Exploiting Universality in Atoms with Large Scattering Lengths

DOE Office of Scientific and Technical Information (OSTI.GOV)

Braaten, Eric

2012-05-31

The focus of this research project was atoms with scattering lengths that are large compared to the range of their interactions and which therefore exhibit universal behavior at sufficiently low energies. Recent dramatic advances in cooling atoms and in manipulating their scattering lengths have made this phenomenon of practical importance for controlling ultracold atoms and molecules. This research project was aimed at developing a systematically improvable method for calculating few-body observables for atoms with large scattering lengths starting from the universal results as a first approximation. Significant progress towards this goal was made during the five years of the project.

Thermal evaluation of advanced solar dynamic heat receiver performance

NASA Technical Reports Server (NTRS)

Crane, Roger A.

1989-01-01

The thermal performance of a variety of concepts for thermal energy storage as applied to solar dynamic applications is discussed. It is recognized that designs providing large thermal gradients or large temperature swings during orbit are susceptible to early mechanical failure. Concepts incorporating heat pipe technology may encounter operational limitations over sufficiently large ranges. By reviewing the thermal performance of basic designs, the relative merits of the basic concepts are compared. In addition the effect of thermal enhancement and metal utilization as applied to each design provides a partial characterization of the performance improvements to be achieved by developing these technologies.

Anti-aliasing techniques in photon-counting depth imaging using GHz clock rates

NASA Astrophysics Data System (ADS)

Krichel, Nils J.; McCarthy, Aongus; Collins, Robert J.; Buller, Gerald S.

2010-04-01

Single-photon detection technologies in conjunction with low laser illumination powers allow for the eye-safe acquisition of time-of-flight range information on non-cooperative target surfaces. We previously presented a photon-counting depth imaging system designed for the rapid acquisition of three-dimensional target models by steering a single scanning pixel across the field angle of interest. To minimise the per-pixel dwelling times required to obtain sufficient photon statistics for accurate distance resolution, periodic illumination at multi- MHz repetition rates was applied. Modern time-correlated single-photon counting (TCSPC) hardware allowed for depth measurements with sub-mm precision. Resolving the absolute target range with a fast periodic signal is only possible at sufficiently short distances: if the round-trip time towards an object is extended beyond the timespan between two trigger pulses, the return signal cannot be assigned to an unambiguous range value. Whereas constructing a precise depth image based on relative results may still be possible, problems emerge for large or unknown pixel-by-pixel separations or in applications with a wide range of possible scene distances. We introduce a technique to avoid range ambiguity effects in time-of-flight depth imaging systems at high average pulse rates. A long pseudo-random bitstream is used to trigger the illuminating laser. A cyclic, fast-Fourier supported analysis algorithm is used to search for the pattern within return photon events. We demonstrate this approach at base clock rates of up to 2 GHz with varying pattern lengths, allowing for unambiguous distances of several kilometers. Scans at long stand-off distances and of scenes with large pixel-to-pixel range differences are presented. Numerical simulations are performed to investigate the relative merits of the technique.

BKT phase transition in a 2D system with long-range dipole-dipole interaction

NASA Astrophysics Data System (ADS)

Fedichev, P. O.; Men'shikov, L. I.

2012-01-01

We consider phase transitions in 2D XY-like systems with long-range dipole-dipole interactions and demonstrate that BKT-type phase transition always occurs separating the ordered (ferroelectric) and the disordered (paraelectric) phases. The low-temperature phase corresponds to a thermal state with bound vortex-antivortex pairs characterized by linear attraction at large distances. Using the Maier-Schwabl topological charge model, we show that bound vortex pairs polarize and screen the vortex-antivortex interaction, leaving only the logarithmic attraction at sufficiently large separations between the vortices. At higher temperatures the pairs dissociate and the phase transition similar to BKT occurs, though at a larger temperature than in a system without the dipole-dipole interaction.

Oxygen concentration dependence of silicon oxide dynamical properties

NASA Astrophysics Data System (ADS)

Yajima, Yuji; Shiraishi, Kenji; Endoh, Tetsuo; Kageshima, Hiroyuki

2018-06-01

To understand oxidation in three-dimensional silicon, dynamic characteristics of a SiO x system with various stoichiometries were investigated. The calculated results show that the self-diffusion coefficient increases as oxygen density decreases, and the increase is large when the temperature is low. It also shows that the self-diffusion coefficient saturates, when the number of removed oxygen atoms is sufficiently large. Then, approximate analytical equations are derived from the calculated results, and the previously reported expression is confirmed in the extremely low-SiO-density range.

Large-scale Organized Magnetic Fields in O, B and A Stars

NASA Astrophysics Data System (ADS)

Mathys, G.

2009-06-01

The status of our current knowledge of magnetic fields in stars of spectral types ranging from early F to O is reviewed. Fields with large-scale organised structure have now been detected and measured throughout this range. These fields are consistent with the oblique rotator model. In early F to late B stars, their occurrence is restricted to the subgroup of the Ap stars, which have the best studied fields among the early-type stars. Presence of fields with more complex topologies in other A and late B stars has been suggested, but is not firmly established. Magnetic fields have not been studied in a sufficient number of OB stars yet so as to establish whether they occur in all or only in some subset of these stars.

DNA nanomechanics allows direct digital detection of complementary DNA and microRNA targets.

PubMed

Husale, Sudhir; Persson, Henrik H J; Sahin, Ozgur

2009-12-24

Techniques to detect and quantify DNA and RNA molecules in biological samples have had a central role in genomics research. Over the past decade, several techniques have been developed to improve detection performance and reduce the cost of genetic analysis. In particular, significant advances in label-free methods have been reported. Yet detection of DNA molecules at concentrations below the femtomolar level requires amplified detection schemes. Here we report a unique nanomechanical response of hybridized DNA and RNA molecules that serves as an intrinsic molecular label. Nanomechanical measurements on a microarray surface have sufficient background signal rejection to allow direct detection and counting of hybridized molecules. The digital response of the sensor provides a large dynamic range that is critical for gene expression profiling. We have measured differential expressions of microRNAs in tumour samples; such measurements have been shown to help discriminate between the tissue origins of metastatic tumours. Two hundred picograms of total RNA is found to be sufficient for this analysis. In addition, the limit of detection in pure samples is found to be one attomolar. These results suggest that nanomechanical read-out of microarrays promises attomolar-level sensitivity and large dynamic range for the analysis of gene expression, while eliminating biochemical manipulations, amplification and labelling.

Direct Demonstration of the Concept of Unrestricted Effective-Medium Approximation

NASA Technical Reports Server (NTRS)

Mishchenko, Michael I.; Dlugach, Zhanna M.; Zakharova, Nadezhda T.

2014-01-01

The modified unrestricted effective-medium refractive index is defined as one that yields accurate values of a representative set of far-field scattering characteristics (including the scattering matrix) for an object made of randomly heterogeneous materials. We validate the concept of the modified unrestricted effective-medium refractive index by comparing numerically exact superposition T-matrix results for a spherical host randomly filled with a large number of identical small inclusions and Lorenz-Mie results for a homogeneous spherical counterpart. A remarkable quantitative agreement between the superposition T-matrix and Lorenz-Mie scattering matrices over the entire range of scattering angles demonstrates unequivocally that the modified unrestricted effective-medium refractive index is a sound (albeit still phenomenological) concept provided that the size parameter of the inclusions is sufficiently small and their number is sufficiently large. Furthermore, it appears that in cases when the concept of the modified unrestricted effective-medium refractive index works, its actual value is close to that predicted by the Maxwell-Garnett mixing rule.

Range estimates of whale signals recorded by triplets of hydrophones.

NASA Astrophysics Data System (ADS)

Le Bras, R. J.; Nielsen, P.

2017-12-01

The International Monitoring System of the Comprehensive Nuclear-Test-Ban Treaty Organization includes a hydroacoustic network as one of the monitoring technologies. The underwater part of this network includes six stations and is now complete with the recent installation of the HA04 station located in the Southern Ocean island of Crozet (France). A large number of calls emanating from marine mammals are recorded by the hydrophones, and we present examples where the animals are sufficiently close that a range estimate can be attempted. We also present examples of scattered arrivals and related interpretations.

Range-Gated Metrology: An Ultra-Compact Sensor for Dimensional Stabilization

NASA Technical Reports Server (NTRS)

Lay, Oliver P.; Dubovitsky, Serge; Shaddock, Daniel A.; Ware, Brent; Woodruff, Christopher S.

2008-01-01

Point-to-point laser metrology systems can be used to stabilize large structures at the nanometer levels required for precision optical systems. Existing sensors are large and intrusive, however, with optical heads that consist of several optical elements and require multiple optical fiber connections. The use of point-to-point laser metrology has therefore been limited to applications where only a few gauges are needed and there is sufficient space to accommodate them. Range-Gated Metrology is a signal processing technique that preserves nanometer-level or better performance while enabling: (1) a greatly simplified optical head - a single fiber optic collimator - that can be made very compact, and (2) a single optical fiber connection that is readily multiplexed. This combination of features means that it will be straightforward and cost-effective to embed tens or hundreds of compact metrology gauges to stabilize a large structure. In this paper we describe the concept behind Range-Gated Metrology, demonstrate the performance in a laboratory environment, and give examples of how such a sensor system might be deployed.

Fast and accurate focusing analysis of large photon sieve using pinhole ring diffraction model.

PubMed

Liu, Tao; Zhang, Xin; Wang, Lingjie; Wu, Yanxiong; Zhang, Jizhen; Qu, Hemeng

2015-06-10

In this paper, we developed a pinhole ring diffraction model for the focusing analysis of a large photon sieve. Instead of analyzing individual pinholes, we discuss the focusing of all of the pinholes in a single ring. An explicit equation for the diffracted field of individual pinhole ring has been proposed. We investigated the validity range of this generalized model and analytically describe the sufficient conditions for the validity of this pinhole ring diffraction model. A practical example and investigation reveals the high accuracy of the pinhole ring diffraction model. This simulation method could be used for fast and accurate focusing analysis of a large photon sieve.

FAST TRACK COMMUNICATION: Stable propagation of a modulated positron beam in a bent crystal channel

NASA Astrophysics Data System (ADS)

Kostyuk, A.; Korol, A. V.; Solov'yov, A. V.; Greiner, W.

2010-08-01

The propagation of a modulated positron beam in a planar crystal channel is investigated. It is demonstrated that the beam preserves its modulation at sufficiently large penetration depths, which opens the prospect of using a crystalline undulator as a coherent source of hard x-rays. This finding is a crucial milestone in developing a new type of laser radiating in the hard x-ray and gamma-ray range.

High-Resolution Autoradiography

DTIC Science & Technology

1955-01-01

alloy the tungsten concontrationl of it 1-mnicron culbe is: (8,9 gmI) (8.88 mcg m1-2nl/micron gradient will probably not be so sharp am fit( gradients ...phases of Ilite work: (a) Applicattion and( develop- lie( iiirkeh used. ment (If the( wet-process autorodiographic method will (b)i Trwo methods exist...34 concentration gradients are sufficiently large, the same solution since the range of beta particles in water Wet-process autoradiography as developed for

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yokosawa, A.

The first polarized collider, where we collide 250 GeV/c beams of 70% polarized protons at high luminosity, is under construction. This will allow a determination of the nuclear spin-dependent structure functions over a large range in x, and a collection of sufficient W and Z events to investigate extremely interesting spin-related phenomena. For these measurements, two major RHIC detectors will be used simultaneously whose functions are complimentary. Expected event rates given in this paper are for the STAR detector.

Deficiencies in Natura 2000 for protecting recovering large carnivores: A spotlight on the wolf Canis lupus in Poland.

PubMed

Diserens, Tom A; Borowik, Tomasz; Nowak, Sabina; Szewczyk, Maciej; Niedźwiecka, Natalia; Mysłajek, Robert W

2017-01-01

If protected areas are to remain relevant in our dynamic world they must be adapted to changes in species ranges. In the EU one of the most notable such changes is the recent recovery of large carnivores, which are protected by Natura 2000 at the national and population levels. However, the Natura 2000 network was designed prior to their recent recovery, which raises the question whether the network is sufficient to protect the contemporary ranges of large carnivores. To investigate this question we evaluated Natura 2000 coverage of the three wolf Canis lupus populations in Poland. Wolf tracking data showed that wolves have recolonised almost all suitable habitat in Poland (as determined by a recent habitat suitability model), so we calculated the overlap between the Natura 2000 network and all wolf habitat in Poland. On the basis of published Natura 2000 criteria, we used 20% as the minimum required coverage. At the national level, wolves are sufficiently protected (22% coverage), but at the population level, the Baltic and Carpathian populations are far better protected (28 and 47%, respectively) than the endangered Central European Lowland population (12%). As Natura 2000 insufficiently protects the most endangered wolf population in Poland, we recommend expansion of Natura 2000 to protect at least an additional 8% of wolf habitat in western Poland, and discuss which specific forests are most in need of additional coverage. Implementation of these actions will have positive conservation implications and help Poland to fulfil its Habitats Directive obligations. As it is likely that similar gaps in Natura 2000 are arising in other EU member states experiencing large carnivore recoveries, particularly in Central Europe, we make the case for a flexible approach to Natura 2000 and suggest that such coverage evaluations may be beneficial elsewhere.

Clear, Conductive, Transparent, Flexible Space Durable Composite Films for Electrostatic Charge Mitigation

NASA Technical Reports Server (NTRS)

Watson, Kent A.; Connell, John W.; Delozier, Donavon M.; Smith, Joseph G., Jr.

2004-01-01

Space environmentally durable polymeric films with low color and sufficient electrical conductivity to mitigate electrostatic charge (ESC) build-up have been under investigation as part of a materials development activity. These materials have potential applications on advanced spacecraft, particularly on large, deployable, ultra-light weight Gossamer spacecraft. The approach taken to impart sufficient electrical conductivity into the polymer film while maintaining flexibility is to use single wall carbon nanotubes (SWNTs) as conductive additives. Approaches investigated in our lab involved an in-situ polymerization method, addition of SWNTs to a polymer containing reactive end-groups, and spray coating of polymer surfaces. The work described herein is a summary of the current status of this project. Surface conductivities (measured as surface resistance) in the range sufficient for ESC mitigation were achieved with minimal effects on the physical, thermal, mechanical and optical properties of the films. Additionally, the electrical conductivity was not affected by harsh mechanical manipulation of the films. The chemistry and physical properties of these nanocomposites will be discussed.

Tank Investigation of a Powered Dynamic Model of a Large Long-Range Flying Boat

NASA Technical Reports Server (NTRS)

Parkinson, John B; Olson, Roland E; Harr, Marvin I

1947-01-01

Principles for designing the optimum hull for a large long-range flying boat to meet the requirements of seaworthiness, minimum drag, and ability to take off and land at all operational gross loads were incorporated in a 1/12-size powered dynamic model of a four-engine transport flying boat having a design gross load of 165,000 pounds. These design principles included the selection of a moderate beam loading, ample forebody length, sufficient depth of step, and close adherence to the form of a streamline body. The aerodynamic and hydrodynamic characteristics of the model were investigated in Langley tank no. 1. Tests were made to determine the minimum allowable depth of step for adequate landing stability, the suitability of the fore-and-aft location of the step, the take-off performance, the spray characteristics, and the effects of simple spray-control devices. The application of the design criterions used and test results should be useful in the preliminary design of similar large flying boats.

An investigation of small scales of turbulence in a boundary layer at high Reynolds numbers

NASA Technical Reports Server (NTRS)

Wallace, James M.; Ong, L.; Balint, J.-L.

1993-01-01

The assumption that turbulence at large wave-numbers is isotropic and has universal spectral characteristics which are independent of the flow geometry, at least for high Reynolds numbers, has been a cornerstone of closure theories as well as of the most promising recent development in the effort to predict turbulent flows, viz. large eddy simulations. This hypothesis was first advanced by Kolmogorov based on the supposition that turbulent kinetic energy cascades down the scales (up the wave-numbers) of turbulence and that, if the number of these cascade steps is sufficiently large (i.e. the wave-number range is large), then the effects of anisotropies at the large scales are lost in the energy transfer process. Experimental attempts were repeatedly made to verify this fundamental assumption. However, Van Atta has recently suggested that an examination of the scalar and velocity gradient fields is necessary to definitively verify this hypothesis or prove it to be unfounded. Of course, this must be carried out in a flow with a sufficiently high Reynolds number to provide the necessary separation of scales in order unambiguously to provide the possibility of local isotropy at large wave-numbers. An opportunity to use our 12-sensor hot-wire probe to address this issue directly was made available at the 80'x120' wind tunnel at the NASA Ames Research Center, which is normally used for full-scale aircraft tests. An initial report on this high Reynolds number experiment and progress toward its evaluation is presented.

Towards clinical computed ultrasound tomography in echo-mode: Dynamic range artefact reduction.

PubMed

Jaeger, Michael; Frenz, Martin

2015-09-01

Computed ultrasound tomography in echo-mode (CUTE) allows imaging the speed of sound inside tissue using hand-held pulse-echo ultrasound. This technique is based on measuring the changing local phase of beamformed echoes when changing the transmit beam steering angle. Phantom results have shown a spatial resolution and contrast that could qualify CUTE as a promising novel diagnostic modality in combination with B-mode ultrasound. Unfortunately, the large intensity range of several tens of dB that is encountered in clinical images poses difficulties to echo phase tracking and results in severe artefacts. In this paper we propose a modification to the original technique by which more robust echo tracking can be achieved, and we demonstrate in phantom experiments that dynamic range artefacts are largely eliminated. Dynamic range artefact reduction also allowed for the first time a clinical implementation of CUTE with sufficient contrast to reproducibly distinguish the different speed of sound in different tissue layers of the abdominal wall and the neck. Copyright © 2015. Published by Elsevier B.V.

Radiocarbon dating of extinct fauna in the Americas recovered from tar pits

NASA Astrophysics Data System (ADS)

Jull, A. J. T.; Iturralde-Vinent, M.; O'Malley, J. M.; MacPhee, R. D. E.; McDonald, H. G.; Martin, P. S.; Moody, J.; Rincón, A.

2004-08-01

We have obtained radiocarbon dates by accelerator mass spectrometry on bones of extinct large mammals from tar pits. Results on some samples of Glyptodon and Holmesina (extinct large mammals similar to armadillos) yielded ages of >25 and >21 ka, respectively. We also studied the radiocarbon ages of three different samples of bones from the extinct Cuban ground sloth, Parocnus bownii, which yielded dates ranging from 4960 ± 280 to 11 880 ± 420 yr BP. In order to remove the tar component pretreat the samples sufficiently to obtain reliable dates, we cleaned the samples by Soxhlet extraction in benzene. Resulting samples of collagenous material were often small.

The rise of agrarian capitalism and the decline of family farming in England.

PubMed

Shaw-Taylor, Leigh

2012-01-01

Historians have documented rising farm sizes throughout the period 1450–1850. Existing studies have revealed much about the mechanisms underlying the development of agrarian capitalism. However, we currently lack any consensus as to when the critical developments occurred. This is largely due to the absence of sufficiently large and geographically wide-ranging datasets but is also attributable to conceptual weaknesses in much of the literature. This article develops a new approach to the problem and argues that agrarian capitalism was dominant in southern and eastern England by 1700 but that in northern England the critical developments came later.

Complex magnetic susceptibility setup for spectroscopy in the extremely low-frequency range.

PubMed

Kuipers, B W M; Bakelaar, I A; Klokkenburg, M; Erné, B H

2008-01-01

A sensitive balanced differential transformer was built to measure complex initial parallel magnetic susceptibility spectra in the 0.01-1000 Hz range. The alternating magnetic field can be chosen sufficiently weak that the magnetic structure of the samples is only slightly perturbed and the low frequencies make it possible to study the rotational dynamics of large magnetic colloidal particles or aggregates dispersed in a liquid. The distinguishing features of the setup are the novel multilayered cylindrical coils with a large sample volume and a large number of secondary turns (55 000) to measure induced voltages with a good signal-to-noise ratio, the use of a dual channel function generator to provide an ac current to the primary coils and an amplitude- and phase-adjusted compensation voltage to the dual phase differential lock-in amplifier, and the measurement of several vector quantities at each frequency. We present the electrical impedance characteristics of the coils, and we demonstrate the performance of the setup by measurement on magnetic colloidal dispersions covering a wide range of characteristic relaxation frequencies and magnetic susceptibilities, from chi approximately -10(-5) for pure water to chi>1 for concentrated ferrofluids.

Functional importance of short-range binding and long-range solvent interactions in helical antifreeze peptides.

PubMed

Ebbinghaus, Simon; Meister, Konrad; Prigozhin, Maxim B; Devries, Arthur L; Havenith, Martina; Dzubiella, Joachim; Gruebele, Martin

2012-07-18

Short-range ice binding and long-range solvent perturbation both have been implicated in the activity of antifreeze proteins and antifreeze glycoproteins. We study these two mechanisms for activity of winter flounder antifreeze peptide. Four mutants are characterized by freezing point hysteresis (activity), circular dichroism (secondary structure), Förster resonance energy transfer (end-to-end rigidity), molecular dynamics simulation (structure), and terahertz spectroscopy (long-range solvent perturbation). Our results show that the short-range model is sufficient to explain the activity of our mutants, but the long-range model provides a necessary condition for activity: the most active peptides in our data set all have an extended dynamical hydration shell. It appears that antifreeze proteins and antifreeze glycoproteins have reached different evolutionary solutions to the antifreeze problem, utilizing either a few precisely positioned OH groups or a large quantity of OH groups for ice binding, assisted by long-range solvent perturbation. Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Large- and small-scale constraints on power spectra in Omega = 1 universes

NASA Technical Reports Server (NTRS)

Gelb, James M.; Gradwohl, Ben-Ami; Frieman, Joshua A.

1993-01-01

The CDM model of structure formation, normalized on large scales, leads to excessive pairwise velocity dispersions on small scales. In an attempt to circumvent this problem, we study three scenarios (all with Omega = 1) with more large-scale and less small-scale power than the standard CDM model: (1) cold dark matter with significantly reduced small-scale power (inspired by models with an admixture of cold and hot dark matter); (2) cold dark matter with a non-scale-invariant power spectrum; and (3) cold dark matter with coupling of dark matter to a long-range vector field. When normalized to COBE on large scales, such models do lead to reduced velocities on small scales and they produce fewer halos compared with CDM. However, models with sufficiently low small-scale velocities apparently fail to produce an adequate number of halos.

PLANETESIMAL FORMATION IN MAGNETOROTATIONALLY DEAD ZONES: CRITICAL DEPENDENCE ON THE NET VERTICAL MAGNETIC FLUX

DOE Office of Scientific and Technical Information (OSTI.GOV)

Okuzumi, Satoshi; Hirose, Shigenobu, E-mail: okuzumi@nagoya-u.jp

Turbulence driven by magnetorotational instability (MRI) affects planetesimal formation by inducing diffusion and collisional fragmentation of dust particles. We examine conditions preferred for planetesimal formation in MRI-inactive 'dead zones' using an analytic dead-zone model based on our recent resistive MHD simulations. We argue that successful planetesimal formation requires not only a sufficiently large dead zone (which can be produced by tiny dust grains) but also a sufficiently small net vertical magnetic flux (NVF). Although often ignored, the latter condition is indeed important since the NVF strength determines the saturation level of turbulence in MRI-active layers. We show that direct collisionalmore » formation of icy planetesimal across the fragmentation barrier is possible when the NVF strength is lower than 10 mG (for the minimum-mass solar nebula model). Formation of rocky planetesimals via the secular gravitational instability is also possible within a similar range of the NVF strength. Our results indicate that the fate of planet formation largely depends on how the NVF is radially transported in the initial disk formation and subsequent disk accretion processes.« less

Bose-Einstein condensation in chains with power-law hoppings: Exact mapping on the critical behavior in d-dimensional regular lattices.

PubMed

Dias, W S; Bertrand, D; Lyra, M L

2017-06-01

Recent experimental progress on the realization of quantum systems with highly controllable long-range interactions has impelled the study of quantum phase transitions in low-dimensional systems with power-law couplings. Long-range couplings mimic higher-dimensional effects in several physical contexts. Here, we provide the exact relation between the spectral dimension d at the band bottom and the exponent α that tunes the range of power-law hoppings of a one-dimensional ideal lattice Bose gas. We also develop a finite-size scaling analysis to obtain some relevant critical exponents and the critical temperature of the BEC transition. In particular, an irrelevant dangerous scaling field has to be taken into account when the hopping range is sufficiently large to make the effective dimensionality d>4.

Bose-Einstein condensation in chains with power-law hoppings: Exact mapping on the critical behavior in d -dimensional regular lattices

NASA Astrophysics Data System (ADS)

Dias, W. S.; Bertrand, D.; Lyra, M. L.

2017-06-01

Recent experimental progress on the realization of quantum systems with highly controllable long-range interactions has impelled the study of quantum phase transitions in low-dimensional systems with power-law couplings. Long-range couplings mimic higher-dimensional effects in several physical contexts. Here, we provide the exact relation between the spectral dimension d at the band bottom and the exponent α that tunes the range of power-law hoppings of a one-dimensional ideal lattice Bose gas. We also develop a finite-size scaling analysis to obtain some relevant critical exponents and the critical temperature of the BEC transition. In particular, an irrelevant dangerous scaling field has to be taken into account when the hopping range is sufficiently large to make the effective dimensionality d >4 .

Carbon dioxide hydrate and floods on Mars

NASA Technical Reports Server (NTRS)

Milton, D. J.

1974-01-01

Ground ice on Mars probably consists largely of carbon dioxide hydrate. This hydrate dissociates upon release of pressure at temperatures between 0 and 10 C. The heat capacity of the ground would be sufficient to produce up to 4% (by volume) of water at a rate equal to that at which it can be drained away. Catastrophic dissociation of carbon dioxide hydrate during some past epoch when the near-surface temperature was in this range would have produced chaotic terrain and flood channels.

Force Characteristics in the Submerged and Planing Condition of a 1/5.78-Scale Model of a Hydro-Ski-Wheel Combination for the Grumman JRF-5 Airplane. TED No. NACA DE 357

NASA Technical Reports Server (NTRS)

Land, Norman S.; Pelz, Charles A.

1952-01-01

Force characteristics determined from tank tests of a 1/5.78 scale model of a hydro-ski-wheel combination for the Grumman JRF-5 airplane are presented. The model was tested in both the submerged and planing conditions over a range of trim, speed, and load sufficiently large to represent the most probable full-size conditions.

Behavior of a nuclear steel containment equipment hatch at large strain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fanous, F.; Greimann, L.

1988-05-01

During a severe accident, buckling of a steel containment hatch door, large deformation and ovaling of the hatch sleeve are potential causes of mismatch at the sealing surface which can result in a leakage path. A three-dimensional nonlinear finite element analysis of a typical steel containment/sleeve/hatch assembly that includes containment stiffeners, pretensioned swing bolts, and hatch door geometric imperfection is presented. The analysis was carried out to the nonlinear range up to large strains. The results indicated that the buckling load occurs at pressure, far above that which causes gross yielding of the shell plate. Although buckling of the hatchmore » door increased the relative motions of the hatch sleeve and the hatch door, the motions remained sufficiently small to prevent leakage.« less

English community pharmacists’ experiences of using electronic transmission of prescriptions: a qualitative study

PubMed Central

2013-01-01

Background The Electronic Prescription Service Release 2 (EPS2) in England has been designed to provide electronic transmission of digitally-signed prescriptions between primary care providers, with the intent on removing the large amounts of paper currently exchanged. As part of a wider evaluation of the EPS service, we wished to explore pharmacists’ experience with the new system and their perceptions of its benefits and any associated problems. Methods We conducted semi-structured telephone interviews with community pharmacists using EPS2. We used a purposive sampling technique to obtain views from pharmacists working in pharmacies with a range of sizes and locations and to include both independent pharmacies and multiples. Interviews were transcribed verbatim and coded using grounded theory to identify the main factors that have influenced deployment and implementation in the eyes of respondents. QSR Nvivo was used as to aid in this process. Results It became apparent from the analysis that respondents perceived a wide range of advantages of EPS including improved safety, stock control, time management and improved relationships between pharmacy and General Practice staff. Respondents did not perceive a large difference in terms of work processes or development of their professional role. A large number of problems had been experienced in relation to both the technology itself and the way it was used by General Practices. It became apparent that work-around procedures had been developed for dealing with these issues but that not all these problems were perceived as having been addressed sufficiently at source. This sometimes had implications for the extent of EPS2 use and also limited some of the potential advantages of the EPS2 system, such as reduced effort in the management of prescription reimbursement. Respondents made suggestions for future improvements to EPS2. While interview data demonstrated that there were some feedback procedures in place, these were not regarded as being sufficient by the majority of respondents. Conclusions Whilst pharmacists perceived a wide range of benefits of EPS, a large number of problems had been experienced. Despite these difficulties, no pharmacists expressed an overall negative view. PMID:24152293

English community pharmacists' experiences of using electronic transmission of prescriptions: a qualitative study.

PubMed

Garfield, Sara; Hibberd, Ralph; Barber, Nick

2013-10-23

The Electronic Prescription Service Release 2 (EPS2) in England has been designed to provide electronic transmission of digitally-signed prescriptions between primary care providers, with the intent on removing the large amounts of paper currently exchanged. As part of a wider evaluation of the EPS service, we wished to explore pharmacists' experience with the new system and their perceptions of its benefits and any associated problems. We conducted semi-structured telephone interviews with community pharmacists using EPS2. We used a purposive sampling technique to obtain views from pharmacists working in pharmacies with a range of sizes and locations and to include both independent pharmacies and multiples. Interviews were transcribed verbatim and coded using grounded theory to identify the main factors that have influenced deployment and implementation in the eyes of respondents. QSR Nvivo was used as to aid in this process. It became apparent from the analysis that respondents perceived a wide range of advantages of EPS including improved safety, stock control, time management and improved relationships between pharmacy and General Practice staff. Respondents did not perceive a large difference in terms of work processes or development of their professional role. A large number of problems had been experienced in relation to both the technology itself and the way it was used by General Practices. It became apparent that work-around procedures had been developed for dealing with these issues but that not all these problems were perceived as having been addressed sufficiently at source. This sometimes had implications for the extent of EPS2 use and also limited some of the potential advantages of the EPS2 system, such as reduced effort in the management of prescription reimbursement. Respondents made suggestions for future improvements to EPS2. While interview data demonstrated that there were some feedback procedures in place, these were not regarded as being sufficient by the majority of respondents. Whilst pharmacists perceived a wide range of benefits of EPS, a large number of problems had been experienced. Despite these difficulties, no pharmacists expressed an overall negative view.

Ionospheric Refraction Corrections in the GTDS for Satellite-To-Satellite Tracking Data

NASA Technical Reports Server (NTRS)

Nesterczuk, G.; Kozelsky, J. K.

1976-01-01

In satellite-to-satellite tracking (SST) geographic as well as diurnal ionospheric effects must be contended with, for the line of sight between satellites can cross a day-night interface or lie within the equatorial ionosphere. These various effects were examined and a method of computing ionospheric refraction corrections to range and range rate measurements with sufficient accuracy were devised to be used in orbit determinations. The Bent Ionospheric Model is used for SST refraction corrections. Making use of this model a method of computing corrections through large ionospheric gradients was devised and implemented into the Goddard Trajectory Determination System. The various considerations taken in designing and implementing this SST refraction correction algorithm are reported.

Some flow phenomena in a constant area duct with a Borda type inlet including the critical region

NASA Technical Reports Server (NTRS)

Hendricks, R. C.; Simoneau, R. J.

1978-01-01

Mass limiting flow characteristics for a 55 L/D tube with a Borda type inlet were assessed over large ranges of temperature and pressure, using fluid nitrogen. Under certain conditions, separation and pressure drop at the inlet was sufficiently strong to permit partial vaporization and the remaining fluid flowed through the tube as if it were a free jet. An empirical relation was determined which defines conditions under which this type of flow can occur. A flow coefficient is presented which enables estimations of flow rates over the experimental range. A flow rate stagnation pressure map for selected stagnation isotherms and pressure profiles document these flow phenomena.

Serum 25(OH)D seasonality in urologic patients from central Italy.

PubMed

Calgani, Alessia; Iarlori, Marco; Rizi, Vincenzo; Pace, Gianna; Bologna, Mauro; Vicentini, Carlo; Angelucci, Adriano

2016-09-01

Hypovitaminosis D is increasingly recognized as a cofactor in several diseases. In addition to bone homeostasis, vitamin D status influences immune system, muscle activity and cell differentiation in different tissues. Vitamin D is produced in the skin upon exposure to UVB rays, and sufficient levels of serum 25(OH)D are dependent mostly on adequate sun exposure, and then on specific physiologic variables, including skin type, age and Body Mass Index (BMI). In contrast with common belief, epidemiologic data are demonstrating that hypovitaminosis D must be a clinical concern not only in northern Countries. In our study, we investigated vitamin D status in a male population enrolled in a urology clinic of central Italy. In addition, we evaluated the correlation between vitamin D status and UVB irradiance measured in our region. The two principal pathologies in the 95 enrolled patients (mean age 66years) were benign prostate hypertrophy and prostate carcinoma. >50% of patients had serum 25(OH)D values in the deficient range (<20ng/mL), and only 16% of cases had serum vitamin D concentration higher than 30ng/mL (optimal range). The seasonal stratification of vitamin D concentrations revealed an evident trend with the minimum mean value recorded in April and a maximum mean value obtained in September. UVB irradiance measured by pyranometer in our region (Abruzzo, central Italy) revealed a large difference during the year, with winter months characterized by an UV irradiance about tenfold lower than summer months. Then we applied a mathematical model in order to evaluate the expected vitamin D production according to the standard erythemal dose measured in the different seasons. In winter months, the low available UVB radiation and the small exposed skin area resulted not sufficient to obtain the recommended serum doses of vitamin D. Although in summer months UVB irradiance was largely in excess to produce vitamin D in the skin, serum vitamin D resulted sufficient in September only in those patients who declared an outdoor time of at least 3h per day in the previous summer. In conclusion, hypovitaminosis D is largely represented in elderly persons in our region. Seasonal fluctuation in serum 25(OH)D was explained by a reduced availability of UVB in winter and by insufficient solar exposure in summer. The relatively high outdoor time that emerged to be correlated with sufficient serum 25(OH)D in autumn warrants further studies to individuate potential risk co-variables for hypovitaminosis D in elderly men. Copyright © 2016 Elsevier B.V. All rights reserved.

FIR Detector Sensitivity, Dynamic Range, and Multiplexing Requirements for the Origins Space Telescope (OST)

NASA Astrophysics Data System (ADS)

Staguhn, Johannes G.

2018-05-01

Spectroscopic, cold, space-based mid-to-far-infrared (FIR) missions, such as the Origins Space Telescope, will require large (tens of kilopixels), ultra-sensitive FIR detector arrays with sufficient dynamic range and high-density multiplexing schemes for the readout, in order to optimize the scientific return while staying within a realistic cost range. Issues like power consumption of multiplexers and their readout are significantly more important for space missions than they are for ground-based or suborbital applications. In terms of the detectors and their configuration into large arrays, significant development efforts are needed even for both of the most mature candidate superconducting detector technologies, namely transition edge sensors and (microwave) kinetic inductance detectors. Here we explore both practical and fundamental limits for those technologies in order to lay out a realistic path forward for both technologies. We conclude that beyond the need to enhance the detector sensitivities and pixel numbers by about an order of magnitude over currently existing devices, improved concepts for larger dynamic range and multiplexing density will be needed in order to optimize the scientific return of future cold FIR space missions. Background-limited, very high spectral resolution instruments will require photon-counting detectors.

Path perception during rotation: influence of instructions, depth range, and dot density

NASA Technical Reports Server (NTRS)

Li, Li; Warren, William H Jr

2004-01-01

How do observers perceive their direction of self-motion when traveling on a straight path while their eyes are rotating? Our previous findings suggest that information from retinal flow and extra-retinal information about eye movements are each sufficient to solve this problem for both perception and active control of self-motion [Vision Res. 40 (2000) 3873; Psych. Sci. 13 (2002) 485]. In this paper, using displays depicting translation with simulated eye rotation, we investigated how task variables such as instructions, depth range, and dot density influenced the visual system's reliance on retinal vs. extra-retinal information for path perception during rotation. We found that path errors were small when observers expected to travel on a straight path or with neutral instructions, but errors increased markedly when observers expected to travel on a curved path. Increasing depth range or dot density did not improve path judgments. We conclude that the expectation of the shape of an upcoming path can influence the interpretation of the ambiguous retinal flow. A large depth range and dense motion parallax are not essential for accurate path perception during rotation, but reference objects and a large field of view appear to improve path judgments.

Long-Range Anti-ferromagnetic Order in Sm2Ti2O7

NASA Astrophysics Data System (ADS)

Mauws, Cole; Sarte, Paul; Hallas, Alannah; Wildes, Andrew; Quilliam, Jeffrey; Luke, Graeme; Gaulin, Bruce; Wiebe, Christopher

The spin ice state has been a key topic in frustrated magnetism for decades. Largely due to the presence of monopole-like excitations, leading to interesting physics. There has been a consistent effort in the field at synthesising new spin ice phases that possess smaller moments in the hopes of increasing the density of magnetic monopoles. As well as investigating the phase when quantum fluctuations dominate over dipolar interactions. Initially Sm2Ti2O7 was thought to be a candidate for a quantum spin ice, possessing a low moment of 1.5 μB in the high-spin case and crystal fields may reduce it to a true spin-1/2 system. However anti-ferromagnetic interactions as well as a lambda-like heat capacity anomaly pointed towards long-range antiferromagnetic order. An isotopically enriched samarium-154 single crystal was taken to the D7 polarized diffuse scattering spectrometer at the ILL. Long-range antiferromagnetic order was observed and indexed onto the all-in all-out structure. This agrees with theoretical predictions of Ising pyrochlore systems with sufficiently large anti-ferromagnetic coupling. NSERC, CFI, CIFAR, CRC.

Unambiguous detection of speciated stabilized Criegee intermediates via gas phase derivatization followed by detection using mass spectrometry

NASA Astrophysics Data System (ADS)

Breitenlechner, Martin; Zaytsev, Alexander; Kroll, Jesse; Hansel, Armin; Keutsch, Frank N.

2017-04-01

Ozonolysis of unsaturated volatile organic compounds proceeds via formation of primary ozonides followed by decomposition leading to Criegee intermediates (CI). Their internal energy, buffer gas density and temperature and number of internal degrees of freedom affect their unimolecular lifetime. Stabilized CI (sCI) have sufficient long lifetimes that their fate is determined by trace gases present in the atmosphere. Due to the lack of reliable measurement techniques - especially for larger CI - their role in atmospheric chemistry still remains largely ambiguous. We present results from an effort trying to close this observational gap by utilizing gas phase derivatization of sCIs followed by detection of the formed complexes with chemical ionization mass spectrometry. Our results suggest that the reactions of, e.g., Hexafluoroacetone (HFA) with a number of sCIs (ranging from CIs containing 2 to 10 carbons) are sufficiently fast so that complete conversion can be achieved when adding HFA at ppm levels - largely independent from the exact reaction rate and the amount of HFA introduced beyond that threshold. Using proton transfer reaction time-of-flight mass spectrometry (PTR-ToF), the protonated covalently bound complexes show little to none fragmentation, have unique mass defects and can therefore be clearly separated from other protonated species. We further highlight both analytical and technical challenges accompanied with the implementation of a detection scheme along this route, comprising a broad range of sCIs present at typically minute atmospheric concentrations.

Many-body localization in Ising models with random long-range interactions

NASA Astrophysics Data System (ADS)

Li, Haoyuan; Wang, Jia; Liu, Xia-Ji; Hu, Hui

2016-12-01

We theoretically investigate the many-body localization phase transition in a one-dimensional Ising spin chain with random long-range spin-spin interactions, Vi j∝|i-j |-α , where the exponent of the interaction range α can be tuned from zero to infinitely large. By using exact diagonalization, we calculate the half-chain entanglement entropy and the energy spectral statistics and use them to characterize the phase transition towards the many-body localization phase at infinite temperature and at sufficiently large disorder strength. We perform finite-size scaling to extract the critical disorder strength and the critical exponent of the divergent localization length. With increasing α , the critical exponent experiences a sharp increase at about αc≃1.2 and then gradually decreases to a value found earlier in a disordered short-ranged interacting spin chain. For α <αc , we find that the system is mostly localized and the increase in the disorder strength may drive a transition between two many-body localized phases. In contrast, for α >αc , the transition is from a thermalized phase to the many-body localization phase. Our predictions could be experimentally tested with an ion-trap quantum emulator with programmable random long-range interactions, or with randomly distributed Rydberg atoms or polar molecules in lattices.

Deficiencies in Natura 2000 for protecting recovering large carnivores: A spotlight on the wolf Canis lupus in Poland

PubMed Central

Borowik, Tomasz; Nowak, Sabina; Szewczyk, Maciej; Niedźwiecka, Natalia; Mysłajek, Robert W.

2017-01-01

If protected areas are to remain relevant in our dynamic world they must be adapted to changes in species ranges. In the EU one of the most notable such changes is the recent recovery of large carnivores, which are protected by Natura 2000 at the national and population levels. However, the Natura 2000 network was designed prior to their recent recovery, which raises the question whether the network is sufficient to protect the contemporary ranges of large carnivores. To investigate this question we evaluated Natura 2000 coverage of the three wolf Canis lupus populations in Poland. Wolf tracking data showed that wolves have recolonised almost all suitable habitat in Poland (as determined by a recent habitat suitability model), so we calculated the overlap between the Natura 2000 network and all wolf habitat in Poland. On the basis of published Natura 2000 criteria, we used 20% as the minimum required coverage. At the national level, wolves are sufficiently protected (22% coverage), but at the population level, the Baltic and Carpathian populations are far better protected (28 and 47%, respectively) than the endangered Central European Lowland population (12%). As Natura 2000 insufficiently protects the most endangered wolf population in Poland, we recommend expansion of Natura 2000 to protect at least an additional 8% of wolf habitat in western Poland, and discuss which specific forests are most in need of additional coverage. Implementation of these actions will have positive conservation implications and help Poland to fulfil its Habitats Directive obligations. As it is likely that similar gaps in Natura 2000 are arising in other EU member states experiencing large carnivore recoveries, particularly in Central Europe, we make the case for a flexible approach to Natura 2000 and suggest that such coverage evaluations may be beneficial elsewhere. PMID:28873090

A proposed origin for palimpsests and anomalous pit craters on Ganymede and Callisto

NASA Technical Reports Server (NTRS)

Croft, S. K.

1983-01-01

The hypothesis that palimpsests and anomalous pit craters are essentially pristine crater forms derived from high-velocity impacts and/or impacts into an ice crust with preimpact temperatures near melting is explored. The observational data are briefly reviewed, and an impact model is proposed for the direct formation of a palimpsest from an impact when the modification flow which produces the final crater is dominated by 'wet' fluid flow, as opposed to the 'dry' granular flow which produces normal craters. Conditions of 'wet' modification occur when the volume of impact melt remaining in the transient crater attains a volume comparable to the transient crater. The normal crater-palimpsest transition is found to occur for sufficiently large impacts or sufficiently fast impactors. The range of crater diameters and morphological characteristics inferred from the impact model is consistent with the observed characteristics of palimpsests and anomalous pit craters.

Multiplex titration RT-PCR: rapid determination of gene expression patterns for a large number of genes

NASA Technical Reports Server (NTRS)

Nebenfuhr, A.; Lomax, T. L.

1998-01-01

We have developed an improved method for determination of gene expression levels with RT-PCR. The procedure is rapid and does not require extensive optimization or densitometric analysis. Since the detection of individual transcripts is PCR-based, small amounts of tissue samples are sufficient for the analysis of expression patterns in large gene families. Using this method, we were able to rapidly screen nine members of the Aux/IAA family of auxin-responsive genes and identify those genes which vary in message abundance in a tissue- and light-specific manner. While not offering the accuracy of conventional semi-quantitative or competitive RT-PCR, our method allows quick screening of large numbers of genes in a wide range of RNA samples with just a thermal cycler and standard gel analysis equipment.

Primordial Black Holes from Supersymmetry in the Early Universe.

PubMed

Cotner, Eric; Kusenko, Alexander

2017-07-21

Supersymmetric extensions of the standard model generically predict that in the early Universe a scalar condensate can form and fragment into Q balls before decaying. If the Q balls dominate the energy density for some period of time, the relatively large fluctuations in their number density can lead to formation of primordial black holes (PBH). Other scalar fields, unrelated to supersymmetry, can play a similar role. For a general charged scalar field, this robust mechanism can generate black holes over the entire mass range allowed by observational constraints, with a sufficient abundance to account for all dark matter in some parameter ranges. In the case of supersymmetry the mass range is limited from above by 10^{23}  g. We also comment on the role that topological defects can play for PBH formation in a similar fashion.

Technique for compressing light intensity ranges utilizing a specifically designed liquid crystal notch filter

DOEpatents

Rushford, Michael C.

1988-01-01

A pin hole camera assembly for use in viewing an object having a relatively large light intensity range, for example a crucible containing molten metal in an atomic vapor laser isotope separation (AVLIS) system is disclosed herein. The assembly includes means for optically compressing the light intensity range appearing at its input sufficient to make it receivable and decipherable by a standard video camera. To accomplish this, the assembly utilizes the combination of interference filter and a liquid crystal notch filter. The latter which preferably includes a cholesteric liquid crystal arrangement is configured to pass light at all wavelengths, except a relatively narrow wavelength band which defines the filter's notch, and includes means for causing the notch to vary to at least a limited extent with the intensity of light at its light incidence surface.

The X-ray luminosity functions of Abell clusters from the Einstein Cluster Survey

NASA Technical Reports Server (NTRS)

Burg, R.; Giacconi, R.; Forman, W.; Jones, C.

1994-01-01

We have derived the present epoch X-ray luminosity function of northern Abell clusters using luminosities from the Einstein Cluster Survey. The sample is sufficiently large that we can determine the luminosity function for each richness class separately with sufficient precision to study and compare the different luminosity functions. We find that, within each richness class, the range of X-ray luminosity is quite large and spans nearly a factor of 25. Characterizing the luminosity function for each richness class with a Schechter function, we find that the characteristic X-ray luminosity, L(sub *), scales with richness class as (L(sub *) varies as N(sub*)(exp gamma), where N(sub *) is the corrected, mean number of galaxies in a richness class, and the best-fitting exponent is gamma = 1.3 +/- 0.4. Finally, our analysis suggests that there is a lower limit to the X-ray luminosity of clusters which is determined by the integrated emission of the cluster member galaxies, and this also scales with richness class. The present sample forms a baseline for testing cosmological evolution of Abell-like clusters when an appropriate high-redshift cluster sample becomes available.

Fluid-membrane tethers: minimal surfaces and elastic boundary layers.

PubMed

Powers, Thomas R; Huber, Greg; Goldstein, Raymond E

2002-04-01

Thin cylindrical tethers are common lipid bilayer membrane structures, arising in situations ranging from micromanipulation experiments on artificial vesicles to the dynamic structure of the Golgi apparatus. We study the shape and formation of a tether in terms of the classical soap-film problem, which is applied to the case of a membrane disk under tension subject to a point force. A tether forms from the elastic boundary layer near the point of application of the force, for sufficiently large displacement. Analytic results for various aspects of the membrane shape are given.

The large area crop inventory experiment: A major demonstration of space remote sensing

NASA Technical Reports Server (NTRS)

Macdonald, R. B.; Hall, F. G.

1977-01-01

Strategies are presented in agricultural technology to increase the resistance of crops to a wider range of meteorological conditions in order to reduce year-to-year variations in crop production. Uncertainties in agricultral production, together with the consumer demands of an increasing world population, have greatly intensified the need for early and accurate annual global crop production forecasts. These forecasts must predict fluctuation with an accuracy, timeliness and known reliability sufficient to permit necessary social and economic adjustments, with as much advance warning as possible.

Collinear interferometer with variable delay for carrier-envelope offset frequency measurement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pawlowska, Monika; Ozimek, Filip; Fita, Piotr

2009-08-15

We demonstrate a novel scheme for measuring the carrier-envelope offset frequency in a femtosecond optical frequency comb. Our method is based on a common-path interferometer with a calcite Babinet-Soleil compensator employed to control the delay between the two interfering beams of pulses. The large delay range (up to 8 ps) of our device is sufficient for systems that rely on spectral broadening in microstructured fibers. We show an experimental proof that the stability of a common-path arrangement is superior to that of the standard interferometers.

Collinear interferometer with variable delay for carrier-envelope offset frequency measurement

NASA Astrophysics Data System (ADS)

Pawłowska, Monika; Ozimek, Filip; Fita, Piotr; Radzewicz, Czesław

2009-08-01

We demonstrate a novel scheme for measuring the carrier-envelope offset frequency in a femtosecond optical frequency comb. Our method is based on a common-path interferometer with a calcite Babinet-Soleil compensator employed to control the delay between the two interfering beams of pulses. The large delay range (up to 8 ps) of our device is sufficient for systems that rely on spectral broadening in microstructured fibers. We show an experimental proof that the stability of a common-path arrangement is superior to that of the standard interferometers.

Range contraction enables harvesting to extinction.

PubMed

Burgess, Matthew G; Costello, Christopher; Fredston-Hermann, Alexa; Pinsky, Malin L; Gaines, Steven D; Tilman, David; Polasky, Stephen

2017-04-11

Economic incentives to harvest a species usually diminish as its abundance declines, because harvest costs increase. This prevents harvesting to extinction. A known exception can occur if consumer demand causes a declining species' harvest price to rise faster than costs. This threat may affect rare and valuable species, such as large land mammals, sturgeons, and bluefin tunas. We analyze a similar but underappreciated threat, which arises when the geographic area (range) occupied by a species contracts as its abundance declines. Range contractions maintain the local densities of declining populations, which facilitates harvesting to extinction by preventing abundance declines from causing harvest costs to rise. Factors causing such range contractions include schooling, herding, or flocking behaviors-which, ironically, can be predator-avoidance adaptations; patchy environments; habitat loss; and climate change. We use a simple model to identify combinations of range contractions and price increases capable of causing extinction from profitable overharvesting, and we compare these to an empirical review. We find that some aquatic species that school or forage in patchy environments experience sufficiently severe range contractions as they decline to allow profitable harvesting to extinction even with little or no price increase; and some high-value declining aquatic species experience severe price increases. For terrestrial species, the data needed to evaluate our theory are scarce, but available evidence suggests that extinction-enabling range contractions may be common among declining mammals and birds. Thus, factors causing range contraction as abundance declines may pose unexpectedly large extinction risks to harvested species.

Range contraction enables harvesting to extinction

PubMed Central

Burgess, Matthew G.; Costello, Christopher; Gaines, Steven D.; Tilman, David; Polasky, Stephen

2017-01-01

Economic incentives to harvest a species usually diminish as its abundance declines, because harvest costs increase. This prevents harvesting to extinction. A known exception can occur if consumer demand causes a declining species’ harvest price to rise faster than costs. This threat may affect rare and valuable species, such as large land mammals, sturgeons, and bluefin tunas. We analyze a similar but underappreciated threat, which arises when the geographic area (range) occupied by a species contracts as its abundance declines. Range contractions maintain the local densities of declining populations, which facilitates harvesting to extinction by preventing abundance declines from causing harvest costs to rise. Factors causing such range contractions include schooling, herding, or flocking behaviors—which, ironically, can be predator-avoidance adaptations; patchy environments; habitat loss; and climate change. We use a simple model to identify combinations of range contractions and price increases capable of causing extinction from profitable overharvesting, and we compare these to an empirical review. We find that some aquatic species that school or forage in patchy environments experience sufficiently severe range contractions as they decline to allow profitable harvesting to extinction even with little or no price increase; and some high-value declining aquatic species experience severe price increases. For terrestrial species, the data needed to evaluate our theory are scarce, but available evidence suggests that extinction-enabling range contractions may be common among declining mammals and birds. Thus, factors causing range contraction as abundance declines may pose unexpectedly large extinction risks to harvested species. PMID:28351981

Collective synthesis of natural products by means of organocascade catalysis

PubMed Central

Jones, Spencer B.; Simmons, Bryon; Mastracchio, Anthony; MacMillan, David W. C.

2012-01-01

Organic chemists are now able to synthesize small quantities of almost any known natural product, given sufficient time, resources and effort. However, translation of the academic successes in total synthesis to the large-scale construction of complex natural products and the development of large collections of biologically relevant molecules present significant challenges to synthetic chemists. Here we show that the application of two nature-inspired techniques, namely organocascade catalysis and collective natural product synthesis, can facilitate the preparation of useful quantities of a range of structurally diverse natural products from a common molecular scaffold. The power of this concept has been demonstrated through the expedient, asymmetric total syntheses of six well-known alkaloid natural products: strychnine, aspidospermidine, vincadifformine, akuammicine, kopsanone and kopsinine. PMID:21753848

Enhancement of gaps in thin graphitic films for heterostructure formation

NASA Astrophysics Data System (ADS)

Hague, J. P.

2014-04-01

There are a large number of atomically thin graphitic films with a structure similar to that of graphene. These films have a spread of band gaps relating to their ionicity and, also, to the substrate on which they are grown. Such films could have a range of applications in digital electronics, where graphene is difficult to use. I use the dynamical cluster approximation to show how electron-phonon coupling between film and substrate can enhance these gaps in a way that depends on the range and strength of the coupling. It is found that one of the driving factors in this effect is a charge density wave instability for electrons on a honeycomb lattice that can open a gap in monolayer graphene. The enhancement at intermediate coupling is sufficiently large that spatially varying substrates and superstrates could be used to create heterostructures in thin graphitic films with position-dependent electron-phonon coupling and gaps, leading to advanced electronic components.

Degradation of radiator performance on Mars due to dust

NASA Technical Reports Server (NTRS)

Gaier, James R.; Perez-Davis, Marla E.; Rutledge, Sharon K.; Forkapa, Mark

1992-01-01

An artificial mineral of the approximate elemental composition of Martian soil was manufactured, crushed, and sorted into four different size ranges. Dust particles from three of these size ranges were applied to arc-textured Nb-1 percent Zr and Cu radiator surfaces to assess their effect on radiator performance. Particles larger than 75 microns did not have sufficient adhesive forces to adhere to the samples at angles greater than about 27 deg. Pre-deposited dust layers were largely removed by clear wind velocities greater than 40 m/s, or by dust-laden wind velocities as low as 25 m/s. Smaller dust grains were more difficult to remove. Abrasion was found to be significant only in high velocity winds (89 m/s or greater). Dust-laden winds were found to be more abrasive than clear wind. Initially dusted samples abraded less than initially clear samples in dust laden wind. Smaller dust particles of the simulant proved to be more abrasive than large. This probably indicates that the larger particles were in fact agglomerates.

Diagnosing prosopagnosia in East Asian individuals: Norms for the Cambridge Face Memory Test-Chinese.

PubMed

McKone, Elinor; Wan, Lulu; Robbins, Rachel; Crookes, Kate; Liu, Jia

2017-07-01

The Cambridge Face Memory Test (CFMT) is widely accepted as providing a valid and reliable tool in diagnosing prosopagnosia (inability to recognize people's faces). Previously, large-sample norms have been available only for Caucasian-face versions, suitable for diagnosis in Caucasian observers. These are invalid for observers of different races due to potentially severe other-race effects. Here, we provide large-sample norms (N = 306) for East Asian observers on an Asian-face version (CFMT-Chinese). We also demonstrate methodological suitability of the CFMT-Chinese for prosopagnosia diagnosis (high internal reliability, approximately normal distribution, norm-score range sufficiently far above chance). Additional findings were a female advantage on mean performance, plus a difference between participants living in the East (China) or the West (international students, second-generation children of immigrants), which we suggest might reflect personality differences associated with willingness to emigrate. Finally, we demonstrate suitability of the CFMT-Chinese for individual differences studies that use correlations within the normal range.

Signal propagation and logic gating in networks of integrate-and-fire neurons.

PubMed

Vogels, Tim P; Abbott, L F

2005-11-16

Transmission of signals within the brain is essential for cognitive function, but it is not clear how neural circuits support reliable and accurate signal propagation over a sufficiently large dynamic range. Two modes of propagation have been studied: synfire chains, in which synchronous activity travels through feedforward layers of a neuronal network, and the propagation of fluctuations in firing rate across these layers. In both cases, a sufficient amount of noise, which was added to previous models from an external source, had to be included to support stable propagation. Sparse, randomly connected networks of spiking model neurons can generate chaotic patterns of activity. We investigate whether this activity, which is a more realistic noise source, is sufficient to allow for signal transmission. We find that, for rate-coded signals but not for synfire chains, such networks support robust and accurate signal reproduction through up to six layers if appropriate adjustments are made in synaptic strengths. We investigate the factors affecting transmission and show that multiple signals can propagate simultaneously along different pathways. Using this feature, we show how different types of logic gates can arise within the architecture of the random network through the strengthening of specific synapses.

Space Durable Polyimide/Carbon Nanotube Composite Films for Electrostatic Charge Mitigation

NASA Technical Reports Server (NTRS)

Watson, Kent A.; Smith, Joseph G., Jr.; Connell, John W.

2003-01-01

Low color, space environmentally durable polymeric films with sufficient electrical conductivity to mitigate electrostatic charge (ESC) build-up have been under investigation as part of a materials development activity. These materials have potential applications on advanced spacecraft, particularly on large, deployable, ultra-light weight Gossamer spacecraft. The approach taken to impart sufficient electrical conductivity into the polymer film is based on the use of single walled carbon nanotubes (SWNT) as conductive additives. Earlier approaches investigated in our lab involved both an in-situ polymerization approach and addition of SWNT to an oligomer containing reactive end-groups as methods to improve SWNT dispersion. The work described herein is based on the spray coating of a SWNT/solvent dispersion onto the film surface. Two types of polyimides were investigated, one with reactive end groups that can lead to bond formation between the oligomer chain and the SWNT surface and those without reactive end-groups. Surface conductivities (measured as surface resistance) in the range sufficient for ESC mitigation were achieved with minimal effects on the mechanical, optical, thermo-optical properties of the film as compared to the other methods. The chemistry and physical properties of these nanocomposites will be discussed.

High-precision Ru isotopic measurements by multi-collector ICP-MS.

PubMed

Becker, Harry; Dalpe, Claude; Walker, Richard J

2002-06-01

Ruthenium isotopic data for a pure Aldrich ruthenium nitrate solution obtained using a Nu Plasma multi collector inductively coupled plasma-mass spectrometer (MC-ICP-MS) shows excellent agreement (better than 1 epsilon unit = 1 part in 10(4)) with data obtained by other techniques for the mass range between 96 and 101 amu. External precisions are at the 0.5-1.7 epsilon level (2sigma). Higher sensitivity for MC ICP-MS compared to negative thermal ionization mass spectrometry (N-TIMS) is offset by the uncertainties introduced by relatively large mass discrimination and instabilities in the plasma source-ion extraction region that affect the long-term reproducibility. Large mass bias correction in ICP mass spectrometry demands particular attention to be paid to the choice of normalizing isotopes. Because of its position in the mass spectrum and the large mass bias correction, obtaining precise and accurate abundance data for 104Ru by MC-ICP-MS remains difficult. Internal and external mass bias correction schemes in this mass range may show similar shortcomings if the isotope of interest does not lie within the mass range covered by the masses used for normalization. Analyses of meteorite samples show that if isobaric interferences from Mo are sufficiently large (Ru/Mo < 10(4)), uncertainties on the Mo interference correction propagate through the mass bias correction and yield inaccurate results for Ru isotopic compositions. Second-order linear corrections may be used to correct for these inaccuracies, but such results are generally less precise than N-TIMS data.

Breakdown of Universality for Unequal-Mass Fermi Gases with Infinite Scattering Length

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blume, D.; Daily, K. M.

We treat small trapped unequal-mass two-component Fermi gases at unitarity within a nonperturbative microscopic framework and investigate the system properties as functions of the mass ratio {kappa}, and the numbers N{sub 1} and N{sub 2} of heavy and light fermions. While equal-mass Fermi gases with infinitely large interspecies s-wave scattering length a{sub s} are universal, we find that unequal-mass Fermi gases are, for sufficiently large {kappa} and in the regime where Efimov physics is absent, not universal. In particular, the (N{sub 1},N{sub 2})=(2,1) and (3, 1) systems exhibit three-body and four-body resonances at {kappa}=12.314(2) and 10.4(2), respectively, as well asmore » surprisingly large finite-range effects. These findings have profound implications for ongoing experimental efforts and quantum simulation proposals that utilize unequal-mass atomic Fermi gases.« less

Cosmic homogeneity: a spectroscopic and model-independent measurement

NASA Astrophysics Data System (ADS)

Gonçalves, R. S.; Carvalho, G. C.; Bengaly, C. A. P., Jr.; Carvalho, J. C.; Bernui, A.; Alcaniz, J. S.; Maartens, R.

2018-03-01

Cosmology relies on the Cosmological Principle, i.e. the hypothesis that the Universe is homogeneous and isotropic on large scales. This implies in particular that the counts of galaxies should approach a homogeneous scaling with volume at sufficiently large scales. Testing homogeneity is crucial to obtain a correct interpretation of the physical assumptions underlying the current cosmic acceleration and structure formation of the Universe. In this letter, we use the Baryon Oscillation Spectroscopic Survey to make the first spectroscopic and model-independent measurements of the angular homogeneity scale θh. Applying four statistical estimators, we show that the angular distribution of galaxies in the range 0.46 < z < 0.62 is consistent with homogeneity at large scales, and that θh varies with redshift, indicating a smoother Universe in the past. These results are in agreement with the foundations of the standard cosmological paradigm.

Finite-size scaling above the upper critical dimension in Ising models with long-range interactions

NASA Astrophysics Data System (ADS)

Flores-Sola, Emilio J.; Berche, Bertrand; Kenna, Ralph; Weigel, Martin

2015-01-01

The correlation length plays a pivotal role in finite-size scaling and hyperscaling at continuous phase transitions. Below the upper critical dimension, where the correlation length is proportional to the system length, both finite-size scaling and hyperscaling take conventional forms. Above the upper critical dimension these forms break down and a new scaling scenario appears. Here we investigate this scaling behaviour by simulating one-dimensional Ising ferromagnets with long-range interactions. We show that the correlation length scales as a non-trivial power of the linear system size and investigate the scaling forms. For interactions of sufficiently long range, the disparity between the correlation length and the system length can be made arbitrarily large, while maintaining the new scaling scenarios. We also investigate the behavior of the correlation function above the upper critical dimension and the modifications imposed by the new scaling scenario onto the associated Fisher relation.

Experimental Investigation on the Basic Law of the Fracture Spatial Morphology for Water Pressure Blasting in a Drillhole Under True Triaxial Stress

NASA Astrophysics Data System (ADS)

Huang, Bingxiang; Li, Pengfeng

2015-07-01

The present literature on the morphology of water pressure blasting fractures in drillholes is not sufficient and does not take triaxial confining stress into account. Because the spatial morphology of water pressure blasting fractures in drillholes is not clear, the operations lack an exact basis. Using a large true triaxial water pressure blasting experimental system and an acoustic emission 3-D positioning system, water pressure blasting experiments on cement mortar test blocks (300 mm × 300 mm × 300 mm) were conducted to study the associated basic law of the fracture spatial morphology. The experimental results show that water pressure blasting does not always generate bubble pulsation. After water pressure blasting under true triaxial stress, a crushed compressive zone and a blasting fracture zone are formed from the inside, with the blasting section of the naked drillhole as the center, to the outside. The shape of the outer edges of the two zones is ellipsoidal. The range of the blasting fracture is large in the radial direction of the drillhole, where the surrounding pressure is large, i.e., the range of the blasting fracture in the drillhole radial cross-section is approximately ellipsoidal. The rock near the drillhole wall is affected by a tensile stress wave caused by the test block boundary reflection, resulting in more flake fractures appearing in the fracturing crack surface in the drillhole axial direction and parallel to the boundary surface. The flake fracture is thin, presenting a small-range flake fracture. The spatial morphology of the water pressure blasting fracture in the drillhole along the axial direction is similar to a wide-mouth Chinese bottle: the crack extent is large near the drillhole orifice, gradually narrows inward along the drillhole axial direction, and then increases into an approximate ellipsoid in the internal naked blasting section. Based on the causes of the crack generation, the blasting cracks are divided into three zones: the blasting shock zone, the axial extension zone, and the orifice influence zone. The explosion shock zone is the range that is directly impacted by the explosive shock waves. The axial extension zone is the axial crack area with uniform width, which is formed when the blasting fracture in the edge of the explosion shock zone extends along the drillhole wall. The extension of the orifice influence zone is very large because the explosion stress waves reflect at the free face and generate tensile stress waves. In the water pressure blasting of the drillhole, the sealing section should be lengthened to allow the drillhole blasting cracks to extend sufficiently under the long-time effect of the blasting stress field of quasi-hydrostatic pressure.

Application of high precision two-way S-band ranging to the navigation of the Galileo Earth encounters

NASA Technical Reports Server (NTRS)

Pollmeier, Vincent M.; Kallemeyn, Pieter H.; Thurman, Sam W.

1993-01-01

The application of high-accuracy S/S-band (2.1 GHz uplink/2.3 GHz downlink) ranging to orbit determination with relatively short data arcs is investigated for the approach phase of each of the Galileo spacecraft's two Earth encounters (8 December 1990 and 8 December 1992). Analysis of S-band ranging data from Galileo indicated that under favorable signal levels, meter-level precision was attainable. It is shown that ranginging data of sufficient accuracy, when acquired from multiple stations, can sense the geocentric angular position of a distant spacecraft. Explicit modeling of ranging bias parameters for each station pass is used to largely remove systematic ground system calibration errors and transmission media effects from the Galileo range measurements, which would otherwise corrupt the angle finding capabilities of the data. The accuracy achieved using the precision range filtering strategy proved markedly better when compared to post-flyby reconstructions than did solutions utilizing a traditional Doppler/range filter strategy. In addition, the navigation accuracy achieved with precision ranging was comparable to that obtained using delta-Differenced One-Way Range, an interferometric measurement of spacecraft angular position relative to a natural radio source, which was also used operationally.

Monitoring Rarity: The Critically Endangered Saharan Cheetah as a Flagship Species for a Threatened Ecosystem

PubMed Central

Belbachir, Farid; Pettorelli, Nathalie; Wacher, Tim; Belbachir-Bazi, Amel; Durant, Sarah M.

2015-01-01

Deserts are particularly vulnerable to human impacts and have already suffered a substantial loss of biodiversity. In harsh and variable desert environments, large herbivores typically occur at low densities, and their large carnivore predators occur at even lower densities. The continued survival of large carnivores is key to healthy functioning desert ecosystems, and the ability to gather reliable information on these rare low density species, including presence, abundance and density, is critical to their monitoring and management. Here we test camera trap methodologies as a monitoring tool for an extremely rare wide-ranging large felid, the critically endangered Saharan cheetah (Acinonyx jubatus hecki). Two camera trapping surveys were carried out over 2–3 months across a 2,551km2 grid in the Ti-n-hağğen region in the Ahaggar Cultural Park, south central Algeria. A total of 32 records of Saharan cheetah were obtained. We show the behaviour and ecology of the Saharan cheetah is severely constrained by the harsh desert environment, leading them to be more nocturnal, be more wide-ranging, and occur at lower densities relative to cheetah in savannah environments. Density estimates ranged from 0.21–0.55/1,000km2, some of the lowest large carnivore densities ever recorded in Africa, and average home range size over 2–3 months was estimated at 1,583km2. We use our results to predict that, in order to detect presence of cheetah with p>0.95 a survey effort of at least 1,000 camera trap days is required. Our study identifies the Ahaggar Cultural Park as a key area for the conservation of the Saharan cheetah. The Saharan cheetah meets the requirements for a charismatic flagship species that can be used to “market” the Saharan landscape at a sufficiently large scale to help reverse the historical neglect of threatened Saharan ecosystems. PMID:25629400

Monitoring rarity: the critically endangered Saharan cheetah as a flagship species for a threatened ecosystem.

PubMed

Belbachir, Farid; Pettorelli, Nathalie; Wacher, Tim; Belbachir-Bazi, Amel; Durant, Sarah M

2015-01-01

Deserts are particularly vulnerable to human impacts and have already suffered a substantial loss of biodiversity. In harsh and variable desert environments, large herbivores typically occur at low densities, and their large carnivore predators occur at even lower densities. The continued survival of large carnivores is key to healthy functioning desert ecosystems, and the ability to gather reliable information on these rare low density species, including presence, abundance and density, is critical to their monitoring and management. Here we test camera trap methodologies as a monitoring tool for an extremely rare wide-ranging large felid, the critically endangered Saharan cheetah (Acinonyx jubatus hecki). Two camera trapping surveys were carried out over 2-3 months across a 2,551 km2 grid in the Ti-n-hağğen region in the Ahaggar Cultural Park, south central Algeria. A total of 32 records of Saharan cheetah were obtained. We show the behaviour and ecology of the Saharan cheetah is severely constrained by the harsh desert environment, leading them to be more nocturnal, be more wide-ranging, and occur at lower densities relative to cheetah in savannah environments. Density estimates ranged from 0.21-0.55/1,000 km2, some of the lowest large carnivore densities ever recorded in Africa, and average home range size over 2-3 months was estimated at 1,583 km2. We use our results to predict that, in order to detect presence of cheetah with p>0.95 a survey effort of at least 1,000 camera trap days is required. Our study identifies the Ahaggar Cultural Park as a key area for the conservation of the Saharan cheetah. The Saharan cheetah meets the requirements for a charismatic flagship species that can be used to "market" the Saharan landscape at a sufficiently large scale to help reverse the historical neglect of threatened Saharan ecosystems.

Initial Low-Reynolds Number Iced Aerodynamic Performance for CRM Wing

NASA Technical Reports Server (NTRS)

Woodard, Brian; Diebold, Jeff; Broeren, Andy; Potapczuk, Mark; Lee, Sam; Bragg, Michael

2015-01-01

NASA, FAA, ONERA, and other partner organizations have embarked on a significant, collaborative research effort to address the technical challenges associated with icing on large scale, three-dimensional swept wings. These are extremely complex phenomena important to the design, certification and safe operation of small and large transport aircraft. There is increasing demand to balance trade-offs in aircraft efficiency, cost and noise that tend to compete directly with allowable performance degradations over an increasing range of icing conditions. Computational fluid dynamics codes have reached a level of maturity that they are being proposed by manufacturers for use in certification of aircraft for flight in icing. However, sufficient high-quality data to evaluate their performance on iced swept wings are not currently available in the public domain and significant knowledge gaps remain.

Collective synthesis of natural products by means of organocascade catalysis.

PubMed

Jones, Spencer B; Simmons, Bryon; Mastracchio, Anthony; MacMillan, David W C

2011-07-13

Organic chemists are now able to synthesize small quantities of almost any known natural product, given sufficient time, resources and effort. However, translation of the academic successes in total synthesis to the large-scale construction of complex natural products and the development of large collections of biologically relevant molecules present significant challenges to synthetic chemists. Here we show that the application of two nature-inspired techniques, namely organocascade catalysis and collective natural product synthesis, can facilitate the preparation of useful quantities of a range of structurally diverse natural products from a common molecular scaffold. The power of this concept has been demonstrated through the expedient, asymmetric total syntheses of six well-known alkaloid natural products: strychnine, aspidospermidine, vincadifformine, akuammicine, kopsanone and kopsinine. ©2011 Macmillan Publishers Limited. All rights reserved

Holography and the Coleman-Mermin-Wagner theorem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anninos, Dionysios; Hartnoll, Sean A.; Iqbal, Nabil

2010-09-15

In 2+1 dimensions at finite temperature, spontaneous symmetry breaking of global symmetries is precluded by large thermal fluctuations of the order parameter. The holographic correspondence implies that analogous effects must also occur in 3+1 dimensional theories with gauged symmetries in certain curved spacetimes with horizon. By performing a one loop computation in the background of a holographic superconductor, we show that bulk quantum fluctuations wash out the classical order parameter at sufficiently large distance scales. The low temperature phase is seen to exhibit algebraic long-range order. Beyond the specific example we study, holography suggests that IR singular quantum fluctuations ofmore » the fields and geometry will play an interesting role for many 3+1 dimensional asymptotically anti-de Sitter spacetimes with planar horizon.« less

Protein Structure Determination using Metagenome sequence data

PubMed Central

Ovchinnikov, Sergey; Park, Hahnbeom; Varghese, Neha; Huang, Po-Ssu; Pavlopoulos, Georgios A.; Kim, David E.; Kamisetty, Hetunandan; Kyrpides, Nikos C.; Baker, David

2017-01-01

Despite decades of work by structural biologists, there are still ~5200 protein families with unknown structure outside the range of comparative modeling. We show that Rosetta structure prediction guided by residue-residue contacts inferred from evolutionary information can accurately model proteins that belong to large families, and that metagenome sequence data more than triples the number of protein families with sufficient sequences for accurate modeling. We then integrate metagenome data, contact based structure matching and Rosetta structure calculations to generate models for 614 protein families with currently unknown structures; 206 are membrane proteins and 137 have folds not represented in the PDB. This approach provides the representative models for large protein families originally envisioned as the goal of the protein structure initiative at a fraction of the cost. PMID:28104891

Livestock grazing and the desert tortoise in the Mojave Desert

USGS Publications Warehouse

Oldemeyer, John L.

1994-01-01

A large part of the Mojave Desert is not in pristine condition, and some current conditions can be related to past grazing-management practices. No information could be found on densities of the desert tortoise (Gopherus agassizii) or on vegetative conditions of areas that had not been grazed to allow managers a comparison of range conditions with data on tortoises. Experimental information to assess the effect of livestock grazing on tortoises is lacking, and researchers have not yet examined whether the forage that remains after grazing is sufficient to meet the nutritional needs of desert tortoises.

Robust calibration of an optical-lattice depth based on a phase shift

NASA Astrophysics Data System (ADS)

Cabrera-Gutiérrez, C.; Michon, E.; Brunaud, V.; Kawalec, T.; Fortun, A.; Arnal, M.; Billy, J.; Guéry-Odelin, D.

2018-04-01

We report on a method to calibrate the depth of an optical lattice. It consists of triggering the intrasite dipole mode of the cloud by a sudden phase shift. The corresponding oscillatory motion is directly related to the interband frequencies on a large range of lattice depths. Remarkably, for a moderate displacement, a single frequency dominates the oscillation of the zeroth and first orders of the interference pattern observed after a sufficiently long time of flight. The method is robust against atom-atom interactions and the exact value of the extra weak external confinement superimposed to the optical lattice.

Diagnosis and Management of Rumen Acidosis and Bloat in Feedlots.

PubMed

Meyer, Nathan F; Bryant, Tony C

2017-11-01

Ruminal acidosis and ruminal bloat represent the most common digestive disorders in feedlot cattle. Ruminants are uniquely adapted to digest and metabolize a large range of feedstuffs. Although cattle have the ability to handle various feedstuffs, disorders associated with altered ruminal fermentation can occur. Proper ruminal microorganism adaptation and a consistent substrate (ration) help prevent digestive disorders. Feed bunk management, sufficient ration fiber, consistent feed milling, and appropriate response to abnormal weather are additional factors important in prevention of digestive disorders. When digestive disorders are suspected, timely diagnosis is imperative. Copyright © 2017 Elsevier Inc. All rights reserved.

A simulation analysis to characterize the dynamics of vaccinating behaviour on contact networks.

PubMed

Perisic, Ana; Bauch, Chris T

2009-05-28

Human behavior influences infectious disease transmission, and numerous "prevalence-behavior" models have analyzed this interplay. These previous analyses assumed homogeneously mixing populations without spatial or social structure. However, spatial and social heterogeneity are known to significantly impact transmission dynamics and are particularly relevant for certain diseases. Previous work has demonstrated that social contact structure can change the individual incentive to vaccinate, thus enabling eradication of a disease under a voluntary vaccination policy when the corresponding homogeneous mixing model predicts that eradication is impossible due to free rider effects. Here, we extend this work and characterize the range of possible behavior-prevalence dynamics on a network. We simulate transmission of a vaccine-preventable infection through a random, static contact network. Individuals choose whether or not to vaccinate on any given day according to perceived risks of vaccination and infection. We find three possible outcomes for behavior-prevalence dynamics on this type of network: small final number vaccinated and final epidemic size (due to rapid control through voluntary ring vaccination); large final number vaccinated and significant final epidemic size (due to imperfect voluntary ring vaccination), and little or no vaccination and large final epidemic size (corresponding to little or no voluntary ring vaccination). We also show that the social contact structure enables eradication under a broad range of assumptions, except when vaccine risk is sufficiently high, the disease risk is sufficiently low, or individuals vaccinate too late for the vaccine to be effective. For populations where infection can spread only through social contact network, relatively small differences in parameter values relating to perceived risk or vaccination behavior at the individual level can translate into large differences in population-level outcomes such as final size and final number vaccinated. The qualitative outcome of rational, self interested behaviour under a voluntary vaccination policy can vary substantially depending on interactions between social contact structure, perceived vaccine and disease risks, and the way that individual vaccination decision-making is modelled.

A simulation analysis to characterize the dynamics of vaccinating behaviour on contact networks

PubMed Central

2009-01-01

Background Human behavior influences infectious disease transmission, and numerous "prevalence-behavior" models have analyzed this interplay. These previous analyses assumed homogeneously mixing populations without spatial or social structure. However, spatial and social heterogeneity are known to significantly impact transmission dynamics and are particularly relevant for certain diseases. Previous work has demonstrated that social contact structure can change the individual incentive to vaccinate, thus enabling eradication of a disease under a voluntary vaccination policy when the corresponding homogeneous mixing model predicts that eradication is impossible due to free rider effects. Here, we extend this work and characterize the range of possible behavior-prevalence dynamics on a network. Methods We simulate transmission of a vaccine-prevetable infection through a random, static contact network. Individuals choose whether or not to vaccinate on any given day according to perceived risks of vaccination and infection. Results We find three possible outcomes for behavior-prevalence dynamics on this type of network: small final number vaccinated and final epidemic size (due to rapid control through voluntary ring vaccination); large final number vaccinated and significant final epidemic size (due to imperfect voluntary ring vaccination), and little or no vaccination and large final epidemic size (corresponding to little or no voluntary ring vaccination). We also show that the social contact structure enables eradication under a broad range of assumptions, except when vaccine risk is sufficiently high, the disease risk is sufficiently low, or individuals vaccinate too late for the vaccine to be effective. Conclusion For populations where infection can spread only through social contact network, relatively small differences in parameter values relating to perceived risk or vaccination behavior at the individual level can translate into large differences in population-level outcomes such as final size and final number vaccinated. The qualitative outcome of rational, self interested behaviour under a voluntary vaccination policy can vary substantially depending on interactions between social contact structure, perceived vaccine and disease risks, and the way that individual vaccination decision-making is modelled. PMID:19476616

Challenges of microtome‐based serial block‐face scanning electron microscopy in neuroscience

PubMed Central

WANNER, A. A.; KIRSCHMANN, M. A.

2015-01-01

Summary Serial block‐face scanning electron microscopy (SBEM) is becoming increasingly popular for a wide range of applications in many disciplines from biology to material sciences. This review focuses on applications for circuit reconstruction in neuroscience, which is one of the major driving forces advancing SBEM. Neuronal circuit reconstruction poses exceptional challenges to volume EM in terms of resolution, field of view, acquisition time and sample preparation. Mapping the connections between neurons in the brain is crucial for understanding information flow and information processing in the brain. However, information on the connectivity between hundreds or even thousands of neurons densely packed in neuronal microcircuits is still largely missing. Volume EM techniques such as serial section TEM, automated tape‐collecting ultramicrotome, focused ion‐beam scanning electron microscopy and SBEM (microtome serial block‐face scanning electron microscopy) are the techniques that provide sufficient resolution to resolve ultrastructural details such as synapses and provides sufficient field of view for dense reconstruction of neuronal circuits. While volume EM techniques are advancing, they are generating large data sets on the terabyte scale that require new image processing workflows and analysis tools. In this review, we present the recent advances in SBEM for circuit reconstruction in neuroscience and an overview of existing image processing and analysis pipelines. PMID:25907464

Integrated Surface Power Strategy for Mars

NASA Technical Reports Server (NTRS)

Rucker, Michelle

2015-01-01

A National Aeronautics and Space Administration (NASA) study team evaluated surface power needs for a conceptual crewed 500-day Mars mission. This study had four goals: 1. Determine estimated surface power needed to support the reference mission; 2. Explore alternatives to minimize landed power system mass; 3. Explore alternatives to minimize Mars Lander power self-sufficiency burden; and 4. Explore alternatives to minimize power system handling and surface transportation mass. The study team concluded that Mars Ascent Vehicle (MAV) oxygen propellant production drives the overall surface power needed for the reference mission. Switching to multiple, small Kilopower fission systems can potentially save four to eight metric tons of landed mass, as compared to a single, large Fission Surface Power (FSP) concept. Breaking the power system up into modular packages creates new operational opportunities, with benefits ranging from reduced lander self-sufficiency for power, to extending the exploration distance from a single landing site. Although a large FSP trades well for operational complexity, a modular approach potentially allows Program Managers more flexibility to absorb late mission changes with less schedule or mass risk, better supports small precursor missions, and allows a program to slowly build up mission capability over time. A number of Kilopower disadvantages-and mitigation strategies-were also explored.

An innovative piston corer for large‐volume sediment samples

PubMed Central

Haselmair, Alexandra; Stachowitsch, Michael; Zuschin, Martin

2016-01-01

Abstract Coring is one of several standard procedures to extract sediments and their faunas from open marine, estuarine, and limnic environments. Achieving sufficiently deep penetration, obtaining large sediment volumes in single deployments, and avoiding sediment loss upon retrieval remain problematic. We developed a piston corer with a diameter of 16 cm that enables penetration down to 1.5 m in a broad range of soft bottom types, yields sufficient material for multiple analyses, and prevents sediment loss due to a specially designed hydraulic core catcher. A novel extrusion system enables very precise slicing and preserves the original sediment stratification by keeping the liners upright. The corer has moderate purchase costs and a robust and simple design that allows for a deployment from relatively small vessels as available at most marine science institutions. It can easily be operated by two to three researchers rather than by specially trained technicians. In the northern Adriatic Sea, the corer successfully extracted more than 50 cores from a range of fine mud to coarse sand, at water depths from three to 45 m. The initial evaluation of the cores demonstrated their usefulness for fauna sequences along with heavy metal, nutrient and pollutant analyses. Their length is particularly suited for historical ecological work requiring sedimentary and faunal sequences to reconstruct benthic communities over the last millennia. PMID:28111529

Nanoscale Dewetting Transition in Protein Complex Folding

PubMed Central

Hua, Lan; Huang, Xuhui; Liu, Pu; Zhou, Ruhong; Berne, Bruce J.

2011-01-01

In a previous study, a surprising drying transition was observed to take place inside the nanoscale hydrophobic channel in the tetramer of the protein melittin. The goal of this paper is to determine if there are other protein complexes capable of displaying a dewetting transition during their final stage of folding. We searched the entire protein data bank (PDB) for all possible candidates, including protein tetramers, dimers, and two-domain proteins, and then performed the molecular dynamics (MD) simulations on the top candidates identified by a simple hydrophobic scoring function based on aligned hydrophobic surface areas. Our large scale MD simulations found several more proteins, including three tetramers, six dimers, and two two-domain proteins, which display a nanoscale dewetting transition in their final stage of folding. Even though the scoring function alone is not sufficient (i.e., a high score is necessary but not sufficient) in identifying the dewetting candidates, it does provide useful insights into the features of complex interfaces needed for dewetting. All top candidates have two features in common: (1) large aligned (matched) hydrophobic areas between two corresponding surfaces, and (2) large connected hydrophobic areas on the same surface. We have also studied the effect on dewetting of different water models and different treatments of the long-range electrostatic interactions (cutoff vs PME), and found the dewetting phenomena is fairly robust. This work presents a few proteins other than melittin tetramer for further experimental studies of the role of dewetting in the end stages of protein folding. PMID:17608515

Time for pulse traversal through slabs of dispersive and negative ({epsilon}, {mu}) materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nanda, Lipsa; Ramakrishna, S. Anantha

2007-12-15

The traversal times for an electromagnetic pulse traversing a slab of dispersive and dissipative material with negative dielectric permittivity ({epsilon}) and magnetic permeability ({mu}) have been calculated by using the average flow of electromagnetic energy in the medium. The effects of bandwidth of the pulse and dissipation in the medium have been investigated. While both large bandwidth and large dissipation have similar effects in smoothening out the resonant features that appear due to Fabry-Perot resonances, large dissipation can result in very small or even negative traversal times near the resonant frequencies. We have also investigated the traversal times and Wignermore » delay times for obliquely incident pulses and evanescent pulses. The coupling to slab plasmon-polariton modes in frequency ranges with negative {epsilon} or {mu} is shown to result in large traversal times at the resonant conditions. We also find that the group velocity mainly contributes to the delay times for pulses propagating across a slab with n=-1. We have checked that the traversal times are positive and subluminal for pulses with sufficiently large bandwidths.« less

Stellar evolution of high mass based on the Ledoux criterion for convection

NASA Technical Reports Server (NTRS)

Stothers, R.; Chin, C.

1972-01-01

Theoretical evolutionary sequences of models for stars of 15 and 30 solar masses were computed from the zero-age main sequence to the end of core helium burning. During the earliest stages of core helium depletion, the envelope rapidly expands into the red-supergiant configuration. At 15 solar mass, a blue loop on the H-R diagram ensues if the initial metals abundance, initial helium abundance, or C-12 + alpha particle reaction rate is sufficiently large, or if the 3-alpha reaction rate is sufficiently small. These quantities affect the opacity of the base of the outer convection zone, the mass of the core, and the thermal properties of the core. The blue loop occurs abruptly and fully developed when the critical value of any of these quantities is exceeded, and the effective temperature range and fraction of the lifetime of core helium burning during the slow phase of the blue loop vary surprisingly little. At 30 solar mass no blue loop occurs for any reasonable set of input parameters.

Escher in color space: individual-differences multidimensional scaling of color dissimilarities collected with a gestalt formation task.

PubMed

Bimler, David; Kirkland, John; Pichler, Shaun

2004-02-01

The structure of color perception can be examined by collecting judgments about color dissimilarities. In the procedure used here, stimuli are presented three at a time on a computer monitor and the spontaneous grouping of most-similar stimuli into gestalts provides the dissimilarity comparisons. Analysis with multidimensional scaling allows such judgments to be pooled from a number of observers without obscuring the variations among them. The anomalous perceptions of color-deficient observers produce comparisons that are represented well by a geometric model of compressed individual color spaces, with different forms of deficiency distinguished by different directions of compression. The geometrical model is also capable of accommodating the normal spectrum of variation, so that there is greater variation in compression parameters between tests on normal subjects than in those between repeated tests on individual subjects. The method is sufficiently sensitive and the variations sufficiently large that they are not obscured by the use of a range of monitors, even under somewhat loosely controlled conditions.

Colonization of a territory by a stochastic population under a strong Allee effect and a low immigration pressure

NASA Astrophysics Data System (ADS)

Be'er, Shay; Assaf, Michael; Meerson, Baruch

2015-06-01

We study the dynamics of colonization of a territory by a stochastic population at low immigration pressure. We assume a sufficiently strong Allee effect that introduces, in deterministic theory, a large critical population size for colonization. At low immigration rates, the average precolonization population size is small, thus invalidating the WKB approximation to the master equation. We circumvent this difficulty by deriving an exact zero-flux solution of the master equation and matching it with an approximate nonzero-flux solution of the pertinent Fokker-Planck equation in a small region around the critical population size. This procedure provides an accurate evaluation of the quasistationary probability distribution of population sizes in the precolonization state and of the mean time to colonization, for a wide range of immigration rates. At sufficiently high immigration rates our results agree with WKB results obtained previously. At low immigration rates the results can be very different.

Colonization of a territory by a stochastic population under a strong Allee effect and a low immigration pressure.

PubMed

Be'er, Shay; Assaf, Michael; Meerson, Baruch

2015-06-01

We study the dynamics of colonization of a territory by a stochastic population at low immigration pressure. We assume a sufficiently strong Allee effect that introduces, in deterministic theory, a large critical population size for colonization. At low immigration rates, the average precolonization population size is small, thus invalidating the WKB approximation to the master equation. We circumvent this difficulty by deriving an exact zero-flux solution of the master equation and matching it with an approximate nonzero-flux solution of the pertinent Fokker-Planck equation in a small region around the critical population size. This procedure provides an accurate evaluation of the quasistationary probability distribution of population sizes in the precolonization state and of the mean time to colonization, for a wide range of immigration rates. At sufficiently high immigration rates our results agree with WKB results obtained previously. At low immigration rates the results can be very different.

Application of high-precision two-way ranging to Galileo Earth-1 encounter navigation

NASA Technical Reports Server (NTRS)

Pollmeier, V. M.; Thurman, S. W.

1992-01-01

The application of precision two-way ranging to orbit determination with relatively short data arcs is investigated for the Galileo spacecraft's approach to its first Earth encounter (December 8, 1990). Analysis of previous S-band (2.3-GHz) ranging data acquired from Galileo indicated that under good signal conditions submeter precision and 10-m ranging accuracy were achieved. It is shown that ranging data of sufficient accuracy, when acquired from multiple stations, can sense the geocentric angular position of a distant spacecraft. A range data filtering technique, in which explicit modeling of range measurement bias parameters for each station pass is utilized, is shown to largely remove the systematic ground system calibration errors and transmission media effects from the Galileo range measurements, which would otherwise corrupt the angle-finding capabilities of the data. The accuracy of the Galileo orbit solutions obtained with S-band Doppler and precision ranging were found to be consistent with simple theoretical calculations, which predicted that angular accuracies of 0.26-0.34 microrad were achievable. In addition, the navigation accuracy achieved with precision ranging was marginally better than that obtained using delta-differenced one-way range (delta DOR), the principal data type that was previously used to obtain spacecraft angular position measurements operationally.

Physical and Numerical Model Studies of Cross-flow Turbines Towards Accurate Parameterization in Array Simulations

NASA Astrophysics Data System (ADS)

Wosnik, M.; Bachant, P.

2014-12-01

Cross-flow turbines, often referred to as vertical-axis turbines, show potential for success in marine hydrokinetic (MHK) and wind energy applications, ranging from small- to utility-scale installations in tidal/ocean currents and offshore wind. As turbine designs mature, the research focus is shifting from individual devices to the optimization of turbine arrays. It would be expensive and time-consuming to conduct physical model studies of large arrays at large model scales (to achieve sufficiently high Reynolds numbers), and hence numerical techniques are generally better suited to explore the array design parameter space. However, since the computing power available today is not sufficient to conduct simulations of the flow in and around large arrays of turbines with fully resolved turbine geometries (e.g., grid resolution into the viscous sublayer on turbine blades), the turbines' interaction with the energy resource (water current or wind) needs to be parameterized, or modeled. Models used today--a common model is the actuator disk concept--are not able to predict the unique wake structure generated by cross-flow turbines. This wake structure has been shown to create "constructive" interference in some cases, improving turbine performance in array configurations, in contrast with axial-flow, or horizontal axis devices. Towards a more accurate parameterization of cross-flow turbines, an extensive experimental study was carried out using a high-resolution turbine test bed with wake measurement capability in a large cross-section tow tank. The experimental results were then "interpolated" using high-fidelity Navier--Stokes simulations, to gain insight into the turbine's near-wake. The study was designed to achieve sufficiently high Reynolds numbers for the results to be Reynolds number independent with respect to turbine performance and wake statistics, such that they can be reliably extrapolated to full scale and used for model validation. The end product of this work will be a cross-flow turbine actuator line model to be used as an extension to the OpenFOAM computational fluid dynamics (CFD) software framework, which will likely require modifications to commonly-used dynamic stall models, in consideration of the turbines' high angle of attack excursions during normal operation.

The Universe at Moderate Redshift

NASA Technical Reports Server (NTRS)

Cen, Renyue; Ostriker, Jeremiah P.

1997-01-01

The report covers the work done in the past year and a wide range of fields including properties of clusters of galaxies; topological properties of galaxy distributions in terms of galaxy types; patterns of gravitational nonlinear clustering process; development of a ray tracing algorithm to study the gravitational lensing phenomenon by galaxies, clusters and large-scale structure, one of whose applications being the effects of weak gravitational lensing by large-scale structure on the determination of q(0); the origin of magnetic fields on the galactic and cluster scales; the topological properties of Ly(alpha) clouds the Ly(alpha) optical depth distribution; clustering properties of Ly(alpha) clouds; and a determination (lower bound) of Omega(b) based on the observed Ly(alpha) forest flux distribution. In the coming year, we plan to continue the investigation of Ly(alpha) clouds using larger dynamic range (about a factor of two) and better simulations (with more input physics included) than what we have now. We will study the properties of galaxies on 1 - 100h(sup -1) Mpc scales using our state-of-the-art large scale galaxy formation simulations of various cosmological models, which will have a resolution about a factor of 5 (in each dimension) better than our current, best simulations. We will plan to study the properties of X-ray clusters using unprecedented, very high dynamic range (20,000) simulations which will enable us to resolve the cores of clusters while keeping the simulation volume sufficiently large to ensure a statistically fair sample of the objects of interest. The details of the last year's works are now described.

Detection of extrasolar planets by the large deployable reflector

NASA Technical Reports Server (NTRS)

Hollenbach, D. J.; Takahashi, T.

1984-01-01

The best wavelength for observing Jupiter-size planetary companions to stars other than the Sun is one at which a planet's thermal emission is strongest; typically this would occur in the far-infrared region. It is assumed that the orbiting infrared telescope used is diffraction-limited so that the resolution of the planet from the central star is accomplished in the wings of the star's Airy pattern. Proxima Centauri, Barnard's Star, Wolf 359, and Epsilon Eridani are just a few of the many nearest main-sequence stars that could be studied with the large deployable relfector (LDR). The detectability of a planet improves for warmer planets and less luminous stars; therefore, planets around white dwarfs and those young planets which have sufficient internal gravitational energy release so as to cause a significant increase in their temperatures are considered. If white dwarfs are as old as they are usually assumed to be (5-10 billion yr), then only the nearest white dwarf (Sirius B) is within the range of LDR. The Ursa Major cluster and Perseu cluster are within LDR's detection range mainly because of their proximity and young age, respectively.

SUFFICIENT IODINE INTAKE IN SCHOOLCHILDREN FROM THE ZAGREB AREA: ASSESSMENT WITH DRIED BLOD SPOT THYROGLOBULIN AS A NEW FUNCTIONAL BIOMARKER FOR IODINE DEFICIENCY.

PubMed

Jukić, Tomislav; Zimmermann, Michael Bruce; Granić, Roko; Prpić, Marin; Krilić, Drazena; Juresa, Vesna; Katalenić, Marijan; Kusić, Zvonko

2015-12-01

Current methods for assessment of iodine intake in a population comprise measurements of urinary iodine concentration (UIC), thyroid volume by ultrasound (US-Tvol), and newborn TSH. Serum or dried blood spot thyroglobulin (DBS-Tg) is a new promising functional iodine status biomarker in children. In 1996, a new act on universal salt iodination was introduced in Croatia with 25 mg of potassium iodideper kg of salt. In 2002, Croatia finally reached iodine sufficiency. However, in 2009, median UIC in 101 schoolchildren from Zagreb, the capital of Croatia, was 288 µg/L, posing to be excessive. The aim of the study was to assess iodine intake in schoolchildren from the Zagreb area and to evaluate the value of DBS-Tg in schoolchildren as a new functional biomarker of iodine deficiency (and iodine excess). The study was part of a large international study in 6- to 12-year-old children supported by UNICEF, the Swiss Federal Institute of Technology (ETH Zurich) and the International Council for the Control of Iodine Deficiency Disorders (ICCIDD). According to international study results, the median cut-off Tg < 13 µg/L and/or < 3% Tg values > 40 µg/L indicate iodine sufficiency. The study included 159 schoolchildren (median age 9.1 ± 1.4 years) from Zagreb and a nearby small town of Jastrebarsko with measurements of UIC, US-Tvol, DBS-Tg, T4, TSH and iodine content in salt from households of schoolchildren (KI/kg of salt). Overall median UIC was 205 µg/L (range 1-505 µg/L). Thyroid volumes in schoolchildren measured by US were within the normal range according to reference values. Median DBS-Tg in schoolchildren was 12.1 µg/L with 3% of Tg values > 40 µg/L. High Tg values were in the UIC range < 50 µg/L and > 300 µg/L (U-shaped curve of Tg plotted against UIC). All children were euthyroid with geometric mean TSH 0.7 ± 0.3 mU/L and arithmetic mean T4 62 ± 12.5 nmol/L. The mean KI content per kg of salt was 24.9 ± 3.1 mg/kg (range 19-36 mg/kg). Study results indicated iodine sufficiency in schoolchildren from the Zagreb area. Thyroglobulin proved to be a sensitive indicator of both iodine deficiency and iodine excess in children. Iodine content in salt from households of schoolchildren was in good compliance with the Croatian act (20-30 mg KI/kg of salt).

A novel 3D-printed mechanical actuator using centrifugal force for magnetic resonance elastography.

PubMed

Neumann, Wiebke; Schad, Lothar R; Zollner, Frank G

2017-07-01

Magnetic resonance elastography (MRE) is a technique for the quantification of tissue stiffness during MR examinations. It requires consistent methods for mechanical shear wave induction to the region of interest in the human body to reliably quantify elastic properties of soft tissues. This work proposes a novel 3D-printed mechanical actuator using the principle of centrifugal force for wave induction. The driver consists of a 3D-printed turbine vibrator powered by compressed air (located inside the scanner room) and an active driver controlling the pressure of inflowing air (placed outside the scanner room). The generated force of the proposed actuator increases for higher actuation frequencies as opposed to conventionally used air cushions. There, the displacement amplitude decreases with increasing actuation frequency resulting in a smaller signal-to-noise ratio. An initial phantom study is presented which demonstrates the feasibility of the actuator for MRE. The wave-actuation frequency was regulated in a range between 15 Hz and 60 Hz for force measurements and proved sufficiently stable (± 0.3 Hz) for any given nominal frequency. The generated forces depend on the weight of the eccentric unbalance within the turbine and ranged between 0.67 N to 2.70 N (for 15 Hz) and 3.09 N to 7.77 N (for 60 Hz). Therefore, the generated force of the presented actuator increases with rotational speed of the turbine and offers an elegant solution for sufficiently large wave actuation at higher frequencies. In future work, we will investigate an optimal ratio of the weight of unbalance to the size of turbine for appropriately large but tolerable wave actuation for a given nominal frequency.

45 Mbps cat's eye modulating retro-reflector link over 7 Km

NASA Astrophysics Data System (ADS)

Rabinovich, W. S.; Mahon, R.; Goetz, P. G.; Swingen, L.; Murphy, J.; Ferraro, M.; Burris, R.; Suite, M.; Moore, C. I.; Gilbreath, G. C.; Binari, S.

2006-09-01

Modulating retro-reflectors (MRR) allow free space optical links with no need for pointing, tracking or a laser on one end of the link. They work by coupling a passive optical retro-reflector with an optical modulator. The most common kind of MRR uses a corner cube retro-reflector. These devices must have a modulator whose active area is as large as the area of the corner cube. This limits the ability to close longer range high speed links because the large aperture need to return sufficient light implies a large modulator capacitance. To overcome this limitation we developed the concept of a cat's eye MRR. Cat's eye MRRs place the modulator in the focal plane of a lens system designed to passively retro-reflect light. Because the light focuses onto the modulator, a small, low capacitance, modulator can be used with a large optical aperture. However, the position of the focal spot varies with the angle of incidence so an array of modulators must be placed in the focal plane, In addition, to avoid having to drive all the modulator pixels, an angle of arrival sensor must be used. We discuss several cat's eye MRR systems with near diffraction limited performance and bandwidths of 45 Mbps. We also discuss a link to a cat's eye MRR over a 7 Km range.

Effects of short-range order on electronic properties of Zr-Ni glasses as seen from low-temperature specific heat

NASA Astrophysics Data System (ADS)

Kroeger, D. M.; Koch, C. C.; Scarbrough, J. O.; McKamey, C. G.

1984-02-01

Measurements of the low-temperature specific heat Cp of liquid-quenched Zr-Ni glasses for a large number of compositions in the range from 55 to 74 at.% Zr revealed an unusual composition dependence of the density of states at the Fermi level, N(EF). Furthermore, for some compositions the variation of Cp near the superconducting transition temperature Tc indicated the presence of two superconducting phases, i.e., two superconducting transitions were detected. Comparison of the individual Tc's in phase-separated samples to the composition dependence of Tc for all of the samples suggests that amorphous phases with compositions near 60 and 66.7 at.% Zr occur. We discuss these results in terms of an "association model" for liquid alloys (due to Sommer), in which associations of unlike atoms with definite stoichiometries are assumed to exist in equilibrium with unassociated atoms. We conclude that in the composition range studied, associate clusters with the compositions Zr3Ni2 and Zr2Ni occur. In only a few cases are the clusters sufficiently large, compared with the superconducting coherence length, for separate superconducting transitions to be observed. The variation of N(EF) with composition is discussed, as well as the effects of this chemical short-range ordering on the crystallization behavior and glass-forming tendency.

Running Out of Time: Why Elephants Don't Gallop

NASA Astrophysics Data System (ADS)

Noble, Julian V.

2001-11-01

The physics of high speed running implies that galloping becomes impossible for sufficiently large animals. Some authors have suggested that because the strength/weight ratio decreases with size and eventually renders large animals excessively liable to injury when they attempt to gallop. This paper suggests that large animals cannot move their limbs sufficiently rapidly to take advantage of leaving the ground, hence are restricted to walking gaits. >From this point of view the relatively low strength/weight ratio of elephants follows from their inability to gallop, rather than causing it.

NASA,FAA,ONERA Swept-Wing Icing and Aerodynamics: Summary of Research and Current Status

NASA Technical Reports Server (NTRS)

Broeren, Andy

2015-01-01

NASA, FAA, ONERA, and other partner organizations have embarked on a significant, collaborative research effort to address the technical challenges associated with icing on large scale, three-dimensional swept wings. These are extremely complex phenomena important to the design, certification and safe operation of small and large transport aircraft. There is increasing demand to balance trade-offs in aircraft efficiency, cost and noise that tend to compete directly with allowable performance degradations over an increasing range of icing conditions. Computational fluid dynamics codes have reached a level of maturity that they are being proposed by manufacturers for use in certification of aircraft for flight in icing. However, sufficient high-quality data to evaluate their performance on iced swept wings are not currently available in the public domain and significant knowledge gaps remain.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shin, Jaejin; Woo, Jong-Hak; Mulchaey, John S.

We perform a comprehensive study of X-ray cavities using a large sample of X-ray targets selected from the Chandra archive. The sample is selected to cover a large dynamic range including galaxy clusters, groups, and individual galaxies. Using β -modeling and unsharp masking techniques, we investigate the presence of X-ray cavities for 133 targets that have sufficient X-ray photons for analysis. We detect 148 X-ray cavities from 69 targets and measure their properties, including cavity size, angle, and distance from the center of the diffuse X-ray gas. We confirm the strong correlation between cavity size and distance from the X-raymore » center similar to previous studies. We find that the detection rates of X-ray cavities are similar among galaxy clusters, groups and individual galaxies, suggesting that the formation mechanism of X-ray cavities is independent of environment.« less

[Cannabinoids in pain medicine].

PubMed

Karst, M

2018-06-07

The endocannabinoid system (ECS) controls a large number of vital functions. Suboptimal tone of the ECS in certain regions of the nervous system may be associated with disorders that are also associated with pain. Pain and inflammation processes can be modulated by the exogenous supply of cannabinoids. Low-to-moderate pain-relieving effects and in individual cases large pain-relieving effects were observed in randomized, controlled studies of various types of chronic pain. People with chronic neuropathic pain and stress symptoms seem to particularly benefit. The therapeutic range of cannabinoids is small; often small doses are sufficient for clinically significant effects. The "Cannabis-als-Medizin-Gesetz" (cannabis as medicine law) allows the prescription of cannabis preparations under certain conditions. Available data indicate good long-term efficacy and tolerability. However, there is little systematic long-term experience from clinical studies.

Statistical significance test for transition matrices of atmospheric Markov chains

NASA Technical Reports Server (NTRS)

Vautard, Robert; Mo, Kingtse C.; Ghil, Michael

1990-01-01

Low-frequency variability of large-scale atmospheric dynamics can be represented schematically by a Markov chain of multiple flow regimes. This Markov chain contains useful information for the long-range forecaster, provided that the statistical significance of the associated transition matrix can be reliably tested. Monte Carlo simulation yields a very reliable significance test for the elements of this matrix. The results of this test agree with previously used empirical formulae when each cluster of maps identified as a distinct flow regime is sufficiently large and when they all contain a comparable number of maps. Monte Carlo simulation provides a more reliable way to test the statistical significance of transitions to and from small clusters. It can determine the most likely transitions, as well as the most unlikely ones, with a prescribed level of statistical significance.

Investigation of critical burning of fuel droplets. [monopropellants

NASA Technical Reports Server (NTRS)

Faeth, G. M.; Chanin, S.

1974-01-01

The steady combustion characteristics of droplets were considered in combustion chamber environments at various pressures, flow conditions, and ambient oxidizer concentrations for a number of hydrocarbon fuels. Using data obtained earlier, predicted gasification rates were within + or - 30% of measurements when the correction for convection was based upon average properties between the liquid surface and the flame around the droplet. Analysis was also completed for the open loop response of monopropellant droplets, based upon earlier strand combustion results. At the limit of large droplets, where the effect of flame curvature is small, the results suggest sufficient response to provide a viable mechanism for combustion instability in the frequency and droplet size range appropriate to practical combustors. Calculations are still in progress for a broader range of droplet sizes, including conditions where active combustion effects are small.

Short-arc orbit determination using coherent X-band ranging data

NASA Technical Reports Server (NTRS)

Thurman, S. W.; Mcelrath, T. P.; Pollmeier, V. M.

1992-01-01

The use of X-band frequencies in ground-spacecraft and spacecraft-ground telecommunication links for current and future robotic interplanetary missions makes it possible to perform ranging measurements of greater accuracy than previously obtained. It is shown that ranging data of sufficient accuracy, when acquired from multiple stations, can sense the geocentric angular position of a distant spacecraft. The application of high-accuracy S/X-band and X-band ranging to orbit determination with relatively short data arcs is investigated in planetary approach and encounter scenarios. Actual trajectory solutions for the Ulysses spacecraft constructed from S/X-band ranging and Doppler data are presented; error covariance calculations are used to predict the performance of X-band ranging and Doppler data. The Ulysses trajectory solutions indicate that the aim point for the spacecraft's February 1992 Jupiter encounter was predicted to a geocentric accuracy of 0.20 to 0.23/microrad. Explicit modeling of range bias parameters for each station pass is shown to largely remove systematic ground system calibration errors and transmission media effects from the Ulysses range measurements, which would otherwise corrupt the angle finding capabilities of the data. The Ulysses solutions were found to be reasonably consistent with the theoretical results, which suggest that angular accuracies of 0.08 to 0.1/microrad are achievable with X-band ranging.

Digital simulation of an arbitrary stationary stochastic process by spectral representation.

PubMed

Yura, Harold T; Hanson, Steen G

2011-04-01

In this paper we present a straightforward, efficient, and computationally fast method for creating a large number of discrete samples with an arbitrary given probability density function and a specified spectral content. The method relies on initially transforming a white noise sample set of random Gaussian distributed numbers into a corresponding set with the desired spectral distribution, after which this colored Gaussian probability distribution is transformed via an inverse transform into the desired probability distribution. In contrast to previous work, where the analyses were limited to auto regressive and or iterative techniques to obtain satisfactory results, we find that a single application of the inverse transform method yields satisfactory results for a wide class of arbitrary probability distributions. Although a single application of the inverse transform technique does not conserve the power spectra exactly, it yields highly accurate numerical results for a wide range of probability distributions and target power spectra that are sufficient for system simulation purposes and can thus be regarded as an accurate engineering approximation, which can be used for wide range of practical applications. A sufficiency condition is presented regarding the range of parameter values where a single application of the inverse transform method yields satisfactory agreement between the simulated and target power spectra, and a series of examples relevant for the optics community are presented and discussed. Outside this parameter range the agreement gracefully degrades but does not distort in shape. Although we demonstrate the method here focusing on stationary random processes, we see no reason why the method could not be extended to simulate non-stationary random processes. © 2011 Optical Society of America

A simple rule for the evolution of contingent cooperation in large groups

PubMed Central

Schonmann, Roberto H.; Boyd, Robert

2016-01-01

Humans cooperate in large groups of unrelated individuals, and many authors have argued that such cooperation is sustained by contingent reward and punishment. However, such sanctioning systems can also stabilize a wide range of behaviours, including mutually deleterious behaviours. Moreover, it is very likely that large-scale cooperation is derived in the human lineage. Thus, understanding the evolution of mutually beneficial cooperative behaviour requires knowledge of when strategies that support such behaviour can increase when rare. Here, we derive a simple formula that gives the relatedness necessary for contingent cooperation in n-person iterated games to increase when rare. This rule applies to a wide range of pay-off functions and assumes that the strategies supporting cooperation are based on the presence of a threshold fraction of cooperators. This rule suggests that modest levels of relatedness are sufficient for invasion by strategies that make cooperation contingent on previous cooperation by a small fraction of group members. In contrast, only high levels of relatedness allow the invasion by strategies that require near universal cooperation. In order to derive this formula, we introduce a novel methodology for studying evolution in group structured populations including local and global group-size regulation and fluctuations in group size. PMID:26729938

Testing for post-copulatory selection for major histocompatibility complex genotype in a semi-free-ranging primate population.

PubMed

Setchell, Joanna M; Abbott, Kristin M; Gonzalez, Jean-Paul; Knapp, Leslie A

2013-10-01

A large body of evidence suggests that major histocompatibility complex (MHC) genotype influences mate choice. However, few studies have investigated MHC-mediated post-copulatory mate choice under natural, or even semi-natural, conditions. We set out to explore this question in a large semi-free-ranging population of mandrills (Mandrillus sphinx) using MHC-DRB genotypes for 127 parent-offspring triads. First, we showed that offspring MHC heterozygosity correlates positively with parental MHC dissimilarity suggesting that mating among MHC dissimilar mates is efficient in increasing offspring MHC diversity. Second, we compared the haplotypes of the parental dyad with those of the offspring to test whether post-copulatory sexual selection favored offspring with two different MHC haplotypes, more diverse gamete combinations, or greater within-haplotype diversity. Limited statistical power meant that we could only detect medium or large effect sizes. Nevertheless, we found no evidence for selection for heterozygous offspring when parents share a haplotype (large effect size), genetic dissimilarity between parental haplotypes (we could detect an odds ratio of ≥1.86), or within-haplotype diversity (medium-large effect). These findings suggest that comparing parental and offspring haplotypes may be a useful approach to test for post-copulatory selection when matings cannot be observed, as is the case in many study systems. However, it will be extremely difficult to determine conclusively whether post-copulatory selection mechanisms for MHC genotype exist, particularly if the effect sizes are small, due to the difficulty in obtaining a sufficiently large sample. © 2013 Wiley Periodicals, Inc.

The plasma separation process as a pre-cursor for large scale radioisotope production

NASA Astrophysics Data System (ADS)

Stevenson, Nigel R.

2001-07-01

Radioisotope production generally employs either accelerators or reactors to convert stable (usually enriched) isotopes into the desired product species. Radioisotopes have applications in industry, environmental sciences, and most significantly in medicine. The production of many potentially useful radioisotopes is significantly hindered by the lack of availability or by the high cost of key enriched stable isotopes. To try and meet this demand, certain niche enrichment processes have been developed and commercialized. Calutrons, centrifuges, and laser separation processes are some of the devices and techniques being employed to produce large quantities of selective enriched stable isotopes. Nevertheless, the list of enriched stable isotopes in sufficient quantities remains rather limited and this continues to restrict the availability of many radioisotopes that otherwise could have a significant impact on society. The Plasma Separation Process is a newly available commercial technique for producing large quantities of a wide range of enriched isotopes and thereby holds promise of being able to open the door to producing new and exciting applications of radioisotopes in the future.

A new tool called DISSECT for analysing large genomic data sets using a Big Data approach

PubMed Central

Canela-Xandri, Oriol; Law, Andy; Gray, Alan; Woolliams, John A.; Tenesa, Albert

2015-01-01

Large-scale genetic and genomic data are increasingly available and the major bottleneck in their analysis is a lack of sufficiently scalable computational tools. To address this problem in the context of complex traits analysis, we present DISSECT. DISSECT is a new and freely available software that is able to exploit the distributed-memory parallel computational architectures of compute clusters, to perform a wide range of genomic and epidemiologic analyses, which currently can only be carried out on reduced sample sizes or under restricted conditions. We demonstrate the usefulness of our new tool by addressing the challenge of predicting phenotypes from genotype data in human populations using mixed-linear model analysis. We analyse simulated traits from 470,000 individuals genotyped for 590,004 SNPs in ∼4 h using the combined computational power of 8,400 processor cores. We find that prediction accuracies in excess of 80% of the theoretical maximum could be achieved with large sample sizes. PMID:26657010

True Shear Parallel Plate Viscometer

NASA Technical Reports Server (NTRS)

Ethridge, Edwin; Kaukler, William

2010-01-01

This viscometer (which can also be used as a rheometer) is designed for use with liquids over a large temperature range. The device consists of horizontally disposed, similarly sized, parallel plates with a precisely known gap. The lower plate is driven laterally with a motor to apply shear to the liquid in the gap. The upper plate is freely suspended from a double-arm pendulum with a sufficiently long radius to reduce height variations during the swing to negligible levels. A sensitive load cell measures the shear force applied by the liquid to the upper plate. Viscosity is measured by taking the ratio of shear stress to shear rate.

Space shuttle: Aerodynamic heating tests of the MDAC delta wing orbiter and canard booster

NASA Technical Reports Server (NTRS)

Andresen, T. L.

1972-01-01

Design of an efficient thermal protection system for the space shuttle orbiter and booster is discussed, based on knowledge of the thermal environment to be experienced by the vehicles in all flight phases. The complex configurations of these vehicles limit the level of confidence which can be associated with purely analytical thermal environment predictions. Tests were conducted during April and May 1971 using an orbiter and booster model at a 96-in. hypersonic shock tunnel. Both models were tested separately as well as together. A sufficiently large range in Reynolds number was covered so that laminar, transitional, and turbulent data could be obtained.

Determination of hydrogen/deuterium ratio with neutron measurements on MAST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klimek, I., E-mail: iwona.klimek@physics.uu.se; Cecconello, M.; Ericsson, G.

2014-11-15

On MAST, compressional Alfvén eigenmodes can be destabilized by the presence of a sufficiently large population of energetic particles in the plasma. This dependence was studied in a series of very similar discharges in which increasing amounts of hydrogen were puffed into a deuterium plasma. A simple method to estimate the isotopic ratio n{sub H}/n{sub D} using neutron emission measurements is here described. The inferred isotopic ratio ranged from 0.0 to 0.6 and no experimental indication of changes in radial profile of n{sub H}/n{sub D} were observed. These findings are confirmed by TRANSP/NUBEAM simulations of the neutron emission.

On the accuracy of various large axial displacement formulae for crooked columns

NASA Astrophysics Data System (ADS)

Mallis, J.; Kounadis, A. N.

1988-11-01

The axial displacements of an initially crooked, simply supported column, subjected to an axial compressive force at its end, are determined by using several variants of the axial strain-displacement relationship. Their accuracy and range of applicability are thoroughly discussed by comparing the corresponding results with those of the exact elastica analysis in which the compressibility effect of the bar axis is accounted for. Among other findings, the important conclusion is drawn that the simplified linear kinematic relation leads to a sufficiently accurate evaluation of the initial part of the postbuckling path which is of significant importance for structural design purposes.

Sensitivity of electrospray molecular dynamics simulations to long-range Coulomb interaction models

NASA Astrophysics Data System (ADS)

Mehta, Neil A.; Levin, Deborah A.

2018-03-01

Molecular dynamics (MD) electrospray simulations of 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIM-BF4) ion liquid were performed with the goal of evaluating the influence of long-range Coulomb models on ion emission characteristics. The direct Coulomb (DC), shifted force Coulomb sum (SFCS), and particle-particle particle-mesh (PPPM) long-range Coulomb models were considered in this work. The DC method with a sufficiently large cutoff radius was found to be the most accurate approach for modeling electrosprays, but, it is computationally expensive. The Coulomb potential energy modeled by the DC method in combination with the radial electric fields were found to be necessary to generate the Taylor cone. The differences observed between the SFCS and the DC in terms of predicting the total ion emission suggest that the former should not be used in MD electrospray simulations. Furthermore, the common assumption of domain periodicity was observed to be detrimental to the accuracy of the capillary-based electrospray simulations.

Dispersion of speckle suppression efficiency for binary DOE structures: spectral domain and coherent matrix approaches.

PubMed

Lapchuk, Anatoliy; Prygun, Olexandr; Fu, Minglei; Le, Zichun; Xiong, Qiyuan; Kryuchyn, Andriy

2017-06-26

We present the first general theoretical description of speckle suppression efficiency based on an active diffractive optical element (DOE). The approach is based on spectral analysis of diffracted beams and a coherent matrix. Analytical formulae are obtained for the dispersion of speckle suppression efficiency using different DOE structures and different DOE activation methods. We show that a one-sided 2D DOE structure has smaller speckle suppression range than a two-sided 1D DOE structure. Both DOE structures have sufficient speckle suppression range to suppress low-order speckles in the entire visible range, but only the two-sided 1D DOE can suppress higher-order speckles. We also show that a linear shift 2D DOE in a laser projector with a large numerical aperture has higher effective speckle suppression efficiency than the method using switching or step-wise shift DOE structures. The generalized theoretical models elucidate the mechanism and practical realization of speckle suppression.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shanks, Katherine S.; Philipp, Hugh T.; Weiss, Joel T.

Experiments at storage ring light sources as well as at next-generation light sources increasingly require detectors capable of high dynamic range operation, combining low-noise detection of single photons with large pixel well depth. XFEL sources in particular provide pulse intensities sufficiently high that a purely photon-counting approach is impractical. The High Dynamic Range Pixel Array Detector (HDR-PAD) project aims to provide a dynamic range extending from single-photon sensitivity to 10{sup 6} photons/pixel in a single XFEL pulse while maintaining the ability to tolerate a sustained flux of 10{sup 11} ph/s/pixel at a storage ring source. Achieving these goals involves themore » development of fast pixel front-end electronics as well as, in the XFEL case, leveraging the delayed charge collection due to plasma effects in the sensor. A first prototype of essential electronic components of the HDR-PAD readout ASIC, exploring different options for the pixel front-end, has been fabricated. Here, the HDR-PAD concept and preliminary design will be described.« less

Sensitivity of electrospray molecular dynamics simulations to long-range Coulomb interaction models.

PubMed

Mehta, Neil A; Levin, Deborah A

2018-03-01

Molecular dynamics (MD) electrospray simulations of 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIM-BF_{4}) ion liquid were performed with the goal of evaluating the influence of long-range Coulomb models on ion emission characteristics. The direct Coulomb (DC), shifted force Coulomb sum (SFCS), and particle-particle particle-mesh (PPPM) long-range Coulomb models were considered in this work. The DC method with a sufficiently large cutoff radius was found to be the most accurate approach for modeling electrosprays, but, it is computationally expensive. The Coulomb potential energy modeled by the DC method in combination with the radial electric fields were found to be necessary to generate the Taylor cone. The differences observed between the SFCS and the DC in terms of predicting the total ion emission suggest that the former should not be used in MD electrospray simulations. Furthermore, the common assumption of domain periodicity was observed to be detrimental to the accuracy of the capillary-based electrospray simulations.

Controlling the column spacing in isothermal magnetic advection to enable tunable heat and mass transfer.

DOE PAGES

Solis, Kyle Jameson; Martin, James E.

2012-11-01

Isothermal magnetic advection is a recently discovered method of inducing highly organized, non-contact flow lattices in suspensions of magnetic particles, using only uniform ac magnetic fields of modest strength. The initiation of these vigorous flows requires neither a thermal gradient nor a gravitational field and so can be used to transfer heat and mass in circumstances where natural convection does not occur. These advection lattices are comprised of a square lattice of antiparallel flow columns. If the column spacing is sufficiently large compared to the column length, and the flow rate within the columns is sufficiently large, then one wouldmore » expect efficient transfer of both heat and mass. Otherwise, the flow lattice could act as a countercurrent heat exchanger and only mass will be efficiently transferred. Although this latter case might be useful for feeding a reaction front without extracting heat, it is likely that most interest will be focused on using IMA for heat transfer. In this paper we explore the various experimental parameters of IMA to determine which of these can be used to control the column spacing. These parameters include the field frequency, strength, and phase relation between the two field components, the liquid viscosity and particle volume fraction. We find that the column spacing can easily be tuned over a wide range, to enable the careful control of heat and mass transfer.« less

Repulsive vacuum-induced forces on a magnetic particle

NASA Astrophysics Data System (ADS)

Sinha, Kanupriya

2018-03-01

We study the possibility of obtaining a repulsive vacuum-induced force for a magnetic point particle near a surface. Considering the toy model of a particle with an electric-dipole transition and a large magnetic spin, we analyze the interplay between the repulsive magnetic-dipole and the attractive electric-dipole contributions to the total Casimir-Polder force. Particularly noting that the magnetic-dipole interaction is longer ranged than the electric dipole due to the difference in their respective characteristic transition frequencies, we find a regime where the repulsive magnetic contribution to the total force can potentially exceed the attractive electric part in magnitude for a sufficiently large spin. We analyze ways to further enhance the magnitude of the repulsive magnetic Casimir-Polder force for an excited particle, such as by preparing it in a "super-radiant" magnetic sublevel and designing surface resonances close to the magnetic transition frequency.

Locating multiple diffusion sources in time varying networks from sparse observations.

PubMed

Hu, Zhao-Long; Shen, Zhesi; Cao, Shinan; Podobnik, Boris; Yang, Huijie; Wang, Wen-Xu; Lai, Ying-Cheng

2018-02-08

Data based source localization in complex networks has a broad range of applications. Despite recent progress, locating multiple diffusion sources in time varying networks remains to be an outstanding problem. Bridging structural observability and sparse signal reconstruction theories, we develop a general framework to locate diffusion sources in time varying networks based solely on sparse data from a small set of messenger nodes. A general finding is that large degree nodes produce more valuable information than small degree nodes, a result that contrasts that for static networks. Choosing large degree nodes as the messengers, we find that sparse observations from a few such nodes are often sufficient for any number of diffusion sources to be located for a variety of model and empirical networks. Counterintuitively, sources in more rapidly varying networks can be identified more readily with fewer required messenger nodes.

Fixation of slightly beneficial mutations: effects of life history.

PubMed

Vindenes, Yngvild; Lee, Aline Magdalena; Engen, Steinar; Saether, Bernt-Erik

2010-04-01

Recent studies of rates of evolution have revealed large systematic differences among organisms with different life histories, both within and among taxa. Here, we consider how life history may affect the rate of evolution via its influence on the fixation probability of slightly beneficial mutations. Our approach is based on diffusion modeling for a finite, stage-structured population with stochastic population dynamics. The results, which are verified by computer simulations, demonstrate that even with complex population structure just two demographic parameters are sufficient to give an accurate approximation of the fixation probability of a slightly beneficial mutation. These are the reproductive value of the stage in which the mutation first occurs and the demographic variance of the population. The demographic variance also determines what influence population size has on the fixation probability. This model represents a substantial generalization of earlier models, covering a large range of life histories.

Implantable fluorescence-based glucose sensor development

NASA Astrophysics Data System (ADS)

Ibey, Bennett L.; Yadavalli, Vamsi K.; Thomas, Hope R.; Rounds, Rebecca M.; Pishko, Michael V.; Cote, Gerard L.

2005-03-01

An implantable sensor is being created that allows measurement of blood glucose through fluorescent detection of an embedded chemical assay. The sensor is based on the competitive binding reaction between the protein Concanavalin A and various saccharide molecules, specifically a glycodendrimer and glucose. Previous studies have shown the ability of an embedded chemical assay using Con A and dextran with shorter wavelength dyes to both sense changes in glucose and generate sufficient fluorescent emission to pass through the dermal tissue. However, due to the chemical constituents of the assay, multivalent binding was evident resulting in poor spectral change due to glucose within the biological range. Use of a glycodendrimer and longer wavelength dyes has improved the sensor"s spectral change due to glucose and the overall signal to noise ratio of the sensor. In this work, a description of this sensor and the results obtained from it will be presented showing a large dynamic range of fluorescence with glucose.

Simultaneous multi-species tracking in live cells with quantum dot conjugates.

PubMed

Clausen, Mathias P; Arnspang, Eva C; Ballou, Byron; Bear, James E; Lagerholm, B Christoffer

2014-01-01

Quantum dots are available in a range of spectrally separated emission colors and with a range of water-stabilizing surface coatings that offers great flexibility for enabling bio-specificity. In this study, we have taken advantage of this flexibility to demonstrate that it is possible to perform a simultaneous investigation of the lateral dynamics in the plasma membrane of i) the transmembrane epidermal growth factor receptor, ii) the glucosylphospatidylinositol-anchored protein CD59, and iii) ganglioside GM1-cholera toxin subunit B clusters in a single cell. We show that a large number of the trajectories are longer than 50 steps, which we by simulations show to be sufficient for robust single trajectory analysis. This analysis shows that the populations of the diffusion coefficients are heterogeneously distributed for all three species, but differ between the different species. We further show that the heterogeneity is decreased upon treating the cells with methyl-β-cyclodextrin.

Bennett ion mass spectrometers on the Pioneer Venus Bus and Orbiter

NASA Technical Reports Server (NTRS)

Taylor, H. A., Jr.; Brinton, H. C.; Wagner, T. C. G.; Blackwell, B. H.; Cordier, G. R.

1980-01-01

Identical Bennett radio-frequency ion mass spectrometer instruments on the Pioneer Venus Bus and Orbiter have provided the first in-situ measurements of the detailed composition of the planet's ionosphere. The sensitivity, resolution, and dynamic range are sufficient to provide measurements of the solar-wind-induced bow-shock, the ionopause, and highly structured distributions of up to 16 thermal ion species within the ionosphere. The use of adaptive scan and detection circuits and servo-controlled logic for ion mass and energy analysis permits detection of ion concentrations as low as 5 ions/cu cm and ion flow velocities as large as 9 km/sec for O(+). A variety of commandable modes provides ion sampling rates ranging from 0.1 to 1.6 sec between measurements of a single constituent. A lightweight sensor and electronics housing are features of a compact instrument package.

Continuous composition-spread thin films of transition metal oxides by pulsed-laser deposition

NASA Astrophysics Data System (ADS)

Ohkubo, I.; Christen, H. M.; Khalifah, P.; Sathyamurthy, S.; Zhai, H. Y.; Rouleau, C. M.; Mandrus, D. G.; Lowndes, D. H.

2004-02-01

We have designed an improved pulsed-laser deposition-continuous composition-spread (PLD-CCS) system that overcomes the difficulties associated with earlier related techniques. Our new PLD-CCS system is based on a precisely controlled synchronization between the laser firing, target exchange, and substrate translation/rotation, and offers more flexibility and control than earlier PLD-based approaches. Most importantly, the deposition energetics and the film thickness are kept constant across the entire composition range, and the resulting samples are sufficiently large to allow characterization by conventional techniques. We fabricated binary alloy composition-spread films composed of SrRuO 3 and CaRuO 3. Alternating ablation from two different ceramic targets leads to in situ alloy formation, and the value of x in Sr xCa x-1 RuO 3 can be changed linearly from 0 to 1 (or over any arbitrarily smaller range) along one direction of the substrate.

Antireflective surface with a step in the taper: Numerical optimization and large-area fabrication

NASA Astrophysics Data System (ADS)

Shinotsuka, Kei; Hongo, Koki; Dai, Kotaro; Hirama, Satoru; Hatta, Yoshihisa

2017-02-01

In this study, we developed a practical method to improve the optical performance of subwavelength antireflective two-dimensional (2D) gratings. A numerical simulation of both convex and concave paraboloids suggested that surface reflectivity drastically decreases when a step is introduced in the taper. The optimum height and depth of a step provided average reflectances of 0.098% for convex protrusions and 0.040% for concave protrusions in the visible range. Furthermore, a stepped paraboloid was experimentally fabricated by dry etching of a Si substrate with SiO2 particle monolayer mask. A cyclo-olefin polymer (COP) reverse replica (concave) imprinted by the Si mold exhibited a measured reflectance of 0.077% on average in the visible range. It was also demonstrated that the antireflective structure was fabricated on the whole surface of a 6 in. Si wafer, which is a sufficient size for industrial utilization.

Non-integral-spin bosonic excitations in untextured magnets

NASA Astrophysics Data System (ADS)

Kamra, Akashdeep; Agrawal, Utkarsh; Belzig, Wolfgang

Interactions are responsible for intriguing physics, e.g. emergence of exotic ground states and excitations, in a wide range of systems. Here we theoretically demonstrate that dipole-dipole interactions lead to bosonic eigen-excitations with spin ranging from zero to above ℏ in magnets with uniformly magnetized ground states. These exotic excitations can be interpreted as quantum coherent conglomerates of magnons, the eigen-excitations when the dipolar interactions are disregarded. We further find that the eigenmodes in an easy-axis antiferromagnet are spin-zero quasiparticles instead of the widely believed spin +/- ℏ magnons. The latter re-emerge when the symmetry is broken by a sufficiently large applied magnetic field. The spin greater than ℏ is accompanied by vacuum fluctuations and may be considered a weak form of frustration. We acknowledge financial support from the Alexander von Humboldt Foundation and the DFG through SFB 767.

The pulse profile of the Crab pulsar in the energy range 45 keV-1.2 MeV

NASA Technical Reports Server (NTRS)

Wilson, R. B.; Fishman, G. J.

1983-01-01

The Crab Nebula pulsar (PSR 0531+21) is the best studied and most intense of the nontransient X-ray pulsars. However, since its spectrum drops rapidly with energy, a well-resolved pulse profile has not previously been obtained above 200 keV. In the hard X-ray and low-energy gamma-ray region, an accurate pulse profile can be obtained with a balloon-borne detector of sufficient area during a single transit of the source. A new measurement of the pulse profile of PSR 0531+21 in the energy range above 45 keV obtained with a large-area scintillation detector array is reported. The detector array was flown on a balloon launched from Palestine, Texas on 1980 October 6, reaching a float altitude 4.5 g/sq cm at 0230 UTC October 7. The primary objective of the experiment was to detect and study weak gamma-ray bursts.

Polyimide/Carbon Nanotube Composite Films for Electrostatic Charge Mitigation

NASA Technical Reports Server (NTRS)

Smith, Joseph G., Jr.; Delozier, Donavon M.; Connell, John W.; Watson, Kent A.

2004-01-01

Low color, space environmentally durable polymeric films with sufficient electrical conductivity to mitigate electrostatic charge (ESC) build-up have potential applications on large, deployable, ultra-light weight Gossamer spacecraft as thin film membranes on antennas, solar sails, thermal/optical coatings, multi-layer insulation blankets, etc.. The challenge has been to develop a method to impart robust electrical conductivity into these materials without increasing solar absorptivity (alpha ) or decreasing optical transparency or film flexibility. Since these spacecraft will require significant compaction prior to launch, the film portion of the spacecraft will require folding. The state-of-the-art clear, conductive coating (e.g. indium-tin-oxide, ITO) is brittle and cannot tolerate folding. In this report, doping a polymer with single-walled carbon nanotubes (SWNTs) using two different methods afforded materials with good flexibility and surface conductivities in the range sufficient for ESC mitigation. A coating method afforded materials with minimal effects on the mechanical, optical, and thermo-optical properties as compared to dispersal of SWNTs in the matrix. The chemistry and physical properties of these nanocomposites are discussed.

Location of planar targets in three space from monocular images

NASA Technical Reports Server (NTRS)

Cornils, Karin; Goode, Plesent W.

1987-01-01

Many pieces of existing and proposed space hardware that would be targets of interest for a telerobot can be represented as planar or near-planar surfaces. Examples include the biostack modules on the Long Duration Exposure Facility, the panels on Solar Max, large diameter struts, and refueling receptacles. Robust and temporally efficient methods for locating such objects with sufficient accuracy are therefore worth developing. Two techniques that derive the orientation and location of an object from its monocular image are discussed and the results of experiments performed to determine translational and rotational accuracy are presented. Both the quadrangle projection and elastic matching techniques extract three-space information using a minimum of four identifiable target points and the principles of the perspective transformation. The selected points must describe a convex polygon whose geometric characteristics are prespecified in a data base. The rotational and translational accuracy of both techniques was tested at various ranges. This experiment is representative of the sensing requirements involved in a typical telerobot target acquisition task. Both techniques determined target location to an accuracy sufficient for consistent and efficient acquisition by the telerobot.

Detecting Thermal Cloaks via Transient Effects

PubMed Central

Sklan, Sophia R.; Bai, Xue; Li, Baowen; Zhang, Xiang

2016-01-01

Recent research on the development of a thermal cloak has concentrated on engineering an inhomogeneous thermal conductivity and an approximate, homogeneous volumetric heat capacity. While the perfect cloak of inhomogeneous κ and inhomogeneous ρcp is known to be exact (no signals scattering and only mean values penetrating to the cloak’s interior), the sensitivity of diffusive cloaks to defects and approximations has not been analyzed. We analytically demonstrate that these approximate cloaks are detectable. Although they work as perfect cloaks in the steady-state, their transient (time-dependent) response is imperfect and a small amount of heat is scattered. This is sufficient to determine the presence of a cloak and any heat source it contains, but the material composition hidden within the cloak is not detectable in practice. To demonstrate the feasibility of this technique, we constructed a cloak with similar approximation and directly detected its presence using these transient temperature deviations outside the cloak. Due to limitations in the range of experimentally accessible volumetric specific heats, our detection scheme should allow us to find any realizable cloak, assuming a sufficiently large temperature difference. PMID:27605153

Acquisition and tracking for underwater optical communications

NASA Astrophysics Data System (ADS)

Williams, Andrew J.; Laycock, Leslie L.; Griffith, Michael S.; McCarthy, Andrew G.; Rowe, Duncan P.

2017-10-01

There is a growing requirement to transfer large volumes of data between underwater platforms. As seawater is transmissive in the visible band, underwater optical communications is an active area of interest since it offers the potential for power efficient, covert and high bandwidth datalinks at short to medium ranges. Short range systems have been successfully demonstrated using sources with low directionality. To realise higher data rates and/or longer ranges, the use of more efficient directional beams is required; by necessity, these must be sufficiently aligned to achieve the required link margin. For mobile platforms, the acquisition and tracking of each node is therefore critical in order to establish and maintain an optical datalink. This paper describes work undertaken to demonstrate acquisition and tracking in a 3D underwater environment. A range of optical sources, beam steering technologies, and tracking sensors have been assessed for suitability. A novel scanning strategy exploiting variable beam divergence was developed to provide robust acquisition whilst minimising acquisition time. A prototype system was assembled and demonstrated in a large water tank. This utilised custom quadrant detectors based on Silicon PhotoMultiplier (SiPM) arrays for fine tracking, and a Wide Field of View (WFoV) sCMOS camera for link acquisition. Fluidic lenses provided dynamic control of beam divergence, and AC modulation/filtering enabled background rejection. The system successfully demonstrated robust optical acquisition and tracking between two nodes with only nanowatt received optical powers. The acquisition time was shown to be dependent on the initial conditions and the transmitted optical power.

Phased Array-Fed Reflector (PAFR) Antenna Architectures for Space-Based Sensors

NASA Technical Reports Server (NTRS)

Cooley, Michael E.

2014-01-01

Communication link and target ranges for satellite communications (SATCOM) and space-based sensors (e.g. radars) vary from approximately 1000 km (for LEO satellites) to 35,800 km (for GEO satellites). At these long ranges, large antenna gains are required and legacy payloads have usually employed large reflectors with single beams that are either fixed or mechanically steered. For many applications, there are inherent limitations that are associated with the use of these legacy antennas/payloads. Hybrid antenna designs using Phased Array Fed Reflectors (PAFRs) provide a compromise between reflectors and Direct Radiating phased Arrays (DRAs). PAFRs provide many of the performance benefits of DRAs while utilizing much smaller, lower cost (feed) arrays. The primary limitation associated with hybrid PAFR architectures is electronic scan range; approximately +/-5 to +/- 10 degrees is typical, but this range depends on many factors. For LEO applications, the earth FOV is approximately +/-55 degrees which is well beyond the range of electronic scanning for PAFRs. However, for some LEO missions, limited scanning is sufficient or the CONOPS and space vehicle designs can be developed to incorporate a combination mechanical slewing and electronic scanning. In this paper, we review, compare and contrast various PAFR architectures with a focus on their general applicability to space missions. We compare the RF performance of various PAFR architectures and describe key hardware design and implementation trades. Space-based PAFR designs are highly multi-disciplinary and we briefly address key hardware engineering design areas. Finally, we briefly describe two PAFR antenna architectures that have been developed at Northrop Grumman.

Adding the missing piece: Spitzer imaging of the HSC-Deep/PFS fields

NASA Astrophysics Data System (ADS)

Sajina, Anna; Bezanson, Rachel; Capak, Peter; Egami, Eiichi; Fan, Xiaohui; Farrah, Duncan; Greene, Jenny; Goulding, Andy; Lacy, Mark; Lin, Yen-Ting; Liu, Xin; Marchesini, Danilo; Moutard, Thibaud; Ono, Yoshiaki; Ouchi, Masami; Sawicki, Marcin; Strauss, Michael; Surace, Jason; Whitaker, Katherine

2018-05-01

We propose to observe a total of 7sq.deg. to complete the Spitzer-IRAC coverage of the HSC-Deep survey fields. These fields are the sites of the PrimeFocusSpectrograph (PFS) galaxy evolution survey which will provide spectra of wide wavelength range and resolution for almost all M* galaxies at z 0.7-1.7, and extend out to z 7 for targeted samples. Our fields already have deep broadband and narrowband photometry in 12 bands spanning from u through K and a wealth of other ancillary data. We propose completing the matching depth IRAC observations in the extended COSMOS, ELAIS-N1 and Deep2-3 fields. By complementing existing Spitzer coverage, this program will lead to an unprecedended in spectro-photometric coverage dataset across a total of 15 sq.deg. This dataset will have significant legacy value as it samples a large enough cosmic volume to be representative of the full range of environments, but also doing so with sufficient information content per galaxy to confidently derive stellar population characteristics. This enables detailed studies of the growth and quenching of galaxies and their supermassive black holes in the context of a galaxy's local and large scale environment.

Estimating Eulerian spectra from pairs of drifters

NASA Astrophysics Data System (ADS)

LaCasce, Joe

2017-04-01

GPS-tracked surface drifters offer the possibility of sampling energetic variations at the ocean surface on scales of only 10s of meters, much less than that resolved by satellite. Here we investigate whether velocity differences between pairs of drifters can be used to estimate kinetic energy spectra. Theoretical relations between the spectrum and the second-order longitudinal structure function for 2D non-divergent flow are derived. The structure function is a natural statistic for particle pairs and is easily calculated. However it integrates contributions across wavenumber, and this tends to obscure the spectral dependencies when turbulent inertial ranges are of finite extent. Nevertheless, the transform from spectrum to structure function is robust, as illustrated with Eulerian data collected from aircraft. The inverse transform, from structure function to spectrum, is much less robust, yielding poor results in particular at large wavenumbers. This occurs because the transform involves a filter function which magnifies contributions from large pair separations, which tend to be noisy. Fitting the structure function to a polynomial improves the spectral estimate, but not sufficiently to distinguish correct inertial range dependencies. Thus with Lagrangian data, it is appears preferable to focus on structure functions, despite their shortcomings.

Re-evaluating the link between brain size and behavioural ecology in primates.

PubMed

Powell, Lauren E; Isler, Karin; Barton, Robert A

2017-10-25

Comparative studies have identified a wide range of behavioural and ecological correlates of relative brain size, with results differing between taxonomic groups, and even within them. In primates for example, recent studies contradict one another over whether social or ecological factors are critical. A basic assumption of such studies is that with sufficiently large samples and appropriate analysis, robust correlations indicative of selection pressures on cognition will emerge. We carried out a comprehensive re-examination of correlates of primate brain size using two large comparative datasets and phylogenetic comparative methods. We found evidence in both datasets for associations between brain size and ecological variables (home range size, diet and activity period), but little evidence for an effect of social group size, a correlation which has previously formed the empirical basis of the Social Brain Hypothesis. However, reflecting divergent results in the literature, our results exhibited instability across datasets, even when they were matched for species composition and predictor variables. We identify several potential empirical and theoretical difficulties underlying this instability and suggest that these issues raise doubts about inferring cognitive selection pressures from behavioural correlates of brain size. © 2017 The Author(s).

Oblique nonlinear whistler wave

NASA Astrophysics Data System (ADS)

Yoon, Peter H.; Pandey, Vinay S.; Lee, Dong-Hun

2014-03-01

Motivated by satellite observation of large-amplitude whistler waves propagating in oblique directions with respect to the ambient magnetic field, a recent letter discusses the physics of large-amplitude whistler waves and relativistic electron acceleration. One of the conclusions of that letter is that oblique whistler waves will eventually undergo nonlinear steepening regardless of the amplitude. The present paper reexamines this claim and finds that the steepening associated with the density perturbation almost never occurs, unless whistler waves have sufficiently high amplitude and propagate sufficiently close to the resonance cone angle.

Parameterization of a ruminant model of phosphorus digestion and metabolism.

PubMed

Feng, X; Knowlton, K F; Hanigan, M D

2015-10-01

The objective of the current work was to parameterize the digestive elements of the model of Hill et al. (2008) using data collected from animals that were ruminally, duodenally, and ileally cannulated, thereby providing a better understanding of the digestion and metabolism of P fractions in growing and lactating cattle. The model of Hill et al. (2008) was fitted and evaluated for adequacy using the data from 6 animal studies. We hypothesized that sufficient data would be available to estimate P digestion and metabolism parameters and that these parameters would be sufficient to derive P bioavailabilities of a range of feed ingredients. Inputs to the model were dry matter intake; total feed P concentration (fPtFd); phytate (Pp), organic (Po), and inorganic (Pi) P as fractions of total P (fPpPt, fPoPt, fPiPt); microbial growth; amount of Pi and Pp infused into the omasum or ileum; milk yield; and BW. The available data were sufficient to derive all model parameters of interest. The final model predicted that given 75 g/d of total P input, the total-tract digestibility of P was 40.8%, Pp digestibility in the rumen was 92.4%, and in the total-tract was 94.7%. Blood P recycling to the rumen was a major source of Pi flow into the small intestine, and the primary route of excretion. A large proportion of Pi flowing to the small intestine was absorbed; however, additional Pi was absorbed from the large intestine (3.15%). Absorption of Pi from the small intestine was regulated, and given the large flux of salivary P recycling, the effective fractional small intestine absorption of available P derived from the diet was 41.6% at requirements. Milk synthesis used 16% of total absorbed P, and less than 1% was excreted in urine. The resulting model could be used to derive P bioavailabilities of commonly used feedstuffs in cattle production. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

The stability of the stratospheric ozone layer during the end-Permian eruption of the Siberian Traps.

PubMed

Beerling, David J; Harfoot, Michael; Lomax, Barry; Pyle, John A

2007-07-15

The discovery of mutated palynomorphs in end-Permian rocks led to the hypothesis that the eruption of the Siberian Traps through older organic-rich sediments synthesized and released massive quantities of organohalogens, which caused widespread O3 depletion and allowed increased terrestrial incidence of harmful ultraviolet-B radiation (UV-B, 280-315nm; Visscher et al. 2004 Proc. Natl Acad. Sci. USA 101, 12952-12956). Here, we use an extended version of the Cambridge two-dimensional chemistry-transport model to evaluate quantitatively this possibility along with two other potential causes of O3 loss at this time: (i) direct effects of HCl release by the Siberian Traps and (ii) the indirect release of organohalogens from dispersed organic matter. According to our simulations, CH3Cl released from the heating of coals alone caused comparatively minor O3 depletion (5-20% maximum) because this mechanism fails to deliver sufficiently large amounts of Cl into the stratosphere. The unusual explosive nature of the Siberian Traps, combined with the direct release of large quantities of HCl, depleted the model O3 layer in the high northern latitudes by 33-55%, given a main eruptive phase of less than or equal to 200kyr. Nevertheless, O3 depletion was most extensive when HCl release from the Siberian Traps was combined with massive CH3Cl release synthesized from a large reservoir of dispersed organic matter in Siberian rocks. This suite of model experiments produced column O3 depletion of 70-85% and 55-80% in the high northern and southern latitudes, respectively, given eruption durations of 100-200kyr. On longer eruption time scales of 400-600kyr, corresponding O3 depletion was 30-40% and 20-30%, respectively. Calculated year-round increases in total near-surface biologically effective (BE) UV-B radiation following these reductions in O3 layer range from 30-60 (kJm(-2)d(-1))BE up to 50-100 (kJm(-2)d(-1))BE. These ranges of daily UV-B doses appear sufficient to exert mutagenic effects on plants, especially if sustained over tens of thousands of years, unlike either rising temperatures or SO2 concentrations.

Transfer, loss and physical processing of water in hit-and-run collisions of planetary embryos

NASA Astrophysics Data System (ADS)

Burger, C.; Maindl, T. I.; Schäfer, C. M.

2018-01-01

Collisions between large, similar-sized bodies are believed to shape the final characteristics and composition of terrestrial planets. Their inventories of volatiles such as water are either delivered or at least significantly modified by such events. Besides the transition from accretion to erosion with increasing impact velocity, similar-sized collisions can also result in hit-and-run outcomes for sufficiently oblique impact angles and large enough projectile-to-target mass ratios. We study volatile transfer and loss focusing on hit-and-run encounters by means of smooth particle hydrodynamics simulations, including all main parameters: impact velocity, impact angle, mass ratio and also the total colliding mass. We find a broad range of overall water losses, up to 75% in the most energetic hit-and-run events, and confirm the much more severe consequences for the smaller body also for stripping of volatile layers. Transfer of water between projectile and target inventories is found to be mostly rather inefficient, and final water contents are dominated by pre-collision inventories reduced by impact losses, for similar pre-collision water mass fractions. Comparison with our numerical results shows that current collision outcome models are not accurate enough to reliably predict these composition changes in hit-and-run events. To also account for non-mechanical losses, we estimate the amount of collisionally vaporized water over a broad range of masses and find that these contributions are particularly important in collisions of ˜ Mars-sized bodies, with sufficiently high impact energies, but still relatively low gravity. Our results clearly indicate that the cumulative effect of several (hit-and-run) collisions can efficiently strip protoplanets of their volatile layers, especially the smaller body, as it might be common, e.g., for Earth-mass planets in systems with Super-Earths. An accurate model for stripping of volatiles that can be included in future planet formation simulations has to account for the peculiarities of hit-and-run events and track compositional changes in both large post-collision fragments.

Ice-Accretion Test Results for Three Large-Scale Swept-Wing Models in the NASA Icing Research Tunnel

NASA Technical Reports Server (NTRS)

Broeren, Andy P.; Potapczuk, Mark G.; Lee, Sam; Malone, Adam M.; Paul, Benard P., Jr.; Woodard, Brian S.

2016-01-01

Icing simulation tools and computational fluid dynamics codes are reaching levels of maturity such that they are being proposed by manufacturers for use in certification of aircraft for flight in icing conditions with increasingly less reliance on natural-icing flight testing and icing-wind-tunnel testing. Sufficient high-quality data to evaluate the performance of these tools is not currently available. The objective of this work was to generate a database of ice-accretion geometry that can be used for development and validation of icing simulation tools as well as for aerodynamic testing. Three large-scale swept wing models were built and tested at the NASA Glenn Icing Research Tunnel (IRT). The models represented the Inboard (20% semispan), Midspan (64% semispan) and Outboard stations (83% semispan) of a wing based upon a 65% scale version of the Common Research Model (CRM). The IRT models utilized a hybrid design that maintained the full-scale leading-edge geometry with a truncated afterbody and flap. The models were instrumented with surface pressure taps in order to acquire sufficient aerodynamic data to verify the hybrid model design capability to simulate the full-scale wing section. A series of ice-accretion tests were conducted over a range of total temperatures from -23.8 deg C to -1.4 deg C with all other conditions held constant. The results showed the changing ice-accretion morphology from rime ice at the colder temperatures to highly 3-D scallop ice in the range of -11.2 deg C to -6.3 deg C. Warmer temperatures generated highly 3-D ice accretion with glaze ice characteristics. The results indicated that the general scallop ice morphology was similar for all three models. Icing results were documented for limited parametric variations in angle of attack, drop size and cloud liquid-water content (LWC). The effect of velocity on ice accretion was documented for the Midspan and Outboard models for a limited number of test cases. The data suggest that there are morphological characteristics of glaze and scallop ice accretion on these swept-wing models that are dependent upon the velocity. This work has resulted in a large database of ice-accretion geometry on large-scale, swept-wing models.

Ice-Accretion Test Results for Three Large-Scale Swept-Wing Models in the NASA Icing Research Tunnel

NASA Technical Reports Server (NTRS)

Broeren, Andy P.; Potapczuk, Mark G.; Lee, Sam; Malone, Adam M.; Paul, Bernard P., Jr.; Woodard, Brian S.

2016-01-01

Icing simulation tools and computational fluid dynamics codes are reaching levels of maturity such that they are being proposed by manufacturers for use in certification of aircraft for flight in icing conditions with increasingly less reliance on natural-icing flight testing and icing-wind-tunnel testing. Sufficient high-quality data to evaluate the performance of these tools is not currently available. The objective of this work was to generate a database of ice-accretion geometry that can be used for development and validation of icing simulation tools as well as for aerodynamic testing. Three large-scale swept wing models were built and tested at the NASA Glenn Icing Research Tunnel (IRT). The models represented the Inboard (20 percent semispan), Midspan (64 percent semispan) and Outboard stations (83 percent semispan) of a wing based upon a 65 percent scale version of the Common Research Model (CRM). The IRT models utilized a hybrid design that maintained the full-scale leading-edge geometry with a truncated afterbody and flap. The models were instrumented with surface pressure taps in order to acquire sufficient aerodynamic data to verify the hybrid model design capability to simulate the full-scale wing section. A series of ice-accretion tests were conducted over a range of total temperatures from -23.8 to -1.4 C with all other conditions held constant. The results showed the changing ice-accretion morphology from rime ice at the colder temperatures to highly 3-D scallop ice in the range of -11.2 to -6.3 C. Warmer temperatures generated highly 3-D ice accretion with glaze ice characteristics. The results indicated that the general scallop ice morphology was similar for all three models. Icing results were documented for limited parametric variations in angle of attack, drop size and cloud liquid-water content (LWC). The effect of velocity on ice accretion was documented for the Midspan and Outboard models for a limited number of test cases. The data suggest that there are morphological characteristics of glaze and scallop ice accretion on these swept-wing models that are dependent upon the velocity. This work has resulted in a large database of ice-accretion geometry on large-scale, swept-wing models.

Method for creating high carbon content products from biomass oil

DOEpatents

Parker, Reginald; Seames, Wayne

2012-12-18

In a method for producing high carbon content products from biomass, a biomass oil is added to a cracking reactor vessel. The biomass oil is heated to a temperature ranging from about 100.degree. C. to about 800.degree. C. at a pressure ranging from about vacuum conditions to about 20,700 kPa for a time sufficient to crack the biomass oil. Tar is separated from the cracked biomass oil. The tar is heated to a temperature ranging from about 200.degree. C. to about 1500.degree. C. at a pressure ranging from about vacuum conditions to about 20,700 kPa for a time sufficient to reduce the tar to a high carbon content product containing at least about 50% carbon by weight.

Assisted colonization is not a viable conservation strategy.

PubMed

Ricciardi, Anthony; Simberloff, Daniel

2009-05-01

A potential conservation strategy increasingly discussed by conservation biologists is the translocation of species to favorable habitat beyond their native range to protect them from human-induced threats, such as climate change. Even if preceded by careful risk assessment, such action is likely to produce myriad unintended and unpredictable consequences. Accurate risk assessment is impeded by contingency: the impacts of introduced species vary over time and space under the influence of local environmental variables, interspecific interactions and evolutionary change. Some impacts, such as native species extinctions, are large and irrevocable. Here we argue that conservation biologists have not yet developed a sufficient understanding of the impacts of introduced species to make informed decisions regarding species translocations.

Development of techniques for advanced optical contamination measurement with internal reflection spectroscopy, phase 1, volume 1

NASA Technical Reports Server (NTRS)

Hayes, J. D.

1972-01-01

The feasibility of monitoring volatile contaminants in a large space simulation chamber using techniques of internal reflection spectroscopy was demonstrated analytically and experimentally. The infrared spectral region was selected as the operational spectral range in order to provide unique identification of the contaminants along with sufficient sensitivity to detect trace contaminant concentrations. It was determined theoretically that a monolayer of the contaminants could be detected and identified using optimized experimental procedures. This ability was verified experimentally. Procedures were developed to correct the attenuated total reflectance spectra for thick sample distortion. However, by using two different element designs the need for such correction can be avoided.

Aging transition in systems of oscillators with global distributed-delay coupling.

PubMed

Rahman, B; Blyuss, K B; Kyrychko, Y N

2017-09-01

We consider a globally coupled network of active (oscillatory) and inactive (nonoscillatory) oscillators with distributed-delay coupling. Conditions for aging transition, associated with suppression of oscillations, are derived for uniform and gamma delay distributions in terms of coupling parameters and the proportion of inactive oscillators. The results suggest that for the uniform distribution increasing the width of distribution for the same mean delay allows aging transition to happen for a smaller coupling strength and a smaller proportion of inactive elements. For gamma distribution with sufficiently large mean time delay, it may be possible to achieve aging transition for an arbitrary proportion of inactive oscillators, as long as the coupling strength lies in a certain range.

Geology and hydrology for environmental planning in Marquette County, Michigan

USGS Publications Warehouse

Twenter, F.R.

1981-01-01

Marquette County, in the glaciated area of the Upper Peninsula of Michigan, includes 1,878 square miles. Precipitation averages 32 inches per year. Bedrock and glacial deposits contain materials that are good aquifers. Sedimentary bedrock units generally yield sufficient water for domestic supply and, in places, may yield more than 100 gallons per minute to large-diameter wells. In the glacial deposits, sand and gravel beds are the principal aquifers; yields to wells range from less than 10 to 200 gallons per minute. Igneous and metamorphic rocks yield little or no water to wells. Suitable sewage and refuse disposal sites are not readily available because of the abundance of wetlands, streams, and lakes susceptible to infiltrating leachate.

ARC-1989-AC89-7032

NASA Image and Video Library

1989-08-24

Range : 530,000 km (330,000 mi.) This color photo of Neptune's large satellite Triton has a resolution of about 10 km (6.2 mi), sufficient to begin to show topographic detail. The image was made from pictures taken through the green, violet and ultraviolet filters. In this technique, regions that are highly reflective in the ultraviolet appear blue in color. In reality, there is no part of Triton that would appear blue to the eye. The bright southern hemisphere of Triton, which fills most of this frame, is generally pink in tone as is the even brighter equatorial band. The darker regions north of the equator also tend to be pink or reddish in color.

Free-style Deepithelialized Propeller Flaps: An Ideal Local Flap to Obliterate Wounds with Dead Space.

PubMed

Datli, Asli; Suh, HyunSuk; Kim, Young Chul; Choi, Doon Hoon; Hong, Joon Pio Jp

2017-03-01

The reconstruction of the posterior trunk, especially with large dead spaces, remains challenging. Regional muscle flaps may lack adequate volume and reach. The purpose of this report was to evaluate the efficacy of deepithelialized free-style perforator-based propeller flaps to obliterate defects with large dead space. A total of 7 patients with defects on the posterior trunk with large dead spaces were evaluated. After complete debridement or resection, all flaps were designed on a single perforator adjacent to the defect, deepithelialized, and then rotated in a propeller fashion. Flaps were further modified in some cases such as folding the flap after deepithelialization to increase bulk and to obliterate the dead space. The flap dimension ranged from 10 × 5 × 1 to 15 × 8 × 2.5 cm based on a single perforator. The rotation arch of the flap ranged from 90 to 180 degrees. Uneventful healing was noted in all cases. One case showed latent redness and swelling at 7 months after falling down, which resolved with medication. During the average follow-up of 28 months, there were no other flap and donor site complications. The deepithelialized propeller flap can be used efficiently to obliterate dead spaces in the posterior trunk and retains advantages such as having a good vascular supply, adequate bulk, sufficient reach without tension, and minimal donor site morbidity.

Energy Return on Investment (EROI) for Forty Global Oilfields Using a Detailed Engineering-Based Model of Oil Production.

PubMed

Brandt, Adam R; Sun, Yuchi; Bharadwaj, Sharad; Livingston, David; Tan, Eugene; Gordon, Deborah

2015-01-01

Studies of the energy return on investment (EROI) for oil production generally rely on aggregated statistics for large regions or countries. In order to better understand the drivers of the energy productivity of oil production, we use a novel approach that applies a detailed field-level engineering model of oil and gas production to estimate energy requirements of drilling, producing, processing, and transporting crude oil. We examine 40 global oilfields, utilizing detailed data for each field from hundreds of technical and scientific data sources. Resulting net energy return (NER) ratios for studied oil fields range from ≈2 to ≈100 MJ crude oil produced per MJ of total fuels consumed. External energy return (EER) ratios, which compare energy produced to energy consumed from external sources, exceed 1000:1 for fields that are largely self-sufficient. The lowest energy returns are found to come from thermally-enhanced oil recovery technologies. Results are generally insensitive to reasonable ranges of assumptions explored in sensitivity analysis. Fields with very large associated gas production are sensitive to assumptions about surface fluids processing due to the shifts in energy consumed under different gas treatment configurations. This model does not currently include energy invested in building oilfield capital equipment (e.g., drilling rigs), nor does it include other indirect energy uses such as labor or services.

Long-range single domain array of a 5 nm pattern of supramolecules via solvent annealing in a double-sandwich cell.

PubMed

Kwon, Kiok; Park, Kangho; Jung, Hee-Tae

2018-05-10

In nanotechnology and microelectronics research, the generation of an ultradense, single-grain nanostructure with a long-range lateral order is challenging. In this paper, we report upon a new solvent-annealing method using a double-sandwich confinement to promote the formation of a large-area, single-domain array (>0.3 × 0.3 mm2) of supramolecular cylinders with a small feature size (4.7 nm). The in situ GISAXS experiment result shows the ordering process during solvent evaporation. The diffusion of the solvent molecules led to the disassembly of the supramolecules confined between the top and bottom surfaces and their subsequent mobilization, thereby producing a highly ordered hexagonal array of supramolecular materials under the double-sandwich confinement upon solvent evaporation. In addition, two key factors were found to be crucial in this process for generating highly-ordered supramolecular building blocks: (i) the presence of a top coat during solvent evaporation to provide a geometric confinement template, and (ii) the control of the solvent evaporation rate during the solvent evaporation step to provide the dendrimer sufficient time to self-assemble into the highly ordered state over a large area. Our developed approach, which can be extended to be used for a large family of supramolecules, is of critical importance in providing a new bottom-up lithographic method based on supramolecular self-assembly.

Energy Return on Investment (EROI) for Forty Global Oilfields Using a Detailed Engineering-Based Model of Oil Production

PubMed Central

Brandt, Adam R.; Sun, Yuchi; Bharadwaj, Sharad; Livingston, David; Tan, Eugene; Gordon, Deborah

2015-01-01

Studies of the energy return on investment (EROI) for oil production generally rely on aggregated statistics for large regions or countries. In order to better understand the drivers of the energy productivity of oil production, we use a novel approach that applies a detailed field-level engineering model of oil and gas production to estimate energy requirements of drilling, producing, processing, and transporting crude oil. We examine 40 global oilfields, utilizing detailed data for each field from hundreds of technical and scientific data sources. Resulting net energy return (NER) ratios for studied oil fields range from ≈2 to ≈100 MJ crude oil produced per MJ of total fuels consumed. External energy return (EER) ratios, which compare energy produced to energy consumed from external sources, exceed 1000:1 for fields that are largely self-sufficient. The lowest energy returns are found to come from thermally-enhanced oil recovery technologies. Results are generally insensitive to reasonable ranges of assumptions explored in sensitivity analysis. Fields with very large associated gas production are sensitive to assumptions about surface fluids processing due to the shifts in energy consumed under different gas treatment configurations. This model does not currently include energy invested in building oilfield capital equipment (e.g., drilling rigs), nor does it include other indirect energy uses such as labor or services. PMID:26695068

New collector efficiency equation for colloid filtration in both natural and engineered flow conditions

NASA Astrophysics Data System (ADS)

Nelson, Kirk E.; Ginn, Timothy R.

2011-05-01

A new equation for the collector efficiency (η) of the colloid filtration theory (CFT) is developed via nonlinear regression on the numerical data generated by a large number of Lagrangian simulations conducted in Happel's sphere-in-cell porous media model over a wide range of environmentally relevant conditions. The new equation expands the range of CFT's applicability in the natural subsurface primarily by accommodating departures from power law dependence of η on the Peclet and gravity numbers, a necessary but as of yet unavailable feature for applying CFT to large-scale field transport (e.g., of nanoparticles, radionuclides, or genetically modified organisms) under low groundwater velocity conditions. The new equation also departs from prior equations for colloids in the nanoparticle size range at all fluid velocities. These departures are particularly relevant to subsurface colloid and colloid-facilitated transport where low permeabilities and/or hydraulic gradients lead to low groundwater velocities and/or to nanoparticle fate and transport in porous media in general. We also note the importance of consistency in the conceptualization of particle flux through the single collector model on which most η equations are based for the purpose of attaining a mechanistic understanding of the transport and attachment steps of deposition. A lack of sufficient data for small particles and low velocities warrants further experiments to draw more definitive and comprehensive conclusions regarding the most significant discrepancies between the available equations.

Formation and relaxation of quasistationary states in particle systems with power-law interactions

NASA Astrophysics Data System (ADS)

Marcos, B.; Gabrielli, A.; Joyce, M.

2017-09-01

We explore the formation and relaxation of the so-called quasistationary states (QSS) for particle distributions in three dimensions interacting via an attractive radial pair potential V (r →∞ ) ˜1 /rγ with γ >0 , and either a soft core or hard core regularization at small r . In the first part of the paper, we generalize, for any spatial dimension d ≥2 , Chandrasekhar's approach for the case of gravity to obtain analytic estimates of the rate of collisional relaxation due to two-body collisions. The resultant relaxation rates indicate an essential qualitative difference depending on the integrability of the pair force at large distances: for γ >d -1 , the rate diverges in the large particle number N (mean-field) limit, unless a sufficiently large soft core is present; for γ

Compressible turbulent mixing: Effects of Schmidt number.

PubMed

Ni, Qionglin

2015-05-01

We investigated by numerical simulations the effects of Schmidt number on passive scalar transport in forced compressible turbulence. The range of Schmidt number (Sc) was 1/25∼25. In the inertial-convective range the scalar spectrum seemed to obey the k(-5/3) power law. For Sc≫1, there appeared a k(-1) power law in the viscous-convective range, while for Sc≪1, a k(-17/3) power law was identified in the inertial-diffusive range. The scaling constant computed by the mixed third-order structure function of the velocity-scalar increment showed that it grew over Sc, and the effect of compressibility made it smaller than the 4/3 value from incompressible turbulence. At small amplitudes, the probability distribution function (PDF) of scalar fluctuations collapsed to the Gaussian distribution whereas, at large amplitudes, it decayed more quickly than Gaussian. At large scales, the PDF of scalar increment behaved similarly to that of scalar fluctuation. In contrast, at small scales it resembled the PDF of scalar gradient. Furthermore, the scalar dissipation occurring at large magnitudes was found to grow with Sc. Due to low molecular diffusivity, in the Sc≫1 flow the scalar field rolled up and got mixed sufficiently. However, in the Sc≪1 flow the scalar field lost the small-scale structures by high molecular diffusivity and retained only the large-scale, cloudlike structures. The spectral analysis found that the spectral densities of scalar advection and dissipation in both Sc≫1 and Sc≪1 flows probably followed the k(-5/3) scaling. This indicated that in compressible turbulence the processes of advection and dissipation except that of scalar-dilatation coupling might deferring to the Kolmogorov picture. It then showed that at high wave numbers, the magnitudes of spectral coherency in both Sc≫1 and Sc≪1 flows decayed faster than the theoretical prediction of k(-2/3) for incompressible flows. Finally, the comparison with incompressible results showed that the scalar in compressible turbulence with Sc=1 lacked a conspicuous bump structure in its spectrum, but was more intermittent in the dissipative range.

Assessing sufficiency of thermal riverscapes for resilient ...

EPA Pesticide Factsheets

Resilient salmon populations require river networks that provide water temperature regimes sufficient to support a diversity of salmonid life histories across space and time. Efforts to protect, enhance and restore watershed thermal regimes for salmon may target specific locations and features within stream networks hypothesized to provide disproportionately high-value functional resilience to salmon populations. These include relatively small-scale features such as thermal refuges, and larger-scale features such as entire watersheds or aquifers that support thermal regimes buffered from local climatic conditions. Quantifying the value of both small and large scale thermal features to salmon populations has been challenged by both the difficulty of mapping thermal regimes at sufficient spatial and temporal resolutions, and integrating thermal regimes into population models. We attempt to address these challenges by using newly-available datasets and modeling approaches to link thermal regimes to salmon populations across scales. We will describe an individual-based modeling approach for assessing sufficiency of thermal refuges for migrating salmon and steelhead in large rivers, as well as a population modeling approach for assessing large-scale climate refugia for salmon in the Pacific Northwest. Many rivers and streams in the Pacific Northwest are currently listed as impaired under the Clean Water Act as a result of high summer water temperatures. Adverse effec

Electrohydrodynamically driven large-area liquid ion sources

DOEpatents

Pregenzer, Arian L.

1988-01-01

A large-area liquid ion source comprises means for generating, over a large area of the surface of a liquid, an electric field of a strength sufficient to induce emission of ions from a large area of said liquid. Large areas in this context are those distinct from emitting areas in unidimensional emitters.

A review of population-based prevalence studies of physical activity in adults in the Asia-Pacific region

PubMed Central

2012-01-01

Background Physical activity (PA) surveillance is an important component of non-communicable disease risk factor monitoring, and occurs through national and international surveillance systems. This review identifies population PA estimates for adults in the Asia-Pacific region, and examines variation in trends and prevalence rates obtained using different PA measures. Methods Data were obtained from a MEDLINE search; World Health Organization's Global Health Infobase; Government websites and reference lists of relevant papers. Inclusion criteria included: national studies or those reporting large scale population-level data; data published from 2000 to 2010 and trend data prior; sample sizes over n = 1000, or fewer subjects in small nations. Results In total, 56 population surveys from 29 Asia-Pacific countries were identified. Data on 'sufficient physical activity' amongst adults were available from 45 studies (80%), with estimates ranging from 7% to 93% (median 62%, inter-quartile range 40%-85%). For 14 countries, estimates of 'sufficient activity' were documented in multiple surveys using different methods, with the largest variation from 18% to 92% in Nepal. Median or mean MET-minutes/day, reported in 20 studies, ranged from 6 to 1356. Serial trend data were available for 11 countries (22%), for periods spanning 2-10 years. Of these, five countries demonstrated increases in physical activity over time, four demonstrated decreases and three showed no changes. Conclusions Many countries in the Asia-Pacific region collect population-level PA data. This review highlights differences in estimates within and between countries. Some differences may be real, others due to variation in the PA questions asked and survey methods used. Use of standardized protocols and measures, and combined reporting of data are essential goals of improved international PA surveillance. PMID:22251660

Distant and Regional Atmospheric Circulation Influences Governing Integrated Water Vapor Transport and the Occurrence of Extreme Precipitation Events

NASA Astrophysics Data System (ADS)

Bosart, L. F.; Papin, P. P.; Bentley, A. M.

2017-12-01

This presentation will show how the evolution of the large-scale and regional-scale atmospheric circulation contributes to the occurrence of extreme precipitation events (EPEs). An EPE requires that tropospheric moisture flux convergence (MFC) and the associated removal of hydrometeors be balanced by moisture replenishment via integrated (water) vapor transport (IVT) to continuously replenish condensed moisture. Moisture source regions may be distant or regional. Distant moisture sources may require the interaction of lower- and upper-level jet streams with a pre-existing mobile atmospheric disturbance to produce sufficient lift to condense moisture. Pre-existing regional moisture sources may require frontal lifting the presence of MFC to condense moisture. In cases of long-range IVT, such as moisture from a western North Pacific typhoon being drawn poleward along an atmospheric river (AR) toward the west coast of North America, moisture may be transported 1000s of kilometers along a low-level jet before a combination of dynamic and orographic lift results in an EPE. Alternatively, in the case of a typical summer warm and humid air mass over the continental United States, unused moisture may exist for several days in this air mass before sufficient MFC associated with a thermally direct mesoscale frontal circulation can concentrate and condense the moisture. In this case, there may be no long-range IVT via ARs. Instead, the atmospheric circulations may evolve to produce sustained MFC associated with mesoscale frontal circulations, especially in the presence of complex terrain, to produce an EPE. During this presentation, examples of EPEs associated with long-range IVT and distant MFC versus EPEs associated with regional MFC and mesoscale frontal circulations will be illustrated.

Systematic deficiency of aftershocks in areas of high coseismic slip for large subduction zone earthquakes

PubMed Central

Wetzler, Nadav; Lay, Thorne; Brodsky, Emily E.; Kanamori, Hiroo

2018-01-01

Fault slip during plate boundary earthquakes releases a portion of the shear stress accumulated due to frictional resistance to relative plate motions. Investigation of 101 large [moment magnitude (Mw) ≥ 7] subduction zone plate boundary mainshocks with consistently determined coseismic slip distributions establishes that 15 to 55% of all master event–relocated aftershocks with Mw ≥ 5.2 are located within the slip regions of the mainshock ruptures and few are located in peak slip regions, allowing for uncertainty in the slip models. For the preferred models, cumulative deficiency of aftershocks within the central three-quarters of the scaled slip regions ranges from 15 to 45%, increasing with the total number of observed aftershocks. The spatial gradients of the mainshock coseismic slip concentrate residual shear stress near the slip zone margins and increase stress outside the slip zone, driving both interplate and intraplate aftershock occurrence near the periphery of the mainshock slip. The shear stress reduction in large-slip regions during the mainshock is generally sufficient to preclude further significant rupture during the aftershock sequence, consistent with large-slip areas relocking and not rupturing again for a substantial time. PMID:29487902

Building destruction from waves and surge on the bolivar peninsula during hurricane ike

USGS Publications Warehouse

Kennedy, A.; Rogers, S.; Sallenger, A.; Gravois, U.; Zachry, B.; Dosa, M.; Zarama, F.

2011-01-01

The Bolivar Peninsula in Texas was severely impacted by Hurricane Ike with strong winds, large waves, widespread inundation, and severe damage. This paper examines the wave and surge climate on Bolivar during the storm and the consequent survival and destruction of buildings. Emphasis is placed on differences between buildings that survived (with varying degrees of damage) and buildings that were completely destroyed. Building elevations are found to be the primary indicator of survival for areas with large waves. Here, buildings that were sufficiently elevated above waves and surge suffered relatively little structural damage, while houses at lower elevations were impacted by large waves and generally completely destroyed. In many areas, the transition from destruction to survival was over a very small elevation range of around 0.5 m. In areas where waves were smaller, survival was possible at much lower elevations. Higher houses that were not inundated still survived, but well-built houses at lower elevations could also survive as the waves were not large enough to cause structural damage. However, the transition height where waves became damaging could not be determined from this study. ?? 2011 American Society of Civil Engineers.

Evaluating the sufficiency of protected lands for maintaining wildlife population connectivity in the northern Rocky Mountains

Treesearch

Samuel A. Cushman; Erin L. Landguth; Curtis H. Flather

2012-01-01

Aim: The goal of this study was to evaluate the sufficiency of the network of protected lands in the U.S. northern Rocky Mountains in providing protection for habitat connectivity for 105 hypothetical organisms. A large proportion of the landscape...

17 CFR 36.2 - Exempt boards of trade.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Section 36.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXEMPT MARKETS § 36.2... supply that is sufficiently large, and a cash market sufficiently liquid, to render any contract traded... market. (2) The commodities that meet the criteria of paragraph (a)(1) of this section are: (i) The...

17 CFR 36.2 - Exempt boards of trade.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Section 36.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXEMPT MARKETS § 36.2... deliverable supply; (ii) A deliverable supply that is sufficiently large, and a cash market sufficiently... manipulation; or (iii)No cash market. (2) The commodities that meet the criteria of paragraph (a)(1) of this...

17 CFR 36.2 - Exempt boards of trade.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 36.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXEMPT MARKETS § 36.2... deliverable supply; (ii) A deliverable supply that is sufficiently large, and a cash market sufficiently... manipulation; or (iii)No cash market. (2) The commodities that meet the criteria of paragraph (a)(1) of this...

17 CFR 36.2 - Exempt boards of trade.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Section 36.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXEMPT MARKETS § 36.2... deliverable supply; (ii) A deliverable supply that is sufficiently large, and a cash market sufficiently... manipulation; or (iii)No cash market. (2) The commodities that meet the criteria of paragraph (a)(1) of this...

17 CFR 36.2 - Exempt boards of trade.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Section 36.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXEMPT MARKETS § 36.2... supply that is sufficiently large, and a cash market sufficiently liquid, to render any contract traded... market. (2) The commodities that meet the criteria of paragraph (a)(1) of this section are: (i) The...

Power-law versus log-law in wall-bounded turbulence: A large-eddy simulation perspective

NASA Astrophysics Data System (ADS)

Cheng, W.; Samtaney, R.

2014-01-01

The debate whether the mean streamwise velocity in wall-bounded turbulent flows obeys a log-law or a power-law scaling originated over two decades ago, and continues to ferment in recent years. As experiments and direct numerical simulation can not provide sufficient clues, in this study we present an insight into this debate from a large-eddy simulation (LES) viewpoint. The LES organically combines state-of-the-art models (the stretched-vortex model and inflow rescaling method) with a virtual-wall model derived under different scaling law assumptions (the log-law or the power-law by George and Castillo ["Zero-pressure-gradient turbulent boundary layer," Appl. Mech. Rev. 50, 689 (1997)]). Comparison of LES results for Reθ ranging from 105 to 1011 for zero-pressure-gradient turbulent boundary layer flows are carried out for the mean streamwise velocity, its gradient and its scaled gradient. Our results provide strong evidence that for both sets of modeling assumption (log law or power law), the turbulence gravitates naturally towards the log-law scaling at extremely large Reynolds numbers.

Amplitude equation and long-range interactions in underwater sand ripples in one dimension

NASA Astrophysics Data System (ADS)

Schnipper, Teis; Mertens, Keith; Ellegaard, Clive; Bohr, Tomas

2008-10-01

We present an amplitude equation for sand ripples under oscillatory flow in a situation where the sand is moving in a narrow channel and the height profile is practically one dimensional. The equation has the form ht=-γ(h- hmacr )+((hx)2-1)hxx-hxxxx+δ((hx)2)xx which, due to the first term, is neither completely local (it has long-range coupling through the average height hmacr ) nor has local sand conservation. We argue that this is reasonable and show that the equation compares well with experimental observations in narrow channels. We focus in particular on the so-called doubling transition, a secondary instability caused by the sudden decrease in the amplitude of the water motion, leading to the appearance of a new ripple in each trough. This transition is well reproduced for sufficiently large δ (asymmetry between trough and crest). We finally present surprising experimental results showing that long-range coupling is indeed seen in the initial details of the doubling transition, where in fact two small ripples are initially formed, followed by global symmetry breaking removing one of them.

Wide dynamic range enrichment method of semiconducting single-walled carbon nanotubes with weak field centrifugation

NASA Astrophysics Data System (ADS)

Reis, Wieland G.; Tomović, Željko; Weitz, R. Thomas; Krupke, Ralph; Mikhael, Jules

2017-03-01

The potential of single-walled carbon nanotubes (SWCNTs) to outperform silicon in electronic application was finally enabled through selective separation of semiconducting nanotubes from the as-synthesized statistical mix with polymeric dispersants. Such separation methods provide typically high semiconducting purity samples with narrow diameter distribution, i.e. almost single chiralities. But for a wide range of applications high purity mixtures of small and large diameters are sufficient or even required. Here we proof that weak field centrifugation is a diameter independent method for enrichment of semiconducting nanotubes. We show that the non-selective and strong adsorption of polyarylether dispersants on nanostructured carbon surfaces enables simple separation of diverse raw materials with different SWCNT diameter. In addition and for the first time, we demonstrate that increased temperature enables higher purity separation. Furthermore we show that the mode of action behind this electronic enrichment is strongly connected to both colloidal stability and protonation. By giving simple access to electronically sorted SWCNTs of any diameter, the wide dynamic range of weak field centrifugation can provide economical relevance to SWCNTs.

Comparison of Interferometric Time-Series Analysis Techniques with Implications for Future Mission Design

NASA Astrophysics Data System (ADS)

Werner, C. L.; Wegmuller, U.; Strozzi, T.; Wiesmann, A.

2006-12-01

Principle contributors to the noise in differential SAR interferograms are temporal phase stability of the surface, geometry relating to baseline and surface slope, and propagation path delay variations due to tropospheric water vapor and the ionosphere. Time series analysis of multiple interferograms generated from a stack of SAR SLC images seeks to determine the deformation history of the surface while reducing errors. Only those scatterers within a resolution element that are stable and coherent for each interferometric pair contribute to the desired deformation signal. Interferograms with baselines exceeding 1/3 the critical baseline have substantial geometrical decorrelation for distributed targets. Short baseline pairs with multiple reference scenes can be combined using least-squares estimation to obtain a global deformation solution. Alternately point-like persistent scatterers can be identified in scenes that do not exhibit geometrical decorrelation associated with large baselines. In this approach interferograms are formed from a stack of SAR complex images using a single reference scene. Stable distributed scatter pixels are excluded however due to the presence of large baselines. We apply both point- based and short-baseline methodologies and compare results for a stack of fine-beam Radarsat data acquired in 2002-2004 over a rapidly subsiding oil field near Lost Hills, CA. We also investigate the density of point-like scatters with respect to image resolution. The primary difficulty encountered when applying time series methods is phase unwrapping errors due to spatial and temporal gaps. Phase unwrapping requires sufficient spatial and temporal sampling. Increasing the SAR range bandwidth increases the range resolution as well as increasing the critical interferometric baseline that defines the required satellite orbital tube diameter. Sufficient spatial sampling also permits unwrapping because of the reduced phase/pixel gradient. Short time intervals further reduce the differential phase due to deformation when the deformation is continuous. Lower frequency systems (L- vs. C-Band) substantially improve the ability to unwrap the phase correctly by directly reducing both interferometric phase amplitude and temporal decorrelation.

Ion Bernstein instability dependence on the proton-to-electron mass ratio: Linear dispersion theory

NASA Astrophysics Data System (ADS)

Min, Kyungguk; Liu, Kaijun

2016-07-01

Fast magnetosonic waves, which have as their source ion Bernstein instabilities driven by tenuous ring-like proton velocity distributions, are frequently observed in the inner magnetosphere. One major difficulty in the simulation of these waves is that they are excited in a wide frequency range with discrete harmonic nature and require time-consuming computations. To overcome this difficulty, recent simulation studies assumed a reduced proton-to-electron mass ratio, mp/me, and a reduced light-to-Alfvén speed ratio, c/vA, to reduce the number of unstable modes and, therefore, computational costs. Although these studies argued that the physics of wave-particle interactions would essentially remain the same, detailed investigation of the effect of this reduced system on the excited waves has not been done. In this study, we investigate how the complex frequency, ω = ωr+iγ, of the ion Bernstein modes varies with mp/me for a sufficiently large c/vA (such that ωpe2/Ωe2≡(me/mp)(c/vA)2≫1) using linear dispersion theory assuming two different types of energetic proton velocity distributions, namely, ring and shell. The results show that low- and high-frequency harmonic modes respond differently to the change of mp/me. For the low harmonic modes (i.e., ωr˜Ωp), both ωr/Ωp and γ/Ωp are roughly independent of mp/me, where Ωp is the proton cyclotron frequency. For the high harmonic modes (i.e., Ωp≪ωr≲ωlh, where ωlh is the lower hybrid frequency), γ/ωlh (at fixed ωr/ωlh) stays independent of mp/me when the parallel wave number, k∥, is sufficiently large and becomes inversely proportional to (mp/me)1/4 when k∥ goes to zero. On the other hand, the frequency range of the unstable modes normalized to ωlh remains independent of mp/me, regardless of k∥.

On the feasibility to perform integral transmission experiments in the GELINA target hall at IRMM

NASA Astrophysics Data System (ADS)

Leconte, Pierre; Jean, Cyrille De Saint; Geslot, Benoit; Plompen, Arjan; Belloni, Francesca; Nyman, Markus

2017-09-01

Shielding experiments are relevant to validate elastic and inelastic scattering cross sections in the fast energy range. In this paper, we are focusing on the possibility to use the pulsed white neutron time-of-flight facility GELINA to perform this kind of measurement. Several issues need to be addressed: neutron source intensity, room return effect, distance of the materials to be irradiated from the source, and the sensitivity of various reaction rate distributions through the material to different input cross sections. MCNP6 and TRIPOLI4 calculations of the outgoing neutron spectrum are compared, based on electron/positron/gamma/neutron simulations. A first guess of an integral transmission experiment through a 238U slab is considered. It shows that a 10 cm thickness of uranium is sufficient to reach a high sensitivity to the 238U inelastic scattering cross section in the [2-5 MeV] energy range, with small contributions from elastic and fission cross sections. This experiment would contribute to reduce the uncertainty on this nuclear data, which has a significant impact on the power distribution in large commercial reactors. Other materials that would be relevant for the ASTRID 4th generation prototype reactor are also tested, showing that a sufficient sensitivity to nuclear data would be obtained by using a 50 to 100cm thick slab of side 60x60cm. This study concludes on the feasibility and interest of such experiments in the target hall of the GELINA facility.

Interplay of long-range and short-range Coulomb interactions in an Anderson-Mott insulator

NASA Astrophysics Data System (ADS)

Baćani, Mirko; Novak, Mario; Orbanić, Filip; Prša, Krunoslav; Kokanović, Ivan; Babić, Dinko

2017-07-01

In this paper, we tackle the complexity of coexisting disorder and Coulomb electron-electron interactions (CEEIs) in solids by addressing a strongly disordered system with intricate CEEIs and a screening that changes both with charge carrier doping level Q and temperature T . We report on an experimental comparative study of the T dependencies of the electrical conductivity σ and magnetic susceptibility χ of polyaniline pellets doped with dodecylbenzenesulfonic acid over a wide range. This material is special within the class of doped polyaniline by exhibiting in the electronic transport a crossover between a low-T variable range hopping (VRH) and a high-T nearest-neighbor hopping (NNH) well below room temperature. Moreover, there is evidence of a soft Coulomb gap ΔC in the disorder band, which implies the existence of a long-range CEEI. Simultaneously, there is an onsite CEEI manifested as a Hubbard gap U and originating in the electronic structure of doped polyaniline, which consists of localized electron states with dynamically varying occupancy. Therefore, our samples represent an Anderson-Mott insulator in which long-range and short-range CEEIs coexist. The main result of the study is the presence of a crossover between low- and high-T regimes not only in σ (T ) but also in χ (T ) , the crossover temperature T* being essentially the same for both observables over the entire doping range. The relatively large electron localization length along the polymer chains results in U being small, between 12 and 20 meV for the high and low Q , respectively. Therefore, the thermal energy at T* is sufficiently large to lead to an effective closing of the Hubbard gap and the consequent appearance of NNH in the electronic transport within the disorder band. ΔC is considerably larger than U , decreasing from 190 to 30 meV as Q increases, and plays the role of an activation energy in the NNH.

Hand coverage by alcohol-based handrub varies: Volume and hand size matter.

PubMed

Zingg, Walter; Haidegger, Tamas; Pittet, Didier

2016-12-01

Visitors of an infection prevention and control conference performed hand hygiene with 1, 2, or 3 mL ultraviolet light-traced alcohol-based handrub. Coverage of palms, dorsums, and fingertips were measured by digital images. Palms of all hand sizes were sufficiently covered when 2 mL was applied, dorsums of medium and large hands were never sufficiently covered. Palmar fingertips were sufficiently covered when 2  or 3 mL was applied, and dorsal fingertips were never sufficiently covered. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Low-frequency source parameters of twelve large earthquakes. M.S. Thesis

NASA Technical Reports Server (NTRS)

Harabaglia, Paolo

1993-01-01

A global survey of the low-frequency (1-21 mHz) source characteristics of large events are studied. We are particularly interested in events unusually enriched in low-frequency and in events with a short-term precursor. We model the source time function of 12 large earthquakes using teleseismic data at low frequency. For each event we retrieve the source amplitude spectrum in the frequency range between 1 and 21 mHz with the Silver and Jordan method and the phase-shift spectrum in the frequency range between 1 and 11 mHz with the Riedesel and Jordan method. We then model the source time function by fitting the two spectra. Two of these events, the 1980 Irpinia, Italy, and the 1983 Akita-Oki, Japan, are shallow-depth complex events that took place on multiple faults. In both cases the source time function has a length of about 100 seconds. By comparison Westaway and Jackson find 45 seconds for the Irpinia event and Houston and Kanamori about 50 seconds for the Akita-Oki earthquake. The three deep events and four of the seven intermediate-depth events are fast rupturing earthquakes. A single pulse is sufficient to model the source spectra in the frequency range of our interest. Two other intermediate-depth events have slower rupturing processes, characterized by a continuous energy release lasting for about 40 seconds. The last event is the intermediate-depth 1983 Peru-Ecuador earthquake. It was first recognized as a precursive event by Jordan. We model it with a smooth rupturing process starting about 2 minutes before the high frequency origin time superimposed to an impulsive source.

Local alternative energy futures: developing economies/building communities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Totten, M.; Glass, B.; Freedberg, M.

A separate abstract was prepared for each of the three parts of the conference. A sufficient range of information is presented to enable interested parties to explore the viable alternatives for community self-sufficiency. The parts are entitled: Financial Incentives and Funding Sources; Standards, Regulations, Mandates, Ordinances, Covenants; and Community/Economic Development. (MCW)

Viscous Analysis of Pulsating Hydrodynamic Instability and Thermal Coupling Liquid-Propellant Combustion

NASA Technical Reports Server (NTRS)

Margolis, Stephen B.; Sacksteder, Kurt (Technical Monitor)

2000-01-01

A pulsating form of hydrodynamic instability has recently been shown to arise during liquid-propellant deflagration in those parameter regimes where the pressure-dependent burning rate is characterized by a negative pressure sensitivity. This type of instability can coexist with the classical cellular, or Landau form of hydrodynamic instability, with the occurrence of either dependent on whether the pressure sensitivity is sufficiently large or small in magnitude. For the inviscid problem, it has been shown that, when the burning rate is realistically allowed to depend on temperature as well as pressure, sufficiently large values of the temperature sensitivity relative to the pressure sensitivity causes like pulsating form of hydrodynamic instability to become dominant. In that regime, steady, planar burning becomes intrinsically unstable to pulsating disturbances whose wave numbers are sufficiently small. This analysis is extended to the fully viscous case, where it is shown that although viscosity is stabilizing for intermediate and larger wave number perturbations, the intrinsic pulsating instability for small wave numbers remains. Under these conditions, liquid-propellant combustion is predicted to be characterized by large unsteady cells along the liquid/gas interface.

Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum

PubMed Central

Tucker, Kathryn; Stolze, Jessica L.; Kennedy, Aaron H.; Money, Nicholas P.

2007-01-01

Conidial dispersal in Stachybotrys chartarum in response to low-velocity airflow was studied using a microflow apparatus. The maximum rate of spore release occurred during the first 5 min of airflow, followed by a dramatic reduction in dispersal that left more than 99% of the conidia attached to their conidiophores. Micromanipulation of undisturbed colonies showed that micronewton (μN) forces were needed to dislodge spore clusters from their supporting conidiophores. Calculations show that airspeeds that normally prevail in the indoor environment disturb colonies with forces that are 1,000-fold lower, in the nanonewton (nN) range. Low-velocity airflow does not, therefore, cause sufficient disturbance to disperse a large proportion of the conidia of S. chartarum. PMID:17267247

Experimental studies of a zeeman-tuned xenon laser differential absorption apparatus.

PubMed

Linford, G J

1973-06-01

A Zeeman-tuned cw xenon laser differential absorption device is described. The xenon laser was tuned by axial magnetic fields up to 5500 G generated by an unusually large water-cooled dc solenoid. Xenon laser lines at 3.37 micro, 3.51 micro, and 3.99 micro were tuned over ranges of 6 A, 6 A, and 11 A, respectively. To date, this apparatus has been used principally to study the details of formaldehyde absorption lines lying near the 3 .508-micro xenon laser transition. These experiments revealed that the observed absorption spectrum of formaldehyde exhibits a sufficiently unique spectral structure that the present technique may readily be used to measure relative concentrations of formaldehyde in samples of polluted air.

Pure electrical, highly-efficient and sidelobe free coherent Raman spectroscopy using acousto-optics tunable filter (AOTF)

NASA Astrophysics Data System (ADS)

Meng, Zhaokai; Petrov, Georgi I.; Yakovlev, Vladislav V.

2016-02-01

Fast and sensitive Raman spectroscopy measurements are imperative for a large number of applications in biomedical imaging, remote sensing and material characterization. Stimulated Raman spectroscopy offers a substantial improvement in the signal-to-noise ratio but is often limited to a discrete number of wavelengths. In this report, by introducing an electronically-tunable acousto-optical filter as a wavelength selector, a novel approach to a broadband stimulated Raman spectroscopy is demonstrated. The corresponding Raman shift covers the spectral range from 600 cm-1 to 4500 cm-1, sufficient for probing most vibrational Raman transitions. We validated the use of the new instrumentation to both coherent anti-Stokes scattering (CARS) and stimulated Raman scattering (SRS) spectroscopies.

Know how to maximize maintenance spending

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carrino, A.J.; Jones, R.B.; Platt, W.E.

Solomon has developed a methodology to determine a large optimum point where availability meets maintenance spending for Powder River Basin (PRB) coal-fired units. Using a database of sufficient size and composition across various operating ranges, Solomon generated an algorithm that predicts the relationship between maintenance spending and availability. Coupling this generalized algorithm with a unit-specific market-loss curve determines the optimum spending for a facility. The article presents the results of the analysis, how this methodology can be applied to develop optimum operating and financial targets for specific units and markets and a process to achieve those targets. It also describesmore » how this methodology can be used for other types of fossil-fired technologies and future enhancements to the analysis. 5 figs.« less

Design of a 6 TeV muon collider

DOE PAGES

Wang, M-H.; Nosochkov, Y.; Cai, Y.; ...

2016-09-09

Here, a preliminary design of a muon collider ring with the center of mass (CM) energy of 6 TeV is presented. The ring circumference is 6.3 km, and themore » $$\\beta$$ functions at collision point are 1 cm in each plane. The ring linear optics, the non-linear chromaticity compensation in the Interaction Region (IR), and the additional non-linear orthogonal correcting knobs are described. Magnet specifications are based on the maximum pole-tip field of 20T in dipoles and 15T in quadrupoles. Careful compensation of the non-linear chromatic and amplitude dependent effects provide a sufficiently large dynamic aperture for the momentum range of up to $$\\pm$$0.5% without considering magnet errors.« less

Interference testing methods of large astronomical mirrors base on lenses and CGH wavefront correctors

NASA Astrophysics Data System (ADS)

Abdulkadyrov, Magomed A.; Belousov, Sergey P.; Patrikeev, Vladimir E.; Semenov, Alexandr P.

2010-07-01

Since last years and at present days LZOS, JSC has been producing a range of primary mirrors of astronomical telescopes with diameter more than 1m under contracts with foreign companies. Simultaneous testing of an aspherical surface figure by means of a lens corrector and CGH (computer generated hologram) corrector, testing of the corrector using the CGH allow challenging the task of definite testing of the mirrors surfaces figure. The results of successful figuring of the mirrors with diameter up to 4m like VISTA Project (Southern European Observatory), TNT (Thai National telescope, Australia - Thailand), LCO telescopes (Las Cumbres Observatory, USA; Russian national projects and meeting these mirrors specifications' requirements are all considered as the sufficient evidence.

System implications of large radiometric array antennas

NASA Technical Reports Server (NTRS)

Levis, C. A.; Lin, H. C.

1976-01-01

Current radiometric earth and atmospheric sensing systems in the centimeter wavelength range generally employ a directive antenna connected through a single terminal pair to a Dicke receiver. It is shown that this approach does not lend itself to systems with greatly increased spatial resolution. Signal to noise considerations relating to antenna efficiency force the introduction of active elements at the subarray level; thus, if Dicke switching is to be used, it must be distributed throughout the system. Some possible approaches are suggested. The introduction of active elements at the subarray level is found to ease the design constraints on time delay elements, necessary for bandwidth, and on multiple beam generation, required in order to achieve sufficient integration time with high resolution.

Examination of products of conception terminated after prenatal investigation.

PubMed Central

Knowles, S

1986-01-01

A large number of district general hospitals have access to diagnostic ultrasonography and other methods of prenatal diagnosis, resulting in an increased supply of freshly terminated malformed fetuses to general histopathology departments, and there is now more open discussion of malformation and greater concern over fetal wastage. General pathologists are therefore under greater pressure to produce complete and detailed descriptions of a wide range of often complex anomalies. The dismissal of specimens as "multiple congenital anomalies" is becoming increasingly unacceptable to couples who wish to embark on further pregnancies and to their medical attendants. As in other fields an understanding of the methods and terminology in clinical use and a consistent diagnostic approach should help pathologists to extract sufficient information for accurate counselling. Images PMID:3537013

High-Resolution Large Field-of-View FUV Compact Camera

NASA Technical Reports Server (NTRS)

Spann, James F.

2006-01-01

The need for a high resolution camera with a large field of view and capable to image dim emissions in the far-ultraviolet is driven by the widely varying intensities of FUV emissions and spatial/temporal scales of phenomena of interest in the Earth% ionosphere. In this paper, the concept of a camera is presented that is designed to achieve these goals in a lightweight package with sufficient visible light rejection to be useful for dayside and nightside emissions. The camera employs the concept of self-filtering to achieve good spectral resolution tuned to specific wavelengths. The large field of view is sufficient to image the Earth's disk at Geosynchronous altitudes and capable of a spatial resolution of >20 km. The optics and filters are emphasized.

In situ Neutron Diffraction during Casting: Determination of Rigidity Point in Grain Refined Al-Cu Alloys

PubMed Central

Drezet, Jean-Marie; Mireux, Bastien; Szaraz, Zoltan; Pirling, Thilo

2014-01-01

The rigidity temperature of a solidifying alloy is the temperature at which the solid plus liquid phases are sufficiently coalesced to transmit long range tensile strains and stresses. It determines the point at which thermally induced deformations start to generate internal stresses in a casting. As such, it is a key parameter in numerical modelling of solidification processes and in studying casting defects such as solidification cracking. This temperature has been determined in Al-Cu alloys using in situ neutron diffraction during casting in a dog bone shaped mould. In such a setup, the thermal contraction of the solidifying material is constrained and stresses develop at a hot spot that is irradiated by neutrons. Diffraction peaks are recorded every 11 s using a large detector, and their evolution allows for the determination of the rigidity temperatures. We measured rigidity temperatures equal to 557 °C and 548 °C, depending on cooling rate, for a grain refined Al-13 wt% Cu alloy. At high cooling rate, rigidity is reached during the formation of the eutectic phase and the solid phase is not sufficiently coalesced, i.e., strong enough, to avoid hot tear formation. PMID:28788507

Concept for maritime near-surface surveillance using water Raman scattering

DOE PAGES

Shokair, Isaac R.; Johnson, Mark S.; Schmitt, Randal L.; ...

2018-06-08

Here, we discuss a maritime surveillance and detection concept based on Raman scattering of water molecules. Using a range-gated scanning lidar that detects Raman scattered photons from water, the absence or change of signal indicates the presence of a non-water object. With sufficient spatial resolution, a two-dimensional outline of the object can be generated by the scanning lidar. Because Raman scattering is an inelastic process with a relatively large wavelength shift for water, this concept avoids the often problematic elastic scattering for objects at or very close to the water surface or from the bottom surface for shallow waters. Themore » maximum detection depth for this concept is limited by the attenuation of the excitation and return Raman light in water. If excitation in the UV is used, fluorescence can be used for discrimination between organic and non-organic objects. In this paper, we present a lidar model for this concept and discuss results of proof-of-concept measurements. Using published cross section values, the model and measurements are in reasonable agreement and show that a sufficient number of Raman photons can be generated for modest lidar parameters to make this concept useful for near-surface detection.« less

Spectral Gap Estimates in Mean Field Spin Glasses

NASA Astrophysics Data System (ADS)

Ben Arous, Gérard; Jagannath, Aukosh

2018-05-01

We show that mixing for local, reversible dynamics of mean field spin glasses is exponentially slow in the low temperature regime. We introduce a notion of free energy barriers for the overlap, and prove that their existence imply that the spectral gap is exponentially small, and thus that mixing is exponentially slow. We then exhibit sufficient conditions on the equilibrium Gibbs measure which guarantee the existence of these barriers, using the notion of replicon eigenvalue and 2D Guerra Talagrand bounds. We show how these sufficient conditions cover large classes of Ising spin models for reversible nearest-neighbor dynamics and spherical models for Langevin dynamics. Finally, in the case of Ising spins, Panchenko's recent rigorous calculation (Panchenko in Ann Probab 46(2):865-896, 2018) of the free energy for a system of "two real replica" enables us to prove a quenched LDP for the overlap distribution, which gives us a wider criterion for slow mixing directly related to the Franz-Parisi-Virasoro approach (Franz et al. in J Phys I 2(10):1869-1880, 1992; Kurchan et al. J Phys I 3(8):1819-1838, 1993). This condition holds in a wider range of temperatures.

In situ Neutron Diffraction during Casting: Determination of Rigidity Point in Grain Refined Al-Cu Alloys.

PubMed

Drezet, Jean-Marie; Mireux, Bastien; Szaraz, Zoltan; Pirling, Thilo

2014-02-12

The rigidity temperature of a solidifying alloy is the temperature at which the solid plus liquid phases are sufficiently coalesced to transmit long range tensile strains and stresses. It determines the point at which thermally induced deformations start to generate internal stresses in a casting. As such, it is a key parameter in numerical modelling of solidification processes and in studying casting defects such as solidification cracking. This temperature has been determined in Al-Cu alloys using in situ neutron diffraction during casting in a dog bone shaped mould. In such a setup, the thermal contraction of the solidifying material is constrained and stresses develop at a hot spot that is irradiated by neutrons. Diffraction peaks are recorded every 11 s using a large detector, and their evolution allows for the determination of the rigidity temperatures. We measured rigidity temperatures equal to 557 °C and 548 °C, depending on cooling rate, for a grain refined Al-13 wt% Cu alloy. At high cooling rate, rigidity is reached during the formation of the eutectic phase and the solid phase is not sufficiently coalesced, i.e. , strong enough, to avoid hot tear formation.

Concept for maritime near-surface surveillance using water Raman scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shokair, Isaac R.; Johnson, Mark S.; Schmitt, Randal L.

Here, we discuss a maritime surveillance and detection concept based on Raman scattering of water molecules. Using a range-gated scanning lidar that detects Raman scattered photons from water, the absence or change of signal indicates the presence of a non-water object. With sufficient spatial resolution, a two-dimensional outline of the object can be generated by the scanning lidar. Because Raman scattering is an inelastic process with a relatively large wavelength shift for water, this concept avoids the often problematic elastic scattering for objects at or very close to the water surface or from the bottom surface for shallow waters. Themore » maximum detection depth for this concept is limited by the attenuation of the excitation and return Raman light in water. If excitation in the UV is used, fluorescence can be used for discrimination between organic and non-organic objects. In this paper, we present a lidar model for this concept and discuss results of proof-of-concept measurements. Using published cross section values, the model and measurements are in reasonable agreement and show that a sufficient number of Raman photons can be generated for modest lidar parameters to make this concept useful for near-surface detection.« less

Electrohydrodynamic properties of succinoglycan as probed by fluorescence correlation spectroscopy, potentiometric titration and capillary electrophoresis.

PubMed

Duval, Jérôme F L; Slaveykova, Vera I; Hosse, Monika; Buffle, Jacques; Wilkinson, Kevin J

2006-10-01

The electrostatic, hydrodynamic and conformational properties of aqueous solutions of succinoglycan have been analyzed by fluorescence correlation spectroscopy (FCS), proton titration, and capillary electrophoresis (CE) over a large range of pH values and electrolyte (NaCl) concentrations. Using the theoretical formalism developed previously for the electrokinetic properties of soft, permeable particles, a quantitative analysis for the electro-hydrodynamics of succinoglycan is performed by taking into account, in a self-consistent manner, the measured values of the diffusion coefficients, electric charge densities, and electrophoretic mobilities. For that purpose, two limiting conformations for the polysaccharide in solution are tested, i.e. succinoglycan behaves as (i) a spherical, random coil polymer or (ii) a rodlike particle with charged lateral chains. The results show that satisfactory modeling of the titration data for ionic strengths larger than 50 mM can be accomplished using both geometries over the entire range of pH values. Electrophoretic mobilities measured for sufficiently large pH values (pH > 5-6) are in line with predictions based on either model. The best manner to discriminate between these two conceptual models is briefly discussed. For low pH values (pH < 5), both models indicate aggregation, resulting in an increase of the hydrodynamic permeability and a decrease of the diffusion coefficient.

Theory and phenomenology of Planckian interacting massive particles as dark matter

NASA Astrophysics Data System (ADS)

Garny, Mathias; Palessandro, Andrea; Sandora, McCullen; Sloth, Martin S.

2018-02-01

Planckian Interacting Dark Matter (PIDM) is a minimal scenario of dark matter assuming only gravitational interactions with the standard model and with only one free parameter, the PIDM mass. PIDM can be successfully produced by gravitational scattering in the thermal plasma of the Standard Model sector after inflation in the PIDM mass range from TeV up to the GUT scale, if the reheating temperature is sufficiently high. The minimal assumption of a GUT scale PIDM mass can be tested in the future by measurements of the primordial tensor-to-scalar ratio. While large primordial tensor modes would be in tension with the QCD axion as dark matter in a large mass range, it would favour the PIDM as a minimal alternative to WIMPs. Here we generalise the previously studied scalar PIDM scenario to the case of fermion, vector and tensor PIDM scenarios, and show that the phenomenology is nearly identical, independent of the spin of the PIDM. We also consider the specific realisation of the PIDM as the Kaluza-Klein excitation of the graviton in orbifold compactifications of string theory, as well as in models of monodromy inflation and in Higgs inflation. Finally we discuss the possibility of indirect detection of PIDM through non-perturbative decay.

Smart City Pilot Projects Using LoRa and IEEE802.15.4 Technologies.

PubMed

Pasolini, Gianni; Buratti, Chiara; Feltrin, Luca; Zabini, Flavio; De Castro, Cristina; Verdone, Roberto; Andrisano, Oreste

2018-04-06

Information and Communication Technologies (ICTs), through wireless communications and the Internet of Things (IoT) paradigm, are the enabling keys for transforming traditional cities into smart cities, since they provide the core infrastructure behind public utilities and services. However, to be effective, IoT-based services could require different technologies and network topologies, even when addressing the same urban scenario. In this paper, we highlight this aspect and present two smart city testbeds developed in Italy. The first one concerns a smart infrastructure for public lighting and relies on a heterogeneous network using the IEEE 802.15.4 short-range communication technology, whereas the second one addresses smart-building applications and is based on the LoRa low-rate, long-range communication technology. The smart lighting scenario is discussed providing the technical details and the economic benefits of a large-scale (around 3000 light poles) flexible and modular implementation of a public lighting infrastructure, while the smart-building testbed is investigated, through measurement campaigns and simulations, assessing the coverage and the performance of the LoRa technology in a real urban scenario. Results show that a proper parameter setting is needed to cover large urban areas while maintaining the airtime sufficiently low to keep packet losses at satisfactory levels.

Smart City Pilot Projects Using LoRa and IEEE802.15.4 Technologies

PubMed Central

Buratti, Chiara; Zabini, Flavio; De Castro, Cristina; Verdone, Roberto; Andrisano, Oreste

2018-01-01

Information and Communication Technologies (ICTs), through wireless communications and the Internet of Things (IoT) paradigm, are the enabling keys for transforming traditional cities into smart cities, since they provide the core infrastructure behind public utilities and services. However, to be effective, IoT-based services could require different technologies and network topologies, even when addressing the same urban scenario. In this paper, we highlight this aspect and present two smart city testbeds developed in Italy. The first one concerns a smart infrastructure for public lighting and relies on a heterogeneous network using the IEEE 802.15.4 short-range communication technology, whereas the second one addresses smart-building applications and is based on the LoRa low-rate, long-range communication technology. The smart lighting scenario is discussed providing the technical details and the economic benefits of a large-scale (around 3000 light poles) flexible and modular implementation of a public lighting infrastructure, while the smart-building testbed is investigated, through measurement campaigns and simulations, assessing the coverage and the performance of the LoRa technology in a real urban scenario. Results show that a proper parameter setting is needed to cover large urban areas while maintaining the airtime sufficiently low to keep packet losses at satisfactory levels. PMID:29642391

Drivers of reforestation in human-dominated forests

PubMed Central

Nagendra, Harini

2007-01-01

Tropical forest habitat continues to decline globally, with serious negative consequences for environmental sustainability. The small mountain country of Nepal provides an excellent context in which to examine trajectories of forest-cover change. Despite having experienced large-scale forest clearing in the past, significant reforestation has taken place in recent years. The range of biophysical and ecological environments and diversity of tenure arrangements provide us with a context with sufficient variation to be able to derive insight into the impact of a range of hypothesized drivers of forest change. This article draws on a dataset of 55 forests from the middle hills and Terai plains of Nepal to examine the factors associated with forest clearing or regeneration. Results affirm the central importance of tenure regimes and local monitoring for forest regrowth. In addition, user group size per unit of forest area is an important, independent explanator of forest change. These variables also can be associated with specific practices that further influence forest change such as the management of social conflict, adoption of new technologies to reduce pressure on the forest, and involvement of users in forest maintenance activities. Such large-N, comparative studies are essential if we are to derive more complex, nuanced, yet actionable frameworks that help us to plan better policies for the management of natural resources. PMID:17881576

Materials modification using ions with energies below 1 MeV/u

NASA Astrophysics Data System (ADS)

Karlušić, M.; Jakšić, M.; Buljan, M.; Sancho-Parramon, J.; Bogdanović-Radović, I.; Radić, N.; Bernstorff, S.

2013-12-01

Materials modifications using swift heavy ion beams provided by large scale accelerators have been used for many years in a wide variety of ways, e.g. to produce ion tracks or to modify the shape of nanoparticles. In all those applications the most relevant parameter for the materials modification is the electronic stopping power and not the ion kinetic energy. For many materials, ions with energies below 1 MeV/u delivered from medium and small size accelerators have already sufficiently high electronic stopping power to modify materials in different ways. Also, in this energy range the nuclear stopping power can be large enough to provide additional opportunities for materials modifications. In the present paper, we review recent experimental activities of the Zagreb group where ion beams with energies below 1 MeV/u, obtained from a 6 MV EN Tandem Van de Graaff accelerator have been used. Additionally, we present several novel examples of materials modifications and their analysis with such ion beams.

Rapid assessment of target species: Byssate bivalves in a large tropical port.

PubMed

Minchin, Dan; Olenin, Sergej; Liu, Ta-Kang; Cheng, Muhan; Huang, Sheng-Chih

2016-11-15

Rapid assessment sampling for target species is a fast cost-effective method aimed at determining the presence, abundance and distribution of alien and native harmful aquatic organisms and pathogens that may have been introduced by shipping. In this study, the method was applied within a large tropical port expected to have a high species diversity. The port of Kaohsiung was sampled for bivalve molluscan species that attach using a byssus. Such species, due to their biological traits, are spread by ships to ports worldwide. We estimated the abundance and distribution range of one dreissenid (Mytilopsis sallei) and four mytilids (Brachidontes variabilis, Arcuatula senhousa, Mytilus galloprovincialis, Perna viridis) known to be successful invaders and identified as potential pests, or high-risk harmful native or non-native species. We conclude that a rapid assessment of their abundance and distribution within a port, and its vicinity, is efficient and can provide sufficient information for decision making by port managers where IMO port exemptions may be sought. Copyright © 2016. Published by Elsevier Ltd.

The molecular composition of dense interstellar clouds

NASA Technical Reports Server (NTRS)

Allen, M.; Robinson, G. W.

1977-01-01

Presented in this paper is an ab initio chemical model for dense interstellar clouds that incorporates 598 grain surface reactions, with small grains providing the reaction area. Gas-phase molecules are depleted through collisions with grains. The abundances of 372 chemical species are calculated as a function of time and are found to be of sufficient magnitude to explain most observations. Peak abundances are achieved on time scales of the order of 100,000 to 1 million years, depending on cloud density and kinetic temperature. The reaction rates for ion-molecule chemistry are approximately the same, indicating that surface and gas-phase chemistry may be coupled in certain regions. The composition of grain mantles is shown to be a function of grain radius. In certain grain-size ranges, large molecules containing two or more heavy atoms are more predominant than lighter 'ices' - H2O, NH3, and CH4. It is possible that absorption due to these large molecules in the mantle may contribute to the observed 3-micron band in astronomical spectra.

Dissociative recombination of the ground state of N2(+)

NASA Technical Reports Server (NTRS)

Guberman, Steven L.

1991-01-01

Large-scale calculations of the dissociative recombination cross sections and rates for the v = 0 level of the N2(+) ground state are reported, and the important role played by vibrationally excited Rydberg states lying both below and above the v = 0 level of the ion is demonstrated. The large-scale electronic wave function calculations were done using triple zeta plus polarization nuclear-centered-valence Gaussian basis sets. The electronic widths were obtained using smaller wave functions, and the cross sections were calculated on the basis of the multichannel quantum defect theory. The DR rate is calculated at 1.6 x 10 to the -7th x (Te/300) to the -0.37 cu cm/sec for Te in the range of 100 to 1000 K, and is found to be in excellent agreement with prior microwave afterglow experiments but in disagreement with recent merged beam results. It is inferred that the dominant mechanism for DR imparts sufficient energy to the product atoms to allow for escape from the Martian atmosphere.

Investigation of laser-induced iodine fluorescence for the measurement of density in compressible flows

NASA Technical Reports Server (NTRS)

Mcdaniel, J. C., Jr.

1982-01-01

Laser induced fluorescence is an attractive nonintrusive approach for measuring molecular number density in compressible flows although this technique does not produce a signal that is directly related to the number density. Saturation and frequency detuned excitation are explored as means for minimizing the quenching effect using iodine as the molecular system because of its convenient absorption spectrum. Saturation experiments indicate that with available continuous wave laser sources of Gaussian transverse intensity distribution only partial saturation could be achieved in iodine at the pressures of interest in gas dynamics. Using a fluorescence lineshape theory, it is shown that for sufficiently large detuning of a narrow bandwidth laser from a molecular transition, the quenching can be cancelled by collisional broadening over a large range of pressures and temperatures. Experimental data obtained in a Mach 4.3 underexpanded jet of nitrogen seeded with iodine for various single mode argon laser detunings from a strong iodine transition at 5145 A are discussed.

Preservation of protein expression systems at elevated temperatures for portable therapeutic production

PubMed Central

Bessling, Seneca; Thielen, Peter; Zhang, Sherry; Wolfe, Joshua

2017-01-01

Many biotechnology capabilities are limited by stringent storage needs of reagents, largely prohibiting use outside of specialized laboratories. Focusing on a large class of protein-based biotechnology applications, we address this issue by developing a method for preserving cell-free protein expression systems for months above room temperature. Our approach realizes unprecedented long-term stability at elevated temperatures by leveraging the sugar alcohol trehalose, a simple, low-cost, open-air drying step, and strategic separation of reaction components during drying. The resulting preservation capacity enables efficient production of a wide range of on-demand proteins under adverse conditions, for instance during emergency outbreaks or in remote locations. To demonstrate application potential, we use cell-free reagents subjected to months of exposure at 37°C and atmospheric conditions to produce sufficient concentrations of a pyocin protein to kill Pseudomonas aeruginosa, a troublesome pathogen for traumatic and burn wound injuries. Our work makes possible new biotechnology applications that demand ruggedness and scalability. PMID:28446704

Three-mirror anastigmat for cosmic microwave background observations.

PubMed

Padin, S

2018-03-20

An off-axis three-mirror anastigmat is proposed for future cosmic microwave background observations. The telescope has a 5 m diameter primary, giving 1.5 ' angular resolution at λ=2  mm, which is sufficient for measurements of gravitational lensing and for galaxy cluster surveys. The design includes several key features, not previously combined in a large telescope, that are important for sensitive measurements, especially on large angular scales: (1) high throughput (8° diameter diffraction-limited field of view at λ=1  mm, and 12×8° at λ=3  mm, so a single telescope could support all the detectors for an optimistic, future experiment); (2) low scattering (all the mirrors are small enough to be monolithic, so there are no segment gaps); (3) full boresight rotation, over the full elevation range, for measuring polarization errors; and (4) a comoving shield or baffle around the entire telescope to control pickup.

The character of scaling earthquake source spectra for Kamchatka in the 3.5-6.5 magnitude range

NASA Astrophysics Data System (ADS)

Gusev, A. A.; Guseva, E. M.

2017-02-01

The properties of the source spectra of local shallow-focus earthquakes on Kamchatka in the range of magnitudes M w = 3.5-6.5 are studied using 460 records of S-waves obtained at the PET station. The family of average source spectra is constructed; the spectra are used to study the relationship between M w and the key quasi-dimensionless source parameters: stress drop Δσ and apparent stress σa. It is found that the parameter Δσ is almost stable, while σa grows steadily as the magnitude M w increases, indicating that the similarity is violated. It is known that at sufficiently large M w the similarity hypothesis is approximately valid: both parameters Δσ and σa do not show any noticeable magnitude dependence. It has been established that M w ≈ 5.7 is the threshold value of the magnitude when the change in regimes described occurs for the conditions on Kamchatka.

Ground water in the vicinity of Capulin, New Mexico

USGS Publications Warehouse

Hart, D.L.; Smith, Christian

1979-01-01

The alluvial deposits within a closed basin near Capulin, New Mexico, are estimated to have 189,000 acre-feet of water in storage. These deposits have an estimated average transmissivity of 400 feet squared per day and represent the major source of ground water. Well yields range from a few gallons per minute to as much as 900 gallons per minute, with average potential yields ranging from about 100 to 200 gallons per minute in areas of greatest saturated thickness. Additional large quantities of water are available for short-term supplies from the saturated basaltic cinders west and northwest of the town of Capulin. Wells completed in the cinders reportedly have produced as much as 2,000 gallons per minute. The chemical quality of water in the alluvium and cinder aquifers appears to be chemically satisfactory for municipal use. The ground water in storage is sufficient to supplement Raton, New Mexico 's water needs to the year 2030 at the water demand rate projected by the Bureau of Reclamation. (Woodard-USGS)

Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation

PubMed Central

Kasprowicz, Eric M; Davidson, Lance A; Keller, Raymond

2018-01-01

Indirect evidence suggests that blastopore closure during gastrulation of anamniotes, including amphibians such as Xenopus laevis, depends on circumblastoporal convergence forces generated by the marginal zone (MZ), but direct evidence is lacking. We show that explanted MZs generate tensile convergence forces up to 1.5 μN during gastrulation and over 4 μN thereafter. These forces are generated by convergent thickening (CT) until the midgastrula and increasingly by convergent extension (CE) thereafter. Explants from ventralized embryos, which lack tissues expressing CE but close their blastopores, produce up to 2 μN of tensile force, showing that CT alone generates forces sufficient to close the blastopore. Uniaxial tensile stress relaxation assays show stiffening of mesodermal and ectodermal tissues around the onset of neurulation, potentially enhancing long-range transmission of convergence forces. These results illuminate the mechanobiology of early vertebrate morphogenic mechanisms, aid interpretation of phenotypes, and give insight into the evolution of blastopore closure mechanisms. PMID:29533180

A systematic review and meta-analysis of cognitive bias to food stimuli in people with disordered eating behaviour.

PubMed

Brooks, Samantha; Prince, Alexis; Stahl, Daniel; Campbell, Iain C; Treasure, Janet

2011-02-01

Maladaptive cognitions about food, weight and shape bias attention, memory and judgment and may be linked to disordered eating behaviour. This paper reviews information processing of food stimuli (words, pictures) in people with eating disorders (ED). PubMed, Ovid, ScienceDirect, PsychInfo, Web of Science, Cochrane Library and Google Scholar were searched to December 2009. 63 studies measured attention, memory and judgment bias towards food stimuli in women with ED. Stroop tasks had sufficient sample size for a meta-analyses and effects ranged from small to medium. Other studies of attention bias had variable effects (e.g. the Dot-Probe task, distracter tasks and Startle Eyeblink Modulation). A meta-analysis of memory bias studies in ED and RE yielded insignificant effect. Effect sizes for judgment bias ranged from negligible to large. People with ED have greater attentional bias to food stimuli than healthy controls (HC). Evidence for a memory and judgment bias in ED is limited. Copyright © 2010 Elsevier Ltd. All rights reserved.

A Sinusoidal Applied Electric Potential can Induce a Long-Range, Steady Electrophoretic Force

NASA Astrophysics Data System (ADS)

Amrei, Seyyed Hashemi; Ristenpart, William D.; Miller, Greg R.

2017-11-01

We use the standard electrokinetic model to numerically investigate the electric field in aqueous solutions between parallel electrodes under AC polarization. In contrast to prior work, we invoke no simplifying assumptions regarding the applied voltage, frequency, or mismatch in ionic mobilities. We find that the nonlinear electromigration terms significantly contribute to the overall shape of the electric potential vs. time, which at sufficiently high applied potentials develops multi-modal peaks. More surprisingly, we find that electrolytes with non-equal mobilities yield an electric field with non-zero time average at large distances from the electrodes. Our calculations indicate this long-range electric field suffices to levitate colloidal particles many microns away from the electrode against the gravitational field, in accord with experimental observations of such behavior (Woehl et al., PRX, 2015). Moreover, the results indicate that particles will aggregate laterally near electrodes in some electrolytes but separate in others, helping explain a longstanding but not well understood phenomenon.

Grating-assisted demodulation of interferometric optical sensors.

PubMed

Yu, Bing; Wang, Anbo

2003-12-01

Accurate and dynamic control of the operating point of an interferometric optical sensor to produce the highest sensitivity is crucial in the demodulation of interferometric optical sensors to compensate for manufacturing errors and environmental perturbations. A grating-assisted operating-point tuning system has been designed that uses a diffraction grating and feedback control, functions as a tunable-bandpass optical filter, and can be used as an effective demodulation subsystem in sensor systems based on optical interferometers that use broadband light sources. This demodulation method has no signal-detection bandwidth limit, a high tuning speed, a large tunable range, increased interference fringe contrast, and the potential for absolute optical-path-difference measurement. The achieved 40-nm tuning range, which is limited by the available source spectrum width, 400-nm/s tuning speed, and a step resolution of 0.4 nm, is sufficient for most practical measurements. A significant improvement in signal-to-noise ratio in a fiber Fabry-Perot acoustic-wave sensor system proved that the expected fringe contrast and sensitivity increase.

Satellite orbit and data sampling requirements

NASA Technical Reports Server (NTRS)

Rossow, William

1993-01-01

Climate forcings and feedbacks vary over a wide range of time and space scales. The operation of non-linear feedbacks can couple variations at widely separated time and space scales and cause climatological phenomena to be intermittent. Consequently, monitoring of global, decadal changes in climate requires global observations that cover the whole range of space-time scales and are continuous over several decades. The sampling of smaller space-time scales must have sufficient statistical accuracy to measure the small changes in the forcings and feedbacks anticipated in the next few decades, while continuity of measurements is crucial for unambiguous interpretation of climate change. Shorter records of monthly and regional (500-1000 km) measurements with similar accuracies can also provide valuable information about climate processes, when 'natural experiments' such as large volcanic eruptions or El Ninos occur. In this section existing satellite datasets and climate model simulations are used to test the satellite orbits and sampling required to achieve accurate measurements of changes in forcings and feedbacks at monthly frequency and 1000 km (regional) scale.

Preclinical immunogenicity and safety of a Group A streptococcal M protein-based vaccine candidate.

PubMed

Batzloff, Michael R; Fane, Anne; Gorton, Davina; Pandey, Manisha; Rivera-Hernandez, Tania; Calcutt, Ainslie; Yeung, Grace; Hartas, Jon; Johnson, Linda; Rush, Catherine M; McCarthy, James; Ketheesan, Natkunam; Good, Michael F

2016-12-01

Streptococcus pyogenes (group A streptococcus, GAS) causes a wide range of clinical manifestations ranging from mild self-limiting pyoderma to invasive diseases such as sepsis. Also of concern are the post-infectious immune-mediated diseases including rheumatic heart disease. The development of a vaccine against GAS would have a large health impact on populations at risk of these diseases. However, there is a lack of suitable models for the safety evaluation of vaccines with respect to post-infectious complications. We have utilized the Lewis Rat model for cardiac valvulitis to evaluate the safety of the J8-DT vaccine formulation in parallel with a rabbit toxicology study. These studies demonstrated that the vaccine did not induce abnormal pathology. We also show that in mice the vaccine is highly immunogenic but that 3 doses are required to induce protection from a GAS skin challenge even though 2 doses are sufficient to induce a high antibody titer.

Preclinical immunogenicity and safety of a Group A streptococcal M protein-based vaccine candidate

PubMed Central

Batzloff, Michael R.; Fane, Anne; Gorton, Davina; Pandey, Manisha; Rivera-Hernandez, Tania; Calcutt, Ainslie; Yeung, Grace; Hartas, Jon; Johnson, Linda; Rush, Catherine M.; McCarthy, James; Ketheesan, Natkunam; Good, Michael F.

2016-01-01

ABSTRACT Streptococcus pyogenes (group A streptococcus, GAS) causes a wide range of clinical manifestations ranging from mild self-limiting pyoderma to invasive diseases such as sepsis. Also of concern are the post-infectious immune-mediated diseases including rheumatic heart disease. The development of a vaccine against GAS would have a large health impact on populations at risk of these diseases. However, there is a lack of suitable models for the safety evaluation of vaccines with respect to post-infectious complications. We have utilized the Lewis Rat model for cardiac valvulitis to evaluate the safety of the J8-DT vaccine formulation in parallel with a rabbit toxicology study. These studies demonstrated that the vaccine did not induce abnormal pathology. We also show that in mice the vaccine is highly immunogenic but that 3 doses are required to induce protection from a GAS skin challenge even though 2 doses are sufficient to induce a high antibody titer. PMID:27541593

Key issues in the prevention of obesity.

PubMed

Gill, T P

1997-01-01

Obesity is a serious, chronic medical condition which is associated with a wide range of debilitating and life-threatening conditions. It imposes huge financial burdens on health care systems and the community at large. Obesity develops over time and once it has done so, is difficult to treat. Therefore, the prevention of weight gain offers the only truly effective means of controlling obesity. Very little research has directly addressed the issue of obesity prevention and previous efforts to prevent obesity amongst individuals, groups or whole communities have had very limited success. However, we have learned sufficient from past preventive activities to realise that the management of obesity will require a comprehensive range of strategies with actions that target those with existing weight problems, those at high risk of developing obesity as well as the community as a whole. The prevention and management of obesity in children should be considered a priority as there is a high risk of persistence into adulthood.

Driving Chemical Reactions in Plasmonic Nanogaps with Electrohydrodynamic Flow.

PubMed

Thrift, William J; Nguyen, Cuong Q; Darvishzadeh-Varcheie, Mahsa; Zare, Siavash; Sharac, Nicholas; Sanderson, Robert N; Dupper, Torin J; Hochbaum, Allon I; Capolino, Filippo; Abdolhosseini Qomi, Mohammad Javad; Ragan, Regina

2017-11-28

Nanoparticles from colloidal solution-with controlled composition, size, and shape-serve as excellent building blocks for plasmonic devices and metasurfaces. However, understanding hierarchical driving forces affecting the geometry of oligomers and interparticle gap spacings is still needed to fabricate high-density architectures over large areas. Here, electrohydrodynamic (EHD) flow is used as a long-range driving force to enable carbodiimide cross-linking between nanospheres and produces oligomers exhibiting sub-nanometer gap spacing over mm 2 areas. Anhydride linkers between nanospheres are observed via surface-enhanced Raman scattering (SERS) spectroscopy. The anhydride linkers are cleavable via nucleophilic substitution and enable placement of nucleophilic molecules in electromagnetic hotspots. Atomistic simulations elucidate that the transient attractive force provided by EHD flow is needed to provide a sufficient residence time for anhydride cross-linking to overcome slow reaction kinetics. This synergistic analysis shows assembly involves an interplay between long-range driving forces increasing nanoparticle-nanoparticle interactions and probability that ligands are in proximity to overcome activation energy barriers associated with short-range chemical reactions. Absorption spectroscopy and electromagnetic full-wave simulations show that variations in nanogap spacing have a greater influence on optical response than variations in close-packed oligomer geometry. The EHD flow-anhydride cross-linking assembly method enables close-packed oligomers with uniform gap spacings that produce uniform SERS enhancement factors. These results demonstrate the efficacy of colloidal driving forces to selectively enable chemical reactions leading to future assembly platforms for large-area nanodevices.

Rewilding the tropics, and other conservation translocations strategies in the tropical Asia-Pacific region

PubMed Central

Louys, Julien; Corlett, Richard T; Price, Gilbert J; Hawkins, Stuart; Piper, Philip J

2014-01-01

Alarm over the prospects for survival of species in a rapidly changing world has encouraged discussion of translocation conservation strategies that move beyond the focus of ‘at-risk’ species. These approaches consider larger spatial and temporal scales than customary, with the aim of recreating functioning ecosystems through a combination of large-scale ecological restoration and species introductions. The term ‘rewilding’ has come to apply to this large-scale ecosystem restoration program. While reintroductions of species within their historical ranges have become standard conservation tools, introductions within known paleontological ranges—but outside historical ranges—are more controversial, as is the use of taxon substitutions for extinct species. Here, we consider possible conservation translocations for nine large-bodied taxa in tropical Asia-Pacific. We consider the entire spectrum of conservation translocation strategies as defined by the IUCN in addition to rewilding. The taxa considered are spread across diverse taxonomic and ecological spectra and all are listed as ‘endangered’ or ‘critically endangered’ by the IUCN in our region of study. They all have a written and fossil record that is sufficient to assess past changes in range, as well as ecological and environmental preferences, and the reasons for their decline, and they have all suffered massive range restrictions since the late Pleistocene. General principles, problems, and benefits of translocation strategies are reviewed as case studies. These allowed us to develop a conservation translocation matrix, with taxa scored for risk, benefit, and feasibility. Comparisons between taxa across this matrix indicated that orangutans, tapirs, Tasmanian devils, and perhaps tortoises are the most viable taxa for translocations. However, overall the case studies revealed a need for more data and research for all taxa, and their ecological and environmental needs. Rewilding the Asian-Pacific tropics remains a controversial conservation strategy, and would be difficult in what is largely a highly fragmented area geographically. PMID:25540698

Evaluation of the Ticket to Work Program: Assessment of Post-Rollout Implementation and Early Impacts, Volume 1

ERIC Educational Resources Information Center

Thornton, Craig; Livermore, Gina; Fraker, Thomas; Stapleton, David; O'Day, Bonnie; Wittenburg, David; Weathers, Robert; Goodman, Nanette; Silva, Tim; Martin, Emily Sama; Gregory, Jesse; Wright, Debra; Mamun, Arif

2007-01-01

Ticket to Work and Self-Sufficiency program (TTW) was designed to enhance the market for services that help disability beneficiaries become economically self-sufficient by providing beneficiaries with a wide range of choices for obtaining services and to give employment-support service providers new financial incentives to serve beneficiaries…

Determining rates of chemical weathering in soils - Solute transport versus profile evolution

USGS Publications Warehouse

Stonestrom, David A.; White, A.F.; Akstin, K.C.

1998-01-01

SiO2 fluxes associated with contemporary solute transport in three deeply weathered granitoid profiles are compared to bulk SiO2 losses that have occurred during regolith development. Climates at the three profiles range from Mediterranean to humid to tropical. Due to shallow impeding alluvial layers at two of the profiles, and seasonally uniform rainfall at the third, temporal variations in hydraulic and chemical state variables are largely attenuated below depths of 1-2 m. This allows current SiO2 fluxes below the zone of seasonal variations to be estimated from pore-water concentrations and average hydraulic flux densities. Mean-annual SiO2 concentrations were 0.1-1.5 mM. Hydraulic conductivities for the investigated range of soil-moisture saturations ranged from 10-6 m s-1. Estimated hydraulic flux densities for quasi-steady portions of the profiles varied from 6 x 10-9 to 14 x 10-9 m s-1 based on Darcy's law and field measurements of moisture saturations and pressure heads. Corresponding fluid-residence times in the profiles ranged from 10 to 44 years. Total SiO2 losses, based on chemical and volumetric changes in the respective profiles, ranged from 19 to 110 kmoles SiO2 m-2 of land surface as a result of 0.2-0.4 Ma of chemical weathering. Extrapolation of contemporary solute fluxes to comparable time periods reproduced these SiO2 losses to about an order of magnitude. Despite the large range and non-linearity of measured hydraulic conductivities, solute transport rates in weathering regoliths can be estimated from characterization of hydrologic conditions at sufficiently large depths. The agreement suggests that current weathering rates are representative of long-term average weathering rates in the regoliths.SiO2 fluxes associated with contemporary solute transport in three deeply weathered granitoid profiles are compared to bulk SiO2 losses during regolith development. Due to shallow impeding alluvial layers at two of the profiles, and seasonally uniform rainfall at the third, temporal variations in hydraulic and chemical state variables are largely attenuated below depths of 1-2 m. Hydraulic conductivities for the investigated range of soil-moisture saturations of 10-6 m/s-1. Estimated hydraulic flux densities for quasi-steady portions of the profiles varied from 6??10-9 to 14??10-9 m/s based on Darcy's law and field measurements of moisture saturations and pressure heads.

Retear rate in the late postoperative period after arthroscopic rotator cuff repair.

PubMed

Kim, Jae Hwa; Hong, In Tae; Ryu, Keun Jung; Bong, Sun Tae; Lee, Yoon Seok; Kim, Jang Hwan

2014-11-01

Few clinical studies have evaluated the integrity of repaired tendons and identified the timing of retears through the use of serial imaging. Retears after arthroscopic rotator cuff repair are uncommon in the late postoperative period (after 3 months). Case series; Level of evidence, 4. Among 221 arthroscopic rotator cuff repairs that were performed at a single hospital between May 2010 and February 2012, 61 were involved in this study. Rotator cuff tears consisted of 12 small, 31 medium, 8 large, and 6 massive rotator cuff tears. Additionally, 4 isolated subscapularis tears were included. For clinical evaluation, all patients were assessed both preoperatively and postoperatively by use of the University of California-Los Angeles Shoulder Rating Scale, absolute and relative Constant scores, and American Shoulder and Elbow Surgeons score; active range of motion was assessed as well. For radiological evaluation, all 61 patients had a magnetic resonance imaging (MRI) evaluation at 3 months postoperatively. Among them, 23 patients were evaluated for repaired tendon integrity on postoperative MRI at a minimum of 1 year after surgery (mean, 14.1 months; range, 12-19 months), and results were classified according to the Sugaya classification: type I, sufficient thickness with homogeneously low intensity on each image; type II, sufficient thickness, partial high-intensity area; type III, less than half the thickness without discontinuity; type IV, minor discontinuity; and type V, major discontinuity. The remaining 38 patients, who refused to undergo MRI again for financial reasons, were evaluated through ultrasound. Statistically significant clinical improvements were observed after surgery. The MRI conducted at 3 months postoperatively identified 9 patients with Sugaya type I, 28 patients with type II, and 24 patients with type III repairs. No patients showed Sugaya type IV or V repairs at postoperative 3 months. Thirty-seven patients who had shown Sugaya type I or II repairs on 3-month postoperative MRI had no retear on imaging study at a minimum of 1 year. Of 24 patients who had shown type III repairs on 3-month postoperative MRI, 1 patient exhibited retear (Sugaya type IV) on 1-year postoperative MRI and 3 patients showed full-thickness retear on 1-year postoperative ultrasonography. All 4 of these patients had had large to massive tears preoperatively. Retears occurred infrequently in the late postoperative period (after 3 months) in well-healed tendons that had shown intact cuff repair integrity with sufficient mechanical and biological healing within the first 3 postoperative months. © 2014 The Author(s).

High axial resolution imaging system for large volume tissues using combination of inclined selective plane illumination and mechanical sectioning

PubMed Central

Zhang, Qi; Yang, Xiong; Hu, Qinglei; Bai, Ke; Yin, Fangfang; Li, Ning; Gang, Yadong; Wang, Xiaojun; Zeng, Shaoqun

2017-01-01

To resolve fine structures of biological systems like neurons, it is required to realize microscopic imaging with sufficient spatial resolution in three dimensional systems. With regular optical imaging systems, high lateral resolution is accessible while high axial resolution is hard to achieve in a large volume. We introduce an imaging system for high 3D resolution fluorescence imaging of large volume tissues. Selective plane illumination was adopted to provide high axial resolution. A scientific CMOS working in sub-array mode kept the imaging area in the sample surface, which restrained the adverse effect of aberrations caused by inclined illumination. Plastic embedding and precise mechanical sectioning extended the axial range and eliminated distortion during the whole imaging process. The combination of these techniques enabled 3D high resolution imaging of large tissues. Fluorescent bead imaging showed resolutions of 0.59 μm, 0.47μm, and 0.59 μm in the x, y, and z directions, respectively. Data acquired from the volume sample of brain tissue demonstrated the applicability of this imaging system. Imaging of different depths showed uniform performance where details could be recognized in either the near-soma area or terminal area, and fine structures of neurons could be seen in both the xy and xz sections. PMID:29296503

Optical designs of reflection and refraction collection optics for a JT-60SA core Thomson scattering system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tojo, H.; Hatae, T.; Hamano, T.

2013-09-15

Collection optics for core measurements in a JT-60SA Thomson scattering system were designed. The collection optics will be installed in a limited space and have a wide field of view and wide wavelength range. Two types of the optics are therefore suggested: refraction and reflection types. The reflection system, with a large primary mirror, avoids large chromatic aberrations. Because the size limit of the primary mirror and vignetting due to the secondary mirror affect the total collection throughput, conditions that provide the high throughput are found through an optimization. A refraction system with four lenses forming an Ernostar system ismore » also employed. The use of high-refractive-index glass materials enhances the freedom of the lens curvatures, resulting in suppression of the spherical and coma aberration. Moreover, sufficient throughput can be achieved, even with smaller lenses than that of a previous design given in [H. Tojo, T. Hatae, T. Sakuma, T. Hamano, K. Itami, Y. Aida, S. Suitoh, and D. Fujie, Rev. Sci. Instrum. 81, 10D539 (2010)]. The optical resolutions of the reflection and refraction systems are both sufficient for understanding the spatial structures in plasma. In particular, the spot sizes at the image of the optics are evaluated as ∼0.3 mm and ∼0.4 mm, respectively. The throughput for the two systems, including the pupil size and transmissivity, are also compared. The results show that good measurement accuracy (<10%) even at high electron temperatures (<30 keV) can be expected in the refraction system.« less

Optical designs of reflection and refraction collection optics for a JT-60SA core Thomson scattering system.

PubMed

Tojo, H; Hatae, T; Hamano, T; Sakuma, T; Itami, K

2013-09-01

Collection optics for core measurements in a JT-60SA Thomson scattering system were designed. The collection optics will be installed in a limited space and have a wide field of view and wide wavelength range. Two types of the optics are therefore suggested: refraction and reflection types. The reflection system, with a large primary mirror, avoids large chromatic aberrations. Because the size limit of the primary mirror and vignetting due to the secondary mirror affect the total collection throughput, conditions that provide the high throughput are found through an optimization. A refraction system with four lenses forming an Ernostar system is also employed. The use of high-refractive-index glass materials enhances the freedom of the lens curvatures, resulting in suppression of the spherical and coma aberration. Moreover, sufficient throughput can be achieved, even with smaller lenses than that of a previous design given in [H. Tojo, T. Hatae, T. Sakuma, T. Hamano, K. Itami, Y. Aida, S. Suitoh, and D. Fujie, Rev. Sci. Instrum. 81, 10D539 (2010)]. The optical resolutions of the reflection and refraction systems are both sufficient for understanding the spatial structures in plasma. In particular, the spot sizes at the image of the optics are evaluated as ~0.3 mm and ~0.4 mm, respectively. The throughput for the two systems, including the pupil size and transmissivity, are also compared. The results show that good measurement accuracy (<10%) even at high electron temperatures (<30 keV) can be expected in the refraction system.

Global Hopf bifurcation analysis on a BAM neural network with delays

NASA Astrophysics Data System (ADS)

Sun, Chengjun; Han, Maoan; Pang, Xiaoming

2007-01-01

A delayed differential equation that models a bidirectional associative memory (BAM) neural network with four neurons is considered. By using a global Hopf bifurcation theorem for FDE and a Bendixon's criterion for high-dimensional ODE, a group of sufficient conditions for the system to have multiple periodic solutions are obtained when the sum of delays is sufficiently large.

Describing long-range charge-separation processes with subsystem density-functional theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Solovyeva, Alisa; Neugebauer, Johannes, E-mail: j.neugebauer@uni-muenster.de; Pavanello, Michele, E-mail: m.pavanello@rutgers.edu

2014-04-28

Long-range charge-transfer processes in extended systems are difficult to describe with quantum chemical methods. In particular, cost-effective (non-hybrid) approximations within time-dependent density functional theory (DFT) are not applicable unless special precautions are taken. Here, we show that the efficient subsystem DFT can be employed as a constrained DFT variant to describe the energetics of long-range charge-separation processes. A formal analysis of the energy components in subsystem DFT for such excitation energies is presented, which demonstrates that both the distance dependence and the long-range limit are correctly described. In addition, electronic couplings for these processes as needed for rate constants inmore » Marcus theory can be obtained from this method. It is shown that the electronic structure of charge-separated states constructed by a positively charged subsystem interacting with a negatively charged one is difficult to converge — charge leaking from the negative subsystem to the positive one can occur. This problem is related to the delocalization error in DFT and can be overcome with asymptotically correct exchange–correlation (XC) potentials or XC potentials including a sufficiently large amount of exact exchange. We also outline an approximate way to obtain charge-transfer couplings between locally excited and charge-separated states.« less

Similitude assessment method for comparing PMHS response data from impact loading across multiple test devices.

PubMed

Dooley, Christopher J; Tenore, Francesco V; Gayzik, F Scott; Merkle, Andrew C

2018-04-27

Biological tissue testing is inherently susceptible to the wide range of variability specimen to specimen. A primary resource for encapsulating this range of variability is the biofidelity response corridor or BRC. In the field of injury biomechanics, BRCs are often used for development and validation of both physical, such as anthropomorphic test devices, and computational models. For the purpose of generating corridors, post-mortem human surrogates were tested across a range of loading conditions relevant to under-body blast events. To sufficiently cover the wide range of input conditions, a relatively small number of tests were performed across a large spread of conditions. The high volume of required testing called for leveraging the capabilities of multiple impact test facilities, all with slight variations in test devices. A method for assessing similitude of responses between test devices was created as a metric for inclusion of a response in the resulting BRC. The goal of this method was to supply a statistically sound, objective method to assess the similitude of an individual response against a set of responses to ensure that the BRC created from the set was affected primarily by biological variability, not anomalies or differences stemming from test devices. Copyright © 2018 Elsevier Ltd. All rights reserved.

Nuclear structure of bound states of asymmetric dark matter

NASA Astrophysics Data System (ADS)

Gresham, Moira I.; Lou, Hou Keong; Zurek, Kathryn M.

2017-11-01

Models of asymmetric dark matter (ADM) with a sufficiently attractive and long-range force give rise to stable bound objects, analogous to nuclei in the Standard Model, called nuggets. We study the properties of these nuggets and compute their profiles and binding energies. Our approach, applicable to both elementary and composite fermionic ADM, utilizes relativistic mean field theory, and allows a more systematic computation of nugget properties, over a wider range of sizes and force mediator masses, compared to previous literature. We identify three separate regimes of nugget property behavior corresponding to (1) nonrelativistic and (2) relativistic constituents in a Coulomb-like limit, and (3) saturation in an anti-Coulomb limit when the nuggets are large compared to the force range. We provide analytical descriptions for nuggets in each regime. Through numerical calculations, we are able to confirm our analytic descriptions and also obtain smooth transitions for the nugget profiles between all three regimes. We also find that over a wide range of parameter space, the binding energy in the saturation limit is an O (1 ) fraction of the constituent's mass, significantly larger than expectations in the nonrelativistic case. In a companion paper, we apply our results to the synthesis of ADM nuggets in the early Universe.

First results from the IllustrisTNG simulations: matter and galaxy clustering

NASA Astrophysics Data System (ADS)

Springel, Volker; Pakmor, Rüdiger; Pillepich, Annalisa; Weinberger, Rainer; Nelson, Dylan; Hernquist, Lars; Vogelsberger, Mark; Genel, Shy; Torrey, Paul; Marinacci, Federico; Naiman, Jill

2018-03-01

Hydrodynamical simulations of galaxy formation have now reached sufficient volume to make precision predictions for clustering on cosmologically relevant scales. Here, we use our new IllustrisTNG simulations to study the non-linear correlation functions and power spectra of baryons, dark matter, galaxies, and haloes over an exceptionally large range of scales. We find that baryonic effects increase the clustering of dark matter on small scales and damp the total matter power spectrum on scales up to k ˜ 10 h Mpc-1 by 20 per cent. The non-linear two-point correlation function of the stellar mass is close to a power-law over a wide range of scales and approximately invariant in time from very high redshift to the present. The two-point correlation function of the simulated galaxies agrees well with Sloan Digital Sky Survey at its mean redshift z ≃ 0.1, both as a function of stellar mass and when split according to galaxy colour, apart from a mild excess in the clustering of red galaxies in the stellar mass range of109-1010 h-2 M⊙. Given this agreement, the TNG simulations can make valuable theoretical predictions for the clustering bias of different galaxy samples. We find that the clustering length of the galaxy autocorrelation function depends strongly on stellar mass and redshift. Its power-law slope γ is nearly invariant with stellar mass, but declines from γ ˜ 1.8 at redshift z = 0 to γ ˜ 1.6 at redshift z ˜ 1, beyond which the slope steepens again. We detect significant scale dependences in the bias of different observational tracers of large-scale structure, extending well into the range of the baryonic acoustic oscillations and causing nominal (yet fortunately correctable) shifts of the acoustic peaks of around ˜ 5 per cent.

The disruption of multiplanet systems through resonance with a binary orbit.

PubMed

Touma, Jihad R; Sridhar, S

2015-08-27

Most exoplanetary systems in binary stars are of S-type, and consist of one or more planets orbiting a primary star with a wide binary stellar companion. Planetary eccentricities and mutual inclinations can be large, perhaps forced gravitationally by the binary companion. Earlier work on single planet systems appealed to the Kozai-Lidov instability wherein a sufficiently inclined binary orbit excites large-amplitude oscillations in the planet's eccentricity and inclination. The instability, however, can be quenched by many agents that induce fast orbital precession, including mutual gravitational forces in a multiplanet system. Here we report that orbital precession, which inhibits Kozai-Lidov cycling in a multiplanet system, can become fast enough to resonate with the orbital motion of a distant binary companion. Resonant binary forcing results in dramatic outcomes ranging from the excitation of large planetary eccentricities and mutual inclinations to total disruption. Processes such as planetary migration can bring an initially non-resonant system into resonance. As it does not require special physical or initial conditions, binary resonant driving is generic and may have altered the architecture of many multiplanet systems. It can also weaken the multiplanet occurrence rate in wide binaries, and affect planet formation in close binaries.

Coupled three-layer model for turbulent flow over large-scale roughness: On the hydrodynamics of boulder-bed streams

NASA Astrophysics Data System (ADS)

Pan, Wen-hao; Liu, Shi-he; Huang, Li

2018-02-01

This study developed a three-layer velocity model for turbulent flow over large-scale roughness. Through theoretical analysis, this model coupled both surface and subsurface flow. Flume experiments with flat cobble bed were conducted to examine the theoretical model. Results show that both the turbulent flow field and the total flow characteristics are quite different from that in the low gradient flow over microscale roughness. The velocity profile in a shallow stream converges to the logarithmic law away from the bed, while inflecting over the roughness layer to the non-zero subsurface flow. The velocity fluctuations close to a cobble bed are different from that of a sand bed, and it indicates no sufficiently large peak velocity. The total flow energy loss deviates significantly from the 1/7 power law equation when the relative flow depth is shallow. Both the coupled model and experiments indicate non-negligible subsurface flow that accounts for a considerable proportion of the total flow. By including the subsurface flow, the coupled model is able to predict a wider range of velocity profiles and total flow energy loss coefficients when compared with existing equations.

Measurement of resistance switching dynamics in copper sulfide memristor structures

NASA Astrophysics Data System (ADS)

McCreery, Kaitlin; Olson, Matthew; Teitsworth, Stephen

Resistance switching materials are the subject of current research in large part for their potential to enable novel computing devices and architectures such as resistance random access memories and neuromorphic chips. A common feature of memristive structures is the hysteretic switching between high and low resistance states which is induced by the application of a sufficiently large electric field. Here, we describe a relatively simple wet chemistry process to fabricate Cu2 S / Cu memristive structures with Cu2 S film thickness ranging up to 150 micron. In this case, resistance switching is believed to be mediated by electromigration of Cu ions from the Cu substrate into the Cu2 S film. Hysteretic current-voltage curves are measured and reveal switching voltages of about 0.8 Volts with a relatively large variance and independent of film thickness. In order to gain insight into the dynamics and variability of the switching process, we have measured the time-dependent current response to voltage pulses of varying height and duration with a time resolution of 1 ns. The transient response consists of a deterministic RC component as well as stochastically varying abrupt current steps that occur within a few microseconds of the pulse application.

An imaging vector magnetograph for the next solar maximum

NASA Technical Reports Server (NTRS)

Canfield, Richard C.; Mickey, Donald L.

1988-01-01

Measurements of the vector magnetic field in the solar atmosphere with high spatial and temporal resolution over a large field of view are critical to understanding the nature and evolution of currents in active regions. Such measurements, when combined with the thermal and nonthermal X-ray images from the upcoming Solar-A mission, will reveal the large-scale relationship between these currents and sites of heating and particle acceleration in flaring coronal magnetic flux tubes. The conceptual design of an imaging vector magnetograph that combines a modest solar telescope with a rotating quarter-wave plate, an acousto-optical tunable prefilter as a blocker for a servo-controlled Fabry-Perot etalon, CCD cameras, and a rapid digital tape recorder are described. Its high spatial resolution (1/2 arcsec pixel size) over a large field of view (4 x 5 arcmin) will be sufficient to significantly measure, for the first time, the magnetic energy dissipated in major solar flares. Its millisecond tunability and wide spectra range (5000 to 8000 A) enable nearly simultaneous vector magnetic field measurements in the gas-pressure-dominated photosphere and magnetically dominated chromosphere, as well as effective co-alignment with Solar-A's X-ray images.

Zombie Turbulence and More in Stratified Couette Flow

NASA Astrophysics Data System (ADS)

Marcus, Philip; Barranco, Joe; Pei, Suyang; Jiang, Chung-Hsiang

2016-11-01

Zombie turbulence occurs in rotating, shearing vertically-stratified flows such as stratified Couette flows. The turbulence is triggered by a neutrally-stable eigenmode with a critical layer receptive to finite-amplitude perturbations. Once excited, the critical layer becomes a vortex layer pair that rolls up into discrete vortices. Those vortices excite new critical layers, and the process repeats ad infinitum. When the vortex amplitudes become sufficiently large, the flow becomes turbulent. Although possessing a mid-range energy spectrum with E (k) k - 5 / 3 , the turbulence is non-Kolmogorov, highly anisotropic, and with large turbulent, but coherent, structures that retain the length scales of the spacing between the critical layers. The motivation for this study is protoplanetary disks (PPDs) where new stars form. In the PPD the Brunt-Vaisala frequency N increases as a function of distance from the midplane where it is zero. We cannot trigger the initial finite amplitude instability where N is small (close to the midplane). However, computations in PPDs and Couette flows show that zombie turbulence forms where N is large, and then a new type of turbulence, that is neither zombie nor Kolmogorov turbulence, fills in the remainder of the domain even where N = 0 .

Use of fertility drugs and risk of ovarian cancer.

PubMed

Diergaarde, Brenda; Kurta, Michelle L

2014-06-01

The purpose of this review is to highlight recent research and insights into the relationship between fertility drug use and ovarian cancer risk. Results from two large case-control studies provided further evidence that fertility drug use does not significantly contribute to risk of ovarian cancer among the majority of women when adjusting for known confounding factors. However, questions regarding the effect on certain subgroups, including long-term fertility drug users, women who remain nulligravid after fertility treatment, women with BRCA1 or BRCA2 mutations and borderline ovarian tumours, still remain. In addition, it may currently just be too early to determine whether there is an association between fertility drug use and ovarian cancer risk given that many of the exposed women are only now beginning to reach the ovarian cancer age range. Whether use of fertility drugs increases the risk of ovarian cancer is an important question that requires further investigation, in particular given the large number of women utilizing fertility treatments. Fortunately, results from recent studies have been mainly reassuring. Large well designed studies with sufficient follow-up time are needed to further evaluate the effects of fertility treatments within subgroups defined by patient and tumour characteristics.

Internal pilots for a class of linear mixed models with Gaussian and compound symmetric data

PubMed Central

Gurka, Matthew J.; Coffey, Christopher S.; Muller, Keith E.

2015-01-01

SUMMARY An internal pilot design uses interim sample size analysis, without interim data analysis, to adjust the final number of observations. The approach helps to choose a sample size sufficiently large (to achieve the statistical power desired), but not too large (which would waste money and time). We report on recent research in cerebral vascular tortuosity (curvature in three dimensions) which would benefit greatly from internal pilots due to uncertainty in the parameters of the covariance matrix used for study planning. Unfortunately, observations correlated across the four regions of the brain and small sample sizes preclude using existing methods. However, as in a wide range of medical imaging studies, tortuosity data have no missing or mistimed data, a factorial within-subject design, the same between-subject design for all responses, and a Gaussian distribution with compound symmetry. For such restricted models, we extend exact, small sample univariate methods for internal pilots to linear mixed models with any between-subject design (not just two groups). Planning a new tortuosity study illustrates how the new methods help to avoid sample sizes that are too small or too large while still controlling the type I error rate. PMID:17318914

Space Geodesy and the New Madrid Seismic Zone

NASA Astrophysics Data System (ADS)

Smalley, Robert; Ellis, Michael A.

2008-07-01

One of the most contentious issues related to earthquake hazards in the United States centers on the midcontinent and the origin, magnitudes, and likely recurrence intervals of the 1811-1812 New Madrid earthquakes that occurred there. The stakeholder groups in the debate (local and state governments, reinsurance companies, American businesses, and the scientific community) are similar to the stakeholder groups in regions more famous for large earthquakes. However, debate about New Madrid seismic hazard has been fiercer because of the lack of two fundamental components of seismic hazard estimation: an explanatory model for large, midplate earthquakes; and sufficient or sufficiently precise data about the causes, effects, and histories of such earthquakes.

Stability and stabilisation of a class of networked dynamic systems

NASA Astrophysics Data System (ADS)

Liu, H. B.; Wang, D. Q.

2018-04-01

We investigate the stability and stabilisation of a linear time invariant networked heterogeneous system with arbitrarily connected subsystems. A new linear matrix inequality based sufficient and necessary condition for the stability is derived, based on which the stabilisation is provided. The obtained conditions efficiently utilise the block-diagonal characteristic of system parameter matrices and the sparseness of subsystem connection matrix. Moreover, a sufficient condition only dependent on each individual subsystem is also presented for the stabilisation of the networked systems with a large scale. Numerical simulations show that these conditions are computationally valid in the analysis and synthesis of a large-scale networked system.

End-to-End Assessment of a Large Aperture Segmented Ultraviolet Optical Infrared (UVOIR) Telescope Architecture

NASA Technical Reports Server (NTRS)

Feinberg, Lee; Bolcar, Matt; Liu, Alice; Guyon, Olivier; Stark,Chris; Arenberg, Jon

2016-01-01

Key challenges of a future large aperture, segmented Ultraviolet Optical Infrared (UVOIR) Telescope capable of performing a spectroscopic survey of hundreds of Exoplanets will be sufficient stability to achieve 10-10 contrast measurements and sufficient throughput and sensitivity for high yield Exo-Earth spectroscopic detection. Our team has collectively assessed an optimized end to end architecture including a high throughput coronagraph capable of working with a segmented telescope, a cost-effective and heritage based stable segmented telescope, a control architecture that minimizes the amount of new technologies, and an Exo-Earth yield assessment to evaluate potential performance.

Viscous and Thermal Effects on Hydrodynamic Instability in Liquid-Propellant Combustion

NASA Technical Reports Server (NTRS)

Margolis, Stephen B.; Sacksteder, Kurt (Technical Monitor)

2000-01-01

A pulsating form of hydrodynamic instability has recently been shown to arise during the deflagration of liquid propellants in those parameter regimes where the pressure-dependent burning rate is characterized by a negative pressure sensitivity. This type of instability can coexist with the classical cellular, or Landau, form of hydrodynamic instability, with the occurrence of either dependent on whether the pressure sensitivity is sufficiently large or small in magnitude. For the inviscid problem, it has been shown that when the burning rate is realistically allowed to depend on temperature as well as pressure, that sufficiently large values of the temperature sensitivity relative to the pressure sensitivity causes the pulsating form of hydrodynamic instability to become dominant. In that regime, steady, planar burning becomes intrinsically unstable to pulsating disturbances whose wavenumbers are sufficiently small. In the present work, this analysis is extended to the fully viscous case, where it is shown that although viscosity is stabilizing for intermediate and larger wavenumber perturbations, the intrinsic pulsating instability for small wavenumbers remains. Under these conditions, liquid-propellant combustion is predicted to be characterized by large unsteady cells along the liquid/gas interface.

Size effects under homogeneous deformation of single crystals: A discrete dislocation analysis

NASA Astrophysics Data System (ADS)

Guruprasad, P. J.; Benzerga, A. A.

Mechanism-based discrete dislocation plasticity is used to investigate the effect of size on micron scale crystal plasticity under conditions of macroscopically homogeneous deformation. Long-range interactions among dislocations are naturally incorporated through elasticity. Constitutive rules are used which account for key short-range dislocation interactions. These include junction formation and dynamic source and obstacle creation. Two-dimensional calculations are carried out which can handle high dislocation densities and large strains up to 0.1. The focus is laid on the effect of dimensional constraints on plastic flow and hardening processes. Specimen dimensions ranging from hundreds of nanometers to tens of microns are considered. Our findings show a strong size-dependence of flow strength and work-hardening rate at the micron scale. Taylor-like hardening is shown to be insufficient as a rationale for the flow stress scaling with specimen dimensions. The predicted size effect is associated with the emergence, at sufficient resolution, of a signed dislocation density. Heuristic correlations between macroscopic flow stress and macroscopic measures of dislocation density are sought. Most accurate among those is a correlation based on two state variables: the total dislocation density and an effective, scale-dependent measure of signed density.

Increased long-latency reflex activity as a sufficient explanation for childhood hypertonic dystonia: a neuromorphic emulation study

NASA Astrophysics Data System (ADS)

Sohn, Won J.; Niu, Chuanxin M.; Sanger, Terence D.

2015-06-01

Objective. Childhood dystonia is a movement disorder that interferes with daily movements and can have a devastating effect on quality of life for children and their families. Although injury to basal ganglia is associated with dystonia, the neurophysiological mechanisms leading to the clinical manifestations of dystonia are not understood. Previous work suggested that long-latency stretch reflex (LLSR) is hyperactive in children with hypertonia due to secondary dystonia. We hypothesize that abnormal activity in motor cortices may cause an increase in the LLSR leading to hypertonia. Approach. We modeled two possibilities of hyperactive LLSR by either creating a tonic involuntary drive to cortex, or increasing the synaptic gain in cortical neurons. Both models are emulated using programmable very-large-scale-integrated-circuit hardware to test their sufficiency for producing dystonic symptoms. The emulation includes a joint with two Hill-type muscles, realistic muscle spindles, and 2,304 Izhikevich-type spiking neurons. The muscles are regulated by a monosynaptic spinal pathway with 32 ms delay and a long-latency pathway with 64 ms loop-delay representing transcortical/supra-spinal connections. Main results. When the limb is passively stretched, both models produce involuntary resistance with increased antagonist EMG responses similar to human data; also the muscle relaxation is delayed similar to human data. Both models predict reduced range of motion in voluntary movements. Significance. Although our model is a highly simplified and limited representation of reflex pathways, it shows that increased activity of the LLSR is by itself sufficient to cause many of the features of hypertonic dystonia.

Factors associated with variation in home-range size of Appilachian Ruffed Grouse (Bonasa Umbellus)

Treesearch

Darroch M. Whitaker; Dean F. Stauffer; Gary W. Norman; Patrick K. Devers; John Edwards; William M. Giuliano; Craig Harper; William Igo; Harry Spiker; Brian Tefft

2007-01-01

From 1996 to 2001, researchers at 10 Appalachian study sites collected radio tracking data sufficient to delineate 1,054 seasonal home ranges of Ruffed Grouse (Banasa umbellus; hereafter "grouse"). Using information-theoretic model selection and paired comparison of home ranges from individual grouse, we evaluated individual, local, and...

Epitaxial Growth and Cracking Mechanisms of Thermally Sprayed Ceramic Splats

NASA Astrophysics Data System (ADS)

Chen, Lin; Yang, Guan-jun

2018-02-01

In the present study, the epitaxial growth and cracking mechanisms of thermally sprayed ceramic splats were explored. We report, for the first time, the epitaxial growth of various splat/substrate combinations at low substrate temperatures (100 °C) and large lattice mismatch (- 11.26%). Our results suggest that thermal spray deposition was essentially a liquid-phase epitaxy, readily forming chemical bonding. The interface temperature was also estimated. The results convincingly demonstrated that atoms only need to diffuse and rearrange over a sufficiently short range during extremely rapid solidification. Concurrently, severe cracking occurred in the epitaxial splat/substrate systems, which indicated high tensile stress was produced during splat deposition. The origin of the tensile stress was attributed to the strong constraint of the locally heated substrate by its cold surroundings.

Ultrastable, Zerodur-based optical benches for quantum gas experiments.

PubMed

Duncker, Hannes; Hellmig, Ortwin; Wenzlawski, André; Grote, Alexander; Rafipoor, Amir Jones; Rafipoor, Mona; Sengstock, Klaus; Windpassinger, Patrick

2014-07-10

Operating ultracold quantum gas experiments outside of a laboratory environment has so far been a challenging goal, largely due to the lack of sufficiently stable optical systems. In order to increase the thermal stability of free-space laser systems, the application of nonstandard materials such as glass ceramics is required. Here, we report on Zerodur-based optical systems which include single-mode fiber couplers consisting of multiple components jointed by light-curing adhesives. The thermal stability is thoroughly investigated, revealing excellent fiber-coupling efficiencies between 0.85 and 0.92 in the temperature range from 17°C to 36°C. In conjunction with successfully performed vibration tests, these findings qualify our highly compact systems for atom interferometry experiments aboard a sounding rocket as well as various other quantum information and sensing applications.

Calibrating the mental number line.

PubMed

Izard, Véronique; Dehaene, Stanislas

2008-03-01

Human adults are thought to possess two dissociable systems to represent numbers: an approximate quantity system akin to a mental number line, and a verbal system capable of representing numbers exactly. Here, we study the interface between these two systems using an estimation task. Observers were asked to estimate the approximate numerosity of dot arrays. We show that, in the absence of calibration, estimates are largely inaccurate: responses increase monotonically with numerosity, but underestimate the actual numerosity. However, insertion of a few inducer trials, in which participants are explicitly (and sometimes misleadingly) told that a given display contains 30 dots, is sufficient to calibrate their estimates on the whole range of stimuli. Based on these empirical results, we develop a model of the mapping between the numerical symbols and the representations of numerosity on the number line.

Acoustic scattering by benthic shells: Dominant scattering mechanisms and applications

NASA Astrophysics Data System (ADS)

Stanton, Timothy K.; Chu, Dezhang

2004-10-01

When benthic shells occur in sufficiently large numbers, they can dominate acoustic backscattering by the seafloor, especially at angles of incidence away from normal. In order to use sound as a tool to remotely detect and quantify the shells, the scattering properties of the shells need to be understood, both in free-space as well as when placed on the seafloor. Through laboratory experimentation, it has been determined that the edges of certain types of shells (such as bivalves and sand dollars) can dominate the scattering over an important range of grazing angles. The surfaces of these shells and others dominate under other conditions. The dominant scattering effects are discussed in the context of interpreting acoustic backscatter data in terms of meaningful parameters such as numerical density of the shells.

Formation of 2D-PhCs with missing holes based on Si-layers by EBL

NASA Astrophysics Data System (ADS)

Utkin, D. E.; Shklyev, A. A.; Tsarev, A. V.; Latyshev, A. V.

2017-11-01

The fabrication of the periodic structures, that is two-dimensional photonic crystals (2D PhCs) based on Si-materials by electron beam lithography (EBL) technique has been studied. We have investigated basic lithography processes such as designing, exposition, development, etching and others. The developed top-down approach allows close-packed arrays of elements and holes to be formed in nanometre range. This can be used to produce 2D PhCs with emitting micro-cavities (missing holes) with lateral size parameters with an accuracy of about 2% in the Si (100) substrate and in silicon-on-insulator structures. Such accuracy is expected to be sufficient for obtaining the cavities-coupling radiation interference from large areas of 2D PhCs.

Search for TeV gamma ray emission from the Andromeda galaxy

NASA Astrophysics Data System (ADS)

Aharonian, F. A.; Akhperjanian, A. G.; Beilicke, M.; Bernlöhr, K.; Bojahr, H.; Bolz, O.; Börst, H.; Coarasa, T.; Contreras, J. L.; Cortina, J.; Denninghoff, S.; Fonseca, V.; Girma, M.; Götting, N.; Heinzelmann, G.; Hermann, G.; Heusler, A.; Hofmann, W.; Horns, D.; Jung, I.; Kankanyan, R.; Kestel, M.; Kettler, J.; Kohnle, A.; Konopelko, A.; Kornmeyer, H.; Kranich, D.; Krawczynski, H.; Lampeitl, H.; Lopez, M.; Lorenz, E.; Lucarelli, F.; Mang, O.; Meyer, H.; Mirzoyan, R.; Moralejo, A.; Ona, E.; Panter, M.; Plyasheshnikov, A.; Pühlhofer, G.; Rauterberg, G.; Reyes, R.; Rhode, W.; Ripken, J.; Röhring, A.; Rowell, G. P.; Sahakian, V.; Samorski, M.; Schilling, M.; Siems, M.; Sobzynska, D.; Stamm, W.; Tluczykont, M.; Völk, H. J.; Wiedner, C. A.; Wittek, W.

2003-03-01

Using the HEGRA system of imaging atmospheric Cherenkov telescopes, the Andromeda galaxy (M 31) was surveyed for TeV gamma ray emission. Given the large field of view of the HEGRA telescopes, three pointings were sufficient to cover all of M 31, including also M 32 and NGC 205. No indications for point sources of TeV gamma rays were found. Upper limits are given at a level of a few percent of the Crab flux. A specific search for monoenergetic gamma-ray lines from annihilation of supersymmetric dark matter particles accumulating near the center of M 31 resulted in flux limits in the 10-13 cm-2 s-1 range, well above the predicted MSSM flux levels except for models with pronounced dark-matter spikes or strongly enhanced annihilation rates.

A Family of Vortices to Study Axisymmetric Vortex Breakdown and Reconnection

NASA Technical Reports Server (NTRS)

Young, Larry A.

2007-01-01

A new analytic model describing a family of vortices has been developed to study some of the axisymmetric vortex breakdown and reconnection fluid dynamic processes underlying body-vortex interactions that are frequently manifested in rotorcraft and propeller-driven fixed-wing aircraft wakes. The family of vortices incorporates a wide range of prescribed initial vorticity distributions -- including single or dual-core vorticity distributions. The result is analytical solutions for the vorticity and velocities for each member of the family of vortices. This model is of sufficient generality to further illustrate the dependence of vortex reconnection and breakdown on initial vorticity distribution as was suggested by earlier analytical work. This family of vortices, though laminar in nature, is anticipated to provide valuable insight into the vortical evolution of large-scale rotor and propeller wakes.

Second-order optical effects in several pyrazolo-quinoline derivatives

NASA Astrophysics Data System (ADS)

Makowska-Janusik, M.; Gondek, E.; Kityk, I. V.; Wisła, J.; Sanetra, J.; Danel, A.

2004-11-01

Using optical poling of several pyazolo-quinoline (PAQ) derivatives we have found an existence of sufficiently high second order optical susceptibility at wavelength 1.76 μm varying in the range 0.9-2.8 pm/V. The performed quantum chemical simulations of the UV-absorption for isolated, solvated and incorporated into the polymethacrylate (PMMA) polymer films have shown that the PM3 method is the best among the semi-empirical ones to simulate the optical properties. The calculations of the hyperpolarizabilites have shown a good correlation with experimentally measured susceptibilities obtained from the optical poling. We have found that experimental susceptibility depends on linear molecular polarizability and photoinducing changes of the molecular dipole moment. It is clearly seen for the PAQ4-PAQ6 molecules possessing halogen atoms with relatively large polarizabilities.

Baryon asymmetry from primordial black holes

NASA Astrophysics Data System (ADS)

Hamada, Yuta; Iso, Satoshi

2017-03-01

We propose a new scenario of the baryogenesis from primordial black holes (PBH). Assuming the presence of microscopic baryon (or lepton) number violation, and the presence of an effective CP-violating operator such as ∂αF (R…)Jα , where F (R…) is a scalar function of the Riemann tensor and Jα is a baryonic (leptonic) current, the time evolution of an evaporating black hole generates baryonic (leptonic) chemical potential at the horizon; consequently PBH emanates asymmetric Hawking radiation between baryons (leptons) and antibaryons (leptons). Though the operator is higher-dimensional and largely suppressed by a high mass scale M* , we show that a sufficient amount of asymmetry can be generated for a wide range of parameters of the PBH mass MPBH , its abundance ΩPBH , and the scale M*.

Detail of Triton's Surface

NASA Technical Reports Server (NTRS)

1989-01-01

This color photo of Neptune's large satellite Triton was obtained on Aug. 24 1989 at a range of 530,000 kilometers(330,000 miles). The resolution is about 10 kilometers (6.2 miles), sufficient to begin to show topographic detail. The image was made from pictures taken through the green, violet and ultraviolet filters. In this technique, regions that are highly reflective in the ultraviolet appear blue in color. In reality, there is no part of Triton that would appear blue to the eye. The bright southern hemisphere of Triton, which fills most of this frame, is generally pink in tone as is the even brighter equatorial band. The darker regions north of the equator also tend to be pink or reddish in color.

JPL manages the Voyager project for NASA's Office of Space Science.

Vitamin D Deficiency in a Multiethnic Healthy Control Cohort and Altered Immune Response in Vitamin D Deficient European-American Healthy Controls

PubMed Central

Shah, Hemangi B.; Robertson, Julie M.; Fife, Dustin A.; Maecker, Holden T.; Du, Hongwu; Fathman, Charles G.; Chakravarty, Eliza F.; Scofield, R. Hal; Kamen, Diane L.; Guthridge, Joel M.; James, Judith A.

2014-01-01

Objective In recent years, vitamin D has been shown to possess a wide range of immunomodulatory effects. Although there is extensive amount of research on vitamin D, we lack a comprehensive understanding of the prevalence of vitamin D deficiency or the mechanism by which vitamin D regulates the human immune system. This study examined the prevalence and correlates of vitamin D deficiency and the relationship between vitamin D and the immune system in healthy individuals. Methods Healthy individuals (n = 774) comprised of European-Americans (EA, n = 470), African–Americans (AA, n = 125), and Native Americans (NA, n = 179) were screened for 25-hydroxyvitamin D [25(OH)D] levels by ELISA. To identify the most noticeable effects of vitamin D on the immune system, 20 EA individuals with severely deficient (<11.3 ng/mL) and sufficient (>24.8 ng/mL) vitamin D levels were matched and selected for further analysis. Serum cytokine level measurement, immune cell phenotyping, and phosphoflow cytometry were performed. Results Vitamin D sufficiency was observed in 37.5% of the study cohort. By multivariate analysis, AA, NA, and females with a high body mass index (BMI, >30) demonstrate higher rates of vitamin D deficiency (p<0.05). Individuals with vitamin D deficiency had significantly higher levels of serum GM-CSF (p = 0.04), decreased circulating activated CD4+ (p = 0.04) and CD8+ T (p = 0.04) cell frequencies than individuals with sufficient vitamin D levels. Conclusion A large portion of healthy individuals have vitamin D deficiency. These individuals have altered T and B cell responses, indicating that the absence of sufficient vitamin D levels could result in undesirable cellular and molecular alterations ultimately contributing to immune dysregulation. PMID:24727903

DEVELOPMENT OF STANDARDIZED LARGE RIVER BIOASSESSMENT PROTOCOLS (LR-BP) FOR FISH ASSEMBLAGES

EPA Science Inventory

We conducted research comparing several methods currently in use for the bioassessment and monitoring of fish and benthic macroinvertebrate assemblages for large rivers. Fish data demonstrate that electrofishing 1000 m of shoreline is sufficient for bioassessments on boatable ri...

Passive Microwave Remote Sensing of Soil Moisture

NASA Technical Reports Server (NTRS)

Njoku, Eni G.; Entekhabi, Dara

1996-01-01

Microwave remote sensing provides a unique capability for direct observation of soil moisture. Remote measurements from space afford the possibility of obtaining frequent, global sampling of soil moisture over a large fraction of the Earth's land surface. Microwave measurements have the benefit of being largely unaffected by cloud cover and variable surface solar illumination, but accurate soil moisture estimates are limited to regions that have either bare soil or low to moderate amounts of vegetation cover. A particular advantage of passive microwave sensors is that in the absence of significant vegetation cover soil moisture is the dominant effect on the received signal. The spatial resolutions of passive Microwave soil moisture sensors currently considered for space operation are in the range 10-20 km. The most useful frequency range for soil moisture sensing is 1-5 GHz. System design considerations include optimum choice of frequencies, polarizations, and scanning configurations, based on trade-offs between requirements for high vegetation penetration capability, freedom from electromagnetic interference, manageable antenna size and complexity, and the requirement that a sufficient number of information channels be available to correct for perturbing geophysical effects. This paper outlines the basic principles of the passive microwave technique for soil moisture sensing, and reviews briefly the status of current retrieval methods. Particularly promising are methods for optimally assimilating passive microwave data into hydrologic models. Further studies are needed to investigate the effects on microwave observations of within-footprint spatial heterogeneity of vegetation cover and subsurface soil characteristics, and to assess the limitations imposed by heterogeneity on the retrievability of large-scale soil moisture information from remote observations.

Surface folding-induced attraction and motion of particles in a soft elastic gel: cooperative effects of surface tension, elasticity, and gravity.

PubMed

Chakrabarti, Aditi; Chaudhury, Manoj K

2013-12-17

We report some experimental observations regarding a new type of long-range interaction between rigid particles that prevails when they are suspended in an ultrasoft elastic gel. A denser particle submerges itself to a considerable depth inside the gel and becomes elasto-buoyant by balancing its weight against the elastic force exerted by the surrounding medium. By virtue of a large elasto-capillary length, the surface of the gel wraps around the particle and closes to create a line singularity connecting the particle to the free surface of the gel. A substantial amount of tensile strain is thus developed in the gel network parallel to the free surface that penetrates to a significant depth inside the gel. The field of this tensile strain is rather long-range because of a large gravito-elastic correlation length and sufficiently strong to pull two submerged particles into contact. The particles move toward each other with an effective force following an inverse linear distance law. When more monomers or dimers of the particles are released inside the gel, they orient rather freely inside the capsules where they are located and attract each other to form closely packed clusters. Eventually, these clusters themselves interact and coalesce. This is an emergent phenomenon in which gravity, capillarity, and elasticity work in tandem to create a long-range interaction. We also present the results of a related experiment, in which a particle suspended inside a thickness-graded gel moves accompanied by the continuous folding and the relaxation of the gel's surface.

Modeling and test of a kinaesthetic actuator based on MR fluid for haptic applications.

PubMed

Yang, Tae-Heon; Koo, Jeong-Hoi; Kim, Sang-Youn; Kwon, Dong-Soo

2017-03-01

Haptic display units have been widely used for conveying button sensations to users, primarily employing vibrotactile actuators. However, the human feeling for pressing buttons mainly relies on kinaesthetic sensations (rather than vibrotactile sensations), and little studies exist on small-scale kinaesthetic haptic units. Thus, the primary goals of this paper are to design a miniature kinaesthetic actuator based on Magneto-Rheological (MR) fluid that can convey various button-clicking sensations and to experimentally evaluate its haptic performance. The design focuses of the proposed actuator were to produce sufficiently large actuation forces (resistive forces) for human users in a given size constraint and to offer a wide range of actuation forces for conveying vivid haptic sensations to users. To this end, this study first performed a series of parametric studies using mathematical force models for multiple operating modes of MR fluid in conjunction with finite element electromagnetism analysis. After selecting design parameters based on parametric studies, a prototype actuator was constructed, and its performance was evaluated using a dynamic mechanical analyzer. It measured the actuator's resistive force with a varying stroke (pressed depth) up to 1 mm and a varying input current from 0 A to 200 mA. The results show that the proposed actuator creates a wide range of resistive forces from around 2 N (off-state) to over 9.5 N at 200 mA. In order to assess the prototype's performance in the terms of the haptic application prospective, a maximum force rate was calculated to determine just noticeable difference in force changes for the 1 mm stoke of the actuator. The results show that the force rate is sufficient to mimic various levels of button sensations, indicating that the proposed kinaesthetic actuator can offer a wide range of resistive force changes that can be conveyed to human operators.

Serum zinc concentration in cystic fibrosis patients with CFTR I1234V mutation associated with pancreatic sufficiency.

PubMed

AbdulWahab, Atqah; Abushahin, Ahmed; Allangawi, Mona; Chandra, Prem; Abdel Rahman, Mohamed Osman; Soliman, Ashraf

2017-05-01

To determine serum zinc (Zn) level among cystic fibrosis (CF) patients with homozygous CFTR I1234V mutation associated with pancreatic sufficiency (PS). A cross-sectional study was conducted including both pediatric and adult CF patients. Data on age, weight, height, body mass index (BMI), BMI Z-score, FEV1, and chronic Pseudomonas aeruginosa infection were collected. Serum Zn, albumin, and total proteins were measured and analyzed. Forty-five CF patients with homozygous CFTR I1234V mutation belonging to a large Arab kindred tribe and eight CF patients with other mutations associated with pancreatic insufficiency (PI). Patient's age ranged from 2 to 49 years with a mean age of 15.1 ± 9.1 years and mean plasma Zn of 0.78 ± 0.15 mcg/mL. Seven (13.2%) patients with CFTR I1234V and PS had low Zn levels (<0.6 mcg/mL). Mean age among Zn deficient group was significantly older. The mean FEV1 in the deficient group was found to be insignificant low. Persistent P. aeruginosa colonization was more prevalent in Zn deficient group. BMI Z-scosre of CF patients were positively correlated with Zn levels. Forty-five healthy subjects belonging to the same Arab tribe were selected in order to assess their Zn levels and their mean plasma Zn of 0.84 ± 0.11 mcg/mL (range 0.65-1.1 mcg/mL) with mean age 20.4 ± 10.1 years (range 6-40 years). These findings suggest that Zn deficiency can occur in CF patients with PS. The association of Zn levels and the frequency of P. aeruginosa isolated in CF patients need further investigation. © 2015 The Authors. The Clinical Respiratory Journal Published by John Wiley & Sons Ltd.

The effect of viscoelasticity on the stability of a pulmonary airway liquid layer

NASA Astrophysics Data System (ADS)

Halpern, David; Fujioka, Hideki; Grotberg, James B.

2010-01-01

The lungs consist of a network of bifurcating airways that are lined with a thin liquid film. This film is a bilayer consisting of a mucus layer on top of a periciliary fluid layer. Mucus is a non-Newtonian fluid possessing viscoelastic characteristics. Surface tension induces flows within the layer, which may cause the lung's airways to close due to liquid plug formation if the liquid film is sufficiently thick. The stability of the liquid layer is also influenced by the viscoelastic nature of the liquid, which is modeled using the Oldroyd-B constitutive equation or as a Jeffreys fluid. To examine the role of mucus alone, a single layer of a viscoelastic fluid is considered. A system of nonlinear evolution equations is derived using lubrication theory for the film thickness and the film flow rate. A uniform film is initially perturbed and a normal mode analysis is carried out that shows that the growth rate g for a viscoelastic layer is larger than for a Newtonian fluid with the same viscosity. Closure occurs if the minimum core radius, Rmin(t), reaches zero within one breath. Solutions of the nonlinear evolution equations reveal that Rmin normally decreases to zero faster with increasing relaxation time parameter, the Weissenberg number We. For small values of the dimensionless film thickness parameter ɛ, the closure time, tc, increases slightly with We, while for moderate values of ɛ, ranging from 14% to 18% of the tube radius, tc decreases rapidly with We provided the solvent viscosity is sufficiently small. Viscoelasticity was found to have little effect for ɛ >0.18, indicating the strong influence of surface tension. The film thickness parameter ɛ and the Weissenberg number We also have a significant effect on the maximum shear stress on tube wall, max(τw), and thus, potentially, an impact on cell damage. Max(τw) increases with ɛ for fixed We, and it decreases with increasing We for small We provided the solvent viscosity parameter is sufficiently small. For large ɛ ≈0.2, there is no significant difference between the Newtonian flow case and the large We cases.

Technical Note: Range verification system using edge detection method for a scintillator and a CCD camera system.

PubMed

Saotome, Naoya; Furukawa, Takuji; Hara, Yousuke; Mizushima, Kota; Tansho, Ryohei; Saraya, Yuichi; Shirai, Toshiyuki; Noda, Koji

2016-04-01

Three-dimensional irradiation with a scanned carbon-ion beam has been performed from 2011 at the authors' facility. The authors have developed the rotating-gantry equipped with the scanning irradiation system. The number of combinations of beam properties to measure for the commissioning is more than 7200, i.e., 201 energy steps, 3 intensities, and 12 gantry angles. To compress the commissioning time, quick and simple range verification system is required. In this work, the authors develop a quick range verification system using scintillator and charge-coupled device (CCD) camera and estimate the accuracy of the range verification. A cylindrical plastic scintillator block and a CCD camera were installed on the black box. The optical spatial resolution of the system is 0.2 mm/pixel. The camera control system was connected and communicates with the measurement system that is part of the scanning system. The range was determined by image processing. Reference range for each energy beam was determined by a difference of Gaussian (DOG) method and the 80% of distal dose of the depth-dose distribution that were measured by a large parallel-plate ionization chamber. The authors compared a threshold method and a DOG method. The authors found that the edge detection method (i.e., the DOG method) is best for the range detection. The accuracy of range detection using this system is within 0.2 mm, and the reproducibility of the same energy measurement is within 0.1 mm without setup error. The results of this study demonstrate that the authors' range check system is capable of quick and easy range verification with sufficient accuracy.

Technical Note: Range verification system using edge detection method for a scintillator and a CCD camera system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saotome, Naoya, E-mail: naosao@nirs.go.jp; Furukawa, Takuji; Hara, Yousuke

Purpose: Three-dimensional irradiation with a scanned carbon-ion beam has been performed from 2011 at the authors’ facility. The authors have developed the rotating-gantry equipped with the scanning irradiation system. The number of combinations of beam properties to measure for the commissioning is more than 7200, i.e., 201 energy steps, 3 intensities, and 12 gantry angles. To compress the commissioning time, quick and simple range verification system is required. In this work, the authors develop a quick range verification system using scintillator and charge-coupled device (CCD) camera and estimate the accuracy of the range verification. Methods: A cylindrical plastic scintillator blockmore » and a CCD camera were installed on the black box. The optical spatial resolution of the system is 0.2 mm/pixel. The camera control system was connected and communicates with the measurement system that is part of the scanning system. The range was determined by image processing. Reference range for each energy beam was determined by a difference of Gaussian (DOG) method and the 80% of distal dose of the depth-dose distribution that were measured by a large parallel-plate ionization chamber. The authors compared a threshold method and a DOG method. Results: The authors found that the edge detection method (i.e., the DOG method) is best for the range detection. The accuracy of range detection using this system is within 0.2 mm, and the reproducibility of the same energy measurement is within 0.1 mm without setup error. Conclusions: The results of this study demonstrate that the authors’ range check system is capable of quick and easy range verification with sufficient accuracy.« less

Efficient high-throughput sequencing of a laser microdissected chromosome arm

PubMed Central

2013-01-01

Background Genomic sequence assemblies are key tools for a broad range of gene function and evolutionary studies. The diploid amphibian Xenopus tropicalis plays a pivotal role in these fields due to its combination of experimental flexibility, diploid genome, and early-branching tetrapod taxonomic position, having diverged from the amniote lineage ~360 million years ago. A genome assembly and a genetic linkage map have recently been made available. Unfortunately, large gaps in the linkage map attenuate long-range integrity of the genome assembly. Results We laser dissected the short arm of X. tropicalis chromosome 7 for next generation sequencing and computational mapping to the reference genome. This arm is of particular interest as it encodes the sex determination locus, but its genetic map contains large gaps which undermine available genome assemblies. Whole genome amplification of 15 laser-microdissected 7p arms followed by next generation sequencing yielded ~35 million reads, over four million of which uniquely mapped to the X. tropicalis genome. Our analysis placed more than 200 previously unmapped scaffolds on the analyzed chromosome arm, providing valuable low-resolution physical map information for de novo genome assembly. Conclusion We present a new approach for improving and validating genetic maps and sequence assemblies. Whole genome amplification of 15 microdissected chromosome arms provided sufficient high-quality material for localizing previously unmapped scaffolds and genes as well as recognizing mislocalized scaffolds. PMID:23714049

Zoonotic Babesia microti in the northeastern U.S.: Evidence for the expansion of a specific parasite lineage

PubMed Central

Molloy, Philip; Weeks, Karen

2018-01-01

The recent range expansion of human babesiosis in the northeastern United States, once found only in restricted coastal sites, is not well understood. This study sought to utilize a large number of samples to examine the population structure of the parasites on a fine scale to provide insights into the mode of emergence across the region. 228 B. microti samples collected in endemic northeastern U.S. sites were genotyped using published Variable number tandem repeat (VNTR) markers. The genetic diversity and population structure were analysed on a geographic scale using Phyloviz and TESS, programs that utilize two different methods to identify population membership without predefined population data. Three distinct populations were detected in northeastern US, each dominated by a single ancestral type. In contrast to the limited range of the Nantucket and Cape Cod populations, the mainland population dominated from New Jersey eastward to Boston. Ancestral populations of B. microti were sufficiently isolated to differentiate into distinct populations. Despite this, a single population was detected across a large geographic area of the northeast that historically had at least 3 distinct foci of transmission, central New Jersey, Long Island and southeastern Connecticut. We conclude that a single B. microti genotype has expanded across the northeastern U.S. The biological attributes associated with this parasite genotype that have contributed to such a selective sweep remain to be identified. PMID:29565993

Implementation and Assessment of Advanced Analog Vector-Matrix Processor

NASA Technical Reports Server (NTRS)

Gary, Charles K.; Bualat, Maria G.; Lum, Henry, Jr. (Technical Monitor)

1994-01-01

This paper discusses the design and implementation of an analog optical vecto-rmatrix coprocessor with a throughput of 128 Mops for a personal computer. Vector matrix calculations are inherently parallel, providing a promising domain for the use of optical calculators. However, to date, digital optical systems have proven too cumbersome to replace electronics, and analog processors have not demonstrated sufficient accuracy in large scale systems. The goal of the work described in this paper is to demonstrate a viable optical coprocessor for linear operations. The analog optical processor presented has been integrated with a personal computer to provide full functionality and is the first demonstration of an optical linear algebra processor with a throughput greater than 100 Mops. The optical vector matrix processor consists of a laser diode source, an acoustooptical modulator array to input the vector information, a liquid crystal spatial light modulator to input the matrix information, an avalanche photodiode array to read out the result vector of the vector matrix multiplication, as well as transport optics and the electronics necessary to drive the optical modulators and interface to the computer. The intent of this research is to provide a low cost, highly energy efficient coprocessor for linear operations. Measurements of the analog accuracy of the processor performing 128 Mops are presented along with an assessment of the implications for future systems. A range of noise sources, including cross-talk, source amplitude fluctuations, shot noise at the detector, and non-linearities of the optoelectronic components are measured and compared to determine the most significant source of error. The possibilities for reducing these sources of error are discussed. Also, the total error is compared with that expected from a statistical analysis of the individual components and their relation to the vector-matrix operation. The sufficiency of the measured accuracy of the processor is compared with that required for a range of typical problems. Calculations resolving alloy concentrations from spectral plume data of rocket engines are implemented on the optical processor, demonstrating its sufficiency for this problem. We also show how this technology can be easily extended to a 100 x 100 10 MHz (200 Cops) processor.

Reentrant equilibrium disordering in nanoparticle–polymer mixtures

DOE PAGES

Meng, Dong; Kumar, Sanat K.; Grest, Gary S.; ...

2017-01-31

A large body of experimental work has established that athermal colloid/polymer mixtures undergo a sequence of transitions from a disordered fluid state to a colloidal crystal to a second disordered phase with increasing polymer concentration. These transitions are driven by polymer-mediated interparticle attraction, which is a function of both the polymer density and size. It has been posited that the disordered state at high polymer density is a consequence of strong interparticle attractions that kinetically inhibit the formation of the colloidal crystal, i.e., the formation of a non-equilibrium gel phase interferes with crystallization. Here we use molecular dynamics simulations andmore » density functional theory on polymers and nanoparticles (NPs) of comparable size and show that the crystal-disordered phase coexistence at high polymer density for sufficiently long chains corresponds to an equilibrium thermodynamic phase transition. While the crystal is, indeed, stabilized at intermediate polymer density by polymer-induced intercolloid attractions, it is destabilized at higher densities because long chains lose significant configurational entropy when they are forced to occupy all of the crystal voids. Finally, our results are in quantitative agreement with existing experimental data and show that, at least in the nanoparticle limit of sufficiently small colloidal particles, the crystal phase only has a modest range of thermodynamic stability.« less

DEVELOPMENT OF STANDARDIZED LARGE RIVER BIOASSESSMENT PROTOCOLS (LR-BP) FOR BENTHIC MACROINVERTEBRATE ASSEMBLAGES

EPA Science Inventory

We conducted research comparing several methods currently in use for the bioassessment and monitoring of fish and benthic macroinvertebrate assemblages of large rivers. Fish data demonstrate that electrofishing 1000 m of shoreline is sufficient for bioassessments on boatable riv...

Computational domain length and Reynolds number effects on large-scale coherent motions in turbulent pipe flow

NASA Astrophysics Data System (ADS)

Feldmann, Daniel; Bauer, Christian; Wagner, Claus

2018-03-01

We present results from direct numerical simulations (DNS) of turbulent pipe flow at shear Reynolds numbers up to Reτ = 1500 using different computational domains with lengths up to ?. The objectives are to analyse the effect of the finite size of the periodic pipe domain on large flow structures in dependency of Reτ and to assess a minimum ? required for relevant turbulent scales to be captured and a minimum Reτ for very large-scale motions (VLSM) to be analysed. Analysing one-point statistics revealed that the mean velocity profile is invariant for ?. The wall-normal location at which deviations occur in shorter domains changes strongly with increasing Reτ from the near-wall region to the outer layer, where VLSM are believed to live. The root mean square velocity profiles exhibit domain length dependencies for pipes shorter than 14R and 7R depending on Reτ. For all Reτ, the higher-order statistical moments show only weak dependencies and only for the shortest domain considered here. However, the analysis of one- and two-dimensional pre-multiplied energy spectra revealed that even for larger ?, not all physically relevant scales are fully captured, even though the aforementioned statistics are in good agreement with the literature. We found ? to be sufficiently large to capture VLSM-relevant turbulent scales in the considered range of Reτ based on our definition of an integral energy threshold of 10%. The requirement to capture at least 1/10 of the global maximum energy level is justified by a 14% increase of the streamwise turbulence intensity in the outer region between Reτ = 720 and 1500, which can be related to VLSM-relevant length scales. Based on this scaling anomaly, we found Reτ⪆1500 to be a necessary minimum requirement to investigate VLSM-related effects in pipe flow, even though the streamwise energy spectra does not yet indicate sufficient scale separation between the most energetic and the very long motions.

Spatially-explicit estimation of geographical representation in large-scale species distribution datasets.

PubMed

Kalwij, Jesse M; Robertson, Mark P; Ronk, Argo; Zobel, Martin; Pärtel, Meelis

2014-01-01

Much ecological research relies on existing multispecies distribution datasets. Such datasets, however, can vary considerably in quality, extent, resolution or taxonomic coverage. We provide a framework for a spatially-explicit evaluation of geographical representation within large-scale species distribution datasets, using the comparison of an occurrence atlas with a range atlas dataset as a working example. Specifically, we compared occurrence maps for 3773 taxa from the widely-used Atlas Florae Europaeae (AFE) with digitised range maps for 2049 taxa of the lesser-known Atlas of North European Vascular Plants. We calculated the level of agreement at a 50-km spatial resolution using average latitudinal and longitudinal species range, and area of occupancy. Agreement in species distribution was calculated and mapped using Jaccard similarity index and a reduced major axis (RMA) regression analysis of species richness between the entire atlases (5221 taxa in total) and between co-occurring species (601 taxa). We found no difference in distribution ranges or in the area of occupancy frequency distribution, indicating that atlases were sufficiently overlapping for a valid comparison. The similarity index map showed high levels of agreement for central, western, and northern Europe. The RMA regression confirmed that geographical representation of AFE was low in areas with a sparse data recording history (e.g., Russia, Belarus and the Ukraine). For co-occurring species in south-eastern Europe, however, the Atlas of North European Vascular Plants showed remarkably higher richness estimations. Geographical representation of atlas data can be much more heterogeneous than often assumed. Level of agreement between datasets can be used to evaluate geographical representation within datasets. Merging atlases into a single dataset is worthwhile in spite of methodological differences, and helps to fill gaps in our knowledge of species distribution ranges. Species distribution dataset mergers, such as the one exemplified here, can serve as a baseline towards comprehensive species distribution datasets.

Development of ground-water supplies at Mississippi test facility, Hancock County, Mississippi

USGS Publications Warehouse

Newcome, Roy

1967-01-01

Potable and industrial water supplies at the National Aeronautics and Space Administration's Mississippi Test Facility in Hancock County, Miss., are obtained from large-capacity wells that tap southward-dipping water-bearing sands of Miocene and Pliocene age. The fresh-water-bearing section is 2,000-3,000 feet thick in the area, and individual aquifers are as thick as 450 feet. Aquifer thickness is not constant over large areas, however; and 100 feet is a more common thickness. Three wells installed for potable water supply are 1,434-1,524 feet deep and have produced 1,100-2,500 gpm (gallons per minute) by natural flow. Artesian pressure is sufficient to provide a static head as high as 90 feet above land surface. Planned use rate for two of the wells is about 600 gpm each and for the third, 1,250 gpm. Water for cooling Saturn rocket test-stand deflectors is obtained from three wells 1,873, 1,695, and 672 feet deep. The production rates of these wells are 3,100, 4,500, and 5,000 gpm, respectively; the wells are capable of supplying 7.5 million gallons in a 10-hour period (18 million gallons per day). Artesian head for the aquifers tapped by these wells ranges from 104 feet above land surface for the deepest aquifer to 15 feet for the shallowest. Aquifer transmissibilities determined in pumping tests range from 81,000 to 200,000 gallons per day per foot. Specific capacities of the wells range from a 15 to 47 gpm per foot of drawdown. Water from the supply wells is soft and of good quality. Dissolved solids range from 236 to 315 parts per million. The water is a sodium bicarbonate type, with high pH. The concentration of iron is less than 0.3 part per million. Water temperatures range from 79?F in the shallowest supply well to 100?F in the deepest.

Si3N4 Optomechanical Crystals in the Resolved-sideband Regime

DTIC Science & Technology

2014-01-27

between cavity photons and phonons was used to demon- strate electromagnetically induced transparency ( EIT ) mediated by a mechanical resonance; radiation...wavelength range. The sideband resolution achieved was sufficient for observing, at room temperature and atmos- pheric pressure, EIT mediated by a 4 GHz...sufficient for the observation of optomechanical EIT at room tempera- ture and atmospheric pressure. This effect corresponds to the creation of a narrow

Robust Optimal Adaptive Control Method with Large Adaptive Gain

NASA Technical Reports Server (NTRS)

Nguyen, Nhan T.

2009-01-01

In the presence of large uncertainties, a control system needs to be able to adapt rapidly to regain performance. Fast adaptation is referred to the implementation of adaptive control with a large adaptive gain to reduce the tracking error rapidly. However, a large adaptive gain can lead to high-frequency oscillations which can adversely affect robustness of an adaptive control law. A new adaptive control modification is presented that can achieve robust adaptation with a large adaptive gain without incurring high-frequency oscillations as with the standard model-reference adaptive control. The modification is based on the minimization of the Y2 norm of the tracking error, which is formulated as an optimal control problem. The optimality condition is used to derive the modification using the gradient method. The optimal control modification results in a stable adaptation and allows a large adaptive gain to be used for better tracking while providing sufficient stability robustness. Simulations were conducted for a damaged generic transport aircraft with both standard adaptive control and the adaptive optimal control modification technique. The results demonstrate the effectiveness of the proposed modification in tracking a reference model while maintaining a sufficient time delay margin.

Mechanism of explosive eruptions of Kilauea Volcano, Hawaii

USGS Publications Warehouse

Dvorak, J.J.

1992-01-01

A small explosive eruption of Kilauea Volcano, Hawaii, occurred in May 1924. The eruption was preceded by rapid draining of a lava lake and transfer of a large volume of magma from the summit reservoir to the east rift zone. This lowered the magma column, which reduced hydrostatic pressure beneath Halemaumau and allowed groundwater to flow rapidly into areas of hot rock, producing a phreatic eruption. A comparison with other events at Kilauea shows that the transfer of a large volume of magma out of the summit reservoir is not sufficient to produce a phreatic eruption. For example, the volume transferred at the beginning of explosive activity in May 1924 was less than the volumes transferred in March 1955 and January-February 1960, when no explosive activity occurred. Likewise, draining of a lava lake and deepening of the floor of Halemaumau, which occurred in May 1922 and August 1923, were not sufficient to produce explosive activity. A phreatic eruption of Kilauea requires both the transfer of a large volume of magma from the summit reservoir and the rapid removal of magma from near the surface, where the surrounding rocks have been heated to a sufficient temperature to produce steam explosions when suddenly contacted by groundwater. ?? 1992 Springer-Verlag.

AlInAsSb/GaSb staircase avalanche photodiode

NASA Astrophysics Data System (ADS)

Ren, Min; Maddox, Scott; Chen, Yaojia; Woodson, Madison; Campbell, Joe C.; Bank, Seth

2016-02-01

Over 30 years ago, Capasso and co-workers [IEEE Trans. Electron Devices 30, 381 (1982)] proposed the staircase avalanche photodetector (APD) as a solid-state analog of the photomultiplier tube. In this structure, electron multiplication occurs deterministically at steps in the conduction band profile, which function as the dynodes of a photomultiplier tube, leading to low excess multiplication noise. Unlike traditional APDs, the origin of staircase gain is band engineering rather than large applied electric fields. Unfortunately, the materials available at the time, principally AlxGa1-xAs/GaAs, did not offer sufficiently large conduction band offsets and energy separations between the direct and indirect valleys to realize the full potential of the staircase gain mechanism. Here, we report a true staircase APD operation using alloys of a rather underexplored material, AlxIn1-xAsySb1-y, lattice-matched to GaSb. Single step "staircase" devices exhibited a constant gain of ˜2×, over a broad range of applied bias, operating temperature, and excitation wavelengths/intensities, consistent with Monte Carlo calculations.

Experimental estimation of transmissibility matrices for industrial multi-axis vibration isolation systems

NASA Astrophysics Data System (ADS)

Beijen, Michiel A.; Voorhoeve, Robbert; Heertjes, Marcel F.; Oomen, Tom

2018-07-01

Vibration isolation is essential for industrial high-precision systems to suppress external disturbances. The aim of this paper is to develop a general identification approach to estimate the frequency response function (FRF) of the transmissibility matrix, which is a key performance indicator for vibration isolation systems. The major challenge lies in obtaining a good signal-to-noise ratio in view of a large system weight. A non-parametric system identification method is proposed that combines floor and shaker excitations. Furthermore, a method is presented to analyze the input power spectrum of the floor excitations, both in terms of magnitude and direction. In turn, the input design of the shaker excitation signals is investigated to obtain sufficient excitation power in all directions with minimum experiment cost. The proposed methods are shown to provide an accurate FRF of the transmissibility matrix in three relevant directions on an industrial active vibration isolation system over a large frequency range. This demonstrates that, despite their heavy weight, industrial vibration isolation systems can be accurately identified using this approach.

High Throughput, Label-free Screening Small Molecule Compound Libraries for Protein-Ligands using Combination of Small Molecule Microarrays and a Special Ellipsometry-based Optical Scanner.

PubMed

Landry, James P; Fei, Yiyan; Zhu, X D

2011-12-01

Small-molecule compounds remain the major source of therapeutic and preventative drugs. Developing new drugs against a protein target often requires screening large collections of compounds with diverse structures for ligands or ligand fragments that exhibit sufficiently affinity and desirable inhibition effect on the target before further optimization and development. Since the number of small molecule compounds is large, high-throughput screening (HTS) methods are needed. Small-molecule microarrays (SMM) on a solid support in combination with a suitable binding assay form a viable HTS platform. We demonstrate that by combining an oblique-incidence reflectivity difference optical scanner with SMM we can screen 10,000 small-molecule compounds on a single glass slide for protein ligands without fluorescence labeling. Furthermore using such a label-free assay platform we can simultaneously acquire binding curves of a solution-phase protein to over 10,000 immobilized compounds, thus enabling full characterization of protein-ligand interactions over a wide range of affinity constants.

Markov modeling of peptide folding in the presence of protein crowders

NASA Astrophysics Data System (ADS)

Nilsson, Daniel; Mohanty, Sandipan; Irbäck, Anders

2018-02-01

We use Markov state models (MSMs) to analyze the dynamics of a β-hairpin-forming peptide in Monte Carlo (MC) simulations with interacting protein crowders, for two different types of crowder proteins [bovine pancreatic trypsin inhibitor (BPTI) and GB1]. In these systems, at the temperature used, the peptide can be folded or unfolded and bound or unbound to crowder molecules. Four or five major free-energy minima can be identified. To estimate the dominant MC relaxation times of the peptide, we build MSMs using a range of different time resolutions or lag times. We show that stable relaxation-time estimates can be obtained from the MSM eigenfunctions through fits to autocorrelation data. The eigenfunctions remain sufficiently accurate to permit stable relaxation-time estimation down to small lag times, at which point simple estimates based on the corresponding eigenvalues have large systematic uncertainties. The presence of the crowders has a stabilizing effect on the peptide, especially with BPTI crowders, which can be attributed to a reduced unfolding rate ku, while the folding rate kf is left largely unchanged.

Automatic generation of smart earthquake-resistant building system: Hybrid system of base-isolation and building-connection.

PubMed

Kasagi, M; Fujita, K; Tsuji, M; Takewaki, I

2016-02-01

A base-isolated building may sometimes exhibit an undesirable large response to a long-duration, long-period earthquake ground motion and a connected building system without base-isolation may show a large response to a near-fault (rather high-frequency) earthquake ground motion. To overcome both deficiencies, a new hybrid control system of base-isolation and building-connection is proposed and investigated. In this new hybrid building system, a base-isolated building is connected to a stiffer free wall with oil dampers. It has been demonstrated in a preliminary research that the proposed hybrid system is effective both for near-fault (rather high-frequency) and long-duration, long-period earthquake ground motions and has sufficient redundancy and robustness for a broad range of earthquake ground motions.An automatic generation algorithm of this kind of smart structures of base-isolation and building-connection hybrid systems is presented in this paper. It is shown that, while the proposed algorithm does not work well in a building without the connecting-damper system, it works well in the proposed smart hybrid system with the connecting damper system.

Facile Recovery of Individual High-Molecular-Weight, Low-Copy-Number Natural Plasmids for Genomic Sequencing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, L.E.; Detter, C,; Barrie, K.

2006-06-01

Sequencing of the large (>50 kb), low-copy-number (<5 per cell) plasmids that mediate horizontal gene transfer has been hindered by the difficulty and expense of isolating DNA from individual plasmids of this class. We report here that a kit method previously devised for purification of bacterial artificial chromosomes (BACs) can be adapted for effective preparation of individual plasmids up to 220 kb from wild gram-negative and gram-positive bacteria. Individual plasmid DNA recovered from less than 10 ml of Escherichia coli, Staphylococcus, and Corynebacterium cultures was of sufficient quantity and quality for construction of highcoverage libraries, as shown by sequencing fivemore » native plasmids ranging in size from 30 kb to 94 kb. We also report recommendations for vector screening to optimize plasmid sequence assembly, preliminary annotation of novel plasmid genomes, and insights on mobile genetic element biology derived from these sequences. Adaptation of this BAC method for large plasmid isolation removes one major technical hurdle to expanding our knowledge of the natural plasmid gene pool.« less

Cutting work in thick section cryomicrotomy.

PubMed

Saubermann, A J; Riley, W D; Beeuwkes, R

1977-09-01

The forces during cryosectioning were measured using miniature strain gauges attached to a load cell fitted to the drive arm of the Porter-Blum MT-2 cryomicrotome. Work was calculated and the data normalized to a standard (1 mm X 1 mm X 0.5 micrometer) section. Thermal energy generated was also calculated. Five parameters were studied: cutting angle, thickness, temperature, hardness, and block shape. Force patterns could be divided into three major groups thought to represent cutting (Type I), large fracture planes greater than 10 micrometer in length (Type II), and small fracture planes less than 10 micrometer in length (Type III). Type I and Type II produced satisfactory sections. Work in cutting ranged from an average of 78.4 muJ to 568.8 muJ. Cutting angle and temperature had the greatest effect on sectioning. Heat generated would be sufficient to cause through-section melting for 0.5 micrometer thick sections assuming the worst possible case, namely that all heat went into the section without loss. Presence of a Type II pattern (large fracture pattern) is thought to be presumptive evidence against thawing.

Thermo-Electron Ballistic Coolers or Heaters

NASA Technical Reports Server (NTRS)

Choi, Sang H.

2003-01-01

Electronic heat-transfer devices of a proposed type would exploit some of the quantum-wire-like, pseudo-superconducting properties of single-wall carbon nanotubes or, optionally, room-temperature-superconducting polymers (RTSPs). The devices are denoted thermo-electron ballistic (TEB) coolers or heaters because one of the properties that they exploit is the totally or nearly ballistic (dissipation or scattering free) transport of electrons. This property is observed in RTSPs and carbon nanotubes that are free of material and geometric defects, except under conditions in which oscillatory electron motions become coupled with vibrations of the nanotubes. Another relevant property is the high number density of electrons passing through carbon nanotubes -- sufficient to sustain electron current densities as large as 100 MA/square cm. The combination of ballistic motion and large current density should make it possible for TEB devices to operate at low applied potentials while pumping heat at rates several orders of magnitude greater than those of thermoelectric devices. It may also enable them to operate with efficiency close to the Carnot limit. In addition, the proposed TEB devices are expected to operate over a wider temperature range

On the influence of additive and multiplicative noise on holes in dissipative systems.

PubMed

Descalzi, Orazio; Cartes, Carlos; Brand, Helmut R

2017-05-01

We investigate the influence of noise on deterministically stable holes in the cubic-quintic complex Ginzburg-Landau equation. Inspired by experimental possibilities, we specifically study two types of noise: additive noise delta-correlated in space and spatially homogeneous multiplicative noise on the formation of π-holes and 2π-holes. Our results include the following main features. For large enough additive noise, we always find a transition to the noisy version of the spatially homogeneous finite amplitude solution, while for sufficiently large multiplicative noise, a collapse occurs to the zero amplitude solution. The latter type of behavior, while unexpected deterministically, can be traced back to a characteristic feature of multiplicative noise; the zero solution acts as the analogue of an absorbing boundary: once trapped at zero, the system cannot escape. For 2π-holes, which exist deterministically over a fairly small range of values of subcriticality, one can induce a transition to a π-hole (for additive noise) or to a noise-sustained pulse (for multiplicative noise). This observation opens the possibility of noise-induced switching back and forth from and to 2π-holes.

Constitutive relations for determining the critical conditions for dynamic recrystallization behavior

NASA Astrophysics Data System (ADS)

Choe, J. I.

2016-04-01

A series mathematical model has been developed for the prediction of flow stress and microstructure evolution during the hot deformation of metals such as copper or austenitic steels with low stacking fault energies, involving features of both diffusional flow and dislocation motion. As the strain rate increases, multiple peaks on the stress-strain curve decrease. At a high strain rate, the stress rises to a single peak, while dynamic recrystallization causes an oscillatory behavior. At a low strain rate (when there is sufficient time for the recrystallizing grains to grow before they become saturated with high dislocation density with an increase in strain rate), the difference in stored stress between recrystallizing and old grains diminishes, resulting in reduced driving force for grain growth and rendering smaller grains in the alloy. The final average grain size at the steady stage (large strain) increases with a decrease in the strain rate. During large strain deformation, grain size reduction accompanying dislocation creep might be balanced by the grain growth at the border delimiting the ranges of realization (field boundary) of the dislocation-creep and diffusion-creep mechanisms.

Integrating anatomy and function for zebrafish circuit analysis.

PubMed

Arrenberg, Aristides B; Driever, Wolfgang

2013-01-01

Due to its transparency, virtually every brain structure of the larval zebrafish is accessible to light-based interrogation of circuit function. Advanced stimulation techniques allow the activation of optogenetic actuators at different resolution levels, and genetically encoded calcium indicators report the activity of a large proportion of neurons in the CNS. Large datasets result and need to be analyzed to identify cells that have specific properties-e.g., activity correlation to sensory stimulation or behavior. Advances in three-dimensional (3D) functional mapping in zebrafish are promising; however, the mere coordinates of implicated neurons are not sufficient. To comprehensively understand circuit function, these functional maps need to be placed into the proper context of morphological features and projection patterns, neurotransmitter phenotypes, and key anatomical landmarks. We discuss the prospect of merging functional and anatomical data in an integrated atlas from the perspective of our work on long-range dopaminergic neuromodulation and the oculomotor system. We propose that such a resource would help researchers to surpass current hurdles in circuit analysis to achieve an integrated understanding of anatomy and function.

Precise starshade stationkeeping and pointing with a Zernike wavefront sensor

NASA Astrophysics Data System (ADS)

Bottom, Michael; Martin, Stefan; Seubert, Carl; Cady, Eric; Zareh, Shannon Kian; Shaklan, Stuart

2017-09-01

Starshades, large occulters positioned tens of thousands of kilometers in front of space telescopes, offer one of the few paths to imaging and characterizing Earth-like extrasolar planets. However, for a starshade to generate a sufficiently dark shadow on the telescope, the two must be coaligned to just 1 meter laterally, even at these large separations. The principal challenge to achieving this level of control is in determining the position of the starshade with respect to the space telescope. In this paper, we present numerical simulations and laboratory results demonstrating that a Zernike wavefront sensor coupled to a WFIRST-type telescope is able to deliver the stationkeeping precision required, by measuring light outside of the science wavelengths. The sensor can determine the starshade lateral position to centimeter level in seconds of open shutter time for stars brighter than eighth magnitude, with a capture range of 10 meters. We discuss the potential for fast (ms) tip/tilt pointing control at the milli-arcsecond level by illuminating the sensor with a laser mounted on the starshade. Finally, we present early laboratory results.

Rare and low-frequency coding variants alter human adult height

PubMed Central

Marouli, Eirini; Graff, Mariaelisa; Medina-Gomez, Carolina; Lo, Ken Sin; Wood, Andrew R; Kjaer, Troels R; Fine, Rebecca S; Lu, Yingchang; Schurmann, Claudia; Highland, Heather M; Rüeger, Sina; Thorleifsson, Gudmar; Justice, Anne E; Lamparter, David; Stirrups, Kathleen E; Turcot, Valérie; Young, Kristin L; Winkler, Thomas W; Esko, Tõnu; Karaderi, Tugce; Locke, Adam E; Masca, Nicholas GD; Ng, Maggie CY; Mudgal, Poorva; Rivas, Manuel A; Vedantam, Sailaja; Mahajan, Anubha; Guo, Xiuqing; Abecasis, Goncalo; Aben, Katja K; Adair, Linda S; Alam, Dewan S; Albrecht, Eva; Allin, Kristine H; Allison, Matthew; Amouyel, Philippe; Appel, Emil V; Arveiler, Dominique; Asselbergs, Folkert W; Auer, Paul L; Balkau, Beverley; Banas, Bernhard; Bang, Lia E; Benn, Marianne; Bergmann, Sven; Bielak, Lawrence F; Blüher, Matthias; Boeing, Heiner; Boerwinkle, Eric; Böger, Carsten A; Bonnycastle, Lori L; Bork-Jensen, Jette; Bots, Michiel L; Bottinger, Erwin P; Bowden, Donald W; Brandslund, Ivan; Breen, Gerome; Brilliant, Murray H; Broer, Linda; Burt, Amber A; Butterworth, Adam S; Carey, David J; Caulfield, Mark J; Chambers, John C; Chasman, Daniel I; Chen, Yii-Der Ida; Chowdhury, Rajiv; Christensen, Cramer; Chu, Audrey Y; Cocca, Massimiliano; Collins, Francis S; Cook, James P; Corley, Janie; Galbany, Jordi Corominas; Cox, Amanda J; Cuellar-Partida, Gabriel; Danesh, John; Davies, Gail; de Bakker, Paul IW; de Borst, Gert J.; de Denus, Simon; de Groot, Mark CH; de Mutsert, Renée; Deary, Ian J; Dedoussis, George; Demerath, Ellen W; den Hollander, Anneke I; Dennis, Joe G; Di Angelantonio, Emanuele; Drenos, Fotios; Du, Mengmeng; Dunning, Alison M; Easton, Douglas F; Ebeling, Tapani; Edwards, Todd L; Ellinor, Patrick T; Elliott, Paul; Evangelou, Evangelos; Farmaki, Aliki-Eleni; Faul, Jessica D; Feitosa, Mary F; Feng, Shuang; Ferrannini, Ele; Ferrario, Marco M; Ferrieres, Jean; Florez, Jose C; Ford, Ian; Fornage, Myriam; Franks, Paul W; Frikke-Schmidt, Ruth; Galesloot, Tessel E; Gan, Wei; Gandin, Ilaria; Gasparini, Paolo; Giedraitis, Vilmantas; Giri, Ayush; Girotto, Giorgia; Gordon, Scott D; Gordon-Larsen, Penny; Gorski, Mathias; Grarup, Niels; Grove, Megan L.; Gudnason, Vilmundur; Gustafsson, Stefan; Hansen, Torben; Harris, Kathleen Mullan; Harris, Tamara B; Hattersley, Andrew T; Hayward, Caroline; He, Liang; Heid, Iris M; Heikkilä, Kauko; Helgeland, Øyvind; Hernesniemi, Jussi; Hewitt, Alex W; Hocking, Lynne J; Hollensted, Mette; Holmen, Oddgeir L; Hovingh, G. Kees; Howson, Joanna MM; Hoyng, Carel B; Huang, Paul L; Hveem, Kristian; Ikram, M. Arfan; Ingelsson, Erik; Jackson, Anne U; Jansson, Jan-Håkan; Jarvik, Gail P; Jensen, Gorm B; Jhun, Min A; Jia, Yucheng; Jiang, Xuejuan; Johansson, Stefan; Jørgensen, Marit E; Jørgensen, Torben; Jousilahti, Pekka; Jukema, J Wouter; Kahali, Bratati; Kahn, René S; Kähönen, Mika; Kamstrup, Pia R; Kanoni, Stavroula; Kaprio, Jaakko; Karaleftheri, Maria; Kardia, Sharon LR; Karpe, Fredrik; Kee, Frank; Keeman, Renske; Kiemeney, Lambertus A; Kitajima, Hidetoshi; Kluivers, Kirsten B; Kocher, Thomas; Komulainen, Pirjo; Kontto, Jukka; Kooner, Jaspal S; Kooperberg, Charles; Kovacs, Peter; Kriebel, Jennifer; Kuivaniemi, Helena; Küry, Sébastien; Kuusisto, Johanna; La Bianca, Martina; Laakso, Markku; Lakka, Timo A; Lange, Ethan M; Lange, Leslie A; Langefeld, Carl D; Langenberg, Claudia; Larson, Eric B; Lee, I-Te; Lehtimäki, Terho; Lewis, Cora E; Li, Huaixing; Li, Jin; Li-Gao, Ruifang; Lin, Honghuang; Lin, Li-An; Lin, Xu; Lind, Lars; Lindström, Jaana; Linneberg, Allan; Liu, Yeheng; Liu, Yongmei; Lophatananon, Artitaya; Luan, Jian'an; Lubitz, Steven A; Lyytikäinen, Leo-Pekka; Mackey, David A; Madden, Pamela AF; Manning, Alisa K; Männistö, Satu; Marenne, Gaëlle; Marten, Jonathan; Martin, Nicholas G; Mazul, Angela L; Meidtner, Karina; Metspalu, Andres; Mitchell, Paul; Mohlke, Karen L; Mook-Kanamori, Dennis O; Morgan, Anna; Morris, Andrew D; Morris, Andrew P; Müller-Nurasyid, Martina; Munroe, Patricia B; Nalls, Mike A; Nauck, Matthias; Nelson, Christopher P; Neville, Matt; Nielsen, Sune F; Nikus, Kjell; Njølstad, Pål R; Nordestgaard, Børge G; Ntalla, Ioanna; O'Connel, Jeffrey R; Oksa, Heikki; Loohuis, Loes M Olde; Ophoff, Roel A; Owen, Katharine R; Packard, Chris J; Padmanabhan, Sandosh; Palmer, Colin NA; Pasterkamp, Gerard; Patel, Aniruddh P; Pattie, Alison; Pedersen, Oluf; Peissig, Peggy L; Peloso, Gina M; Pennell, Craig E; Perola, Markus; Perry, James A; Perry, John R.B.; Person, Thomas N; Pirie, Ailith; Polasek, Ozren; Posthuma, Danielle; Raitakari, Olli T; Rasheed, Asif; Rauramaa, Rainer; Reilly, Dermot F; Reiner, Alex P; Renström, Frida; Ridker, Paul M; Rioux, John D; Robertson, Neil; Robino, Antonietta; Rolandsson, Olov; Rudan, Igor; Ruth, Katherine S; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J; Sandow, Kevin; Sapkota, Yadav; Sattar, Naveed; Schmidt, Marjanka K; Schreiner, Pamela J; Schulze, Matthias B; Scott, Robert A; Segura-Lepe, Marcelo P; Shah, Svati; Sim, Xueling; Sivapalaratnam, Suthesh; Small, Kerrin S; Smith, Albert Vernon; Smith, Jennifer A; Southam, Lorraine; Spector, Timothy D; Speliotes, Elizabeth K; Starr, John M; Steinthorsdottir, Valgerdur; Stringham, Heather M; Stumvoll, Michael; Surendran, Praveen; Hart, Leen M ‘t; Tansey, Katherine E; Tardif, Jean-Claude; Taylor, Kent D; Teumer, Alexander; Thompson, Deborah J; Thorsteinsdottir, Unnur; Thuesen, Betina H; Tönjes, Anke; Tromp, Gerard; Trompet, Stella; Tsafantakis, Emmanouil; Tuomilehto, Jaakko; Tybjaerg-Hansen, Anne; Tyrer, Jonathan P; Uher, Rudolf; Uitterlinden, André G; Ulivi, Sheila; van der Laan, Sander W; Van Der Leij, Andries R; van Duijn, Cornelia M; van Schoor, Natasja M; van Setten, Jessica; Varbo, Anette; Varga, Tibor V; Varma, Rohit; Edwards, Digna R Velez; Vermeulen, Sita H; Vestergaard, Henrik; Vitart, Veronique; Vogt, Thomas F; Vozzi, Diego; Walker, Mark; Wang, Feijie; Wang, Carol A; Wang, Shuai; Wang, Yiqin; Wareham, Nicholas J; Warren, Helen R; Wessel, Jennifer; Willems, Sara M; Wilson, James G; Witte, Daniel R; Woods, Michael O; Wu, Ying; Yaghootkar, Hanieh; Yao, Jie; Yao, Pang; Yerges-Armstrong, Laura M; Young, Robin; Zeggini, Eleftheria; Zhan, Xiaowei; Zhang, Weihua; Zhao, Jing Hua; Zhao, Wei; Zhao, Wei; Zheng, He; Zhou, Wei; Rotter, Jerome I; Boehnke, Michael; Kathiresan, Sekar; McCarthy, Mark I; Willer, Cristen J; Stefansson, Kari; Borecki, Ingrid B; Liu, Dajiang J; North, Kari E; Heard-Costa, Nancy L; Pers, Tune H; Lindgren, Cecilia M; Oxvig, Claus; Kutalik, Zoltán; Rivadeneira, Fernando; Loos, Ruth JF; Frayling, Timothy M; Hirschhorn, Joel N; Deloukas, Panos; Lettre, Guillaume

2016-01-01

Summary Height is a highly heritable, classic polygenic trait with ∼700 common associated variants identified so far through genome-wide association studies. Here, we report 83 height-associated coding variants with lower minor allele frequencies (range of 0.1-4.8%) and effects of up to 2 cm/allele (e.g. in IHH, STC2, AR and CRISPLD2), >10 times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (+1-2 cm/allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes mutated in monogenic growth disorders and highlight new biological candidates (e.g. ADAMTS3, IL11RA, NOX4) and pathways (e.g. proteoglycan/glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate to large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways. PMID:28146470

Optimization of Industrial Ozone Generation with Pulsed Power

NASA Astrophysics Data System (ADS)

Lopez, Jose; Guerrero, Daniel; Freilich, Alfred; Ramoino, Luca; Seton Hall University Team; Degremont Technologies-Ozonia Team

2013-09-01

Ozone (O3) is widely used for applications ranging from various industrial chemical synthesis processes to large-scale water treatment. The consequent surge in world-wide demand has brought about the requirement for ozone generation at the rate of several hundreds grams per kilowatt hour (g/kWh). For many years, ozone has been generated by means of dielectric barrier discharges (DBD), where a high-energy electric field between two electrodes separated by a dielectric and gap containing pure oxygen or air produce various microplasmas. The resultant microplasmas provide sufficient energy to dissociate the oxygen molecules while allowing the proper energetics channels for the formation of ozone. This presentation will review the current power schemes used for large-scale ozone generation and explore the use of high-voltage nanosecond pulses with reduced electric fields. The created microplasmas in a high reduced electric field are expected to be more efficient for ozone generation. This is confirmed with the current results of this work which observed that the efficiency of ozone generation increases by over eight time when the rise time and pulse duration are shortened. Department of Physics, South Orange, NJ, USA.

Small-scale behavior in distorted turbulent boundary layers at low Reynolds number

NASA Technical Reports Server (NTRS)

Saddoughi, Seyed G.

1994-01-01

During the last three years we have conducted high- and low-Reynolds-number experiments, including hot-wire measurements of the velocity fluctuations, in the test-section-ceiling boundary layer of the 80- by 120-foot Full-Scale Aerodynamics Facility at NASA Ames Research Center, to test the local-isotropy predictions of Kolmogorov's universal equilibrium theory. This hypothesis, which states that at sufficiently high Reynolds numbers the small-scale structures of turbulent motions are independent of large-scale structures and mean deformations, has been used in theoretical studies of turbulence and computational methods such as large-eddy simulation; however, its range of validity in shear flows has been a subject of controversy. The present experiments were planned to enhance our understanding of the local-isotropy hypothesis. Our experiments were divided into two sets. First, measurements were taken at different Reynolds numbers in a plane boundary layer, which is a 'simple' shear flow. Second, experiments were designed to address this question: will our criteria for the existence of local isotropy hold for 'complex' nonequilibrium flows in which extra rates of mean strain are added to the basic mean shear?

Low speed test of a high-bypass-ratio propulsion system with an asymmetric inlet designed for a tilt-nacelle V/STOL airplane

NASA Technical Reports Server (NTRS)

Syberg, J.

1978-01-01

A large scale model of a lift/cruise fan inlet designed for a tilt nacelle V/STOL airplane was tested with a high bypass ratio turbofan. Testing was conducted at low freestream velocities with inlet angles of attack ranging from 0 deg to 120 deg. The operating limits for the nacelle were found to be related to inlet boundary layer separation. Small separations originating in the inlet diffuser cause little or no performance degradation. However, at sufficiently severe freestream conditions the separation changes abruptly to a lip separation. This change is associated with a significant reduction in nacelle net thrust as well as a sharp increase in fan blade vibratory stresses. Consequently, the onset of lip separation is regarded as the nacelle operating limit. The test verified that the asymmetric inlet design will provide high performance and stable operation at the design forward speed and angle of attack conditions. At some of these, however, operation near the lower end of the design inlet airflow range is not feasible due to the occurrence of lip separation.

Lost in search: (Mal-)adaptation to probabilistic decision environments in children and adults.

PubMed

Betsch, Tilmann; Lehmann, Anne; Lindow, Stefanie; Lang, Anna; Schoemann, Martin

2016-02-01

Adaptive decision making in probabilistic environments requires individuals to use probabilities as weights in predecisional information searches and/or when making subsequent choices. Within a child-friendly computerized environment (Mousekids), we tracked 205 children's (105 children 5-6 years of age and 100 children 9-10 years of age) and 103 adults' (age range: 21-22 years) search behaviors and decisions under different probability dispersions (.17; .33, .83 vs. .50, .67, .83) and constraint conditions (instructions to limit search: yes vs. no). All age groups limited their depth of search when instructed to do so and when probability dispersion was high (range: .17-.83). Unlike adults, children failed to use probabilities as weights for their searches, which were largely not systematic. When examining choices, however, elementary school children (unlike preschoolers) systematically used probabilities as weights in their decisions. This suggests that an intuitive understanding of probabilities and the capacity to use them as weights during integration is not a sufficient condition for applying simple selective search strategies that place one's focus on weight distributions. PsycINFO Database Record (c) 2016 APA, all rights reserved.

Direct numerical simulation of turbulent plane Couette flow under neutral and stable stratification

NASA Astrophysics Data System (ADS)

Mortikov, Evgeny

2017-11-01

Direct numerical simulation (DNS) approach was used to study turbulence dynamics in plane Couette flow under conditions ranging from neutral stability to the case of extreme stable stratification, where intermittency is observed. Simulations were performed for Reynolds numbers, based on the channel height and relative wall speed, up to 2 ×105 . Using DNS data, which covers a wide range of stability conditions, parameterizations of pressure correlation terms used in second-order closure turbulence models are discussed. Particular attention is also paid to the sustainment of intermittent turbulence under strong stratification. Intermittent regime is found to be associated with the formation of secondary large-scale structures elongated in the spanwise direction, which define spatially confined alternating regions of laminar and turbulent flow. The spanwise length of this structures increases with the increase in the bulk Richardson number and defines and additional constraint on the computational box size. In this work DNS results are presented in extended computational domains, where the intermittent turbulence is sustained for sufficiently higher Richardson numbers than previously reported.

Analysis of nitrogen saturation potential in Rocky Mountain tundra and forest: implications for aquatic systems

USGS Publications Warehouse

Baron, Jill S.; Ojima, Dennis S.; Holland, Elisabeth A.; Parton, William J.

1994-01-01

We employed grass and forest versions of the CENTURY model under a range of N deposition values (0.02–1.60 g N m−2 y−1) to explore the possibility that high observed lake and stream N was due to terrestrial N saturation of alpine tundra and subalpine forest in Loch Vale Watershed, Rocky Mountain National Park, Colorado. Model results suggest that N is limiting to subalpine forest productivity, but that excess leachate from alpine tundra is sufficient to account for the current observed stream N. Tundra leachate, combined with N leached from exposed rock surfaces, produce high N loads in aquatic ecosystems above treeline in the Colorado Front Range. A combination of terrestrial leaching, large N inputs from snowmelt, high watershed gradients, rapid hydrologic flushing and lake turnover times, and possibly other nutrient limitations of aquatic organisms constrain high elevation lakes and streams from assimilating even small increases in atmospheric N. CENTURY model simulations further suggest that, while increased N deposition will worsen the situation, nitrogen saturation is an ongoing phenomenon.

Multispeed Prethermalization in Quantum Spin Models with Power-Law Decaying Interactions

NASA Astrophysics Data System (ADS)

Frérot, Irénée; Naldesi, Piero; Roscilde, Tommaso

2018-01-01

The relaxation of uniform quantum systems with finite-range interactions after a quench is generically driven by the ballistic propagation of long-lived quasiparticle excitations triggered by a sufficiently small quench. Here we investigate the case of long-range (1 /rα) interactions for a d -dimensional lattice spin model with uniaxial symmetry, and show that, in the regime d <α

Fall Velocities of Hydrometeors in the Atmosphere: Refinements to a Continuous Analytical Power Law.

NASA Astrophysics Data System (ADS)

Khvorostyanov, Vitaly I.; Curry, Judith A.

2005-12-01

This paper extends the previous research of the authors on the unified representation of fall velocities for both liquid and crystalline particles as a power law over the entire size range of hydrometeors observed in the atmosphere. The power-law coefficients are determined as continuous analytical functions of the Best or Reynolds number or of the particle size. Here, analytical expressions are formulated for the turbulent corrections to the Reynolds number and to the power-law coefficients that describe the continuous transition from the laminar to the turbulent flow around a falling particle. A simple analytical expression is found for the correction of fall velocities for temperature and pressure. These expressions and the resulting fall velocities are compared with observations and other calculations for a range of ice crystal habits and sizes. This approach provides a continuous analytical power-law description of the terminal velocities of liquid and crystalline hydrometeors with sufficiently high accuracy and can be directly used in bin-resolving models or incorporated into parameterizations for cloud- and large-scale models and remote sensing techniques.

Multispeed Prethermalization in Quantum Spin Models with Power-Law Decaying Interactions.

PubMed

Frérot, Irénée; Naldesi, Piero; Roscilde, Tommaso

2018-02-02

The relaxation of uniform quantum systems with finite-range interactions after a quench is generically driven by the ballistic propagation of long-lived quasiparticle excitations triggered by a sufficiently small quench. Here we investigate the case of long-range (1/r^{α}) interactions for a d-dimensional lattice spin model with uniaxial symmetry, and show that, in the regime d<α

Symptom-Based Controller Therapy: A New Paradigm for Asthma Management

PubMed Central

Divekar, Rohit; Ameredes, Bill T.; Calhoun, William J.

2013-01-01

Appropriate management of persistent asthma, according to US and international guidelines, requires daily use of controller medications, most generally, inhaled corticosteroids (ICS). This approach, although effective and well established, imposes burdens of treatment and side effects onto asthma patients. A growing body of evidence suggests that patients with persistent asthma need not be managed with daily ICS, but rather can use them on an intermittent basis, occasioned by the occurrence of symptoms sufficient to warrant treatment with a rescue inhaler. Large, randomized, controlled studies, over a range of asthma severity, and in a range of ages from pediatrics to adults, suggest that in well-selected patients, a symptom based approach to administering controller therapy may produce equivalent outcomes, while reducing exposure to ICS. The concept of providing anti-inflammatory treatment to the patient, at the time inflammation is developing, is termed ‘temporal personalization’. The evidence to date suggests that symptom-based controller therapy is broadly useful in selected asthma patients, and is a management approach that could be incorporated into US and international guidelines for asthma. PMID:23904098

Are "Habitable" Exoplanets Really Habitable? -A perspective from atmospheric loss

NASA Astrophysics Data System (ADS)

Dong, C.; Huang, Z.; Jin, M.; Lingam, M.; Ma, Y. J.; Toth, G.; van der Holst, B.; Airapetian, V.; Cohen, O.; Gombosi, T. I.

2017-12-01

In the last two decades, the field of exoplanets has witnessed a tremendous creative surge. Research in exoplanets now encompasses a wide range of fields ranging from astrophysics to heliophysics and atmospheric science. One of the primary objectives of studying exoplanets is to determine the criteria for habitability, and whether certain exoplanets meet these requirements. The classical definition of the Habitable Zone (HZ) is the region around a star where liquid water can exist on the planetary surface given sufficient atmospheric pressure. However, this definition largely ignores the impact of the stellar wind and stellar magnetic activity on the erosion of an exoplanet's atmosphere. Amongst the many factors that determine habitability, understanding the mechanisms of atmospheric loss is of paramount importance. We will discuss the impact of exoplanetary space weather on climate and habitability, which offers fresh insights concerning the habitability of exoplanets, especially those orbiting M-dwarfs, such as Proxima b and the TRAPPIST-1 system. For each case, we will demonstrate the importance of the exoplanetary space weather on atmospheric ion loss and habitability.

Movements and use of space by Mangrove Cuckoos (Coccyzus minor) in Florida, USA.

PubMed

Lloyd, John David

2017-01-01

I used radio-telemetry to track the movements of Mangrove Cuckoos ( Coccyzus minor ) captured in southwest Florida. Relatively little is known about the natural history of Mangrove Cuckoos, and my goal was to provide an initial description of how individuals use space, with a focus on the size and placement of home ranges. I captured and affixed VHF radio-transmitters to 32 individuals between 2012 and 2015, and obtained a sufficient number of relocations from 16 of them to estimate home-range boundaries and describe patterns of movement. Home-range area varied widely among individuals, but in general was roughly four times larger than expected based on the body size of Mangrove Cuckoos. The median core area (50% isopleth) of a home range was 42 ha (range: 9-91 ha), and the median overall home range (90% isopleth) was 128 ha (range: 28-319 ha). The median distance between estimated locations recorded on subsequent days was 298 m (95% CI [187 m-409 m]), but variation within and among individuals was substantial, and it was not uncommon to relocate individuals >1 km from their location on the previous day. Site fidelity by individual birds was low; although Mangrove Cuckoos were present year-round within the study area, I did not observe any individuals that remained on a single home range throughout the year. Although individual birds showed no evidence of avoiding anthropogenic edges, they did not incorporate developed areas into their daily movements and home ranges consisted almost entirely of mangrove forest. The persistence of the species in the study area depended on a network of conserved lands-mostly public, but some privately conserved land as well-because large patches of mangrove forest did not occur on tracts left unprotected from development.

SU-F-J-190: Time Resolved Range Measurement System Using Scintillator and CCD Camera for the Slow Beam Extraction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saotome, N; Furukawa, T; Mizushima, K

2016-06-15

Purpose: To investigate the time structure of the range, we have verified the rang shift due to the betatron tune shift with several synchrotron parameters. Methods: A cylindrical plastic scintillator block and a CCD camera were installed on the black box. Using image processing, the range was determined the 80 percent of distal dose of the depth light distribution. The root mean square error of the range measurement using the scintillator and CCD system is about 0.2 mm. Range measurement was performed at interval of 170 msec. The chromaticity of the synchrotron was changed in the range of plus ormore » minus 1% from reference chromaticity in this study. All of the particle inside the synchrotron ring were extracted with the output beam intensity 1.8×10{sup 8} and 5.0×10{sub 7} particle per sec. Results: The time strictures of the range were changed by changing of the chromaticity. The reproducibility of the measurement was sufficient to observe the time structures of the range. The range shift was depending on the number of the residual particle inside the synchrotron ring. Conclusion: In slow beam extraction for scanned carbon-ion therapy, the range shift is undesirable because it causes the dose uncertainty in the target. We introduced the time-resolved range measurement using scintillator and CCD system. The scintillator and CCD system have enabled to verify the range shift with sufficient spatial resolution and reproducibility.« less

Bubble propagation in Hele-Shaw channels with centred constrictions

NASA Astrophysics Data System (ADS)

Franco-Gómez, Andrés; Thompson, Alice B.; Hazel, Andrew L.; Juel, Anne

2018-04-01

We study the propagation of finite bubbles in a Hele-Shaw channel, where a centred occlusion (termed a rail) is introduced to provide a small axially uniform depth constriction. For bubbles wide enough to span the channel, the system’s behaviour is similar to that of semi-infinite fingers and a symmetric static solution is stable. Here, we focus on smaller bubbles, in which case the symmetric static solution is unstable and the static bubble is displaced towards one of the deeper regions of the channel on either side of the rail. Using a combination of experiments and numerical simulations of a depth-averaged model, we show that a bubble propagating axially due to a small imposed flow rate can be stabilised in a steady symmetric mode centred on the rail through a subtle interaction between stabilising viscous forces and destabilising surface tension forces. However, for sufficiently large capillary numbers Ca, the ratio of viscous to surface tension forces, viscous forces in turn become destabilising thus returning the bubble to an off-centred propagation regime. With decreasing bubble size, the range of Ca for which steady centred propagation is stable decreases, and eventually vanishes through the coalescence of two supercritical pitchfork bifurcations. The depth-averaged model is found to accurately predict all the steady modes of propagation observed experimentally, and provides a comprehensive picture of the underlying steady bifurcation structure. However, for sufficiently large imposed flow rates, we find that initially centred bubbles do not converge onto a steady mode of propagation. Instead they transiently explore weakly unstable steady modes, an evolution which results in their break-up and eventual settling into a steady propagating state of changed topology.

Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope.

PubMed

Porter, Joanne L; Sabatini, Selina; Manning, Jack; Tavanti, Michele; Galman, James L; Turner, Nicholas J; Flitsch, Sabine L

2018-06-01

Cytochrome P450 monooxygenases are able to catalyse a range of synthetically challenging reactions ranging from hydroxylation and demethylation to sulfoxidation and epoxidation. As such they have great potential for biocatalytic applications but are underutilised due to often-poor expression, stability and solubility in recombinant bacterial hosts. The use of self-sufficient P450 s with fused haem and reductase domains has already contributed heavily to improving catalytic efficiency and simplifying an otherwise more complex multi-component system of P450 and redox partners. Herein, we present a new addition to the class VII family with the cloning, sequencing and characterisation of the self-sufficient CYP116B62 Hal1 from Halomonas sp. NCIMB 172, the genome of which has not yet been sequenced. Hal1 exhibits high levels of expression in a recombinant E. coli host and can be utilised from cell lysate or used in purified form. Hal1 favours NADPH as electron donor and displays a diverse range of activities including hydroxylation, demethylation and sulfoxidation. These properties make Hal1 suitable for future biocatalytic applications or as a template for optimisation through engineering. Copyright © 2018 Elsevier Inc. All rights reserved.

Cybernetic principles of aging and rejuvenation: the buffering- challenging strategy for life extension.

PubMed

Heylighen, Francis

2014-01-01

Aging is analyzed as the spontaneous loss of adaptivity and increase in fragility that characterizes dynamic systems. Cybernetics defines the general regulatory mechanisms that a system can use to prevent or repair the damage produced by disturbances. According to the law of requisite variety, disturbances can be held in check by maximizing buffering capacity, range of compensatory actions, and knowledge about which action to apply to which disturbance. This suggests a general strategy for rejuvenating the organism by increasing its capabilities of adaptation. Buffering can be optimized by providing sufficient rest together with plenty of nutrients: amino acids, antioxidants, methyl donors, vitamins, minerals, etc. Knowledge and the range of action can be extended by subjecting the organism to an as large as possible variety of challenges. These challenges are ideally brief so as not to deplete resources and produce irreversible damage. However, they should be sufficiently intense and unpredictable to induce an overshoot in the mobilization of resources for damage repair, and to stimulate the organism to build stronger capabilities for tackling future challenges. This allows them to override the trade-offs and limitations that evolution has built into the organism's repair processes in order to conserve potentially scarce resources. Such acute, "hormetic" stressors strengthen the organism in part via the "order from noise" mechanism that destroys dysfunctional structures by subjecting them to strong, random variations. They include heat and cold, physical exertion, exposure, stretching, vibration, fasting, food toxins, micro-organisms, environmental enrichment and psychological challenges. The proposed buffering-challenging strategy may be able to extend life indefinitely, by forcing a periodic rebuilding and extension of capabilities, while using the Internet as an endless source of new knowledge about how to deal with disturbances.

Regional Responses to Constrained Water Availability

NASA Astrophysics Data System (ADS)

Cui, Y.; Calvin, K. V.; Hejazi, M. I.; Clarke, L.; Kim, S. H.; Patel, P.

2017-12-01

There have been many concerns about water as a constraint to agricultural production, electricity generation, and many other human activities in the coming decades. Nevertheless, how different countries/economies would respond to such constraints has not been explored. Here, we examine the responding mechanism of binding water availability constraints at the water basin level and across a wide range of socioeconomic, climate and energy technology scenarios. Specifically, we look at the change in water withdrawals between energy, land-use and other sectors within an integrated framework, by using the Global Change Assessment Model (GCAM) that also endogenizes water use and allocation decisions based on costs. We find that, when water is taken into account as part of the production decision-making, countries/basins in general fall into three different categories, depending on the change of water withdrawals and water re-allocation between sectors. First, water is not a constraining factor for most of the basins. Second, advancements in water-saving technologies of the electricity generation cooling systems are sufficient of reducing water withdrawals to meet binding water availability constraints, such as in China and the EU-15. Third, water-saving in the electricity sector alone is not sufficient and thus cannot make up the lowered water availability from the binding case; for example, many basins in Pakistan, Middle East and India have to largely reduce irrigated water withdrawals by either switching to rain-fed agriculture or reducing production. The dominant responding strategy for individual countries/basins is quite robust across the range of alternate scenarios that we test. The relative size of water withdrawals between energy and agriculture sectors is one of the most important factors that affect the dominant mechanism.

Building test data from real outbreaks for evaluating detection algorithms.

PubMed

Texier, Gaetan; Jackson, Michael L; Siwe, Leonel; Meynard, Jean-Baptiste; Deparis, Xavier; Chaudet, Herve

2017-01-01

Benchmarking surveillance systems requires realistic simulations of disease outbreaks. However, obtaining these data in sufficient quantity, with a realistic shape and covering a sufficient range of agents, size and duration, is known to be very difficult. The dataset of outbreak signals generated should reflect the likely distribution of authentic situations faced by the surveillance system, including very unlikely outbreak signals. We propose and evaluate a new approach based on the use of historical outbreak data to simulate tailored outbreak signals. The method relies on a homothetic transformation of the historical distribution followed by resampling processes (Binomial, Inverse Transform Sampling Method-ITSM, Metropolis-Hasting Random Walk, Metropolis-Hasting Independent, Gibbs Sampler, Hybrid Gibbs Sampler). We carried out an analysis to identify the most important input parameters for simulation quality and to evaluate performance for each of the resampling algorithms. Our analysis confirms the influence of the type of algorithm used and simulation parameters (i.e. days, number of cases, outbreak shape, overall scale factor) on the results. We show that, regardless of the outbreaks, algorithms and metrics chosen for the evaluation, simulation quality decreased with the increase in the number of days simulated and increased with the number of cases simulated. Simulating outbreaks with fewer cases than days of duration (i.e. overall scale factor less than 1) resulted in an important loss of information during the simulation. We found that Gibbs sampling with a shrinkage procedure provides a good balance between accuracy and data dependency. If dependency is of little importance, binomial and ITSM methods are accurate. Given the constraint of keeping the simulation within a range of plausible epidemiological curves faced by the surveillance system, our study confirms that our approach can be used to generate a large spectrum of outbreak signals.

Building test data from real outbreaks for evaluating detection algorithms

PubMed Central

Texier, Gaetan; Jackson, Michael L.; Siwe, Leonel; Meynard, Jean-Baptiste; Deparis, Xavier; Chaudet, Herve

2017-01-01

Benchmarking surveillance systems requires realistic simulations of disease outbreaks. However, obtaining these data in sufficient quantity, with a realistic shape and covering a sufficient range of agents, size and duration, is known to be very difficult. The dataset of outbreak signals generated should reflect the likely distribution of authentic situations faced by the surveillance system, including very unlikely outbreak signals. We propose and evaluate a new approach based on the use of historical outbreak data to simulate tailored outbreak signals. The method relies on a homothetic transformation of the historical distribution followed by resampling processes (Binomial, Inverse Transform Sampling Method—ITSM, Metropolis-Hasting Random Walk, Metropolis-Hasting Independent, Gibbs Sampler, Hybrid Gibbs Sampler). We carried out an analysis to identify the most important input parameters for simulation quality and to evaluate performance for each of the resampling algorithms. Our analysis confirms the influence of the type of algorithm used and simulation parameters (i.e. days, number of cases, outbreak shape, overall scale factor) on the results. We show that, regardless of the outbreaks, algorithms and metrics chosen for the evaluation, simulation quality decreased with the increase in the number of days simulated and increased with the number of cases simulated. Simulating outbreaks with fewer cases than days of duration (i.e. overall scale factor less than 1) resulted in an important loss of information during the simulation. We found that Gibbs sampling with a shrinkage procedure provides a good balance between accuracy and data dependency. If dependency is of little importance, binomial and ITSM methods are accurate. Given the constraint of keeping the simulation within a range of plausible epidemiological curves faced by the surveillance system, our study confirms that our approach can be used to generate a large spectrum of outbreak signals. PMID:28863159

Extended-Range High-Resolution Dynamical Downscaling over a Continental-Scale Domain

NASA Astrophysics Data System (ADS)

Husain, S. Z.; Separovic, L.; Yu, W.; Fernig, D.

2014-12-01

High-resolution mesoscale simulations, when applied for downscaling meteorological fields over large spatial domains and for extended time periods, can provide valuable information for many practical application scenarios including the weather-dependent renewable energy industry. In the present study, a strategy has been proposed to dynamically downscale coarse-resolution meteorological fields from Environment Canada's regional analyses for a period of multiple years over the entire Canadian territory. The study demonstrates that a continuous mesoscale simulation over the entire domain is the most suitable approach in this regard. Large-scale deviations in the different meteorological fields pose the biggest challenge for extended-range simulations over continental scale domains, and the enforcement of the lateral boundary conditions is not sufficient to restrict such deviations. A scheme has therefore been developed to spectrally nudge the simulated high-resolution meteorological fields at the different model vertical levels towards those embedded in the coarse-resolution driving fields derived from the regional analyses. A series of experiments were carried out to determine the optimal nudging strategy including the appropriate nudging length scales, nudging vertical profile and temporal relaxation. A forcing strategy based on grid nudging of the different surface fields, including surface temperature, soil-moisture, and snow conditions, towards their expected values obtained from a high-resolution offline surface scheme was also devised to limit any considerable deviation in the evolving surface fields due to extended-range temporal integrations. The study shows that ensuring large-scale atmospheric similarities helps to deliver near-surface statistical scores for temperature, dew point temperature and horizontal wind speed that are better or comparable to the operational regional forecasts issued by Environment Canada. Furthermore, the meteorological fields resulting from the proposed downscaling strategy have significantly improved spatiotemporal variance compared to those from the operational forecasts, and any time series generated from the downscaled fields do not suffer from discontinuities due to switching between the consecutive forecasts.

Psychometric properties of the foot and ankle outcome score in a community-based study of adults with and without osteoarthritis.

PubMed

Golightly, Yvonne M; Devellis, Robert F; Nelson, Amanda E; Hannan, Marian T; Lohmander, L Stefan; Renner, Jordan B; Jordan, Joanne M

2014-03-01

Foot and ankle problems are common in adults, and large observational studies are needed to advance our understanding of the etiology and impact of these conditions. Valid and reliable measures of foot and ankle symptoms and physical function are necessary for this research. This study examined psychometric properties of the Foot and Ankle Outcome Score (FAOS) subscales (pain, other symptoms, activities of daily living [ADL], sport and recreational function [sport/recreation], and foot- and ankle-related quality of life [QOL]) in a large, community-based sample of African American and white men and women ages ≥50 years. Johnston County Osteoarthritis Project participants (n = 1,670) completed the 42-item FAOS (mean age 69 years, 68% women, 31% African American, mean body mass index [BMI] 31.5 kg/m(2) ). Internal consistency, test-retest reliability, convergent validity, and structural validity of each subscale were examined for the sample and for subgroups according to race, sex, age, BMI, presence of knee or hip osteoarthritis, and presence of knee, hip, or low back symptoms. For the sample and each subgroup, Cronbach's alpha coefficients ranged from 0.95-0.97 (pain), 0.97-0.98 (ADL), 0.94-0.96 (sport/recreation), 0.89-0.92 (QOL), and 0.72-0.82 (symptoms). Correlation coefficients ranged from 0.24-0.52 for pain and symptoms subscales with foot and ankle symptoms and from 0.30-0.55 for ADL and sport/recreation subscales with the Western Ontario and McMaster Universities Osteoarthritis Index function subscale. Intraclass correlation coefficients for test-retest reliability ranged from 0.63-0.81. Items loaded on a single factor for each subscale except symptoms (2 factors). The FAOS exhibited sufficient reliability and validity in this large cohort study. Copyright © 2014 by the American College of Rheumatology.

Eating and health behaviors in vegans compared to omnivores: Dispelling common myths.

PubMed

Heiss, Sydney; Coffino, Jaime A; Hormes, Julia M

2017-11-01

Studies comparing eating behaviors in individuals avoiding meat and other animal products to omnivores have produced largely inconclusive findings, in part due to a failure to obtain sufficiently large samples of vegan participants to make meaningful comparisons. This study examined eating and health behaviors in a large community sample of dietary vegans ("vegans"), compared to omnivores. Participants (n = 578, 80.4% female) completed an online questionnaire assessing a range of eating- and other health-related attitudes and behaviors. Vegans (62.0%, n = 358) and omnivores (38.1%, n = 220) were comparable in terms of demographics. Vegans scored significantly lower than omnivores the Eating Disorder Examination - Questionnaire (multivariate p < 0.001), a measure of pathological eating behavior. They also were more likely to consider themselves "healthy" (p < 0.001) and to prepare food at home (p < 0.001). Vegans more frequently consumed fruits, vegetables, nuts, beans and grains (all p < 0.001), and less frequently consumed caffeinated soft drinks (p < 0.001). There were no significant differences between vegans and omnivores on measures of eating styles, body mass index, smoking or exercise behaviors, or problems related to alcohol consumption. Effect sizes for comparisons on eating-related measures were generally small, with η p 2 ranging from <0.01 to 0.05; the size of effects for comparisons on measures of other health behaviors ranged from small to medium (Φ = 0.09 to 0.33 and η p 2 < 0.01 to 0.42). Taken together, findings suggest that ultimately, vegans do not differ much from omnivores in their eating attitudes and behaviors, and when they do, differences indicate slightly healthier attitudes and behaviors towards food. Similarly, vegans closely resembled omnivores in non-eating related health behaviors. Copyright © 2017 Elsevier Ltd. All rights reserved.

Lightning Mapping Observations During DC3 in Northern Colorado

NASA Astrophysics Data System (ADS)

Krehbiel, P. R.; Rison, W.; Thomas, R. J.

2012-12-01

The Deep Convective Clouds and Chemistry Experiment (DC3) was conducted in three regions covered by Lightning Mapping Arrays (LMAs): Oklahoma and west Texas, northern Alabama, and northern Colorado. In this and a companion presentation, we discuss results obtained from the newly-deployed North Colorado LMA. The CO LMA revealed a surprising variety of lightning-inferred electrical structures, ranging from classic tripolar, normal polarity storms to several variations of anomalously electrified systems. Storms were often characterized by a pronounced lack or deficit of cloud-to-ground discharges (negative or positive), both in relative and absolute terms compared to the large amount of intracloud activity revealed by the LMA. Anomalous electrification was observed in small, localized storms as well as in large, deeply convective and severe storms. Another surprising observation was the frequent occurrence of embedded convection in the downwind anvil/outflow region of large storm systems. Observations of discharges in low flash rate situations over or near the network are sufficiently detailed to enable branching algorithms to estimate total channel lengths for modeling NOx production. However, this will not be possible in large or distant storm systems where the lightning was essentially continuous and structurally complex, or spatially noisy. Rather, a simple empirical metric for characterizing the lightning activity can be developed based on the number of located VHF radiation sources, weighted for example by the peak source power, source altitude, and temporal duration.

Phase stability in the two-dimensional anisotropic boson Hubbard Hamiltonian

DOE PAGES

Ying, T.; Batrouni, G. G.; Rousseau, V. G.; ...

2013-05-15

The two dimensional square lattice hard-core boson Hubbard model with near neighbor interactions has a ‘checkerboard’ charge density wave insulating phase at half-filling and sufficiently large intersite repulsion. When doped, rather than forming a supersolid phase in which long range charge density wave correlations coexist with a condensation of superfluid defects, the system instead phase separates. However, it is known that there are other lattice geometries and interaction patterns for which such coexistence takes place. In this paper we explore the possibility that anisotropic hopping or anisotropic near neighbor repulsion might similarly stabilize the square lattice supersolid. Lastly, by consideringmore » the charge density wave structure factor and superfluid density for different ratios of interaction strength and hybridization in the ˆx and ˆy directions, we conclude that phase separation still occurs.« less

Distribution of guidance models for cardiac resynchronization therapy in the setting of multi-center clinical trials

NASA Astrophysics Data System (ADS)

Rajchl, Martin; Abhari, Kamyar; Stirrat, John; Ukwatta, Eranga; Cantor, Diego; Li, Feng P.; Peters, Terry M.; White, James A.

2014-03-01

Multi-center trials provide the unique ability to investigate novel techniques across a range of geographical sites with sufficient statistical power, the inclusion of multiple operators determining feasibility under a wider array of clinical environments and work-flows. For this purpose, we introduce a new means of distributing pre-procedural cardiac models for image-guided interventions across a large scale multi-center trial. In this method, a single core facility is responsible for image processing, employing a novel web-based interface for model visualization and distribution. The requirements for such an interface, being WebGL-based, are minimal and well within the realms of accessibility for participating centers. We then demonstrate the accuracy of our approach using a single-center pacemaker lead implantation trial with generic planning models.

Segregation and microstructure evolution in chill cast and directionally solidified Ni-Mn-Sn metamagnetic shape memory alloys

NASA Astrophysics Data System (ADS)

Czaja, P.; Wierzbicka-Miernik, A.; Rogal, Ł.

2018-06-01

A multiphase solidification behaviour is confirmed for a range of Ni-rich and Ni-deficient Ni-Mn-Sn induction cast and directionally solidified (Bridgman) alloys. The composition variation is primarily linked to the changing Mn/Sn ratio, whereas the content of Ni remains largely stable. The partitioning coefficients for the Ni50Mn37Sn13 and Ni46Mn41.5Sn12.5 Bridgman alloys were obtained according to the Scheil equation based on the composition distribution along the longitudinal cross section of the ingots. Homogenization heat treatment performed for 72 h at 1220 K turned out sufficient for ensuring chemical uniformity on the macro- and microscale. It is owed to a limited segregation length scale due to slow cooling rates adopted for the directional solidification process.

Flight motor modulation with speed in the hawkmoth Manduca sexta.

PubMed

Hedrick, Tyson L; Martínez-Blat, Jorge; Goodman, Mariah J

2017-01-01

The theoretical underpinnings for flight, including animal flight with flapping wings, predict a curvilinear U-shaped or J-shaped relationship between flight speed and the power required to maintain that speed. Experimental data have confirmed this relationship for a variety of bird and bat species but not insects, possibly due to differences in aerodynamics and physiology or experimental difficulties. Here we quantify modulation of the main flight motor muscles (the dorsolongitudinal and dorsoventral) via electromyography in hawkmoths (Manduca sexta) flying freely over a range of speeds in a wind tunnel and show that these insects exhibit a U-shaped speed-power relationship, with a minimum power speed of 2ms -1 , indicating that at least large flying insects achieve sufficiently high flight speeds that drag and power become limiting factors. Copyright © 2016 Elsevier Ltd. All rights reserved.

Radiative human body cooling by nanoporous polyethylene textile.

PubMed

Hsu, Po-Chun; Song, Alex Y; Catrysse, Peter B; Liu, Chong; Peng, Yucan; Xie, Jin; Fan, Shanhui; Cui, Yi

2016-09-02

Thermal management through personal heating and cooling is a strategy by which to expand indoor temperature setpoint range for large energy saving. We show that nanoporous polyethylene (nanoPE) is transparent to mid-infrared human body radiation but opaque to visible light because of the pore size distribution (50 to 1000 nanometers). We processed the material to develop a textile that promotes effective radiative cooling while still having sufficient air permeability, water-wicking rate, and mechanical strength for wearability. We developed a device to simulate skin temperature that shows temperatures 2.7° and 2.0°C lower when covered with nanoPE cloth and with processed nanoPE cloth, respectively, than when covered with cotton. Our processed nanoPE is an effective and scalable textile for personal thermal management. Copyright © 2016, American Association for the Advancement of Science.

A high-throughput label-free nanoparticle analyser.

PubMed

Fraikin, Jean-Luc; Teesalu, Tambet; McKenney, Christopher M; Ruoslahti, Erkki; Cleland, Andrew N

2011-05-01

Synthetic nanoparticles and genetically modified viruses are used in a range of applications, but high-throughput analytical tools for the physical characterization of these objects are needed. Here we present a microfluidic analyser that detects individual nanoparticles and characterizes complex, unlabelled nanoparticle suspensions. We demonstrate the detection, concentration analysis and sizing of individual synthetic nanoparticles in a multicomponent mixture with sufficient throughput to analyse 500,000 particles per second. We also report the rapid size and titre analysis of unlabelled bacteriophage T7 in both salt solution and mouse blood plasma, using just ~1 × 10⁻⁶ l of analyte. Unexpectedly, in the native blood plasma we discover a large background of naturally occurring nanoparticles with a power-law size distribution. The high-throughput detection capability, scalable fabrication and simple electronics of this instrument make it well suited for diverse applications.

Comparison of Cirrus Cloud Models: A Project of the GEWEX Cloud System Study (GCSS) Working Group on Cirrus Cloud Systems

NASA Technical Reports Server (NTRS)

Starr, David O'C.; Benedetti, Angela; Boehm, Matt; Brown, Philip R. A.; Gierens, Klaus M.; Girard, Eric; Giraud, Vincent; Jakob, Christian; Jensen, Eric

2000-01-01

The GEWEX Cloud System Study (GCSS, GEWEX is the Global Energy and Water Cycle Experiment) is a community activity aiming to promote development of improved cloud parameterizations for application in the large-scale general circulation models (GCMs) used for climate research and for numerical weather prediction. The GCSS strategy is founded upon the use of cloud-system models (CSMs). These are "process" models with sufficient spatial and temporal resolution to represent individual cloud elements, but spanning a wide range of space and time scales to enable statistical analysis of simulated cloud systems. GCSS also employs single-column versions of the parametric cloud models (SCMs) used in GCMs. GCSS has working groups on boundary-layer clouds, cirrus clouds, extratropical layer cloud systems, precipitating deep convective cloud systems, and polar clouds.

Recent developments in plastic scintillators with pulse shape discrimination

NASA Astrophysics Data System (ADS)

Zaitseva, N. P.; Glenn, A. M.; Mabe, A. N.; Carman, M. L.; Hurlbut, C. R.; Inman, J. W.; Payne, S. A.

2018-05-01

The paper reports results of studies conducted to improve scintillation performance of plastic scintillators capable of neutron/gamma pulse-shape discrimination (PSD). Compositional modifications made with the polymer matrix improved physical stability, allowing for increased loads of the primary dye that, in combination with selected secondary dyes, provided enhanced PSD especially important for the lower energy ranges. Additional measurements were made with a newly-introduced PSD plastic EJ-276, that replaces the first commercially produced EJ-299. Comparative studies conducted with the new materials and EJ-309 liquids at large scale (up to 10 cm) show that current plastics may provide scintillation and PSD performance sufficient for the replacement of liquid scintillators. Comparison to stilbene single crystals compliments the information about the status of the solid-state materials recently developed for fast neutron detection applications.

Reporting Recommended Patch Density from Vehicle Panel Vibration Convergence Studies using both DAF and TBL Fits of the Spatial Correlation Function

NASA Technical Reports Server (NTRS)

Smith, Andrew M.; Davis, Robert Ben; LaVerde, Bruce T.; Jones, Douglas C.; Band, Jonathon L.

2012-01-01

Using the patch method to represent the continuous spatial correlation function of a phased pressure field over a structural surface is an approximation. The approximation approaches the continuous function as patches become smaller. Plotting comparisons of the approximation vs the continuous function may provide insight revealing: (1) For what patch size/density should the approximation be very good? (2) What the approximation looks like when it begins to break down? (3) What the approximation looks like when the patch size is grossly too large. Following these observations with a convergence study using one FEM may allow us to see the importance of patch density. We may develop insights that help us to predict sufficient patch density to provide adequate convergence for the intended purpose frequency range of interest

Inorganic Nanocrystals Functionalized Mesoporous Silica Nanoparticles: Fabrication and Enhanced Bio-applications

NASA Astrophysics Data System (ADS)

Zhao, Tiancong; Nguyen, Nam-Trung; Xie, Yang; Sun, Xiaofei; Li, Qin; Li, Xiaomin

2017-12-01

Mesoporous SiO2 nanoparticles (MSNs) are one of the most promising materials for bio-related applications due to advantages such as good biocompatibility, tunable mesopores and large pore volume. However, unlike the inorganic nanocrystals with abundant physical properties, MSNs alone lack functional features. Thus, they are not sufficiently suitable for bio-applications that require special functions. Consequently, MSNs are often functionalized by incorporating inorganic nanocrystals, which provide a wide range of intriguing properties. This review focuses on inorganic nanocrystals functionalized MSNs, both their fabrication and bio-applications. Some of the most utilized methods for coating mesoporous silica (mSiO2) on nanoparticles were summarized. Magnetic, fluorescence and photothermal inorganic nanocrystals functionalized MSNs were taken as examples to demonstrate the bio-applications. Furthermore, asymmetry of MSNs and their effects on functions were also highlighted.

Close Range Uav Accurate Recording and Modeling of St-Pierre Neo-Romanesque Church in Strasbourg (france)

NASA Astrophysics Data System (ADS)

Murtiyoso, A.; Grussenmeyer, P.; Freville, T.

2017-02-01

Close-range photogrammetry is an image-based technique which has often been used for the 3D documentation of heritage objects. Recently, advances in the field of image processing and UAVs (Unmanned Aerial Vehicles) have resulted in a renewed interest in this technique. However, commercially ready-to-use UAVs are often equipped with smaller sensors in order to minimize payload and the quality of the documentation is still an issue. In this research, two commercial UAVs (the Sensefly Albris and DJI Phantom 3 Professional) were setup to record the 19th century St-Pierre-le-Jeune church in Strasbourg, France. Several software solutions (commercial and open source) were used to compare both UAVs' images in terms of calibration, accuracy of external orientation, as well as dense matching. Results show some instability in regards to the calibration of Phantom 3, while the Albris had issues regarding its aerotriangulation results. Despite these shortcomings, both UAVs succeeded in producing dense point clouds of up to a few centimeters in accuracy, which is largely sufficient for the purposes of a city 3D GIS (Geographical Information System). The acquisition of close range images using UAVs also provides greater LoD flexibility in processing. These advantages over other methods such as the TLS (Terrestrial Laser Scanning) or terrestrial close range photogrammetry can be exploited in order for these techniques to complement each other.

A multilocus population genetic survey of the greater sage-grouse across their range.

PubMed

Oyler-McCance, S J; Taylor, S E; Quinn, T W

2005-04-01

The distribution and abundance of the greater sage-grouse (Centrocercus urophasianus) have declined dramatically, and as a result the species has become the focus of conservation efforts. We conducted a range-wide genetic survey of the species which included 46 populations and over 1000 individuals using both mitochondrial sequence data and data from seven nuclear microsatellites. Nested clade and structure analyses revealed that, in general, the greater sage-grouse populations follow an isolation-by-distance model of restricted gene flow. This suggests that movements of the greater sage-grouse are typically among neighbouring populations and not across the species, range. This may have important implications if management is considering translocations as they should involve neighbouring rather than distant populations to preserve any effects of local adaptation. We identified two populations in Washington with low levels of genetic variation that reflect severe habitat loss and dramatic population decline. Managers of these populations may consider augmentation from geographically close populations. One population (Lyon/Mono) on the southwestern edge of the species' range appears to have been isolated from all other greater sage-grouse populations. This population is sufficiently genetically distinct that it warrants protection and management as a separate unit. The genetic data presented here, in conjunction with large-scale demographic and habitat data, will provide an integrated approach to conservation efforts for the greater sage-grouse.

Teaching Students about Plagiarism: An Internet Solution to an Internet Problem

ERIC Educational Resources Information Center

Snow, Eleanour

2006-01-01

The Internet has changed the ways that students think, learn, and write. Students have large amounts of information, largely anonymous and without clear copyright information, literally at their fingertips. Without sufficient guidance, the inappropriate use of this information seems inevitable. Plagiarism among college students is rising, due to…

A COMPARISON OF SIX BENTHIC MACROINVERTEBRATE SAMPLING METHODS IN FOUR LARGE RIVERS

EPA Science Inventory

In 1999, a study was conducted to compare six macroinvertebrate sampling methods in four large (boatable) rivers that drain into the Ohio River. Two methods each were adapted from existing methods used by the USEPA, USGS and Ohio EPA. Drift nets were unable to collect a suffici...

Status of lake trout rehabilitation in the Northern Refuge of Lake Michigan

USGS Publications Warehouse

Madenjian, Charles P.; DeSorcie, Timothy J.

1999-01-01

The Northern Refuge in Lake Michigan was established in 1985 as part of a rehabilitation program to stock yearling lake trout Salvelinus namaycush in areas with the best potential for success. Stocking of hatchery-reared lake trout within the refuge began in 1986 at three reefs: Boulder Reef, Gull Island Reef, and Richards Reef. On each reef from 1991 to 1997 we conducted gill-net surveys during the fall spawning season to evaluate performance of adult lake trout, and we conducted beam trawl surveys for naturally reproduced age-0 lake trout in the spring. Criteria to evaluate performance included spawner density, growth, maturity, and mortality. We found no evidence of natural reproduction by lake trout from our surveys. Nevertheless, density of spawning lake trout on Boulder Reef (69 fish/305 m of gill net/night) and Gull Island Reef (34 fish/305 m of gill net/night) appeared to be sufficiently high to initiate a self-sustaining population. Growth and maturity rates of lake trout in the Northern Refuge were similar to those for lake trout stocked in the nearshore region of Lake Michigan. In the Northern Refuge, growth rate for the Marquette strain of lake trout was slightly higher than for the Lewis Lake strain. Annual mortality estimates from catch curve analyses ranged from 0.46 to 0.41, and therefore, these estimates approached a level that was considered to be sufficiently low to allow for a self-sustaining population. Thus, it appeared that the lack of evidence for natural reproduction by lake trout in the Northern Refuge should not be attributed to inability of the population to attain a sufficiently large stock of spawners.

Information content analysis: the potential for methane isotopologue retrieval from GOSAT-2

NASA Astrophysics Data System (ADS)

Malina, Edward; Yoshida, Yukio; Matsunaga, Tsuneo; Muller, Jan-Peter

2018-02-01

Atmospheric methane is comprised of multiple isotopic molecules, with the most abundant being 12CH4 and 13CH4, making up 98 and 1.1 % of atmospheric methane respectively. It has been shown that is it possible to distinguish between sources of methane (biogenic methane, e.g. marshland, or abiogenic methane, e.g. fracking) via a ratio of these main methane isotopologues, otherwise known as the δ13C value. δ13C values typically range between -10 and -80 ‰, with abiogenic sources closer to zero and biogenic sources showing more negative values. Initially, we suggest that a δ13C difference of 10 ‰ is sufficient, in order to differentiate between methane source types, based on this we derive that a precision of 0.2 ppbv on 13CH4 retrievals may achieve the target δ13C variance. Using an application of the well-established information content analysis (ICA) technique for assumed clear-sky conditions, this paper shows that using a combination of the shortwave infrared (SWIR) bands on the planned Greenhouse gases Observing SATellite (GOSAT-2) mission, 13CH4 can be measured with sufficient information content to a precision of between 0.7 and 1.2 ppbv from a single sounding (assuming a total column average value of 19.14 ppbv), which can then be reduced to the target precision through spatial and temporal averaging techniques. We therefore suggest that GOSAT-2 can be used to differentiate between methane source types. We find that large unconstrained covariance matrices are required in order to achieve sufficient information content, while the solar zenith angle has limited impact on the information content.

Quantifying the utilization of medical devices necessary to detect postmarket safety differences: A case study of implantable cardioverter defibrillators.

PubMed

Bates, Jonathan; Parzynski, Craig S; Dhruva, Sanket S; Coppi, Andreas; Kuntz, Richard; Li, Shu-Xia; Marinac-Dabic, Danica; Masoudi, Frederick A; Shaw, Richard E; Warner, Frederick; Krumholz, Harlan M; Ross, Joseph S

2018-06-12

To estimate medical device utilization needed to detect safety differences among implantable cardioverter defibrillators (ICDs) generator models and compare these estimates to utilization in practice. We conducted repeated sample size estimates to calculate the medical device utilization needed, systematically varying device-specific safety event rate ratios and significance levels while maintaining 80% power, testing 3 average adverse event rates (3.9, 6.1, and 12.6 events per 100 person-years) estimated from the American College of Cardiology's 2006 to 2010 National Cardiovascular Data Registry of ICDs. We then compared with actual medical device utilization. At significance level 0.05 and 80% power, 34% or fewer ICD models accrued sufficient utilization in practice to detect safety differences for rate ratios <1.15 and an average event rate of 12.6 events per 100 person-years. For average event rates of 3.9 and 12.6 events per 100 person-years, 30% and 50% of ICD models, respectively, accrued sufficient utilization for a rate ratio of 1.25, whereas 52% and 67% for a rate ratio of 1.50. Because actual ICD utilization was not uniformly distributed across ICD models, the proportion of individuals receiving any ICD that accrued sufficient utilization in practice was 0% to 21%, 32% to 70%, and 67% to 84% for rate ratios of 1.05, 1.15, and 1.25, respectively, for the range of 3 average adverse event rates. Small safety differences among ICD generator models are unlikely to be detected through routine surveillance given current ICD utilization in practice, but large safety differences can be detected for most patients at anticipated average adverse event rates. Copyright © 2018 John Wiley & Sons, Ltd.

Sufficient Forecasting Using Factor Models

PubMed Central

Fan, Jianqing; Xue, Lingzhou; Yao, Jiawei

2017-01-01

We consider forecasting a single time series when there is a large number of predictors and a possible nonlinear effect. The dimensionality was first reduced via a high-dimensional (approximate) factor model implemented by the principal component analysis. Using the extracted factors, we develop a novel forecasting method called the sufficient forecasting, which provides a set of sufficient predictive indices, inferred from high-dimensional predictors, to deliver additional predictive power. The projected principal component analysis will be employed to enhance the accuracy of inferred factors when a semi-parametric (approximate) factor model is assumed. Our method is also applicable to cross-sectional sufficient regression using extracted factors. The connection between the sufficient forecasting and the deep learning architecture is explicitly stated. The sufficient forecasting correctly estimates projection indices of the underlying factors even in the presence of a nonparametric forecasting function. The proposed method extends the sufficient dimension reduction to high-dimensional regimes by condensing the cross-sectional information through factor models. We derive asymptotic properties for the estimate of the central subspace spanned by these projection directions as well as the estimates of the sufficient predictive indices. We further show that the natural method of running multiple regression of target on estimated factors yields a linear estimate that actually falls into this central subspace. Our method and theory allow the number of predictors to be larger than the number of observations. We finally demonstrate that the sufficient forecasting improves upon the linear forecasting in both simulation studies and an empirical study of forecasting macroeconomic variables. PMID:29731537

Cooling system for continuous metal casting machines

DOEpatents

Draper, Robert; Sumpman, Wayne C.; Baker, Robert J.; Williams, Robert S.

1988-01-01

A continuous metal caster cooling system is provided in which water is supplied in jets from a large number of small nozzles 19 against the inner surface of rim 13 at a temperature and with sufficient pressure that the velocity of the jets is sufficiently high that the mode of heat transfer is substantially by forced convection, the liquid being returned from the cooling chambers 30 through return pipes 25 distributed interstitially among the nozzles.

Cooling system for continuous metal casting machines

DOEpatents

Draper, R.; Sumpman, W.C.; Baker, R.J.; Williams, R.S.

1988-06-07

A continuous metal caster cooling system is provided in which water is supplied in jets from a large number of small nozzles against the inner surface of rim at a temperature and with sufficient pressure that the velocity of the jets is sufficiently high that the mode of heat transfer is substantially by forced convection, the liquid being returned from the cooling chambers through return pipes distributed interstitially among the nozzles. 9 figs.

Short- and long-range energy strategies for Japan and the world after the Fukushima nuclear accident

NASA Astrophysics Data System (ADS)

Muraoka, K.; Wagner, F.; Yamagata, Y.; Donné, A. J. H.

2016-01-01

The accident at the Fukushima Dai-ichi nuclear power station in 2011 has caused profound effects on energy policies in Japan and worldwide. This is particularly because it occurred at the time of the growing awareness of global warming forcing measures towards decarbonised energy production, namely the use of fossil fuels has to be drastically reduced from the present level of more than 80% by 2050. A dilemma has now emerged because nuclear power, a CO2-free technology with proven large-scale energy production capability, lost confidence in many societies, especially in Japan and Germany. As a consequence, there is a world-wide effort now to expand renewable energies (REs), specifically photo-voltaic (PV) and wind power. However, the authors conjecture that PV and wind power can provide only up to a 40% share of the electricity production as long as sufficient storage is not available. Beyond this level, the technological (high grid power) and economic problems (large surplus production) grow. This is the result of the analysis of the growing use of REs in the electricity systems for Germany and Japan. The key element to overcome this situation is to develop suitable energy storage technologies. This is particularly necessary when electricity will become the main energy source because also transportation, process heat and heating, will be supplied by it. Facing the difficulty in replacing all fossil fuels in all countries with different technology standards, a rapid development of carbon capture and storage (CCS) might also be necessary. Therefore, for the short-range strategy up to 2050, all meaningful options have to be developed. For the long-range strategy beyond 2050, new energy sources (such as thermonuclear fusion, solar fuels and nuclear power—if inherently safe concepts will gain credibility of societies again), and large-scale energy storage systems based on novel concepts (such as large-capacity batteries and hydrogen) is required. It is acknowledged that the prediction of the future is difficult; therefore, the only insurance in this situation is by intensified research into all viable options.

Significant wave heights from Sentinel-1 SAR: Validation and applications

NASA Astrophysics Data System (ADS)

Stopa, J. E.; Mouche, A.

2017-03-01

Two empirical algorithms are developed for wave mode images measured from the synthetic aperture radar aboard Sentinel-1 A. The first method, called CWAVE_S1A, is an extension of previous efforts developed for ERS2 and the second method, called Fnn, uses the azimuth cutoff among other parameters to estimate significant wave heights (Hs) and average wave periods without using a modulation transfer function. Neural networks are trained using colocated data generated from WAVEWATCH III and independently verified with data from altimeters and in situ buoys. We use neural networks to relate the nonlinear relationships between the input SAR image parameters and output geophysical wave parameters. CWAVE_S1A performs well and has reduced precision compared to Fnn with Hs root mean square errors within 0.5 and 0.6 m, respectively. The developed neural networks extend the SAR's ability to retrieve useful wave information under a large range of environmental conditions including extratropical and tropical cyclones in which Hs estimation is traditionally challenging.