Overview of the Health and Retirement Study and Introduction to the Special Issue.

PubMed

Fisher, Gwenith G; Ryan, Lindsay H

2018-01-01

Twenty five years ago, the largest academic behavioral and social science project ever undertaken in the U.S. began: the Health and Retirement Study (HRS). The HRS is an invaluable publicly available dataset for investigating work, aging, and retirement and informing public policy on these issues. This biennial longitudinal study began in 1992 and has studied more than 43,000 individuals and produced almost 4000 journal articles, dissertations, books, book chapters, and reports to date. The purpose of this special issue of Work, Aging and Retirement is to describe the HRS and highlight relevant research that utilizes this rich and complex dataset. First, we briefly describe the background that led to the development of the HRS. Then we summarize key aspects of the study, including its development, sampling, and methodology. Our review of the content of the survey focuses on the aspects of the study most relevant to research on worker aging and retirement. Next, we identify key strengths and important limitations of the study and provide advice to current and future HRS data users. Finally, we summarize the articles in this Special Issue (all of which use data from the HRS) and how they advance our knowledge and understanding of worker aging and retirement.

Key Federal Regulations Affecting the Handicapped 1975-1976.

ERIC Educational Resources Information Center

National Association of Coordinators of State Programs for the Mentally Retarded, Arlington, VA.

Summarized are major federal regulations affecting the handicapped issued during 1976. Regulations are organized according to the following categories: health (such as long term care and home health services, health planning, and facilities construction); education (such as handicapped education grants to the states, early childhood education, and…

Role of CCTs in the evolving domestic electricity market

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grahame, T.J.

1997-12-31

The paper summarizes the key points and issues in the role of clean coal technologies in the domestic marketplace. Then suggested solutions to bringing precommercial CCTs to the market are presented. Finally, the outlook for possible actions by government and the private sector are briefly discussed.

Performance-Based Funding Brief

ERIC Educational Resources Information Center

Washington Higher Education Coordinating Board, 2011

2011-01-01

A number of states have made progress in implementing performance-based funding (PFB) and accountability. This policy brief summarizes main features of performance-based funding systems in three states: Tennessee, Ohio, and Indiana. The brief also identifies key issues that states considering performance-based funding must address, as well as…

Intergenerational Programmes: Public Policy and Research Implications--An International Perspective.

ERIC Educational Resources Information Center

Hatton-Yeo, Alan, Ed.; Ohsako, Toshio, Ed.

This document consists of 12 papers that, together, summarize the key issues underpinning future research and policy development related to intergenerational programs (IPs). "Introduction" (Alan Hatton-Yeo) discusses the project out of which the papers developed. "A General Assessment of IP Initiatives in the Countries…

Critical Measurement Issues in Translational Research

ERIC Educational Resources Information Center

Glasgow, Russell E.

2009-01-01

This article summarizes critical evaluation needs, challenges, and lessons learned in translational research. Evaluation can play a key role in enhancing successful application of research-based programs and tools as well as informing program refinement and future research. Discussion centers on what is unique about evaluating programs and…

The First World Congress on the Management of Electronic Commerce: Review and Commentary.

ERIC Educational Resources Information Center

Bontis, Nick; De Castro, Akemi

2000-01-01

Summarizes some key findings of academic papers presented at the First World Congress on the Management of Electronic Commerce (January, 2000, Hamilton, Ontario, Canada). Outlines two meta-management issues that surfaced: taking a strategic approach to Internet ventures and considering infrastructure design during implementation. Highlights…

Sociocultural Perspectives on Transition to School from Pacific Islands Early Childhood Centres.

ERIC Educational Resources Information Center

Podmore, Valerie N.; Sauvao, Le'Autuli'ilagi M.; Mapa, Lia

2003-01-01

Summarizes research investigating children's transition to primary school from Pacific early childhood centers in New Zealand. Key issues emerging from the review include continuity of Pacific Islands languages and culture between home, early childhood center, and school; home-school partnership; teachers' and parents' expectations regarding…

The carbon cycle revisited

NASA Technical Reports Server (NTRS)

Bolin, Bert; Fung, Inez

1992-01-01

Discussions during the Global Change Institute indicated a need to present, in some detail and as accurately as possible, our present knowledge about the carbon cycle, the uncertainties in this knowledge, and the reasons for these uncertainties. We discuss basic issues of internal consistency within the carbon cycle, and end by summarizing the key unknowns.

Implementing Positive Behavior Support with Chinese American Families: Enhancing Cultural Competence

ERIC Educational Resources Information Center

Wang, Mian; McCart, Amy; Turnbull, Ann P.

2007-01-01

In positive behavior support (PBS) practices, one critical issue involves helping professionals understand and respect the values of families from culturally diverse backgrounds. This article summarizes embedded cultural values of PBS represented in four key features of the PBS process: collaborative partnerships, functional assessment, contextual…

Reproductive issues in anorexia nervosa

PubMed Central

Hoffman, Elizabeth R; Zerwas, Stephanie C; Bulik, Cynthia M

2011-01-01

Despite a high prevalence of menstrual irregularities, women with anorexia nervosa are becoming pregnant. The physical and psychological demands of pregnancy and motherhood can represent an immense challenge for women already struggling with the medical and psychological stress of an eating disorder. This article summarizes key issues related to reproduction in women with anorexia nervosa, highlighting the importance of preconception counseling, adequate gestational weight gain, and sufficient pre- and post-natal nutrition. Postpartum issues including eating disorder symptom relapse, weight loss, breastfeeding, and risk of perinatal depression and anxiety are also discussed. PMID:22003362

Impact Assessment and Forecasts of Information and Telecommunications Technologies Applied to Education and Training: Volume II--Main Report and Issues Analyses. Analysis for the Orientation of the Work of Sector Actors in the Framework of DELTA.

ERIC Educational Resources Information Center

Commission of the European Communities, Brussels (Belgium).

This report, the second volume in a three volume set, summarizes the results of a study performed by the DELTA (Developing European Learning through Technological Advance) unit in parallel with the projects underway in the research and development Exploratory Action. The report identifies the key issues, associated requirements and options, and…

The Best of CAUSE/EFFECT: 1978-1991.

ERIC Educational Resources Information Center

Rudy, Julia A., Ed.

This issue of the higher education information technology magazine, CAUSE/EFFECT, presents in six articles six summaries of the best from this journal since 1978. The articles each summarize the writing done over the years in one of six key areas. The articles are as follows: (1) "Rise of Infrastructure" by Kenneth J. Klingenstein and…

Development of the Runway Incursion Advisory and Alerting System (RIAAS): Research Summary

NASA Technical Reports Server (NTRS)

Jones, Denise R. (Technical Monitor); Cassell, Rick

2005-01-01

This report summarizes research conducted on an aircraft based Runway Incursion Advisory and Alerting System (RIAAS) developed under a cooperative agreement between Rannoch Corporation and the NASA Langley Research Center. A summary of RIAAS is presented along with results from simulation and flight testing, safety benefits, and key technical issues.

An Update on Reading in the Content Areas: Social Constructionist Dimensions.

ERIC Educational Resources Information Center

Bean, Thomas W.

2002-01-01

Summarizes key findings from a previous review of reading research in which the author charted a paradigm shift in content area reading research from strategy validation studies in the 1980s to qualitative studies aimed at understanding sociocultural dimensions in teaching and learning. Comments on issues presenting themselves now, at the outset…

Herpetological conservation in northwestern North America

Treesearch

Deanna H. Olson

2009-01-01

Conservation of the 105 species of amphibians, reptiles, and turtles in the northwestern United States and western Canada is represented by a diverse mix of projects and programs across ten states, provinces, and territories. In this paper, 29 contributing authors review the status of herpetofauna by state, province or territory, and summarize the key issues, programs...

Southern Great Plains Rapid Ecoregional Assessment: pre-assessment report

USGS Publications Warehouse

Assal, Timothy J.; Melcher, Cynthia P.; Carr, Natasha B.

2015-01-01

An overview on the ecology and management issues for each Conservation Element is provided, including distribution and ecology, landscape structure and dynamics, and associated species of management concern affiliated with each Conservation Element. For each Conservation Element, effects of the Change Agents are described. An overview of potential key ecological attributes and potential Change Agents are summarized by conceptual models and tables. The tables provide an organizational framework and background information for evaluating the key ecological attributes and Change Agents in Phase II.

"Let Me Keep My Dead Husband's Sperm": Ethical Issues in Posthumous Reproduction.

PubMed

Panagiotopoulou, Nikoletta; Karavolos, Stamatios

2015-01-01

The feasibility of posthumous reproduction when the surviving partner is female has brought to light many ethical, moral, social, and legal issues. This review aims to summarize these issues and to assist clinicians who may be faced with such requests. A question list, used for health technologies assessment, was utilized in a question-answer approach as the review methodology. Of the 1,208 publications identified through a comprehensive literature search in biomedical, psychological, and ethical databases, 31 articles included arguments related to one or more questions from the predefined question set. Key stakeholders identified include the deceased, the requesting party, the resultant child, the physician, and society. Key ethical issues relevant to posthumous reproduction include the four traditional pillars of medical ethics--autonomy, beneficence, nonmaleficence, justice--as well as the stakeholders' rights and sociocultural attitudes. The ethical framework formulated by these issues has been incorporated in a clinical ethics decision-making tool that could prove useful to clinicians and decision makers. Copyright 2015 The Journal of Clinical Ethics. All rights reserved.

Key Issues in the Analysis of Remote Sensing Data: A report on the workshop

NASA Technical Reports Server (NTRS)

Swain, P. H. (Principal Investigator)

1981-01-01

The procedures of a workshop assessing the state of the art of machine analysis of remotely sensed data are summarized. Areas discussed were: data bases, image registration, image preprocessing operations, map oriented considerations, advanced digital systems, artificial intelligence methods, image classification, and improved classifier training. Recommendations of areas for further research are presented.

Computing the Average Square: An Agent-Based Introduction to Aspects of Current Psychometric Practice

ERIC Educational Resources Information Center

Stroup, Walter M.; Hills, Thomas; Carmona, Guadalupe

2011-01-01

This paper summarizes an approach to helping future educators to engage with key issues related to the application of measurement-related statistics to learning and teaching, especially in the contexts of science, mathematics, technology and engineering (STEM) education. The approach we outline has two major elements. First, students are asked to…

Educating America's Youth: What Makes a Difference. Child Trends Research Brief.

ERIC Educational Resources Information Center

Redd, Zakia; Brooks, Jennifer; McGarvey, Ayelish M.

Because an educated workforce is recognized as essential to ensuring competitiveness in a global economy, it is considered an issue of national concern how teens in the United States are faring educationally, especially compared with teens worldwide. This research brief summarizes the key findings from a larger review of more than 300 research…

Earthworms (Annelida: Oligochaeta) of the Columbia River basin assessment area.

Treesearch

Sam James

2000-01-01

Earthworms are key components of many terrestrial ecosystems; however, little is known of their ecology, distribution, and taxonomy in the eastern interior Columbia River basin assessment area (hereafter referred to as the basin assessment area). This report summarizes the main issues about the ecology of earthworms and their impact on the physical and chemical status...

Executive Summary of the 2000 External Environmental Scan and the Internal Environmental Scan Report Card: Key Issues for Planning.

ERIC Educational Resources Information Center

Beachler, Judith

This document summarizes both the 2000 External Environmental Scan and the 2000 Internal Environmental Scan Report Card for the Los Rios Community College District (LRCCD) (California). LRCCD consists of American River College (ARC), Consummes River College (CRC), and Sacramento City College (SCC). Report highlights include: (1) total headcount…

Mendel in the Modern Classroom

ERIC Educational Resources Information Center

Smith, Mike U.; Gericke, Niklas M.

2015-01-01

Mendel is an icon in the history of genetics and part of our common culture and modern biology instruction. The aim of this paper is to summarize the place of Mendel in the modern biology classroom. In the present article we will identify key issues that make Mendel relevant in the classroom today. First, we recount some of the historical…

Commentary: Overview of Developmental Perspectives on Creativity and the Realization of Potential

ERIC Educational Resources Information Center

Runco, Mark A.

2016-01-01

The articles in this issue of "New Directions for Child and Adolescent Development" nicely summarize recent findings about creativity and development. This commentary underscores some of the key ideas and puts them into a larger context (i.e., the corpus of creativity research). It pinpoints areas of agreement (e.g., the need to take…

Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14–15 September 2015

PubMed Central

Williams, David J; Archer, Richard; Archibald, Peter; Bantounas, Ioannis; Baptista, Ricardo; Barker, Roger; Barry, Jacqueline; Bietrix, Florence; Blair, Nicholas; Braybrook, Julian; Campbell, Jonathan; Canham, Maurice; Chandra, Amit; Foldes, Gabor; Gilmanshin, Rudy; Girard, Mathilde; Gorjup, Erwin; Hewitt, Zöe; Hourd, Paul; Hyllner, Johan; Jesson, Helen; Kee, Jasmin; Kerby, Julie; Kotsopoulou, Nina; Kowalski, Stanley; Leidel, Chris; Marshall, Damian; Masi, Louis; McCall, Mark; McCann, Conor; Medcalf, Nicholas; Moore, Harry; Ozawa, Hiroki; Pan, David; Parmar, Malin; Plant, Anne L; Reinwald, Yvonne; Sebastian, Sujith; Stacey, Glyn; Thomas, Robert J; Thomas, Dave; Thurman-Newell, Jamie; Turner, Marc; Vitillo, Loriana; Wall, Ivan; Wilson, Alison; Wolfrum, Jacqueline; Yang, Ying; Zimmerman, Heiko

2016-01-01

This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to demonstrate equivalence of product after a process change; a recent publication states that this ‘may be difficult for cell-based medicinal products’. Therefore a well-managed change process is required which needs access to good science and regulatory advice and developers are encouraged to seek help early. The workshop shared current thinking and best practice and allowed the definition of key research questions. The intent of this report is to summarize the key issues and the consensus reached on each of these by the expert delegates. PMID:27404768

Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015.

PubMed

Williams, David J; Archer, Richard; Archibald, Peter; Bantounas, Ioannis; Baptista, Ricardo; Barker, Roger; Barry, Jacqueline; Bietrix, Florence; Blair, Nicholas; Braybrook, Julian; Campbell, Jonathan; Canham, Maurice; Chandra, Amit; Foldes, Gabor; Gilmanshin, Rudy; Girard, Mathilde; Gorjup, Erwin; Hewitt, Zöe; Hourd, Paul; Hyllner, Johan; Jesson, Helen; Kee, Jasmin; Kerby, Julie; Kotsopoulou, Nina; Kowalski, Stanley; Leidel, Chris; Marshall, Damian; Masi, Louis; McCall, Mark; McCann, Conor; Medcalf, Nicholas; Moore, Harry; Ozawa, Hiroki; Pan, David; Parmar, Malin; Plant, Anne L; Reinwald, Yvonne; Sebastian, Sujith; Stacey, Glyn; Thomas, Robert J; Thomas, Dave; Thurman-Newell, Jamie; Turner, Marc; Vitillo, Loriana; Wall, Ivan; Wilson, Alison; Wolfrum, Jacqueline; Yang, Ying; Zimmerman, Heiko

2016-07-01

This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to demonstrate equivalence of product after a process change; a recent publication states that this 'may be difficult for cell-based medicinal products'. Therefore a well-managed change process is required which needs access to good science and regulatory advice and developers are encouraged to seek help early. The workshop shared current thinking and best practice and allowed the definition of key research questions. The intent of this report is to summarize the key issues and the consensus reached on each of these by the expert delegates.

Annual Report To Congress. Department of Energy Activities Relating to the Defense Nuclear Facilities Safety Board, Calendar Year 2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2004-02-28

The Department of Energy (Department) submits an Annual Report to Congress each year detailing the Department’s activities relating to the Defense Nuclear Facilities Safety Board (Board), which provides advice and recommendations to the Secretary of Energy (Secretary) regarding public health and safety issues at the Department’s defense nuclear facilities. In 2003, the Department continued ongoing activities to resolve issues identified by the Board in formal recommendations and correspondence, staff issue reports pertaining to Department facilities, and public meetings and briefings. Additionally, the Department is implementing several key safety initiatives to address and prevent safety issues: safety culture and review ofmore » the Columbia accident investigation; risk reduction through stabilization of excess nuclear materials; the Facility Representative Program; independent oversight and performance assurance; the Federal Technical Capability Program (FTCP); executive safety initiatives; and quality assurance activities. The following summarizes the key activities addressed in this Annual Report.« less

Citizenship Education in Latin America: Priorities of School Curricula. IBE Working Papers on Curriculum Issues No. 14

ERIC Educational Resources Information Center

Cox, Cristián; Bascopé, Martín; Castillo, Juan Carlos; Miranda, Daniel; Bonhomme, Macarena

2015-01-01

What are the key contents related to democratic life in the curricula of civic and citizenship education in Latin American countries? What values and dimensions are most emphasized? This document summarizes the results of a comparative analysis of civic/citizenship curricula for primary and secondary education in six Latin American countries…

Effects of food marketing to kids: I'm lovin' it?

PubMed

Salinsky, Eileen

2006-08-15

This issue brief reviews key findings and recommendations from the Institute of Medicine study on food marketing and its effects on childhood obesity. The brief describes the childhood obesity epidemic, discusses key trends associated with rising childhood obesity rates, and considers the relative role of marketing practices on diet and obesity within the broader context of complex contributory factors. The brief also summarizes the current legal framework for regulating marketing directed at children;discusses voluntary, self-regulatory mechanisms; and highlights proposals to re-orient marketing practices to combat childhood obesity.

Persufflation (gaseous oxygen perfusion) as a method of heart preservation.

PubMed

Suszynski, Thomas M; Rizzari, Michael D; Scott, William E; Eckman, Peter M; Fonger, James D; John, Ranjit; Chronos, Nicolas; Tempelman, Linda A; Sutherland, David E R; Papas, Klearchos K

2013-04-22

Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggests that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.

An Independent Scientific Assessment of Well Stimulation in California Volume III

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jane C.S. Long; Laura C. Feinstein; Birkholzer, Jens

This study is issued in three volumes. Volume I, issued in January 2015, describes how well stimulation technologies work, how and where operators deploy these technologies for oil and gas production in California, and where they might enable production in the future. Volume II, issued in July 2015, discusses how well stimulation could affect water, atmosphere, seismic activity, wildlife and vegetation, and human health. Volume II reviews available data, and identifies knowledge gaps and alternative practices that could avoid or mitigate these possible impacts. Volume III, this volume, presents case studies that assess environmental issues and qualitative risks for specificmore » geographic regions. The Summary Report summarizes key findings, conclusions and recommendations of all three volumes.« less

An Independent Scientific Assessment of Well Stimulation in California Volume II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jane C.S. Long; Laura C. Feinstein; Corinne E. Bachmann

This study is issued in three volumes. Volume I, issued in January 2015, describes how well stimulation technologies work, how and where operators deploy these technologies for oil and gas production in California, and where they might enable production in the future. Volume II, the present volume, discusses how well stimulation could affect water, atmosphere, seismic activity, wildlife and vegetation, and human health. Volume II reviews available data, and identifies knowledge gaps and alternative practices that could avoid or mitigate these possible impacts. Volume III, also issued in July 2015, presents case studies that assess environmental issues and qualitative risksmore » for specific geographic regions. A final Summary Report summarizes key findings, conclusions and recommendations of all three volumes.« less

The Role of the Institutional Researcher in a Sex Discrimination Suit. AIR Forum 1981 Paper.

ERIC Educational Resources Information Center

Simpson, William A.; Rosenthal, William H.

Steps in a class action suit charging prejudicial treatment of a minority group by a college or university are summarized, and attention is directed to how the plaintiffs can use the institution's own data to establish a prima facie case for disparate treatment. The key legal issues are indicated, and typical data and statistical exhibits that an…

Perceptual Audio Hashing Functions

NASA Astrophysics Data System (ADS)

Özer, Hamza; Sankur, Bülent; Memon, Nasir; Anarım, Emin

2005-12-01

Perceptual hash functions provide a tool for fast and reliable identification of content. We present new audio hash functions based on summarization of the time-frequency spectral characteristics of an audio document. The proposed hash functions are based on the periodicity series of the fundamental frequency and on singular-value description of the cepstral frequencies. They are found, on one hand, to perform very satisfactorily in identification and verification tests, and on the other hand, to be very resilient to a large variety of attacks. Moreover, we address the issue of security of hashes and propose a keying technique, and thereby a key-dependent hash function.

Proceedings of the Real-Time Systems Engineering Workshop

DTIC Science & Technology

2001-08-01

real - time systems engineering. The workshop was held as part of the SEI Symposium in...Washington, DC, during September 2000. The objective of the workshop was to identify key issues and obtain feedback from attendees concerning real - time systems engineering...and interoperability. This report summarizes the workshop in terms of foundation, management, and technical topics, and it contains a discussion related to developing a community of interest for real - time systems

A Summary of Two Studies on Pay Disparities by Race and Gender: Evidence from the 1988 and 1993 NCES Surveys.

ERIC Educational Resources Information Center

Toutkoushian, Robert K.

This paper summarizes the key findings of two separate studies of issues pertaining to pay equity for faculty by race and gender. Data were obtained from the 1988 and 1993 National Studies of Postsecondary Faculty, which contain information on 11,013 and 31,354 faculty, respectively. It was found that the unexplained wage gap between men and women…

Responses to canopy loss and debris deposition in a tropical forest ecosystem: Synthesis from an experimental manipulation simulating effects of hurricane disturbance

Treesearch

A.B. Shiels; Grizelle Gonzalez; M.R. Willig

2014-01-01

Hurricanes, cyclones, or typhoons are intense and broad-scale disturbances that affect many island and coastal ecosystems throughout the world. We summarize the findings of the articles that compose this special issue of Forest Ecology and Management, which focuses on a manipulative experiment (the Canopy Trimming Experiment, CTE) that simulates two key aspects of...

Scalable gastroscopic video summarization via similar-inhibition dictionary selection.

PubMed

Wang, Shuai; Cong, Yang; Cao, Jun; Yang, Yunsheng; Tang, Yandong; Zhao, Huaici; Yu, Haibin

2016-01-01

This paper aims at developing an automated gastroscopic video summarization algorithm to assist clinicians to more effectively go through the abnormal contents of the video. To select the most representative frames from the original video sequence, we formulate the problem of gastroscopic video summarization as a dictionary selection issue. Different from the traditional dictionary selection methods, which take into account only the number and reconstruction ability of selected key frames, our model introduces the similar-inhibition constraint to reinforce the diversity of selected key frames. We calculate the attention cost by merging both gaze and content change into a prior cue to help select the frames with more high-level semantic information. Moreover, we adopt an image quality evaluation process to eliminate the interference of the poor quality images and a segmentation process to reduce the computational complexity. For experiments, we build a new gastroscopic video dataset captured from 30 volunteers with more than 400k images and compare our method with the state-of-the-arts using the content consistency, index consistency and content-index consistency with the ground truth. Compared with all competitors, our method obtains the best results in 23 of 30 videos evaluated based on content consistency, 24 of 30 videos evaluated based on index consistency and all videos evaluated based on content-index consistency. For gastroscopic video summarization, we propose an automated annotation method via similar-inhibition dictionary selection. Our model can achieve better performance compared with other state-of-the-art models and supplies more suitable key frames for diagnosis. The developed algorithm can be automatically adapted to various real applications, such as the training of young clinicians, computer-aided diagnosis or medical report generation. Copyright © 2015 Elsevier B.V. All rights reserved.

Telemental Health for Children and Adolescents: An Overview of Legal, Regulatory, and Risk Management Issues.

PubMed

Kramer, Gregory M; Luxton, David D

2016-04-01

The use of technology to provide telemental healthcare continues to increase; however, little has been written about the legal and regulatory issues involved in providing this form of care to children and adolescents. This article reviews existing laws and regulations to summarize the risk management issues relevant to providing telemental healthcare to children and adolescents. There are several legal and regulatory areas in which telemental health clinicians need to have awareness. These areas include: 1) Licensure, 2) malpractice liability, 3) credentialing and privileging, 4) informed consent, 5) security and privacy, and 6) emergency management. Although legal and regulatory challenges remain in providing telemental healthcare to children and adolescents, it is possible to overcome these challenges with knowledge of the issues and appropriate risk management strategies. We provide general knowledge of these key legal and regulatory issues, along with some risk management recommendations.

Reaching kids: partnering with preschools and schools to improve children's health.

PubMed

2009-11-01

As part of its continuing mission to serve trustees and staff of health foundations and corporate giving programs, Grantmakers In Health (GIH) convened a group of grantmakers and education experts on May 27, 2009, for an informative discussion about ways in which preschools and schools are working to improve outcomes related to children's health. The Issue Dialogue Reaching Kids: Partnering with Preschools and Schools to Improve Children's Health synthesized the latest research on health-related issues affecting children's educational outcomes. It also provided illustrative examples of foundation-driven initiatives aimed at promoting collaborations between the health and education sectors to improve children's health and development outcomes. This Issue Brief summarizes background materials compiled for the meeting and highlights key themes and findings that emerged from the day's discussion among meeting participants.

Tangible resources for preparing patients for antiviral therapy for chronic hepatitis C.

PubMed

Bonner, Jason E; Barritt, A Sidney; Fried, Michael W; Evon, Donna M

2012-06-01

Chronic hepatitis C (HCV) infected patients with coexisting mental health and/or substance abuse issues face significant barriers to treatment and are often deferred. This paper sought to highlight critical pre-treatment strategies and provide tangible resources for HCV clinicians to facilitate preparation and successful treatment of these patients. Guided by the clinical experience of our liver center, a large, tertiary academic medical center, and informed by the extant literature, we summarize pre-treatment strategies and specific resources and recommendations for HCV providers. Four key pre-treatment strategies include: 1) screening for mental health/substance abuse issues using brief, reliable and validated instruments; 2) locating and establishing collaborative care with mental health and substance abuse specialists; 3) using a motivational interviewing communication style; and 4) addressing adherence-related issues. HCV clinicians are in a unique position to prepare patients with coexisting mental health and/or substance abuse issues for antiviral therapy.

An Overview of Key Indicators and Evaluation Tools for Assessing Housing Quality: A Literature Review

NASA Astrophysics Data System (ADS)

Sinha, Rajan Chandra; Sarkar, Satyaki; Mandal, Nikhil Ranjan

2017-09-01

The issue of the housing quality has been addressed for various stakeholders at different levels. There exist varied opinion about its measurability and possible applications. Thus the study is carried out to have an insight into the concept of housing quality and its relevance in the changing demographics, technological, socio-economic and socio-cultural conditions. This study attempts to summarize the literature that addresses past research concerned with factors related to housing quality, its measurement methodology and critically examines the broad key indicators identified to have impact upon enhancing the housing quality. This work discusses the recent techniques which are extensively used for analysis of housing quality.

The RE-AIM Framework: A Systematic Review of Use Over Time

PubMed Central

Shoup, Jo Ann; Glasgow, Russell E.

2013-01-01

We provided a synthesis of use, summarized key issues in applying, and highlighted exemplary applications in the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. We articulated key RE-AIM criteria by reviewing the published literature from 1999 to 2010 in several databases to describe the application and reporting on various RE-AIM dimensions. After excluding nonempirical articles, case studies, and commentaries, 71 articles were identified. The most frequent publications were on physical activity, obesity, and disease management. Four articles reported solely on 1 dimension compared with 44 articles that reported on all 5 dimensions of the framework. RE-AIM was broadly applied, but several criteria were not reported consistently. PMID:23597377

Toward Impactful Collaborations on Computing and Mental Health

PubMed Central

Dinakar, Karthik; Picard, Rosalind; Christensen, Helen; Torous, John

2018-01-01

We describe an initiative to bring mental health researchers, computer scientists, human-computer interaction researchers, and other communities together to address the challenges of the global mental ill health epidemic. Two face-to-face events and one special issue of the Journal of Medical Internet Research were organized. The works presented in these events and publication reflect key state-of-the-art research in this interdisciplinary collaboration. We summarize the special issue articles and contextualize them to present a picture of the most recent research. In addition, we describe a series of collaborative activities held during the second symposium and where the community identified 5 challenges and their possible solutions. PMID:29426812

Effects of gravity perturbation on developing animal systems

NASA Technical Reports Server (NTRS)

Malacinski, G. M.; Neff, A. W.

1986-01-01

The use of developing animal systems to analyze the effects of microgravity on animals is discussed. Some of the key features of developing systems, especially embryos, are reviewed and relevant space data are summarized. Issues to be addressed in the design of future space experiments are discussed. It is noted that an embryo which exhibits ground based gravity effects should be selected for use as a model system and individual variation in gravity response among batches of embryos should be taken into account.

Dynamic Loading and Characterization of Fiber-Reinforced Composites

NASA Astrophysics Data System (ADS)

Sierakowski, Robert L.; Chaturvedi, Shive K.

1997-02-01

Emphasizing polymer based fiber-reinforced composites, this book is designed to provide readers with a significant understanding of the complexities involved in characterizing dynamic events and the corresponding response of advanced fiber composite materials and structures. These elements include dynamic loading devices, material properties characterization, analytical and experimental techniques to assess the damage and failure modes associated with various dynamic loading events. Concluding remarks are presented throughout the text which summarize key points and raise issues related to important research needed.

What's in a Name? Recent Key Projects of the Committee on Organization and Delivery of Burn Care.

PubMed

Hickerson, William L; Ryan, Colleen M; Conlon, Kathe M; Harrington, David T; Foster, Kevin; Schwartz, Suzanne; Iyer, Narayan; Jeschke, Marc; Haller, Herbert L; Faucher, Lee D; Arnoldo, Brett D; Jeng, James C

2015-01-01

The Committee for the Organization and Delivery of Burn Care (ODBC) was charged by President Palmieri and the American Burn Association (ABA) Board of Directors with presenting a plenary session at the 45th Meeting of the ABA in Palm Springs, CA, in 2013. The objective of the plenary session was to inform the membership about the wide range of the activities performed by the ODBC committee. The hope was that this session would encourage active involvement within the ABA as a means to improve the delivery of future burn care. Selected current activities were summarized by key leaders of each project and highlighted in the plenary session. The history of the committee, current projects in disaster management, regionalization, best practice guidelines, federal partnerships, product development, new technologies, electronic medical records, and manpower issues in the burn workforce were summarized. The ODBC committee is a keystone committee of the ABA. It is tasked by the ABA leadership with addressing and leading progress in many areas that constitute current challenges in the delivery of burn care.

Progress on first-principles-based materials design for hydrogen storage.

PubMed

Park, Noejung; Choi, Keunsu; Hwang, Jeongwoon; Kim, Dong Wook; Kim, Dong Ok; Ihm, Jisoon

2012-12-04

This article briefly summarizes the research activities in the field of hydrogen storage in sorbent materials and reports our recent works and future directions for the design of such materials. Distinct features of sorption-based hydrogen storage methods are described compared with metal hydrides and complex chemical hydrides. We classify the studies of hydrogen sorbent materials in terms of two key technical issues: (i) constructing stable framework structures with high porosity, and (ii) increasing the binding affinity of hydrogen molecules to surfaces beyond the usual van der Waals interaction. The recent development of reticular chemistry is summarized as a means for addressing the first issue. Theoretical studies focus mainly on the second issue and can be grouped into three classes according to the underlying interaction mechanism: electrostatic interactions based on alkaline cations, Kubas interactions with open transition metals, and orbital interactions involving Ca and other nontransitional metals. Hierarchical computational methods to enable the theoretical predictions are explained, from ab initio studies to molecular dynamics simulations using force field parameters. We also discuss the actual delivery amount of stored hydrogen, which depends on the charging and discharging conditions. The usefulness and practical significance of the hydrogen spillover mechanism in increasing the storage capacity are presented as well.

Progress on first-principles-based materials design for hydrogen storage

PubMed Central

Park, Noejung; Choi, Keunsu; Hwang, Jeongwoon; Kim, Dong Wook; Kim, Dong Ok; Ihm, Jisoon

2012-01-01

This article briefly summarizes the research activities in the field of hydrogen storage in sorbent materials and reports our recent works and future directions for the design of such materials. Distinct features of sorption-based hydrogen storage methods are described compared with metal hydrides and complex chemical hydrides. We classify the studies of hydrogen sorbent materials in terms of two key technical issues: (i) constructing stable framework structures with high porosity, and (ii) increasing the binding affinity of hydrogen molecules to surfaces beyond the usual van der Waals interaction. The recent development of reticular chemistry is summarized as a means for addressing the first issue. Theoretical studies focus mainly on the second issue and can be grouped into three classes according to the underlying interaction mechanism: electrostatic interactions based on alkaline cations, Kubas interactions with open transition metals, and orbital interactions involving Ca and other nontransitional metals. Hierarchical computational methods to enable the theoretical predictions are explained, from ab initio studies to molecular dynamics simulations using force field parameters. We also discuss the actual delivery amount of stored hydrogen, which depends on the charging and discharging conditions. The usefulness and practical significance of the hydrogen spillover mechanism in increasing the storage capacity are presented as well. PMID:23161910

Human Health Effects of Trichloroethylene: Key Findings and Scientific Issues

PubMed Central

Jinot, Jennifer; Scott, Cheryl Siegel; Makris, Susan L.; Cooper, Glinda S.; Dzubow, Rebecca C.; Bale, Ambuja S.; Evans, Marina V.; Guyton, Kathryn Z.; Keshava, Nagalakshmi; Lipscomb, John C.; Barone, Stanley; Fox, John F.; Gwinn, Maureen R.; Schaum, John; Caldwell, Jane C.

2012-01-01

Background: In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. Objectives: We summarized the key findings and scientific issues regarding the human health effects of TCE in the U.S. EPA’s toxicological review. Methods: In this assessment we synthesized and characterized thousands of epidemiologic, experimental animal, and mechanistic studies, and addressed several key scientific issues through modeling of TCE toxicokinetics, meta-analyses of epidemiologic studies, and analyses of mechanistic data. Discussion: Toxicokinetic modeling aided in characterizing the toxicological role of the complex metabolism and multiple metabolites of TCE. Meta-analyses of the epidemiologic data strongly supported the conclusions that TCE causes kidney cancer in humans and that TCE may also cause liver cancer and non-Hodgkin lymphoma. Mechanistic analyses support a key role for mutagenicity in TCE-induced kidney carcinogenicity. Recent evidence from studies in both humans and experimental animals point to the involvement of TCE exposure in autoimmune disease and hypersensitivity. Recent avian and in vitro mechanistic studies provided biological plausibility that TCE plays a role in developmental cardiac toxicity, the subject of substantial debate due to mixed results from epidemiologic and rodent studies. Conclusions: TCE is carcinogenic to humans by all routes of exposure and poses a potential human health hazard for noncancer toxicity to the central nervous system, kidney, liver, immune system, male reproductive system, and the developing embryo/fetus. PMID:23249866

Wyoming Basin Rapid Ecoregional Assessment

USGS Publications Warehouse

Carr, Natasha B.; Melcher, Cynthia P.

2015-08-28

We evaluated Management Questions (Core and Integrated) for each species and community for the Wyoming Basin REA. Core Management Questions address primary management issues, including (1) where is the Conservation Element, and what are its key ecological attributes (characteristics of species and communities that may affect their long-term persistence or viability); (2) what and where are the Change Agents; and (3) how do the Change Agents affect the key ecological attributes? Integrated Management Questions synthesize the Core Management Questions as follows: (1) where are the areas with high landscape-level ecological values; (2) where are the areas with high landscape-level risks; and (3) where are the potential areas for conservation, restoration, and development? The associated maps and key findings for each Management Question are summarized for each Conservation Element in individual chapters. Additional chapters on landscape intactness and an REA synthesis are included.

Critical transport issues for improving the performance of aqueous redox flow batteries

NASA Astrophysics Data System (ADS)

Zhou, X. L.; Zhao, T. S.; An, L.; Zeng, Y. K.; Wei, L.

2017-01-01

As the fraction of electricity generated from intermittent renewable sources (such as solar and wind) grows, developing reliable energy storage technologies to store electrical energy in large scale is of increasing importance. Redox flow batteries are now enjoying a renaissance and regarded as a leading technology in providing a well-balanced solution for current daunting challenges. In this article, state-of-the-art studies of the complex multicomponent transport phenomena in aqueous redox flow batteries, with a special emphasis on all-vanadium redox flow batteries, are reviewed and summarized. Rather than elaborating on the details of previous experimental and numerical investigations, this article highlights: i) the key transport issues in each battery's component that need to be tackled so that the rate capability and cycling stability of flow batteries can be significantly improved, ii) the basic mechanisms that control the active species/ion/electron transport behaviors in each battery's component, and iii) the key experimental and numerical findings regarding the correlations between the multicomponent transport processes and battery performance.

Commentary: Pediatric eHealth Interventions: Common Challenges During Development, Implementation, and Dissemination

PubMed Central

Steele, Ric G.; Connelly, Mark A.; Palermo, Tonya M.; Ritterband, Lee M.

2014-01-01

Objective To provide an overview of common challenges that pediatric eHealth researchers may encounter when planning, developing, testing, and disseminating eHealth interventions along with proposed solutions for addressing these challenges. Methods The article draws on the existing eHealth literature and the authors’ collective experience in pediatric eHealth research. Results and conclusions The challenges associated with eHealth interventions and their proposed solutions are multifaceted and cut across a number of areas from eHealth program development through dissemination. Collaboration with a range of individuals (e.g., multidisciplinary colleagues, commercial entities, primary stakeholders) is the key to eHealth intervention success. To ensure adequate resources for design, development, and planning for sustainability, a number of public and private sources of funding are available. A study design that addresses ethical concerns and security issues is critical to ensure scientific integrity and intervention dissemination. Table I summarizes key issues to consider during eHealth intervention development, testing, and dissemination. PMID:24816766

Digital telephony analysis model and issues

NASA Astrophysics Data System (ADS)

Keuthan, Lynn M.

1995-09-01

Experts in the fields of digital telephony and communications security have stated the need for an analytical tool for evaluating complex issues. Some important policy issues discussed by experts recently include implementing digital wire-taps, implementation of the 'Clipper Chip', required registration of encryption/decryption keys, and export control of cryptographic equipment. Associated with the implementation of these policies are direct costs resulting from implementation, indirect cost benefits from implementation, and indirect costs resulting from the risks of implementation or factors reducing cost benefits. Presented herein is a model for analyzing digital telephony policies and systems and their associated direct costs and indirect benefit and risk factors. In order to present the structure of the model, issues of national importance and business-related issues are discussed. The various factors impacting the implementation of the associated communications systems and communications security are summarized, and various implementation tradeoffs are compared based on economic benefits/impact. The importance of the issues addressed herein, as well as other digital telephony issues, has greatly increased with the enormous increases in communication system connectivity due to the advance of the National Information Infrastructure.

The gap between law and ethics in human embryonic stem cell research: overcoming the effect of U.S. federal policy on research advances and public benefit.

PubMed

Taylor, Patrick L

2005-10-01

Key ethical issues arise in association with the conduct of stem cell research by research institutions in the United States. These ethical issues, summarized in detail, receive no adequate translation into federal laws or regulations, also described in this article. U.S. Federal policy takes a passive approach to these ethical issues, translating them simply into limitations on taxpayer funding, and foregoes scientific and ethical leadership while protecting intellectual property interests through a laissez faire approach to stem cell patents and licenses. Those patents and licenses, far from being scientifically and ethically neutral in effect, virtually prohibit commercially sponsored research that could otherwise be a realistic alternative to the federal funding gap. The lack of federal funding and related data-sharing principles, combined with the effect of U.S. patent policy, the lack of key agency guidance, and the proliferation of divergent state laws arising from the lack of Federal leadership, significantly impede ethical stem cell research in the United States, without coherently supporting any consensus ethical vision. Research institutions must themselves implement steps, described in the article, to integrate addressing ethical review with the many legal compliance issues U.S. federal and state laws create.

Analysis of S-nitrosothiols via Copper Cysteine (2C) and Copper Cysteine - Carbon Monoxide (3C) Methods

PubMed Central

Rogers, Stephen C.; Gibbons, Lindsey B.; Griffin, Sherraine; Doctor, Allan

2012-01-01

This chapter summarizes the principles of RSNO measurement in the gas phase, utilizing ozone-based chemiluminescence and the copper cysteine (2C) ± carbon monoxide (3C) reagent. Although an indirect method for quantifying RSNOs, this assay represents one of the most robust methodologies available. It exploits the NO• detection sensitivity of ozone based chemiluminscence, which is within the range required to detect physiological concentrations of RSNO metabolites. Additionally, the specificity of the copper cysteine (2C and 3C) reagent for RSNOs negates the need for sample pretreatment, thereby minimizing the likelihood of sample contamination (false positive results), NO species inter-conversion, or the loss of certain highly labile RSNO species. Herein, we outline the principles of this methodology, summarizing key issues, potential pitfalls and corresponding solutions. PMID:23116707

Management of hereditary antithrombin deficiency in pregnancy.

PubMed

James, Andra H; Bates, Shannon M; Bauer, Kenneth A; Branch, Ware; Mann, Kenneth; Paidas, Michael; Silverman, Neil; Konkle, Barbara A

2017-09-01

Antithrombin (AT) deficiency is a high-risk thrombophilia and a rare condition. Despite full anticoagulation during pregnancy and the postpartum period, women with AT deficiency may still be vulnerable to developing venous thromboembolism (VTE), including fatal events. There is limited guidance on the management of AT deficiency in pregnancy, including the role of AT concentrates. Following a comprehensive review of the state of the art with respect to recommendations and guidelines, our expert panel in maternal-fetal medicine, hematology and basic science reached consensus on key issues in the recognition and management of AT deficiency in pregnancy. This paper summarizes the state of the art and summarizes what we believe are best practices with special emphasis on a multidisciplinary approach involving obstetrics and hematology in the care of women with AT deficiency. Copyright © 2017 Elsevier Ltd. All rights reserved.

Assessing the American Association of Neuroscience Nurses' Progress on the Institute of Medicine Report.

PubMed

Madden, Lori Kennedy; Hundley, Lynn; Summers, Debbie; Villanueva, Nancy; Walter, Suzy Mascaro

2017-06-01

The American Association of Neuroscience Nurses (AANN) has worked toward meeting the challenges and addressing the key messages from the 2010 Institute of Medicine report on the future of nursing. In 2012, AANN developed an article summarizing how the association has addressed key issues. Since that time, new recommendations have been made to advance nursing, and AANN has updated its strategic plan. The AANN has assessed organizational progress in these initiatives in a 2017 white paper. This process included review of plans since the initial report and proposal of further efforts the organization can make in shaping the future of neuroscience nursing. The purpose of this manuscript is to provide an overview of the AANN white paper.

Environmental Quality and the U.S. Power Sector: Air Quality, Land Use and Environmental Justice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Massetti, Emanuele; Brown, Marilyn Ann; Lapsa, Melissa Voss

This baseline report summarizes key environmental quality issues associated with electricity generation, transmission, distribution, and end use in the United States. Its scope includes non-greenhouse gas air pollution (i.e., sulfur dioxide, nitrogen oxides, particulate matter and hazardous air pollutants), land use, water pollution, ecological impacts, human health, and environmental justice. The discussion characterizes both current impacts and recent trends, as well as assessments of key drivers of change. For example, the air emissions section includes a quantitative decomposition analysis of the drivers of change in sulfur dioxide emissions reductions from coal-fired power plants. The report is divided into four topicalmore » sections: air emissions, land use and ecology, water quality, and environmental justice.« less

Introduction to the Wetland Book 1: Wetland structure and function, management, and nethods

USGS Publications Warehouse

Davidson, Nick C.; Middleton, Beth A.; McInnes, Robert J.; Everard, Mark; Irvine, Kenneth; Van Dam, Anne A.; Finlayson, C. Max; Finlayson, C. Max; Everard, Mark; Irvine, Kenneth; McInnes, Robert J.; Middleton, Beth A.; Van Dam, Anne A.; Davidson, Nick C.

2016-01-01

The Wetland Book 1 is designed as a ‘first port-of-call’ reference work for information on the structure and functions of wetlands, current approaches to wetland management, and methods for researching and understanding wetlands. Contributions by experts summarize key concepts, orient the reader to the major issues, and support further research on such issues by individuals and multidisciplinary teams. The Wetland Book 1 is organized in three parts - Wetland structure and function; Wetland management; and Wetland methods - each of which is divided into a number of thematic Sections. Each Section starts with one or more overview chapters, supported by chapters providing further information and case studies on different aspects of the theme.

Games for health conference 2004: issues, trends, and needs unique to games for health.

PubMed

Howell, Kay

2005-04-01

The first-ever Games for Health Conference (Madison, WI, September 16-17, 2004) identified issues, trends, and needs unique to games for healthcare. More than 130 doctors, educators, therapists, and game makers gathered to share experiences particular to the health industry, health practitioners, and patient treatment. Co-sponsored by Games for Health, Project of the Serious Games Initiative, the Academic ADL Co-Lab, and the Federation of American Scientists, the conference highlighted applications for direct patient care and therapy, as well as health education, policy, and management ideas. This paper presents key concepts from the conference's panel discussions and summarizes successful projects demonstrated at the conference that can serve as models for the field.

Overview of research addressing ethical dimensions of participation in traumatic stress studies: autonomy and beneficence.

PubMed

Newman, Elana; Kaloupek, Danny

2009-12-01

One element of the design of human research studies is ethically informed decision-making. Key issues include the safety, costs, and benefits of participation. Historically, much of this decision-making was based on opinion rather than formal evidence. Recently, however, investigators in the traumatic stress field have begun to collect data that are relevant to these decisions. In this article, the authors focus on issues emanating from the ethical concepts of autonomy and respect for persons and beneficence and nonmaleficence, and then summarize relevant evidence from studies with trauma-exposed individuals. Discussion addresses implications of this evidence for research practice and policy, and identifies some potentially informative data collections opportunities for future trauma studies.

Hierarchical video summarization

NASA Astrophysics Data System (ADS)

Ratakonda, Krishna; Sezan, M. Ibrahim; Crinon, Regis J.

1998-12-01

We address the problem of key-frame summarization of vide in the absence of any a priori information about its content. This is a common problem that is encountered in home videos. We propose a hierarchical key-frame summarization algorithm where a coarse-to-fine key-frame summary is generated. A hierarchical key-frame summary facilitates multi-level browsing where the user can quickly discover the content of the video by accessing its coarsest but most compact summary and then view a desired segment of the video with increasingly more detail. At the finest level, the summary is generated on the basis of color features of video frames, using an extension of a recently proposed key-frame extraction algorithm. The finest level key-frames are recursively clustered using a novel pairwise K-means clustering approach with temporal consecutiveness constraint. We also address summarization of MPEG-2 compressed video without fully decoding the bitstream. We also propose efficient mechanisms that facilitate decoding the video when the hierarchical summary is utilized in browsing and playback of video segments starting at selected key-frames.

The neural and computational bases of semantic cognition.

PubMed

Ralph, Matthew A Lambon; Jefferies, Elizabeth; Patterson, Karalyn; Rogers, Timothy T

2017-01-01

Semantic cognition refers to our ability to use, manipulate and generalize knowledge that is acquired over the lifespan to support innumerable verbal and non-verbal behaviours. This Review summarizes key findings and issues arising from a decade of research into the neurocognitive and neurocomputational underpinnings of this ability, leading to a new framework that we term controlled semantic cognition (CSC). CSC offers solutions to long-standing queries in philosophy and cognitive science, and yields a convergent framework for understanding the neural and computational bases of healthy semantic cognition and its dysfunction in brain disorders.

Hybrid Organic/Inorganic Nanocomposites for Photovoltaic Cells

PubMed Central

Liu, Ruchuan

2014-01-01

Inorganic/organic hybrid solar cells have attracted a lot of interest due to their potential in combining the advantages of both components. To understand the key issues in association with photoinduced charge separation/transportation processes and to improve overall power conversion efficiency, various combinations with nanostructures of hybrid systems have been investigated. Here, we briefly review the structures of hybrid nanocomposites studied so far, and attempt to associate the power conversion efficiency with these nanostructures. Subsequently, we are then able to summarize the factors for optimizing the performance of inorganic/organic hybrid solar cells. PMID:28788591

Satellite Power System. Concept development and evaluation program, volume 6: Construction and operations

NASA Technical Reports Server (NTRS)

Benson, H.; Jenkins, L. M.

1981-01-01

The construction, operation, and maintenance requirements for a solar power satellite, including the space and ground systems, are reviewed. The basic construction guidelines are explained, and construction location options are discussed. The space construction tasks, equipment, and base configurations are discussed together with the operations required to place a solar power satellite in geosynchronous orbit. A rectenna construction technique is explained, and operation with the grid is defined. Maintenance requirements are summarized for the entire system. Key technology issues required for solar power satellite construction operations are defined.

Data management issues in mobile ad hoc networks

PubMed Central

HARA, Takahiro

2017-01-01

Research on mobile ad hoc networks (MANETs) has become a hot research topic since the middle 1990’s. Over the first decade, most research focused on networking techniques, ignoring data management issues. We, however, realized early the importance of data management in MANETs, and have been conducting studies in this area for 15 years. In this review, we summarize some key technical issues related to data management in MANETs, and the studies we have done in addressing these issues, which include placement of data replicas, update management, and query processing with security management. The techniques proposed in our studies have been designed with deep considerations of MANET features including network partitioning, node participation/disappearance, limited network bandwidth, and energy efficiency. Our studies published in early 2000’s have developed a new research field as data management in MANETs. Also, our recent studies are expected to be significant guidelines of new research directions. We conclude the review by discussing some future directions for research. PMID:28496052

Data management issues in mobile ad hoc networks.

PubMed

Hara, Takahiro

2017-01-01

Research on mobile ad hoc networks (MANETs) has become a hot research topic since the middle 1990's. Over the first decade, most research focused on networking techniques, ignoring data management issues. We, however, realized early the importance of data management in MANETs, and have been conducting studies in this area for 15 years. In this review, we summarize some key technical issues related to data management in MANETs, and the studies we have done in addressing these issues, which include placement of data replicas, update management, and query processing with security management. The techniques proposed in our studies have been designed with deep considerations of MANET features including network partitioning, node participation/disappearance, limited network bandwidth, and energy efficiency. Our studies published in early 2000's have developed a new research field as data management in MANETs. Also, our recent studies are expected to be significant guidelines of new research directions. We conclude the review by discussing some future directions for research.

Office for Analysis and Evaluation of Operational Data. 1992 annual report: Nonreactors: Volume 7, No. 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-10-01

The annual report of the US Nuclear Regulatory Commission`s Office for Analysis and Evaluation of Operational Data (AEOD) is devoted to the activities performed during 1992. The report is published in two separate parts. NUREG-1272, Vol. 7, No. 1, covers power reactors and presents an overview of the operating experience of the nuclear power industry from the NRC perspective, including comments about the trends of some key performance measures. The report also includes the principal findings and issues identified in AEOD studies over the past year and summarizes information from such sources as licensee event reports, diagnostic evaluations, and reportsmore » to the NRC`s Operations Center. NUREG-1272, Vol. 7, No. 2, covers nonreactors and presents a review of the events and concerns during 1992 associated with the use of licensed material in nonreactor applications, such as personnel overexposures and medical misadministrations. Both reports also contain a discussion of the Incident Investigation Team program and summarize both the Incident Investigation Team and Augmented Inspection Team reports. Each volume contains a list of the AEOD reports issued for 1981--1992.« less

Nuclear materials 1993 annual report. Volume 8, No. 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-05-01

This annual report of the US Nuclear Regulatory Commission`s Office for Analysis and Evaluation of Operational Data (AEOD) describes activities conducted during 1993. The report is published in two parts. NUREG-1272, Vol. 8, No. 1, covers power reactors and presents an overview of the operating experience of the nuclear power industry from the NRC perspective, including comments about the trends of some key performance measures. The report also includes the principal findings and issues identified in AEOD studies over the past year and summarizes information from such sources as licensee event reports, diagnostic evaluations, and reports to the NRC`s Operationsmore » Center. NUREG-1272, Vol. 8, No. 2, covers nuclear materials and presents a review of the events and concerns during 1993 associated with the use of licensed material in nonreactor applications, such as personnel overexposures and medical misadministrations. Note that the subtitle of No. 2 has been changed from ``Nonreactors`` to ``Nuclear Materials.`` Both reports also contain a discussion of the Incident Investigation Team program and summarize both the Incident Investigation Team and Augmented Inspection Team reports. Each volume contains a list of the AEOD reports issued from 1980 through 1993.« less

A survey of simultaneous localization and mapping on unstructured lunar complex environment

NASA Astrophysics Data System (ADS)

Wang, Yiqiao; Zhang, Wei; An, Pei

2017-10-01

Simultaneous localization and mapping (SLAM) technology is the key to realizing lunar rover's intelligent perception and autonomous navigation. It embodies the autonomous ability of mobile robot, and has attracted plenty of concerns of researchers in the past thirty years. Visual sensors are meaningful to SLAM research because they can provide a wealth of information. Visual SLAM uses merely images as external information to estimate the location of the robot and construct the environment map. Nowadays, SLAM technology still has problems when applied in large-scale, unstructured and complex environment. Based on the latest technology in the field of visual SLAM, this paper investigates and summarizes the SLAM technology using in the unstructured complex environment of lunar surface. In particular, we focus on summarizing and comparing the detection and matching of features of SIFT, SURF and ORB, in the meanwhile discussing their advantages and disadvantages. We have analyzed the three main methods: SLAM Based on Extended Kalman Filter, SLAM Based on Particle Filter and SLAM Based on Graph Optimization (EKF-SLAM, PF-SLAM and Graph-based SLAM). Finally, this article summarizes and discusses the key scientific and technical difficulties in the lunar context that Visual SLAM faces. At the same time, we have explored the frontier issues such as multi-sensor fusion SLAM and multi-robot cooperative SLAM technology. We also predict and prospect the development trend of lunar rover SLAM technology, and put forward some ideas of further research.

Fats in Foods: Current Evidence for Dietary Advice.

PubMed

Nettleton, Joyce A; Brouwer, Ingeborg A; Mensink, Ronald P; Diekman, Connie; Hornstra, Gerard

2018-01-01

Current discussion of the importance of food fats in the risk of coronary heart disease (CHD) often suffers from preconceptions, misunderstandings, insufficient knowledge, and selective reasoning. As a result, the sustained controversy about dietary fat recommendations can be contradictory and confusing. To clarify some of these issues, the International Expert Movement to Improve Dietary Fat Quality in cooperation with the International Union of Nutritional Sciences (IUNS) organized a symposium at the 21st meeting of the IUNS, October 17, 2017, Buenos Aires, Argentina, to summarize the key scientific evidence underlying the controversy on the relationship between the saturated and unsaturated fat consumption and CHD risk. Presenters also discussed, using examples, the rationale for and implications of the partial replacement of foods rich in saturated fats by those rich in unsaturated fats. Presentations included strategies to fit healthier fats into meals. This report summarizes the symposium presentations. © 2018 S. Karger AG, Basel.

Convergence. Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Needham, C.; McPherson, K.

2004-03-10

We contacted 125 scientists, ethicists, legal scholars, social scientists and informal science educators to participate in a short survey designed to identify critical issues related to nanotechnology. Fifty-six (45%) responded positively, and 46 completed the survey. We then conducted a series of interviews and site visits based on scientific area, and regional representation. Key points are summarized in the attached table. Based on the results of our surveys, we were able to construct three strong areas of ethical, legal, social, and environmental issues around which to build socratic dialogs in a standard Fred Friendly Seminar format. We were also ablemore » to identify 4 science center/museum partnerships and a proposal has been submitted to NSF's NISE Program. We are preparing to submit proposals to other agencies and foundations for support.« less

Gutter oil: an overview of Chinese food safety issues and policies.

PubMed

Li, Jia; Cui, Naixue; Liu, Jianghong

2017-09-01

Food safety has become a focus of attention worldwide. In China, one of the top concerns in food safety is gutter oil, known as 'swill-cooked oil'. This Commentary summarizes the key incidents disclosed to the public by the media, and the policies regarding gutter oil at national, regional, and provincial or city levels. Several challenges the country still faces in tackling this issue are identified, including a lack of evaluation of the implementation and effect of the policies, a lack of effective technology to detect and recycle gutter oil, and the overlooking of the hazardous effect of gutter oil on health. This commentary suggests that strengthening policy implementation and evaluation, improving measurement and recycling technologies, and launching public health campaigns would help eliminate gutter oil from dining tables.

[Development and innovation of traditional Chinese medicine processing discipline and Chinese herbal pieces industry].

PubMed

Xiao, Yong-Qing; Li, Li; Liu, Ying; Ma, Yin-Lian; Yu, Ding-Rong

2016-01-01

To elucidate the key issues in the development and innovation of traditional Chinese medicine processing discipline and Chinese herbal pieces industry Chinese herbal pieces industry. According to the author's accumulated experience over years and demand of the development of the Chinese herbal pieces industry, the key issues in the development and innovation on the Chinese herbal pieces industry were summarized. According to the author, the traditional Chinese medicine processing discipline shall focus on a application basis research. The development of this discipline should be closely related to the development of Chinese herbal pieces. The traditional Chinese medicine processing discipline can be improved and its results can be transformed only if this discipline were correlated with the Chinese herbal pieces industry, matched with the development of the Chinese herbal pieces industry, and solved the problems in the development on the Chinese herbal pieces industry. The development of traditional Chinese medicine processing discipline and the Chinese herbal pieces industry also requires scientific researchers to make constant innovations, realize the specialty of the researches, and innovate based on inheritance. Copyright© by the Chinese Pharmaceutical Association.

Commentary: pediatric eHealth interventions: common challenges during development, implementation, and dissemination.

PubMed

Wu, Yelena P; Steele, Ric G; Connelly, Mark A; Palermo, Tonya M; Ritterband, Lee M

2014-07-01

To provide an overview of common challenges that pediatric eHealth researchers may encounter when planning, developing, testing, and disseminating eHealth interventions along with proposed solutions for addressing these challenges. The article draws on the existing eHealth literature and the authors' collective experience in pediatric eHealth research. The challenges associated with eHealth interventions and their proposed solutions are multifaceted and cut across a number of areas from eHealth program development through dissemination. Collaboration with a range of individuals (e.g., multidisciplinary colleagues, commercial entities, primary stakeholders) is the key to eHealth intervention success. To ensure adequate resources for design, development, and planning for sustainability, a number of public and private sources of funding are available. A study design that addresses ethical concerns and security issues is critical to ensure scientific integrity and intervention dissemination. Table I summarizes key issues to consider during eHealth intervention development, testing, and dissemination. © The Author 2014. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Advances in molecular-based diagnostics in meeting crop biosecurity and phytosanitary issues.

PubMed

Schaad, Norman W; Frederick, Reid D; Shaw, Joe; Schneider, William L; Hickson, Robert; Petrillo, Michael D; Luster, Douglas G

2003-01-01

Awareness of crop biosecurity and phytosanitation has been heightened since 9/11 and the unresolved anthrax releases in October 2001. Crops are highly vulnerable to accidental or deliberate introductions of crop pathogens from outside U.S. borders. Strategic thinking about protection against deliberate or accidental release of a plant pathogen is an urgent priority. Rapid detection will be the key to success. This review summarizes recent progress in the development of rapid real-time PCR protocols and evaluates their effectiveness in a proposed nationwide network of diagnostic laboratories that will facilitate rapid diagnostics and improved communication.

A look at statin cost-effectiveness in view of the 2013 ACC/AHA cholesterol management guidelines.

PubMed

Deaño, Roderick C; Pandya, Ankur; Jones, Erica C; Borden, William B

2014-09-01

The 2013 cholesterol management guidelines presented a major shift in recommendations on which patients at risk of cardiovascular disease should be treated and how to treat them. Implementation of the guidelines is estimated to increase substantially the number of people who would be eligible for statin therapy. As the medical community considers the broad population impact of the new cholesterol guidelines, the issue of cost-effectiveness plays a role. This review covers the basic fundamentals of cost-effectiveness analysis and summarizes the key cost-effectiveness studies that relate to the new cholesterol guidelines.

Systems and Techniques for Identifying and Avoiding Ice

NASA Technical Reports Server (NTRS)

Hansman, R. John

1995-01-01

In-flight icing is one of the most difficult aviation weather hazards facing general aviation. Because most aircraft in the general aviation category are not certified for flight into known icing conditions, techniques for identifying and avoiding in-flight ice are important to maintain safety while increasing the utility and dispatch capability which is part of the AGATE vision. This report summarizes a brief study effort which: (1) Reviewed current ice identification, forecasting, and avoidance techniques; (2) Assessed feasibility of improved forecasting and ice avoidance procedures; and (3) Identified key issues for the development of improved capability with regard to in-flight icing.

The Mayak Worker Dosimetry System (Mwds-2013): An Introduction to The Documentation

DOE PAGES

Napier, B. A.

2017-03-17

The reconstruction of radiation doses to Mayak Production Association workers in central Russia supports radiation epidemiological studies for the U.S.-Russian Joint Coordinating Committee on Radiation Effects Research. The most recent version of the dosimetry was performed with the Mayak Worker Dosimetry System-2013. Here, this introduction outlines the logic and general content of the series of articles presented in this issue of Radiation Protection Dosimetry. The articles summarize the models, describe the basis for most of the key decisions made in developing the models and present an overview of the results.

[Early-onset and late-onset male hypogonadotropic hypogonadism and osteoporosis].

PubMed

Okada, Hiroshi; Shin, Takeshi; Kobori, Yoshitomo

2016-07-01

Hypogonadism is classified into two major clinical entities, namely early-onset hypogonadism and late-onset hypogonadism. The former is characterized by the malfunction of hypothalamo-pituitary-gonadal(testicular)axis or by the primary hypofunction of testes(e.g. Klinefelter's syndrome). The latter is summarized as LOH syndrome which is attributed to the dropped level of bioavailable testosterone. In these diseases testosterone is the key molecule which may cause various symptoms relating not only to physical health but also to mental or psychologic health. In this review issues concerning bone health in these disease are described.

Evaluation of a seven state criminal history screening pilot program for long-term care workers.

PubMed

Radcliff, Tiffany A; White, Alan; West, David R; Hurd, Donna; Côté, Murray J

2013-01-01

This article summarizes results from an evaluation of a federally sponsored criminal history screening (CHS) pilot program to improve screening for workers in long-term care settings. The evaluation addressed eight key issues specified through enabling legislation, including efficiency, costs, and outcomes of screening procedures. Of the 204,339 completed screenings, 3.7% were disqualified due to criminal history, and 18.8% were withdrawn prior to completion for reasons that may include relevant criminal history. Lessons learned from the pilot program experiences may inform a new national background check demonstration program.

The Mayak Worker Dosimetry System (Mwds-2013): An Introduction to The Documentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Napier, B. A.

The reconstruction of radiation doses to Mayak Production Association workers in central Russia supports radiation epidemiological studies for the U.S.-Russian Joint Coordinating Committee on Radiation Effects Research. The most recent version of the dosimetry was performed with the Mayak Worker Dosimetry System-2013. Here, this introduction outlines the logic and general content of the series of articles presented in this issue of Radiation Protection Dosimetry. The articles summarize the models, describe the basis for most of the key decisions made in developing the models and present an overview of the results.

Update in perioperative medicine: practice changing evidence published in 2016.

PubMed

Regan, Dennis W; Kashiwagi, Deanne; Dougan, Brian; Sundsted, Karna; Mauck, Karen

2017-10-01

This summary reviews 18 key articles published in 2016 which have significant practice implications for the perioperative medical care of surgical patients. Due to the multi-disciplinary nature of the practice of perioperative medicine, important new evidence is published in journals representing a variety of medical and surgical specialties. Keeping current with the evidence that drives best practice in perioperative medicine is therefore challenging. We set out to identify, critically review, and summarize key evidence which has the most potential for practice change. We integrated the new evidence into the existing body of medical knowledge and identified practical implications for real world patient care. The articles address issues related to anticoagulation, transfusion threshold, immunosuppressive medications, postoperative delirium, myocardial injury after noncardiac surgery, postoperative pain management, perioperative management of antihypertensives, perioperative fasting, and perioperative diabetic control.

Orbital transfer vehicle concept definition and system analysis study, 1986. Volume 9: Study extension results

NASA Technical Reports Server (NTRS)

Kofal, Allen E.

1987-01-01

The purpose of this extension to the OTV Concept Definition and Systems Analysis Study was to improve the definition of the OTV Program that will be most beneficial to the nation in the 1995 to 2010 timeframe. The implications of the defined mission and defined launch vehicle are investigated. The key mission requirements identified for the Space Transportation Architecture Study (STAS) were established and reflect a need for early capability and more ambitious capability growth. The key technical objectives and related issues addressed are summarized. The analyses of selected areas including aerobrake design, proximity operations, and the balance of EVA and IVA operations used in the support of the OTV at the space-base were enhanced. Sensitivity studies were conducted to establish how the OTV program should be tailored to meet changing circumstances.

Resilience and challenges of marine social-ecological systems under complex and interconnected drivers.

PubMed

Villasante, Sebastián; Macho, Gonzalo; Antelo, Manel; Rodríguez-González, David; Kaiser, Michel J

2013-12-01

In this paper, we summarize the contributions made by an interdisciplinary group of researchers from different disciplines (biology, ecology, economics, and law) that deal with key dimensions of marine social-ecological systems. Particularly, the local and global seafood provision; the feasibility and management of marine protected areas; the use of marine ecosystem services; the institutional dimension in European fisheries, and the affordable models for providing scientific advice to small-scale fisheries. This Special Issue presents key findings from selected case studies around the world available to educators, policy makers, and the technical community. Together, these papers show that a range of diverse ecological, economic, social, and institutional components often mutually interact at spatial and temporal scales, which evidence that managing marine social-ecological systems needs a continuous adaptability to navigate into new governance systems.

[Controversies around QALYs].

PubMed

Rogalewicz, Vladimír; Barták, Miroslav

The paper summarizes the criticisms of the QALY concept utilization in health-economic evaluations that has been growing stronger in the last years. Despite of its limitations, the QALY concept has been routinely used in many countries incl. the Czech Republic. However, some states disapproved QALYs as an optimizing criterion at the level of their political decisions. The critical reflection concerns both the theoretical and the experimental issues. Based on a literary review, fundamental arguments against the concept are summarized, and a synthesis of material objections is presented. The critical arguments focus on the foundations of the QALY concept in the economic theory, some ethical principles, inconsistencies and technical imperfections of the quality-of-life measurement tools used in QALY calculations, the substitution rule, differences between various diagnoses, and disregarding some other important parameters. As a whole, the critics´ arguments can be judged as quite strong. The future will show whether the critical arguments summarized in this paper will lead to a development of alternative tools that have a potential of eliminating imperfections in QALYs, and consequently provide more complex data for the decision process.Key words: cost-effectiveness - health technology assessment - HTA - QALY - utility measure for medical interventions.

Toward Impactful Collaborations on Computing and Mental Health.

PubMed

Calvo, Rafael Alejandro; Dinakar, Karthik; Picard, Rosalind; Christensen, Helen; Torous, John

2018-02-09

We describe an initiative to bring mental health researchers, computer scientists, human-computer interaction researchers, and other communities together to address the challenges of the global mental ill health epidemic. Two face-to-face events and one special issue of the Journal of Medical Internet Research were organized. The works presented in these events and publication reflect key state-of-the-art research in this interdisciplinary collaboration. We summarize the special issue articles and contextualize them to present a picture of the most recent research. In addition, we describe a series of collaborative activities held during the second symposium and where the community identified 5 challenges and their possible solutions. ©Rafael Alejandro Calvo, Karthik Dinakar, Rosalind Picard, Helen Christensen, John Torous. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 09.02.2018.

Materials for lithium-ion battery safety.

PubMed

Liu, Kai; Liu, Yayuan; Lin, Dingchang; Pei, Allen; Cui, Yi

2018-06-01

Lithium-ion batteries (LIBs) are considered to be one of the most important energy storage technologies. As the energy density of batteries increases, battery safety becomes even more critical if the energy is released unintentionally. Accidents related to fires and explosions of LIBs occur frequently worldwide. Some have caused serious threats to human life and health and have led to numerous product recalls by manufacturers. These incidents are reminders that safety is a prerequisite for batteries, and serious issues need to be resolved before the future application of high-energy battery systems. This Review aims to summarize the fundamentals of the origins of LIB safety issues and highlight recent key progress in materials design to improve LIB safety. We anticipate that this Review will inspire further improvement in battery safety, especially for emerging LIBs with high-energy density.

Materials for lithium-ion battery safety

PubMed Central

Liu, Kai

2018-01-01

Lithium-ion batteries (LIBs) are considered to be one of the most important energy storage technologies. As the energy density of batteries increases, battery safety becomes even more critical if the energy is released unintentionally. Accidents related to fires and explosions of LIBs occur frequently worldwide. Some have caused serious threats to human life and health and have led to numerous product recalls by manufacturers. These incidents are reminders that safety is a prerequisite for batteries, and serious issues need to be resolved before the future application of high-energy battery systems. This Review aims to summarize the fundamentals of the origins of LIB safety issues and highlight recent key progress in materials design to improve LIB safety. We anticipate that this Review will inspire further improvement in battery safety, especially for emerging LIBs with high-energy density. PMID:29942858

Issues in stinging insect allergy immunotherapy: a review.

PubMed

Finegold, Ira

2008-08-01

The treatment of insect allergy by desensitization still continues to present with some unanswered questions. This review will focus mainly on articles that have dealt with these issues in the past 2 years. With the publication in 2007 of Allergen Immunotherapy: a practice parameter second update, many of the key issues were reviewed and summarized. Other recent studies deal with omalizumab pretreatment of patients with systemic mastocytosis and very severe allergic reactions to immunotherapy. It would appear that venom immunotherapy is somewhat unique compared to inhalant allergen immunotherapy in that premedication prior to rush protocols may not be necessary and that intervals of therapy may be longer than with allergen immunotherapy. The use of concomitant medications such as beta-blockers may be indicated in special situations. Angiotensin-converting enzyme inhibitors can be stopped temporarily before venom injections to prevent reactions. The issue of when to discontinue immunotherapy remains unsettled and should be individualized to patient requirements. The newest revision of the Immunotherapy Parameters provides much needed information concerning successful treatment with immunotherapy of Hymenoptera-sensitive patients.

The Evaluation and Office Management of Hemorrhoids for the Gastroenterologist.

PubMed

Guttenplan, Mitchel

2017-07-01

Hemorrhoid disease is extremely common, and seldom requires surgical intervention. The vast majority of patients can be cared for in the office setting and by the gastroenterologist. This piece aims to summarize the epidemiology and pathophysiology of hemorrhoid disease, along with the proper evaluation and office-based treatment of these patients. Most GI fellowship training programs spend little time on these topics, and the recommendation has been made to include anorectal care in the GI's "core curriculum." The use of the anoscope and a proper anorectal examination are keys to evaluating these patients, and the techniques available to treat these patients are described. Often overlooked in these patients are other anorectal issues that occur alongside hemorrhoidal issues very commonly-the most common being anal fissure. Comprehensive management of all of these issues will allow all but the most severely affected patients to avoid the expense and morbidity of surgical intervention. The anatomy, etiology, pathophysiology, diagnosis, and non-surgical treatment of hemorrhoid disease are presented with the gastroenterologist in mind.

A Survey on Energy Conserving Mechanisms for the Internet of Things: Wireless Networking Aspects.

PubMed

Abbas, Zeeshan; Yoon, Wonyong

2015-09-25

The Internet of Things (IoT) is an emerging key technology for future industries and everyday lives of people, where a myriad of battery operated sensors, actuators, and smart objects are connected to the Internet to provide services such as mobile healthcare, intelligent transport system, environmental monitoring, etc. Since energy efficiency is of utmost importance to these battery constrained IoT devices, IoT-related standards and research works have focused on the device energy conserving issues. This paper presents a comprehensive survey on energy conserving issues and solutions in using diverse wireless radio access technologies for IoT connectivity, e.g., the 3rd Generation Partnership Project (3GPP) machine type communications, IEEE 802.11ah, Bluetooth Low Energy (BLE), and Z-Wave. We look into the literature in broad areas of standardization, academic research, and industry development, and structurally summarize the energy conserving solutions based on several technical criteria. We also propose future research directions regarding energy conserving issues in wireless networking-based IoT.

Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation.

PubMed

Cavero, Icilio; Guillon, Jean-Michel; Ballet, Veronique; Clements, Mike; Gerbeau, Jean-Frédéric; Holzgrefe, Henry

2016-01-01

The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a nonclinical Safety Pharmacology paradigm for discovering electrophysiological mechanisms that are likely to confer proarrhythmic liability to drug candidates intended for human use. Key talks delivered at the 'CiPA on my mind' session, held during the 2015 Annual Meeting of the Safety Pharmacology Society (SPS), are summarized. Issues and potential solutions relating to crucial constituents [e.g., biological materials (ion channels and pluripotent stem cell-derived cardiomyocytes), study platforms, drug solutions, and data analysis] of CiPA core assays are critically examined. In order to advance the CiPA paradigm from the current testing and validation stages to a research and regulatory drug development strategy, systematic guidance by CiPA stakeholders is necessary to expedite solutions to pending and newly arising issues. Once a study protocol is proved to yield robust and reproducible results within and across laboratories, it can be implemented as qualified regulatory procedure. Copyright © 2016 Elsevier Inc. All rights reserved.

A Survey on Energy Conserving Mechanisms for the Internet of Things: Wireless Networking Aspects

PubMed Central

Abbas, Zeeshan; Yoon, Wonyong

2015-01-01

The Internet of Things (IoT) is an emerging key technology for future industries and everyday lives of people, where a myriad of battery operated sensors, actuators, and smart objects are connected to the Internet to provide services such as mobile healthcare, intelligent transport system, environmental monitoring, etc. Since energy efficiency is of utmost importance to these battery constrained IoT devices, IoT-related standards and research works have focused on the device energy conserving issues. This paper presents a comprehensive survey on energy conserving issues and solutions in using diverse wireless radio access technologies for IoT connectivity, e.g., the 3rd Generation Partnership Project (3GPP) machine type communications, IEEE 802.11ah, Bluetooth Low Energy (BLE), and Z-Wave. We look into the literature in broad areas of standardization, academic research, and industry development, and structurally summarize the energy conserving solutions based on several technical criteria. We also propose future research directions regarding energy conserving issues in wireless networking-based IoT. PMID:26404275

Neurodegenerative diseases in the era of targeted therapeutics: how to handle a tangled issue.

PubMed

Tofaris, George K; Schapira, Anthony H V

2015-05-01

Neurodegenerative diseases are age-related and relentlessly progressive with increasing prevalence and no cure or lasting symptomatic therapy. The well-recognized prodromal phase in many forms of neurodegeneration suggests a prolonged period of neuronal compensated dysfunction prior to cell loss that may be amenable to therapeutic intervention. Although most efforts to date have been focused on misfolded toxic proteins, it is now clear that widespread changes in protein homeostasis occur early in these diseases and understanding this fundamental biology is key to the design of targeted therapies. What has emerged from molecular genetics and animal studies is a previously less appreciated association of neurodegenerative diseases with defects in the molecular regulation of protein trafficking between cellular organelles, especially the intricate network of endosomes, lysosomes, autophagosomes and mitochondria. Here we summarized the broader concepts that stemmed from this Special Issue on "Protein Clearance in Neurodegenerative diseases: from mechanisms to therapies". This article is part of a Special Issue entitled 'Neuronal Protein'. Copyright © 2015 Elsevier Inc. All rights reserved.

Marine Environmental Emergencies in the North Pacific Ocean: Lessons Learned from Recent Oil Spills.

PubMed

Yim, Un Hyuk; Short, Jeffrey

2017-07-01

Increasing marine vessel traffic, and oil and gas exploration and development throughout the North Pacific basin brings increasing risks of oil spills. Recognizing the serious challenges presented to response authorities, this Special Issue was organized by the North Pacific Marine Science Organization to provide an introduction to the current state of scientific understanding regarding the environmental effects of oil spills. Because interactions of spilled oils with biota and their habitats are complex, the most serious environmental damages from these spills are not necessarily those of greatest immediate concern by the public. Our overarching goal for this Special Issue is to provide an efficient introduction to the most important ways that oil spills can harm biota, habitats, and ecosystems through invited, targeted mini-reviews augmented by original research articles. We provide a brief background on the challenges posed by large oil spills to response authorities, summarize findings from the articles published in this Special Issue, and highlight some key research needs.

Office for Analysis and Evaluation of Operational Data 1994-FY 95 annual report. Volume 9, Number 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This annual report of the US Nuclear Regulatory Commission`s Office for Analysis and Evaluation of Operational Data (AEOD) describes activities conducted during CY 1994 and FY 1995. The report is published in three parts. NUREG-1272, Vol. 9, No. 1, covers power reactors and presents an overview of the operating experience of the nuclear power industry from the NRC perspective, including comments about the trends of some key performance measures. The report also includes the principal findings and issues identified in AEOD studies over the past year and summarizes information from such sources as licensee event reports, diagnostic evaluations, and reportsmore » to the NRC`s Operations Center. NUREG-1272, Vol. 9, No. 2, covers nuclear materials and presents a review of the events and concerns associated with the use of licensed material in nonreactor applications, such as personnel overexposures and medical misadministrations. Both reports also contain a discussion of the Incident Investigation Team program and summarize both the Incident Investigation Team and Augmented Inspection Team reports. Each volume contains a list of the AEOD reports issued from 1980 through FY 1995. NUREG-1272, Vol. 9, No. 3, covers technical training and presents the activities of the Technical Training Center in support of the NRC`s mission.« less

Office for Analysis and Evaluation of Operational Data 1996 annual report. Volume 10, Number 1: Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-12-01

This annual report of the US Nuclear Regulatory Commission`s Office for Analysis and Evaluation of Operational Data (AEOD) describes activities conducted during 1996. The report is published in three parts. NUREG-1272, Vol. 10, No. 1, covers power reactors and presents an overview of the operating experience of the nuclear power industry from the NRC perspective, including comments about trends of some key performance measures. The report also includes the principal findings and issues identified in AEOD studies over the past year and summarizes information from such sources as licensee event reports and reports to the NRC`s Operations Center. NUREG-1272, Vol.more » 10, No. 2, covers nuclear materials and presents a review of the events and concerns during 1996 associated with the use of licensed material in nonreactor applications, such as personnel overexposures and medical misadministrations. Both reports also contain a discussion of the Incident Investigation Team program and summarize both the Incident Investigation Team and Augmented Inspection Team reports. Each volume contains a list of the AEOD reports issued from CY 1980 through 1996. NUREG-1272, Vol. 10, No. 3, covers technical training and presents the activities of the Technical Training Center in support of the NRC`s mission in 1996.« less

Understanding and Improving the Health of People Who Experience Incarceration: An Overview and Synthesis.

PubMed

Kinner, Stuart A; Young, Jesse T

2018-06-01

The world prison population is growing at a rate that exceeds the rate of population growth. This issue of Epidemiologic Reviews comprises articles in which researchers summarize what is known about some of the key health issues facing people in prison, particularly in relation to human immunodeficiency virus and other blood-borne viral infections. A key recurring theme is that addressing the health needs of people in prison is important to reducing health inequalities at the population level-that prisoner health is public health. The reviews also highlight some critical evidence gaps, notably the lack of evidence from low- and middle-income countries, and the limited number of longitudinal studies in which health behaviors, health outcomes, or health service experiences after release from prison are documented. Despite growing evidence of the poor health of detained adolescents, none of the included reviews considered this population. Further research on the health of young people who cycle through juvenile detention should be a priority. Despite a rapidly growing literature on the health of people who experience incarceration, some critical health issues remain poorly understood, and there has been insufficient attention devoted to co-occurring health conditions and the consequent need for coordinated care. Key populations in custodial settings remain understudied, limiting capacity to develop targeted, evidence-based responses to their health needs. The quality of many studies is suboptimal, and although rigorous, independent research in correctional settings can be challenging, it is not impossible and is critical to laying the groundwork for evidence-based reform.

Persufflation (or gaseous oxygen perfusion) as a method of organ preservation.

PubMed

Suszynski, Thomas M; Rizzari, Michael D; Scott, William E; Tempelman, Linda A; Taylor, Michael J; Papas, Klearchos K

2012-06-01

Improved preservation techniques have the potential to improve transplant outcomes by better maintaining donor organ quality and by making more organs available for allotransplantation. Persufflation, (PSF, gaseous oxygen perfusion) is potentially one such technique that has been studied for over a century in a variety of tissues, but has yet to gain wide acceptance for a number of reasons. A principal barrier is the perception that ex vivo PSF will cause in vivo embolization post-transplant. This review summarizes the extensive published work on heart, liver, kidney, small intestine and pancreas PSF, discusses the differences between anterograde and retrograde PSF, and between PSF and other conventional methods of organ preservation (static cold storage, hypothermic machine perfusion). Prospective implications of PSF within the broader field of organ transplantation, and in the specific application with pancreatic islet isolation and transplant are also discussed. Finally, key issues that need to be addressed before PSF becomes a more widely utilized preservation strategy are summarized and discussed. Copyright © 2012 Elsevier Inc. All rights reserved.

Persufflation (or Gaseous Oxygen Perfusion) as a Method of Organ Preservation

PubMed Central

Suszynski, Thomas M.; Rizzari, Michael D.; Scott, William E.; Tempelman, Linda A.; Taylor, Michael J.; Papas, Klearchos K.

2012-01-01

Improved preservation techniques have the potential to improve transplant outcomes by better maintaining donor organ quality and by making more organs available for allotransplantation. Persufflation, (PSF, gaseous oxygen perfusion) is potentially one such technique that has been studied for over a century in a variety of tissues, but has yet to gain wide acceptance for a number of reasons. A principal barrier is the perception that ex vivo PSF will cause in vivo embolization post-transplant. This review summarizes the extensive published work on heart, liver, kidney, small intestine and pancreas PSF, discusses the differences between anterograde and retrograde PSF and between PSF and other conventional methods of organ preservation (static cold storage, hypothermic machine perfusion). Prospective implications of PSF within the broader field of organ transplantation, and in the specific application with pancreatic islet isolation and transplant are also discussed. Finally, key issues that need to be addressed before PSF becomes a more widely utilized preservation strategy are summarized and discussed. PMID:22301419

Analysis about modeling MEC7000 excitation system of nuclear power unit

NASA Astrophysics Data System (ADS)

Liu, Guangshi; Sun, Zhiyuan; Dou, Qian; Liu, Mosi; Zhang, Yihui; Wang, Xiaoming

2018-02-01

Aiming at the importance of accurate modeling excitation system in stability calculation of nuclear power plant inland and lack of research in modeling MEC7000 excitation system,this paper summarize a general method to modeling and simulate MEC7000 excitation system. Among this method also solve the key issues of computing method of IO interface parameter and the conversion process of excitation system measured model to BPA simulation model. At last complete the simulation modeling of MEC7000 excitation system first time in domestic. By used No-load small disturbance check, demonstrates that the proposed model and algorithm is corrective and efficient.

Decomposability and scalability in space-based observatory scheduling

NASA Technical Reports Server (NTRS)

Muscettola, Nicola; Smith, Stephen F.

1992-01-01

In this paper, we discuss issues of problem and model decomposition within the HSTS scheduling framework. HSTS was developed and originally applied in the context of the Hubble Space Telescope (HST) scheduling problem, motivated by the limitations of the current solution and, more generally, the insufficiency of classical planning and scheduling approaches in this problem context. We first summarize the salient architectural characteristics of HSTS and their relationship to previous scheduling and AI planning research. Then, we describe some key problem decomposition techniques supported by HSTS and underlying our integrated planning and scheduling approach, and we discuss the leverage they provide in solving space-based observatory scheduling problems.

Medication Adherence: A Call for Action

PubMed Central

Bosworth, Hayden B.; Granger, Bradi B.; Mendys, Phil; Brindis, Ralph; Burkholder, Rebecca; Czajkowski, Susan M.; Daniel, Jodi G.; Ekman, Inger; Ho, Michael; Johnson, Mimi; Kimmel, Stephen E.; Liu, Larry Z; Musaus, John; Shrank, William H.; Buono, Elizabeth Whalley; Weiss, Karen; Granger, Christopher B.

2013-01-01

Poor adherence to efficacious cardiovascular related medications has led to considerable morbidity, mortality, and avoidable health care costs. This paper provides results of a recent think tank meeting in which various stakeholder groups representing key experts from consumers, community health providers, the academic community, decision-making government officials (FDA, NIH, etc), and industry scientists met to evaluate the current status of medication adherence and provide recommendations for improving outcomes. Below, we review the magnitude of the problem of medication adherence, prevalence, impact, and cost. We then summarize proven effective approaches and conclude with a discussion of recommendations to address this growing and significant public health issue of medication non adherence. PMID:21884856

Perovskite Solar Cells and Devices at EPFL Valais Wallis.

PubMed

Nazeeruddin, Mohammad Khaja

2016-09-22

Stability required! Perovskite solar cells have emerged as one of the most exciting fields of research, owing to their impressive rise in power conversion efficiency surpassing 22% in six short years of research. Current research is focused on ways to improve stability of perovskite-based devices, a key characteristic required to bring this technology from the lab into the market. In this Editorial, guest editor Prof. Mohammad Khaja Nazeeruddin describes the context of this Special Issue, and summarizes the work being performed in his research group toward this low-cost near-future photovoltaic technology. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Target Fabrication Technology and New Functional Materials for Laser Fusion and Laser-Plasma Experiment

NASA Astrophysics Data System (ADS)

Nagai, Keiji; Norimatsu, Takayoshi; Izawa, Yasukazu

Target fabrication technique is a key issue of laser fusion. We present a comprehensive, up-to-data compilation of laser fusion target fabrication and relating new materials. To achieve highly efficient laser implosion, organic and inorganic highly spherical millimeter-sized capsules and cryogenic hydrogen layers inside should be uniform in diameter and thickness within sub-micrometer ˜ nanometer error. Porous structured targets and molecular cluster targets are required for laser-plasma experiments and applications. Various technologies and new materials concerning above purposes are summarized including fast-ignition targets, equation-of-state measurement targets, high energy ion generation targets, etc.

Solid-State Lighting: Early Lessons Learned on the Way to Market

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sandahl, Linda J.; Cort, Katherine A.; Gordon, Kelly L.

2013-12-31

The purpose of this report is to document early challenges and lessons learned in the solid-state lighting (SSL) market development as part of the DOE’s SSL Program efforts to continually evaluate market progress in this area. This report summarizes early actions taken by DOE and others to avoid potential problems anticipated based on lessons learned from the market introduction of compact fluorescent lamps and identifies issues, challenges, and new lessons that have been learned in the early stages of the SSL market introduction. This study identifies and characterizes12 key lessons that have been distilled from DOE SSL program results.

Of taps and toilets: quasi-experimental protocol for evaluating community-demand-driven projects.

PubMed

Pattanayak, Subhrendu K; Poulos, Christine; Yang, Jui-Chen; Patil, Sumeet R; Wendland, Kelly J

2009-09-01

Sustainable and equitable access to safe water and adequate sanitation are widely acknowledged as vital, yet neglected, development goals. Water supply and sanitation (WSS) policies are justified because of the usual efficiency criteria, but also major equity concerns. Yet, to date there are few scientific impact evaluations showing that WSS policies are effective in delivering social welfare outcomes. This lack of an evaluation culture is partly because WSS policies are characterized by diverse mechanisms, broad goals and the increasing importance of decentralized delivery, and partly because programme administrators are unaware of appropriate methods. We describe a protocol for a quasi-experimental evaluation of a community-demand-driven programme for water and sanitation in rural India, which addresses several evaluation challenges. After briefly reviewing policy and implementation issues in the sector, we describe key features of our protocol, including control group identification, pre-post measurement, programme theory, sample sufficiency and robust indicators. At its core, our protocol proposes to combine propensity score matching and difference-in-difference estimation. We conclude by briefly summarizing how quasi-experimental impact evaluations can address key issues in WSS policy design and when such evaluations are needed.

Ethical practice in Telehealth and Telemedicine.

PubMed

Chaet, Danielle; Clearfield, Ron; Sabin, James E; Skimming, Kathryn

2017-10-01

This article summarizes the report of the American Medical Association's (AMA) Council on Ethical and Judicial Affairs (CEJA) on ethical practice in telehealth and telemedicine. Through its reports and recommendations, CEJA is responsible for maintaining and updating the AMA Code of Medical Ethics (Code). CEJA reports are developed through an iterative process of deliberation with input from multiple stakeholders; report recommendations, once adopted by the AMA House of Delegates, become ethics policy of the AMA and are issued as Opinions in the Code. To provide enduring guidance for the medical profession as a whole, CEJA strives to articulate expectations for conduct that are as independent of specific technologies or models of practice as possible. The present report, developed at the request of the House of Delegates, provides broad guidance for ethical conduct relating to key issues in telehealth/telemedicine. The report and recommendations were debated at meetings of the House in June and November 2015; recommendations were adopted in June 2016 and published as Opinion E-1.2.12, Ethical Practice in Telemedicine, in November 2016. A summary of the key points of the recommendations can be found in Appendix A (online), and the full text of the opinion can be found in Appendix B (online).

Overview of the Special Issue: A Multi-Model Framework to ...

EPA Pesticide Factsheets

The Climate Change Impacts and Risk Analysis (CIRA) project establishes a new multi-model framework to systematically assess the impacts, economic damages, and risks from climate change in the United States. The primary goal of this framework to estimate how climate change impacts and damages in the United States are avoided or reduced due to global greenhouse gas (GHG) emissions mitigation scenarios. Scenarios are designed to explore key uncertainties around the measurement of these changes. The modeling exercise presented in this Special Issue includes two integrated assessment models and 15 sectoral models encompassing six broad impacts sectors - water resources, electric power, infrastructure, human health, ecosystems, and forests. Three consistent emissions scenarios are used to analyze the benefits of global GHG mitigation targets: a reference and two policy scenarios, with total radiative forcing in 2100 of 10.0W/m2, 4.5W/m2, and 3.7W/m2. A range of climate sensitivities, climate models, natural variability measures, and structural uncertainties of sectoral models are examined to explore the implications of key uncertainties. This overview paper describes the motivations, goals, design, and academic contribution of the CIRA modeling exercise and briefly summarizes the subsequent papers in this Special Issue. A summary of results across impact sectors is provided showing that: GHG mitigation provides benefits to the United States that increase over

Large-Eddy Simulation: Current Capabilities, Recommended Practices, and Future Research

NASA Technical Reports Server (NTRS)

Georgiadis, Nicholas J.; Rizzetta, Donald P.; Fureby, Christer

2009-01-01

This paper presents the results of an activity by the Large Eddy Simulation (LES) Working Group of the AIAA Fluid Dynamics Technical Committee to (1) address the current capabilities of LES, (2) outline recommended practices and key considerations for using LES, and (3) identify future research needs to advance the capabilities and reliability of LES for analysis of turbulent flows. To address the current capabilities and future needs, a survey comprised of eleven questions was posed to LES Working Group members to assemble a broad range of perspectives on important topics related to LES. The responses to these survey questions are summarized with the intent not to be a comprehensive dictate on LES, but rather the perspective of one group on some important issues. A list of recommended practices is also provided, which does not treat all aspects of a LES, but provides guidance on some of the key areas that should be considered.

A legacy of struggle: the OSHA ergonomics standard and beyond, Part II.

PubMed

Delp, Linda; Mojtahedi, Zahra; Sheikh, Hina; Lemus, Jackie

2014-11-01

The OSHA ergonomics standard issued in 2000 was repealed within four months through a Congressional resolution that limits future ergonomics rulemaking. This section continues the conversation initiated in Part I, documenting a legacy of struggle for an ergonomics standard through the voices of eight labor, academic, and government key informants. Part I summarized important components of the standard; described the convergence of labor activism, research, and government action that laid the foundation for a standard; and highlighted the debates that characterized the rulemaking process. Part II explores the anti-regulatory political landscape of the 1990s, as well as the key opponents, power dynamics, and legal maneuvers that led to repeal of the standard. This section also describes the impact of the ergonomics struggle beyond the standard itself and ends with a discussion of creative state-level policy initiatives and coalition approaches to prevent work-related musculoskeletal disorders (WMSDs) in today's sociopolitical context.

Caffeine: Friend or Foe?

PubMed

Doepker, Candace; Lieberman, Harris R; Smith, Andrew Paul; Peck, Jennifer D; El-Sohemy, Ahmed; Welsh, Brian T

2016-01-01

The debate on the safety of and regulatory approaches for caffeine continues among various stakeholders and regulatory authorities. This decision-making process comes with significant challenges, particularly when considering the complexities of the available scientific data, making the formulation of clear science-based regulatory guidance more difficult. To allow for discussions of a number of key issues, the North American Branch of the International Life Sciences Institute (ILSI) convened a panel of subject matter experts for a caffeine-focused session entitled "Caffeine: Friend or Foe?," which was held during the 2015 ILSI Annual Meeting. The panelists' expertise covered topics ranging from the natural occurrence of caffeine in plants and interindividual metabolism of caffeine in humans to specific behavioral, reproductive, and cardiovascular effects related to caffeine consumption. Each presentation highlighted the potential risks, benefits, and challenges that inform whether caffeine exposure warrants concern. This paper aims to summarize the key topics discussed during the session.

Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis

PubMed Central

Nieto-Torres, Jose L.; Verdiá-Báguena, Carmina; Castaño-Rodriguez, Carlos; Aguilella, Vicente M.; Enjuanes, Luis

2015-01-01

Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming ion conductive pores. In general, these channels display mild ion selectivity, and, eventually, membrane lipids play key structural and functional roles in the pore. Viroporins stimulate virus production through different mechanisms, and ion channel conductivity has been proved particularly relevant in several cases. Key stages of the viral cycle such as virus uncoating, transport and maturation are ion-influenced processes in many viral species. Besides boosting virus propagation, viroporins have also been associated with pathogenesis. Linking pathogenesis either to the ion conductivity or to other functions of viroporins has been elusive for a long time. This article summarizes novel pathways leading to disease stimulated by viroporin ion conduction, such as inflammasome driven immunopathology. PMID:26151305

Enhancing End-to-End Performance of Information Services Over Ka-Band Global Satellite Networks

NASA Technical Reports Server (NTRS)

Bhasin, Kul B.; Glover, Daniel R.; Ivancic, William D.; vonDeak, Thomas C.

1997-01-01

The Internet has been growing at a rapid rate as the key medium to provide information services such as e-mail, WWW and multimedia etc., however its global reach is limited. Ka-band communication satellite networks are being developed to increase the accessibility of information services via the Internet at global scale. There is need to assess satellite networks in their ability to provide these services and interconnect seamlessly with existing and proposed terrestrial telecommunication networks. In this paper the significant issues and requirements in providing end-to-end high performance for the delivery of information services over satellite networks based on various layers in the OSI reference model are identified. Key experiments have been performed to evaluate the performance of digital video and Internet over satellite-like testbeds. The results of the early developments in ATM and TCP protocols over satellite networks are summarized.

Mammals of South America, Volume 1, Marsupials, Xenarthrans, Shrews, and Bats

USGS Publications Warehouse

Gardner, A.L.

2007-01-01

The vast terrain between Panama and Tierra del Fuego contains some of the world?s richest mammalian fauna, but until now it has lacked a comprehensive systematic reference to the identification, distribution, and taxonomy of its mammals. The first such book of its kind and the inaugural volume in a three-part series, Mammals of South America both summarizes existing information and encourages further research of the mammals indigenous to the region. Containing identification keys and brief descriptions of each order, family, and genus, the first volume of Mammals of South America covers marsupials, shrews, armadillos, sloths, anteaters, and bats. Species accounts include taxonomic descriptions, synonymies, keys to identification, distributions with maps and a gazetteer of marginal localities, lists of recognized subspecies, brief summaries of natural history information, and discussions of issues related to taxonomic interpretations. Highly anticipated and much needed, this book will be a landmark contribution to mammalogy, zoology, tropical biology, and conservation biology.

[Landscape classification: research progress and development trend].

PubMed

Liang, Fa-Chao; Liu, Li-Ming

2011-06-01

Landscape classification is the basis of the researches on landscape structure, process, and function, and also, the prerequisite for landscape evaluation, planning, protection, and management, directly affecting the precision and practicability of landscape research. This paper reviewed the research progress on the landscape classification system, theory, and methodology, and summarized the key problems and deficiencies of current researches. Some major landscape classification systems, e. g. , LANMAP and MUFIC, were introduced and discussed. It was suggested that a qualitative and quantitative comprehensive classification based on the ideology of functional structure shape and on the integral consideration of landscape classification utility, landscape function, landscape structure, physiogeographical factors, and human disturbance intensity should be the major research directions in the future. The integration of mapping, 3S technology, quantitative mathematics modeling, computer artificial intelligence, and professional knowledge to enhance the precision of landscape classification would be the key issues and the development trend in the researches of landscape classification.

Comprehensive genomic studies: emerging regulatory, strategic, and quality assurance challenges for biorepositories.

PubMed

McDonald, Sandra A; Mardis, Elaine R; Ota, David; Watson, Mark A; Pfeifer, John D; Green, Jonathan M

2012-07-01

As part of the molecular revolution sweeping medicine, comprehensive genomic studies are adding powerful dimensions to medical research. However, their power exposes new regulatory, strategic, and quality assurance challenges for biorepositories. A key issue is that unlike other research techniques commonly applied to banked specimens, nucleic acid sequencing, if sufficiently extensive, yields data that could identify a patient. This evolving paradigm renders the concepts of anonymized and anonymous specimens increasingly outdated. The challenges for biorepositories in this new era include refined consent processes and wording, selection and use of legacy specimens, quality assurance procedures, institutional documentation, data sharing, and interaction with institutional review boards. Given current trends, biorepositories should consider these issues now, even if they are not currently experiencing sample requests for genomic analysis. We summarize our current experiences and best practices at Washington University Medical School, St Louis, MO, our perceptions of emerging trends, and recommendations.

Modulated Raman Spectroscopy for Enhanced Cancer Diagnosis at the Cellular Level

PubMed Central

De Luca, Anna Chiara; Dholakia, Kishan; Mazilu, Michael

2015-01-01

Raman spectroscopy is emerging as a promising and novel biophotonics tool for non-invasive, real-time diagnosis of tissue and cell abnormalities. However, the presence of a strong fluorescence background is a key issue that can detract from the use of Raman spectroscopy in routine clinical care. The review summarizes the state-of-the-art methods to remove the fluorescence background and explores recent achievements to address this issue obtained with modulated Raman spectroscopy. This innovative approach can be used to extract the Raman spectral component from the fluorescence background and improve the quality of the Raman signal. We describe the potential of modulated Raman spectroscopy as a rapid, inexpensive and accurate clinical tool to detect the presence of bladder cancer cells. Finally, in a broader context, we show how this approach can greatly enhance the sensitivity of integrated Raman spectroscopy and microfluidic systems, opening new prospects for portable higher throughput Raman cell sorting. PMID:26110401

Quantitative modeling of coupled piezo-elastodynamic behavior of piezoelectric actuators bonded to an elastic medium for structural health monitoring: a review.

PubMed

Huang, Guoliang; Song, Fei; Wang, Xiaodong

2010-01-01

Elastic waves, especially guided waves, generated by a piezoelectric actuator/sensor network, have shown great potential for on-line health monitoring of advanced aerospace, nuclear, and automotive structures in recent decades. Piezoelectric materials can function as both actuators and sensors in these applications due to wide bandwidth, quick response and low costs. One of the most fundamental issues surrounding the effective use of piezoelectric actuators is the quantitative evaluation of the resulting elastic wave propagation by considering the coupled piezo-elastodynamic behavior between the actuator and the host medium. Accurate characterization of the local interfacial stress distribution between the actuator and the host medium is the key issue for the problem. This paper presents a review of the development of analytical, numerical and hybrid approaches for modeling of the coupled piezo-elastodynamic behavior. The resulting elastic wave propagation for structural health monitoring is also summarized.

Comprehensive Genomic Studies: Emerging Regulatory, Strategic, and Quality Assurance Challenges for Biorepositories

PubMed Central

McDonald, Sandra A.; Mardis, Elaine R.; Ota, David; Watson, Mark A.; Pfeifer, John D.; Green, Jonathan M.

2012-01-01

As part of the molecular revolution sweeping medicine, comprehensive genomic studies are adding powerful dimensions to medical research. However, their power exposes new regulatory, strategic, and quality assurance challenges for biorepositories. A key issue is that unlike other research techniques commonly applied to banked specimens, nucleic acid sequencing, if sufficiently extensive, yields data that could identify a patient. This evolving paradigm renders the concepts of anonymized and anonymous specimens increasingly outdated. The challenges for biorepositories in this new era include refined consent processes and wording, selection and use of legacy specimens, quality assurance procedures, institutional documentation, data sharing, and interaction with institutional review boards. Given current trends, biorepositories should consider these issues now, even if they are not currently experiencing sample requests for genomic analysis. We summarize our current experiences and best practices at Washington University Medical School, St Louis, MO, our perceptions of emerging trends, and recommendations. PMID:22706855

Assessing the need for a new nationally representative household panel survey in the United States

PubMed Central

Moffitt, Robert; Schoeni, Robert F.; Brown, Charles; Chase-Lansdale, P. Lindsay; Couper, Mick P.; Diez-Roux, Ana V.; Hurst, Erik; Seltzer, Judith A.

2015-01-01

We introduce this special issue on the critical matter of whether the existing household panel surveys in the U.S. are adequate to address the important emerging social science and policy questions of the next few decades. We summarize the conference papers which address this issue in different domains. The papers detail many new and important emerging research questions but also identify key limitations in existing panels in addressing those questions. To address these limitations, we consider the advantages and disadvantages of initiating a new, general-purpose omnibus household panel in the U.S. We also discuss the particular benefits of starting new panels that have specific targeted domains such as child development, population health and health care. We also develop a list of valuable enhancements to existing panels which could address many of their limitations. PMID:26688609

[Remote sensing monitoring and screening for urban black and odorous water body: A review.

PubMed

Shen, Qian; Zhu, Li; Cao, Hong Ye

2017-10-01

Continuous improvement of urban water environment and overall control of black and odorous water body are not merely national strategic needs with the action plan for prevention and treatment of water pollution, but also the hot issues attracting the attention of people. Most previous researches concentrated on the study of cause, evaluation and treatment measures of this phenomenon, and there are few researches on the monitoring using remote sensing, which is often a strain to meet the national needs of operational monitoring. This paper mainly summarized the urgent research problems, mainly including the identification and classification standard, research on the key technologies, and the frame of remote sensing screening systems for the urban black and odorous water body. The main key technologies were concluded too, including the high spatial resolution image preprocessing and extraction technique for black and odorous water body, the extraction of water information in city zones, the classification of the black and odorous water, and the identification and classification technique based on satellite-sky-ground remote sensing. This paper summarized the research progress and put forward research ideas of monitoring and screening urban black and odorous water body via high spatial resolution remote sensing technology, which would be beneficial to having an overall grasp of spatial distribution and improvement progress of black and odorous water body, and provide strong technical support for controlling urban black and odorous water body.

Microplastics in the Ocean.

PubMed

Shim, Won Joon; Thomposon, Richard C

2015-10-01

Since their ubiquity in the ocean and marine organisms was first revealed, global concern about microplastics has grown considerably. The North Pacific Ocean and the adjacent marginal seas have high levels of microplastic contamination compared with the global average. This special issue on microplastics was organized by the North Pacific Marine Science Organization to share information on microplastic pollution in the North Pacific region. The special issue highlights high levels of contamination in the North Pacific both on shorelines and at the sea surface. Particularly high levels of contamination were reported on the western and southern coasts of Korea. Sources, including sewage discharge, aquaculture, and shipyards, were implicated. With the direction and energy of surface winds and currents have an important influence on shoreline patterns of distribution. The special issue also demonstrates potential for ingestion of microplastic by small planktonic organisms at the base of the food chain. A wide range of chemicals are associated with plastic debris and concerns are expressed about the potential for these chemicals to transfer to biota upon ingestion. As an introduction to the topic, this paper provides a brief background on microplastic contamination, highlights some key research gaps, and summarizes findings from the articles published in this issue.

Drugs and Sex. The Nonmedical Use of Drugs and Sexual Behavior. National Institute on Drugs Research Issues 2.

ERIC Educational Resources Information Center

Ferguson, Patricia, Ed.; And Others

This report represents the second in a series intended to summarize the empirical research findings and major theoretical approaches relating to the issues of drug use and abuse. This volume reviews some of the major research findings which explore the relationship between nonmedical drug use and sexual behavior. The research is summarized and…

Doing What It Takes To Make Schools and Communities Drug Free. Conference Proceedings (2nd, Chicago, IL, March 26-28, 1992).

ERIC Educational Resources Information Center

North Central Regional Educational Lab., Elmhurst, IL.

Keynote addresses, issues forums, workshops, and panel discussions from a conference on making schools and communities drug free are summarized in this document. Keynote addresses by Jonathan Kozol, Protase Woodford, and Jeff Howard are summarized. Issues forums are included on the topics of building successful school and community partnerships;…

Statement Summarizing Research Findings on the Issue of the Relationship Between Food-Additive-Free Diets and Hyperkinesis in Children.

ERIC Educational Resources Information Center

Lipton, Morris; Wender, Esther

The National Advisory Committee on Hyperkinesis and Food Additives paper summarized some research findings on the issue of the relationship between food-additive-free diets and hyperkinesis in children. Based on several challenge studies, it is concluded that the evidence generally refutes Dr. B. F. Feingold's claim that artificial colorings in…

Health Sector Reform in the Kurdistan Region - Iraq: Financing Reform, Primary Care, and Patient Safety.

PubMed

Anthony, C Ross; Moore, Melinda; Hilborne, Lee H; Mulcahy, Andrew W

2014-12-30

In 2010, the Kurdistan Regional Government asked the RAND Corporation to help guide reform of the health care system in the Kurdistan Region of Iraq. The overarching goal of reform was to help establish a health system that would provide high-quality services efficiently to everyone to prevent, treat, and manage physical and mental illnesses and injuries. This article summarizes the second phase of RAND's work, when researchers analyzed three distinct but intertwined health policy issue areas: development of financing policy, implementation of early primary care recommendations, and evaluation of quality and patient safety. For health financing, the researchers reviewed the relevant literature, explored the issue in discussions with key stakeholders, developed and assessed various policy options, and developed plans or approaches to overcome barriers and achieve stated policy objectives. In the area of primary care, they developed and helped to implement a new management information system. In the area of quality and patient safety, they reviewed relevant literature, discussed issues and options with health leaders, and recommended an approach toward incremental implementation.

Consensus Development from the 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014)

PubMed Central

Hsu, Chiun; Chen, Bang-Bin; Chen, Chien-Hung; Ho, Ming-Chih; Cheng, Jason Chia-Hsien; Kokudo, Norihiro; Murakami, Takamichi; Yeo, Winnie; Seong, Jinsil; Jia, Ji-Dong; Han, Kwan-Hyub; Cheng, Ann-Lii

2015-01-01

A key mission of the Asia-Pacific Primary Liver Cancer Expert (APPLE) Association is to ensure a coherent view for management of hepatocellular carcinoma (HCC) and to advance new treatment for this difficult disease. At the 5th APPLE meeting, held in July 2014 in Taipei, Taiwan, an APPLE consensus development program was established to facilitate discussion among experts in the Asia-Pacific region on pertinent issues for HCC management, including (1) surgery for intermediate/advanced-stage disease, (2) prevention of HCC recurrence after curative treatment, (3) optimizing imaging diagnosis, (4) radiotherapy: current practice and future clinical trials, and (5) the role of cytotoxic chemotherapy. A pre-congress questionnaire was undertaken with the consensus development committee members to help understand the current practice patterns for HCC in the Asia-Pacific region and to identify issues relating to optimal patient care and further clinical trials for which consensus needs to be developed. In this report, the results of the questionnaire are presented, and the pertinent issues identified by each consensus group for further discussion and consensus development are summarized. PMID:26020032

Human Health Effects of Dichloromethane: Key Findings and Scientific Issues

PubMed Central

Schlosser, Paul M.; Bale, Ambuja S.; Gibbons, Catherine F.; Wilkins, Amina

2014-01-01

Background: The U.S. EPA’s Integrated Risk Information System (IRIS) completed an updated toxicological review of dichloromethane in November 2011. Objectives: In this commentary we summarize key results and issues of this review, including exposure sources, identification of potential health effects, and updated physiologically based pharmacokinetic (PBPK) modeling. Methods: We performed a comprehensive review of primary research studies and evaluation of PBPK models. Discussion: Hepatotoxicity was observed in oral and inhalation exposure studies in several studies in animals; neurological effects were also identified as a potential area of concern. Dichloromethane was classified as likely to be carcinogenic in humans based primarily on evidence of carcinogenicity at two sites (liver and lung) in male and female B6C3F1 mice (inhalation exposure) and at one site (liver) in male B6C3F1 mice (drinking-water exposure). Recent epidemiologic studies of dichloromethane (seven studies of hematopoietic cancers published since 2000) provide additional data raising concerns about associations with non-Hodgkin lymphoma and multiple myeloma. Although there are gaps in the database for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissues in vivo), the positive DNA damage assays correlated with tissue and/or species availability of functional glutathione S-transferase (GST) metabolic activity, the key activation pathway for dichloromethane-induced cancer. Innovations in the IRIS assessment include estimation of cancer risk specifically for a presumed sensitive genotype (GST-theta-1+/+), and PBPK modeling accounting for human physiological distributions based on the expected distribution for all individuals 6 months to 80 years of age. Conclusion: The 2011 IRIS assessment of dichloromethane provides insights into the toxicity of a commonly used solvent. Citation: Schlosser PM, Bale AS, Gibbons CF, Wilkins A, Cooper GS. 2015. Human health effects of dichloromethane: key findings and scientific issues. Environ Health Perspect 123:114–119; http://dx.doi.org/10.1289/ehp.1308030 PMID:25325283

[Applications of stable isotope analysis in the trophic ecology studies of cephalopods].

PubMed

Li, Yun-Kai; Gong, Yi; Chen, Xin-Jun

2014-05-01

Cephalopods play an important role in marine food webs, however, knowledge about their complex life history, especially their feeding ecology, remains limited. With the rapidly increasing use of stable isotope analysis (SIA) in ecology, it becomes a powerful tool and complement of traditional methods for investigating the trophic ecology and migration patterns of invertebrates. Here, after summarizing the current methods for trophic ecology investigation of cephalopods, applications of SIA in studying the trophic ecology of cephalopods were reviewed, including the key issues such as standardization of available tissues for SIA analyzing, diet shift and migration patterns of cephalopods, with the aim of advancing its application in the biology of cephalopods in the future.

Databases toward Disseminated Use - Nikkei News Telecom -

NASA Astrophysics Data System (ADS)

Kasiwagi, Akira

The need for “searchers” - adept hands in the art of information retrieval - is increasing nowadays. Searchers have become necessary as the result of the upbeat online database market. The number of database users is rising steeply. There is the urgent need to develop potential users of general information, such as newspaper articles. Simple commands, easy operation, and low prices hold the key to general popularization of databases, and the issue lies in how the industry will get about achieving this task. Nihon Keizai Shimbun has been undertaking a wide range of possibilities with Nikkei News Telecom. Although only two years have passed since its start, results of Nikkei’s efforts are summarized below.

The impact of suicide on the family.

PubMed

Cerel, Julie; Jordan, John R; Duberstein, Paul R

2008-01-01

Little research has examined the consequences of a suicide for social or family networks. Because suicide occurs within families, the focus on the aftermath of suicide within families is an important next step to determine exactly how to help survivors. In this article, we review and summarize the research on the impact of suicide on individuals within families and on family and social networks. We begin with a discussion of family changes following suicide. Next, we discuss the effects of suicide on social networks overall and responses of children and the elderly to a suicide in the family. Finally, we identify key issues that remain to be resolved in family survivor research and make recommendations for future studies.

Clinical practice guideline: allergic rhinitis executive summary.

PubMed

Seidman, Michael D; Gurgel, Richard K; Lin, Sandra Y; Schwartz, Seth R; Baroody, Fuad M; Bonner, James R; Dawson, Douglas E; Dykewicz, Mark S; Hackell, Jesse M; Han, Joseph K; Ishman, Stacey L; Krouse, Helene J; Malekzadeh, Sonya; Mims, James Whit W; Omole, Folashade S; Reddy, William D; Wallace, Dana V; Walsh, Sandra A; Warren, Barbara E; Wilson, Meghan N; Nnacheta, Lorraine C

2015-02-01

The American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) has published a supplement to this issue featuring the new Clinical Practice Guideline: Allergic Rhinitis. To assist in implementing the guideline recommendations, this article summarizes the rationale, purpose, and key action statements. The 14 recommendations developed address the evaluation of patients with allergic rhinitis, including performing and interpretation of diagnostic testing and assessment and documentation of chronic conditions and comorbidities. It will then focus on the recommendations to guide the evaluation and treatment of patients with allergic rhinitis, to determine the most appropriate interventions to improve symptoms and quality of life for patients with allergic rhinitis. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

An overview of rotating machine systems with high-temperature bulk superconductors

NASA Astrophysics Data System (ADS)

Zhou, Difan; Izumi, Mitsuru; Miki, Motohiro; Felder, Brice; Ida, Tetsuya; Kitano, Masahiro

2012-10-01

The paper contains a review of recent advancements in rotating machines with bulk high-temperature superconductors (HTS). The high critical current density of bulk HTS enables us to design rotating machines with a compact configuration in a practical scheme. The development of an axial-gap-type trapped flux synchronous rotating machine together with the systematic research works at the Tokyo University of Marine Science and Technology since 2001 are briefly introduced. Developments in bulk HTS rotating machines in other research groups are also summarized. The key issues of bulk HTS machines, including material progress of bulk HTS, in situ magnetization, and cooling together with AC loss at low-temperature operation are discussed.

Multijunction cells for concentrators: Technology prospects

NASA Technical Reports Server (NTRS)

Ferber, R. R. (Compiler); Costogue, E. N. (Compiler); Shimada, K. (Compiler)

1984-01-01

Development of high-efficiency multijunction solar cells for concentrator applications is a key step in achieving the goals of the U.S. Department of Energy National Photovoltaics Program. This report summarizes findings of an issue study conducted by the Jet Propulsion Laboratory Photovoltaic Analysis and Integration Center, with the assistance of the Solar Energy Research Institute and Sandia National laboratoies, which surveyed multijunction cell research for concentrators undertaken by federal agencies and by private industry. The team evaluated the potentials of research activities sponsored by DOE and by corporate funding to achieve projected high-efficiency goals and developed summary statements regarding industry expectations. Recommendations are made for the direction of future work to address specific unresolved aspects of multijunction cell technology.

Report of the National Heart, Lung, and Blood Institute Working Group: An Integrated Network for Congenital Heart Disease Research

PubMed Central

Pasquali, Sara K.; Jacobs, Jeffrey P.; Farber, Gregory K.; Bertoch, David; Blume, Elizabeth D.; Burns, Kristin M.; Campbell, Robert; Chang, Anthony C.; Chung, Wendy K.; Riehle-Colarusso, Tiffany; Curtis, Lesley H.; Forrest, Christopher B.; Gaynor, William J.; Gaies, Michael G.; Go, Alan S.; Henchey, Paul; Martin, Gerard R.; Pearson, Gail; Pemberton, Victoria L.; Schwartz, Steven M.; Vincent, Robert; Kaltman, Jonathan R.

2016-01-01

The National Heart, Lung, and Blood Institute convened a Working Group in January 2015 to explore issues related to an integrated data network for congenital heart disease (CHD) research. The overall goal was to develop a common vision for how the rapidly increasing volumes of data captured across numerous sources can be managed, integrated, and analyzed to improve care and outcomes. This report summarizes the current landscape of CHD data, data integration methodologies used across other fields, key considerations for data integration models in CHD, and the short- and long-term vision and recommendations made by the Working Group. PMID:27045129

Global climate change: A strategic issue facing Illinois

DOE Office of Scientific and Technical Information (OSTI.GOV)

Womeldorff, P.J.

1995-12-31

This paper discusses global climate change, summarizes activities related to climate change, and identifies possible outcomes of the current debate on the subject. Aspects of climate change related to economic issues are very briefly summarized; it is suggested that the end result will be a change in lifestyle in developed countries. International activities, with an emphasis on the Framework Convention on Climate Change, and U.S. activities are outlined. It is recommended that the minimum action required is to work to understand the issue and prepare for possible action.

Capacity for ethical and regulatory review of herbal trials in developing countries: a case study of Moringa oleifera research in HIV-infected patients.

PubMed

Monera-Penduka, Tsitsi G; Maponga, Charles C; Morse, Gene D; Nhachi, Charles F B

2017-01-01

Lack of regulatory capacity limits the conduct of ethical and rigorous trials of herbal medicines in developing countries. Sharing ethical and regulatory experiences of successful herbal trials may accelerate the field while assuring human subjects protection. The methods and timelines for the ethical and regulatory review processes for the first drug regulatory authority approved herbal trial in Zimbabwe are described in this report. The national drug regulatory authority and ethics committee were engaged for pre-submission discussions. Six applications were submitted. Application procedures and communications with the various regulatory and ethics review boards were reviewed. Key issues raised and timelines for communications were summarized. There was no special framework for the approval of herbal trials. One local institutional review committee granted an exemption. Key issues raised for revision were around pre-clinical efficacy and safety data, standardization and quality assurance of the intervention as well as consenting procedures. Approval timelines ranged between eight and 72 weeks. In the absence of a defined framework for review of herbal trials, approval processes can be delayed. Dialogue between researchers and regulators is important for successful and efficient protocol approval for herbal trials in developing countries. The study was registered prospectively on August 3, 2011 with clinicaltrials.gov (NCT01410058).

Recent advances in automotive catalysis for NOx emission control by small-pore microporous materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beale, Andrew M.; Gao, Feng; Lezcano-Gonzalez, Ines

The ever increasing demand to develop highly fuel efficient engines coincides with the need to minimize air pollution originating from the exhaust gases of internal combustion engines. Dramatically improved fuel efficiency can be achieved at air-to-fuel ratios much higher than stoichiometric. In the presence of oxygen in large excess, however, traditional three-way catalysts are unable to reduce NOx. Among the number of lean-NOx reduction technologies, selective catalytic reduction (SCR) of NOx by NH3 over Cu- and Fe-ion exchanged zeolite catalysts has been extensively studied over the past 30+ years. Despite the significant advances in developing a viable practical zeolite-based catalystmore » for lean NOx reduction, the insufficient hydrothermal stabilities of the zeolite structures considered cast doubts about their real-world applicability. During the past decade a renewed interest in zeolite-based lean NOx reduction was spurred by the discovery of the very high activity of Cu-SSZ-13 (and the isostructural Cu-SAPO-34) in the NH3 SCR of NOx. These new, small-pore zeolite-based catalysts not only exhibited very high NOx conversion and N2 selectivity, but also exhibited exceptional high hydrothermal stability at high temperatures. In this review we summarize the key discoveries of the past ~5 years that lead to the introduction of these catalysts into practical application. The review first briefly discusses the structure and preparation of the CHA structure-based zeolite catalysts, and then summarizes the key learnings of the rather extensive (but not complete) characterisation work. Then we summarize the key findings of reaction kinetics studies, and provide some mechanistic details emerging from these investigations. At the end of the review we highlight some of the issues that are still need to be addressed in automotive exhaust control catalysis. Funding A.M.B. and I.L.G. would like to thank EPSRC for funding. F.G., C.H.F.P. and J.Sz. gratefully acknowledge financial support from the US Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program.« less

Soil Vapor Extraction Implementation Experiences

EPA Pesticide Factsheets

This issue paper identifies issues and summarizes experiences with soil vapor extraction (SVE) as a remedy for volatile organic compounds (VOCs) in soils. The issues presented here reflect discussions with over 30 Remedial Project Managers (RPMs)...

Safety and Regulatory Issues of the Thorium Fuel Cycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ade, Brian; Worrall, Andrew; Powers, Jeffrey

2014-02-01

Thorium has been widely considered an alternative to uranium fuel because of its relatively large natural abundance and its ability to breed fissile fuel (233U) from natural thorium (232Th). Possible scenarios for using thorium in the nuclear fuel cycle include use in different nuclear reactor types (light water, high temperature gas cooled, fast spectrum sodium, molten salt, etc.), advanced accelerator-driven systems, or even fission-fusion hybrid systems. The most likely near-term application of thorium in the United States is in currently operating light water reactors (LWRs). This use is primarily based on concepts that mix thorium with uranium (UO2 + ThO2),more » add fertile thorium (ThO2) fuel pins to LWR fuel assemblies, or use mixed plutonium and thorium (PuO2 + ThO2) fuel assemblies. The addition of thorium to currently operating LWRs would result in a number of different phenomenological impacts on the nuclear fuel. Thorium and its irradiation products have nuclear characteristics that are different from those of uranium. In addition, ThO2, alone or mixed with UO2 fuel, leads to different chemical and physical properties of the fuel. These aspects are key to reactor safety-related issues. The primary objectives of this report are to summarize historical, current, and proposed uses of thorium in nuclear reactors; provide some important properties of thorium fuel; perform qualitative and quantitative evaluations of both in-reactor and out-of-reactor safety issues and requirements specific to a thorium-based fuel cycle for current LWR reactor designs; and identify key knowledge gaps and technical issues that need to be addressed for the licensing of thorium LWR fuel in the United States.« less

Biomimetic materials in the utility industry: A program plan for research opportunities, volume 2. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richman, R.H.; McNaughton, W.P.

1996-09-01

This report is the second of a two-volume set addressing the state-of-the-art and outlook for the application of biomimetic materials. The first volume examined achievements in mimicking novel aspects of biological systems in five broad categories: (1) Mimicking of Natural Material Designs, (2) Biomimetic Materials Processing, (3) Artificial Photosynthesis, (4) Biomimetic Molecular Electronics, and (5) Biomimetic Catalysis. Each topic was examined as to current activities and approaches, key aspects, unresolved issues, and implications for the power industry. Key researchers, their organizations, the main thrusts of investigation, achievements, and funding agencies were also summarized. This volume highlights opportunities for future researchmore » activities in biomimetics that could be valuable to the U.S. utility industry. Nineteen specific research projects have been identified. These opportunities are outlined in four classes: (1) technology awareness, (2) modeling and experimental studies, (3) state-of-the-art and outlook studies: developing experimental plans, and (4) concept feasibility studies.« less

Linking an agency strategic review to increase knowledge management: San Francisco County Human Service Agency.

PubMed

Harrison, Lindsay

2012-01-01

Led by the agency director, the agency engaged in a Strategic Review, based on a comprehensive assessment of agency performance that identified strategies to improve organizational effectiveness through increased data-informed practice and knowledge management. The Strategic Review gathered information on staff perceptions, perceptions of external stakeholders, changing citywide and neighborhood demographics, policy mandates, and budget and workload issues. The need for the review was based upon multiple, substantial changes not addressed in the 2000 Strategic Plan, including the 2004 merger of the Department of Human Services and the Department of Aging and Adult Services, changes among the executive management team, transitions among key political entities, new policy mandates and changing budget allocations. This case study describes the Strategic Review process and content, summarizing key challenges and lessons related to addressing workload demands, fostering positive staff attitudes, balancing internal and external information needs, and integrating data use and planning processes across the agency. Copyright © Taylor & Francis Group, LLC

The Today and Likely Tomorrow of American Race Relations

ERIC Educational Resources Information Center

Ashmore, Richard D.

1976-01-01

An introduction to a Special issue of the Journal of Social Issues (JSI) by the guest editor, which reviews psychology's concerns with race relations and race related issues during the fifties, sixties and seventies, summarizes past JSI issues pertinent to those issues, and introduces the ten articles in this issue. (Author/JM)

Recent progress in stabilizing hybrid perovskites for solar cell applications

NASA Astrophysics Data System (ADS)

Chen, Jianqing; Cai, Xin; Yang, Donghui; Song, Dan; Wang, Jiajia; Jiang, Jinghua; Ma, Aibin; Lv, Shiquan; Hu, Michael Z.; Ni, Chaoying

2017-07-01

Hybrid inorganic-organic perovskites have quickly evolved as a promising group of materials for solar cells and optoelectronic applications mainly owing to the inexpensive materials, relatively simple and versatile fabrication and high power conversion efficiency (PCE). The certified energy conversion efficiency for perovskite solar cell (PSC) has reached above 20%, which is compatible to the current best for commercial applications. However, long-term stabilities of the materials and devices remain to be the biggest challenging issue for realistic implementation of the PSCs. This article discusses the key issues related to the stability of perovskite absorbing layer including crystal structural stability, chemical stability under moisture, oxygen, illumination and interface reaction, effects of electron-transporting materials (ETM), hole-transporting materials (HTM), contact electrodes, ion migration and preparation conditions. Towards the end, prospective strategies for improving the stability of PSCs are also briefly discussed and summarized. We focus on recent understanding of the stability of materials and devices and our perspectives about the strategies for the stability improvement.

Signal Transduction: From the Atomic Age to the Post-Genomic Era

PubMed Central

Thorner, Jeremy; Hunter, Tony; Cantley, Lewis C.; Sever, Richard

2014-01-01

We have come a long way in the 55 years since Edmond Fischer and the late Edwin Krebs discovered that the activity of glycogen phosphorylase is regulated by reversible protein phosphorylation. Many of the fundamental molecular mechanisms that operate in biological signaling have since been characterized and the vast web of interconnected pathways that make up the cellular signaling network has been mapped in considerable detail. Nonetheless, it is important to consider how fast this field is still moving and the issues at the current boundaries of our understanding. One must also appreciate what experimental strategies have allowed us to attain our present level of knowledge. We summarize here some key issues (both conceptual and methodological), raise unresolved questions, discuss potential pitfalls, and highlight areas in which our understanding is still rudimentary. We hope these wide-ranging ruminations will be useful to investigators who carry studies of signal transduction forward during the rest of the 21st century. PMID:25359498

Survey of Ultra-wideband Radar

NASA Astrophysics Data System (ADS)

Mokole, Eric L.; Hansen, Pete

The development of UWB radar over the last four decades is very briefly summarized. A discussion of the meaning of UWB is followed by a short history of UWB radar developments and discussions of key supporting technologies and current UWB radars. Selected UWB radars and the associated applications are highlighted. Applications include detecting and imaging buried mines, detecting and mapping underground utilities, detecting and imaging objects obscured by foliage, through-wall detection in urban areas, short-range detection of suicide bombs, and the characterization of the impulse responses of various artificial and naturally occurring scattering objects. In particular, the Naval Research Laboratory's experimental, low-power, dual-polarized, short-pulse, ultra-high resolution radar is used to discuss applications and issues of UWB radar. Some crucial issues that are problematic to UWB radar are spectral availability, electromagnetic interference and compatibility, difficulties with waveform control/shaping, hardware limitations in the transmission chain, and the unreliability of high-power sources for sustained use above 2 GHz.

Quantitative Modeling of Coupled Piezo-Elastodynamic Behavior of Piezoelectric Actuators Bonded to an Elastic Medium for Structural Health Monitoring: A Review

PubMed Central

Huang, Guoliang; Song, Fei; Wang, Xiaodong

2010-01-01

Elastic waves, especially guided waves, generated by a piezoelectric actuator/sensor network, have shown great potential for on-line health monitoring of advanced aerospace, nuclear, and automotive structures in recent decades. Piezoelectric materials can function as both actuators and sensors in these applications due to wide bandwidth, quick response and low costs. One of the most fundamental issues surrounding the effective use of piezoelectric actuators is the quantitative evaluation of the resulting elastic wave propagation by considering the coupled piezo-elastodynamic behavior between the actuator and the host medium. Accurate characterization of the local interfacial stress distribution between the actuator and the host medium is the key issue for the problem. This paper presents a review of the development of analytical, numerical and hybrid approaches for modeling of the coupled piezo-elastodynamic behavior. The resulting elastic wave propagation for structural health monitoring is also summarized. PMID:22319319

Security Considerations for E-Mental Health Interventions

PubMed Central

Bennett, Anthony James; Griffiths, Kathleen Margaret

2010-01-01

Security considerations are an often overlooked and underfunded aspect of the development, delivery, and evaluation of e-mental health interventions although they are crucial to the overall success of any eHealth project. The credibility and reliability of eHealth scientific research and the service delivery of eHealth interventions rely on a high standard of data security. This paper describes some of the key methodological, technical, and procedural issues that need to be considered to ensure that eHealth research and intervention delivery meet adequate security standards. The paper concludes by summarizing broad strategies for addressing the major security risks associated with eHealth interventions. These include involving information technology (IT) developers in all stages of the intervention process including its development, evaluation, and ongoing delivery; establishing a wide-ranging discourse about relevant security issues; and familiarizing researchers and providers with the security measures that must be instituted in order to protect the integrity of eHealth interventions. PMID:21169173

NRC Continental Margins Workshop

NASA Astrophysics Data System (ADS)

Katsouros, Mary Hope

The Ocean Studies Board of the National Research Council is organizing a workshop, “Continental Margins: Evolution of Passive Continental Margins and Active Marginal Processes,” to stimulate discussion and longterm planning in the scientific community about the evolution of all types of continental margins. We want to coordinate academic, industry, and government agency efforts in this field, and to enhance communication between sea-based and land-based research programs.The continental margins constitute the only available record of the long-term dynamic interaction of oceanic and continental lithosphere. Of great interest are the unique structures and thick sedimentary sequences associated with this interaction. A major focus of the workshop will be to define strategies for exploring and understanding the continental margins in three dimensions and through geologic time. The workshop will be divided into 7 working groups, each concentrating on a major issue in continental margins research. A background document is being prepared summarizing recent research in specific continental margin fields and identifying key scientific and technical issues.

Engineering Issue: Technology Alternatives for the Remediation of PCB Contaminated Soils and Sediments

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Engineering Issue papers are a series of documents that summarize the available information on specific contaminates, selected treatment and site remediation technologies, and related issues. This Engineering Issue paper is intended...

Computationally Driven Two-Dimensional Materials Design: What Is Next?

DOE PAGES

Pan, Jie; Lany, Stephan; Qi, Yue

2017-07-17

Two-dimensional (2D) materials offer many key advantages to innovative applications, such as spintronics and quantum information processing. Theoretical computations have accelerated 2D materials design. In this issue of ACS Nano, Kumar et al. report that ferromagnetism can be achieved in functionalized nitride MXene based on first-principles calculations. Their computational results shed light on a potentially vast group of materials for the realization of 2D magnets. In this Perspective, we briefly summarize the promising properties of 2D materials and the role theory has played in predicting these properties. Additionally, we discuss challenges and opportunities to boost the power of computation formore » the prediction of the 'structure-property-process (synthesizability)' relationship of 2D materials.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gu, Meng; He, Yang; Zheng, Jianming

Silicon (Si), associated with its natural abundance, low discharge voltage vs. Li/Li+, and extremely high theoretical discharge capacity (~ 4200 mAh g-1,), has been extensively explored as anode for lithium ion battery. One of the key challenges for using Si as anode is the large volume change upon lithiation and delithiation, which causes a fast capacity fading. Over the last few years, dramatic progress has been made for addressing this issue. In this paper, we summarize the progress towards tailoring of Si as anode for lithium ion battery. The paper is organized such that it covers the fundamentals, the promisemore » offered based on nanoscale designing, and the remaining challenges that need to be attacked to allow using of Si based materials as anode for battery.« less

Multipurpose prevention technologies: the future of HIV and STI protection

PubMed Central

2015-01-01

Every day, more than 1 million people are newly infected with sexually transmitted infections (STIs) that can lead to morbidity, mortality, and an increased risk of human immunodeficiency virus (HIV) acquisition. Existing prevention and management strategies, including behavior change, condom promotion, and therapy have not reduced the global incidence and prevalence, pointing to the need for novel innovative strategies. This review summarizes important issues raised during a satellite session at the first HIV R4P conference, held in Cape Town, on October 31, 2014. We explore key STIs that are challenging public health today; new biomedical prevention approaches including multipurpose prevention technologies (MPTs); and the scientific and regulatory hurdles that must be overcome to make combination prevention tools a reality. PMID:25759332

Toward Large-Area Sub-Arcsecond X-Ray Telescopes

NASA Technical Reports Server (NTRS)

O'Dell, Stephen L.; Aldcroft, Thomas L.; Allured, Ryan; Atkins, Carolyn; Burrows, David N.; Cao, Jian; Chalifoux, Brandon D.; Chan, Kai-Wing; Cotroneo, Vincenzo; Elsner, Ronald F.;

Hazardous healthcare waste management in the Kingdom of Bahrain.

PubMed

Mohamed, L F; Ebrahim, S A; Al-Thukair, A A

2009-08-01

Hazardous healthcare waste has become an environmental concern for many developing countries including the Kingdom of Bahrain. There have been several significant obstacles facing the Kingdom in dealing with this issue including; limited documentation regarding generation, handling, management, and disposal of waste. This in turn hinders efforts to plan better healthcare waste management. In this paper, hazardous waste management status in the Kingdom has been investigated through an extensive survey carried out on selected public and private healthcare premises. Hazardous waste management practices including: waste generation, segregation, storage, collection, transportation, treatment, and disposal were determined. The results of this study along with key findings are discussed and summarized. In addition; several effective recommendations and improvements of hazardous waste management are suggested.

Accelerating Innovation that Enhances Resource Recovery in the Wastewater Sector: Advancing a National Testbed Network.

PubMed

Mihelcic, James R; Ren, Zhiyong Jason; Cornejo, Pablo K; Fisher, Aaron; Simon, A J; Snyder, Seth W; Zhang, Qiong; Rosso, Diego; Huggins, Tyler M; Cooper, William; Moeller, Jeff; Rose, Bob; Schottel, Brandi L; Turgeon, Jason

2017-07-18

This Feature examines significant challenges and opportunities to spur innovation and accelerate adoption of reliable technologies that enhance integrated resource recovery in the wastewater sector through the creation of a national testbed network. The network is a virtual entity that connects appropriate physical testing facilities, and other components needed for a testbed network, with researchers, investors, technology providers, utilities, regulators, and other stakeholders to accelerate the adoption of innovative technologies and processes that are needed for the water resource recovery facility of the future. Here we summarize and extract key issues and developments, to provide a strategy for the wastewater sector to accelerate a path forward that leads to new sustainable water infrastructures.

The Security Email Based on Smart Card

NASA Astrophysics Data System (ADS)

Lina, Zhang; Jiang, Meng Hai.

Email has become one of the most important communication tools in modern internet society, and its security is an important issue that can't be ignored. The security requirements of Email can be summarized as confidentiality, integrity, authentication and non-repudiation. Recently many researches on IBE (identify based encrypt) have been carried out to solve these security problems. However, because of IBE's fatal flaws and great advantages of PKI (Public Key Infrastructure), PKI is found to be still irreplaceable especially in the applications based on smart card. In this paper, a construction of security Email is presented, then the design of relatively cryptography algorithms and the configuration of certificates are elaborated, and finally the security for the proposed system is discussed.

Hazardous healthcare waste management in the Kingdom of Bahrain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohamed, L.F.; Ebrahim, S.A.; Al-Thukair, A.A.

2009-08-15

Hazardous healthcare waste has become an environmental concern for many developing countries including the Kingdom of Bahrain. There have been several significant obstacles facing the Kingdom in dealing with this issue including; limited documentation regarding generation, handling, management, and disposal of waste. This in turn hinders efforts to plan better healthcare waste management. In this paper, hazardous waste management status in the Kingdom has been investigated through an extensive survey carried out on selected public and private healthcare premises. Hazardous waste management practices including: waste generation, segregation, storage, collection, transportation, treatment, and disposal were determined. The results of this studymore » along with key findings are discussed and summarized. In addition; several effective recommendations and improvements of hazardous waste management are suggested.« less

Green Power Marketing in the United States. A Status Report (2009 Data)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bird, Lori; Sumner, Jenny

This report documents green power marketing activities and trends in the United States. First, aggregate green power sales data for all voluntary purchase markets across the United States are presented. Next, we summarize data on utility green pricing programs offered in regulated electricity markets; green power marketing activity in competitive electricity markets, as well as green power sold to voluntary purchasers in the form of RECs; and renewable energy sold as greenhouse gas offsets in the United States. Finally, this is followed by a discussion of key market trends and issues. The data presented in this report are based primarilymore » on figures provided to NREL by utilities and independent renewable energy marketers.« less

Green Power Marketing in the United States: A Status Report (2009 Data)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bird, L.; Sumner, J.

This report documents green power marketing activities and trends in the United States. First, aggregate green power sales data for all voluntary purchase markets across the United States are presented. Next, we summarize data on utility green pricing programs offered in regulated electricity markets; green power marketing activity in competitive electricity markets, as well as green power sold to voluntary purchasers in the form of RECs; and renewable energy sold as greenhouse gas offsets in the United States. Finally, this is followed by a discussion of key market trends and issues. The data presented in this report are based primarilymore » on figures provided to NREL by utilities and independent renewable energy marketers.« less

Direction and Integration of Experimental Ground Test Capabilities and Computational Methods

NASA Technical Reports Server (NTRS)

Dunn, Steven C.

2016-01-01

This paper groups and summarizes the salient points and findings from two AIAA conference panels targeted at defining the direction, with associated key issues and recommendations, for the integration of experimental ground testing and computational methods. Each panel session utilized rapporteurs to capture comments from both the panel members and the audience. Additionally, a virtual panel of several experts were consulted between the two sessions and their comments were also captured. The information is organized into three time-based groupings, as well as by subject area. These panel sessions were designed to provide guidance to both researchers/developers and experimental/computational service providers in defining the future of ground testing, which will be inextricably integrated with the advancement of computational tools.

Introducing a primer for career development and promotion: succeeding as a psychologist in an academic health center.

PubMed

Christophersen, Edward; Butt, Zeeshan

2012-12-01

Noting a lack of such a resource, the authors developed a primer summarizing key concepts for career development and promotion for psychologists working in an academic health center. The present article presents a brief summary of the primer; however, the full version is available as an APAHC membership benefit (or for a small fee for non-members) by visiting http://www.div12.org/section8/index.html and is a supplement to the December issue of Volume 19 of the Journal of Clinical Psychology in Medical Settings (Supplementary material 1). The primer complements other APAHC membership benefits, which may be helpful for early career or more seasoned psychologists planning for career transitions.

An introduction to multiplicity issues in clinical trials: the what, why, when and how.

PubMed

Li, Guowei; Taljaard, Monica; Van den Heuvel, Edwin R; Levine, Mitchell Ah; Cook, Deborah J; Wells, George A; Devereaux, Philip J; Thabane, Lehana

2017-04-01

In clinical trials it is not uncommon to face a multiple testing problem which can have an impact on both type I and type II error rates, leading to inappropriate interpretation of trial results. Multiplicity issues may need to be considered at the design, analysis and interpretation stages of a trial. The proportion of trial reports not adequately correcting for multiple testing remains substantial. The purpose of this article is to provide an introduction to multiple testing issues in clinical trials, and to reduce confusion around the need for multiplicity adjustments. We use a tutorial, question-and-answer approach to address the key issues of why, when and how to consider multiplicity adjustments in trials. We summarize the relevant circumstances under which multiplicity adjustments ought to be considered, as well as options for carrying out multiplicity adjustments in terms of trial design factors including Population, Intervention/Comparison, Outcome, Time frame and Analysis (PICOTA). Results are presented in an easy-to-use table and flow diagrams. Confusion about multiplicity issues can be reduced or avoided by considering the potential impact of multiplicity on type I and II errors and, if necessary pre-specifying statistical approaches to either avoid or adjust for multiplicity in the trial protocol or analysis plan. © The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

IN-SITU CHEMICAL OXIDATION--ENGINEERING ISSUE

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Engineering Issue Papers are a series of technology transfer documents that summarize the latest available information on specific technical issues, including fate and transport, specific contaminants, selected treatment and site rem...

Summary of the EMA Joint Regulators/Industry QbD workshop (London, UK; 28-29 January 2014).

PubMed

Cook, Graham; France, Georges; Holte, Øyvind; Lorenti, Giampiero; Tainsh, David

2016-01-01

This paper summarizes the discussions and insights gained from the key themes that emerged during the Quality by Design (QbD) Workshop held at the European Medicines Agency (EMA) offices in London, UK, on 28-29 January 2014. Industry and regulators shared practical experiences from six case studies (five approved small molecule products and one phase 3 biotechnological product) based on QbD submissions by five companies (AstraZeneca, GlaxoSmithKline, Novartis, NovoNordisk, and Pfizer).The case studies covered a range of different development, regulatory submission, and post-approval aspects of QbD and were developed through confidential discussions between the company representatives and regulators. Key themes that emerged from the workshop discussions were: 1. presentation of information in submissions (development story and the presentation of information in marketing authorization applications; risk assessment and criticality); 2. development aspects (design space; use of models; control strategy); and 3. post-approval aspects (lifecycle management; dossier-quality system interactions; handling of deviations). Many aspects of QbD for biotechnological products are similar to small molecules, but there are some important differences highlighted in this paper.The final section of the paper discusses some proposals for future developments to address the issues that were identified. This paper summarizes the discussions and insights gained from the key themes that emerged during the Quality by Design (QbD) Workshop held at the European Medicines Agency offices in London, UK, on 28-29 January 2014. Industry and regulators shared practical experiences from six case studies (five approved small-molecule products and one phase 3 biotechnological product) based on QbD submissions by five companies (AstraZeneca, GlaxoSmithKline, Novartis, NovoNordisk, and Pfizer).The case studies covered a range of different development, regulatory submission, and post-approval aspects of QbD and were developed through confidential discussions between the company representatives and regulators. Key themes that emerged from the workshop discussions were: 1. presentation of information in submissions (development story and the presentation of information in marketing authorization applications; risk assessment and criticality); 2. development aspects (design space; use of models; control strategy); and 3. post-approval aspects (lifecycle management; dossier-quality system interactions; handling of deviations). Many aspects of QbD for biotechnological products are similar to small molecules, but there are some important differences highlighted in this paper.The final section of the paper discusses some proposals for future developments to address the issues that were identified. © PDA, Inc. 2016.

Report from the Workshop on Coregonine Restoration Science

USGS Publications Warehouse

Bronte, Charles R.; Bunnell, David B.; David, Solomon R.; Gordon, Roger; Gorsky, Dimitry; Millard, Michael J.; Read, Jennifer; Stein, Roy A.; Vaccaro, Lynn

2017-08-03

SummaryGreat Lakes fishery managers have the opportunity and have expressed interest in reestablishing a native forage base in the Great Lakes consisting of various forms and species within the genus Coregonus. This report summarizes the proceedings of a workshop focused on a subset of the genus, and the term “coregonines” is used to refer to several species of deepwater ciscoes (also known as “chubs”) and the one more pelagic-oriented cisco species (Coregonus artedi, also known as “lake herring”). As the principal conservation agency for the United States Government, the Department of Interior has unique and significant authorities and capacities to support a coregonine reestablishment program in the Great Lakes. To identify and discuss key uncertainties associated with such a program and develop a coordinated approach, the U.S. Geological Survey (USGS) and the U.S. Fish and Wildlife Service (FWS), the principal Department of the Interior bureaus to address Great Lakes fishery issues, held the first of a series of workshops on coregonine science in Ann Arbor, Michigan, on October 11–13, 2016. Workshop objectives were to identify (1) perceived key uncertainties associated with coregonine restoration in the Great Lakes and (2) DOI capacities for addressing these key uncertainties.

Animal and human innovation: novel problems and novel solutions.

PubMed

Reader, Simon M; Morand-Ferron, Julie; Flynn, Emma

2016-03-19

This theme issue explores how and why behavioural innovation occurs, and the consequences of innovation for individuals, groups and populations. A vast literature on human innovation exists, from the development of problem-solving in children, to the evolution of technology, to the cultural systems supporting innovation. A more recent development is a growing literature on animal innovation, which has demonstrated links between innovation and personality traits, cognitive traits, neural measures, changing conditions, and the current state of the social and physical environment. Here, we introduce these fields, define key terms and discuss the potential for fruitful exchange between the diverse fields researching innovation. Comparisons of innovation between human and non-human animals provide opportunities, but also pitfalls. We also summarize some key findings specifying the circumstances in which innovation occurs, discussing factors such as the intrinsic nature of innovative individuals and the environmental and socio-ecological conditions that promote innovation, such as necessity, opportunity and free resources. We also highlight key controversies, including the relationship between innovation and intelligence, and the notion of innovativeness as an individual-level trait. Finally, we discuss current research methods and suggest some novel approaches that could fruitfully be deployed. © 2016 The Authors.

Animal and human innovation: novel problems and novel solutions

PubMed Central

2016-01-01

This theme issue explores how and why behavioural innovation occurs, and the consequences of innovation for individuals, groups and populations. A vast literature on human innovation exists, from the development of problem-solving in children, to the evolution of technology, to the cultural systems supporting innovation. A more recent development is a growing literature on animal innovation, which has demonstrated links between innovation and personality traits, cognitive traits, neural measures, changing conditions, and the current state of the social and physical environment. Here, we introduce these fields, define key terms and discuss the potential for fruitful exchange between the diverse fields researching innovation. Comparisons of innovation between human and non-human animals provide opportunities, but also pitfalls. We also summarize some key findings specifying the circumstances in which innovation occurs, discussing factors such as the intrinsic nature of innovative individuals and the environmental and socio-ecological conditions that promote innovation, such as necessity, opportunity and free resources. We also highlight key controversies, including the relationship between innovation and intelligence, and the notion of innovativeness as an individual-level trait. Finally, we discuss current research methods and suggest some novel approaches that could fruitfully be deployed. PMID:26926273

Locally acquired Dengue--Key West, Florida, 2009-2010.

PubMed

2010-05-21

Dengue is the most common vector-borne viral disease in the world, causing an estimated 50-100 million infections and 25,000 deaths each year. During 1946-1980, no cases of dengue acquired in the continental United States were reported. Since 1980, a few locally acquired U.S. cases have been confirmed along the Texas-Mexico border, temporally associated with large outbreaks in neighboring Mexican cities. On September 1, 2009, a New York physician notified the Monroe County (Florida) Health Department (MCHD) and the Florida Department of Health (FDOH) of a suspected dengue case in a New York state resident whose only recent travel was to Key West, Florida. CDC confirmed the diagnosis, and a press release was issued to notify the public and Key West physicians of the potential risk for locally acquired dengue infections. In the next 2 weeks, two dengue infections in Key West residents without recent travel were reported and confirmed. Subsequently, enhanced and active surveillance identified 24 more Key West cases during 2009. On April 13, 2010, another Key West dengue case was reported to FDOH, bringing the total to 28. This report describes the first three dengue cases reported in 2009, briefly summarizes the 2010 case, highlights preliminary findings from the ongoing investigation, and outlines measures used to mitigate and control the outbreak. Clinicians should include dengue in the differential diagnosis of acute febrile illnesses in patients who live in or have recently traveled to subtropical areas of the United States or to the tropics.

Engineering issue: Indoor Air Vapor Intrusion Mitigation Approaches

EPA Science Inventory

The US Environmental Protection Agency (EPA) Engineering Issues are a new series of technology transfer documents that summarize the latest available information on selected treatment and site remeediation technologies and related issues. They are designed to help remedial projec...

A Guide for applying a revised version of the PARIHS framework for implementation

PubMed Central

2011-01-01

Background Based on a critical synthesis of literature on use of the Promoting Action on Research Implementation in Health Services (PARIHS) framework, revisions and a companion Guide were developed by a group of researchers independent of the original PARIHS team. The purpose of the Guide is to enhance and optimize efforts of researchers using PARIHS in implementation trials and evaluations. Methods Authors used a planned, structured process to organize and synthesize critiques, discussions, and potential recommendations for refinements of the PARIHS framework arising from a systematic review. Using a templated form, each author independently recorded key components for each reviewed paper; that is, study definitions, perceived strengths/limitations of PARIHS, other observations regarding key issues and recommendations regarding needed refinements. After reaching consensus on these key components, the authors summarized the information and developed the Guide. Results A number of revisions, perceived as consistent with the PARIHS framework's general nature and intent, are proposed. The related Guide is composed of a set of reference tools, provided in Additional files. Its core content is built upon the basic elements of PARIHS and current implementation science. Conclusions We invite researchers using PARIHS for targeted evidence-based practice (EBP) implementations with a strong task-orientation to use this Guide as a companion and to apply the revised framework prospectively and comprehensively. Researchers also are encouraged to evaluate its use relative to perceived strengths and issues. Such evaluations and critical reflections regarding PARIHS and our Guide could thereby promote the framework's continued evolution. PMID:21878092

Transportation key facts 2002 : useful information about transportation in Oregon

DOT National Transportation Integrated Search

2002-01-01

The Oregon Department of Transportation 2002 edition of Key Facts summarizes information related to transportation in Oregon. Key Facts can be used for a variety of planning and budget purposes, and it is intended to provide: : an introduction to tra...

NASA Standard for Models and Simulations: Credibility Assessment Scale

NASA Technical Reports Server (NTRS)

Babula, Maria; Bertch, William J.; Green, Lawrence L.; Hale, Joseph P.; Mosier, Gary E.; Steele, Martin J.; Woods, Jody

2009-01-01

As one of its many responses to the 2003 Space Shuttle Columbia accident, NASA decided to develop a formal standard for models and simulations (M&S). Work commenced in May 2005. An interim version was issued in late 2006. This interim version underwent considerable revision following an extensive Agency-wide review in 2007 along with some additional revisions as a result of the review by the NASA Engineering Management Board (EMB) in the first half of 2008. Issuance of the revised, permanent version, hereafter referred to as the M&S Standard or just the Standard, occurred in July 2008. Bertch, Zang and Steeleiv provided a summary review of the development process of this standard up through the start of the review by the EMB. A thorough recount of the entire development process, major issues, key decisions, and all review processes are available in Ref. v. This is the second of a pair of papers providing a summary of the final version of the Standard. Its focus is the Credibility Assessment Scale, a key feature of the Standard, including an example of its application to a real-world M&S problem for the James Webb Space Telescope. The companion paper summarizes the overall philosophy of the Standard and an overview of the requirements. Verbatim quotes from the Standard are integrated into the text of this paper, and are indicated by quotation marks.

Formalization and separation: A systematic basis for interpreting approaches to summarizing science for climate policy.

PubMed

Sundqvist, Göran; Bohlin, Ingemar; Hermansen, Erlend A T; Yearley, Steven

2015-06-01

In studies of environmental issues, the question of how to establish a productive interplay between science and policy is widely debated, especially in relation to climate change. The aim of this article is to advance this discussion and contribute to a better understanding of how science is summarized for policy purposes by bringing together two academic discussions that usually take place in parallel: the question of how to deal with formalization (structuring the procedures for assessing and summarizing research, e.g. by protocols) and separation (maintaining a boundary between science and policy in processes of synthesizing science for policy). Combining the two dimensions, we draw a diagram onto which different initiatives can be mapped. A high degree of formalization and separation are key components of the canonical image of scientific practice. Influential Science and Technology Studies analysts, however, are well known for their critiques of attempts at separation and formalization. Three examples that summarize research for policy purposes are presented and mapped onto the diagram: the Intergovernmental Panel on Climate Change, the European Union's Science for Environment Policy initiative, and the UK Committee on Climate Change. These examples bring out salient differences concerning how formalization and separation are dealt with. Discussing the space opened up by the diagram, as well as the limitations of the attraction to its endpoints, we argue that policy analyses, including much Science and Technology Studies work, are in need of a more nuanced understanding of the two crucial dimensions of formalization and separation. Accordingly, two analytical claims are presented, concerning trajectories, how organizations represented in the diagram move over time, and mismatches, how organizations fail to handle the two dimensions well in practice.

Site Selection and Deployment Scenarios for Servicing of Deep-Space Observatories

NASA Technical Reports Server (NTRS)

Willenberg, Harvey J.; Fruhwirth, Michael A.; Potter, Seth D.; Leete, Stephen J.; Moe, Rud V.

2001-01-01

The deep-space environment and relative transportation accessibility of the Weak Stability Boundary (WSB) region connecting the Earth-Moon and Sun-Earth libration points makes the Sun-Earth L2 an attractive operating location for future observatories. A summary is presented of key characteristics of future observatories designed to operate in this region. The ability to service observatories that operate within the region around the Lagrange points may greatly enhance their reliability, lifetime, and scientific return. The range of servicing missions might begin with initial deployment, assembly, test, and checkout. Post-assembly servicing missions might also include maintenance and repair, critical fluids resupply, and instrument upgrades. We define the range of servicing missions that can be performed with extravehicular activity, with teleoperated robots, and with autonomous robots. We then describe deployment scenarios that affect payload design. A trade study is summarized of the benefits and risks of alternative servicing sites, including at the International Space Station, at other low-Earth-orbit locations, at the Earth-Moon L1 location, and on-site at the Sun-Earth L2 location. Required technology trades and development issues for observatory servicing at each site, and with each level of autonomy, are summarized.

Plant health and global change--some implications for landscape management.

PubMed

Pautasso, Marco; Dehnen-Schmutz, Katharina; Holdenrieder, Ottmar; Pietravalle, Stéphane; Salama, Nabeil; Jeger, Mike J; Lange, Eckart; Hehl-Lange, Sigrid

2010-11-01

Global change (climate change together with other worldwide anthropogenic processes such as increasing trade, air pollution and urbanization) will affect plant health at the genetic, individual, population and landscape level. Direct effects include ecosystem stress due to natural resources shortage or imbalance. Indirect effects include (i) an increased frequency of natural detrimental phenomena, (ii) an increased pressure due to already present pests and diseases, (iii) the introduction of new invasive species either as a result of an improved suitability of the climatic conditions or as a result of increased trade, and (iv) the human response to global change. In this review, we provide an overview of recent studies on terrestrial plant health in the presence of global change factors. We summarize the links between climate change and some key issues in plant health, including tree mortality, changes in wildfire regimes, biological invasions and the role of genetic diversity for ecosystem resilience. Prediction and management of global change effects are complicated by interactions between globalization, climate and invasive plants and/or pathogens. We summarize practical guidelines for landscape management and draw general conclusions from an expanding body of literature. © 2010 The Authors. Biological Reviews © 2010 Cambridge Philosophical Society.

Children’s Contact With Their Incarcerated Parents

PubMed Central

Poehlmann, Julie; Dallaire, Danielle; Loper, Ann Booker; Shear, Leslie D.

2014-01-01

Approximately 1.7 million children have parents who are incarcerated in prison in the United States, and possibly millions of additional children have a parent incarcerated in jail. Many affected children experience increased risk for developing behavior problems, academic failure, and substance abuse. For a growing number of children, incarcerated parents, caregivers, and professionals, parent– child contact during the imprisonment period is a key issue. In this article, we present a conceptual model to provide a framework within which to interpret findings about parent– child contact when parents are incarcerated. We then summarize recent research examining parent–child contact in context. On the basis of the research reviewed, we present initial recommendations for children’s contact with incarcerated parents and also suggest areas for future intervention and research with this vulnerable population. PMID:20822198

Photocatalytic destruction of chlorinated solvents in water with solar energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pacheco, J.E.; Prairie, M.R.; Yellowhorse, L.

1993-08-01

Sandia National Laboratories and the National Renewable Energy Laboratory are developing a photocatalytic process to destroy organic contaminants in water. Tests with common water pollutants have been conducted at Sandia's Solar Thermal Facility using a near commercial scale, single-axis tracking parabolic trough system with a glass pipe reactor mounted at its focus. Experiments at this scale provide verification of laboratory studies and allow examination of design and operation issues at a real-lifescale. The catalyst, titanium dioxide (TiO[sub 2]), is a harmless material found in paint, cosmetics, and toothpaste. Experiments were conducted to determine the effects of key process parameters onmore » destruction rates of chlorinated organic compounds that are common water pollutants. This paper summarizes the engineering-scale results of these experiments and analyses.« less

The Concept of Magnitude and What It Tells Us About How Struggling Students Learn Fractions.

PubMed

Woodward, John

This commentary summarizes emerging research into fractions instruction for students who are at risk for failure. Each of the three articles emphasizes a measure conception of fractions. Teaching fractions as measurement helps students learn the magnitude of rational numbers. However, measurement is only part of the way that students should conceptualize fractions. Instruction also needs to emphasize fractions as division. The article also draws attention to the teaching qualifications of those who typically instruct at-risk students in Tier 2 and 3 settings. More often than not, these individuals lack the pedagogical content knowledge needed to adapt instruction and address student misconceptions. This is a critical issue going forward as the field attempts to balance procedural understanding with key underlying fractional ideas such a measurement and division.

Research priorities on ending child marriage and supporting married girls.

PubMed

Svanemyr, Joar; Chandra-Mouli, Venkatraman; Raj, Anita; Travers, Ellen; Sundaram, Lakshmi

2015-09-03

Over the past few years the issue of child marriage has received growing political and programmatic attention. In spite of some progress in a number of countries, global rates have not declined over the past decade. Knowledge gaps remain in understanding trends, drivers and approaches to ending child marriage, especially to understand what is needed to achieve results on a large scale. This commentary summarizes the outcomes of an Expert Group Meeting organized by World Health Organization to discuss research priorities on Ending Child Marriage and Supporting Married Girls. It presents research gaps and recommends priorities for research in five key areas; (i) prevalence and trends of child marriage; (ii) causes of child marriage (iii) consequences of child marriage; (iv) efforts to prevent child marriage; (v) efforts to support married girls.

A review on prognostics approaches for remaining useful life of lithium-ion battery

NASA Astrophysics Data System (ADS)

Su, C.; Chen, H. J.

2017-11-01

Lithium-ion (Li-ion) battery is a core component for various industrial systems, including satellite, spacecraft and electric vehicle, etc. The mechanism of performance degradation and remaining useful life (RUL) estimation correlate closely to the operating state and reliability of the aforementioned systems. Furthermore, RUL prediction of Li-ion battery is crucial for the operation scheduling, spare parts management and maintenance decision for such kinds of systems. In recent years, performance degradation prognostics and RUL estimation approaches have become a focus of the research concerning with Li-ion battery. This paper summarizes the approaches used in Li-ion battery RUL estimation. Three categories are classified accordingly, i.e. model-based approach, data-based approach and hybrid approach. The key issues and future trends for battery RUL estimation are also discussed.

Patient privacy in the genomic era.

PubMed

Raisaro, Jean Louis; Ayday, Erman; Hubaux, Jean-Pierre

2014-05-07

According to many scientists and clinicians, genomics is taking on a key role in the field of medicine. Impressive advances in genome sequencing have opened the way to a variety of revolutionary applications in modern healthcare. In particular, the increasing understanding of the human genome, and of its relation to diseases and response to treatments brings promise of improvements in better preventive and personalized medicine. However, this progress raises important privacy and ethical concerns that need to be addressed. Indeed, each genome is the ultimate identifier of its owner and, due to its nature, it contains highly personal and privacy-sensitive data. In this article, after summarizing recent advances in genomics, we discuss some important privacy issues associated with human genomic information and methods put in place to address them.

Space Station needs, attributes and architectural options. Volume 2, book 2, part 3: Communication system

NASA Technical Reports Server (NTRS)

1983-01-01

Preliminary results of the study of the architecture and attributes of the RF communications and tracking subsystem of the space station are summarized. Only communications between the space station and other external elements such as TDRSS satellites, low-orbit spacecraft, OTV, MOTV, in the general environment of the space station are considered. The RF communications subsystem attributes and characteristics are defined and analyzed key issues are identified for evolution from an initial space station (1990) to a year 2000 space station. The mass and power characteristics of the communications subsystem for the initial space station are assessed as well as the impact of advanced technology developments. Changes needed to the second generation TDRSS to accommodate the evolutionary space station of the year 2000 are also identified.

Pathological criteria and practical issues in papillary lesions of the breast - a review.

PubMed

Ni, Yun-Bi; Tse, Gary M

2016-01-01

Papillary lesions of the breast include a broad spectrum of lesions, ranging from benign papilloma, papilloma with atypical ductal hyperplasia (ADH) or ductal carcinoma in situ (DCIS) to papillary carcinoma. The accurate diagnosis of mammary papillary lesions is a challenge for pathologists, owing to the overlapping features among these lesions. In this review, some of the diagnostic criteria of papillary lesions are discussed, with special emphasis on some key morphological features, namely fibrovascular cores, epithelial proliferation in a solid pattern, intraductal papilloma complicated by ADH or DCIS, and invasion and its mimics. The roles of immunohistochemistry, and the interpretation of myoepithelial cell markers, hormone receptors, and high molecular weight cytokeratin, are addressed. Finally, novel biomarkers and genetic aberrations in papillary lesions are summarized. © 2015 John Wiley & Sons Ltd.

Summary on several key techniques in 3D geological modeling.

PubMed

Mei, Gang

2014-01-01

Several key techniques in 3D geological modeling including planar mesh generation, spatial interpolation, and surface intersection are summarized in this paper. Note that these techniques are generic and widely used in various applications but play a key role in 3D geological modeling. There are two essential procedures in 3D geological modeling: the first is the simulation of geological interfaces using geometric surfaces and the second is the building of geological objects by means of various geometric computations such as the intersection of surfaces. Discrete geometric surfaces that represent geological interfaces can be generated by creating planar meshes first and then spatially interpolating; those surfaces intersect and then form volumes that represent three-dimensional geological objects such as rock bodies. In this paper, the most commonly used algorithms of the key techniques in 3D geological modeling are summarized.

Women's roundtable discussion on the economic, social and political impacts of the Southeast Asian financial crisis.

PubMed

Kelkar, G

1998-01-01

This article summarizes the main issues revealed at a women's roundtable discussion on the Economic, Social, and Political Impacts of the Southeast Asian Financial Crisis. The discussion was organized by the Development Alternatives of Women for the New Era (DAWN) and was held during April 12-14, 1998, in Manila, the Philippines. The aim was to explore the effects of the financial crisis and its management by states and multilateral agencies on women's political, economic, cultural, and social status; and to reach regional understanding of new issues for the women's movement in Asia and to identify areas of advocacy. Participants included women scholars and activists from Southeast, East, and South Asia; Africa; the Caribbean; Latin America; and the Pacific. Participants came from a wide variety of backgrounds. Nine issues were emphasized. For example, some predicted the currency devaluation before July 1997. The financial crisis is linked with globalization. The International Monetary Fund (IMF) is the primary institution for addressing the financial crisis. IMF conditions on inflation rates and budget surpluses are recessionary and government budget oriented. The crisis has exposed cronyism and corruption within capitalism. Patriarchal values have reemerged as Asian values. Women have lost jobs and income, while the cost of living continues to increase. Prostitution has become more acceptable as legitimate work. Women's human rights are not legally protected. State ideology assumes domestic and sex roles. Issues in each region are identified. 14 key issues pertain to all regions.

Parent News: A Compilation of 1997 Issues.

ERIC Educational Resources Information Center

Robertson, Anne S., Ed.

1997-01-01

This document consists of the 12 issues of "Parent News" (an electronic Internet magazine for parents, prepared for the National Parent Information Network) published during 1997. Each monthly issue contains feature articles describing the activities of the National Parent Information Network, summarizing research useful to parents,…

Applied Optics Golden Anniversary commemorative reviews: introduction.

PubMed

Mait, Joseph N; Mendez, Eugenio; Peyghambarian, Nasser; Poon, T-C

2013-01-01

Applied Optics presents three special issues to end its retrospective of Applied Optics' 50 years. The special issues are interference, interferometry, and phase; imaging, optical processing, and telecommunications; and polarization and scattering. The issues, which contain 19 commemorative reviews from some of the journal's luminaries, are summarized.

Multimedia Learning: Beyond Modality. Commentary.

ERIC Educational Resources Information Center

Reimann, P.

2003-01-01

Identifies and summarizes instructional messages in the articles in this theme issue and also identifies central theoretical issues, focusing on: (1) external representations; (2) dual coding theory; and (3) the effects of animations on learning. (SLD)

User Acceptance Of Atis Products And Services: A Briefing Book On The Current Status Of Jpo Research

DOT National Transportation Integrated Search

1996-03-01

- TO SUMMARIZE THE ISSUES THAT ARISE IN GAINING A BETTER UNDERSTANDING OF CUSTOMER ACCEPTANCE ("WHY IS IT VITALLY IMPORTANT?" "WHY IS IT A GOVERNMENTAL INTEREST?" "HOW CAN THE INFORMATION BE USED?") : - TO SUMMARIZE THE RESEARCH STRATEGY THAT OUR ...

Myalgic Encephalomyelitis: Symptoms and Biomarkers

PubMed Central

Jasona, Leonard A.; Zinn, Marcie L.; Zinn, Mark A.

2015-01-01

Myalgic Encephalomyelitis (ME) continues to cause significant morbidity worldwide with an estimated one million cases in the United States. Hurdles to establishing consensus to achieve accurate evaluation of patients with ME continue, fueled by poor agreement about case definitions, slow progress in development of standardized diagnostic approaches, and issues surrounding research priorities. Because there are other medical problems, such as early MS and Parkinson’s Disease, which have some similar clinical presentations, it is critical to accurately diagnose ME to make a differential diagnosis. In this article, we explore and summarize advances in the physiological and neurological approaches to understanding, diagnosing, and treating ME. We identify key areas and approaches to elucidate the core and secondary symptom clusters in ME so as to provide some practical suggestions in evaluation of ME for clinicians and researchers. This review, therefore, represents a synthesis of key discussions in the literature, and has important implications for a better understanding of ME, its biological markers, and diagnostic criteria. There is a clear need for more longitudinal studies in this area with larger data sets, which correct for multiple testing. PMID:26411464

Advanced Technology Composite Fuselage: Program Overview

NASA Technical Reports Server (NTRS)

Ilcewicz, L. B.; Smith, P. J.; Hanson, C. T.; Walker, T. H.; Metschan, S. L.; Mabson, G. E.; Wilden, K. S.; Flynn, B. W.; Scholz, D. B.; Polland, D. R.;

International nuclear waste management fact book

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abrahms, C W; Patridge, M D; Widrig, J E

1995-11-01

The International Nuclear Waste Management Fact Book has been compiled to provide current data on fuel cycle and waste management facilities, R and D programs, and key personnel in 24 countries, including the US; four multinational agencies; and 20 nuclear societies. This document, which is in its second year of publication supersedes the previously issued International Nuclear Fuel Cycle Fact Book (PNL-3594), which appeared annually for 12 years. The content has been updated to reflect current information. The Fact Book is organized as follows: National summaries--a section for each country that summarizes nuclear policy, describes organizational relationships, and provides addressesmore » and names of key personnel and information on facilities. International agencies--a section for each of the international agencies that has significant fuel cycle involvement and a list of nuclear societies. Glossary--a list of abbreviations/acronyms of organizations, facilities, and technical and other terms. The national summaries, in addition to the data described above, feature a small map for each country and some general information that is presented from the perspective of the Fact Book user in the US.« less

A Framework for Human Performance Criteria for Advanced Reactor Operational Concepts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacques V Hugo; David I Gertman; Jeffrey C Joe

2014-08-01

This report supports the determination of new Operational Concept models needed in support of the operational design of new reactors. The objective of this research is to establish the technical bases for human performance and human performance criteria frameworks, models, and guidance for operational concepts for advanced reactor designs. The report includes a discussion of operating principles for advanced reactors, the human performance issues and requirements for human performance based upon work domain analysis and current regulatory requirements, and a description of general human performance criteria. The major findings and key observations to date are that there is some operatingmore » experience that informs operational concepts for baseline designs for SFR and HGTRs, with the Experimental Breeder Reactor-II (EBR-II) as a best-case predecessor design. This report summarizes the theoretical and operational foundations for the development of a framework and model for human performance criteria that will influence the development of future Operational Concepts. The report also highlights issues associated with advanced reactor design and clarifies and codifies the identified aspects of technology and operating scenarios.« less

Discussion and Reflection on Several Core Issues in the Grand Canal Heritage Conservation Planning Under the Background of Application for World Heritage

NASA Astrophysics Data System (ADS)

Yao, D.; Dai, D. S.; Tang, Y. Z.; Zhu, G. Y.; Chen, X.

2015-08-01

At the turn of the century, a series of new heritage concepts have appeared in the area of international cultural heritage protection, such as cultural landscape, cultural route, heritage corridor, heritage canal, which presents the development of people's recognition of cultural heritage. According to The Operational Guidelines for the Implementation of the World Heritage Convention, management planning must be contained in the material used to apply for world heritage. The State Administration of Cultural Heritage designed the mission and work schedule of China's Grand Canal conservation planning in 2008. This research will introduce the working system of China's Grand Canal conservation planning on three levels: city, province and nation. It will also summarize the characteristics of the core technologies in China's Grand Canal conservation planning, including key issues like the identification of the core characteristic of China's Grand Canal, value assessment and determination of the protection scope. Through reviewing, thinking and analyzing the previous accomplishments, the research will offer some advices for the similar world heritage conservation planning after.

Statistical issues in reporting quality data: small samples and casemix variation.

PubMed

Zaslavsky, A M

2001-12-01

To present two key statistical issues that arise in analysis and reporting of quality data. Casemix variation is relevant to quality reporting when the units being measured have differing distributions of patient characteristics that also affect the quality outcome. When this is the case, adjustment using stratification or regression may be appropriate. Such adjustments may be controversial when the patient characteristic does not have an obvious relationship to the outcome. Stratified reporting poses problems for sample size and reporting format, but may be useful when casemix effects vary across units. Although there are no absolute standards of reliability, high reliabilities (interunit F > or = 10 or reliability > or = 0.9) are desirable for distinguishing above- and below-average units. When small or unequal sample sizes complicate reporting, precision may be improved using indirect estimation techniques that incorporate auxiliary information, and 'shrinkage' estimation can help to summarize the strength of evidence about units with small samples. With broader understanding of casemix adjustment and methods for analyzing small samples, quality data can be analysed and reported more accurately.

An overview of prevention research: issues, answers, and new agendas.

PubMed Central

Howard, J; Taylor, J A; Ganikos, M L; Holder, H D; Godwin, D F; Taylor, E D

1988-01-01

Efforts to curtail alcohol abuse and alcoholism can be divided into primary, secondary, and tertiary prevention. Primary prevention attempts to stop a problem or illness from occurring in the first place. Secondary prevention identifies persons in the early stages of problematic or illness behavior and refers them for counseling or treatment, which is considered tertiary prevention. Five research areas concerned with primary and secondary prevention are selected for discussion: youth, the mass media, the worksite, blacks and Hispanics, and alcohol-related behavior that increases the risk of AIDS. Several of these themes have been in the forefront of alcohol prevention research; others such as AIDS are emergent areas of injury. The discussion to follow briefly summarizes research approaches, key findings, methodological shortcomings, and suggested issues for future investigation. Although scientifically solid prevention studies have been conducted, more rigorous, more comprehensive, and more innovative research is needed. Given the dynamic sociocultural and economic systems in which prevention occurs, research techniques that can address this complexity are required. A range of appropriate methodologies is described. PMID:3141964

Pharmacogenetics and pharmacogenomics in drug development and regulatory decision making: report of the first FDA-PWG-PhRMA-DruSafe Workshop.

PubMed

Lesko, Lawrence J; Salerno, Ronald A; Spear, Brian B; Anderson, Donald C; Anderson, Timothy; Brazell, Celia; Collins, Jerry; Dorner, Andrew; Essayan, David; Gomez-Mancilla, Baltazar; Hackett, Joseph; Huang, Shiew-Mei; Ide, Susan; Killinger, Joanne; Leighton, John; Mansfield, Elizabeth; Meyer, Robert; Ryan, Stephen G; Schmith, Virginia; Shaw, Peter; Sistare, Frank; Watson, Mark; Worobec, Alexandra

2003-04-01

The use of pharmacogenetics and pharmacogenomics in the drug development process, and in the assessment of such data submitted to regulatory agencies by industry, has generated significant enthusiasm as well as important reservations within the scientific and medical communities. This situation has arisen because of the increasing number of exploratory and confirmatory investigations into variations in RNA expression patterns and DNA sequences being conducted in the preclinical and clinical phases of drug development, and the uncertainty surrounding the acceptance of these data by regulatory agencies. This report summarizes the outcome of a workshop cosponsored by the Food and Drug Administration (FDA), the Pharmacogenetics Working Group (PWG), the Pharmaceutical Research and Manufacturers of America (PhRMA), and the PhRMA Preclinical Safety Committee (DruSafe). The specific aim of the workshop was to identify key issues associated with the application of pharmacogenetics and pharmacogenomics, including the feasibility of a regulatory "safe harbor" for exploratory genome-based data, and to provide a forum for industry-regulatory agency dialogue on these important issues.

Children of Incarcerated Parents.

ERIC Educational Resources Information Center

Simmons, Charlene Wear

2000-01-01

This report summarizes what is known about the children of incarcerated parents in California. The report estimates the number of children in California who have parents in the state's criminal justice system (jail, prison, parole, and probation) and summarizes key findings from the research literature on the impact of parental arrest and…

Human health effects of dichloromethane: key findings and scientific issues.

PubMed

Schlosser, Paul M; Bale, Ambuja S; Gibbons, Catherine F; Wilkins, Amina; Cooper, Glinda S

2015-02-01

The U.S. EPA's Integrated Risk Information System (IRIS) completed an updated toxicological review of dichloromethane in November 2011. In this commentary we summarize key results and issues of this review, including exposure sources, identification of potential health effects, and updated physiologically based pharmacokinetic (PBPK) modeling. We performed a comprehensive review of primary research studies and evaluation of PBPK models. Hepatotoxicity was observed in oral and inhalation exposure studies in several studies in animals; neurological effects were also identified as a potential area of concern. Dichloromethane was classified as likely to be carcinogenic in humans based primarily on evidence of carcinogenicity at two sites (liver and lung) in male and female B6C3F1 mice (inhalation exposure) and at one site (liver) in male B6C3F1 mice (drinking-water exposure). Recent epidemiologic studies of dichloromethane (seven studies of hematopoietic cancers published since 2000) provide additional data raising concerns about associations with non-Hodgkin lymphoma and multiple myeloma. Although there are gaps in the database for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissues in vivo), the positive DNA damage assays correlated with tissue and/or species availability of functional glutathione S-transferase (GST) metabolic activity, the key activation pathway for dichloromethane-induced cancer. Innovations in the IRIS assessment include estimation of cancer risk specifically for a presumed sensitive genotype (GST-theta-1+/+), and PBPK modeling accounting for human physiological distributions based on the expected distribution for all individuals 6 months to 80 years of age. The 2011 IRIS assessment of dichloromethane provides insights into the toxicity of a commonly used solvent.

Key Issues in the Role of Peroxisome Proliferator–Activated Receptor Agonism and Cell Signaling in Trichloroethylene Toxicity

PubMed Central

Keshava, Nagalakshmi; Caldwell, Jane C.

2006-01-01

Peroxisome proliferator–activated receptor α (PPARα) is thought to be involved in several different diseases, toxic responses, and receptor pathways. The U.S. Environmental Protection Agency 2001 draft trichloroethylene (TCE) risk assessment concluded that although PPAR may play a role in liver tumor induction, the role of its activation and the sequence of subsequent events important to tumorigenesis are not well defined, particularly because of uncertainties concerning the extraperoxisomal effects. In this article, which is part of a mini-monograph on key issues in the health risk assessment of TCE, we summarize some of the scientific literature published since that time on the effects and actions of PPARα that help inform and illustrate the key scientific questions relevant to TCE risk assessment. Recent analyses of the role of PPARα in gene expression changes caused by TCE and its metabolites provide only limited data for comparison with other PPARα agonists, particularly given the difficulties in interpreting results involving PPARα knockout mice. Moreover, the increase in data over the last 5 years from the broader literature on PPARα agonists presents a more complex array of extraperoxisomal effects and actions, suggesting the possibility that PPARα may be involved in modes of action (MOAs) not only for liver tumors but also for other effects of TCE and its metabolites. In summary, recent studies support the conclusion that determinations of the human relevance and susceptibility to PPARα-related MOA(s) of TCE-induced effects cannot rely on inferences regarding peroxisome proliferation per se and require a better understanding of the interplay of extraperoxisomal events after PPARα agonism. PMID:16966106

Legal Issues in Teacher Evaluation. Handbook.

ERIC Educational Resources Information Center

Educational Testing Service, Princeton, NJ.

Various legal issues associated with teacher evaluation and significant court decisions are summarized in this handbook. Three major legal issues are defined: (1) failure of the school district to follow due process when terminating tenured and non-tenured teachers, or when abolishing positions; (2) discrimination in employment and promotion, or…

Treatment of the Biracial Child: Theoretical and Clinical Issues.

ERIC Educational Resources Information Center

Brandell, Jerrold R.

1988-01-01

Discusses theoretical and clinical issues that surround the psychotherapeutic treatment of biracial children. Summarizes Heinz Kohut's theory on the development of the self in the biracial child. A case study is included. (BH)

Teacher & Administrator Training in Technology.

ERIC Educational Resources Information Center

Ambron, Sueann, Ed.

1986-01-01

This report summarizes a November 1985 meeting at which members of the Apple Education Advisory Council addressed the issues involved in training teachers and administrators on the best ways to use computers in education. In their discussions, Advisory Council members first summarized the roles that are played by each type of organization involved…

A scoping review of research on complementary and alternative medicine (CAM) and the mass media: looking back, moving forward.

PubMed

Weeks, Laura C; Strudsholm, Tina

2008-07-19

The use of complementary and alternative medicine (CAM) has become more common in Western developed countries in recent years, as has media reporting on CAM and related issues. Correspondingly, media reports are a primary information source regarding decisions to use CAM. Research on CAM related media reports is becoming increasingly relevant and important; however, identifying key concepts to guide future research is problematic due to the dispersed nature of completed research in this field. A scoping review was conducted to: 1) determine the amount, focus and nature of research on CAM and the mass media; and 2) summarize and disseminate related research results. The main phases were: 1) searching for relevant studies; 2) selecting studies based on pre-defined inclusion criteria; 3) extracting data; and 4) collating, summarizing and reporting the results. Of 4,454 studies identified through various search strategies, 16 were relevant to our objectives and included in a final sample. CAM and media research has focused primarily on print media coverage of a range of CAM therapies, although only a few studies articulated differences within the range of therapies surveyed. Research has been developed through a variety of disciplinary perspectives, with a focus on representation research. The research reviewed suggests that journalists draw on a range of sources to prepare media reports, although most commonly they cite conventional (versus CAM) sources and personal anecdotes. The tone of media reports appears generally positive, which may be related to a lack of reporting on issues related to risk and safety. Finally, a variety of discourses within media representations of CAM are apparent that each appeal to a specific audience through resonance with their specific concerns. Research on CAM and the mass media spans multiple disciplines and strategies of inquiry; however, despite the diversity in approach, it is clear that issues related to production and reception of media content are in need of research attention. To address the varied issues in a comprehensive manner, future research needs to be collaborative, involving researchers across disciplines, journalists and CAM users.

A scoping review of research on complementary and alternative medicine (CAM) and the mass media: Looking back, moving forward

PubMed Central

Weeks, Laura C; Strudsholm, Tina

2008-01-01

Background The use of complementary and alternative medicine (CAM) has become more common in Western developed countries in recent years, as has media reporting on CAM and related issues. Correspondingly, media reports are a primary information source regarding decisions to use CAM. Research on CAM related media reports is becoming increasingly relevant and important; however, identifying key concepts to guide future research is problematic due to the dispersed nature of completed research in this field. A scoping review was conducted to: 1) determine the amount, focus and nature of research on CAM and the mass media; and 2) summarize and disseminate related research results. Methods The main phases were: 1) searching for relevant studies; 2) selecting studies based on pre-defined inclusion criteria; 3) extracting data; and 4) collating, summarizing and reporting the results. Results Of 4,454 studies identified through various search strategies, 16 were relevant to our objectives and included in a final sample. CAM and media research has focused primarily on print media coverage of a range of CAM therapies, although only a few studies articulated differences within the range of therapies surveyed. Research has been developed through a variety of disciplinary perspectives, with a focus on representation research. The research reviewed suggests that journalists draw on a range of sources to prepare media reports, although most commonly they cite conventional (versus CAM) sources and personal anecdotes. The tone of media reports appears generally positive, which may be related to a lack of reporting on issues related to risk and safety. Finally, a variety of discourses within media representations of CAM are apparent that each appeal to a specific audience through resonance with their specific concerns. Conclusion Research on CAM and the mass media spans multiple disciplines and strategies of inquiry; however, despite the diversity in approach, it is clear that issues related to production and reception of media content are in need of research attention. To address the varied issues in a comprehensive manner, future research needs to be collaborative, involving researchers across disciplines, journalists and CAM users. PMID:18638413

Summary on Several Key Techniques in 3D Geological Modeling

PubMed Central

2014-01-01

Several key techniques in 3D geological modeling including planar mesh generation, spatial interpolation, and surface intersection are summarized in this paper. Note that these techniques are generic and widely used in various applications but play a key role in 3D geological modeling. There are two essential procedures in 3D geological modeling: the first is the simulation of geological interfaces using geometric surfaces and the second is the building of geological objects by means of various geometric computations such as the intersection of surfaces. Discrete geometric surfaces that represent geological interfaces can be generated by creating planar meshes first and then spatially interpolating; those surfaces intersect and then form volumes that represent three-dimensional geological objects such as rock bodies. In this paper, the most commonly used algorithms of the key techniques in 3D geological modeling are summarized. PMID:24772029

Regulation of stem cell-based therapies in Canada: current issues and concerns.

PubMed

von Tigerstrom, Barbara; Nguyen, Thu Minh; Knoppers, Bartha Maria

2012-09-01

Stem cell therapies offer enormous potential for the treatment of a wide range of diseases and conditions. Despite the excitement over such advances, regulators are faced with the challenge of determining criteria to ensure stem cells and their products are safe and effective for human use. However, stem cell-based products and therapies present unique regulatory challenges because standard drug development models do not wholly apply given the complexity and diversity of these products and therapies. As a result, regulatory requirements are often unclear and ambiguous creating unnecessary barriers for research. In order to better understand the barriers that might affect Canadian stem cell researchers, we sought feedback from stakeholders regarding areas of uncertainty or concern about existing regulatory oversight of cell therapies. A selection of Canadian researchers and clinicians working in the area of stem cell research were interviewed to assess certain key questions: 1) whether current regulatory requirements are easily accessible and well understood; 2) whether regulatory requirements create important challenges or barriers; and 3) whether there is a need for further guidance on the issue. The results of this survey are summarized and compared to issues and concerns experienced in other countries, as reported in the literature, to identify challenges which may be on the horizon and to provide possible solutions for regulatory reform.

Framework for measuring sustainable development in catchment systems.

PubMed

Walmsley, Jay J

2002-02-01

Integrated catchment management represents an approach to managing the resources of a catchment by integrating environmental, economic, and social issues. It is aimed at deriving sustainable benefits for future generations, while protecting natural resources, particularly water, and minimizing possible adverse social, economic, and environmental consequences. Indicators of sustainable development, which summarize information for use in decision-making, are invaluable when trying to assess the diverse, interacting components of catchment processes and resource management actions. The Driving-Forces--Pressure--State--Impact--Response (DPSIR) indicator framework is useful for identifying and developing indicators of sustainable development for catchment management. Driving forces have been identified as the natural conditions occurring in a catchment and the level of development and economic activity. Pressures include the natural and anthropogenic supply of water, water demand, and water pollution. State indicators can be split into those of quantity and those of quality. Impacts include those that affect the ecosystems directly and those that impact the use value of the resource. It core indicators are identified within each of the categories given in the framework, most major catchment-based management issues can be evaluated. This framework is applied to identify key issues in catchment management in South Africa, and develop a set of indicators for evaluating catchments throughout the country.

THE NGA-DOE GRANT TO EXAMINE CRITICAL ISSUES RELATED TO RADIOACTIVE WASTE AND MATERIALS DISPOSITION INVOLVING DOE FACILITIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ann M. Beauchesne

1999-07-30

Through the National Governors' Association (NGA) project ''Critical Issues Related to Radioactive Waste and Materials Disposition Involving DOE Facilities'' NGA brings together Governors' policy advisors, state regulators, and DOE officials to examine critical issues related to the cleanup and operation of DOE nuclear weapons and research facilities. Topics explored through this project include: Decisions involving disposal of mixed, low-level, and transuranic (TRU) waste and disposition of nuclear materials; Decisions involving DOE budget requests and their effect on environmental cleanup and compliance at DOE facilities; Strategies to treat mixed, low-level, and transuranic (TRU) waste and their effect on individual sites inmore » the complex; Changes to the FFCA site treatment plans as a result of proposals in the Department's Accelerating Cleanup: Paths to Closure plan and contractor integration analysis; Interstate waste and materials shipments; and Reforms to existing RCRA and CERCLA regulations/guidance to address regulatory overlap and risks posed by DOE wastes. The overarching theme of this project is to help the Department improve coordination of its major program decisions with Governors' offices and state regulators and to ensure such decisions reflect input from these key state officials and stakeholders. This report summarizes activities conducted during the quarter from May 1, 1999, through July 30, 1999, under the NGA grant. The work accomplished by the NGA project team during the past four months can be categorized as follows: maintained open communication with DOE on a variety of activities and issues within the DOE environmental management complex; maintained communication with NGA Federal Facilities Compliance Task Force members regarding DOE efforts to formulate a configuration for mixed low-level waste and low-level treatment and disposal, external regulation of DOE; and continued to facilitate interactions between the states and DOE to develop a foundation for an ongoing substantive relationship between the Governors of key states and Secretary Richardson.« less

Intelligent transportation systems : tools to maximize state transportation investments

DOT National Transportation Integrated Search

1997-07-28

This Issue Brief summarizes national ITS goals and state transportation needs. It reviews states experience with ITS to date and discusses the utility of ITS technologies to improve transportation infrastructure. The Issue Brief also provides cost...

Transition in Education: Policy Making and the Key Educational Policy Areas in the Central-European and Baltic Countries.

ERIC Educational Resources Information Center

Rado, Peter

This report examines transition in educational systems and identifies key policy areas in Central-Eastern European countries. It summarizes policy implications of the transition process within the educational context of these countries. Chapter 1, "Transition and Education," outlines key characteristics of the transition process and…

Issues in advanced automation for manipulator control

NASA Technical Reports Server (NTRS)

Bejczy, A. K.

1976-01-01

This paper provides a brief description and analysis of the main issues in advanced autonomous control of manipulators as seen from a system point of view. The nature of manipulation is analyzed at some depth. A general multilevel structure is outlined for manipulator control organization which includes the human operator at the top level of the control structure. Different approaches to the development of advanced automation of mechanical arms are summarized. Recent work in the JPL teleoperator project is described, including control system, force/torque sensor, and control software development. Some results from control experiments are summarized.

Campus Climate and Students with Disabilities. NCCSD Research Brief. Volume 1, Issue 2

ERIC Educational Resources Information Center

Harbour, Wendy S.; Greenberg, Daniel

2017-01-01

This research brief summarizes issues related to campus climate issues and disability, to improve social and educational outcomes for students with disabilities, support faculty and staff with disabilities, and increase understanding of disability among nondisabled members of the campus community. Instead of relying on disability services offices…

Top Public Policy Issues for Higher Education in 2013 and 2014

ERIC Educational Resources Information Center

Association of Governing Boards of Universities and Colleges, 2013

2013-01-01

This is the 13th paper in AGB's series summarizing federal and state public policy issues affecting higher education. Governing boards, institutional and university-system leaders, and senior staffs will find it useful for board discussions and retreats and in formulating institutional responses to these issues. The 2015-2016 edition reflects what…

Computer-Based National Information Systems. Technology and Public Policy Issues.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Office of Technology Assessment.

A general introduction to computer based national information systems, and the context and basis for future studies are provided in this report. Chapter One, the introduction, summarizes computers and information systems and their relation to society, the structure of information policy issues, and public policy issues. Chapter Two describes the…

X-ray Emission from Pre-Main-Sequence Stars - Testing the Solar Analogy

NASA Technical Reports Server (NTRS)

Skinner, Stephen L.

2000-01-01

This LTSA award funded my research on the origin of stellar X-ray emission and the validity of the solar-stellar analogy. This research broadly addresses the relevance of our current understanding of solar X-ray physics to the interpretation of X-ray emission from stars in general. During the past five years the emphasis has been on space-based X-ray observations of very young stars in star-forming regions (T Tauri stars and protostars), cool solar-like G stars, and evolved high-mass Wolf-Rayet (WR) stars. These observations were carried out primarily with the ASCA and ROSAT space-based observatories (and most recently with Chandra), supplemented by ground-based observations. This research has focused on the identification of physical processes that are responsible for the high levels of X-ray emission seen in pre-main-sequence (PMS) stars, active cool stars, and WR stars. A related issue is how the X-ray emission of such stars changes over time, both on short timescales of days to years and on evolutionary timescales of millions of years. In the case of the Sun it is known that magnetic fields play a key role in the production of X-rays by confining the coronal plasma in loop-like structures where it is heated to temperatures of several million K. The extent to which the magnetically-confined corona interpretation can be applied to other X-ray emitting stars is the key issue that drives the research summarized here.

Children's contact with their incarcerated parents: research findings and recommendations.

PubMed

Poehlmann, Julie; Dallaire, Danielle; Loper, Ann Booker; Shear, Leslie D

2010-09-01

Approximately 1.7 million children have parents who are incarcerated in prison in the United States, and possibly millions of additional children have a parent incarcerated in jail. Many affected children experience increased risk for developing behavior problems, academic failure, and substance abuse. For a growing number of children, incarcerated parents, caregivers, and professionals, parent-child contact during the imprisonment period is a key issue. In this article, we present a conceptual model to provide a framework within which to interpret findings about parent-child contact when parents are incarcerated. We then summarize recent research examining parent-child contact in context. On the basis of the research reviewed, we present initial recommendations for children's contact with incarcerated parents and also suggest areas for future intervention and research with this vulnerable population. Copyright 2010 APA, all rights reserved.

Symposium on Integrating the Science of Environmental Justice into Decision-Making at the Environmental Protection Agency: An Overview

PubMed Central

Payne-Sturges, Devon; Garcia, Lisa; Lee, Charles; Zenick, Hal; Grevatt, Peter; Sanders, William H.; Case, Heather; Dankwa-Mullan, Irene

2011-01-01

In March 2010, the Environmental Protection Agency (EPA) collaborated with government and nongovernmental organizations to host a groundbreaking symposium, “Strengthening Environmental Justice Research and Decision Making: A Symposium on the Science of Disproportionate Environmental Health Impacts.” The symposium provided a forum for discourse on the state of scientific knowledge about factors identified by EPA that may contribute to higher burdens of environmental exposure or risk in racial/ethnic minorities and low-income populations. Also featured were discussions on how environmental justice considerations may be integrated into EPA's analytical and decision-making frameworks and on research needs for advancing the integration of environmental justice into environmental policymaking. We summarize key discussions and conclusions from the symposium and briefly introduce the articles in this issue. PMID:22028456

Photocatalytic destruction of chlorinated solvents with solar energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pacheco, J.; Prairie, M.; Yellowhorse, L.

1990-01-01

Sandia National Laboratories and the Solar Energy Research Institute are developing a photocatalytic process to destroy organic contaminants in water. Tests with common water pollutants are being conducted at Sandia's Solar Thermal Test Facility using a near commercial-scale single-axis tracking parabolic trough system with glass pipe mounted at its focus. Experiments at this scale provide verification of laboratory studies and allow examination of design and operation issues at a real-life scale. The catalyst, titanium dioxide (TiO{sub 2}), is a harmless material found in paint, cosmetics and toothpaste. Experiments were conducted to determine the effect of key process parameters on destructionmore » rates of two chlorinated organic compounds which are common water pollutants: trichloroethylene and trichloroethane. In this paper, we summarize the engineering-scale results of these experiments and analyses. 21 refs., 8 figs.« less

From upstream to downstream: Megatrends and latest developments in Latin America`s hydrocarbons sector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Kang; Pezeshki, S.; McMahon, J.

1995-08-01

In recent years, Latin America`s hydrocarbons sector has been characterized by reorganization, revitalization, regional cooperation, environmental awakening, and steady expansion. The pattern of these changes, which appear to be the megatrends of the region`s hydrocarbons sector development, will continue during the rest of the 1990s. To further study the current situation and future prospects of Latin America`s hydrocarbons sector, we critically summarize in this short article the key issues in the region`s oil and gas development. These megatrends in Latin America`s hydrocarbons sector development will impact not only the future energy demand and supply in the region, but also globalmore » oil flows in the North American market and across the Pacific Ocean. Each country is individually discussed; pipelines to be constructed are discussed also.« less

Real-space observation of strong metal-support interaction: state-of-the-art and what's the next.

PubMed

Shi, X Y; Zhang, W; Zhang, C; Zheng, W T; Chen, H; Qi, J G

2016-06-01

The real-space resolving of the encapsulated overlayer in the well-known model and industry catalysts, ascribed to the advent of dedicated transmission electron microscopy, enables us to probe novel nano/micro architecture chemistry for better application, revisiting our understanding of this key issue in heterogeneous catalysis. In this review, we summarize the latest progress of real-space observation of SMSI in several well-known systems mainly covered from the metal catalysts (mostly Pt) supported by the TiO2 , CeO2 and Fe3 O4 . As a comparison with the model catalyst Pt/Fe3 O4 , the industrial catalyst Cu/ZnO is also listed, followed with the suggested ongoing directions in the field. © 2015 The Authors Journal of Microscopy © 2015 Royal Microscopical Society.

[Decontamination of organophosphorus compounds: Towards new alternatives].

PubMed

Poirier, L; Jacquet, P; Elias, M; Daudé, D; Chabrière, E

2017-05-01

Organophosphorus coumpounds (OP) are toxic chemicals mainly used for agricultural purpose such as insecticides and were also developed and used as warfare nerve agents. OP are inhibitors of acetylcholinesterase, a key enzyme involved in the regulation of the central nervous system. Chemical, physical and biological approaches have been considered to decontaminate OP. This review summarizes the current and emerging strategies that are investigated to tackle this issue with a special emphasis on enzymatic remediation methods. During the last decade, many studies have been dedicated to the development of biocatalysts for OP removal. Among these, recent reports have pointed out the promising enzyme SsoPox isolated from the archaea Sulfolobus solfataricus. Considering both its intrinsic stability and activity, this hyperthermostable enzyme is highly appealing for the decontamination of OP. Copyright © 2017 Académie Nationale de Pharmacie. All rights reserved.

Ciguatera fish poisoning in la Habana, Cuba: a study of local social-ecological resilience.

PubMed

Morrison, Karen; Aguiar Prieto, Pablo; Castro Domínguez, Arnaldo; Waltner-Toews, David; Fitzgibbon, John

2008-09-01

Following the collapse of the Cuban economy in the early 1990s, epidemiologists in the Cuban Ministry of Health noticed dramatic increases in reported outbreaks of ciguatera fish poisoning (CFP) in some coastal communities. This article summarizes the results of a comparative case study which applied an ecosystem approach to human health to investigate this issue. Situated learning and complexity theories were used to interpret the results of the investigation. CFP outbreaks are influenced by a complex set of interactions between ecological and socioeconomic processes. This study found that the level of organization of the local sports fishing community and the degree of degradation of the local nearshore marine ecosystem appear to be key factors influencing the diverging levels of CFP outbreaks recorded in the 1990s in the communities studied.

The European nanometrology landscape.

PubMed

Leach, Richard K; Boyd, Robert; Burke, Theresa; Danzebrink, Hans-Ulrich; Dirscherl, Kai; Dziomba, Thorsten; Gee, Mark; Koenders, Ludger; Morazzani, Valérie; Pidduck, Allan; Roy, Debdulal; Unger, Wolfgang E S; Yacoot, Andrew

2011-02-11

This review paper summarizes the European nanometrology landscape from a technical perspective. Dimensional and chemical nanometrology are discussed first as they underpin many of the developments in other areas of nanometrology. Applications for the measurement of thin film parameters are followed by two of the most widely relevant families of functional properties: measurement of mechanical and electrical properties at the nanoscale. Nanostructured materials and surfaces, which are seen as key materials areas having specific metrology challenges, are covered next. The final section describes biological nanometrology, which is perhaps the most interdisciplinary applications area, and presents unique challenges. Within each area, a review is provided of current status, the capabilities and limitations of current techniques and instruments, and future directions being driven by emerging industrial measurement requirements. Issues of traceability, standardization, national and international programmes, regulation and skills development will be discussed in a future paper.

Results of the Vapor Compression Distillation Flight Experiment (VCD-FE)

NASA Technical Reports Server (NTRS)

Hutchens, Cindy; Graves, Rex

2004-01-01

Vapor Compression Distillation (VCD) is the chosen technology for urine processing aboard the International Space Station (ISS). Key aspects of the VCD design have been verified and significant improvements made throughout the ground;based development history. However, an important element lacking from previous subsystem development efforts was flight-testing. Consequently, the demonstration and validation of the VCD technology and the investigation of subsystem performance in micro-gravity were the primary goals of the VCD-FE. The Vapor Compression Distillation Flight Experiment (VCD-E) was a flight experiment aboard the Space Shuttle Columbia during the STS-107 mission. The VCD-FE was a full-scale developmental version of the Space Station Urine Processor Assembly (UPA) and was designed to test some of the potential micro-gravity issues with the design. This paper summarizes the experiment results.

Apatinib for the treatment of gastric cancer.

PubMed

Geng, Ruixuan; Li, Jin

2015-01-01

Antiangiogenesis therapy plays an important role in cancer treatment. Apatinib mesylate, a small molecule tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, has been recommended as third-line treatment for metastatic gastric cancer patients. The current review summarizes the publications and conference reports relating to apatinib from preclinical and clinical research in gastric cancer. Apatinib showed good safety, tolerance and treatment efficacy in Phase I/II studies. In a Phase III study, apatinib prolonged the median overall survival of patients with chemotherapy-refractory metastatic gastric cancer by 55 days and the median progression-free survival by 25 days compared with placebo. Apatinib is a new treatment option for advanced gastric cancer. Apatinib is expected to have a broader application when it has been evaluated worldwide. The key issues are to find biomarkers and overcome drug resistance.

The European nanometrology landscape

NASA Astrophysics Data System (ADS)

Leach, Richard K.; Boyd, Robert; Burke, Theresa; Danzebrink, Hans-Ulrich; Dirscherl, Kai; Dziomba, Thorsten; Gee, Mark; Koenders, Ludger; Morazzani, Valérie; Pidduck, Allan; Roy, Debdulal; Unger, Wolfgang E. S.; Yacoot, Andrew

2011-02-01

This review paper summarizes the European nanometrology landscape from a technical perspective. Dimensional and chemical nanometrology are discussed first as they underpin many of the developments in other areas of nanometrology. Applications for the measurement of thin film parameters are followed by two of the most widely relevant families of functional properties: measurement of mechanical and electrical properties at the nanoscale. Nanostructured materials and surfaces, which are seen as key materials areas having specific metrology challenges, are covered next. The final section describes biological nanometrology, which is perhaps the most interdisciplinary applications area, and presents unique challenges. Within each area, a review is provided of current status, the capabilities and limitations of current techniques and instruments, and future directions being driven by emerging industrial measurement requirements. Issues of traceability, standardization, national and international programmes, regulation and skills development will be discussed in a future paper.

Mixed Signals in California: A Mismatch between High Schools and Community Colleges. Policy Alert

ERIC Educational Resources Information Center

National Center for Public Policy and Higher Education, 2008

2008-01-01

"Policy Alert" is a publication series that summarizes important policy findings affecting the future of higher education. This issue is based on an earlier study, "Investigating the Alignment of High School and Community College Assessments in California". The "Policy Alert" summarizes the findings of the study, and…

Training Head Start Coordinators for Workplace Preparedness. NCCU Head Start Monograph, October 1995.

ERIC Educational Resources Information Center

North Carolina Central Univ., Durham.

This monograph summarizes results from academic capstone activities of graduate students and faculty advisors regarding issues consistent with Head Start national priorities and practice needs. The following theses are summarized: (1) "Multicultural Education in Head Start Programs in North Carolina" (S.K. Gant); (2) "The Impact of…

Computerized Adaptive Testing for Effective and Efficient Measurement in Counseling and Education

ERIC Educational Resources Information Center

Weiss, David J.

2004-01-01

Computerized adaptive testing (CAT) is described and compared with conventional tests, and its advantages summarized. Some item response theory concepts used in CAT are summarized and illustrated. The author describes the potential usefulness of CAT in counseling and education and reviews some current issues in the implementation of CAT.

Developing Information Systems for Competitive Intelligence Support.

ERIC Educational Resources Information Center

Hohhof, Bonnie

1994-01-01

Discusses issues connected with developing information systems for competitive intelligence support; defines the elements of an effective competitive information system; and summarizes issues affecting system design and implementation. Highlights include intelligence information; information needs; information sources; decision making; and…

Statistical Issues in Social Allocation Models of Intelligence: A Review and a Response

ERIC Educational Resources Information Center

Light, Richard J.; Smith, Paul V.

1971-01-01

This is a response to Shockley (1971) which summarizes the original Light and Smith work; outlines Shockley's criticisms; responds to the statistical issues; and concludes with the methodological implications of the disagreement. (VW)

ITS logical architecture : volume II, process specifications.

DOT National Transportation Integrated Search

1981-07-01

Author's abstract: This report identifies 24 critical issues related to pedestrian and bicycle facilities and programs, summarizes the state-of-the-art on each issue as it is contained in the published literature, and provides a concise commentary on...

The Wharton Symposium: Facing the Issues.

ERIC Educational Resources Information Center

Sullivan, David M.

1982-01-01

A public relations practitioner reports enthusiastically on his return to the campus for an "intellectually-broadening" public relations symposium. He summarizes critical social and economic issues addressed by distinguished scholars and experienced practitioners. For journal availability, see CS 705 902. (PD)

Telescience testbed pilot program, volume 2: Program results

NASA Technical Reports Server (NTRS)

Leiner, Barry M.

1989-01-01

Space Station Freedom and its associated labs, coupled with the availability of new computing and communications technologies, have the potential for significantly enhancing scientific research. A Telescience Testbed Pilot Program (TTPP), aimed at developing the experience base to deal with issues in the design of the future information system of the Space Station era. The testbeds represented four scientific disciplines (astronomy and astrophysics, earth sciences, life sciences, and microgravity sciences) and studied issues in payload design, operation, and data analysis. This volume, of a 3 volume set, which all contain the results of the TTPP, contains the integrated results. Background is provided of the program and highlights of the program results. The various testbed experiments and the programmatic approach is summarized. The results are summarized on a discipline by discipline basis, highlighting the lessons learned for each discipline. Then the results are integrated across each discipline, summarizing the lessons learned overall.

Major Environmental Issues of the Baltic Sea and Science Based Decision Support Strategies towards an Improved Environmental Status

NASA Astrophysics Data System (ADS)

Humborg, C.

2017-12-01

The Baltic Sea is especially susceptible to multiple human impacts due to its estuarine mixing patterns and long water residence times. Temporally and spatially, it is one of the best investigated marginal seas worldwide allowing for a deep knowledge of natural and human processes forming this unique brackish ecosystem. In this presentation, we shortly summarize the physical, biogeochemical and ecological settings of the Baltic Sea and address major human drivers and pressures threatening its ecosystem. Further, we summarize the scientific and political efforts that led to the formulation of Baltic Sea Action Plan, a milestone for eutrophication management and European environmental governance. Further, we summarize the efforts and societal pitfalls towards an Ecosystem Based Fisheries Management, strategies to decrease loads of environmental pollutants and management of marine biodiversity/habitat issues in the unique Baltic Sea context.

High-energy laser weapons: technology overview

NASA Astrophysics Data System (ADS)

Perram, Glen P.; Marciniak, Michael A.; Goda, Matthew

2004-09-01

High energy laser (HEL) weapons are ready for some of today"s most challenging military applications. For example, the Airborne Laser (ABL) program is designed to defend against Theater Ballistic Missiles in a tactical war scenario. Similarly, the Tactical High Energy Laser (THEL) program is currently testing a laser to defend against rockets and other tactical weapons. The Space Based Laser (SBL), Advanced Tactical Laser (ATL) and Large Aircraft Infrared Countermeasures (LAIRCM) programs promise even greater applications for laser weapons. This technology overview addresses both strategic and tactical roles for HEL weapons on the modern battlefield and examines current technology limited performance of weapon systems components, including various laser device types, beam control systems, atmospheric propagation, and target lethality issues. The characteristics, history, basic hardware, and fundamental performance of chemical lasers, solid state lasers and free electron lasers are summarized and compared. The elements of beam control, including the primary aperture, fast steering mirror, deformable mirrors, wavefront sensors, beacons and illuminators will be discussed with an emphasis on typical and required performance parameters. The effects of diffraction, atmospheric absorption, scattering, turbulence and thermal blooming phenomenon on irradiance at the target are described. Finally, lethality criteria and measures of weapon effectiveness are addressed. The primary purpose of the presentation is to define terminology, establish key performance parameters, and summarize technology capabilities.

Performance measurement in healthcare: part II--state of the science findings by stage of the performance measurement process.

PubMed

Adair, Carol E; Simpson, Elizabeth; Casebeer, Ann L; Birdsell, Judith M; Hayden, Katharine A; Lewis, Steven

2006-07-01

This paper summarizes findings of a comprehensive, systematic review of the peer-reviewed and grey literature on performance measurement according to each stage of the performance measurement process--conceptualization, selection and development, data collection, and reporting and use. It also outlines implications for practice. Six hundred sixty-four articles about organizational performance measurement from the health and business literature were reviewed after systematic searches of the literature, multi-rater relevancy ratings, citation checks and expert author nominations. Key themes were extracted and summarized from the most highly rated papers for each performance measurement stage. Despite a virtually universal consensus on the potential benefits of performance measurement, little evidence currently exists to guide practice in healthcare. Issues in conceptualizing systems include strategic alignment and scope. There are debates on the criteria for selecting measures and on the types and quality of measures. Implementation of data collection and analysis systems is complex and costly, and challenges persist in reporting results, preventing unintended effects and putting findings for improvement into action. There is a need for further development and refinement of performance measures and measurement systems, with a particular focus on strategies to ensure that performance measurement leads to healthcare improvement.

Theory and Experiment on Radiative Shocks

NASA Astrophysics Data System (ADS)

Drake, R. Paul

2005-07-01

The current generation of high-energy-density research facilities has enabled the beginnings of experimental studies of radiation hydrodynamic systems, common in astrophysics but difficult to produce in the laboratory. Radiative shock experiments specifically have been a topic of increasing effort in recent years. Our group and collaborators [1] have emphasized the radiographic observation of structure in radiative shocks. These shocks have been produced on the Omega laser by driving a Be piston through Xenon at velocities above 100 km/s. The talk will summarize these experiments and their results. Interpreting these and other experiments is hampered by the limited range of assumptions used in published theories, and by the limitations in readily available simulation tools. This has motivated an examination of radiative shock theory [2]. The talk will summarize the key issues and present results for specific cases. [ 1 ] Gail Glendinning, Ted Perry, Bruce Remington, Jim Knauer, Tom Boehly, and other members of the NLUF Experimental Astrophysics Team. Publications: Reighard et al., Phys. Rev. Lett. submitted; Leibrandt, et al., Ap J., in press, Reighard et al., IFSA 03 Proceedings, Amer. Nucl. Soc. (2004). [2] Useful discussions with Dmitri Ryutov and Serge Bouquet. Supported by the NNSA programs via DOE Grants DE-FG52-03NA00064 and DE FG53 2005 NA26014

Development of Variable Camber Continuous Trailing Edge Flap for Performance Adaptive Aeroelastic Wing

NASA Technical Reports Server (NTRS)

Nguyen, Nhan; Kaul, Upender; Lebofsky, Sonia; Ting, Eric; Chaparro, Daniel; Urnes, James

2015-01-01

This paper summarizes the recent development of an adaptive aeroelastic wing shaping control technology called variable camber continuous trailing edge flap (VCCTEF). As wing flexibility increases, aeroelastic interactions with aerodynamic forces and moments become an increasingly important consideration in aircraft design and aerodynamic performance. Furthermore, aeroelastic interactions with flight dynamics can result in issues with vehicle stability and control. The initial VCCTEF concept was developed in 2010 by NASA under a NASA Innovation Fund study entitled "Elastically Shaped Future Air Vehicle Concept," which showed that highly flexible wing aerodynamic surfaces can be elastically shaped in-flight by active control of wing twist and bending deflection in order to optimize the spanwise lift distribution for drag reduction. A collaboration between NASA and Boeing Research & Technology was subsequently funded by NASA from 2012 to 2014 to further develop the VCCTEF concept. This paper summarizes some of the key research areas conducted by NASA during the collaboration with Boeing Research and Technology. These research areas include VCCTEF design concepts, aerodynamic analysis of VCCTEF camber shapes, aerodynamic optimization of lift distribution for drag minimization, wind tunnel test results for cruise and high-lift configurations, flutter analysis and suppression control of flexible wing aircraft, and multi-objective flight control for adaptive aeroelastic wing shaping control.

Frontage Roads in Texas: Legal Issues, Operational Issues, and Land Use Distinctions

DOT National Transportation Integrated Search

2000-08-01

This research project investigates frontage roads as an element of limited-access highway design. The discussion in this paper reviews legal statutes affecting public access to roadways, summarizes studies on access-right valuation, and considers a v...

Child Support Report, 1997.

ERIC Educational Resources Information Center

Sharman, Phil, Ed.

1997-01-01

This document consists of the twelve issues of "Child Support Report" newsletter published during 1997. Monthly issues typically explore problems related to child support enforcement, report on federal and state government child support enforcement initiatives, and summarize research related to child support. Editorials and information…

Panel Sessions.

ERIC Educational Resources Information Center

Proceedings of the ASIS Mid-Year Meeting, 1992

1992-01-01

Lists the speakers and summarizes the issues addressed for 12 panel sessions on topics related to networking, including libraries and national networks, federal national resources and energy programs, multimedia issues, telecommuting, remote image serving, accessing the Internet, library automation, scientific information, applications of Z39.50,…

FY 2015 Oregon transportation needs and issues.

DOT National Transportation Integrated Search

2015-01-01

The Oregon Transportation Needs and Issues Survey was first conducted in 1993 and has been done : roughly every two years. The latest survey was completed in the Autumn 2015 (State fiscal year (FY) : 2015). This report summarizes the results of the F...

[Significant Issues in Education - Law.] Inequality in Education, Number 17, June 1974.

ERIC Educational Resources Information Center

Hall, Leon; And Others

This issue of Inequality in Education deviates from the usual format of in-depth discussion of a particular topic to include reports on a variety of significant issues in education-law. Leon Hall summarizes the numerous experiences he has had with Southern desegregated schools and students and relates his conclusions about how desegregation is…

Top Public Policy Issues for Higher Education in 2011 and 2012

ERIC Educational Resources Information Center

Association of Governing Boards of Universities and Colleges, 2011

2011-01-01

This is the 11th paper in AGB's series summarizing federal and state public policy issues affecting higher education. We hope that governing boards, institutional and university-system leaders, and senior staffs will find it useful for board discussions and retreats and in formulating institutional responses to these issues. For the next two…

Education Programs: Major Issues Affecting Postsecondary Education, School-to-Work, and Youth Employment Programs.

ERIC Educational Resources Information Center

General Accounting Office, Washington, DC. Health, Education, and Human Services Div.

This document summarizes major postsecondary education issues and school-to-work and youth employment programs for the Education Task Force of the U.S. Senates's Committee on the Budget, and is based on General Accounting Office (GAO) studies completed during 1990-1997. The discussion of postsecondary education issues centers around five themes:…

PrEP implementation research in Africa: what is new?

PubMed

Cowan, Frances M; Delany-Moretlwe, Sinead; Sanders, Eduard J; Mugo, Nelly R; Guedou, Fernand A; Alary, Michel; Behanzin, Luc; Mugurungi, Owen; Bekker, Linda-Gail

2016-01-01

Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM), transgender women and injection drug users) are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW) are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. In each of the target populations, there are overarching issues related to (i) creating demand for PrEP, (ii) addressing supply-side issues and (iii) providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely to have an important influence. Combining interventions that build self-efficacy, empowerment and social cohesion, with evidence-based individualized adherence support for PrEP, are most likely to be effective. Efficacy of tenfovir-based PrEP is proven but many issues related to implementation remain unclear. Here, we have summarized some of the important implementation questions that need to be assessed as PrEP is rolled out across Africa.

PrEP implementation research in Africa: what is new?

PubMed Central

Cowan, Frances M; Delany-Moretlwe, Sinead; Sanders, Eduard J; Mugo, Nelly R; Guedou, Fernand A; Alary, Michel; Behanzin, Luc; Mugurungi, Owen; Bekker, Linda-Gail

2016-01-01

Introduction Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM), transgender women and injection drug users) are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW) are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. Discussion In each of the target populations, there are overarching issues related to (i) creating demand for PrEP, (ii) addressing supply-side issues and (iii) providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely to have an important influence. Combining interventions that build self-efficacy, empowerment and social cohesion, with evidence-based individualized adherence support for PrEP, are most likely to be effective. Conclusions Efficacy of tenfovir-based PrEP is proven but many issues related to implementation remain unclear. Here, we have summarized some of the important implementation questions that need to be assessed as PrEP is rolled out across Africa. PMID:27760680

Lessons from the Canadian national health information technology plan for the United States: opinions of key Canadian experts.

PubMed

Zimlichman, Eyal; Rozenblum, Ronen; Salzberg, Claudia A; Jang, Yeona; Tamblyn, Melissa; Tamblyn, Robyn; Bates, David W

2012-01-01

To summarize the Canadian health information technology (HIT) policy experience and impart lessons learned to the US as it determines its policy in this area. Qualitative analysis of interviews with identified key stakeholders followed by an electronic survey. We conducted semi-structured interviews with 29 key Canadian HIT policy and opinion leaders and used a grounded theory approach to analyze the results. The informant sample was chosen to provide views from different stakeholder groups including national representatives and regional representatives from three Canadian provinces. Canadian informants believed that much of the current US direction is positive, especially regarding incentives and meaningful use, but that there are key opportunities for the US to emphasize direct engagement with providers, define a clear business case for them, sponsor large scale evaluations to assess HIT impact in a broad array of settings, determine standards but also enable access to resources needed for mid-course corrections of standards when issues are identified, and, finally, leverage implementation of digital imaging systems. Not all stakeholder groups were included, such as providers or patients. In addition, as in all qualitative research, a selection bias could be present due to the relatively small sample size. Based on Canadian experience with HIT policy, stakeholders identified as lessons for the US the need to increase direct engagement with providers and the importance of defining the business case for HIT, which can be achieved through large scale evaluations, and of recognizing and leveraging successes as they emerge.

Summary Letter of Key Requirements for FLM Notification Process

EPA Pesticide Factsheets

Letter from Anna Marie Wood, Director of EPA’s Air Quality Policy Division, to Carol McCoy, Chief of the Air Resources Division of the National Park Service (NPS) summarizing the key requirements for the Federal Land Managers (FLMs) notification process.

Automatic video summarization driven by a spatio-temporal attention model

NASA Astrophysics Data System (ADS)

Barland, R.; Saadane, A.

2008-02-01

According to the literature, automatic video summarization techniques can be classified in two parts, following the output nature: "video skims", which are generated using portions of the original video and "key-frame sets", which correspond to the images, selected from the original video, having a significant semantic content. The difference between these two categories is reduced when we consider automatic procedures. Most of the published approaches are based on the image signal and use either pixel characterization or histogram techniques or image decomposition by blocks. However, few of them integrate properties of the Human Visual System (HVS). In this paper, we propose to extract keyframes for video summarization by studying the variations of salient information between two consecutive frames. For each frame, a saliency map is produced simulating the human visual attention by a bottom-up (signal-dependent) approach. This approach includes three parallel channels for processing three early visual features: intensity, color and temporal contrasts. For each channel, the variations of the salient information between two consecutive frames are computed. These outputs are then combined to produce the global saliency variation which determines the key-frames. Psychophysical experiments have been defined and conducted to analyze the relevance of the proposed key-frame extraction algorithm.

FY 2013 Oregon transportation needs and issues survey.

DOT National Transportation Integrated Search

2013-07-01

The Oregon Transportation Needs and Issues Survey was first conducted in 1993 and has been done roughly every two years. The latest survey was completed in the summer of 2012 (State fiscal year (FY) 2013). This report summarizes the results of the FY...

FY 2011 Oregon transportation needs and issues survey.

DOT National Transportation Integrated Search

2011-01-01

The Oregon Transportation Needs and Issues Survey was first conducted in 1993 and has been done roughly every two years. The latest survey was completed in the summer of 2010 (State fiscal year (FY) 2011). This report summarizes the results of the FY...

Adsorption-based Treatment Systems for Removing Chemical Vapors from Indoor Air

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Engineering Issue Papers (EIPs) are a series of technology transfer documents that summarize the latest information on selected waste treatment and site remediation technologies and related issues. EIPs are designed to help remedial ...

Health Related Legal Issues in Education.

ERIC Educational Resources Information Center

Thomas, Stephen B.

This monograph analyzes health and safety issues in education in terms of relevant constitutional and statutory provisions. Chapter 1, an introduction, summarizes Fourteenth Amendment equal protection and due process clauses and defines "handicapped" under the Rehabilitation Act. State assistance and student eligibility under the…

The Law, the Student, and the Catholic School.

ERIC Educational Resources Information Center

Permuth, Steve; And Others

Providing explanatory information regarding the legal principles and issues affecting Catholic school educators, this handbook summarizes student rights, contractual arrangements, and state and federal requirements as they apply to parochial schools. The legal issues involved in torts of negligence, including establishment and violation of…

Geographically isolated wetlands: What we've learned since SWANCC

EPA Science Inventory

The 2001 SWANCC and 2006 Rapanos US Supreme Court decisions created a need for research on geographically isolated wetlands (GIWs). In 2003, a special issue on isolated wetlands was published in Wetlands. That issue contained fifteen papers that reviewed and summarized the lite...

Selective Mutism: Definition, Issues, and Treatment.

ERIC Educational Resources Information Center

Brigham, Frederick J.; Cole, Jane E.

This paper reviews definitions and issues in selective mutism in children and summarizes results of interventions conducted and published since 1982. Definitions and diagnostic criteria of the American Psychiatric Association's "Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (1994)" and the World Health Organization's…

USSR Space Life Sciences Digest, Issue 26

NASA Technical Reports Server (NTRS)

Stone, Lydia Razran (Editor); Frey, Mary Ann (Editor); Teeter, Ronald (Editor); Garshnek, Victoria (Editor); Rowe, Joseph (Editor)

1990-01-01

This is the twenty-sixth issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 35 journal papers or book chapters published in Russian and of 8 Soviet books. In addition, the proceedings of an Intercosmos conference on space biology and medicine are summarized.

Radiation Dose-Volume Effects in the Larynx and Pharynx

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rancati, Tiziana; Schwarz, Marco; Allen, Aaron M.

2010-03-01

The dose-volume outcome data for RT-associated laryngeal edema, laryngeal dysfunction, and dysphagia, have only recently been addressed, and are summarized. For late dysphagia, a major issue is accurate definition and uncertainty of the relevant anatomical structures. These and other issues are discussed.

40 CFR 1502.20 - Tiering.

Code of Federal Regulations, 2011 CFR

2011-07-01

... review (§ 1508.28). Whenever a broad environmental impact statement has been prepared (such as a program... statement or environmental assessment need only summarize the issues discussed in the broader statement and incorporate discussions from the broader statement by reference and shall concentrate on the issues specific...

40 CFR 1502.20 - Tiering.

Code of Federal Regulations, 2013 CFR

2013-07-01

... review (§ 1508.28). Whenever a broad environmental impact statement has been prepared (such as a program... statement or environmental assessment need only summarize the issues discussed in the broader statement and incorporate discussions from the broader statement by reference and shall concentrate on the issues specific...

40 CFR 1502.20 - Tiering.

Code of Federal Regulations, 2012 CFR

2012-07-01

... review (§ 1508.28). Whenever a broad environmental impact statement has been prepared (such as a program... statement or environmental assessment need only summarize the issues discussed in the broader statement and incorporate discussions from the broader statement by reference and shall concentrate on the issues specific...

40 CFR 1502.20 - Tiering.

Code of Federal Regulations, 2010 CFR

2010-07-01

... review (§ 1508.28). Whenever a broad environmental impact statement has been prepared (such as a program... statement or environmental assessment need only summarize the issues discussed in the broader statement and incorporate discussions from the broader statement by reference and shall concentrate on the issues specific...

40 CFR 1502.20 - Tiering.

Code of Federal Regulations, 2014 CFR

2014-07-01

... review (§ 1508.28). Whenever a broad environmental impact statement has been prepared (such as a program... statement or environmental assessment need only summarize the issues discussed in the broader statement and incorporate discussions from the broader statement by reference and shall concentrate on the issues specific...

Agroforestry programs and issues in the northern Marianas Islands

Treesearch

Anthony Paul Tudela

1993-01-01

Agroforestry is an important land-use in the Commonwealth of the Northern Marianas (CNMI) and provides many benefits. Various agencies are involved in forestry and agroforestry, and their programs are summarized in this paper. Major issues involving agroforestry in the CNMI are also discussed.

Lean burn combustor technology at GE Aircraft Engines

NASA Technical Reports Server (NTRS)

Dodds, Willard J.

1992-01-01

This presentation summarizes progress to date at GE Aircraft Engines in demonstration of a lean combustion system for the High Speed Civil Transport (HSCT). These efforts were supported primarily by NASA contracts, with the exception of initial size and weight estimates and development of advanced diagnostics which were conducted under GE Independent Research and Development projects. Key accomplishments to date are summarized below.

Summary of panel session 3 -- Environmental issues affecting CCT deployment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hausker, K.

1997-12-31

The panelists discussed a variety of environmental issues that affect CCT deployment, and more broadly speaking, power development in general. The issues were both international and domestic in nature. The author summarizes the issues discussed. A summary is also presented which highlights ideas from the panelists that could be characterized as solutions to the demand for improved environmental performance and the surrounding uncertainties. The author offers some personal comments and observations.

Human Systems Integration and Automation Issues in Small Unmanned Aerial Vehicles

NASA Technical Reports Server (NTRS)

McCauley, Michael E.; Matsangas, Panagiotis

2004-01-01

The goal of this report is to identify Human System Integration (HSI) and automation issues that contribute to improved effectiveness and efficiency in the operation of U.S. military Small Unmanned Aerial Vehicles (SUAVs). HSI issues relevant to SUAV operations are reviewed and observations from field trials are summarized. Short-term improvements are suggested research issues are identified and an overview is provided of automation technologies applicable to future SUAV design.

Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

PubMed Central

Imajo, Kento; Yoneda, Masato; Kessoku, Takaomi; Ogawa, Yuji; Maeda, Shin; Sumida, Yoshio; Hyogo, Hideyuki; Eguchi, Yuichiro; Wada, Koichiro; Nakajima, Atsushi

2013-01-01

Research in nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), has been limited by the availability of suitable models for this disease. A number of rodent models have been described in which the relevant liver pathology develops in an appropriate metabolic context. These models are promising tools for researchers investigating one of the key issues of NASH: not so much why steatosis occurs, but what causes the transition from simple steatosis to the inflammatory, progressive fibrosing condition of steatohepatitis. The different rodent models can be classified into two large groups. The first includes models in which the disease is acquired after dietary or pharmacological manipulation, and the second, genetically modified models in which liver disease develops spontaneously. To date, no single rodent model has encompassed the full spectrum of human disease progression, but individual models can imitate particular characteristics of human disease. Therefore, it is important that researchers choose the appropriate rodent models. The purpose of the present review is to discuss the metabolic abnormalities present in the currently available rodent models of NAFLD, summarizing the strengths and weaknesses of the established models and the key findings that have furthered our understanding of the disease’s pathogenesis. PMID:24192824

Combining computer modelling and cardiac imaging to understand right ventricular pump function.

PubMed

Walmsley, John; van Everdingen, Wouter; Cramer, Maarten J; Prinzen, Frits W; Delhaas, Tammo; Lumens, Joost

2017-10-01

Right ventricular (RV) dysfunction is a strong predictor of outcome in heart failure and is a key determinant of exercise capacity. Despite these crucial findings, the RV remains understudied in the clinical, experimental, and computer modelling literature. This review outlines how recent advances in using computer modelling and cardiac imaging synergistically help to understand RV function in health and disease. We begin by highlighting the complexity of interactions that make modelling the RV both challenging and necessary, and then summarize the multiscale modelling approaches used to date to simulate RV pump function in the context of these interactions. We go on to demonstrate how these modelling approaches in combination with cardiac imaging have improved understanding of RV pump function in pulmonary arterial hypertension, arrhythmogenic right ventricular cardiomyopathy, dyssynchronous heart failure and cardiac resynchronization therapy, hypoplastic left heart syndrome, and repaired tetralogy of Fallot. We conclude with a perspective on key issues to be addressed by computational models of the RV in the near future. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.

Bismuth chalcogenide compounds Bi 2 × 3 (X=O, S, Se): Applications in electrochemical energy storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ni, Jiangfeng; Bi, Xuanxuan; Jiang, Yu

2017-04-01

Bismuth chalcogenides Bi2×3 (X=O, S, Se) represent a unique type of materials in diverse polymorphs and configurations. Multiple intrinsic features of Bi2×3 such as narrow bandgap, ion conductivity, and environmental friendliness, have render them attractive materials for a wide array of energy applications. In particular, their rich structural voids and the alloying capability of Bi enable the chalcogenides to be alternative electrodes for energy storage such as hydrogen (H), lithium (Li), sodium (Na) storage and supercapacitors. However, the low conductivity and poor electrochemical cycling are two key challenges for the practical utilization of Bi2×3 electrodes. Great efforts have been devotedmore » to mitigate these challenges and remarkable progresses have been achieved, mainly taking profit of nanotechnology and material compositing engineering. In this short review, we summarize state-of-the-art research advances in the rational design of diverse Bi2×3 electrodes and their electrochemical energy storage performance for H, Li, and Na and supercapacitors. We also highlight the key technical issues at present and provide insights for the future development of bismuth based materials in electrochemical energy storage devices.« less

Extreme Space Weather Events: From Cradle to Grave

NASA Astrophysics Data System (ADS)

Riley, Pete; Baker, Dan; Liu, Ying D.; Verronen, Pekka; Singer, Howard; Güdel, Manuel

2018-02-01

Extreme space weather events, while rare, can have a substantial impact on our technologically-dependent society. And, although such events have only occasionally been observed, through careful analysis of a wealth of space-based and ground-based observations, historical records, and extrapolations from more moderate events, we have developed a basic picture of the components required to produce them. Several key issues, however, remain unresolved. For example, what limits are imposed on the maximum size of such events? What are the likely societal consequences of a so-called "100-year" solar storm? In this review, we summarize our current scientific understanding about extreme space weather events as we follow several examples from the Sun, through the solar corona and inner heliosphere, across the magnetospheric boundary, into the ionosphere and atmosphere, into the Earth's lithosphere, and, finally, its impact on man-made structures and activities, such as spacecraft, GPS signals, radio communication, and the electric power grid. We describe preliminary attempts to provide probabilistic forecasts of extreme space weather phenomena, and we conclude by identifying several key areas that must be addressed if we are better able to understand, and, ultimately, predict extreme space weather events.

Maize Lethal Necrosis (MLN), an Emerging Threat to Maize-Based Food Security in Sub-Saharan Africa.

PubMed

Mahuku, George; Lockhart, Benham E; Wanjala, Bramwel; Jones, Mark W; Kimunye, Janet Njeri; Stewart, Lucy R; Cassone, Bryan J; Sevgan, Subramanian; Nyasani, Johnson O; Kusia, Elizabeth; Kumar, P Lava; Niblett, C L; Kiggundu, Andrew; Asea, Godfrey; Pappu, Hanu R; Wangai, Anne; Prasanna, Boddupalli M; Redinbaugh, Margaret G

2015-07-01

In sub-Saharan Africa, maize is a staple food and key determinant of food security for smallholder farming communities. Pest and disease outbreaks are key constraints to maize productivity. In September 2011, a serious disease outbreak, later diagnosed as maize lethal necrosis (MLN), was reported on maize in Kenya. The disease has since been confirmed in Rwanda and the Democratic Republic of Congo, and similar symptoms have been reported in Tanzania, Uganda, South Sudan, and Ethiopia. In 2012, yield losses of up to 90% resulted in an estimated grain loss of 126,000 metric tons valued at $52 million in Kenya alone. In eastern Africa, MLN was found to result from coinfection of maize with Maize chlorotic mottle virus (MCMV) and Sugarcane mosaic virus (SCMV), although MCMV alone appears to cause significant crop losses. We summarize here the results of collaborative research undertaken to understand the biology and epidemiology of MLN in East Africa and to develop disease management strategies, including identification of MLN-tolerant maize germplasm. We discuss recent progress, identify major issues requiring further research, and discuss the possible next steps for effective management of MLN.

State-of-the-art and outlook for biomimetic materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richman, R.H.; Bond, G.M.; McNaughton, W.P.

1994-11-01

A remarkable diversity of structures and molecular functions has evolved in plants and animals. Many of these natural substances have properties or capabilities that belie their origins in humble, everyday, starting materials. Consequently, there is a growing awareness among scientists and engineers that biological systems can be a valuable source of inspiration for man-made materials. Emphasis in this assessment is on biomimetics; that is, the achievement of unusual materials properties or processes by mimicking novel aspects of biological systems. Five broad areas are selected for detailed investigation: Mimicking of Natural Material Designs; Biomimetic Materials Processing; Artificial Photosynthesis; Biomimetic Molecular Electronics;more » and Biomimetic Catalysis. Each of these topics is examined in terms of current activities and approaches, key aspects, unresolved issues, and implications for the power industry. Finally, the researchers, their organizations, the main thrusts of investigation, achievements, and funding agencies are summarized in tabular form.« less

Lectin engineering, a molecular evolutionary approach to expanding the lectin utilities.

PubMed

Hu, Dan; Tateno, Hiroaki; Hirabayashi, Jun

2015-04-27

In the post genomic era, glycomics--the systematic study of all glycan structures of a given cell or organism--has emerged as an indispensable technology in various fields of biology and medicine. Lectins are regarded as "decipherers of glycans", being useful reagents for their structural analysis, and have been widely used in glycomic studies. However, the inconsistent activity and availability associated with the plant-derived lectins that comprise most of the commercially available lectins, and the limit in the range of glycan structures covered, have necessitated the development of innovative tools via engineering of lectins on existing scaffolds. This review will summarize the current state of the art of lectin engineering and highlight recent technological advances in this field. The key issues associated with the strategy of lectin engineering including selection of template lectin, construction of a mutagenesis library, and high-throughput screening methods are discussed.

MALDI mass spectrometry imaging in rheumatic diseases.

PubMed

Rocha, Beatriz; Cillero-Pastor, Berta; Blanco, Francisco J; Ruiz-Romero, Cristina

2017-07-01

Mass spectrometry imaging (MSI) is a technique used to visualize the spatial distribution of biomolecules such as peptides, proteins, lipids or other organic compounds by their molecular masses. Among the different MSI strategies, MALDI-MSI provides a sensitive and label-free approach for imaging of a wide variety of protein or peptide biomarkers from the surface of tissue sections, being currently used in an increasing number of biomedical applications such as biomarker discovery and tissue classification. In the field of rheumatology, MALDI-MSI has been applied to date for the analysis of joint tissues such as synovial membrane or cartilage. This review summarizes the studies and key achievements obtained using MALDI-MSI to increase understanding on rheumatic pathologies and to describe potential diagnostic or prognostic biomarkers of these diseases. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann. Copyright © 2016 Elsevier B.V. All rights reserved.

Biophysics of α-synuclein membrane interactions.

PubMed

Pfefferkorn, Candace M; Jiang, Zhiping; Lee, Jennifer C

2012-02-01

Membrane proteins participate in nearly all cellular processes; however, because of experimental limitations, their characterization lags far behind that of soluble proteins. Peripheral membrane proteins are particularly challenging to study because of their inherent propensity to adopt multiple and/or transient conformations in solution and upon membrane association. In this review, we summarize useful biophysical techniques for the study of peripheral membrane proteins and their application in the characterization of the membrane interactions of the natively unfolded and Parkinson's disease (PD) related protein, α-synuclein (α-syn). We give particular focus to studies that have led to the current understanding of membrane-bound α-syn structure and the elucidation of specific membrane properties that affect α-syn-membrane binding. Finally, we discuss biophysical evidence supporting a key role for membranes and α-syn in PD pathogenesis. This article is part of a Special Issue entitled: Membrane protein structure and function. Copyright © 2011. Published by Elsevier B.V.

Stem cells, in vitro gametogenesis and male fertility.

PubMed

Nagamatsu, Go; Hayashi, Katsuhiko

2017-12-01

Reconstitution in culture of biological processes, such as differentiation and organization, is a key challenge in regenerative medicine, and one in which stem cell technology plays a central role. Pluripotent stem cells and spermatogonial stem cells are useful materials for reconstitution of germ cell development in vitro , as they are capable of differentiating into gametes. Reconstitution of germ cell development, termed in vitro gametogenesis, will provide an experimental platform for a better understanding of germ cell development, as well as an alternative source of gametes for reproduction, with the potential to cure infertility. Since germ cells are the cells for 'the next generation', both the culture system and its products must be carefully evaluated. In this issue, we summarize the progress in in vitro gametogenesis, most of which has been made using mouse models, as well as the future challenges in this field. © 2017 Society for Reproduction and Fertility.

The Evolution of Gero-Oncology Nursing

PubMed Central

Bond, Stewart M.; Bryant, Ashley Leak; Puts, Martine

2016-01-01

Objectives This article summarizes the evolution of gero-oncology nursing and highlights key educational initiatives, clinical practice issues, and research areas to enhance care of older adults with cancer. Data Sources Peer-reviewed literature, position statements, clinical practice guidelines, web-based materials, and professional organizations’ resources. Conclusion Globally, the older adult cancer population is rapidly growing. The care of older adults with cancer requires an understanding of their diverse needs and the intersection of cancer and aging. Despite efforts to enhance competence in gerooncology and to develop a body of evidence, nurses and healthcare systems remain under-prepared to provide high quality care for older adults with cancer. Implications for Nursing Practice Nurses need to take a leadership role in integrating gerontological principles into oncology settings. Working closely with interdisciplinary team members, nurses should utilize available resources and continue to build evidence through gero-oncology nursing research. PMID:26830263

Reconstructing Folding Energy Landscapes by Single-Molecule Force Spectroscopy

PubMed Central

Woodside, Michael T.; Block, Steven M.

2015-01-01

Folding may be described conceptually in terms of trajectories over a landscape of free energies corresponding to different molecular configurations. In practice, energy landscapes can be difficult to measure. Single-molecule force spectroscopy (SMFS), whereby structural changes are monitored in molecules subjected to controlled forces, has emerged as a powerful tool for probing energy landscapes. We summarize methods for reconstructing landscapes from force spectroscopy measurements under both equilibrium and nonequilibrium conditions. Other complementary, but technically less demanding, methods provide a model-dependent characterization of key features of the landscape. Once reconstructed, energy landscapes can be used to study critical folding parameters, such as the characteristic transition times required for structural changes and the effective diffusion coefficient setting the timescale for motions over the landscape. We also discuss issues that complicate measurement and interpretation, including the possibility of multiple states or pathways and the effects of projecting multiple dimensions onto a single coordinate. PMID:24895850

Physics and Process Modeling (PPM) and Other Propulsion R and T. Volume 1; Materials Processing, Characterization, and Modeling; Lifting Models

NASA Technical Reports Server (NTRS)

1997-01-01

This CP contains the extended abstracts and presentation figures of 36 papers presented at the PPM and Other Propulsion R&T Conference. The focus of the research described in these presentations is on materials and structures technologies that are parts of the various projects within the NASA Aeronautics Propulsion Systems Research and Technology Base Program. These projects include Physics and Process Modeling; Smart, Green Engine; Fast, Quiet Engine; High Temperature Engine Materials Program; and Hybrid Hyperspeed Propulsion. Also presented were research results from the Rotorcraft Systems Program and work supported by the NASA Lewis Director's Discretionary Fund. Authors from NASA Lewis Research Center, industry, and universities conducted research in the following areas: material processing, material characterization, modeling, life, applied life models, design techniques, vibration control, mechanical components, and tribology. Key issues, research accomplishments, and future directions are summarized in this publication.

[Progresses of alpine treeline formation mechanism.

PubMed

Cong, Yu; He, Hong Shi; Gu, Xiao Nan; Xu, Wen Ru; Liu, Kai; Zong, Sheng Wei; Du, Hai Bo

2016-09-01

Alpine treelines represent one of the most distinct vegetation boundaries between canopy closed montane forest and treeless alpine vegetation. This transitional ecotone is highly sensitive to global and regional climate change and is considered as an ideal indicator of such changes. Treeline studies have evolved from morphological description to various hypotheses of treeline formation. Although individual hypothesis may provide reasonable explanation locally, a generalized hypothesis that is applicable on the global scale is still lacking. Temperature is considered the limited factor controlling the distribution of alpine treeline as low temperature restricts biochemical processes of tree growth. However, which particular biochemical processes are affected by low temperature remains unknown. This paper summarized the mechanisms of treeline formation with a focus on how low temperature affects photosynthesis characteristics, nutrient characteristics, non-structural carbohydrate (NSC) and antioxidant system. We also reviewed the key issues and future perspectives in treeline research.

Drugging the undruggable Ras: mission possible?

PubMed Central

Cox, Adrienne D.; Fesik, Stephen W.; Kimmelman, Alec C.; Luo, Ji; Der, Channing J.

2015-01-01

Despite more than three decades of intensive effort, no effective pharmacologic inhibitors of the Ras oncoproteins have reached the clinic, prompting the widely held perception that Ras proteins are “undruggable”. However, there is renewed hope that this is not the case. In this review, we summarize the progress and promise of five key directions. First, we focus on the prospects of direct inhibitors of Ras. Second, we revisit the issue of whether blocking Ras membrane association is a viable approach. Third, we assess the status of targeting Ras downstream effector signalling, arguably the most favourable current direction. Fourth, we address whether the search for synthetic lethal interactors of mutant RAS still holds promise. Finally, Ras-mediated changes in cell metabolism have recently been described. Can these changes be exploited for new therapeutic directions? We conclude with perspectives on how additional complexities, not yet fully understood, may impact each of these approaches. PMID:25323927

Building the Future: Summary of Four Studies to Develop the Private Sector, Education, Health Care, and Data for Decisionmaking for the Kurdistan Region - Iraq (with Arabic-language version).

PubMed

Anthony, C Ross; Hansen, Michael L; Kumar, Krishna B; Shatz, Howard J; Vernez, Georges

2013-01-01

In 2010, the Kurdistan Regional Government (KRG) asked the RAND Corporation to undertake four studies aimed at improving the economic and social development of the Kurdistan Region of Iraq. RAND's work was intended to help the KRG expand access to high-quality education and health care, increase private-sector development and employment for the expanding labor force, and design a data-collection system to support high-priority policies. The studies were carried out over the year beginning February 2010. The RAND teams worked closely with the Ministries of Planning, Education, and Health to develop targeted solutions to the critical issues faced by the KRG. This article summarizes the health care study. It is intended to provide a high-level overview of the approaches, followed by the studies, key findings, and major recommendations.

Life cycle assessment of bioenergy systems: state of the art and future challenges.

PubMed

Cherubini, Francesco; Strømman, Anders Hammer

2011-01-01

The use of different input data, functional units, allocation methods, reference systems and other assumptions complicates comparisons of LCA bioenergy studies. In addition, uncertainties and use of specific local factors for indirect effects (like land-use change and N-based soil emissions) may give rise to wide ranges of final results. In order to investigate how these key issues have been addressed so far, this work performs a review of the recent bioenergy LCA literature. The abundance of studies dealing with the different biomass resources, conversion technologies, products and environmental impact categories is summarized and discussed. Afterwards, a qualitative interpretation of the LCA results is depicted, focusing on energy balance, GHG balance and other impact categories. With the exception of a few studies, most LCAs found a significant net reduction in GHG emissions and fossil energy consumption when bioenergy replaces fossil energy. Copyright © 2010 Elsevier Ltd. All rights reserved.

Using intensive case management to reduce violence by mentally ill persons in the community.

PubMed

Dvoskin, J A; Steadman, H J

1994-07-01

Aggressive and intensive case management and a comprehensive array of community support services are the keys to reducing the risk of violence by people with serious mental illness in the community. The authors describe the elements of intensive case management for potentially violent clients, including use of individual case managers responsible for small caseloads, 24-hour availability of case managers, and strong linkages to agencies providing mental health services, substance abuse treatment, and social services as well as to the criminal justice system. They summarize the results of three recent studies of intensive case management programs suggesting that this intervention is effective in reducing clients' dangerousness in the community. They discuss cultural and human resource issues that affect planning of intensive case management services. Intensive case managers need to be "boundary spanners" with the training, experience, and personality to bridge the often-broad gap between human service and criminal justice systems.

A comparison of production system life cycle models

NASA Astrophysics Data System (ADS)

Attri, Rajesh; Grover, Sandeep

2012-09-01

Companies today need to keep up with the rapidly changing market conditions to stay competitive. The main issues in this paper are related to a company's market and its competitors. The prediction of market behavior is helpful for a manufacturing enterprise to build efficient production systems. However, these predictions are usually not reliable. A production system is required to adapt to changing markets, but such requirement entails higher cost. Hence, analyzing different life cycle models of the production system is necessary. In this paper, different life cycle models of the production system are compared to evaluate the distinctive features and the limitations of each model. Furthermore, the difference between product life cycle and production life cycle is summarized, and the effect of product life cycle on production life cycle is explained. Finally, a production system life cycle model, along with key activities to be performed in each stage, is proposed specifically for the manufacturing sector.

Advances in imaging secondary ion mass spectrometry for biological samples

DOE PAGES

Boxer, Steven G.; Kraft, Mary L.; Weber, Peter K.

2008-12-16

Imaging mass spectrometry combines the power of mass spectrometry to identify complex molecules based on mass with sample imaging. Recent advances in secondary ion mass spectrometry have improved sensitivity and spatial resolution, so that these methods have the potential to bridge between high-resolution structures obtained by X-ray crystallography and cyro-electron microscopy and ultrastructure visualized by conventional light microscopy. Following background information on the method and instrumentation, we address the key issue of sample preparation. Because mass spectrometry is performed in high vacuum, it is essential to preserve the lateral organization of the sample while removing bulk water, and this hasmore » been a major barrier for applications to biological systems. Furthermore, recent applications of imaging mass spectrometry to cell biology, microbial communities, and biosynthetic pathways are summarized briefly, and studies of biological membrane organization are described in greater depth.« less

Challenges and perspectives of garnet solid electrolytes for all solid-state lithium batteries

NASA Astrophysics Data System (ADS)

Liu, Qi; Geng, Zhen; Han, Cuiping; Fu, Yongzhu; Li, Song; He, Yan-bing; Kang, Feiyu; Li, Baohua

2018-06-01

Garnet Li7La3Zr2O12 (LLZO) solid electrolytes recently have attracted tremendous interest as they have the potential to enable all solid-state lithium batteries (ASSLBs) owing to high ionic conductivity (10-3 to 10-4 S cm-1), negligible electronic transport, wide potential window (up to 9 V), and good chemical stability. Here we present the key issues and challenges of LLZO in the aspects of ion conduction property, interfacial compatibility, and stability in air. First, different preparation methods of LLZO are reviewed. Then, recent progress about the improvement of ionic conductivity and interfacial property between LLZO and electrodes are presented. Finally, we list some emerging LLZO-based solid-state batteries and provide perspectives for further research. The aim of this review is to summarize the up-to-date developments of LLZO and lead the direction for future development which could enable LLZO-based ASSLBs.

The impact of biotechnology on agricultural worker safety and health.

PubMed

Shutske, J M; Jenkins, S M

2002-08-01

Biotechnology applications such as the use and production of genetically modified organisms (GMOs) have been widely promoted, adopted, and employed by agricultural producers throughout the world. Yet, little research exists that examines the implications of agricultural biotechnology on the health and safety of workers involved in agricultural production and processing. Regulatory frameworks do exist to examine key issues related to food safety and environmental protection in GMO applications. However, based on the lack of research and regulatory oversight, it would appear that the potential impact on the safety and health of workers is of limited interest. This article examines some of the known worker health and safety implications related to the use and production of GMOs using the host, agent, and environment framework. The characteristics of employers, workers, inputs, production practices, and socio-economic environments in which future agricultural workers perform various tasks is likely to change based on the research summarized here.

The Evolution of Gero-Oncology Nursing.

PubMed

Bond, Stewart M; Bryant, Ashley Leak; Puts, Martine

2016-02-01

This article summarizes the evolution of gero-oncology nursing and highlights key educational initiatives, clinical practice issues, and research areas to enhance care of older adults with cancer. Peer-reviewed literature, position statements, clinical practice guidelines, Web-based materials, and professional organizations' resources. Globally, the older adult cancer population is rapidly growing. The care of older adults with cancer requires an understanding of their diverse needs and the intersection of cancer and aging. Despite efforts to enhance competence in gero-oncology and to develop a body of evidence, nurses and health care systems remain under-prepared to provide high-quality care for older adults with cancer. Nurses must take a leadership role in integrating gerontological principles into oncology settings. Working closely with interdisciplinary team members, nurses should utilize available resources and continue to build evidence through gero-oncology nursing research. Copyright © 2016 Elsevier Inc. All rights reserved.

Whole-Brain Microscopy Meets In Vivo Neuroimaging: Techniques, Benefits, and Limitations.

PubMed

Aswendt, Markus; Schwarz, Martin; Abdelmoula, Walid M; Dijkstra, Jouke; Dedeurwaerdere, Stefanie

2017-02-01

Magnetic resonance imaging, positron emission tomography, and optical imaging have emerged as key tools to understand brain function and neurological disorders in preclinical mouse models. They offer the unique advantage of monitoring individual structural and functional changes over time. What remained unsolved until recently was to generate whole-brain microscopy data which can be correlated to the 3D in vivo neuroimaging data. Conventional histological sections are inappropriate especially for neuronal tracing or the unbiased screening for molecular targets through the whole brain. As part of the European Society for Molecular Imaging (ESMI) meeting 2016 in Utrecht, the Netherlands, we addressed this issue in the Molecular Neuroimaging study group meeting. Presentations covered new brain clearing methods, light sheet microscopes for large samples, and automatic registration of microscopy to in vivo imaging data. In this article, we summarize the discussion; give an overview of the novel techniques; and discuss the practical needs, benefits, and limitations.

Low Energy Accelerators for Cargo Inspection

NASA Astrophysics Data System (ADS)

Tang, Chuanxiang

Cargo inspection by X-rays has become essential for seaports and airports. With the emphasis on homeland security issues, the identification of dangerous things, such as explosive items and nuclear materials, is the key feature of a cargo inspection system. And new technologies based on dual energy X-rays, neutrons and monoenergetic X-rays have been studied to achieve sufficiently good material identification. An interpretation of the principle of X-ray cargo inspection technology and the features of X-ray sources are presented in this article. As most of the X-ray sources are based on RF electron linear accelerators (linacs), we give a relatively detailed description of the principle and characteristics of linacs. Cargo inspection technologies based on neutron imaging, neutron analysis, nuclear resonance fluorescence and computer tomography are also mentioned here. The main vendors and their products are summarized at the end of the article.

Does the internet change how we die and mourn? Overview and analysis.

PubMed

Walter, Tony; Hourizi, Rachid; Moncur, Wendy; Pitsillides, Stacey

The article outlines the issues that the internet presents to death studies. Part 1 describes a range of online practices that may affect dying, the funeral, grief and memorialization, inheritance and archaeology; it also summarizes the kinds of research that have been done in these fields. Part 2 argues that these new online practices have implications for, and may be illuminated by, key concepts in death studies: the sequestration (or separation from everyday life) of death and dying, disenfranchisement of grief, private grief, social death, illness and grief narratives, continuing bonds with the dead, and the presence of the dead in society. In particular, social network sites can bring dying and grieving out of both the private and public realms and into the everyday life of social networks beyond the immediate family, and provide an audience for once private communications with the dead.

Progress toward implementation of human papillomavirus vaccination--the Americas, 2006-2010.

PubMed

2011-10-14

Cervical cancer is a major cause of morbidity and mortality in the Americas, where an estimated 80,574 new cases and 36,058 deaths were reported in 2008, with 85% of this burden occurring in Latin America and the Caribbean. Two oncogenic human papillomavirus (HPV) types (16 and 18) cause approximately 70% of cervical cancers and a substantial proportion of other HPV-related cancers. HPV vaccination provides an opportunity to greatly reduce cervical cancer burden through primary prevention of HPV infection. This report summarizes the progress toward HPV vaccine introduction in the Americas, focusing on countries that have introduced the vaccine in national or regional immunization programs. As of January 2011, four countries in the Americas had introduced HPV vaccine. Overcoming issues related to financing and delivery of HPV vaccine remains a key public health challenge to more widespread implementation of HPV vaccination in the Americas.

Children and Families in Urban Schools and Communities Roundtable (Philadelphia, Pennsylvania, November 30-December 1, 2000). Fathers and Families Second-Tier Roundtable Series.

ERIC Educational Resources Information Center

Pennsylvania Univ., Philadelphia. National Center on Fathers and Families.

This paper summarizes a roundtable that brought together researchers, school leaders, practitioners, and policymakers to identify barriers to the education and well-being of urban children and families and explore opportunities to promote change. The first section summarizes the three commissioned papers: "Issues and Strategies Related to…

Modeling and simulation: A key to future defense technology

NASA Technical Reports Server (NTRS)

Muccio, Anthony B.

1993-01-01

The purpose of this paper is to express the rationale for continued technological and scientific development of the modeling and simulation process for the defense industry. The defense industry, along with a variety of other industries, is currently being forced into making sacrifices in response to the current economic hardships. These sacrifices, which may not compromise the safety of our nation, nor jeopardize our current standing as the world peace officer, must be concentrated in areas which will withstand the needs of the changing world. Therefore, the need for cost effective alternatives of defense issues must be examined. This paper provides support that the modeling and simulation process is an economically feasible process which will ensure our nation's safety as well as provide and keep up with the future technological developments and demands required by the defense industry. The outline of this paper is as follows: introduction, which defines and describes the modeling and simulation process; discussion, which details the purpose and benefits of modeling and simulation and provides specific examples of how the process has been successful; and conclusion, which summarizes the specifics of modeling and simulation of defense issues and lends the support for its continued use in the defense arena.

Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank

PubMed Central

Ramirez-Zamora, Adolfo; Giordano, James J.; Gunduz, Aysegul; Brown, Peter; Sanchez, Justin C.; Foote, Kelly D.; Almeida, Leonardo; Starr, Philip A.; Bronte-Stewart, Helen M.; Hu, Wei; McIntyre, Cameron; Goodman, Wayne; Kumsa, Doe; Grill, Warren M.; Walker, Harrison C.; Johnson, Matthew D.; Vitek, Jerrold L.; Greene, David; Rizzuto, Daniel S.; Song, Dong; Berger, Theodore W.; Hampson, Robert E.; Deadwyler, Sam A.; Hochberg, Leigh R.; Schiff, Nicholas D.; Stypulkowski, Paul; Worrell, Greg; Tiruvadi, Vineet; Mayberg, Helen S.; Jimenez-Shahed, Joohi; Nanda, Pranav; Sheth, Sameer A.; Gross, Robert E.; Lempka, Scott F.; Li, Luming; Deeb, Wissam; Okun, Michael S.

2018-01-01

The annual Deep Brain Stimulation (DBS) Think Tank provides a focal opportunity for a multidisciplinary ensemble of experts in the field of neuromodulation to discuss advancements and forthcoming opportunities and challenges in the field. The proceedings of the fifth Think Tank summarize progress in neuromodulation neurotechnology and techniques for the treatment of a range of neuropsychiatric conditions including Parkinson's disease, dystonia, essential tremor, Tourette syndrome, obsessive compulsive disorder, epilepsy and cognitive, and motor disorders. Each section of this overview of the meeting provides insight to the critical elements of discussion, current challenges, and identified future directions of scientific and technological development and application. The report addresses key issues in developing, and emphasizes major innovations that have occurred during the past year. Specifically, this year's meeting focused on technical developments in DBS, design considerations for DBS electrodes, improved sensors, neuronal signal processing, advancements in development and uses of responsive DBS (closed-loop systems), updates on National Institutes of Health and DARPA DBS programs of the BRAIN initiative, and neuroethical and policy issues arising in and from DBS research and applications in practice. PMID:29416498

VOLATILE ORGANIC COMPOUNDS (VOC) RECOVERY ...

EPA Pesticide Factsheets

The purpose of the seminar was to bring researchers, technology developers, and industry representatives together to discuss recovery technologies and techniques for VOCs. The seminar focused on the specific VOC recovery needs of industry and on case studies that summarize effective VOC product recovery techniques applicable to air, water, and solid waste. The case studies highlighted examples in which existing and new recovery technologies resulted in significant cost savings to industry. The seminar focused on the following key issues:. Status and future direction of EPA< DOE, and other major research programs.. What are the latest technology innovations in VOC treatment and recovery?. Performance and cost effectiveness of VOC recovery techniques.. How are recovery techniques applied to air, water, and solid waste?Presenters were from industry, academia, EPA, and various consulting firms. The presentations were followed by several facilitated breakout sessions; these sessions allowed participants an opportunity to discuss their needs and opinions on VOC recovery trends, research, and other issues.This document contains summaries of the presentations and discussions during the seminar. It does not constitute an actual proceedings, since the presentations were informal and no written versions were required. The list of participants and contact information are included in Appendix A. Information

Natural product-based nanomedicine: recent advances and issues

PubMed Central

Watkins, Rebekah; Wu, Ling; Zhang, Chenming; Davis, Richey M; Xu, Bin

2015-01-01

Natural products have been used in medicine for many years. Many top-selling pharmaceuticals are natural compounds or their derivatives. These plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. However, their success in clinical trials has been less impressive, partly due to the compounds’ low bioavailability. The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products both in vitro and in vivo. Nanotechnology has demonstrated its capability to manipulate particles in order to target specific areas of the body and control the release of drugs. Although there are many benefits to applying nanotechnology for better delivery of natural products, it is not without issues. Drug targeting remains a challenge and potential nanoparticle toxicity needs to be further investigated, especially if these systems are to be used to treat chronic human diseases. This review aims to summarize recent progress in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications. PMID:26451111

Intellectual Disability Policy as Developed, Expressed, and Evaluated in AAIDD/The Arc Joint Statements: The Role of Organization Position Statements.

PubMed

Luckasson, Ruth; Ford, Marty E; McMillan, Elise D; Misilo, Frederick M; Nygren, Margaret A

2017-07-01

The American Association on Intellectual and Developmental Disabilities (AAIDD) and The Arc of the United States (The Arc) have a long history of joined efforts to develop, express, and evaluate disability policies. These efforts have resulted in a series of formal statements on critical issues such as education, healthcare, human rights, and criminal justice. Their joint efforts further important policy goals including providing clear strong communication about important policy values and directions, promulgating key principles of high quality supports and services, affirming best professional practices, and emphasizing personal outcomes. In addition, the joint efforts (a) affirm important aspects of organization identity; (b) enhance the organizations' abilities to assure the input of a wide variety of perspectives; (c) engage members' expanded ranges of experiences and talents; (d) multiply staff and leadership resources; (e) increase communication strength and avenues; and (f) establish processes for timely review and revision of policies as critical disability issues arise or change, and new opportunities for policy integration and advancement occur. This article describes the processes used to develop, express, and evaluate the position statements; summarizes the policy content of several joint statements; and discusses the role of these organization position statements.

Current issues in ALS epidemiology: Variation of ALS occurrence between populations and physical activity as a risk factor.

PubMed

Luna, J; Logroscino, G; Couratier, P; Marin, B

2017-05-01

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with a fatal outcome. This review aims to report key epidemiological features of ALS in relation to the hypothesis of variation between populations, to summarize environmental hypothesis and to highlight current issues that deserve much considerations. Epidemiological ALS studies have shown a variation of incidence, mortality and prevalence between geographical areas and different populations. These data could support the notion that genetic factors, especially populations' ancestries, along with environmental and lifestyle factors, play a significant role in the occurrence of the disease. To date, there is no strong evidence to confirm an association between a particular environmental factor and ALS. Physical activity (PA) has been extensively evaluated. Recent studies support with the best evidence level that PA in general population is not a risk factor for ALS. However, further research is needed to clarify the association of PA in some occupations and some athletic activities. Epidemiological research based on multicenter international collaboration is essential to provide new data on ALS especially in some regions of the world that are to date poorly represented in the ALS literature. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Assessing the value of transgenic crops.

PubMed

Lacey, Hugh

2002-10-01

In the current controversy about the value of transgenic crops, matters open to empirical inquiry are centrally at issue. One such matter is a key premise in a common argument (that I summarize) that transgenic crops should be considered to have universal value. The premise is that there are no alternative forms of agriculture available to enable the production of sufficient food to feed the world. The proponents of agroecology challenge it, claiming that agroecology provides an alternative, and they deny the claim that it is well founded on empirical evidence. It is, therefore, a matter of both social and scientific importance that this premise and the criticisms of it be investigated rigorously and empirically, so that the benefits and disadvantages of transgenic-intensive agriculture and agroecology can be compared in a reliable way. Conducting adequate investigation about the potential contribution of agroecology requires that the cultural conditions of its practice (and, thus, of the practices and movements of small-scale farmers in the "third world") be strengthened--and this puts the interests of investigation into tension with the socio-economic interests driving the development of transgenics. General issues about relationship between ethical argument and empirical (scientific) investigation are raised throughout the article.

Human flesh search: a supplemental review.

PubMed

Chao, Chian-Hsueng; Tao, Yu-Hui

2012-07-01

Human flesh search (HFS), a phenomenon that has recently emerged over the Internet, represents the interaction between the virtual and real worlds. The term "HFS" is equivalent to "cyber manhunt" in the West, although there were more large-scale HFS events reported in the East recently. While the majority of academic articles on HFS have focused on the Chinese context, the phenomenon has also been reported in many countries and involves diverse issues such as the controversy between privacy violation and public opinion. Based on 16 HFS references, a review paper by Chen and Sharma summarizes core issues on growth, incidents, distinctive attributes, key benefits and drawbacks, findings, and research gaps and opportunities. Echoing their call for a global HFS context, the current article provides a Taiwanese HFS context based on 32 reported incidents in Taiwan. To conduct an incremental HFS review, this study expands the reference base to 33 carefully selected academic articles from China and Taiwan. The review findings range from 6 derived HFS perspectives supplementing each article, 12 frequently mentioned HFS concepts, and 4 additional research directions. The resulting comprehensive knowledge of HFS, along with that contributed by Chen and Sharma, can be considered a useful reference framework for future HFS studies and policy making.

Deep space telecommunications, navigation, and information management. Support of the space exploration initiative

NASA Astrophysics Data System (ADS)

Hall, Justin R.; Hastrup, Rolf C.

The United States Space Exploration Initiative (SEI) calls for the charting of a new and evolving manned course to the Moon, Mars, and beyond. This paper discusses key challenges in providing effective deep space telecommunications, navigation, and information management (TNIM) architectures and designs for Mars exploration support. The fundamental objectives are to provide the mission with means to monitor and control mission elements, acquire engineering, science, and navigation data, compute state vectors and navigate, and move these data efficiently and automatically between mission nodes for timely analysis and decision-making. Although these objectives do not depart, fundamentally, from those evolved over the past 30 years in supporting deep space robotic exploration, there are several new issues. This paper focuses on summarizing new requirements, identifying related issues and challenges, responding with concepts and strategies which are enabling, and, finally, describing candidate architectures, and driving technologies. The design challenges include the attainment of: 1) manageable interfaces in a large distributed system, 2) highly unattended operations for in-situ Mars telecommunications and navigation functions, 3) robust connectivity for manned and robotic links, 4) information management for efficient and reliable interchange of data between mission nodes, and 5) an adequate Mars-Earth data rate.

Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank.

PubMed

Ramirez-Zamora, Adolfo; Giordano, James J; Gunduz, Aysegul; Brown, Peter; Sanchez, Justin C; Foote, Kelly D; Almeida, Leonardo; Starr, Philip A; Bronte-Stewart, Helen M; Hu, Wei; McIntyre, Cameron; Goodman, Wayne; Kumsa, Doe; Grill, Warren M; Walker, Harrison C; Johnson, Matthew D; Vitek, Jerrold L; Greene, David; Rizzuto, Daniel S; Song, Dong; Berger, Theodore W; Hampson, Robert E; Deadwyler, Sam A; Hochberg, Leigh R; Schiff, Nicholas D; Stypulkowski, Paul; Worrell, Greg; Tiruvadi, Vineet; Mayberg, Helen S; Jimenez-Shahed, Joohi; Nanda, Pranav; Sheth, Sameer A; Gross, Robert E; Lempka, Scott F; Li, Luming; Deeb, Wissam; Okun, Michael S

2017-01-01

The annual Deep Brain Stimulation (DBS) Think Tank provides a focal opportunity for a multidisciplinary ensemble of experts in the field of neuromodulation to discuss advancements and forthcoming opportunities and challenges in the field. The proceedings of the fifth Think Tank summarize progress in neuromodulation neurotechnology and techniques for the treatment of a range of neuropsychiatric conditions including Parkinson's disease, dystonia, essential tremor, Tourette syndrome, obsessive compulsive disorder, epilepsy and cognitive, and motor disorders. Each section of this overview of the meeting provides insight to the critical elements of discussion, current challenges, and identified future directions of scientific and technological development and application. The report addresses key issues in developing, and emphasizes major innovations that have occurred during the past year. Specifically, this year's meeting focused on technical developments in DBS, design considerations for DBS electrodes, improved sensors, neuronal signal processing, advancements in development and uses of responsive DBS (closed-loop systems), updates on National Institutes of Health and DARPA DBS programs of the BRAIN initiative, and neuroethical and policy issues arising in and from DBS research and applications in practice.

Micromachined Fluid Inertial Sensors

PubMed Central

Liu, Shiqiang; Zhu, Rong

2017-01-01

Micromachined fluid inertial sensors are an important class of inertial sensors, which mainly includes thermal accelerometers and fluid gyroscopes, which have now been developed since the end of the last century for about 20 years. Compared with conventional silicon or quartz inertial sensors, the fluid inertial sensors use a fluid instead of a solid proof mass as the moving and sensitive element, and thus offer advantages of simple structures, low cost, high shock resistance, and large measurement ranges while the sensitivity and bandwidth are not competitive. Many studies and various designs have been reported in the past two decades. This review firstly introduces the working principles of fluid inertial sensors, followed by the relevant research developments. The micromachined thermal accelerometers based on thermal convection have developed maturely and become commercialized. However, the micromachined fluid gyroscopes, which are based on jet flow or thermal flow, are less mature. The key issues and technologies of the thermal accelerometers, mainly including bandwidth, temperature compensation, monolithic integration of tri-axis accelerometers and strategies for high production yields are also summarized and discussed. For the micromachined fluid gyroscopes, improving integration and sensitivity, reducing thermal errors and cross coupling errors are the issues of most concern. PMID:28216569

Control of fraud and abuse in Medicare and Medicaid.

PubMed

Pies, H E

1977-01-01

This Comment explores issues concerning the control of fraud and abuse in health programs financed with public funds, specifically the Medicare and Medicaid programs. It summarizes the nature, scope, and possible causes of what some regard as a fraud and abuse "crisis," and points out the difficulties and obstacles facing those who attempt to develop legislative and executive action aimed at controlling fraud and abuse. Recent federal initiatives in fraud and abuse control are examined, and a brief summary of key provisions of H.R. 3 (the Medicare-Medicaid Anti-fraud and Abuse Amendments, which may prove to be a landmark piece of legislation in this area) is provided. The author emphasizes that more effective control of fraud and abuse is necessary if further expansion of government financing of health programs, including national health insurance, is to occur in the near future. At the same time, caution must be taken not to neglect the appropriate use of other mechanisms necessary for reducing the costs of medical care and improving its quality. In addition, it is likely that efforts to stem fraud and abuse will raise important medicolegal and public policy issues that will require careful interdisciplinary consideration.

Cat swarm optimization based evolutionary framework for multi document summarization

NASA Astrophysics Data System (ADS)

Rautray, Rasmita; Balabantaray, Rakesh Chandra

2017-07-01

Today, World Wide Web has brought us enormous quantity of on-line information. As a result, extracting relevant information from massive data has become a challenging issue. In recent past text summarization is recognized as one of the solution to extract useful information from vast amount documents. Based on number of documents considered for summarization, it is categorized as single document or multi document summarization. Rather than single document, multi document summarization is more challenging for the researchers to find accurate summary from multiple documents. Hence in this study, a novel Cat Swarm Optimization (CSO) based multi document summarizer is proposed to address the problem of multi document summarization. The proposed CSO based model is also compared with two other nature inspired based summarizer such as Harmony Search (HS) based summarizer and Particle Swarm Optimization (PSO) based summarizer. With respect to the benchmark Document Understanding Conference (DUC) datasets, the performance of all algorithms are compared in terms of different evaluation metrics such as ROUGE score, F score, sensitivity, positive predicate value, summary accuracy, inter sentence similarity and readability metric to validate non-redundancy, cohesiveness and readability of the summary respectively. The experimental analysis clearly reveals that the proposed approach outperforms the other summarizers included in the study.

The biomarker-based diagnosis of Alzheimer's disease. 1-ethical and societal issues.

PubMed

Porteri, Corinna; Albanese, Emiliano; Scerri, Charles; Carrillo, Maria C; Snyder, Heather M; Martensson, Birgitta; Baker, Mark; Giacobini, Ezio; Boccardi, Marina; Winblad, Bengt; Frisoni, Giovanni B; Hurst, Samia

2017-04-01

There is great interest in the use of biomarkers to assist in the timely identification of Alzheimer's disease (AD) in individuals with mild symptoms. However, the inclusion of AD biomarkers in clinical criteria poses socioethical challenges. The Geneva Task Force for the Roadmap of Alzheimer's Biomarkers was established to deliver a systematic strategic research agenda (aka roadmap) to promote efficient and effective validation of AD biomarkers and to foster their uptake in clinical practice. In this article, we summarize the workshop discussion of the Geneva Task Force "ethical and societal issues" working group, which comprised bioethicists, clinicians, health economists, and representatives of those affected by AD. The working group identified the following key issues that need to be included in the roadmap: improving access to services through timely diagnosis, the need for a diagnostic research protocol before moving to clinical routine, recruitment in diagnostic research protocols in the absence of effective therapy, respect for the autonomy of the individual with mild cognitive impairment in information and consent process and the right not to know biomarkers results, need for counseling programs, disclosure of the diagnosis in a structured environment and the involvement of family members, health policies including the individuals' views and the protection of their interests, and the economic costs for society. Copyright © 2016 Elsevier Inc. All rights reserved.

THE NGA-DOE GRANT TO EXAMINE CRITICAL ISSUES RELATED TO RADIOACTIVE WASTE AND MATERIALS DISPOSITION INVOLVING DOE FACILITIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ethan W. Brown

2001-09-01

Through the National Governors' Association (NGA) project ''Critical Issues Related to Radioactive Waste and Materials Disposition Involving DOE Facilities'' NGA brings together Governors' policy advisors, state regulators, and DOE officials to examine critical issues related to the cleanup and operation of DOE nuclear weapons and research facilities. Topics explored through this project include: Decisions involving disposal of mixed, low-level, and transuranic (TRU) waste and disposition of nuclear materials. Decisions involving DOE budget requests and their effect on environmental cleanup and compliance at DOE facilities. Strategies to treat mixed, low-level, and transuranic (TRU) waste and their effect on individual sites inmore » the complex. Changes to the FFCA site treatment plans as a result of proposals in the Department's Accelerating Cleanup: Paths to Closure plan and contractor integration analysis. Interstate waste and materials shipments. Reforms to existing RCRA and CERCLA regulations/guidance to address regulatory overlap and risks posed by DOE wastes. The overarching theme of this project is to help the Department improve coordination of its major program decisions with Governors' offices and state regulators and to ensure such decisions reflect input from these key state officials and stakeholders. This report summarizes activities conducted during the period from April 1, 2001 through June 30, 2001, under the NGA grant.« less

Changing the Discourse on "Race" and Special Educational Needs.

ERIC Educational Resources Information Center

Diniz, Fernando Almeida; Usmani, Khushi

2001-01-01

Describes attempts to influence the current discourse on special educational needs in Scotland from an antiracist perspective. Maps the national context, issues, and changing circumstances, then summarizes evidence on the issue presented to the Scottish Parliament. Discusses various research and development projects being undertaken to promote…

Australia's IT&T Future: A Strategic Analysis Report 1 July 1998.

ERIC Educational Resources Information Center

Australian Library Journal, 1998

1998-01-01

Summarizes the GartnerGroup's views on issues in the information technology and telecommunications (IT&T) industry debate in Australia. Topics include attracting overseas investment to create a globally competitive industry; the government's role; perceived problems; the Internet and electronic commerce; and future issues, including…

Psychological Testing and Psychological Assessment: A Review of Evidence and Issues.

ERIC Educational Resources Information Center

Meyer, Gregory J.; Finn, Stephen E.; Eyde, Lorraine D.; Kay, Gary G.; Moreland, Kevin L.; Dies, Robert R.; Eisman, Elena J.; Kubiszyn, Tom W.; Reed, Geoffrey M.

2001-01-01

Summarizes issues associated with psychological assessment, concluding that: psychological test validity is strong and is comparable to medical test validity; distinct assessment methods provide unique sources of information; and clinicians who rely solely on interviews are prone to incomplete understandings. Suggests that multimethod assessment…

FY 2017 Oregon transportation needs and issues survey : summary of statewide results.

DOT National Transportation Integrated Search

2017-12-01

The Oregon Transportation Needs and Issues Survey was first conducted in 1993 and has been done roughly every two years. The latest survey was completed in Autumn 2016 (State fiscal year (FY) 2017). This report summarizes the results of the FY 2017 s...

AIDS and HIV Training and Education in Criminal Justice Agencies. AIDS Bulletin.

ERIC Educational Resources Information Center

Hammett, Theodore M.

This bulletin summarizes key elements of an effective AIDS training and education program for law enforcement and corrections personnel. First, these key elements of training and education for criminal justice personnel are discussed: staff participation in materials development; timely and frequent training; mandatory training; live training by…

Using Key Performance Indicators to Drive Strategic Decision Making.

ERIC Educational Resources Information Center

Dolence, Michael G.; Norris, Donald M.

1994-01-01

A nine-step method for defining and pursuing key performance indicators (KPIs), derived from a strategic planning process, is outlined, and its applications at the University of Northern Colorado and Illinois Benedictine College are described and tabulated. A chart summarizes current and projected KPIs for Illinois Benedictine College for each…

Climate change effects on central New Mexico's land use, transportation system and key natural resources : task 1.1 memo.

DOT National Transportation Integrated Search

2014-12-01

This report summarizes potential climate change effects on the availability of water, land use, transportation infrastructure, and key natural resources in central New Mexico. This work is being done as part of the Interagency Transportation, Land Us...

Methane emissions from oceans, coasts, and freshwater habitats: New perspectives and feedbacks on climate

USGS Publications Warehouse

Hamdan, Leila J.; Wickland, Kimberly P.

2016-01-01

Methane is a powerful greenhouse gas, and atmospheric concentrations have risen 2.5 times since the beginning of the Industrial age. While much of this increase is attributed to anthropogenic sources, natural sources, which contribute between 35% and 50% of global methane emissions, are thought to have a role in the atmospheric methane increase, in part due to human influences. Methane emissions from many natural sources are sensitive to climate, and positive feedbacks from climate change and cultural eutrophication may promote increased emissions to the atmosphere. These natural sources include aquatic environments such as wetlands, freshwater lakes, streams and rivers, and estuarine, coastal, and marine systems. Furthermore, there are significant marine sediment stores of methane in the form of clathrates that are vulnerable to mobilization and release to the atmosphere from climate feedbacks, and subsurface thermogenic gas which in exceptional cases may be released following accidents and disasters (North Sea blowout and Deepwater Horizon Spill respectively). Understanding of natural sources, key processes, and controls on emission is continually evolving as new measurement and modeling capabilities develop, and different sources and processes are revealed. This special issue of Limnology and Oceanography gathers together diverse studies on methane production, consumption, and emissions from freshwater, estuarine, and marine systems, and provides a broad view of the current science on methane dynamics of aquatic ecosystems. Here, we provide a general overview of aquatic methane sources, their contribution to the global methane budget, and key uncertainties. We then briefly summarize the contributions to and highlights of this special issue.

An unsupervised method for summarizing egocentric sport videos

NASA Astrophysics Data System (ADS)

Habibi Aghdam, Hamed; Jahani Heravi, Elnaz; Puig, Domenec

2015-12-01

People are getting more interested to record their sport activities using head-worn or hand-held cameras. This type of videos which is called egocentric sport videos has different motion and appearance patterns compared with life-logging videos. While a life-logging video can be defined in terms of well-defined human-object interactions, notwithstanding, it is not trivial to describe egocentric sport videos using well-defined activities. For this reason, summarizing egocentric sport videos based on human-object interaction might fail to produce meaningful results. In this paper, we propose an unsupervised method for summarizing egocentric videos by identifying the key-frames of the video. Our method utilizes both appearance and motion information and it automatically finds the number of the key-frames. Our blind user study on the new dataset collected from YouTube shows that in 93:5% cases, the users choose the proposed method as their first video summary choice. In addition, our method is within the top 2 choices of the users in 99% of studies.

Dating Violence among College Students: Key Issues for College Counselors

ERIC Educational Resources Information Center

Murray, Christine E.; Kardatzke, Kerrie N.

2007-01-01

The authors present a review of literature examining dating violence among college students. They describe 6 key issues related to dating violence among college students that affect college counselors' work. These key issues relate to the incidence and prevalence of physical, sexual, and psychological violence in college students' dating…

Heterogeneity image patch index and its application to consumer video summarization.

PubMed

Dang, Chinh T; Radha, Hayder

2014-06-01

Automatic video summarization is indispensable for fast browsing and efficient management of large video libraries. In this paper, we introduce an image feature that we refer to as heterogeneity image patch (HIP) index. The proposed HIP index provides a new entropy-based measure of the heterogeneity of patches within any picture. By evaluating this index for every frame in a video sequence, we generate a HIP curve for that sequence. We exploit the HIP curve in solving two categories of video summarization applications: key frame extraction and dynamic video skimming. Under the key frame extraction frame-work, a set of candidate key frames is selected from abundant video frames based on the HIP curve. Then, a proposed patch-based image dissimilarity measure is used to create affinity matrix of these candidates. Finally, a set of key frames is extracted from the affinity matrix using a min–max based algorithm. Under video skimming, we propose a method to measure the distance between a video and its skimmed representation. The video skimming problem is then mapped into an optimization framework and solved by minimizing a HIP-based distance for a set of extracted excerpts. The HIP framework is pixel-based and does not require semantic information or complex camera motion estimation. Our simulation results are based on experiments performed on consumer videos and are compared with state-of-the-art methods. It is shown that the HIP approach outperforms other leading methods, while maintaining low complexity.

Environmental availability of chlorinated organics, explosives, and metals in soils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, W.C.; Loehr, R.C.; Smith, B.P.

1999-08-01

Environmental availability is key to defining the extent of remediation required. Nationally recognized experts summarize what is known about the environmental availability of chlorinated organics (Perry McCarty), explosives (Judith Pennington), and metals (Rufus Chaney). It also summarizes the current use of environmental availability to set cleanup goals for petroleum hydrocarbons and identifies essential research needed to expand the knowledge base for environmental availability.

Top Public Policy Issues for Higher Education: 2015-2016

ERIC Educational Resources Information Center

Association of Governing Boards of Universities and Colleges, 2015

2015-01-01

This is the 13th paper in the Association of Governing Boards (AGB's) series summarizing federal and state public policy issues affecting higher education. Governing boards, institutional and university-system leaders, and senior staffs will find it useful for board discussions and retreats and in formulating institutional responses to these…

Assessing Faculty Publication Productivity: Issues of Equity. ERIC Digest.

ERIC Educational Resources Information Center

Creamer, Elizabeth G.

This digest summarizes a report of a study of the research literature on faculty publication productivity, with special emphasis on gender as a factor in publishing productivity. Major issues addressed by the report include: (1) the existence of significant gender and race differences in publishing productivity, with women and minorities…

Adolescent Health Issues: State Actions 1992-1994.

ERIC Educational Resources Information Center

Savage, Melissa Hough

This publication summarizes approximately 300 laws and resolutions concerning adolescent health and related issues passed by the 50 states, and U.S. commonwealths and territories between 1992 and 1994. The state legislation reflects the health problems that, on the whole, involve preventable behavior. Brief descriptions of laws are provided…

Adolescent Health Issues: State Actions 1995.

ERIC Educational Resources Information Center

Savage, Melissa Hough; Ourada, Joanne

Many adolescents need basic health care and other services that address risky behaviors such as sexual activity, violence, alcohol and other drug abuse, and the consequences of those behaviors. This publication summarizes approximately 250 laws and resolutions concerning adolescent health and related issues passed by the 50 states and the District…

Adolescent Health Issues: State Actions 1997.

ERIC Educational Resources Information Center

Kendell, Nicole

Many adolescents need basic health care and other services that address risky behaviors such as sexual activity, violence, alcohol and drug abuse, and the consequences of these behaviors. This publication summarizes laws and resolutions on adolescent health issues passed in 1997 state and territory legislative sessions. No 1997 legislative session…

The Perspectives of Policy Researchers: A Synthesis of Special Issue Contributions

ERIC Educational Resources Information Center

Mullin, Christopher M.

2015-01-01

This article summarizes the divergent perspectives found across the 14 articles written by individuals from three types of policy research organizations--think tanks, regional collaborative organizations, and university-based institutes and centers--for this special issue of the "Community College Journal of Research and Practice." It…

FY 2009 Oregon Transportation Needs and Issues Survey : Summary of Statewide Results

DOT National Transportation Integrated Search

2009-12-01

The Oregon Transportation Needs and Issues Survey was first conducted in 1993 and has been done roughly every two years. The latest survey was completed in the fall of 2008 (State fiscal year (FY) 2009). This report summarizes the results of the FY 2...

Summary of current issues regarding space flight habitability.

PubMed

Novak, J B

2000-09-01

One of the implicit, yet often under-emphasized qualities of human tended spaceflight is the habitability of the spacecraft and mission. This document summarizes some of the points that characterize the current status of this topic. In addition, the summary concludes with goals for future development for this issue.

SPECIAL ISSUE VETERINARY IMMUNOLOGY IMMUNOPATHOLOGY: PROCEEDINGS 8TH INTERNATIONAL VETERINARY IMMUNOLOGY SYMPOSIUM

USDA-ARS?s Scientific Manuscript database

This is the Special Issue of Vet. Immunol. Immunopathol. that summarizes the 8th International Veterinary Immunology Symposium (8 th IVIS) held August 15th-19th, 2007, in Ouro Preto, Brazil. The 8 th IVIS highlighted the importance of veterinary immunology for animal health, vaccinology, reproducti...

Educating Homeless Children: Issues and Answers. Fastback 313.

ERIC Educational Resources Information Center

Stronge, James H.; Tenhouse, Cheri

This publication summarizes issues relating to the education of homeless children and youth and reviews programs that are effective in the delivery of educational services to this population. The report is comprised of five sections. The first section, "Introduction," surveys factors contributing to homelessness and indicates the special…

Advanced control techniques for teleoperation in earth orbit

NASA Technical Reports Server (NTRS)

Bejczy, A. K.; Brooks, T. L.

1980-01-01

Emerging teleoperation tasks in space invite advancements in teleoperator control technology. This paper briefly summarizes the generic issues related to earth orbital applications of teleoperators, and describes teleoperator control technology development work including visual and non-visual sensors and displays, kinesthetic feedback and computer-aided controls. Performance experiments were carried out using sensor and computer aided controls with promising results which are briefly summarized.

Aging barriers influencing mobile health usability for older adults: A literature based framework (MOLD-US).

PubMed

Wildenbos, G A; Peute, Linda; Jaspers, Monique

2018-06-01

With the growing population of older adults as a potential user group of mHealth, the need increases for mHealth interventions to address specific aging characteristics of older adults. The existence of aging barriers to computer use is widely acknowledged. Yet, usability studies show that mHealth still fails to be appropriately designed for older adults and their expectations. To enhance designs of mHealth aimed at older adult populations, it is essential to gain insight into aging barriers that impact the usability of mHealth as experienced by these adults. This study aims to synthesize literature on aging barriers to digital (health) computer use, and explain, map and visualize these barriers in relation to the usability of mHealth by means of a framework. We performed a scoping review to synthesize and summarize reported physical and functional age barriers in relation to digital (mobile) health applications use. Aging barriers reported in the literature were mapped onto usability aspects categorized by Nielsen to explain their influence on user experience of mHealth. A framework (MOLD-US) was developed summarizing the evidence on the influence of aging barriers on mHealth use experienced by older adults. Four key categories of aging barriers influencing usability of mHealth were identified: cognition, motivation, physical ability and perception. Effective and satisfactory use of mHealth by older adults is complicated by cognition and motivation barriers. Physical ability and perceptual barriers further increase the risk of user errors and fail to notice important interaction tasks. Complexities of medical conditions, such as diminished eye sight related to diabetes or deteriorated motor skills as a result of rheumatism, can cause errors in user interaction. This research provides a novel framework for the exploration of aging barriers and their causes influencing mHealth usability in older adults. This framework allows for further systematic empirical testing and analysis of mHealth usability issues, as it enables results to be classified and interpreted based on impediments intrinsic to usability issues experienced by older adults. Importantly, the paper identifies a key need for future research on motivational barriers impeding mhealth use of older adults. More insights are needed in particular to disaggregating normal age related functional changes from specific medical conditions that influence experienced usefulness of mHealth by these adults. Copyright © 2018 Elsevier B.V. All rights reserved.

Stakeholder views on pharmacogenomic testing.

PubMed

Patel, Haridarshan N; Ursan, Iulia D; Zueger, Patrick M; Cavallari, Larisa H; Pickard, A Simon

2014-02-01

Pharmacogenomics has an important role in the evolution of personalized medicine, and its widespread uptake may ultimately depend on the interests and perspectives of key players in health care. Our aim was to summarize studies on stakeholder perspectives and attitudes toward pharmacogenomic testing. Thus, we conducted a review of original research studies that reported stakeholder views on pharmacogenomic testing using a structured approach in PubMed, International Pharmaceutical Abstracts, Cumulative Index to Nursing and Allied Health Literature, and EMBASE. A standardized data abstraction form was developed that included stakeholder group of interest-patients, general public, providers, and payers. Stakeholder views regarding barriers to pharmacogenetic implementation were organized into the following themes: ancillary information-related, clinical, economic, educational, ethical or legal, medical mistrust, and practicality. Of 34 studies that met our inclusion criteria, 37 perspectives were reported (15 on providers, 9 on the general public, 9 on patients, and 4 on payers). The most common topics that arose in studies of providers related to clinical usefulness of genetic data (n=11) and educational needs (n=11). Among the general public, the most common concerns were medical mistrust (n=5), insufficient education (n=5), and practicality (n=5). The most prevalent issues from the patient perspective were ethical or legal (n=6) and economic (n=5) issues. Among payers, leading issues were practicality (n=4) and clinical usefulness (n=3). There was overlap in the topics and concerns across stakeholder perspectives, including lack of knowledge about pharmacogenomic testing. Views on issues related to privacy, cost, and test result dissemination varied by stakeholder perspective. Limited research had been conducted in underrepresented groups. Efforts to address the issues raised by stakeholders may facilitate the implementation of pharmacogenomic testing into clinical practice. © 2013 American College of Clinical Pharmacy.

A coherent graph-based semantic clustering and summarization approach for biomedical literature and a new summarization evaluation method.

PubMed

Yoo, Illhoi; Hu, Xiaohua; Song, Il-Yeol

2007-11-27

A huge amount of biomedical textual information has been produced and collected in MEDLINE for decades. In order to easily utilize biomedical information in the free text, document clustering and text summarization together are used as a solution for text information overload problem. In this paper, we introduce a coherent graph-based semantic clustering and summarization approach for biomedical literature. Our extensive experimental results show the approach shows 45% cluster quality improvement and 72% clustering reliability improvement, in terms of misclassification index, over Bisecting K-means as a leading document clustering approach. In addition, our approach provides concise but rich text summary in key concepts and sentences. Our coherent biomedical literature clustering and summarization approach that takes advantage of ontology-enriched graphical representations significantly improves the quality of document clusters and understandability of documents through summaries.

A coherent graph-based semantic clustering and summarization approach for biomedical literature and a new summarization evaluation method

PubMed Central

Yoo, Illhoi; Hu, Xiaohua; Song, Il-Yeol

2007-01-01

Background A huge amount of biomedical textual information has been produced and collected in MEDLINE for decades. In order to easily utilize biomedical information in the free text, document clustering and text summarization together are used as a solution for text information overload problem. In this paper, we introduce a coherent graph-based semantic clustering and summarization approach for biomedical literature. Results Our extensive experimental results show the approach shows 45% cluster quality improvement and 72% clustering reliability improvement, in terms of misclassification index, over Bisecting K-means as a leading document clustering approach. In addition, our approach provides concise but rich text summary in key concepts and sentences. Conclusion Our coherent biomedical literature clustering and summarization approach that takes advantage of ontology-enriched graphical representations significantly improves the quality of document clusters and understandability of documents through summaries. PMID:18047705

THE NGA-DOE GRANT TO EXAMINE CRITICAL ISSUES RELATED TO RADIOACTIVE WASTE AND MATERIALS DISPOSITION INVOLVING DOE FACILITIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ann M. Beauchesne

2000-01-01

Through the National Governors Association (NGA) project ``Critical Issues Related to Radioactive Waste and Materials Disposition Involving DOE Facilities'' NGA brings together Governors' policy advisors, state regulators, and DOE officials to examine critical issues related to the cleanup and operation of DOE nuclear weapons and research facilities. Topics explored through this project include: Decisions involving disposal of mixed, low-level, and transuranic (TRU) waste and disposition of nuclear materials; Decisions involving DOE budget requests and their effect on environmental cleanup and compliance at DOE facilities; Strategies to treat mixed, low-level, and transuranic (TRU) waste and their effect on individual sites inmore » the complex; Changes to the FFCA site treatment plans as a result of proposals in the Department's Accelerating Cleanup: Paths to Closure plan and contractor integration analysis; Interstate waste and materials shipments; and Reforms to existing RCRA and CERCLA regulations/guidance to address regulatory overlap and risks posed by DOE wastes. The overarching theme of this project is to help the Department improve coordination of its major program decisions with Governors' offices and state regulators and to ensure such decisions reflect input from these key state officials and stakeholders. This report summarizes activities conducted during the period from October 1, 1999 through January 31, 2000, under the NGA grant. The work accomplished by the NGA project team during the past three months can be categorized as follows: maintained open communication with DOE on a variety of activities and issues within the DOE environmental management complex; convened and facilitated the October 6--8 NGA FFCA Task Force Meeting in Oak Ridge, Tennessee; maintained communication with NGA Federal Facilities Compliance Task Force members regarding DOE efforts to formulate a configuration for mixed low-level waste and low-level treatment and disposal, external regulation of DOE; and continued to facilitate interactions between the states and DOE to develop a foundation for an ongoing substantive relationship between the Governors of key states and the Department.« less

Issues in Rural Primary Education in Europe: A Summary of a Symposium on Issues in Rural Education at the European Conference on Educational Research (Seville, Spain, September 25-29, 1996).

ERIC Educational Resources Information Center

Hargreaves, Linda M.

This paper summarizes a symposium on issues in rural education held at the 1996 European Conference on Educational Research held in Seville, Spain. The symposium aimed to gather contextual information about rural primary schools and included presentations from researchers in Sweden, Finland, Scotland, Ireland, and Greece. Participants from the…

The Biswell symposium: fire issues and solutions in urban interface and wildland ecosystems; February 15-17, 1994; Walnut Creek, California

Treesearch

David R. Weise; Robert E. Martin

1995-01-01

These proceedings summarize the results of a symposium designed to address current issues about wildfire and prescribed fire in both the wildland-urban interface and in wildlands. Thirty-eight invited oral papers and 23 poster papers describing the issues and state-of-the-art solutions to technical, biological, and social challenges currently facing land and fire...

Teacher and Administrator Training, Recruitment and Retention. INAR/NACIE Joint Issues Sessions National Indian Education Assocation (NIEA) Annual Conference (22nd, San Diego, California, October 15, 1990).

ERIC Educational Resources Information Center

National Advisory Council on Indian Education, Washington, DC.

This report summarizes two joint sessions held by the Indian Nations At Risk Task Force and the National Advisory Council on Indian Education to hear testimony on Native American issues in educator training and employment. Issues and problems related to recruitment of Native Americans into teacher education include raised admission standards, more…

Teaching Matters: How State and Local Policymakers Can Improve the Quality of Teachers and Teaching. CPRE Policy Briefs RB-48

ERIC Educational Resources Information Center

Corcoran, Thomas B.

2007-01-01

This issue of CPRE Policy Briefs summarizes the findings on issues related to teacher quality in the chapter authored by Thomas B. Corcoran in the book, "The State of Education Policy Research." The report also draws on discussions that took place during a 2006 policy briefing on teacher labor-market issues held in Chicago and sponsored by the…

Women in the US Army. An Annotated Bibliography

DTIC Science & Technology

2002-05-13

females (Mottern et al, 1997). The study focused on six issues : (1) entry-level physical condition, (2) how gender -integrated training was affecting ...research. This Special Report summarizes ARI’s research on gender issues and provides an annotated bibliography of other research and studies that have been...various issues related to women in the Army, specifically, the integration and utilization of women, gender integration of basic training, and attitudes and

America's Children: Key National Indicators of Well-Being 2007

ERIC Educational Resources Information Center

Federal Interagency Forum on Child and Family Statistics, 2007

2007-01-01

This document is a compendium of indicators--drawn from the most reliable official statistics--illustrative of both the promises and the difficulties confronting our Nation's young people. The report summarizes 38 key indicators of child well-being and monitors changes in these indicators. The 38 indicators depict the well-being of children in the…

Academic Primer Series: Five Key Papers for Consulting Clinician Educators.

PubMed

Chan, Teresa M; Gottlieb, Michael; Quinn, Antonia; London, Kory; Conlon, Lauren W; Ankel, Felix

2017-02-01

Clinician educators are often asked to perform consultations for colleagues. Invitations to consult and advise others on local problems can help foster great collaborations between centers, and allows for an exchange of ideas between programs. In this article, the authors identify and summarize several key papers to assist emerging clinician educators with the consultation process. A consensus-building process was used to generate a list of key papers that describe the importance and significance of educational consulting, informed by social media sources. A three-round voting methodology, akin to a Delphi study, determined the most impactful papers from the larger list. Summaries of the five most highly rated papers on education consultation are presented in this paper. These papers were determined by a mixed group of junior and senior faculty members, who have summarized these papers with respect to their relevance for their peer groups. Five key papers on the educational consultation process are presented in this paper. These papers offer background and perspective to help junior faculty gain a grasp of consultation processes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

No, author

This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors inmore » Section 4, and discuss bene ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.« less

Voices from School and Home: Arkansas Parents and Students Talk about Preparing for the World of Work and the Potential for Youth Apprenticeship. A Report on Focus Group Discussions.

ERIC Educational Resources Information Center

Jobs for the Future, Inc., West Somerville, MA.

This report summarizes several group discussions with parents of high school students, high school students, and nursing students regarding the world of work and the advantages and disadvantages of a youth apprenticeship program. Section I is an executive summary that describes the methodology, summarizes key attitudes toward youth apprenticeships…

Externally blown flap noise research

NASA Technical Reports Server (NTRS)

Dorsch, R. G.

1974-01-01

The Lewis Research Center cold-flow model externally blown flap (EBF) noise research test program is summarized. Both engine under-the-wing and over-the-wing EBF wing section configurations were studied. Ten large scale and nineteen small scale EBF models were tested. A limited number of forward airspeed effect and flap noise suppression tests were also run. The key results and conclusions drawn from the flap noise tests are summarized and discussed.

76 FR 26290 - Science Advisory Board Staff Office; Notification of a Public Teleconference of the Chartered...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-06

... report entitled ``SAB Review of EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to... of EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments.'' The SAB... Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments.'' To conduct this review...

Wild edible mushrooms in the Blue Mountains: resource and issues.

Treesearch

Catherine G. Parks; Craig L. Schmitt

1997-01-01

This paper reviews the wild mushroom resource of the Blue Mountains of northeastern Oregon and southeastern Washington and summarizes issues and concerns for regulation, monitoring, and management. Existing biological information on the major available commercial mushrooms in the area, with emphasis on morels, is presented. Brief descriptions of the most commonly...

Critical Issues in Native North America. IWGIA Document No. 62.

ERIC Educational Resources Information Center

Churchill, Ward, Ed.

This collection of articles compares the problems and issues facing indigenous nations within the United States and Canada and examines forms of native resistance. Glenn T. Morris and M. Annette Jaimes summarize the evolution of the "legal status" of indigenous nations under U.S. law and examine how U.S. legal definitions undermine…

The personal aircraft: Status and issues

NASA Technical Reports Server (NTRS)

Anders, Scott G.; Asbury, Scott C.; Brentner, Kenneth S.; Bushnell, Dennis M.; Glass, Christopher E.; Hodges, William T.; Morris, Shelby J., Jr.; Scott, Michael A.

1994-01-01

Paper summarizes the status of personal air transportation with emphasis upon VTOL and converticar capability. The former obviates the need for airport operations for personal aircraft whereas the latter provides both ground and air capability in the same vehicle. Fully automatic operation, ATC and navigation is stressed along with consideration of acoustic, environmental and cost issues.

Youth Development: Issues, Challenges and Directions.

ERIC Educational Resources Information Center

Jaffe, Natalie, Ed.

The Youth Development Project was established in 1998 as a vehicle for taking stock of and charting the issues involved in healthy youth development. This volume summarizes the project's work through papers prepared for discussions in May and October 1998 and edited for this collection. The essays in this volume are organized by three theme…

Trends and Issues in ELT Methods and Methodology

ERIC Educational Resources Information Center

Waters, Alan

2012-01-01

Trends and issues in ELT methods and methodology can be identified at two main levels. One is in terms of the theoretical pronouncements of the "professional discourse", as manifested by major publications, conference presentations, and so on. This article therefore begins by briefly summarizing some of the main developments of this kind from 1995…

Non-English Speaking Background Workers' Literacies--a Health and Safety Issue.

ERIC Educational Resources Information Center

Wyatt-Smith, Claire; Castleton, Geraldine

1995-01-01

Summarizes the experiences of workers from non-English-speaking backgrounds (NESB) in accessing safety information. The article examines the issue through the workers' eyes and focuses on the potential relationships between language and literacy and workplace health and safety and a concern for the reasons why some NESB workers are losers in…

State-Tribal Legislation: 1992 and 1993 Summaries.

ERIC Educational Resources Information Center

White-Tail Feather, Alex; And Others

This report summarizes state legislative activity in 1992 and 1993 pertaining to Native American issues. An overview of each year is followed by state-by-state summaries. In 1993, of 238 bills, resolutions, and memorials introduced, 116 were enacted, with 31 pending. During 1993, education issues were important and included the integration of…

Return to Work Following Traumatic Brain Injury. Special Issue, Volume 5, Number 1.

ERIC Educational Resources Information Center

Goodall, Patricia, Ed.

The report examines employment service issues related to assisting persons who have suffered traumatic brain injury to re-enter the labor force and maintain their employment. An interdisciplinary team treatment approach is recommended and the roles of each of the following professionals are summarized: employment specialist, neuropsychologist,…

Teachers' Views on World Issues: A Digest of the Policies of WCOTP.

ERIC Educational Resources Information Center

World Confederation of Organizations of the Teaching Profession, Morges (Switzerland).

This document summarizes the policies of the World Confederation of Organisations of the Teaching Profession (WCOTP) in relation to a wide range of topics affecting education and the status of teachers. Topical areas are covered in four sections: education, teachers, women, and contemporary world issues. Section 1, "Education," looks at…

At-Risk Children and Youth: A Crisis in Our Schools and Society.

ERIC Educational Resources Information Center

Davis, William E.; McCaul, Edward J.

This monograph presents a synthesis of current concerns and information relative to at-risk children. The report summarizes and discusses major issues concerning contemporary definitions of "at risk," the history of concern over at-risk children, general factors and conditions involved in placing children at risk, and contemporary issues regarding…

Therapeutic issues of marijuana and THC (tetrahydrocannabinol).

PubMed

Ungerleider, J T; Andrysiak, T

1985-05-01

This article summarizes current knowledge about the medicinal value of cannabis and its principal psychoactive ingredient, delta 9-tetrahydrocannabinol (THC), particularly in the control of nausea and vomiting, in glaucoma, and in reduction of spasticity in multiple sclerosis. The major issues in the controversy about marijuana and medicine, primarily moral and ethical, are discussed.

Value-Added Model (VAM) Research for Educational Policy: Framing the Issue

ERIC Educational Resources Information Center

Amrein-Beardsley, Audrey; Collins, Clarin; Polasky, Sarah A.; Sloat, Edward F.

2013-01-01

In this manuscript, the guest editors of the EPAA Special Issue on "Value-Added Model (VAM) Research for Educational Policy" (1) introduce the background and policy context surrounding the increased use of VAMs for teacher evaluation and accountability purposes across the United States; (2) summarize the five research papers and one…

Preschool and Economic Development. Employment Research. Volume 13, Number 4

ERIC Educational Resources Information Center

Bartik, Timothy J.

2006-01-01

"Employment Research" is published quarterly by the W.E. Upjohn Institute for Employment and Research. Issues appear in January, April, July, and October. This issue of "Employment Research" presents an article that summarizes the author's study of the effects of high-quality universal preschool education when it is treated as an economic…

LGBTQ Research in Higher Education: A Review of Journal Articles, 2000-2003

ERIC Educational Resources Information Center

Dilley, Patrick

2004-01-01

A review of electronic databases identified 27 research-based articles concerning LGBTQ issues in higher education between 2000 and 2003. These articles are summarized into three categories: studies of campus climate, student life issues, and college teaching. Suggestions are provided for future research on postsecondary students; faculty;…

Peer Review of a Formal Verification/Design Proof Methodology

NASA Technical Reports Server (NTRS)

1983-01-01

The role of formal verification techniques in system validation was examined. The value and the state of the art of performance proving for fault-tolerant compuers were assessed. The investigation, development, and evaluation of performance proving tools were reviewed. The technical issues related to proof methodologies are examined. The technical issues discussed are summarized.

Health effects of Aspergillus in food and air.

PubMed

Klich, Maren A

2009-01-01

This review summarizes the health aspects of the medically important fungal genus Aspergillus. The morphology and systematics of the genus are explained as well as its biogeography. Major mycotoxins, the aspergilli that produce them, affected crops, and symptoms of the toxicoses are summarized, as are the major mycoses caused by aspergilli. The current status of the relationship between Aspergillus in the indoor environment and health issues are discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lundergan, C. D.; Mead, P. L.

This report is a compilation of 17 individual documents that together summarize the technical capabilities of Sandia Laboratories. Each document in this compilation contains details about a specific area of capability. Examples of application of the capability to research and development problems are provided. An eighteenth document summarizes the content of the other seventeen. Each of these documents was issued with a separate report number (SAND 74-0073A through SAND 74-0091, except -0078). (RWR)

The virtual windtunnel: Visualizing modern CFD datasets with a virtual environment

NASA Technical Reports Server (NTRS)

Bryson, Steve

1993-01-01

This paper describes work in progress on a virtual environment designed for the visualization of pre-computed fluid flows. The overall problems involved in the visualization of fluid flow are summarized, including computational, data management, and interface issues. Requirements for a flow visualization are summarized. Many aspects of the implementation of the virtual windtunnel were uniquely determined by these requirements. The user interface is described in detail.

Building on the Momentum.... Proceedings from the 10th Anniversary Celebration of the National Education Goals Panel (Washington, DC, December 1-2, 1999).

ERIC Educational Resources Information Center

Tyson-Bernstein, Harriet

These proceedings summarize the themes and events of the 10th anniversary celebration of the National Education Goals Panel (NEGP). The proceedings are divided into three sections. The first section summarizes significant themes and issues raised over the 2-day event. The second section is a synopsis of discussions that took place during the…

Radioactive materials released from nuclear power plants. Annual report, 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Benkovitz, C.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1980 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1980 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

Radioactive materials released from nuclear power plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Norden, K.; Congemi, J.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1987 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1987 release data are summarized in tabular form. Data covering specific radionuclides are summarized. 16 tabs.

Radioactive materials released from nuclear power plants: Annual report, 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Norden, K.; Congemi, J.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1984 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1984 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

Radioactive materials released from nuclear power plants: Annual report, 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Norden, K.; Congemi, J.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1985 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1985 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

Radioactive materials released from nuclear power plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Norden, K.; Congemi, J.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1988 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1988 release data are summarized in tabular form. Data covering specific radionuclides are summarized. 16 tabs.

Added value of involving patients in the first step of multidisciplinary guideline development: a qualitative interview study among infertile patients.

PubMed

den Breejen, Elvira M E; Hermens, Rosella P M G; Galama, Wienke H; Willemsen, Wim N P; Kremer, Jan A M; Nelen, Willianne L D M

2016-06-01

Patient involvement in scoping the guideline is emphasized, but published initiatives actively involving patients are generally limited to the writing and reviewing phase. To assess patients' added value to the scoping phase of a multidisciplinary guideline on infertility. Qualitative interview study. We conducted interviews among 12 infertile couples and 17 professionals. We listed and compared the couples' and professionals' key clinical issues (=care aspects that need improvement) to be addressed in the guideline according to four domains: current guidelines, professionals, patients and organization of care. Main key clinical issues suggested by more than three quarters of the infertile couples and/or at least two professionals were identified and compared. Overall, we identified 32 key clinical issues among infertile couples and 23 among professionals. Of the defined main key clinical issues, infertile couples mentioned eight issues that were not mentioned by the professionals. These main key clinical issues mainly concerned patient-centred (e.g. poor information provision and poor alignment of care) aspects of care on the professional and organizational domain. Both groups mentioned two main key clinical issues collectively that were interpreted differently: the lack of emotional support and respect for patients' values. Including patients from the first phase of the guideline development process leads to valuable additional main key clinical issues for the next step of a multidisciplinary guideline development process and broadens the scope of the guideline, particularly regarding patient-centredness and organizational issues from a patients' perspective. © The Author 2016. Published by Oxford University Press in association with the International Society for Quality in Health Care; all rights reserved.

Ignition at NIF: Where we have been, and where we are going

NASA Astrophysics Data System (ADS)

Rosen, Mordecai

2014-10-01

This talk reviews results from the past several years in the pursuit of indirect-drive ignition on the National Ignition Facility (NIF), and summarizes ideas and plans for moving forward. We describe the challenging issues encountered by the low-adiabat (``low foot''), ``ignition point design'' approach, such as: hydrodynamic instability growth and ensuing mix of the CH ablator into the DT hot spot; very high convergence implosions with resultant imperfect symmetry; possible other issues such as hot electron preheat. The complex interplay among these issues is a key theme. We describe the progress that has been made in the understanding and diagnosis of these issues. We present the results from the high-adiabat (``high foot'') approach, with its property of relative hydrodynamic stability when compared to the low foot approach, its somewhat reduced convergence ratio, and its achievement of entering the alpha heating regime, an important milestone on the road to ignition. Paths forward towards ignition include excursions from the present approaches in pulse shape, hohlraum, and choice of ablator. Further pulse shaping can lower the adiabat of the high foot approach and lead to higher performance if it continues to retain its hydrodynamic stability properties. Conversely, pulse shaping can provide for ``adiabat-shaping'' for the low foot approach for it to try to attain better stability. A plethora of hohlraum approaches (size, shape, materials, gas fills) can improve the zero-order drive, as well as the low-mode shape of the implosion. Diagnosing, and then correcting, the time dependence of the symmetry is also a key issue. A variety of ablator materials, along with carefully engineering the drive spectrum, can increase implosion velocity. The high-density carbon ablator has shown promising results in this regard. Some combinations of these developments may allow for an operating space that has a relatively short pulse, in a near vacuum hohlraum. That combination has shown, to date, much better coupling efficiency, and a much lower level of laser plasma instabilities (thus, less electron preheat), than the longer pulse, full gas-fill, ignition hohlraums. Advances in modeling, experimental platforms, and diagnostic techniques developed over the past several years have been key enabling technologies in moving towards ignition, and we anticipate further advances as well. We gratefully acknowledge the dedicated efforts of many hundreds of personnel across the globe who have participated in the laser construction, operation, target fabrication, and all aspects of the target physics program, that have taken us this far towards ignition. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Health, Wellness, and Substance Abuse Prevention. INAR/NACIE Joint Issues Sessions. National Indian Education Association (NIEA) Annual Conference (22nd, San Diego, California, October 15, 1990).

ERIC Educational Resources Information Center

National Advisory Council on Indian Education, Washington, DC.

This report summarizes two joint sessions held by the Indian Nations At Risk Task Force and the National Advisory Council on Indian Education to hear testimony on health and substance abuse prevention issues relevant to Native American children. Issues and problems fell into the following areas: (1) general health and wellness, including the need…

Trends in Learning Outcomes Assessment. Key Findings from a Survey among Administrators at AAC&U Member Institutions

ERIC Educational Resources Information Center

Association of American Colleges and Universities, 2016

2016-01-01

This 2016 report summarizes key findings from a national survey among chief academic officers at Association of American Colleges & Universities (AAC&U) member institutions and explores trends in learning outcomes and approaches to assessing them. It documents that many in higher education are moving away from standardized tests and…

Role of national labs in energy and environmental R & D: An industrial perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vaz, N.

1995-12-31

The perceived role of national laboratories in energy and environmental research and development is examined from an industrial perspective. A series of tables are used to summarize issues primarily related to the automotive industry. Impacts of policy on energy, environment, society, and international competition are outlined. Advances and further needs in automotive efficiency and pollution control, and research roles for national labs and industry are also summarized. 6 tabs.

Radioactive materials released from nuclear power plants. Annual report 1991, Volume 12

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Doty, K.; Congemi, J.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1991 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1991 release data are summarized in tabular form. Data Covering specific radionuclides are summarized.

Radioactive materials released from nuclear power plants. Annual report, 1982. Volume 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Norden, K.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1982 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1982 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

Radioactive materials released from nuclear power plants. Volume 11: Annual report, 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Doty, K.; Congemi, J.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1990 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1990 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

Radioactive materials released from nuclear power plants. Annual report 1981. Vol. 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Benkovitz, C.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1981 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1981 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

Radioactive materials released from nuclear power plants. Annual report, 1983. Volume 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tichler, J.; Norden, K.

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1983 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1983 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

SPS Energy Conversion Power Management Workshop

NASA Technical Reports Server (NTRS)

1980-01-01

Energy technology concerning photovoltaic conversion, solar thermal conversion systems, and electrical power distribution processing is discussed. The manufacturing processes involving solar cells and solar array production are summarized. Resource issues concerning gallium arsenides and silicon alternatives are reported. Collector structures for solar construction are described and estimates in their service life, failure rates, and capabilities are presented. Theories of advanced thermal power cycles are summarized. Power distribution system configurations and processing components are presented.

Japan-Specific Key Regulatory Aspects for Development of New Biopharmaceutical Drug Products.

PubMed

Desai, Kashappa Goud; Obayashi, Hirokazu; Colandene, James D; Nesta, Douglas P

2018-03-28

Japan represents the third largest pharmaceutical market in the world. Developing a new biopharmaceutical drug product for the Japanese market is a top business priority for global pharmaceutical companies while aligning with ethical drivers to treat more patients in need. Understanding Japan-specific key regulatory requirements is essential to achieve successful approvals. Understanding the full context of Japan-specific regulatory requirements/expectations is challenging to global pharmaceutical companies due to differences in language and culture. This article summarizes key Japan-specific regulatory aspects/requirements/expectations applicable to new drug development, approval, and postapproval phases. Formulation excipients should meet Japan compendial requirements with respect to the type of excipient, excipient grade, and excipient concentration. Preclinical safety assessments needed to support clinical phases I, II, and III development are summarized. Japanese regulatory authorities have taken appropriate steps to consider foreign clinical data, thereby enabling accelerated drug development and approval in Japan. Other important topics summarized in this article include: Japan new drug application-specific bracketing strategies for critical and noncritical aspects of the manufacturing process, regulatory requirements related to stability studies, release specifications and testing methods, standard processes involved in pre and postapproval inspections, management of postapproval changes, and Japan regulatory authority's consultation services available to global pharmaceutical companies. Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Academic Primer Series: Five Key Papers about Study Designs in Medical Education.

PubMed

Gottlieb, Michael; Chan, Teresa M; Fredette, Jenna; Messman, Anne; Robinson, Daniel W; Cooney, Robert; Boysen-Osborn, Megan; Sherbino, Jonathan

2017-06-01

A proper understanding of study design is essential to creating successful studies. This is also important when reading or peer reviewing publications. In this article, we aimed to identify and summarize key papers that would be helpful for faculty members interested in learning more about study design in medical education research. The online discussions of the 2016-2017 Academic Life in Emergency Medicine Faculty Incubator program included a robust and vigorous discussion about education study design, which highlighted a number of papers on that topic. We augmented this list of papers with further suggestions by expert mentors. Via this process, we created a list of 29 papers in total on the topic of medical education study design. After gathering these papers, our authorship group engaged in a modified Delphi approach to build consensus on the papers that were most valuable for the understanding of proper study design in medical education. We selected the top five most highly rated papers on the topic domain of study design as determined by our study group. We subsequently summarized these papers with respect to their relevance to junior faculty members and to faculty developers. This article summarizes five key papers addressing study design in medical education with discussions and applications for junior faculty members and faculty developers. These papers provide a basis upon which junior faculty members might build for developing and analyzing studies.

Scaling up the global nursing health workforce: contributions of an international organization.

PubMed

Rukholm, Ellen E; Stamler, Lynnette Leeseberg; Talbot, Lise R; Bednash, Geraldine; Raines, Fay; Potempa, Kathleen; Nugent, Pauline; Clark, Dame Jill Macleod; Bernhauser, Sue; Parfitt, Barbara

2009-01-01

In this paper key highlights of the scholarly work presented at the Toronto 2008 Global Alliance for Nursing Education & Scholarship (GANES) conference are summarized, challenges opportunities and issues facing nursing education globally arising from the conference discourse are outlined and initial steps are suggested as a way forward to a shared global view of baccalaureate and graduate nursing education and scholarship. This shared view arises from beginning understandings of the issues and opportunities we face globally starting with and building upon the lessons learned from the literature and from the experiences of nursing educators and nursing education organization locally, regionally, nationally and internationally. The theme of the groundbreaking GANES Toronto conference was "Educating the future nursing and health workforce: A global challenge". One hundred seventy delegates from 17 countries attended the event, with over 80 papers presented. A primary focus of GANES is the contribution of a strategic alliance of national nursing education organizations to contribute to nursing education leading practices and policy that address the scaling up of global nursing and health workforce. The founding members of GANES see a clear link between a strong educational infrastructure and strong scholarship activities in nursing and the ability of a society to be healthy and prosperous. Evidence presented at the recent GANES conference supports that belief. Through the strength of partnerships and other capacity-building efforts, member countries can support each other to address the global nursing education and health challenges while respecting the local issues.

Community Mobilization and Readiness: Planning Flaws which Challenge Effective Implementation of 'Communities that Care' (CTC) Prevention System.

PubMed

Basic, Josipa

2015-01-01

This article reviews the experience of implementing a community approach to drug use and youth delinquency prevention based on the 'Communities that Care' (CTC) system implemented in one Croatian county consisting of 12 communities, 2002 to 2013 (Hawkins, 1999; Hawkins & Catalano, 2004). This overview explores selected critical issues which are often not considered in substance use(r) community intervention planning, implementation as well as in associated process and outcome assessments. These issues include, among others, the mobilization process of adequate representation of people; the involvement of relevant key individual and organizational stakeholders and being aware of the stakeholders' willingness to participate in the prevention process. In addition, it is important to be aware of the stakeholders' knowledge and perceptions about the 'problems' of drug use and youth delinquency in their communities as well as the characteristics of the targeted population(s). Sometimes there are community members and stakeholders who block needed change and therefore prevention process enablers and 'bridges' should be involved in moving prevention programming forward. Another barrier that is often overlooked in prevention planning is community readiness to change and a realistic assessment of available and accessible resources for initiating the planned change(s) and sustaining them. All of these issues have been found to be potentially related to intervention success. At the end of this article, I summarize perspectives from prevention scientists and practitioners and lessons learned from communities' readiness research and practice in Croatian that has international relevance.

The Gulf Coast Future Issues Council, Inc. Summary Report, June 1, 1984 to November 30, 1984.

ERIC Educational Resources Information Center

Vaughan, Jerry L.

Focusing on the period from June, 1984 through November, 1984, this report summarizes the activities of the Gulf Coast Future Issues Council (GCFIC), a non-profit corporation organized as a coordination center of community research, forecasting, trend analysis, and educational activities. After introductory material that highlights the role of the…

Estimating College Enrollment Rates for Virginia Public High School Graduates. Summary. Issues & Answers. REL 2011-No. 104

ERIC Educational Resources Information Center

Holian, Laura; Mokher, Christine

2011-01-01

This brief document summarizes findings from "Estimating College Enrollment Rates for Virginia Public High School Graduates. Issues & Answers. REL 2011-No. 104." Using data from the National Student Clearinghouse and the Virginia Department of Education, the report examines college enrollment rates overall and by student academic and…

A Content and Methodological Review of Articles Concerning Multiracial Issues in Six Major Counseling Journals

ERIC Educational Resources Information Center

Edwards, Lisa M.; Pedrotti, Jennifer Teramoto

2008-01-01

This study describes a comprehensive content and methodological review of articles about multiracial issues in 6 journals related to counseling up to the year 2006. The authors summarize findings about the 18 articles that emerged from this review of the "Journal of Counseling Psychology," "Journal of Counseling & Development," "The Counseling…

Strengthening Education in the Muslim World. Summary of the Desk Study. Issue Paper.

ERIC Educational Resources Information Center

Benoliel, Sharon

This issue paper, one in a series that United States Agency for International Development (USAID) produces, provides analytical input to policy makers and practitioners on ways to address the pressing educational challenges in the Muslim world. The paper summarizes the findings and guidance contained in a full report of a three month desk study…

Preliminary evaluation of hermetic JT/LJT/R P connector socket contact design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baca, J.R.F.

1991-10-01

This report presents a precursory examination of a number of issues pertaining to socket contacts in hermetic connectors. The principal issues addressed are high-contact resistance and contact chatter (circuit discontinuities). Efforts examining the characteristics of the existing socket contact design, the possibility of connector/contact rework, quick-fix solutions, and contact redesigns are summarized.

Framing the issues affecting northern forests

Treesearch

Stephen R. Shifley; Francisco X. Aguilar; Nianfu Song; Susan I. Stewart; David J. Nowak; Dale D. Gormanson; W. Keith Moser; Sherri Wormstead; Eric J. Greenfield

2012-01-01

People in the North are concerned about forests, especially the forests near to them. Concerns reflect their diverse connections to forests and the many ways that rural and urban forests affect their quality of life. A recent analysis by Dietzman et al. (2011) summarized more than 700 comments about issues facing northern forests. The comments came from 74 print and...

Drugs and Addict Lifestyles. National Institute on Drug Abuse Research Issues 7.

ERIC Educational Resources Information Center

Ferguson, Patricia, Ed.; And Others

This report is the seventh in a series intended to summarize the empirical research findings and major theoretical approaches relating to the issues of drug use and abuse. This volume reviews the research undertaken to describe the lifestyle histories of heroin users. These research findings are formulated and detailed to provide the reader with…

Minority Students & Special Education: The Issues of Placement and Proportion. Model Programs and Practical Approaches. Spring Conference.

ERIC Educational Resources Information Center

Williams, Idola J., Ed.; Goodale, Ronda, Ed.

The second of two documents on issues concerned with limited English speaking students in Massachusetts special education programs, this report presents proceedings from a 1982 conference. Sixteen presentations are summarized and results of participants' evaluations on six-item questionnaires are included. Topics covered in the workshop sessions…

Misdiagnosing the Teacher Quality Problem. CPRE Policy Briefs. RB-49

ERIC Educational Resources Information Center

Ingersoll, Richard M.

2007-01-01

This issue of CPRE Policy Briefs summarizes the findings on issues related to teacher quality in the chapter by the author in the book, "The State of Education Policy Research" (Cohen, Fuhrman, Mosher, Eds., 2007). This report also draws on discussions that took place during a summer, 2006, policy briefing on teacher labor-market issues…

The Campus Green: Fund Raising in Higher Education. ERIC Digest.

ERIC Educational Resources Information Center

Brittingham, Barbara E.; Pezzullo, Thomas R.

This digest summarizes issues raised in a research report on fund raising in higher education. The following questions are addressed: What are the changes and trends since the early days of educational fund raising? What are the implications? What is known about spending? What is known about donor behavior? What are the major ethical issues? What…

Asian Americans: An Agenda for Action; A Conference Summary.

ERIC Educational Resources Information Center

Azores, Fortunata M.

The proceedings of a conference on Asian Americans held in New York City in May 1978 are summarized in this report. The conference consisted of workshops on four issues: employment, voter participation, youth, and the elderly. In the workshop on employment, issues discussed included the participation of Asians in the health system and in the…

Democracy's College: The American Community College in the 21st Century--Framing the Issue

ERIC Educational Resources Information Center

Topper, Amelia M.; Powers, Jeanne M.

2013-01-01

In this manuscript, the guest editors of the EPAA Special Issue on "Democracy's College: The American Community College in the 21st Century": a) introduce the background, history, and context of community colleges in the larger higher education landscape; b) summarize the three research papers and two video commentaries that were…

Education Issues Raised by S.744: The Border Security, Economic Opportunity, and Immigration Modernization Act

ERIC Educational Resources Information Center

Murphy, Garrett

2014-01-01

This brief report summarizes the requirements for undocumented immigrants set forth by the Border Security, Economic Opportunity, and Immigration Modernization Act (S.744). Assuming that S.744 will move forward in Congress, the report also examines issues having to do with certain language, civics and government, and education/training provisions…

Teaching Ethics and Values in Public Administration Programs: Innovations, Strategies, and Issues. SUNY Series in Public Administration.

ERIC Educational Resources Information Center

Bowman, James, Ed.; Menzel, Donald, Ed.

The 17 chapters in this book consider innovations, teaching strategies, and issues in ethics instruction for professional and graduate programs in public affairs/administration. Following an introductory chapter which summarizes data reported in a 1995 national survey of 138 graduate departments of public affairs/administration, chapter titles…

Facial Surgery and an Active Modification Approach for Children with Down Syndrome: Some Psychological and Ethical Issues.

ERIC Educational Resources Information Center

Mearig, Judith S.

1985-01-01

The article summarizes some major issues involved including social acceptance of and expectations for individuals with Down syndrome; valuing of physical appearance; relevance of intellectual functioning; infliction of avoidable pain or trauma; origins and import of medical professionals' opinions; and the individual's desire for and reactions to…

Education Studies: Issues & Critical Perspectives

ERIC Educational Resources Information Center

Kassem, Derek; Mufti, Emmanuel; Robinson, John

2006-01-01

This major text for Education Studies students provides a critical account of key issues in education today. The text features: (1) A critical analysis of key issues in Education Studies to encourage students' thinking about education in the broadest terms; (2) Themed sections with introductions to link the issues discussed in each chapter; (3)…

The HHS-HCC Risk Adjustment Model for Individual and Small Group Markets under the Affordable Care Act

PubMed Central

Kautter, John; Pope, Gregory C; Ingber, Melvin; Freeman, Sara; Patterson, Lindsey; Cohen, Michael; Keenan, Patricia

2014-01-01

Beginning in 2014, individuals and small businesses are able to purchase private health insurance through competitive Marketplaces. The Affordable Care Act (ACA) provides for a program of risk adjustment in the individual and small group markets in 2014 as Marketplaces are implemented and new market reforms take effect. The purpose of risk adjustment is to lessen or eliminate the influence of risk selection on the premiums that plans charge. The risk adjustment methodology includes the risk adjustment model and the risk transfer formula. This article is the second of three in this issue of the Review that describe the Department of Health and Human Services (HHS) risk adjustment methodology and focuses on the risk adjustment model. In our first companion article, we discuss the key issues and choices in developing the methodology. In this article, we present the risk adjustment model, which is named the HHS-Hierarchical Condition Categories (HHS-HCC) risk adjustment model. We first summarize the HHS-HCC diagnostic classification, which is the key element of the risk adjustment model. Then the data and methods, results, and evaluation of the risk adjustment model are presented. Fifteen separate models are developed. For each age group (adult, child, and infant), a model is developed for each cost sharing level (platinum, gold, silver, and bronze metal levels, as well as catastrophic plans). Evaluation of the risk adjustment models shows good predictive accuracy, both for individuals and for groups. Lastly, this article provides examples of how the model output is used to calculate risk scores, which are an input into the risk transfer formula. Our third companion paper describes the risk transfer formula. PMID:25360387

Introduction to the special issue: under pressure.

PubMed

Howard, Yetta

2013-01-01

This article introduces this special issue on the theme "Under Pressure." It uses an analysis of experimental lesbian filmmaker Su Friedrich's Seeing Red (2005) to frame the issue's focus on the ways that the category "lesbian" is placed under pressure and/or the pressure "lesbian" places on twentieth- and twenty-first-century cultural production. After this overview, the introduction summarizes all seven articles in the order that they appear in the issue. These summaries also show the connections between the articles and suggest possibilities for future critical dialogues on the theme.

Editorial: Special Issue on Experimental Vibration Analysis

NASA Astrophysics Data System (ADS)

Serra, Roger

2018-04-01

The vibratory analyses are particularly present today in the various fields of industry, from aeronautics to manufacturing, from machining and maintenance to civil engineering, to mention a few areas, which have made this special issue a true need. The International Journal of Mechanics & Industry compiles a Special Issue on Experimental Vibration Analysis. More than thirty manuscripts were received by the international scientific committee on the 6th congress AVE2016 and only eight papers have been selected after completing a careful and rigorous peer-review process for the Special Issue, which are briefly summarized below.

The value of redundant measurements - highlights from AmeriFlux site visits using a portable eddy covariance system

NASA Astrophysics Data System (ADS)

Chan, S.; Billesbach, D. P.; Hanson, C. V.; Dengel, S.; Polonik, P.; Biraud, S.

2016-12-01

The AmeriFlux network conducts independent site visits using a portable eddy covariance system (PECS). Short-term (<2 weeks), side-by-side comparisons enable the network to evaluate inter-comparability between sites, improve data quality, and assess measurement uncertainty across the network. The PECS includes commonly used sensors for turbulent flux, radiation, and meteorological measurements which are maintained and calibrated using established best practices at levels at or above the manufacturer's recommendations. The importance of site visits was realized at the inception of the AmeriFlux network with the first site visit in 1997. Since that time, more than 180 site visits at over 120 different sites have been conducted. Site visit reports over the years have led to many key findings and important advances within the flux community which are highlighted in the presentation. Furthermore, we summarize and synthesize results from recent site comparisons that were conducted with the latest generation of the PECS (2013-present). The presentation quantifies observed differences between the PECS and network sites for key flux, radiation, and meteorological metrics. The aggregated comparisons provide insight into comparability amongst network sites as well as areas for improvement. We identify common errors and issues and discuss some best practices.

Ability grouping and science education reform: Policy and research base

NASA Astrophysics Data System (ADS)

Lynch, Sharon

This article reviews current policy trends concerning the practice of ability grouping in K-12 science education. Relevant statements of key policy-making, policy-influencing organizations such as the NSTA, AAAS, NSF, the National Research Council, the U.S. Office of Education Department of Civil Rights, NAACP, the National Governors' Association, programs related to the Jacob Javits Grants for the Gifted and Talented, and others are summarized. The author's interpretation of the various positions are presented herein. The article also explores the research base supporting the various policies on grouping by examining selected general research literature on grouping, followed by research that is science education specific. Methodological issues color the research findings. The ethical and pragmatic implications of developing research and policy are discussed. The conclusions are that there is a dearth of recent empirical research specifically related to ability grouping in science, and that the time is ripe for the concerted development of a research agenda by key players in science education reform. Moreover, as controversial and value-laden as the topic is, it should be noted that grouping practices alone are unlikely to influence science education reform unless considered in the context of comprehensive restructuring efforts at the local school level.Received: 10 April 1993; Revised: 26 August 1993;

Cultural Perspectives on the Aftereffects of Combat Trauma: Review of a Community Study of Bedouin IDF Servicemen and Their Families

PubMed Central

Caspi, Yael; Slobodin, Ortal; Klein, Ehud

2015-01-01

Combat trauma may affect servicemen from indigenous, traditional communities in ways that warrant special attention. The Bedouins, who enlist in the Israel Defense Forces (IDF) voluntarily, represent a unique, closed, collectivist cultural minority, potentially in a predicament in light of ongoing sociopolitical events. This paper summarizes findings and lessons learned from a community study of Bedouin IDF servicemen and their families residing in Israel’s Western Galilee. This is the only research endeavor to have addressed trauma exposure and posttraumatic reactions in this community. The sampling strategies and interview schedule were designed in consideration of participation barriers typical of hard-to-reach populations. Data collection followed an extended phase of liaising with key informants and building trust. Study limitations are discussed in terms of the challenges presented by this type of research. Interviews conducted with 317 men, 129 wives, and 67 mothers revealed high levels of trauma exposure and posttraumatic stress disorder (PTSD) in the men, and related distress in wives and mothers, but not in the children. The role of aggression in mediating the impact of PTSD and concepts such as shame, the loss of personal resources, and beliefs about retribution are highlighted as key issues for a culturally relevant understanding of traumatized indigenous communities. PMID:25973273

Cultural Perspectives on the Aftereffects of Combat Trauma: Review of a Community Study of Bedouin IDF Servicemen and Their Families.

PubMed

Caspi, Yael; Slobodin, Ortal; Klein, Ehud

2015-04-01

Combat trauma may affect servicemen from indigenous, traditional communities in ways that warrant special attention. The Bedouins, who enlist in the Israel Defense Forces (IDF) voluntarily, represent a unique, closed, collectivist cultural minority, potentially in a predicament in light of ongoing sociopolitical events. This paper summarizes findings and lessons learned from a community study of Bedouin IDF servicemen and their families residing in Israel's Western Galilee. This is the only research endeavor to have addressed trauma exposure and posttraumatic reactions in this community. The sampling strategies and interview schedule were designed in consideration of participation barriers typical of hard-to-reach populations. Data collection followed an extended phase of liaising with key informants and building trust. Study limitations are discussed in terms of the challenges presented by this type of research. Interviews conducted with 317 men, 129 wives, and 67 mothers revealed high levels of trauma exposure and posttraumatic stress disorder (PTSD) in the men, and related distress in wives and mothers, but not in the children. The role of aggression in mediating the impact of PTSD and concepts such as shame, the loss of personal resources, and beliefs about retribution are highlighted as key issues for a culturally relevant understanding of traumatized indigenous communities.

Attachment-informed therapy for adults: Towards a unifying perspective on practice.

PubMed

Berry, Katherine; Danquah, Adam

2016-03-01

We aimed to provide an integrated overview of the key goals and strategies of an attachment-informed psychotherapy by summarizing the literature describing the clinical implications of attachment theory for psychological therapy for adults. We carried out a narrative thematic review of 58 texts from a diverse range of therapeutic schools, until we agreed that we had reached a saturation of themes. We identified six key themes: Changing internal working models; the therapeutic relationship and creating a secure base; formulating and processing relationship experiences; countertransference; separation, termination and boundary issues; and working with different attachment styles or patterns. We discuss empirical evidence in relation to each theme and highlight areas for research. Attachment theory provides a useful framework to inform psychological therapy with adults, but there is a pressing need for further research to empirically demonstrate the 'added value' of an attachment perspective. Attachment theory should be used to inform individual psychological therapy in adulthood. From the outset of their careers, therapists should receive training and supervision to enhance their awareness of their own and their clients' attachment experiences and how these play out during therapy. There is a need for greater empirical research to investigate whether the degree to which therapists formulate and meet clients' attachment needs influences outcomes. © 2015 The British Psychological Society.

Testing for anaplastic lymphoma kinase rearrangement to target crizotinib therapy: oncology, pathology and health economic perspectives.

PubMed

Lee, James A; Bubendorf, Lukas; Stahel, Rolf; Peters, Solange

2013-05-01

Crizotinib is a first-in-class oral anaplastic lymphoma kinase (ALK) inhibitor targeting ALK-rearranged non-small-cell lung cancer. The therapy was approved by the US FDA in August 2011 and received conditional marketing approval by the European Commission in October 2012 for advanced non-small-cell lung cancer. A break-apart FISH-based assay was jointly approved with crizotinib by the FDA. This assay and an immunohistochemistry assay that uses a D5F3 rabbit monoclonal primary antibody were also approved for marketing in Europe in October 2012. While ALK rearrangement has relatively low prevalence, a clinical benefit is exhibited in more than 85% of patients with median progression-free survival of 8-10 months. In this article, the authors summarize the therapy and alternative test strategies for identifying patients who are likely to respond to therapy, including key issues for effective and efficient testing. The key economic considerations regarding the joint companion diagnostic and therapy are also presented. Given the observed clinical benefit and relatively high cost of crizotinib therapy, companion diagnostics should be evaluated relative to response to therapy versus correlation alone whenever possible, and both high inter-rater reliability and external quality assessment programs are warranted.

Neural foundations to moral reasoning and antisocial behavior

PubMed Central

Yang, Yaling

2006-01-01

A common feature of the antisocial, rule-breaking behavior that is central to criminal, violent and psychopathic individuals is the failure to follow moral guidelines. This review summarizes key findings from brain imaging research on both antisocial behavior and moral reasoning, and integrates these findings into a neural moral model of antisocial behavior. Key areas found to be functionally or structurally impaired in antisocial populations include dorsal and ventral regions of the prefrontal cortex (PFC), amygdala, hippocampus, angular gyrus, anterior cingulate and temporal cortex. Regions most commonly activated in moral judgment tasks consist of the polar/medial and ventral PFC, amygdala, angular gyrus and posterior cingulate. It is hypothesized that the rule-breaking behavior common to antisocial, violent and psychopathic individuals is in part due to impairments in some of the structures (dorsal and ventral PFC, amygdala and angular gyrus) subserving moral cognition and emotion. Impairments to the emotional component that comprises the feeling of what is moral is viewed as the primary deficit in antisocials, although some disruption to the cognitive and cognitive-emotional components of morality (particularly self-referential thinking and emotion regulation) cannot be ruled out. While this neurobiological predisposition is likely only one of several biosocial processes involved in the etiology of antisocial behavior, it raises significant moral issues for the legal system and neuroethics. PMID:18985107

The Water Risks of Hydraulic Fracturing (Fracking): Key Issues from the New California Assessment

NASA Astrophysics Data System (ADS)

Gleick, P. H.

2015-12-01

A key component of the Water-Energy Nexus is the effort over the past decade or so to quantify the volumes and form of water required for the energy fuel cycle from extraction to generation to waste disposal. The vast majority of the effort in this area has focused on the water needs of electricity generation, but other fuel-cycle components also entail significant water demands and threats to water quality. Recent work for the State of California (managed by the California Council on Science and Technology - CCST) has produced a new state-of-the-art assessment of a range of potential water risks associated with hydraulic fracturing and related oil and gas extraction, including volumetric water demands, methods of disposal of produced water, and aquifer contamination. For example, this assessment produced new information on the disposal of produced water in surface percolation pits and the potential for contamination of local groundwater (see Figure). Understanding these risks raises questions about current production and future plans to expand production, as well as tools used by state and federal agencies to manage these risks. This talk will summarize the science behind the CCST assessment and related policy recommendations for both water and energy managers.

Imaging of congenital heart disease in adults: choice of modalities.

PubMed

Orwat, Stefan; Diller, Gerhard-Paul; Baumgartner, Helmut

2014-01-01

Major advances in noninvasive imaging of adult congenital heart disease have been accomplished. These tools play now a key role in comprehensive diagnostic work-up, decision for intervention, evaluation for the suitability of specific therapeutic options, monitoring of interventions and regular follow-up. Besides echocardiography, magnetic resonance (CMR) and computed tomography (CT) have gained particular importance. The choice of imaging modality has thus become a critical issue. This review summarizes strengths and limitations of the different imaging modalities and how they may be used in a complementary fashion. Echocardiography obviously remains the workhorse of imaging routinely used in all patients. However, in complex disease and after surgery echocardiography alone frequently remains insufficient. CMR is particularly useful in this setting and allows reproducible and accurate quantification of ventricular function and comprehensive assessment of cardiac anatomy, aorta, pulmonary arteries and venous return including complex flow measurements. CT is preferred when CMR is contraindicated, when superior spatial resolution is required or when "metallic" artefacts limit CMR imaging. In conclusion, the use of currently available imaging modalities in adult congenital heart disease needs to be complementary. Echocardiography remains the basis tool, CMR and CT should be added considering specific open questions and the ability to answer them, availability and economic issues.

Potential environmental effects of energy conservation measures in northwest industries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baechler, M C; Gygi, K F; Hendrickson, P L

The Bonneville Power Administration (Bonneville) has identified 101 plants in the Pacific Northwest that account for 80% of the region's industrial electricity consumption. These plants offer a precise target for a conservation program. PNL determined that most of these 101 plants were represented by 11 major industries. We then reviewed 36 major conservation technologies used in these 11 industrial settings to determine their potential environmental impacts. Energy efficiency technologies designed for industrial use may result in direct or indirect environmental impacts. Effects may result from the production of the conservation measure technology, changes in the working environment due to differentmore » energy and material requirements, or changes to waste streams. Industry type, work-place conditions, worker training, and environmental conditions inside and outside the plant are all key variables that may affect environmental outcomes. To address these issues this report has three objectives: Describe potential conservation measures that Bonneville may employ in industrial programs and discuss potential primary impacts. Characterize industrial systems and processes where the measure may be employed and describe general environmental issues associated with each industry type. Review environmental permitting, licensing, and other regulatory actions required for industries and summarize the type of information available from these sources for further analysis.« less

Collective judicial management of mass toxic tort controversies: lessons and issues from the Agent Orange litigation.

PubMed

Novey, L B

1988-01-01

Viewing the Agent Orange litigation as a case study, this article explores the feasibility and desirability of strengthening the powers of the courts to manage toxic tort controversies en masse. The Agent Orange lawsuit, brought on behalf of potentially millions of Vietnam War veterans and family members, charged that herbicides used for military purposes during the war caused a wide range of health problems. This article first reviews the current national debate over how mass toxic tort controversies should be handled, including key legislative reform options, and describes how attention is increasingly focused on ways that the court system might better cope with mass toxic torts. The principal events of the Agent Orange litigation are then summarized, by which the litigation was consolidated into a massive class action, the class action was settled, and a streamlined plan for distributing the settlement fund was adopted. The article evaluates the outcome of the litigation, and discusses whether the solution there can and should be broadly applied to other mass toxic tort cases. This question depends, in part, on a series of complex legal and practical issues, but the author suggests that the question will also depend on what institutional role we expect the judiciary to play within society.

Focus on the Rashba effect

NASA Astrophysics Data System (ADS)

Bihlmayer, G.; Rader, O.; Winkler, R.

2015-05-01

The Rashba effect, discovered in 1959, continues to supply fertile ground for fundamental research and applications. It provided the basis for the proposal of the spin transistor by Datta and Das in 1990, which has largely inspired the broad and dynamic field of spintronics. More recent developments include new materials for the Rashba effect such as metal surfaces, interfaces and bulk materials. It has also given rise to new phenomena such as spin currents and the spin Hall effect, including its quantized version, which has led to the very active field of topological insulators. The Rashba effect plays a crucial role in yet more exotic fields of physics such as the search for Majorana fermions at semiconductor-superconductor interfaces and the interaction of ultracold atomic Bose and Fermi gases. Advances in our understanding of Rashba-type spin-orbit couplings, both qualitatively and quantitatively, can be obtained in many different ways. This focus issue brings together the wide range of research activities on Rashba physics to further promote the development of our physical pictures and concepts in this field. The present Editorial gives a brief account on the history of the Rashba effect including material that was previously not easily accessible before summarizing the key results of the present focus issue as a guidance to the reader.

Counselling in infertility: individual, couple and group interventions.

PubMed

Van den Broeck, Uschi; Emery, Marysa; Wischmann, Tewes; Thorn, Petra

2010-12-01

Infertility is considered a biopsychosocial crisis and infertility counselling is recommended as an integral part of a multidisciplinary approach. This article will outline the theoretical background and describe common interventions used in infertility counselling for individuals, couples and in a group setting. This article summarizes the proceedings of the first campus workshop of the Special interest group of Psychology and Counselling of the European Society for Human Reproduction and Embryology (ESHRE). Infertility counselling offers the opportunity to explore, discover and clarify ways of living more satisfyingly and resourcefully when fertility impairments have been diagnosed. The Heidelberg Fertility Consultation Service is presented as a framework for individual and couples counselling and highlights important issues in counselling patients. For group work a number of steps to set up a group within an infertility framework are discussed. In recent years, infertility counselling has become a specialist form of counselling requiring professional expertise and qualification. Key issues and common interventions are presented to raise awareness for the specific counselling needs of individuals and couples experiencing infertility and undergoing medical treatment. Mental health professionals new to the field of reproductive technologies as well as those in other areas of mental health counselling clients with fertility disorders can benefit from the topics addressed. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Methodological and Clinical Aspects of the Molecular Epidemiology of Mycobacterium tuberculosis and Other Mycobacteria

PubMed Central

Minias, Alina; van Ingen, Jakko; Rastogi, Nalin; Brzostek, Anna; Żaczek, Anna; Dziadek, Jarosław

2016-01-01

SUMMARY Molecular typing has revolutionized epidemiological studies of infectious diseases, including those of a mycobacterial etiology. With the advent of fingerprinting techniques, many traditional concepts regarding transmission, infectivity, or pathogenicity of mycobacterial bacilli have been revisited, and their conventional interpretations have been challenged. Since the mid-1990s, when the first typing methods were introduced, a plethora of other modalities have been proposed. So-called molecular epidemiology has become an essential subdiscipline of modern mycobacteriology. It serves as a resource for understanding the key issues in the epidemiology of tuberculosis and other mycobacterial diseases. Among these issues are disclosing sources of infection, quantifying recent transmission, identifying transmission links, discerning reinfection from relapse, tracking the geographic distribution and clonal expansion of specific strains, and exploring the genetic mechanisms underlying specific phenotypic traits, including virulence, organ tropism, transmissibility, or drug resistance. Since genotyping continues to unravel the biology of mycobacteria, it offers enormous promise in the fight against and prevention of the diseases caused by these pathogens. In this review, molecular typing methods for Mycobacterium tuberculosis and nontuberculous mycobacteria elaborated over the last 2 decades are summarized. The relevance of these methods to the epidemiological investigation, diagnosis, evolution, and control of mycobacterial diseases is discussed. PMID:26912567

Arsenic and Environmental Health: State of the Science and ...

EPA Pesticide Factsheets

Background: Exposure to inorganic and organic arsenic compounds is a major public health problem that affects hundreds of millions of people worldwide. Exposure to arsenic is associated with cancer and noncancer effects in nearly every organ in the body, and evidence is mounting for health effects at lower levels of arsenic exposure than previously thought. Building from a tremendous knowledge base with > 1,000 scientific papers published annually with “arsenic” in the title, the question becomes, what questions would best drive future research directions? Objectives: The objective is to discuss emerging issues in arsenic research and identify data gaps across disciplines. Methods: The National Institutes of Health’s National Institute of Environmental Health Sciences Superfund Research Program convened a workshop to identify emerging issues and research needs to address the multi-faceted challenges related to arsenic and environmental health. This review summarizes information captured during the workshop. Discussion: More information about aggregate exposure to arsenic is needed, including the amount and forms of arsenic found in foods. New strategies for mitigating arsenic exposures and related health effects range from engineered filtering systems to phytogenetics and nutritional interventions. Furthermore, integration of omics data with mechanistic and epidemiological data is a key step toward the goal of linking biomarkers of exposure and suscepti

UTBB FDSOI: Evolution and opportunities

NASA Astrophysics Data System (ADS)

Monfray, Stephane; Skotnicki, Thomas

2016-11-01

As today's 28 nm FDSOI (Fully Depleted Silicon On Insulator) technology is at the industrialization level, this paper aims to summarize the key advantages allowed by the thin BOX (Buried Oxide) of the FDSOI, through the technology evolution but also new opportunities, among logic applications and extending the possibilities offered by the platform. We will summarize how the advantages provided by the thin BOX have been first explored and developed, and how the back biasing techniques are the key to the outstanding performances provided by the FDSOI at low voltage. Then, as the FDSOI technology is also a solution to develop innovative platforms and applications, we will detail some opportunities. In particular, we will present monolithic 3D integration, ultra-low power devices for IoT (Internet of Things) and ultra-sensitive sensors.

Cancer screening in the older adult: issues and concerns.

PubMed

Craft, Melissa

2014-06-01

Making individual recommendations for cancer screening in older adult patients may be difficult and time consuming, because of the need to incorporate complex issues of life expectancy, health status, risks and benefits, and individual values and wishes. In this article, current recommendations and related risks and benefits are summarized. Specific issues and concerns are addressed, with suggestions for strategies to assist older adults in making screening decisions. Copyright © 2014 Elsevier Inc. All rights reserved.

Space Shuttle Orbiter corrosion history, 1981-1993: A review and analysis of issues involving structures and subsystems

NASA Technical Reports Server (NTRS)

1995-01-01

This report summarizes past corrosion issues experienced by the NASA space shuttle orbiter fleet. Design considerations for corrosion prevention and inspection methods are reviewed. Significant corrosion issues involving structures and subsystems are analyzed, including corrective actions taken. Notable successes and failures of corrosion mitigation systems and procedures are discussed. The projected operating environment used for design is contrasted with current conditions in flight and conditions during ground processing.

Strategies of Educational Decentralization: Key Questions and Core Issues.

ERIC Educational Resources Information Center

Hanson, E. Mark

1998-01-01

Explains key issues and forces that shape organization and management strategies of educational decentralization, using examples from Colombia, Venezuela, Argentina, Nicaragua, and Spain. Core decentralization issues include national and regional goals, planning, political stress, resource distribution, infrastructure development, and job…

Benzene | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Nitrate | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Radon | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Prevention | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Arsenic | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Cadmium | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Sunburn | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Highlights | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Introduction | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Mortality | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Survival | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Incidence | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Diagnosis | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Acknowledgments | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Treatment | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Home | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Weight | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Power beaming research at NASA

NASA Technical Reports Server (NTRS)

Rather, John D. G.

1992-01-01

NASA's current research activities to evaluate laser power beaming systems are summarized with regard to their applications of greatest interest. Key technical certainties and uncertainties pertaining to laser power beaming systems appropriate for space applications are quantified. A path of development is presented that includes maturation of key technology components for reliable laser and millimeter wave power beaming systems during the 1990s.

Reflections of Girls in the Media: A Two-Part Study on Gender and Media. Summary of Key Findings.

ERIC Educational Resources Information Center

1997

This pamphlet summarizes the key findings of a two-part study that investigated the messages that young women (age 10 to 17) get from the media. A content analysis examined messages to girls across a range of media most heavily used by adolescent girls: television, movies, magazines, music videos, television commercials, and magazine…

Director's Message | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Contact Us | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Summary Tables | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Indoor Tanning | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Science Education - Deja Vu Revised.

ERIC Educational Resources Information Center

Walsh, John

1982-01-01

Summarizes views expressed and issues raised at the National Convocation on Precollege Education in Mathematics and Science and another meeting to establish a coalition of affiliates for science and mathematics education. (DC)

Data Sources | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Fat Consumption | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Secondhand Smoke | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Early Detection | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

HPV Immunization | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Smoking Cessation | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Tobacco Use | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Data Resources | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Alcohol Consumption | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Custom Report | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Physical Activity | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

Quitting Smoking | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

NCI Dictionary | Cancer Trends Progress Report

Cancer.gov

The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

When courts intervene: public health, legal and ethical issues surrounding HIV, pregnant women, and newborn infants.

PubMed

Tessmer-Tuck, Jennifer A; Poku, Joseph K; Burkle, Christopher M

2014-11-01

Ninety-three percent of pediatric AIDS cases are the result of perinatal HIV transmission, a disease that is almost entirely preventable with early intervention, which reduces the risk of perinatal HIV infection from 25% to <2%. The American College of Obstetricians and Gynecologists and the American Academy of Pediatrics both recommend routine HIV testing of all pregnant women and at-risk newborn infants. When pregnant women decline HIV testing and/or treatment, public health, legal, and ethical dilemmas can result. Federal courts consistently uphold a woman's right to refuse medical testing and treatment, even though it may benefit her fetus/newborn infant. Federal courts also reliably respect the rights of parents to make health care decisions for their newborn infants, which may include declining medical testing and treatment. Confusing the issue of HIV testing and treatment, however, is the fact that there is no definitive United States Supreme Court ruling on the issue. State laws and standards vary widely and serve as guiding principles for practicing clinicians, who must be vigilant of ongoing legal challenges and changes in the states in which they practice. We present a case of an HIV-positive pregnant woman who declined treatment and then testing or treatment of her newborn infant. Ultimately, the legal system intervened. Given the rarity of such cases, we use this as a primer for the practicing clinician to highlight the public health, legal, and ethical issues surrounding prenatal and newborn infant HIV testing and treatment in the United States, including summarizing key state-to-state regulatory differences. Copyright © 2014 Elsevier Inc. All rights reserved.

Ethics in Community-University-Artist Partnered Research: Tensions, Contradictions and Gaps Identified in an 'Arts for Social Change' Project.

PubMed

Yassi, Annalee; Spiegel, Jennifer Beth; Lockhart, Karen; Fels, Lynn; Boydell, Katherine; Marcuse, Judith

Academics from diverse disciplines are recognizing not only the procedural ethical issues involved in research, but also the complexity of everyday "micro" ethical issues that arise. While ethical guidelines are being developed for research in aboriginal populations and low-and-middle-income countries, multi-partnered research initiatives examining arts-based interventions to promote social change pose a unique set of ethical dilemmas not yet fully explored. Our research team, comprising health, education, and social scientists, critical theorists, artists and community-activists launched a five-year research partnership on arts-for-social change. Funded by the Social Science and Humanities Research Council in Canada and based in six universities, including over 40 community-based collaborators, and informed by five main field projects (circus with street youth, theatre by people with disabilities, dance for people with Parkinson's disease, participatory theatre with refugees and artsinfused dialogue), we set out to synthesize existing knowledge and lessons we learned. We summarized these learnings into 12 key points for reflection, grouped into three categories: community-university partnership concerns ( n  = 3), dilemmas related to the arts ( n  = 5), and team issues ( n  = 4). In addition to addressing previous concerns outlined in the literature (e.g., related to consent, anonymity, dangerous emotional terrain, etc.), we identified power dynamics (visible and hidden) hindering meaningful participation of community partners and university-based teams that need to be addressed within a reflective critical framework of ethical practice. We present how our team has been addressing these issues, as examples of how such concerns could be approached in community-university partnerships in arts for social change.

Indicators of Marine Pollution in the North Pacific Ocean.

PubMed

Brown, Tanya M; Takada, Hideshige

2017-08-01

The complex nature of ocean pollution underscores the utility in identifying and characterizing a limited number of "indicators" that enables scientists and managers to track trends over space and time. This paper introduces a special issue on indicators of marine pollution in the North Pacific Ocean and builds on a scientific session that was held at the North Pacific Marine Science Organization. The special issue highlights studies using a variety of indicators to provide insight into the identification of legacy and emerging contaminants, the ranking of priority pollutants from various sources, and the effects of contaminants on ecosystem health in the North Pacific Ocean. Examples include the use of mussels to illustrate spatial and temporal trends of a number of contaminants following the 2011 tsunami in Japan, the use of molecular marker (linear alkylbenzenes, hopanes, and polycyclic aromatic hydrocarbons) profiles to identify pollution sources, and the use of plastic resin pellets to illustrate spatial trends of petroleum pollution around the world. Stable isotopes were used to strengthen the utility of the Glaucous-winged gull (Larus glaucescens) as an indicator of marine pollution. Examples also demonstrate the development and application of biomarker approaches, including gene transcripts, oxidative stress, estradiol, hatchability, and respiration and swimming behavior abnormalities, as a function of exposure to polychlorinated biphenyls, sulfur-diesel, Pinghu crude oil, galaxolide and antifouling biocides. We provide a brief review of indicators of marine pollution, identify research gaps, and summarize key findings from the articles published within the issue. This special issue represents the first compilation of research pertaining to marine pollution indicators in the North Pacific Ocean and provides guidance to inform mitigation and monitoring efforts of contaminants in the region.

An overview of the development of the first wall and other principal components of a laser fusion power plant

NASA Astrophysics Data System (ADS)

Sethian, John D.; Raffray, A. Rene; Latkowski, Jeffery; Blanchard, James P.; Snead, Lance; Renk, Timothy J.; Sharafat, Shahram

2005-12-01

This paper introduces the JNM Special Issue on the development of a first wall for the reaction chamber in a laser fusion power plant. In this approach to fusion energy a spherical target is injected into a large chamber and heated to fusion burn by an array of lasers. The target emissions are absorbed by the wall and encapsulating blanket, and the resulting heat converted into electricity. The bulk of the energy deposited in the first wall is in the form of X-rays (1.0-100 keV) and ions (0.1-4 MeV). In order to have a practical power plant, the first wall must be resistant to these emissions and suffer virtually no erosion on each shot. A wall candidate based on tungsten armor bonded to a low activation ferritic steel substrate has been chosen as the initial system to be studied. The choice was based on the vast experience with these materials in a nuclear environment and the ability to address most of the key remaining issues with existing facilities. This overview paper is divided into three parts. The first part summarizes the current state of the development of laser fusion energy. The second part introduces the tungsten armored ferritic steel concept, the three critical development issues (thermo-mechanical fatigue, helium retention, and bonding) and the research to address them. Based on progress to date the latter two appear to be resolvable, but the former remains a challenge. Complete details are presented in the companion papers in this JNM Special Issue. The third part discusses other factors that must be considered in the design of the first wall, including compatibility with blanket concepts, radiological concerns, and structural considerations.

THE NGA-DOE GRANT TO EXAMINE CRITICAL ISSUES RELATED TO RADIOACTIVE WASTE AND MATERIALS DISPOSITION INVOLVING DOE FACILITIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-01-01

Through the National Governors' Association (NGA) project ''Critical Issues Related to Radioactive Waste and Materials Disposition Involving DOE Facilities'' NGA brings together Governors' policy advisors, state regulators, and DOE officials to examine critical issues related to the cleanup and operation of DOE nuclear weapons and research facilities. Topics explored through this project include: Decisions involving disposal of mixed, low-level, and transuranic (TRU) waste and disposition of nuclear materials. Decisions involving DOE budget requests and their effect on environmental cleanup and compliance at DOE facilities. Strategies to treat mixed, low-level, and transuranic (TRU) waste and their effect on individual sites inmore » the complex. Changes to the FFCA site treatment plans as a result of proposals in the EM 2006 cleanup plans and contractor integration analysis. Interstate waste and materials shipments. Reforms to existing RCRA and CERCLA regulations/guidance to address regulatory overlap and risks posed by DOE wastes. The overarching theme of this project is to help the Department improve coordination of its major program decisions with Governors' offices and state regulators and to ensure such decisions reflect input from these key state officials and stakeholders. This report summarizes activities conducted during the quarter from October 1, 1997 through December 31, 1997, under the NGA project. The work accomplished by the NGA project team during the past four months can be categorized as follows: maintained open communication with DOE on a variety of activities and issues within the DOE environmental management complex; and maintained communication with NGA Federal Facilities Compliance Task Force members regarding DOE efforts to formulate a configuration for mixed low-level waste and low-level treatment and disposal, DOE activities in the area of the Hazardous Waste Identification Rule, and DOE's proposed National Dialogue.« less

On identity: from a philosophical point of view

PubMed Central

2013-01-01

Background The term “identity” has a much longer tradition in Western philosophy than in psychology. However, the philosophical discourse addresses very different meanings of the term, which should be distinguished to avoid misunderstandings, but also to sharpen the key meanings of the term in psychological contexts. These crucial points in the philosophical concepts of identity in the sense of singularity, individuality, or self-sameness may structure the ongoing discussion on identity in psychiatric diagnoses (as in DSM-5, Child Adolesc Psychiatry Ment, this issue, 2013), in psychology, psychoanalysis, but also neuroscience and neurophilosophy (Child Adolesc Psychiatry Ment, this issue, 2013). Method The concept of identity is subjected to a systematic philosophical analysis following some milestones in its history to provide a background for recent discussions on identity in psychiatry and psychology. Results The article focuses first on the philosophical core distinctions of identity in the different meanings to be addressed, second, briefly on some of the diverse psychological histories of the concept in the second half of the 20th century. Finally some reflections are presented on borderline personality disorder, considered as a mental disorder with a disturbance or diffusion of identity as core feature, and briefly on a newly developed instrument assessing identity development and identity diffusion in adolescence, the AIDA that is also presented in the special issue of this journal (Child Adolesc Psychiatry Ment, this issue, 2013). Conclusion As a conclusion, different points of view concerning identity are summarized in respect to treatment planning, and different levels of description of identity in phenomenology, philosophy of mind, cognitive science, and social science and personality psychology are outlined. PMID:23902741

Code qualification of structural materials for AFCI advanced recycling reactors.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Natesan, K.; Li, M.; Majumdar, S.

2012-05-31

This report summarizes the further findings from the assessments of current status and future needs in code qualification and licensing of reference structural materials and new advanced alloys for advanced recycling reactors (ARRs) in support of Advanced Fuel Cycle Initiative (AFCI). The work is a combined effort between Argonne National Laboratory (ANL) and Oak Ridge National Laboratory (ORNL) with ANL as the technical lead, as part of Advanced Structural Materials Program for AFCI Reactor Campaign. The report is the second deliverable in FY08 (M505011401) under the work package 'Advanced Materials Code Qualification'. The overall objective of the Advanced Materials Codemore » Qualification project is to evaluate key requirements for the ASME Code qualification and the Nuclear Regulatory Commission (NRC) approval of structural materials in support of the design and licensing of the ARR. Advanced materials are a critical element in the development of sodium reactor technologies. Enhanced materials performance not only improves safety margins and provides design flexibility, but also is essential for the economics of future advanced sodium reactors. Code qualification and licensing of advanced materials are prominent needs for developing and implementing advanced sodium reactor technologies. Nuclear structural component design in the U.S. must comply with the ASME Boiler and Pressure Vessel Code Section III (Rules for Construction of Nuclear Facility Components) and the NRC grants the operational license. As the ARR will operate at higher temperatures than the current light water reactors (LWRs), the design of elevated-temperature components must comply with ASME Subsection NH (Class 1 Components in Elevated Temperature Service). However, the NRC has not approved the use of Subsection NH for reactor components, and this puts additional burdens on materials qualification of the ARR. In the past licensing review for the Clinch River Breeder Reactor Project (CRBRP) and the Power Reactor Innovative Small Module (PRISM), the NRC/Advisory Committee on Reactor Safeguards (ACRS) raised numerous safety-related issues regarding elevated-temperature structural integrity criteria. Most of these issues remained unresolved today. These critical licensing reviews provide a basis for the evaluation of underlying technical issues for future advanced sodium-cooled reactors. Major materials performance issues and high temperature design methodology issues pertinent to the ARR are addressed in the report. The report is organized as follows: the ARR reference design concepts proposed by the Argonne National Laboratory and four industrial consortia were reviewed first, followed by a summary of the major code qualification and licensing issues for the ARR structural materials. The available database is presented for the ASME Code-qualified structural alloys (e.g. 304, 316 stainless steels, 2.25Cr-1Mo, and mod.9Cr-1Mo), including physical properties, tensile properties, impact properties and fracture toughness, creep, fatigue, creep-fatigue interaction, microstructural stability during long-term thermal aging, material degradation in sodium environments and effects of neutron irradiation for both base metals and weld metals. An assessment of modified versions of Type 316 SS, i.e. Type 316LN and its Japanese version, 316FR, was conducted to provide a perspective for codification of 316LN or 316FR in Subsection NH. Current status and data availability of four new advanced alloys, i.e. NF616, NF616+TMT, NF709, and HT-UPS, are also addressed to identify the R&D needs for their code qualification for ARR applications. For both conventional and new alloys, issues related to high temperature design methodology are described to address the needs for improvements for the ARR design and licensing. Assessments have shown that there are significant data gaps for the full qualification and licensing of the ARR structural materials. Development and evaluation of structural materials require a variety of experimental facilities that have been seriously degraded in the past. The availability and additional needs for the key experimental facilities are summarized at the end of the report. Detailed information covered in each Chapter is given.« less

Update on the First Cloned Dog and Outlook for Canine Cloning.

PubMed

Jang, Goo; Lee, ByeongChun

2015-10-01

As man's best friend, dogs have an important position in human society. Ten years ago, we reported the first cloned dog, and his birth has raised various scientific issues, such as those related to health, reproduction, and life span. He has developed without any unique health issues. In this article, we summarize and present perspectives on canine cloning.

State of the States 2002: GLSEN's Policy Analysis of Lesbian, Gay, Bisexual and Transgender (LGBT) Safer Schools Issues.

ERIC Educational Resources Information Center

Bauer, Allison F.

This report presents current information available on each state and the District of Columbia related to education issues that affect lesbian, gay, bisexual, and transgender (LGBT) youth. It summarizes the laws affecting students, LGBT students. Results from the 2001 National School Climate Survey of the Gay, Lesbian and Straight Education Network…