualitatively and quantitatively.

SU-G-JeP1-01: A Combination of Real Time Electromagnetic Localization and Tracking with Cone Beam Computed Tomography in Stereotactic Radiosurgery for Brain Tumors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muralidhar, K Raja; Pangam, Suresh; Ponaganti, Srinivas

2016-06-15

Purpose: 1. online verification of patient position during treatment using calypso electromagnetic localization and tracking system. 2. Verification and comparison of positional accuracy between cone beam computed tomography and calypso system. 3. Presenting the advantage of continuation localization in Stereotactic radiosurgery treatments. Methods: Ten brain tumor cases were taken for this study. Patients with head mask were under gone Computed Tomography (CT). Before scanning, mask was cut on the fore head area to keep surface beacons on the skin. Slice thickness of 0.65 mm were taken for this study. x, y, z coordinates of these beacons in TPS were enteredmore » into tracking station. Varian True Beam accelerator, equipped with On Board Imager was used to take Cone beam Computed Tomography (CBCT) to localize the patient. Simultaneously Surface beacons were used to localize and track the patient throughout the treatment. The localization values were compared in both systems. For localization CBCT considered as reference. Tracking was done throughout the treatment using Calypso tracking system using electromagnetic array. This array was in tracking position during imaging and treatment. Flattening Filter free beams of 6MV photons along with Volumetric Modulated Arc Therapy was used for the treatment. The patient movement was observed throughout the treatment ranging from 2 min to 4 min. Results: The average variation observed between calypso system and CBCT localization was less than 0.5 mm. These variations were due to manual errors while keeping beacon on the patient. Less than 0.05 cm intra-fraction motion was observed throughout the treatment with the help of continuous tracking. Conclusion: Calypso target localization system is one of the finest tools to perform radiosurgery in combination with CBCT. This non radiographic method of tracking is a real beneficial method to treat patients confidently while observing real-time motion information of the patient.« less

Stressed detector arrays for airborne astronomy

NASA Technical Reports Server (NTRS)

Stacey, G. J.; Beeman, J. W.; Haller, E. E.; Geis, N.; Poglitsch, A.; Rumitz, M.

1989-01-01

The development of stressed Ge:Ga detector arrays for far-infrared astronomy from the Kuiper Airborne Observatory (KAO) is discussed. Researchers successfully constructed and used a three channel detector array on five flights from the KAO, and have conducted laboratory tests of a two-dimensional, 25 elements (5x5) detector array. Each element of the three element array performs as well as the researchers' best single channel detector, as do the tested elements of the 25 channel system. Some of the exciting new science possible with far-infrared detector arrays is also discussed.

Crustal Structure in the Western Part of Romania from Local Seismic Tomography

NASA Astrophysics Data System (ADS)

Zaharia, Bogdan; Grecu, Bogdan; Popa, Mihaela; Oros, Eugen; Radulian, Mircea

2017-12-01

The inner part of the Carpathians in Romania belongs to the Carpathians-Pannonian system bordered by the Eastern Carpathians to the north and east, Southern Carpathians to the south and Pannonian Basin to the west. It is a complex tectonic region with differential folding mechanisms, post-collisional kinematics, rheology and thermal properties, including within its area the Apuseni Mountains and the Transylvanian Basin. The purpose of this study is to map the 3-D structure of the crust over this region on the basis of local earthquake data. Input data were recorded during the South Carpathian Project (2009-2011), a successful collaboration between the Institute of Geophysics and Tectonics of the University of Leeds and the National Institute for Earth Physics (NIEP), Romania. A temporary array of 32 broadband seismic stations (10 CMG-40T, 8 CMG-3T and 14 CMG-6TD) was installed across the western part of Romania (spaced at 40 to 50 km intervals) during the project. In addition, 25 stations deployed in the eastern Hungary and Serbia was considered. P- and S-wave arrivals are identified for all the selected events (minimum 7 phases per event with reasonable signal/noise ratio). All the events are first relocated using Joint Hypocentre Determination (JHD) technique. Then the well-located events were inverted to determine the crustal structure using LOTOS algorithm. The lateral variations of the crustal properties as resulted from the tomography image are interpreted in correlation with the station corrections estimated by JHD algorithm and with the post-collisional evolution of the Carpathians-Pannonian system.

Degradation of metallic materials studied by correlative tomography

NASA Astrophysics Data System (ADS)

Burnett, T. L.; Holroyd, N. J. H.; Lewandowski, J. J.; Ogurreck, M.; Rau, C.; Kelley, R.; Pickering, E. J.; Daly, M.; Sherry, A. H.; Pawar, S.; Slater, T. J. A.; Withers, P. J.

2017-07-01

There are a huge array of characterization techniques available today and increasingly powerful computing resources allowing for the effective analysis and modelling of large datasets. However, each experimental and modelling tool only spans limited time and length scales. Correlative tomography can be thought of as the extension of correlative microscopy into three dimensions connecting different techniques, each providing different types of information, or covering different time or length scales. Here the focus is on the linking of time lapse X-ray computed tomography (CT) and serial section electron tomography using the focussed ion beam (FIB)-scanning electron microscope to study the degradation of metals. Correlative tomography can provide new levels of detail by delivering a multiscale 3D picture of key regions of interest. Specifically, the Xe+ Plasma FIB is used as an enabling tool for large-volume high-resolution serial sectioning of materials, and also as a tool for preparation of microscale test samples and samples for nanoscale X-ray CT imaging. The exemplars presented illustrate general aspects relating to correlative workflows, as well as to the time-lapse characterisation of metal microstructures during various failure mechanisms, including ductile fracture of steel and the corrosion of aluminium and magnesium alloys. Correlative tomography is already providing significant insights into materials behaviour, linking together information from different instruments across different scales. Multiscale and multifaceted work flows will become increasingly routine, providing a feed into multiscale materials models as well as illuminating other areas, particularly where hierarchical structures are of interest.

Optical Communications With A Geiger Mode APD Array

DTIC Science & Technology

2016-02-09

spurious fires from numerous sources, including crosstalk from other detectors in the same array . Additionally, after a 9 successful detection, the...be combined into arrays with large numbers of detectors , allowing for scaling of dynamic range with relatively little overhead on space and power...overall higher rate of dark counts than a single detector , this is more than compensated for by the extra detectors . A sufficiently large APD array could

Evaluating the scattered radiation intensity in CBCT

NASA Astrophysics Data System (ADS)

Gonçalves, O. D.; Boldt, S.; Nadaes, M.; Devito, K. L.

2018-03-01

In this work we calculate the ratio between scattered and transmitted photons (STRR) by a water cylinder reaching a detector matrix element (DME) in a flat array of detectors, similar to the used in cone beam tomography (CBCT), as a function of the field of view (FOV) and the irradiated volume of the scanned object. We perform the calculation by obtaining an equation to determine the scattered and transmitted radiation and building a computer code in order to calculate the contribution of all voxels of the sample. We compare calculated results with the shades of gray in a central slice of a tomography obtained from a cylindrical glass container filled with distilled water. The tomography was performed with an I-CAT tomograph (Imaging Science International), from the Department of Dental Clinic - Oral Radiology, Universidade Federal de Juiz de Fora. The shade of gray (voxel gray value - VGV) was obtained using the software provided with the I-CAT. The experimental results show a general behavior compatible with theoretical previsions attesting the validity of the method used to calculate the scattering contributions from simple scattering theories in cone beam tomography. The results also attest to the impossibility of obtaining Hounsfield values from a CBCT.

3D parallel-detection microwave tomography for clinical breast imaging

PubMed Central

Meaney, P. M.; Paulsen, K. D.

2014-01-01

A biomedical microwave tomography system with 3D-imaging capabilities has been constructed and translated to the clinic. Updates to the hardware and reconfiguration of the electronic-network layouts in a more compartmentalized construct have streamlined system packaging. Upgrades to the data acquisition and microwave components have increased data-acquisition speeds and improved system performance. By incorporating analog-to-digital boards that accommodate the linear amplification and dynamic-range coverage our system requires, a complete set of data (for a fixed array position at a single frequency) is now acquired in 5.8 s. Replacement of key components (e.g., switches and power dividers) by devices with improved operational bandwidths has enhanced system response over a wider frequency range. High-integrity, low-power signals are routinely measured down to −130 dBm for frequencies ranging from 500 to 2300 MHz. Adequate inter-channel isolation has been maintained, and a dynamic range >110 dB has been achieved for the full operating frequency range (500–2900 MHz). For our primary band of interest, the associated measurement deviations are less than 0.33% and 0.5° for signal amplitude and phase values, respectively. A modified monopole antenna array (composed of two interwoven eight-element sub-arrays), in conjunction with an updated motion-control system capable of independently moving the sub-arrays to various in-plane and cross-plane positions within the illumination chamber, has been configured in the new design for full volumetric data acquisition. Signal-to-noise ratios (SNRs) are more than adequate for all transmit/receive antenna pairs over the full frequency range and for the variety of in-plane and cross-plane configurations. For proximal receivers, in-plane SNRs greater than 80 dB are observed up to 2900 MHz, while cross-plane SNRs greater than 80 dB are seen for 6 cm sub-array spacing (for frequencies up to 1500 MHz). We demonstrate accurate recovery of 3D dielectric property distributions for breast-like phantoms with tumor inclusions utilizing both the in-plane and new cross-plane data. PMID:25554311

Usefulness of Cone-Beam Computed Tomography and Automatic Vessel Detection Software in Emergency Transarterial Embolization.

PubMed

Carrafiello, Gianpaolo; Ierardi, Anna Maria; Duka, Ejona; Radaelli, Alessandro; Floridi, Chiara; Bacuzzi, Alessandro; de Bucourt, Maximilian; De Marchi, Giuseppe

2016-04-01

This study was designed to evaluate the utility of dual phase cone beam computed tomography (DP-CBCT) and automatic vessel detection (AVD) software to guide transarterial embolization (TAE) of angiographically challenging arterial bleedings in emergency settings. Twenty patients with an arterial bleeding at computed tomography angiography and an inconclusive identification of the bleeding vessel at the initial 2D angiographic series were included. Accuracy of DP-CBCT and AVD software were defined as the ability to detect the bleeding site and the culprit arterial bleeder, respectively. Technical success was defined as the correct positioning of the microcatheter using AVD software. Clinical success was defined as the successful embolization. Total volume of iodinated contrast medium and overall procedure time were registered. The bleeding site was not detected by initial angiogram in 20% of cases, while impossibility to identify the bleeding vessel was the reason for inclusion in the remaining cases. The bleeding site was detected by DP-CBCT in 19 of 20 (95%) patients; in one case CBCT-CT fusion was required. AVD software identified the culprit arterial branch in 18 of 20 (90%) cases. In two cases, vessel tracking required manual marking of the candidate arterial bleeder. Technical success was 95%. Successful embolization was achieved in all patients. Mean contrast volume injected for each patient was 77.5 ml, and mean overall procedural time was 50 min. C-arm CBCT and AVD software during TAE of angiographically challenging arterial bleedings is feasible and may facilitate successful embolization. Staff training in CBCT imaging and software manipulation is necessary.

3D tomography of midlatitude sporadic-E in Japan from GNSS-TEC data

NASA Astrophysics Data System (ADS)

Muafiry, Ihsan Naufal; Heki, Kosuke; Maeda, Jun

2018-03-01

We studied ionospheric irregularities caused by midlatitude sporadic-E ( Es) in Japan using ionospheric total electron content (TEC) data from a dense GNSS array, GEONET, with a 3D (three-dimensional) tomography technique. Es is a thin layer of unusually high ionization that appears at altitudes of 100 km. Here, we studied five cases of Es irregularities in 2010 and 2012, also reported in previous studies, over the Kanto and Kyushu Districts. We used slant TEC residuals as the input and estimated the number of electron density anomalies of more than 2000 small blocks with dimensions of 20-30 km covering a horizontal region of 300 × 500 km. We applied a continuity constraint to stabilize the solution and performed several different resolution tests with synthetic data to assess the accuracy of the results. The tomography results showed that positive electron density anomalies occurred at the E region height, and the morphology and dynamics were consistent with those reported by earlier studies.

A simple approach to the joint inversion of seismic body and surface waves applied to the southwest U.S.

NASA Astrophysics Data System (ADS)

West, Michael; Gao, Wei; Grand, Stephen

2004-08-01

Body and surface wave tomography have complementary strengths when applied to regional-scale studies of the upper mantle. We present a straight-forward technique for their joint inversion which hinges on treating surface waves as horizontally-propagating rays with deep sensitivity kernels. This formulation allows surface wave phase or group measurements to be integrated directly into existing body wave tomography inversions with modest effort. We apply the joint inversion to a synthetic case and to data from the RISTRA project in the southwest U.S. The data variance reductions demonstrate that the joint inversion produces a better fit to the combined dataset, not merely a compromise. For large arrays, this method offers an improvement over augmenting body wave tomography with a one-dimensional model. The joint inversion combines the absolute velocity of a surface wave model with the high resolution afforded by body waves-both qualities that are required to understand regional-scale mantle phenomena.

Detector arrays for low-background space infrared astronomy

NASA Technical Reports Server (NTRS)

Mccreight, C. R.; Mckelvey, M. E.; Goebel, J. H.; Anderson, G. M.; Lee, J. H.

1986-01-01

The status of development and characterization tests of integrated infrared detector array technology for astronomy applications is described. The devices under development include intrinsic, extrinsic silicon, and extrinsic germanium detectors, with hybrid silicon multiplexers. Laboratory test results and successful astronomy imagery have established the usefulness of integrated arrays in low-background astronomy applications.

Detector arrays for low-background space infrared astronomy

NASA Technical Reports Server (NTRS)

Mccreight, C. R.; Mckelvey, M. E.; Goebel, J. H.; Anderson, G. M.; Lee, J. H.

1986-01-01

The status of development and characterization tests of integrated infrared detector array technology for astronomy applications is described. The devices under development include intrinsic, extrinsic silicon, and extrinsic germanium detectors, with hybrid silicon multiplexers. Laboratary test results and successful astronomy imagery have established the usefulness of integrated arrays in low-background astronomy applications.

Experimental Charging Behavior of Orion UltraFlex Array Designs

NASA Technical Reports Server (NTRS)

Golofaro, Joel T.; Vayner, Boris V.; Hillard, Grover B.

2010-01-01

The present ground based investigations give the first definitive look describing the charging behavior of Orion UltraFlex arrays in both the Low Earth Orbital (LEO) and geosynchronous (GEO) environments. Note the LEO charging environment also applies to the International Space Station (ISS). The GEO charging environment includes the bounding case for all lunar mission environments. The UltraFlex photovoltaic array technology is targeted to become the sole power system for life support and on-orbit power for the manned Orion Crew Exploration Vehicle (CEV). The purpose of the experimental tests is to gain an understanding of the complex charging behavior to answer some of the basic performance and survivability issues to ascertain if a single UltraFlex array design will be able to cope with the projected worst case LEO and GEO charging environments. Stage 1 LEO plasma testing revealed that all four arrays successfully passed arc threshold bias tests down to -240 V. Stage 2 GEO electron gun charging tests revealed that only the front side area of indium tin oxide coated array designs successfully passed the arc frequency tests

Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography

PubMed Central

Oldenburg, Amy L.; Blackmon, Richard L.; Sierchio, Justin M.

2016-01-01

Optical coherence tomography (OCT) has gained widespread application for many biomedical applications, yet the traditional array of contrast agents used in incoherent imaging modalities do not provide contrast in OCT. Owing to the high biocompatibility of iron oxides and noble metals, magnetic and plasmonic nanoparticles, respectively, have been developed as OCT contrast agents to enable a range of biological and pre-clinical studies. Here we provide a review of these developments within the past decade, including an overview of the physical contrast mechanisms and classes of OCT system hardware addons needed for magnetic and plasmonic nanoparticle contrast. A comparison of the wide variety of nanoparticle systems is also presented, where the figures of merit depend strongly upon the choice of biological application. PMID:27429543

Ultra-wideband three-dimensional optoacoustic tomography.

PubMed

Gateau, Jérôme; Chekkoury, Andrei; Ntziachristos, Vasilis

2013-11-15

Broadband optoacoustic waves generated by biological tissues excited with nanosecond laser pulses carry information corresponding to a wide range of geometrical scales. Typically, the frequency content present in the signals generated during optoacoustic imaging is much larger compared to the frequency band captured by common ultrasonic detectors, the latter typically acting as bandpass filters. To image optical absorption within structures ranging from entire organs to microvasculature in three dimensions, we implemented optoacoustic tomography with two ultrasound linear arrays featuring a center frequency of 6 and 24 MHz, respectively. In the present work, we show that complementary information on anatomical features could be retrieved and provide a better understanding on the localization of structures in the general anatomy by analyzing multi-bandwidth datasets acquired on a freshly excised kidney.

3D modelling of the human thorax for ventilation distribution measured through electrical impedance tomography

NASA Astrophysics Data System (ADS)

Fan, W. R.; Wang, H. X.

2010-11-01

Thoracic electrical impedance tomography (EIT) aims to reconstruct a cross-sectional image of the internal spatial distribution of conductivity from electrical measurements made by injecting small alternating currents via an electrode array placed on the surface of the thorax. It is a non-invasive, radiation-free monitoring technique. In this paper, true 3D thorax models with conductivity distribution or complex conductivity distribution under different ARDS conditions are built up in comparison with the 2.5D ones, and EIT-derived numeric indices are also employed for evaluation of the lung ventilation. The purpose of this paper is to study different effects of different thorax models with either conductivity or complex conductivity on the reconstructed images and ventilation indices.

Adjoint tomography of crust and upper-mantle structure beneath Continental China

NASA Astrophysics Data System (ADS)

Chen, M.; Niu, F.; Liu, Q.; Tromp, J.

2013-12-01

Four years of regional earthquake recordings from 1,869 seismic stations are used for high-resolution and high-fidelity seismic imaging of the crust and upper-mantle structure beneath Continental China. This unprecedented high-density dataset is comprised of seismograms recorded by the China Earthquake Administration Array (CEArray), NorthEast China Extended SeiSmic Array (NECESSArray), INDEPTH-IV Array, F-net and other global and regional seismic networks, and involves 1,326,384 frequency-dependent phase measurements. Adjoint tomography is applied to this unprecedented dataset, aiming to resolve detailed 3D maps of compressional and shear wavespeeds, and radial anisotropy. Contrary to traditional ray-theory based tomography, adjoint tomography takes into account full 3D wave propagation effects and off-ray-path sensitivity. In our implementation, it utilizes a spectral-element method for precise wave propagation simulations. The tomographic method starts with a 3D initial model that combines smooth radially anisotropic mantle model S362ANI and 3D crustal model Crust2.0. Traveltime and amplitude misfits are minimized iteratively based on a conjugate gradient method, harnessing 3D finite-frequency kernels computed for each updated 3D model. After 17 iterations, our inversion reveals strong correlations of 3D wavespeed heterogeneities in the crust and upper mantle with surface tectonic units, such as the Himalaya Block, the Tibetan Plateau, the Tarim Basin, the Ordos Block, and the South China Block. Narrow slab features emerge from the smooth initial model above the transition zone beneath the Japan, Ryukyu, Philippine, Izu-Bonin, Mariana and Andaman arcs. 3D wavespeed variations appear comparable to or much sharper than in high-frequency P-and S-wave models from previous studies. Moreover our results include new information, such as 3D variations of radial anisotropy and the Vp/Vs ratio, which are expected to shed new light to the composition, thermal state, flow or fabric structure in the crust and upper mantle, as well as the related dynamical processes. We intend to use these seismic images to answer important tectonic questions, namely, 1) what controls the strength of the lithosphere; 2) how does lithosphere deform during the formation of orogens, basins and plateaus; 3) how pervasive is lithospheric delamination or partial removal beneath orogens and plateaus; 3) whether or not (and how) are slab segmentation and penetration into the lower mantle linked to upwellings associated with widespread magmatism in East Asia.

Improving resistivity survey resolution at sites with limited spatial extent using buried electrode arrays

NASA Astrophysics Data System (ADS)

Kiflu, H.; Kruse, S.; Loke, M. H.; Wilkinson, P. B.; Harro, D.

2016-12-01

Electrical resistivity tomography (ERT) surveys are widely used in geological, environmental and engineering studies. However, the effectiveness of surface ERT surveys is limited by decreasing resolution with depth and near the ends of the survey line. Increasing the array length will increase depth of investigation, but may not be possible at urban sites where access is limited. One novel method of addressing these limitations while maintaining lateral coverage is to install an array of deep electrodes. Referred to here as the Multi-Electrode Resistivity Implant Technique (MERIT), self-driving pointed electrodes are implanted at depth below each surface electrode in an array, using direct-push technology. Optimal sequences of readings have been identified with the "Compare R" method of Wilkinson. Numerical, laboratory, and field case studies are applied to examine the effectiveness of the MERIT method, particularly for use in covered karst terrain. In the field case studies, resistivity images are compared against subsurface structure defined from borings, GPR surveys, and knowledge of prior land use. In karst terrain where limestone has a clay overburden, traditional surface resistivity methods suffer from lack of current penetration through the shallow clay layer. In these settings, the MERIT method is found to improve resolution of features between the surface and buried array, as well as increasing depth of penetration and enhancing imaging capabilities at the array ends. The method functions similar to a cross-borehole array between horizontal boreholes, and suffers from limitations common to borehole arrays. Inversion artifacts are common at depths close to the buried array, and because some readings involve high geometric factors, inversions are more susceptible to noise than traditional surface arrays. Results are improved by using errors from reciprocal measurements to weight the data during the inversion.

Photonic Breast Tomography and Tumor Aggressiveness Assessment

DTIC Science & Technology

2011-07-01

incorporates, in optical domain, the vector subspace classification method, Multiple Signal Classification ( MUSIC ). MUSIC was developed by Devaney...and co-workers for finding the location of scattering targets whose size is smaller than the wavelength of acoustic waves or electromagnetic waves...general area of array processing for acoustic and radar time-reversal imaging [12]. The eigenvalue equation of TR matrix is solved, and the signal and

Progress of projection computed tomography by upgrading of the beamline 37XU of SPring-8

DOE Office of Scientific and Technical Information (OSTI.GOV)

Terada, Yasuko, E-mail: yterada@spring8.or.jp; Suzuki, Yoshio; Uesugi, Kentaro

2016-01-28

Beamline 37XU at SPring-8 has been upgraded for nano-focusing applications. The length of the beamline has been extended to 80 m. By utilizing this length, the beamline has advantages for experiments such as X-ray focusing, X-ray microscopic imaging and X-ray computed tomography. Projection computed tomography measurements were carried out at experimental hutch 3 located 80 m from the light source. CT images of a microcapsule have been successfully obtained with a wide X-ray energy range.

Transportable seismic array tomography in southeast Australia: Illuminating the transition from Proterozoic to Phanerozoic lithosphere

NASA Astrophysics Data System (ADS)

Rawlinson, N.; Salmon, M.; Kennett, B. L. N.

2014-02-01

The Phanerozoic Tasmanides of eastern Australia is comprised of a series of orogenic belts that developed along the east margin of Gondwana following the breakup of the supercontinent Rodinia and subsequent formation of the Pacific Ocean. The tectonic complexities of this region have been well studied, but most work has been confined to evidence collected from the near surface, where extensive Mesozoic and Cenozoic basin cover masks large tracts of Palaeozoic basement. We apply teleseismic tomography to distant earthquake data recorded by WOMBAT - the largest transportable seismic array experiment in the southern hemisphere - to image P-wavespeed variations in the mantle lithosphere beneath the southern portion of the Tasmanides in detail. In order to seamlessly suture together the teleseismic datasets from each of the 14 sub-arrays of WOMBAT, we use P-wavespeeds from the AuSREM model to construct a laterally heterogeneous starting model that captures the long wavelength structural variations that would otherwise be lost through the use of relative arrival time residuals. Synthetic resolution tests indicate good horizontal resolution of ~ 50 km within most of the array between depths of 50-350 km. A key feature of the 3-D P-wave model is a pronounced easterly high velocity salient in the mantle lithosphere beneath the northern limit of the New England Orocline, which may indicate the presence of underpinning Proterozoic lithosphere that was instrumental in its formation. Another pronounced high velocity anomaly underlies the Curnamona Province, a large crustal block with a strong Archean provenance, which is clearly separated from the Gawler Craton to the west at upper mantle depths by a low velocity zone beneath the Adelaide Fold Belt. We also estimate the location of the eastern boundary of Precambrian Australia at depth, and show that it extends eastward further than previously thought.

20 year IRIS: impact on seismological research at home and abroad

NASA Astrophysics Data System (ADS)

van der Hilst, R. D.

2004-12-01

: The positive impact of IRIS, through its programs (GSN, PASSCAL, DMS, EO) and its workshops, on seismological research and community building can hardly be overestimated. The Data Management System has been very successful in bringing data to users for research and education anywhere in the world; it enables routine, and in many cases real time, analysis of massive amounts of waveform data for a spectacularly diverse range of studies. (I will give examples of surface wave tomography and inverse scattering studies of the core mantle boundary.) The support that PASSCAL provides for the planning and execution of field campaigns allows seismologists to shift attention from operational issues to exciting science, and the required data dissemination through DMS does not only result in tremendously valuable data sets but also contributes to community building through (international) collaboration. Europe, Australia, and Asia also have rich histories of network and portable array seismometry, and in many areas the cumulative station density exceeds that of North America (even, perhaps, with USArray). Moreover, in some cases, such as the use of temporary, roving arrays of broad band seismometers, activities overseas may have preceded and inspired developments in the US. However, the absence of effective central systems for management and dissemination of quality-controlled data has left many unique historical and regional data sets underutilized. This situation is changing, however. As an example I will mention the NERIES initiative to build a better infrastructure for seismological research and education in Europe. Apart from providing an example, through international collaboration IRIS can continue to play an important role in the improvement of the global seismological infrastructure.

Synchrotron-based X-ray computed tomography during compression loading of cellular materials

DOE PAGES

Cordes, Nikolaus L.; Henderson, Kevin; Stannard, Tyler; ...

2015-04-29

Three-dimensional X-ray computed tomography (CT) of in situ dynamic processes provides internal snapshot images as a function of time. Tomograms are mathematically reconstructed from a series of radiographs taken in rapid succession as the specimen is rotated in small angular increments. In addition to spatial resolution, temporal resolution is important. Thus temporal resolution indicates how close together in time two distinct tomograms can be acquired. Tomograms taken in rapid succession allow detailed analyses of internal processes that cannot be obtained by other means. This article describes the state-of-the-art for such measurements acquired using synchrotron radiation as the X-ray source.

Parallel scheduling of recursively defined arrays

NASA Technical Reports Server (NTRS)

Myers, T. J.; Gokhale, M. B.

1986-01-01

A new method of automatic generation of concurrent programs which constructs arrays defined by sets of recursive equations is described. It is assumed that the time of computation of an array element is a linear combination of its indices, and integer programming is used to seek a succession of hyperplanes along which array elements can be computed concurrently. The method can be used to schedule equations involving variable length dependency vectors and mutually recursive arrays. Portions of the work reported here have been implemented in the PS automatic program generation system.

Highly Flexible Silicone Coated Neural Array for Intracochlear Electrical Stimulation

PubMed Central

Bhatti, P.; Van Beek-King, J.; Sharpe, A.; Crawford, J.; Tridandapani, S.; McKinnon, B.; Blake, D.

2015-01-01

We present an effective method for tailoring the flexibility of a commercial thin-film polymer electrode array for intracochlear electrical stimulation. Using a pneumatically driven dispensing system, an average 232 ± 64 μm (mean ± SD) thickness layer of silicone adhesive coating was applied to stiffen the underside of polyimide multisite arrays. Additional silicone was applied to the tip to protect neural tissue during insertion and along the array to improve surgical handling. Each array supported 20 platinum sites (180 μm dia., 250 μm pitch), spanning nearly 28 mm in length and 400 μm in width. We report an average intracochlear stimulating current threshold of 170 ± 93 μA to evoke an auditory brainstem response in 7 acutely deafened felines. A total of 10 arrays were each inserted through a round window approach into the cochlea's basal turn of eight felines with one delamination occurring upon insertion (preliminary results of the in vivo data presented at the 48th Annual Meeting American Neurotology Society, Orlando, FL, April 2013, and reported in Van Beek-King 2014). Using microcomputed tomography imaging (50 μm resolution), distances ranging from 100 to 565 μm from the cochlea's central modiolus were measured. Our method combines the utility of readily available commercial devices with a straightforward postprocessing step on the order of 24 hours. PMID:26236714

Interferometric tomography of continuous fields with incomplete projections

NASA Technical Reports Server (NTRS)

Cha, Soyoung S.; Sun, Hogwei

1988-01-01

Interferometric tomography in the presence of an opaque object is investigated. The developed iterative algorithm does not need to augment the missing information. It is based on the successive reconstruction of the difference field, the difference between the object field to be reconstructed and its estimate, only in the difined region. The application of the algorithm results in stable convergence.

Klystron having electrostatic quadrupole focusing arrangement

DOEpatents

Maschke, Alfred W.

1983-08-30

A klystron includes a source for emitting at least one electron beam, and an accelerator for accelarating the beam in a given direction through a number of drift tube sections successively aligned relative to one another in the direction of the beam. A number of electrostatic quadrupole arrays are successively aligned relative to one another along at least one of the drift tube sections in the beam direction for focusing the electron beam. Each of the electrostatic quadrupole arrays forms a different quadrupole for each electron beam. Two or more electron beams can be maintained in parallel relationship by the quadrupole arrays, thereby enabling space charge limitations encountered with conventional single beam klystrons to be overcome.

Klystron having electrostatic quadrupole focusing arrangement

DOEpatents

Maschke, A.W.

1983-08-30

A klystron includes a source for emitting at least one electron beam, and an accelerator for accelerating the beam in a given direction through a number of drift tube sections successively aligned relative to one another in the direction of the beam. A number of electrostatic quadrupole arrays are successively aligned relative to one another along at least one of the drift tube sections in the beam direction for focusing the electron beam. Each of the electrostatic quadrupole arrays forms a different quadrupole for each electron beam. Two or more electron beams can be maintained in parallel relationship by the quadrupole arrays, thereby enabling space charge limitations encountered with conventional single beam klystrons to be overcome. 4 figs.

Retinal Anatomy and Electrode Array Position in Retinitis Pigmentosa Patients after Argus II Implantation: an International Study.

PubMed

Gregori, Ninel Z; Callaway, Natalia F; Hoeppner, Catherine; Yuan, Alex; Rachitskaya, Aleksandra; Feuer, William; Ameri, Hossein; Arevalo, J Fernando; Augustin, Albert J; Birch, David G; Dagnelie, Gislin; Grisanti, Salvatore; Davis, Janet L; Hahn, Paul; Handa, James T; Ho, Allen C; Huang, Suber S; Humayun, Mark S; Iezzi, Raymond; Jayasundera, K Thiran; Kokame, Gregg T; Lam, Byron L; Lim, Jennifer I; Mandava, Naresh; Montezuma, Sandra R; Olmos de Koo, Lisa; Szurman, Peter; Vajzovic, Lejla; Wiedemann, Peter; Weiland, James; Yan, Jiong; Zacks, David N

2018-06-22

To assess the retinal anatomy and array position in the Argus II Retinal Prosthesis recipients. Prospective, non-comparative cohort study METHODS: Setting: international multicenter study PATIENTS: Argus II recipients enrolled in the Post-Market Surveillance Studies. Spectral-domain Optical Coherence Tomography images collected for the Surveillance Studies (NCT01860092 and NCT01490827) were reviewed. Baseline and postoperative macular thickness, electrode-retina distance (gap), optic disc-array overlap, and preretinal membrane presence were recorded at 1, 3, 6, and 12 months. Axial retinal thickness and axial gap along the array's long axis (a line between the tack and handle), maximal retinal thickness and maximal gap along a B-scan near the tack, midline, and handle. Thirty-three patients from 16 surgical sites in the United States and Germany were included. Mean axial retinal thickness increased from month 1 through month 12 at each location, but reached statistical significance only at the array midline (p-value=0.007). The rate of maximal thickness increase was highest near the array midline (slope=6.02, p=0.004), compared to the tack (slope=3.60, p<0.001) or the handle (slope=1.93, p=0.368). The mean axial and maximal gaps decreased over the study period, and the mean maximal gap size decrease was significant at midline (p=0.032). Optic disc-array overlap was seen in the minority of patients. Preretinal membranes were common before and after implantation. Progressive macular thickening under the array was common and corresponded to decreased electrode-retina gap over time. By month 12, the array was completely apposed to the macula in approximately half of the eyes. Copyright © 2018. Published by Elsevier Inc.

Solar array stepping problems in satellites and solutions

NASA Astrophysics Data System (ADS)

Maharana, P. K.; Goel, P. S.

1992-01-01

The dynamics problems arising due to stepping motion of the solar arrays of spacecraft are studied. To overcome these problems, design improvements in the drive logic based on the phase plane analysis are suggested. The improved designs are applied to the Solar Array Drive Assembly (SADA) of IRS-1B and INSAT-2A satellites. In addition, an alternate torquing strategy for very successful slewing of the arrays, and with minimum excitation of flexible modes, is proposed.

HKUST-1 Membranes Anchored on Porous Substrate by Hetero MIL-110 Nanorod Array Seeds.

PubMed

Mao, Yiyin; Cao, Wei; Li, Junwei; Sun, Luwei; Peng, Xinsheng

2013-09-02

Great anchors and seeds: Hetero-seeding growth processes and anchored nanorod arrays were successfully utilized in the synthesis of HKUST-1 membranes. These arrays were firmly anchored on porous substrates by using a MIL-110 nanorod array as both the anchor and seed. The resulting HKUST-1 membranes demonstrated good separation factors for binary gases exceeding the Knudson selectivity. Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.

Rapid recognition of volatile organic compounds with colorimetric sensor arrays for lung cancer screening.

PubMed

Zhong, Xianhua; Li, Dan; Du, Wei; Yan, Mengqiu; Wang, You; Huo, Danqun; Hou, Changjun

2018-06-01

Volatile organic compounds (VOCs) in breath can be used as biomarkers to identify early stages of lung cancer. Herein, we report a disposable colorimetric array that has been constructed from diverse chemo-responsive colorants. Distinguishable difference maps were plotted within 4 min for specifically targeted VOCs. Through the consideration of various chemical interactions with VOCs, the arrays successfully discriminate between 20 different volatile organic compounds in breath that are related to lung cancer. VOCs were identified either with the visualized difference maps or through pattern recognition with an accuracy of at least 90%. No uncertainties or errors were observed in the hierarchical cluster analysis (HCA). Finally, good reproducibility and stability of the array was achieved against changes in humidity. Generally, this work provides fundamental support for construction of simple and rapid VOC sensors. More importantly, this approach provides a hypothesis-free array method for breath testing via VOC profiling. Therefore, this small, rapid, non-invasive, inexpensive, and visualized sensor array is a powerful and promising tool for early screening of lung cancer. Graphical abstract A disposable colorimetric array has been developed with broadly chemo-responsive dyes to incorporate various chemical interactions, through which the arrays successfully discriminate 20 VOCs that are related to lung cancer via difference maps alone or chemometrics within 4 min. The hydrophobic porous matrix provides good stability against changes in humidity.

Seismic Velocity Structure of the Pacific Upper Mantle in the NoMelt Region from Finite-Frequency Traveltime Tomography

NASA Astrophysics Data System (ADS)

Hung, S. H.; Lin, P. Y.; Gaherty, J. B.; Russell, J. B.; Jin, G.; Collins, J. A.; Lizarralde, D.; Evans, R. L.; Hirth, G.

2017-12-01

Surface wave dispersion and magnetotelluric survey from the NoMelt Experiment conducted on 70 Ma central Pacific seafloor revealed an electrically resistive, high shear wave velocity lid of 80 km thick underlain by a non-highly conductive, low-velocity layer [Sarafian et al., 2015; Lin et al., 2016]. The vertical structure of the upper mantle consistent with these observational constraints suggests a plausible convection scenario, where the seismically fast, dehydrated lithosphere preserving very strong fossil spreading fabric moves at a constant plate speed over the hydrated, melt-free athenospheric mantle with the presence of either pressure-driven return flow or thermally-driven small scale circulation. To explore 3-D variations in compressional shear wave velocities related to the lithospheric and asthenospheric mantle dynamics, we employ a multichannel cross correlation method to measure relative traveltime residuals based on the vertical P and traverse S waveforms filtered at 10-33 s from telseismic earthquakes at epicentral distance between 30 and 98 degrees. The obtained P and S residuals show on average peak-to-peak variations of ±0.5 s and ±1 s, respectively, across the NoMelt OBS array. Particularly, the P residuals for most of the events display an asymmetrical pattern with respect to an axis oriented nearly N-S to NE-SW through the array. Preliminary ray-based P tomography results reveal similar asymmetric variations in the uppermost 100 km mantle. To verify the resulting structural features, we will further perform both the P and S traveltime tomography and resolution tests based on a multiscale finite-frequency approach which properly takes into account both the 3D off-path sensitivities of the measured residuals and data-adaptive resolution of the model.

High resolution P-wave velocity structure beneath Northeastern Tibet from multiscale seismic tomography

NASA Astrophysics Data System (ADS)

Guo, B.; Gao, X.; Chen, J.; Liu, Q.; Li, S.

2016-12-01

The continuing collision of the northward advancing Indian continent with the Eurasia results in the high elevations and thickened Tibetan Plateau. Numerous geologic and geophysical studies engaged in the mechanics of the Tibetan Plateau deformation and uplift. Many seismic experiments were deployed in south and central Tibet, such as INDEPTH and Hi-climb, but very few in northeastern Tibet. Between 2013 and 2015, The China Seismic Array-experiment operated 670 broadband seismic stations with an average station spacing of 35km. This seismic array located in northeastern Tibet and covered the Qilian Mountains, Qaidam Basin, and part of Songpan-Ganzi, Gobi-Alashan, Yangzi, and Ordos. A new multiscale seismic traveltime tomography technique with sparsity constrains were used to map the upper mantle P-wave velocity structure beneath northeastern Tibet. The seismic tomography algorithm employs sparsity constrains on the wavelet representation velocity model via the L1-norm regularization. This algorithm can efficiently deal with the uneven-sampled volume, and give multiscale images of the model. Our preliminary results can be summarized as follows: 1) in the upper mantle down to 200km, significate low-velocity anomalies exist beneath the northeastern Tibet, and slight high-velocity anomalies beneath the Qaidam basin; 2) under Gobi-Alashan, Yangzi, and Ordos, high-velocity anomalies appear to extend to a depth of 250km, this high-velocity may correspond to the lithosphere; 3) there exist relative high-velocity anomalies at depth of 250km-350km underneath north Tibet, which suggests lithospheric delamination; 4) the strong velocity contrast between north Tibet and Yangzi, Gabi-Alashan is visible down to 200km, which implies the north Tibet boundary.

Usefulness of Cone-Beam Computed Tomography and Automatic Vessel Detection Software in Emergency Transarterial Embolization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carrafiello, Gianpaolo, E-mail: gcarraf@gmail.com; Ierardi, Anna Maria, E-mail: amierardi@yahoo.it; Duka, Ejona, E-mail: ejonaduka@hotmail.com

BackgroundThis study was designed to evaluate the utility of dual phase cone beam computed tomography (DP-CBCT) and automatic vessel detection (AVD) software to guide transarterial embolization (TAE) of angiographically challenging arterial bleedings in emergency settings.MethodsTwenty patients with an arterial bleeding at computed tomography angiography and an inconclusive identification of the bleeding vessel at the initial 2D angiographic series were included. Accuracy of DP-CBCT and AVD software were defined as the ability to detect the bleeding site and the culprit arterial bleeder, respectively. Technical success was defined as the correct positioning of the microcatheter using AVD software. Clinical success was definedmore » as the successful embolization. Total volume of iodinated contrast medium and overall procedure time were registered.ResultsThe bleeding site was not detected by initial angiogram in 20 % of cases, while impossibility to identify the bleeding vessel was the reason for inclusion in the remaining cases. The bleeding site was detected by DP-CBCT in 19 of 20 (95 %) patients; in one case CBCT-CT fusion was required. AVD software identified the culprit arterial branch in 18 of 20 (90 %) cases. In two cases, vessel tracking required manual marking of the candidate arterial bleeder. Technical success was 95 %. Successful embolization was achieved in all patients. Mean contrast volume injected for each patient was 77.5 ml, and mean overall procedural time was 50 min.ConclusionsC-arm CBCT and AVD software during TAE of angiographically challenging arterial bleedings is feasible and may facilitate successful embolization. Staff training in CBCT imaging and software manipulation is necessary.« less

Detection of Old Mine Tunnels in Mexico City Highlands by Electric Resistivity Image Methods

NASA Astrophysics Data System (ADS)

Chavez, R. E.; Tejero, A.; Cifuentes-Nava, G.; HernaNdez-Quintero, J.

2013-12-01

Electrical Resistivity Tomography (ERT) methods have been applied to study cavities or subsurface subsidence threatening urbanized areas. Unfortunately, ERT-3D techniques carried out on heavily urbanized areas become a difficult task, since parallel ERT arrays cannot be deployed. Then, a conventional regular grid cannot be carried out. We present a subsidence problem located in a densely populated portion of Mexico City highlands. Since the damaged houses are in the middle of a highly populated low-class neighborhood, an unconventional ERT array had to be applied. At first, a ';T'-array formed by two perpendicular transects was applied, deployed within a small alley, that stretched from the house entrance. This study determined a tubular structure beneath the houses following an irregular path at depth. Finally, houses were demolished due to the extensive damaged in their foundations. This made possible to carry out a second ERT-3D study, which included a dipolar array called ';L' and ';Corner' arrays. Such a new work defined a similar tubular structure. The cavity entrance was discovered, when excavations were made, although its precise shape could not be defined. The ERT-3D interpretation contributed to locate and accurately determine the geometrical characteristics of the geological feature that caused the collapse of dwellings.

Wavelength-division multiplexed optical integrated circuit with vertical diffraction grating

NASA Technical Reports Server (NTRS)

Lang, Robert J. (Inventor); Forouhar, Siamak (Inventor)

1994-01-01

A semiconductor optical integrated circuit for wave division multiplexing has a semiconductor waveguide layer, a succession of diffraction grating points in the waveguide layer along a predetermined diffraction grating contour, a semiconductor diode array in the waveguide layer having plural optical ports facing the succession of diffraction grating points along a first direction, respective semiconductor diodes in the array corresponding to respective ones of a predetermined succession of wavelengths, an optical fiber having one end thereof terminated at the waveguide layer, the one end of the optical fiber facing the succession of diffraction grating points along a second direction, wherein the diffraction grating points are spatially distributed along the predetermined contour in such a manner that the succession of diffraction grating points diffracts light of respective ones of the succession of wavelengths between the one end of the optical fiber and corresponding ones of the optical ports.

Label-free high-throughput detection and quantification of circulating melanoma tumor cell clusters by linear-array-based photoacoustic tomography

NASA Astrophysics Data System (ADS)

Hai, Pengfei; Zhou, Yong; Zhang, Ruiying; Ma, Jun; Li, Yang; Shao, Jin-Yu; Wang, Lihong V.

2017-04-01

Circulating tumor cell (CTC) clusters, arising from multicellular groupings in a primary tumor, greatly elevate the metastatic potential of cancer compared with single CTCs. High-throughput detection and quantification of CTC clusters are important for understanding the tumor metastatic process and improving cancer therapy. Here, we applied a linear-array-based photoacoustic tomography (LA-PAT) system and improved the image reconstruction for label-free high-throughput CTC cluster detection and quantification in vivo. The feasibility was first demonstrated by imaging CTC cluster ex vivo. The relationship between the contrast-to-noise ratios (CNRs) and the number of cells in melanoma tumor cell clusters was investigated and verified. Melanoma CTC clusters with a minimum of four cells could be detected, and the number of cells could be computed from the CNR. Finally, we demonstrated imaging of injected melanoma CTC clusters in rats in vivo. Similarly, the number of cells in the melanoma CTC clusters could be quantified. The data showed that larger CTC clusters had faster clearance rates in the bloodstream, which agreed with the literature. The results demonstrated the capability of LA-PAT to detect and quantify melanoma CTC clusters in vivo and showed its potential for tumor metastasis study and cancer therapy.

Spectral domain optical coherence tomography with dual-balanced detection

NASA Astrophysics Data System (ADS)

Bo, En; Liu, Xinyu; Chen, Si; Luo, Yuemei; Wang, Nanshuo; Wang, Xianghong; Liu, Linbo

2016-03-01

We developed a spectral domain optical coherence tomography (SD-OCT) system employing dual-balanced detection (DBD) for direct current term suppression and SNR enhancement, especially for auto-autocorrelation artifacts reduction. The DBD was achieved by using a beam splitter to building a free-space Michelson interferometer, which generated two interferometric spectra with a phase difference of π. These two phase-opposed spectra were guided to the spectrometer through two single mode fibers of the 8 fiber v-groove array and acquired by ultizing the upper two lines of a three-line CCD camera. We rotated this fiber v-groove array by 1.35 degrees to focus two spectra onto the first and second line of the CCD camera. Two spectra were aligned by optimum spectrum matching algorithm. By subtracting one spectrum from the other, this dual-balanced detection system achieved a direct current term suppression of ~30 dB, SNR enhancement of ~3 dB, and auto-autocorrelation artifacts reduction of ~10 dB experimentally. Finally we respectively validated the feasibility and performance of dual-balanced detection by imaging a glass plate and swine corneal tissue ex vivo. The quality of images obtained using dual-balanced detection was significantly improved with regard to the conventional single-detection (SD) images.

Multispectral photoacoustic tomography for detection of small tumors inside biological tissues

NASA Astrophysics Data System (ADS)

Hirasawa, Takeshi; Okawa, Shinpei; Tsujita, Kazuhiro; Kushibiki, Toshihiro; Fujita, Masanori; Urano, Yasuteru; Ishihara, Miya

2018-02-01

Visualization of small tumors inside biological tissue is important in cancer treatment because that promotes accurate surgical resection and enables therapeutic effect monitoring. For sensitive detection of tumor, we have been developing photoacoustic (PA) imaging technique to visualize tumor-specific contrast agents, and have already succeeded to image a subcutaneous tumor of a mouse using the contrast agents. To image tumors inside biological tissues, extension of imaging depth and improvement of sensitivity were required. In this study, to extend imaging depth, we developed a PA tomography (PAT) system that can image entire cross section of mice. To improve sensitivity, we discussed the use of the P(VDF-TrFE) linear array acoustic sensor that can detect PA signals with wide ranges of frequencies. Because PA signals produced from low absorbance optical absorbers shifts to low frequency, we hypothesized that the detection of low frequency PA signals improves sensitivity to low absorbance optical absorbers. We developed a PAT system with both a PZT linear array acoustic sensor and the P(VDF-TrFE) sensor, and performed experiment using tissue-mimicking phantoms to evaluate lower detection limits of absorbance. As a result, PAT images calculated from low frequency components of PA signals detected by the P(VDF-TrFE) sensor could visualize optical absorbers with lower absorbance.

The Stretched Lens Array (SLA): A Low-Risk, Cost-Effective Array Offering Wing-Level Performance of 180 W/KG and 300 W/M2 at 300 VDC

NASA Technical Reports Server (NTRS)

ONeill, Mark; Piszczor, Michael F.; Eskenazi, Michael I.; McDanal, A. J.; George, Patrick J.; Botke, Matthew M.; Brandhorst, Henry W.; Edwards, David L.; Jaster, Paul A.; Lyons, Valerie J. (Technical Monitor)

2002-01-01

At IECEC 2001, our team presented a paper on the new stretched lens array (SLA), including its evolution from the successful SCARLET array on the NASA/JPL Deep Space 1 spacecraft. Since that conference, the SLA team has made significant advances in the SLA technology, including component-level improvements, array-level optimization, space environment exposure testing, and prototype hardware fabrication and evaluation. This paper describes the evolved version of the SLA, highlighting recent improvements in the lens, solar cell, photovoltaic receiver, rigid panel structure, and complete solar array wing.

MnO 2 nanotube and nanowire arrays by electrochemical deposition for supercapacitors

NASA Astrophysics Data System (ADS)

Xia, Hui; Feng, Jinkui; Wang, Hailong; Lai, Man On; Lu, Li

Highly ordered MnO 2 nanotube and nanowire arrays are successfully synthesized via a electrochemical deposition technique using porous alumina templates. The morphologies and microstructures of the MnO 2 nanotube and nanowire arrays are investigated by field emission scanning electron microscopy and transmission electron microscopy. Electrochemical characterization demonstrates that the MnO 2 nanotube array electrode has superior capacitive behaviour to that of the MnO 2 nanowire array electrode. In addition to high specific capacitance, the MnO 2 nanotube array electrode also exhibits good rate capability and good cycling stability, which makes it promising candidate for supercapacitors.

Performance Analysis of a Cost-Effective Electret Condenser Microphone Directional Array

NASA Technical Reports Server (NTRS)

Humphreys, William M., Jr.; Gerhold, Carl H.; Zuckerwar, Allan J.; Herring, Gregory C.; Bartram, Scott M.

2003-01-01

Microphone directional array technology continues to be a critical part of the overall instrumentation suite for experimental aeroacoustics. Unfortunately, high sensor cost remains one of the limiting factors in the construction of very high-density arrays (i.e., arrays containing several hundred channels or more) which could be used to implement advanced beamforming algorithms. In an effort to reduce the implementation cost of such arrays, the authors have undertaken a systematic performance analysis of a prototype 35-microphone array populated with commercial electret condenser microphones. An ensemble of microphones coupling commercially available electret cartridges with passive signal conditioning circuitry was fabricated for use with the Langley Large Aperture Directional Array (LADA). A performance analysis consisting of three phases was then performed: (1) characterize the acoustic response of the microphones via laboratory testing and calibration, (2) evaluate the beamforming capability of the electret-based LADA using a series of independently controlled point sources in an anechoic environment, and (3) demonstrate the utility of an electret-based directional array in a real-world application, in this case a cold flow jet operating at high subsonic velocities. The results of the investigation revealed a microphone frequency response suitable for directional array use over a range of 250 Hz - 40 kHz, a successful beamforming evaluation using the electret-populated LADA to measure simple point sources at frequencies up to 20 kHz, and a successful demonstration using the array to measure noise generated by the cold flow jet. This paper presents an overview of the tests conducted along with sample data obtained from those tests.

High-repetition-rate optical delay line using a micromirror array and galvanometer mirror for a terahertz system.

PubMed

Kitahara, Hideaki; Tani, Masahiko; Hangyo, Masanori

2009-07-01

We developed a high-repetition-rate optical delay line based on a micromirror array and galvanometer mirror for terahertz time-domain spectroscopy. The micromirror array is fabricated by using the x-ray lithographic technology. The measurement of terahertz time-domain waveforms with the new optical delay line is demonstrated successfully up to 25 Hz.

Coated microneedle arrays for transcutaneous delivery of live virus vaccines

PubMed Central

Vrdoljak, Anto; McGrath, Marie G.; Carey, John B.; Draper, Simon J.; Hill, Adrian V.S.; O’Mahony, Conor; Crean, Abina M.; Moore, Anne C.

2016-01-01

Vaccines are sensitive biologics that require continuous refrigerated storage to maintain their viability. The vast majority of vaccines are also administered using needles and syringes. The need for cold chain storage and the significant logistics surrounding needle-and-syringe vaccination is constraining the success of immunization programs. Recombinant live viral vectors are a promising platform for the development of vaccines against a number of infectious diseases, however these viruses must retain infectivity to be effective. Microneedles offer an effective and painless method for delivery of vaccines directly into skin that in the future could provide solutions to current vaccination issues. Here we investigated methods of coating live recombinant adenovirus and modified vaccinia virus Ankara (MVA) vectors onto solid microneedle arrays. An effective spray-coating method, using conventional pharmaceutical processes, was developed, in tandem with suitable sugar-based formulations, which produces arrays with a unique coating of viable virus in a dry form around the shaft of each microneedle on the array. Administration of live virus-coated microneedle arrays successfully resulted in virus delivery, transcutaneous infection and induced an antibody or CD8+ T cell response in mice that was comparable to that obtained by needle-and-syringe intradermal immunization. To our knowledge, this is the first report of successful vaccination with recombinant live viral vectored vaccines coated on microneedle delivery devices. PMID:22245683

Coated microneedle arrays for transcutaneous delivery of live virus vaccines.

PubMed

Vrdoljak, Anto; McGrath, Marie G; Carey, John B; Draper, Simon J; Hill, Adrian V S; O'Mahony, Conor; Crean, Abina M; Moore, Anne C

2012-04-10

Vaccines are sensitive biologics that require continuous refrigerated storage to maintain their viability. The vast majority of vaccines are also administered using needles and syringes. The need for cold chain storage and the significant logistics surrounding needle-and-syringe vaccination is constraining the success of immunization programs. Recombinant live viral vectors are a promising platform for the development of vaccines against a number of infectious diseases, however these viruses must retain infectivity to be effective. Microneedles offer an effective and painless method for delivery of vaccines directly into skin that in the future could provide solutions to current vaccination issues. Here we investigated methods of coating live recombinant adenovirus and modified vaccinia virus Ankara (MVA) vectors onto solid microneedle arrays. An effective spray-coating method, using conventional pharmaceutical processes, was developed, in tandem with suitable sugar-based formulations, which produces arrays with a unique coating of viable virus in a dry form around the shaft of each microneedle on the array. Administration of live virus-coated microneedle arrays successfully resulted in virus delivery, transcutaneous infection and induced an antibody or CD8(+) T cell response in mice that was comparable to that obtained by needle-and-syringe intradermal immunization. To our knowledge, this is the first report of successful vaccination with recombinant live viral vectored vaccines coated on microneedle delivery devices. Copyright © 2011 Elsevier B.V. All rights reserved.

High-Throughput Generation of Durable Droplet Arrays for Single-Cell Encapsulation, Culture, and Monitoring.

PubMed

Wu, Han; Chen, Xinlian; Gao, Xinghua; Zhang, Mengying; Wu, Jinbo; Wen, Weijia

2018-04-03

High-throughput measurements can be achieved using droplet-based assays. In this study, we exploited the principles of wetting behavior and capillarity to guide liquids sliding along a solid surface with hybrid wettability. Oil-covered droplet arrays with uniformly sized and regularly shaped picoliter droplets were successfully generated on hydrophilic-in-hydrophobic patterned substrates. More than ten thousand 31-pL droplets were generated in 5 s without any sophisticated instruments. Covering the droplet arrays with oil during generation not only isolated the droplets from each other but also effectively prevented droplet evaporation. The oil-covered droplet arrays could be stored for more than 2 days with less than 35% volume loss. Single microspheres, microbial cells, or mammalian cells were successfully captured in the droplets. We demonstrate that Escherichia coli could be encapsulated at a certain number (1-4) and cultured for 3 days in droplets. Cell population and morphology were dynamically tracked within individual droplets. Our droplet array generation method enables high-throughput processing and is facile, efficient, and low-cost; in addition, the prepared droplet arrays have enormous potential for applications in chemical and biological assays.

Compressed sensing for ultrasound computed tomography.

PubMed

van Sloun, Ruud; Pandharipande, Ashish; Mischi, Massimo; Demi, Libertario

2015-06-01

Ultrasound computed tomography (UCT) allows the reconstruction of quantitative tissue characteristics, such as speed of sound, mass density, and attenuation. Lowering its acquisition time would be beneficial; however, this is fundamentally limited by the physical time of flight and the number of transmission events. In this letter, we propose a compressed sensing solution for UCT. The adopted measurement scheme is based on compressed acquisitions, with concurrent randomised transmissions in a circular array configuration. Reconstruction of the image is then obtained by combining the born iterative method and total variation minimization, thereby exploiting variation sparsity in the image domain. Evaluation using simulated UCT scattering measurements shows that the proposed transmission scheme performs better than uniform undersampling, and is able to reduce acquisition time by almost one order of magnitude, while maintaining high spatial resolution.

A Clinical Evaluation of Cone Beam Computed Tomography

DTIC Science & Technology

2015-06-01

the extent of dental caries . The radiographic image is essential to successfully diagnose pathosis of odontogenic and non-odontogenic origin. The...A CLINICAL EVALUATION OF CONE BEAM COMPUTED TOMOGRAPHY by Thomas Patrick Cairnll, D.D.S. Commander, Dental Corps United States Navy A thesis...submitted to the Faculty of the Endodontics Graduate Program Naval Postgraduate Dental School Uniformed Services University of the Health Sciences in

Laser Scattering Tomography for the Study of Defects in Protein Crystals

NASA Technical Reports Server (NTRS)

Feigelson, Robert S.; DeLucas, Lawrence; DeMattei, R. C.

1997-01-01

The goal of this research is to explore the application of the non-destructive technique of Laser Scattering Tomography (LST) to study the defects in protein crystals and relate them to the x-ray diffraction performance of the crystals. LST has been used successfully for the study of defects in inorganic crystals and. in the case of lysozyme, for protein crystals.

A phoswich detector design for improved spatial sampling in PET

NASA Astrophysics Data System (ADS)

Thiessen, Jonathan D.; Koschan, Merry A.; Melcher, Charles L.; Meng, Fang; Schellenberg, Graham; Goertzen, Andrew L.

2018-02-01

Block detector designs, utilizing a pixelated scintillator array coupled to a photosensor array in a light-sharing design, are commonly used for positron emission tomography (PET) imaging applications. In practice, the spatial sampling of these designs is limited by the crystal pitch, which must be large enough for individual crystals to be resolved in the detector flood image. Replacing the conventional 2D scintillator array with an array of phoswich elements, each consisting of an optically coupled side-by-side scintillator pair, may improve spatial sampling in one direction of the array without requiring resolving smaller crystal elements. To test the feasibility of this design, a 4 × 4 phoswich array was constructed, with each phoswich element consisting of two optically coupled, 3 . 17 × 1 . 58 × 10mm3 LSO crystals co-doped with cerium and calcium. The amount of calcium doping was varied to create a 'fast' LSO crystal with decay time of 32.9 ns and a 'slow' LSO crystal with decay time of 41.2 ns. Using a Hamamatsu R8900U-00-C12 position-sensitive photomultiplier tube (PS-PMT) and a CAEN V1720 250 MS/s waveform digitizer, we were able to show effective discrimination of the fast and slow LSO crystals in the phoswich array. Although a side-by-side phoswich array is feasible, reflections at the crystal boundary due to a mismatch between the refractive index of the optical adhesive (n = 1 . 5) and LSO (n = 1 . 82) caused it to behave optically as an 8 × 4 array rather than a 4 × 4 array. Direct coupling of each phoswich element to individual photodetector elements may be necessary with the current phoswich array design. Alternatively, in order to implement this phoswich design with a conventional light sharing PET block detector, a high refractive index optical adhesive is necessary to closely match the refractive index of LSO.

An ANSERLIN array for mobile satellite applications

NASA Technical Reports Server (NTRS)

Colomb, F. Y.; Kunkee, D. B.; Mayes, P. E.; Smith, D. W.; Jamnejad, V.

1990-01-01

Design, analysis, construction, and test of linear arrays of ANSERLIN (annular sector, radiating line) elements are reported and discussed. Due to feeding simplicity and easy construction as well as good CP performance, a planar array composed of a number of such linear arrays each producing a shaped beam tilted in elevation, is a good candidate as a vehicle-mounted mechanically steered antenna for mobile satellite applications. A single level construction technique was developed that makes this type of array very cost competitive with other low-profile arrays. An asymmetric 19.5 inch long four-element array was fabricated and tested with reasonable performance. A smaller five-element symmetric array (16 inch long) was also designed and tested capable of operating in either sense of circular polarization. Efforts were made to successfully reduce this effect.

Development of a multiplexed readout with high position resolution for positron emission tomography

NASA Astrophysics Data System (ADS)

Lee, Sangwon; Choi, Yong; Kang, Jihoon; Jung, Jin Ho

2017-04-01

Detector signals for positron emission tomography (PET) are commonly multiplexed to reduce the number of digital processing channels so that the system can remain cost effective while also maintaining imaging performance. In this work, a multiplexed readout combining Anger position estimation algorithm and position decoder circuit (PDC) was developed to reduce the number of readout channels by a factor of 24, 96-to-4. The data acquisition module consisted of a TDC (50 ps resolution), 4-channel ADCs (12 bit, 105 MHz sampling rate), 2 GB SDRAM and USB3.0. The performance of the multiplexed readout was assessed with a high-resolution PET detector block composed of 2×3 detector modules, each consisting of an 8×8 array of 1.52×1.52×6 mm3 LYSO, a 4×4 array of 3×3 mm2 silicon photomultiplier (SiPM) and 13.4×13.4 mm2 light guide with 0.7 mm thickness. The acquired flood histogram showed that all 384 crystals could be resolved. The average energy resolution at 511 keV was 13.7±1.6% full-width-at-half-maximum (FWHM) and the peak-to-valley ratios of the flood histogram on the horizontal and vertical lines were 18.8±0.8 and 22.8±1.3, respectively. The coincidence resolving time of a pair of detector blocks was 6.2 ns FWHM. The reconstructed phantom image showed that rods down to a diameter of 1.6 mm could be resolved. The results of this study indicate that the multiplexed readout would be useful in developing a PET with a spatial resolution less than the pixel size of the photosensor, such as a SiPM array.

Rayleigh Wave Tomography of Mid-Continent Rift (MCR) using Earthquake and Ambient Noise Data

NASA Astrophysics Data System (ADS)

Aleqabi, G. I.; Wiens, D.; Wysession, M. E.; Shen, W.; van der Lee, S.; Revenaugh, J.; Frederiksen, A. W.; Darbyshire, F. A.; Stein, S. A.; Jurdy, D. M.; Wolin, E.; Bollmann, T. A.

2015-12-01

The structure of the North American Mid-Continent Rift Zone (MCRZ) is examined using Rayleigh waves from teleseismic earthquakes and ambient seismic noise recorded by the Superior Province Rifting EarthScope Experiment (SPREE). Eighty-four broadband seismometers were deployed during 2011-2013 in Minnesota and Wisconsin, USA, and Ontario, CA, along three lines; two across the rift axis and the third along the rift axis. These stations, together with the EarthScope Transportable Array, provided excellent coverage of the MCRZ. The 1.1 Ga Mesoproterozoic failed rift consists of two arms, buried under post-rifting sedimentary formations that meet at Lake Superior. We compare two array-based tomography methods using teleseismic fundamental mode Rayleigh waves phase and amplitude measurements: the two-plane wave method (TPWM, Forsyth, 1998) and the automated surface wave phase velocity measuring system (ASWMS, Jin and Gaherty, 2015). Both array methods and the ambient noise method give relatively similar results showing low velocity zones extending along the MCRZ arms. The teleseismic Rayleigh wave results from 18 - 180 s period are combined with short period phase velocity results (period 8-30 s) obtained from ambient noise by cross correlation. Phase velocities from the methods are very similar at periods of 18-30 where results overlap; in this period range we use the average of the noise and teleseismic results. Finally the combined phase velocity curve is inverted using a Monte-Carlo inversion method at each geographic point in the model. The results show low velocities at shallow depths (5-10 km) that are the result of very deep sedimentary fill within the MCRZ. Deeper-seated low velocity regions may correspond to mafic underplating of the rift zone.

Highly efficient and completely flexible fiber-shaped dye-sensitized solar cell based on TiO2 nanotube array

NASA Astrophysics Data System (ADS)

Lv, Zhibin; Yu, Jiefeng; Wu, Hongwei; Shang, Jian; Wang, Dan; Hou, Shaocong; Fu, Yongping; Wu, Kai; Zou, Dechun

2012-02-01

A type of highly efficient completely flexible fiber-shaped solar cell based on TiO2 nanotube array is successfully prepared. Under air mass 1.5G (100 mW cm-2) illumination conditions, the photoelectric conversion efficiency of the solar cell approaches 7%, the highest among all fiber-shaped cells based on TiO2 nanotube arrays and the first completely flexible fiber-shaped DSSC. The fiber-shaped solar cell demonstrates good flexibility, which makes it suitable for modularization using weaving technologies.A type of highly efficient completely flexible fiber-shaped solar cell based on TiO2 nanotube array is successfully prepared. Under air mass 1.5G (100 mW cm-2) illumination conditions, the photoelectric conversion efficiency of the solar cell approaches 7%, the highest among all fiber-shaped cells based on TiO2 nanotube arrays and the first completely flexible fiber-shaped DSSC. The fiber-shaped solar cell demonstrates good flexibility, which makes it suitable for modularization using weaving technologies. Electronic supplementary information (ESI) available. See DOI: 10.1039/c2nr11532h

Cone-beam computed tomography fusion and navigation for real-time positron emission tomography-guided biopsies and ablations: a feasibility study.

PubMed

Abi-Jaoudeh, Nadine; Mielekamp, Peter; Noordhoek, Niels; Venkatesan, Aradhana M; Millo, Corina; Radaelli, Alessandro; Carelsen, Bart; Wood, Bradford J

2012-06-01

To describe a novel technique for multimodality positron emission tomography (PET) fusion-guided interventions that combines cone-beam computed tomography (CT) with PET/CT before the procedure. Subjects were selected among patients scheduled for a biopsy or ablation procedure. The lesions were not visible with conventional imaging methods or did not have uniform uptake on PET. Clinical success was defined by adequate histopathologic specimens for molecular profiling or diagnosis and by lack of enhancement on follow-up imaging for ablation procedures. Time to target (time elapsed between the completion of the initial cone-beam CT scan and first tissue sample or treatment), total procedure time (time from the moment the patient was on the table until the patient was off the table), and number of times the needle was repositioned were recorded. Seven patients underwent eight procedures (two ablations and six biopsies). Registration and procedures were completed successfully in all cases. Clinical success was achieved in all biopsy procedures and in one of the two ablation procedures. The needle was repositioned once in one biopsy procedure only. On average, the time to target was 38 minutes (range 13-54 min). Total procedure time was 95 minutes (range 51-240 min, which includes composite ablation). On average, fluoroscopy time was 2.5 minutes (range 1.3-6.2 min). An integrated cone-beam CT software platform can enable PET-guided biopsies and ablation procedures without the need for additional specialized hardware. Copyright © 2012 SIR. Published by Elsevier Inc. All rights reserved.

Integrated detector array technology for infrared astronomy

NASA Technical Reports Server (NTRS)

Mccreight, c. R.; Goebel, J. H.; Mckelvey, M. E.; Stafford, P. S.; Lee, J. H.

1984-01-01

The status of laboratory and telescope tests of integrated infrared detector array technology for astronomical applications is described. The devices tested represent a number of extrinsic and intrinsic detector materials and various multiplexer designs. Infrared arrays have now been used in successful astronomical applications. These have shown that device sensitivities can be comparable to those of discrete detector systems and excellent astronomical imagery can be produced.

Feasibility of microelectrode array (MEA) based on silicone-polyimide hybrid for retina prosthesis.

PubMed

Kim, Eui Tae; Kim, Cinoo; Lee, Seung Woo; Seo, Jong-Mo; Chung, Hum; Kim, Sung June

2009-09-01

To adopt micropatterning technology in manufacturing silicone elastomer-based microelectrode arrays for retinal stimulation, a silicone-polyimide hybrid microelectrode array was proposed and tested in vivo. Gold microelectrodes were created by semiconductor manufacturing technology based on polyimide and were hybridized with silicone elastomer by spin coating. The stability of the hybrid between the two materials was flex and blister tested. The feasibility of the hybrid electrode was evaluated in the rabbit eye by reviewing optical coherence tomography (OCT) findings after suprachoroidal implantation. The flex test showed no dehiscence between the two materials for 24 hours of alternative flexion and extension from -45.0 degrees to +45.0 degrees . During the blister test, delamination was observed at 8.33 +/- 1.36 psi of pressure stress; however, this property was improved to 11.50 +/- 1.04 psi by oxygen plasma treatment before hybridization. OCT examination revealed that the implanted electrodes were safely located in the suprachoroidal space during the 4-week follow-up period. The silicone-polyimide hybrid microelectrode array showed moderate physical properties, which are suitable for in vivo application. Appropriate pretreatment before hybridization improved electrode stability. In vivo testing indicated that this electrode is suitable as a stimulation electrode in artificial retina.

Patterned thin metal film for the lateral resolution measurement of photoacoustic tomography

PubMed Central

2012-01-01

Background Image quality assessment method of photoacoustic tomography has not been completely standardized yet. Due to the combined nature of photonic signal generation and ultrasonic signal transmission in biological tissue, neither optical nor ultrasonic traditional methods can be used without modification. An optical resolution measurement technique was investigated for its feasibility for resolution measurement of photoacoustic tomography. Methods A patterned thin metal film deposited on silica glass provides high contrast in optical imaging due to high reflectivity from the metal film and high transmission from the glass. It provides high contrast when it is used for photoacoustic tomography because thin metal film can absorb pulsed laser energy. An US Air Force 1951 resolution target was used to generate patterned photoacoustic signal to measure the lateral resolution. Transducer with 2.25 MHz bandwidth and a sample submerged in water and gelatinous block were tested for lateral resolution measurement. Results Photoacoustic signal generated from a thin metal film deposited on a glass can propagate along the surface or through the surrounding medium. First, a series of experiments with tilted sample confirmed that the measured photoacoustic signal is what is propagating through the medium. Lateral resolution of the photoacoustic tomography system was successfully measured for water and gelatinous block as media: 0.33 mm and 0.35 mm in water and gelatinous material, respectively, when 2.25 MHz transducer was used. Chicken embryo was tested for biomedical applications. Conclusions A patterned thin metal film sample was tested for its feasibility of measuring lateral resolution of a photoacoustic tomography system. Lateral resolutions in water and gelatinous material were successfully measured using the proposed method. Measured resolutions agreed well with theoretical values. PMID:22794510

Reconstruction 3-dimensional image from 2-dimensional image of status optical coherence tomography (OCT) for analysis of changes in retinal thickness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arinilhaq,; Widita, Rena

2014-09-30

Optical Coherence Tomography is often used in medical image acquisition to diagnose that change due easy to use and low price. Unfortunately, this type of examination produces a two-dimensional retinal image of the point of acquisition. Therefore, this study developed a method that combines and reconstruct 2-dimensional retinal images into three-dimensional images to display volumetric macular accurately. The system is built with three main stages: data acquisition, data extraction and 3-dimensional reconstruction. At data acquisition step, Optical Coherence Tomography produced six *.jpg images of each patient were further extracted with MATLAB 2010a software into six one-dimensional arrays. The six arraysmore » are combined into a 3-dimensional matrix using a kriging interpolation method with SURFER9 resulting 3-dimensional graphics of macula. Finally, system provides three-dimensional color graphs based on the data distribution normal macula. The reconstruction system which has been designed produces three-dimensional images with size of 481 × 481 × h (retinal thickness) pixels.« less

Tomographic reconstruction of atmospheric turbulence with the use of time-dependent stochastic inversion.

PubMed

Vecherin, Sergey N; Ostashev, Vladimir E; Ziemann, A; Wilson, D Keith; Arnold, K; Barth, M

2007-09-01

Acoustic travel-time tomography allows one to reconstruct temperature and wind velocity fields in the atmosphere. In a recently published paper [S. Vecherin et al., J. Acoust. Soc. Am. 119, 2579 (2006)], a time-dependent stochastic inversion (TDSI) was developed for the reconstruction of these fields from travel times of sound propagation between sources and receivers in a tomography array. TDSI accounts for the correlation of temperature and wind velocity fluctuations both in space and time and therefore yields more accurate reconstruction of these fields in comparison with algebraic techniques and regular stochastic inversion. To use TDSI, one needs to estimate spatial-temporal covariance functions of temperature and wind velocity fluctuations. In this paper, these spatial-temporal covariance functions are derived for locally frozen turbulence which is a more general concept than a widely used hypothesis of frozen turbulence. The developed theory is applied to reconstruction of temperature and wind velocity fields in the acoustic tomography experiment carried out by University of Leipzig, Germany. The reconstructed temperature and velocity fields are presented and errors in reconstruction of these fields are studied.

Lamb mode selection for accurate wall loss estimation via guided wave tomography

NASA Astrophysics Data System (ADS)

Huthwaite, P.; Ribichini, R.; Lowe, M. J. S.; Cawley, P.

2014-02-01

Guided wave tomography offers a method to accurately quantify wall thickness losses in pipes and vessels caused by corrosion. This is achieved using ultrasonic waves transmitted over distances of approximately 1-2m, which are measured by an array of transducers and then used to reconstruct a map of wall thickness throughout the inspected region. To achieve accurate estimations of remnant wall thickness, it is vital that a suitable Lamb mode is chosen. This paper presents a detailed evaluation of the fundamental modes, S0 and A0, which are of primary interest in guided wave tomography thickness estimates since the higher order modes do not exist at all thicknesses, to compare their performance using both numerical and experimental data while considering a range of challenging phenomena. The sensitivity of A0 to thickness variations was shown to be superior to S0, however, the attenuation from A0 when a liquid loading was present was much higher than S0. A0 was less sensitive to the presence of coatings on the surface of than S0.

Photonic Breast Tomography and Tumor Aggressiveness Assessment

DTIC Science & Technology

2009-07-01

similar to the time-reversal matrix used in the general area of array processing for acoustic and radar time-reversal imaging [9]. Both OIPCA and TROT...iterative time-reversal process: analysis of the convergence,” J. Acoust . Soc. Am. 97, 62 (1995). 10. N. Kroman, J. Wohlfahrt, H. T. Mouridsen, and M...Gayen1 1The Institute for Ultrafast Spectroscopy and Lasers, Physics Department The City College and the Graduate Centre of The City University of

One to Large N Gradiometry

NASA Astrophysics Data System (ADS)

Langston, C. A.

2017-12-01

The seismic wave gradient tensor can be derived from a variety of field observations including measurements of the wavefield by a dense seismic array, strain meters, and rotation meters. Coupled with models of wave propagation, wave gradients along with the original wavefield can give estimates of wave attributes that can be used to infer wave propagation directions, apparent velocities, spatial amplitude behavior, and wave type. Compact geodetic arrays with apertures of 0.1 wavelength or less can be deployed to provide wavefield information at a localized spot similar to larger phased arrays with apertures of many wavelengths. Large N, spatially distributed arrays can provide detailed information over an area to detect structure changes. Key to accurate computation of spatial gradients from arrays of seismic instruments is knowledge of relative instrument responses, particularly component sensitivities and gains, along with relative sensor orientations. Array calibration has been successfully performed for the 14-element Pinyon Flat, California, broadband array using long-period teleseisms to achieve relative precisions as small as 0.2% in amplitude and 0.35o in orientation. Calibration has allowed successful comparison of horizontal seismic strains from local and regional seismic events with the Plate Boundary Observatory (PBO) borehole strainmeter located at the facility. Strains from the borehole strainmeter in conjunction with ground velocity from a co-located seismometer are used as a "point" array in estimating wave attributes for the P-SV components of the wavefield. An effort is underway to verify the calibration of PBO strainmeters in southern California and their co-located borehole seismic sensors to create an array of point arrays for use in studies of regional wave propagation and seismic sources.

Abstract number and arithmetic in preschool children.

PubMed

Barth, Hilary; La Mont, Kristen; Lipton, Jennifer; Spelke, Elizabeth S

2005-09-27

Educated humans use language to express abstract number, applying the same number words to seven apples, whistles, or sins. Is language or education the source of numerical abstraction? Claims to the contrary must present evidence for numerical knowledge that applies to disparate entities, in people who have received no formal mathematics instruction and cannot express such knowledge in words. Here we show that preschool children can compare and add large sets of elements without counting, both within a single visual-spatial modality (arrays of dots) and across two modalities and formats (dot arrays and tone sequences). In two experiments, children viewed animations and either compared one visible array of dots to a second array or added two successive dot arrays and compared the sum to a third array. In further experiments, a dot array was replaced by a sequence of sounds, so that participants had to integrate quantity information presented aurally and visually. Children performed all tasks successfully, without resorting to guessing strategies or responding to continuous variables. Their accuracy varied with the ratio of the two quantities: a signature of large, approximate number representations in adult humans and animals. Addition was as accurate as comparison, even though children showed no relevant knowledge when presented with symbolic versions of the addition tasks. Abstract knowledge of number and addition therefore precedes, and may guide, language-based instruction in mathematics.

Unveiling the lithospheric structure of the US Interior using the USArray Transportable Array

NASA Astrophysics Data System (ADS)

Moschetti, M. P.; Ritzwoller, M. H.; Lin, F.; Shen, W.; Yang, Y.

2009-12-01

We present current results from ambient noise tomography (ANT) and earthquake surface wave tomography applied to the USARRAY Transportable Array (TA) for the western and central US. We have processed ambient seismic noise data since October 2004 to produce cumulative Rayleigh and Love wave dispersion maps (from about 6 to 40 sec period) within the footprint of the TA. The high spatial density of these instruments results in dispersion maps with a resolution of about the average inter-station distance (70 km) and far exceeds previous surface wave tomographic results for the US interior. The dispersion maps from ANT are complemented by Rayleigh wave phase speed maps from teleseismic earthquake tomography (25 - 100 sec period). The development of a new method of surface wave tomography, termed Eikonal tomography, that models wavefront complexity and off great-circle propagation allows for the robust estimation of phase velocity azimuthal anisotropy. Eikonal tomography has been applied to ambient seismic noise and earthquake measurements and provides a means to compare and vet results in the period band of overlap (25 - 40 sec). In addition, the recent application of this method to Love waves from teleseismic earthquakes provides dispersion measurements up to 50 sec period. These longer period Love wave dispersion measurements may improve the characterization of anisotropy in the uppermost mantle. In addition to the current dispersion maps, we present regional-scale 3-D models of isotropic and anisotropic shear-velocities for the crust and uppermost mantle beneath the western US. Because dispersion measurements from ambient seismic noise include short period (<20 sec) information, they provide a strong constraint on the shear-velocity structure of the crust and uppermost mantle. A radially anisotropic shear-velocity model of the crust and uppermost mantle is constructed by simultaneously inverting Rayleigh and Love wave dispersion measurements from ANT and from earthquake tomography. Models with isotropic and radially anisotropic mantle shear-velocities do not fit the Rayleigh and Love wave measurements simultaneously across large regions of the western US, and the models present a Rayleigh-Love misfit discrepancy at the periods most sensitive to crustal velocity structures. However, by introducing positive radial anisotropy (Vsh>Vsv) to the middle and lower crust, this misfit discrepancy is resolved. Higher amplitude crustal radial anisotropy is observed in the predominant extensional provinces of the western US and is thought to result from the alignment of anisotropic crustal minerals during extension and deformation. Several regions of the western US remain poorly fit by the 3-D radially anisotropic shear-velocity model. These include the Olympic Peninsula, Mendocino Triple Junction, southern Cascadia backarc, Yakima Fold Belt, Wasatch Front, Salton Trough and Great Valley. We investigate various additional model parametrizations and the effect of breaking the constraint on the monotonic increase of crustal velocities with depth to resolve crustal shear-velocity structure in these regions. These techniques will readily be applied to data from the US Interior as the TA moves to the east.

Seismic tomography as a tool for measuring stress in mines

USGS Publications Warehouse

Scott, Douglas F.; Williams, T.J.; Denton, D.K.; Friedel, M.J.

1999-01-01

Spokane Research Center personnel have been investigating the use of seismic tomography to monitor the behavior of a rock mass, detect hazardous ground conditions and assess the mechanical integrity of a rock mass affected by mining. Seismic tomography can be a valuable tool for determining relative stress in deep, >1,220-m (>4,000-ft), underground pillars. If high-stress areas are detected, they can be destressed prior to development or they can be avoided. High-stress areas can be monitored with successive seismic surveys to determine if stress decreases to a level where development can be initiated safely. There are several benefits to using seismic tomography to identify high stress in deep underground pillars. The technique is reliable, cost-effective, efficient and noninvasive. Also, investigators can monitor large rock masses, as well as monitor pillars during the mining cycle. By identifying areas of high stress, engineers will be able to assure that miners are working in a safer environment.Spokane Research Center personnel have been investigating the use of seismic tomography to monitor the behavior of a rock mass, detect hazardous ground conditions and assess the mechanical integrity of a rock mass affected by mining. Seismic tomography can be a valuable tool for determining relative stress in deep, >1,200-m (>4,000-ft), underground pillars. If high-stress areas are detected, they can be destressed prior to development or they can be avoided. High-stress areas can be monitored with successive seismic surveys to determine if stress decreases to a level where development can be initiated safely. There are several benefits to using seismic tomography to identify high stress in deep underground pillars. The technique is reliable, cost-effective, efficient and noninvasive. Also, investigators can monitor large rock masses, as well as monitor pillars during the mining cycle. By identifying areas of high stress. engineers will be able to assure that miners are working in a safer environment.

Phase Grating Design for a Dual-Band Snapshot Imaging Spectrometer

NASA Astrophysics Data System (ADS)

Scholl, James F.; Dereniak, Eustace L.; Descour, Michael R.; Tebow, Christopher P.; Volin, Curtis E.

2003-01-01

Infrared spectral features have proved useful in the identification of threat objects. Dual-band focal-plane arrays (FPAs) have been developed in which each pixel consists of superimposed midwave and long-wave photodetectors [Dyer and Tidrow, Conference on Infrared Detectors and Focal Plane Arrays (SPIE, Bellingham, Wash., 1999), pp. 434 -440 . Combining dual-band FPAs with imaging spectrometers capable of interband hyperspectral resolution greatly improves spatial target discrimination. The computed-tomography imaging spectrometer (CTIS) ] [Descour and Dereniak, Appl. Opt. 34, 4817 -4826 (1995) has proved effective in producing hyperspectral images in a single spectral region. Coupling the CTIS with a dual-band detector can produce two hyperspectral data cubes simultaneously. We describe the design of two-dimensional, surface-relief, computer-generated hologram dispersers that permit image information in these two bands simultaneously.

Semiconductor@metal-organic framework core-shell heterostructures: a case of ZnO@ZIF-8 nanorods with selective photoelectrochemical response.

PubMed

Zhan, Wen-wen; Kuang, Qin; Zhou, Jian-zhang; Kong, Xiang-jian; Xie, Zhao-xiong; Zheng, Lan-sun

2013-02-06

Metal-organic frameworks (MOFs) and related material classes are attracting considerable attention for their applications in gas storage/separation as well as catalysis. In contrast, research concerning potential uses in electronic devices (such as sensors) is in its infancy, which might be due to a great challenge in the fabrication of MOFs and semiconductor composites with well-designed structures. In this paper, we proposed a simple self-template strategy to fabricate metal oxide semiconductor@MOF core-shell heterostructures, and successfully obtained freestanding ZnO@ZIF-8 nanorods as well as vertically standing arrays (including nanorod arrays and nanotube arrays). In this synthetic process, ZnO nanorods not only act as the template but also provide Zn(2+) ions for the formation of ZIF-8. In addition, we have demonstrated that solvent composition and reaction temperature are two crucial factors for successfully fabricating well-defined ZnO@ZIF-8 heterostructures. As we expect, the as-prepared ZnO@ZIF-8 nanorod arrays display distinct photoelectrochemical response to hole scavengers with different molecule sizes (e.g., H(2)O(2) and ascorbic acid) owing to the limitation of the aperture of the ZIF-8 shell. Excitingly, such ZnO@ZIF-8 nanorod arrays were successfully applied to the detection of H(2)O(2) in the presence of serous buffer solution. Therefore, it is reasonable to believe that the semiconductor@MOFs heterostructure potentially has promising applications in many electronic devices including sensors.

Graphene quantum dots-carbon nanotube hybrid arrays for supercapacitors

NASA Astrophysics Data System (ADS)

Hu, Yue; Zhao, Yang; Lu, Gewu; Chen, Nan; Zhang, Zhipan; Li, Hui; Shao, Huibo; Qu, Liangti

2013-05-01

Graphene quantum dots (GQDs) have been successfully deposited onto aligned carbon nanotubes (CNTs) by a benign electrochemical method and the capacitive properties of the as-formed GQD/CNT hybrid arrays were evaluated in symmetrical supercapacitors. It was found that supercapacitors fabricated from GQD/CNT hybrid arrays exhibited a high capacitance of 44 mF cm-2, representing a more than 200% improvement over that of bare CNT electrodes.

Graphene quantum dots-carbon nanotube hybrid arrays for supercapacitors.

PubMed

Hu, Yue; Zhao, Yang; Lu, Gewu; Chen, Nan; Zhang, Zhipan; Li, Hui; Shao, Huibo; Qu, Liangti

2013-05-17

Graphene quantum dots (GQDs) have been successfully deposited onto aligned carbon nanotubes (CNTs) by a benign electrochemical method and the capacitive properties of the as-formed GQD/CNT hybrid arrays were evaluated in symmetrical supercapacitors. It was found that supercapacitors fabricated from GQD/CNT hybrid arrays exhibited a high capacitance of 44 mF cm(-2), representing a more than 200% improvement over that of bare CNT electrodes.

Phased array antenna matching: Simulation and optimization of a planar phased array of circular waveguide elements

NASA Technical Reports Server (NTRS)

Dudgeon, J. E.

1972-01-01

A computerized simulation of a planar phased array of circular waveguide elements is reported using mutual coupling and wide angle impedance matching in phased arrays. Special emphasis is given to circular polarization. The aforementioned computer program has as variable inputs: frequency, polarization, grid geometry, element size, dielectric waveguide fill, dielectric plugs in the waveguide for impedance matching, and dielectric sheets covering the array surface for the purpose of wide angle impedance matching. Parameter combinations are found which produce reflection peaks interior to grating lobes, while dielectric cover sheets are successfully employed to extend the usable scan range of a phased array. The most exciting results came from the application of computer aided optimization techniques to the design of this type of array.

Development of Fuses for Protection of Geiger-Mode Avalanche Photodiode Arrays

NASA Astrophysics Data System (ADS)

Grzesik, Michael; Bailey, Robert; Mahan, Joe; Ampe, Jim

2015-11-01

Current-limiting fuses composed of Ti/Al/Ni were developed for use in Geiger-mode avalanche photodiode arrays for each individual pixel in the array. The fuses were designed to burn out at ˜4.5 × 10-3 A and maintain post-burnout leakage currents less than 10-7 A at 70 V sustained for several minutes. Experimental fuse data are presented and successful incorporation of the fuses into a 256 × 64 pixel InP-based Geiger-mode avalanche photodiode array is reported.

Low-background detector arrays for infrared astronomy

NASA Technical Reports Server (NTRS)

Mccreight, C. R.; Estrada, J. A.; Goebel, J. H.; Mckelvey, M. E.; Mckibbin, D. D.; Mcmurray, R. E., Jr.; Weber, T. T.

1989-01-01

The status of a program which develops and characterizes integrated infrared (IR) detector array technology for space astronomical applications is described. The devices under development include intrinsic, extrinsic silicon, and extrinsic germanium detectors, coupled to silicon readout electronics. Low-background laboratory test results include measurements of responsivity, noise, dark current, temporal response, and the effects of gamma-radiation. In addition, successful astronomical imagery has been obtained on some arrays from this program. These two aspects of the development combine to demonstrate the strong potential for integrated array technology for IR space astronomy.

Unenhanced Cone Beam Computed Tomography and Fusion Imaging in Direct Percutaneous Sac Injection for Treatment of Type II Endoleak: Technical Note

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carrafiello, Gianpaolo, E-mail: gcarraf@gmail.com; Ierardi, Anna Maria; Radaelli, Alessandro

AimTo evaluate safety, feasibility, technical success, and clinical success of direct percutaneous sac injection (DPSI) for the treatment of type II endoleaks (T2EL) using anatomical landmarks on cone beam computed tomography (CBCT) and fusion imaging (FI).Materials and MethodsEight patients with T2EL were treated with DPSI using CBCT as imaging guidance. Anatomical landmarks on unenhanced CBCT were used for referencing T2EL location in the first five patients, while FI between unenhanced CBCT and pre-procedural computed tomography angiography (CTA) was used in the remaining three patients. Embolization was performed with thrombin, glue, and ethylene–vinyl alcohol copolymer. Technical and clinical success, iodinated contrastmore » utilization, procedural time, fluoroscopy time, and mean radiation dose were registered.ResultsDPSI was technically successful in all patients: the needle was correctly positioned at the first attempt in six patients, while in two of the first five patients the needle was repositioned once. Neither minor nor major complications were registered. Average procedural time was 45 min and the average administered iodinated contrast was 13 ml. Mean radiation dose of the procedure was 60.43 Gy cm{sup 2} and mean fluoroscopy time was 18 min. Clinical success was achieved in all patients (mean follow-up of 36 months): no sign of T2EL was reported in seven patients until last CT follow-up, while it persisted in one patient with stability of sac diameter.ConclusionsDPSI using unenhanced CBCT and FI is feasible and provides the interventional radiologist with an accurate and safe alternative to endovascular treatment with limited iodinated contrast utilization.« less

Partially coherent lensfree tomographic microscopy⋄

PubMed Central

Isikman, Serhan O.; Bishara, Waheb; Ozcan, Aydogan

2012-01-01

Optical sectioning of biological specimens provides detailed volumetric information regarding their internal structure. To provide a complementary approach to existing three-dimensional (3D) microscopy modalities, we have recently demonstrated lensfree optical tomography that offers high-throughput imaging within a compact and simple platform. In this approach, in-line holograms of objects at different angles of partially coherent illumination are recorded using a digital sensor-array, which enables computing pixel super-resolved tomographic images of the specimen. This imaging modality, which forms the focus of this review, offers micrometer-scale 3D resolution over large imaging volumes of, for example, 10–15 mm3, and can be assembled in light weight and compact architectures. Therefore, lensfree optical tomography might be particularly useful for lab-on-a-chip applications as well as for microscopy needs in resource-limited settings. PMID:22193016

ViRPET--combination of virtual reality and PET brain imaging

DOEpatents

Majewski, Stanislaw; Brefczynski-Lewis, Julie

2017-05-23

Various methods, systems and apparatus are provided for brain imaging during virtual reality stimulation. In one example, among others, a system for virtual ambulatory environment brain imaging includes a mobile brain imager configured to obtain positron emission tomography (PET) scans of a subject in motion, and a virtual reality (VR) system configured to provide one or more stimuli to the subject during the PET scans. In another example, a method for virtual ambulatory environment brain imaging includes providing stimulation to a subject through a virtual reality (VR) system; and obtaining a positron emission tomography (PET) scan of the subject while moving in response to the stimulation from the VR system. The mobile brain imager can be positioned on the subject with an array of imaging photodetector modules distributed about the head of the subject.

Tomographic methods in flow diagnostics

NASA Technical Reports Server (NTRS)

Decker, Arthur J.

1993-01-01

This report presents a viewpoint of tomography that should be well adapted to currently available optical measurement technology as well as the needs of computational and experimental fluid dynamists. The goals in mind are to record data with the fastest optical array sensors; process the data with the fastest parallel processing technology available for small computers; and generate results for both experimental and theoretical data. An in-depth example treats interferometric data as it might be recorded in an aeronautics test facility, but the results are applicable whenever fluid properties are to be measured or applied from projections of those properties. The paper discusses both computed and neural net calibration tomography. The report also contains an overview of key definitions and computational methods, key references, computational problems such as ill-posedness, artifacts, missing data, and some possible and current research topics.

Improved event positioning in a gamma ray detector using an iterative position-weighted centre-of-gravity algorithm.

PubMed

Liu, Chen-Yi; Goertzen, Andrew L

2013-07-21

An iterative position-weighted centre-of-gravity algorithm was developed and tested for positioning events in a silicon photomultiplier (SiPM)-based scintillation detector for positron emission tomography. The algorithm used a Gaussian-based weighting function centred at the current estimate of the event location. The algorithm was applied to the signals from a 4 × 4 array of SiPM detectors that used individual channel readout and a LYSO:Ce scintillator array. Three scintillator array configurations were tested: single layer with 3.17 mm crystal pitch, matched to the SiPM size; single layer with 1.5 mm crystal pitch; and dual layer with 1.67 mm crystal pitch and a ½ crystal offset in the X and Y directions between the two layers. The flood histograms generated by this algorithm were shown to be superior to those generated by the standard centre of gravity. The width of the Gaussian weighting function of the algorithm was optimized for different scintillator array setups. The optimal width of the Gaussian curve was found to depend on the amount of light spread. The algorithm required less than 20 iterations to calculate the position of an event. The rapid convergence of this algorithm will readily allow for implementation on a front-end detector processing field programmable gate array for use in improved real-time event positioning and identification.

The IberArray BB seismic network of Topo-Iberia: new constraints revealing the deep structure of the Iberian Peninsula and North Morocco

NASA Astrophysics Data System (ADS)

Gallart, J.; Diaz Cusi, J.; Villasenor, A.; Mancilla, F. D. L.; Bonatto, L.; Schimmel, M.; El moudnib, L.

2014-12-01

Topo-Iberia has been a large-scale Spanish project running from 2007 to 2013 that integrated more than 150 researchers on Earth Sciences. One of its key assets was the management of an observatory platform, named IberArray, aimed to provide new geophysical datasets (seismic, GPS, MT) to constrain the structure of Iberia with unprecedented resolution. The IberArray seismic pool was composed by 70+ BB stations, covering the study area in 3 deployments with a site-density of 60km x 60km. The data base holds ~300 sites, including the permanent networks in the area. Hence it forms a unique seismic database in Europe that allow for multiple analyses to constrain the complex geodinamics of the Western Mediterranean. A summary of new results coming from different techniques is presented here. The SKS splitting analysis has provided a spectacular image of the rotation of the fast velocity direction along the Gibraltar Arc. In central and northern Iberia, the fast polarization directions are close to EW, consistently with global mantle flow models considering contributions of surface plate motion, density variations and net lithosphere rotation. Those results suggest an asthenospheric origin of the observed anisotropy related to present-day mantle flow. Receiver functions have revealed the crustal thickness variations beneath the Rif and southern Iberia, including a crustal root beneath the Rif. The Variscan Iberian massif shows a flat Moho discontinuity, while the areas reworked in the Alpine orogeny show a slightly thicker crust. Beneath N Iberia, the imbrication of the Iberian and Eurasian crusts results in complex receiver functions. Depths exceeding 45 km are observed along the Pyrenean range, while the crust thins to values of 26-28 km close to the Atlantic coasts. The geometry of the 410-km and 660-km discontinuities has been investigated using novel cross-correlation/stacking techniques. Ambient noise tomography allows to identify the main sedimentary basins and to discriminate between the Variscan and the Alpine reworked areas. Local body-wave tomography in North Morocco has improved the location of the small magnitude events on the area and the details of the crustal structure. Teleseismic tomography has confirmed, using an independent data set, the presence of a high-velocity slab beneath the Gibraltar Arc.

High-resolution Teleseismic Tomography Reveals a Complex Lithospheric Structure Beneath the North Anatolian Fault

NASA Astrophysics Data System (ADS)

Papaleo, E.; Cornwell, D. G.; Rawlinson, N.

2016-12-01

We present high-resolution tomography images of a major active continental strike slip fault zone, the North Anatolian Fault (NAF) in northern Turkey. Historical seismic records show that the NAF, with a length of 1500 km and a current slip rate of 25 mm/yr, is capable of producing large magnitude earthquakes that have activated different segments of the fault in a westward progression towards the study region, where the devastating Izmit and Düzce events occurred in 1999. The NAF poses a major seismic hazard to the city of Istanbul, situated close to one of the two strands into which the fault splays east of the Sea of Marmara. In order to improve our understanding of the lower crust and upper mantle properties that influence fault dynamics throughout the seismic cycle, we constrain NAF structure across the Moho in unprecedented detail by applying teleseismic tomography to data recorded by an array of 70 temporary seismic stations deployed with 7 km spacing (Dense Array for North Anatolia, DANA). High quality recordings of teleseismic earthquakes combined with the dense nature of the array allow high-resolution (i.e. horizontal and vertical resolution of 8 and 15 km, respectively) 3D seismic imaging of the velocity structure beneath the NAF. The northern branch of the NAF coincides with an abrupt change between opposite polarity velocity anomalies and can be traced to at least Moho depths ( 36 km) with a width of ≤8 km. A similar pattern of antithetic anomalies occurs over a horizontal distance of 30-50 km below the Moho and may indicate a widening shear zone as it passes from the crust into the upper mantle. We find evidence for significant along-strike variation in NAF structure over distances of ≤20 km and interpret an east-to-west narrowing of upper mantle slow velocity anomalies (from 50 to 30 km) to represent laterally variable strain focussing within the lithosphere. Our observations are consistent with the notion that the NAF marks the boundary between compositionally distinct lithospheres with different tectonic histories and reactivates the pre-existing Intra-Pontide suture zone. We discuss our results in terms of the influence of lithosphere heterogeneity on the development and evolution of global continental strike-slip fault zones and assess the applicability of current shear zone deformation models.

Preliminary results of the Source China Sea passive source OBS array experiment

NASA Astrophysics Data System (ADS)

Yang, T.; Liu, C.; Pei, Y.; Xia, S.

2013-12-01

The Scarborough, or Huangyan, Seamount chain in South China Sea (SCS) represents an extreme case of the global mid-ocean ridge system where the magmatism continues for many million years after the cessation of spreading. To understand this unique process, the South China Sea Deep (SCSD) program funded an experiment deploying a passive source OBS array to image the lithospheric structure beneath the extinct ridge. In April 2012, 18 passive source OBSs, including 15 Guralp CMG-40T OBS and 3 I-4C OBS, were deployed around the Huangyan Island for one year. 11 OBSs were successfully recovered this April, and their data are being processed. Here we present some preliminary results from analyses of this dataset, including the general quality of three-component seismograms, characteristics of seafloor ambient noise spectra, determining the OBS orientation from the Rayleigh wave polarization, and the dispersion analysis of Rayleigh waves. We found that, for most stations, seismograms from teleseismic, regional and local events are generally good with the horizontal records being comparable with vertical component. The noise levels in these seafloor stations are much higher than land-based stations, especially in shorter periods, likely suggesting the direct and stronger impact from the tempestuous SCS. Applications of more sophisticated seismic techniques such as surface wave tomography, seismic anisotropy, receiver function and ambient noise cross-correlation are underway. In addition to the low recovery rate, there are other lessons learned from this experiment. For example, at least two stations have detectable timing problems; Airgun shots should have been used to constrain the timings and orientations in both deployment and recovery. It is still challenging and costly to carry out long-term passive source seismic observations in deep sea.

Development of Hybrid Sensor Arrays for Sensor Arrays for Simultaneous Measurement of Pressure and Shear Stress Distribution

NASA Technical Reports Server (NTRS)

2000-01-01

This document reports on the progress in developing hybrid sensors for the simultaneous measurement of pressure and shear stress. The key feature for the success of the proposed hybrid sensor array is the ability to deposit Cu-Ni alloy with proper composition (55 - 45) on a silicon wafer to form a strain gage. This alloy strain gage replaces the normally used Si strain gages in MEMS, which are highly nonlinear and temperature dependent. The copper nickel, with proper composition (55 - 45), was successfully deposited on a silicon wafer with a few trials during this period of the project. Pictures of the Cu-Ni alloy strain gage and the x-ray spectra indicating the composition are shown. The planned tests are also reviewed.

Preparation of superhydrophobic copper surface by a novel silk-screen printing aided electrochemical machining method

NASA Astrophysics Data System (ADS)

Yan, X. Y.; Chen, G. X.; Liu, J. W.

2018-03-01

A kind of superhydrophobic copper surface with micro-nanocomposite structure has been successfully fabricated by employing a silk-screen printing aided electrochemical machining method. At first silk-screen printing technology has been used to form a column point array mask, and then the microcolumn array would be fabricated by electrochemical machining (ECM) effect. In this study, the drop contact angles have been studied and scanning electron microscopy (SEM) has been used to study the surface characteristic of the workpiece. The experiment results show that the micro-nanocomposite structure with cylindrical array can be successfully fabricated on the metal surface. And the maximum contact angle is 151° when the fluoroalkylsilane ethanol solution was used to modify the machined surface in this study.

Development of a ninety string solar array simulator

NASA Technical Reports Server (NTRS)

Vasek, Thomas E.; Birchenough, Arthur G.

1991-01-01

A power source was developed to support testing for the Space Station Freedom Power Management and Distribution (PMAD) DC Testbed. The intent was to simulate as closely as possible the steady-state and transient responses of a solar array. Several breadboards and one thermal prototype were built and tested. Responses were successfully verified and improved upon during successive breadboards. The completed 90-string simulator consists of four power MOSFETs, four 25 watt source resistors, and four 250 watt drain source bypass resistors per string, in addition to the control circuitry.

Differential phase microscope and micro-tomography with a Foucault knife-edge scanning filter

NASA Astrophysics Data System (ADS)

Watanabe, N.; Hashizume, J.; Goto, M.; Yamaguchi, M.; Tsujimura, T.; Aoki, S.

2013-10-01

An x-ray differential phase microscope with a Foucault knife-edge scanning filter was set up at the bending magnet source BL3C, Photon Factory. A reconstructed phase profile from the differential phase image of an aluminium wire at 5.36 keV was fairly good agreement with the numerical simulation. Phase tomography of a biological specimen, such as an Artemia cyst, could be successfully demonstrated.

Management of geminated maxillary lateral incisor using cone beam computed tomography as a diagnostic tool.

PubMed

James, Elizabeth Prabha; Johns, Dexton Antony; Johnson, Ki; Maroli, Ramesh Kumar

2014-05-01

Geminated teeth are consequences of developmental anomalies leading to joined elements, due to incomplete attempt of one tooth germ to divide into two. This case report describes successful endodontic treatment of an unaesthetic geminated permanent maxillary lateral incisor tooth and its esthetic rehabilitation using all ceramic crowns. Newer imaging technique like cone beam computed tomography was taken for the better understanding of the complicated root canal morphology.

Non-stimulated adrenal venous sampling using Dyna computed tomography in patients with primary aldosteronism

PubMed Central

Chang, Chin-Chen; Lee, Bo-Ching; Liu, Kao-Lang; Chang, Yeun-Chung; Wu, Vin-Cent; Huang, Kuo-How

2016-01-01

In this retrospective study, we aimed to examine the effect of applying Dyna computed tomography (CT) on the success rate of adrenal venous sampling (AVS) without adrenocorticotropic hormone stimulation. A total of 100 consecutive patients with primary aldosteronism who underwent AVS between May 2012 and July 2015 were enrolled. In all the cases, Dyna CT was used in AVS to validate catheter position in the right adrenal vein. A selectivity index (cortisoladrenal vein /cortisolinferior vena cava) of ≥2.0 of both adrenal veins were required for successful AVS. Dyna CT indicated misplaced catheters in 16 patients; of these patients, 75% (12/16) eventually had successful right AVS after catheter repositioning. The success rate of initial sampling at the right adrenal vein was 76% (76/100), which increased to 88% (88/100) after Dyna CT was applied (p < 0.001). The most common inadvertently catheterised vessels detected using Dyna CT were the accessory hepatic veins (56.3%, 9/16), followed by the renal capsular veins (37.5%, 6/16). The overall success rate of non-stimulated AVS using Dyna CT was 87% (87/100). Thus, the application of Dyna CT further increased the success rate of non-stimulated AVS. PMID:27876824

"Successful" Principals: A Contested Notion for Superintendents and Principals

ERIC Educational Resources Information Center

Scribner, Samantha M. Paredes; Crow, Gary M.; Lopez, Gerardo R.; Murtadha, Khaula

2011-01-01

The notion of "success" is narrowly defined and appropriated within an educational context. Typically limited to objective measures of organizational productivity, effectiveness, and efficiency, "successful" principal practices, we argue, engender action and attention to a broader array of issues and interrelationships. In this study, we conducted…

Invasive Electrical Impedance Tomography for Blood Vessel Detection

PubMed Central

Martinsen, Ørjan G.; Kalvøy, Håvard; Grimnes, Sverre; Nordbotten, Bernt; Hol, Per Kristian; Fosse, Erik; Myklebust, Helge; Becker, Lance B

2010-01-01

We present a novel method for localization of large blood vessels using a bioimpedance based needle positioning system on an array of ten monopolar needle electrodes. The purpose of the study is to develop a portable, low cost tool for rapid vascular access for cooling and controlled reperfusion of cardiac arrest patients. Preliminary results show that localization of blood vessels is feasible with this method, but larger studies are necessary to improve the technology. PMID:21611140

[Application of array-based comparative genomic hybridization technique in genetic analysis of patients with spontaneous abortion].

PubMed

Chu, Y; Wu, D; Hou, Q F; Huo, X D; Gao, Y; Wang, T; Wang, H D; Yang, Y L; Liao, S X

2016-08-25

To investigate the value of array-based comparative genomic hybridization (array-CGH) technique for the detection of chromosomal analysis of miscarried embryo, and to provide genetic counseling for couples with spontaneous abortion. Totally 382 patients who underwent miscarriage were enrolled in this study. All aborted tissues were analyzed with conventional cytogenetic karyotyping and array-CGH, respectively. Through genetic analysis, all of the 382 specimens were successfully analyzed by array-CGH (100.0%, 382/382), and the detection rate of chromosomal aberrations was 46.6% (178/382). However, conventional karyotype analysis was successfully performed in 281 cases (73.6%, 281/382), and 113 (40.2%, 113/281) were found with chromosomal aberrations. Of these 178 samples identified by array-CGH, 163 samples (91.6%, 163/178) were aneuploidy, 15 samples (8.4%, 15/178) were segmental deletion and (or) duplication cases. Four of 10 cases with small segmental deletion and duplication were validated to be transferred from their fathers or mathers who were carriers of submicroscopic reciprocal translocation. Of these 113 abnormal karyotypes founded by conventional karyotyping, 108 cases (95.6%, 108/113) were aneuploidy and 5 cases (4.4%, 5/113) had chromosome structural aberrations. Most array-CGH results were consistent with conventional karyotyping but with 3 cases of discrepancy, which included 2 cases of triploids, 1 case of low-level mosaicism that undetcted by array-CGH. Compared with conventional karyotyping, there is an increased detection rate of chromosomal abnormalities when array-CGH is used to analyse the products of conception, primarilly because of its sucess with nonviable tissues. It could be a first-line method to determine the reason of miscarrage with higher accuracy and sensitivity.

Phased Array Beamforming and Imaging in Composite Laminates Using Guided Waves

NASA Technical Reports Server (NTRS)

Tian, Zhenhua; Leckey, Cara A. C.; Yu, Lingyu

2016-01-01

This paper presents the phased array beamforming and imaging using guided waves in anisotropic composite laminates. A generic phased array beamforming formula is presented, based on the classic delay-and-sum principle. The generic formula considers direction-dependent guided wave properties induced by the anisotropic material properties of composites. Moreover, the array beamforming and imaging are performed in frequency domain where the guided wave dispersion effect has been considered. The presented phased array method is implemented with a non-contact scanning laser Doppler vibrometer (SLDV) to detect multiple defects at different locations in an anisotropic composite plate. The array is constructed of scan points in a small area rapidly scanned by the SLDV. Using the phased array method, multiple defects at different locations are successfully detected. Our study shows that the guided wave phased array method is a potential effective method for rapid inspection of large composite structures.

Delamination Detection Using Guided Wave Phased Arrays

NASA Technical Reports Server (NTRS)

Tian, Zhenhua; Yu, Lingyu; Leckey, Cara

2016-01-01

This paper presents a method for detecting multiple delaminations in composite laminates using non-contact phased arrays. The phased arrays are implemented with a non-contact scanning laser Doppler vibrometer (SLDV). The array imaging algorithm is performed in the frequency domain where both the guided wave dispersion effect and direction dependent wave properties are considered. By using the non-contact SLDV array with a frequency domain imaging algorithm, an intensity image of the composite plate can be generated for delamination detection. For the proof of concept, a laboratory test is performed using a non-contact phased array to detect two delaminations (created through quasi-static impact test) at different locations in a composite plate. Using the non-contact phased array and frequency domain imaging, the two impact-induced delaminations are successfully detected. This study shows that the non-contact phased array method is a potentially effective method for rapid delamination inspection in large composite structures.

A report on an acute, in-hours, outpatient review clinic with ultrasonography facilities for the early evaluation of general surgical patients.

PubMed

Pidgeon, T E; Shariff, U; Devine, F; Menon, V

2016-09-01

Introduction In 2013 our hospital introduced an in-hours, consultant-led, outpatient acute surgical clinic (ASC) for emergency general surgical patients. In 2014 this clinic was equipped with a dedicated ultrasonography service. This prospective cohort study evaluated this service before and after the introduction of ultrasonography facilities. Methods Data were recorded prospectively for all patients attending the clinic during 2013 and 2014. The primary outcome was patient destination (whether there was follow-up/admission) after clinic attendance. Results The ASC reviewed patients with a wide age range and array of general surgical complaints. In 2013, 186 patients attended the ASC. After the introduction of the ultrasonography service in 2014, 304 patients attended. In 2014, there was a reduction in the proportion of patients admitted to hospital from the clinic (18.3% vs 8.9%, p=0.002). However, the proportion of patients discharged after ASC review remained comparable with 2013 (30.1% in 2013 vs 38.8% in 2014, p=0.051). The proportion of patients undergoing computed tomography (CT) scans also fell (14.0% vs 4.9%, p<0.001). Conclusions The ASC assessed a wide array of general surgical complaints. Only a small proportion required hospital admission. The introduction of an ultrasonography service was associated with a further reduction in admission rates and computed tomography.

Use of computed tomography to predict the outcome of a noninvasive intranasal infusion in dogs with nasal aspergillosis

PubMed Central

Saunders, Jimmy H.; Duchateau, Luc; Störk, Christophe; van Bree, Henri

2003-01-01

Computed tomography (CT) was performed on 36 dogs with nasal aspergillosis to assess whether this imaging technique can be used to predict the success of a noninvasive intranasal infusion of enilconazole. A CT score based on the severity of the disease was given to each dog, prior to treatment, by dividing the nasal cavities and frontal sinuses into 8 anatomical regions. After therapy, the dogs were classified into 2 response groups (success group: dogs cured after 1 treatment; failure group: dogs needing more than 1 treatment or with treatment failure). No significant relationship on the logistic scale was found between the CT score and the response to treatment. High sensitivity (treatment failures correctly predicted) and specificity (treatment successes correctly predicted) could not be obtained at the same time, whatever the cut-off value chosen. The results of this study suggest that CT cannot predict the therapeutic success of nasal aspergillosis in dogs treated with a 1-hour infusion of enilconazole. However, dogs with a low score seem to be good candidates to respond after 1 treatment. PMID:12715982

Applying LED in full-field optical coherence tomography for gastrointestinal endoscopy

NASA Astrophysics Data System (ADS)

Yang, Bor-Wen; Wang, Yu-Yen; Juan, Yu-Shan; Hsu, Sheng-Jie

2015-08-01

Optical coherence tomography (OCT) has become an important medical imaging technology due to its non-invasiveness and high resolution. Full-field optical coherence tomography (FF-OCT) is a scanning scheme especially suitable for en face imaging as it employs a CMOS/CCD device for parallel pixels processing. FF-OCT can also be applied to high-speed endoscopic imaging. Applying cylindrical scanning and a right-angle prism, we successfully obtained a 360° tomography of the inner wall of an intestinal cavity through an FF-OCT system with an LED source. The 10-μm scale resolution enables the early detection of gastrointestinal lesions, which can increase detection rates for esophageal, stomach, or vaginal cancer. All devices used in this system can be integrated by MOEMS technology to contribute to the studies of gastrointestinal medicine and advanced endoscopy technology.

Targeted cell adhesion on selectively micropatterned polymer arrays on a poly(dimethylsiloxane) surface.

PubMed

Tang, Linzhi; Min, Junhong; Lee, Eun-Cheol; Kim, Jong Sung; Lee, Nae Yoon

2010-02-01

Herein, we introduce the fabrication of polymer micropattern arrays on a chemically inert poly(dimethylsiloxane) (PDMS) surface and employ them for the selective adhesion of cells. To fabricate the micropattern arrays, a mercapto-ester-based photocurable adhesive was coated onto a mercaptosilane-coated PDMS surface and photopolymerized using a photomask to obtain patterned arrays at the microscale level. Robust polymer patterns, 380 microm in diameter, were successfully fabricated onto a PDMS surface, and cells were selectively targeted toward the patterned regions. Next, the performance of the cell adhesion was observed by anchoring cell adhesive linker, an RGD oligopeptide, on the surface of the mercapto-ester-based adhesive-cured layer. The successful anchoring of the RGD linker was confirmed through various surface characterizations such as water contact angle measurement, XPS analysis, FT-IR analysis, and AFM measurement. The micropatterning of a photocurable adhesive onto a PDMS surface can provide high structural rigidity, a highly-adhesive surface, and a physical pathway for selective cell adhesion, while the incorporated polymer micropattern arrays inside a PDMS microfluidic device can serve as a microfluidic platform for disease diagnoses and high-throughput drug screening.

Advanced photovoltaic solar array design assessment

NASA Technical Reports Server (NTRS)

Stella, Paul; Scott-Monck, John

1987-01-01

The Advanced Photovoltaic Solar Array (APSA) program seeks to bring to flight readiness a solar array that effectively doubles the specific power of the Solar Array Flight Experiment/Solar Electric Propulsion (SAFE/SEP) design that was successfully demonstrated during the Shuttle 41-D mission. APSA is a critical intermediate milestone in the effort to demonstrate solar array technologies capable of 300 W/kg and 300 W/square m at beginning of life (BOL). It is not unreasonable to anticipate the development of solar array designs capable of 300 W/kg at BOL for operational power levels approx. greater than 25 kW sub e. It is also quite reasonable to expect that high performance solar arrays capable of providing at least 200 W/kg at end of life for most orbits now being considered by mission planners will be realized in the next decade.

Reconstructing the Auditory Apparatus of Therapsids by Means of Neutron Tomography

NASA Astrophysics Data System (ADS)

Laaß, Michael; Schillinger, Burkhard

The internal cranial structure of mammalian ancestors, i.e. the therapsids or ;mammal-like reptiles;, is crucial for understanding the early mammalian evolution. In the past therapsid skulls were investigated by mechanical sectioning or serial grinding, which was a very time-consuming and destructive process and could only be applied to non-valuable or poorly preserved specimens. As most therapsid skulls are embedded in terrestrial iron-rich sediments of Late Permian or Triassic age, i.e. so called ;Red beds;, a successful investigation with X-Rays is often not possible. We successfully investigated therapsid skulls by means of neutron tomography at the facility ANTARES at FRM II in Munich using cold neutron radiation. This kind of radiation is able to penetrate iron-rich substances in the range between 5 and 15 cm and produces a good contrast between matrix and bones, which enables segmentation of internal cranial structures such as bones, cavities and canals of nerves and blood vessels. In particular, neutron tomography combined with methods of 3D modeling was used here for the investigation and reconstruction of the auditory apparatus of therapsids.

Imaging San Jacinto Fault damage zone structure using dense linear arrays: application of ambient noise tomography, Rayleigh wave ellipticity, and site amplification

NASA Astrophysics Data System (ADS)

Wang, Y.; Lin, F. C.; Allam, A. A.; Ben-Zion, Y.

2017-12-01

The San Jacinto fault is presently the most seismically active component of the San Andreas Transform system in Southern California. To study the damage zone structure, two dense linear geophone arrays (BS and RR) were deployed across the Clark segment of the San Jacinto Fault between Anza and Hemet during winter 2015 and Fall 2016, respectively. Both arrays were 2 km long with 20 m station spacing. Month-long three-component ambient seismic noise data were recorded and used to calculate multi-channel cross-correlation functions. All three-component noise records of each array were normalized simultaneously to retain relative amplitude information between different stations and different components. We observed clear Rayleigh waves and Love waves on the cross-correlations of both arrays at 0.3 - 1 s period. The phase travel times of the Rayleigh waves on both arrays were measured by frequency-time analysis (FTAN), and inverted for Rayleigh wave phase velocity profiles of the upper 500 m depth. For both arrays, we observe prominent asymmetric low velocity zones which narrow with depth. At the BS array near the Hemet Stepover, an approximately 250m wide slow zone is observed to be offset by 75m to the northeast of the surface fault trace. At the RR array near the Anza segment of the fault, a similar low velocity zone width and offset are observed, along with a 10% across-fault velocity contrast. Analyses of Rayleigh wave ellipticity (H/V ratio), Love wave phase travel times, and site amplification are in progress. By using multiple measurements from ambient noise cross-correlations, we can obtain strong constraints on the local damage zone structure of the San Jacinto Fault. The results contribute to improved understanding of rupture directivity, maximum earthquake magnitude and more generally seismic hazard associated with the San Jacinto fault zone.

Performance evaluation of a conformal thermal monitoring sheet (TMS) sensor array for measurement of surface temperature distributions during superficial hyperthermia treatments

PubMed Central

Arunachalam, K.; Maccarini, P.; Juang, T.; Gaeta, C.; Stauffer, P. R.

2009-01-01

Purpose This paper presents a novel conformal thermal monitoring sheet sensor array with differential thermal sensitivity for measuring temperature distributions over large surface areas. Performance of the sensor array is evaluated in terms of thermal accuracy, mechanical stability and conformity to contoured surfaces, probe self heating under irradiation from microwave and ultrasound hyperthermia sources, and electromagnetic field perturbation. Materials and Methods A prototype TMS with 4×4 array of fiberoptic sensors embedded between two flexible and thermally conducting polyimide films was developed as an alternative to the standard 1-2 mm diameter plastic catheter based probes used in clinical hyperthermia. Computed tomography images and bending tests were performed to evaluate the conformability and mechanical stability respectively. Irradiation and thermal barrier tests were conducted and thermal response of the prototype was compared with round cross-sectional clinical probes. Results Bending and conformity tests demonstrated higher flexibility, dimensional stability and close conformity to human torso. Minimal perturbation of microwave fields and low probe self heating was observed when irradiated with 915MHz microwave and 3.4MHz ultrasound sources. The transient and steady state thermal responses of the TMS array were superior compared to the clinical probes. Conclusions A conformal TMS sensor array with improved thermal sensitivity and dimensional stability was investigated for real-time skin temperature monitoring. This fixed-geometry, body-conforming array of thermal sensors allows fast and accurate characterization of two-dimensional temperature distributions over large surface areas. The prototype TMS demonstrates significant advantages over clinical probes for characterizing skin temperature distributions during hyperthermia treatments of superficial tissue disease. PMID:18465416

Testing of a novel pin array guide for accurate three-dimensional glenoid component positioning.

PubMed

Lewis, Gregory S; Stevens, Nicole M; Armstrong, April D

2015-12-01

A substantial challenge in total shoulder replacement is accurate positioning and alignment of the glenoid component. This challenge arises from limited intraoperative exposure and complex arthritic-driven deformity. We describe a novel pin array guide and method for patient-specific guiding of the glenoid central drill hole. We also experimentally tested the hypothesis that this method would reduce errors in version and inclination compared with 2 traditional methods. Polymer models of glenoids were created from computed tomography scans from 9 arthritic patients. Each 3-dimensional (3D) printed scapula was shrouded to simulate the operative situation. Three different methods for central drill alignment were tested, all with the target orientation of 5° retroversion and 0° inclination: no assistance, assistance by preoperative 3D imaging, and assistance by the pin array guide. Version and inclination errors of the drill line were compared. Version errors using the pin array guide (3° ± 2°) were significantly lower than version errors associated with no assistance (9° ± 7°) and preoperative 3D imaging (8° ± 6°). Inclination errors were also significantly lower using the pin array guide compared with no assistance. The new pin array guide substantially reduced errors in orientation of the central drill line. The guide method is patient specific but does not require rapid prototyping and instead uses adjustments to an array of pins based on automated software calculations. This method may ultimately provide a cost-effective solution enabling surgeons to obtain accurate orientation of the glenoid. Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Fast Neutron Emission Tomography of Used Nuclear Fuel Assemblies

NASA Astrophysics Data System (ADS)

Hausladen, Paul; Iyengar, Anagha; Fabris, Lorenzo; Yang, Jinan; Hu, Jianwei; Blackston, Matthew

2017-09-01

Oak Ridge National Laboratory is developing a new capability to perform passive fast neutron emission tomography of spent nuclear fuel assemblies for the purpose of verifying their integrity for international safeguards applications. Most of the world's plutonium is contained in spent nuclear fuel, so it is desirable to detect the diversion of irradiated fuel rods from an assembly prior to its transfer to ``difficult to access'' storage, such as a dry cask or permanent repository, where re-verification is practically impossible. Nuclear fuel assemblies typically consist of an array of fuel rods that, depending on exposure in the reactor and consequent ingrowth of 244Cm, are spontaneous sources of as many as 109 neutrons s-1. Neutron emission tomography uses collimation to isolate neutron activity along ``lines of response'' through the assembly and, by combining many collimated views through the object, mathematically extracts the neutron emission from each fuel rod. This technique, by combining the use of fast neutrons -which can penetrate the entire fuel assembly -and computed tomography, is capable of detecting vacancies or substitutions of individual fuel rods. This paper will report on the physics design and component testing of the imaging system. This material is based upon work supported by the U.S. Department of Energy, Office of Defense Nuclear Nonproliferation Research and Development within the National Nuclear Security Administration, under Contract Number DE-AC05-00OR22725.

Electronic hardware design of electrical capacitance tomography systems.

PubMed

Saied, I; Meribout, M

2016-06-28

Electrical tomography techniques for process imaging are very prominent for industrial applications, such as the oil and gas industry and chemical refineries, owing to their ability to provide the flow regime of a flowing fluid within a relatively high throughput. Among the various techniques, electrical capacitance tomography (ECT) is gaining popularity due to its non-invasive nature and its capability to differentiate between different phases based on their permittivity distribution. In recent years, several hardware designs have been provided for ECT systems that have improved its resolution of measurements to be around attofarads (aF, 10(-18) F), or the number of channels, that is required to be large for some applications that require a significant amount of data. In terms of image acquisition time, some recent systems could achieve a throughput of a few hundred frames per second, while data processing time could be achieved in only a few milliseconds per frame. This paper outlines the concept and main features of the most recent front-end and back-end electronic circuits dedicated for ECT systems. In this paper, multiple-excitation capacitance polling, a front-end electronic technique, shows promising results for ECT systems to acquire fast data acquisition speeds. A highly parallel field-programmable gate array (FPGA) based architecture for a fast reconstruction algorithm is also described. This article is part of the themed issue 'Supersensing through industrial process tomography'. © 2016 The Author(s).

A SNP genotyping array for hexaploid oat

USDA-ARS?s Scientific Manuscript database

Recognizing a need in cultivated hexaploid oat (Avena sativa L.) for a reliable set of reference SNPs, we have developed a 6K BeadChip design containing 257 Infinium I and 5,486 Infinium II designs corresponding to 5,743 SNPs. Of those, 4,975 SNPs yielded successful assays after array manufacturing...

The Solar Anomalous and Magnetospheric Particle Explorer (SAMPEX) yo-yo despin and solar array deployment mechanism

NASA Technical Reports Server (NTRS)

Kellogg, James W.

1993-01-01

The SAMPEX spacecraft, successfully launched in July 1992, carried a yo-yo despin system and deployable solar arrays. The despin and solar array mechanisms formed an integral system as the yo-yo cables held the solar array release mechanism in place. The SAMPEX design philosophy was to minimize size and weight through the use of a predominantly single string system. The design challenge was to build a system in a limited space, which was reliable with minimal redundancy. This paper covers the design and development of the SAMPEX yo-yo despin and solar array deployment mechanisms. The problems encountered during development and testing will also be discussed.

Array heterogeneity prevents catastrophic forgetting in infants

PubMed Central

Zosh, Jennifer M.; Feigenson, Lisa

2015-01-01

Working memory is limited in adults and infants. But unlike adults, infants whose working memory capacity is exceeded often fail in a particularly striking way: they do not represent any of the presented objects, rather than simply remembering as many objects as they can and ignoring anything further (Feigenson & Carey 2003, 2005). Here we explored the nature of this “catastrophic forgetting,” asking whether stimuli themselves modulate the way in which infants’ memory fails. We showed 13-month old infants object arrays that either were within or that exceeded working memory capacity—but, unlike previous experiments, presented objects with contrasting features. Although previous studies have repeatedly documented infants’ failure to represent four identical hidden objects, in Experiments 1 and 2 we found that infants who saw four contrasting objects hidden, and then retrieved just two of the four, successfully continued searching for the missing objects. Perceptual contrast between objects sufficed to drive this success; infants succeeded regardless of whether the different objects were contrastively labeled, and regardless of whether the objects were semantically familiar or completely novel. In Experiment 3 we explored the nature of this surprising success, asking whether array heterogeneity actually expanded infants’ working memory capacity or rather prevented catastrophic forgetting. We found that infants successfully continued searching after seeing four contrasting objects hidden and retrieving two of them, but not after retrieving three of them. This suggests that, like adults, infants were able to remember up to, but not beyond, the limits of their working memory capacity when representing heterogeneous arrays. PMID:25543889

Maxillary first molar with three buccal roots evaluated with cone-beam computed tomography: a rare case report.

PubMed

Kottoor, Jojo; Nandini, Suresh; Velmurugan, Natanasabapathy

2012-01-01

This case report describes the nonsurgical endodontic management of a maxillary first molar with the unusual morphology of three separate buccal roots. An accurate assessment of this morphology was made with the help of cone-beam computed tomography (CBCT). This report also describes the varied root morphology associated with maxillary first molars and the role of CBCT as a diagnostic tool for managing these complex cases successfully.

Fluorescence tomography using synchrotron radiation at the NSLS

NASA Astrophysics Data System (ADS)

Boisseau, P.; Grodzins, L.

1987-03-01

Fluorescence tomography utilizing focussed, tunable, monoenergetic X-rays from synchrotron light sources hold the promise of a non-invasive analytic tool for studying trace elements in specimens, particularly biological, at spatial resolutions of the order of micrometers. This note reports an early test at the National Synchrotron Light Source at Brookhaven National Laboratories in which fluorescence tomographic scans were successfully made of trace elements of iron and titanium in NBS standard glass and in a bee.

PET/CT-guided interventions: Indications, advantages, disadvantages and the state of the art.

PubMed

Cazzato, Roberto Luigi; Garnon, Julien; Shaygi, Behnam; Koch, Guillaume; Tsoumakidou, Georgia; Caudrelier, Jean; Addeo, Pietro; Bachellier, Philippe; Namer, Izzie Jacques; Gangi, Afshin

2018-02-01

Positron emission tomography/computed tomography (PET/CT) represents an emerging imaging guidance modality that has been applied to successfully guide percutaneous procedures such as biopsies and tumour ablations. The aim of the present narrative review is to report the indications, advantages and disadvantages of PET/CT-guided procedures in the field of interventional oncology and to briefly describe the experience gained with this new emerging technique while performing biopsies and tumor ablations.

Correction for specimen movement and rotation errors for in-vivo Optical Projection Tomography

PubMed Central

Birk, Udo Jochen; Rieckher, Matthias; Konstantinides, Nikos; Darrell, Alex; Sarasa-Renedo, Ana; Meyer, Heiko; Tavernarakis, Nektarios; Ripoll, Jorge

2010-01-01

The application of optical projection tomography to in-vivo experiments is limited by specimen movement during the acquisition. We present a set of mathematical correction methods applied to the acquired data stacks to correct for movement in both directions of the image plane. These methods have been applied to correct experimental data taken from in-vivo optical projection tomography experiments in Caenorhabditis elegans. Successful reconstructions for both fluorescence and white light (absorption) measurements are shown. Since no difference between movement of the animal and movement of the rotation axis is made, this approach at the same time removes artifacts due to mechanical drifts and errors in the assumed center of rotation. PMID:21258448

Mariner 9 Solar Array Design, Manufacture, and Performance

NASA Technical Reports Server (NTRS)

Sequeira, E. A.

1973-01-01

The mission of Mariner 9, the first spacecraft to orbit another planet, was to make scientific observations of the surface of Mars. Throughout this unique mission, the Mariner 9 solar array successfully supported the power requirements of the spacecraft without experiencing anomalies. Basically, the design of the solar array was similar to those of Mariners 6 and 7; however, Mariner 9 had the additional flight operational requirement to perform in a Mars orbit environment mode. The array special tests provided information on the current-voltage characteristics and array space degradation. Tests indicated that total solar array current degradation was 3.5 percent, which could probably be attributed to the gradual degradation of the cover glass and/or the RTV 602 adhesive employed to cement the cover glass to the solar cell.

Jansky Very Large Array: technology advancing science

NASA Astrophysics Data System (ADS)

Carilli, Christopher

2015-08-01

Over the last decade, the NRAO has completed on time, and on budget, a major reconstruction of the Very Large Array. Building on existing infrastructure to maximize efficiency, the entire VLA electronics system, including correlator, receivers, data transmission, and monitor and control, have been replaced with state of the art systems. This complete rebuild establishes the new Jansky VLA, operating between 75MHz and 50GHz, as the most powerful radio telescope in the world for the coming decade.I will review the technical improvements of the array, including:- Correlator: Increased bandwidth from 100MHz to 8GHz, with thousands of spectral channels.- Receivers: replaced the previous narrow bands with receivers covering the full frequency range from 1 GHz to 50GHz. New systems are also being tested to cover from 50MHz to 400MHz.- Data transmission: 8GHz over optical fiber out to 30km.I will then highlight some of the science enabled by these improvements, including:- Large cosmic volume searches for atomic and molecular gas, from the nearby Universe to the most distant galaxies, plus kpc-scale imaging of the cool gas in distant starburst galaxies.- High resolution studies of star and planet formation.- Innovative interferometric searches for transient phenomena.- The first radio continuum deep fields with sensitivities < 1uJy, with full polarization for Faraday tomography.- Imaging radio-mode feedback in galaxies and clusters, and delineating the complex plasma physical processes involved on scales from a few kpc to hundreds of kpc.I will conclude with a few words about the major challenges facing such a new instrument. These challenges are all on the critical path toward any successful development of future facilities, such as the next generation VLA and SKA:- Big data: data volumes and post-processing are currently major bottlenecks in the turn-over from observation to science publication. NRAO is developing calibration and imaging pipelines to provide science ready data products to the community.- Algorithmic development for ultra-deep, wide band, wide field polarimetric imaging.- Exploring the time domain with interferometers.

Gynecologic electrical impedance tomograph

NASA Astrophysics Data System (ADS)

Korjenevsky, A.; Cherepenin, V.; Trokhanova, O.; Tuykin, T.

2010-04-01

Electrical impedance tomography extends to the new and new areas of the medical diagnostics: lungs, breast, prostate, etc. The feedback from the doctors who use our breast EIT diagnostic system has induced us to develop the 3D electrical impedance imaging device for diagnostics of the cervix of the uterus - gynecologic impedance tomograph (GIT). The device uses the same measuring approach as the breast imaging system: 2D flat array of the electrodes arranged on the probe with handle is placed against the body. Each of the 32 electrodes of the array is connected in turn to the current source while the rest electrodes acquire the potentials on the surface. The current flows through the electrode of the array and returns through the remote electrode placed on the patient's limb. The voltages are measured relative to another remote electrode. The 3D backprojection along equipotential surfaces is used to reconstruct conductivity distribution up to approximately 1 cm in depth. Small number of electrodes enables us to implement real time imaging with a few frames per sec. rate. The device is under initial testing and evaluation of the imaging capabilities and suitability of usage.

The electronics system for the LBNL positron emission mammography (PEM) camera

NASA Astrophysics Data System (ADS)

Moses, W. W.; Young, J. W.; Baker, K.; Jones, W.; Lenox, M.; Ho, M. H.; Weng, M.

2001-06-01

Describes the electronics for a high-performance positron emission mammography (PEM) camera. It is based on the electronics for a human brain positron emission tomography (PET) camera (the Siemens/CTI HRRT), modified to use a detector module that incorporates a photodiode (PD) array. An application-specified integrated circuit (ASIC) services the photodetector (PD) array, amplifying its signal and identifying the crystal of interaction. Another ASIC services the photomultiplier tube (PMT), measuring its output and providing a timing signal. Field-programmable gate arrays (FPGAs) and lookup RAMs are used to apply crystal-by-crystal correction factors and measure the energy deposit and the interaction depth (based on the PD/PMT ratio). Additional FPGAs provide event multiplexing, derandomization, coincidence detection, and real-time rebinning. Embedded PC/104 microprocessors provide communication, real-time control, and configure the system. Extensive use of FPGAs make the overall design extremely flexible, allowing many different functions (or design modifications) to be realized without hardware changes. Incorporation of extensive onboard diagnostics, implemented in the FPGAs, is required by the very high level of integration and density achieved by this system.

Layered-metal-hydroxide nanosheet arrays with controlled nanostructures to assist direct electronic communication at biointerfaces.

PubMed

An, Zhe; Lu, Shan; Zhao, Liwei; He, Jing

2011-10-18

In this work, ordered vertical arrays of layered double hydroxide (LDH) nanosheets have been developed to achieve electron transfer (eT) at biointerfaces in electrochemical devices. It is found that tailoring the gap size of LDH nanosheet arrays could significantly promote the eT rate. This research has successfully extended nanomaterials for efficient modifications of electrode surfaces from nanoparticles, nanowires, nanorods, and nanotubes to nanosheets. © 2011 American Chemical Society

Integration of Organic Electrochemical and Field-Effect Transistors for Ultraflexible, High Temporal Resolution Electrophysiology Arrays.

PubMed

Lee, Wonryung; Kim, Dongmin; Rivnay, Jonathan; Matsuhisa, Naoji; Lonjaret, Thomas; Yokota, Tomoyuki; Yawo, Hiromu; Sekino, Masaki; Malliaras, George G; Someya, Takao

2016-11-01

Integration of organic electrochemical transistors and organic field-effect transistors is successfully realized on a 600 nm thick parylene film toward an electrophysiology array. A single cell of an integrated device and a 2 × 2 electrophysiology array succeed in detecting electromyogram with local stimulation of the motor nerve bundle of a transgenic rat by a laser pulse. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Lightning Mapping With an Array of Fast Antennas

NASA Astrophysics Data System (ADS)

Wu, Ting; Wang, Daohong; Takagi, Nobuyuki

2018-04-01

Fast Antenna Lightning Mapping Array (FALMA), a low-frequency lightning mapping system comprising an array of fast antennas, was developed and established in Gifu, Japan, during the summer of 2017. Location results of two hybrid flashes and a cloud-to-ground flash comprising 11 return strokes (RSs) are described in detail in this paper. Results show that concurrent branches of stepped leaders can be readily resolved, and K changes and dart leaders with speeds up to 2.4 × 107 m/s are also well imaged. These results demonstrate that FALMA can reconstruct three-dimensional structures of lightning flashes with great details. Location accuracy of FALMA is estimated by comparing the located striking points of successive RSs in cloud-to-ground flashes. Results show that distances between successive RSs are mainly below 25 m, indicating exceptionally high location accuracy of FALMA.

Coherent ultra-violet to near-infrared generation in silica ridge waveguides

PubMed Central

Yoon Oh, Dong; Yang, Ki Youl; Fredrick, Connor; Ycas, Gabriel; Diddams, Scott A.; Vahala, Kerry J.

2017-01-01

Short duration, intense pulses of light can experience dramatic spectral broadening when propagating through lengths of optical fibre. This continuum generation process is caused by a combination of nonlinear optical effects including the formation of dispersive waves. Optical analogues of Cherenkov radiation, these waves allow a pulse to radiate power into a distant spectral region. In this work, efficient and coherent dispersive wave generation of visible to ultraviolet light is demonstrated in silica waveguides on a silicon chip. Unlike fibre broadeners, the arrays provide a wide range of emission wavelength choices on a single, compact chip. This new capability is used to simplify offset frequency measurements of a mode-locked frequency comb. The arrays can also enable mode-locked lasers to attain unprecedented tunable spectral reach for spectroscopy, bioimaging, tomography and metrology. PMID:28067233

Ultrasound Imaging Using Diffraction Tomography in a Cylindrical Geometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chambers, D H; Littrup, P

2002-01-24

Tomographic images of tissue phantoms and a sample of breast tissue have been produced from an acoustic synthetic array system for frequencies near 500 kHz. The images for sound speed and attenuation show millimeter resolution and demonstrate the feasibility of obtaining high-resolution tomographic images with frequencies that can deeply penetrate tissue. The image reconstruction method is based on the Born approximation to acoustic scattering and is a simplified version of a method previously used by Andre (Andre, et. al., Int. J. Imaging Systems and Technology, Vol 8, No. 1, 1997) for a circular acoustic array system. The images have comparablemore » resolution to conventional ultrasound images at much higher frequencies (3-5 MHz) but with lower speckle noise. This shows the potential of low frequency, deeply penetrating, ultrasound for high-resolution quantitative imaging.« less

Target detection and localization in shallow water: an experimental demonstration of the acoustic barrier problem at the laboratory scale.

PubMed

Marandet, Christian; Roux, Philippe; Nicolas, Barbara; Mars, Jérôme

2011-01-01

This study demonstrates experimentally at the laboratory scale the detection and localization of a wavelength-sized target in a shallow ultrasonic waveguide between two source-receiver arrays at 3 MHz. In the framework of the acoustic barrier problem, at the 1/1000 scale, the waveguide represents a 1.1-km-long, 52-m-deep ocean acoustic channel in the kilohertz frequency range. The two coplanar arrays record in the time-domain the transfer matrix of the waveguide between each pair of source-receiver transducers. Invoking the reciprocity principle, a time-domain double-beamforming algorithm is simultaneously performed on the source and receiver arrays. This array processing projects the multireverberated acoustic echoes into an equivalent set of eigenrays, which are defined by their launch and arrival angles. Comparison is made between the intensity of each eigenray without and with a target for detection in the waveguide. Localization is performed through tomography inversion of the acoustic impedance of the target, using all of the eigenrays extracted from double beamforming. The use of the diffraction-based sensitivity kernel for each eigenray provides both the localization and the signature of the target. Experimental results are shown in the presence of surface waves, and methodological issues are discussed for detection and localization.

REDUNDANT ARRAY CONFIGURATIONS FOR 21 cm COSMOLOGY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dillon, Joshua S.; Parsons, Aaron R., E-mail: jsdillon@berkeley.edu

Realizing the potential of 21 cm tomography to statistically probe the intergalactic medium before and during the Epoch of Reionization requires large telescopes and precise control of systematics. Next-generation telescopes are now being designed and built to meet these challenges, drawing lessons from first-generation experiments that showed the benefits of densely packed, highly redundant arrays—in which the same mode on the sky is sampled by many antenna pairs—for achieving high sensitivity, precise calibration, and robust foreground mitigation. In this work, we focus on the Hydrogen Epoch of Reionization Array (HERA) as an interferometer with a dense, redundant core designed followingmore » these lessons to be optimized for 21 cm cosmology. We show how modestly supplementing or modifying a compact design like HERA’s can still deliver high sensitivity while enhancing strategies for calibration and foreground mitigation. In particular, we compare the imaging capability of several array configurations, both instantaneously (to address instrumental and ionospheric effects) and with rotation synthesis (for foreground removal). We also examine the effects that configuration has on calibratability using instantaneous redundancy. We find that improved imaging with sub-aperture sampling via “off-grid” antennas and increased angular resolution via far-flung “outrigger” antennas is possible with a redundantly calibratable array configuration.« less

Redundant Array Configurations for 21 cm Cosmology

NASA Astrophysics Data System (ADS)

Dillon, Joshua S.; Parsons, Aaron R.

2016-08-01

Realizing the potential of 21 cm tomography to statistically probe the intergalactic medium before and during the Epoch of Reionization requires large telescopes and precise control of systematics. Next-generation telescopes are now being designed and built to meet these challenges, drawing lessons from first-generation experiments that showed the benefits of densely packed, highly redundant arrays—in which the same mode on the sky is sampled by many antenna pairs—for achieving high sensitivity, precise calibration, and robust foreground mitigation. In this work, we focus on the Hydrogen Epoch of Reionization Array (HERA) as an interferometer with a dense, redundant core designed following these lessons to be optimized for 21 cm cosmology. We show how modestly supplementing or modifying a compact design like HERA’s can still deliver high sensitivity while enhancing strategies for calibration and foreground mitigation. In particular, we compare the imaging capability of several array configurations, both instantaneously (to address instrumental and ionospheric effects) and with rotation synthesis (for foreground removal). We also examine the effects that configuration has on calibratability using instantaneous redundancy. We find that improved imaging with sub-aperture sampling via “off-grid” antennas and increased angular resolution via far-flung “outrigger” antennas is possible with a redundantly calibratable array configuration.

Improved 2-D resistivity imaging of features in covered karst terrain with arrays of implanted electrodes

NASA Astrophysics Data System (ADS)

Kiflu, H. G.; Kruse, S. E.; Harro, D.; Loke, M. H.; Wilkinson, P. B.

2013-12-01

Electrical resistivity tomography is commonly used to identify geologic features associated with sinkhole formation. In covered karst terrain, however, it can be difficult to resolve the depth to top of limestone with this method. This is due to the fact that array lengths, and hence depth of resolution, are often limited by residential or commercial lot dimensions in urban environments. Furthermore, the sediments mantling the limestone are often clay-rich and highly conductive. The resistivity method has limited sensitivity to resistive zones beneath conductive zones. This sensitivity can be improved significantly with electrodes implanted at depth in the cover sediments near the top of limestone. An array of deep electrodes is installed with direct push technology in the karst cover. When combined with a surface array in which each surface electrode is underlain by a deep electrode, the array geometry is similar to a borehole array turned on its side. This method, called the Multi-Electrode Resistivity Implant Technique (MERIT), offers the promise of significantly improved resolution of epikarst and cover collapse development zones in the overlying sediment, the limestone or at the sediment-bedrock interface in heterogeneous karst environments. With a non-traditional array design, the question of optimal array geometries arises. Optimizing array geometries is complicated by the fact that many plausible 4-electrode readings will produce negative apparent resistivity values, even in homogeneous terrain. Negative apparent resistivities cannot be used in inversions based on the logarithm of the apparent resistivity. New algorithms for seeking optimal array geometries have been developed by modifying the 'Compare R' method of Wilkinson and Loke. The optimized arrays show significantly improved resolution over basic arrays adapted from traditional 2D surface geometries. Several MERIT case study surveys have been conducted in covered karst in west-central Florida, with 28-electrode arrays with electrodes 2-5 meters apart, and the deep arrays buried at 4-8 meters depth. Ground penetrating radar surveys, SPT borings and coring data provide selected 'ground truthing'. The case studies show that inclusion of the deep electrode array permits karst features such as undulations at the top of limestone and raveling zones within surficial sediments to be imaged. These features are not accessible from surface arrays with equivalent surface footprints. The method also has better resolution at depth at the ends of the lines, where surface arrays are typically plotted with a trapezoidal truncation due to poor resolution at the lower corners of the profile.

Insights from in-situ X-ray computed tomography during axial impregnation of unidirectional fiber beds

DOE PAGES

Larson, Natalie M.; Zok, Frank W.

2017-12-27

In-situ X-ray computed tomography during axial impregnation of unidirectional fiber beds is used to study coupled effects of fluid velocity, fiber movement and preferred flow channeling on permeability. Here, in order to interpret the experimental measurements, a new computational tool for predicting axial permeability of very large 2D arrays of non-uniformly packed fibers is developed. The results show that, when the impregnation velocity is high, full saturation is attained behind the flow front and the fibers rearrange into a less uniform configuration with higher permeability. In contrast, when the velocity is low, fluid flows preferentially in the narrowest channels betweenmore » fibers, yielding unsaturated permeabilities that are lower than those in the saturated state. Lastly, these insights combined with a new computational tool will enable improved prediction of permeability, ultimately for use in optimization of composite manufacturing via liquid impregnation.« less

4-D photoacoustic tomography.

PubMed

Xiang, Liangzhong; Wang, Bo; Ji, Lijun; Jiang, Huabei

2013-01-01

Photoacoustic tomography (PAT) offers three-dimensional (3D) structural and functional imaging of living biological tissue with label-free, optical absorption contrast. These attributes lend PAT imaging to a wide variety of applications in clinical medicine and preclinical research. Despite advances in live animal imaging with PAT, there is still a need for 3D imaging at centimeter depths in real-time. We report the development of four dimensional (4D) PAT, which integrates time resolutions with 3D spatial resolution, obtained using spherical arrays of ultrasonic detectors. The 4D PAT technique generates motion pictures of imaged tissue, enabling real time tracking of dynamic physiological and pathological processes at hundred micrometer-millisecond resolutions. The 4D PAT technique is used here to image needle-based drug delivery and pharmacokinetics. We also use this technique to monitor 1) fast hemodynamic changes during inter-ictal epileptic seizures and 2) temperature variations during tumor thermal therapy.

In vivo and ex vivo imaging with ultrahigh resolution full-field OCT

NASA Astrophysics Data System (ADS)

Grieve, Kate; Moneron, Gael; Schwartz, Wilfrid; Boccara, Albert C.; Dubois, Arnaud

2005-08-01

Imaging of in vivo and ex vivo biological samples using full-field optical coherence tomography is demonstrated. Three variations on the original full-field optical coherence tomography instrument are presented, and evaluated in terms of performance. The instruments are based on the Linnik interferometer illuminated by a white light source. Images in the en face orientation are obtained in real-time without scanning by using a two-dimensional parallel detector array. An isotropic resolution capability better than 1 μm is achieved thanks to the use of a broad spectrum source and high numerical aperture microscope objectives. Detection sensitivity up to 90 dB is demonstrated. Image acquisition times as short as 10 μs per en face image are possible. A variety of in vivo and ex vivo imaging applications is explored, particularly in the fields of embryology, ophthalmology and botany.

Insights from in-situ X-ray computed tomography during axial impregnation of unidirectional fiber beds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larson, Natalie M.; Zok, Frank W.

In-situ X-ray computed tomography during axial impregnation of unidirectional fiber beds is used to study coupled effects of fluid velocity, fiber movement and preferred flow channeling on permeability. Here, in order to interpret the experimental measurements, a new computational tool for predicting axial permeability of very large 2D arrays of non-uniformly packed fibers is developed. The results show that, when the impregnation velocity is high, full saturation is attained behind the flow front and the fibers rearrange into a less uniform configuration with higher permeability. In contrast, when the velocity is low, fluid flows preferentially in the narrowest channels betweenmore » fibers, yielding unsaturated permeabilities that are lower than those in the saturated state. Lastly, these insights combined with a new computational tool will enable improved prediction of permeability, ultimately for use in optimization of composite manufacturing via liquid impregnation.« less

Slit scan radiographic system for intermediate size rocket motors

NASA Astrophysics Data System (ADS)

Bernardi, Richard T.; Waters, David D.

1992-12-01

The development of slit-scan radiography capability for the NASA Advanced Computed Tomography Inspection System (ACTIS) computed tomography (CT) scanner at MSFC is discussed. This allows for tangential case interface (bondline) inspection at 2 MeV of intermediate-size rocket motors like the Hawk. Motorized mounting fixture hardware was designed, fabricated, installed, and tested on ACTIS. The ACTIS linear array of x-ray detectors was aligned parallel to the tangent line of a horizontal Hawk motor case. A 5 mm thick x-ray fan beam was used. Slit-scan images were produced with continuous rotation of a horizontal Hawk motor. Image features along Hawk motor case interfaces were indicated. A motorized exit cone fixture for ACTIS slit-scan inspection was also provided. The results of this SBIR have shown that slit scanning is an alternative imaging technique for case interface inspection. More data is required to qualify the technique for bondline inspection.

A new approach to depict bone surfaces in finger imaging using photoacoustic tomography

NASA Astrophysics Data System (ADS)

Biswas, S. K.; van Es, P.; Steenbergen, W.; Manohar, S.

2015-03-01

Imaging the vasculature close around the finger joints is of interest in the field of rheumatology. Locally increased vasculature in the synovial membrane of these joints can be a marker for rheumatoid arthritis. In previous work we showed that part of the photoacoustically induced ultrasound from the epidermis reflects on the bone surface within the finger. These reflected signals could be wrongly interpreted as new photoacoustic sources. In this work we show that a conventional ultrasound reconstruction algorithm, that considers the skin as a collection of ultrasound transmitters and the PA tomography probe as the detector array, can be used to delineate bone surfaces of a finger. This can in the future assist in the localization of the joint gaps. This can provide us with a landmark to localize the region of the inflamed synovial membrane. We test the approach on finger mimicking phantoms.

Endodontic Management of Maxillary First Molar With Two Palatal Canals Aided With Cone Beam Computed Tomography: A Case Report.

PubMed

Pamboo, Jaya; Hans, Manoj Kumar; Chander, Subhas; Sharma, Kapil

2017-04-01

The success of endodontic therapy is based on having sufficient endodontic access, correct cleaning and shaping, and adequate root canal obturation. However, endodontic treatment is also dependent on having a sound knowledge of the internal anatomy of human teeth, especially when anatomic variations are present. Reporting these alterations is important for improving the understanding and expertise of endodontists. The aim of this case report is to describe a unique case of maxillary first molar with 2 palatal canals within a single root, as confirmed by cone-beam computed tomography (CBCT) scans. This article also reviews recent case reports of extra palatal root canals in the maxillary first molars and the role of CBCT analysis in successfully diagnosing them.

Washington State Play Fairway Analysis - Passive Monitoring of St. Helens Shear Zone for Tomography and Precision Microseismic Event Detection

DOE Data Explorer

Swyer, Michael (ORCID:0000000309776975); Cladouhos, Trenton; Crosbie, Kayla; Ulberg, Carl (ORCID:000000016198809X)

2017-10-03

Data resources were derived from a passive seismic survey of the northern St. Helens Shear Zone on geothermal leases 12-24 km north of Mount St. Helens for phase 2 of the Geothermal Play-Fairway Analysis of Washington State Prospects. A 20 seismic station array of broadband seismometers was deployed with irregular spacing (1-4 km) over an area of 12 km to image seismogenic features and their damage zones in the shallow crust.

New techniques for positron emission tomography in the study of human neurological disorders for the period June 15, 1987 through December 14, 1987

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuhl, D.E.

1987-09-01

A brief progress report is presented describing the preparation of /sup 11/C-scopolamine, /sup 17/F-fluoromethane and /sup 18/F-tetraalkylammonium fluoride. The application of /sup 11/C-scopolamine to map cholinergic receptors in normal human brain. Additional studies entitled ''The Automated Arterial Blood Sampling Systems for PET'' and ''Investigations of Array Processor Based High-Speed Parameter Estimation for Tracer Kinetic Modeling'' are also described. (DT)

Outlook for Detecting Gravitational Waves with Pulsars

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2016-04-01

Though the recent discovery of GW150914 is a thrilling success in the field of gravitational-wave astronomy, LIGO is only one tool the scientific community is using to hunt for these elusive signals. After 10 years of unsuccessful searching, how likely is it that pulsar-timing-array projects will make their own first detection soon?Frequency ranges for gravitational waves produced by different astrophysical sources. Pulsar timing arrays such as the EPTA and IPTA are used to detect low-frequency gravitational waves generated by the stochastic background and supermassive black hole binaries. [Christopher Moore, Robert Cole and Christopher Berry]Supermassive BackgroundGround-based laser interferometers like LIGO are ideal for probing ripples in space-time caused by the merger of stellar-mass black holes; these mergers cause chirps in the frequency range of tens to thousands of hertz. But how do we pick up the extremely low-frequency, nanohertz background signal caused by the orbits of pairs of supermassive black holes? For that, we need pulsar timing arrays.Pulsar timing arrays are sets of pulsars whose signals are analyzed to look for correlations in the pulse arrival time. As the space-time between us and a pulsar is stretched and then compressed by a passing gravitational wave, the pulsars pulses should arrive a little late and then a little early. Comparing these timing residuals in an array of pulsars could theoretically allow for the detection of the gravitational waves causing them.Globally, there are currently four pulsar timing array projects actively searching for this signal, with a fifth planned for the future. Now a team of scientists led by Stephen Taylor (NASA-JPL/Caltech) has estimated the likelihood that these projects will successfully detect gravitational waves in the future.Probability for SuccessExpected detection probability of the gravitational-wave background as a function of observing time, for five different pulsar timing arrays. Optimistic and conservative assumptions are made for merger rates (blue and red lines, respectively) and environmental conditions (solid and dashed lines, respectively). [Taylor et al. 2016]Taylor and collaborators statistically analyzed the detection probability for each of the projects as a function of their observing time, based on the projects estimated sensitivities and both conservative and optimistic assumptions about merger rates and environmental influences.First the bad news: based on the authors estimates, small arrays which contain only a few pulsars that each have minimal timing noise will not be likely to detect gravitational waves within the next two decades. These arrays are more useful for setting upper limits on the amplitude of the gravitational-wave background.On the other hand, large pulsar timing arrays have far more promising detection probabilities. These include the Parkes Pulsar Timing Array, the European Pulsar Timing Array, andNANOGrav which each targettens ofpulsars,withthe intent toadd more in the future as well as the International Pulsar Timing Array, which combines the efforts of all three of these projects. There is an 80% chance that, within the next decade, these projects will successfully detect the gravitational-wave background created by orbiting supermassive black holes.Based on this study, the outlook for these large arrays remains optimistic even in non-ideal conditions (such as if supermassive-black-hole merger rates are lower than we thought). So, though we may still have to wait a few years, the possibility of probing an otherwise inaccessible range of frequencies continues to make pulsar timing arrays a promising avenue of study for gravitational waves.CitationS. R. Taylor et al 2016 ApJ 819 L6. doi:10.3847/2041-8205/819/1/L6

Split gradient coils for simultaneous PET-MRI

PubMed Central

Poole, Michael; Bowtell, Richard; Green, Dan; Pittard, Simon; Lucas, Alun; Hawkes, Rob; Carpenter, Adrian

2015-01-01

Combining positron emission tomography (PET) and MRI necessarily involves an engineering tradeoff as the equipment needed for the two modalities vies for the space closest to the region where the signals originate. In one recently described scanner configuration for simultaneous positron emission tomography–MRI, the positron emission tomography detection scintillating crystals reside in an 80-mm gap between the 2 halves of a 1-T split-magnet cryostat. A novel set of gradient and shim coils has been specially designed for this split MRI scanner to include an 110-mm gap from which wires are excluded so as not to interfere with positron detection. An inverse boundary element method was necessarily employed to design the three orthogonal, shielded gradient coils and shielded Z0 shim coil. The coils have been constructed and tested in the hybrid positron emission tomography-MRI system and successfully used in simultaneous positron emission tomography-MRI experiments. PMID:19780167

Leak Detection in Spacecraft Using a 64-Element Multiplexed Passive Array to Monitor Structure-Borne Noise

NASA Astrophysics Data System (ADS)

Holland, Stephen D.; Song, Jun-Ho; Chimenti, D. E.; Roberts, Ron

2006-03-01

We demonstrate an array sensor method intended to locate leaks in manned spacecraft using leak-generated, structure-borne ultrasonic noise. We have developed and tested a method for sensing and processing leak noise to reveal the leak location involving the use of a 64-element phased-array. Cross-correlations of ultrasonic noise waveforms from a leak into vacuum have been used with a phased-array analysis to find the direction from the sensor to the leak. This method measures the propagation of guided ultrasonic Lamb waves passing under the PZT array sensor in the spacecraft skin structure. This paper will describe the custom-designed array with integrated electronics, as well as the performance of the array in prototype applications. We show that this method can be used to successfully locate leaks to within a few millimeters on a 0.6-m square aluminum plate.

A finite element-boundary integral method for conformal antenna arrays on a circular cylinder

NASA Technical Reports Server (NTRS)

Kempel, Leo C.; Volakis, John L.; Woo, Alex C.; Yu, C. Long

1992-01-01

Conformal antenna arrays offer many cost and weight advantages over conventional antenna systems. In the past, antenna designers have had to resort to expensive measurements in order to develop a conformal array design. This is due to the lack of rigorous mathematical models for conformal antenna arrays, and as a result the design of conformal arrays is primarily based on planar antenna design concepts. Recently, we have found the finite element-boundary integral method to be very successful in modeling large planar arrays of arbitrary composition in a metallic plane. Herewith we shall extend this formulation for conformal arrays on large metallic cylinders. In this we develop the mathematical formulation. In particular we discuss the finite element equations, the shape elements, and the boundary integral evaluation, and it is shown how this formulation can be applied with minimal computation and memory requirements. The implementation shall be discussed in a later report.

A finite element-boundary integral method for conformal antenna arrays on a circular cylinder

NASA Technical Reports Server (NTRS)

Kempel, Leo C.; Volakis, John L.

1992-01-01

Conformal antenna arrays offer many cost and weight advantages over conventional antenna systems. In the past, antenna designers have had to resort to expensive measurements in order to develop a conformal array design. This was due to the lack of rigorous mathematical models for conformal antenna arrays. As a result, the design of conformal arrays was primarily based on planar antenna design concepts. Recently, we have found the finite element-boundary integral method to be very successful in modeling large planar arrays of arbitrary composition in a metallic plane. We are extending this formulation to conformal arrays on large metallic cylinders. In doing so, we will develop a mathematical formulation. In particular, we discuss the finite element equations, the shape elements, and the boundary integral evaluation. It is shown how this formulation can be applied with minimal computation and memory requirements.

Photovoltaic array space power plus diagnostics experiment

NASA Technical Reports Server (NTRS)

Guidice, Donald A.

1990-01-01

The objective of the Photovoltaic Array Space Power Plus Diagnostics (PASP Plus) experiment is to measure the effects of the interaction of the low- to mid-altitude space environment on the performance of a diverse set of small solar-cell arrays (planar and concentrator, representative of present and future military technologies) under differing conditions of velocity-vector orientation and simulated (by biasing) high-voltage operation. Solar arrays to be tested include Si and GaAs planar arrays and several types of GaAs concentrator arrays. Diagnostics (a Langmuir probe and a pressure gauge) and a transient pulse monitor (to measure radiated and conducted EMI during arcing) will be used to determine the impact of the environment on array operation to help verify various interactions models. Results from a successful PASP Plus flight will furnish answers to important interactions questions and provide inputs for design and test standards for photovoltaic space-power subsystems.

A novel depth-of-interaction block detector for positron emission tomography using a dichotomous orthogonal symmetry decoding concept.

PubMed

Zhang, Yuxuan; Yan, Han; Baghaei, Hossain; Wong, Wai-Hoi

2016-02-21

Conventionally, a dual-end depth-of-interaction (DOI) block detector readout requires two two-dimensional silicon photomultiplier (SiPM) arrays, one on top and one on the bottom, to define the XYZ positions. However, because both the top and bottom SiPM arrays are reading the same pixels, this creates information redundancy. We propose a dichotomous orthogonal symmetric (DOS) dual-end readout block detector design, which removes this redundancy by reducing the number of SiPMs and still achieves XY and DOI (Z) decoding for positron emission tomography (PET) block detector. Reflecting films are used within the block detector to channel photons going to the top of the block to go only in the X direction, and photons going to the bottom are channeled along the Y direction. Despite the unidirectional channeling on each end, the top readout provides both X and Y information using two one-dimensional SiPM arrays instead of a two-dimensional SiPM array; similarly, the bottom readout also provides both X and Y information with just two one-dimensional SiPM arrays. Thus, a total of four one-dimensional SiPM arrays (4  ×  N SiPMs) are used to decode the XYZ positions of the firing pixels instead of two two-dimensional SiPM arrays (2  ×  N  ×  N SiPMs), reducing the number of SiPM arrays per block from 2N(2) to 4 N for PET/MR or PET/CT systems. Moreover, the SiPM arrays on one end can be replaced by two regular photomultiplier tubes (PMTs), so that a block needs only 2 N SiPMs  +  2 half-PMTs; this hybrid-DOS DOI block detector can be used in PET/CT systems. Monte Carlo simulations were carried out to study the performance of our DOS DOI block detector design, including the XY-decoding quality, energy resolution, and DOI resolution. Both BGO and LSO scintillators were studied. We found that 4 mm pixels were well decoded for 5  ×  5 BGO and 9  ×  9 LSO arrays with 4 to 5 mm DOI resolution and 16-20% energy resolution. By adding light-channel decoding, we modified the DOS design to a high-resolution design, which resolved scintillator pixels smaller than the SiPM dimensions. Detector pixels of 2.4 mm were decoded for 8  ×  8 BGO and 15  ×  15 LSO arrays with 5 mm DOI resolution and 20-23% energy resolution. Time performance was also studied for the 8  ×  8 BGO and 15  ×  15 LSO HR-DOS arrays. The timing resolution for the corner and central crystals is 986  ±  122 ps and 1.89  ±  0.17 μs respectively with BGO, 137  ±  42 ps and 458  ±  67 ps respectively with LSO. Monte Carlo simulations with GATE/Geant4 demonstrated the feasibility of our DOS DOI block detector design. In conclusion, our novel design achieved good performance except the time performance while using fewer SiPMs and supporting electronic channels than the current non-DOI PET detectors. This novel design can significantly reduce the cost, heat, and readout complexity of DOI block detectors for PET/MR/CT systems that don't require the time-of-flight capability.

Experiments in ultrasonic flaw detection using a MEMS transducer

NASA Astrophysics Data System (ADS)

Jain, Akash; Greve, David W.; Oppenheim, Irving J.

2003-08-01

In earlier work we developed a MEMS phased array transducer, fabricated in the MUMPs process, and we reported on initial experimental studies in which the device was affixed into contact with solids. We demonstrated the successful detection of signals from a conventional ultrasonic source, and the successful localization of the source in an off-axis geometry using phased array signal processing. We now describe the predicted transmission and coupling characteristics for such devices in contact with solids, demonstrating reasonable agreement with experimental behavior. We then describe the results of flaw detection experiments, as well as results for fluid-coupled detectors.

Upper crustal structure of the North Anatolian Fault Zone from ambient seismic noise Rayleigh and Love wave tomography

NASA Astrophysics Data System (ADS)

Taylor, George; Rost, Sebastian; Houseman, Gregory; Hillers, Gregor

2017-04-01

By utilising short period surface waves present in the noise field, we can construct images of shallow structure in the Earth's upper crust: a region that is usually poorly resolved in earthquake tomography. Here, we use data from a dense seismic array (Dense Array for Northern Anatolia - DANA) deployed across the North Anatolian Fault Zone (NAFZ) in the region of the 1999 magnitude 7.6 Izmit earthquake in western Turkey. The NAFZ is a major strike-slip system that extends ˜1200 km across northern Turkey and continues to pose a high level of seismic hazard, in particular to the mega-city of Istanbul. We obtain maps of group velocity variation using surface wave tomography applied to short period (1- 6 s) Rayleigh and Love waves to construct high-resolution images of the upper 5 km of a 70 km x 35 km region centred on the eastern end of the fault segment that ruptured in the 1999 Izmit earthquake. The average Rayleigh wave group velocities in the region vary between 1.8 km/s at 1.5 s period, to 2.2 km/s at 6 s period. The NAFZ bifurcates into northern and southern strands in this region; both are active but only the northern strand moved in the 1999 event. The signatures of both the northern and southern branches of the NAFZ are clearly associated with strong gradients in surface wave group velocity. To the north of the NAFZ, we observe low Rayleigh wave group velocities ( 1.2 km/s) associated with the unconsolidated sediments of the Adapazari basin, and blocks of weathered terrigenous clastic sediments. To the south of the northern branch of the NAFZ, we detect high velocities ( 2.5 km/s) associated with a shallow crystalline basement, in particular a block of metamorphosed schists and marbles that bound the northern branch of the NAFZ.

Geometry and velocity structure of the northern Costa Rica seismogenic zone from 3D local earthquake tomography

NASA Astrophysics Data System (ADS)

Deshon, H. R.; Schwartz, S. Y.; Newman, A. V.; Dorman, L. M.; Protti, M.; Gonzalez, V.

2003-12-01

We present results of a 3D local earthquake tomography study of the Middle America Trench seismogenic zone in northern Costa Rica. Local earthquake tomography can provide constraints on the updip, downdip, and lateral variability of seismicity and P- and S-wave velocities; these constraints may in turn provide information on compositional and/or mechanical variability along the seismogenic zone. We use arrival time data recorded by the Nicoya Peninsula seismic array, part of the Costa Rica seismogenic zone experiment (CRSEIZE), a collaborative effort undertaken to better understand seismogenic behavior at the Costa Rica subduction zone using data from land and ocean bottom seismic arrays, oceanic fluid flux meters, and GPS receivers. We invert ˜10,000 P-wave and S-wave arrival times from 475 well-recorded local earthquakes (GAP < 180° , >8 P-wave arrivals) to solve for the best-fitting 1D P- and S-wave velocity models, station corrections, and hypocenters using the algorithm VELEST. These 1D velocity models are used as a starting models for 3D simultaneous inversion using the algorithm SIMULPS14. Preliminary P-wave inversions contain a positive velocity anomaly dipping beneath the Nicoya Peninsula, interpreted as the subducting Cocos Plate. Earthquakes occur in a narrow band along the slab-continent interface and are consistent with the results of Newman et al. (2002). The updip limit of seismicity occurs ˜5 km deeper and 5-10 km landward in the northern vs. the southern Nicoya Peninsula, and this shift spatially correlates to the change from Cocos-Nazca to East Pacific Rise derived oceanic plate. P-wave velocities in the upper 5-10 km of the model are consistent with the geology of the Nicoya Peninsula. We will correlate relocated microseismicity to previously noted variability in oceanic plate morphology, heat flow, fluid flow, and thermal structure and compare the resulting P- and S-wave velocity models to wide-angle refraction models and hypothesized mantle wedge compositions.

A front-end wafer-level microsystem packaging technique with micro-cap array

NASA Astrophysics Data System (ADS)

Chiang, Yuh-Min

2002-09-01

The back-end packaging process is the remaining challenge for the micromachining industry to commercialize microsystem technology (MST) devices at low cost. This dissertation presents a novel wafer level protection technique as a final step of the front-end fabrication process for MSTs. It facilitates improved manufacturing throughput and automation in package assembly, wafer level testing of devices, and enhanced device performance. The method involves the use of a wafer-sized micro-cap array, which consists of an assortment of small caps micro-molded onto a material with adjustable shapes and sizes to serve as protective structures against the hostile environments during packaging. The micro-cap array is first constructed by a micromachining process with micro-molding technique, then sealed to the device wafer at wafer level. Epoxy-based wafer-level micro cap array has been successfully fabricated and showed good compatibility with conventional back-end packaging processes. An adhesive transfer technique was demonstrated to seal the micro cap array with a MEMS device wafer. No damage or gross leak was observed while wafer dicing or later during a gross leak test. Applications of the micro cap array are demonstrated on MEMS, microactuators fabricated using CRONOS MUMPS process. Depending on the application needs, the micro-molded cap can be designed and modified to facilitate additional component functions, such as optical, electrical, mechanical, and chemical functions, which are not easily achieved in the device by traditional means. Successful fabrication of a micro cap array comprised with microlenses can provide active functions as well as passive protection. An optical tweezer array could be one possibility for applications of a micro cap with microlenses. The micro cap itself could serve as micro well for DNA or bacteria amplification as well.

Heterogeneous Structure and Seismicity beneath the Tokyo Metropolitan Area

NASA Astrophysics Data System (ADS)

Nakagawa, S.; Kato, A.; Sakai, S.; Nanjo, K.; Panayotopoulos, Y.; Kurashimo, E.; Obara, K.; Kasahara, K.; Aketagawa, T.; Kimura, H.; Hirata, N.

2010-12-01

Beneath the Tokyo metropolitan area, the Philippine Sea Plate (PSP) subducts and causes damaged mega-thrust earthquakes. Sato et al. (2005) revealed the geometry of upper surface of PSP, and Hagiwara et al. (2006) estimated the velocity structure beneath Boso peninsula. However, these results are not sufficient for the assessment of the entire picture of the seismic hazards beneath the Tokyo metropolitan area including those due to an intra-slab M7+ earthquake. So, we launched the Special Project for Earthquake Disaster Mitigation in the Tokyo Metropolitan area (Hirata et al., 2009). Proving the more detailed geometry and physical properties (e.g. velocities, densities, attenuation) and stress field within PSP is very important to attain this issue. The core item of this project is a dense seismic array called Metropolitan Seismic Observation network (MeSO-net) for making observations in the metropolitan area (Sakai and Hirata, 2009; Kasahara et al., 2009). We deployed the 249 seismic stations with a spacing of 5 km. Some parts of stations construct 5 linear arrays at interval of 2 km such as Tsukuba-Fujisawa (TF) array, etc. The TF array runs from northeast to southwest through the center of Tokyo. In this study, we applied the tomography method to image the heterogeneous structure under the Tokyo metropolitan area. We selected events from the Japan Meteorological Agency (JMA) unified earthquake list. All data of MeSO-net were edited into event data by the selected JMA unified earthquake list. We picked the P and S wave arrival times. The total number of stations and events are 421 and 1,256, respectively. Then, we applied the double-difference tomography method (Zhang and Thurber, 2003) to this dataset and estimated the fine-scale velocity structure. The grid nodes locate 10 km interval in parallel with the array, 20 km interval in perpendicular to the array; and on depth direction, 5 km interval to a depth of less than 50 km and 10 km interval at a depth of more. We used 158,930 (P wave) and 149,308 (S wave) absolute arrival times, and 374,072 (P wave) and 354,912 (S wave) differential travel times. The initial velocity structure is the JMA2001 (Ueno et al., 2001), and the Vp/Vs ratio is set to 1.73 for all grid nodes. We imaged the subducting PSP and Pacific Plate clearly. The depth section of P-wave velocity structure along the TF array clearly shows that thin low-velocity layer which overlies high-velocity layer subducts towards northeast. This low-velocity layer corresponds to the oceanic crust of the subducting PSP. The obtained tomograms combined with seismicity and focal mechanisms indicate that the interior of the subducting PSP is characterized by heterogeneous structures, which could exert a profound influence on the genesis of intra-slab earthquakes. Acknowledgement: This study was supported by the Earthquake Research Institute cooperative research program.

Thermal Vacuum/Balance Test Results of Swift BAT with Loop Heat Pipe Thermal System

NASA Technical Reports Server (NTRS)

Choi, Michael K.

2004-01-01

The Swift Burst Alert Telescope (BAT) Detector Array is thermally well coupled to eight constant conductance heat pipes (CCHPs) embedded in the Detector Array Plate PAP), and two loop heat pipes (LHPs) transport heat from the CCHPs to a radiator. The CCHPs have ammonia as the working fluid and the LHPs have propylene as the working fluid. Precision heater controllers, which have adjustable set points in flight, are used to control the LHP compensation chamber and Detector Array xA1 ASIC temperatures. The radiator has AZ-Tek's AZW-LA-II low solar absorptance white paint as the thermal coating, and is located on the anti-sun side of the spacecraft. A thermal balance (T/B) test on the BAT was successfully completed. It validated that the thermal design satisfies the temperature requirements of the BAT in the flight thermal environments. Instrument level and observatory level thermal vacuum (TN) cycling tests of the BAT Detector Array by using the LHP thermal system were successfully completed. This paper presents the results of the T/B test and T N cycling tests.

Large array of 2048 tilting micromirrors for astronomical spectroscopy: optical and cryogenic characterization

NASA Astrophysics Data System (ADS)

Zamkotsian, Frédéric; Canonica, Michael; Lanzoni, Patrick; Noell, Wilfried; Lani, Sebastien

2014-03-01

Multi-object spectroscopy (MOS) is a powerful tool for space and ground-based telescopes for the study of the formation and evolution of galaxies. This technique requires a programmable slit mask for astronomical object selection. We are engaged in a European development of micromirror arrays (MMA) for generating reflective slit masks in future MOS, called MIRA. MMA with 100 × 200 μm2 single-crystal silicon micromirrors were successfully designed, fabricated and tested. Arrays are composed of 2048 micromirrors (32 x 64) with a peak-to-valley deformation less than 10 nm, a tilt angle of 24° for an actuation voltage of 130 V. The micromirrors were actuated successfully before, during and after cryogenic cooling, down to 162K. The micromirror surface deformation was measured at cryo and is below 30 nm peak-to-valley. These performances demonstrate the ability of such MOEMS device to work as objects selector in future generation of MOS instruments both in ground-based and space telescopes. In order to fill large focal planes (mosaicing of several chips), we are currently developing large micromirror arrays integrated with their electronics.

Fabrication of arrayed Si nanowire-based nano-floating gate memory devices on flexible plastics.

PubMed

Yoon, Changjoon; Jeon, Youngin; Yun, Junggwon; Kim, Sangsig

2012-01-01

Arrayed Si nanowire (NW)-based nano-floating gate memory (NFGM) devices with Pt nanoparticles (NPs) embedded in Al2O3 gate layers are successfully constructed on flexible plastics by top-down approaches. Ten arrayed Si NW-based NFGM devices are positioned on the first level. Cross-linked poly-4-vinylphenol (PVP) layers are spin-coated on them as isolation layers between the first and second level, and another ten devices are stacked on the cross-linked PVP isolation layers. The electrical characteristics of the representative Si NW-based NFGM devices on the first and second levels exhibit threshold voltage shifts, indicating the trapping and detrapping of electrons in their NPs nodes. They have an average threshold voltage shift of 2.5 V with good retention times of more than 5 x 10(4) s. Moreover, most of the devices successfully retain their electrical characteristics after about one thousand bending cycles. These well-arrayed and stacked Si NW-based NFGM devices demonstrate the potential of nanowire-based devices for large-scale integration.

Design, implementation and investigation of an image guide-based optical flip-flop array

NASA Technical Reports Server (NTRS)

Griffith, P. C.

1987-01-01

Presented is the design for an image guide-based optical flip-flop array created using a Hughes liquid crystal light valve and a flexible image guide in a feedback loop. This design is used to investigate the application of image guides as a communication mechanism in numerical optical computers. It is shown that image guides can be used successfully in this manner but mismatch match between the input and output fiber arrays is extremely limiting.

Sub-100-nm ordered silicon hole arrays by metal-assisted chemical etching

PubMed Central

2013-01-01

Sub-100-nm silicon nanohole arrays were fabricated by a combination of the site-selective electroless deposition of noble metals through anodic porous alumina and the subsequent metal-assisted chemical etching. Under optimum conditions, the formation of deep straight holes with an ordered periodicity (e.g., 100 nm interval, 40 nm diameter, and high aspect ratio of 50) was successfully achieved. By using the present method, the fabrication of silicon nanohole arrays with 60-nm periodicity was also achieved. PMID:24090268

Flexible crossbar-structured resistive memory arrays on plastic substrates via inorganic-based laser lift-off.

PubMed

Kim, Seungjun; Son, Jung Hwan; Lee, Seung Hyun; You, Byoung Kuk; Park, Kwi-Il; Lee, Hwan Keon; Byun, Myunghwan; Lee, Keon Jae

2014-11-26

Crossbar-structured memory comprising 32 × 32 arrays with one selector-one resistor (1S-1R) components are initially fabricated on a rigid substrate. They are transferred without mechanical damage via an inorganic-based laser lift-off (ILLO) process as a result of laser-material interaction. Addressing tests of the transferred memory arrays are successfully performed to verify mitigation of cross-talk on a plastic substrate. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

GPM Solar Array Gravity Negated Deployment Testing

NASA Technical Reports Server (NTRS)

Penn, Jonathan; Johnson, Chris; Lewis, Jesse; Dear, Trevin; Stewart, Alphonso

2014-01-01

NASA Goddard Space Flight Center (GSFC) successfully developed a g-negation support system for use on the solar arrays of the Global Precipitation Measurement (GPM) Satellite. This system provides full deployment capability at the subsystem and observatory levels. In addition, the system provides capability for deployed configuration first mode frequency verification testing. The system consists of air pads, a support structure, an air supply, and support tables. The g-negation support system was used to support all deployment activities for flight solar array deployment testing.

Method of non-destructively inspecting a curved wall portion

DOEpatents

Fong, James T.

1996-01-01

A method of non-destructively inspecting a curved wall portion of a large and thick walled vessel for a defect by computed tomography is provided. A collimated source of radiation is placed adjacent one side of the wall portion and an array of detectors for the radiation is placed on the other side adjacent the source. The radiation from the source passing through the wall portion is then detected with the detectors over a limited angle, dependent upon the curvature of the wall of the vessel, to obtain a dataset. The source and array are then coordinately moved relative to the wall portion in steps and a further dataset is obtained at each step. The plurality of datasets obtained over the limited angle is then processed to produce a tomogram of the wall portion to determine the presence of a defect therein. In a preferred embodiment, the curved wall portion has a center of curvature so that the source and the array are positioned at each step along a respective arc curved about the center. If desired, the detector array and source can be reoriented relative to a new wall portion and an inspection of the new wall portion can be easily obtained. Further, the source and detector array can be indexed in a direction perpendicular to a plane including the limited angle in a plurality of steps so that by repeating the detecting and moving steps at each index step, a three dimensional image can be created of the wall portion.

Seismic Imaging of a Prospective Geothermal Play, Using a Dense Geophone Array

NASA Astrophysics Data System (ADS)

Trow, A.; Pankow, K. L.; Wannamaker, P. E.; Lin, F. C.; Ward, K. M.

2017-12-01

In the summer of 2016 a dense array of 48 Nodal Seismic geophones was deployed near Beaver, Utah on the eastern flank of the Mineral Mountains. The array aperture was approximately 20 kilometers and recorded continuous seismic data for 30 days. Geophones were centered on a previously known shallow (5km depth) magnetolluric (MT) low-resistivity body. This region of low resistivity was interpreted to possibly contain hydrothermal/geothermal fluids and was targeted for further seismic investigation. The seismic array geometry was designed to optimize seismic event detection for small (magnitude of completeness zero) earthquakes and to facilitate seismic imaging at depths of 5 km and deeper. For the duration of the experiment, one ML 1 earthquake was detected underneath the array with 15 other earthquakes detected to the east and south in the more seismically active Pavant Range. Different passive imaging techniques, including ambient noise and earthquake tomography are being explored in order to produce a seismic velocity image. Understanding the subsurface, specifically the fracture network and fluid content of the bedrock is important for characterization of a geothermal prospect. If it is rich in fluids, it can be assumed that some fracture network is in place to accommodate such fluids. Both fractures and fluid content of the prospect will have an effect on the seismic velocities in the basement structure. These properties can help determine the viability of a geothermal system for power production.

Deployment Methods for an Origami-Inspired Rigid-Foldable Array

NASA Technical Reports Server (NTRS)

Zirbel, Shannon A.; Trease, Brian P.; Magleby, Spencer P.; Howell, Larry L.

2014-01-01

The purpose of this work is to evaluate several deployment methods for an origami-inspired solar array at two size scales: 25-meter array and CubeSat array. The array enables rigid panel deployment and introduces new concepts for actuating CubeSat deployables. The design for the array was inspired by the origami flasher model (Lang, 1997; Shafer, 2001). Figure 1 shows the array prototyped from Garolite and Kapton film at the CubeSat scale. Prior work demonstrated that rigid panels like solar cells could successfully be folded into the final stowed configuration without requiring the panels to flex (Zirbel, Lang, Thomson, & al., 2013). The design of the array is novel and enables efficient use of space. The array can be wrapped around the central bus of the spacecraft in the case of the large array, or can accommodate storage of a small instrument payload in the case of the CubeSat array. The radial symmetry of this array around the spacecraft is ideally suited for spacecraft that need to spin. This work focuses on several actuation methods for a one-time deployment of the array. The array is launched in its stowed configuration and it will be deployed when it is in space. Concepts for both passive and active actuation were considered.

Promising Results from Three NASA SBIR Solar Array Technology Development Programs

NASA Technical Reports Server (NTRS)

Eskenazi, Mike; White, Steve; Spence, Brian; Douglas, Mark; Glick, Mike; Pavlick, Ariel; Murphy, David; O'Neill, Mark; McDanal, A. J.; Piszczor, Michael

2005-01-01

Results from three NASA SBIR solar array technology programs are presented. The programs discussed are: 1) Thin Film Photovoltaic UltraFlex Solar Array; 2) Low Cost/Mass Electrostatically Clean Solar Array (ESCA); and 3) Stretched Lens Array SquareRigger (SLASR). The purpose of the Thin Film UltraFlex (TFUF) Program is to mature and validate the use of advanced flexible thin film photovoltaics blankets as the electrical subsystem element within an UltraFlex solar array structural system. In this program operational prototype flexible array segments, using United Solar amorphous silicon cells, are being manufactured and tested for the flight qualified UltraFlex structure. In addition, large size (e.g. 10 kW GEO) TFUF wing systems are being designed and analyzed. Thermal cycle and electrical test and analysis results from the TFUF program are presented. The purpose of the second program entitled, Low Cost/Mass Electrostatically Clean Solar Array (ESCA) System, is to develop an Electrostatically Clean Solar Array meeting NASA s design requirements and ready this technology for commercialization and use on the NASA MMS and GED missions. The ESCA designs developed use flight proven materials and processes to create a ESCA system that yields low cost, low mass, high reliability, high power density, and is adaptable to any cell type and coverglass thickness. All program objectives, which included developing specifications, creating ESCA concepts, concept analysis and trade studies, producing detailed designs of the most promising ESCA treatments, manufacturing ESCA demonstration panels, and LEO (2,000 cycles) and GEO (1,350 cycles) thermal cycling testing of the down-selected designs were successfully achieved. The purpose of the third program entitled, "High Power Platform for the Stretched Lens Array," is to develop an extremely lightweight, high efficiency, high power, high voltage, and low stowed volume solar array suitable for very high power (multi-kW to MW) applications. These objectives are achieved by combining two cutting edge technologies, the SquareRigger solar array structure and the Stretched Lens Array (SLA). The SLA SquareRigger solar array is termed SLASR. All program objectives, which included developing specifications, creating preliminary designs for a near-term SLASR, detailed structural, mass, power, and sizing analyses, fabrication and power testing of a functional flight-like SLASR solar blanket, were successfully achieved.

A mixed-signal implementation of a polychronous spiking neural network with delay adaptation

PubMed Central

Wang, Runchun M.; Hamilton, Tara J.; Tapson, Jonathan C.; van Schaik, André

2014-01-01

We present a mixed-signal implementation of a re-configurable polychronous spiking neural network capable of storing and recalling spatio-temporal patterns. The proposed neural network contains one neuron array and one axon array. Spike Timing Dependent Delay Plasticity is used to fine-tune delays and add dynamics to the network. In our mixed-signal implementation, the neurons and axons have been implemented as both analog and digital circuits. The system thus consists of one FPGA, containing the digital neuron array and the digital axon array, and one analog IC containing the analog neuron array and the analog axon array. The system can be easily configured to use different combinations of each. We present and discuss the experimental results of all combinations of the analog and digital axon arrays and the analog and digital neuron arrays. The test results show that the proposed neural network is capable of successfully recalling more than 85% of stored patterns using both analog and digital circuits. PMID:24672422

A mixed-signal implementation of a polychronous spiking neural network with delay adaptation.

PubMed

Wang, Runchun M; Hamilton, Tara J; Tapson, Jonathan C; van Schaik, André

2014-01-01

We present a mixed-signal implementation of a re-configurable polychronous spiking neural network capable of storing and recalling spatio-temporal patterns. The proposed neural network contains one neuron array and one axon array. Spike Timing Dependent Delay Plasticity is used to fine-tune delays and add dynamics to the network. In our mixed-signal implementation, the neurons and axons have been implemented as both analog and digital circuits. The system thus consists of one FPGA, containing the digital neuron array and the digital axon array, and one analog IC containing the analog neuron array and the analog axon array. The system can be easily configured to use different combinations of each. We present and discuss the experimental results of all combinations of the analog and digital axon arrays and the analog and digital neuron arrays. The test results show that the proposed neural network is capable of successfully recalling more than 85% of stored patterns using both analog and digital circuits.

IRNSS/NavIC L5 Attitude Determination

PubMed Central

Zaminpardaz, Safoora; Teunissen, Peter J.G.; Nadarajah, Nandakumaran

2017-01-01

The Indian Regional Navigation Satellite System (IRNSS) has recently (May 2016) become fully-operational and has been provided with the operational name of NavIC (Navigation with Indian Constellation). It has been developed by the Indian Space Research Organization (ISRO) with the objective of offering positioning, navigation and timing (PNT) to the users in its service area. This contribution provides for the first time an assessment of the IRNSS L5-signal capability to achieve instantaneous attitude determination on the basis of data collected in Perth, Australia. Our evaluations are conducted for both a linear array of two antennas and a planar array of three antennas. A pre-requisite for precise and fast IRNSS attitude determination is the successful resolution of the double-differenced (DD) integer carrier-phase ambiguities. In this contribution, we will compare the performances of different such methods, amongst which the unconstrained and the multivariate-constrained LAMBDA method for both linear and planar arrays. It is demonstrated that the instantaneous ambiguity success rates increase from 15% to 90% for the linear array and from 5% to close to 100% for the planar array, thus showing that standalone IRNSS can realize 24-h almost instantaneous precise attitude determination with heading and elevation standard deviations of 0.05° and 0.10°, respectively. PMID:28146107

In vivo optical modulation of neural signals using monolithically integrated two-dimensional neural probe arrays

PubMed Central

Son, Yoojin; Jenny Lee, Hyunjoo; Kim, Jeongyeon; Shin, Hyogeun; Choi, Nakwon; Justin Lee, C.; Yoon, Eui-Sung; Yoon, Euisik; Wise, Kensall D.; Geun Kim, Tae; Cho, Il-Joo

2015-01-01

Integration of stimulation modalities (e.g. electrical, optical, and chemical) on a large array of neural probes can enable an investigation of important underlying mechanisms of brain disorders that is not possible through neural recordings alone. Furthermore, it is important to achieve this integration of multiple functionalities in a compact structure to utilize a large number of the mouse models. Here we present a successful optical modulation of in vivo neural signals of a transgenic mouse through our compact 2D MEMS neural array (optrodes). Using a novel fabrication method that embeds a lower cladding layer in a silicon substrate, we achieved a thin silicon 2D optrode array that is capable of delivering light to multiple sites using SU-8 as a waveguide core. Without additional modification to the microelectrodes, the measured impedance of the multiple microelectrodes was below 1 MΩ at 1 kHz. In addition, with a low background noise level (±25 μV), neural spikes from different individual neurons were recorded on each microelectrode. Lastly, we successfully used our optrodes to modulate the neural activity of a transgenic mouse through optical stimulation. These results demonstrate the functionality of the 2D optrode array and its potential as a next-generation tool for optogenetic applications. PMID:26494437

Standing spin-wave mode structure and linewidth in partially disordered hexagonal arrays of perpendicularly magnetized sub-micron Permalloy discs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ross, N., E-mail: rossn2282@gmail.com; Kostylev, M., E-mail: mikhail.kostylev@uwa.edu.au; Stamps, R. L.

2014-09-21

Standing spin wave mode frequencies and linewidths in partially disordered perpendicular magnetized arrays of sub-micron Permalloy discs are measured using broadband ferromagnetic resonance and compared to analytical results from a single, isolated disc. The measured mode structure qualitatively reproduces the structure expected from the theory. Fitted demagnetizing parameters decrease with increasing array disorder. The frequency difference between the first and second radial modes is found to be higher in the measured array systems than predicted by theory for an isolated disc. The relative frequencies between successive spin wave modes are unaffected by reduction of the long-range ordering of discs inmore » the array. An increase in standing spin wave resonance linewidth at low applied magnetic fields is observed and grows more severe with increased array disorder.« less

Thermal cycle testing of Space Station Freedom solar array blanket coupons

NASA Technical Reports Server (NTRS)

Scheiman, David A.; Schieman, David A.

1991-01-01

Lewis Research Center is presently conducting thermal cycle testing of solar array blanket coupons that represent the baseline design for Space Station Freedom. Four coupons were fabricated as part of the Photovoltaic Array Environment Protection (PAEP) Program, NAS 3-25079, at Lockheed Missile and Space Company. The objective of the testing is to demonstrate the durability or operational lifetime of the solar array welded interconnect design within the durability or operational lifetime of the solar array welded interconnect design within a low earth orbit (LEO) thermal cycling environment. Secondary objectives include the observation and identification of potential failure modes and effects that may occur within the solar array blanket coupons as a result of thermal cycling. The objectives, test articles, test chamber, performance evaluation, test requirements, and test results are presented for the successful completion of 60,000 thermal cycles.

Numerical study of read scheme in one-selector one-resistor crossbar array

NASA Astrophysics Data System (ADS)

Kim, Sungho; Kim, Hee-Dong; Choi, Sung-Jin

2015-12-01

A comprehensive numerical circuit analysis of read schemes of a one selector-one resistance change memory (1S1R) crossbar array is carried out. Three schemes-the ground, V/2, and V/3 schemes-are compared with each other in terms of sensing margin and power consumption. Without the aid of a complex analytical approach or SPICE-based simulation, a simple numerical iteration method is developed to simulate entire current flows and node voltages within a crossbar array. Understanding such phenomena is essential in successfully evaluating the electrical specifications of selectors for suppressing intrinsic drawbacks of crossbar arrays, such as sneaky current paths and series line resistance problems. This method provides a quantitative tool for the accurate analysis of crossbar arrays and provides guidelines for developing an optimal read scheme, array configuration, and selector device specifications.

A New Wideband, Fully Steerable, Decametric Array at Clark Lake

NASA Technical Reports Server (NTRS)

Erickson, W. C.; Fisher, J. R.

1974-01-01

A fully steerable, decametric array for radio astronomy is under construction at the Clark Lake Radio Observatory near Borrego Springs, California. This array will be a T of 720 conical spiral antennas (teepee-shaped antennas, hence the array is called the TPT), 3.0 km by 1.8 km capable of operating between 15 and 125 MHz. Both its operating frequency and beam position will be adjustable in less than one millisecond, and the TPT will provide a 49-element picture around the central beam position for extended source observations. Considerable experience was gained in the operation of completed portions of the array, and successful operation of the final array is assured. The results are described of the tests which were conducted with the conical spirals, and the planned electronics and data processing systems are described.

A colorimetric indicator-displacement assay array for selective detection and identification of biological thiols.

PubMed

Qian, Sihua; Lin, Hengwei

2014-03-01

A simple, inexpensive yet highly selective colorimetric indicator-displacement assay array for the simultaneous detection and identification of three important biothiols at micromolar concentrations under physiological conditions and in real samples has been developed in this work. With use of an array composed of metal indicators and metal ions, clear differentiation among cysteine, homocysteine and glutathione was achieved. On the basis of the colour change of the array, quantification of each analyte was accomplished easily, and different biothiols were identified readily using standard chemometric approaches (hierarchical clustering analysis). Moreover, the colorimetric sensor array was not responsive to changes with 19 other natural amino acids, and it showed excellent reproducibility. Importantly, the sensor array developed was successfully applied to the determination and identification of the three biothiols in a real biological sample.

Synthesis and characterization of axial heterojunction inorganic-organic semiconductor nanowire arrays.

PubMed

Chen, Nan; Qian, Xuemin; Lin, Haowei; Liu, Huibiao; Li, Yongjun; Li, Yuliang

2011-11-07

The end-to-end P-N heterojunction nanowire arrays combined organic (poly[1,4-bis(pyrrol-2-yl)benzene], BPB) and inorganic (CdS) molecules have been successfully designed and fabricated. The electrical properties of P-N heterojunctions of organic-inorganic nanowire arrays were investigated. The diode nature and rectifying feature of P-N heterojunction nanowire arrays were observed. The rectification ratio of the diode increased from 29.9 to 129.7 as the illumination intensity increased. The material exhibits a new property, which is an improvement in the integration of the physical and chemical properties of the two independent components.

3D imaging of nanomaterials by discrete tomography.

PubMed

Batenburg, K J; Bals, S; Sijbers, J; Kübel, C; Midgley, P A; Hernandez, J C; Kaiser, U; Encina, E R; Coronado, E A; Van Tendeloo, G

2009-05-01

The field of discrete tomography focuses on the reconstruction of samples that consist of only a few different materials. Ideally, a three-dimensional (3D) reconstruction of such a sample should contain only one grey level for each of the compositions in the sample. By exploiting this property in the reconstruction algorithm, either the quality of the reconstruction can be improved significantly, or the number of required projection images can be reduced. The discrete reconstruction typically contains fewer artifacts and does not have to be segmented, as it already contains one grey level for each composition. Recently, a new algorithm, called discrete algebraic reconstruction technique (DART), has been proposed that can be used effectively on experimental electron tomography datasets. In this paper, we propose discrete tomography as a general reconstruction method for electron tomography in materials science. We describe the basic principles of DART and show that it can be applied successfully to three different types of samples, consisting of embedded ErSi(2) nanocrystals, a carbon nanotube grown from a catalyst particle and a single gold nanoparticle, respectively.

Recent Advances and Field Trial Results Integrating Cosmic Ray Muon Tomography with Other Data Sources for Mineral Exploration

NASA Astrophysics Data System (ADS)

Schouten, D.

2015-12-01

CRM GeoTomography Technologies, Inc. is leading the way in applying muon tomography to discovery and definition of dense ore bodies for mineral exploration and resource estimation. We have successfully imaged volcanogenic massive sulfide (VMS) deposits at mines in North America using our suite of field-proven muon tracking detectors, and are at various stages of development for other applications. Recently we developed in-house inversion software that integrates data from assays, surface and borehole gravity, and underground muon flux measurements. We have found that the differing geophysical data sources provide complementary information and that dramatic improvements in inversion results are attained using various inversion performance metrics related to the excess tonnage of the mineral deposits, as well as their spatial extents and locations. This presentation will outline field tests of muon tomography performed by CRM Geotomography in some real world examples, and will demonstrate the effectiveness of joint muon tomography, assay and gravity inversion techniques in field tests (where data are available) and in simulations.

Rayleigh-wave phase-velocity maps and three-dimensional shear velocity structure of the western US from local non-plane surface wave tomography

USGS Publications Warehouse

Pollitz, F.F.; Snoke, J. Arthur

2010-01-01

We utilize two-and-three-quarter years of vertical-component recordings made by the Transportable Array (TA) component of Earthscope to constrain three-dimensional (3-D) seismic shear wave velocity structure in the upper 200 km of the western United States. Single-taper spectral estimation is used to compile measurements of complex spectral amplitudes from 44 317 seismograms generated by 123 teleseismic events. In the first step employed to determine the Rayleigh-wave phase-velocity structure, we implement a new tomographic method, which is simpler and more robust than scattering-based methods (e.g. multi-plane surface wave tomography). The TA is effectively implemented as a large number of local arrays by defining a horizontal Gaussian smoothing distance that weights observations near a given target point. The complex spectral-amplitude measurements are interpreted with the spherical Helmholtz equation using local observations about a succession of target points, resulting in Rayleigh-wave phase-velocity maps at periods over the range of 18–125 s. The derived maps depend on the form of local fits to the Helmholtz equation, which generally involve the nonplane-wave solutions of Friederich et al. In a second step, the phase-velocity maps are used to derive 3-D shear velocity structure. The 3-D velocity images confirm details witnessed in prior body-wave and surface-wave studies and reveal new structures, including a deep (>100 km deep) high-velocity lineament, of width ∼200 km, stretching from the southern Great Valley to northern Utah that may be a relic of plate subduction or, alternatively, either a remnant of the Mojave Precambrian Province or a mantle downwelling. Mantle seismic velocity is highly correlated with heat flow, Holocene volcanism, elastic plate thickness and seismicity. This suggests that shallow mantle structure provides the heat source for associated magmatism, as well as thinning of the thermal lithosphere, leading to relatively high stress concentration. Our images also confirm the presence of high-velocity mantle at 100 km depth beneath areas of suspected mantle delamination (southern Sierra Nevada; Grande Ronde uplift), low velocity mantle underlying active rift zones, and high velocity mantle associated with the subducting Juan de Fuca plate. Structure established during the Proterozoic appears to exert a lasting influence on subsequent volcanism and tectonism up to the Present.

Enhanced x-ray imaging for a thin film cochlear implant with metal artefacts using phase retrieval tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arhatari, B. D.; ARC Centre of Excellence for Coherent X-ray Science, Melbourne; Harris, A. R.

Phase retrieval tomography has been successfully used to enhance imaging in systems that exhibit poor absorption contrast. However, when highly absorbing regions are present in a sample, so-called metal artefacts can appear in the tomographic reconstruction. We demonstrate that straightforward approaches for metal artefact reconstruction, developed in absorption contrast tomography, can be applied when using phase retrieval. Using a prototype thin film cochlear implant that has high and low absorption components made from iridium (or platinum) and plastic, respectively, we show that segmentation of the various components is possible and hence measurement of the electrode geometry and relative location tomore » other regions of interest can be achieved.« less

The Worldwide Interplanetary Scintillation (IPS) Stations (WIPSS) Network October 2016 Observing Campaign: Initial WIPSS Data Analyses

NASA Astrophysics Data System (ADS)

Bisi, M. M.; Fallows, R. A.; Jackson, B. V.; Tokumaru, M.; Gonzalez-Esparza, A.; Morgan, J.; Chashei, I. V.; Mejia-Ambriz, J.; Tyul'bashev, S. A.; Manoharan, P. K.; De la Luz, V.; Aguilar-Rodriguez, E.; Yu, H. S.; Barnes, D.; Chang, O.; Odstrcil, D.; Fujiki, K.; Shishov, V.

2017-12-01

Interplanetary Scintillation (IPS) allows for the determination of velocity and a proxy for plasma density to be made throughout the corona and inner heliosphere. Where sufficient observations are undertaken, the results can be used as input to the University of California, San Diego (UCSD) three-dimensional (3-D) time-dependent tomography suite to allow for the full 3-D reconstruction of both velocity and density throughout the inner heliosphere. By combining IPS results from multiple observing locations around the planet, we can increase both the temporal and spatial coverage across the whole of the inner heliosphere and hence improve forecast capability. During October 2016, a unique opportunity arose whereby the European-based LOw Frequency ARray (LOFAR) radio telescope was used to make nearly four weeks of continuous observations of IPS as a heliospheric space-weather trial campaign. This was expanded into a global effort to include observations of IPS from the Murchison Widefield Array (MWA) in Western Australia and many more observations from various IPS-dedicated WIPSS Network systems. LOFAR is a next-generation low-frequency radio interferometer capable of observing in the radio frequency range 10-250 MHz, nominally with up to 80 MHz bandwidth at a time. MWA in Western Australia is capable of observing in the 80-300 MHz frequency range nominally using up to 32 MHz of bandwidth. IPS data from LOFAR, ISEE, the MEXican Array Radio Telescope (MEXART), and, where possible, other WIPSS Network systems (such as LPI-BSA and Ooty), will be used in this study and we will present some initial findings for these data sets. We also make a first attempt at the 3-D reconstruction of multiple pertinent WIPSS results in the UCSD tomography. We will also try to highlight some of the potential future tools that make LOFAR a very unique system to be able to test and validate a whole plethora of IPS analysis methods with the same set of IPS data.

Pacific Array of, by and for Global Deep Earth Research

NASA Astrophysics Data System (ADS)

Kawakatsu, H.

2016-12-01

Recent advances in ocean bottom geophysical observations, together with advances in the analysis methodology, have now enabled us to resolve the regional 1-D structure of the entire lithosphere- asthenosphere system (LAS), from the surface to a depth of ˜200km, including seismic anisotropy (azimuthal), with deployments of ˜10-15 BBOBSs & OBEMs each for a year or so (Takeo et al, 2013, 2016; Baba et al., 2013; Lin et al. 2016). Thus the in-situ characterization of the physical properties of the entire oceanic LAS without a priori assumption for the shallow-most structure, the assumption often made for global studies, has become possible. We are now entering a new stage that a large scale array experiment in the ocean (e.g., Pacific Array: http://gachon.eri.u-tokyo.ac.jp/ hitosi/PArray/) has become approachable: having 10-15 BBOBSs as an array unit for a 1-2-year deployment, and repeating such deployments in a leap-frog way or concurrently (an array of arrays) for a decade or so would enable us to cover a large portion of the Pacific basin. Such array observations not only by giving regional constraints on the 1-D structure (including seismic anisotropy), but also by sharing waveform data for global scale waveform tomography (e.g., Fichtner et al. 2010; French et al. 2013; Zhu & Tromp 2013), would drastically increase our knowledge of how plate tectonics works beneath oceanic basins, as well as of the large scale picture of the interior of the Earth. For such an array of arrays to be realized, international collaboration seems essential. If three or four countries collaborate together, it may be achieved within a 10-year time frame that makes this concept attractive. It is also essential that global seismology, geodynamics, and deep earth (GSGD) communities work closely with the ocean science community for Pacific Array to be realized, as they would get most benefit from it. While unit array deployments may have their own scientific goals, it is important that they are planned to fit within a larger international Pacific Array structure. The GSGD community should take a lead in providing such an umbrella, as well as stimulating collaborations between different disciplines .

Effects of reflector and crystal surface on the performance of a depth-encoding PET detector with dual-ended readout

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ren, Silin; Yang, Yongfeng, E-mail: yfyang@ucdavis.edu; Cherry, Simon R.

Purpose: Depth encoding detectors are required to improve the spatial resolution and spatial resolution uniformity of small animal positron emission tomography (PET) scanners, as well as dedicated breast and brain scanners. Depth of interaction (DOI) can be measured by using dual-ended readout of lutetium oxyorthosilicate (LSO) scintillator arrays with position-sensitive avalanche photodiodes. Inter-crystal reflectors and crystal surface treatments play important roles in determining the performance of dual-ended detectors. In this paper, the authors evaluated five LSO arrays made with three different intercrystal reflectors and with either polished or unpolished crystal surfaces. Methods: The crystal size in all arrays was 1.5more » mm, which is typical of the detector size used in small animal and dedicated breast scanners. The LSO arrays were measured with dual-ended readout and were compared in terms of flood histogram, energy resolution, and DOI resolution performance. Results: The four arrays using enhanced specular reflector (ESR) and Toray reflector provided similar quality flood histograms and the array using Crystal Wrap reflector gave the worst flood histogram. The two arrays using ESR reflector provided the best energy resolution and the array using Crystal Wrap reflector yielded the worst energy resolution. All arrays except the polished ESR array provided good DOI resolution ranging from 1.9 mm to 2.9 mm. DOI resolution improved as the gradient in light collection efficiency with depth (GLCED) increased. The geometric mean energies were also calculated for these dual-ended readout detectors as an alternative to the conventional summed total energy. It was shown that the geometric mean energy is advantageous in that it provides more uniform photopeak amplitude at different depths for arrays with high GLCED, and is beneficial in event selection by allowing a fixed energy window independent of depth. A new method of DOI calculation that improved the linearity of DOI ratio vs depth and simplifies the DOI calibration procedure also was developed and tested. Conclusions: The results of these studies provide useful guidance in selecting the proper reflectors and crystal surface treatments when LSO arrays are used for high-resolution PET applications in small animal scanners or dedicated breast and brain scanners.« less

Modularized compact positron emission tomography detector for rapid system development

PubMed Central

Xi, Daoming; Liu, Xiang; Zeng, Chen; Liu, Wei; Li, Yanzhao; Hua, Yuexuan; Mei, Xiongze; Kim, Heejong; Xiao, Peng; Kao, Chien-Min; Xie, Qingguo

2016-01-01

Abstract. We report the development of a modularized compact positron emission tomography (PET) detector that outputs serial streams of digital samples of PET event pulses via an Ethernet interface using the UDP/IP protocol to enable rapid configuration of a PET system by connecting multiple such detectors via a network switch to a computer. Presently, the detector is 76  mm×50  mm×55  mm in extent (excluding I/O connectors) and contains an 18×12 array of 4.2×4.2×20  mm3 one-to-one coupled lutetium-yttrium oxyorthosilicate/silicon photomultiplier pixels. It employs cross-wire and stripline readouts to merge the outputs of the 216 detector pixels to 24 channels. Signals at these channels are sampled using a built-in 24-ch, 4-level field programmable gate arrays-only multivoltage threshold digitizer. In the computer, software programs are implemented to analyze the digital samples to extract event information and to perform energy qualification and coincidence filtering. We have developed two such detectors. We show that all their pixels can be accurately discriminated and measure a crystal-level energy resolution of 14.4% to 19.4% and a detector-level coincidence time resolution of 1.67 ns FWHM. Preliminary imaging results suggests that a PET system based on the detectors can achieve an image resolution of ∼1.6  mm. PMID:28018941

Lithospheric structure of the southeastern margin of the Tibetan Plateau from Rayleigh wave tomography

NASA Astrophysics Data System (ADS)

Fu, Yuanyuan V.; Gao, Yuan; Li, Aibing; Li, Lun; Chen, Anguo

2017-06-01

Lithospheric shear wave velocity beneath the southeastern margin of the Tibetan Plateau is obtained from Rayleigh wave tomography using earthquake data recorded by the temporary ChinArray and permanent China Digital Seismic Array. Fundamental mode Rayleigh wave phase velocities at periods of 20-100 s are determined and used to construct the 3-D shear wave velocity model. Low-velocity anomalies appear along or close to the major faults in the middle crust and become a broad zone in the lower crust, suggesting block extrusion in the shallow crust and diffuse deformation in the lower crust, both of which play important roles in accommodating the collision between the Indian and Eurasian plates. A vertical low-velocity column beneath the Tengchong Volcano is observed, which could be caused by upwelling of warm mantle due to the lithosphere extension in the Thailand rift basin to the south or by fluid-induced partial melting due to the subduction of the Burma slab. The western Yangtze Craton is characterized by low velocity in the crust and uppermost mantle above the fast mantle lithosphere, indicating possible thermal erosion at the western craton edge resulted from the extrusion of the Tibetan Plateau. A low-velocity zone is imaged at the depths of 70-150 km beneath the eastern part of the Yangtze Craton, which could be caused by small-scale mantle convection associated with the subduction of the Burma microplate and/or the opening of the South China Sea.

Lithospheric structure beneath the extinct ridge of South China Sea: Constraints from Rayleigh wave phase velocity tomography using OBS data

NASA Astrophysics Data System (ADS)

Yang, T.; Le, B. M.; passive-Source Seismic Team, S.

2016-12-01

What would happen when a mid-ocean-ridge stops spreading? Global occurrences of such ridges appear to indicate that magmatic activities had continued for million years after ridges were abandoned and often formed seamount chains over ridges. The extinct ridge and the seamount chain at the South China Sea represent one classic example of such ridges. To understand this unique process and the lithospheric and deep mantle structure, we carry out a Rayleigh wave phase velocity tomography using data from a passive-source OBS array experiment in South China Sea from 2012 to 2013. We correct OBS clock errors by using Scholte waves retrieved through cross-correlating hydrophone records of each OBS pair. 60 regional and teleseismic events with high quality Rayleigh waves are selected and their dispersion curves at the OBS array are used to inverse the phase velocities of periods from 15 s to 100 s. The shear wave velocity model derived from phase velocities of all periods shows a strong low-velocity zone situated beneath the seamounts starting at about 30 km depth. The lithosphere thickness of the extinct ridge inferred from this model provide insights on the cooling process and magmatism at this unique oceanic setting. In addition, our model images the tear of the subducting South China Sea plate beneath the Manila trench and Luzon island, which is clearly generated by the subduction of the extinct ridge and overriding seamounts.

Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement

PubMed Central

Gui, Long; Jurgens, Eric M.; Ebner, Jamie L.

2015-01-01

ABSTRACT In order to deliver their genetic material to host cells during infection, enveloped viruses use specialized proteins on their surfaces that bind cellular receptors and induce fusion of the viral and host membranes. In paramyxoviruses, a diverse family of single-stranded RNA (ssRNA) viruses, including several important respiratory pathogens, such as parainfluenza viruses, the attachment and fusion machinery is composed of two separate proteins: a receptor binding protein (hemagglutinin-neuraminidase [HN]) and a fusion (F) protein that interact to effect membrane fusion. Here we used negative-stain and cryo-electron tomography to image the 3-dimensional ultrastructure of human parainfluenza virus 3 (HPIV3) virions in the absence of receptor engagement. We observed that HN exists in at least two organizations. The first were arrays of tetrameric HN that lacked closely associated F proteins: in these purely HN arrays, HN adopted a “heads-down” configuration. In addition, we observed regions of complex surface density that contained HN in an apparently extended “heads-up” form, colocalized with prefusion F trimers. This colocalization with prefusion F prior to receptor engagement supports a model for fusion in which HN in its heads-up state and F may interact prior to receptor engagement without activating F, and that interaction with HN in this configuration is not sufficient to activate F. Only upon receptor engagement by HN’s globular head does HN transmit its activating signal to F. PMID:25691596

Array tomography of physiologically-characterized CNS synapses.

PubMed

Valenzuela, Ricardo A; Micheva, Kristina D; Kiraly, Marianna; Li, Dong; Madison, Daniel V

2016-08-01

The ability to correlate plastic changes in synaptic physiology with changes in synaptic anatomy has been very limited in the central nervous system because of shortcomings in existing methods for recording the activity of specific CNS synapses and then identifying and studying the same individual synapses on an anatomical level. We introduce here a novel approach that combines two existing methods: paired neuron electrophysiological recording and array tomography, allowing for the detailed molecular and anatomical study of synapses with known physiological properties. The complete mapping of a neuronal pair allows determining the exact number of synapses in the pair and their location. We have found that the majority of close appositions between the presynaptic axon and the postsynaptic dendrite in the pair contain synaptic specializations. The average release probability of the synapses between the two neurons in the pair is low, below 0.2, consistent with previous studies of these connections. Other questions, such as receptor distribution within synapses, can be addressed more efficiently by identifying only a subset of synapses using targeted partial reconstructions. In addition, time sensitive events can be captured with fast chemical fixation. Compared to existing methods, the present approach is the only one that can provide detailed molecular and anatomical information of electrophysiologically-characterized individual synapses. This method will allow for addressing specific questions about the properties of identified CNS synapses, even when they are buried within a cloud of millions of other brain circuit elements. Copyright © 2016. Published by Elsevier B.V.

Micromachined silicon acoustic delay line with improved structural stability and acoustic directivity for real-time photoacoustic tomography

NASA Astrophysics Data System (ADS)

Cho, Young; Kumar, Akhil; Xu, Song; Zou, Jun

2017-03-01

Recent studies have shown that micromachined silicon acoustic delay lines can provide a promising solution to achieve real-time photoacoustic tomography without the need for complex transducer arrays and data acquisition electronics. However, as its length increases to provide longer delay time, the delay line becomes more vulnerable to structural instability due to reduced mechanical stiffness. In addition, the small cross-section area of the delay line results in a large acoustic acceptance angle and therefore poor directivity. To address these two issues, this paper reports the design, fabrication, and testing of a new silicon acoustic delay line enhanced with 3D printed polymer micro linker structures. First, mechanical deformation of the silicon acoustic delay line (with and without linker structures) under gravity was simulated by using finite element method. Second, the acoustic crosstalk and acoustic attenuation caused by the polymer micro linker structures were evaluated with both numerical simulation and ultrasound transmission testing. The result shows that the use of the polymer micro linker structures significantly improves the structural stability of the silicon acoustic delay lines without creating additional acoustic attenuation and crosstalk. In addition, a new tapered design for the input terminal of the delay line was also investigate to improve its acoustic directivity by reducing the acoustic acceptance angle. These two improvements are expected to provide an effective solution to eliminate current limitations on the achievable acoustic delay time and out-of-plane imaging resolution of micromachined silicon acoustic delay line arrays.

Electrical Capacitance Volume Tomography with High-Contrast Dielectrics

NASA Technical Reports Server (NTRS)

Nurge, Mark

2010-01-01

The Electrical Capacitance Volume Tomography (ECVT) system has been designed to complement the tools created to sense the presence of water in nonconductive spacecraft materials, by helping to not only find the approximate location of moisture but also its quantity and depth. The ECVT system has been created for use with a new image reconstruction algorithm capable of imaging high-contrast dielectric distributions. Rather than relying solely on mutual capacitance readings as is done in traditional electrical capacitance tomography applications, this method reconstructs high-resolution images using only the self-capacitance measurements. The image reconstruction method assumes that the material under inspection consists of a binary dielectric distribution, with either a high relative dielectric value representing the water or a low dielectric value for the background material. By constraining the unknown dielectric material to one of two values, the inverse math problem that must be solved to generate the image is no longer ill-determined. The image resolution becomes limited only by the accuracy and resolution of the measurement circuitry. Images were reconstructed using this method with both synthetic and real data acquired using an aluminum structure inserted at different positions within the sensing region. The cuboid geometry of the system has two parallel planes of 16 conductors arranged in a 4 4 pattern. The electrode geometry consists of parallel planes of copper conductors, connected through custom-built switch electronics, to a commercially available capacitance to digital converter. The figure shows two 4 4 arrays of electrodes milled from square sections of copper-clad circuit-board material and mounted on two pieces of glass-filled plastic backing, which were cut to approximately square shapes, 10 cm on a side. Each electrode is placed on 2.0-cm centers. The parallel arrays were mounted with the electrode arrays approximately 3 cm apart. The open ends were surrounded by a metal guard to reduce the sensitivity of the electrodes to outside interference and to help maintain the spacing between the arrays. Other uses for this innovation potentially include quantifying the amount of commodity remaining in the fuel and oxidizer tanks while on-orbit without having to fire spacecraft engines. Another orbit application is moisture sensing in plant-growth experiments because microgravity causes moisture in soil to distribute itself in unusual ways. At the moment, the hardware and image reconstruction technique may only be of interest to people involved in nondestructive evaluation. The reconstructed image takes almost a full week to reproduce with existing computer power. However, because computer power and speeds follows Moore s Law, execution times are likely to become acceptable within the next five to eight years. The code was written in Mathematica for dedicated use with the ECVT system. In its present form, it is not suitable to be used directly as a consumer product. However, the code could be likely improved by rewriting it in a compiled language such as C or Fortran.

In vivo ultrasound imaging of the bone cortex

NASA Astrophysics Data System (ADS)

Renaud, Guillaume; Kruizinga, Pieter; Cassereau, Didier; Laugier, Pascal

2018-06-01

Current clinical ultrasound scanners cannot be used to image the interior morphology of bones because these scanners fail to address the complicated physics involved for exact image reconstruction. Here, we show that if the physics is properly addressed, bone cortex can be imaged using a conventional transducer array and a programmable ultrasound scanner. We provide in vivo proof for this technique by scanning the radius and tibia of two healthy volunteers and comparing the thickness of the radius bone with high-resolution peripheral x-ray computed tomography. Our method assumes a medium that is composed of different homogeneous layers with unique elastic anisotropy and ultrasonic wave-speed values. The applicable values of these layers are found by optimizing image sharpness and intensity over a range of relevant values. In the algorithm of image reconstruction we take wave refraction between the layers into account using a ray-tracing technique. The estimated values of the ultrasonic wave-speed and anisotropy in cortical bone are in agreement with ex vivo studies reported in the literature. These parameters are of interest since they were proposed as biomarkers for cortical bone quality. In this paper we discuss the physics involved with ultrasound imaging of bone and provide an algorithm to successfully image the first segment of cortical bone.

Analysis and experimental demonstration of conformal adaptive phase-locked fiber array for laser communications and beam projection applications

NASA Astrophysics Data System (ADS)

Liu, Ling

The primary goal of this research is the analysis, development, and experimental demonstration of an adaptive phase-locked fiber array system for free-space optical communications and laser beam projection applications. To our knowledge, the developed adaptive phase-locked system composed of three fiber collimators (subapertures) with tip-tilt wavefront phase control at each subaperture represents the first reported fiber array system that implements both phase-locking control and adaptive wavefront tip-tilt control capabilities. This research has also resulted in the following innovations: (a) The first experimental demonstration of a phase-locked fiber array with tip-tilt wave-front aberration compensation at each fiber collimator; (b) Development and demonstration of the fastest currently reported stochastic parallel gradient descent (SPGD) system capable of operation at 180,000 iterations per second; (c) The first experimental demonstration of a laser communication link based on a phase-locked fiber array; (d) The first successful experimental demonstration of turbulence and jitter-induced phase distortion compensation in a phase-locked fiber array optical system; (e) The first demonstration of laser beam projection onto an extended target with a randomly rough surface using a conformal adaptive fiber array system. Fiber array optical systems, the subject of this study, can overcome some of the draw-backs of conventional monolithic large-aperture transmitter/receiver optical systems that are usually heavy, bulky, and expensive. The primary experimental challenges in the development of the adaptive phased-locked fiber-array included precise (<5 microrad) alignment of the fiber collimators and development of fast (100kHz-class) phase-locking and wavefront tip-tilt control systems. The precise alignment of the fiber collimator array is achieved through a specially developed initial coarse alignment tool based on high precision piezoelectric picomotors and a dynamic fine alignment mechanism implemented with specially designed and manufactured piezoelectric fiber positioners. Phase-locking of the fiber collimators is performed by controlling the phases of the output beams (beamlets) using integrated polarization-maintaining (PM) fiber-coupled LiNbO3 phase shifters. The developed phase-locking controllers are based on either the SPGD algorithm or the multi-dithering technique. Subaperture wavefront phase tip-tilt control is realized using piezoelectric fiber positioners that are controlled using a computer-based SPGD controller. Both coherent (phase-locked) and incoherent beam combining in the fiber array system are analyzed theoretically and experimentally. Two special fiber-based beam-combining testbeds have been built to demonstrate the technical feasibility of phase-locking compensation prior to free-space operation. In addition, the reciprocity of counter-propagating beams in a phase-locked fiber array system has been investigated. Coherent beam combining in a phase-locking system with wavefront phase tip-tilt compensation at each subaperture is successfully demonstrated when laboratory-simulated turbulence and wavefront jitters are present in the propagation path of the beamlets. In addition, coherent beam combining with a non-cooperative extended target in the control loop is successfully demonstrated.

Image Registration of Cone-Beam Computer Tomography and Preprocedural Computer Tomography Aids in Localization of Adrenal Veins and Decreasing Radiation Dose in Adrenal Vein Sampling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Busser, Wendy M. H., E-mail: wendy.busser@radboudumc.nl; Arntz, Mark J.; Jenniskens, Sjoerd F. M.

2015-08-15

PurposeWe assessed whether image registration of cone-beam computed tomography (CT) (CBCT) and contrast-enhanced CT (CE-CT) images indicating the locations of the adrenal veins can aid in increasing the success rate of first-attempts adrenal vein sampling (AVS) and therefore decreasing patient radiation dose.Materials and Methods CBCT scans were acquired in the interventional suite (Philips Allura Xper FD20) and rigidly registered to the vertebra in previously acquired CE-CT. Adrenal vein locations were marked on the CT image and superimposed with live fluoroscopy and digital-subtraction angiography (DSA) to guide the AVS. Seventeen first attempts at AVS were performed with image registration and retrospectivelymore » compared with 15 first attempts without image registration performed earlier by the same 2 interventional radiologists. First-attempt AVS was considered successful when both adrenal vein samples showed representative cortisol levels. Sampling time, dose-area product (DAP), number of DSA runs, fluoroscopy time, and skin dose were recorded.ResultsWithout image registration, the first attempt at sampling was successful in 8 of 15 procedures indicating a success rate of 53.3 %. This increased to 76.5 % (13 of 17) by adding CBCT and CE-CT image registration to AVS procedures (p = 0.266). DAP values (p = 0.001) and DSA runs (p = 0.026) decreased significantly by adding image registration guidance. Sampling and fluoroscopy times and skin dose showed no significant changes.ConclusionGuidance based on registration of CBCT and previously acquired diagnostic CE-CT can aid in enhancing localization of the adrenal veins thereby increasing the success rate of first-attempt AVS with a significant decrease in the number of used DSA runs and, consequently, radiation dose required.« less

The Influence of Surgical Stabilization on Glenohumeral Abduction Using 3-Dimensional Computed Tomography in Patients With Shoulder Instability.

PubMed

Bakshi, Neil K; Jameel, Omar F; Merrill, Zachary F; Debski, Richard E; Sekiya, Jon K

2016-08-01

This study compared the amount of glenohumeral abduction during arm abduction in the affected and unaffected shoulders of 3 groups of patients with shoulder instability: failed surgical stabilization, successful surgical stabilization, and unstable shoulder with no prior surgical intervention. All patients underwent bilateral shoulder computed tomography scans in 3 positions: 0° of abduction and 0° of external rotation (0-0 position), 30° of abduction and 30° of external rotation (30-30 position), and arms maximally abducted (overhead position). Three-dimensional computed tomography reconstruction was performed for both shoulders in all 3 positions. A specialized coordinate system marked specific points and directions on the humerus and glenoid of each model. These coordinates were used to calculate the glenohumeral abduction for the normal and affected sides in the 0-0, 30-30, and overhead positions. Thirty-nine patients with shoulder instability were included, of whom 14 had failed surgical repairs, 10 had successful surgical repairs, and 15 had unstable shoulders with no prior surgical intervention. In the overhead position, patients with failed surgical intervention had significantly less glenohumeral abduction in the failed shoulder (95.6° ± 12.7°) compared with the normal shoulder (101.5° ± 12.4°, P = .02). Patients with successfully stabilized shoulders had significantly less glenohumeral abduction in the successfully stabilized shoulder (93.6° ± 10.8°) compared with the normal shoulder (102.1° ± 12.5°, P = .03). Unstable shoulders with no prior surgical intervention (102.1° ± 10.3°) did not differ when compared with the normal shoulders (101.9° ± 10.9°, P = .95). Surgical intervention, regardless of its success, limits the amount of abduction at the glenohumeral joint. Level III, retrospective comparative study. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Rigid and flexible organic electrochemical transistor arrays for monitoring action potentials from electrogenic cells.

PubMed

Yao, Chunlei; Li, Qianqian; Guo, Jing; Yan, Feng; Hsing, I-Ming

2015-03-11

Rigid and flexible organic electrochemical transistor arrays are successfully implemented for monitoring cardiac action potentials. Excellent signal to noise ratios are achieved with values routinely larger than 4. These devices are promising to be used in both conventional and emerging areas. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Radar Resource Management in a Dense Target Environment

DTIC Science & Technology

2014-03-01

problem faced by networked MFRs . While relaxing our assumptions concerning information gain presents numerous challenges worth exploring, future research...linear programming MFR multifunction phased array radar MILP mixed integer linear programming NATO North Atlantic Treaty Organization PDF probability...1: INTRODUCTION Multifunction phased array radars ( MFRs ) are capable of performing various tasks in rapid succession. The performance of target search

Skylab experiment performance evaluation manual. Appendix S: Experiment T027 contamination measurement sample array (MSFC)

NASA Technical Reports Server (NTRS)

Tonetti, B. B.

1973-01-01

Analyses for Experiment T027, Contamination Measurement Sample Array (MSFC), to be used for evaluating the performance of the Skylab corrollary experiments under preflight, inflight, and post-flight conditions are presented. Experiment contingency plan workaround procedure and malfunction analyses are presented in order to assist in making the experiment operationally successful.

Endodontic management of supernumerary tooth fused with maxillary first molar by using cone-beam computed tomography.

PubMed

Song, Chang-Kyu; Chang, Hoon-Sang; Min, Kyung-San

2010-11-01

Fusion is a rare occurrence, and its definitive diagnosis is of prime importance for successful root canal treatment. This case report discusses the endodontic management of a supernumerary tooth fused with a right maxillary first molar by using cone-beam computed tomography (CBCT). Nonsurgical endodontic retreatment was performed on the supernumerary tooth. A communication between the maxillary first molar and the supernumerary tooth was repaired by using flowable resin. After 1 year of follow-up, there were no clinical symptoms, and the maxillary first molar remained vital. Recall radiographs and CBCT showed satisfactory healing of the periapical pathosis. Proper diagnosis and treatment planning for endodontic management of fused teeth by using CBCT can ensure predictable and successful results. Copyright © 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Sonography of the chest using linear-array versus sector transducers: Correlation with auscultation, chest radiography, and computed tomography.

PubMed

Tasci, Ozlem; Hatipoglu, Osman Nuri; Cagli, Bekir; Ermis, Veli

2016-07-08

The primary purpose of our study was to compare the efficacies of two sonographic (US) probes, a high-frequency linear-array probe and a lower-frequency phased-array sector probe in the diagnosis of basic thoracic pathologies. The secondary purpose was to compare the diagnostic performance of thoracic US with auscultation and chest radiography (CXR) using thoracic CT as a gold standard. In total, 55 consecutive patients scheduled for thoracic CT were enrolled in this prospective study. Four pathologic entities were evaluated: pneumothorax, pleural effusion, consolidation, and interstitial syndrome. A portable US scanner was used with a 5-10-MHz linear-array probe and a 1-5-MHz phased-array sector probe. The first probe used was chosen randomly. US, CXR, and auscultation results were compared with the CT results. The linear-array probe had the highest performance in the identification of pneumothorax (83% sensitivity, 100% specificity, and 99% diagnostic accuracy) and pleural effusion (100% sensitivity, 97% specificity, and 98% diagnostic accuracy); the sector probe had the highest performance in the identification of consolidation (89% sensitivity, 100% specificity, and 95% diagnostic accuracy) and interstitial syndrome (94% sensitivity, 93% specificity, and 94% diagnostic accuracy). For all pathologies, the performance of US was superior to those of CXR and auscultation. The linear probe is superior to the sector probe for identifying pleural pathologies, whereas the sector probe is superior to the linear probe for identifying parenchymal pathologies. Thoracic US has better diagnostic performance than CXR and auscultation for the diagnosis of common pathologic conditions of the chest. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44:383-389, 2016. © 2016 Wiley Periodicals, Inc.

Eye-movements intervening between two successive sounds disrupt comparisons of auditory location

PubMed Central

Pavani, Francesco; Husain, Masud; Driver, Jon

2008-01-01

Summary Many studies have investigated how saccades may affect the internal representation of visual locations across eye-movements. Here we studied instead whether eye-movements can affect auditory spatial cognition. In two experiments, participants judged the relative azimuth (same/different) of two successive sounds presented from a horizontal array of loudspeakers, separated by a 2.5 secs delay. Eye-position was either held constant throughout the trial (being directed in a fixed manner to the far left or right of the loudspeaker array), or had to be shifted to the opposite side of the array during the retention delay between the two sounds, after the first sound but before the second. Loudspeakers were either visible (Experiment1) or occluded from sight (Experiment 2). In both cases, shifting eye-position during the silent delay-period affected auditory performance in the successive auditory comparison task, even though the auditory inputs to be judged were equivalent. Sensitivity (d′) for the auditory discrimination was disrupted, specifically when the second sound shifted in the opposite direction to the intervening eye-movement with respect to the first sound. These results indicate that eye-movements affect internal representation of auditory location. PMID:18566808

Eye-movements intervening between two successive sounds disrupt comparisons of auditory location.

PubMed

Pavani, Francesco; Husain, Masud; Driver, Jon

2008-08-01

Many studies have investigated how saccades may affect the internal representation of visual locations across eye-movements. Here, we studied, instead, whether eye-movements can affect auditory spatial cognition. In two experiments, participants judged the relative azimuth (same/different) of two successive sounds presented from a horizontal array of loudspeakers, separated by a 2.5-s delay. Eye-position was either held constant throughout the trial (being directed in a fixed manner to the far left or right of the loudspeaker array) or had to be shifted to the opposite side of the array during the retention delay between the two sounds, after the first sound but before the second. Loudspeakers were either visible (Experiment 1) or occluded from sight (Experiment 2). In both cases, shifting eye-position during the silent delay-period affected auditory performance in thn the successive auditory comparison task, even though the auditory inputs to be judged were equivalent. Sensitivity (d') for the auditory discrimination was disrupted, specifically when the second sound shifted in the opposite direction to the intervening eye-movement with respect to the first sound. These results indicate that eye-movements affect internal representation of auditory location.

Bio-Inspired Bright Structurally Colored Colloidal Amorphous Array Enhanced by Controlling Thickness and Black Background.

PubMed

Iwata, Masanori; Teshima, Midori; Seki, Takahiro; Yoshioka, Shinya; Takeoka, Yukikazu

2017-07-01

Inspired by Steller's jay, which displays angle-independent structural colors, angle-independent structurally colored materials are created, which are composed of amorphous arrays of submicrometer-sized fine spherical silica colloidal particles. When the colloidal amorphous arrays are thick, they do not appear colorful but almost white. However, the saturation of the structural color can be increased by (i) appropriately controlling the thickness of the array and (ii) placing the black background substrate. This is similar in the case of the blue feather of Steller's jay. Based on the knowledge gained through the biomimicry of structural colored materials, colloidal amorphous arrays on the surface of a black particle as the core particle are also prepared as colorful photonic pigments. Moreover, a structural color on-off system is successfully built by controlling the background brightness of the colloidal amorphous arrays. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Magnetic characteristics of CoPd and FePd antidot arrays on nanoperforated Al2O3 templates

NASA Astrophysics Data System (ADS)

Maximenko, A.; Fedotova, J.; Marszałek, M.; Zarzycki, A.; Zabila, Y.

2016-02-01

Hard magnetic antidot arrays show promising results in context of designing of percolated perpendicular media. In this work the technology of magnetic FePd and CoPd antidot arrays fabrication is presented and correlation between surface morphology, structure and magnetic properties is discussed. CoPd and FePd antidot arrays were fabricated by deposition of Co/Pd and Fe/Pd multilayers (MLs) on porous anodic aluminum oxide templates with bowl-shape cell structure with inclined intercellular regions. FePd ordered L10 structure was obtained by successive vacuum annealing at elevated temperatures (530 °C) and confirmed by XRD analysis. Systematic analysis of magnetization curves evidenced perpendicular magnetic anisotropy of CoPd antidot arrays, while FePd antidot arrays revealed isotropic magnetic anisotropy with increased out-of-plane magnetic contribution. MFM images of antidots showed more complicated contrast, with alternating magnetic dots oriented parallel and antiparallel to tip magnetization moment.

On the possibility of using multi-element phased arrays for shock-wave action on deep brain structures

NASA Astrophysics Data System (ADS)

Rosnitskiy, P. B.; Gavrilov, L. R.; Yuldashev, P. V.; Sapozhnikov, O. A.; Khokhlova, V. A.

2017-09-01

A noninvasive ultrasound surgery method that relies on using multi-element focused phased arrays is being successfully used to destroy tumors and perform neurosurgical operations in deep structures of the human brain. However, several drawbacks that limit the possibilities of the existing systems in their clinical use have been revealed: a large size of the hemispherical array, impossibility of its mechanical movement relative to the patient's head, limited volume of dynamic focusing around the center of curvature of the array, and side effect of overheating skull. Here we evaluate the possibility of using arrays of smaller size and aperture angles to achieve shock-wave formation at the focus for thermal and mechanical ablation (histotripsy) of brain tissue taking into account current intensity limitations at the array elements. The proposed approach has potential advantages to mitigate the existing limitations and expand the possibilities of transcranial ultrasound surgery.

Gold patterned biochips for on-chip immuno-MALDI-TOF MS: SPR imaging coupled multi-protein MS analysis.

PubMed

Kim, Young Eun; Yi, So Yeon; Lee, Chang-Soo; Jung, Yongwon; Chung, Bong Hyun

2012-01-21

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis of immuno-captured target protein efficiently complements conventional immunoassays by offering rich molecular information such as protein isoforms or modifications. Direct immobilization of antibodies on MALDI solid support enables both target enrichment and MS analysis on the same plate, allowing simplified and potentially multiplexing protein MS analysis. Reliable on-chip immuno-MALDI-TOF MS for multiple biomarkers requires successful adaptation of antibody array biochips, which also must accommodate consistent reaction conditions on antibody arrays during immuno-capture and MS analysis. Here we developed a facile fabrication process of versatile antibody array biochips for reliable on-chip MALDI-TOF-MS analysis of multiple immuno-captured proteins. Hydrophilic gold arrays surrounded by super-hydrophobic surfaces were formed on a gold patterned biochip via spontaneous chemical or protein layer deposition. From antibody immobilization to MALDI matrix treatment, this hydrophilic/phobic pattern allowed highly consistent surface reactions on each gold spot. Various antibodies were immobilized on these gold spots both by covalent coupling or protein G binding. Four different protein markers were successfully analyzed on the present immuno-MALDI biochip from complex protein mixtures including serum samples. Tryptic digests of captured PSA protein were also effectively detected by on-chip MALDI-TOF-MS. Moreover, the present MALDI biochip can be directly applied to the SPR imaging system, by which antibody and subsequent antigen immobilization were successfully monitored.

Development of PET/MRI with insertable PET for simultaneous PET and MR imaging of human brain.

PubMed

Jung, Jin Ho; Choi, Yong; Jung, Jiwoong; Kim, Sangsu; Lim, Hyun Keong; Im, Ki Chun; Oh, Chang Hyun; Park, Hyun-wook; Kim, Kyung Min; Kim, Jong Guk

2015-05-01

The purpose of this study was to develop a dual-modality positron emission tomography (PET)/magnetic resonance imaging (MRI) with insertable PET for simultaneous PET and MR imaging of the human brain. The PET detector block was composed of a 4 × 4 matrix of detector modules, each consisting of a 4 × 4 array LYSO coupled to a 4 × 4 Geiger-mode avalanche photodiode (GAPD) array. The PET insert consisted of 18 detector blocks, circularly mounted on a custom-made plastic base to form a ring with an inner diameter of 390 mm and axial length of 60 mm. The PET gantry was shielded with gold-plated conductive fabric tapes with a thickness of 0.1 mm. The charge signals of PET detector transferred via 4 m long flat cables were fed into the position decoder circuit. The flat cables were shielded with a mesh-type aluminum sheet with a thickness of 0.24 mm. The position decoder circuit and field programmable gate array-embedded DAQ modules were enclosed in an aluminum box with a thickness of 10 mm and located at the rear of the MR bore inside the MRI room. A 3-T human MRI system with a Larmor frequency of 123.7 MHz and inner bore diameter of 60 cm was used as the PET/MRI hybrid system. A custom-made radio frequency (RF) coil with an inner diameter of 25 cm was fabricated. The PET was positioned between gradient and the RF coils. PET performance was measured outside and inside the MRI scanner using echo planar imaging, spin echo, turbo spin echo, and gradient echo sequences. MRI performance was also evaluated with and without the PET insert. The stability of the newly developed PET insert was evaluated and simultaneous PET and MR images of a brain phantom were acquired. No significant degradation of the PET performance caused by MR was observed when the PET was operated using various MR imaging sequences. The signal-to-noise ratio of MR images was slightly degraded due to the PET insert installed inside the MR bore while the homogeneity was maintained. The change of gain of the 256 GAPD/scintillator elements of a detector block was <3% for 60 min, and simultaneous PET and MR images of a brain phantom were successfully acquired. Experimental results indicate that a compact and lightweight PET insert for hybrid PET/MRI can be developed using GAPD arrays and charge signal transmission method proposed in this study without significant interference.

Photovoltaic solar array technology required for three wide scale generating systems for terrestrial applications: rooftop, solar farm, and satellite

NASA Technical Reports Server (NTRS)

Berman, P. A.

1972-01-01

Three major options for wide-scale generation of photovoltaic energy for terrestrial use are considered: (1) rooftop array, (2) solar farm, and (3) satellite station. The rooftop array would use solar cell arrays on the roofs of residential or commercial buildings; the solar farm would consist of large ground-based arrays, probably in arid areas with high insolation; and the satellite station would consist of an orbiting solar array, many square kilometers in area. The technology advancement requirements necessary for each option are discussed, including cost reduction of solar cells and arrays, weight reduction, resistance to environmental factors, reliability, and fabrication capability, including the availability of raw materials. The majority of the technology advancement requirements are applicable to all three options, making possible a flexible basic approach regardless of the options that may eventually be chosen. No conclusions are drawn as to which option is most advantageous, since the feasibility of each option depends on the success achieved in the technology advancement requirements specified.

Space Environment Testing of Photovoltaic Array Systems at NASA's Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Phillips, Brandon S.; Schneider, Todd A.; Vaughn, Jason A.; Wright, Kenneth H., Jr.

2015-01-01

To successfully operate a photovoltaic (PV) array system in space requires planning and testing to account for the effects of the space environment. It is critical to understand space environment interactions not only on the PV components, but also the array substrate materials, wiring harnesses, connectors, and protection circuitry (e.g. blocking diodes). Key elements of the space environment which must be accounted for in a PV system design include: Solar Photon Radiation, Charged Particle Radiation, Plasma, and Thermal Cycling. While solar photon radiation is central to generating power in PV systems, the complete spectrum includes short wavelength ultraviolet components, which photo-ionize materials, as well as long wavelength infrared which heat materials. High energy electron radiation has been demonstrated to significantly reduce the output power of III-V type PV cells; and proton radiation damages material surfaces - often impacting coverglasses and antireflective coatings. Plasma environments influence electrostatic charging of PV array materials, and must be understood to ensure that long duration arcs do not form and potentially destroy PV cells. Thermal cycling impacts all components on a PV array by inducing stresses due to thermal expansion and contraction. Given such demanding environments, and the complexity of structures and materials that form a PV array system, mission success can only be ensured through realistic testing in the laboratory. NASA's Marshall Space Flight Center has developed a broad space environment test capability to allow PV array designers and manufacturers to verify their system's integrity and avoid costly on-orbit failures. The Marshall Space Flight Center test capabilities are available to government, commercial, and university customers. Test solutions are tailored to meet the customer's needs, and can include performance assessments, such as flash testing in the case of PV cells.

Transparent TiO 2 nanotube array photoelectrodes prepared via two-step anodization

DOE PAGES

Kim, Jin Young; Zhu, Kai; Neale, Nathan R.; ...

2014-04-04

Two-step anodization of transparent TiO 2 nanotube arrays has been demonstrated with aid of a Nb-doped TiO 2 buffer layer deposited between the Ti layer and TCO substrate. Enhanced physical adhesion and electrochemical stability provided by the buffer layer has been found to be important for successful implementation of the two-step anodization process. As a result, with the proposed approach, the morphology and thickness of NT arrays could be controlled very precisely, which in turn, influenced their optical and photoelectrochemical properties.

The Constellation-X Focal Plane Microcalorimeter Array: An NTD-Germanium Solution

NASA Technical Reports Server (NTRS)

Beeman, J.; Silver, E.; Bandler, S.; Schnopper, H.; Murray, S.; Madden, N.; Landis, D.; Haller, E. E.; Barbera, M.

2001-01-01

The hallmarks of Neutron Transmutation Doped (NTD) germanium cryogenic thermistors include high reliability, reproducibility, and long term stability of bulk carrier transport properties. Using micro-machined NTD Ge thermistors with integral 'flying' leads, we can now fabricate two-dimensional arrays that are built up from a series of stacked linear arrays. We believe that this modular approach of building, assembling, and perhaps replacing individual modules of detectors is essential to the successful fabrication and testing of large multi-element instruments. Details of construction are presented.

A Mid-scala Cochlear Implant Electrode Design Achieves a Stable Post-surgical Position in the Cochlea of Patients Over Time-A Prospective Observational Study.

PubMed

Dees, Guido; Smits, Jeroen Jules; Janssen, A Miranda L; Hof, Janny R; Gazibegovic, Dzemal; Hoof, Marc van; Stokroos, Robert J

2018-04-01

Cochlear implant (CI) electrode design impacts the clinical performance of patients. Stability and the occurrence of electrode array migration, which is the postoperative movement of the electrode array, were investigated using a mid-scalar electrode array and postoperative image analysis. A prospective observational study was conducted. A mid-scalar electrode was surgically placed using a mastoidectomy, followed by a posterior tympanotomy and an extended round-window or cochleostomy insertion. A few days after surgery and 3 months later Cone Beam Computed Tomography (CBCT) was performed. The two different CBCT's were fused, and the differences between the electrode positions in three dimensions were calculated (the migration). A migration greater than 0.5 mm was deemed clinically relevant. Fourteen subjects participated. The mid-scalar electrode migrated in one patient (7%). This did not lead to the extrusion of an electrode contact. The mean migration of every individual electrode contact in all patients was 0.36 mm (95% confidence interval 0.22-0.50 mm), which approximates to the estimated measurement error of the CBCT technique. A mid-scalar electrode array achieves a stable position in the cochlea in a small but representative group of patients. The methods applied in this work can be used for providing postoperative feedback for surgeons and for benchmarking electrode designs.

High-Resolution Ultrasonic Imaging of Dento-Periodontal Tissues Using a Multi-Element Phased Array System.

PubMed

Nguyen, Kim-Cuong T; Le, Lawrence H; Kaipatur, Neelambar R; Zheng, Rui; Lou, Edmond H; Major, Paul W

2016-10-01

Intraoral ultrasonography uses high-frequency mechanical waves to study dento-periodontium. Besides the advantages of portability and cost-effectiveness, ultrasound technique has no ionizing radiation. Previous studies employed a single transducer or an array of transducer elements, and focused on enamel thickness and distance measurement. This study used a phased array system with a 128-element array transducer to image dento-periodontal tissues. We studied two porcine lower incisors from a 6-month-old piglet using 20-MHz ultrasound. The high-resolution ultrasonographs clearly showed the cross-sectional morphological images of the hard and soft tissues. The investigation used an integration of waveform analysis, travel-time calculation, and wavefield simulation to reveal the nature of the ultrasound data, which makes the study novel. With the assistance of time-distance radio-frequency records, we robustly justified the enamel-dentin interface, dentin-pulp interface, and the cemento-enamel junction. The alveolar crest level, the location of cemento-enamel junction, and the thickness of alveolar crest were measured from the images and compared favorably with those from the cone beam computed tomography with less than 10% difference. This preliminary and fundamental study has reinforced the conclusions from previous studies, that ultrasonography has great potential to become a non-invasive diagnostic imaging tool for quantitative assessment of periodontal structures and better delivery of oral care.

Performance of a high-resolution depth-encoding PET detector module using linearly-graded SiPM arrays

NASA Astrophysics Data System (ADS)

Du, Junwei; Bai, Xiaowei; Gola, Alberto; Acerbi, Fabio; Ferri, Alessandro; Piemonte, Claudio; Yang, Yongfeng; Cherry, Simon R.

2018-02-01

The goal of this study was to exploit the excellent spatial resolution characteristics of a position-sensitive silicon photomultiplier (SiPM) and develop a high-resolution depth-of-interaction (DOI) encoding positron emission tomography (PET) detector module. The detector consists of a 30  ×  30 array of 0.445  ×  0.445  ×  20 mm3 polished LYSO crystals coupled to two 15.5  ×  15.5 mm2 linearly-graded SiPM (LG-SiPM) arrays at both ends. The flood histograms show that all the crystals in the LYSO array can be resolved. The energy resolution, the coincidence timing resolution and the DOI resolution were 21.8  ±  5.8%, 1.23  ±  0.10 ns and 3.8  ±  1.2 mm, respectively, at a temperature of -10 °C and a bias voltage of 35.0 V. The performance did not degrade significantly for event rates of up to 130 000 counts s-1. This detector represents an attractive option for small-bore PET scanner designs that simultaneously emphasize high spatial resolution and high detection efficiency, important, for example, in preclinical imaging of the rodent brain with neuroreceptor ligands.

Application of MEMS Microphone Array Technology to Airframe Noise Measurements

NASA Technical Reports Server (NTRS)

Humphreys, William M., Jr.; Shams, Qamar A.; Graves, Sharon S.; Sealey, Bradley S.; Bartram, Scott M.; Comeaux, Toby

2005-01-01

Current generation microphone directional array instrumentation is capable of extracting accurate noise source location and directivity data on a variety of aircraft components, resulting in significant gains in test productivity. However, with this gain in productivity has come the desire to install larger and more complex arrays in a variety of ground test facilities, creating new challenges for the designers of array systems. To overcome these challenges, a research study was initiated to identify and develop hardware and fabrication technologies which could be used to construct an array system exhibiting acceptable measurement performance but at much lower cost and with much simpler installation requirements. This paper describes an effort to fabricate a 128-sensor array using commercially available Micro-Electro-Mechanical System (MEMS) microphones. The MEMS array was used to acquire noise data for an isolated 26%-scale high-fidelity Boeing 777 landing gear in the Virginia Polytechnic Institute and State University Stability Tunnel across a range of Mach numbers. The overall performance of the array was excellent, and major noise sources were successfully identified from the measurements.

Space solar array reliability: A study and recommendations

NASA Astrophysics Data System (ADS)

Brandhorst, Henry W., Jr.; Rodiek, Julie A.

2008-12-01

Providing reliable power over the anticipated mission life is critical to all satellites; therefore solar arrays are one of the most vital links to satellite mission success. Furthermore, solar arrays are exposed to the harshest environment of virtually any satellite component. In the past 10 years 117 satellite solar array anomalies have been recorded with 12 resulting in total satellite failure. Through an in-depth analysis of satellite anomalies listed in the Airclaim's Ascend SpaceTrak database, it is clear that solar array reliability is a serious, industry-wide issue. Solar array reliability directly affects the cost of future satellites through increased insurance premiums and a lack of confidence by investors. Recommendations for improving reliability through careful ground testing, standardization of testing procedures such as the emerging AIAA standards, and data sharing across the industry will be discussed. The benefits of creating a certified module and array testing facility that would certify in-space reliability will also be briefly examined. Solar array reliability is an issue that must be addressed to both reduce costs and ensure continued viability of the commercial and government assets on orbit.

Implementation and Performance of GaAs Digital Signal Processing ASICs

NASA Technical Reports Server (NTRS)

Whitaker, William D.; Buchanan, Jeffrey R.; Burke, Gary R.; Chow, Terrance W.; Graham, J. Scott; Kowalski, James E.; Lam, Barbara; Siavoshi, Fardad; Thompson, Matthew S.; Johnson, Robert A.

1993-01-01

The feasibility of performing high speed digital signal processing in GaAs gate array technology has been demonstrated with the successful implementation of a VLSI communications chip set for NASA's Deep Space Network. This paper describes the techniques developed to solve some of the technology and implementation problems associated with large scale integration of GaAs gate arrays.

Acoustic Source Elevation Angle Estimates Using Two Microphones

DTIC Science & Technology

2014-06-01

elevated. Elevation angles are successfully estimated, under certain conditions, for a loudspeaker broadcasting band limited white noise. 15. SUBJECT...INTENTIONALLY LEFT BLANK. 1 1. Introduction The U.S. Army uses acoustic arrays to track and locate various sources including...ground and airborne vehicles, small arms, mortars, and rockets. The tracking and locating algorithms often used with these acoustic arrays perform

Dual-Energy Computed Tomography Angiography of the Head and Neck With Single-Source Computed Tomography: A New Technical (Split Filter) Approach for Bone Removal.

PubMed

Kaemmerer, Nadine; Brand, Michael; Hammon, Matthias; May, Matthias; Wuest, Wolfgang; Krauss, Bernhard; Uder, Michael; Lell, Michael M

2016-10-01

Dual-energy computed tomographic angiography (DE-CTA) has been demonstrated to improve the visualization of the head and neck vessels. The aim of this study was to test the potential of split-filter single-source dual-energy CT to automatically remove bone from the final CTA data set. Dual-energy CTA was performed in 50 consecutive patients to evaluate the supra-aortic arteries, either to grade carotid artery stenosis or to rule out traumatic dissections. Dual-energy CTA was performed on a 128-slice single-source CT system equipped with a special filter array to separate the 120-kV spectrum into a high- and a low-energy spectrum for DE-based automated bone removal. Image quality of fully automated bone suppression and subsequent manual optimization was evaluated by 2 radiologists on maximum intensity projections using a 4-grade scoring system. The effect of image reconstruction with an iterative metal artifact reduction algorithm on DE postprocessing was tested using a 3-grade scoring system, and the time demand for each postprocessing step was measured. Two patients were excluded due to insufficient arterial contrast enhancement; in the remaining 48 patients, automated bone removal could be performed successfully. The addition of iterative metal artifact reduction algorithm improved image quality in 58.3% of the cases. After manual optimization, DE-CTA image quality was rated excellent in 7, good in 29, and moderate in 10 patients. Interobserver agreement was high (κ = 0.85). Stenosis grading was not influenced using DE-CTA with bone removal as compared with the original CTA. The time demand for DE image reconstruction was significantly higher than for single-energy reconstruction (42.1 vs 20.9 seconds). Our results suggest that bone removal in DE-CTA of the head and neck vessels with a single-source CT is feasible and can be performed within acceptable time and moderate user interaction.

High efficiency microfluidic beta detector for pharmacokinetic studies in small animals

NASA Astrophysics Data System (ADS)

Convert, Laurence; Girard-Baril, Frédérique; Renaudin, Alan; Grondin, Étienne; Jaouad, Abdelatif; Aimez, Vincent; Charette, Paul; Lecomte, Roger

2011-10-01

New radiotracers are continuously being developed to improve diagnostic efficiency using Single Photon Emission Computed Tomography (SPECT) or Positron Emission Tomography (PET). The characterization of their pharmacokinetics requires blood radioactivity monitoring over time during the scan and is very challenging in small animals because of the low volume of blood available. In this work, a prototype microfluidic blood counter made of a microchannel atop a silicon substrate containing PIN photodiodes is proposed to improve beta detection efficiency in a small volume by eliminating unnecessary interfaces between fluid and detector. A flat rectangular-shaped epoxy channel, 36 μm×1.26 mm cross section and 31.5 mm in length, was microfabricated over a die containing an array of 2×2 mm 2 PIN photodiodes, leaving only a few micrometers of epoxy floor layer between the fluid and the photodiode sensitive surface. This geometry leads to a quasi 2D source, optimizing geometrical detection efficiency that was estimated at 41% using solid angle calculation. CV- IV measurements were made at each fabrication step to confirm that the microchannel components had no significant effects on the diodes' electrical characteristics. The chip was wire-bonded to a PCB and connected to charge sensitive preamplifier and amplifier modules for pulse shaping. Energy spectra recorded for different isotopes showed continuous beta distribution for PET isotopes and monoenergetic conversion electron peaks for 99mTc. Absolute sensitivity was determined for the most popular PET and SPECT radioisotopes and ranged from 26% to 33% for PET tracers ( 18F, 13N, 11C, 68Ga) and more than 2% for 99mTc. Input functions were successfully simulated with 18F, confirming the setup's suitability for pharmacokinetic modeling of PET and SPECT radiotracers in animal experiments. By using standard materials and procedures, the fabrication process is well suited to on-chip microfluidic functionality, allowing full characterization of new radiotracers.

Functionalized vertical GaN micro pillar arrays with high signal-to-background ratio for detection and analysis of proteins secreted from breast tumor cells.

PubMed

Choi, Mun-Ki; Kim, Gil-Sung; Jeong, Jin-Tak; Lim, Jung-Taek; Lee, Won-Yong; Umar, Ahmad; Lee, Sang-Kwon

2017-11-02

The detection of cancer biomarkers has recently attracted significant attention as a means of determining the correct course of treatment with targeted therapeutics. However, because the concentration of these biomarkers in blood is usually relatively low, highly sensitive biosensors for fluorescence imaging and precise detection are needed. In this study, we have successfully developed vertical GaN micropillar (MP) based biosensors for fluorescence sensing and quantitative measurement of CA15-3 antigens. The highly ordered vertical GaN MP arrays result in the successful immobilization of CA15-3 antigens on each feature of the arrays, thereby allowing the detection of an individual fluorescence signal from the top surface of the arrays owing to the high regularity of fluorophore-tagged MP spots and relatively low background signal. Therefore, our fluorescence-labeled and CA15-3 functionalized vertical GaN-MP-based biosensor is suitable for the selective quantitative analysis of secreted CA15-3 antigens from MCF-7 cell lines, and helps in the early diagnosis and prognosis of serious diseases as well as the monitoring of the therapeutic response of breast cancer patients.

Electromagnetic Navigational Bronchoscopy Reduces the Time Required for Localization and Resection of Lung Nodules.

PubMed

Bolton, William David; Cochran, Thomas; Ben-Or, Sharon; Stephenson, James E; Ellis, William; Hale, Allyson L; Binks, Andrew P

The aims of the study were to evaluate electromagnetic navigational bronchoscopy (ENB) and computed tomography-guided placement as localization techniques for minimally invasive resection of small pulmonary nodules and determine whether electromagnetic navigational bronchoscopy is a safer and more effective method than computed tomography-guided localization. We performed a retrospective review of our thoracic surgery database to identify patients who underwent minimally invasive resection for a pulmonary mass and used either electromagnetic navigational bronchoscopy or computed tomography-guided localization techniques between July 2011 and May 2015. Three hundred eighty-three patients had a minimally invasive resection during our study period, 117 of whom underwent electromagnetic navigational bronchoscopy or computed tomography localization (electromagnetic navigational bronchoscopy = 81; computed tomography = 36). There was no significant difference between computed tomography and electromagnetic navigational bronchoscopy patient groups with regard to age, sex, race, pathology, nodule size, or location. Both computed tomography and electromagnetic navigational bronchoscopy were 100% successful at localizing the mass, and there was no difference in the type of definitive surgical resection (wedge, segmentectomy, or lobectomy) (P = 0.320). Postoperative complications occurred in 36% of all patients, but there were no complications related to the localization procedures. In terms of localization time and surgical time, there was no difference between groups. However, the down/wait time between localization and resection was significant (computed tomography = 189 minutes; electromagnetic navigational bronchoscopy = 27 minutes); this explains why the difference in total time (sum of localization, down, and surgery) was significant (P < 0.001). We found electromagnetic navigational bronchoscopy to be as safe and effective as computed tomography-guided wire placement and to provide a significantly decreased down time between localization and surgical resection.

Combination of short-length TiO2 nanorod arrays and compact PbS quantum-dot thin films for efficient solid-state quantum-dot-sensitized solar cells

NASA Astrophysics Data System (ADS)

Zhang, Zhengguo; Shi, Chengwu; Chen, Junjun; Xiao, Guannan; Li, Long

2017-07-01

Considering the balance of the hole diffusion length and the loading quantity of quantum-dots, the rutile TiO2 nanorod array with the length of 600 nm, the diameter of 20 nm, and the areal density of 500 μm-2 is successfully prepared by the hydrothermal method using the aqueous grown solution of 38 mM titanium isopropoxide and 6 M hydrochloric acid at 170 °C for 105 min. The compact PbS quantum-dot thin film on the TiO2 nanorod array is firstly obtained by the spin-coating-assisted successive ionic layer absorption and reaction with using 1,2-ethanedithiol (EDT). The result reveals that the strong interaction between lead and EDT is very important to control the crystallite size of PbS quantum-dots and obtain the compact PbS quantum-dot thin film on the TiO2 nanorod array. The all solid-state sensitized solar cell with the combination of the short-length, high-density TiO2 nanorod array and the compact PbS quantum-dot thin film achieves the photoelectric conversion efficiency of 4.10%, along with an open-circuit voltage of 0.52 V, a short-circuit photocurrent density of 13.56 mA cm-2 and a fill factor of 0.58.

ACTS Battery and Solar Array Assembly On-Orbit Measured Performance

NASA Technical Reports Server (NTRS)

Hilderman, Don R.

2005-01-01

The Advanced Communications Technology Satellite (ACTS) is a NASA experimental communications satellite system designed to demonstrate on-orbit Ka-band communications and switching technologies that will be used by NASA and the commercial sector in the 21st century. The ACTS was launched on September 12, 1993, and has performed over 10 years of successful experimental operations. The purpose of this report is to describe the ACTS power subsystem and the ACTS solar array and battery assemblies located within the power subsystem and then to document on-orbit measured performance from launch to mission end on April 28, 2004. Solar array and battery performance data is presented, and respective conclusions are drawn. The total solar array power available to the spacecraft was measured each year at the same time, and battery voltage performance was measured twice per year at the same times during peak solar eclipse. At the highest spacecraft power demand, the ACTS uses approximately 1113 W of electrical power during the low-burstrate experiment to operate all six satellite subsystems. After 10 years of on-orbit operation, solar array available output power normal to the Sun measured 1508 W, which represents 395 W of excess margin. The ACTS batteries have successfully supported the ACTS experiment program for over 10 years and operated in excess of 900 charge and discharge cycles through 21 eclipse seasons.

Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease.

PubMed

Piwnica-Worms, David; Kesarwala, Aparna H; Pichler, Andrea; Prior, Julie L; Sharma, Vijay

2006-11-01

Overexpression of multi-drug resistant P-glycoprotein (Pgp) remains an important barrier to successful chemotherapy in cancer patients and impacts the pharmacokinetics of many important drugs. Pgp is also expressed on the luminal surface of brain capillary endothelial cells wherein Pgp functionally comprises a major component of the blood-brain barrier by limiting central nervous system penetration of various therapeutic agents. In addition, Pgp in brain capillary endothelial cells removes amyloid-beta from the brain. Several single photon emission computed tomography and positron emission tomography radiopharmaceutical have been shown to be transported by Pgp, thereby enabling the noninvasive interrogation of Pgp-mediated transport activity in vivo. Therefore, molecular imaging of Pgp activity may enable noninvasive dynamic monitoring of multi-drug resistance in cancer, guide therapeutic choices in cancer chemotherapy, and identify transporter deficiencies of the blood-brain barrier in Alzheimer's disease.

Round window electrode insertion potentiates retention in the scala tympani.

PubMed

Connor, Stephen E J; Holland, N Julian; Agger, Andreas; Leong, Annabelle C; Varghese, Re Ajay; Jiang, Dan; Fitzgerald O'Connor, Alec

2012-09-01

The round window membrane (RWM)-intentioned approach is superior to the traditional bony cochleostomy (BC) approach in obtaining electrode placement within the scala tympani (ST). Cochlear implant outcome is influenced by several factors, including optimal placement and retention of the electrode array within the ST. The present study aimed to assess whether the RWM route is superior to a traditional BC for placement and retention of the electrode array in the ST. This was a prospective consecutive non-randomized comparison study. All patients were implanted with the Advanced Bionics 1J electrode array. The RWM approach (n = 32) was compared with a traditional BC group (n = 33). The outcome measure was the electrode position as judged within the scalar chambers at four points along the basal turn using postoperative computed tomography (CT). When the mean position scores were compared, the RWM-intentioned group had significantly more electrodes directed towards the ST compartment than the BC group (p < 0.001). The RWM electrodes achieved 94% ST retention compared with 64% for the BC group (p < 0.05). All electrodes stayed in the ST in the RWM group, whereas in the BC group 9% crossed from the ST to the scala vestibuli.

In vivo photothermal treatment with real-time monitoring by optical fiber-needle array.

PubMed

Yang, Taeseok Daniel; Park, Kwanjun; Kim, Hyung-Jin; Im, Nu-Ri; Kim, Byoungjae; Kim, TaeHoon; Seo, Sohyun; Lee, Jae-Seung; Kim, Beop-Min; Choi, Youngwoon; Baek, Seung-Kuk

2017-07-01

Photothermal treatment (PTT) using gold nanoshells (gold-NSs) is accepted as a method for treating cancer. However, owing to restrictions in therapeutic depth and skin damage caused by excessive light exposure, its application has been limited to lesions close to the epidermis. Here, we demonstrate an in vivo PTT method that uses gold-NSs with a flexible optical fiber-needle array (OFNA), which is an array of multiple needles in which multimode optical fibers are inserted, one in each, for light delivery. The light for PTT was directly administrated to subcutaneous tissues through the OFNA, causing negligible thermal damage to the skin. Enhancement of light energy delivery assisted by the OFNA in a target area was confirmed by investigation using artificial tissues. The ability of OFNA to treat cancer without causing cutaneous thermal damage was also verified by hematoxylin and eosin (H&E) staining and optical coherence tomography in cancer models in mice. In addition, the OFNA allowed for observation of the target site through an imaging fiber bundle. By imaging the activation of the injected gold-NSs, we were able to obtain information on the PTT process in real-time.

Simultaneous monitoring of multiple contrast agents using a hybrid MR-DOT system

NASA Astrophysics Data System (ADS)

Gulsen, Gultekin; Unlu, Mehmet Burcin; Birgul, Ozlem; Nalcioglu, Orhan

2007-02-01

Frequency domain diffuse optical tomography (DOT) is a recently emerging technique that uses arrays of sources and detectors to obtain spatially dependent optical parameters of tissue. Here, we describe the design of a hybrid MR-DOT system for dynamic imaging cancer. The combined system acquires both MR and optical data simultaneously. The performance of the system is tested with phantom and in-vivo studies. Gd-DTPA and ICG was used for this purpose and the enhancement kinetics of both agents are recorded using the hybrid system.

A micro-CL system and its applications

NASA Astrophysics Data System (ADS)

Wei, Zenghui; Yuan, Lulu; Liu, Baodong; Wei, Cunfeng; Sun, Cuili; Yin, Pengfei; Wei, Long

2017-11-01

The computed laminography (CL) method is preferable to computed tomography for the non-destructive testing of plate-like objects. A micro-CL system is developed for three-dimensional imaging of plate-like objects. The details of the micro-CL system are described, including the system architecture, scanning modes, and reconstruction algorithm. The experiment results of plate-like fossils, insulated gate bipolar translator module, ball grid array packaging, and printed circuit board are also presented to demonstrate micro-CL's ability for 3D imaging of flat specimens and universal applicability in various fields.

A micro-CL system and its applications.

PubMed

Wei, Zenghui; Yuan, Lulu; Liu, Baodong; Wei, Cunfeng; Sun, Cuili; Yin, Pengfei; Wei, Long

2017-11-01

The computed laminography (CL) method is preferable to computed tomography for the non-destructive testing of plate-like objects. A micro-CL system is developed for three-dimensional imaging of plate-like objects. The details of the micro-CL system are described, including the system architecture, scanning modes, and reconstruction algorithm. The experiment results of plate-like fossils, insulated gate bipolar translator module, ball grid array packaging, and printed circuit board are also presented to demonstrate micro-CL's ability for 3D imaging of flat specimens and universal applicability in various fields.

The SAFIR experiment: Concept, status and perspectives

NASA Astrophysics Data System (ADS)

Becker, Robert; Buck, Alfred; Casella, Chiara; Dissertori, Günther; Fischer, Jannis; Howard, Alexander; Ito, Mikiko; Khateri, Parisa; Lustermann, Werner; Oliver, Josep F.; Röser, Ulf; Warnock, Geoffrey; Weber, Bruno

2017-02-01

The SAFIR development represents a novel Positron Emission Tomography (PET) detector, conceived for preclinical fast acquisitions inside the bore of a Magnetic Resonance Imaging (MRI) scanner. The goal is hybrid and simultaneous PET/MRI dynamic studies at unprecedented temporal resolutions of a few seconds. The detector relies on matrices of scintillating LSO-based crystals coupled one-to-one with SiPM arrays and readout by fast ASICs with excellent timing resolution and high rate capabilities. The paper describes the detector concept and the initial results in terms of simulations and characterisation measurements.

The Use of a Pressure-Indicating Sensor Film to Provide Feedback upon Hydrogel-Forming Microneedle Array Self-Application In Vivo.

PubMed

Vicente-Pérez, Eva M; Quinn, Helen L; McAlister, Emma; O'Neill, Shannon; Hanna, Lezley-Anne; Barry, Johanne G; Donnelly, Ryan F

2016-12-01

To evaluate the combination of a pressure-indicating sensor film with hydrogel-forming microneedle arrays, as a method of feedback to confirm MN insertion in vivo. Pilot in vitro insertion studies were conducted using a Texture Analyser to insert MN arrays, coupled with a pressure-indicating sensor film, at varying forces into excised neonatal porcine skin. In vivo studies involved twenty human volunteers, who self-applied two hydrogel-forming MN arrays, one with a pressure-indicating sensor film incorporated and one without. Optical coherence tomography was employed to measure the resulting penetration depth and colorimetric analysis to investigate the associated colour change of the pressure-indicating sensor film. Microneedle insertion was achieved in vitro at three different forces, demonstrating the colour change of the pressure-indicating sensor film upon application of increasing pressure. When self-applied in vivo, there was no significant difference in the microneedle penetration depth resulting from each type of array, with a mean depth of 237 μm recorded. When the pressure-indicating sensor film was present, a colour change occurred upon each application, providing evidence of insertion. For the first time, this study shows how the incorporation of a simple, low-cost pressure-indicating sensor film can indicate microneedle insertion in vitro and in vivo, providing visual feedback to assure the user of correct application. Such a strategy may enhance usability of a microneedle device and, hence, assist in the future translation of the technology to widespread clinical use.

Three-dimensional tomographic imaging for dynamic radiation behavior study using infrared imaging video bolometers in large helical device plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sano, Ryuichi; Iwama, Naofumi; Peterson, Byron J.

A three-dimensional (3D) tomography system using four InfraRed imaging Video Bolometers (IRVBs) has been designed with a helical periodicity assumption for the purpose of plasma radiation measurement in the large helical device. For the spatial inversion of large sized arrays, the system has been numerically and experimentally examined using the Tikhonov regularization with the criterion of minimum generalized cross validation, which is the standard solver of inverse problems. The 3D transport code EMC3-EIRENE for impurity behavior and related radiation has been used to produce phantoms for numerical tests, and the relative calibration of the IRVB images has been carried outmore » with a simple function model of the decaying plasma in a radiation collapse. The tomography system can respond to temporal changes in the plasma profile and identify the 3D dynamic behavior of radiation, such as the radiation enhancement that starts from the inboard side of the torus, during the radiation collapse. The reconstruction results are also consistent with the output signals of a resistive bolometer. These results indicate that the designed 3D tomography system is available for the 3D imaging of radiation. The first 3D direct tomographic measurement of a magnetically confined plasma has been achieved.« less

Indium-111 WBC detection of emphysematous gastritis in pancreatitis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caruana, V.; Swayne, L.C.; Salaki, J.S.

1990-01-01

We present a case of emphysematous gastritis initially detected with 111In oxine-labeled white blood cell scintigraphy and subsequently confirmed by computed tomography. Early aggressive antibiotic and supportive therapy resulted in a successful clinical outcome.

Successful treatment of tumor-induced osteomalacia with CT-guided percutaneous ethanol and cryoablation.

PubMed

Tutton, Sean; Olson, Erik; King, David; Shaker, Joseph L

2012-10-01

Tumor-induced osteomalacia is a rare condition usually caused by benign mesenchymal tumors. When the tumor can be found, patients are usually managed by wide excision of the tumor. We report a 51-yr-old male with clinical and biochemical evidence of tumor-induced osteomalacia caused by a mesenchymal tumor in the right iliac bone. He declined surgery and appears to have been successfully managed by computed tomography-guided percutaneous ethanol ablation and percutaneous cryoablation. Our patient appears to have had an excellent clinical and biochemical response to computed tomography-guided percutaneous ethanol ablation and percutaneous cryoablation. We found one prior case of image-guided ablation using radiofrequency ablation for tumor-induced osteomalacia. Although the standard treatment for tumor-induced osteomalacia is wide excision of the tumor, image-guided ablation may be an option in patients who cannot have appropriate surgery or who decline surgery.

ISS Solar Array Management

NASA Technical Reports Server (NTRS)

Williams, James P.; Martin, Keith D.; Thomas, Justin R.; Caro, Samuel

2010-01-01

The International Space Station (ISS) Solar Array Management (SAM) software toolset provides the capabilities necessary to operate a spacecraft with complex solar array constraints. It monitors spacecraft telemetry and provides interpretations of solar array constraint data in an intuitive manner. The toolset provides extensive situational awareness to ensure mission success by analyzing power generation needs, array motion constraints, and structural loading situations. The software suite consists of several components including samCS (constraint set selector), samShadyTimers (array shadowing timers), samWin (visualization GUI), samLock (array motion constraint computation), and samJet (attitude control system configuration selector). It provides high availability and uptime for extended and continuous mission support. It is able to support two-degrees-of-freedom (DOF) array positioning and supports up to ten simultaneous constraints with intuitive 1D and 2D decision support visualizations of constraint data. Display synchronization is enabled across a networked control center and multiple methods for constraint data interpolation are supported. Use of this software toolset increases flight safety, reduces mission support effort, optimizes solar array operation for achieving mission goals, and has run for weeks at a time without issues. The SAM toolset is currently used in ISS real-time mission operations.

Flexible Sensing Arrays Fabricated with Carbon Nanofiber Composite Thin Films for Posture Monitoring

NASA Astrophysics Data System (ADS)

Chang, Fuh-Yu; Wang, Ruoh-Huey; Lin, Yu-Hsien; Chen, Tse-Min; Lee, Yueh-Feng; Huang, Shu-Jiuan; Liu, Chia-Ming

2011-06-01

Faulty posture increases joint stress and causes postural pain syndrome. In this paper, we present a portable strain sensing system with flexible sensor arrays to warn patients to correct inappropriate posture. A 3×3 flexible strain sensing array system was fabricated using patterned surface treatment and the tilted-drop process with carbon nanofiber composite solutions on polyimide substrates. Atmospheric plasma was used to enhance or reduce the surface energy in specific areas for patterned surface treatment. A scanning circuit was also developed to capture the signal from the flexible sensing array. The developed system has been used to measure the bent angle of the human neck from 15 to 60°. The results indicate that human posture can be successfully captured by analyzing the measured strains from a flexible strain sensing array.

Engineering of highly ordered TiO2 nanopore arrays by anodization

NASA Astrophysics Data System (ADS)

Wang, Huijie; Huang, Zhennan; Zhang, Li; Ding, Jie; Ma, Zhaoxia; Liu, Yong; Kou, Shengzhong; Yang, Hangsheng

2016-07-01

Finite element analysis was used to simulate the current density distributions in the TiO2 barrier layer formed at the initial stage of Ti anodization. The morphology modification of the barrier layer was found to induce current density distribution change. By starting the anodization with proper TiO2 barrier layer morphology, the current density distribution can be adjusted to favor the formation of either nanotube arrays or nanopore arrays of anodic TiO2. We also found that the addition of sodium acetate into the electrolyte suppressed both the field-assisted chemical dissolution of TiO2 and the TiF62- hydrolysis induced TiO2 deposition during anodization, and thus further favored the nanopore formation. Accordingly, highly ordered anodic TiO2 nanopore arrays, similar to anodic aluminum oxide nanopore arrays, were successfully prepared.

Six-dimensional real and reciprocal space small-angle X-ray scattering tomography

NASA Astrophysics Data System (ADS)

Schaff, Florian; Bech, Martin; Zaslansky, Paul; Jud, Christoph; Liebi, Marianne; Guizar-Sicairos, Manuel; Pfeiffer, Franz

2015-11-01

When used in combination with raster scanning, small-angle X-ray scattering (SAXS) has proven to be a valuable imaging technique of the nanoscale, for example of bone, teeth and brain matter. Although two-dimensional projection imaging has been used to characterize various materials successfully, its three-dimensional extension, SAXS computed tomography, poses substantial challenges, which have yet to be overcome. Previous work using SAXS computed tomography was unable to preserve oriented SAXS signals during reconstruction. Here we present a solution to this problem and obtain a complete SAXS computed tomography, which preserves oriented scattering information. By introducing virtual tomography axes, we take advantage of the two-dimensional SAXS information recorded on an area detector and use it to reconstruct the full three-dimensional scattering distribution in reciprocal space for each voxel of the three-dimensional object in real space. The presented method could be of interest for a combined six-dimensional real and reciprocal space characterization of mesoscopic materials with hierarchically structured features with length scales ranging from a few nanometres to a few millimetres—for example, biomaterials such as bone or teeth, or functional materials such as fuel-cell or battery components.

Six-dimensional real and reciprocal space small-angle X-ray scattering tomography.

PubMed

Schaff, Florian; Bech, Martin; Zaslansky, Paul; Jud, Christoph; Liebi, Marianne; Guizar-Sicairos, Manuel; Pfeiffer, Franz

2015-11-19

When used in combination with raster scanning, small-angle X-ray scattering (SAXS) has proven to be a valuable imaging technique of the nanoscale, for example of bone, teeth and brain matter. Although two-dimensional projection imaging has been used to characterize various materials successfully, its three-dimensional extension, SAXS computed tomography, poses substantial challenges, which have yet to be overcome. Previous work using SAXS computed tomography was unable to preserve oriented SAXS signals during reconstruction. Here we present a solution to this problem and obtain a complete SAXS computed tomography, which preserves oriented scattering information. By introducing virtual tomography axes, we take advantage of the two-dimensional SAXS information recorded on an area detector and use it to reconstruct the full three-dimensional scattering distribution in reciprocal space for each voxel of the three-dimensional object in real space. The presented method could be of interest for a combined six-dimensional real and reciprocal space characterization of mesoscopic materials with hierarchically structured features with length scales ranging from a few nanometres to a few millimetres--for example, biomaterials such as bone or teeth, or functional materials such as fuel-cell or battery components.

Simultaneous acquisition of magnetic resonance spectroscopy (MRS) data and positron emission tomography (PET) images with a prototype MR-compatible, small animal PET imager

NASA Astrophysics Data System (ADS)

Raylman, Raymond R.; Majewski, Stan; Velan, S. Sendhil; Lemieux, Susan; Kross, Brian; Popov, Vladimir; Smith, Mark F.; Weisenberger, Andrew G.

2007-06-01

Multi-modality imaging (such as PET-CT) is rapidly becoming a valuable tool in the diagnosis of disease and in the development of new drugs. Functional images produced with PET, fused with anatomical images created by MRI, allow the correlation of form with function. Perhaps more exciting than the combination of anatomical MRI with PET, is the melding of PET with MR spectroscopy (MRS). Thus, two aspects of physiology could be combined in novel ways to produce new insights into the physiology of normal and pathological processes. Our team is developing a system to acquire MRI images and MRS spectra, and PET images contemporaneously. The prototype MR-compatible PET system consists of two opposed detector heads (appropriate in size for small animal imaging), operating in coincidence mode with an active field-of-view of ˜14 cm in diameter. Each detector consists of an array of LSO detector elements coupled through a 2-m long fiber optic light guide to a single position-sensitive photomultiplier tube. The use of light guides allows these magnetic field-sensitive elements of the PET imager to be positioned outside the strong magnetic field of our 3T MRI scanner. The PET scanner imager was integrated with a 12-cm diameter, 12-leg custom, birdcage coil. Simultaneous MRS spectra and PET images were successfully acquired from a multi-modality phantom consisting of a sphere filled with 17 brain relevant substances and a positron-emitting radionuclide. There were no significant changes in MRI or PET scanner performance when both were present in the MRI magnet bore. This successful initial test demonstrates the potential for using such a multi-modality to obtain complementary MRS and PET data.

Development of Infrared Phase Closure Capability in the Infrared-Optical Telescope Array (IOTA)

NASA Technical Reports Server (NTRS)

Traub, Wesley A.

2002-01-01

We completed all major fabrication and testing for the third telescope and phase-closure operation at the Infrared-Optical Telescope Array (IOTA) during this period. In particular we successfully tested the phase-closure operation, using a laboratory light source illuminating the full delay-line optical paths, and using an integrated-optic beam combiner coupled to our Picnic-detector camera. This demonstration is an important and near-final milestone achievement. As of this writing, however, several tasks yet remain, owing to development snags and weather, so the final proof of success, phase-closure observation of a star, is now expected to occur in early 2002, soon after this report has been submitted.

Advanced Antenna Design for NASA's EcoSAR Instrument

NASA Technical Reports Server (NTRS)

Du Toit, Cornelis F.; Deshpande, Manohar; Rincon, Rafael F.

2016-01-01

Advanced antenna arrays were designed for NASA's EcoSAR airborne radar instrument. EcoSAR is a beamforming synthetic aperture radar instrument designed to make polarimetric and "single pass" interferometric measurements of Earth surface parameters. EcoSAR's operational requirements of a 435MHz center frequency with up to 200MHz bandwidth, dual polarization, high cross-polarization isolation (> 30 dB), +/- 45deg beam scan range and antenna form-factor constraints imposed stringent requirements on the antenna design. The EcoSAR project successfully developed, characterized, and tested two array antennas in an anechoic chamber. EcoSAR's first airborne campaign conducted in the spring of 2014 generated rich data sets of scientific and engineering value, demonstrating the successful operation of the antennas.

Eclipse SteerTech liquid lenslet beam steering technology

NASA Astrophysics Data System (ADS)

Westfall, Raymond T.; Rogers, Stanley; Shannon, Kenneth C., III

2007-09-01

Eclipse SteerTech TM transmissive fluid state electrowetting technology has successfully demonstrated the ability to control the shape and position of a fluid lenslet. In its final form, the technology will incorporate a dual fluid lenslet approach capable of operating in extremely high acceleration environments. The beam steering system works on the principle of electro-wetting. A substrate is covered with a closely spaced array of, independently addressable, transparent, electrically conductive pixels utilizing Eclipse's proprietary EclipseTEC TM technology. By activating and deactivating selected EclipseTEC TM pixels in the proper sequence, the shape and position of fluid lenslets or arrays of lenslets can be dynamically changed at will. The position and shape of individual fluid lenslets may be accurately controlled on any flat, simply curved, or complex curved, transparent or reflective surface. The smaller the pixels the better control of the position and shape of the fluid lenslets. Information on the successful testing of the Eclipse SteerTech TM lenslet and discussion of its use in a de-centered lenslet array will be presented.

Diazonium Chemistry for the Bio-Functionalization of Glassy Nanostring Resonator Arrays

PubMed Central

Zheng, Wei; Du, Rongbing; Cao, Yong; Mohammad, Mohammad A.; Dew, Steven K.; McDermott, Mark T.; Evoy, Stephane

2015-01-01

Resonant glassy nanostrings have been employed for the detection of biomolecules. These devices offer high sensitivity and amenability to large array integration and multiplexed assays. Such a concept has however been impaired by the lack of stable and biocompatible linker chemistries. Diazonium salt reduction-induced aryl grafting is an aqueous-based process providing strong chemical adhesion. In this work, diazonium-based linker chemistry was performed for the first time on glassy nanostrings, which enabled the bio-functionalization of such devices. Large arrays of nanostrings with ultra-narrow widths down to 10 nm were fabricated employing electron beam lithography. Diazonium modification was first developed on SiCN surfaces and validated by X-ray photoelectron spectroscopy. Similarly modified nanostrings were then covalently functionalized with anti-rabbit IgG as a molecular probe. Specific enumeration of rabbit IgG was successfully performed through observation of downshifts of resonant frequencies. The specificity of this enumeration was confirmed through proper negative control experiments. Helium ion microscopy further verified the successful functionalization of nanostrings. PMID:26263989

Diazonium Chemistry for the Bio-Functionalization of Glassy Nanostring Resonator Arrays.

PubMed

Zheng, Wei; Du, Rongbing; Cao, Yong; Mohammad, Mohammad A; Dew, Steven K; McDermott, Mark T; Evoy, Stephane

2015-07-30

Resonant glassy nanostrings have been employed for the detection of biomolecules. These devices offer high sensitivity and amenability to large array integration and multiplexed assays. Such a concept has however been impaired by the lack of stable and biocompatible linker chemistries. Diazonium salt reduction-induced aryl grafting is an aqueous-based process providing strong chemical adhesion. In this work, diazonium-based linker chemistry was performed for the first time on glassy nanostrings, which enabled the bio-functionalization of such devices. Large arrays of nanostrings with ultra-narrow widths down to 10 nm were fabricated employing electron beam lithography. Diazonium modification was first developed on SiCN surfaces and validated by X-ray photoelectron spectroscopy. Similarly modified nanostrings were then covalently functionalized with anti-rabbit IgG as a molecular probe. Specific enumeration of rabbit IgG was successfully performed through observation of downshifts of resonant frequencies. The specificity of this enumeration was confirmed through proper negative control experiments. Helium ion microscopy further verified the successful functionalization of nanostrings.

Full-field optical coherence tomography image restoration based on Hilbert transformation

NASA Astrophysics Data System (ADS)

Na, Jihoon; Choi, Woo June; Choi, Eun Seo; Ryu, Seon Young; Lee, Byeong Ha

2007-02-01

We propose the envelope detection method that is based on Hilbert transform for image restoration in full-filed optical coherence tomography (FF-OCT). The FF-OCT system presenting a high-axial resolution of 0.9 μm was implemented with a Kohler illuminator based on Linnik interferometer configuration. A 250 W customized quartz tungsten halogen lamp was used as a broadband light source and a CCD camera was used as a 2-dimentional detector array. The proposed image restoration method for FF-OCT requires only single phase-shifting. By using both the original and the phase-shifted images, we could remove the offset and the background signals from the interference fringe images. The desired coherent envelope image was obtained by applying Hilbert transform. With the proposed image restoration method, we demonstrate en-face imaging performance of the implemented FF-OCT system by presenting a tilted mirror surface, an integrated circuit chip, and a piece of onion epithelium.

Digitally balanced detection for optical tomography.

PubMed

Hafiz, Rehan; Ozanyan, Krikor B

2007-10-01

Analog balanced Photodetection has found extensive usage for sensing of a weak absorption signal buried in laser intensity noise. This paper proposes schemes for compact, affordable, and flexible digital implementation of the already established analog balanced detection, as part of a multichannel digital tomography system. Variants of digitally balanced detection (DBD) schemes, suitable for weak signals on a largely varying background or weakly varying envelopes of high frequency carrier waves, are introduced analytically and elaborated in terms of algorithmic and hardware flow. The DBD algorithms are implemented on a low-cost general purpose reconfigurable hardware (field-programmable gate array), utilizing less than half of its resources. The performance of the DBD schemes compare favorably with their analog counterpart: A common mode rejection ratio of 50 dB was observed over a bandwidth of 300 kHz, limited mainly by the host digital hardware. The close relationship between the DBD outputs and those of known analog balancing circuits is discussed in principle and shown experimentally in the example case of propane gas detection.

Imaging fast electrical activity in the brain with electrical impedance tomography

PubMed Central

Aristovich, Kirill Y.; Packham, Brett C.; Koo, Hwan; Santos, Gustavo Sato dos; McEvoy, Andy; Holder, David S.

2016-01-01

Imaging of neuronal depolarization in the brain is a major goal in neuroscience, but no technique currently exists that could image neural activity over milliseconds throughout the whole brain. Electrical impedance tomography (EIT) is an emerging medical imaging technique which can produce tomographic images of impedance changes with non-invasive surface electrodes. We report EIT imaging of impedance changes in rat somatosensory cerebral cortex with a resolution of 2 ms and < 200 μm during evoked potentials using epicortical arrays with 30 electrodes. Images were validated with local field potential recordings and current source-sink density analysis. Our results demonstrate that EIT can image neural activity in a volume 7 × 5 × 2 mm in somatosensory cerebral cortex with reduced invasiveness, greater resolution and imaging volume than other methods. Modeling indicates similar resolutions are feasible throughout the entire brain so this technique, uniquely, has the potential to image functional connectivity of cortical and subcortical structures. PMID:26348559

Radiology of colorectal cancer.

PubMed

Pijl, M E J; Chaoui, A S; Wahl, R L; van Oostayen, J A

2002-05-01

In the past 20 years, the radiology of colorectal cancer has evolved from the barium enema to advanced imaging modalities like phased array magnetic resonance imaging (MRI), virtual colonoscopy and positron emission tomography (PET). Nowadays, primary rectal cancers are preferably imaged with transrectal ultrasound or MRI, while barium enema is still the most often used technique for imaging of colonic cancers. Virtual colonoscopy is rapidly evolving and might considerably change the imaging of colorectal cancer in the near future. The use of virtual colonoscopy for screening purposes and imaging of the colon in occlusive cancer or incomplete colonoscopies is currently under evaluation. The main role of PET is in detecting tumour recurrences, both locally and distantly. Techniques to fuse cross-sectional anatomical (computer tomography (CT) and MRI) and functional (PET) images are being developed. Apart from diagnostic imaging, the radiologists has added image-guided minimally invasive treatments of colorectal liver metastases to their arsenal. The radio-frequency ablation technique is now widely available, and can be used during laparotomy or percutaneously in selected cases.

Anatomical and metabolic small-animal whole-body imaging using ring-shaped confocal photoacoustic computed tomography

NASA Astrophysics Data System (ADS)

Xia, Jun; Chatni, Muhammad; Maslov, Konstantin; Wang, Lihong V.

2013-03-01

Due to the wide use of animals for human disease studies, small animal whole-body imaging plays an increasingly important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose metabolic information, leading to higher costs of building dual-modality systems. Even with image coregistration, the spatial resolution of the metabolic imaging modality is not improved. We present a ring-shaped confocal photoacoustic computed tomography (RC-PACT) system that can provide both assessments in a single modality. Utilizing the novel design of confocal full-ring light delivery and ultrasound transducer array detection, RC-PACT provides full-view cross-sectional imaging with high spatial resolution. Scanning along the orthogonal direction provides three-dimensional imaging. While the mouse anatomy was imaged with endogenous hemoglobin contrast, the glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose. Through mouse tumor models, we demonstrate that RC-PACT may be a paradigm shifting imaging method for preclinical research.

Investigation of second harmonic generation and multispectral imaging as new contrast mechanisms in scanning laser optical tomography

NASA Astrophysics Data System (ADS)

Nolte, Lena; Antonopoulos, Georgios C.; Heisterkamp, Alexander; Ripken, Tammo; Meyer, Heiko

2018-02-01

Scanning laser optical tomography (SLOT) is a 3D imaging technique, based on the principle of computed tomography to visualize samples up to magnitude of several centimeters. Intrinsic contrast mechanisms as absorption, scattering and autofluorescence provide information about the 3D architecture and composition of the sample. Another valuable intrinsic contrast mechanism is second harmonic generation (SHG), which is generated in noncentrosymmetric materials and commonly used to image collagen in biological samples. The angular dependence of the SHG signal, however, produces artifacts in reconstructed optical tomography datasets (OPT, SLOT). Thus, successful use of this intrinsic contrast mechanism is impaired. We investigate these artifacts by simulation and experiment and propose an elimination procedure that enables successful reconstruction of SHG-SLOT data. Nevertheless, in many cases specific labeling of certain structures is necessary to make them visible. Using multiple dyes in one sample can lead to crosstalk between the different channels and reduce contrast of the images. Also autofluorescence of the sample itself can account for that. By using multispectral imaging in combination with spectral unmixing techniques, this loss can be compensated. Therefore either a spectrally resolved detection path, or spectrally resolved excitation is required. Therefore we integrated a white supercontinuum light source in our SLOT-setup that enables a spectral selection of the excitation beam and extended the detection path to a four channel setup. This enables the detection of three fluorescence channels and one absorption channel in parallel, and increases the contrast in the reconstructed 3D images significantly.

Novel Multiplex Oligonucleotide-Conjugated Bead Suspension Array for Rapid Identification of Enterovirus 71 Subgenogroups▿ §

PubMed Central

Wu, Y.; Tan, E. L.; Yeo, A.; Chan, K. P.; Nishimura, H.; Cardosa, M. J.; Poh, C. L.; Quak, S. H.; Chow, Vincent T.

2011-01-01

A high-throughput multiplex bead suspension array was developed for the rapid subgenogrouping of EV71 strains, based on single nucleotide polymorphisms observed within the VP1 region with a high sensitivity as low as 1 PFU. Of 33 viral isolates and 55 clinical samples, all EV71 strains were successfully detected and correctly subgenogrouped. PMID:21084510

Design and analysis considerations for deployment mechanisms in a space environment

NASA Technical Reports Server (NTRS)

Vorlicek, P. L.; Gore, J. V.; Plescia, C. T.

1982-01-01

On the second flight of the INTELSAT V spacecraft the time required for successful deployment of the north solar array was longer than originally predicted. The south solar array deployed as predicted. As a result of the difference in deployment times a series of experiments was conducted to locate the cause of the difference. Deployment rate sensitivity to hinge friction and temperature levels was investigated. A digital computer simulation of the deployment was created to evaluate the effects of parameter changes on deployment. Hinge design was optimized for nominal solar array deployment time for future INTELSAT V satellites. The nominal deployment times of both solar arrays on the third flight of INTELSAT V confirms the validity of the simulation and design optimization.

Visualization of Underfill Flow in Ball Grid Array (BGA) using Particle Image Velocimetry (PIV)

NASA Astrophysics Data System (ADS)

Ng, Fei Chong; Abas, Aizat; Abustan, Ismail; Remy Rozainy, Z. Mohd; Abdullah, MZ; Jamaludin, Ali b.; Kon, Sharon Melissa

2018-05-01

This paper presents the experimental methodology using particle image velocimetry (PIV) to study the underfill process of ball grid array (BGA) chip package. PIV is a non-intrusive approach to visualize the flow behavior of underfill across the solder ball array. The BGA model of three different configurations – perimeter, middle empty and full array – were studied in current research. Through PIV experimental works, the underfill velocity distribution and vector fields for each BGA models were successfully obtained. It is found that perimeter has the shortest filling time resulting to a higher underfill velocity. Therefore, it is concluded that the flow behavior of underfill in BGA can be justified thoroughly with the aid of PIV.

Baikal-GVD

NASA Astrophysics Data System (ADS)

Avrorin, A. D.; Avrorin, A. V.; Aynutdinov, V. M.; Bannash, R.; Belolaptikov, I. A.; Brudanin, V. B.; Budnev, N. M.; Danilchenko, I. A.; Demidov, S. V.; Domogatsky, G. V.; Doroshenko, A. A.; Dvornicky, R.; Dyachok, A. N.; Dzhilkibaev, Zh.-A. M.; Fajt, L.; Fialkovsky, S. V.; Gafarov, A. R.; Gaponenko, O. N.; Golubkov, K. V.; Gress, T. I.; Honz, Z.; Kebkal, K. G.; Kebkal, O. G.; Konischev, K. V.; Korobchenko, A. V.; Koshechkin, A. P.; Koshel, F. K.; Kozhin, A. V.; Kulepov, V. F.; Kuleshov, D. A.; Milenin, M. B.; Mirgazov, R. A.; Osipova, E. R.; Panfilov, A. I.; Pan'kov, L. V.; Pliskovsky, E. N.; Rozanov, M. I.; Rjabov, E. V.; Shamakhov, F. A.; Shaybonov, B. A.; Sheifler, A. A.; Shelepov, M. D.; Simkovic, F.; Skurihin, A. V.; Smagina, A. A.; Stekl, I.; Suvorova, O. V.; Tabolenko, V. A.; Tarashansky, B. A.; Yakovlev, S. A.; Zagorodnikov, A. V.; Zurbanov, V. L.

2017-03-01

We present the status of the Gigaton Volume Detector in Lake Baikal (Baikal-GVD) designed for the detection of high energy neutrinos of astrophysical origin. The telescope consists of functionally independent clusters, sub-arrays of optical modules (OMs), which are connected to shore by individual electro-optical cables. During 2015 the GVD demonstration cluster, comprising 192 OMs, has been successfully operated in Lake Baikal. In 2016 this array was upgraded to baseline configuration of GVD cluster with 288 OMs arranged on eight vertical strings. Thus the instrumented water volume has been increased up to about 5.9 Mtons. The array was commissioned in early April 2016 and takes data since then. We describe the configuration and design of the 2016 array. Preliminary results obtained with data recorded in 2015 are also discussed.

STS-120 Mission Specialist Scott Parazynski Repairs ISS Solar Array

NASA Technical Reports Server (NTRS)

2007-01-01

While anchored to a foot restraint on the end of the Orbiter Boom Sensor System (OBSS), astronaut Scott Parazynski, STS-120 mission specialist, participated in the mission's fourth session of extravehicular activity (EVA) while Space Shuttle Discovery was docked with the International Space Station (ISS). During the 7-hour and 19-minute space walk, Parazynski cut a snagged wire and installed homemade stabilizers designed to strengthen the structure and stability of the damaged P6 4B solar array wing. Astronaut Doug Wheelock (out of frame), mission specialist, assisted from the truss by keeping an eye on the distance between Parazynski and the array. Once the repair was complete, flight controllers on the ground successfully completed the deployment of the array.

STS-120 Mission Specialist Scott Parazynski Repairs ISS Solar Array

NASA Technical Reports Server (NTRS)

2006-01-01

While anchored to a foot restraint on the end of the Orbiter Boom Sensor System (OBSS), astronaut Scott Parazynski, STS-120 mission specialist, participated in the mission's fourth session of extravehicular activity (EVA) while Space Shuttle Discovery was docked with the International Space Station (ISS). During the 7-hour and 19-minute space walk, Parazynski cut a snagged wire and installed homemade stabilizers designed to strengthen the structure and stability of the damaged P6 4B solar array wing. Astronaut Doug Wheelock (out of frame), mission specialist, assisted from the truss by keeping an eye on the distance between Parazynski and the array. Once the repair was complete, flight controllers on the ground successfully completed the deployment of the array.

250 kA compact linear transformer driver for wire array z-pinch loads

NASA Astrophysics Data System (ADS)

Bott, S. C.; Haas, D. M.; Madden, R. E.; Ueda, U.; Eshaq, Y.; Collins, G., IV; Gunasekera, K.; Mariscal, D.; Peebles, J.; Beg, F. N.; Mazarakis, M.; Struve, K.; Sharpe, R.

2011-05-01

We present the application of a short rise (˜150ns) 250 kA linear transformer driver (LTD) to wire array z-pinch loads for the first time. The generator is a modification of a previous driver in which a new conical power feed provides a low inductance coupling to wire loads. Performance of the new design using both short circuit and plasma loads is presented and discussed. The final design delivers ˜200kA to a wire array load which is in good agreement with SCREAMER calculations using a simplified representative circuit. Example results demonstrate successful experiments using cylindrical, conical, and inverse wire arrays as well as previously published work on x-pinch loads.

Fabrication and Characterization of Vertically Aligned ZnO Nanorod Arrays via Inverted Monolayer Colloidal Crystals Mask

NASA Astrophysics Data System (ADS)

Chen, Cheng; Ding, Taotao; Qi, Zhiqiang; Zhang, Wei; Zhang, Jun; Xu, Juan; Chen, Jingwen; Dai, Jiangnan; Chen, Changqing

2018-04-01

The periodically ordered ZnO nanorod (NR) arrays have been successfully synthesized via a hydrothermal approach on the silicon substrates by templating of the TiO2 ring deriving from the polystyrene (PS) nanosphere monolayer colloidal crystals (MCC). With the inverted MCC mask, sol-gel-derived ZnO seeds could serve as the periodic nucleation positions for the site-specific growth of ZnO NRs. The large-scale patterned arrays of single ZnO NR with good side-orientation can be readily produced. According to the experimental results, the as-integrated ZnO NR arrays showed an excellent crystal quality and optical property, very suitable for optoelectronic applications such as stimulated emitters and ZnO photonic crystal devices.

The success of opening single chronic total occlusion lesions to improve myocardialviabilitytrial (SOS-COMEDY)

PubMed Central

Huang, Rongchong; Song, Xiantao; Zhang, Haishan; Tian, Wen; Huang, Zheng; Zhang, Xingwei; Yang, Junqing; Zhang, Dongfeng; Wu, Jian; Zhong, Lei; Ting, Henry H.

2018-01-01

Abstract Aims: Success of opening single (SOS)-comedy is a prospective multicenter study to compare the improvement in the decrease of myocardial viability by percutaneous coronary intervention (PCI) with that by optimal medical therapy (OMT) alone in patients with chronic total occlusion (CTO) of a single coronary artery. Methods and results: The risks and the benefits of both options (PCI and OMT) were listed in a CTO decision aid (DA). Eligible participants detected by invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) were divided into PCI or OMT groups according to patients’ choice after shared-decision making process with DA. Participants will undergo positron emission tomography/computed tomography (PET/CT), cardiac magnetic resonance (CMR) and transthoracic echocardiography (TTE), and proceed to ICA and revascularization if possible. Blinded core laboratory interpretation will be performed for ICA, CCTA, PET/CT, CMR, and TTE. All participants will be followed up for 12 months. The primary endpoint is the improvement to the decrease of myocardial viability from baseline assessed with the use of PET/CT after 12-month follow-up. Conclusions: All of the patients are appropriately consented before enrolling in this study, which has been approved by the Ethics Committee. Results of SOS-COMEDY will be helpful to develop a strategy for single CTO patients. PMID:29668609

The success of opening single chronic total occlusion lesions to improve myocardialviabilitytrial (SOS-COMEDY): Study protocol of a prospective multicenter study.

PubMed

Huang, Rongchong; Song, Xiantao; Zhang, Haishan; Tian, Wen; Huang, Zheng; Zhang, Xingwei; Yang, Junqing; Zhang, Dongfeng; Wu, Jian; Zhong, Lei; Ting, Henry H

2018-04-01

Success of opening single (SOS)-comedy is a prospective multicenter study to compare the improvement in the decrease of myocardial viability by percutaneous coronary intervention (PCI) with that by optimal medical therapy (OMT) alone in patients with chronic total occlusion (CTO) of a single coronary artery. The risks and the benefits of both options (PCI and OMT) were listed in a CTO decision aid (DA). Eligible participants detected by invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) were divided into PCI or OMT groups according to patients' choice after shared-decision making process with DA. Participants will undergo positron emission tomography/computed tomography (PET/CT), cardiac magnetic resonance (CMR) and transthoracic echocardiography (TTE), and proceed to ICA and revascularization if possible. Blinded core laboratory interpretation will be performed for ICA, CCTA, PET/CT, CMR, and TTE. All participants will be followed up for 12 months. The primary endpoint is the improvement to the decrease of myocardial viability from baseline assessed with the use of PET/CT after 12-month follow-up. All of the patients are appropriately consented before enrolling in this study, which has been approved by the Ethics Committee. Results of SOS-COMEDY will be helpful to develop a strategy for single CTO patients.

Splitting a droplet for femtoliter liquid patterns and single cell isolation.

PubMed

Li, Huizeng; Yang, Qiang; Li, Guannan; Li, Mingzhu; Wang, Shutao; Song, Yanlin

2015-05-06

Well-defined microdroplet generation has attracted great interest, which is important for the high-resolution patterning and matrix distribution for chemical reactions and biological assays. By sliding a droplet on a patterned superhydrophilic/superhydrophobic substrate, tiny microdroplet arrays low to femtoliter were achieved with uniform volume and composition. Using this method, cells were successfully isolated, resulting in a single cell array. The droplet-splitting method is facile, sample-effective, and low-cost, which will be of great potential for the development of microdroplet arrays for biological analysis as well as patterning system and devices.

Infrared technology for satellite power conversion. [antenna arrays and bolometers

NASA Technical Reports Server (NTRS)

Campbell, D. P.; Gouker, M. A.; Gallagher, J. J.

1984-01-01

Successful fabrication of bismuth bolometers led to the observation of antenna action rom array elements. Fabrication of the best antennas arrays was made more facile with finding that increased argon flow during the dc sputtering produced more uniform bismuth films and bonding to antennas must be done with the substrate temperaure below 100 C. Higher temperatures damaged the bolometers. During the testing of the antennas, it was found that the use of a quasi-optical system provided a uniform radiation field. Groups of antennas were bonded in series and in parallel with the parallel configuration showing the greater response.

Highly efficient and completely flexible fiber-shaped dye-sensitized solar cell based on TiO2 nanotube array.

PubMed

Lv, Zhibin; Yu, Jiefeng; Wu, Hongwei; Shang, Jian; Wang, Dan; Hou, Shaocong; Fu, Yongping; Wu, Kai; Zou, Dechun

2012-02-21

A type of highly efficient completely flexible fiber-shaped solar cell based on TiO(2) nanotube array is successfully prepared. Under air mass 1.5G (100 mW cm(-2)) illumination conditions, the photoelectric conversion efficiency of the solar cell approaches 7%, the highest among all fiber-shaped cells based on TiO(2) nanotube arrays and the first completely flexible fiber-shaped DSSC. The fiber-shaped solar cell demonstrates good flexibility, which makes it suitable for modularization using weaving technologies. This journal is © The Royal Society of Chemistry 2012

International Space Station (ISS)

NASA Image and Video Library

2007-11-03

Astronaut Doug Wheelock, STS-120 mission specialist, participated in the mission's fourth session of extravehicular activity (EVA) while Space Shuttle Discovery was docked with the International Space Station (ISS). During the 7-hour and 19-minute space walk, astronaut Scott Parazynski (out of frame), mission specialist, cut a snagged wire and installed homemade stabilizers designed to strengthen the structure and stability of the damaged P6 4B solar array wing. Wheelock assisted from the truss by keeping an eye on the distance between Parazynski and the array. Once the repair was complete, flight controllers on the ground successfully completed the deployment of the array.

Design of current source for multi-frequency simultaneous electrical impedance tomography

NASA Astrophysics Data System (ADS)

Han, Bing; Xu, Yanbin; Dong, Feng

2017-09-01

Multi-frequency electrical impedance tomography has been evolving from the frequency-sweep approach to the multi-frequency simultaneous measurement technique which can reduce measuring time and will be increasingly attractive for time-varying biological applications. The accuracy and stability of the current source are the key factors determining the quality of the image reconstruction. This article presents a field programmable gate array-based current source for a multi-frequency simultaneous electrical impedance tomography system. A novel current source circuit was realized by combining the classic current mirror based on the feedback amplifier AD844 with a differential topology. The optimal phase offsets of harmonic sinusoids were obtained through the crest factor analysis. The output characteristics of this current source were evaluated by simulation and actual measurement. The results include the following: (1) the output impedance was compared with one of the Howland pump circuit in simulation, showing comparable performance at low frequencies. However, the proposed current source makes lower demands for resistor tolerance but performs even better at high frequencies. (2) The output impedance in actual measurement below 200 kHz is above 1.3 MΩ and can reach 250 KΩ up to 1 MHz. (3) An experiment based on a biological RC model has been implemented. The mean error for the demodulated impedance amplitude and phase are 0.192% and 0.139°, respectively. Therefore, the proposed current source is wideband, biocompatible, and high precision, which demonstrates great potential to work as a sub-system in the multi-frequency electrical impedance tomography system.

A New Omni-Directional EMAT for Ultrasonic Lamb Wave Tomography Imaging of Metallic Plate Defects

PubMed Central

Huang, Songling; Wei, Zheng; Zhao, Wei; Wang, Shen

2014-01-01

This paper proposes a new omni-directional electromagnetic acoustic transducer (EMAT) for the ultrasonic Lamb wave (ULW) tomography imaging (TI) of defects in metallic plates. The proposed EMAT is composed of a permanent magnet and a coil with a contra-flexure structure. This new EMAT coil structure is used for omni-directional ULW transmission and reception and ULW TI for the first time. The theoretical background and the working principles of this EMAT are presented and analyzed. The experimental results of its use on a 3 mm thick aluminum plate indicate that the EMAT with a contra-flexure coil (CFC) can transmit and receive a pure single A0 mode ULW with a high signal-to-noise ratio (SNR). Thus, the extraction of the projection data used for ULW TI may be performed accurately. The circumferential consistency of the projection data is only slightly influenced by the distortion of the eddy current field that is induced by the new CFC with an irregular shape. When the new EMAT array is used for ULW TI using the cross-hole method and SIRT arithmetic, a desirable imaging quality can be achieved, and the estimated size of an artificial corrosion defect agreed well with its actual value. The relation between the reconstruction resolution and the number of the new EMATs used is analyzed. More TI experiments are carried out when the aluminum plate defect is in two different locations relative to the EMAT array, for the further investigation of the performances of the new EMATs. PMID:24561398

Characterisation of ground motion recording stations in the Groningen gas field

NASA Astrophysics Data System (ADS)

Noorlandt, Rik; Kruiver, Pauline P.; de Kleine, Marco P. E.; Karaoulis, Marios; de Lange, Ger; Di Matteo, Antonio; von Ketelhodt, Julius; Ruigrok, Elmer; Edwards, Benjamin; Rodriguez-Marek, Adrian; Bommer, Julian J.; van Elk, Jan; Doornhof, Dirk

2018-05-01

The seismic hazard and risk analysis for the onshore Groningen gas field requires information about local soil properties, in particular shear-wave velocity ( V S). A fieldwork campaign was conducted at 18 surface accelerograph stations of the monitoring network. The subsurface in the region consists of unconsolidated sediments and is heterogeneous in composition and properties. A range of different methods was applied to acquire in situ V S values to a target depth of at least 30 m. The techniques include seismic cone penetration tests (SCPT) with varying source offsets, multichannel analysis of surface waves (MASW) on Rayleigh waves with different processing approaches, microtremor array, cross-hole tomography and suspension P-S logging. The offset SCPT, cross-hole tomography and common midpoint cross-correlation (CMPcc) processing of MASW data all revealed lateral variations on length scales of several to tens of metres in this geological setting. SCPTs resulted in very detailed V S profiles with depth, but represent point measurements in a heterogeneous environment. The MASW results represent V S information on a larger spatial scale and smooth some of the heterogeneity encountered at the sites. The combination of MASW and SCPT proved to be a powerful and cost-effective approach in determining representative V S profiles at the accelerograph station sites. The measured V S profiles correspond well with the modelled profiles and they significantly enhance the ground motion model derivation. The similarity between the theoretical transfer function from the V S profile and the observed amplification from vertical array stations is also excellent.

Travel-time Tomography of the Upper Mantle using Amphibious Array Seismic Data from the Cascadia Initiative and EarthScope

NASA Astrophysics Data System (ADS)

Cafferky, S.; Schmandt, B.

2013-12-01

Offshore and onshore broadband seismic data from the Cascadia Initiative and EarthScope provide a unique opportunity to image 3-D mantle structure continuously from a spreading ridge across a subduction zone and into continental back-arc provinces. Year one data from the Cascadia Initiative primarily covers the northern half of the Juan de Fuca plate and the Cascadia forearc and arc provinces. These new data are used in concert with previously collected onshore data for a travel-time tomography investigation of mantle structure. Measurement of relative teleseismic P travel times for land-based and ocean-bottom stations operating during year one was completed for 16 events using waveform cross-correlation, after bandpass filtering the data from 0.05 - 0.1 Hz with a second order Butterworth filter. Maps of travel-time delays show changing patterns with event azimuth suggesting that structural variations exist beneath the oceanic plate. The data from year one and prior onshore travel time measurements were used in a tomographic inversion for 3-D mantle P-velocity structure. Inversions conducted to date use ray paths determined by a 1-D velocity model. By meeting time we plan to present models using ray paths that are iteratively updated to account for 3-D structure. Additionally, we are testing the importance of corrections for sediment and crust thickness on imaging of mantle structure near the subduction zone. Low-velocities beneath the Juan de Fuca slab that were previously suggested by onshore data are further supported by our preliminary tomographic inversions using the amphibious array data.

Characterisation of ground motion recording stations in the Groningen gas field

NASA Astrophysics Data System (ADS)

Noorlandt, Rik; Kruiver, Pauline P.; de Kleine, Marco P. E.; Karaoulis, Marios; de Lange, Ger; Di Matteo, Antonio; von Ketelhodt, Julius; Ruigrok, Elmer; Edwards, Benjamin; Rodriguez-Marek, Adrian; Bommer, Julian J.; van Elk, Jan; Doornhof, Dirk

2018-01-01

The seismic hazard and risk analysis for the onshore Groningen gas field requires information about local soil properties, in particular shear-wave velocity (V S). A fieldwork campaign was conducted at 18 surface accelerograph stations of the monitoring network. The subsurface in the region consists of unconsolidated sediments and is heterogeneous in composition and properties. A range of different methods was applied to acquire in situ V S values to a target depth of at least 30 m. The techniques include seismic cone penetration tests (SCPT) with varying source offsets, multichannel analysis of surface waves (MASW) on Rayleigh waves with different processing approaches, microtremor array, cross-hole tomography and suspension P-S logging. The offset SCPT, cross-hole tomography and common midpoint cross-correlation (CMPcc) processing of MASW data all revealed lateral variations on length scales of several to tens of metres in this geological setting. SCPTs resulted in very detailed V S profiles with depth, but represent point measurements in a heterogeneous environment. The MASW results represent V S information on a larger spatial scale and smooth some of the heterogeneity encountered at the sites. The combination of MASW and SCPT proved to be a powerful and cost-effective approach in determining representative V S profiles at the accelerograph station sites. The measured V S profiles correspond well with the modelled profiles and they significantly enhance the ground motion model derivation. The similarity between the theoretical transfer function from the V S profile and the observed amplification from vertical array stations is also excellent.

Electron tomography and fractal aspects of MoS2 and MoS2/Co spheres.

PubMed

Ramos, Manuel; Galindo-Hernández, Félix; Arslan, Ilke; Sanders, Toby; Domínguez, José Manuel

2017-09-26

A study was made by a combination of 3D electron tomography reconstruction methods and N 2 adsorption for determining the fractal dimension for nanometric MoS 2 and MoS 2 /Co catalyst particles. DFT methods including Neimarke-Kiselev's method allowed to determine the particle porosity and fractal arrays at the atomic scale for the S-Mo-S(Co) 2D- layers that conform the spherically shaped catalyst particles. A structural and textural correlation was sought by further characterization performed by x-ray Rietveld refinement and Radial Distribution Function (RDF) methods, electron density maps, computational density functional theory methods and nitrogen adsorption methods altogether, for studying the structural and textural features of spherical MoS 2 and MoS 2 /Co particles. Neimark-Kiselev's equations afforded the evaluation of a pore volume variation from 10 to 110 cm 3 /g by cobalt insertion in the MoS 2 crystallographic lattice, which induces the formation of cavities and throats in between of less than 29 nm, with a curvature radius r k  < 14.4 nm; typical large needle-like arrays having 20 2D layers units correspond to a model consisting of smooth surfaces within these cavities. Decreasing D P , D B , D I and D M values occur when Co atoms are present in the MoS 2 laminates, which promote the formation of smoother edges and denser surfaces that have an influence on the catalytic properties of the S-Mo-S(Co) system.

The effect of receiver coil orientations on the imaging performance of magnetic induction tomography

NASA Astrophysics Data System (ADS)

Gürsoy, D.; Scharfetter, H.

2009-10-01

Magnetic induction tomography is an imaging modality which aims to reconstruct the conductivity distribution of the human body. It uses magnetic induction to excite the body and an array of sensor coils to detect the perturbations in the magnetic field. Up to now, much effort has been expended with the aim of finding an efficient coil configuration to extend the dynamic range of the measured signal. However, the merits of different sensor orientations on the imaging performance have not been studied in great detail so far. Therefore, the aim of the study is to fill the void of a systematic investigation of coil orientations on the reconstruction quality of the designs. To this end, a number of alternative receiver array designs with different coil orientations were suggested and the evaluations of the designs were performed based on the singular value decomposition. A generalized class of quality measures, the subclasses of which are linked to both the spatial resolution and uncertainty measures, was used to assess the performance on the radial and axial axes of a cylindrical phantom. The detectability of local conductivity perturbations in the phantom was explored using the reconstructed images. It is possible to draw the conclusion that the proper choice of the coil orientations significantly influences the number of usable singular vectors and accordingly the stability of image reconstruction, although the effect of increased stability on the quality of the reconstructed images was not of paramount importance due to the reduced independent information content of the associated singular vectors.

Linear-array-based photoacoustic tomography for label-free high-throughput detection and quantification of circulating melanoma tumor cell clusters

NASA Astrophysics Data System (ADS)

Hai, Pengfei; Zhou, Yong; Zhang, Ruiying; Ma, Jun; Li, Yang; Wang, Lihong V.

2017-03-01

Circulating tumor cell (CTC) clusters arise from multicellular grouping in the primary tumor and elevate the metastatic potential by 23 to 50 fold compared to single CTCs. High throughout detection and quantification of CTC clusters is critical for understanding the tumor metastasis process and improving cancer therapy. In this work, we report a linear-array-based photoacoustic tomography (LA-PAT) system capable of label-free high-throughput CTC cluster detection and quantification in vivo. LA-PAT detects CTC clusters and quantifies the number of cells in them based on the contrast-to-noise ratios (CNRs) of photoacoustic signals. The feasibility of LA-PAT was first demonstrated by imaging CTC clusters ex vivo. LA-PAT detected CTC clusters in the blood-filled microtubes and computed the number of cells in the clusters. The size distribution of the CTC clusters measured by LA-PAT agreed well with that obtained by optical microscopy. We demonstrated the ability of LA-PAT to detect and quantify CTC clusters in vivo by imaging injected CTC clusters in rat tail veins. LA-PAT detected CTC clusters immediately after injection as well as when they were circulating in the rat bloodstreams. Similarly, the numbers of cells in the clusters were computed based on the CNRs of the photoacoustic signals. The data showed that larger CTC clusters disappear faster than the smaller ones. The results prove the potential of LA-PAT as a promising tool for both preclinical tumor metastasis studies and clinical cancer therapy evaluation.

The Stretched Lens Array (SLA): An Ultra-Light Photovoltaic Concentrator

NASA Technical Reports Server (NTRS)

ONeill, Mark J.; Pisczor, Michael F.; Eskenazi, Michael I.; McDanal, A. J.; George, Patrick J.; Botke, Matthew M.; Brandhorst, Henry W.; Edwards, David L.; Jaster, Paul A.

2002-01-01

A high-performance, ultralight, photovoltaic concentrator array is being developed for space power. The stretched lens array (SLA) uses stretched-membrane, silicone Fresnel lenses to concentrate sunlight onto triple-junction photovoltaic cells. The cells are mounted to a composite radiator structure. The entire solar array wing, including lenses, photovoltaic cell flex circuits, composite panels, hinges, yoke, wiring harness, and deployment mechanisms, has a mass density of 1.6 kg/sq.m. NASA Glenn has measured 27.4% net SLA panel efficiency, or 375 W/sq.m. power density, at room temperature. At GEO operating cell temperature (80 C), this power density will be 300 W/sq.m., resulting in more than 180 W/kg specific power at the full wing level. SLA is a direct ultralight descendent of the successful SCARLET array on NASA's Deep Space 1 spacecraft. This paper describes the evolution from SCARLET to SLA, summarizes the SLA's key features, and provides performance and mass data for this new concentrator array.

Methods of Real Time Image Enhancement of Flash LIDAR Data and Navigating a Vehicle Using Flash LIDAR Data

NASA Technical Reports Server (NTRS)

Vanek, Michael D. (Inventor)

2014-01-01

A method for creating a digital elevation map ("DEM") from frames of flash LIDAR data includes generating a first distance R(sub i) from a first detector i to a first point on a surface S(sub i). After defining a map with a mesh THETA having cells k, a first array S(k), a second array M(k), and a third array D(k) are initialized. The first array corresponds to the surface, the second array corresponds to the elevation map, and the third array D(k) receives an output for the DEM. The surface is projected onto the mesh THETA, so that a second distance R(sub k) from a second point on the mesh THETA to the detector can be found. From this, a height may be calculated, which permits the generation of a digital elevation map. Also, using sequential frames of flash LIDAR data, vehicle control is possible using an offset between successive frames.

Method for Enhancing a Three Dimensional Image from a Plurality of Frames of Flash LIDAR Data

NASA Technical Reports Server (NTRS)

Bulyshev, Alexander (Inventor); Vanek, Michael D. (Inventor); Amzajerdian, Farzin (Inventor)

2013-01-01

A method for enhancing a three dimensional image from frames of flash LIDAR data includes generating a first distance R(sub i) from a first detector i to a first point on a surface S(sub i). After defining a map with a mesh theta having cells k, a first array S(k), a second array M(k), and a third array D(k) are initialized. The first array corresponds to the surface, the second array corresponds to the elevation map, and the third array D(k) receives an output for the DEM. The surface is projected onto the mesh theta, so that a second distance R(sub k) from a second point on the mesh theta to the detector can be found. From this, a height may be calculated, which permits the generation of a digital elevation map. Also, using sequential frames of flash LIDAR data, vehicle control is possible using an offset between successive frames.

Large-area high-power VCSEL pump arrays optimized for high-energy lasers

NASA Astrophysics Data System (ADS)

Wang, Chad; Geske, Jonathan; Garrett, Henry; Cardellino, Terri; Talantov, Fedor; Berdin, Glen; Millenheft, David; Renner, Daniel; Klemer, Daniel

2012-06-01

Practical, large-area, high-power diode pumps for one micron (Nd, Yb) as well as eye-safer wavelengths (Er, Tm, Ho) are critical to the success of any high energy diode pumped solid state laser. Diode efficiency, brightness, availability and cost will determine how realizable a fielded high energy diode pumped solid state laser will be. 2-D Vertical-Cavity Surface-Emitting Laser (VCSEL) arrays are uniquely positioned to meet these requirements because of their unique properties, such as low divergence circular output beams, reduced wavelength drift with temperature, scalability to large 2-D arrays through low-cost and high-volume semiconductor photolithographic processes, high reliability, no catastrophic optical damage failure, and radiation and vacuum operation tolerance. Data will be presented on the status of FLIR-EOC's VCSEL pump arrays. Analysis of the key aspects of electrical, thermal and mechanical design that are critical to the design of a VCSEL pump array to achieve high power efficient array performance will be presented.

Shear wave velocities in the upper mantle of the Western Alps: new constraints using array analysis of seismic surface waves

NASA Astrophysics Data System (ADS)

Lyu, Chao; Pedersen, Helle A.; Paul, Anne; Zhao, Liang; Solarino, Stefano

2017-07-01

It remains challenging to obtain absolute shear wave velocities of heterogeneities of small lateral extension in the uppermost mantle. This study presents a cross-section of Vs across the strongly heterogeneous 3-D structure of the western European Alps, based on array analysis of data from 92 broad-band seismic stations from the CIFALPS experiment and from permanent networks in France and Italy. Half of the stations were located along a dense sublinear array. Using a combination of these stations and off-profile stations, fundamental-mode Rayleigh wave dispersion curves were calculated using a combined frequency-time beamforming approach. We calculated dispersion curves for seven arrays of approximately 100 km aperture and 14 arrays of approximately 50 km aperture, the latter with the aim of obtaining a 2-D vertical cross-section of Vs beneath the western Alps. The dispersion curves were inverted for Vs(z), with crustal interfaces imposed from a previous receiver function study. The array approach proved feasible, as Vs(z) from independent arrays vary smoothly across the profile length. Results from the seven large arrays show that the shear velocity of the upper mantle beneath the European plate is overall low compared to AK135 with the lowest velocities in the internal part of the western Alps, and higher velocities east of the Alps beneath the Po plain. The 2-D Vs model is coherent with (i) a ∼100 km thick eastward-dipping European lithosphere west of the Alps, (ii) very high velocities beneath the Po plain, coherent with the presence of the Alpine (European) slab and (iii) a narrow low-velocity anomaly beneath the core of the western Alps (from the Briançonnais to the Dora Maira massif), and approximately colocated with a similar anomaly observed in a recent teleseismic P-wave tomography. This intriguing anomaly is also supported by traveltime variations of subvertically propagating body waves from two teleseismic events that are approximately located on the profile great circle.

Shape calibration of a conformal ultrasound therapy array.

PubMed

McGough, R J; Cindric, D; Samulski, T V

2001-03-01

A conformal ultrasound phased array prototype with 96 elements was recently calibrated for electronic steering and focusing in a water tank. The procedure for calibrating the shape of this 2D therapy array consists of two steps. First, a least squares triangulation algorithm determines the element coordinates from a 21 x 21 grid of time delays. The triangulation algorithm also requires temperature measurements to compensate for variations in the speed of sound. Second, a Rayleigh-Sommerfeld formulation of the acoustic radiation integral is aligned to a second grid of measured pressure amplitudes in a least squares sense. This shape calibration procedure, which is applicable to a wide variety of ultrasound phased arrays, was tested on a square array panel consisting of 7- x 7-mm elements operating at 617 kHz. The simulated fields generated by an array of 96 equivalent elements are consistent with the measured data, even in the fine structure away from the primary focus and sidelobes. These two calibration steps are sufficient for the simulation model to predict successfully the pressure field generated by this conformal ultrasound phased array prototype.

Characterization of the dental pulp using optical coherence tomography

NASA Astrophysics Data System (ADS)

Kauffman, C. M. F.; Carvalho, M. T.; Araujo, R. E.; Freitas, A. Z.; Zezell, D. M.; Gomes, A. S. L.

2006-02-01

The inner structure of teeth, i.e. the root canal anatomy, is very complex. However a good knowledge of endodontic architecture is the first step towards successful endodontic treatment. Optical coherence tomography (OCT) is a powerful technique to generate images of hard and soft tissue. Its images show dependency on the optical properties of the tissue under analysis. Changes in the scattering and absorption of tissues can be observed through the OCT images. In this work, we used optical coherence tomography to perform in vitro studies of the inner structure of the first molar of albino rats (Rattus norvegicus). Focusing on the pulp chamber and in the root canal, we compare the images generated with the OCT technique to the histology. We are analyzing the feasibility of OCT to help on the diagnostic of endodontic diseases.

Tectonic Inversion Along the Algerian and Ligurian Margins: On the Insight Provided By Latest Seismic Processing Techniques Applied to Recent and Vintage 2D Offshore Multichannel Seismic Data

NASA Astrophysics Data System (ADS)

Schenini, L.; Beslier, M. O.; Sage, F.; Badji, R.; Galibert, P. Y.; Lepretre, A.; Dessa, J. X.; Aidi, C.; Watremez, L.

2014-12-01

Recent studies on the Algerian and the North-Ligurian margins in the Western Mediterranean have evidenced inversion-related superficial structures, such as folds and asymmetric sedimentary perched basins whose geometry hints at deep compressive structures dipping towards the continent. Deep seismic imaging of these margins is difficult due to steep slope and superficial multiples, and, in the Mediterranean context, to the highly diffractive Messinian evaporitic series in the basin. During the Algerian-French SPIRAL survey (2009, R/V Atalante), 2D marine multi-channel seismic (MCS) reflection data were collected along the Algerian Margin using a 4.5 km, 360 channel digital streamer and a 3040 cu. in. air-gun array. An advanced processing workflow has been laid out using Geocluster CGG software, which includes noise attenuation, 2D SRME multiple attenuation, surface consistent deconvolution, Kirchhoff pre-stack time migration. This processing produces satisfactory seismic images of the whole sedimentary cover, and of southward dipping reflectors in the acoustic basement along the central part of the margin offshore Great Kabylia, that are interpreted as inversion-related blind thrusts as part of flat-ramp systems. We applied this successful processing workflow to old 2D marine MCS data acquired on the North-Ligurian Margin (Malis survey, 1995, R/V Le Nadir), using a 2.5 km, 96 channel streamer and a 1140 cu. in. air-gun array. Particular attention was paid to multiple attenuation in adapting our workflow. The resulting reprocessed seismic images, interpreted with a coincident velocity model obtained by wide-angle data tomography, provide (1) enhanced imaging of the sedimentary cover down to the top of the acoustic basement, including the base of the Messinian evaporites and the sub-salt Miocene series, which appear to be tectonized as far as in the mid-basin, and (2) new evidence of deep crustal structures in the margin which the initial processing had failed to reveal.

Design a New Strategy Based on Nanoparticle-Enhanced Chemiluminescence Sensor Array for Biothiols Discrimination

NASA Astrophysics Data System (ADS)

Shahrajabian, Maryam; Hormozi-Nezhad, M. Reza

2016-08-01

Array-based sensor is an interesting approach that suggests an alternative to expensive analytical methods. In this work, we introduce a novel, simple, and sensitive nanoparticle-based chemiluminescence (CL) sensor array for discrimination of biothiols (e.g., cysteine, glutathione and glutathione disulfide). The proposed CL sensor array is based on the CL efficiencies of four types of enhanced nanoparticle-based CL systems. The intensity of CL was altered to varying degrees upon interaction with biothiols, producing unique CL response patterns. These distinct CL response patterns were collected as “fingerprints” and were then identified through chemometric methods, including linear discriminant analysis (LDA) and hierarchical cluster analysis (HCA). The developed array was able to successfully differentiate between cysteine, glutathione and glutathione disulfide in a wide concentration range. Moreover, it was applied to distinguish among the above analytes in human plasma.

Stretched Lens Array Photovoltaic Concentrator Technology Developed

NASA Technical Reports Server (NTRS)

Piszczor, Michael F., Jr.; O'Neill, Mark J.

2004-01-01

Solar arrays have been and continue to be the mainstay in providing power to nearly all commercial and government spacecraft. Light from the Sun is directly converted into electrical energy using solar cells. One way to reduce the cost of future space power systems is by minimizing the size and number of expensive solar cells by focusing the sunlight onto smaller cells using concentrator optics. The stretched lens array (SLA) is a unique concept that uses arched Fresnel lens concentrators to focus sunlight onto a line of high-efficiency solar cells located directly beneath. The SLA concept is based on the Solar Concentrator Array with Refractive Linear Element Technology (SCARLET) design that was used on NASA's New Millennium Deep Space 1 mission. The highly successful asteroid/comet rendezvous mission (1998 to 2001) demonstrated the performance and long-term durability of the SCARLET/SLA solar array design and set the foundation for further improvements to optimize its performance.

Performance of ethanol electro-oxidation on Ni-Cu alloy nanowires through composition modulation.

PubMed

Tian, Xi-Ke; Zhao, Xiao-Yu; Zhang, Li-de; Yang, Chao; Pi, Zhen-Bang; Zhang, Su-Xin

2008-05-28

To reduce the cost of the catalyst for direct ethanol fuel cells and improve its catalytic activity, highly ordered Ni-Cu alloy nanowire arrays have been fabricated successfully by differential pulse current electro-deposition into the pores of a porous anodic alumina membrane (AAMs). The energy dispersion spectrum, scanning and transmission electron microscopy were utilized to characterize the composition and morphology of the Ni-Cu alloy nanowire arrays. The results reveal that the nanowires in the array are uniform, well isolated and parallel to each other. The catalytic activity of the nanowire electrode arrays for ethanol oxidation was tested and the binary alloy nanowire array possesses good catalytic activity for the electro-oxidation of ethanol. The performance of ethanol electro-oxidation was controlled by varying the Cu content in the Ni-Cu alloy and the Ni-Cu alloy nanowire electrode shows much better stability than the pure Ni one.

Boeing's High Voltage Solar Tile Test Results

NASA Astrophysics Data System (ADS)

Reed, Brian J.; Harden, David E.; Ferguson, Dale C.; Snyder, David B.

2002-10-01

Real concerns of spacecraft charging and experience with solar array augmented electrostatic discharge arcs on spacecraft have minimized the use of high voltages on large solar arrays despite numerous vehicle system mass and efficiency advantages. Boeing's solar tile (patent pending) allows high voltage to be generated at the array without the mass and efficiency losses of electronic conversion. Direct drive electric propulsion and higher power payloads (lower spacecraft weight) will benefit from this design. As future power demand grows, spacecraft designers must use higher voltage to minimize transmission loss and power cable mass for very large area arrays. This paper will describe the design and discuss the successful test of Boeing's 500-Volt Solar Tile in NASA Glenn's Tenney chamber in the Space Plasma Interaction Facility. The work was sponsored by NASA's Space Solar Power Exploratory Research and Technology (SERT) Program and will result in updated high voltage solar array design guidelines being published.

Halbach array motor/generators: A novel generalized electric machine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merritt, B.T.; Post, R.F.; Dreifuerst, G.R.

1995-02-01

For many years Klaus Halbach has been investigating novel designs for permanent magnet arrays, using advanced analytical approaches and employing a keen insight into such systems. One of his motivations for this research was to find more efficient means for the utilization of permanent magnets for use in particle accelerators and in the control of particle beams. As a result of his pioneering work, high power free-electron laser systems, such as the ones built at the Lawrence Livermore Laboratory, became feasible, and his arrays have been incorporated into other particle-focusing systems of various types. This paper reports another, quite different,more » application of Klaus` work, in the design of high power, high efficiency, electric generators and motors. When tested, these motor/generator systems display some rather remarkable properties. Their success derives from the special properties which these arrays, which the authors choose to call {open_quotes}Halbach arrays,{close_quotes} possess.« less

Boeing's High Voltage Solar Tile Test Results

NASA Technical Reports Server (NTRS)

Reed, Brian J.; Harden, David E.; Ferguson, Dale C.; Snyder, David B.

2002-01-01

Real concerns of spacecraft charging and experience with solar array augmented electrostatic discharge arcs on spacecraft have minimized the use of high voltages on large solar arrays despite numerous vehicle system mass and efficiency advantages. Boeing's solar tile (patent pending) allows high voltage to be generated at the array without the mass and efficiency losses of electronic conversion. Direct drive electric propulsion and higher power payloads (lower spacecraft weight) will benefit from this design. As future power demand grows, spacecraft designers must use higher voltage to minimize transmission loss and power cable mass for very large area arrays. This paper will describe the design and discuss the successful test of Boeing's 500-Volt Solar Tile in NASA Glenn's Tenney chamber in the Space Plasma Interaction Facility. The work was sponsored by NASA's Space Solar Power Exploratory Research and Technology (SERT) Program and will result in updated high voltage solar array design guidelines being published.

Readiness for School Involves an Array of Skills: Let's Not Forget Fine Motor Development. NCRECE In Focus. Volume 1, Issue 5

ERIC Educational Resources Information Center

Goffin, Stacie G.

2010-01-01

Interest in children's success as readers has existed for a long time. With growing attention to our nation's global competitiveness, school success with math and science is joining reading as important topic areas for children's early learning. As a result, new research is exploring predictors of school success with math and science as well as…

Preoperative (3-dimensional) computed tomography lung reconstruction before anatomic segmentectomy or lobectomy for stage I non-small cell lung cancer.

PubMed

Chan, Ernest G; Landreneau, James R; Schuchert, Matthew J; Odell, David D; Gu, Suicheng; Pu, Jiantao; Luketich, James D; Landreneau, Rodney J

2015-09-01

Accurate cancer localization and negative resection margins are necessary for successful segmentectomy. In this study, we evaluate a newly developed software package that permits automated segmentation of the pulmonary parenchyma, allowing 3-dimensional assessment of tumor size, location, and estimates of surgical margins. A pilot study using a newly developed 3-dimensional computed tomography analytic software package was performed to retrospectively evaluate preoperative computed tomography images of patients who underwent segmentectomy (n = 36) or lobectomy (n = 15) for stage 1 non-small cell lung cancer. The software accomplishes an automated reconstruction of anatomic pulmonary segments of the lung based on bronchial arborization. Estimates of anticipated surgical margins and pulmonary segmental volume were made on the basis of 3-dimensional reconstruction. Autosegmentation was achieved in 72.7% (32/44) of preoperative computed tomography images with slice thicknesses of 3 mm or less. Reasons for segmentation failure included local severe emphysema or pneumonitis, and lower computed tomography resolution. Tumor segmental localization was achieved in all autosegmented studies. The 3-dimensional computed tomography analysis provided a positive predictive value of 87% in predicting a marginal clearance greater than 1 cm and a 75% positive predictive value in predicting a margin to tumor diameter ratio greater than 1 in relation to the surgical pathology assessment. This preoperative 3-dimensional computed tomography analysis of segmental anatomy can confirm the tumor location within an anatomic segment and aid in predicting surgical margins. This 3-dimensional computed tomography information may assist in the preoperative assessment regarding the suitability of segmentectomy for peripheral lung cancers. Published by Elsevier Inc.

Role of post-mapping computed tomography in virtual-assisted lung mapping.

PubMed

Sato, Masaaki; Nagayama, Kazuhiro; Kuwano, Hideki; Nitadori, Jun-Ichi; Anraku, Masaki; Nakajima, Jun

2017-02-01

Background Virtual-assisted lung mapping is a novel bronchoscopic preoperative lung marking technique in which virtual bronchoscopy is used to predict the locations of multiple dye markings. Post-mapping computed tomography is performed to confirm the locations of the actual markings. This study aimed to examine the accuracy of marking locations predicted by virtual bronchoscopy and elucidate the role of post-mapping computed tomography. Methods Automated and manual virtual bronchoscopy was used to predict marking locations. After bronchoscopic dye marking under local anesthesia, computed tomography was performed to confirm the actual marking locations before surgery. Discrepancies between marking locations predicted by the different methods and the actual markings were examined on computed tomography images. Forty-three markings in 11 patients were analyzed. Results The average difference between the predicted and actual marking locations was 30 mm. There was no significant difference between the latest version of the automated virtual bronchoscopy system (30.7 ± 17.2 mm) and manual virtual bronchoscopy (29.8 ± 19.1 mm). The difference was significantly greater in the upper vs. lower lobes (37.1 ± 20.1 vs. 23.0 ± 6.8 mm, for automated virtual bronchoscopy; p < 0.01). Despite this discrepancy, all targeted lesions were successfully resected using 3-dimensional image guidance based on post-mapping computed tomography reflecting the actual marking locations. Conclusions Markings predicted by virtual bronchoscopy were dislocated from the actual markings by an average of 3 cm. However, surgery was accurately performed using post-mapping computed tomography guidance, demonstrating the indispensable role of post-mapping computed tomography in virtual-assisted lung mapping.

Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials.

PubMed

Myllymaa, Sami; Myllymaa, Katja; Korhonen, Hannu; Töyräs, Juha; Jääskeläinen, Juha E; Djupsund, Kaj; Tanila, Heikki; Lappalainen, Reijo

2009-06-15

Modern microfabrication techniques make it possible to develop microelectrode arrays that may be utilized not only in neurophysiological research but also in the clinic, e.g. in neurosurgery and as elements of neural prostheses. The aim of this study was to test whether a flexible microelectrode array is suitable for recording cortical surface field potentials in rats. Polyimide-based microelectrode arrays were fabricated by utilizing microfabrication techniques e.g. photolithography and magnetron sputter deposition. The present microelectrode array consists of eight platinum microelectrodes (round-shaped, Ø: 200 microm), transmission lines and connector pads sandwiched between two thin layers of biocompatible polyimide. The microelectrode arrays were electrochemically characterized by impedance spectroscopy in physiological saline solution and successfully tested in vivo by conducting acute and chronic measurements of evoked potentials on the surface of rat cortex. The arrays proved excellent flexibility and mechanical strength during handling and implantation onto the surface of cortex. The excellent electrochemical characteristics and stable in vivo recordings with high spatiotemporal resolution highlight the potential of these arrays. The fabrication protocol described here allows implementation of several other neural interfaces with different layouts, material selections or target areas either for recording or stimulation purposes.

Integration of Antibody Array Technology into Drug Discovery and Development.

PubMed

Huang, Wei; Whittaker, Kelly; Zhang, Huihua; Wu, Jian; Zhu, Si-Wei; Huang, Ruo-Pan

Antibody arrays represent a high-throughput technique that enables the parallel detection of multiple proteins with minimal sample volume requirements. In recent years, antibody arrays have been widely used to identify new biomarkers for disease diagnosis or prognosis. Moreover, many academic research laboratories and commercial biotechnology companies are starting to apply antibody arrays in the field of drug discovery. In this review, some technical aspects of antibody array development and the various platforms currently available will be addressed; however, the main focus will be on the discussion of antibody array technologies and their applications in drug discovery. Aspects of the drug discovery process, including target identification, mechanisms of drug resistance, molecular mechanisms of drug action, drug side effects, and the application in clinical trials and in managing patient care, which have been investigated using antibody arrays in recent literature will be examined and the relevance of this technology in progressing this process will be discussed. Protein profiling with antibody array technology, in addition to other applications, has emerged as a successful, novel approach for drug discovery because of the well-known importance of proteins in cell events and disease development.

SU-C-207-01: Four-Dimensional Inverse Geometry Computed Tomography: Concept and Its Validation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, K; Kim, D; Kim, T

2015-06-15

Purpose: In past few years, the inverse geometry computed tomography (IGCT) system has been developed to overcome shortcomings of a conventional computed tomography (CT) system such as scatter problem induced from large detector size and cone-beam artifact. In this study, we intend to present a concept of a four-dimensional (4D) IGCT system that has positive aspects above all with temporal resolution for dynamic studies and reduction of motion artifact. Methods: Contrary to conventional CT system, projection data at a certain angle in IGCT was a group of fractionated narrow cone-beam projection data, projection group (PG), acquired from multi-source array whichmore » have extremely short time gap of sequential operation between each of sources. At this, for 4D IGCT imaging, time-related data acquisition parameters were determined by combining multi-source scanning time for collecting one PG with conventional 4D CBCT data acquisition sequence. Over a gantry rotation, acquired PGs from multi-source array were tagged time and angle for 4D image reconstruction. Acquired PGs were sorted into 10 phase and image reconstructions were independently performed at each phase. Image reconstruction algorithm based upon filtered-backprojection was used in this study. Results: The 4D IGCT had uniform image without cone-beam artifact on the contrary to 4D CBCT image. In addition, the 4D IGCT images of each phase had no significant artifact induced from motion compared with 3D CT. Conclusion: The 4D IGCT image seems to give relatively accurate dynamic information of patient anatomy based on the results were more endurable than 3D CT about motion artifact. From this, it will be useful for dynamic study and respiratory-correlated radiation therapy. This work was supported by the Industrial R&D program of MOTIE/KEIT [10048997, Development of the core technology for integrated therapy devices based on real-time MRI guided tumor tracking] and the Mid-career Researcher Program (2014R1A2A1A10050270) through the National Research Foundation of Korea funded by the Ministry of Science, ICT&Future Planning.« less

Is the Isabella anomaly a fossil slab or the foundered lithospheric root of the Sierra Nevada batholith?

NASA Astrophysics Data System (ADS)

Hoots, C. R.; Schmandt, B.; Clayton, R. W.; Hansen, S. M.; Dougherty, S. L.

2015-12-01

The Isabella Anomaly is a volume of relatively high seismic velocity upper mantle beneath the southern Great Valley in California. We deployed ~45 broadband seismometers in central California to test two main hypotheses for the origin of the Isabella Anomaly. One suggests that the Isabella Anomaly is the foundered lithospheric root of the southern Sierra Nevada batholith, which delaminated on account of eclogite-rich composition and translated westward as it began to sink into the asthenosphere. The other hypothesis suggests that the Isabella Anomaly is a fossil slab fragment attached to the Monterey microplate that lies offshore of central California and thus it is mechanically coupled to the Pacific plate. Prior seismic imaging with ~70 km station spacing cannot resolve the landward termination of Monterey microplate lithosphere beneath coastal California or where/if the Isabella Anomaly is attached to North America lithosphere beneath the Great Valley. The new temporary broadband array consists of 40 broadband seismometers with ~7 km spacing extending from the central California coast to the western Sierra Nevada batholith, plus some outliers to fill gaps in the regional network coverage. The temporary array was initially deployed in early 2014 and will continue to record until October 2015 so the complete data are not yet available. Preliminary Ps scattered wave images show an abrupt ~6 km increase in Moho depth eastward across the San Andreas fault, a strong positive impedance contrast that dips westward from ~7-25 km beneath Great Valley, and a sharp Moho with a slight westward dip beneath the western edge of the Sierra Nevada batholith. Apparently low impedance contrast characterizes the Moho beneath the eastern Great Valley and foothills, consistent with near mantle velocities in the lower crust. Processing of the cumulative data that will be available in October 2015 and incorporation of new tomography models into scattered wave imaging are needed before assessing the significance of potential uppermost mantle interfaces that may represent edges of the Isabella Anomaly. Results from Ps and Sp scattered wave imaging, ambient noise surface wave tomography, teleseismic body-wave tomography, and teleseismic shear wave splitting will be presented.

Near surface structure of the North Anatolian Fault Zone near 30°E from Rayleigh and Love wave tomography using ambient seismic noise.

NASA Astrophysics Data System (ADS)

Taylor, G.; Rost, S.; Houseman, G. A.; Hillers, G.

2017-12-01

By utilising short period surface waves present in the noise field, we can construct images of shallow structure in the Earth's upper crust: a depth-range that is usually poorly resolved in earthquake tomography. Here, we use data from a dense seismic array (Dense Array for Northern Anatolia - DANA) deployed across the North Anatolian Fault Zone (NAFZ) in the source region of the 1999 magnitude 7.6 Izmit earthquake in western Turkey. The NAFZ is a major strike-slip system that extends 1200 km across northern Turkey and continues to pose a high level of seismic hazard, in particular to the mega-city of Istanbul. We obtain maps of group velocity variation using surface wave tomography applied to short period (1- 6 s) Rayleigh and Love waves to construct high-resolution images of SV and SH-wave velocity in the upper 5 km of a 70 km x 35 km region centred on the eastern end of the fault segment that ruptured in the 1999 Izmit earthquake. The average Rayleigh wave group velocities in the region vary between 1.8 km/s at 1.5 s period, to 2.2 km/s at 6 s period. The NAFZ bifurcates into northern and southern strands in this region; both are active but only the northern strand ruptured in the 1999 event. The signatures of both the northern and southern branches of the NAFZ are clearly associated with strong gradients in seismic velocity that also denote the boundaries of major tectonic units. This observation implies that the fault zone exploits the pre-existing structure of the Intra-Pontide suture zone. To the north of the NAFZ, we observe low S-wave velocities ( 2.0 km/s) associated with the unconsolidated sediments of the Adapazari basin, and blocks of weathered terrigenous clastic sediments. To the south of the northern branch of the NAFZ in the Armutlu block, we detect higher velocities ( 2.9 km/s) associated with a shallow crystalline basement, in particular a block of metamorphosed schists and marbles that bound the northern branch of the NAFZ.

Optimizing fixed observational assets in a coastal observatory

NASA Astrophysics Data System (ADS)

Frolov, Sergey; Baptista, António; Wilkin, Michael

2008-11-01

Proliferation of coastal observatories necessitates an objective approach to managing of observational assets. In this article, we used our experience in the coastal observatory for the Columbia River estuary and plume to identify and address common problems in managing of fixed observational assets, such as salinity, temperature, and water level sensors attached to pilings and moorings. Specifically, we addressed the following problems: assessing the quality of an existing array, adding stations to an existing array, removing stations from an existing array, validating an array design, and targeting of an array toward data assimilation or monitoring. Our analysis was based on a combination of methods from oceanographic and statistical literature, mainly on the statistical machinery of the best linear unbiased estimator. The key information required for our analysis was the covariance structure for a field of interest, which was computed from the output of assimilated and non-assimilated models of the Columbia River estuary and plume. The network optimization experiments in the Columbia River estuary and plume proved to be successful, largely withstanding the scrutiny of sensitivity and validation studies, and hence providing valuable insight into optimization and operation of the existing observational network. Our success in the Columbia River estuary and plume suggest that algorithms for optimal placement of sensors are reaching maturity and are likely to play a significant role in the design of emerging ocean observatories, such as the United State's ocean observation initiative (OOI) and integrated ocean observing system (IOOS) observatories, and smaller regional observatories.

Catheter-Malposition-Induced Cardiac Tamponade via Contrast Media Leakage During Computed Tomography Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liang, C.-D.; Ko, S.-F.; Huang, C.-F.

We present a rare case of a central venous catheter-malposition-induced life-threatening cardiac tamponade as a result of computed tomography (CT) with contrast enhancement in an infant with a ventricular septal defect and pulmonary atresia after a modified Blalock-Taussig shunt. The diagnosis was confirmed by chest radiographs and CT study with catheter perforation through the right atrial wall and extravasation of the contrast medium into the pericardium, leading to cardiac tamponade and subsequent circulatory collapse. Two hours after successful cardiopulmonary resuscitation, the patient gradually resumed normal hemodynamic status.

High-numerical-aperture-based virtual point detectors for photoacoustic tomography

NASA Astrophysics Data System (ADS)

Li, Changhui; Wang, Lihong V.

2008-07-01

The focal point of a high-numerical-aperture (NA) ultrasonic transducer can be used as a virtual point detector. This virtual point detector detects omnidirectionally over a wide acceptance angle. It also combines a large active transducer surface and a small effective virtual detector size. Thus the sensitivity is high compared with that of a real point detector, and the aperture effect is small compared with that of a finite size transducer. We present two kinds of high-NA-based virtual point detectors and their successful application in photoacoustic tomography. They can also be applied in other ultrasound-related fields.

Radial reflection diffraction tomography

DOEpatents

Lehman, Sean K.

2012-12-18

A wave-based tomographic imaging method and apparatus based upon one or more rotating radially outward oriented transmitting and receiving elements have been developed for non-destructive evaluation. At successive angular locations at a fixed radius, a predetermined transmitting element can launch a primary field and one or more predetermined receiving elements can collect the backscattered field in a "pitch/catch" operation. A Hilbert space inverse wave (HSIW) algorithm can construct images of the received scattered energy waves using operating modes chosen for a particular application. Applications include, improved intravascular imaging, bore hole tomography, and non-destructive evaluation (NDE) of parts having existing access holes.

Noninvasively measuring oxygen saturation of human finger-joint vessels by multi-transducer functional photoacoustic tomography

NASA Astrophysics Data System (ADS)

Deng, Zijian; Li, Changhui

2016-06-01

Imaging small blood vessels and measuring their functional information in finger joint are still challenges for clinical imaging modalities. In this study, we developed a multi-transducer functional photoacoustic tomography (PAT) system and successfully imaged human finger-joint vessels from ˜1 mm to <0.2 mm in diameter. In addition, the oxygen saturation (SO2) values of these vessels were also measured. Our results demonstrate that PAT can provide both anatomical and functional information of individual finger-joint vessels with different sizes, which might help the study of finger-joint diseases, such as rheumatoid arthritis.

Drug delivery monitoring by photoacoustic tomography with an ICG encapsulated double emulsion

NASA Astrophysics Data System (ADS)

Wang, Xueding; Rajian, Justin R.; Fabiilli, Mario L.; Fowlkes, J. Brian; Carson, Paul L.

2012-02-01

We successfully encapsulated ICG in an ultrasound-triggerable perfluorocarbon double emulsion that prevents ICG from binding with plasma proteins. Photoacoustic spectral measurements on point target as well as 2-D photoacoustic images of blood vessels revealed that the photoacoustic spectrum changes significantly in blood when the ICG-loaded emulsion undergoes acoustic droplet vaporization (ADV), which is the conversion of liquid droplets into gas bubbles using ultrasound. Other than providing a new photoacoustic contrast agent, the ICG encapsulated double emulsion, when imaged with photoacoustic tomography, could facilitate spatial and quantitative monitoring of ultrasound initiated drug delivery.

[A case of malignant lymphoma successfully diagnosed using Sasada transbronchial angled biopsy forceps].

PubMed

Komori, Chika; Sasada, Shinji; Okamoto, Norio; Kawahara, Kunimitsu; Uehara, Nobuko; Shimada, Kazutaka; Kuhara, Hanako; Terada, Haruko; Tsujino, Kazuyuki; Matsunashi, Tatsuro; Minami, Toshiyuki; Suzuki, Hidekazu; Kobayashi, Masashi; Hirashima, Tomonori; Matsui, Kaoru; Kawase, Ichiro; Kusunoki, Yoko

2009-01-01

A 68-year-old man was referred to our hospital due to general fatigue, fever and weight loss. His chest radiograph showed a nodule (2.8 cm) in the right middle lobe. Computed tomography and positron emission tomography showed multiple metastases to the bone, liver and lymph nodes. The lung nodule was not accessible by standard transbronchial forceps. However, biopsy specimens obtained using Sasada Transbronchial Angled Biopsy Forceps (STAF) pathologically confirmed the diagnosis of malignant lymphoma. We report the case, and discuss the utility of STAF for lung lesions that are difficult to access with standard forceps.

Monolithic Microwave Integrated Circuit (MMIC) Phased Array Demonstrated With ACTS

NASA Technical Reports Server (NTRS)

1996-01-01

Monolithic Microwave Integrated Circuit (MMIC) arrays developed by the NASA Lewis Research Center and the Air Force Rome Laboratory were demonstrated in aeronautical terminals and in mobile or fixed Earth terminals linked with NASA's Advanced Communications Technology Satellite (ACTS). Four K/Ka-band experimental arrays were demonstrated between May 1994 and May 1995. Each array had GaAs MMIC devices at each radiating element for electronic beam steering and distributed power amplification. The 30-GHz transmit array used in uplinks to ACTS was developed by Lewis and Texas Instruments. The three 20-GHz receive arrays used in downlinks from ACTS were developed in cooperation with the Air Force Rome Laboratory, taking advantage of existing Air Force integrated-circuit, active-phased-array development contracts with the Boeing Company and Lockheed Martin Corporation. Four demonstrations, each related to an application of high interest to both commercial and Department of Defense organizations, were conducted. The location, type of link, and the data rate achieved for each of the applications is shown. In one demonstration-- an aeronautical terminal experiment called AERO-X--a duplex voice link between an aeronautical terminal on the Lewis Learjet and ACTS was achieved. Two others demonstrated duplex voice links (and in one case, interactive video links as well) between ACTS and an Army high-mobility, multipurpose wheeled vehicle (HMMWV, or "humvee"). In the fourth demonstration, the array was on a fixed mount and was electronically steered toward ACTS. Lewis served as project manager for all demonstrations and as overall system integrator. Lewis engineers developed the array system including a controller for open-loop tracking of ACTS during flight and HMMWV motion, as well as a laptop data display and recording system used in all demonstrations. The Jet Propulsion Laboratory supported the AERO-X program, providing elements of the ACTS Mobile Terminal. The successful performance of experimental, proof-of-concept MMIC K/Ka-band arrays developed with U.S. industry in field demonstrations with ACTS indicates that high density MMIC integration at 20 and 30 GHz is indeed feasible. The successful development and demonstration of the MMIC array systems was possible only because of significant intergovernmental and Government/industry cooperation and the high level of teamwork within Lewis. The results provide a strong incentive for continuing the focused development of MMIC-array technology for satellite communications applications, with emphasis on packaging and cost issues, and for continuing the planning and conducting of other appropriate demonstrations or experiments of phased-array technology with ACTS. Given the present pressures on reducing funding for research and development in Government and industry, the extent to which this can be continued in a cooperative manner will determine whether MMIC array technology will make the transition from the proof-of-concept level to the operational system level.

Cell-Based Odorant Sensor Array for Odor Discrimination Based on Insect Odorant Receptors.

PubMed

Termtanasombat, Maneerat; Mitsuno, Hidefumi; Misawa, Nobuo; Yamahira, Shinya; Sakurai, Takeshi; Yamaguchi, Satoshi; Nagamune, Teruyuki; Kanzaki, Ryohei

2016-07-01

The olfactory system of living organisms can accurately discriminate numerous odors by recognizing the pattern of activation of several odorant receptors (ORs). Thus, development of an odorant sensor array based on multiple ORs presents the possibility of mimicking biological odor discrimination mechanisms. Recently, we developed novel odorant sensor elements with high sensitivity and selectivity based on insect OR-expressing Sf21 cells that respond to target odorants by displaying increased fluorescence intensity. Here we introduce the development of an odorant sensor array composed of several Sf21 cell lines expressing different ORs. In this study, an array pattern of four cell lines expressing Or13a, Or56a, BmOR1, and BmOR3 was successfully created using a patterned polydimethylsiloxane film template and cell-immobilizing reagents, termed biocompatible anchor for membrane (BAM). We demonstrated that BAM could create a clear pattern of Sf21 sensor cells without impacting their odorant-sensing performance. Our sensor array showed odorant-specific response patterns toward both odorant mixtures and single odorant stimuli, allowing us to visualize the presence of 1-octen-3-ol, geosmin, bombykol, and bombykal as an increased fluorescence intensity in the region of Or13a, Or56a, BmOR1, and BmOR3 cell lines, respectively. Therefore, we successfully developed a new methodology for creating a cell-based odorant sensor array that enables us to discriminate multiple target odorants. Our method might be expanded into the development of an odorant sensor capable of detecting a large range of environmental odorants that might become a promising tool used in various applications including the study of insect semiochemicals and food contamination.

Sub-200 ps CRT in monolithic scintillator PET detectors using digital SiPM arrays and maximum likelihood interaction time estimation.

PubMed

van Dam, Herman T; Borghi, Giacomo; Seifert, Stefan; Schaart, Dennis R

2013-05-21

Digital silicon photomultiplier (dSiPM) arrays have favorable characteristics for application in monolithic scintillator detectors for time-of-flight positron emission tomography (PET). To fully exploit these benefits, a maximum likelihood interaction time estimation (MLITE) method was developed to derive the time of interaction from the multiple time stamps obtained per scintillation event. MLITE was compared to several deterministic methods. Timing measurements were performed with monolithic scintillator detectors based on novel dSiPM arrays and LSO:Ce,0.2%Ca crystals of 16 × 16 × 10 mm(3), 16 × 16 × 20 mm(3), 24 × 24 × 10 mm(3), and 24 × 24 × 20 mm(3). The best coincidence resolving times (CRTs) for pairs of identical detectors were obtained with MLITE and measured 157 ps, 185 ps, 161 ps, and 184 ps full-width-at-half-maximum (FWHM), respectively. For comparison, a small reference detector, consisting of a 3 × 3 × 5 mm(3) LSO:Ce,0.2%Ca crystal coupled to a single pixel of a dSiPM array, was measured to have a CRT as low as 120 ps FWHM. The results of this work indicate that the influence of the optical transport of the scintillation photons on the timing performance of monolithic scintillator detectors can at least partially be corrected for by utilizing the information contained in the spatio-temporal distribution of the collection of time stamps registered per scintillation event.

Vertical comb-drive microscanner with 4x4 array of micromirrors for phase-shifting Mirau microinterferometry

NASA Astrophysics Data System (ADS)

Bargiel, Sylwester; Lullin, Justine; Lemoal, Patrice; Perrin, Stéphane; Passilly, Nicolas; Albero, Jorge; Froehly, Luc; Lardet-Vieudrin, Franck; Gorecki, Christophe

2016-04-01

In this paper, we present construction, fabrication and characterization of an electrostatic MOEMS vertical microscanner for generation of an optical phase shift in array-type interferometric microsystems. The microscanner employs asymmetric comb-drives for a vertical displacement of a large 4x4 array of reference micromirrors and for in-situ position sensing. The device is designed to be fully compatible with Mirau configuration and with vertical integration strategy. This enables further integration of the device within an "active" multi-channel Mirau micro-interferometer and implementation of the phase shifting interferometry (PSI) technique for imaging applications. The combination of micro-interferometer and PSI is particularly interesting in the swept-source optical coherence tomography, since it allows not only strong size reduction of a system but also improvement of its performance (sensitivity, removal of the image artefacts). The technology of device is based on double-side DRIE of SOI wafer and vapor HF releasing of the suspended platform. In the static mode, the device provides vertical displacement of micromirrors up to 2.8μm (0 - 40V), whereas at resonance (fo=500 Hz), it reaches 0.7 μm for only 1VDC+1VAC. In both operation modes, the measured displacement is much more than required for PSI implementation (352nm peak-to-peak). The presented device is a key component of array-type Mirau micro-interferometer that enables the construction of portable, low-cost interferometric systems, e.g. for in vivo medical diagnostics.

Sub-200 ps CRT in monolithic scintillator PET detectors using digital SiPM arrays and maximum likelihood interaction time estimation

NASA Astrophysics Data System (ADS)

van Dam, Herman T.; Borghi, Giacomo; Seifert, Stefan; Schaart, Dennis R.

2013-05-01

Digital silicon photomultiplier (dSiPM) arrays have favorable characteristics for application in monolithic scintillator detectors for time-of-flight positron emission tomography (PET). To fully exploit these benefits, a maximum likelihood interaction time estimation (MLITE) method was developed to derive the time of interaction from the multiple time stamps obtained per scintillation event. MLITE was compared to several deterministic methods. Timing measurements were performed with monolithic scintillator detectors based on novel dSiPM arrays and LSO:Ce,0.2%Ca crystals of 16 × 16 × 10 mm3, 16 × 16 × 20 mm3, 24 × 24 × 10 mm3, and 24 × 24 × 20 mm3. The best coincidence resolving times (CRTs) for pairs of identical detectors were obtained with MLITE and measured 157 ps, 185 ps, 161 ps, and 184 ps full-width-at-half-maximum (FWHM), respectively. For comparison, a small reference detector, consisting of a 3 × 3 × 5 mm3 LSO:Ce,0.2%Ca crystal coupled to a single pixel of a dSiPM array, was measured to have a CRT as low as 120 ps FWHM. The results of this work indicate that the influence of the optical transport of the scintillation photons on the timing performance of monolithic scintillator detectors can at least partially be corrected for by utilizing the information contained in the spatio-temporal distribution of the collection of time stamps registered per scintillation event.

Doctoral Success as Ongoing Quality Business: A Possible Conceptual Framework

ERIC Educational Resources Information Center

Bitzer, E. M.

2011-01-01

The challenges involving doctoral non-completion and a lack of academic or scholarly quality are not restricted to putting the blame on doctoral candidates themselves, their supervisors or the institutions where they enrol. As candidates carry huge responsibilities when entering doctoral studies, success can be associated with an array of factors…

A Phase Correction Technique Based on Spatial Movements of Antennas in Real-Time (S.M.A.R.T.) for Designing Self-Adapting Conformal Array Antennas

NASA Astrophysics Data System (ADS)

Roy, Sayan

This research presents a real-time adaptive phase correction technique for flexible phased array antennas on conformal surfaces of variable shapes. Previously reported pattern correctional methods for flexible phased array antennas require prior knowledge on the possible non-planar shapes in which the array may adapt for conformal applications. For the first time, this initial requirement of shape curvature knowledge is no longer needed and the instantaneous information on the relative location of array elements is used here for developing a geometrical model based on a set of Bezier curves. Specifically, by using an array of inclinometer sensors and an adaptive phase-correctional algorithm, it has been shown that the proposed geometrical model can successfully predict different conformal orientations of a 1-by-4 antenna array in real-time without the requirement of knowing the shape-changing characteristics of the surface the array is attached upon. Moreover, the phase correction technique is validated by determining the field patterns and broadside gain of the 1-by-4 antenna array on four different conformal surfaces with multiple points of curvatures. Throughout this work, measurements are shown to agree with the analytical solutions and full-wave simulations.

Vertical integration of array-type miniature interferometers at wafer level by using multistack anodic bonding

NASA Astrophysics Data System (ADS)

Wang, Wei-Shan; Wiemer, Maik; Froemel, Joerg; Enderlein, Tom; Gessner, Thomas; Lullin, Justine; Bargiel, Sylwester; Passilly, Nicolas; Albero, Jorge; Gorecki, Christophe

2016-04-01

In this work, vertical integration of miniaturized array-type Mirau interferometers at wafer level by using multi-stack anodic bonding is presented. Mirau interferometer is suitable for MEMS metrology and for medical imaging according to its vertical-, lateral- resolutions and working distances. Miniaturized Mirau interferometer can be a promising candidate as a key component of an optical coherence tomography (OCT) system. The miniaturized array-type interferometer consists of a microlens doublet, a Si-based MEMS Z scanner, a spacer for focus-adjustment and a beam splitter. Therefore, bonding technologies which are suitable for heterogeneous substrates are of high interest and necessary for the integration of MEMS/MOEMS devices. Multi-stack anodic bonding, which meets the optical and mechanical requirements of the MOEMS device, is adopted to integrate the array-type interferometers. First, the spacer and the beam splitter are bonded, followed by bonding of the MEMS Z scanner. In the meanwhile, two microlenses, which are composed of Si and glass wafers, are anodically bonded to form a microlens doublet. Then, the microlens doublet is aligned and bonded with the scanner/spacer/beam splitter stack. The bonded array-type interferometer is a 7- wafer stack and the thickness is approximately 5mm. To separate such a thick wafer stack with various substrates, 2-step laser cutting is used to dice the bonded stack into Mirau chips. To simplify fabrication process of each component, electrical connections are created at the last step by mounting a Mirau chip onto a flip chip PCB instead of through wafer vias. Stability of Au/Ti films on the MEMS Z scanner after anodic bonding, laser cutting and flip chip bonding are discussed as well.

Phase Velocity and Full-Waveform Analysis of Co-located Distributed Acoustic Sensing (DAS) Channels and Geophone Sensor

NASA Astrophysics Data System (ADS)

Parker, L.; Mellors, R. J.; Thurber, C. H.; Wang, H. F.; Zeng, X.

2015-12-01

A 762-meter Distributed Acoustic Sensing (DAS) array with a channel spacing of one meter was deployed at the Garner Valley Downhole Array in Southern California. The array was approximately rectangular with dimensions of 180 meters by 80 meters. The array also included two subdiagonals within the rectangle along which three-component geophones were co-located. Several active sources were deployed, including a 45-kN, swept-frequency, shear-mass shaker, which produced strong Rayleigh waves across the array. Both DAS and geophone traces were filtered in 2-Hz steps between 4 and 20 Hz to obtain phase velocities as a function of frequency from fitting the moveout of travel times over distances of 35 meters or longer. As an alternative to this traditional means of finding phase velocity, it is theoretically possible to find the Rayleigh-wave phase velocity at each point of co-location as the ratio of DAS and geophone responses, because DAS is sensitive to ground strain and geophones are sensitive to ground velocity, after suitable corrections for instrument response (Mikumo & Aki, 1964). The concept was tested in WPP, a seismic wave propagation program, by first validating and then using a 3D synthetic, full-waveform seismic model to simulate the effect of increased levels of noise and uncertainty as data go from ideal to more realistic. The results obtained from this study provide a better understanding of the DAS response and its potential for being combined with traditional seismometers for obtaining phase velocity at a single location. This analysis is part of the PoroTomo project (Poroelastic Tomography by Adjoint Inverse Modeling of Data from Seismology, Geodesy, and Hydrology, http://geoscience.wisc.edu/feigl/porotomo).

Tropospheric wet refractivity tomography using multiplicative algebraic reconstruction technique

NASA Astrophysics Data System (ADS)

Xiaoying, Wang; Ziqiang, Dai; Enhong, Zhang; Fuyang, K. E.; Yunchang, Cao; Lianchun, Song

2014-01-01

Algebraic reconstruction techniques (ART) have been successfully used to reconstruct the total electron content (TEC) of the ionosphere and in recent years be tentatively used in tropospheric wet refractivity and water vapor tomography in the ground-based GNSS technology. The previous research on ART used in tropospheric water vapor tomography focused on the convergence and relaxation parameters for various algebraic reconstruction techniques and rarely discussed the impact of Gaussian constraints and initial field on the iteration results. The existing accuracy evaluation parameters calculated from slant wet delay can only evaluate the resultant precision of the voxels penetrated by slant paths and cannot evaluate that of the voxels not penetrated by any slant path. The paper proposes two new statistical parameters Bias and RMS, calculated from wet refractivity of the total voxels, to improve the deficiencies of existing evaluation parameters and then discusses the effect of the Gaussian constraints and initial field on the convergence and tomography results in multiplicative algebraic reconstruction technique (MART) to reconstruct the 4D tropospheric wet refractivity field using simulation method.

Effect of a Starting Model on the Solution of a Travel Time Seismic Tomography Problem

NASA Astrophysics Data System (ADS)

Yanovskaya, T. B.; Medvedev, S. V.; Gobarenko, V. S.

2018-03-01

In the problems of three-dimensional (3D) travel time seismic tomography where the data are travel times of diving waves and the starting model is a system of plane layers where the velocity is a function of depth alone, the solution turns out to strongly depend on the selection of the starting model. This is due to the fact that in the different starting models, the rays between the same points can intersect different layers, which makes the tomography problem fundamentally nonlinear. This effect is demonstrated by the model example. Based on the same example, it is shown how the starting model should be selected to ensure a solution close to the true velocity distribution. The starting model (the average dependence of the seismic velocity on depth) should be determined by the method of successive iterations at each step of which the horizontal velocity variations in the layers are determined by solving the two-dimensional tomography problem. An example illustrating the application of this technique to the P-wave travel time data in the region of the Black Sea basin is presented.

OAO-3 end of mission power subsystem evaluation

NASA Technical Reports Server (NTRS)

Tasevoli, M.

1982-01-01

End of mission tests were performed on the OAO-3 power subsystem in three component areas: solar array, nickel-cadmium batteries and the On-Board Processor (OBP) power boost operation. Solar array evaluation consisted of analyzing array performance characteristics and comparing them to earlier flight data. Measured solar array degradation of 14.1 to 17.7% after 8 1/3 years is in good agreement with theortical radiation damage losses. Battery discharge characteristics were compared to results of laboratory life cycle tests performed on similar cells. Comparison of cell voltage profils reveals close correlation and confirms the validity of real time life cycle simulation. The successful operation of the system in the OBP/power boost regulation mode demonstrates the excellent life, reliability and greater system utilization of power subsystems using maximum power trackers.

Harmful Gas Recognition Exploiting a CTL Sensor Array

PubMed Central

Wang, Qihui; Xie, Lijun; Zhu, Bo; Zheng, Yao; Cao, Shihua

2013-01-01

In this paper, a novel cataluminescence (CTL)-based sensor array consisting of nine types of catalytic materials is developed for the recognition of several harmful gases, namely carbon monoxide, acetone, chloroform and toluene. First, the experimental setup is constructed by using sensing nanomaterials, a heating plate, a pneumatic pump, a gas flow meter, a digital temperature device, a camera and a BPCL Ultra Weak Chemiluminescence Analyzer. Then, unique CTL patterns for the four types of harmful gas are obtained from the sensor array. The harmful gases are successful recognized by the PCA method. The optimal conditions are also investigated. Finally, experimental results show high sensitivity, long-term stability and good linearity of the sensor array, which combined with simplicity, make our system a promising application in this field. PMID:24113681

An HDF5-based framework for the distribution and analysis of ultrasonic concrete data

NASA Astrophysics Data System (ADS)

Prince, Luke; Clayton, Dwight; Santos-Villalobos, Hector

2017-02-01

There are many commercial ultrasonic tomography devices (UTDs) available for use in nondestructive evaluation (NDE) of reinforced concrete structures. These devices emit, measure, and store ultrasonic signals typically in the 25 kHz to 5 MHz frequency range. UTDs are characterized by a composition of multiple transducers, also known as a transducer array or phased array. Often, UTDs data are in a proprietary format. Consequently, NDE research data is limited to those who have prior non-disclosure agreements or the appropriate licenses. Thus, there is a need for a proper universal data framework to exist such that proprietary file datasets for different concrete specimens can be converted, organized, and stored with relative metadata for individual or collaborative NDE research. Building upon the Hierarchical Data Format (HDF5) model, we have developed a UTD data management framework and Graphic User Interface (GUI) to promote the algorithmic reconstruction of ultrasonic data in a controlled environment for easily reproducible and publishable results.

An HDF5-Based Framework for the Distribution and Analysis of Ultrasonic Concrete Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prince, Luke J; Clayton, Dwight A; Santos-Villalobos, Hector J

There are many commercial ultrasonic tomography devices (UTDs) available for use in nondestructive evaluation (NDE) of reinforced concrete structures. These devices emit, measure, and store ultrasonic signals typically in the 25 kHz to 5 MHz frequency range. UTDs are characterized by a composition of multiple transducers, also known as a transducer array or phased array. Often, UTDs data are in a proprietary format. Consequently, NDE research data is limited to those who have prior non-disclosure agreements or the appropriate licenses. Thus, there is a need for a proper universal data framework to exist such that proprietary file datasets for differentmore » concrete specimens can be converted, organized, and stored with relative metadata for individual or collaborative NDE research. Building upon the Hierarchical Data Format (HDF5) model, we have developed a UTD data management framework and Graphic User Interface (GUI) to promote the algorithmic reconstruction of ultrasonic data in a controlled environment for easily reproducible and publishable results.« less

A refraction-corrected tomographic algorithm for immersion laser-ultrasonic imaging of solids with piecewise linear surface profile

NASA Astrophysics Data System (ADS)

Zarubin, V.; Bychkov, A.; Simonova, V.; Zhigarkov, V.; Karabutov, A.; Cherepetskaya, E.

2018-05-01

In this paper, a technique for reflection mode immersion 2D laser-ultrasound tomography of solid objects with piecewise linear 2D surface profiles is presented. Pulsed laser radiation was used for generation of short ultrasonic probe pulses, providing high spatial resolution. A piezofilm sensor array was used for detection of the waves reflected by the surface and internal inhomogeneities of the object. The original ultrasonic image reconstruction algorithm accounting for refraction of acoustic waves at the liquid-solid interface provided longitudinal resolution better than 100 μm in the polymethyl methacrylate sample object.

Hydraulic Tomography and High-Resolution Slug Testing to Determine Hydraulic Conductivity Distributions

DTIC Science & Technology

2011-02-01

19 HRST Techniques ………………………………..…….…………… 20 CPT Techniques ………………………………..…….………….…. 22 Vertical Sensor Array ...and to predict water flood performance (Pierce, 1977). Other pulse test examples include tidal, seismic , and oil field methods. The changes in...induced by seismic waves were presented by Cooper et al. (1965). The pressure head fluctuations controlling water levels are a result of the

Hydraulic Tomography and High-Resolution Slug Testing to Determine Hydraulic Conductivity Distributions - Year 3

DTIC Science & Technology

2007-12-01

28 Vertical Sensor Array ………………..……….…………………………….. 30 MOGs Spring and Summer 2007 ……………….………………………….. 32 New Wells Installed...performance (Pierce, 1977). Other pulse test examples include tidal, seismic and oil field methods. The changes in groundwater levels as a result of...inland through an aquifer are related to aquifer storativity and transmissivity. Solutions to water level fluctuations induced by seismic waves were

High resolution collimator system for X-ray detector

DOEpatents

Eberhard, Jeffrey W.; Cain, Dallas E.

1987-01-01

High resolution in an X-ray computerized tomography (CT) inspection system is achieved by using a collimator/detector combination to limit the beam width of the X-ray beam incident on a detector element to the desired resolution width. In a detector such as a high pressure Xenon detector array, a narrow tapered collimator is provided above a wide detector element. The collimator slits have any desired width, as small as a few mils at the top, the slit width is easily controlled, and they are fabricated on standard machines. The slit length determines the slice thickness of the CT image.