27 CFR 9.55 - Bell Mountain.

Code of Federal Regulations, 2010 CFR

2010-04-01

... following boundary description is the summit of Bell Mountain (1,956 feet). (2) Boundary Description. (i) From the starting point, the boundary proceeds due southward for exactly one half mile; (ii) Then..., where marked with an elevation of 1,773 feet; (iii) Then generally southward along Willow City Loop Road...

27 CFR 9.55 - Bell Mountain.

Code of Federal Regulations, 2014 CFR

2014-04-01

... following boundary description is the summit of Bell Mountain (1,956 feet). (2) Boundary Description. (i) From the starting point, the boundary proceeds due southward for exactly one half mile; (ii) Then..., where marked with an elevation of 1,773 feet; (iii) Then generally southward along Willow City Loop Road...

27 CFR 9.55 - Bell Mountain.

Code of Federal Regulations, 2012 CFR

2012-04-01

... following boundary description is the summit of Bell Mountain (1,956 feet). (2) Boundary Description. (i) From the starting point, the boundary proceeds due southward for exactly one half mile; (ii) Then..., where marked with an elevation of 1,773 feet; (iii) Then generally southward along Willow City Loop Road...

Mass intrusion beneath Kilauea Volcano, Hawaii, constraints from gravity and geodetic measurements (1975-2008)

NASA Astrophysics Data System (ADS)

Bagnardi, M.; Eggers, A.; Battaglia, M.; Poland, M.; Johnson, D.

2008-12-01

Since January 3 1983, Kilauea Volcano, Hawaii, has erupted almost continuously from vents on the volcano's east rift zone. On March 19, 2008, an explosion at Halema'uma'u Crater, within the summit caldera of Kilauea, marked the opening of a second eruptive vent on the volcano. The east rift vent at Pu'u'O'o and the summit vent at Halema'uma'u continue to be active as of August 2008, marking the longest interval in Kilauea's recorded history of eruptive activity on the volcano. Four gravity surveys with a network covering Kilauea's summit area have been performed during 1975-2003. We reoccupied this 45-station network in January and July 2008 with three portable LaCoste-Romberg gravimeters (G209, G615 and EG026) using a double-looping procedure. These two most recent gravity surveys span the onset of summit eruptive activity. The micro-gravity data set, combined with existing geodetic data from leveling, GPS, EDM, and InSAR, allow us to investigate and model the shallow magma system under the summit caldera to roughly constrain its shape, position, volume change and density, and better understand its long and short term evolution. We corrected for the effect of vertical deformation on gravity data (the so-called free-air effect) using uplift measurements from annual surveys performed by the USGS Hawaiian Volcano Observatory. Preliminary analysis of this record, which covers more than 30 years, indicates a persistent positive residual gravity anomaly located at the southeast margin of Halema'uma'u Crater, very close to the location of the new summit eruptive vent. This anomaly suggests a long term mass accumulation beneath the summit caldera.

9. STONE SLAB CULVERT UNDER CARRIAGE ROAD AT HORSESHOE CURVE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. STONE SLAB CULVERT UNDER CARRIAGE ROAD AT HORSESHOE CURVE NEAR GIANT SLIDE TRAIL MARKER ON AROUND-THE-MOUNTAIN LOOP. - Rockefeller Carriage Roads, Mount Desert Island, Bar Harbor, Hancock County, ME

Development and demonstration of a flutter-suppression system using active controls. [wind tunnel tests

NASA Technical Reports Server (NTRS)

Sandford, M. C.; Abel, I.; Gray, D. L.

1975-01-01

The application of active control technology to suppress flutter was demonstrated successfully in the transonic dynamics tunnel with a delta-wing model. The model was a simplified version of a proposed supersonic transport wing design. An active flutter suppression method based on an aerodynamic energy criterion was verified by using three different control laws. The first two control laws utilized both leading-edge and trailing-edge active control surfaces, whereas the third control law required only a single trailing-edge active control surface. At a Mach number of 0.9 the experimental results demonstrated increases in the flutter dynamic pressure from 12.5 percent to 30 percent with active controls. Analytical methods were developed to predict both open-loop and closed-loop stability, and the results agreed reasonably well with the experimental results.

Geology along Mosca Pass Trail, Great Sand Dunes National Park and Preserve, Colorado

USGS Publications Warehouse

Lindsey, David A.; Klein, Terry L.; Valdez, Andrew; Webster, Robert J.

2012-01-01

Mosca Pass Trail takes the hiker on a journey into the Earth's crust. Here you can see the results of tremendous tectonic forces that bend and tear rocks apart and raise mountain ranges. The trail begins near the Sangre de Cristo fault, which separates the Sangre de Cristo Range from the San Luis Valley. The valley is part of the Rio Grande rift, a series of fault basins extending from southern New Mexico to central Colorado, wherein the Earth's crust has been pulled apart during the last 30 million years. Thousands of feet of sediment, brought by streams mostly from the Sangre de Cristo Range, fill the San Luis Valley beneath the Great Sand Dunes. The trail ends at Mosca Pass overlooking Huerfano Park. The park is part of the larger Raton Basin, formed by compression of the Earth's crust during the Laramide orogeny, which occurred 70–40 million years ago. Massive highlands, the remnants of which are preserved in the Sangre de Cristo Range, were uplifted and pushed over the western side of the Raton Basin. Streams eroded the highland as it rose and filled the Raton Basin with sediment. After the sediment was compacted and cemented to form sedimentary rock, the Huerfano River and other streams began to excavate the basin. Over an unknown but long timespan that probably lasted millions of years, relatively soft sedimentary rocks were removed by the river to form the valley we call "Huerfano Park." Between the ends of the trail, the hiker walks through an erosional "window," or opening, into red sedimentary rocks overridden by gneiss, a metamorphic rock, during the Laramide orogeny. This window gives the hiker a glimpse into the Laramide highland of 70–40 million years ago that preceded the present-day Sangre de Cristo Range. The window is the focus of this trail guide. At the east end of the trail, near Mosca Pass, another trail follows the ridgeline south to Carbonate Mountain. Immediately after reaching the first summit above tree line, this trail crosses a narrow valley where red rocks mark an extension of the window across the range. Stunning vistas of the Sangre de Cristo Range extend north to the horizon. The uplifted range stands in sharp contrast to the San Luis Valley on the west and Huerfano Park on the east.

The structure of cytomegalovirus immune modulator UL141 highlights structural Ig-fold versatility for receptor binding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nemčovičová, Ivana; Slovak Academy of Sciences, Dúbravská cesta 9, SK 84505 Bratislava; Zajonc, Dirk M., E-mail: dzajonc@liai.org

2014-03-01

The crystal structure of Human cytomegalovirus immune modulator UL141 was solved at 3.25 Å resolution. Here, a detailed analysis of its intimate dimerization interface and the biophysical properties of its receptor (TRAIL-R2 and CD155) binding interactions are presented. Natural killer (NK) cells are critical components of the innate immune system as they rapidly detect and destroy infected cells. To avoid immune recognition and to allow long-term persistence in the host, Human cytomegalovirus (HCMV) has evolved a number of genes to evade or inhibit immune effector pathways. In particular, UL141 can inhibit cell-surface expression of both the NK cell-activating ligand CD155more » as well as the TRAIL death receptors (TRAIL-R1 and TRAIL-R2). The crystal structure of unliganded HCMV UL141 refined to 3.25 Å resolution allowed analysis of its head-to-tail dimerization interface. A ‘dimerization-deficient’ mutant of UL141 (ddUL141) was further designed, which retained the ability to bind to TRAIL-R2 or CD155 while losing the ability to cross-link two receptor monomers. Structural comparison of unliganded UL141 with UL141 bound to TRAIL-R2 further identified a mobile loop that makes intimate contacts with TRAIL-R2 upon receptor engagement. Superposition of the Ig-like domain of UL141 on the CD155 ligand T-cell immunoreceptor with Ig and ITIM domains (TIGIT) revealed that UL141 can potentially engage CD155 similar to TIGIT by using the C′C′′ and GF loops. Further mutations in the TIGIT binding site of CD155 (Q63R and F128R) abrogated UL141 binding, suggesting that the Ig-like domain of UL141 is a viral mimic of TIGIT, as it targets the same binding site on CD155 using similar ‘lock-and-key’ interactions. Sequence alignment of the UL141 gene and its orthologues also showed conservation in this highly hydrophobic (L/A)X{sub 6}G ‘lock’ motif for CD155 binding as well as conservation of the TRAIL-R2 binding patches, suggesting that these host–receptor interactions are evolutionary conserved.« less

Eruption of Shiveluch Volcano, Kamchatka, Russia

NASA Image and Video Library

2001-07-21

On the night of June 4, 2001 ASTER captured this thermal image of the erupting Shiveluch volcano. Located on Russia's Kamchatka Peninsula, Shiveluch rises to an altitude of 8028'. The active lava dome complex is seen as a bright (hot) area on the summit of the volcano. To the southwest, a second hot area is either a debris avalanche or hot ash deposit. Trailing to the west is a 25 km ash plume, seen as a cold "cloud" streaming from the summit. At least 60 large eruptions have occurred during the last 10,000 years; the largest historical eruptions were in 1854 and 1964. Because Kamchatka is located along the major aircraft routes between North America/Europe and the Far East, this area is constantly monitored for potential ash hazards to aircraft. The lower image is the same as the upper, except it has been color coded: red is hot, light greens to dark green are progressively colder, and gray/black are the coldest areas. The image is located at 56.7 degrees north latitude, 161.3 degrees east longitude. http://photojournal.jpl.nasa.gov/catalog/PIA02674

Simultaneous use of several monitoring techniques to measure visitor load, spatio-temporal distribution and social characteristics of tourists - a case study of a cable car area in the Carpathian Mountains, Tatra National Park

NASA Astrophysics Data System (ADS)

Taczanowska, Karolina; Zięba, Antoni; Brandenburg, Christiane; Muhar, Andreas; Preisel, Hemma; Hibner, Joanna; Latosinska, Barbara; Benítez, Rafael; Bolós, Vicente; Toca-Herrera, José L.; Ziobrowski, Szymon

2017-04-01

Visitor monitoring is an integrate part of the effective management of recreational and protected areas. Comprehensive information concerning volume of tourist traffic, spatial-temporal distribution of visitors in a leisure setting as well as visitor socio-demographic characteristics may support understanding human behaviour and the ongoing natural processes (trail deterioration, erosion, impact on flora and fauna). Especially, vulnerable areas that in the same time serve as tourist attractions need to be carefully investigated. One of such areas is Kasprowy Wierch (1987 m.a.s.l.) - a popular cable car destination located in the Carpathian Mountains, Tatra National Park, Poland / Slovakia. The aim of this study was to define the overall visitor load and to understand visitor behaviour in the proximity of the upper cable car station at Kasprowy Wierch. The main focus of this presentation is the comparison of the used monitoring techniques and exposing the benefit of their simultaneous application. Visitor monitoring campaign was carried out in the study area in the summer season 2014. The following data collection techniques were simultaneously applied: 1) automatic counting (Eco-Counter pyroelectric sensors), 2) manual counting; 3) on-site interviews combined with trip diaries and visitor observation 4) GPS-tracking 5) registry of cable car tickets 6) registry of entries to the national park (TPN). Between 26.06.2014 and 30.09.2014 at 7 locations a continuous automatic counting of visitors was done using pyroelectric sensors (Eco-Counter). Additionally, on 18 sampling days at 12 locations direct observations (manual counting) of visitor flows was carried out. During the sampling days tourists were interviewed in the field using structured questionnaires (PAPI survey technique, N = 2639). Survey was combined with a documentation of visitors' trip itineraries via GPS-loggers and map sketches. Totally 1250 GPS-tracks of visitors and 1351 map sketches have been collected. Between July and September 2014 a total number of 292 493 visitors moving towards Kasprowy Wierch (KW) were registered in the cable car and on recreational trails leading to KW. 80% of people used cable car, whereas 20% were using hiking trails to get to the summit and back. Cable car users with return tickets were the most numerous tourist group in the Kasprowy Wierch area. Between July and September 2014 the share of specific ticket types among cable car users was as follows: return tickets „up & down" = 59%, on-way tickets „up" = 26%, on-way tickets „down" = 15%. In the summer season 2014 on average 3179 visitors per day arrived to KW area. The maximum tourist traffic was observed in August 2014 where daily number of visitors exceded 7000. Two most intensively used path segments were located next to the upper cable car station (cable car station - Sucha Pass; cable car station - meteorological station/summit of KW). Third most heavily used path segment was located between Sucha Pass and the summit of Beskid. Visitor load at path segments located next to the cable car station was on average 5-10 times higher than the visitor load at other hiking trails in the area (e.g. trail linking Kasprowy Wierch and Czerwone Wierchy or Liliowe Pass and Świnica). Each monitoring technique allows gaining different type of information. Simultaneous use of several data collection methods has an additional added value when trying to understand tourist behaviour in the studied area. The results can be used as a basis for further investigation concerning environmental and social impacts in the Kasprowy Wierch area and may assist management of the Tatra National Park.

Wind-tunnel Investigation of High-lift and Stall-control Devices on a 37 Degree Sweptback Wing of Aspect Ratio 6 at High Reynolds Numbers

NASA Technical Reports Server (NTRS)

Koven, William; Graham, Robert R

1948-01-01

Results are presented of an investigation in the Langley 19-foot pressure tunnel of the longitudinal characteristics of a semispan model wing having 37 degrees sweepback of the leading edge, an aspect ratio of 6, and NACA 641-212 airfoil section perpendicular to the 27-percent-chord line. Several types of stall-control devices including extensible round-nose leading-edge flaps, a leading-edge slat, and a drooped leading edge were investigated; partial- and full-span trailing-edge split and double slotted flaps were also tested. In addition, various combinations of the aforementioned leading- and trailing-edge flaps were investigated. The tests covered a range of Reynolds numbers between 2.00 x 10(6) and 9.35 x 10(6). The wing with or without trailing-edge splity of double slotted flap was longitudinally unstable near maximum lift due to tip stalling. The addition of an outboard half-span leading-edge flap or a leading-edge slat to the plain wing or wing with inboard half-span split flaps eliminated tip stalling and resulted in stable moment variations at the stall. The drooped leading edge, on the other hand, was only effective when used in conjunction with an upper-surface fence. The combination of an outboard leading-edge device and inboard half-span double slotted flap resulted in an undesirable loop in the pitching-moment curve near maximum lift in spite of an inboard stall. The loop is attributed to the section characteristics of the double slotted flap. Air-flow surveys behind the wing indicated that a suitably placed horizontal tail would eliminate the loop in the moment curve.

Active load control during rolling maneuvers. [performed in the Langley Transonic Dynamics Tunnel

NASA Technical Reports Server (NTRS)

Woods-Vedeler, Jessica A.; Pototzky, Anthony S.; Hoadley, Sherwood T.

1994-01-01

A rolling maneuver load alleviation (RMLA) system has been demonstrated on the active flexible wing (AFW) wind tunnel model in the Langley Transonic Dynamics Tunnel (TDT). The objective was to develop a systematic approach for designing active control laws to alleviate wing loads during rolling maneuvers. Two RMLA control laws were developed that utilized outboard control-surface pairs (leading and trailing edge) to counteract the loads and that used inboard trailing-edge control-surface pairs to maintain roll performance. Rolling maneuver load tests were performed in the TDT at several dynamic pressures that included two below and one 11 percent above open-loop flutter dynamic pressure. The RMLA system was operated simultaneously with an active flutter suppression system above open-loop flutter dynamic pressure. At all dynamic pressures for which baseline results were obtained, torsion-moment loads were reduced for both RMLA control laws. Results for bending-moment load reductions were mixed; however, design equations developed in this study provided conservative estimates of load reduction in all cases.

Pro-apoptotic signaling induced by Retinoic acid and dsRNA is under the control of Interferon Regulatory Factor-3 in breast cancer cells.

PubMed

Bernardo, Ana R; Cosgaya, José M; Aranda, Ana; Jiménez-Lara, Ana M

2017-07-01

Breast cancer is one of the most lethal malignancies for women. Retinoic acid (RA) and double-stranded RNA (dsRNA) are considered signaling molecules with potential anticancer activity. RA, co-administered with the dsRNA mimic polyinosinic-polycytidylic acid (poly(I:C)), synergizes to induce a TRAIL (Tumor-Necrosis-Factor Related Apoptosis-Inducing Ligand)- dependent apoptotic program in breast cancer cells. Here, we report that RA/poly(I:C) co-treatment, synergically, induce the activation of Interferon Regulatory Factor-3 (IRF3) in breast cancer cells. IRF3 activation is mediated by a member of the pathogen recognition receptors, Toll-like receptor-3 (TLR3), since its depletion abrogates IRF3 activation by RA/poly(I:C) co-treatment. Besides induction of TRAIL, apoptosis induced by RA/poly(I:C) correlates with the increased expression of pro-apoptotic TRAIL receptors, TRAIL-R1/2, and the inhibition of the antagonistic receptors TRAIL-R3/4. IRF3 plays an important role in RA/poly(I:C)-induced apoptosis since IRF3 depletion suppresses caspase-8 and caspase-3 activation, TRAIL expression upregulation and apoptosis. Interestingly, RA/poly(I:C) combination synergizes to induce a bioactive autocrine/paracrine loop of type-I Interferons (IFNs) which is ultimately responsible for TRAIL and TRAIL-R1/2 expression upregulation, while inhibition of TRAIL-R3/4 expression is type-I IFN-independent. Our results highlight the importance of IRF3 and type-I IFNs signaling for the pro-apoptotic effects induced by RA and synthetic dsRNA in breast cancer cells.

77 FR 55452 - Lynn Canal-Icy Strait Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-10

... infrastructure (roads & trails), implementing stewardship objectives that enhance forested ecosystems, and/or... room, Admirality National Monument Office, 8510 Mendenhall Loop Road, Juneau, AK 99801. The public may attend the meeting via Video Teleconference (VTC) at the Hoonah Ranger District office, 430A Airport Road...

Trailed vorticity modeling for aeroelastic wind turbine simulations in stand still

DOE PAGES

Pirrung, Georg; Madsen, Helge; Schreck, Scott

2016-10-03

Current fast aeroelastic wind turbine codes suitable for certification lack an induction model for standstill conditions. A trailed vorticity model previously used as addition to a blade element momentum theory based aerodynamic model in normal operation has been extended to allow computing the induced velocities in standstill. The model is validated against analytical results for an elliptical wing in constant inflow and against stand still measurements from the NREL/NASA Phase VI unsteady experiment. The extended model obtains good results in case of the elliptical wing, but underpredicts the steady loading for the Phase VI blade in attached flow. The predictionmore » of the dynamic force coefficient loops from the Phase VI experiment is improved by the trailed vorticity modeling in both attached flow and stall in most cases. The exception is the tangential force coefficient in stall, where the codes and measurements deviate and no clear improvement is visible.« less

36 CFR 7.86 - Big Cypress National Preserve.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Road (State Road #B94). (B) The area north of Tamiami Trail. (ii) The following areas which are shown... of the Superintendent, are closed to motorized vehicles: (A) The areas between the Loop Road (State... signs, or by marking on a map which shall be available for public inspection at the office of the...

36 CFR 7.86 - Big Cypress National Preserve.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Road (State Road #B94). (B) The area north of Tamiami Trail. (ii) The following areas which are shown... of the Superintendent, are closed to motorized vehicles: (A) The areas between the Loop Road (State... signs, or by marking on a map which shall be available for public inspection at the office of the...

36 CFR 7.86 - Big Cypress National Preserve.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Road (State Road #B94). (B) The area north of Tamiami Trail. (ii) The following areas which are shown... of the Superintendent, are closed to motorized vehicles: (A) The areas between the Loop Road (State... signs, or by marking on a map which shall be available for public inspection at the office of the...

36 CFR 7.86 - Big Cypress National Preserve.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Road (State Road #B94). (B) The area north of Tamiami Trail. (ii) The following areas which are shown... of the Superintendent, are closed to motorized vehicles: (A) The areas between the Loop Road (State... signs, or by marking on a map which shall be available for public inspection at the office of the...

Closing the loop on elevation change at Summit, Greenland.

NASA Astrophysics Data System (ADS)

Hawley, R. L.; Brunt, K. M.; Neumann, T.; Waddington, E. D.

2016-12-01

Surface elevation on a large ice sheet changes due to multiplephysical processes, some of which imply mass change of the ice sheet,and some not. Accumulation of new snow, in absence of otherprocesses, will increase surface elevation as new mass is added to theice sheet. Compaction of snow and firn, both new and old, has atendency to decrease surface elevation, with no corresponding changein mass. As ice flows out to the sides on an ice sheet, conservationof mass dictates that the surface elevation will decrease,corresponding to mass loss. In response to long-term changes in mass,the continental crust on which the ice rests seeks isostatic balance,resulting (since the last glacial maximum) in an increase inelevation, with no associated mass change. The summation of theseprocesses results in net elevation change.We have measured elevation change along a 12 km transect at Summit,Greenland, monthly since 2007. Along the same transect we measuredthe burial rate of stakes to determine accumulation. We havepreviously measured firn compaction over a period of 4 years, and haverecently measured differential ice motion and the resulting strain.Over the course of the measurement period, we find no significantelevation change. We do, however, find intriguing periodicities inelevation. By combining our measurements of elevation, accumulation,firn compaction, and ice flow, we attempt to "close the loop" inattributing the long-term balance of surface elevation.

Emerging hemodynamic signatures of the right heart (Third International Right Heart Failure Summit, part 2).

PubMed

Maron, Bradley A

2014-12-01

Despite the importance of preserved right ventricular structure and function with respect to outcome across the spectrum of lung, cardiac, and pulmonary vascular diseases, only recently have organized efforts developed to consider the pulmonary vascular-right ventricular apparatus as a specific unit within the larger context of cardiopulmonary pathophysiology. The Third International Right Heart Failure Summit (Boston, MA) was a multidisciplinary event dedicated to promoting a dialogue about the scientific and clinical basis of right heart disease. The current review provides a synopsis of key discussions presented during the section of the summit titled "Emerging Hemodynamic Signatures of the Right Heart." Specifically, topics emphasized in this element of the symposium included (1) the effects of pulmonary vascular dysfunction at rest or provoked by exercise on the right ventricular pressure-volume relationship, (2) the role of pressure-volume loop analysis as a method to characterize right ventricular inefficiency and predict right heart failure, and (3) the importance of a systems biology approach to identifying novel factors that contribute to pathophenotypes associated with pulmonary arterial hypertension and/or right ventricular dysfunction. Collectively, these concepts frame a forward-thinking paradigm shift in the approach to right heart disease by emphasizing factors that regulate the transition from adaptive to maladaptive right ventricular-pulmonary vascular (patho)physiology.

Primary control of a Mach scale swashplateless rotor using brushless DC motor actuated trailing edge flaps

NASA Astrophysics Data System (ADS)

Saxena, Anand

The focus of this research was to demonstrate a four blade rotor trim in forward flight using integrated trailing edge flaps instead of using a swashplate controls. A compact brushless DC motor was evaluated as an on-blade actuator, with the possibility of achieving large trailing edge flap amplitudes. A control strategy to actuate the trailing edge flap at desired frequency and amplitude was developed and large trailing edge flap amplitudes from the motor (instead of rotational motion) were obtained. Once the actuator was tested on the bench-top, a lightweight mechanism was designed to incorporate the motor in the blade and actuate the trailing edge flaps. A six feet diameter, four bladed composite rotor with motor-flap system integrated into the NACA 0012 airfoil section was fabricated. Systematic testing was carried out for a range of load conditions, first in the vacuum chamber followed by hover tests. Large trailing edge flap deflections were observed during the hover testing, and a peak to peak trailing edge flap amplitude of 18 degree was achieved at 2000 rotor RPM with hover tip Mach number of 0.628. A closed loop controller was designed to demonstrate trailing edge flap mean position and the peak to peak amplitude control. Further, a soft pitch link was designed and fabricated, to replace the stiff pitch link and thereby reduce the torsional stiffness of the blade to 2/rev. This soft pitch link allowed for blade root pitch motion in response to the trailing edge flap inputs. Blade pitch response due to both steady as well as sinusoidal flap deflections were demonstrated. Finally, tests were performed in Glenn L. Martin wind tunnel using a model rotor rig to assess the performance of motor-flap system in forward flight. A swashplateless trim using brushless DC motor actuated trailing edge flaps was achieved for a rotor operating at 1200 RPM and an advance ratio of 0.28. Also, preliminary exploration was carried out to test the scalability of the motor driven trailing edge flap concept. In conclusion, the concept of using brushless DC motors as on-blade actuators, actuating trailing edge flaps has the potential to replace the current mechanically complex swashplate with a hydraulic-free swashplateless system and thereby reduce overall weight and hub drag.

36 CFR 7.45 - Everglades National Park.

Code of Federal Regulations, 2011 CFR

2011-07-01

... fishing services, for hire, to visitors of the park. (6) Minnow means a fish used for bait from the family... to fishing, including, but not limited to species of fish that may be taken, seasons and hours during... meridian and base, in the vicinity of Shark Valley Loop Road from Tamiami Trail south. (4) A person engaged...

36 CFR 7.45 - Everglades National Park.

Code of Federal Regulations, 2010 CFR

2010-07-01

... fishing services, for hire, to visitors of the park. (6) Minnow means a fish used for bait from the family... to fishing, including, but not limited to species of fish that may be taken, seasons and hours during... meridian and base, in the vicinity of Shark Valley Loop Road from Tamiami Trail south. (4) A person engaged...

Mike's Guiding Warmth

ERIC Educational Resources Information Center

Leckie, Linda

2010-01-01

Mike Elrick knew how to stay warm. He loved to wrap himself from head to toe in wool; the author pictures Mike as a wool-clad moccasin-footed snow walker twisting into lampwick harnesses with his trail axe looped through his belt. Mike looked forward to winter and welcomed a drop in the mercury--the lower the better! He loved the physical work of…

Shiveluch Volcano, Kamchatka Peninsula, Russia

NASA Image and Video Library

2002-01-03

On the night of June 4, 2001, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) captured this thermal image of the erupting Shiveluch volcano. Located on Russia's Kamchatka Peninsula, Shiveluch rises to an altitude of 2,447 meters (8,028 feet). The active lava dome complex is seen as a bright (hot) area on the summit of the volcano. To the southwest, a second hot area is either a debris avalanche or hot ash deposit. Trailing to the west is a 25-kilometer (15-mile) ash plume, seen as a cold "cloud" streaming from the summit. At least 60 large eruptions have occurred here during the last 10,000 years; the largest historical eruptions were in 1854 and 1964. Because Kamchatka is located along the major aircraft routes between North America/Europe and Asia, this area is constantly monitored for potential ash hazards to aircraft. The area is part of the "Ring of Fire," a string of volcanoes that encircles the Pacific Ocean. The lower image is the same as the upper, except it has been color-coded: red is hot, light greens to dark green are progressively colder, and gray/black are the coldest areas. The image is located at 56.7 degrees north latitude, 161.3 degrees east longitude. http://photojournal.jpl.nasa.gov/catalog/PIA03514

The development of a closed-loop flight controller with panel method integration for gust alleviation using biomimetic feathers on aircraft wings

NASA Astrophysics Data System (ADS)

Blower, Christopher J.; Lee, Woody; Wickenheiser, Adam M.

2012-04-01

This paper presents the development of a biomimetic closed-loop flight controller that integrates gust alleviation and flight control into a single distributed system. Modern flight controllers predominantly rely on and respond to perturbations in the global states, resulting in rotation or displacement of the entire aircraft prior to the response. This bio-inspired gust alleviation system (GAS) employs active deflection of electromechanical feathers that react to changes in the airflow, i.e. the local states. The GAS design is a skeletal wing structure with a network of featherlike panels installed on the wing's surfaces, creating the airfoil profile and replacing the trailing-edge flaps. In this study, a dynamic model of the GAS-integrated wing is simulated to compute gust-induced disturbances. The system implements continuous adjustment to flap orientation to perform corrective responses to inbound gusts. MATLAB simulations, using a closed-loop LQR integrated with a 2D adaptive panel method, allow analysis of the morphing structure's aerodynamic data. Non-linear and linear dynamic models of the GAS are compared to a traditional single control surface baseline wing. The feedback loops synthesized rely on inertial changes in the global states; however, variations in number and location of feather actuation are compared. The bio-inspired system's distributed control effort allows the flight controller to interchange between the single and dual trailing edge flap profiles, thereby offering an improved efficiency to gust response in comparison to the traditional wing configuration. The introduction of aero-braking during continuous gusting flows offers a 25% reduction in x-velocity deviation; other flight parameters can be reduced in magnitude and deviation through control weighting optimization. Consequently, the GAS demonstrates enhancements to maneuverability and stability in turbulent intensive environments.

Optimization of an Aeroservoelastic Wing with Distributed Multiple Control Surfaces

NASA Technical Reports Server (NTRS)

Stanford, Bret K.

2015-01-01

This paper considers the aeroelastic optimization of a subsonic transport wingbox under a variety of static and dynamic aeroelastic constraints. Three types of design variables are utilized: structural variables (skin thickness, stiffener details), the quasi-steady deflection scheduling of a series of control surfaces distributed along the trailing edge for maneuver load alleviation and trim attainment, and the design details of an LQR controller, which commands oscillatory hinge moments into those same control surfaces. Optimization problems are solved where a closed loop flutter constraint is forced to satisfy the required flight margin, and mass reduction benefits are realized by relaxing the open loop flutter requirements.

An experimental study of airfoil instability tonal noise with trailing edge serrations

NASA Astrophysics Data System (ADS)

Chong, Tze Pei; Joseph, Phillip F.

2013-11-01

This paper presents an experimental study of the effect of trailing edge serrations on airfoil instability noise. Detailed aeroacoustic measurements are presented of the noise radiated by an NACA-0012 airfoil with trailing edge serrations in a low to moderate speed flow under acoustical free field conditions. The existence of a separated boundary layer near the trailing edge of the airfoil at an angle of attack of 4.2 degree has been experimentally identified by a surface mounted hot-film arrays technique. Hot-wire results have shown that the saw-tooth surface can trigger a bypass transition and prevent the boundary layer from becoming separated. Without the separated boundary layer to act as an amplifier for the incoming Tollmien-Schlichting waves, the intensity and spectral characteristic of the radiated tonal noise can be affected depending upon the serration geometry. Particle Imaging Velocimetry (PIV) measurements of the airfoil wakes for a straight and serrated trailing edge are also reported in this paper. These measurements show that localized normal-component velocity fluctuations that are present in a small region of the wake from the laminar airfoil become weakened once serrations are introduced. Owing to the above unique characteristics of the serrated trailing edges, we are able to further investigate the mechanisms of airfoil instability tonal noise with special emphasis on the assessment of the wake and non-wake based aeroacoustic feedback models. It has been shown that the instability tonal noise generated at an angle of attack below approximately one degree could involve several complex mechanisms. On the other hand, the non-wake based aeroacoustic feedback mechanism alone is sufficient to predict all discrete tone frequencies accurately when the airfoil is at a moderate angle of attack. Larger Δf, which is defined as (fn+1-fn). In other words, a larger margin of velocity increase is required in order to "shift" the fn and fn+1 across fs sequentially, which is the condition for a ladder jump to occur. Lower amplification factor A for the T-S waves, which can result in a radiation of lower noise levels for the broadband hump peak at fs. This phenomenon will proportionally reduce the noise level difference for fn and fn+1, thus making an identification of a ladder jump event more difficult. Finally, we believe that the tone noise generated in this experimental study is of genuine tones of an isolated airfoil. This can be supported by the fact that, when considering either a straight trailing edge or a serrated trailing edge, the overall airfoil geometry at the same angle of attack is still retained and the wind tunnel setup and locations of the laboratory equipment, which could potentially become an anchor point for the acoustic feedback loop, are exactly the same. However, the straight S0 and serrated S2" trailing edges have been shown to produce systematically different spectral characteristics, especially in the forms of tonal rungs, which can be predicted accurately by the original and slightly modified acoustic feedback Model A respectively. In summary, the trailing edge serration is a useful device for the suppression of airfoil instability self-noise. For greater control effectiveness, however, the laminar separation bubble must be situated within the serration region of the trailing edge. This connection imposes restrictions on the angle of attack and velocity over which trailing edge serrations are effective. The feedback loop structure about the wake noise source and the suction surface of the airfoil in Model B is ignored in the present case. This assumption should be reasonably valid given that, in our previous study [3], we cannot identify any significant role of the boundary layer flow at the suction surface in contributing the instability tonal noise radiation across a wide range of Reynolds numbers.

Eigenspace techniques for active flutter suppression

NASA Technical Reports Server (NTRS)

Garrard, William L.; Liebst, Bradley S.; Farm, Jerome A.

1987-01-01

The use of eigenspace techniques for the design of an active flutter suppression system for a hypothetical research drone is discussed. One leading edge and two trailing edge aerodynamic control surfaces and four sensors (accelerometers) are available for each wing. Full state control laws are designed by selecting feedback gains which place closed loop eigenvalues and shape closed loop eigenvectors so as to stabilize wing flutter and reduce gust loads at the wing root while yielding accepatable robustness and satisfying constrains on rms control surface activity. These controllers are realized by state estimators designed using an eigenvalue placement/eigenvector shaping technique which results in recovery of the full state loop transfer characteristics. The resulting feedback compensators are shown to perform almost as well as the full state designs. They also exhibit acceptable performance in situations in which the failure of an actuator is simulated.

Optimal perturbations of a finite-width mixing layer near the trailing edge

NASA Astrophysics Data System (ADS)

Gumbart, James C.; Rabchuk, James

2002-03-01

The trailing edge of a surface separating two fluid flows can act as an efficient receptor for acoustic or other disturbances. The incident wave energy is converted by a linear mechanism into incipient flow instabilities which lead further downstream to the transition to turbulence. Understanding this process is essential for analyzing feedback loops and other resonances which can cause unwanted structural vibrations in the surface material or directed acoustic emissions from the mixing region. Previously, the modes of instability in a finite-width mixing layer near the trailing edge were studied as a function of frequency by assuming that vorticity was continually being introduced into the flow at the trailing edge by the forcing field. It was found that the initial amplitude of the growing instability mode was a sharply decreasing function of forcing frequency, and that the initial amplitude was a minimum for the frequency at which the rate of instability growth was a maximum^1. This result has led to a study of the adjoint equation for the perturbation stream function, whose eigensolutions are known to be associated with the optimal perturbation field for the frequency of forcing leading to the greatest instability growth downstream. We have obtained these solutions for a piecewise linear velocity profile near the trailing edge using group-theoretic techniques and have shown that they are indeed optimal. We have also analyzed the nature of the physical forcing field that might produce these optimal perturbations. ^1 Rabchuk, J.A., July 2000, Physics of Fluids.

Application Development: AN Interactive, Non-Technical Perspective of the Geology and Geomorphology of the Ouray Perimeter Tail, CO.

NASA Astrophysics Data System (ADS)

Allen, H. M.; Giardino, J. R.

2015-12-01

Each year people seek respite from their busy lifestyles by traveling to state or national parks, national forests or wilderness areas. The majority of these parks were established in order to help preserve our natural heritage, including wildlife, forests, and the beauty of landscapes formed from thousands of years of geologic/geomorphologic processes. Whilst being able to enjoy the tranquility of nature, tourists are being robbed of a more in-depth experience as a result of the lack of a geologic background. One such location that attracts a large number of summer tourists is the perimeter trail in Ouray, Colorado. Located in the Southwestern portion of Colorado, Ouray is situated in the beautiful San Juan Mountain range along the "Million Dollar Highway." The Perimeter trail is a six-mile trail loop that circles the city of Ouray. The city is a very popular place for summertime tourism because of its unparalleled scenery. Ouray is situated in an area that is riddled with textbook angular unconformities, metasedimentary, sedimentary, and volcanic rocks. In the study area, The San Juans have been beautifully sculpted by an array of major faulting events, glacial activity and volcanics. With the understanding that technology is ever expanding, we think there is no better way to experience the Perimeter Trail than to have an interactive application that will be both educational as well as interesting. This application is a non-technical way of looking at the geology and geomorphology of the perimeter trail. Additionally, a paper brochure shows the most noteworthy points of interest. The brochure contains a brief geologic history of the San Juan Mountains accompanied with annotated photographs to illustrate the complex geology/geomorphology encountered on the trail. The application is based on an interactive three-dimensional map, which can be zoomed to various scales. The app hosts a locational service that uses the phone's GPS to communicate location of the hiker on the trail. This project developed a simple, yet effective application that will not only guide hikers along the trail, but also aid in educating the thousands of tourists that visit the area yearly.

Enhanced Oceanic Operations Human-In-The-Loop In-Trail Procedure Validation Simulation Study

NASA Technical Reports Server (NTRS)

Murdoch, Jennifer L.; Bussink, Frank J. L.; Chamberlain, James P.; Chartrand, Ryan C.; Palmer, Michael T.; Palmer, Susan O.

2008-01-01

The Enhanced Oceanic Operations Human-In-The-Loop In-Trail Procedure (ITP) Validation Simulation Study investigated the viability of an ITP designed to enable oceanic flight level changes that would not otherwise be possible. Twelve commercial airline pilots with current oceanic experience flew a series of simulated scenarios involving either standard or ITP flight level change maneuvers and provided subjective workload ratings, assessments of ITP validity and acceptability, and objective performance measures associated with the appropriate selection, request, and execution of ITP flight level change maneuvers. In the majority of scenarios, subject pilots correctly assessed the traffic situation, selected an appropriate response (i.e., either a standard flight level change request, an ITP request, or no request), and executed their selected flight level change procedure, if any, without error. Workload ratings for ITP maneuvers were acceptable and not substantially higher than for standard flight level change maneuvers, and, for the majority of scenarios and subject pilots, subjective acceptability ratings and comments for ITP were generally high and positive. Qualitatively, the ITP was found to be valid and acceptable. However, the error rates for ITP maneuvers were higher than for standard flight level changes, and these errors may have design implications for both the ITP and the study's prototype traffic display. These errors and their implications are discussed.

Aeroacoustic measurements on a NACA 0012 applying the Coherent Particle Velocity method

NASA Astrophysics Data System (ADS)

Plogmann, B.; Würz, W.

2013-07-01

Aeroacoustic measurements on two NACA 0012 airfoil sections with different chord length and sharp trailing edge were conducted at the Laminar Wind Tunnel (LWT) of the University of Stuttgart. The LWT is a closed test section wind tunnel with a very low turbulence level and an acoustically optimized diffusor section allowing for high-quality aerodynamic as well as aeroacoustic measurements. Trailing edge noise measurements were performed using the Coherent Particle Velocity (CPV) method, which is based on a cross-spectral analysis of two hot-wire sensor signals placed on the suction and the pressure side of the airfoil trailing edge, respectively. At high angles of attack, the cross-spectral analysis of the two sensor signals used for the measurement of the trailing edge noise can be prone to a disturbing influence of hydrodynamic fluctuations. Hence, continuous shifts in the phasing of the cross-correlation are observed mainly for low sensor distances to the trailing edge. The quantitative evaluation of the trailing edge noise predominately in the low frequency range is, therefore, considerably disturbed. A new approach is proposed, which allows for the correction of the cross-correlation function based on the averaged single wire auto-spectrum. The results are compared to measurements with increased sensor distance and show good agreement. In the following, trailing edge noise measurements were performed on a NACA 0012 airfoil in a wide range of angles of attack ( α = 0°-8°) and free-stream velocities (u_{infty} = 30{-}70 {{m/s}}). The tripped flow cases exhibit a very good consistency for the scaling of the 1/3 octave spectra based on outer variables. Moreover, a common intersection point of the sound pressure level was observed for trailing edge noise spectra measured at constant free-stream velocity and different angles of attack. In cases without boundary layer tripping, the presence of an acoustic feedback loop was observed and linked to the presence of a laminar separation bubble on the pressure side in the vicinity of the trailing edge. Finally, a comparison of the aeroacoustic measurements based on the CPV method showed reasonably good agreement with published data obtained with both a microphone array and the Coherent Output Power method in open-test section facilities.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pirrung, Georg; Madsen, Helge; Schreck, Scott

Current fast aeroelastic wind turbine codes suitable for certification lack an induction model for standstill conditions. A trailed vorticity model previously used as addition to a blade element momentum theory based aerodynamic model in normal operation has been extended to allow computing the induced velocities in standstill. The model is validated against analytical results for an elliptical wing in constant inflow and against stand still measurements from the NREL/NASA Phase VI unsteady experiment. The extended model obtains good results in case of the elliptical wing, but underpredicts the steady loading for the Phase VI blade in attached flow. The predictionmore » of the dynamic force coefficient loops from the Phase VI experiment is improved by the trailed vorticity modeling in both attached flow and stall in most cases. The exception is the tangential force coefficient in stall, where the codes and measurements deviate and no clear improvement is visible.« less

Hierarchical random walks in trace fossils and the origin of optimal search behavior

PubMed Central

Sims, David W.; Reynolds, Andrew M.; Humphries, Nicolas E.; Southall, Emily J.; Wearmouth, Victoria J.; Metcalfe, Brett; Twitchett, Richard J.

2014-01-01

Efficient searching is crucial for timely location of food and other resources. Recent studies show that diverse living animals use a theoretically optimal scale-free random search for sparse resources known as a Lévy walk, but little is known of the origins and evolution of foraging behavior and the search strategies of extinct organisms. Here, using simulations of self-avoiding trace fossil trails, we show that randomly introduced strophotaxis (U-turns)—initiated by obstructions such as self-trail avoidance or innate cueing—leads to random looping patterns with clustering across increasing scales that is consistent with the presence of Lévy walks. This predicts that optimal Lévy searches may emerge from simple behaviors observed in fossil trails. We then analyzed fossilized trails of benthic marine organisms by using a novel path analysis technique and find the first evidence, to our knowledge, of Lévy-like search strategies in extinct animals. Our results show that simple search behaviors of extinct animals in heterogeneous environments give rise to hierarchically nested Brownian walk clusters that converge to optimal Lévy patterns. Primary productivity collapse and large-scale food scarcity characterizing mass extinctions evident in the fossil record may have triggered adaptation of optimal Lévy-like searches. The findings suggest that Lévy-like behavior has been used by foragers since at least the Eocene but may have a more ancient origin, which might explain recent widespread observations of such patterns among modern taxa. PMID:25024221

Vertical Profile of Aerosol Properties at Pico Mountain, Azores

NASA Astrophysics Data System (ADS)

Wright, K.; Mazzoleni, C.; Mazzoleni, L. R.; Dzepina, K.; Hueber, J.; China, S.; Sharma, N.

2013-12-01

Pico Mountain (2325m asl) is a dormant volcano in the archipelago of the Azores1500 km west of Lisbon, Portugal in the North Atlantic. It differs from typical mountain ranges such as the Alps or the Rockies, which are large and present a complex orography. Pico Mountain has a simple cone-like structure with only one main peak and is thousands of kilometers away from any other significant mountain range. In summer months, it is typical for air masses to move around the mountain rather than traveling up its face. This implies that often the peak of the mountain lies above the marine boundary layer in the free troposphere, while the lower part of the mountain is affected by marine clouds and marine air-masses. An atmospheric monitoring station, the Pico Mountain Observatory was established in 2001 in the summit caldera of the volcano at 2225m above sea level. The observatory is far from large populations or pollution sources, which makes the station ideal to study atmospheric gases and aerosols transported over long-ranges in the free troposphere. The station is reachable only by foot following a steep and strenuous hiking trail. In the summer of 2013 we began to collect vertical profiles of aerosol by carrying an instrumented backpack up to the summit of the mountain, with the goal of studying the vertical structure of atmospheric aerosols from the marine boundary layer to the free troposphere. The backpack was carried from the base of trail at 1200m asl. The backpack was equipped with the following instruments: 1. Nephelometer to measure light scattering from aerosol 2. 2-size optical particle counter (300-500 nm) 3. Portable micro-aethalometer to measure absorbing aerosols 4. SEM/TEM sampler to collect particles for off-line electron microscopy analysis 5. Battery powered data logger to measure relative humidity, temperature and pressure 6. GPS tracking device We provide a preliminary analysis of data collected in 2013 to gain insight on the vertical distribution of aerosol properties in a marine environment from the boundary layer to the free troposphere. The analysis of these data will help us understand the role of aerosol aging, vertical transport and distribution in a marine environment.

Sports and Recreation

NASA Technical Reports Server (NTRS)

1977-01-01

Among a number of solar energy tests being jointly conducted by NASA's Lewis Research Center and the Energy Research and Development Administration are a sun-powered refrigerator and a back-pack mounted power supply for radios. Both use solar cells, spacecraft power sources which convert sun energy into electricity. The refrigerator, which has potential utility for outdoor campers, is in operation at a trail construction camp in Isle Royale National Park, a remote wilderness in Michigan's Lake Superior where electricity is available only at park headquarters. Trail maintenance crews working in the back country get food supplies only once weekly; with refrigeration they can enjoy a more varied and nutritious diet. Solar cells provide power to run the refrigerator and to charge its batteries for an alternate power supply when sun is not available. At the request of Znyo National Forest personnel NASA-Lewis also developed a back-pack system. The lightweight solar cell pack (on the pack strap in photo) charges batteries for portable two-way radios used by trailguards, who are on patrol for as much as two weeks at a time. Guards want continuous communication with the District Station, but battery capacity precludes such operation. With the solar cell power supply, guards can use their radios 24 hours a day.A lightweight, higher-capacity oxygen bottle-derived from rocket propellant tank technology-proved an important aid in the 1976 ascent to the summit of Mt. Everest by members of the. American Bicentennial Everest Expedition.

Effect of using poles on foot-ground kinetics during stance phase in trail running.

PubMed

Daviaux, Yannick; Hintzy, Frédérique; Samozino, Pierre; Horvais, Nicolas

2013-01-01

The aim of this study was to investigate the effect of using poles on foot-ground interaction during trail running with slopes of varying incline. Ten runners ran on a loop track representative of a trail running field situation with uphill (+9°), level and downhill (-6°) sections at fixed speed (3.2 m.s(-1)). Experimental conditions included running with (WP) and without (NP) the use of poles for each of the three slopes. Several quantitative and temporal foot-ground interaction parameters were calculated from plantar pressure data measured with a portable device. Using poles induced a decrease in plantar pressure intensity even when the running velocity stayed constant. However, the localisation and the magnitude of this decrease depended on the slope situations. During WP level running, regional analysis of the foot highlighted a decrease of the force time integral (FTI) for absolute (FTIabs; -12.6%; P<0.05) and relative values (FTIrel; -14.3%; P<0.05) in the medial forefoot region. FTIabs (-14.2%; P<0.05) and duration of force application (Δt; -13.5%; P<0.05) also decreased in the medial heel region when WP downhill running. These results support a facilitating effect of pole use for propulsion during level running and for the absorption phase during downhill running.

Closed-loop Separation Control Using Oscillatory Flow Excitation

NASA Technical Reports Server (NTRS)

Allan, Brian G.; Juang, Jer-Nan; Raney, David L.; Seifert, Avi; Pack, latunia G.; Brown, Donald E.

2000-01-01

Design and implementation of a digital feedback controller for a flow control experiment was performed. The experiment was conducted in a cryogenic pressurized wind tunnel on a generic separated configuration at a chord Reynolds number of 16 million and a Mach number of 0.25. The model simulates the upper surface of a 20% thick airfoil at zero angle-of-attack. A moderate favorable pressure gradient, up to 55% of the chord, is followed by a severe adverse pressure gradient which is relaxed towards the trailing edge. The turbulent separation bubble, behind the adverse pressure gradient, is then reduced by introducing oscillatory flow excitation just upstream of the point of flow separation. The degree of reduction in the separation region can be controlled by the amplitude of the oscillatory excitation. A feedback controller was designed to track a given trajectory for the desired degree of flow reattachment and to improve the transient behavior of the flow system. Closed-loop experiments demonstrated that the feedback controller was able to track step input commands and improve the transient behavior of the open-loop response.

Exploratory Studies in Generalized Predictive Control for Active Gust Load Alleviation

NASA Technical Reports Server (NTRS)

Kvaternik, Raymond G.; Eure, Kenneth W.; Juang, Jer-Nan

2006-01-01

The results of numerical simulations aimed at assessing the efficacy of Generalized Predictive Control (GPC) for active gust load alleviation using trailing- and leading-edge control surfaces are presented. The equations underlying the method are presented and discussed, including system identification, calculation of control law matrices, and calculation of commands applied to the control effectors. Both embedded and explicit feedforward paths for inclusion of disturbance effects are addressed. Results from two types of simulations are shown. The first used a 3-DOF math model of a mass-spring-dashpot system subject to user-defined external disturbances. The second used open-loop data from a wind-tunnel test in which a wing model was excited by sinusoidal vertical gusts; closed-loop behavior was simulated in post-test calculations. Results obtained from these simulations have been decidedly positive. In particular, results of closed-loop simulations for the wing model showed reductions in root moments by factors as high as 1000, depending on whether the excitation is from a constant- or variable-frequency gust and on the direction of the response.

Summiteers--Moving Mountains with Bereaved Boys

ERIC Educational Resources Information Center

Renner, Hans-Georg

2011-01-01

Summiteers are people who rush to the top. There is a mountain summit and a metaphorical summit inside us which we can climb. In the area of mountain summits, Reinhold Messner is surely the best known and most successful summiteer. He climbed, among other things, the highest peak on earth without supplemental oxygen. In the language of the country…

Reduced Structural Connectivity in Frontostriatal White Matter Tracts in the Associative Loop in Schizophrenia.

PubMed

Levitt, James J; Nestor, Paul G; Levin, Laura; Pelavin, Paula; Lin, Pan; Kubicki, Marek; McCarley, Robert W; Shenton, Martha E; Rathi, Yogesh

2017-11-01

The striatum receives segregated and integrative white matter tracts from the cortex facilitating information processing in the cortico-basal ganglia network. The authors examined both types of input tracts in the striatal associative loop in chronic schizophrenia patients and healthy control subjects. Structural and diffusion MRI scans were acquired on a 3-T system from 26 chronic schizophrenia patients and 26 matched healthy control subjects. Using FreeSurfer, the associative cortex was parcellated into ventrolateral prefrontal cortex and dorsolateral prefrontal cortex subregions. The striatum was manually parcellated into its associative and sensorimotor functional subregions. Fractional anisotropy and normalized streamlines, an estimate of fiber counts, were assessed in four frontostriatal tracts (dorsolateral prefrontal cortex-associative striatum, dorsolateral prefrontal cortex-sensorimotor striatum, ventrolateral prefrontal cortex-associative striatum, and ventrolateral prefrontal cortex-sensorimotor striatum). Furthermore, these measures were correlated with a measure of cognitive control, the Trail-Making Test, Part B. Results showed reduced fractional anisotropy and fewer streamlines in chronic schizophrenia patients for all four tracts, both segregated and integrative. Post hoc t tests showed reduced fractional anisotropy in the left ventrolateral prefrontal cortex-associative striatum and left ventrolateral prefrontal cortex-sensorimotor striatum and fewer normalized streamlines in the right dorsolateral prefrontal cortex-sensorimotor striatum and in the left and right ventrolateral prefrontal cortex-sensorimotor striatum in chronic schizophrenia patients. Furthermore, normalized streamlines in the right dorsolateral prefrontal cortex-sensorimotor striatum negatively correlated with Trail-Making Test, Part B, time spent in healthy control subjects but not in chronic schizophrenia patients. These findings demonstrated that structural connectivity is reduced in both segregated and integrative tracts in the striatal associative loop in chronic schizophrenia and that reduced normalized streamlines in the right-hemisphere dorsolateral prefrontal cortex-sensorimotor striatum predicted worse cognitive control in healthy control subjects but not in chronic schizophrenia patients, suggesting a loss of a "normal" brain-behavior correlation in chronic schizophrenia.

Pilot In-Trail Procedure Validation Simulation Study

NASA Technical Reports Server (NTRS)

Bussink, Frank J. L.; Murdoch, Jennifer L.; Chamberlain, James P.; Chartrand, Ryan; Jones, Kenneth M.

2008-01-01

A Human-In-The-Loop experiment was conducted at the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC) to investigate the viability of the In-Trail Procedure (ITP) concept from a flight crew perspective, by placing participating airline pilots in a simulated oceanic flight environment. The test subject pilots used new onboard avionics equipment that provided improved information about nearby traffic and enabled them, when specific criteria were met, to request an ITP flight level change referencing one or two nearby aircraft that might otherwise block the flight level change. The subject pilots subjective assessments of ITP validity and acceptability were measured via questionnaires and discussions, and their objective performance in appropriately selecting, requesting, and performing ITP flight level changes was evaluated for each simulated flight scenario. Objective performance and subjective workload assessment data from the experiment s test conditions were analyzed for statistical and operational significance and are reported in the paper. Based on these results, suggestions are made to further improve the ITP.

Effect of control surface mass unbalance on the stability of a closed-loop active control system

NASA Technical Reports Server (NTRS)

Nissim, E.

1989-01-01

The effects on stability of inertial forces arising from closed-loop activation of mass-unbalanced control surfaces are studied analytically using inertial energy approach, similar to the aerodynamic energy approach used for flutter suppression. The limitations of a single control surface like a leading-edge (LE) control or a trailing-edge (TE) control are demonstrated and compared to the superior combined LE-TE mass unbalanced system. It is shown that a spanwise section for sensor location can be determined which ensures minimum sensitivity to the mode shapes of the aircraft. It is shown that an LE control exhibits compatibility between inertial stabilization and aerodynamic stabilization, and that a TE control lacks such compatibility. The results of the present work should prove valuable, both for the purpose of flutter suppression using mass unbalanced control surfaces, or for the stabilization of structural modes of large space structures by means of inertial forces.

Reconnection Outflows in the Extended Corona and Magnetotail

NASA Astrophysics Data System (ADS)

Savage, Sabrina; Kobelski, Adam

2017-08-01

Observational signatures of reconnection have been studied extensively in the lower corona for decades, successfully providing insight into energy release mechanisms in the region above post-flare arcade loops and below 1.5 solar radii. During large eruptive events, however, energy release continues to occur well beyond the presence of reconnection signatures at these low heights. Supra-arcade downflows (SADs) and downflowing loops (SADLs) are particularly useful measures of continual reconnection in the corona as they may indicate the presence and path of retracting post-reconnection loops. SADs and SADLs have been observed for days beyond the passage of corona mass ejections through the SOHO/LASCO field of view and for nearly a week after an eruption on 14 October 2014. The association of these features with magnetic reconnection increases the significance of understanding their genesis. SADs have been interpreted as wakes behind newly reconnected and outflowing loops (SADLs). Models have shown the plausibility of this interpretation, though this interpretation has not yet been fully accepted. We will present a preliminary study of complementary observations of magnetic reconnection detected via in situ instruments in the magnetosphere. These observations, provided by five THEMIS spacecraft, reveal similar structures and conditions to those related to SADs. We compare data from multiple SADs and dipolarization fronts to test the similarity between these plasma regimes, strongly favoring the interpretation of SADs as instabilities trailing retracting loops. We will also use these observations to strengthen the case for the development of an EUV wide-field coronal imager.

Proceedings Report from the Sustainability Education Summit, September 20-21, 2010

ERIC Educational Resources Information Center

US Department of Education, 2011

2011-01-01

The first-ever U. S. Department of Education summit on sustainability, "Sustainability Education Summit: Citizenship and Pathways for a Green Economy," was held on Sept. 20-21, 2010, in Washington, D.C. The Sustainability Education Summit (the Summit) brought together leaders from higher education, business and industry, labor,…

Carbon dioxide emission rate of Kīlauea Volcano: Implications for primary magma and the summit reservoir

USGS Publications Warehouse

Gerlach, T.M.; McGee, K.A.; Elias, T.; Sutton, A.J.; Doukas, M.P.

2002-01-01

 We report a CO2 emission rate of 8500 metric tons per day (t d−1) for the summit of Kīlauea Volcano, several times larger than previous estimates. It is based on three sets of measurements over 4 years of synchronous SO2 emission rates and volcanic CO2/SO2concentration ratios for the summit correlation spectrometer (COSPEC) traverse. Volcanic CO2/SO2 for the traverse is representative of the global ratio for summit emissions. The summit CO2 emission rate is nearly constant, despite large temporal variations in summit CO2/SO2 and SO2 emission rates. Summit CO2 emissions comprise most of Kīlauea's total CO2 output (∼9000 t d−1). The bulk CO2 content of primary magma determined from CO2emission and magma supply rate data is ∼0.70 wt %. Most of the CO2 is present as exsolved vapor at summit reservoir depths, making the primary magma strongly buoyant. Turbulent mixing with resident reservoir magma, however, prevents frequent eruptions of buoyant primary magma in the summit region. CO2 emissions confirm that the magma supply enters the edifice through the summit reservoir. A persistent several hundred parts per million CO2 anomaly arises from the entry of magma into the summit reservoir beneath a square kilometer area east of Halemaumau pit crater. Since most of the CO2 in primary magma is degassed in the summit, the summit CO2 emission rate is an effective proxy for the magma supply rate. Both scrubbing of SO2 and solubility controls on CO2and S in basaltic melt cause high CO2/SO2 in summit emissions and spatially uncorrelated distributions of CO2 and SO2 in the summit plume.

Investigation of shock-acoustic-wave interaction in transonic flow

NASA Astrophysics Data System (ADS)

Feldhusen-Hoffmann, Antje; Statnikov, Vladimir; Klaas, Michael; Schröder, Wolfgang

2018-01-01

The buffet flow field around supercritical airfoils is dominated by self-sustained shock wave oscillations on the suction side of the wing. Theories assume that this unsteadiness is driven by an acoustic feedback loop of disturbances in the flow field downstream of the shock wave whose upstream propagating part is generated by acoustic waves. Therefore, in this study, first variations in the sound pressure level of the airfoil's trailing-edge noise during a buffet cycle, which force the shock wave to move upstream and downstream, are detected, and then, the sensitivity of the shock wave oscillation during buffet to external acoustic forcing is analyzed. Time-resolved standard and tomographic particle-image velocimetry (PIV) measurements are applied to investigate the transonic buffet flow field over a supercritical DRA 2303 airfoil. The freestream Mach number is M_{∞} = 0.73, the angle of attack is α = {3.5}°, and the chord-based Reynolds number is Re_c = 1.9× 10^6. The perturbed Lamb vector field, which describes the major acoustic source term of trailing-edge noise, is determined from the tomographic PIV data. Subsequently, the buffet flow field is disturbed by an artificially generated acoustic field, the acoustic intensity of which is comparable to the Lamb vector that is determined from the PIV data. The results confirm the hypothesis that buffet is driven by an acoustic feedback loop and show the shock wave oscillation to directly respond to external acoustic forcing. That is, the amplitude modulation frequency of the artificial acoustic perturbation determines the shock oscillation.

77 FR 68117 - Blue Summit Wind, LLC; Notice of Petition for Declaratory Order

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... Wind, LLC; Notice of Petition for Declaratory Order Take notice that on November 6, 2012, pursuant to... Procedure 18 CFR 385.207(a)(2), Blue Summit Wind, LLC (Blue Summit) filed a petition for declaratory order... from the Blue Summit's wind energy generator (Blue Summit Facility) located within the Southwest Power...

Revisiting Primary Care's Critical Role in Achieving Health Equity: Pisacano Scholars' Reflections from Starfield Summit II.

PubMed

Park, Brian; Coutinho, Anastasia J; Doohan, Noemi; Jimenez, Jonathan; Martin, Sara; Romano, Max; Wohler, Diana; DeVoe, Jennifer

2018-01-01

The second Starfield Summit was held in Portland, Oregon, in April 2017. The Summit addressed the role of primary care in advancing health equity by focusing on 4 key domains: social determinants of health in primary care, vulnerable populations, economics and policy, and social accountability. Invited participants represented an interdisciplinary group of primary care clinicians, researchers, educators, policymakers, community leaders, and trainees. The Pisacano Leadership Foundation was one of the Summit sponsors and held its annual leadership symposium in conjunction with the Summit, enabling several Pisacano Scholars to attend the Summit. After the Summit, a small group of current and former Pisacano Scholars formed a writing group to highlight key themes and implications for action discussed at the Summit. The Summit resonated as a call to action for primary care to move beyond identifying existing health inequities and toward the development of interventions that advance health equity, through education, research, and enhanced community partnerships. In doing so, the Summit aimed to build on the foundational work of Dr. Starfield, challenging us to explore the significant role of primary care in truly achieving health equity. © Copyright 2018 by the American Board of Family Medicine.

47. Spring 1935 Harold J. Cook, photographer "Summit Road construction. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. Spring 1935 Harold J. Cook, photographer "Summit Road construction. Early stage of road tunnel construction, while tunnel was being driven on Summit Road, Scotts Bluff National Monument." - Scotts Bluff Summit Road, Gering, Scotts Bluff County, NE

Static and Dynamic Aeroelastic Tailoring With Variable Camber Control

NASA Technical Reports Server (NTRS)

Stanford, Bret K.

2016-01-01

This paper examines the use of a Variable Camber Continuous Trailing Edge Flap (VCCTEF) system for aeroservoelastic optimization of a transport wingbox. The quasisteady and unsteady motions of the flap system are utilized as design variables, along with patch-level structural variables, towards minimizing wingbox weight via maneuver load alleviation and active flutter suppression. The resulting system is, in general, very successful at removing structural weight in a feasible manner. Limitations to this success are imposed by including load cases where the VCCTEF system is not active (open-loop) in the optimization process, and also by including actuator operating cost constraints.

Can summits lead to curricula change? An evaluation of emergency preparedness summits for schools of nursing in Georgia.

PubMed

Buyum, Arielle; Dubruiel, Nicole; Torghele, Karen; Alperin, Melissa; Miner, Kathleen R

2009-05-01

The Emory University Center for Public Health Preparedness held two summits for nurses that were evaluated by survey. Participants cited multiple deficiencies and challenges with integrating emergency preparedness into nursing curricula. The summits and the related materials were reported as highly useful by survey respondents. More than three fourths of respondents reported incorporating emergency preparedness education into their curricula after summit attendance. Nursing professionals could use summits to encourage active practitioners to pursue continuing education and to initiate efforts to incorporate emergency preparedness and related health care issues into the curricula of schools of nursing.

Elder abuse awareness and action: the role of state summits.

PubMed

Anetzberger, Georgia J; Balaswamy, Shantha

2010-01-01

Increasingly, states are convening summits to identify appropriate local responses to elder abuse. This first-ever nationwide research on state-level elder abuse summits examines what leads to their formation, what they accomplish, and what factors contribute to their success. Study results suggest that two-fifths of the states have held summits, four-fifths of which have been since 2000. Typically the summits were convened by the state department of human services or aging, involved 25-50 participants, and lasted less than 2 years. Nearly 50% of study respondents felt that summit goals had been met, and 60% stated that recommendations were implemented, usually because of committed participants, involvement of the right people, or strong advocacy. State summits can be effective means for galvanizing collective action to address elder abuse as a complex social problem.

Bilateral subthalamic or pallidal stimulation for Parkinson's disease affects neither memory nor executive functions: a consecutive series of 62 patients.

PubMed

Ardouin, C; Pillon, B; Peiffer, E; Bejjani, P; Limousin, P; Damier, P; Arnulf, I; Benabid, A L; Agid, Y; Pollak, P

1999-08-01

There is a renewal of interest in surgical approaches including lesions and deep brain stimulation directed at motor subcorticofrontal loops. Bilateral lesioning presents a far greater risk of adverse effects, especially cognitive impairment. Furthermore, the main advantages of the stimulation procedure over lesioning are adaptability and reversibility of effects. The aim of this study was to assess the influence of bilateral stimulation of the subthalamic nucleus or internal globus pallidus on memory and executive functions in Parkinson's disease. Sixty-two patients were assessed before and after 3 to 6 months of chronic bilateral stimulation of the subthalamic nucleus (n = 49) or internal globus pallidus (n = 13). The neuropsychological tests used were the Mattis Dementia Rating Scale, the Grober and Buschke Verbal Learning Test, the Wisconsin Card Sorting Test, category and literal fluency, graphic and motor series, the Stroop Test, and the Trail Making Test. Mood was evaluated by the Beck Depression Inventory. Only 4 of 25 cognitive variables were affected by deep brain stimulation. Under stimulation, performance improved for Parts A and B of the Trail Making Test, but there was a deterioration in literal and total lexical fluency. There was also a mild but significant improvement in mood. It may therefore be concluded that stimulation of the subthalamic nucleus or internal globus pallidus does not change the overall cognitive performance in Parkinson's disease and does not greatly affect the functioning of subcorticofrontal loops involved in cognition in humans. This relative absence of cognitive impairment in bilateral deep brain stimulation is likely because of the accurate positioning of the electrodes, allowing the effects of stimulation to be confined to sensorimotor circuits.

Learning Optimized: A Conversation with Diane Tavenner

ERIC Educational Resources Information Center

Jacobs, Joanne

2013-01-01

Named Charter Leader of the Year in 2010 by the California Charter Schools Association, Diane Tavenner, CEO of Summit Public Schools, is responsible for the generation of multiple transformative schools and a radically different teaching model for Summit. Summit's first charter high school, Summit Prep, launched in 2003, was featured in the film…

Primative components, crustal assimilation, and magmatic degassing of the 2008 Kilauea summit eruption

USGS Publications Warehouse

Rowe, Michael C.; Thornber, Carl R.; Orr, Tim R.

2015-01-01

Simultaneous summit and rift zone eruptions at Kīlauea starting in 2008 reflect a shallow eruptive plumbing system inundated by a bourgeoning supply of new magma from depth. Olivine-hosted melt inclusions, host glass, and bulk lava compositions of magma erupted at both the summit and east rift zone demonstrate chemical continuity at both ends of a well-worn summit-to-rift pipeline. Analysis of glass within dense-cored lapilli erupted from the summit in March – August 2008 show these are not samplings of compositionally distinct magmas stored in the shallow summit magma reservoir, but instead result from remelting and assimilation of fragments from conduit wall and vent blocks. Summit pyroclasts show the predominant and most primitive component erupted to be a homogenous, relatively trace-element-depleted melt that is a compositionally indistinguishable from east rift lava. Based on a “top-down” model for the geochemical variation in east rift zone lava over the past 30 years, we suggest that the apparent absence of a 1982 enriched component in melt inclusions, as well as the proposed summit-rift zone connectivity based on sulfur and mineral chemistry, indicate that the last of the pre-1983 magma has been flushed out of the summit reservoir during the surge of mantle-derived magma from 2003-2007.

The Meta-Leadership Summit for Preparedness Initiative: An Innovative Model to Advance Public Health Preparedness and Response

PubMed Central

Sobelson, Robyn K.; Young, Andrea C.; Marcus, Leonard J.; Dorn, Barry C.; Neslund, Verla S.; McNulty, Eric J.

2017-01-01

This article reports on the design, evaluation framework, and results from the Meta-Leadership Summit for Preparedness Initiative. The Meta-Leadership Summit for Preparedness was a 5-year initiative based on the premise that national preparedness and emergency response is not solely the responsibility of government. From 2006 to 2011, 36 Meta-Leadership Summits were delivered in communities across the country. Summits were customized, 10-hour leadership development, networking, and community action planning events. They included participation from targeted federal, state, local, nonprofit/philanthropic, and private sector leaders who are directly involved in decision making during a major community or state-wide emergency. A total of 4,971 government, nonprofit, and business leaders attended Meta-Leadership Summits; distribution of attendees by sector was balanced. Ninety-three percent of respondents reported the summit was a valuable use of time, 91% reported the overall quality as “good” or “outstanding,” and 91% would recommend the summit to their colleagues. In addition, approximately 6 months after attending a summit, 80% of respondents reported that they had used meta-leadership concepts or principles. Of these, 93% reported that using meta-leadership concepts or principles had made a positive difference for them and their organizations. The Meta-Leadership Summit for Preparedness Initiative was a value-added opportunity for communities, providing the venue for learning the concepts and practice of meta-leadership, multisector collaboration, and resource sharing with the intent of substantively improving preparedness, response, and recovery efforts. PMID:24251597

The meta-leadership summit for preparedness initiative: an innovative model to advance public health preparedness and response.

PubMed

Sobelson, Robyn K; Young, Andrea C; Marcus, Leonard J; Dorn, Barry C; Neslund, Verla S; McNulty, Eric J

2013-12-01

This article reports on the design, evaluation framework, and results from the Meta-Leadership Summit for Preparedness Initiative. The Meta-Leadership Summit for Preparedness was a 5-year initiative based on the premise that national preparedness and emergency response is not solely the responsibility of government. From 2006 to 2011, 36 Meta-Leadership Summits were delivered in communities across the country. Summits were customized, 10-hour leadership development, networking, and community action planning events. They included participation from targeted federal, state, local, nonprofit/philanthropic, and private sector leaders who are directly involved in decision making during a major community or state-wide emergency. A total of 4,971 government, nonprofit, and business leaders attended Meta-Leadership Summits; distribution of attendees by sector was balanced. Ninety-three percent of respondents reported the summit was a valuable use of time, 91% reported the overall quality as "good" or "outstanding," and 91% would recommend the summit to their colleagues. In addition, approximately 6 months after attending a summit, 80% of respondents reported that they had used meta-leadership concepts or principles. Of these, 93% reported that using meta-leadership concepts or principles had made a positive difference for them and their organizations. The Meta-Leadership Summit for Preparedness Initiative was a value-added opportunity for communities, providing the venue for learning the concepts and practice of meta-leadership, multisector collaboration, and resource sharing with the intent of substantively improving preparedness, response, and recovery efforts.

Relation of summit deformation to east rift zone eruptions on Kilauea Volcano, Hawaii

DOE Office of Scientific and Technical Information (OSTI.GOV)

Epp, D.; Decker, R.W.; Okamura, A.T.

1983-07-01

An inverse relationship exists between the summit deflation of Kilauea, as recorded by summit tilt, and the elevation of associated eruptive vents on the East Rift Zone. This relationship implies that East Rift eruptions drain the summit magma reservior to pressure levels that are dependent on the elevation of the eruptive vents.

Defense.gov Special Report: NATO 25th Summit Meeting

Science.gov Websites

Representatives from 60 countries and organizations are participating in the 25th NATO summit in Chicago - the said at the conclusion of the alliance's summit in Chicago. Story NATO Secretary General Terms Summit a Chicago have accomplished what they set out to do, NATO Secretary General Anders Fogh Rasmussen said

An Assessment of Magnetic Conditions for Strong Coronal Heating in Solar Active Regions by Comparing Observed Loops with Computed Potential Field Lines

NASA Technical Reports Server (NTRS)

Gary, G. A.; Moore, R. L.; Porter, J. G.; Falconer, D. A.

1999-01-01

We report further results on the magnetic origins of coronal heating found from registering coronal images with photospheric vector magnetograms. For two complementary active regions, we use computed potential field lines to examine the global non-potentiality of bright extended coronal loops and the three-dimensional structure of the magnetic field at their feet, and assess the role of these magnetic conditions in the strong coronal heating in these loops. The two active regions are complementary, in that one is globally potential and the other is globally nonpotential, while each is predominantly bipolar, and each has an island of included polarity in its trailing polarity domain. We find the following: (1) The brightest main-arch loops of the globally potential active region are brighter than the brightest main- arch loops of the globally strongly nonpotential active region. (2) In each active region, only a few of the mainarch magnetic loops are strongly heated, and these are all rooted near the island. (3) The end of each main-arch bright loop apparently bifurcates above the island, so that it embraces the island and the magnetic null above the island. (4) At any one time, there are other main-arch magnetic loops that embrace the island in the same manner as do the bright loops but that are not selected for strong coronal heating. (5) There is continual microflaring in sheared core fields around the island, but the main-arch bright loops show little response to these microflares. From these observational and modeling results we draw the following conclusions: (1) The heating of the main-arch bright loops arises mainly from conditions at the island end of these loops and not from their global non-potentiality. (2) There is, at most, only a loose coupling between the coronal heating in the bright loops of the main arch and the coronal heating in the sheared core fields at their feet, although in both the heating is driven by conditions/events in and around the island. (3) The main-arch bright loops are likely to be heated via reconnection driven at the magnetic null over the island. The details of how and where (along the null line) the reconnection is driven determine which of the split-end loops are selected for strong heating. (4) The null does not appear to be directly involved in the heating of the sheared core fields or in the heating of an extended loop rooted in the island. Rather, these all appear to be heated by microflares in the sheared core field.

Operational and Research Musculoskeletal Summit: Summit Recommendations

NASA Technical Reports Server (NTRS)

Scheuring, Richard A.; Walton, Marlei; Davis-Street, Janis; Smaka, Todd J.; Griffin, DeVon

2006-01-01

The Medical Informatics and Health Care Systems group in the Office of Space Medicine at NASA Johnson Space Center (JSC) has been tasked by NASA with improving overall medical care on the International Space Station (ISS) and providing insights for medical care for future exploration missions. To accomplish this task, a three day Operational and Research Musculoskeletal Summit was held on August 23-25th, 2005 at Space Center Houston. The purpose of the summit was to review NASA#s a) current strategy for preflight health maintenance and injury screening, b) current treatment methods in-flight, and c) risk mitigation strategy for musculoskeletal injuries or syndromes that could occur or impact the mission. Additionally, summit participants provided a list of research topics NASA should consider to mitigate risks to astronaut health. Prior to the summit, participants participated in a web-based pre-summit forum to review the NASA Space Medical Conditions List (SMCL) of musculoskeletal conditions that may occur on ISS as well as the resources currently available to treat them. Data from the participants were compiled and integrated with the summit proceedings. Summit participants included experts from the extramural physician and researcher communities, and representatives from NASA Headquarters, the astronaut corps, JSC Medical Operations and Human Adaptations and Countermeasures Offices, Glenn Research Center Human Research Office, and the Astronaut Strength, Conditioning, and Reconditioning (ASCR) group. The recommendations in this document are based on a summary of summit discussions and the best possible evidence-based recommendations for musculoskeletal care for astronauts while on the ISS, and include recommendati ons for exploration class missions.

CO2 Degassing at Kilauea Volcano: Implications for Primary Magma, Summit Reservoir Dynamics, and Magma Supply Monitoring

NASA Astrophysics Data System (ADS)

Gerlach, T. M.; McGee, K. A.; Elias, T.; Sutton, A. J.; Doukas, M. P.

2001-12-01

We report a new CO2 emission rate of 8,500 tons/day (t/d) for the summit of Kilauea Volcano, a result several times larger than previous estimates. It is based on 12 experiments on three occasions over four years constraining the SO2 emission rate and the average CO2/SO2 of emissions along the 5.4-km summit COSPEC traverse (by COSPEC, NDIR CO2 analyzer, and CP-FTIR). The core of the summit plume is at ground level along the traverse and gives average CO2/SO2 values that are representative of the overall summit emission, even though CO2 and SO2 variations are commonly uncorrelated. CO2 and SO2 concentrations exceed background by 200-1,000 ppm and 1-7 ppm respectively. Nighttime measurements exclude Park auto exhaust as a source of CO2. The summit CO2 emission rate is nearly constant (95% confidence interval = 300 t/d), despite variable summit SO2 emission rates (62-240 t/d) and CO2/SO2 (54-183). Including other known CO2 emissions on the volcano (mainly from the Pu`u `O`o eruption) gives a total emission rate of about 8,800 t/d. Thus summit CO2 emissions comprise 97% of the total known CO2 output, consistent with the hypothesis that all primary magma supplied to Kilauea arrives under the summit caldera and is thoroughly degassed of excess CO2. A persistent large CO2 anomaly of 200-1,000 ppm indicates the entry to the summit reservoir is beneath a km2-area east of Halemaumau. The bulk CO2 content of primary magma is about 0.70 wt%, inferred from the CO2 emission rate and Kilauea's magma supply rate (0.18 km3/y [Cayol et al., Science, 288, 2343, 2000]). Most of the CO2 is present as exsolved vapor (3.6-11.7 vol%) at summit reservoir depths (2-7 km), making the primary magma strongly buoyant. Magma chamber replenishment models show that robust turbulent mixing of primary and reservoir magma prevents frequent eruption of buoyant primary magma in the summit region. The escape of 90-95% of the CO2 from the summit reservoir provides a potential proxy for monitoring the magma supply rate. Streaming CO2-rich vapor causes fractional degassing of H2O and SO2 from reservoir magma, but scrubbing minimizes summit SO2 emissions.

The Glacier National Park GLORIA Project: A new US Target Region for Alpine Plant Monitoring Installed in the Northern Rocky Mountains, Montana

NASA Astrophysics Data System (ADS)

Holzer, K.; Fagre, D.

2004-12-01

The Global Observation Research Initiative in Alpine Environments (GLORIA) is an international research network whose purpose is to assess climate change impacts on vegetation in alpine environments worldwide. A standard protocol was developed by the international office in Vienna, Austria, and has specific site requirements and techniques that allow sites to be compared worldwide. This protocol requires four summits to be selected within a target region, covering zonal differences of subalpine to nival, and on each of these summits intensive vegetation plots are set up and monitored on a five year interval. Only three target regions in North America have been completed to date, one in Glacier National Park, Montana, and the other two in the Sierra Nevada and White Mountains, California. The four GLORIA summit plots in Glacier National Park were completed over the summers of 2003 and 2004. Because the Continental Divide bisects Glacier National Park (north to south), we chose summits only East of the divide to stay within a similar climatic pattern. Establishing sites was difficult due to the steep and rocky glaciated terrain and the remoteness of suitable sites that required multi-day approaches. Our highest summit (Seward Mtn. 2717 m) is the northernmost and our lowest summit (Dancing Lady Mtn. 2245 m) is southernmost. Treeline is strongly influenced by terrain and is significantly more variable than in the central Rocky Mountains. This also was true of zonal differences of alpine vegetation. Subalpine and even grassland species were found on the same summits as upper alpine species and areas considered subnival. While different zonal areas often occurred on one summit, they were highly influenced by the aspect and slope of that summit area. Between 51 and 82 vascular plants were documented on each summit. There was a high degree of variability in species diversity and percent cover on each summit that was correlated to directional exposure. The summit morphology caused loose vegetative associations, or micro-communities, that varied with exposure, slope angle, and substrate character. Species that exhibited dominance within the target region were Smelowskia calycina var. americana, Polemonium viscosum, Achillea millefolium, Erigeron compositus var. glabratus, and Potentilla fruticosa L. These species reflected the same variability in percent cover on the four sides of the summit areas as did the vegetation as a whole, but were present on all sides.

Reading the World: Redefining Literature and History Curriculum. A Report from the Multicultural Education Summit Convened by the San Francisco Unified School District. Proceedings (San Francisco, California, March 1998).

ERIC Educational Resources Information Center

Sandler, Susan; Maxton, Ashindi

This report documents a 1998 summit that brought together academics and practitioners to discuss the challenges of multicultural education. Part 1, "Summit Proceedings," examines definitions, major topics, voices of the summit, recommendations, and the future. Part 2, "Selected Articles," includes three sections that offer…

Youth Summits: Youth and Adults as Partners in Violence Prevention. Technical Assistance Bulletin, No. 14.

ERIC Educational Resources Information Center

Perry, George S., Jr.

Taking the position that Youth for Justice Youth Summits were highly successful in their inaugural year of 1995, this report explains the purpose and goals of the summits. The report also summarizes the activities undertaken in the 47 states (plus the District of Columbia and Puerto Rico) where the summits were held on a state-by-state basis. The…

Impacts and societal benefits of research activities at Summit Station, Greenland

NASA Astrophysics Data System (ADS)

Hawley, R. L.; Burkhart, J. F.; Courville, Z.; Dibb, J. E.; Koenig, L.; Vaughn, B. H.

2017-12-01

Summit Station began as the site for the Greenland Ice Sheet Project 2 ice core in 1989. Since then, it has hosted both summer campaign science, and since 1997, year-round observations of atmospheric and cryospheric processes. The station has been continuously occupied since 2003. While most of the science activities at the station are supported by the US NSF Office of Polar Programs, the station also hosts many interagency and international investigations in physical glaciology, atmospheric chemistry, satellite validation, astrophysics and other disciplines. Summit is the only high elevation observatory north of the Arctic circle that can provide clean air or snow sites. The station is part of the INTER-ACT consortium of Arctic research stations with the main objective to identify, understand, predict and respond to diverse environmental changes, and part of the International Arctic Systems for Observing the Atmosphere (IASOA) that coordinates Arctic research activities and provides a networked, observations-based view of the Arctic. The Summit Station Science Summit, sponsored by NSF, assembled a multidisciplinary group of scientists to review Summit Station science, define the leading research questions for Summit, and make community-based recommendations for future science goals and governance for Summit. The impact of several on-going observation records was summarized in the report "Sustaining the Science Impact of Summit Station, Greenland," including the use of station data in weather forecasts and climate models. Observations made at the station as part of long-term, year-round research or during shorter summer-only campaign seasons contribute to several of the identified Social Benefit Areas (SBAs) outlined in the International Arctic Observations Assessment Framework published by the IDA Science and Technology Policy Institute and Sustaining Arctic Observing Networks as an outcome of the 2016 Arctic Science Ministerial. The SBAs supported by research conducted at Summit include Fundamental Understanding of Arctic Systems, Infrastructure and Operations, Terrestrial and Freshwater Ecosystems and Processes and Weather and Climate. Future efforts at maintaining the station's long-term climate record will focus on these areas, as identified in the Summit Station Science Summit report.

Oximetry fails to predict acute mountain sickness or summit success during a rapid ascent to 5640 meters.

PubMed

Wagner, Dale R; Knott, Jonathan R; Fry, Jack P

2012-06-01

The purpose of this study was to determine whether arterial oxygen saturation (Spo(2)) and heart rate (HR), as measured by a finger pulse oximeter on rapid arrival to 4260 m, could be predictive of acute mountain sickness (AMS) or summit success on a climb to 5640 m. Climbers (35.0 ± 10.1 years; 51 men, 5 women) were transported from 2650 m to the Piedra Grande hut at 4260 m on Pico de Orizaba within 2 hours. After a median time of 10 hours at the hut, they climbed toward the summit (5640 m) and returned, with a median trip time of 14 hours. The Lake Louise Self-Assessment Scale (LLSS) for AMS, HR, and Spo(2) were collected on arrival at the hut and repeated immediately before and after the climbers' summit attempts. Average Spo(2) for all participants at 4260 m before their departure for the summit was 84.4% ± 3.7%. Thirty-seven of the 56 participants reached the summit, and 59% of all climbers met the criteria for AMS during the ascent. The Spo(2) was not significantly different between those who experienced AMS and those who did not (P = .82); neither was there a difference in Spo(2) between summiteers and nonsummiteers (P = .44). Climbers' HR just before the summit attempt was not related to AMS but was significantly lower for summiteers vs nonsummiteers (P = .04). The Spo(2) does not appear to be predictive of AMS or summit success during rapid ascents. Copyright © 2012 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

Geophysical observations of Kilauea volcano, Hawaii, 1. temporal gravity variations related to the 29 November, 1975, M = 7.2 earthquake and associated summit collapse

USGS Publications Warehouse

Jachens, R.C.; Eaton, G.P.

1980-01-01

Repeated high-precision gravity measurements made near the summit of Kilauea volcano, Hawaii, have revealed systematic temporal variations in the gravity field associated with a major deflation of the volcano that followed the 29 November, 1975, earthquake and eruption. Changes in the gravity field with respect to a stable reference station on the south flank of neighboring Mauna Loa volcano were measured at 18 sites in the summit region of Kilauea and at 4 sites far removed from its summit. The original survey, conducted 10-23 November, 1975, was repeated during a two-week period after the earthquake. The results indicate that sometime between the first survey and the latter part of the second survey the gravity field at sites near the summit increased with respect to that at sites far removed from the summit. The pattern of gravity increase is essentially radially symmetrical, with a half-width slightly less than 3 km, about the point of maximum change 1.5 km southeast of Halemaumau pit crater. Gravity changes at sites near the summit correlate closely with elevation decreases that occurred sometime between leveling surveys conducted in late September 1975 and early January 1976. The systematic relation between gravity and elevation change (-1.71 ?? 0.05 (s.e.) ??gal/cm) shows that deflation was accompanied by a loss of mass from beneath the summit region. Mass balance calculations indicate that for all reasonable magma densities, the volume of magma withdrawn from beneath the summit region exceeded the volume of summit collapse. Analysis suggests that magma drained from at least two distinct areas south of Kilauea caldera that coincide roughly with two reservoir areas active during inflation before the 1967-1968 Kilauea eruption. ?? 1980.

PFAS National Leadership Summit Materials

EPA Pesticide Factsheets

U.S. Environmental Protection Agency (EPA) will be hosting a National Leadership Summit in Washington, D.C. to take action on Per- and Polyfluoroalkyl Substances (PFAS) in the environment. Below are the meeting materials for the Summit.

Preparing tomorrow's transportation workforce : a Midwest summit.

DOT National Transportation Integrated Search

2010-08-01

Preparing Tomorrows Transportation Workforce: A Midwest Summit, held April 2728, 2010, in Ames, Iowa, was one of several : regional transportation workforce development summits held across the United States in 2009 and 2010 as part of a coordin...

NREL Wind Leaders Participate in Wind Industry Partnership Summit | News |

Science.gov Websites

NREL NREL Wind Leaders Participate in Wind Industry Partnership Summit NREL Wind Leaders enable innovations needed to advance U.S. wind systems. "The summit brought together leaders from

2009 National Safety Performance Function Summit

DOT National Transportation Integrated Search

2010-07-01

The Illinois Department of Transportation (IDOT) and the Illinois Center for Transportation (ICT) sponsored and : hosted the first National Safety Performance Function Summit on July 29 and 30, 2009, in Chicago, Illinois. The : goal of this summit wa...

Proceedings of Bus Summit 2000 : ensuring a healthy U.S. bus industry

DOT National Transportation Integrated Search

2000-10-01

The Federal Transit Administration (FTA) Bus Industry Summit was held October 18-19, 2000, in Washington, DC. The Summit offered an opportunity for representatives from the transit industry, including transit providers, vehicle manufacturers, consult...

1. Context view shows approach of access road to summit, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Context view shows approach of access road to summit, communication towers and NW corner of lookout tower at center right. Camera is pointed SE. - Chelan Butte Lookout, Summit of Chelan Butte, Chelan, Chelan County, WA

A dynamic balance between magma supply and eruption rate at Kilauea volcano, Hawaii

USGS Publications Warehouse

Denlinger, R.P.

1997-01-01

The dynamic balance between magma supply and vent output at Kilauea volcano is used to estimate both the volume of magma stored within Kilauea volcano and its magma supply rate. Throughout most of 1991 a linear decline in volume flux from the Kupaianaha vent on Kilauea's east rift zone was associated with a parabolic variation in the elevation of Kilauea's summit as vent output initially exceeded then lagged behind the magma supply to the volcano. The correspondence between summit elevation and tilt established with over 30 years of data provided daily estimates of summit elevation in terms of summit tilt. The minimum in the parabolic variation in summit tilt and elevation (or zero elevation change) occurs when the magma supply to the reservoir from below the volcano equals the magma output from the reservoir to the surface, so that the magma supply rate is given by vent flux on that day. The measurements of vent flux and tilt establish that the magma supply rate to Kilauea volcano on June 19, 1991, was 217,000 ?? 10,000 m3/d (or 0.079 ?? 0.004 km3/yr). This is close to the average eruptive rate of 0.08 km3/yr between 1958 and 1984. In addition, the predictable response of summit elevation and tilt to each east rift zone eruption near Puu Oo since 1983 shows that summit deformation is also a measure of magma reservoir pressure. Given this, the correlation between the elevation of the Puu Oo lava lake (4 km uprift of Kupaianaha and 18 km from the summit) and summit tilt provides an estimate for magma pressure changes corresponding to summit tilt changes. The ratio of the change in volume to the change in reservoir pressure (dV/dP) during vent activity may be determined by dividing the ratio of volume erupted to change in summit tilt (dV/dtilt) by the ratio of pressure change to change in summit tilt (dP/dtilt). This measure of dV/dP, when combined with laboratory measurements of the bulk modulus of tholeitic melt, provides an estimate of 240 ?? 50 km3 for the volume of Kilauea's magma reservoir. This estimate is much larger than traditional estimates but consistent with seismic tomographic imaging and geophysical modeling of Kilauea's magma system. Copyright 1997 by the American Geophysical Union.

A dynamic balance between magma supply and eruption rate at Kilauea volcano, Hawaii

NASA Astrophysics Data System (ADS)

Denlinger, Roger P.

1997-08-01

The dynamic balance between magma supply and vent output at Kilauea volcano is used to estimate both the volume of magma stored within Kilauea volcano and its magma supply rate. Throughout most of 1991 a linear decline in volume flux from the Kupaianaha vent on Kilauea's east rift zone was associated with a parabolic variation in the elevation of Kilauea's summit as vent output initially exceeded then lagged behind the magma supply to the volcano. The correspondence between summit elevation and tilt established with over 30 years of data provided daily estimates of summit elevation in terms of summit tilt. The minimum in the parabolic variation in summit tilt and elevation (or zero elevation change) occurs when the magma supply to the reservoir from below the volcano equals the magma output from the reservoir to the surface, so that the magma supply rate is given by vent flux on that day. The measurements of vent flux and tilt establish that the magma supply rate to Kilauea volcano on June 19, 1991, was 217,000±10,000 m3/d (or 0.079±0.004 km3/yr). This is close to the average eruptive rate of 0.08 km3/yr between 1958 and 1984. In addition, the predictable response of summit elevation and tilt to each east rift zone eruption near Puu Oo since 1983 shows that summit deformation is also a measure of magma reservoir pressure. Given this, the correlation between the elevation of the Puu Oo lava lake (4 km uprift of Kupaianaha and 18 km from the summit) and summit tilt provides an estimate for magma pressure changes corresponding to summit tilt changes. The ratio of the change in volume to the change in reservoir pressure (dV/dP) during vent activity may be determined by dividing the ratio of volume erupted to change in summit tilt (dV/dtilt) by the ratio of pressure change to change in summit tilt (dP/dtilt). This measure of dV/dP, when combined with laboratory measurements of the bulk modulus of tholeitic melt, provides an estimate of 240±50 km3 for the volume of Kilauea's magma reservoir. This estimate is much larger than traditional estimates but consistent with seismic tomographic imaging and geophysical modeling of Kilauea's magma system.

Shiveluch Volcano, Kamchatka Peninsula, Russia

NASA Technical Reports Server (NTRS)

2001-01-01

On the night of June 4, 2001, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) captured this thermal image of the erupting Shiveluch volcano. Located on Russia's Kamchatka Peninsula, Shiveluch rises to an altitude of 2,447 meters (8,028 feet). The active lava dome complex is seen as a bright (hot) area on the summit of the volcano. To the southwest, a second hot area is either a debris avalanche or hot ash deposit. Trailing to the west is a 25-kilometer (15-mile) ash plume, seen as a cold 'cloud' streaming from the summit. At least 60 large eruptions have occurred here during the last 10,000 years; the largest historical eruptions were in 1854 and 1964.

Because Kamchatka is located along the major aircraft routes between North America/Europe and Asia, this area is constantly monitored for potential ash hazards to aircraft. The area is part of the 'Ring of Fire,' a string of volcanoes that encircles the Pacific Ocean.

The lower image is the same as the upper, except it has been color-coded: red is hot, light greens to dark green are progressively colder, and gray/black are the coldest areas.

The image is located at 56.7 degrees north latitude, 161.3 degrees east longitude.

ASTER is one of five Earth-observing instruments launched Dec. 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of International Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products. The primary goal of the ASTER mission is to obtain high-resolution image data in 14 channels over the entire land surface, as well as black and white stereo images. With revisit time of between 4 and 16 days, ASTER will provide the capability for repeat coverage of changing areas on Earth's surface.

Kīlauea summit eruption—Lava returns to Halemaʻumaʻu

USGS Publications Warehouse

Babb, Janet L.; Wessells, Stephen M.; Neal, Christina A.

2017-10-06

In March 2008, a new volcanic vent opened within Halemaʻumaʻu, a crater at the summit of Kīlauea Volcano in Hawaiʻi Volcanoes National Park on the Island of Hawaiʻi. This new vent is one of two ongoing eruptions on the volcano. The other is on Kīlauea’s East Rift Zone, where vents have been erupting nearly nonstop since 1983. The duration of these simultaneous summit and rift zone eruptions on Kīlauea is unmatched in at least 200 years.Since 2008, Kīlauea’s summit eruption has consisted of continuous degassing, occasional explosive events, and an active, circulating lava lake. Because of ongoing volcanic hazards associated with the summit vent, including the emission of high levels of sulfur dioxide gas and fragments of hot lava and rock explosively hurled onto the crater rim, the area around Halemaʻumaʻu remains closed to the public as of 2017.Through historical photos of past Halemaʻumaʻu eruptions and stunning 4K imagery of the current eruption, this 24-minute program tells the story of Kīlauea Volcano’s summit lava lake—now one of the two largest lava lakes in the world. It begins with a Hawaiian chant that expresses traditional observations of a bubbling lava lake and reflects the connections between science and culture that continue on Kīlauea today.The video briefly recounts the eruptive history of Halemaʻumaʻu and describes the formation and continued growth of the current summit vent and lava lake. It features USGS Hawaiian Volcano Observatory scientists sharing their insights on the summit eruption—how they monitor the lava lake, how and why the lake level rises and falls, why explosive events occur, the connection between Kīlauea’s ongoing summit and East Rift Zone eruptions, and the impacts of the summit eruption on the Island of Hawaiʻi and beyond. The video is also available at the following U.S. Geological Survey Multimedia Gallery link (video hosted on YouTube): Kīlauea summit eruption—Lava returns to Halemaʻumaʻu

Atrial Arrhythmia Summit: Post Summit Report

NASA Technical Reports Server (NTRS)

Barr, Yael

2010-01-01

The Atrial Arrhythmia Summit brought together nationally and internationally recognized experts in cardiology, electrophysiology, exercise physiology, and space medicine in an effort to elucidate the mechanisms, risk factors, and management of atrial arrhythmias in the unique occupational cohort of the U.S. astronaut corps.

Water for Two Worlds: Designing Terrestrial Applications for Exploration-class Sanitation Systems

NASA Technical Reports Server (NTRS)

Adams, Constance; Andersson, Ingvar; Feighery, John

2004-01-01

At the United Nations Millennium Summit in September of 2000, the world leaders agreed on an ambitious agenda for reducing poverty and improving lives: the Millennium Development Goals (MDGs), a list of issues they consider highly pernicious, threatening to human welfare and, thereby, to global security and prosperity. Among the eight goals are included fundamental human needs such as the eradication of extreme poverty and hunger, the promotion of gender equality, the reduction of child mortality and improvement of maternal health, and ensuring the sustainability of our shared environment. In order to help focus the efforts to meet these goals, the United Nations (UN) has established a set of eighteen concrete targets, each with an associated schedule. Among these is Target 10: "By 2015, reduce by half the proportion of people without access to safe drinking water." A closely related target of equal dignity was agreed at the World Summit on Sustainable Development (Johannesburg, September 2002): "By 2015, reduce by half the proportion of people without access to basic sanitation." One of the greatest successes in the development of Exploration-class technologies for closed-loop, sustainable support of long-duration human space missions has been the work both ESA and NASA have done in bioregenerative water reclamation (WRS), and secondarily, in solid-waste management. Solid-waste and WRS systems tend to be combined in the commercial world into the field of sanitation, although as we will see, the most essential principles of sustainable terrestrial sanitation actually insist upon the separation of solid and liquid excreta. Seeing the potential synergy between the space program ALS technologies developed for Mars and the urgent needs of hundreds of millions of people for secure access to clean water here on Earth, we set out to organize the adaptation of these technologies to help the United Nations Development Programme (UNDP) meet Target 10. In this paper, we will summarize the issues and results of the first "Water for Two Worlds" summit held in January of this year, describe,the status of the sustainable sanitation systems that are on the table for adaptation to widespread terrestrial use, and present fundamental strategies for forward work.

Summit CO2 emission rates by the CO2/SO2 ratio method at Kīlauea Volcano, Hawaiʻi, during a period of sustained inflation

USGS Publications Warehouse

Hager, S.A.; Gerlach, T.M.; Wallace, P.J.

2008-01-01

The emission rate of carbon dioxide escaping from the summit of Kīlauea Volcano, Hawaiʻi, proved highly variable, averaging 4900 ± 2000 metric tons per day (t/d) in June–July 2003 during a period of summit inflation. These results were obtained by combining over 90 measurements of COSPEC-derived SO2emission rates with synchronous CO2/SO2 ratios of the volcanic gas plume along the summit COSPEC traverse. The results are lower than the CO2 emission rate of 8500 ± 300 t/d measured by the same method in 1995–1999 during a period of long-term summit deflation [Gerlach, T.M., McGee, K.A., Elias, T., Sutton, A.J. and Doukas, M.P., 2002. Carbon dioxide emission rate of Kīlauea Volcano: Implications for primary magma and the summit reservoir. Journal of Geophysical Research-Solid Earth, 107(B9): art. no.-2189.]. Analysis of the data indicates that the emission rates of the present study likely reflect changes in the magma supply rate and residence time in the summit reservoir. It is also likely that emission rates during the inflation period were heavily influenced by SO2 pulses emitted adjacent to the COSPEC traverse, which biased CO2/SO2 ratios towards low values that may be unrepresentative of the global summit gas plume. We conclude that the SO2 pulses are consequences of summit re-inflation under way since 2003 and that CO2 emission rates remain comparable to, but more variable than, those measured prior to re-inflation.

Determinants of heat production in newborn lambs

NASA Astrophysics Data System (ADS)

Eales, F. A.; Small, J.

1980-06-01

Measurement of summit metabolism (the maximum rate of heat production) in lambs aged 1 or 4h revealed considerable between animal variation. Summit metabolism per unit body weight decreased as body weight increased whereas summit metabolism per unit body surface area was independent of body weight. Severe pre-partum hypoxia was apparently associated with a low summit metabolism at 1 or 4h of age which made such lambs very susceptible to hypothermia. This deficiency in heat production capacity did not appear to be a permanent featuresince most lambs so affected recovered full thermoregulatory ability by 12h of age. Feeding of colostrum conferred an immediate 18% increase in summit metabolism. The significance of these findings to the prevention of hypothermia in the newborn lamb is discussed.

Variations in tilt rate and harmonic tremor amplitude during the January-August 1983 east rift eruptions of Kilauea Volcano, Hawaii

USGS Publications Warehouse

Dvorak, J.J.; Okamura, A.T.

1985-01-01

During January-August 1983, a network of telemetered tiltmeters and seismometers recorded detailed temporal changes associated with seven major eruptive phases along the east rift of Kilauea Volcano, Hawaii. Each eruptive phase was accompanied by subsidence of the summit region and followed by reinflation of the summit to approximately the same level before renewal of eruptive activity. The cyclic summit tilt pattern and the absence of measurable tilt changes near the eruptive site suggest that conditions in the summit region controlled the timing of the last six eruptive phases. The rate of summit subsidence progressively increased from one eruptive phase to the next during the last six phases; the amplitude of harmonic tremor increased during the last four phases. The increases in subsidence rate and in tremor amplitude suggest that frequent periods of magma movement have reduced the flow resistance of the conduit system between the summit and the rift zone. ?? 1985.

Radiology reporting: a closed-loop cycle from order entry to results communication.

PubMed

Weiss, David L; Kim, Woojin; Branstetter, Barton F; Prevedello, Luciano M

2014-12-01

With the increasing prevalence of PACS over the past decade, face-to-face image review among health care providers has become a rarity. This change has resulted in increasing dependence on fast and accurate communication in radiology. Turnaround time expectations are now conveyed in minutes rather than hours or even days. Ideal modern radiology communication is a closed-loop cycle with multiple interoperable applications contributing to the final product. The cycle starts with physician order entry, now often performed through the electronic medical record, with clinical decision support to ensure that the most effective imaging study is ordered. Radiology reports are now almost all in electronic format. The majority are produced using speech recognition systems. Optimization of this software use can alleviate some, if not all, of the inherent user inefficiencies in this type of reporting. Integrated third-party software applications that provide data mining capability are extremely helpful in both academic and clinical settings. The closed-loop ends with automated communication of imaging results. Software products for this purpose should facilitate use of levels of alert, automated escalation to providers, and recording of audit trails of reports received. The multiple components of reporting should be completely interoperable with each other, as well as with the PACS, the RIS, and the electronic medical record. This integration will maximize radiologist efficiency and minimize the possibility of communication error. Copyright © 2014. Published by Elsevier Inc.

27 CFR 9.67 - Catoctin.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., Maryland,” 7.5 minute series, 1953 (Photorevised 1979); (5) “Blue Ridge Summit Quadrangle, Maryland... Furnace Quadrangle,” “Blue Ridge Summit Quadrangle,” and “Emmitsburg Quadrangle” maps to the point of... the Maryland-Pennsylvania State line on the “Emmitsburg Quadrangle,” “Blue Ridge Summit Quadrangle...

27 CFR 9.67 - Catoctin.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., Maryland,” 7.5 minute series, 1953 (Photorevised 1979); (5) “Blue Ridge Summit Quadrangle, Maryland... Furnace Quadrangle,” “Blue Ridge Summit Quadrangle,” and “Emmitsburg Quadrangle” maps to the point of... the Maryland-Pennsylvania State line on the “Emmitsburg Quadrangle,” “Blue Ridge Summit Quadrangle...

27 CFR 9.67 - Catoctin.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., Maryland,” 7.5 minute series, 1953 (Photorevised 1979); (5) “Blue Ridge Summit Quadrangle, Maryland... Furnace Quadrangle,” “Blue Ridge Summit Quadrangle,” and “Emmitsburg Quadrangle” maps to the point of... the Maryland-Pennsylvania State line on the “Emmitsburg Quadrangle,” “Blue Ridge Summit Quadrangle...

27 CFR 9.67 - Catoctin.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., Maryland,” 7.5 minute series, 1953 (Photorevised 1979); (5) “Blue Ridge Summit Quadrangle, Maryland... Furnace Quadrangle,” “Blue Ridge Summit Quadrangle,” and “Emmitsburg Quadrangle” maps to the point of... the Maryland-Pennsylvania State line on the “Emmitsburg Quadrangle,” “Blue Ridge Summit Quadrangle...

27 CFR 9.67 - Catoctin.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., Maryland,” 7.5 minute series, 1953 (Photorevised 1979); (5) “Blue Ridge Summit Quadrangle, Maryland... Furnace Quadrangle,” “Blue Ridge Summit Quadrangle,” and “Emmitsburg Quadrangle” maps to the point of... the Maryland-Pennsylvania State line on the “Emmitsburg Quadrangle,” “Blue Ridge Summit Quadrangle...

11th Annual Legislative Summit, 2008

ERIC Educational Resources Information Center

National Indian Education Association, 2008

2008-01-01

Several papers were presented during the 11th Annual National Indian Education Association (NIEA) Legislative Summit. This volume contains the following briefing papers presented during the summit: (1) Reauthorization of No Child Left Behind Strengthen Native American Education; (2) The Johnson O'Malley Program; (3) Legislation to Address…

76 FR 4725 - Apria Healthcare Customer Service Department; Fourteen Locations in Missouri Cameron, Cape...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

..., Fenton, Joplin, Lee's Summit, Pleasant Valley, Poplar Bluff, Rolla, Springfield, St. Joseph, St. Peters... in Missouri: Cameron, Cape Girardeau, Columbia, Farmington, Fenton, Joplin, Lee's Summit, Pleasant..., Farmington, Fenton, Joplin, Lee's Summit, Pleasant Valley, Poplar Bluff, Rolla, Springfield, St. Joseph, St...

Flow structure of knuckling effect in footballs

NASA Astrophysics Data System (ADS)

Asai, Takeshi; Kamemoto, Kyoji

2011-07-01

The flight trajectory of a non-spinning or slow-spinning soccer ball might fluctuate in unpredictable ways, as for example, in the many free kicks of C. Ronaldo. Such anomalous horizontal shaking or rapid falling is termed the ‘knuckling effect’. However, the aerodynamic properties and boundary-layer dynamics affecting a ball during the knuckling effect are not well understood. In this study, we analyse the characteristics of the vortex structure of a soccer ball subject to the knuckling effect (knuckleball), using high-speed video images and smoke-generating agents. Two high-speed video cameras were set at one side and in front of the ball trajectory between the ball position and the goal; further, photographs were taken at 1000 fps and a resolution of 1024×512 pixels. Although in a previous study (Taneda, 1978), shedding of horseshoe vortices was observed for smooth spheres in the Reynolds number (Re) range of 3.8×105

Pacesetter in Personalized Learning

ERIC Educational Resources Information Center

Jacobs, Joanne

2017-01-01

The Chicago International Charter School (CICS) Irving Park's middle school is one of 130 schools nationwide piloting the Summit Learning Program (SLP), developed--and offered entirely free--by Summit Public Schools, a high-performing charter network based in California. Summit's eight schools, two of them in Washington State, are known for an…

Dialogue on Dialog: Interview with Roger Summit.

ERIC Educational Resources Information Center

Newman, Donald

1986-01-01

Presents interview with Roger Summit, the president of Dialog Information Services, Inc. Highlights include Summit's role as chief architect of the system, the inception of Dialog and its beginnings at Lockheed Missiles and Space Company, services provided by Dialog, a challenge for libraries, and future developments and services. (EJS)

Cotton and Sustainability: Impacting Student Learning through Sustainable Cotton Summit

ERIC Educational Resources Information Center

Ha-Brookshire, Jung; Norum, Pamela

2011-01-01

Purpose: The purpose of this paper is to examine the effect of intensive extra-curricular learning opportunities on students' knowledge, skills, and attitudes regarding cotton and sustainability. Design/methodology/approach: A three-phase extra-curricular learning opportunity was designed to include a Sustainable Cotton Summit; pre-summit and…

77 FR 6534 - Malheur National Forest; Oregon; Summit Logan Grazing Authorization Project

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-08

... Creek and Summit Prairie allotments. These allotments are within the Upper Malheur River and Upper North Fork Malheur River watersheds. The Summit Logan Grazing Authorization Project area is located south and west of Prairie City, Oregon and encompasses approximately 40,272 acres of National Forest System Lands...

2007 Youth Policy Summit Summary

ERIC Educational Resources Information Center

Reid, Ellen; Fussell, Annemarie; Templin, Elizabeth

2007-01-01

The NCSSSMST (National Consortium for Specialized Secondary Schools of Mathematics, Science and Technology) and Keystone Science School co-sponsored two Youth Policy Summits during the summer of 2007. Forty students represented 10 high schools from across the country at each Summit, meeting for a week in June and August at Keystone Science School…

78 FR 18611 - Summit on Color in Medical Imaging; Cosponsored Public Workshop; Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

...] Summit on Color in Medical Imaging; Cosponsored Public Workshop; Request for Comments AGENCY: Food and...: The Food and Drug Administration (FDA) and cosponsor International Color Consortium (ICC) are announcing the following public workshop entitled ``Summit on Color in Medical Imaging: An International...

77 FR 36549 - Nursing Workforce Diversity Invitational Summit-“Nursing in 3D: Workforce Diversity, Health...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-19

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Nursing Workforce Diversity Invitational Summit--``Nursing in 3D: Workforce Diversity, Health Disparities, and..., Division of Nursing, will host an invitational summit that focuses on Nursing Workforce Diversity (NWD...

Ebook Summit: Our Ebook Challenge

ERIC Educational Resources Information Center

Library Journal, 2010

2010-01-01

Over 2000 participants made the daylong programming at the "Library Journal"/"School Library Journal" Virtual Ebook Summit, September 29, a robust conversation and not just within the summit interface but also in tweets with the #ebooksummit hashtag (and beyond) and in libraries across the country where participants logged in to take part. The…

The Science of Eliminating Health Disparities: Summary and Analysis of the NIH Summit Recommendations

PubMed Central

Rhee, Kyu B.; Williams, Kester; Sanchez, Idalia; Sy, Francisco S.; Stinson, Nathaniel; Ruffin, John

2010-01-01

In December 2008, the National Institutes of Health (NIH) sponsored the first NIH Summit showcasing its investment and contribution to health disparities research and unveiling a framework for moving this important field forward. The Summit, titled “The Science of Eliminating Health Disparities,” drew on extensive experience of experts leading health disparities research transformation in diverse fields. The Summit also provided a historic educational opportunity to contribute to health care reform. The theme, addressing disparities through integration of science, practice, and policy, introduced a paradigm for advancing research through transformational, translational, and transdisciplinary research. Engaging active participation throughout the Summit generated recommendations bridging science, practice, and policy, including action on social determinants of health, community engagement, broad partnerships, capacity-building, and media outreach. PMID:20147660

Youth Climate Summits: Empowering & Engaging Youth to Lead on Climate Change

NASA Astrophysics Data System (ADS)

Kretser, J.

2017-12-01

The Wild Center's Youth Climate Summits is a program that engages youth in climate literacy from knowledge and understanding to developing action in their schools and communities. Each Youth Climate Summit is a one to three day event that brings students and teachers together to learn about climate change science, impacts and solutions at a global and local level. Through speakers, workshops and activities, the Summit culminates in a student-driven Climate Action Plan that can be brought back to schools and communities. The summits have been found to be powerful vehicles for inspiration, learning, community engagement and youth leadership development. Climate literacy with a focus on local climate impacts and solutions is a key component of the Youth Climate Summit. The project-based learning surrounding the creation of a unique, student driven, sustainability and Climate Action Plan promotes leadership skills applicable and the tools necessary for a 21st Century workforce. Student driven projects range from school gardens and school energy audits to working with NYS officials to commit to going 100% renewable electricty at the three state-owned downhill ski facilities. The summit model has been scaled and replicated in other communities in New York State, Vermont, Ohio, Michigan and Washington states as well as internationally in Finland, Germany and Sri Lanka.

"A Paradox Persists When the Paradigm Is Wrong": Pisacano Scholars' Reflections from the Inaugural Starfield Summit.

PubMed

Doohan, Noemi; Coutinho, Anastasia J; Lochner, Jennifer; Wohler, Diana; DeVoe, Jennifer

The inaugural Starfield Summit was hosted in April 2016 by the Robert Graham Center for Policy Studies in Family Medicine and Primary Care with additional partners and sponsors, including the Pisacano Leadership Foundation (PLF). The Summit addressed critical topics in primary care and health care delivery, including payment, measurement, and team-based care. Invited participants included an interdisciplinary group of pediatricians, family physicians, internists, behaviorists, trainees, researchers, and advocates. Among the family physicians invited were both current and past PLF (Pisacano) scholars. After the Summit, a small group of current and past Pisacano scholars formed a writing group to reflect on and summarize key lessons and conclusions from the Summit. A Summit participant's statement, "a paradox persists when the paradigm is wrong," became a repeated theme regarding the paradox of primary care within the context of the health care system in the United States. The Summit energized participants to renew their commitment to Dr. Starfield's 4 C's of Primary Care (first contact access, continuity, comprehensiveness, and care coordination) and to the Quadruple Aim (quality, value, and patient and physician satisfaction) and to continue to explore how primary care can best shape the future of the nation's health care system. © Copyright 2016 by the American Board of Family Medicine.

Observations at Kuchinoerabu-jima volcano, southern Kyushu, Japan, by using unmanned helicopter

NASA Astrophysics Data System (ADS)

Ohminato, T.; Kaneko, T.; Koyama, T.; Watanabe, A.; Kanda, W.; Tameguri, T.; Kazahaya, R.

2015-12-01

Kuchinoerabu-jima, volcano is a volcanic island located southern Kyushu, Japan. In 3 August, 2014, a small eruption at active summit crater, Shin-dake, destroyed all the observation stations near the summit. Since then, this volcano was only poorly monitored. After the eruption, entering within 2km from Shin-dake crater was strictly prohibited and thus it was impossible to fix summit stations on site. In April, 2015, we conducted seismic sensor installation by using unmanned helicopter (RMAX-G1 manufactured by Yamaha) so as to reestablish the seismic monitoring network near the summit area. We installed four seismic stations in the summit area. We also conducted various types of near-summit observations including an aero-magnetic measurement over the summit area, taking visual and infra-red images from low altitude, and volcanic gas sampling. We present preliminary results of the near summit observations using unmanned helicopter. The light-weight (5kg) and solar-powered seismic stations were designed exclusively for helicopter installation. They transmit seismic data every 10 minutes by using mobile data communication network. We could install them within 500m from the summit crater on 17, April. On 29 May, Shin-dake crater erupted again and the newly installed seismic stations were all destroyed by this eruption. The seismic stations could transmit data until just before the eruption. These data made us possible to evaluate the change in seismic activity leading up to the eruption. An aero-magnetic survey was conducted on 17 and 18 April. The flight altitude was between 100m and 150m above the ground (i.e a draped magnetic survey) . Path interval is 100m and the total flight path length is 80km. The magnetic intensity data were converted to magnetization of the edifice of Shin-dake. Comparison between the result this time with that obtained in 2001 shows demagnetization near the summit area. Temperature measurement over the summit area detected 368ºC　at the fissure on the western flank. Chemical composition of the volcanic gas was measured. Maximum concentration of SO2 was 28ppm and the apparent equilibrium temperature estimated from the gas composition was 550 ºC. CO2/SO2 ratio did not change significantly but a large variation in SO2/H2S ratio was observed.

Mechanisms and actuators for rotorcraft blade morphing

NASA Astrophysics Data System (ADS)

Vocke, Robert D., III

The idea of improved fight performance through changes in the control surfaces dates back to the advent of aviation with the Wright brothers' pioneering work on "wing warping," but it was not until the recent progress in material and actuator development that such control surfaces seemed practical for modern aircraft. This has opened the door to a new class of aircraft that have the ability to change shape or morph, which are being investigated due to the potential to have a single platform serve multiple mission objectives, as well as improve performance characteristics. While the majority of existing research for morphing aircraft has focused on fixedwing aircraft, rotary-wing aircraft have begun to receive more attention. The purpose of this body of work is to investigate the current state of morphing actuation technology for rotorcraft and improve upon it. Specifically, this work looks at two types of morphing: Pneumatic Artificial Muscle (PAM) actuated trailing edge flaps and conformal variable diameter morphing. First, active camber changes through the use of PAM powered trailing edge flaps were investigated due to the potential for reductions in power requirements and vibration/noise levels. A PAM based antagonistic actuation system was developed utilizing a novel combination of mechanism geometry and PAM bias contraction optimization to overcome the natural extension stiffening characteristics of PAMs. In open-loop bench-top testing against a "worst-case" constant torsional loading, the system demonstrated actuation authority suitable for both primary control and vibration/noise reduction. Additionally, closed-loop test data indicated that the system was capable of tracking complex waveforms consistent with those needed for rotorcraft control. This system demonstrated performance on-par with the state of the art pneumatic trailing edge flap actuators, yet with a much smaller footprint and impact on the rotor-blade. The second morphing system developed in this work is a conformal variable diameter rotor system suitable for implementation on a modern tilt-rotor aircraft, which can reduce power requirements in both cruise and hover configurations. An initial prototype variable span airfoil was constructed using a silicone elastomer matrix composite skin and a plastic rapid prototyped morphing substructure. Benchtop and wind tunnel tests verified the ability of this system to increase active wing area by 100%. The prototype technology was then matured for use in the harsh rotor blade environment, with a much stiffer polyurethane skin and a titanium substructure. Coupon testing verified the efficacy of this approach, and a final conceptual design was completed using the stiffness-tuning characteristics of the morphing substructure to create a self-actuating morphing blade tip.

Comparison of Two Fluid Replacement Protocols During a 20-km Trail Running Race in the Heat.

PubMed

Lopez, Rebecca M; Casa, Douglas J; Jensen, Katherine A; Stearns, Rebecca L; DeMartini, Julie K; Pagnotta, Kelly D; Roti, Melissa W; Armstrong, Lawrence E; Maresh, Carl M

2016-09-01

Lopez, RM, Casa, DJ, Jensen, K, Stearns, RL, DeMartini, JK, Pagnotta, KD, Roti, MW, Armstrong, LE, and Maresh, CM. Comparison of two fluid replacement protocols during a 20-km trail running race in the heat. J Strength Cond Res 30(9): 2609-2616, 2016-Proper hydration is imperative for athletes striving for peak performance and safety, however, the effectiveness of various fluid replacement strategies in the field setting is unknown. The purpose of this study was to investigate how two hydration protocols affect physiological responses and performance during a 20-km trail running race. A randomized, counter-balanced, crossover design was used in a field setting (mean ± SD: WBGT 28.3 ± 1.9° C). Well-trained male (n = 8) and female (n = 5) runners (39 ± 14 years; 175 ± 9 cm; 67.5 ± 11.1 kg; 13.4 ± 4.6% BF) completed two 20-km trail races (5 × 4-km loop) with different water hydration protocols: (a) ad libitum (AL) consumption and (b) individualized rehydration (IR). Data were analyzed using repeated measures ANOVA. Paired t-tests compared pre-race-post-race measures. Main outcome variables were race time, heart rate (HR), gastrointestinal temperature (TGI), fluid consumed, percent body mass loss (BML), and urine osmolality (Uosm). Race times between groups were similar. There was a significant condition × time interaction (p = 0.048) for HR, but TGI was similar between conditions. Subjects replaced 30 ± 14% of their water losses in AL and 64 ± 16% of their losses in IR (p < 0.001). Ad libitum trial experienced greater BML (-2.6 ± 0.5%) compared with IR (-1.3 ± 0.5%; p < 0.001). Pre-race to post-race Uosm differences existed between AL (-273 ± 146 mOsm) and IR (-145 ± 215 mOsm, p = 0.032). In IR, runners drank twice as much fluid than AL during the 20-km race, leading to > 2% BML in AL. Ad libitum drinking resulted in 1.3% greater BML over the 20-km race, which resulted in no thermoregulatory or performance differences from IR.

27 CFR 9.124 - Wild Horse Valley.

Code of Federal Regulations, 2014 CFR

2014-04-01

... direction approximately .9 mile to the summit of an unnamed hill having a marked elevation of 1,804 feet; (3... 1,824 feet; (4) Then south-southeasterly approximately .6 mile to the summit of an unnamed hill having a marked elevation of 1,866 feet; (5) Then south-southeasterly approximately .5 mile to the summit...

27 CFR 9.124 - Wild Horse Valley.

Code of Federal Regulations, 2013 CFR

2013-04-01

... direction approximately .9 mile to the summit of an unnamed hill having a marked elevation of 1,804 feet; (3... 1,824 feet; (4) Then south-southeasterly approximately .6 mile to the summit of an unnamed hill having a marked elevation of 1,866 feet; (5) Then south-southeasterly approximately .5 mile to the summit...

27 CFR 9.124 - Wild Horse Valley.

Code of Federal Regulations, 2012 CFR

2012-04-01

... direction approximately .9 mile to the summit of an unnamed hill having a marked elevation of 1,804 feet; (3... 1,824 feet; (4) Then south-southeasterly approximately .6 mile to the summit of an unnamed hill having a marked elevation of 1,866 feet; (5) Then south-southeasterly approximately .5 mile to the summit...

Wild Food Summit: Anishinaabe Relearning Traditional Gathering Practices

ERIC Educational Resources Information Center

Sorensen, Barbara Ellen

2011-01-01

Wild Food Summits is a program initiated by Steve Dahlberg, the White Earth Tribal & Community College Extension director. Dahlberg began Wild Food Summits to teach people about identifying and gathering wild greens, mushrooms, and other edible plant life. The whole community comes together to cook and eat the foods. The tribal college has…

ACHP | Heritage Tourism and the Federal Government: Summit II Proceedings

Science.gov Websites

Search skip specific nav links Home arrow Publications arrow Intro: Heritage Tourism and the Federal Government: Summit II—Report of Proceedings Heritage Tourism and the Federal Government: Summit II—Report Heritage tourism promotes the preservation of communities' historic resources, educates tourists and local

Announcing Supercomputer Summit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wells, Jack; Bland, Buddy; Nichols, Jeff

Summit is the next leap in leadership-class computing systems for open science. With Summit we will be able to address, with greater complexity and higher fidelity, questions concerning who we are, our place on earth, and in our universe. Summit will deliver more than five times the computational performance of Titan’s 18,688 nodes, using only approximately 3,400 nodes when it arrives in 2017. Like Titan, Summit will have a hybrid architecture, and each node will contain multiple IBM POWER9 CPUs and NVIDIA Volta GPUs all connected together with NVIDIA’s high-speed NVLink. Each node will have over half a terabyte ofmore » coherent memory (high bandwidth memory + DDR4) addressable by all CPUs and GPUs plus 800GB of non-volatile RAM that can be used as a burst buffer or as extended memory. To provide a high rate of I/O throughput, the nodes will be connected in a non-blocking fat-tree using a dual-rail Mellanox EDR InfiniBand interconnect. Upon completion, Summit will allow researchers in all fields of science unprecedented access to solving some of the world’s most pressing challenges.« less

The 2015 Chile-U.S. Astronomy Education Outreach Summit in Chile

NASA Astrophysics Data System (ADS)

Preston, Sandra Lee; Arnett, Dinah; Hardy, Eduardo; Cabezón, Sergio; Spuck, Tim; Fields, Mary Sue; Smith, R. Chris

2015-08-01

The first Chile-U.S. Astronomy Education Outreach Summit occurred March 22-28, 2015. The Summit was organized and supported by the U.S. Embassy in Chile, Associated Universities Inc., Association of Universities for Research in Astronomy, the Carnegie Institution for Science, the Image of Chile Foundation, the National Science Foundation, and La Comisión Nacional de Investigación Científica y Tecnológica. The Summit brought together a team of leading experts and officials from Chile and the U.S. to share best practices in astronomy education and outreach. In addition, Summit participants discussed enhancing existing partnerships, and building new collaborations between U.S. Observatories and astronomy education outreach leaders in Chile.The Summit was an exciting and intense week of work and travel. Discussions opened in Santiago on March 22 with a variety of astronomy education and public outreach work sessions, a public forum, and on March 23 the U.S. Embassy sponsored a Star Party. On Tuesday, March 24, the Summit moved to San Pedro de Atacama, where activities included work sessions, a visit to the Atacama Large Millimeter/Submillimeter Array telescope facilities, and a second public forum. From San Pedro, the team traveled to La Serena for additional work sessions, visits to Gemini and Cerro Tololo, a third public forum, and the closing session. At each stop, authorities and the broader community were invited to participate and provide valuable input on the current state, and the future, of astronomy education and public outreach.Following the Summit a core working committee has continued meeting to draft a “roadmap document” based on findings from the Summit. This document will help to identify potential gaps in astronomy outreach efforts, and how the U.S. facilities and Chilean institutions might work together strategically to address these needs. The first draft of this “roadmap document” will be made available for comment in both Spanish and English in late September 2015.

Campaign gravity results From kilauea volcano, hawaii, 2009-2011

NASA Astrophysics Data System (ADS)

Wilkinson, S. K.; Poland, M. P.; Battaglia, M.

2011-12-01

The gravity and leveling networks at Kilauea's summit caldera consist of approximately 60 benchmarks that are measured with a gravimeter as well as leveled for elevation data. Gravity data were collected in December 2009, June 2010 and March 2011. Elevation data were collected in 2009 and 2010. For the gravity survey completed in March 2011, we use InSAR and GPS data to assess elevation changes at the time of the gravity survey. During December 2009-March 2011, Kilauea's summit was characterized by minor deflation, following trends established in mid-2007. In mid-2010, however, the summit began to inflate, with a rate that increased significantly in October 2010. This inflation was associated with a decrease in the effusion rate from the volcano's east rift zone eruptive vents, suggesting that Kilauea's magma plumbing system was backing up. On March 5, 2011, a 2-km-long fissure eruption began about 3 km west of Pu`u `O`o, causing rapid summit deflation as magma drained from beneath the summit to feed the new eruptive vents. The fissure eruption ended on March 9, at which time the summit began to reinflate. Preliminary analysis of gravity data collected before and after the fissure eruption indicates a complex pattern of mass flow beneath the summit caldera. Net summit deformation was negligible between December 2009 and June 2010, but there is a residual gravity high centered near Halema'uma'u Crater. For the December 2009 to March 2011 time period, the caldera shows net subsidence. A positive residual gravity anomaly is located southeast of Halema'uma'u Crater while a negative residual gravity anomaly exists north of Halema'uma'u Crater. These patterns are somewhat unexpected, given the sudden draining of magma from beneath the summit during the March 5-9 fissure eruption. We conclude that the campaign gravity data were not collected at the optimal times to "catch" this event. Nevertheless, the data can still be used to assess different aspects of Kilauea's magma system.

Antarctic Treaty Summit to Focus on Global Science Policy Lessons

NASA Astrophysics Data System (ADS)

Berkman, Paul Arthur; Walton, David W. H.; Weiler, C. Susan

2008-10-01

The Antarctic Treaty Summit, which will coincide with the fiftieth anniversary of the treaty's signing, will be held at the Smithsonian Institution's National Museum of Natural History, in Washington, D. C., from 30 November to 3 December 2009. The summit will provide an open international forum for scientists, legislators, lawyers, administrators, educators, students, corporate executives, historians, and other members of global civil society to explore science policy achievements from the first 50 years of the Antarctic Treaty. In addition, the summit will complement official government celebrations of the Antarctic Treaty anniversary that do not include public participation.

Winter Camp: A Blog from the Greenland Summit, Part II

NASA Technical Reports Server (NTRS)

Koenig, Lora

2009-01-01

An earlier issue presents the first half of the author's experience living and working at the National Science Foundation's (NSF) Greenland Summit Camp. The author is a remote-sensing glaciologist at NASA s Goddard Space Flight Center. She took measurements that will be used to validate data collected by NASA s Aqua, Terra, and Ice, Clouds, and land Elevation Satellite (ICESat) satellites with ground-truth measurements of the Greenland Ice Sheet she made at Summit Camp from November 2008-February 2009. This article presents excerpts from the second half of her stay and work at the Greenland Summit.

Catalog of Tephra Samples from Kilauea's Summit Eruption, March-December 2008

USGS Publications Warehouse

Wooten, Kelly M.; Thornber, Carl R.; Orr, Tim R.; Ellis, Jennifer F.; Trusdell, Frank A.

2009-01-01

The opening of a new vent within Halema'uma'u Crater in March 2008 ended a 26-year period of no eruptive activity at the summit of Kilauea Volcano. It also heralded the first explosive activity at Kilauea's summit since 1924 and the first of eight discrete explosive events in 2008. At the onset of the eruption, the Hawaiian Volcano Observatory (HVO) initiated a rigorous program of sample collection to provide a temporally constrained suite of tephra samples for petrographic, geochemical, and isotopic studies. Petrologic studies help us understand conditions of magma generation at depth; processes related to transport, storage, and mixing of magma within the shallow summit region; and specific circumstances leading to explosive eruptions. This report provides a catalog of tephra samples erupted at Kilauea's summit from March 19, 2008, through the end of 2008. The Kilauea 2008 Summit Sample Catalog is tabulated in the accompanying Microsoft Excel file, of2009-1134.xls (four file types linked on right). The worksheet in this file provides sampling information and sample descriptions. Contextual information for this catalog is provided below and includes (1) a narrative of 2008 summit eruptive activity, (2) a description of sample collection methods, (3) a scheme for characterizing a diverse range in tephra lithology, and (4) an explanation of each category of sample information (column headers) in the Microsoft Excel worksheet.

A Clean Energy Roadmap: Forging the Path Ahead

ERIC Educational Resources Information Center

Ewing Marion Kauffman Foundation, 2010

2010-01-01

In 2010, the Ewing Marion Kauffman Foundation co-convened three cross-sector summits to develop recommendations for growing energy innovation in the United States. The first summit was held in Washington, D.C., on May 7, 2010, in partnership with the White House. Gallup and the city of Omaha, Nebraska, hosted the second summit on June 16, 2010,…

Howard's End: A Narrative Memoir of Political Contrivance, Neoconservative Ideology and the Australian History Curriculum

ERIC Educational Resources Information Center

Taylor, Tony

2009-01-01

In August 2006, Australia's conservative prime minister John Howard convened a history summit in Canberra. The purported goal of the summit was the framing of a nationally-acceptable curriculum in Australian history. However, as this article suggests, Howard's hidden intention was to use the summit as a device for introducing a narrowly…

27 CFR 9.49 - Central Delaware Valley.

Code of Federal Regulations, 2014 CFR

2014-04-01

... starting point of the following boundary description is the summit of Strawberry Hill, which is located in.... (2) Boundary Description: (i) From the summit of Strawberry Hill (475 feet) in a straight line to the... summit of Strawberry Hill (475 feet). [T.D. ATF-168, 49 FR 10117, Mar. 19, 1984, as amended by T.D. ATF...

27 CFR 9.49 - Central Delaware Valley.

Code of Federal Regulations, 2013 CFR

2013-04-01

... starting point of the following boundary description is the summit of Strawberry Hill, which is located in.... (2) Boundary Description: (i) From the summit of Strawberry Hill (475 feet) in a straight line to the... summit of Strawberry Hill (475 feet). [T.D. ATF-168, 49 FR 10117, Mar. 19, 1984, as amended by T.D. ATF...

27 CFR 9.49 - Central Delaware Valley.

Code of Federal Regulations, 2012 CFR

2012-04-01

... starting point of the following boundary description is the summit of Strawberry Hill, which is located in.... (2) Boundary Description: (i) From the summit of Strawberry Hill (475 feet) in a straight line to the... summit of Strawberry Hill (475 feet). [T.D. ATF-168, 49 FR 10117, Mar. 19, 1984, as amended by T.D. ATF...

27 CFR 9.49 - Central Delaware Valley.

Code of Federal Regulations, 2011 CFR

2011-04-01

... starting point of the following boundary description is the summit of Strawberry Hill, which is located in.... (2) Boundary Description: (i) From the summit of Strawberry Hill (475 feet) in a straight line to the... summit of Strawberry Hill (475 feet). [T.D. ATF-168, 49 FR 10117, Mar. 19, 1984, as amended by T.D. ATF...

We the Children: Meeting the Promises of the World Summit for Children.

ERIC Educational Resources Information Center

Annan, Kofi A.

This abridged version of the Secretary-General's report to the United Nations General Assembly's Special Session on Children details the achievements of the 1990 World Summit for Children. Nearly 150 countries provided national progress reports of their implementation of goals set forth in the Summit and the 1989 Convention on the Rights of the…

A Bold New Math Class

ERIC Educational Resources Information Center

Khan, Salman; Slavitt, Elizabeth

2013-01-01

Summit San Jose is part of the Summit Public Schools network, a group of charter schools in California's Bay Area. In 2011, when Summit San Jose first opened its new high school with a cohort of 9th graders, the teachers decided to pilot Khan Academy. At the time, they had piloted their math resources and platform with five classrooms in Los…

2016 Personalized Learning & Student Success Summit: Summary from the NMC

ERIC Educational Resources Information Center

New Media Consortium, 2016

2016-01-01

The New Media Consortium (NMC) hosted the Personalized Learning & Student Success Summit at SXSWedu on March 7-9 in Austin, Texas. The summit convened grantees and partners of the Postsecondary Strategy at the Bill & Melinda Gates Foundation and served as a call-to-action for education leaders to first imagine if and then commit to trying…

Community Colleges in the Evolving STEM Education Landscape: Summary of a Summit

ERIC Educational Resources Information Center

Olson, Steve; Labov, Jay B.

2012-01-01

The National Research Council (NRC) and National Academy of Engineering (NAE) have released a new report, "Community Colleges in the Evolving STEM Education Landscape: Summary of a Summit." Based on a national summit that was supported by the National Science Foundation and organized by the NRC and the NAE, the report highlights the importance of…

ORA User’s Guide 2008

DTIC Science & Technology

2008-07-01

12 10 Stargate - Summit - Synopsis...Applications 13 10 Stargate - Summit - Synopsis 10.1 Story Background The data for this scenario is based on the Sci-Fi tv show, Stargate SG-1 and...all of the head Gou’ald in one fell swoop by inflitrating a summit and poisoning them all simultanously. With the help of Stargate Command and the

It's Not a Matter of Time: Highlights from the 2011 Competency-Based Summit

ERIC Educational Resources Information Center

Sturgis, Chris; Patrick, Susan; Pittenger, Linda

2011-01-01

From Anchorage, Alaska, to Orlando, Florida, and from Gray, Maine, to Yuma, Arizona, one hundred competency-based innovators gathered at the Competency-Based Learning Summit in March 2011. Sponsored by the Council of Chief State School Officers (CCSSO) and the International Association for K-12 Online Learning (iNACOL), the Summit was developed in…

Communicating the Emerging Roles of Librarians to Teachers through a Collaborative K-12 and Higher Education Partnership

ERIC Educational Resources Information Center

Schroeder, Eileen E.; Fisher, Stacy

2015-01-01

In 2010 the Wisconsin Department of Public Instruction (DPI) responded to rapid changes in school libraries by convening the "Wisconsin School Library Summit: Envisioning 21st Century Learners and School Library Media Programs." Summit participants discussed the future of school libraries in Wisconsin. During the summit, several…

27 CFR 9.49 - Central Delaware Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

... starting point of the following boundary description is the summit of Strawberry Hill, which is located in.... (2) Boundary Description: (i) From the summit of Strawberry Hill (475 feet) in a straight line to the... summit of Strawberry Hill (475 feet). [T.D. ATF-168, 49 FR 10117, Mar. 19, 1984, as amended by T.D. ATF...

The State of the World's Children, 1991.

ERIC Educational Resources Information Center

Grant, James P.

The World Summit for children was held at the United Nations, New York, on September 30, 1990. The summit set child health goals to be achieved by the year 2000, and offered strategies and guiding principles for achieving the goals. The summit proposed a new ethic for children which called for children's needs to be given high priority in the…

Test Equity for Individuals Who Are Deaf or Hard of Hearing. PEPNet Test Equity Summit

ERIC Educational Resources Information Center

PEPNet-West, 2010

2010-01-01

This paper presents the highlights of the 2008 Test Equity Summit held in Bloomfield, Colorado last August 6-8, 2008. The 2008 Test Equity Summit convened by the Postsecondary Education Programs Network (PEPNet) identified and examined problems, challenges, and issues that academic and psychoeducational tests pose for individuals who are deaf or…

Restoring the Trust in Native Education. Annual NIEA Legislative Summit (14th, February 7-9, 2011). Briefing Papers

ERIC Educational Resources Information Center

National Indian Education Association, 2011

2011-01-01

Several briefing papers were presented during the 14th Annual National Indian Education Association (NIEA) Legislative Summit. This briefing book contains the following papers presented during the summit: (1) Restoring the Trust in Native Education; (2) NIEA Legislative Priorities for 2011: "Talking Points"; (3) Reauthorization of the…

High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer.

PubMed

De Miguel, Diego; Gallego-Lleyda, Ana; Ayuso, José María; Pejenaute-Ochoa, Dolores; Jarauta, Vidal; Marzo, Isabel; Fernández, Luis J; Ochoa, Ignacio; Conde, Blanca; Anel, Alberto; Martinez-Lostao, Luis

2016-12-28

During the last years, a great effort has been invested into developing new TRAIL formulations with increased bioactivity, trying to overcome the resistance to conventional soluble TRAIL (sTRAIL) exhibited by many primary tumours. In our group, we have generated artificial lipid nanoparticles decorated with sTRAIL (LUV-TRAIL), emulating the physiological TRAIL-containing exosomes by which T-cells release TRAIL upon activation. We already demonstrated that LUV-TRAIL has greater cytotoxicity against both chemoresistant haematologic tumour cells and epithelial carcinoma cells compared to a form of sTRAIL similar to that used in clinical trials. In this study we have tested LUV-TRAIL in several human colon cancer cell lines with different sensitivity to sTRAIL. LUV-TRAIL significantly improved sTRAIL cytotoxicity in all colon cancer cell lines tested. Trying to ascertain the molecular mechanism by which LUV-TRAIL exhibited improved cytotoxicity, we demonstrated that TRAIL-coated lipid nanoparticles were able to activate DR5 more efficiently than sTRAIL, and this relied on LUV-TRAIL ability to promote DR5 clustering on the cell surface. Moreover, we show that TRAIL molecules are arranged in higher order oligomers only in LUV-TRAIL, which may explain their enhanced DR5 clustering ability. Finally, LUV-TRAIL showed significantly better antitumour activity than sTRAIL in an in vivo model using HCT-116 xenograft tumours in nude mice, validating its potential clinical application. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Mt. Whitney: determinants of summit success and acute mountain sickness.

PubMed

Wagner, Dale R; D'Zatko, Kim; Tatsugawa, Kevin; Murray, Ken; Parker, Daryl; Streeper, Tim; Willard, Kevin

2008-10-01

The aim of this study was to determine the prevalence of summit success and acute mountain sickness (AMS) on Mt. Whitney (4419 m) and to identify variables that contribute to both. Hikers (N = 886) attempting the summit were interviewed at the trailhead upon their descent. Questionnaires included demographic and descriptive data, acclimatization and altitude history, and information specific to the ascent. The Lake Louise Self-Assessment Score was used to make a determination about the occurrence of AMS. Logistic regression techniques were used to calculate odds ratios (OR) for AMS and summit success. Forty-three percent of the sample met the criteria for AMS, and 81% reached the summit. The odds of experiencing AMS were reduced with increases in age (adjusted 10-yr OR = 0.78; P < 0.001), number of hours spent above 3000 m in the 2 wk preceding the ascent (adjusted 24-h OR = 0.71; P < 0.001), and for females (OR = 0.68; P = 0.02). Climbers who had a history of AMS (OR = 1.41; P = 0.02) and those taking analgesics (OR = 2.39; P < 0.001) were more likely to experience AMS. As climber age increased, the odds of reaching the summit decreased (adjusted 10-yr OR = 0.75; P < 0.001). However, increases in the number of hours per week spent training (adjusted 5-h OR = 1.24; P = 0.05), rate of ascent (adjusted 50 m x h(-1) OR = 1.13; P = 0.04), and previous high-altitude record (adjusted 500 m OR = 1.26; P < 0.001) were all associated with increased odds for summit success. A high percentage of trekkers reached the summit despite having symptoms of AMS.

Implications for eruptive processes as indicated by sulfur dioxide emissions from Kilauea Volcano, Hawai'i, 1979-1997

USGS Publications Warehouse

Sutton, A.J.; Elias, T.; Gerlach, T.M.; Stokes, J.B.

2001-01-01

Kı̄lauea Volcano, Hawai‘i, currently hosts the longest running SO2 emission-rate data set on the planet, starting with initial surveys done in 1975 by Stoiber and his colleagues. The 17.5-year record of summit emissions, starting in 1979, shows the effects of summit and east rift eruptive processes, which define seven distinctly different periods of SO2 release. Summit emissions jumped nearly 40% with the onset (3 January 1983) of the Pu`u `Ō`ō-Kūpaianaha eruption on the east rift zone (ERZ). Summit SO2 emissions from Kı̄lauea showed a strong positive correlation with short-period, shallow, caldera events, rather than with long-period seismicity as in more silicious systems. This correlation suggests a maturation process in the summit magma-transport system from 1986 through 1993. During a steady-state throughput-equilibrium interval of the summit magma reservoir, integration of summit-caldera and ERZ SO2 emissions reveals an undegassed volume rate of effusion of 2.1×105 m3/d. This value corroborates the volume-rate determined by geophysical methods, demonstrating that, for Kı̄lauea, SO2 emission rates can be used to monitor effusion rate, supporting and supplementing other, more established geophysical methods. For the 17.5 years of continuous emission rate records at Kı̄lauea, the volcano has released 9.7×106 t (metric tonnes) of SO2, 1.7×106 t from the summit and 8.0×106 t from the east rift zone. On an annual basis, the average SO2 release from Kı̄lauea is 4.6×105 t/y, compared to the global annual volcanic emission rate of 1.2×107 t/y.

Spatiotemporal model of Kīlauea's summit magmatic system inferred from InSAR time series and geometry-free time-dependent source inversion

NASA Astrophysics Data System (ADS)

Zhai, Guang; Shirzaei, Manoochehr

2016-07-01

Kīlauea volcano, Hawai`i Island, has a complex magmatic system including summit reservoirs and rift zones. Kinematic models of the summit reservoir have so far been limited to first-order analytical solutions with predetermined geometry. To explore the complex geometry and kinematics of the summit reservoir, we apply a multitrack wavelet-based InSAR (interferometric synthetic aperture radar) algorithm and a novel geometry-free time-dependent modeling scheme. To map spatiotemporally distributed surface deformation signals over Kīlauea's summit, we process synthetic aperture radar data sets from two overlapping tracks of the Envisat satellite, including 100 images during the period 2003-2010. Following validation against Global Positioning System data, we invert the surface deformation time series to constrain the spatiotemporal evolution of the magmatic system without any prior knowledge of the source geometry. The optimum model is characterized by a spheroidal and a tube-like zone of volume change beneath the summit and the southwest rift zone at 2-3 km depth, respectively. To reduce the model dimension, we apply a principal component analysis scheme, which allows for the identification of independent reservoirs. The first three PCs, explaining 99% (63.8%, 28.5%, and 6.6%, respectively) of the model, include six independent reservoirs with a complex interaction suggested by temporal analysis. The data and model presented here, in agreement with earlier studies, improve the understanding of Kīlauea's plumbing system through enhancing the knowledge of temporally variable magma supply, storage, and transport beneath the summit, and verify the link between summit magmatic activity, seismicity, and rift intrusions.

Internet-Delivered Disease Management for Recurrent Depression: A Multicenter Randomized Controlled Trial.

PubMed

Kordy, Hans; Wolf, Markus; Aulich, Kai; Bürgy, Martin; Hegerl, Ulrich; Hüsing, Johannes; Puschner, Bernd; Rummel-Kluge, Christine; Vedder, Helmut; Backenstrass, Matthias

2016-01-01

Strategies to improve the life of patients suffering from recurrent major depression have a high relevance. This study examined the efficacy of 2 Internet-delivered augmentation strategies that aim to prolong symptom-free intervals. Efficacy was tested in a 3-arm, multicenter, open-label, evaluator-blind, randomized controlled trial. Upon discharge from inpatient mental health care, 232 adults with 3 or more major depressive episodes were randomized to 1 of 2 intervention groups (SUMMIT or SUMMIT-PERSON) or to treatment as usual (TAU) alone. Over 12 months, participants in both intervention arms received, in addition to TAU, intense monitoring via e-mail or a smartphone, including signaling of upcoming crises, assistance with personal crisis management, and facilitation of early intervention. SUMMIT-PERSON additionally offered regular expert chats. The primary outcome was 'well weeks', i.e. weeks with at most mild symptoms assessed by the Longitudinal Interval Follow-Up Evaluation, during 24 months after the index treatment. SUMMIT compared to TAU reduced the time with an unwell status (OR 0.48; 95% CI 0.23-0.98) through faster transitions from unwell to well (OR 1.44; 95% CI 0.83-2.50) and slower transitions from well to unwell (OR 0.69; 95% CI 0.44-1.09). Contrary to the hypothesis, SUMMIT-PERSON was not superior to either SUMMIT (OR 0.77; 95% CI 0.38-1.56) or TAU (OR 0.62; 95% CI 0.31-1.24). The efficacy of SUMMIT was strongest 8 months after the intervention. The fully automated Internet-delivered augmentation strategy SUMMIT has the potential to improve TAU by reducing the lifelong burden of patients with recurrent depression. The fact that the effects wear off suggests a time-unlimited extension. © 2016 S. Karger AG, Basel.

Self-sustained oscillations of a shock wave interacting with a boundary layer on a supercritical airfoil

NASA Technical Reports Server (NTRS)

Ventres, C. S.; Howe, M. S.

1984-01-01

A theory is proposed of the self-sustaining oscillations of a weak shock on an airfoi in steady, transonic flow. The interaction of the shock with the boundary layer on the airfoil produces displacement thickness fluctuations which convect downstream and generate sound by interaction with the trailing edge. A feedback loop is established when this sound impinges on the shock wave, resulting in the production of further fluctuations in the displacement thickness. The details are worked out for an idealized mean boundary layer velocity profile, but strong support for the basic hypotheses of the theory is provided by a comparison with recent experiments involving the generation of acoustic 'tone bursts' by a supercritical airfoil section.

Self-sustained oscillations of a shock wave interacting with a boundary layer on a supercritical airfoil

NASA Technical Reports Server (NTRS)

Ventres, C. S.; Howe, M. S.

1983-01-01

A theory is proposed of the self-sustaining oscillations of a weak shock on an airfoil in steady, transonic flow. The interaction of the shock with the boundary layer on the airfoil produces displacement thickness fluctuations which convect downstream and generate sound by interaction with the trailing edge. A feedback loop is established when this sound impinges on the shock wave, resulting in the production of further fluctuations in the displacement thickness. The details are worked out for an idealized mean boundary layer velocity profile, but strong support for the basic hypotheses of the theory is provided by a comparison with recent experiments involving the generation of acoustic "tone bursts' by a supercritical airfoil section.

Thermal areas on Kilauea and Mauna Loa Volcanoes, Hawaii

USGS Publications Warehouse

Casadevall, Thomas J.; Hazlett, Richard W.

1983-01-01

Active thermal areas are concentrated in three areas on Mauna Loa and three areas on Kilauea. High-temperature fumaroles (115-362°C) on Mauna Loa are restricted to the summit caldera, whereas high-temperature fumaroles on Kilauea are found in the upper East Rift Zone (Mauna Ulu summit fumaroles, 562°C), middle East Rift Zone (1977 eruptive fissure fumaroles), and in the summit caldera. Solfataric activity that has continued for several decades occurs along border faults of Kilauea caldera and at Sulphur Cone on the southwest rift zone of Mauna Loa. Solfataras that are only a few years old occur along recently active eruptive fissures in the summit caldera and along the rift zones of Kilauea. Steam vents and hot-air cracks also occur at the edges of cooling lava ponds, on the summits of lava shields, along faults and graben fractures, and in diffuse patches that may reflect shallow magmatic intrusions.

Magma degassing triggered by static decompression at Kīlauea Volcano, Hawai‘i

USGS Publications Warehouse

Poland, Michael P.; Jeff, Sutton A.; Gerlach, Terrence M.

2009-01-01

During mid-June 2007, the summit of Kīlauea Volcano, Hawai‘i, deflated rapidly as magma drained from the subsurface to feed an east rift zone intrusion and eruption. Coincident with the deflation, summit SO2 emission rates rose by a factor of four before decaying to background levels over several weeks. We propose that SO2 release was triggered by static decompression caused by magma withdrawal from Kīlauea's shallow summit reservoir. Models of the deflation suggest a pressure drop of 0.5–3 MPa, which is sufficient to trigger exsolution of the observed excess SO2 from a relatively small volume of magma at the modeled source depth beneath Kīlauea's summit. Static decompression may also explain other episodes of deflation accompanied by heightened gas emission, including the precursory phases of Kīlauea's 2008 summit eruption. Hazards associated with unexpected volcanic gas emission argue for increased awareness of magma reservoir pressure fluctuations.

Mechanism of trail following by the arboreal termite Nasutitermes corniger (Isoptera: Termitidae).

PubMed

Gazai, Vinícius; Bailez, Omar; Viana-Bailez, Ana Maria

2014-01-01

In this study, we investigated the mechanisms used by the arboreal termite Nasutitermes corniger (Motschulsky, 1855) to follow trails from the nest to sources of food. A plate containing one of seven trail types was used to connect an artificial nest of N. corniger with an artificial foraging arena. The trail types were: termite trail; paraffined termite trail; trail made of paraffin; rectal fluid extract trail; sternal gland extract trail; feces extract trail; and solvent trail (control). In each test, the time was recorded from the start of the test until the occurrence of trail following, at which point the number of termites that followed the trail for least 5 cm in the first 3 min of observation was recorded. The delay for termites initiating trail following along the termite trail was lower (0.55 ± 0.16 min) than in the trails of sternal gland extract (1.05 ± 0.08 min) and trails of termite feces extract (1.57 ± 0.21 min) (F(2), (48) = 22.59, P < 0.001). The number of termites that followed the termite trail was greater (207.3 ± 17.3) than the number that followed the trail of termite feces extract (102.5 ± 9.4) or sternal gland extract (36, 9 ± 1.6) (F(2), (48) = 174.34, P < 0.001). Therefore, feces on the trail may play an important role alongside sternal gland pheromones in increasing the persistence of the trail.

Accordant summit heights, summit levels and the origin of the ``upper denudation level'' in the Serra do Mar (SE-Brazil, São Paulo): A study of hillslope forms and processes

NASA Astrophysics Data System (ADS)

Römer, Wolfgang

2008-08-01

In southern São Paulo the Serra do Mar is characterized by three distinct terrain types: 1) highly dissected areas with closely spaced ridges and accordant summit heights; 2) multiconvex hills; and 3) terrains with highly elevated watershed areas, irregular summit heights, and locally subdued relief. The development of this landscape is considered to be the result of the Cenozoic block-faulting and of the influences that are exerted by the differing lithological and structural setting of block-faulted compartments on weathering and erosion processes. In areas characterized by pronounced accordant summits the close coincidence between hillslope angle and the angle of limiting stability against landsliding points to a close adjustment of hillslope gradients and the mechanical properties of the regolith. The relative height of the hillslopes is functionally related to the spacing of the valleys and the gradient of the hillslopes. In areas with a regular spacing of v-shaped valleys and uniform rocks, this leads to the intersection of valley-side slopes in summits and ridges at a certain elevation. This elevation is determined by the length and steepness of the valley-side slopes. Therefore, the heights of the summits are geometrically constrained and are likely to indicate the upper limit of summit heights or an "upper denudation level" that is adjusted by hillslope processes to the incising streams. Accordant summit heights of this type are poor indicators of formerly more extensive denudation surfaces as it is also likely that they are a result of the long-term adjustment of hillslopes to river incision. The steep mountain flanks of block-faulted compartments on the other hand, comprise regolith-covered hillslopes that are closely adjusted to the maximum stable gradient as well as rock-slopes that are controlled by the rock-mass strength. Their summits are usually not accommodated into uniform summit levels. Highly elevated watershed areas exhibiting a subdued relief are detached from the base level response. On granitoid rocks these areas are often characterized by the rocky hills and domal rock outcrops. However, differences in the elevation of interfluves and summits between rocks of differing resistance and in the elevation of lithologically distinct individual fault-blocks imply that long-term weathering and erosion has transformed and lowered these landscapes. Therefore, these areas cannot be interpreted as a remnant of a pre-uplift topography and it appears to be unlikely that the height of the summits correlates with formerly more widespread planation surfaces in the far hinterland. The studies indicate that concepts such as the parallel retreat of hillslopes cannot account for the observed differences in the landscape. It is suggested that the Serra do Mar is consumed from the Atlantic and the inland side by spatially non-uniform developmental states. These states are determined by local differences in the coupling and distance to the regional base level and sea-level or are due to lithological and structural controls between and within the block-faulted compartments.

How Well Has NCLB Worked? How Do We Get the Revisions We Want?

ERIC Educational Resources Information Center

Lewis, Anne C.

2007-01-01

In this article, the author presents a description of Phi Delta Kappa International's 2006 Summit on Public Education. The 2006 Summit opened with a stimulating panel discussion on the hottest topic in education--the No Child Left Behind Act. The Summit's emphasis on NCLB had a clear purpose--to stimulate their members to become involved in the…

Supporting and Staffing High-Needs Schools: Recommendations from South Carolina's National Board Certified Teachers[R

ERIC Educational Resources Information Center

Berry, Barnett; Rasberry, Melissa; Byrd, Ann

2007-01-01

On August 5, 2006, more than 300 South Carolina National Board Certified Teachers[R] (NBCTs) assembled in Columbia at a policy summit to address the vexing problem of recruiting and retaining accomplished teachers in high-needs schools. Before this summit, the NBCTs read a number of background papers and research summaries. During the summit, they…

76 FR 550 - Second National Bed Bug Summit; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0190; FRL-8858-4] Second National Bed Bug Summit... planning the second National Bed Bug Summit to be held February 1 and 2, 2011, on the topic of the bed bug resurgence in the United States. The goal of this meeting is to review the current bed bug problem and...

Defense.gov - Special Report - Travels With Gates

Science.gov Websites

/Photos Leaders DoD Web Sites Contact Us Shangri-La Dialogue: Asia Security Summit Alaska Visit – June Shangri-La Dialogue on Asia Security Summit, Singapore, May 30, 2009. DoD photo by U.S. Air Force Master Robert M. Gates opened the “Shangri-La Dialogue” Asia security summit outlining broad security issues

76 FR 47596 - Notice of Scientific Summit; The Science of Compassion-Future Directions in End-of-Life and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

...; The Science of Compassion--Future Directions in End-of-Life and Palliative Care SUMMARY: Notice is... science at the end-of-life. On August 11-12, the summit will feature keynote presentations, three plenary...), Department of Health and Human Services, will convene a scientific summit titled ``The Science of Compassion...

National Summit on Economic & Financial Literacy (Washington, DC, March 3, 2005). Executive Summary

ERIC Educational Resources Information Center

National Council on Economic Education (NJ3), 2005

2005-01-01

On March 3, 2005, a gathering of policy-shapers, thought-leaders and decision-makers met for The National Summit on Economic and Financial Literacy to promote the benefits of economic and financial literacy to individuals, families, businesses and communities. The ultimate goal of the Summit was to ensure that everyone has the real-life skills…

Winter Camp: A Blog from the Greenland Summit

NASA Technical Reports Server (NTRS)

Koenig, Lora

2009-01-01

This article presents the first half of the author's experience living and working at the National Science Foundation's (NSF) Greenland Summit Camp. The author is a remote-sensing glaciologist at NASA's Goddard Space Flight Center. She took measurements that will be used to validate data collected by NASA s Aqua, Terra, and Ice, Clouds, and land Elevation Satellite (ICESat) satellites with ground-truth measurements of the Greenland Ice Sheet she made at Summit Camp from November 2008-February 2009. This article presents excerpts from the second half of her stay and work at the Greenland Summit. The second half of the story is presented in another issue of this journal

Announcing Supercomputer Summit

ScienceCinema

Wells, Jack; Bland, Buddy; Nichols, Jeff; Hack, Jim; Foertter, Fernanda; Hagen, Gaute; Maier, Thomas; Ashfaq, Moetasim; Messer, Bronson; Parete-Koon, Suzanne

2018-01-16

Summit is the next leap in leadership-class computing systems for open science. With Summit we will be able to address, with greater complexity and higher fidelity, questions concerning who we are, our place on earth, and in our universe. Summit will deliver more than five times the computational performance of Titan’s 18,688 nodes, using only approximately 3,400 nodes when it arrives in 2017. Like Titan, Summit will have a hybrid architecture, and each node will contain multiple IBM POWER9 CPUs and NVIDIA Volta GPUs all connected together with NVIDIA’s high-speed NVLink. Each node will have over half a terabyte of coherent memory (high bandwidth memory + DDR4) addressable by all CPUs and GPUs plus 800GB of non-volatile RAM that can be used as a burst buffer or as extended memory. To provide a high rate of I/O throughput, the nodes will be connected in a non-blocking fat-tree using a dual-rail Mellanox EDR InfiniBand interconnect. Upon completion, Summit will allow researchers in all fields of science unprecedented access to solving some of the world’s most pressing challenges.

Improving Health, Social Welfare, and Human Development Through Women’s Empowerment in Developing Countries: The 2016 Girl Up Leadership Summit, Washington, DC, USA

PubMed Central

Mendoza, Janel

2016-01-01

The United Nations Foundation’s Girl Up campaign, an initiative dedicated to promoting the health, education, and leadership of adolescent girls in developing communities around the world, hosted its annual Girl Up Leadership Summit in Washington, DC from July 11-13, 2016. The summit welcomed more than 275 girl empowerment and women empowerment proponents to take part in leadership training, listen to and learn from influential figures like United Nations Deputy High Commissioner for Human Rights Kate Gilmore and Treasurer of the United States Rosie Rios, as well as engage in an official lobby day in the nation’s capital. Topics discussed at the summit ranged from the issue of child marriage and sexual and reproductive health rights to intersectional feminism and the importance of the next generation of global girl advocates. The purpose and, later on, achievement of the conference was the development of such leaders and Girl Up representatives. Summit attendee and Girl Up Campus Leader Janel Mendoza shares her experience as a longstanding Girl Up supporter and reflects on the preeminent conversations held during and following the summit. PMID:28058195

Improving Health, Social Welfare, and Human Development Through Women's Empowerment in Developing Countries: The 2016 Girl Up Leadership Summit, Washington, DC, USA.

PubMed

Mendoza, Janel

2016-01-01

The United Nations Foundation's Girl Up campaign, an initiative dedicated to promoting the health, education, and leadership of adolescent girls in developing communities around the world, hosted its annual Girl Up Leadership Summit in Washington, DC from July 11-13, 2016. The summit welcomed more than 275 girl empowerment and women empowerment proponents to take part in leadership training, listen to and learn from influential figures like United Nations Deputy High Commissioner for Human Rights Kate Gilmore and Treasurer of the United States Rosie Rios, as well as engage in an official lobby day in the nation's capital. Topics discussed at the summit ranged from the issue of child marriage and sexual and reproductive health rights to intersectional feminism and the importance of the next generation of global girl advocates. The purpose and, later on, achievement of the conference was the development of such leaders and Girl Up representatives. Summit attendee and Girl Up Campus Leader Janel Mendoza shares her experience as a longstanding Girl Up supporter and reflects on the preeminent conversations held during and following the summit.

b-value distribution in and around Mt. Tarumae, Japan

NASA Astrophysics Data System (ADS)

Chiba, K.

2017-12-01

Mt. Tarumae is an active volcano located in southeastern Shikotsu caldera, Hokkaido, Japan. Recently, crustal expansion occurred in 1999-2000 and 2013 near the summit of Mt. Tarumae, with a M5.6 earthquake recorded west of the summit on 8 July 2014. In this study, I determined hypocenter distributions and then performed b-value analysis for the period between 1 August 2014 and 12 August 2016 to improve our understanding of the magma system geometry beneath the summit of Mt. Tarumae. Hypocenters are mainly distributed in two regions: 3 - 5 km west of Mt. Tarumae, and beneath the volcano. I then determined b-value distributions. Regions with relatively high b-values ( 1.3) are located at depths of -0.5 to 2.0 km beneath the summit and at depths greater than 6.0 km in the northwestern part at about 1.5 - 3.0 km from the summit, while a region with relatively low b-values ( 0.6) is located at depths of 2.0 - 6.0 km beneath the summit. Compared the b-value distributions with other geophysical observations, it was found that the high b-value region from -0.5 to 2.0 km depth corresponds to regions of lower resistivity, positive self-potential anomaly, and an inflation source observed in 1999-2000. It is thus inferred that this region is generated by crustal heterogeneity, a decrease in effective normal stress, and change of a frictional property due to the development of faults and fissures, and the circulation of hydrothermal fluids. On the other hand, the inflation source observed in 2013 was located near the boundary between the low b-value region beneath the summit and the deeper high b-value region in the northwestern part at about 1.5 - 3.0 km from the summit. Studies of other volcanoes suggest that such a high-b-value region likely corresponds to a magma chamber. From the deeper high b-value region estimated in this study, I am able to point out that the magma chamber is located to depths greater than 6.0 km in the northwestern part at about 1.5 - 3.0 km from the summit. Thus, these findings contribute to our understanding of the magma plumbing system beneath the summit of Mt. Tarumae.

Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy.

PubMed

von Karstedt, Silvia; Montinaro, Antonella; Walczak, Henning

2017-05-24

The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study of pro-apoptotic TRAIL receptor (TRAIL-R) signalling and the development of biotherapeutic drug candidates that activate TRAIL-Rs. The outcome of clinical trials with these TRAIL-R agonists has, however, been disappointing so far. Recent evidence indicates that many cancers, in addition to being TRAIL resistant, use the endogenous TRAIL-TRAIL-R system to their own advantage. However, novel insight on two fronts - how resistance of cancer cells to TRAIL-based pro-apoptotic therapies might be overcome, and how the pro-tumorigenic effects of endogenous TRAIL might be countered - gives reasonable hope that the TRAIL system can be harnessed to treat cancer. In this Review we assess the status quo of our understanding of the biology of the TRAIL-TRAIL-R system - as well as the gaps therein - and discuss the opportunities and challenges in effectively targeting this pathway.

Argentine ant trail pheromone disruption is mediated by trail concentration.

PubMed

Suckling, David Maxwell; Stringer, Lloyd D; Corn, Joshua E

2011-10-01

Argentine ant trail pheromone disruption, using continuous release of the trail pheromone compound (Z)-9-hexadecanal, reduces the incidence of trails and foraging rates of field populations. However, little is known about the concentrations of pheromone required for successful disruption. We hypothesized that higher pheromone quantities would be necessary to disrupt larger ant populations. To test this, we laid a 30-cm long base trail of (Z)-9-hexadecanal on a glass surface at low and high rates (1 and 100 pg/cm) (Trail 1), and laid a second, shorter trail (Trail 2, 10 cm long, located 1.5 cm upwind) near the middle of Trail 1 at six rates (1, 10, 100, 1,000, 10,000, and 100,000 pg/cm). We then recorded and digitized movements of individual ants following Trail 1, and derived a regression statistic, r (2), as an index of trail integrity, and also recorded arrival success at the other end of the trail (30 cm) near a food supply. Disruption of trails required 100 fold more pheromone upwind, independent of base-trail concentration. This implies that in the field, trail disruption is likely to be less successful against high ant-trail densities (greater concentration of trail pheromone), and more successful against newly formed or weak trails, as could be expected along invasion fronts.

Resource allocation on the frontlines of public health preparedness and response: report of a summit on legal and ethical issues.

PubMed

Barnett, Daniel J; Taylor, Holly A; Hodge, James G; Links, Jonathan M

2009-01-01

In the face of all-hazards preparedness challenges, local and state health department personnel have to date lacked a discrete set of legally and ethically informed public health principles to guide the distribution of scarce resources in crisis settings. To help address this gap, we convened a Summit of academic and practice experts to develop a set of principles for legally and ethically sound public health resource triage decision-making in emergencies. The invitation-only Summit, held in Washington, D.C., on June 29, 2006, assembled 20 experts from a combination of academic institutions and nonacademic leadership, policy, and practice settings. The Summit featured a tabletop exercise designed to highlight resource scarcity challenges in a public health infectious disease emergency. This exercise served as a springboard for Summit participants' subsequent identification of 10 public health emergency resource allocation principles through an iterative process. The final product of the Summit was a set of 10 principles to guide allocation decisions involving scarce resources in public health emergencies. The principles are grouped into three categories: obligations to community; balancing personal autonomy and community well-being/benefit; and good preparedness practice. The 10 Summit-derived principles represent an attempt to link law, ethics, and real-world public health emergency resource allocation practices, and can serve as a useful starting framework to guide further systematic approaches and future research on addressing public health resource scarcity in an all-hazards context.

Repeated deflation-inflation events at Kilauea Volcano, Hawai'i: What's up (and down) with that?

NASA Astrophysics Data System (ADS)

Poland, M. P.; Miklius, A.; Lundgren, P.; Sutton, A. J.

2011-12-01

Cyclic deflation-inflation ("DI") events are a common occurrence at Kilauea Volcano. Most DI events begin with deflation at the summit that generally lasts 12-72 hours and accumulate ~1-5 microradians of tilt as measured on the rim of Kilauea caldera, followed by inflation that is initially rapid but wanes as the net deformation approaches pre-event levels over the course of 12-48 hours. In rare cases, the initial deflation is followed by large-magnitude (~20 microradians) inflation over a few hours followed by hours to days of deflation to pre-event levels. Such DID events have only been recorded during 2000-2004. DI events are also manifested at the Pu'u 'O'o eruptive vent on Kilauea's east rift zone, about 15 km from the summit, and lag summit deformation by about 1-2 hours. For DI events with relatively large-magnitudes (i.e., several microradians) and long-durations (i.e., several days), deformation is manifested along the east rift zone between Pu'u 'O'o and the summit, and eruptive activity at Pu'u 'O'o is impacted with long periods of deflation and inflation associated with eruptive pauses and surges, respectively. During a period of increased magma transport between the summit and Pu'u 'O'o in 2005-2007, DI events recorded at the summit were not detected at Pu'u 'O'o. Since the March 2008 start of Kilauea's ongoing summit eruption, the number of DI events per year has increased from about 5-10 to about 50-60. The level of the summit lava column (continuously visible since early 2010), has generally tracked DI deformation. Surface deformation associated with DI events is measured by tilt, GPS, and InSAR. At the summit, preliminary source models suggest a depth of 1-2 km and a sill-like geometry beneath the center of the caldera, with volume loss and subsequent recovery on the order of tens of thousands of cubic meters with each DI cycle. The localized nature of the DI signal at Pu'u 'O'o argues for a shallow source that is probably less than 1 km deep. At least two mechanisms are consistent with the occurrence of DI events at Kilauea. First, blockage and subsequent clearing of the transport pathway that feeds the shallow summit magma system and conduit to Pu'u 'O'o could cause the observed deformation. A second possibility is that DI events represent convective overturns caused by replacement of degassed magma with gas-rich magma. Such a model is consistent with the increased number of DI events following the onset of Kilauea's summit eruption, when summit gas emissions increased by a factor of about 5, but there have been no changes in degassing rates during periods of frequent (i.e., daily) or rare (i.e., monthly) DI events during 2008-2011. The source of DI events therefore remains a target of continued study.

Prognostic value of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors in renal cell cancer.

PubMed

Macher-Goeppinger, Stephan; Aulmann, Sebastian; Tagscherer, Katrin E; Wagener, Nina; Haferkamp, Axel; Penzel, Roland; Brauckhoff, Antje; Hohenfellner, Markus; Sykora, Jaromir; Walczak, Henning; Teh, Bin T; Autschbach, Frank; Herpel, Esther; Schirmacher, Peter; Roth, Wilfried

2009-01-15

The death ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors (TRAIL-R) are involved in immune surveillance and tumor development. Here, we studied a possible association between the expression of TRAIL/TRAIL-Rs and the prognosis in patients with renal cell carcinomas (RCC). A tissue microarray containing RCC tumor tissue samples and corresponding normal tissue samples from 838 patients was generated. Expression of TRAIL and TRAIL-Rs was examined by immunohistochemistry and the effect of TRAIL and TRAIL-R expression on disease-specific survival was assessed. High TRAIL-R2 expression levels were associated with high-grade RCCs (P < 0.001) and correlated negatively with disease-specific survival (P = 0.01). Similarly, high TRAIL expression was associated with a shorter disease-specific survival (P = 0.01). In contrast, low TRAIL-R4 expression was associated with high-stage RCCs (P < 0.001) as well as with the incidence of distant metastasis (P = 0.03) and correlated negatively with disease-specific survival (P = 0.02). In patients without distant metastasis, multivariate Cox regression analyses revealed that TRAIL-R2 and TRAIL are independent prognostic factors for cancer-specific survival (in addition to tumor extent, regional lymph node metastasis, grade of malignancy, and type of surgery). High TRAIL-R2, high TRAIL, and low TRAIL-R4 expression levels are associated with a worse disease-specific survival in patients with RCCs. Therefore, the assessment of TRAIL/TRAIL-R expression offers valuable prognostic information that could be used to select patients for adjuvant therapy studies. Moreover, our findings are of relevance for a potential experimental therapeutic administration of TRAIL-R agonists in patients with RCCs.

Summit on the National Effort To Prevent Mental Retardation and Related Disabilities. Summit Proceedings (Washington, D.C., February 6-7, 1991).

ERIC Educational Resources Information Center

President's Committee on Mental Retardation, Washington, DC.

This document reports the proceedings of a summit to assess the adequacy of the U.S. effort to prevent mental retardation and related disabilities and to chart the course for future strategies to reduce the incidence and ameliorate the effects of these disabilities, particularly when caused by socioeconomic conditions. The document contains…

Managing recreation on mountain summits in the northern forest region of Maine, New Hampshire, New York, and Vermont

Treesearch

Kelly Goonan; Robert Manning; Carena J. van Riper; Christopher Monz

2010-01-01

Land managers in the Northern Forest region of Maine, New Hampshire, New York, and Vermont face the challenge of providing high-quality recreation opportunities and experiences while also protecting fragile summit resources. The goals of this study were to identify indicators and standards of quality for visitor experiences and summit resources for three mountains with...

Foreword: Proceedings From the First Annual Lumbar Total Disc Replacement Summit.

PubMed

Blumenthal, Scott; Buttermann, Glenn; Garcia, Rolando; Gornet, Matthew; Grunch, Betsy; Guyer, Richard; Janssen, Michael; Kimball, Brent; Lewis, Adam; Mesiwala, Ali; Miller, Lynn; Morreale, Joseph; Reed, William; Sandhu, Faheem; Shackleford, Ian; Yue, James; Zigler, Jack; OConnell, Brent; Ferko, Nicole; Hollmann, Sarah

2017-12-15

: This publication focuses on proceedings from the First Annual Lumbar Total Disc Replacement Summit, held October 25, 2016 in Boston, MA. The Summit brought together 17 thought leading surgeons who employed a modified-Delphi method to determine where consensus existed pertaining to the utilization of lumbar total disc replacement as a standard of care for a subpopulation of patients suffering from degenerative disc disease.

Junior G8 Summit: Speaking Out with a "Passion for Peace"

ERIC Educational Resources Information Center

Education Canada, 2007

2007-01-01

The Junior G8 competition allows groups of young people from each of the G8 countries to have their voices heard on a global stage--the annual G8 summit. An international essay competition results in the selection of teams of students who travel to the G8 summit to provide a youth perspective on global issues. The 2006 competition focused on four…

Variations of Perspectives of Junior High School Students Who Have Participated in Smartphone Summit for Appropriate Usage of the Internet and Smartphones

ERIC Educational Resources Information Center

Miyake, Motoko; Takeuchi, Kazuo; Toda, Yuichi

2018-01-01

This study investigated the variations of perspectives of junior high school students who had participated in Smartphone Summit for appropriate usage of the Internet and smartphones. Smartphone Summit is an educational project designed to empower junior high school students to advocate appropriate usage of the Internet and smartphones among older,…

Talent Development Research, Policy, and Practice in Europe and the United States: Outcomes from a Summit of International Researchers

ERIC Educational Resources Information Center

Subotnik, Rena F.; Stoeger, Heidrun; Olszewski-Kubilius, Paula

2017-01-01

The goal of this article is to convey a summary of research and conversation on talent development on the part of a small group of European and American researchers who participated in the Inaugural American European Research Summit in Washington. In the final hours of the summit, participants discussed the state of research on talent development…

Correlates of Trail Use for Recreation and Transportation on 5 Massachusetts Trails.

PubMed

Orstad, Stephanie L; McDonough, Meghan H; Klenosky, David B; Mattson, Marifran; Troped, Philip J

2016-08-01

Promoting use of community trails is a recommended strategy for increasing population levels of physical activity. Correlates of walking and cycling for recreation or transportation differ, though few studies have compared correlates of trail-based physical activity for recreation and transportation purposes. This study examined associations of demographic, social, and perceived built environmental factors with trail use for recreation and transportation and whether associations were moderated by age, gender, and prior trail use. Adults (N = 1195) using 1 of 5 trails in Massachusetts responded to an intercept survey. We used multiple linear and logistic regression models to examine associations with trail use. Respondents' mean age was 44.9 years (standard deviation = 12.5), 55.3% were female, and 82.0% were white. Age (longer-term users only), trail use with others, travel time to the trail, and trail design were significantly associated with use for recreation (P < .05). Age, gender, trail safety (longer-term users only), travel time to the trail, trail design (younger users only), and trail beauty were associated with use for transportation (P < .05). Some common correlates were found for recreational and transportation trail use, whereas some variables were uniquely associated with use for 1 purpose. Tailored strategies are suggested to promote trail use for recreation and transportation.

Two magma bodies beneath the summit of Kīlauea Volcano unveiled by isotopically distinct melt deliveries from the mantle

NASA Astrophysics Data System (ADS)

Pietruszka, Aaron J.; Heaton, Daniel E.; Marske, Jared P.; Garcia, Michael O.

2015-03-01

The summit magma storage reservoir of Kīlauea Volcano is one of the most important components of the magmatic plumbing system of this frequently active basaltic shield-building volcano. Here we use new high-precision Pb isotopic analyses of Kīlauea summit lavas-from 1959 to the active Halema'uma'u lava lake-to infer the number, size, and interconnectedness of magma bodies within the volcano's summit reservoir. From 1971 to 1982, the 206Pb/204Pb ratios of the lavas define two separate magma mixing trends that correlate with differences in vent location and/or pre-eruptive magma temperature. These relationships, which contrast with a single magma mixing trend for lavas from 1959 to 1968, indicate that Kīlauea summit eruptions since at least 1971 were supplied from two distinct magma bodies. The locations of these magma bodies are inferred to coincide with two major deformation centers identified by geodetic monitoring of the volcano's summit region: (1) the main locus of the summit reservoir ∼2-4 km below the southern rim of Kīlauea Caldera and (2) a shallower magma body <2 km below the eastern rim of Halema'uma'u pit crater. Residence time modeling suggests that the total volume of magma within Kīlauea's summit reservoir during the late 20th century (1959-1982) was exceedingly small (∼0.1-0.5 km3). Voluminous Kīlauea eruptions, such as the ongoing, 32-yr old Pu'u 'Ō'ō rift eruption (>4 km3 of lava erupted), must therefore be sustained by a nearly continuous supply of new melt from the mantle. The model results show that a minimum of four compositionally distinct, mantle-derived magma batches were delivered to the volcano (at least three directly to the summit reservoir) since 1959. These melt inputs correlate with the initiation of energetic (1959 Kīlauea Iki) and/or sustained (1969-1974 Mauna Ulu, 1983-present Pu'u 'Ō'ō and 2008-present Halema'uma'u) eruptions. Thus, Kīlauea's eruptive behavior is partly tied to the delivery of new magma batches from the volcano's source region within the Hawaiian mantle plume.

Structure and Evolution of Hawaii's Loihi Seamount from High-resolution Mapping

NASA Astrophysics Data System (ADS)

Clague, D. A.; Paduan, J. B.; Moyer, C. L.; Glazer, B. T.; Caress, D. W.; Yoerger, D.; Kaiser, C. L.

2016-12-01

Loihi Seamount has been mapped repeatedly using shipboard multibeam sonars with improving resolution over time. Simrad EM302 data with 25m resolution at the 950m summit and 90m at the 5000m base of the volcano were collected from Schmidt Ocean Institute's R/V Falkor in 2014. A contracted multibeam survey in 1997 employing a deep-towed vehicle has 7m resolution for the summit and upper north and south rift zones, but suffered from poor navigation. Woods Hole Oceanographic Institution's AUV Sentry surveyed most of the summit and low-T hydrothermal vents on the base of the south rift in 2013 and 2014. The 2m resolution of most data is more precise than the navigation. The 6 summit surveys were reprocessed using MB-System to remove abundant bad bottom picks and adjust the navigation to produce a spatially accurate map. The 3 summit pits, including Pele's Pit that formed in 1996, are complex collapse structures and nested inside a larger caldera that was modified by large landslides on the east and west summit flanks. The pits cut low shields that once formed a complex of overlapping summit shields, similar to Kilauea before the current caldera formed 1500 to 1790 CE. An 11m section of ash deposits crops out on the east rim of the summit along a caldera-bounding fault and is analogous to Kilauea where the caldera-bounding faults expose ash erupted as the present caldera formed. Most of the Loihi ash section is 3300 to 5880 yr BP, indicating that the larger caldera structure at Loihi is younger than 3300 yr BP. The landslides on the east and west edges of the summit are therefore younger 3300 yr BP. The uppermost south rift has several small pit craters between cones and pillow ridges, also analogous to Kilauea. Two cones near the deep low-T vents are steep pillow mounds with slopes of talus. High-resolution mapping reveals, for the first time, the many similarities between the structure and evolution of submarine Loihi Seamount and subaerial Kilauea Volcano.

Wind-driven snow conditions control the occurrence of contemporary marginal mountain permafrost in the Chic-Choc Mountains, south-eastern Canada: a case study from Mont Jacques-Cartier

NASA Astrophysics Data System (ADS)

Davesne, Gautier; Fortier, Daniel; Domine, Florent; Gray, James T.

2017-06-01

We present data on the distribution and thermophysical properties of snow collected sporadically over 4 decades along with recent data of ground surface temperature from Mont Jacques-Cartier (1268 m a.s.l.), the highest summit in the Appalachians of south-eastern Canada. We demonstrate that the occurrence of contemporary permafrost is necessarily associated with a very thin and wind-packed winter snow cover which brings local azonal topo-climatic conditions on the dome-shaped summit. The aims of this study were (i) to understand the snow distribution pattern and snow thermophysical properties on the Mont Jacques-Cartier summit and (ii) to investigate the impact of snow on the spatial distribution of the ground surface temperature (GST) using temperature sensors deployed over the summit. Results showed that above the local treeline, the summit is characterized by a snow cover typically less than 30 cm thick which is explained by the strong westerly winds interacting with the local surface roughness created by the physiography and surficial geomorphology of the site. The snowpack structure is fairly similar to that observed on windy Arctic tundra with a top dense wind slab (300 to 450 kg m-3) of high thermal conductivity, which facilitates heat transfer between the ground surface and the atmosphere. The mean annual ground surface temperature (MAGST) below this thin and wind-packed snow cover was about -1 °C in 2013 and 2014, for the higher, exposed, blockfield-covered sector of the summit characterized by a sporadic herbaceous cover. In contrast, for the gentle slopes covered with stunted spruce (krummholz), and for the steep leeward slope to the south-east of the summit, the MAGST was around 3 °C in 2013 and 2014. The study concludes that the permafrost on Mont Jacques-Cartier, most widely in the Chic-Choc Mountains and by extension in the southern highest summits of the Appalachians, is therefore likely limited to the barren wind-exposed surface of the summit where the low air temperature, the thin snowpack and the wind action bring local cold surface conditions favourable to permafrost development.

Trail Transect: A Method for Documenting Trail Changes

Treesearch

R.E. Leonard; A.M. Whitney

1977-01-01

A trail transect that documents trail conditions and changes in trails has been used successfully over the past 3 years to measure soil loss, and changes in trail width and vegetation. The system also can be used to study the relationship between trail degradation and the physical characteristics of the site. Data from trail transects can be useful in determining the...

2012 ARPA-E Energy Innovation Summit: Profiling Sheetak: Low Cost - Solid State Cooling

ScienceCinema

Pokharna, Himanshu; Ghoshal, Uttam

2018-05-30

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These "performer videos" highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. Himanshu Pokharna, Vice President of Sheetak Uttam Ghoshal, President and CEO of Sheetak.

Lipid Nanoparticles Decorated with TNF-Related Aptosis-Inducing Ligand (TRAIL) Are More Cytotoxic than Soluble Recombinant TRAIL in Sarcoma.

PubMed

Gallego-Lleyda, Ana; De Miguel, Diego; Anel, Alberto; Martinez-Lostao, Luis

2018-05-13

Sarcomas are rare and heterogeneous cancers classically associated with a poor outcome. Sarcomas are 1% of the cancer but recent estimations indicate that sarcomas account for 2% of the estimated cancer-related deaths. Traditional treatment with surgery, radiotherapy, and chemotherapy has improved the outcome for some types of sarcomas. However, novel therapeutic strategies to treat sarcomas are necessary. TNF-related apoptosis-inducing ligand (TRAIL) is a death ligand initially described as capable of inducing apoptosis on tumor cell while sparing normal cells. Only few clinical trials have used TRAIL-based treatments in sarcoma, but they show only low or moderate efficacy of TRAIL. Consequently, novel TRAIL formulations with an improved TRAIL bioactivity are necessary. Our group has developed a novel TRAIL formulation based on tethering this death ligand on a lipid nanoparticle surface (LUV-TRAIL) resembling the physiological secretion of TRAIL as a trasmembrane protein inserted into the membrane of exosomes. We have already demonstrated that LUV-TRAIL shows an improved cytotoxic activity when compared to soluble recombinant TRAIL both in hematological malignancies and epithelial-derived cancers. In the present study, we have tested LUV-TRAIL in several human sarcoma tumor cell lines with different sensitivity to soluble recombinant TRAIL, finding that LUV-TRAIL was more efficient than soluble recombinant TRAIL. Moreover, combined treatment of LUV-TRAIL with distinct drugs proved to be especially effective, sensitizing even more resistant cell lines to TRAIL.

Deep magma body beneath the summit and rift zones of kilauea volcano, hawaii.

PubMed

Delaney, P T; Fiske, R S; Miklius, A; Okamura, A T; Sako, M K

1990-03-16

A magnitude 7.2 earthquake in 1975 caused the south flank of Kilauea Volcano, Hawaii, to move seaward in response to slippage along a deep fault. Since then, a large part of the volcano's edifice has been adjusting to this perturbation. The summit of Kilauea extended at a rate of 0.26 meter per year until 1983, the south flank uplifted more than 0.5 meter, and the axes of both the volcano's rift zones extended and subsided; the summit continues to subside. These ground-surface motions have been remarkably steady and much more widespread than those caused by either recurrent inflation and deflation of the summit magma chamber or the episodic propagation of dikes into the rift zones. Kilauea's magmatic system is, therefore, probably deeper and more extensive than previously thought; the summit and both rift zones may be underlain by a thick, near vertical dike-like magma system at a depth of 3 to 9 kilometers.

Deep magma body beneath the summit and rift zones of Kilauea Volcano, Hawaii

USGS Publications Warehouse

Delaney, P.T.; Fiske, R.S.; Miklius, Asta; Okamura, A.T.; Sako, M.K.

1990-01-01

A magnitude 7.2 earthquake in 1975 caused the south flank of Kilauea Volcano, Hawaii, to move seaward in response to slippage along a deep fault. Since then, a large part of the volcano's edifice has been adjusting to this perturbation. The summit of Kilauea extended at a rate of 0.26 meter per year until 1983, the south flank uplifted more than 0.5 meter, and the axes of both the volcano's rift zones extended and subsided; the summit continues to subside. These ground-surface motions have been remarkably steady and much more widespread than those caused by either recurrent inflation and deflation of the summit magma chamber or the episodic propagation of dikes into the rift zones. Kilauea's magmatic system is, therefore, probably deeper and more extensive than previously thought; the summit and both rift zones may be underlain by a thick, near vertical dike-like magma system at a depth of 3 to 9 kilometers.

Differences in the impacts of formal and informal recreational trails on urban forest loss and tree structure.

PubMed

Ballantyne, Mark; Pickering, Catherine Marina

2015-08-15

Recreational trails are one of the most common types of infrastructure used for nature-based activities such as hiking and mountain biking worldwide. Depending on their design, location, construction, maintenance and use, these trails differ in their environmental impacts. There are few studies, however, comparing the impacts of different trail types including between formal management-created trails and informal visitor-created trails. Although both types of trails can be found in remote natural areas, dense networks of them often occur in forests close to cities where they experience intense visitor use. To assess the relative impacts of different recreational trails in urban forests, we compared the condition of the trail surface, loss of forest strata and changes in tree structure caused by seven types of trails (total network 46.1 km) traversing 17 remnants of an endangered urban forest in Australia. After mapping and classifying all trails, we assessed their impact on the forest condition at 125 sites (15 sites per trail type, plus 15 control sites within undisturbed forest). On the trail sites, the condition of the trail surface, distance from the trail edge to four forest strata (litter, understory, midstorey and tree cover) and structure of the tree-line were assessed. Informal trails generally had poorer surface conditions and were poorly-designed and located. Per site, formal and informal trails resulted in similar loss of forest strata, with wider trails resulting in greater loss of forest. Because there were more informal trails, however, they accounted for the greatest cumulative forest loss. Structural impacts varied, with the widest informal trails and all formal hardened trails resulting in similar reductions in canopy cover and tree density but an increase in saplings. These structural impacts are likely a function of the unregulated and intense use of large informal trails, and disturbance from the construction and maintenance of formal trails. The results demonstrate that different types of recreational trails vary in the type and range of impacts they cause to forests. They highlight the importance of careful consideration towards management options when dealing with trail networks especially in areas of high conservation value. Copyright © 2015 Elsevier Ltd. All rights reserved.

SAHA-induced TRAIL-sensitisation of Multiple Myeloma cells is enhanced in 3D cell culture.

PubMed

Arhoma, A; Chantry, A D; Haywood-Small, S L; Cross, N A

2017-11-15

Multiple Myeloma (MM) is currently incurable despite many novel therapies. Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is a potential anti-tumour agent although effects as a single agent are limited. In this study, we investigated whether the Histone Deacetylase (HDAC) inhibitor SAHA can enhance TRAIL-induced apoptosis and target TRAIL resistance in both suspension culture, and 3D cell culture as a model of disseminated MM lesions that form in bone. The effects of SAHA and/or TRAIL in 6 Multiple Myeloma cell lines were assessed in both suspension cultures and in an Alginate-based 3D cell culture model. The effect of SAHA and/or TRAIL was assessed on apoptosis by assessment of nuclear morphology using Hoechst 33342/Propidium Iodide staining. Viable cell number was assessed by CellTiter-Glo luminescence assay, Caspase-8 and -9 activities were measured by Caspase-Glo™ assay kit. TRAIL-resistant cells were generated by culture of RPMI 8226 and NCI-H929 by acute exposure to TRAIL followed by selection of TRAIL-resistant cells. TRAIL significantly induced apoptosis in a dose-dependent manner in OPM-2, RPMI 8226, NCI-H929, U266, JJN-3 MM cell lines and ADC-1 plasma cell leukaemia cells. SAHA amplified TRAIL responses in all lines except OPM-2, and enhanced TRAIL responses were both via Caspase-8 and -9. SAHA treatment induced growth inhibition that further increased in the combination treatment with TRAIL in MM cells. The co-treatment of TRAIL and SAHA reduced viable cell numbers all cell lines. TRAIL responses were further potentiated by SAHA in 3D cell culture in NCI-H929, RPMI 8226 and U266 at lower TRAIL + SAHA doses than in suspension culture. However TRAIL responses in cells that had been selected for TRAIL resistance were not further enhanced by SAHA treatment. SAHA is a potent sensitizer of TRAIL responses in both TRAIL sensitive and resistant cell lines, in both suspension and 3D culture, however SAHA did not sensitise TRAIL-sensitive cell populations that had been selected for TRAIL-resistance from initially TRAIL-sensitive populations. SAHA may increase TRAIL sensitivity in insensitive cells, but not in cells that have specifically been selected for acquired TRAIL-resistance. Copyright © 2017 Elsevier Inc. All rights reserved.

2008 Munitions Executive Summit

DTIC Science & Technology

2008-02-21

7:00pm Hosted Reception 2008 Munitions Executive Summit February 20, 2008 – AGENDA (cont.) 8:00am Administrative Remarks 8:05am PEO Keynote Address...MES Awards Tuesday, February 19 5pm Reception /Pre-registration Sponsored by ATK Ammunition Systems Group and Kaman Aerospace’s Fuzing...15pm Adjourn 5:15pm - 7pm Hosted Reception Sponsored by DSE, Inc. and General Dynamics-OTS Munitions executive suMMit 2008 agenda & prograM

Exploring the Role of Performance Assessment in Competency-Based Education: Recommendations from the National Summit on K-12 Competency-Based Education

ERIC Educational Resources Information Center

Gagnon, Laurie

2017-01-01

Based on reports created for the 2017 National Summit on K-12 Competency-Based Education, this article explores how educators can take action to build momentum for and implement competency education and performance assessment. As a guide to taking action, the article provides the following: (1) links to the four framing reports from the Summit;…

Air quality real-time forecast before and during the G-20 Summit 2016 in Hangzhou with the WRF-CMAQ and WRF/Chem systems: Evaluation and Emission Reduction Effects

EPA Science Inventory

The 2016 G-20 Hangzhou summit, the eleventh annual meeting of the G-20 heads of government, will be held during September 3-5, 2016 in Hangzhou, China. For a successful summit, it is important to ensure good air quality. To achieve this goal, governments of Hangzhou and its surr...

Development and evaluation of a regional, large-scale interprofessional collaborative care summit.

PubMed

Foote, Edward F; Clarke, Virginia; Szarek, John L; Waters, Sharon K; Walline, Vera; Shea, Diane; Goss, Sheryl; Farrell, Marian; Easton, Diana; Dunleavy, Erin; Arscott, Karen

2015-01-01

The Northeastern/Central Pennsylvania Interprofessional Education Coalition (NECPA IPEC) is a coalition of faculty from multiple smaller academic institutions with a mission to promote interprofessional education. An interprofessional learning program was organized, which involved 676 learners from 10 different institutions representing 16 unique professions, and took place at seven different institutions simultaneously. The program was a 3-hour long summit which focused on the management of a patient with ischemic stroke. A questionnaire consisting of the Interprofessional Education Perception Scale (IEPS) questionnaire (pre-post summit), Likert-type questions, and open comment questions explored the learners' perceptions of the session and their attitudes toward interprofessional learning. Responses were analyzed using descriptive statistics and statistical tests for difference and qualitative thematic coding. The attitude of learners toward interprofessional education (as measured by the IEPS) was quite high even prior to the summit, so there were no significant changes after the summit. However, a high percentage of learners and facilitators agreed that the summit met its objective and was effective. In addition, the thematic analysis of the open-ended questions confirmed that students learned from the experience with a sense of the core competencies of interprofessional education and practice. A collaborative approach to delivering interprofessional learning is time and work intensive but beneficial to learners.

Massage therapy and canadians' health care needs 2020: proceedings of a national research priority setting summit.

PubMed

Dryden, Trish; Sumpton, Bryn; Shipwright, Stacey; Kahn, Janet; Reece, Barbara Findlay

2014-03-01

The health care landscape in Canada is changing rapidly as forces, such as an aging population, increasingly complex health issues and treatments, and economic pressure to reduce health care costs, bear down on the system. A cohesive national research agenda for massage therapy (MT) is needed in order to ensure maximum benefit is derived from research on treatment, health care policy, and cost effectiveness. A one-day invitational summit was held in Toronto, Ontario to build strategic alliances among Canadian and international researchers, policy makers, and other stakeholders to help shape a national research agenda for MT. Using a modified Delphi method, the summit organizers conducted two pre-summit surveys to ensure that time spent during the summit was relevant and productive. The summit was facilitated using the principles of Appreciative Inquiry which included a "4D" strategic planning approach (defining, discovery, dreaming, designing) and application of a SOAR framework (strengths, opportunities, aspirations, and results). Twenty-six researchers, policymakers, and other stakeholders actively participated in the events. Priority topics that massage therapists believe are important to the Canadian public, other health care providers, and policy makers and massage therapists themselves were identified. A framework for a national massage therapy (MT) research agenda, a grand vision of the future for MT research, and a 12-month action plan were developed. The summit provided an excellent opportunity for key stakeholders to come together and use their experience and knowledge of MT to develop a much-needed plan for moving the MT research and professionalization agenda forward.

Atrial Arrhythmias in Astronauts - Summary of a NASA Summit

NASA Technical Reports Server (NTRS)

Barr, Yael R.; Watkins, Sharmila D.; Polk, J. D.

2010-01-01

Background and Problem Definition: To evaluate NASA s current standards and practices related to atrial arrhythmias in astronauts, Space Medicine s Advanced Projects Section at the Johnson Space Center was tasked with organizing a summit to discuss the approach to atrial arrhythmias in the astronaut cohort. Since 1959, 11 cases of atrial fibrillation, atrial flutter, or supraventricular tachycardia have been recorded among active corps crewmembers. Most of the cases were paroxysmal, although a few were sustained. While most of the affected crewmembers were asymptomatic, those slated for long-duration space flight underwent radiofrequency ablation treatment to prevent further episodes of the arrhythmia. The summit was convened to solicit expert opinion on screening, diagnosis, and treatment options, to identify gaps in knowledge, and to propose relevant research initiatives. Summit Meeting Objectives: The Atrial Arrhythmia Summit brought together a panel of six cardiologists, including nationally and internationally renowned leaders in cardiac electrophysiology, exercise physiology, and space flight cardiovascular physiology. The primary objectives of the summit discussions were to evaluate cases of atrial arrhythmia in the astronaut population, to understand the factors that may predispose an individual to this condition, to understand NASA s current capabilities for screening, diagnosis, and treatment, to discuss the risks associated with treatment of crewmembers assigned to long-duration missions or extravehicular activities, and to discuss recommendations for prevention or management of future cases. Summary of Recommendations: The summit panel s recommendations were grouped into seven categories: Epidemiology, Screening, Standards and Selection, Treatment of Atrial Fibrillation Manifesting Preflight, Atrial Fibrillation during Flight, Prevention of Atrial Fibrillation, and Future Research

The Saint Louis River Idea-Slam crowd sourcing good ideas ...

EPA Pesticide Factsheets

As part of the 2017 Saint Louis River Summit, we propose hosting an “Idea-Slam” using software originally developed by the U.S. Consumer Financial Protection Bureau. Idea-box is an open source online app/website used to collect and surface ideas from members of an organization, or the public in general. Using the app, users login, view a request or challenge for new ideas, can submit their own ideas and/or view, comment and vote on other previously submitted ideas. Initially we will start with three idea request or “challenges” as listed below. The first will be run prior to the Summit to help generate additional challenges that might be added for the summit depending on the results. Initial Idea Challenges:1. (Prior to summit) If you could ask a large group of Saint Louis River focused scientist, stakeholders, managers, politicians and the public a question about the SLR, what would you ask?2. How might we better engage students and educators with the Saint Louis River?3. How might we employ citizen science for the Saint Louis River?The Idea-box app will be available for users two weeks before the Saint Louis Summit. We will e-mail previous summit participants and others an invitation to participate in “The Saint Louis River Idea-Slam” with clear instruction on how to proceed. During the morning of the first day at the Saint Louis Summit we will make a brief announcement about the Idea-Slam (< 2min.), and invite everyone to participate.

Massage Therapy and Canadians’ Health Care Needs 2020: Proceedings of a National Research Priority Setting Summit

PubMed Central

Dryden, Trish; Sumpton, Bryn; Shipwright, Stacey; Kahn, Janet; Reece, Barbara (Findlay)

2014-01-01

Background The health care landscape in Canada is changing rapidly as forces, such as an aging population, increasingly complex health issues and treatments, and economic pressure to reduce health care costs, bear down on the system. A cohesive national research agenda for massage therapy (MT) is needed in order to ensure maximum benefit is derived from research on treatment, health care policy, and cost effectiveness. Setting A one-day invitational summit was held in Toronto, Ontario to build strategic alliances among Canadian and international researchers, policy makers, and other stakeholders to help shape a national research agenda for MT. Method Using a modified Delphi method, the summit organizers conducted two pre-summit surveys to ensure that time spent during the summit was relevant and productive. The summit was facilitated using the principles of Appreciative Inquiry which included a “4D” strategic planning approach (defining, discovery, dreaming, designing) and application of a SOAR framework (strengths, opportunities, aspirations, and results). Participants Twenty-six researchers, policymakers, and other stakeholders actively participated in the events. Results Priority topics that massage therapists believe are important to the Canadian public, other health care providers, and policy makers and massage therapists themselves were identified. A framework for a national massage therapy (MT) research agenda, a grand vision of the future for MT research, and a 12-month action plan were developed. Conclusion The summit provided an excellent opportunity for key stakeholders to come together and use their experience and knowledge of MT to develop a much-needed plan for moving the MT research and professionalization agenda forward. PMID:24592299

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

PubMed Central

Dimberg, Lina Y.; Anderson, Charles K.; Camidge, Ross; Behbakht, Kian; Thorburn, Andrew; Ford, Heide L.

2015-01-01

TRAIL and agonistic antibodies against TRAIL death receptors kill tumor cells while causing virtually no damage to normal cells. Several novel drugs targeting TRAIL receptors are currently in clinical trials. However, TRAIL resistance is a common obstacle in TRAIL based therapy and limits the efficiency of these drugs. In this review article we discuss different mechanisms of TRAIL resistance and how they can be predicted and therapeutically circumvented. In addition, we provide a brief overview of all TRAIL based clinical trials conducted so far. It is apparent that although the effects of TRAIL therapy are disappointingly modest overall, a small subset of patients responds very well to TRAIL. We argue that the true potential of targeting TRAIL death receptors in cancer can only be reached when we find efficient ways to select for those patients that are most likely to benefit from the treatment. To achieve this, it is crucial to identify biomarkers that can help us predict TRAIL sensitivity. PMID:22580613

Chiliques volcano, Chile

NASA Technical Reports Server (NTRS)

2002-01-01

A January 6, 2002 ASTER nighttime thermal infrared image of Chiliques volcano in Chile shows a hot spot in the summit crater and several others along the upper flanks of the edifice, indicating new volcanic activity. Examination of an earlier nighttime thermal infrared image from May 24,2000 showed no thermal anomaly. Chiliques volcano was previously thought to be dormant. Rising to an elevation of 5778 m, Chiliques is a simple stratovolcano with a 500-m-diameter circular summit crater. This mountain is one of the most important high altitude ceremonial centers of the Incas. It is rarely visited due to its difficult accessibility. Climbing to the summit along Inca trails, numerous ruins are encountered; at the summit there are a series of constructions used for rituals. There is a beautiful lagoon in the crater that is almost always frozen.

The daytime image was acquired on November 19, 2000 and was created by displaying ASTER bands 1,2 and 3 in blue, green and red. The nighttime image was acquired January 6, 2002, and is a color-coded display of a single thermal infrared band. The hottest areas are white, and colder areas are darker shades of red. Both images cover an area of 7.5 x 7.5 km, and are centered at 23.6 degrees south latitude, 67.6 degrees west longitude.

Both images cover an area of 7.5 x 7.5 km, and are centered at 23.6 degrees south latitude, 67.6 degrees west longitude.

These images were acquired by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER will image Earth for the next 6 years to map and monitor the changing surface of our planet.

ASTER is one of five Earth-observing instruments launched December 18,1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products. Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, California, is the U.S. Science team leader; Bjorn Eng of JPL is the project manager. ASTER is the only high resolution imaging sensor on Terra. The Terra mission is part of NASA's Earth Science Enterprise, along-term research and technology program designed to examine Earth's land, oceans, atmosphere, ice and life as a total integrated system.

The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

Size: 7.5 x 7.5 km (4.5 x 4.5 miles) Location: 23.6 deg. South lat., 67.6 deg. West long. Orientation: North at top Image Data: ASTER bands 1,2, and 3, and thermal band 12 Original Data Resolution: 15 m and 90 m Date Acquired: January 6, 2002 and November 19, 2000

Global Variation of Meteor Trail Plasma Turbulence

NASA Technical Reports Server (NTRS)

Dyrud, L. P.; Hinrichs, J.; Urbina, J.

2011-01-01

We present the first global simulations on the occurrence of meteor trail plasma irregularities. These results seek to answer the following questions: when a meteoroid disintegrates in the atmosphere will the resulting trail become plasma turbulent, what are the factors influencing the development of turbulence, and how do they vary on a global scale. Understanding meteor trail plasma turbulence is important because turbulent meteor trails are visible as non-specular trails to coherent radars, and turbulence influences the evolution of specular radar meteor trails, particularly regarding the inference of mesospheric temperatures from trail diffusion rates, and their usage for meteor burst communication. We provide evidence of the significant effect that neutral atmospheric winds and density, and ionospheric plasma density have on the variability of meteor trail evolution and the observation of nonspecular meteor trails, and demonstrate that trails are far less likely to become and remain turbulent in daylight, explaining several observational trends using non-specular and specular meteor trails.

Advancements in adaptive aerodynamic technologies for airfoils and wings

NASA Astrophysics Data System (ADS)

Jepson, Jeffrey Keith

Although aircraft operate over a wide range of flight conditions, current fixed-geometry aircraft are optimized for only a few of these conditions. By altering the shape of the aircraft, adaptive aerodynamics can be used to increase the safety and performance of an aircraft by tailoring the aircraft for multiple flight conditions. Of the various shape adaptation concepts currently being studied, the use of multiple trailing-edge flaps along the span of a wing offers a relatively high possibility of being incorporated on aircraft in the near future. Multiple trailing-edge flaps allow for effective spanwise camber adaptation with resulting drag benefits over a large speed range and load alleviation at high-g conditions. The research presented in this dissertation focuses on the development of this concept of using trailing-edge flaps to tailor an aircraft for multiple flight conditions. One of the major tasks involved in implementing trailing-edge flaps is in designing the airfoil to incorporate the flap. The first part of this dissertation presents a design formulation that incorporates aircraft performance considerations in the inverse design of low-speed laminar-flow adaptive airfoils with trailing-edge cruise flaps. The benefit of using adaptive airfoils is that the size of the low-drag region of the drag polar can be effectively increased without increasing the maximum thickness of the airfoil. Two aircraft performance parameters are considered: level-flight maximum speed and maximum range. It is shown that the lift coefficients for the lower and upper corners of the airfoil low-drag range can be appropriately adjusted to tailor the airfoil for these two aircraft performance parameters. The design problem is posed as a part of a multidimensional Newton iteration in an existing conformal-mapping based inverse design code, PROFOIL. This formulation automatically adjusts the lift coefficients for the corners of the low-drag range for a given flap deflection as required for the airfoil-aircraft matching. Examples are presented to illustrate the flapped-airfoil design approach for a general aviation aircraft and the results are validated by comparison with results from post-design aircraft performance computations. Once the airfoil is designed to incorporate a TE flap, it is important to determine the most suitable flap angles along the wing for different flight conditions. The second part of this dissertation presents a method for determining the optimum flap angles to minimize drag based on pressures measured at select locations on the wing. Computational flow simulations using a panel method are used "in the loop" for demonstrating closed-loop control of the flaps. Examples in the paper show that the control algorithm is successful in correctly adapting the wing to achieve the target lift distributions for minimizing induced drag while adjusting the wing angle of attack for operation of the wing in the drag bucket. It is shown that the "sense-and-adapt" approach developed is capable of handling varying and unpredictable inflow conditions. Such a capability could be useful in adapting long-span flexible wings that may experience significant and unknown atmospheric inflow variations along the span. To further develop the "sense-and-adapt" approach, the method was tested experimentally in the third part of the research. The goal of the testing was to see if the same results found computationally can be obtained experimentally. The North Carolina State University subsonic wind tunnel was used for the wind tunnel tests. Results from the testing showed that the "sense-and-adapt" approach has the same performance experimentally as it did computationally. The research presented in this dissertation is a stepping stone towards further development of the concept, which includes modeling the system in the Simulink environment and flight experiments using uninhabited aerial vehicles.

Associations between sociodemographic characteristics and perceptions of the built environment with the frequency, type, and duration of physical activity among trail users.

PubMed

Maslow, Andréa L; Reed, Julian A; Price, Anna E; Hooker, Steven P

2012-01-01

Rail trails are elements of the built environment that support the Task Force on Community Preventive Services' recommendation to create, or enhance access to, places for physical activity (PA). The purpose of this study was to examine the associations between sociodemographic characteristics and perceptions of the built environment with the frequency, type, and duration of PA among users of an urban, paved rail trail segment. Interviewers conducted intercept surveys with 431 rail trail users and analyzed data by using logistic regression to estimate odds ratios between sociodemographic characteristics and perceptions of the built environment on the frequency, type, and duration of PA performed on the trail. Adults who used the trail in the cool months, traveled to the trail by a motorized vehicle, used the trail with others, and had some graduate school education visited the trail less often. Younger adults, men, whites, and those with some graduate school education were more likely to engage in vigorous activities on the trail. Adults who traveled to the trail by a motorized vehicle spent more time engaged in PA on the trail. Our results suggest that the most frequent users of a rail trail for PA are those who use the trail alone and travel to the trail by bicycle or on foot. Trails are an aspect of the built environment that supports active lifestyles, and future studies should evaluate different types of trails among more diverse populations and locations.

Comparing impacts between formal and informal recreational trails.

PubMed

Pickering, Catherine Marina; Norman, Patrick

2017-05-15

Globally there are hundreds of thousands of kilometres of recreational trails traversing natural areas of high conservation value: but what are their impacts and do impacts differ among trails? We compared the effects of four common types of recreational trails [(1) narrow and (2) medium width informal bare earth trails and (3) gravel and (4) tarmac/concrete formal trails] on vegetation adjacent to trails in a high conservation value plant community that is popular for mountain biking and hiking in Australia. Plant species composition was recorded in quadrats along the edge of the four types of trails and in control sites away from trails. Vegetation cover, the cover of individual growth forms, and species richness along the edges of all four types of trails were similar to the controls, although the wider trails affected plant composition, with the tarmac and gravel trails favouring different species. With very few comparative studies, more research is required to allow managers and researchers to directly compare differences in the severity and types of impacts on vegetation among trails. In the meantime, limiting damage to vegetation on the edge of hardened trails during construction, use and maintenance is important, and hardening trails may not always be appropriate. Copyright © 2016. Published by Elsevier Ltd.

Immunoglobulin Fc domain fusion to TRAIL significantly prolongs its plasma half-life and enhances its antitumor activity.

PubMed

Wang, Haizhen; Davis, Jennifer S; Wu, Xiangwei

2014-03-01

TRAIL (Apo2L) is a potent inducer of cell death. Interest in TRAIL has increased, following the observation that TRAIL can selectively kill a wide variety of human cancer cells without killing normal cells both in vitro and when grown as xenografts. Therefore, TRAIL has been proposed as a promising anticancer agent and currently is being tested in clinical trials. However, recombinant TRAIL has a very short plasma half-life, which limits its therapeutic potential. To overcome this limitation, we investigated the ability of the human IgG1 fragment crystallizable region (Fc) to enhance TRAIL stability. In this report, we show that Fc-TRAIL chimeric protein displays higher specific activity in vitro and a significantly longer half-life in mice than recombinant human TRAIL (rh-TRAIL). No short-term toxicity, especially liver toxicity, was observed. More importantly, Fc-TRAIL was much more effective in inhibiting tumor growth in a xenograft tumor model compared with rh-TRAIL. Our data suggest that fusion of Fc to TRAIL is able to improve the bioavailability and activity of TRAIL both in vitro and in vivo, and Fc-TRAIL may be explored for future clinical applications in cancer treatment and prevention. ©2014 AACR.

Association between thyroid hormones and TRAIL.

PubMed

Bernardi, Stella; Bossi, Fleur; Toffoli, Barbara; Giudici, Fabiola; Bramante, Alessandra; Furlanis, Giulia; Stenner, Elisabetta; Secchiero, Paola; Zauli, Giorgio; Carretta, Renzo; Fabris, Bruno

2017-11-01

Recent studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) might have a role in the regulation of body weight and metabolism. Interestingly, thyroid hormones seem to increase TRAIL tissue expression. This study aimed at evaluating whether overt thyroid disorders affected circulating TRAIL levels. TRAIL circulating levels were measured in euthyroid, hyperthyroid, and hypothyroid patients before and after thyroid function normalization. Univariate and multivariate analyses were performed to evaluate the correlation between thyroid hormones and TRAIL. Then, the stimulatory effect of both triiodothyronine (T3) and thyroxine (T4) on TRAIL was evaluated in vitro on peripheral blood mononuclear cells. Circulating levels of TRAIL significantly increased in hyperthyroid and decreased in hypothyroid patients as compared to controls. Once thyroid function was restored, TRAIL levels normalized. There was an independent association between TRAIL and both fT3 and fT4. Consistent with these findings, T3 and T4 stimulated TRAIL release in vitro. Here we show that thyroid hormones are associated with TRAIL expression in vivo and stimulate TRAIL expression in vitro. Given the overlap between the metabolic effects of thyroid hormones and TRAIL, this work sheds light on the possibility that TRAIL might be one of the molecules mediating thyroid hormones peripheral effects. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

The effect of a trail use intervention on urban trail use in Southern Nevada.

PubMed

Clark, Sheila; Bungum, Tim; Shan, Guogen; Meacham, Mindy; Coker, Lisa

2014-10-01

Communities are building or improving trail networks for biking and walking to encourage physical activity, but the relationship between trail environments and physical activity is not well understood. We examined the effect of a trail use intervention in Southern Nevada. We monitored the usage of urban trails (n=10) in Southern Nevada before, during, and after an intervention which included a marketing campaign promoting trail use and the addition of way-finding and incremental distance signage to selected trails (October 2011-October 2012). Data were collected with infrared monitors placed on the trails for three periods of 7days. We compared pre-, mid-, and post-intervention usage rates on the 6 trails where signage was added to usage rates on the 4 control trails. The groups of trails experienced different patterns of increases and decreases over the 1-year study period. Mean users per hour increased 31% for the study trails and 35% for the control trails (p<0.001), but the total increase did not vary between the groups. Trail use increased about 33% during the 1-year study period for the intervention. Adding wayfinding and incremental distance signage appeared to support the increase in usage which followed the marketing campaign. Copyright © 2014 Elsevier Inc. All rights reserved.

Summit Renovations, Inc. Information Sheet

EPA Pesticide Factsheets

Summit Renovations, Inc. (the Company) is located in Centennial, Colorado. The settlement involves renovation activities conducted at a property constructed prior to 1978, located in Denver, Colorado.

2012 ARPA-E Energy Innovation Summit: Profiling Sheetak: Low Cost - Solid State Cooling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pokharna, Himanshu; Ghoshal, Uttam

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These "performer videos" highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. Himanshu Pokharna,more » Vice President of Sheetak Uttam Ghoshal, President and CEO of Sheetak.« less

Hiking trails and tourism impact assessment in protected area: Jiuzhaigou Biosphere Reserve, China.

PubMed

Li, Wenjun; Ge, Xiaodong; Liu, Chunyan

2005-09-01

More and more visitors are attracted to protected areas nowadays, which not only bring about economic increase but also seriously adverse impacts on the ecological environment. In protected areas, trails are linkage between visitors and natural ecosystem, so they concentrate most of the adverse impacts caused by visitors. The trampling problems on the trails have been received attentions in the tremendous researches. However, few of them have correlated the environmental impacts to trail spatial patterns. In this project, the trails were selected as assessment objective, the trampling problems trail widening, multiple trail, and root exposure were taken as assessment indicators to assess ecological impacts in the case study area Jiuzhaigou Biosphere Reserve, and two spatial index, connectivity and circularity, were taken to indicate the trail network spatial patterns. The research results showed that the appearing frequency of the trampling problems had inverse correlation with the circularity and connectivity of the trail network, while the problem extent had no correlation with the spatial pattern. Comparing with the pristine trails, the artificial maintenance for the trails such as wooden trails and flagstone trails could prohibit vegetation root from exposure effectively. The research finds will be useful for the future trail design and tourism management.

Research for the development of best management practices for minimizing horse trail impacts on the Hoosier National Forest

USGS Publications Warehouse

Aust, M.W.; Marion, J.L.; Kyle, K.

2005-01-01

This research investigates horse trail impacts to gain an improved understanding of the relationship between various levels of horse use, horse trail management alternatives, and subsequent horse trail degradation. A survey of existing horse trails on the Hoosier National Forest was used to collect data on use-related, environmental and management factors to model horse trail impacts. Results are analyzed to identify which factors are most easily manipulated by managers to effectively avoid and minimize horse trail impacts. A specific focus includes evaluating the relative effect of trail use level, surfacing, grade, and water control on indices of erosion and trafficability such as trail cross sectional area, estimated erosion, muddiness, and incision. Overall, the Hoosier National Forest horse trails could be significantly improved by relocating or closing inherited trails that directly ascend slope or are excessively steep, reducing the distance between water control structures, and by applying gravel to harden trail surfaces and reduce soil erosion. A set of Best Management Practices for trails are included as a product of this work, with recommendations based on this research.

Trail impacts and trail impact management related to ecotourism visitation at Torres del Paine National Park, Chile

USGS Publications Warehouse

Farrell, T.A.; Marion, J.L.

2002-01-01

Ecotourism and protected area visitation in Central and South America are largely dependent upon a relatively undisturbed quality of natural resources. However, visitation may impact vegetation, soil, water and wildlife resources, and degrade visitor facilities such as recreation sites and trails. Findings are reported from trail impact research conducted at Torres del Paine National Park in Patagonia, Chile. The frequency and magnitude of selected trail impacts and the relative effect of the amount of use, vegetation type, trail position and trail grade are investigated. Findings differed from previous studies in that amount of use was significantly related to both trail width increases and trail erosion. Management actions to minimize trail impacts are offered.

Specificity of laboratory trail following by the argentine ant,Iridomyrmex humilis (Mayr), to (Z)-9-hexadecenal, analogs, and gaster extract.

PubMed

Van Vorhis Key, S E; Baker, T C

1982-07-01

In laboratory trail-following bioassays of Argentine ant workers,Iridomyrmex humilis (Mayr), the geometric isomer, (E)-9-hexadecenal, of the trail pheromone component (Z)-9-hexadecenal elicited insignificant trail following as did the potentially more stable formate analogs, (Z)-7-tetradecenyl formate, (E)-7-tetradecenyl formate, and tetradecyl formate. Further, in direct choice tests, workers showed no preference for gaster extract trails (0.002 ant equiv/cm) over trails of (Z)-9-hexadecenal (0.2 ng/cm). Moreover, a 10-fold increase in synthetic trail concentration to 2.0 ng/cm caused (Z)-9-hexadecenal trails to be significantly preferred over gaster extract trails by trail-following ants.

Lagrangian coherent structure analysis in the three-dimensional wake of a bio-inspired trapezoidal pitching panel

NASA Astrophysics Data System (ADS)

Kumar, Rajeev; King, Justin; Green, Melissa

2017-11-01

Three-dimensional Lagrangian analysis using the finite-time Lyapunov exponent (FTLE) field has been carried out on experimentally captured wake downstream of an oscillating trapezoidal panel. The trapezoidal geometry of the panel served as a simple model of a fish caudal fin. Three-dimensional FTLE isosurface appears as a shell wrapped around the wake vortex structures. A slice through the isosurfaces results in the familiar two-dimensional FTLE ridges. The attracting ridges (nFTLE) and the repelling ridges (pFTLE) are near-material lines and their intersections are analogous to topological saddle points in the flow field. A vortex-ring-based wake structure induces a streamwise momentum jet, evolution of which appears to be related to the timing of saddle point generation and behavior at the trailing edge. The time of release of these saddles at the trailing edge inside a pitching period appears to coincide with thrust extrema in similar experimental and numerical studies on foils and fins published in the literature. The merger of a pair of saddles from two consecutively shed vortices at a downstream location coincides with the occurrence of wake breakdown and precedes the formation of interconnected vortex loops and beginning of momentum-deficit zone in the time-averaged sense. This work was supported by the Office of Naval Research under ONR Award No. N00014-14-1-0418.

TRAIL-coated lipid-nanoparticles overcome resistance to soluble recombinant TRAIL in non-small cell lung cancer cells

NASA Astrophysics Data System (ADS)

De Miguel, Diego; Gallego-Lleyda, Ana; María Ayuso, José; Erviti-Ardanaz, Sandra; Pazo-Cid, Roberto; del Agua, Celia; José Fernández, Luis; Ochoa, Ignacio; Anel, Alberto; Martinez-Lostao, Luis

2016-05-01

Purpose. Non-small cell lung cancer (NSCLC) is one the types of cancer with higher prevalence and mortality. Apo2-Ligand/TRAIL is a TNF family member able to induce apoptosis in tumor cells but not in normal cells. It has been tested in clinical trials against different types of human cancer including NSCLC. However, results of clinical trials have shown a limited efficacy of TRAIL-based therapies. Recently we have demonstrated that artificial lipid nanoparticles coated with bioactive Apo2L/TRAIL (LUV-TRAIL) greatly improved TRAIL cytotoxic ability being capable of killing chemoresistant hematological cancer cells. In the present work we have extended the study to NSCLC. Methods/patients. LUV-TRAIL-induced cytotoxicity was assessed on different NSCLC cell lines with different sensitivity to soluble TRAIL and on primary human tumor cells from three patients suffering from NSCLC cancer. We also tested LUV-TRAIL-cytotoxic ability in combination with several anti-tumor agents. Results. LUV-TRAIL exhibited a greater cytotoxic effect compared to soluble TRAIL both in A549 cells and primary human NSCLC cells. LUV-TRAIL-induced cell death was dependent on caspase-8 and caspase-3 activation. Moreover, combination of LUV-TRAIL with other anti-tumor agents such as flavopiridol, and SNS-032 clearly enhanced LUV-TRAIL-induced cytotoxicity against NSCLC cancer cells. Conclusion. The novel formulation of TRAIL based on displaying it on the surface of lipid nanoparticles greatly increases its anti-tumor activity and has clinical potential in cancer treatment.

Characteristics of physical activity levels among trail users in a U.S. national sample.

PubMed

Librett, John J; Yore, Michelle M; Schmid, Thomas L

2006-11-01

The Task Force on Community Preventive Services strongly recommends environmental interventions that include enhanced access to opportunities for physical activity, such as walking and cycling trails. Although accumulating evidence indicates that trails can be effective in increasing physical activity, little is known about trail users. Cross-sectional analysis of a national sample of 3717 adults from the HealthStyles and ConsumerStyles surveys using logistic regression to determine physical activity patterns and sociodemographic correlates related to trail use, and to identify support regarding trail development policies. Almost 13% (12.7%) of the sample reported using trails at least once a month and 24.3% at least once a week. People who reported using trails at least once a week were twice as likely than people who reported rarely or never using trails to meet physical activity recommendations (odds ratio=2.3, 95% confidence interval=1.9-2.8). Nearly half (43.6%) of the non-trail users supported expanded public spaces for people to exercise, and 36.4% of the non-trail users reported that they would be willing to pay more taxes to build more parks and trails in their community. Community trails facilitate physical activity, and almost half of frequent trail users report that access to trails and other green space is important in choosing a place to live. These results support the need for prospective research on whether newly built trails promote physical activity in previously inactive people.

TRAIL-coated lipid-nanoparticles overcome resistance to soluble recombinant TRAIL in non-small cell lung cancer cells.

PubMed

De Miguel, Diego; Gallego-Lleyda, Ana; Ayuso, José María; Erviti-Ardanaz, Sandra; Pazo-Cid, Roberto; del Agua, Celia; Fernández, Luis José; Ochoa, Ignacio; Anel, Alberto; Martinez-Lostao, Luis

2016-05-06

Non-small cell lung cancer (NSCLC) is one the types of cancer with higher prevalence and mortality. Apo2-Ligand/TRAIL is a TNF family member able to induce apoptosis in tumor cells but not in normal cells. It has been tested in clinical trials against different types of human cancer including NSCLC. However, results of clinical trials have shown a limited efficacy of TRAIL-based therapies. Recently we have demonstrated that artificial lipid nanoparticles coated with bioactive Apo2L/TRAIL (LUV-TRAIL) greatly improved TRAIL cytotoxic ability being capable of killing chemoresistant hematological cancer cells. In the present work we have extended the study to NSCLC. LUV-TRAIL-induced cytotoxicity was assessed on different NSCLC cell lines with different sensitivity to soluble TRAIL and on primary human tumor cells from three patients suffering from NSCLC cancer. We also tested LUV-TRAIL-cytotoxic ability in combination with several anti-tumor agents. LUV-TRAIL exhibited a greater cytotoxic effect compared to soluble TRAIL both in A549 cells and primary human NSCLC cells. LUV-TRAIL-induced cell death was dependent on caspase-8 and caspase-3 activation. Moreover, combination of LUV-TRAIL with other anti-tumor agents such as flavopiridol, and SNS-032 clearly enhanced LUV-TRAIL-induced cytotoxicity against NSCLC cancer cells. The novel formulation of TRAIL based on displaying it on the surface of lipid nanoparticles greatly increases its anti-tumor activity and has clinical potential in cancer treatment.

Two magma bodies beneath the summit of Kilauea Volcano unveiled by isotopically distinct melt deliveries from the mantle

USGS Publications Warehouse

Pietruszka, Aaron J.; Heaton, Daniel E.; Marske, Jared P.; Garcia, Michael O.

2015-01-01

The summit magma storage reservoir of Kīlauea Volcano is one of the most important components of the magmatic plumbing system of this frequently active basaltic shield-building volcano. Here we use new high-precision Pb isotopic analyses of Kīlauea summit lavas—from 1959 to the active Halema‘uma‘u lava lake—to infer the number, size, and interconnectedness of magma bodies within the volcano's summit reservoir. From 1971 to 1982, the 206Pb/204Pb ratios of the lavas define two separate magma mixing trends that correlate with differences in vent location and/or pre-eruptive magma temperature. These relationships, which contrast with a single magma mixing trend for lavas from 1959 to 1968, indicate that Kīlauea summit eruptions since at least 1971 were supplied from two distinct magma bodies. The locations of these magma bodies are inferred to coincide with two major deformation centers identified by geodetic monitoring of the volcano's summit region: (1) the main locus of the summit reservoir ∼2–4 km below the southern rim of Kīlauea Caldera and (2) a shallower magma body <2 km below the eastern rim of Halema‘uma‘u pit crater. Residence time modeling suggests that the total volume of magma within Kīlauea's summit reservoir during the late 20th century (1959–1982) was exceedingly small (∼0.1–0.5 km3). Voluminous Kīlauea eruptions, such as the ongoing, 32-yr old Pu‘u ‘Ō‘ō rift eruption (>4 km3 of lava erupted), must therefore be sustained by a nearly continuous supply of new melt from the mantle. The model results show that a minimum of four compositionally distinct, mantle-derived magma batches were delivered to the volcano (at least three directly to the summit reservoir) since 1959. These melt inputs correlate with the initiation of energetic (1959 Kīlauea Iki) and/or sustained (1969–1974 Mauna Ulu, 1983-present Pu‘u ‘Ō‘ō and 2008-present Halema‘uma‘u) eruptions. Thus, Kīlauea's eruptive behavior is partly tied to the delivery of new magma batches from the volcano's source region within the Hawaiian mantle plume.

Port Stakeholder Summit - April 2014

EPA Pesticide Factsheets

EPA's National Port Stakeholders Summit, Advancing More Sustainable Ports, focused on actions to protect air quality while reducing climate risk and supporting economic growth, making ports more environmentally sustainable.

Kilauea summit overflows: Their ages and distribution in the Puna District, Hawai'i

USGS Publications Warehouse

Clague, D.A.; Hagstrum, J.T.; Beeson, M.H.; Champion, D.E.

1999-01-01

The tube-fed pahoehoe lava flows covering much of the northeast flank of Kilauea Volcano are named the 'Aila'au flows. Their eruption age, based on published and six new radiocarbon dates, is approximately AD 1445. The flows have distinctive paleomagnetic directions with steep inclinations (40??-50??) and easterly declinations (0??-10??E). The lava was transported ~40 km from the vent to the coast in long, large-diameter lava tubes; the longest tube (Kazumura Cave) reaches from near the summit to within several kilometers of the coast near Kaloli Point. The estimated volume of the 'Aila'au flow field is 5.2 ?? 0.8 km3, and the eruption that formed it probably lasted for approximately 50 years. Summit overflows from Kilauea may have been nearly continuous between approximately AD 1290 and 1470, during which time a series of shields formed at and around the summit. The 'Aila'au shield was either the youngest or the next to youngest in this series of shields. Site-mean paleomagnetic directions for lava flows underlying the 'Aila'au flows form only six groups. These older pahoehoe flows range in age from 2750 to 2200 years. Lava flows from most of these summit eruptions also reached the coast, but none appears as extensive as the 'Aila'au flow field. The chemistry of the melts erupted during each of these summit overflow events is remarkably similar, averaging approximately 6.3 wt.% MgO near the coast and 6.8 wt.% MgO near the summit. The present-day caldera probably formed more recently than the eruption that formed the 'Aila'au flows (estimated termination ca. AD 1470). The earliest explosive eruptions that formed the Keanakako'i Ash, which is stratigraphically above the 'Aila'au flows, cannot be older than this age.

Ground Tilt Time Delays between Kilauea Volcano's Summit and East Rift Zone Caused by Magma Reservoir Buffering

NASA Astrophysics Data System (ADS)

Haney, M. M.; Patrick, M. R.; Anderson, K. R.

2016-12-01

A cyclic pattern of ground deformation, called a deflation-inflation (DI) cycle, is commonly observed at Kilauea Volcano, Hawai`i. These cycles are an important part of Kilauea's eruptive activity because they directly influence the level of the summit lava lake as well as the effusion rate (and resulting lava flow hazard) at the East Rift Zone eruption site at Pu`u `O`o. DI events normally span several days, and are measured both at the summit and at Pu`u `O`o cone (20 km distance). Signals appear first at the summit and are then observed at Pu`u `O`o after an apparent delay of between 0.5 and 10 hours, which has been previously interpreted as reflecting magma transport time. We propose an alternate explanation, in which the apparent delay is an artifact of buffering by the small magma reservoir thought to exist at Pu`u `O`o. Simple Poiseuille flow modeling demonstrates that this apparent delay can be reproduced by the changing balance of inflow (from the summit) and outflow (to surface lava flows) at the Pu`u `O`o magma reservoir. The apparent delay is sensitive to the geometry of the conduit leaving Pu`u `O`o, feeding surface lava flows. We demonstrate how the reservoir buffering is quantitatively equivalent to a causal low-pass filter, which explains both the apparent delay as well as the smoothed, skewed nature of the signal at Pu`u `O`o relative to the summit. By comparing summit and Pu`u `O`o ground tilt signals over an extended time period, it may be possible to constrain the changing geometry of the shallow magmatic system through time.

Distribution of epibenthic megafauna and lebensspuren on two central North Pacific seamounts

NASA Astrophysics Data System (ADS)

Kaufmann, Ronald S.; Wakefield, W. Waldo; Genin, Amatzia

1989-12-01

The abundance, composition and spatial distribution of megafaunal communities and lebensspuren assemblages at three sites on two deep seamounts in the central North Pacific were surveyed photographically using still cameras mounted on the research submersible Alvin. Photographic transects were made on the summit cap (˜1500 m depth) and summit perimeter (˜ 1800 m depth) of Horizon Guyot and on the summit cap (˜3100 m depth) of Magellan Rise. The summit caps of both seamounts were covered with foraminiferal sand, while the summit perimeter of Horizon Guyot was characterized by numerous rock outcroppings (basalt and chert encrusted with ferromanganese oxides) on which was situated a speciose assemblage of suspension-feeding organisms. The most abundant megafauna at all three sites were large, sediment-agglutinating protists belonging to the class Xenophyophorea. Among the three sites, the Horizon Guyot summit cap supported the highest densities of fishes and lebensspuren and the fewest echinoderms, while the Magellan Rise summit cap was populated by a diverse community of deposit-feeding echinoderms. Megafaunal abundances on Horizon Guyot were lower than those at equivalent depths on the western North Atlantic continental slope, while those on Magellan Rise were higher. The faunal differences observed between the two seamounts were attributed primarily to differences in hydrodynamic conditions, substrate availability and nutrient availability. Most of the lebensspuren on these seamounts appeared to be patchily distributed on spatial scales of 10-1000 m, while xenophyophore distributions were predominantly random on the same spatial scales. Biogeographically the species identified exhibited predominantly widespread to cosmopolitan distributions with Indo-West Pacific faunal affinities, typical of other seamounts in the same depth range and biogeographic province.

Proceedings of the November 2011 Traceability Research Summit: this report is the third in a series on Traceability Summits sponsored by IFT beginning in July 2011.

PubMed

Hickey, Caitlin; Bhatt, Tejas

2013-12-01

Fifty thought leaders in the area of food traceability met for a 3rd time to discuss methodologies and finalize the principles that define their vision for traceability. Participants in the summit included representatives from industry, trade associations, government, academia, consumer groups, and more. One main focus of this summit included a discussion on the current regulations and voluntary initiatives in place regarding traceability. Overall, it was recognized that the recommendations from this summit group would be more specific and stringent in comparison to these current regulations and initiatives. The participants sought to be leaders in the traceability arena, with their recommendations leading the industry to optimal traceability systems and methods. Participants agreed on many principles for their vision of traceability, emphasizing the importance of access to traceability data. They discussed having industry be asked for "basic" tracing data prior to the need for a large-scale investigation, having standards for sharing data, and having the data in electronic form. Participants foresaw the importance of capturing data electronically in the future, although they recognized that many firms do not currently do this. The group also saw a need for a transition period to implement changes, and to provide implementation training and resource aid to small businesses. Summit participants discussed specific definitions and examples for key data elements and critical tracking events that could be used by industry to capture tracing data at specific points within the supply chain. Overall, participants refined the goals of the summit group and started to identify specific ways to achieve those goals. © 2013 Institute of Food Technologists®

Geologic Map of the Summit Region of Kilauea Volcano, Hawaii

USGS Publications Warehouse

Neal, Christina A.; Lockwood, John P.

2003-01-01

This report consists of a large map sheet and a pamphlet. The map shows the geology, some photographs, description of map units, and correlation of map units. The pamphlet gives the full text about the geologic map. The area covered by this map includes parts of four U.S. Geological Survey 7.5' topographic quadrangles (Kilauea Crater, Volcano, Ka`u Desert, and Makaopuhi). It encompasses the summit, upper rift zones, and Koa`e Fault System of Kilauea Volcano and a part of the adjacent, southeast flank of Mauna Loa Volcano. The map is dominated by products of eruptions from Kilauea Volcano, the southernmost of the five volcanoes on the Island of Hawai`i and one of the world's most active volcanoes. At its summit (1,243 m) is Kilauea Crater, a 3 km-by-5 km collapse caldera that formed, possibly over several centuries, between about 200 and 500 years ago. Radiating away from the summit caldera are two linear zones of intrusion and eruption, the east and the southwest rift zones. Repeated subaerial eruptions from the summit and rift zones have built a gently sloping, elongate shield volcano covering approximately 1,500 km2. Much of the volcano lies under water; the east rift zone extends 110 km from the summit to a depth of more than 5,000 m below sea level; whereas the southwest rift zone has a more limited submarine continuation. South of the summit caldera, mostly north-facing normal faults and open fractures of the Koa`e Fault System extend between the two rift zones. The Koa`e Fault System is interpreted as a tear-away structure that accommodates southward movement of Kilauea's flank in response to distension of the volcano perpendicular to the rift zones.

77 FR 39733 - Proposed Information Collection; Comment Request: Appalachian Trail Management Partner Survey

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

... Collection; Comment Request: Appalachian Trail Management Partner Survey AGENCY: National Park Service (NPS... the Appalachian Trail Park Office (ATPO) to protect trail resources and provide for the public enjoyment and visitor experience of the Appalachian National Scenic Trail (Trail). To comply with the...

36 CFR 212.21 - Pacific Crest National Scenic Trail.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Trail. 212.21 Section 212.21 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... National Scenic Trail. The Pacific Crest National Scenic Trail as defined by the National Trails Systems Act, 82 Stat. 919, shall be administered primarily as a footpath and horseback riding trail by the...

Targeting Death Receptor TRAIL-R2 by Chalcones for TRAIL-Induced Apoptosis in Cancer Cells

PubMed Central

Szliszka, Ewelina; Jaworska, Dagmara; Kłósek, Małgorzata; Czuba, Zenon P.; Król, Wojciech

2012-01-01

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells without toxicity to normal cells. TRAIL binds to death receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) expressed on cancer cell surface and activates apoptotic pathways. Endogenous TRAIL plays an important role in immune surveillance and defense against cancer cells. However, as more tumor cells are reported to be resistant to TRAIL mediated death, it is important to search for and develop new strategies to overcome this resistance. Chalcones can sensitize cancer cells to TRAIL-induced apoptosis. We examined the cytotoxic and apoptotic effects of TRAIL in combination with four chalcones: chalcone, isobavachalcone, licochalcone A and xanthohumol on HeLa cancer cells. The cytotoxicity was measured by MTT and LDH assays. The apoptosis was detected using annexin V-FITC staining by flow cytometry and fluorescence microscopy. Death receptor expression was analyzed using flow cytometry. The decreased expression of death receptors in cancer cells may be the cause of TRAIL-resistance. Chalcones enhance TRAIL-induced apoptosis in HeLa cells through increased expression of TRAIL-R2. Our study has indicated that chalcones augment the antitumor activity of TRAIL and confirm their cancer chemopreventive properties. PMID:23203129

Summit Crater of Mauna Loa

NASA Technical Reports Server (NTRS)

2002-01-01

Astronauts obtained this detailed image of the summit caldera of Mauna Loa volcano, called Mokuaweoweo Caldera. Mauna Loa is the largest volcano on our planet-the summit elevation is 4,170 m (over 13,600 ft), but the volcano's summit rises 9 km above the sea floor. The sharp features of the summit caldera and lava flows that drain outward from the summit are tribute to the fact that Mauna Loa is one of the Earth's most active volcanoes. The most recent eruption was in 1984. The straight line the cuts through the center of the crater from top to bottom is a rift zone-an area that pulls apart as magma reaches the surface. A weather observatory run by NOAA's Climate Monitoring and Diagnostics Lab is on the volcano's north slope at 11,000 ft (3397 m). This facility, known as the Mauna Loa Observatory, is the site where scientists have documented the constantly increasing concentrations of global atmospheric carbon dioxide. Other resources about Mauna Loa: http://wwwhvo.wr.usgs.gov/maunaloa/ http://www.cmdl.noaa.gov/obop/mlo/ http://www.volcano.si.edu/gvp/usgs/vol_archive/maunaloa.htm Astronaut photograph ISS005-E-7002 was provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography of Earth.

Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells.

PubMed

Kim, Seok-Hyun; Kim, Kunhong; Kwagh, Jae G; Dicker, David T; Herlyn, Meenhard; Rustgi, Anil K; Chen, Youhai; El-Deiry, Wafik S

2004-09-17

The cytotoxic death ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a tumor-specific agent under development as a novel anticancer therapeutic agent. However, some reports have demonstrated toxicity of certain TRAIL preparations toward human hepatocytes and keratinocytes through a caspase-dependent mechanism that involves activation of the extrinsic death pathway and Type II signaling through the mitochondria. We have isolated and purified both His-tagged protein and three versions of native recombinant human TRAIL protein from Escherichia coli. We found that 5 mm dithiothreitol in the purification process enhanced oligomerization of TRAIL and resulted in the formation of hyper-oligomerized TRAILs, including hexamers and nonomers with an extremely high potency in apoptosis induction. Although death-inducing signaling complex formation was much more efficient in cells treated with hyper-oligomerized TRAILs, this did not convert TRAIL-sensitive Type II HCT116 colon tumor cells to a Type I death pattern as judged by their continued sensitivity to a caspase 9 inhibitor. Moreover, TRAIL-resistant Type II Bax-null colon carcinoma cells were not converted to a TRAIL-sensitive Type I state by hyper-oligomerized TRAIL. Primary human esophageal epithelial 2 cells were found to be sensitive to all TRAIL preparations used, including trimer TRAIL. TRAIL-induced death in esophageal epithelial 2 cells was prevented by caspase 9 inhibition for up to 4 h after TRAIL exposure. This result suggests a possible therapeutic application of caspase 9 inhibition as a strategy to reverse TRAIL toxicity. Hyper-oligomerized TRAIL may be considered as an alternative agent for testing in clinical trials.

TRAIL Death Receptor-4 Expression Positively Correlates With the Tumor Grade in Breast Cancer Patients With Invasive Ductal Carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanlioglu, Ahter D.; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya; Korcum, Aylin F.

2007-11-01

Purpose: Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) selectively induces apoptosis in cancer cells but not in normal cells, and a number of clinical trials have recently been initiated to test the safety and antitumoral potential of TRAIL in cancer patients. Four different receptors have been identified to interact with TRAIL: two are death-inducing receptors (TRAIL-R1 [DR4] and TRAIL-R2 [DR5]), whereas the other two (TRAIL-R3 [DcR1] and TRAIL-R4 [DcR2]) do not induce death upon ligation and are believed to counteract TRAIL-induced cytotoxicity. Because high levels of DcR2 expression have recently been correlated with carcinogenesis in the prostate and lung, thismore » study investigated the importance of TRAIL and TRAIL receptor expression in breast cancer patients with invasive ductal carcinoma, taking various prognostic markers into consideration. Methods and Materials: Immunohistochemical analyses were performed on 90 breast cancer patients with invasive ductal carcinoma using TRAIL and TRAIL receptor-specific antibodies. Age, menopausal status, tumor size, lymph node status, tumor grade, lymphovascular invasion, perineural invasion, extracapsular tumor extension, presence of an extensive intraductal component, multicentricity, estrogen and progesterone receptor status, and CerbB2 expression levels were analyzed with respect to TRAIL/TRAIL receptor expression patterns. Results: The highest TRAIL receptor expressed in patients with invasive ductal carcinoma was DR4. Although progesterone receptor-positive patients exhibited lower DR5 expression, CerbB2-positive tissues displayed higher levels of both DR5 and TRAIL expressions. Conclusions: DR4 expression positively correlates with the tumor grade in breast cancer patients with invasive ductal carcinoma.« less

Improving the health status of Caribbean people: recommendations from the Triangulating on Health Equity summit.

PubMed

Sastre, Francisco; Rojas, Patria; Cyrus, Elena; De La Rosa, Mario; Khoury, Aysha H

2014-09-01

In 2011, Morehouse School of Medicine convened a summit in San Juan, Puerto Rico, to discuss issues related to the health status of people and communities in the Caribbean region. The summit provided a forum for transparent dialog among researchers, policymakers, and advocates from the Caribbean region and the United States. The summit's theme-improving the region's health outcomes through the adoption of effective practices linking health promotion and primary care, within the context of social and cultural determinants-called for a comprehensive and integrative model or a triangulation of methodologies to improve health outcomes. This article summarizes the recommendations of two workgroup sessions examining the challenges to improving health outcomes in the region and the opportunities to meet those challenges. The recommendations seek to develop action-oriented agendas that integrate research, practice, and policy. Outcomes of the summit highlight the importance of (a) community participation in planning interventions, (b) policymakers' commitment to prioritizing health, and (c) Caribbean governments' commitment to addressing the underlying social factors responsible for poor health outcomes. © The Author(s) 2014.

Academy of Osseointegration's Summit on Clinical Practice Guidelines for the Edentulous Maxilla: Overview, Process, and Outcomes-Changing the Face of Implant Dentistry.

PubMed

Stanford, Clark M

2016-01-01

Starting in 2012, the Academy of Osseointegration initiated the planning process for an AO Summit to develop clinical practice guidelines (CPGs) for management of the edentulous maxilla. A planning committee led by Professor Clark Stanford and Dr Ole Jensen created a work plan based on five domain areas to be addressed by the summit. The five domain areas were defined as: (1) role of grafting for ridge development for implant placement, (2) role of implant design and systems in management of the edentulous maxilla, (3) role of imaging to guide implant placement, (4) role of biologics to assist in ridge development, and (5) role of prosthetic management. The summit was held in August 2014, and the results are presented in this overview. All of the supporting systematic reviews and the detailed CPGs are presented in this special edition of JOMI. While the evidence was observed to be weak in regard to the literature for most of the systematic reviews, the summit strived to establish the current best evidence and practical CPGs that will assist clinicians in practice.

Trails and physical activity: a review.

PubMed

Starnes, Heather A; Troped, Philip J; Klenosky, David B; Doehring, Angela M

2011-11-01

To provide a synthesis of research on trails and physical activity from the public health, leisure sciences, urban planning, and transportation literatures. A search of databases was conducted to identify studies published between 1980 and 2008. 52 studies were identified. The majority were cross-sectional (92%) and published after 1999 (77%). The evidence for the effects of trails on physical activity was mixed among 3 intervention and 5 correlational studies. Correlates of trail use were examined in 13 studies. Several demographic (eg, race, education, income) and environmental factors (eg, land-use mix and distance to trail) were related to trail use. Evidence from 31 descriptive studies identified several facilitators and barriers to trail use. Economic studies (n = 5) examining trails in terms of health or recreational outcomes found trails are cost-effective and produce significant economic benefits. There is a growing body of evidence demonstrating important factors that should be considered in promoting trail use, yet the evidence for positive effects of trails on physical activity is limited. Further research is needed to evaluate the effects of trails on physical activity. In addition, trail studies that include children and youth, older adults, and racial and ethnic minorities are a research priority.

Photo-excitable hybrid nanocomposites for image-guided photo/TRAIL synergistic cancer therapy.

PubMed

Lin, Gan; Zhang, Yang; Zhu, Congqing; Chu, Chengchao; Shi, Yesi; Pang, Xin; Ren, En; Wu, Yayun; Mi, Peng; Xia, Haiping; Chen, Xiaoyuan; Liu, Gang

2018-05-22

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in cancer cells without toxicity to normal cells. However, the efficiency is greatly limited by its short half-life and wild resistance in various cancer cells. In this study, we reported a micellar hybrid nanoparticle to carry TRAIL ligand (denoted as IPN@TRAIL) for a novel photo-excited TRAIL therapy. These IPN@TRAIL offered increased TRAIL stability, prolonged half-life and enhanced tumor accumulation, monitored by dual mode imaging. Furthermore, IPN@TRAIL nanocomposites enhanced wrapped TRAIL therapeutic efficiency greatly towards resistant cancer cells by TRAIL nanovectorization. More importantly, when upon external laser, these nanocomposites not only triggered tumor photothermal therapy (PTT), but also upregulated the expression of death receptors (DR4 and DR5), resulting in a greater apoptosis mediated by co-delivered TRAIL ligand. Such photo/TRAIL synergistic effect showed its great killing effects in a controllable manner on TRAIL-resistant A549 tumor model bearing mice. Finally, these nanocomposites exhibited rapid clearance without obvious systemic toxicity. All these features rendered our nanocomposites a promising theranostic platform in cancer therapy. Copyright © 2018 Elsevier Ltd. All rights reserved.

National Tribal Building Codes Summit

EPA Pesticide Factsheets

National Tribal Building Codes summit statement developed to support tribes interested in adopting green and culturally-appropriate building systems to ensure safe, sustainable, affordable, and culturally-appropriate buildings on tribal lands.

Gas-rich submarine exhalations during the 1989 eruption of Macdonald Seamount

NASA Astrophysics Data System (ADS)

C´e, J.-L.; Stoffers, P.; McMurtry, G.; Richnow, H.; Puteanus, D.; Sedwick, P.

1991-11-01

In January 1989 we observed submarine eruptions on the summit of Macdonald volcano during a French-German diving programme with the IFREMER submersible Cyana. Gas-streaming of large amounts of CH 4, CO 2 and SO 2 from summit vents, inferred from water column anomalies and observed by submersible, was accompanied on the sea surface by steam bursts, turbulence, red-glowing gases, and black bubbles comprising volcanic ash, sulphur and sulphides. Chloride depletion of water sampled on the floor of an actively degassing summit crater suggests either boiling and phase separation or additions of magmatic water vapour. Submersible observations, in-situ sampling and shipboard geophysical and hydrographic measurements show that the hydrothermal system of this hotspot volcano is distinguished by the influence of magmatic gases released from its shallow summit.

Industry progress report on neuro-oncology: Biotech update 2013.

PubMed

Ottenhausen, Malte; Bodhinayake, Imithri; Banu, Matei; Kesavabhotla, Kartik; Ray, Ashley; Boockvar, John A

2013-11-01

For the second time, The Brain Tumor Center of the Weill Cornell Brain and Spine Center, in collaboration with Voices Against Brain Cancer, hosted The Brain Tumor Biotech Summit in New York City in June 2013. After a very successful first summit in 2012, this innovative event has established a platform for intensive networking between neuro-oncologists, neurosurgeons, neuroscientists, members of the biotechnology and pharmaceutical communities, members of the financial community and leaders of non-profit organizations. This year's summit highlighted dendritic cell vaccines, novel antibody, heat shock protein and targeted therapies as well as exosome technologies, MRI-guided therapies and other novel drug delivery tools. This report presents a short overview of the current progress in brain tumor research and therapy as presented at the 2013 Brain Tumor Biotech Summit.

sCO2 Power Cycles Summit Summary November 2017.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendez Cruz, Carmen Margarita; Rochau, Gary E.; Lance, Blake

Over the past ten years, the Department of Energy (DOE) has helped to develop components and technologies for the Supercritical Carbon Dioxide (sCO2) power cycle capable of efficient operation at high temperatures and high efficiency. The DOE Offices of Fossil Energy, Nuclear Energy, and Energy Efficiency and Renewable Energy collaborated in the planning and execution of the sCO2 Power Cycle Summit conducted in Albuquerque, NM in November 2017. The summit brought together participants from government, national laboratories, research, and industry to engage in discussions regarding the future of sCO 2 Power Cycles Technology. This report summarizes the work involved inmore » summit planning and execution, before, during, and after the event, including the coordination between three DOE offices and technical content presented at the event.« less

STL-based Analysis of TRAIL-induced Apoptosis Challenges the Notion of Type I/Type II Cell Line Classification

PubMed Central

Bertaux, François; Maler, Oded; Batt, Gregory

2013-01-01

Extrinsic apoptosis is a programmed cell death triggered by external ligands, such as the TNF-related apoptosis inducing ligand (TRAIL). Depending on the cell line, the specific molecular mechanisms leading to cell death may significantly differ. Precise characterization of these differences is crucial for understanding and exploiting extrinsic apoptosis. Cells show distinct behaviors on several aspects of apoptosis, including (i) the relative order of caspases activation, (ii) the necessity of mitochondria outer membrane permeabilization (MOMP) for effector caspase activation, and (iii) the survival of cell lines overexpressing Bcl2. These differences are attributed to the activation of one of two pathways, leading to classification of cell lines into two groups: type I and type II. In this work we challenge this type I/type II cell line classification. We encode the three aforementioned distinguishing behaviors in a formal language, called signal temporal logic (STL), and use it to extensively test the validity of a previously-proposed model of TRAIL-induced apoptosis with respect to experimental observations made on different cell lines. After having solved a few inconsistencies using STL-guided parameter search, we show that these three criteria do not define consistent cell line classifications in type I or type II, and suggest mutants that are predicted to exhibit ambivalent behaviors. In particular, this finding sheds light on the role of a feedback loop between caspases, and reconciliates two apparently-conflicting views regarding the importance of either upstream or downstream processes for cell-type determination. More generally, our work suggests that these three distinguishing behaviors should be merely considered as type I/II features rather than cell-type defining criteria. On the methodological side, this work illustrates the biological relevance of STL-diagrams, STL population data, and STL-guided parameter search implemented in the tool Breach. Such tools are well-adapted to the ever-increasing availability of heterogeneous knowledge on complex signal transduction pathways. PMID:23675292

Controls on lava lake level at Halema`uma`u Crater, Kilauea Volcano

NASA Astrophysics Data System (ADS)

Patrick, M. R.; Orr, T. R.

2013-12-01

Lava level is a fundamental measure of lava lake activity, but very little continuous long-term data exist worldwide to explore this aspect of lava lake behavior. The ongoing summit eruption at Kilauea Volcano began in 2008 and is characterized by an active lava lake within the eruptive vent. Lava level has been measured nearly continuously at Kilauea for several years using a combination of webcam images, laser rangefinder, and terrestrial LIDAR. Fluctuations in lava level have been a common aspect of the eruption and occur over several timescales. At the shortest timescale, the lava lake level can change over seconds to hours owing to two observed shallow gas-related processes. First, gas pistoning is common and is driven by episodic gas accumulation and release from the surface of the lava lake, causing the lava level to rise and fall by up to 20 m. Second, rockfalls into the lake trigger abrupt gas release, and lava level may drop as much as 10 m as a result. Over days, cyclic changes in lava level closely track cycles of deflation-inflation (DI) deformation events at the summit, leading to level changes up to 50 m. Rift zone intrusions have caused large (up to 140 m) drops in lava level over several days. On the timescale of weeks to months, the lava level follows the long-term inflation and deflation of the summit region, resulting in level changes up to 140 m. The remarkable correlation between lava level and deflation-inflation cycles, as well as the long-term deformation of the summit region, indicates that the lava lake acts as a reliable 'piezometer' (a measure of liquid pressure in the magma plumbing system); therefore, assessments of summit pressurization (and rift zone eruption potential) can now be carried out with the naked eye. The summit lava lake level is closely mirrored by the lava level within Pu`u `O`o crater, the vent area for the 30-year-long eruption on Kilauea's east rift zone, which is 20 km downrift of the summit. The coupling of these lava levels implies an efficient hydraulic connection between the summit and east rift zone vents. This connection has been indicated previously with geophysical data and is reinforced in a new quantitative manner with lava level data. Lastly, the current lava level at the summit is significantly lower than the mean level measured in the crater during continuous lava lake activity in the early 1900s. This is probably because the ongoing eruption at Pu`u `O`o 'taps' the magma supplied to the summit reservoir. Should the Pu`u `O`o eruption stop, the lava level at the summit would certainly rise in response. The precise correspondence between lava lake level and deformation of the summit implies that the lake level is a good indication of the pressure state of the magma reservoir. Tracking lava level over time may therefore provide an indication of the potential for future changes in eruptive activity. Such an observation has clear relevance for monitoring analogous open-vent basaltic volcanoes, especially where other measures of volcanic activity, like seismic or deformation measurements, may be lacking.

Monitoring of stage and velocity, for computation of discharge in the Summit Conduit near Summit, Illinois, 2010-2012

USGS Publications Warehouse

Johnson, Kevin K.; Goodwin, Greg E.

2013-01-01

Lake Michigan diversion accounting is the process used by the U. S. Army Corps of Engineers to quantify the amount of water that is diverted from the Lake Michigan watershed into the Illinois and Mississippi River Basins. A network of streamgages within the Chicago area waterway system monitor tributary river flows and the major river flow on the Chicago Sanitary and Ship Canal near Lemont as one of the instrumental tools used for Lake Michigan diversion accounting. The mean annual discharges recorded by these streamgages are used as additions or deductions to the mean annual discharge recorded by the main stream gaging station currently used in the Lake Michigan diversion accounting process, which is the Chicago Sanitary and Ship Canal near Lemont, Illinois (station number 05536890). A new stream gaging station, Summit Conduit near Summit, Illinois (station number 414757087490401), was installed on September 23, 2010, for the purpose of monitoring stage, velocity, and discharge through the Summit Conduit for the U.S. Army Corps of Engineers in accordance with Lake Michigan diversion accounting. Summit Conduit conveys flow from a small part of the lower Des Plaines River watershed underneath the Des Plaines River directly into the Chicago Sanitary and Ship Canal. Because the Summit Conduit discharges into the Chicago Sanitary and Ship Canal upstream from the stream gaging station at Lemont, Illinois, but does not contain flow diverted from the Lake Michigan watershed, it is considered a flow deduction to the discharge measured by the Lemont stream gaging station in the Lake Michigan diversion accounting process. This report offers a technical summary of the techniques and methods used for the collection and computation of the stage, velocity, and discharge data at the Summit Conduit near Summit, Illinois stream gaging station for the 2011 and 2012 Water Years. The stream gaging station Summit Conduit near Summit, Illinois (station number 414757087490401) is an example of a nonstandard stream gage. Traditional methods of equating stage to discharge historically were not effective. Examples of the nonstandard conditions include the converging tributary flows directly upstream of the gage; the trash rack and walkway near the opening of the conduit introducing turbulence and occasionally entraining air bubbles into the flow; debris within the conduit creating conditions of variable backwater and the constant influx of smaller debris that escapes the trash rack and catches or settles in the conduit and on the equipment. An acoustic Doppler velocity meter was installed to measure stage and velocity to compute discharge. The stage is used to calculate area based the stage-area rating. The index-velocity from the acoustic Doppler velocity meter is applied to the velocity-velocity rating and the product of the two rated values is a rated discharge by the index-velocity method. Nonstandard site conditions prevalent at the Summit Conduit stream gaging station generally are overcome through the index-velocity method. Despite the difficulties in gaging and measurements, improvements continue to be made in data collection, transmission, and measurements. Efforts to improve the site and to improve the ratings continue to improve the quality and quantity of the data available for Lake Michigan diversion accounting.

77 FR 25910 - National Trails System Act and Railroad Rights-of-Way

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

...] National Trails System Act and Railroad Rights-of-Way AGENCY: Surface Transportation Board, DOT. ACTION...) for rail banking and interim trail use under the National Trails System Act (Trails Act). New rules are adopted that require the parties jointly to notify the Board when an interim trail use/rail...

Thigmotaxis Mediates Trail Odour Disruption.

PubMed

Stringer, Lloyd D; Corn, Joshua E; Sik Roh, Hyun; Jiménez-Pérez, Alfredo; Manning, Lee-Anne M; Harper, Aimee R; Suckling, David M

2017-05-10

Disruption of foraging using oversupply of ant trail pheromones is a novel pest management application under investigation. It presents an opportunity to investigate the interaction of sensory modalities by removal of one of the modes. Superficially similar to sex pheromone-based mating disruption in moths, ant trail pheromone disruption lacks an equivalent mechanistic understanding of how the ants respond to an oversupply of their trail pheromone. Since significant compromise of one sensory modality essential for trail following (chemotaxis) has been demonstrated, we hypothesised that other sensory modalities such as thigmotaxis could act to reduce the impact on olfactory disruption of foraging behaviour. To test this, we provided a physical stimulus of thread to aid trailing by Argentine ants otherwise under disruptive pheromone concentrations. Trail following success was higher using a physical cue. While trail integrity reduced under continuous over-supply of trail pheromone delivered directly on the thread, provision of a physical cue in the form of thread slightly improved trail following and mediated trail disruption from high concentrations upwind. Our results indicate that ants are able to use physical structures to reduce but not eliminate the effects of trail pheromone disruption.

Prey-tracking behavior in the invasive terrestrial planarian Platydemus manokwari (Platyhelminthes, Tricladida)

NASA Astrophysics Data System (ADS)

Iwai, Noriko; Sugiura, Shinji; Chiba, Satoshi

2010-11-01

Platydemus manokwari is a broadly distributed invasive terrestrial flatworm that preys heavily on land snails and has been credited with the demise of numerous threatened island faunas. We examined whether P. manokwari tracks the mucus trails of land snail prey, investigated its ability to determine trail direction, and evaluated prey preference among various land snail species. A plastic treatment plate with the mucus trail of a single species and a control plate without the trail were placed side by side at the exit of cages housing P. manokwari. All trials were then videotaped overnight. The flatworms moved along plates with mucus trails, but did not respond to plates without trails, blank control (distilled water), or with conspecific flatworm trails. When presented at the midpoint of a snail mucus trail, the flatworms followed the trail in a random direction. The flatworms showed a preference when choosing between two plates, each with a mucus trail of different land snail species. Our results suggest that P. manokwari follows snail mucus trails based on chemical cues to increase the chance of encountering prey; however, trail-tracking behavior showed no directionality.

A Foamy Lava Lake at Kilauea Volcano, Hawai`i

NASA Astrophysics Data System (ADS)

Poland, M. P.; Carbone, D.

2012-12-01

Kilauea Volcano, in Hawai`i, is currently erupting from two locations simultaneously: along the east rift zone and at the summit. The east rift zone eruption began in 1983 and is characterized by lava effusion from the Pu`u `O`o and nearby vents, while the summit eruptive vent, which opened in 2008, persistently emits gas and small amounts of ash while hosting a lava lake. On March 5, 2011, a dike initiated from the east rift zone magma conduit and reached the surface, resulting in the 4.5-day-long Kamoamoa fissure eruption just uprift of Pu`u `O`o. The eruption was accompanied by summit deflation as magma withdrew from subsurface reservoirs to feed the fissure eruption. The level of the summit lava lake dropped as the summit deflated. A continuously recording gravimeter located at Kilauea's summit (about 150 m east of the center of the summit eruptive vent, 80 m above the vent rim, and about 140 m above the highest level reached by the lava lake) measured a gravity decrease of about 150 μGal during the lava level drop, after taking into account corrections for the solid Earth tide. The gravity signal is caused by a combination of three processes. First, subsidence of 15 cm due to summit deflation moved the gravimeter closer to the center of the Earth, resulting in a gravity increase. Second, mass removal from the subsurface magma reservoir at a depth of 1.4 km (based on a model from GPS and InSAR data) caused a gravity decrease. Third, the drop in the level of the lava lake, which reached a maximum of about 150 m, led to a gravity decrease. Assuming a simple point source of pressure change and a typical density for basaltic magma (2.3-2.7 g/cm3), the first two processes can only explain a small percent of the observed gravity decrease, which must therefore be mainly due to the drop in the level of the lava lake. We developed a numerical model of the summit eruptive vent that takes into account its complex geometry (as deduced from geological observations). Using the change in lava level over time (data courtesy of Matt Patrick), we estimated that a lava density of about 0.8 g/cm3 is required to fit the gravity time series. Gravity results, therefore, argue that the upper part of the vent is occupied by a low-density lava foam (in agreement with models of Kilauea's summit eruption from seismic, gas, and geologic data by Tim Orr and Matt Patrick) and provide the only means of quantifying the lava lake density.

The science of trail surveys: Recreation ecology provides new tools for managing wilderness trails

USGS Publications Warehouse

Marion, Jeffrey L.; Wimpey, Jeremy F.; Park, Logan O.

2011-01-01

Recreation ecology examines the effects of recreation on protected area ecosystems. One core focus of recreation ecology research is trail science, including the development of efficient protocols to assess and monitor the type and severity of resource impacts, analyses to improve knowledge of factors that influence trail conditions, and studies to assist land managers in improving trail design, maintenance, and visitor management. This article reviews alternative trail survey methodologies most useful for the management of wilderness and backcountry trail networks. Illustrations and implications from survey data for trail planning, design, and management are included.

Trail following and recruitment: Response of eastern tent caterpillarMalacosoma americanum to 5β-cholestane-3,24-dione and 5β-cholestan-3-one.

PubMed

Fitzgerald, T D

1993-03-01

Studies were conducted to determine the relative effectiveness of 5β-cholestane-3,24-dione (diketone) and 5β-cholestan-3-one (monoketone) in eliciting trail following from eastern tent caterpillars,Malacosoma americanum. In Y maze tests, trails prepared from the monoketone were followed preferentially over diketone trails, even when the diketone trail was several orders of magnitude stronger. Under field conditions, colonies readily abandoned well-developed trail systems in favor of artificial trails that were established with the monoketone. Other tests in which the caterpillars selected trails prepared from the monoketone (but not the diketone) more often than their own recruitment trails indicate that the monoketone constitutes the chemical basis of recruitment communication in this insect. The study also shows that tent caterpillars are highly sensitive to small differences in the amount of monoketone in a trail and can distinguish between new and aged trails prepared from the compound.

Chemical trail marking and following by caterpillars ofMalacosoma neustria.

PubMed

Peterson, S C

1988-03-01

Chemical trail marking and following by gregarious caterpillars,Malacosoma neustria L. (Lepidoptera: Lasiocampidae), was studied in the laboratory. As in other species ofMalacosoma, larvae deposit a trail pheromone from a sternal secretory site when searching the host for food. Larvae in the vanguard of foraging columns establish chemical trails as they explore new territory. Marking behavior diminishes as successive unfed foragers utilize the trail. These exploratory trails are subsequently overmarked by fed larvae returning to the tent. Other foragers follow the trails of fed larvae in preference to trails of unfed larvae. Thus, like the eastern tent caterpillar,M. americanum, successful foragers ofM. neustria recruit colony-mates to feeding sites. The chemical activity of both recruitment and exploratory trails degrades slowly, suggesting that the trail pheromone ofM. neustria is a nonvolatile substance. Caterpillars ofM. neustria readily follow the nonvolatile trail pheromone which has been identified fromM. americanum, 5β-cholestane-3,24-dione.

Accurate Natural Trail Detection Using a Combination of a Deep Neural Network and Dynamic Programming.

PubMed

Adhikari, Shyam Prasad; Yang, Changju; Slot, Krzysztof; Kim, Hyongsuk

2018-01-10

This paper presents a vision sensor-based solution to the challenging problem of detecting and following trails in highly unstructured natural environments like forests, rural areas and mountains, using a combination of a deep neural network and dynamic programming. The deep neural network (DNN) concept has recently emerged as a very effective tool for processing vision sensor signals. A patch-based DNN is trained with supervised data to classify fixed-size image patches into "trail" and "non-trail" categories, and reshaped to a fully convolutional architecture to produce trail segmentation map for arbitrary-sized input images. As trail and non-trail patches do not exhibit clearly defined shapes or forms, the patch-based classifier is prone to misclassification, and produces sub-optimal trail segmentation maps. Dynamic programming is introduced to find an optimal trail on the sub-optimal DNN output map. Experimental results showing accurate trail detection for real-world trail datasets captured with a head mounted vision system are presented.

A Return To Europe: Poland And Western Security Structures Since 1991

DTIC Science & Technology

2015-02-26

allow it to possibly mediate the conflict between the EU and the Arab world. Third, Poland’s military was stretched thin and over-exerted after a...came a historic Anglo -French summit in St. Malo in December 1998. At this summit, Great Britain changed its position on European security and defense...and defense developed slowly in the EU, not gaining much traction until 1998 during the historic Anglo -French summit in St. Malo. By the time Poland

Zimbabwe: 2008 Elections and Implications for U.S. Policy

DTIC Science & Technology

2008-09-26

region.඀ President Mwanawasa reportedly suffered a stroke on the eve of the AU Summit in Sharm el- Sheikh and passed away on August 19, 2008. Since...stakeholders once the results are announced.59 At the June 29- July 1 AU Summit in Sharm el Sheikh, Egypt, Botswana’s Vice President joined leaders from...Zimbabwe, and he called on AU leaders not to allow Mugabe to attend the Sharm el-Sheikh summit. The African Union has some precedent for intervening

RE-INTERPRETATION OF SUPRA-ARCADE DOWNFLOWS IN SOLAR FLARES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Savage, Sabrina L.; McKenzie, David E.; Reeves, Katharine K.

Following the eruption of a filament from a flaring active region, sunward-flowing voids are often seen above developing post-eruption arcades. First discovered using the soft X-ray telescope aboard Yohkoh, these supra-arcade downflows (SADs) are now an expected observation of extreme ultra-violet and soft X-ray coronal imagers and spectrographs (e.g, TRACE, SOHO/SUMER, Hinode/XRT, SDO/AIA). Observations made prior to the operation of AIA suggested that these plasma voids (which are seen in contrast to bright, high-temperature plasma associated with current sheets) are the cross-sections of evacuated flux tubes retracting from reconnection sites high in the corona. The high temperature imaging afforded bymore » AIA's 131, 94, and 193 Angstrom-Sign channels coupled with the fast temporal cadence allows for unprecedented scrutiny of the voids. For a flare occurring on 2011 October 22, we provide evidence suggesting that SADs, instead of being the cross-sections of relatively large, evacuated flux tubes, are actually wakes (i.e., trailing regions of low density) created by the retraction of much thinner tubes. This re-interpretation is a significant shift in the fundamental understanding of SADs, as the features once thought to be identifiable as the shrinking loops themselves now appear to be 'side effects' of the passage of the loops through the supra-arcade plasma. In light of the fact that previous measurements have attributed to the shrinking loops characteristics that may instead belong to their wakes, we discuss the implications of this new interpretation on previous parameter estimations and on reconnection theory.« less

Trails research: where do we go from here?

Treesearch

Michael A. Schuett; Patricia Seiser

2002-01-01

This paper describes a recent study focusing on trails research needs. This study was supported by American Trails. Using a Delphi technique, 86 trails experts representing a variety of federal, state and local agencies, nonprofits, and trail uses were queried by email on trails research needs. A Delphi technique is a prognostic tool for dealing with complex problems...

Ecological criteria, participant preferences and location models: A GIS approach toward ATV trail planning

Treesearch

Stephanie A. Snyder; Jay H. Whitmore; Ingrid E. Schneider; Dennis R. Becker

2008-01-01

This paper presents a geographic information system (GIS)-based method for recreational trail location for all-terrain vehicles (ATVs) which considers environmental factors, as well as rider preferences for trail attributes. The method utilizes the Least-Cost Path algorithm within a GIS framework to optimize trail location. The trail location algorithm considered trail...

Estimating soil erosion on hiking trails in the Sierra Mariola Natural Park in southern Spain

NASA Astrophysics Data System (ADS)

Magdalena Warter, Maria; Peeters, Mattias; Kuppen, Emiel; Blok, Kas; Dilly, Lina

2017-04-01

Natural parks and protected natural areas provide excellent recreational opportunities for outdoor activities through the richness of the natural environment and the abundance of walking trails. Hiking, mountain biking and running have rapidly gained popularity over recent years increasing concerns about the erosion and degradation of hiking trails caused by (over)use. This is also the case in the Sierra Mariola Natural Park in southeast Spain, which is a popular destination for tourists due to its diverse fauna and flora. The increasing number of tourists together with the negative impacts of climate change necessitates a better understanding of the key soil erosion processes impacting hiking trails. There are 4 scenic trail routes in the Natural Park amounting to 21 km plus an additional network of unofficial trails. Apart from the heavy touristic traffic on the trails there are large trail running events with up to 1000 participants becoming increasingly popular, however local park authorities have voiced concerns about the impacts of these activities on the trails. Despite the popularity of walking trails around the world, there is a paucity of research exploring soil erosion from these features. Therefore, the aims of this study are: 1) to ascertain the amount of erosion that occurs on trails in the Sierra Mariola Natural Park, and 2) determine the key factors that influence soil erosion. Some 100 km of trails were evaluated (both official and unmarked trails), with route segments ranging between 2 and 10 km. A trail classification system was developed to group trail segments based on their surface characteristics (bedrock, gravel, mixed sediment, soil or man-made) and specific erosion features (rills, ditch-shaped, tilted). For each class, the average erosion rate was calculated which ranged from 262 t/ha for soil-based trails to 2006 t/ha for heavily eroded, ditch-shaped trails. The spatial distribution of the different erosion rates and trail types were mapped using ArcGIS to provide an overview of the most affected areas. A DEM model of the park was also used to assess the relative influence on erosion of various factors such as slope, geology, aspect and elevation. Slope, aspect, vegetation and geology are the key variables influencing the erosion rate of trails. Also, the amount and type of trail use also influence trail erosion. Further studies are recommended to explore the carrying capacity and threshold limits of trails.

Port Stakeholder Summit: Advancing More Sustainable Ports (April 2014)

EPA Pesticide Factsheets

EPA's National Port Stakeholders Summit, Advancing More Sustainable Ports, focused on actions to protect air quality while reducing climate risk and supporting economic growth, making ports more environmentally sustainable.

Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells.

PubMed

Xu, Ying; Gao, Cheng-Cheng; Pan, Zhen-Guo; Zhou, Chuan-Wen

2018-02-12

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promising value for cancer therapy due to its capacity to induce apoptosis in cancer cells. Nevertheless, TRAIL therapy is greatly hampered by its resistance. Irigenin (Iri), isoflavonoids, can be isolated from the rhizome of Belamcanda chinensis, and has been shown anti-cancer properties. In this study, we explored if Iri could enhance TRAIL-regulated apoptosis in TRAIL resistant gastric cancer cells. Iri significantly potentiated TRAIL-triggered cytotoxicity. Iri alone and TRAIL alone showed no effective role in apoptosis induction, whereas combined treatment with Iri and TRAIL markedly induced apoptosis in cancer cells, as evidenced by the up-regulation of cleaved Caspase-8/-9/-3 and PARP. Additionally, the sensitization to TRAIL was along with the enhancement of pro-apoptotic proteins, including FAS-associated protein with death domain (FADD), death receptor 5 (DR5) and Bax. And suppressing FADD, DR5 and Bax by si RNA significantly reduced the apoptosis and enhanced the cell viability induced by the co-application of Iri and TRAIL. Moreover, the sensitization to TRAIL was accompanied by the decrease of Cellular-FLICE inhibitory protein (c-FLIP), Bcl-2 and Survivin. Additionally, Iri could sensitize TRAIL to produce reactive oxygen species (ROS). Pre-treatment of N-acetyl-cysteine (NAC), ROS scavenger, attenuated Iri plus TRAIL-induced apoptosis and improved cell viability. Finally, combination of Iri and TRAIL inhibited tumor growth in the xenograft model. Collectively, our present study gave new insights into the effects of Iri on potentiating TRAIL-sensitivity, and suggested that Iri could be a potential candidate for sensitizer of TRAIL-resistant cancer cell treatment. Copyright © 2018. Published by Elsevier Inc.

Is Kīlauea's East Rift Zone eruption running out of gas?

NASA Astrophysics Data System (ADS)

Sutton, A. J.; Elias, T.; Orr, T. R.; Patrick, M. R.; Poland, M. P.; Thornber, C. R.

2015-12-01

Gases exsolving from magma are a key force that drives eruptive activity, and emissions from Kīlauea's East Rift Zone (ERZ) dominated the volcano's gas release from the beginning of the long-running and voluminous Pu'u 'Ō'ō eruption in 1983, through February 2008. In the months prior to the March 2008 onset of eruptive activity within Halema'uma'u Crater, however, SO2 degassing at the summit climbed substantially, and summit gas release has remained elevated since. These unprecedented emissions associated with the new summit eruption effectively began robbing gas from magma destined for Kīlauea's ERZ. As a result, ERZ SO2discharge, which had averaged 1,700 +-380 t/d for the previous 15 years, declined sharply and steadily beginning in September, 2008, and reached a new steady low of 380 +- 100 t/d by early 2011. This level persisted through mid-2015. In the years since the late 2008 downturn in ERZ SO2 emissions, there has been an overall slowdown in ERZ eruptive activity. Elevated emissions and effusive activity occurred briefly during the 2011 Kamoamoa fissure eruption and two other outbreaks at Pu'u 'Ō'ō , but otherwise ERZ eruptive activity had waned by 2010, when effusion rates were measured at about half of the long-term rate. Also, the sulfur preserved in ERZ olivine melt-inclusions, which provides a record of pre-eruptive SO2degassing, has steadily declined along with equilibration temperatures of host olivine phenocrysts, since 2008. We suggest that the drop in gas content of magma reaching the ERZ, owing to summit pre-eruptive degassing, has contributed significantly to the downturn in ERZ activity. While SO2 emissions from the ERZ have dropped to sustained levels lower than anything seen in the past 20 years, summit emissions have remained some of the highest recorded since regular measurements began at Kīlauea in 1979. Overall, average total SO2 discharge from Kīlauea in 2014, summit and ERZ, is still about 50% higher than for the 15 years prior to 2008. The effects of summit pre-eruptive degassing observed at Kilauea may have application at other summit-rift shield volcanoes.

Recent uplift and hydrothermal activity at Tangkuban Parahu volcano, west Java, Indonesia

USGS Publications Warehouse

Dvorak, J.; Matahelumual, J.; Okamura, A.T.; Said, H.; Casadevall, T.J.; Mulyadi, D.

1990-01-01

Tangkuban Parahu is an active stratovolcano located 17 km north of the city of Bandung in the province west Java, Indonesia. All historical eruptive activity at this volcano has been confined to a complex of explosive summit craters. About a dozen eruptions-mostly phreatic events- and 15 other periods of unrest, indicated by earthquakes or increased thermal activity, have been noted since 1829. The last magmatic eruption occurred in 1910. In late 1983, several small phreatic explosions originated from one of the summit craters. More recently, increased hydrothermal and earthquake activity occurred from late 1985 through 1986. Tilt measurements, using a spirit-level technique, have been made every few months since February 1981 in the summit region and along the south and east flanks of the volcano. Measurements made in the summit region indicated uplift since the start of these measurements through at least 1986. From 1981 to 1983, the average tilt rate at the edges of the summit craters was 40-50 microradians per year. After the 1983 phreatic activity, the tilt rate decreased by about a factor of five. Trilateration surveys across the summit craters and on the east flank of the volcano were conducted in 1983 and 1986. Most line length changes measured during this three-year period did not exceed the expected uncertainty of the technique (4 ppm). The lack of measurable horizontal strain across the summit craters seems to contradict the several years of tilt measurements. Using a point source of dilation in an elastic half-space to model tilt measurements, the pressure center at Tangkuban Parahu is located about 1.5 km beneath the southern part of the summit craters. This is beneath the epicentral area of an earthquake swarm that occurred in late 1983. The average rate in the volume of uplift from 1981 to 1983 was 3 million m3 per year; from 1983 to 1986 it averaged about 0.4 million m3 per year. Possible causes for this uplift are increased pressure within a very shallow magma body or heating and expansion of a confined aquifier. ?? 1990 Springer-Verlag.

Awareness and use of community walking trails.

PubMed

Reed, Julian A; Ainsworth, Barbara E; Wilson, Dawn K; Mixon, Gary; Cook, Annette

2004-11-01

Community trail development is an emerging strategy to increase physical activity (PA) among community residents. The purpose of this study was to assess awareness and use of trails and compare perceptions to objective data. A telephone survey was administered to a stratified sample of adults (N = 1,112) in a southeastern county in the United States. Respondents' home addresses and the locations of trails were entered into a GIS database. A kappa statistic was used to measure agreement between awareness and presence of trails. Differences in reported trail use patterns by sex, race, education, and PA levels were evaluated. There was no agreement between the awareness and presence of trails (kappa = 0.07). Fifty-six percent of the respondents reported having trails; however, only 33% reported using the trails. Of the trail users, 42% reported being regularly active in moderate-to-vigorous PA (30+ min/day for 5+ days/week), and 51% reported being less active (P < 0.003). Among walkers (> or =30 min/day for > or =5 days/week), 49% of regular walkers and 35% of irregular walkers (< walkers) reported using the trails (P < 0.04). Awareness of existing trails in this community and levels of use were low. Marketing programs should promote awareness and use of trails among older adults and irregularly active adults.

The association of trail use with weather-related factors on an urban greenway.

PubMed

Burchfield, Ryan A; Fitzhugh, Eugene C; Bassett, David R

2012-02-01

To study the association between weather-related measures and objectively measured trail use across 3 seasons. Weather has been reported as a barrier to outdoor physical activity (PA), but previous studies have explained only a small amount of the variance in PA using weather-related measures. The dependent variable of this study was trail use measured as mean hourly trail counts by an infrared trail counter located on a greenway. Each trail count represents 1 person breaking the infrared beam of the trail counter. Two sources of weather-related measures were obtained by a site-specific weather station and a public domain weather source. Temperature, relative humidity, and precipitation were significantly correlated with trail counts recorded during daylight hours. More precise hourly weather-related measures explained 42% of the variance in trail counts, regardless of the weather data source with temperature alone explaining 18% of the variance in trail counts. After controlling for all seasonal and weekly factors, every 1°F increase in temperature was associated with an increase of 1.1 trail counts/hr up to 76°F, at which point trail use began to slightly decrease. Weather-related factors have a moderate association with trail use along an urban greenway.

A spatial exploration of informal trail networks within Great Falls Park, VA

USGS Publications Warehouse

Wimpey, Jeremy; Marion, Jeffrey L.

2011-01-01

Informal (visitor-created) trails represent a threat to the natural resources of protected natural areas around the globe. These trails can remove vegetation, displace wildlife, alter hydrology, alter habitat, spread invasive species, and fragment landscapes. This study examines informal and formal trails within Great Falls Park, VA, a sub-unit of the George Washington Memorial Parkway, managed by the U.S. National Park Service. This study sought to answer three specific questions: 1) Are the physical characteristics and topographic alignments of informal trails significantly different from formal trails, 2) Can landscape fragmentation metrics be used to summarize the relative impacts of formal and informal trail networks on a protected natural area? and 3) What can we learn from examining the spatial distribution of the informal trails within protected natural areas? Statistical comparisons between formal and informal trails in this park indicate that informal trails have less sustainable topographic alignments than their formal counterparts. Spatial summaries of the lineal and areal extent and fragmentation associated with the trail networks by park management zones compare park management goals to the assessed attributes. Hot spot analyses highlight areas of high trail density within the park and findings provide insights regarding potential causes for development of dense informal trail networks.

Certification trails for data structures

NASA Technical Reports Server (NTRS)

Sullivan, Gregory F.; Masson, Gerald M.

1993-01-01

Certification trails are a recently introduced and promising approach to fault detection and fault tolerance. The applicability of the certification trail technique is significantly generalized. Previously, certification trails had to be customized to each algorithm application; trails appropriate to wide classes of algorithms were developed. These certification trails are based on common data-structure operations such as those carried out using these sets of operations such as those carried out using balanced binary trees and heaps. Any algorithms using these sets of operations can therefore employ the certification trail method to achieve software fault tolerance. To exemplify the scope of the generalization of the certification trail technique provided, constructions of trails for abstract data types such as priority queues and union-find structures are given. These trails are applicable to any data-structure implementation of the abstract data type. It is also shown that these ideals lead naturally to monitors for data-structure operations.

Happy trails: the effect of a media campaign on urban trail use in southern Nevada.

PubMed

Clark, Sheila; Bungum, Tim J; Meacham, Mindy; Coker, Lisa

2015-01-01

Many Americans do not meet recommendations for physical activity (PA). Communities are building trail networks to encourage PA, but the relationship between trails and PA is not well understood. We monitored usage of urban trails (N = 10) in Las Vegas, NV, before and after a promotional marketing campaign (October 2011 and April 2012). The media campaign featured print, online, and radio ads, as well as billboards and signage on gas pumps. Data were collected with infrared monitors that were placed on the trails for periods of 7 days. We compared preintervention and postintervention usage rates. Mean usage increased (P < .001) from 3.91 to 5.95 users per hour (52.17%) after the promotional campaign. We observed significant increases at 7 individual trails, significant declines at 2 trails, and no change at 1 trail. Promotional campaigns may be an effective way to increase trail usage and encourage PA.

Trail-following in termites: Evidence for a multicomponent system.

PubMed

Kaib, M; Bruinsma, O; Leuthold, R H

1982-09-01

Several African termite species from different subfamilies and different habitats are sensitive to trail-active extracts or to naturally laid trails from other species. Using single-extract bioassays, it is shown that the response threshold for trail-following is nearly identical for all tested species (except forHodotermes mossambicus). However, when termite workers have a choice between trails from their own species and from other species, conspecific trail-following is exclusively observed. This phenomenon can be counteracted by dilution (1∶10) of the conspecific trail-pheromone extract. Tests of the trail activity of various synthetic alcohols show that among these, the highest sensitivity of termite workers is to (Z)-3-dodecen-1-ol. Based on our experimental data, we postulate that, in addition to a generally active trail-pheromone constituent (an unsaturated primary C12 alcohol) or a pool of chemically closely related alcohols, other species-specific components are present in termite trails.

Indicators and protocols for monitoring impacts of formal and informal trails in protected areas

USGS Publications Warehouse

Marion, Jeffrey L.; Leung, Yu-Fai

2011-01-01

Trails are a common recreation infrastructure in protected areas and their conditions affect the quality of natural resources and visitor experiences. Various trail impact indicators and assessment protocols have been developed in support of monitoring programs, which are often used for management decision-making or as part of visitor capacity management frameworks. This paper reviews common indicators and assessment protocols for three types of trails, surfaced formal trails, unsurfaced formal trails, and informal (visitor-created) trails. Monitoring methods and selected data from three U.S. National Park Service units are presented to illustrate some common trail impact indicators and assessment options.

Metformin sensitizes triple-negative breast cancer to proapoptotic TRAIL receptor agonists by suppressing XIAP expression.

PubMed

Strekalova, Elena; Malin, Dmitry; Rajanala, Harisha; Cryns, Vincent L

2017-06-01

Despite robust antitumor activity in diverse preclinical models, TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists have not demonstrated efficacy in clinical trials, underscoring the need to identify agents that enhance their activity. We postulated that the metabolic stress induced by the diabetes drug metformin would sensitize breast cancer cells to TRAIL receptor agonists. Human triple (estrogen receptor, progesterone receptor, and HER2)-negative breast cancer (TNBC) cell lines were treated with TRAIL receptor agonists (monoclonal antibodies or TRAIL peptide), metformin, or the combination. The effects on cell survival, caspase activation, and expression of TRAIL receptors and the antiapoptotic protein XIAP were determined. In addition, XIAP was silenced by RNAi in TNBC cells and the effects on sensitivity to TRAIL were determined. The antitumor effects of metformin, TRAIL, or the combination were evaluated in an orthotopic model of metastatic TNBC. Metformin sensitized diverse TNBC cells to TRAIL receptor agonists. Metformin selectively enhanced the sensitivity of transformed breast epithelial cells to TRAIL receptor agonist-induced caspase activation and apoptosis with little effect on untransformed breast epithelial cells. These effects of metformin were accompanied by robust reductions in the protein levels of XIAP, a negative regulator of TRAIL-induced apoptosis. Silencing XIAP in TNBC cells mimicked the TRAIL-sensitizing effects of metformin. Metformin also enhanced the antitumor effects of TRAIL in a metastatic murine TNBC model. Our findings indicate that metformin enhances the activity of TRAIL receptor agonists, thereby supporting the rationale for additional translational studies combining these agents.

Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells.

PubMed

Yoon, Ji-Yong; Cho, Hyun-Soo; Lee, Jeong-Ju; Lee, Hyo-Jung; Jun, Soo Young; Lee, Jae-Hye; Song, Hyuk-Hwan; Choi, SangHo; Saloura, Vassiliki; Park, Choon Gil; Kim, Cheol-Hee; Kim, Nam-Soon

2016-04-01

TRAIL (TNF-related apoptosis inducing ligand) is a promising anti-cancer drug target that selectively induces apoptosis in cancer cells. However, many cancer cells are resistant to TRAIL-induced apoptosis. Therefore, reversing TRAIL resistance is an important step for the development of effective TRAIL-based anti-cancer therapies. We previously reported that knockdown of the TOR signaling pathway regulator-like (TIPRL) protein caused TRAIL-induced apoptosis by activation of the MKK7-c-Jun N-terminal Kinase (JNK) pathway through disruption of the MKK7-TIPRL interaction. Here, we identified Taraxacum officinale F.H. Wigg (TO) as a novel TRAIL sensitizer from a set of 500 natural products using an ELISA system and validated its activity by GST pull-down analysis. Furthermore, combination treatment of Huh7 cells with TRAIL and TO resulted in TRAIL-induced apoptosis mediated through inhibition of the MKK7-TIPRL interaction and subsequent activation of MKK7-JNK phosphorylation. Interestingly, HPLC analysis identified chicoric acid as a major component of the TO extract, and combination treatment with chicoric acid and TRAIL induced TRAIL-induced cell apoptosis via JNK activation due to inhibition of the MKK7-TIPRL interaction. Our results suggest that TO plays an important role in TRAIL-induced apoptosis, and further functional studies are warranted to confirm the importance of TO as a novel TRAIL sensitizer for cancer therapy. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

NASA Education Stakeholder's Summit

NASA Image and Video Library

2010-09-12

NASA Administrator Charles Bolden gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

2012 ARPA-E Energy Innovation Summit: Profiling General Compression: A River of Wind

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marcus, David; Ingersoll, Eric

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These 'performer videos' highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. General Compression,more » with the help of ARPA-E funding, has created an advanced air compression process which can store and release more than a weeks worth of the energy generated by wind turbines.« less

2012 ARPA-E Energy Innovation Summit: Profiling General Compression: A River of Wind

ScienceCinema

Marcus, David; Ingersoll, Eric

2018-05-30

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These 'performer videos' highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. General Compression, with the help of ARPA-E funding, has created an advanced air compression process which can store and release more than a weeks worth of the energy generated by wind turbines.

Estimating the economic value and impacts of recreational trails: a case study of the Virginia creeper rail trail

Treesearch

J. Michael Bowker; John C. Bergstrom; Joshua Gill

2007-01-01

Many communities are interested in developing and maintaining recreational trails to benefit trail users and as tourist attractions to stimulate economic growth. In this paper, a study is described which estimates the net economic value to trail users and the local economic impacts of the Virginia Creeper Rail Trail in south-western Virginia, USA. The monetary...

Trails at LANL - Public Meeting and Forum - July 26, 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pava, Daniel Seth

2016-07-26

These are the slides of a meeting about trails at Los Alamos National Laboratory. The meeting goals are the folllowing: to inform and educate citizens about LANL trails management issues that include resource protection, safety, security and trails etiquette; to explain how and why LANL trails can be closed and reopened; and to understand your concerns and ideas about LANL trails use.

A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance

PubMed Central

Dimberg, Lina Y.; Towers, Christina G.; Behbakht, Kian; Hotz, Taylor J.; Kim, Jihye; Fosmire, Susan; Porter, Christopher C.; Tan, Aik-Choon; Thorburn, Andrew; Ford, Heide L.

2017-01-01

TNF-related apoptosis inducing ligand (TRAIL) is a potent death-inducing ligand that mediates apoptosis through the extrinsic pathway and serves as an important endogenous tumor suppressor mechanism. Because tumor cells are often killed by TRAIL and normal cells are not, drugs that activate the TRAIL pathway have been thought to have potential clinical value. However, to date, most TRAIL-related clinical trials have largely failed due to the tumor cells having intrinsic or acquired resistance to TRAIL-induced apoptosis. Previous studies to identify resistance mechanisms have focused on targeted analysis of the canonical apoptosis pathway and other known regulators of TRAIL receptor signaling. To identify novel mechanisms of TRAIL resistance in an unbiased way, we performed a genome wide shRNA screen for genes that regulate TRAIL sensitivity in sub-lines that had been selected for acquired TRAIL resistance. This screen identified previously unknown mediators of TRAIL resistance including Angiotensin II Receptor 2, Crk-like protein, T-Box Transcription Factor 2 and solute carrier family 26 member 2 (SLC26A2). SLC26A2 downregulates the TRAIL receptors, DR4 and DR5, and this downregulation is associated with resistance to TRAIL. Its expression is high in numerous tumor types compared to normal cells, and in breast cancer, SLC26A2 is associated with a significant decrease in relapse free survival. PMID:28108622

The efficacy of combined educational and site management actions in reducing off-trail hiking in an urban-proximate protected area.

PubMed

Hockett, Karen S; Marion, Jeffrey L; Leung, Yu-Fai

2017-12-01

Park and protected area managers are tasked with protecting natural environments, a particularly daunting challenge in heavily visited urban-proximate areas where flora and fauna are already stressed by external threats. In this study, an adaptive management approach was taken to reduce extensive off-trail hiking along a popular trail through an ecologically diverse and significant area in the Chesapeake and Ohio National Historical Park near Washington DC. Substantial amounts of off-trail hiking there had created an extensive 16.1 km network of informal (visitor-created) trails on a 39 ha island in the Potomac Gorge. A research design with additive treatments integrating educational and site management actions was applied and evaluated using self-reported behavior from an on-site visitor survey and unobtrusive observations of off-trail hiking behavior at two locations along the trail. Study treatments included: 1) trailhead educational signs developed using attribution theory and injunctive-proscriptive wording, 2) symbolic "no hiking" prompter signs attached to logs placed across all informal trails, 3) placement of concealing leaf litter and small branches along initial sections of informal trails, 4) restoration work on selected trails with low fencing, and 5) contact with a trail steward to personally communicate the trailhead sign information. The final, most comprehensive treatment reduced visitor-reported intentional off-trail hiking from 70.3% to 43.0%. Direct observations documented reduction in off-trail hiking from 25.9% to 2.0%. The educational message and site management actions both contributed to the decline in off-trail travel and the two evaluation methods enhanced our ability to describe the efficacy of the different treatments in reducing off-trail travel. Published by Elsevier Ltd.

Validation of Walking Trails for the Urban Training™ of Chronic Obstructive Pulmonary Disease Patients.

PubMed

Arbillaga-Etxarri, Ane; Torrent-Pallicer, Jaume; Gimeno-Santos, Elena; Barberan-Garcia, Anael; Delgado, Anna; Balcells, Eva; Rodríguez, Diego A; Vilaró, Jordi; Vall-Casas, Pere; Irurtia, Alfredo; Rodriguez-Roisin, Robert; Garcia-Aymerich, Judith

2016-01-01

Accessible interventions to train patients with chronic obstructive pulmonary disease (COPD) are needed. We designed urban trails of different intensities (low, moderate and high) in different types of public spaces (boulevard, beach and park). We aimed to validate the trails' design by assessing the physiological response to unsupervised walking trails of: (1) different intensities in COPD patients, and (2) same intensity from different public spaces in healthy adults. On different days and under standardized conditions, 10 COPD patients walked the three intensity trails designed in a boulevard space, and 10 healthy subjects walked the three intensity trails in three different spaces. We measured physiological response and energy expenditure using a gas analyzer. We compared outcomes across trails intensity and/or spaces using mixed-effects linear regression. In COPD patients, physiological response and energy expenditure increased significantly according to the trails intensity: mean (SD) peak V̇O2 15.9 (3.5), 17.4 (4.7), and 17.7 (4.4) mL/min/kg (p-trend = 0.02), and MET-min 60 (23), 64 (26), 72 (31) (p-trend<0.01) in low, moderate and high intensity trails, respectively. In healthy subjects there were no differences in physiological response to walking trails of the same intensity across different spaces. We validated the trails design for the training of COPD patients by showing that the physiological response to and energy expenditure on unsupervised walking these trails increased according to the predefined trails' intensity and did not change across trails of the same intensity in different public space. Walkable public spaces allow the design of trails that could be used for the training of COPD patients in the community.

The efficacy of combined educational and site management actions in reducing off-trail hiking in an urban-proximate protected area

USGS Publications Warehouse

Hockett, Karen; Marion, Jeff; Leung, Yu-Fai

2017-01-01

Park and protected area managers are tasked with protecting natural environments, a particularly daunting challenge in heavily visited urban-proximate areas where flora and fauna are already stressed by external threats. In this study, an adaptive management approach was taken to reduce extensive off-trail hiking along a popular trail through an ecologically diverse and significant area in the Chesapeake and Ohio National Historical Park near Washington DC. Substantial amounts of off-trail hiking there had created an extensive 16.1 km network of informal (visitor-created) trails on a 39 ha island in the Potomac Gorge. A research design with additive treatments integrating educational and site management actions was applied and evaluated using self-reported behavior from an on-site visitor survey and unobtrusive observations of off-trail hiking behavior at two locations along the trail. Study treatments included: 1) trailhead educational signs developed using attribution theory and injunctive-proscriptive wording, 2) symbolic “no hiking” prompter signs attached to logs placed across all informal trails, 3) placement of concealing leaf litter and small branches along initial sections of informal trails, 4) restoration work on selected trails with low fencing, and 5) contact with a trail steward to personally communicate the trailhead sign information. The final, most comprehensive treatment reduced visitor-reported intentional off-trail hiking from 70.3% to 43.0%. Direct observations documented reduction in off-trail hiking from 25.9% to 2.0%. The educational message and site management actions both contributed to the decline in off-trail travel and the two evaluation methods enhanced our ability to describe the efficacy of the different treatments in reducing off-trail travel.

3-Bromopyruvate enhances TRAIL-induced apoptosis in human nasopharyngeal carcinoma cells through CHOP-dependent upregulation of TRAIL-R2.

PubMed

Can, Zhou; Lele, Song; Zhirui, Zhang; Qiong, Pan; Yuzhong, Chen; Lingling, Liu; Surong, Zhao; Yiming, Sun; Pei, Zhang; Chenchen, Jiang; Liu, Hao

2017-08-01

Past reports have shown that the sensitivity of cancer cells to TRAIL-induced apoptosis is related to their expression of TRAIL-death receptors on the cell surface. However, the level of TRAIL-death receptors expression on cancer cells is always low. Our previous research showed that nasopharyngeal carcinoma (NPC) cells have a poor sensitivity to low doses of TRAIL. Here, we evaluated combined treatment with the energy inhibitor 3-bromopyruvate (3BP) and TRAIL as a method to produce an increased apoptotic response in NPC cells. The results showed that 3BP and TRAIL together produced higher cytotoxicity and increased TRAIL-R2 expression in NPC cells compared with the effects of either 3BP or TRAIL alone. These findings led us to hypothesize that 3BP may sensitize NPC cells to TRAIL. 3BP is a metabolic blocker that inhibits hexokinase II activity, suppresses ATP production, and induces endoplasmic reticulum (ER) stress. Our results showed that 3BP also activated AMP-activated protein kinase, which we found to play an important role in the induction of ER stress by 3BP. Furthermore, the induction of TRAIL-R2 expression and the sensitization of the NPC cells to TRAIL by 3BP were reduced when we inhibited the expression of CHOP. Taken together, our results showed that a low dose of 3BP sensitized NPC cells to TRAIL-induced apoptosis by the upregulation of CHOP, which was mediated by the activation of AMP-activated protein kinase and ER stress. The results showed that 3BP is a promising candidate agent for enhancing the therapeutic response to TRAIL in NPC.

The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells.

PubMed

Azijli, Kaamar; van Roosmalen, Ingrid A M; Smit, Jorn; Pillai, Saravanan; Fukushima, Masakazu; de Jong, Steven; Peters, Godefridus J; Bijnsdorp, Irene V; Kruyt, Frank A E

2014-06-01

TRAIL, a tumor selective anticancer agent, may be used for the treatment of non-small cell lung cancer (NSCLC). However, TRAIL resistance is frequently encountered. Here, the combined use of TRAIL with trifluorothymidine (TFT), a thymidylate synthase inhibitor, was examined for sensitizing NSCLC cells to TRAIL. Interactions between TRAIL and TFT were studied in NSCLC cells using growth inhibition and apoptosis assays. Western blotting and flow cytometry were used to investigate underlying mechanisms. The combined treatment of TFT and TRAIL showed synergistic cytotoxicity in A549, H292, H322 and H460 cells. For synergistic activity, the sequence of administration was important; TFT treatment followed by TRAIL exposure did not show sensitization. Combined TFT and TRAIL treatment for 24 h followed by 48 h of TFT alone was synergistic in all cell lines, with combination index values below 0.9. The treatments affected cell cycle progression, with TRAIL inducing a G1 arrest and TFT, a G2/M arrest. TFT activated Chk2 and reduced Cdc25c levels known to cause G2/M arrest. TRAIL-induced caspase-dependent apoptosis was enhanced by TFT, whereas TFT alone mainly induced caspase-independent death. TFT increased the expression of p53 and p21/WAF1, and p53 was involved in the increase of TRAIL-R2 surface expression. TFT also caused downregulation of cFLIP and XIAP and increased Bax expression. TFT enhances TRAIL-induced apoptosis in NSCLC cells by sensitizing the apoptotic machinery at different levels in the TRAIL pathway. Our findings suggest a possible therapeutic benefit of the combined use of TFT and TRAIL in NSCLC.

A Summary of the American Society of Echocardiography Foundation Value-Based Healthcare: Summit 2014: The Role of Cardiovascular Ultrasound in the New Paradigm.

PubMed

Byrd, Benjamin F; Abraham, Theodore P; Buxton, Denis B; Coletta, Anthony V; Cooper, James H S; Douglas, Pamela S; Gillam, Linda D; Goldstein, Steven A; Graf, Thomas R; Horton, Kenneth D; Isenberg, Alexis A; Klein, Allan L; Kreeger, Joseph; Martin, Randolph P; Nedza, Susan M; Navathe, Amol; Pellikka, Patricia A; Picard, Michael H; Pilotte, John C; Ryan, Thomas J; Rychik, Jack; Sengupta, Partho P; Thomas, James D; Tucker, Leslie; Wallace, William; Ward, R Parker; Weissman, Neil J; Wiener, David H; Woodruff, Sarah

2015-07-01

Value-Based Healthcare: Summit 2014 clearly achieved the three goals set forth at the beginning of this document. First, the live event informed and educated attendees through a discussion of the evolving value-based healthcare environment, including a collaborative effort to define the important role of cardiovascular ultrasound in that environment. Second, publication of these Summit proceedings in the Journal of the American Society of Echocardiography will inform a wider audience of the important insights gathered. Third, moving forward, the ASE will continue to build a ‘‘living resource’’ on its website, http://www.asecho.org, for clinicians, researchers, and administrators to use in advocating for the value of cardiovascular ultrasound in the new value-based healthcare environment. The ASE looks forward to incorporating many of the Summit recommendations as it works with its members, legislators, payers, hospital administrators, and researchers to demonstrate and increase the value of cardiovascular ultrasound. All Summit attendees shared in the infectious enthusiasm generated by this proactive approach to ensuring cardiovascular ultrasound’s place as ‘‘The Value Choice’’ in cardiac imaging.

Communication strategies to help reduce the prevalence of non-communicable diseases: Proceedings from the inaugural IFIC Foundation Global Diet and Physical Activity Communications Summit

PubMed Central

Fernstrom, Madelyn H; Reed, Kimberly A; Rahavi, Elizabeth B; Dooher, Carrie C

2012-01-01

Non-communicable diseases (NCDs), which include cardiovascular disease, cancer, and diabetes, all of which are associated with the common risk factors of poor diet and insufficient physical activity, caused 63% of all deaths globally in 2008. The increasing discussion of global NCDs, including at the 2011 United Nations General Assembly High-level Meeting on the Prevention and Control of Non-communicable Diseases, and a request for multi-stakeholder engagement, prompted the International Food Information Council Foundation to sponsor the Global Diet and Physical Activity Communications Summit: “Insights to Motivate Healthful, Active Lifestyles” on September 19, 2011, in New York City. The Summit brought together a diverse group of stakeholders, representing 34 nations from governments; communication, health, nutrition, and fitness professions; civil society; nonprofits; academia; and the private sector. The Summit provided expert insights and best practices for the use of science-based, behavior-focused communications to motivate individuals to achieve healthful, active lifestyles, with the goal of reducing the prevalence of NCDs. Presented here are some of the highlights and key findings from the Summit. PMID:22537216

Computational fluid dynamic modeling of the summit of Mt. Hopkins for the MMT Observatory

NASA Astrophysics Data System (ADS)

Callahan, S.

2010-07-01

Over the past three decades, the staff of the MMT observatory used a variety of techniques to predict the summit wind characteristics including wind tunnel modeling and the release of smoke bombs. With the planned addition of a new instrument repair facility to be constructed on the summit of Mt. Hopkins, new computational fluid dynamic (CFD) models were made to determine the building's influence on the thermal environment around the telescope. The models compared the wind profiles and density contours above the telescope enclosure with and without the new building. The results show the steeply-sided Mount Hopkins dominates the summit wind profiles. In typical winds, the height of the telescope remains above the ground layer and is sufficiently separated from the new facility to insure the heat from the new building does not interfere with the telescope. The results also confirmed the observatories waste heat exhaust duct location needs to be relocated to prevent heat from being trapped in the wind shadow of the new building and lofting above the telescope. These useful models provide many insights into understanding the thermal environment of the summit.

An estimate of gas emissions and magmatic gas content from Kilauea volcano

USGS Publications Warehouse

Greenland, L.P.; Rose, William I.; Stokes, J.B.

1985-01-01

Emission rates of CO2 have been measured at Kilauea volcano, Hawaii, in the east-rift eruptive plume and CO2 and SO2 have been measured in the plume from the noneruptive fumaroles in the summit caldera. These data yield an estimate of the loading of Kilauean eruptive gases to the atmosphere and suggest that such estimates may be inferred directly from measured lava volumes. These data, combined with other chemical and geologic data, suggest that magma arrives at the shallow summit reservoir containing (wt.%) 0.32% H2O, 0.32% CO2 and 0.09% S. Magma is rapidly degassed of most of its CO2 in the shallow reservoir before transport to the eruption site. Because this summit degassing yields a magma saturated and in equilibrium with volatile species and because transport of the magma to the eruption site occurs in a zone no shallower than the summit reservoir, we suggest that eruptive gases from Kilauea characteristically should be one of two types: a 'primary' gas from fresh magma derived directly from the mantle and a carbon-depleted gas from magma stored in the summit reservoir. ?? 1995.

Analysis of the impact of recreational trail usage for prioritising management decisions: a regression tree approach

NASA Astrophysics Data System (ADS)

Tomczyk, Aleksandra; Ewertowski, Marek; White, Piran; Kasprzak, Leszek

2016-04-01

The dual role of many Protected Natural Areas in providing benefits for both conservation and recreation poses challenges for management. Although recreation-based damage to ecosystems can occur very quickly, restoration can take many years. The protection of conservation interests at the same as providing for recreation requires decisions to be made about how to prioritise and direct management actions. Trails are commonly used to divert visitors from the most important areas of a site, but high visitor pressure can lead to increases in trail width and a concomitant increase in soil erosion. Here we use detailed field data on condition of recreational trails in Gorce National Park, Poland, as the basis for a regression tree analysis to determine the factors influencing trail deterioration, and link specific trail impacts with environmental, use related and managerial factors. We distinguished 12 types of trails, characterised by four levels of degradation: (1) trails with an acceptable level of degradation; (2) threatened trails; (3) damaged trails; and (4) heavily damaged trails. Damaged trails were the most vulnerable of all trails and should be prioritised for appropriate conservation and restoration. We also proposed five types of monitoring of recreational trail conditions: (1) rapid inventory of negative impacts; (2) monitoring visitor numbers and variation in type of use; (3) change-oriented monitoring focusing on sections of trail which were subjected to changes in type or level of use or subjected to extreme weather events; (4) monitoring of dynamics of trail conditions; and (5) full assessment of trail conditions, to be carried out every 10-15 years. The application of the proposed framework can enhance the ability of Park managers to prioritise their trail management activities, enhancing trail conditions and visitor safety, while minimising adverse impacts on the conservation value of the ecosystem. A.M.T. was supported by the Polish Ministry of Science and Higher Education under Grant 927/MOB/2012/0 ("Mobility Plus" program). P.C.L. White received funding under a UK Natural Environment Research Council grant (NE/K001620/1), with support from the Biodiversity and Ecosystem Service Sustainability (BESS) programme. BESS is a six-year programme (2011-2017) funded by the UK Natural Environment Research Council (NERC) and the Biotechnology and Biological Sciences Research Council (BBSRC) as part of the UK's Living with Environmental Change. (LWEC) programme.

Trail-following behavior ofReticulitermes hesperus Banks (Isoptera: Rhinotermitidae).

PubMed

Grace, J K; Wood, D L; Frankie, G W

1988-02-01

The behavior ofReticulitermes hesperus Banks pseudergates (workers) was assessed on artificial trails containing different concentrations of sternal gland extract. On nongiadient trails, more pseudergates were recruited to trails of greater pheromone concentration, they traveled a greater distance without pausing, and their rate of locomotion increased over that observed on trails of lesser concentration (positive orthokinesis). Of the individuals pausing before completing trails of high concentration, fewer left the trails or reversed direction (negative klinokinesis) than on trails of lower concentration. Termites walking down concentration gradients failed to complete these trails to the low-concentration termini. At a point representing an average decrease of slightly more than 10-fold in the original concentration of pheromone, individuals reversed their direction of travel and returned to the high-concentration terminus. Termites walking up pheromone gradients proceeded to the high-concentration termini without reversing direction.R. hesperus pseudergates are thus able to orient along a gradient of trail pheromone by longitudinal klinotaxis.

Assessing the influence of sustainable trail design and maintenance on soil loss

USGS Publications Warehouse

Marion, Jeff; Wimpey, Jeremy

2017-01-01

Natural-surfaced trail systems are an important infrastructure component providing a means for accessing remote protected natural area destinations. The condition and usability of trails is a critical concern of land managers charged with providing recreational access while preserving natural conditions, and to visitors seeking high quality recreational opportunities and experiences. While an adequate number of trail management publications provide prescriptive guidance for designing, constructing, and maintaining natural-surfaced trails, surprisingly little research has been directed at providing a scientific basis for this guidance. Results from a review of the literature and three scientific studies are presented to model and clarify the influence of factors that substantially influence trail soil loss and that can be manipulated by trail professionals to sustain high traffic while minimizing soil loss over time. Key factors include trail grade, slope alignment angle, tread drainage features, and the amount of rock in tread substrates. A new Trail Sustainability Rating is developed and offered as a tool for evaluating or improving the sustainability of existing or new trails.

Energy Department to Host First Sustainable Transportation Summit

ScienceCinema

Sarkar, Reuben

2018-01-16

On July 11-12, mobility and transportation leaders from across the country are coming to Washington, D.C. for the inaugural Sustainable Transportation Summit hosted by the Office of Energy Efficiency and Renewable Energy (EERE).

TRIBAL LEADERS ENVIRONMENTAL SUMMIT

EPA Science Inventory

This annual conference includes general and breakout sessions relating to science or environmental management in such areas as solid waste, community planning, environmental education, contaminants, capacity building and more. The October 2000 Tribal Summit was held in Anchorage...

36 CFR 1253.6 - Records Centers.

Code of Federal Regulations, 2011 CFR

2011-07-01

...., Chicago, IL 60629-5898. The telephone number is 773-948-9000. (h) NARA—Central Plains Region (Lee's Summit, MO) is located at 200 Space Center Drive, Lee's Summit, MO 64064-1182. The telephone number is 816...

Energy Department to Host First Sustainable Transportation Summit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarkar, Reuben

2016-06-29

On July 11-12, mobility and transportation leaders from across the country are coming to Washington, D.C. for the inaugural Sustainable Transportation Summit hosted by the Office of Energy Efficiency and Renewable Energy (EERE).

TNF-related apoptosis-inducing ligand (TRAIL): A new path to anti-cancer therapies

PubMed Central

Holoch, Peter A.; Griffith, Thomas S.

2009-01-01

Since its discovery in 1995, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor super family, has been under intense focus because of its remarkable ability to induce apoptosis in malignant human cells while leaving normal cells unscathed. Consequently, activation of the apoptotic signaling pathway from the death-inducing TRAIL receptors provides an attractive, biologically-targeted approach to cancer therapy. A great deal of research has focused on deciphering the TRAIL receptor signaling cascade and intracellular regulation of this pathway, as many human tumor cells possess mechanisms of resistance to TRAIL-induced apoptosis. This review focuses on the currently state of knowledge regarding TRAIL signaling and resistance, the preclinical development of therapies targeted at TRAIL receptors and modulators of the pathway, and the results of clinical trials for cancer treatment that have emerged from this base of knowledge. TRAIL-based approaches to cancer therapy vary from systemic administration of recombinant, soluble TRAIL protein with or without the combination of traditional chemotherapy, radiation or novel anticancer agents to agonistic monoclonal antibodies directed against functional TRAIL receptors to TRAIL gene transfer therapy. A better understanding of TRAIL resistance mechanisms may allow for the development of more effective therapies that exploit this cell-mediated pathway to apoptosis. PMID:19836385

Assessing trail conditions in protected areas: Application of a problem-assessment method in Great Smoky Mountains National Park, USA

USGS Publications Warehouse

Leung, Y.-F.; Marion, J.

1999-01-01

The degradation of trail resources associated with expanding recreation and tourism visitation is a growing management problem in protected areas worldwide. In order to make judicious trail and visitor management decisions, protected area managers need objective and timely information on trail resource conditions. This paper introduces a trail survey method that efficiently characterizes the lineal extent of common trail problems. The method was applied to a large sample of trails within Great Smoky Mountains National Park, a highuse protected area in the USA. The Trail ProblemAssessment Method (TPAM) employs a continuous search for multiple indicators of predefined tread problems, yielding census data documenting the location, occurrence and extent of each problem. The present application employed 23 different indicators in three categories to gather inventory, resource condition, and design and maintenance data of each surveyed trail. Seventy-two backcountry hiking trails (528 km), or 35% of the Park's total trail length, were surveyed. Soil erosion and wet soil were found to be the two most common impacts on a lineal extent basis. Trails with serious tread problems were well distributed throughout the Park, although wet muddy treads tended to be concentrated in areas where horse use was high. The effectiveness of maintenance features installed to divert water from trail treads was also evaluated. Water bars were found to be more effective than drainage dips. The TPAM was able to provide Park managers with objective and quantitative information for use in trail planning, management and maintenance decisions, and is applicable to other protected areas elsewhere with different environmental and impact characteristics.

A Summit of Sages exploring social justice and nursing: an interview with Marie Manthey and Joanne Disch.

PubMed

Manthey, Marie; Disch, Joanne

2008-01-01

Beth Beaty discusses with Marie Manthey and Joanne Disch, organizers of the recent Summit of Sages, their efforts to bring nurses from around the world together to think and talk about social justice. They share their belief that social justice is a part of the fabric of nursing. A Summit of Sages encouraged participants to a higher level of involvement in their communities. Marie and Joanne hope their example will lead to expanded cooperation between businesses and academic institutions.

30 CFR 75.600 - Trailing cables; flame resistance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cables; flame resistance. 75.600... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.600 Trailing cables; flame resistance. [Statutory Provisions] Trailing cables used in coal mines shall meet the...

30 CFR 75.606 - Protection of trailing cables.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection of trailing cables. 75.606 Section... AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.606 Protection of trailing cables. [Statutory Provisions] Trailing cables shall be adequately protected to prevent damage by...

76 FR 71601 - Record of Decision, Long Walk National Historic Trail Feasibility Study/Abbreviated Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... National Historic Trail Feasibility Study/Abbreviated Final Environmental Impact Statement, National Trails... Decision on the Abbreviated Final Environmental Impact Statement for the Long Walk National Historic Trail... Final Environmental Impact Statement for the Long Walk National Historic Trail Feasibility Study...

Snails and their trails: the multiple functions of trail-following in gastropods.

PubMed

Ng, Terence P T; Saltin, Sara H; Davies, Mark S; Johannesson, Kerstin; Stafford, Richard; Williams, Gray A

2013-08-01

Snails are highly unusual among multicellular animals in that they move on a layer of costly mucus, leaving behind a trail that can be followed and utilized for various purposes by themselves or by other animals. Here we review more than 40 years of experimental and theoretical research to try to understand the ecological and evolutionary rationales for trail-following in gastropods. Data from over 30 genera are currently available, representing a broad taxonomic range living in both aquatic and terrestrial environments. The emerging picture is that the production of mucus trails, which initially was an adaptation to facilitate locomotion and/or habitat extension, has evolved to facilitate a multitude of additional functions. Trail-following supports homing behaviours, and provides simple mechanisms for self-organisation in groups of snails, promoting aggregation and thus relieving desiccation and predation pressures. In gastropods that copulate, trail-following is an important component in mate-searching, either as an alternative, or in addition to the release of water- or air-borne pheromones. In some species, this includes a capacity of males not only to identify trails of conspecifics but also to discriminate between trails laid by females and males. Notably, trail discrimination seems important as a pre-zygotic barrier to mating in some snail species. As production of a mucus trail is the most costly component of snail locomotion, it is also tempting to speculate that evolution has given rise to various ways to compensate for energy losses. Some snails, for example, increase energy intake by eating particles attached to the mucus of trails that they follow, whereas others save energy through reducing the production of their own mucus by moving over previously laid mucus trails. Trail-following to locate a prey item or a mate is also a way to save energy. While the rationale for trail-following in many cases appears clear, the basic mechanisms of trail discrimination, including the mechanisms by which many snails determine the polarity of the trail, are yet to be experimentally determined. Given the multiple functions of trail-following we propose that future studies should adopt an integrated approach, taking into account the possibility of the simultaneous occurrence of many selectively advantageous roles of trail-following behaviour in gastropods. We also believe that future opportunities to link phenotypic and genotypic traits will make possible a new generation of research projects in which gastropod trail-following, its multitude of functions and evolutionary trade-offs can be further elucidated. © 2013 The Authors. Biological Reviews © 2013 Cambridge Philosophical Society.

Joint analysis of deformation, gravity, and lava lake elevation reveals temporal variations in lava lake density at Kilauea Volcano, Hawaii

NASA Astrophysics Data System (ADS)

Carbone, Daniele; Poland, Michael; Patrick, Matthew

2015-04-01

We find a tight correlation between (i) changes in lava level within the summit eruptive vent at Kilauea Volcano, Hawaii, observed for at least 2 years since early 2011, and (ii) ground deformation in the vicinity of the vent. The observed correlation indicates that changing pressure within the shallow magma reservoir feeding the lava lake influences both deformation and lava level. However, those two parameters are related to chamber pressure through different properties, namely, the density of the lava filling the vent (for the lava level) and the size/position of the reservoir plus the elastic parameters of the host rock (for the deformation). Joint analyses in the time and frequency domains of lava level (determined from thermal camera imagery of the lava lake) and tilt measured on a borehole instrument (~2 km from the summit vent) reveal a good correlation throughout the studied period. The highest correlation occurs over periods ranging between 1 and 20 days. The ratio between lava level and tilt is not constant over time, however. Using data from a continuously recording gravimeter located near the rim of the summit eruptive vent, we demonstrate that the tilt-lava level ratio is controlled by the fluctuations in the density of the lava inside the vent (i.e., its degree of vesicularity). A second continuous gravimeter was installed near the summit eruptive vent in 2014, providing a new observation point for gravity change associated with summit lava lave activity to test models developed from the previously existing instrument. In addition, a continuous gravimeter was installed on the rim of the Puu Oo eruptive vent on Kilauea's East Rift Zone in 2013. Puu Oo is connected via the subvolcanic magma plumbing system to the summit eruptive vent and often deforms in concert with the summit. This growing network of continuously recording gravimeters at Kilauea can be used to examine correlations in gravity change associated with variations in eruptive activity across the volcano.

Geophysical observations of Kilauea Volcano, Hawaii, 2. Constraints on the magma supply during November 1975-September 1977

USGS Publications Warehouse

Dzurisin, D.; Anderson, L.A.; Eaton, G.P.; Koyanagi, R.Y.; Lipman, P.W.; Lockwood, J.P.; Okamura, R.T.; Puniwai, G.S.; Sako, M.K.; Yamashita, K.M.

1980-01-01

Following a 22-month hiatus in eruptive activity, Kilauea volcano extruded roughly 35 ?? 106 m3 of tholeiitic basalt from vents along its middle east rift zone during 13 September-1 October, 1977. The lengthy prelude to this eruption began with a magnitude 7.2 earthquake on 29 November, 1975, and included rapid summit deflation episodes in June, July, and August 1976 and February 1977. Synthesis of seismic, geodetic, gravimetric, and electrical self-potential observations suggests the following model for this atypical Kilauea eruptive cycle. Rapid summit deflation initiated by the November 1975 earthquake reflected substantial migration of magma from beneath the summit region of Kilauea into the east and southwest rift zones. Simultaneous leveling and microgravity observations suggest that 40-90 ?? 106 m3 of void space was created within the summit magma chamber as a result of the earthquake. If this volume was filled by magma from depth before the east rift zone intrusive event of June 1976, the average rate of supply was 6-13 ?? 106 m3/month, a rate that is consistent with the value of 9 ?? 106 m3/month suggested from observations of long-duration Kilauea eruptions. Essentially zero net vertical change was recorded at the summit during the 15-month period beginning with the June 1976 intrusion and ending with the September 1977 eruption. This fact suggests that most magma supplied from depth during this interval was eventually delivered to the east rift zone, at least in part during four rapid summit deflation episodes. Microearthquake epicenters migrated downrift to the middle east rift zone for the first time during the later stages of the February 1977 intrusion, an occurrence presumably reflecting movement of magma into the eventual eruptive zone. This observation was confirmed by tilt surveys in May 1977 that revealed a major inflation center roughly 30 km east of the summit in an area of anomalous steaming and forest kill first noted in March 1976. ?? 1980.

Database for the Geologic Map of the Summit Region of Kilauea Volcano, Hawaii

USGS Publications Warehouse

Dutton, Dillon R.; Ramsey, David W.; Bruggman, Peggy E.; Felger, Tracey J.; Lougee, Ellen; Margriter, Sandy; Showalter, Patrick; Neal, Christina A.; Lockwood, John P.

2007-01-01

INTRODUCTION The area covered by this map includes parts of four U.S. Geological Survey (USGS) 7.5' topographic quadrangles (Kilauea Crater, Volcano, Ka`u Desert, and Makaopuhi). It encompasses the summit, upper rift zones, and Koa`e Fault System of Kilauea Volcano and a part of the adjacent, southeast flank of Mauna Loa Volcano. The map is dominated by products of eruptions from Kilauea Volcano, the southernmost of the five volcanoes on the Island of Hawai`i and one of the world's most active volcanoes. At its summit (1,243 m) is Kilauea Crater, a 3 km-by-5 km collapse caldera that formed, possibly over several centuries, between about 200 and 500 years ago. Radiating away from the summit caldera are two linear zones of intrusion and eruption, the east and the southwest rift zones. Repeated subaerial eruptions from the summit and rift zones have built a gently sloping, elongate shield volcano covering approximately 1,500 km2. Much of the volcano lies under water: the east rift zone extends 110 km from the summit to a depth of more than 5,000 m below sea level; whereas, the southwest rift zone has a more limited submarine continuation. South of the summit caldera, mostly north-facing normal faults and open fractures of the Koa`e Fault System extend between the two rift zones. The Koa`e Fault System is interpreted as a tear-away structure that accommodates southward movement of Kilauea's flank in response to distension of the volcano perpendicular to the rift zones. This digital release contains all the information used to produce the geologic map published as USGS Geologic Investigations Series I-2759 (Neal and Lockwood, 2003). The main component of this digital release is a geologic map database prepared using ArcInfo GIS. This release also contains printable files for the geologic map and accompanying descriptive pamphlet from I-2759.

30 CFR 75.826 - High-voltage trailing cables.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage trailing cables. 75.826 Section 75...-Voltage Longwalls § 75.826 High-voltage trailing cables. High-voltage trailing cables must: (a) Meet existing trailing cable requirements and the approval requirements of the high-voltage continuous mining...

30 CFR 75.601 - Short circuit protection of trailing cables.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Short circuit protection of trailing cables. 75... MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.601 Short circuit protection of trailing cables. [Statutory Provisions] Short circuit protection for trailing cables...

30 CFR 77.603 - Clamping of trailing cables to equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Clamping of trailing cables to equipment. 77.603 Section 77.603 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL... UNDERGROUND COAL MINES Trailing Cables § 77.603 Clamping of trailing cables to equipment. Trailing cables...

30 CFR 75.603 - Temporary splice of trailing cable.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Temporary splice of trailing cable. 75.603... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.603 Temporary splice of trailing cable. [Statutory Provision] One temporary splice may be made in any trailing cable...

76 FR 35468 - Star-Spangled Banner National Historic Trail Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... DEPARTMENT OF THE INTERIOR National Park Service Star-Spangled Banner National Historic Trail... the Advisory Committee on the Star-Spangled Banner National Historic Trail will hold a meeting. Designated through an amendment to the National Trails System Act (16 U.S.C. 1241), the trail consists of...

30 CFR 75.602 - Trailing cable junctions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cable junctions. 75.602 Section 75.602... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.602 Trailing cable junctions. [Statutory Provision] When two or more trailing cables junction to the same distribution center, means shall...

30 CFR 75.604 - Permanent splicing of trailing cables.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Permanent splicing of trailing cables. 75.604... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.604 Permanent splicing of trailing cables. [Statutory Provisions] When permanent splices in trailing cables are made...

75 FR 29359 - Draft Environmental Impact Statement for the Tamiami Trail Modifications: Next Steps Project...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-25

... Tamiami Trail Modifications: Next Steps Project, Everglades National Park Tamiami Trail Modifications... Interior. ACTION: Notice of availability of the Draft Environmental Impact Statement for the Tamiami Trail... Statement (DEIS) for the Tamiami Trail (U.S. Highway 41) Modifications: Next Steps Project for Everglades...

30 CFR 77.602 - Permanent splicing of trailing cables.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Permanent splicing of trailing cables. 77.602... COAL MINES Trailing Cables § 77.602 Permanent splicing of trailing cables. When permanent splices in trailing cables are made, they shall be: (a) Mechanically strong with adequate electrical conductivity; (b...

30 CFR 77.604 - Protection of trailing cables.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection of trailing cables. 77.604 Section 77.604 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY... MINES Trailing Cables § 77.604 Protection of trailing cables. Trailing cables shall be adequately...

30 CFR 77.606 - Energized trailing cables; handling.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Energized trailing cables; handling. 77.606... COAL MINES Trailing Cables § 77.606 Energized trailing cables; handling. Energized medium- and high-voltage trailing cables shall be handled only by persons wearing protective rubber gloves (see § 77.606-1...

30 CFR 75.605 - Clamping of trailing cables to equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Clamping of trailing cables to equipment. 75... MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.605 Clamping of trailing cables to equipment. [Statutory Provisions] Trailing cables shall be clamped to...

75 FR 12254 - Official Trail Marker for the Ala Kahakai National Historic Trail

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-15

... DEPARTMENT OF THE INTERIOR National Park Service Official Trail Marker for the Ala Kahakai National Historic Trail AGENCY: National Park Service, Interior. ACTION: Official Insignia, Designation. Authority: National Trails System Act, 16 U.S.C. 1241(a) and l246(c) and Protection of Official Badges...

36 CFR 212.56 - Identification of designated roads, trails, and areas.

Code of Federal Regulations, 2010 CFR

2010-07-01

... roads, trails, and areas. 212.56 Section 212.56 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE TRAVEL MANAGEMENT Designation of Roads, Trails, and Areas for Motor Vehicle Use § 212.56 Identification of designated roads, trails, and areas. Designated roads, trails, and areas...

30 CFR 75.607 - Breaking trailing cable and power cable connections.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Breaking trailing cable and power cable... LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.607 Breaking trailing cable and power cable connections. [Statutory Provisions] Trailing cable and...

30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection; disconnecting devices. Short-circuit protection for trailing cables shall be provided by an automatic circuit...

75 FR 37463 - Official Trail Marker for the Star-Spangled Banner National Historic Trail

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

... DEPARTMENT OF THE INTERIOR National Park Service Official Trail Marker for the Star-Spangled Banner National Historic Trail AGENCY: National Parks Service, Interior. ACTION: Official Insignia, Designation. Authority: National Trails System Act, 16 U.S.C. 124(a) and 1246(c) and Protection of Official...

30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

Code of Federal Regulations, 2014 CFR

2014-07-01

... capacity in each ungrounded conductor. Disconnecting devices used to disconnect power from trailing cables... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection...

30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

Code of Federal Regulations, 2013 CFR

2013-07-01

... capacity in each ungrounded conductor. Disconnecting devices used to disconnect power from trailing cables... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection...

30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

Code of Federal Regulations, 2012 CFR

2012-07-01

... capacity in each ungrounded conductor. Disconnecting devices used to disconnect power from trailing cables... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection...

30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... capacity in each ungrounded conductor. Disconnecting devices used to disconnect power from trailing cables... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection...

Chemical communication in the dacetine antDaceton armigerum (Hymenoptera: Formicidae).

PubMed

Hölldobler, B; Palmer, J M; Moffett, M W

1990-04-01

Contrary to previous assumptions,Daceton armigerum, the largest ant in the myrmicine tribe Dacetini, employs trail communication. We identified two anatomical sources of trail pheromones: Trails drawn with poison gland contents can last for more than seven days. Trails drawn with the newly discovered sternal glands (in the VIth and VIIth abdominal sternites) are effective but relatively short-lived. In addition, our bioassays revealed that the contents of the mandibular glands elicit alarm behavior, and secretions from the pygidial gland release attraction. When tested with artificial poison gland trails from seven other myrmicine species,Daceton did not exhibit trail following behavior. We confirmed, however, previous findings thatAtta respond toDaceton poison gland trails andSolenopsis followDaceton Dufour's gland trails.

The Effect of Nozzle Trailing Edge Thickness on Jet Noise

NASA Technical Reports Server (NTRS)

Henderson, Brenda; Kinzie, Kevin; Haskin, Henry

2004-01-01

The effect of nozzle trailing edge thickness on broadband acoustic radiation and the production of tones is investigated for coannular nozzles. Experiments were performed for a core nozzle trailing edge thickness between 0.38 mm and 3.17 mm. The on-set of discrete tones was found to be predominantly affected by the velocity ratio, the ratio of the fan velocity to the core velocity, although some dependency on trailing edge thickness was also noted. For a core nozzle trailing edge thickness greater than or equal to 0.89 mm, tones were produced for velocity ratios between 0.91 and 1.61. For a constant nozzle trailing edge thickness, the frequency varied almost linearly with the core velocity. The Strouhal number based on the core velocity changed with nozzle trailing edge thickness and varied between 0.16 and 0.2 for the core nozzles used in the experiments. Increases in broadband noise with increasing trailing edge thickness were observed for tone producing and non-tone producing conditions. A variable thickness trailing edge (crenellated) nozzle resulted in no tonal production and a reduction of the broadband trailing edge noise relative to that of the corresponding constant thickness trailing edge.

Travel to, and use of, twenty-one Michigan trails.

PubMed

Price, Anna E; Reed, Julian A; Grost, Lisa; Harvey, Christina; Mantinan, Karah

2013-03-01

This study examined trail use among 857 trail users on 21 trails in Michigan from 2008 to 2011 using a valid and reliable intercept survey. Most of the 857 participants traveled to the trail from their home (92.6%), lived within 15 min of the trails (74.8%), and used active transport to travel to the trails 69.7%. The odds of active transport to the trails were greater among those who had not graduated high school (OR=3.49; 95% CI=1.02, 11.99) and high school graduates (OR=7.432; 95% CI=2.02, 27.30) compared to college graduates. Whites and adults also had greater odds of active transport than non-Whites (OR=3.160, 95% CI: 1.65, 6.05), and older adults (OR=1.75; 95% CI: 1.20, 2.54). The majority of respondents (89.7%) reported using trails for recreational purposes. A significantly greater proportion of females (73.3%) compared to males (64.7%) reported using the trail with others. The findings from this study might enable health and parks and recreation professionals to better promote physical activity on trails. Copyright © 2013 Elsevier Inc. All rights reserved.

Hexyl decanoate, the first trail pheromone compound identified in a stingless bee, Trigona recursa.

PubMed

Jarau, Stefan; Schulz, Claudia M; Hrncir, Michael; Francke, Wittko; Zucchi, Ronaldo; Barth, Friedrich G; Ayasse, Manfred

2006-07-01

Foragers of many species of stingless bees guide their nestmates to food sources by means of scent trails deposited on solid substrates between the food and the nest. The corresponding trail pheromones are generally believed to be produced in the mandibular glands, although definitive experimental proof has never been provided. We tested the trail following behavior of recruits of Trigona recursa in field experiments with artificial scent trails branching off from natural scent trails of this stingless bee. First-time recruits (newcomers) did not follow these trails when they were laid with pure solvent or mandibular gland extract. However, they did follow trails made with labial gland extract. Chemical analyses of labial gland secretions revealed that hexyl decanoate was the dominant component (72.4 +/- 1.9% of all volatiles). Newcomers were significantly attracted to artificial trails made with synthetic hexyl decanoate, demonstrating its key function in eliciting scent-following behavior. According to our experiments with T. recursa, the trail pheromone is produced in the labial glands and not in the mandibular glands. Hexyl decanoate is the first component of a trail pheromone identified and proved to be behaviorally active in stingless bees.

Stingless bees (Scaptotrigona pectoralis) learn foreign trail pheromones and use them to find food.

PubMed

Reichle, Christian; Aguilar, Ingrid; Ayasse, Manfred; Jarau, Stefan

2011-03-01

Foragers of several species of stingless bees (Hymenoptera, Apidae and Meliponini) deposit pheromone marks in the vegetation to guide nestmates to new food sources. These pheromones are produced in the labial glands and are nest and species specific. Thus, an important question is how recruited foragers recognize their nestmates' pheromone in the field. We tested whether naïve workers learn a specific trail pheromone composition while being recruited by nestmates inside the hive in the species Scaptotrigona pectoralis. We installed artificial scent trails branching off from trails deposited by recruiting foragers and registered whether newly recruited bees follow these trails. The artificial trails were baited with trail pheromones of workers collected from foreign S. pectoralis colonies. When the same foreign trail pheromone was presented inside the experimental hives while recruitment took place a significant higher number of bees followed the artificial trails than in experiments without intranidal presentation. Our results demonstrate that recruits of S. pectoralis can learn the composition of specific trail pheromone bouquets inside the nest and subsequently follow this pheromone in the field. We, therefore, suggest that trail pheromone recognition in S. pectoralis is based on a flexible learning process rather than being a genetically fixed behaviour.

The beneficial pleiotropic effects of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) within the vasculature: A review of the evidence.

PubMed

Forde, Hannah; Harper, Emma; Davenport, Colin; Rochfort, Keith D; Wallace, Robert; Murphy, Ronan P; Smith, Diarmuid; Cummins, Philip M

2016-04-01

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to the tumour necrosis factor (TNF) cytokine superfamily. TRAIL is expressed by numerous cell types including vascular cells, immune cells and adipocytes. Although originally thought to induce apoptosis in malignant or transformed cells only, it is now known that TRAIL can bind up to 5 distinct receptors to activate complex signalling pathways, and is capable of exerting pleiotropic effects in non-transformed cells. In this respect, a number of clinical and animal studies point to the potential vasoprotective influence of TRAIL, with TRAIL deficiency being linked to accelerated atherosclerosis and vascular calcification. Moreover, exogenous TRAIL administration has been shown to exhibit anti-atherosclerotic activity in-vivo. In-vitro studies on TRAIL in this context have yielded conflicting results however, with evidence of both pro-atherogenic and vasoprotective effects ascribed to TRAIL. Notwithstanding these various studies, mechanistic information on the precise nature of TRAIL-mediated injury/protection within the vasculature, as well as the identity of the downstream molecular/cellular targets of TRAIL, is still quite limited. In this review, we will summarize our current knowledge of TRAIL regulation, signalling mechanisms, and its apparent involvement in CVD pathogenesis as a prelude to examining the existing evidence for TRAIL-mediated vasoprotection. To this end, extensive in vitro, in vivo, and clinical studies will be reviewed and critical findings highlighted. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Role of trail pheromone in foraging and processionary behavior of pine processionary caterpillars Thaumetopoea pityocampa.

PubMed

Fitzgerald, T D

2003-03-01

Although caterpillars of Thaumetopoea pityocamnpa may mark their pathways with silk, this study shows that the material is essential to neither the elicitation nor maintenance of trail-following or processionary behavior. Trail following is dependent upon a pheromone the caterpillars deposit by brushing the ventral surfaces of the tips of their abdomens against the substate. Earlier instars are strongly bound to their trail system; in the laboratory, caterpillars followed circular trails continuously for as long as 12 hr before breaking away from them. The trail pheromone is long-lived and soluble in nonpolar solvents, but its volatilization or degradation allows the caterpillars to distinguish new from aged trails. In contrast to trail following, processionary behavior, the head-to-tail, single-file movement of the caterpillars is dependent on neither silk nor the trail pheromone. Stimuli associated with setae found on the tip of the abdomen of the precedent caterpillar serve to hold processions together, and such stimuli take priority over those associated with either the trail pheromone or silk. Although the caterpillars discern trail strength and choose stronger over weaker trails, the trail marking system of the processionary caterpillar appears less sophisticated than those of other, previously studied species of social caterpillars, and colonies are relatively inefficient in abandoning exhausted feeding sites in favor of new food finds. In laboratory studies, females were more likely to lead processions than males, and leaders, regardless of gender, expended more energy in locomotion than followers.

Promoting and developing a trail network across suburban, rural, and urban communities.

PubMed

Schasberger, Michele G; Hussa, Carol S; Polgar, Michael F; McMonagle, Julie A; Burke, Sharon J; Gegaris, Andrew J

2009-12-01

The Wyoming Valley Wellness Trails Partnership received an Active Living by Design grant late in 2003 for a project centered on a growing trail network linking urban, suburban, and rural communities in northeast Pennsylvania, a former coal region, in order to increase physical activity among residents. The partnership conducted research, collected information, created promotional documents, worked with partners on events and programs, and participated in trail planning. Local trail organizations continued planning and construction toward developing a trail network. Other partners spearheaded policy change in schools and worksites and worked toward downtown revitalization. The partnership assisted these efforts by providing a forum in which organizations could meet. The partnership became a central resource for information about local parks, trails, and outdoor recreational activities. The partnership increased awareness and use of recreational facilities. Trail partners constructed 22 miles of walking and biking trails. The partnership took advantage of an allied effort that created organizational capacity for wellness in schools and worksites. Messages promoting social and entertainment benefits of physical activity were more successful than those promoting health benefits. The existence of multiple small, independent trail organizations can help advance trail development through concurrent development efforts. Urban, suburban, and rural residents' conceptions of walkability may differ. Trails provide options for recreational and transportation-related physical activity across urban, suburban, and rural landscapes that are supported by all constituents. Trail builders can be strong allies in bringing active living to suburban and rural places.

Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma.

PubMed

Brincks, Erik L; Kucaba, Tamara A; James, Britnie R; Murphy, Katherine A; Schwertfeger, Kathryn L; Sangwan, Veena; Banerjee, Sulagna; Saluja, Ashok K; Griffith, Thomas S

2015-12-01

Renal cell carcinoma (RCC) is resistant to traditional cancer therapies, and metastatic RCC (mRCC) is incurable. The shortcomings in current therapeutic options for patients with mRCC provide the rationale for the development of novel treatment protocols. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has proven to be a potent inducer of tumor cell death in vitro and in vivo, and a number of TRAIL death receptor agonists (recombinant TRAIL or TRAIL death receptor-specific mAb) have been developed and tested clinically. Unfortunately the clinical efficacy of TRAIL has been underwhelming and is likely due to a number of possible mechanisms that render tumors resistant to TRAIL, prompting the search for drugs that increase tumor cell susceptibility to TRAIL. The objective of this study was to determine the effectiveness of combining the diterpene triepoxide triptolide, or its water-soluble prodrug, Minnelide, with TRAIL receptor agonists against RCC in vitro or in vivo, respectively. TRAIL-induced apoptotic death of human RCC cells was increased in the presence of triptolide. The triptolide-induced sensitization was accompanied by increased TRAIL-R2 (DR5) and decreased heat shock protein 70 expression. In vivo treatment of mice bearing orthotopic RCC (Renca) tumors showed the combination of Minnelide and agonistic anti-DR5 mAb significantly decreased tumor burden and increased animal survival compared to either therapy alone. Our data suggest triptolide/Minnelide sensitizes RCC cells to TRAIL-induced apoptosis through altered TRAIL death receptor and heat shock protein expression. © 2015 FEBS.

Triptolide Enhances the Tumoricidal Activity of TRAIL Against Renal Cell Carcinoma

PubMed Central

James, Britnie R.; Murphy, Katherine A.; Schwertfeger, Kathryn L.; Sangwan, Veena; Banerjee, Sulagna; Saluja, Ashok K.; Griffith, Thomas S.

2015-01-01

Renal cell carcinoma (RCC) is resistant to traditional cancer therapies, and metastatic RCC (mRCC) is incurable. The shortcomings in current therapeutic options for patients with mRCC provide the rationale for the development of novel treatment protocols. TNF-related apoptosis-inducing ligand (TRAIL) has proven to be a potent inducer of tumor cell death in vitro and in vivo, and a number of TRAIL death receptor agonists (recombinant TRAIL or TRAIL death receptor-specific mAb) has been developed and tested clinically. Unfortunately the clinical efficacy of TRAIL has been underwhelming and is likely due to a number of possible mechanisms that render tumors resistant to TRAIL, prompting the search for drugs that increase tumor cell susceptibility to TRAIL. The objective of this study was to determine the effectiveness of combining the diterpene triepoxide triptolide, or its water-soluble prodrug, Minnelide, with TRAIL receptor agonists against RCC in vitro or in vivo, respectively. TRAIL-induced apoptotic death of human RCC cells was increased in the presence of triptolide. The triptolide-induced sensitization was accompanied by increased TRAIL-R2 (DR5) and decreased HSP70 expression. In vivo treatment of mice bearing orthotopic RCC (Renca) tumors showed the combination of Minnelide and agonistic anti-DR5 mAb significantly decreased tumor burden and increased animal survival compared to either therapy alone. Our data suggest triptolide/Minnelide sensitizes RCC cells to TRAIL-induced apoptosis through altered TRAIL death receptor and heat shock protein expression. PMID:26426449

Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis.

PubMed Central

Siegmund, Daniela; Hadwiger, Philipp; Pfizenmaier, Klaus; Vornlocher, Hans-Peter; Wajant, Harald

2002-01-01

BACKGROUND: Most tumors express death receptors and their activation represents a potential selective approach in cancer treatment. The most promising candidate for tumor selective death receptor-activation is tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L, which activates the death receptors TRAIL-R1 and TRAIL-R2, and induces apoptosis preferentially in tumor cells but not in normal tissues. However, many cancer cells are not or only moderately sensitive towards TRAIL and require cotreatment with irradiation or chemotherapy to yield a therapeutically reasonable apoptotic response. Because chemotherapy can have a broad range of unwanted side effects, more specific means for sensitizing tumor cells for TRAIL are desirable. The expression of the cellular FLICE-like inhibitory protein (cFLIP) is regarded as a major cause of TRAIL resistance. We therefore analyzed the usefulness of targeting FLIP to sensitize tumor cells for TRAIL-induced apoptosis. MATERIALS AND METHODS: To selectively interfere with expression of cFLIP short double-stranded RNA oligonucleotides (small interfering RNAs [siRNAs]) were introduced in the human cell lines SV80 and KB by electroporation. Effects of siRNA on FLIP expression were analyzed by Western blotting and RNase protection assay and correlated with TRAIL sensitivity upon stimulation with recombinant soluble TRAIL and TRAIL-R1- and TRAIL-R2-specific agonistic antibodies. RESULTS: FLIP expression can be inhibited by RNA interference using siRNAs, evident from reduced levels of FLIP-mRNA and FLIP protein. Inhibition of cFLIP expression sensitizes cells for apoptosis induction by TRAIL and other death ligands. In accordance with the presumed function of FLIP as an inhibitor of death receptor-induced caspase-8 activation, down-regulation of FLIP by siRNAs enhanced TRAIL-induced caspase-8 activation. CONCLUSION: Inhibition of FLIP expression was sufficient to sensitize tumor cells for TRAIL-induced apoptosis. The combination of TRAIL and FLIP-targeting siRNA could therefore be a useful strategy to attack cancer cells, which are resistant to TRAIL alone. PMID:12520089

President Barack Obama at UN Climate Change Summit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Obama, Barack

2009-09-22

In his first address to the United Nations as Commander-in- Chief, President Obama addresses the pressing issue of climate change. The one-day UN summit brought together delegations from 90 nations. September 22, 2009 (Public Domain)

1. Historic American Buildings Survey Photocopy of old view, date ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey Photocopy of old view, date unknown From collection of Anna B. Scherer, Lees Summit, Mo. NORTH FACADE - Longview Farm, Hog & Sale Barn, Longview Road, Lees Summit, Jackson County, MO

Don't wait for Paris summit to improve health.

PubMed

Soares, Andréia Azevedo; Figueres, Christiana

2015-11-01

How developing countries will make the transition to sustainable clean-energy economies is a major challenge for the United Nations summit that opens in Paris this month. Christiana Figueres talks to Andréia Azevedo Soares.

Kayenta Township Building & Safety Department, Tribal Green Building Code Summit Presentation

EPA Pesticide Factsheets

Tribal Green Building Code Summit Presentation by Kayenta Township Building & Safety Department showing how they established the building department, developed a code adoption and enforcement process, and hired staff to carry out the work.

NASA Education Stakeholder's Summit

NASA Image and Video Library

2010-09-12

Marion C. Blakey, President and CEO, Aerospace Industries Association, addresses guests at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

NASA Education Stakeholder's Summit

NASA Image and Video Library

2010-09-12

Leland Melvin, right, Education Design Team Co-Chair and NASA Astronaut, speaks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

President Barack Obama at UN Climate Change Summit

ScienceCinema

Obama, Barack

2018-02-13

In his first address to the United Nations as Commander-in- Chief, President Obama addresses the pressing issue of climate change. The one-day UN summit brought together delegations from 90 nations. September 22, 2009 (Public Domain)

Summit Equipment & Supplies, Inc. Five-Year Reviews

EPA Pesticide Factsheets

The Summit Equipment & Supplies site in Akron, OH is a former salvage yard and scrap metal facility with PCB contamination of soil on-site, off-site movement of the PCBs, and ground water contamination under the site.

Application of photogrammetry to the study of volcano-glacier interactions on Mount Wrangell, Alaska

NASA Technical Reports Server (NTRS)

Benson, C. S.; Follett, A. B.

1986-01-01

Most Alaskan volcanoes are glacier covered and provide excellent opportunities to study interactions between glaciers and volcanoes. The present paper is concerned with such a study, taking into account the Mt. Wrangell (4317 m) which is the northernmost active volcano (solfatara activity) on the Pacific Rim (62 deg N; 144 deg W). While the first photographs on the summit of Mt. Wrangell were published more than 75 years ago, research there began in 1953 and 1954. Satellite images reveal activity at the summit of Mt. Wrangell. However, the resolution is not sufficient for conducting important measurements regarding ice volume losses. For this reason, vertical aerial photographs of the summit were obtained, and a field trip to the summit was conducted. Aspects of photogrammetry are discussed, taking into account questions of ground control, aerial photography, topographic mapping, digital cross sections, and orthophotos.

2012 ARPA-E Energy Innovation Summit: Profiling Foro Energy: High Power Lasers - Long Distances (Performer Video)

ScienceCinema

Moxley, John; Zediker, Mark; Chu, Steven; Deutch, Paul

2018-05-30

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These "performer videos" highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video from Foro Energy are Joel Moxley, Founder and CEO, Mark Zediker, Founder and CTO, and Paul Deutch, President and COO. Steven Chu, Secretary of Energy, also appears briefly in this video to praise the accomplishment of a high powered laser that can transmit that power long distances for faster and more powerful drilling of geothermal, oil, and gas wells.

Elongate summit calderas as Neogene paleostress indicators in Antarctica

USGS Publications Warehouse

Paulsen, T.S.; Wilson, T.J.

2007-01-01

The orientations and ages of elongate summit calderas on major polygenetic volcanoes were compiled to document Miocene to Pleistocene Sh (minimum horizontal stress) directions on the western and northern flanks of the West Antarctic rift system. Miocene to Pleistocene summit calderas along the western Ross Sea show relatively consistent ENE long axis trends, which are at a high angle to the Transantarctic Mountain Front and parallel to the N77ºE Sh direction at Cape Roberts. The elongation directions of many Miocene to Pleistocene summit calderas in Marie Byrd Land parallel the alignment of polygenetic volcanoes in which they occur, except several Pleistocene calderas with consistent NNE to NE trends. The overall pattern of elongate calderas in Marie Byrd Land is probably due to a combination of structurally controlled orientations and regional stress fields in which Sh is oriented NNE to NE at a moderate to high angle to the trace of the West Antarctic rift system.

2012 ARPA-E Energy Innovation Summit: Profiling Foro Energy: High Power Lasers - Long Distances (Performer Video)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moxley, John; Zediker, Mark; Chu, Steven

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These "performer videos" highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video from Foro Energy are Joel Moxley, Founder and CEO, Mark Zediker, Founder and CTO, and Paulmore » Deutch, President and COO. Steven Chu, Secretary of Energy, also appears briefly in this video to praise the accomplishment of a high powered laser that can transmit that power long distances for faster and more powerful drilling of geothermal, oil, and gas wells.« less

Kilauea volcano eruption seen from orbit

NASA Technical Reports Server (NTRS)

1993-01-01

The STS-51 crew had a clear view of the erupting Kilauea volcano during the early morning pass over the Hawaiian islands. Kilauea, on the southwest side of the island of Hawaii, has been erupting almost continuously since January, 1983. Kilauea's summit caldera, with the smaller Halemaumau crater nestled within, is highlighted in the early morning sun (just above the center of the picture). The lava flows which covered roads and subdivisions in 1983-90 can be seen as dark flows to the east (toward the upper right) of the steam plumes on this photo. The summit crater and lava flows of Mauna Loa volcano make up the left side of the photo. Features like the Volcano House and Kilauea Visitor Center on the edge of the caldera, the small subdivisions east of the summit, Ola's Rain Forest north of the summit, and agricultural land along the coast are easily identified.

The "Ethics Rupture" Summit, Fredericton, New Brunswick, Canada, October 25-28, 2012.

PubMed

van den Hoonaard, Will C

2013-02-01

This report explains the background of the "Ethics Rupture" Summit held in New Brunswick, Canada, October 2012, focusing on the disconnect between research-ethics policies and the nature and purpose of social-science research-an unintended "rupture" in ethics governance. Ethics is about human relationships, and the governance of ethics must reflect that fact rather than function as a bureaucratic, self-legitimating system of control. The themes that emerged from the Summit point to: structural problems with the current system; an undermining of the original, historical mission of some social-science disciplines; a discomfort with new methodologies; ethics committees and the well-being and education of social-science students; the possibilities of reform and renewal; and the next steps. Finally, the report refers in broad outlines to a "New Brunswick Declaration," which is currently being considered by participants of the Summit.

Environmental perceptions and objective walking trail audits inform a community-based participatory research walking intervention

PubMed Central

2012-01-01

Background Given the documented physical activity disparities that exist among low-income minority communities and the increased focused on socio-ecological approaches to address physical inactivity, efforts aimed at understanding the built environment to support physical activity are needed. This community-based participatory research (CBPR) project investigates walking trails perceptions in a high minority southern community and objectively examines walking trails. The primary aim is to explore if perceived and objective audit variables predict meeting recommendations for walking and physical activity, MET/minutes/week of physical activity, and frequency of trail use. Methods A proportional sampling plan was used to survey community residents in this cross-sectional study. Previously validated instruments were pilot tested and appropriately adapted and included the short version of the validated International Physical Activity Questionnaire, trail use, and perceptions of walking trails. Walking trails were assessed using the valid and reliable Path Environmental Audit Tool which assesses four content areas including: design features, amenities, maintenance, and pedestrian safety from traffic. Analyses included Chi-square, one-way ANOVA's, multiple linear regression, and multiple logistic models. Results Numerous (n = 21) high quality walking trails were available. Across trails, there were very few indicators of incivilities and safety features rated relatively high. Among the 372 respondents, trail use significantly predicted meeting recommendations for walking and physical activity, and MET/minutes/week. While controlling for other variables, significant predictors of trail use included proximity to trails, as well as perceptions of walking trail safety, trail amenities, and neighborhood pedestrian safety. Furthermore, while controlling for education, gender, and income; for every one time per week increase in using walking trails, the odds for meeting walking recommendations increased 1.27 times, and the odds for meeting PA recommendation increased 3.54 times. Perceived and objective audit variables did not predict meeting physical activity recommendations. Conclusions To improve physical activity levels, intervention efforts are needed to maximize the use of existing trails, as well as improve residents' perceptions related to incivilities, safety, conditions of trail, and amenities of the walking trails. This study provides important insights for informing development of the CBPR walking intervention and informing local recreational and environmental policies in this southern community. PMID:22289653

Comparing the impacts of hiking, skiing and horse riding on trail and vegetation in different types of forest.

PubMed

Törn, A; Tolvanen, A; Norokorpi, Y; Tervo, R; Siikamäki, P

2009-03-01

Nature-based tourism in protected areas has increased and diversified dramatically during the last decades. Different recreational activities have a range of impacts on natural environments. This paper reports results from a comparison of the impacts of hiking, cross-country skiing and horse riding on trail characteristics and vegetation in northern Finland. Widths and depths of existing trails, and vegetation on trails and in the neighbouring forests were monitored in two research sites during 2001 and 2002. Trail characteristics and vegetation were clearly related to the recreational activity, research site and forest type. Horse trails were as deep as hiking trails, even though the annual number of users was 150-fold higher on the hiking trails. Simultaneously, cross-country skiing had the least effect on trails due to the protective snow cover during winter. Hiking trail plots had little or no vegetation cover, horse riding trail plots had lower vegetation cover than forest plots, while skiing had no impact on total vegetation cover. On the other hand, on horse riding trails there were more forbs and grasses, many of which did not grow naturally in the forest. These species that were limited to riding trails may change the structure of adjacent plant communities in the long run. Therefore, the type of activities undertaken and the sensitivity of habitats to these activities should be a major consideration in the planning and management of nature-based tourism. Establishment of artificial structures, such as stairs, duckboards and trail cover, or complete closure of the site, may be the only way to protect the most sensitive or deteriorated sites.

Assessing and Predicting Erosion from Off Highway Vehicle Trails in Front-Range Rocky Mountain Watersheds.

NASA Astrophysics Data System (ADS)

Howard, M. J.; Silins, U.; Anderson, A.

2016-12-01

Off highway vehicle (OHV) trails have the potential to deliver sediment to sensitive headwater streams and increased OHV use is a growing watershed management concern in many Rocky Mountain regions. Predictive tools for estimating erosion and sediment inputs are needed to support assessment and management of erosion from OHV trail networks. The objective of this study was to a) assess erodibility (K factor) and total erosion from OHV trail networks in Rocky Mountain watersheds in south-west Alberta, Canada, and to b) evaluate the applicability of the Universal Soil Loss Equation (USLE) for predicting OHV trail erosion to support erosion management strategies. Measured erosion rates and erodibility (K) from rainfall simulation plots on OHV trails during the summers of 2014 and 2015 were compared to USLE predicted erosion from these same trails. Measured erodibility (K) from 23 rainfall simulation plots was highly variable (0.001-0.273 Mg*ha*hr/ha*MJ*mm) as was total seasonal erosion from 52 large trail sections (0.0595-43.3 Mg/ha) across trail segments of variable slope, stoniness, and trail use intensity. In particular, intensity of trail use had a large effect on both erodibility and total erosion that is not presently captured by erodibility indices (K) derived from soil characteristics. Results of this study suggest that while application of USLE for predicting erosion from OHV trail networks may be useful for initial coarse erosion assessment, a better understanding of the effect of factors such as road/trail use intensity on erodibility is needed to support use of USLE or associated erosion prediction tools for road/trail erosion management.

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Signaling and Cell Death in the Immature Central Nervous System after Hypoxia-Ischemia and Inflammation*

PubMed Central

Kichev, Anton; Rousset, Catherine I.; Baburamani, Ana A.; Levison, Steven W.; Wood, Teresa L.; Gressens, Pierre; Thornton, Claire; Hagberg, Henrik

2014-01-01

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family. The interaction of TRAIL with death receptor 4 (DR4) and DR5 can trigger apoptotic cell death. The aim of this study was to investigate the role of TRAIL signaling in neonatal hypoxia-ischemia (HI). Using a neonatal mouse model of HI, mRNA, and protein expression of TRAIL, DR5 and the TRAIL decoy receptors osteoprotegerin (OPG), mDcTRAILR1, and mDcTRAILR2 were determined. In vitro, mRNA expression of these genes was measured in primary neurons and oligodendrocyte progenitor cells (OPCs) after inflammatory cytokine (TNF-α/IFN-γ) treatment and/or oxygen and glucose deprivation (OGD). The toxicity of these various paradigms was also measured. The expression of TRAIL, DR5, OPG, and mDcTRAILR2 was significantly increased after HI. In vitro, inflammatory cytokines and OGD treatment significantly induced mRNAs for TRAIL, DR5, OPG, and mDcTRAILR2 in primary neurons and of TRAIL and OPG in OPCs. TRAIL protein was expressed primarily in microglia and astroglia, whereas DR5 co-localized with neurons and OPCs in vivo. OGD enhanced TNF-α/IFN-γ toxicity in both neuronal and OPC cultures. Recombinant TRAIL exerted toxicity alone or in combination with OGD and TNF-α/IFN-γ in primary neurons but not in OPC cultures. The marked increases in the expression of TRAIL and its receptors after cytokine exposure and OGD in primary neurons and OPCs were similar to those found in our animal model of neonatal HI. The toxicity of TRAIL in primary neurons suggests that TRAIL signaling participates in neonatal brain injury after inflammation and HI. PMID:24509861

Novel targets for sensitizing breast cancer cells to TRAIL-induced apoptosis with siRNA delivery.

PubMed

Thapa, Bindu; Bahadur Kc, Remant; Uludağ, Hasan

2018-02-01

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL that can aid in therapy, protein targets whose silencing sensitized breast cancer cells against TRAIL were screened with an siRNA library against 446 human apoptosis-related proteins in MDA-231 cells. Using a cationic lipopolymer (PEI-αLA) for delivery of library members, 16 siRNAs were identified that sensitized the TRAIL-induced death in MDA-231 cells. The siRNAs targeting BCL2L12 and SOD1 were further evaluated based on the novelty and their ability to sensitize TRAIL induced cell death. Silencing both targets sensitized TRAIL-mediated cell death in MDA-231 cells as well as TRAIL resistant breast cancer cells, MCF-7. Combination of TRAIL and siRNA silencing BCL2L12 had no effect in normal human umbilical vein cells and human bone marrow stromal cell. The silencing of BCL2L12 and SOD1 enhanced TRAIL-mediated apoptosis in MDA-231 cells via synergistically activating capsase-3 activity. Hence, here we report siRNAs targeting BCL2L12 and SOD1 as a novel regulator of TRAIL-induced cell death in breast cancer cells, providing a new approach for enhancing TRAIL therapy for breast cancer. The combination of siRNA targeting BCL2L12 and TRAIL can be a highly effective synergistic pair in breast cancer cells with minimal effect on the non-transformed cells. © 2017 UICC.

Recreational trails reduce the density of ground-dwelling birds in protected areas.

PubMed

Thompson, Bill

2015-05-01

Recreational disturbance associated with trails has been identified as one of the major factors causing a decline of native biodiversity within protected areas. However, despite the negative impacts that recreation can have on biodiversity, providing public access to nature is critical for the future of the conservation of biodiversity. As such, many protected area managers are looking for tools to help maintain a balance between public access and biodiversity conservation. The objectives of this study were to examine the impacts of recreational trails on forest-dwelling bird communities in eastern North America, identify functional guilds which are particularly sensitive to recreational trails, and derive guidelines for trail design to assist in managing the impacts of recreational trails on forest-dwelling birds. Trails within 24 publicly owned natural areas were mapped, and breeding bird communities were described with the use of point count surveys. The density of forest birds, particularly of those species which nest or forage on the ground, were significantly positively influenced by the amount of trail-free refuge habitat. Although management options to control trail use in non-staffed protected areas are limited, this study suggests that protected area managers could design and maintain a trail network that would minimize impacts on resident wildlife, while providing recreational opportunities for visitors, by designing their trail network to maximize the area of trail-free habitat.

Multiple effects of TRAIL in human carcinoma cells: Induction of apoptosis, senescence, proliferation, and cytokine production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levina, Vera; Marrangoni, Adele M.; DeMarco, Richard

TRAIL is a death ligand that induces apoptosis in malignant but not normal cells. Recently the ability of TRAIL to induce proliferation in apoptosis-resistant normal and malignant cells was reported. In this study, we analyzed TRAIL effects in apoptosis sensitive MCF7, OVCAR3 and H460 human tumor cell lines. TRAIL at low concentrations preferentially induced cell proliferation. At 100 ng/ml, apoptotic death was readily observed, however surviving cells acquired higher proliferative capacity. TRAIL-stimulated production of several cytokines, IL-8, RANTES, MCP-1 and bFGF, and activation of caspases 1 and 8 was essential for this effect. Antibodies to IL-8, RANTES, and bFGF blockedmore » TRAIL-induced cell proliferation and further stimulated apoptosis. For the first time, we report that high TRAIL concentrations induced cell senescence as determined by the altered morphology and expression of several senescence markers: SA-{beta}-gal, p21{sup Waf1/Cip1}, p16{sup INK4a}, and HMGA. Caspase 9 inhibition protected TRAIL-treated cells from senescence, whereas inhibition of caspases 1 and 8 increased the yield of SLP cells. In conclusion, in cultured human carcinoma cells, TRAIL therapy results in three functional outcomes, apoptosis, proliferation and senescence. TRAIL-induced proapoptotic and prosurvival responses correlate with the strength of signaling. TRAIL-induced cytokine production is responsible for its proliferative and prosurvival effects.« less

Recreational Trails Reduce the Density of Ground-Dwelling Birds in Protected Areas

NASA Astrophysics Data System (ADS)

Thompson, Bill

2015-05-01

Recreational disturbance associated with trails has been identified as one of the major factors causing a decline of native biodiversity within protected areas. However, despite the negative impacts that recreation can have on biodiversity, providing public access to nature is critical for the future of the conservation of biodiversity. As such, many protected area managers are looking for tools to help maintain a balance between public access and biodiversity conservation. The objectives of this study were to examine the impacts of recreational trails on forest-dwelling bird communities in eastern North America, identify functional guilds which are particularly sensitive to recreational trails, and derive guidelines for trail design to assist in managing the impacts of recreational trails on forest-dwelling birds. Trails within 24 publicly owned natural areas were mapped, and breeding bird communities were described with the use of point count surveys. The density of forest birds, particularly of those species which nest or forage on the ground, were significantly positively influenced by the amount of trail-free refuge habitat. Although management options to control trail use in non-staffed protected areas are limited, this study suggests that protected area managers could design and maintain a trail network that would minimize impacts on resident wildlife, while providing recreational opportunities for visitors, by designing their trail network to maximize the area of trail-free habitat.

Rock Levitation by Water and Ice; an Explanation for Trails in Racetrack Playa, California

NASA Astrophysics Data System (ADS)

Kletetschka, G.; Ryan, A.; McKinney, E.; Fercana, G.; Schwebler, K. P.; McIntire, L.; Miller, D.; Fox, V. K.; Marbourg, J. M.; Naquin, C. A.; Krzykowski, M.; Wilde, J. R.; Kopp, E. S.; Romine, G.; Yawn, K.; Schoch, I.; McAdam, M.; Burger, D.; Rilee, K.; Jackson, B. K.; Parsons, A. M.; Cheung, C. Y.; Lunar; Planetary Science Academy

2010-12-01

Through a process that is nearly a century-old mystery, rock fragments race over a desiccated layer of sediment in the California desert, forming the infamous rock trails of the Racetrack playa, found in Death Valley, California. Rocks, randomly distributed over the playa, have indented grooves or trails next to them, appearing as if someone had dragged them over the playa surface when wet. Interestingly, no one has ever witnessed the movement of these rocks. Furthermore, the mechanism responsible for these trails behind the rocks has not yet been explained. Rocks have masses ranging from 0.5 kg to 300 kg, and the trails have a chaotic character, with some trails as long as 1/2 km. Each rock has a mound of raised clay on one side and a mud trail on the other; no other unusual marks are visible. A number of trails have no rocks at the end, with only a mound of solid clay where a rock once appeared to be, as if something was pushing the clay forwards to make the trail but disappeared after the trail was made. Measurements of the humidity and temperature of the sediment pointed towards a unique mechanism of how the trails could form on their own and how simple environmental changes could result in the aforementioned trails in the sediment.

Investigating the Source Mechanisms of Deflation-Inflation Events at Kilauea Volcano, Hawai`i

NASA Astrophysics Data System (ADS)

Johnson, J. H.; Anderson, K. R.; Poland, M. P.; Miklius, A.

2012-12-01

At Kilauea Volcano, Hawai`i, cyclic deflation-inflation ("DI") events have been observed on tiltmeters since 1988. Most DI events begin with deflation at the summit that generally lasts 12-72 hours and accumulate ~1-5 microradians of tilt as measured on the rim of Kilauea Caldera, followed by inflation that is initially rapid but wanes over the course of 12-48 hours as the net deformation approaches pre-event levels. This gives the tilt events a V- or U-shaped appearance in the tilt time series, depending on the onset deflation rates. DI events are also manifested at the Pu`u `O`o eruptive vent on Kilauea's east rift zone, about 20 km along the rift from the summit, and lag summit deformation by approximately 30-90 minutes (except during 2005-2007, when summit DI events were not detected at Pu`u `O`o). The temporal correlation of tilt at the caldera and east rift zone indicates that these events affect much of Kilauea's magma plumbing system, from the summit magma reservoir to the eruption site. Large-magnitude DI events are visible in data from continuously-recording GPS stations both at Kilauea's summit and at Pu`u `O`o, and some DI events have been imaged using InSAR. Tilt events with long-lived (several days) deflation phases are usually associated with decreases in lava effusion or even eruptive pauses on the east rift zone, while large inflationary phases are often accompanied by surges in lava effusion, new breakouts, and thus increased lava flow hazard. The lava level within the summit eruptive vent, which has been continuously visible since early 2010, correlates with tilt deformation associated with DI events. Seismic tremor levels measured at Kilauea summit at times also display a relation with DI events, sometimes correlated and sometimes anti-correlated. Tilt events have become more common since the onset of Kilauea's summit eruption in March 2008, increasing from about 5-10 per year before 2008 to more than 80 in the 8 months of 2012. Two possibly inter-related mechanisms have been suggested to explain the DI events: (1) blockage and subsequent clearing of the transport pathway that feeds the shallow summit magma system and conduit to Pu`u `O`o, and (2) convective overturns caused by replacement of degassed magma with gas-rich magma. Using a simple kinematic forward model, we invert deformation data from more than 400 DI events to estimate the location and volume change of the shallow summit source generating the ground tilt, and look for changes associated with the evolution of eruptive behaviour at Kilauea. More insight into the DI events can be gained by developing a physics-based model capable of linking magmatic processes with the temporal evolution of individual DI events. We will construct multiphysics finite element models (FEMs) to simulate deformation caused by the two proposed mechanisms to link the observations to the physical processes that drive DI events. The FEMs allow us to investigate complicated model configurations that account for 3D geometric configurations, distributions of rheologic properties, and multiple deformation sources. Crucially, the models also allow for temporal variation of fluid flow and subsurface pressurization, which will provide insights into the unique patterns of tilt observed at Kilauea.

The clinical academic workforce in Australia and New Zealand: report on the second binational summit to implement a sustainable training pathway.

PubMed

Windsor, John; Garrod, Tamsin; Talley, Nicholas J; Tebbutt, Carmel; Churchill, James; Farmer, Elizabeth; Baur, Louise; Smith, Julian A

2017-04-01

There has been a decline in the proportion of clinical academics compared with full-time clinicians, since 2004. A Working Party was established to help develop and implement a model for the training of clinical academics. After a highly successful first summit in 2014 that summarised the challenges faced by clinical academics in Australia and New Zealand, a second summit was convened late in 2015 to report on progress and to identify key areas for further action. The second summit provided survey results that identified the varied training pathways currently offered to clinical academics and the institutions willing to be involved in developing improved pathways. A literature review also described the contributions that clinical academics make to the health sector and the challenges faced by this workforce sector. Current training pathways created for clinical academics by Australasian institutions were presented as examples of what can be done. The perspectives of government and research organisations presented at the summit helped define how key stakeholders can contribute. Following the summit, there was a strong commitment to continue to work towards developing a sustainable and defined training pathway for clinical academics. The need for a coordinated and integrated approach was highlighted. Some key objectives were agreed upon for the next phase, including identifying and engaging key advocates within government and leading institutions; publishing and profiling the contributions of successful clinical academics to healthcare outcomes; defining the stages of a clinical academic training pathway; and establishing a mentoring programme for training clinical academics. © 2017 Royal Australasian College of Physicians.

Hikers and other trail users

Treesearch

Robert C. Lucas

1971-01-01

Trail users seem neglected. Trail systems are limited, largely relics of fire control rather than designed for recreation; and total trail miles are probably declining. On the other hand, participation in various kinds of trail-oriented recreation is substantial and growing. Most activity is for short periods of time close to participants' homes. A varied and...

75 FR 37462 - Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

... DEPARTMENT OF THE INTERIOR National Park Service Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail AGENCY: National Parks Service, Interior. ACTION: Official Insignia, Designation. Authority: National Trails System Act, 16 U.S.C. 124(a) and 1246(c) and Protection of Official...

76 FR 26767 - Captain John Smith Chesapeake National Historic Trail Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-09

... Trail Advisory Council AGENCY: National Park Service, Interior. ACTION: Notice of meeting. SUMMARY: As... that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will hold a meeting. Designated through an amendment to the National Trails System Act (16 U.S.C. 1241), the trail...

76 FR 52691 - Captain John Smith Chesapeake National Historic Trail Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-23

... Trail Advisory Council AGENCY: National Park Service, Interior. ACTION: Notice of meeting. SUMMARY: As... that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will hold a meeting. Designated through an amendment to the National Trails System Act (16 U.S.C. 1241), the trail...

36 CFR 13.1308 - Harding Icefield Trail.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Harding Icefield Trail. 13... Provisions § 13.1308 Harding Icefield Trail. The Harding Icefield Trail from the junction with the main paved trail near Exit Glacier to the emergency hut near the terminus is closed to— (a) Camping within 1/8 mile...

30 CFR 77.605 - Breaking trailing cable and power cable connections.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

30 CFR 75.828 - Trailing cable pulling.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cable pulling. 75.828 Section 75.828... Longwalls § 75.828 Trailing cable pulling. The trailing cable must be de-energized prior to being pulled by... procedures must be followed when pulling the trailing cable with equipment other than the continuous mining...

30 CFR 77.601 - Trailing cables or portable cables; temporary splices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cables or portable cables; temporary... OF UNDERGROUND COAL MINES Trailing Cables § 77.601 Trailing cables or portable cables; temporary splices. Temporary splices in trailing cables or portable cables shall be made in a workmanlike manner and...

36 CFR 261.55 - National Forest System trails.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false National Forest System trails... PROHIBITIONS Prohibitions in Areas Designated by Order § 261.55 National Forest System trails. When provided by... National Forest System trail: (a) Being on a trail. (b) Using any type of vehicle prohibited by the order...

76 FR 8992 - National Trails System Act and Railroad Rights-of-Way

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-16

...] National Trails System Act and Railroad Rights-of-Way AGENCY: Surface Transportation Board, DOT. ACTION... procedures regarding the use of railroad rights-of-way for railbanking and interim trail use under the National Trails System Act (Trails Act). DATES: Comments are due by April 12, 2011; replies are due by May...

77 FR 33206 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

...: ER12-1848-000. Applicants: High Trail Wind Farm, LLC. Description: High Trail Wind Farm, LLC submits tariff filing per 35: High Trail Wind Farm First Revised MBR to be effective 5/26/2012. Filed Date: 5/25...-000. Applicants: Old Trail Wind Farm, LLC. Description: Old Trail Wind Farm, LLC submits tariff filing...

30 CFR 77.605 - Breaking trailing cable and power cable connections.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

30 CFR 77.605 - Breaking trailing cable and power cable connections.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

30 CFR 77.605 - Breaking trailing cable and power cable connections.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

30 CFR 77.605 - Breaking trailing cable and power cable connections.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

Assessing soil erosion on trails: A comparison of techniques

Treesearch

Mark C. Jewell; William E. Hammitt

2000-01-01

Reports of trail degradation have been increasing in different wildernesses. This impact has become a common concern among managers. Deteriorating tread conditions of trails are increasing, as is concern at protected areas worldwide. In order to make objective and timely trail resource decisions, managers need to have effective and efficient methods of assessing trail...

National recreation trails: an overview

Treesearch

Joanne F. Tynon; James A. Harding; Deborah J. Chavez

1998-01-01

Since the establishment of the National Trails System in 1968, 822 trails have been designated as National Recreation Trails (NRT). These trails support a wide range of activities, including but not limited to hiking, mountain biking, cross country skiing and horseback riding. In short, NRTs can be found across a diversity of geographic settings and are frequent...

Trail-following responses of the Argentine ant,Iridomyrmex humilis (Mayr), to a synthetic trail pheromone component and analogs.

PubMed

Van Vorhis Key, S E; Baker, T C

1982-01-01

Behavioral evidence indicates that (Z)-9-hexadecenal (Z9-16∶ALD) is a trail pheromone component ofIridomyrmex humilis, and that the true trail pheromone may be multicomponent. Trail-following responses ofI. humilis workers to several concentrations of syntheticZ9-16∶ALD, a constituent of the Pavan's gland, were found to be comparable to responses to gaster extract trails containing ca. 100 times lessZ9-16∶ALD. Of the five aldehyde analogs tested, only (Z)-7-hexadecenal (Z7-16∶ALD) elicited significant trail-following. However, following responses to severalZ9-16∶ALD-Z7-16∶ALD combinations were lower than responses toZ9-16∶ALD alone. Trails on filter paper of biologically relevant concentrations ofZ9-16∶ALD lose activity within 2 hr in the laboratory. The release rate ofZ9-16∶ALD measured from filter paper trails was 0.25 ± 0.10 pg/cm-sec. This was used to estimate the trail-following threshold for this compound of Argentine ant workers.

Assessing the influence of sustainable trail design and maintenance on soil loss.

PubMed

Marion, Jeffrey L; Wimpey, Jeremy

2017-03-15

Natural-surfaced trail systems are an important infrastructure component providing a means for accessing remote protected natural area destinations. The condition and usability of trails is a critical concern of land managers charged with providing recreational access while preserving natural conditions, and to visitors seeking high quality recreational opportunities and experiences. While an adequate number of trail management publications provide prescriptive guidance for designing, constructing, and maintaining natural-surfaced trails, surprisingly little research has been directed at providing a scientific basis for this guidance. Results from a review of the literature and three scientific studies are presented to model and clarify the influence of factors that substantially influence trail soil loss and that can be manipulated by trail professionals to sustain high traffic while minimizing soil loss over time. Key factors include trail grade, slope alignment angle, tread drainage features, and the amount of rock in tread substrates. A new Trail Sustainability Rating is developed and offered as a tool for evaluating or improving the sustainability of existing or new trails. Published by Elsevier Ltd.

Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

PubMed Central

Iurlaro, Raffaella; Püschel, Franziska; León-Annicchiarico, Clara Lucía; O'Connor, Hazel; Martin, Seamus J.; Palou-Gramón, Daniel; Lucendo, Estefanía

2017-01-01

ABSTRACT Metabolic stress occurs frequently in tumors and in normal tissues undergoing transient ischemia. Nutrient deprivation triggers, among many potential cell death-inducing pathways, an endoplasmic reticulum (ER) stress response with the induction of the integrated stress response transcription factor ATF4. However, how this results in cell death remains unknown. Here we show that glucose deprivation triggered ER stress and induced the unfolded protein response transcription factors ATF4 and CHOP. This was associated with the nontranscriptional accumulation of TRAIL receptor 1 (TRAIL-R1) (DR4) and with the ATF4-mediated, CHOP-independent induction of TRAIL-R2 (DR5), suggesting that cell death in this context may involve death receptor signaling. Consistent with this, the ablation of TRAIL-R1, TRAIL-R2, FADD, Bid, and caspase-8 attenuated cell death, although the downregulation of TRAIL did not, suggesting ligand-independent activation of TRAIL receptors. These data indicate that stress triggered by glucose deprivation promotes the ATF4-dependent upregulation of TRAIL-R2/DR5 and TRAIL receptor-mediated cell death. PMID:28242652

Influence of TRAIL gene on biomechanical properties of the human leukemic cell line Jurkat.

PubMed

Yao, Weijuan; Chen, Kai; Wang, Xinjuan; Xie, Lide; Wen, Zongyao; Yan, Zongyi; Chien, Shu

2002-12-01

We cloned the cDNA fragment of human TNF-related apoptosis inducing ligand (TRAIL) into RevTet-On, a Tet-regulated and high-level gene expression system. Making use of the TRAIL gene expression system in Jurkat as a cell model, we studied the influence of TRAIL gene on the biomechanics properties of Jurkat through measuring changes of cellular biomechanics properties before and after the TRAIL gene expression, which was induced by adding tetracycline derivative doxycycline (Dox). The results indicated that the TRAIL gene expression led to significant changes in cellular biomechanics properties. The osmotic fragility increased and the cell stiffness increased after the expression of TRAIL gene. Thus, the apoptosis-inducing TRAIL gene caused significant changes in the biomechanics properties of Jurkat cells.

International Summit on Integrated Environmental Modeling

EPA Science Inventory

This report describes the International Summit on Integrated Environmental Modeling (IEM), held in Washington, DC 7th-9th December 2010. The meeting brought together 57 scientists and managers from leading US and European government and non-governmental organizations, universitie...

18 CFR 1304.6 - Appeals.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Drive, Knoxville, Tennessee 37902. Otherwise, the initial decision of the Vice President's designee... W. Summit Hill Drive, Knoxville, Tennessee 37902. Otherwise, the Vice President's decision becomes..., Tennessee Valley Authority, 400 West Summit Hill Drive, Knoxville, Tennessee 37902. If within 60 days of...

2013 Summit on Reducing Exposure to Dust from Treated Seed

EPA Pesticide Factsheets

The Pollinator Summit was part of EPA's ongoing collaboration with stakeholders to manage pesticide risks to bees. Focus: how to protect bees from unintended pesticide exposure, esp. dust in agricultural planting operations using pesticide-coated seeds.

NASA Education Stakeholder's Summit

NASA Image and Video Library

2010-09-12

James Stofan, right, NASA Acting Associate Administrator for Education, introduces the keynote speakers at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

NASA Education Stakeholder's Summit

NASA Image and Video Library

2010-09-12

Cora B. Marrett, right, PhD, Acting Director, National Science Foundation gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

NASA Education Stakeholder's Summit

NASA Image and Video Library

2010-09-12

Cora B. Marrett, PhD, Acting Director, National Science Foundation gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

29. ROAD TO SUMMIT SHOWING VISITOR OVERLOOK AND SCIENCE CITY, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. ROAD TO SUMMIT SHOWING VISITOR OVERLOOK AND SCIENCE CITY, FROM ATOP WHITE HILL. NOTE THE ARCHAEOLOGICAL REMAINS OF WHAT APPEARS TO BE A CIRCULAR SHELTER AT LOWER RIGHT. - Haleakala National Park Roads, Pukalani, Maui County, HI

3. ROAD TO SUMMIT SHOWING VISITOR OVERLOOK AND SCIENCE CITY, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. ROAD TO SUMMIT SHOWING VISITOR OVERLOOK AND SCIENCE CITY, FROM ATOP WHITE HILL. NOTE THE ARCHAEOLOGICAL REMAINS OF WHAT APPEARS TO BE A CIRCULAR SHELTER AT LOWER RIGHT. - Haleakala National Park Roads, Pukalani, Maui County, HI

The influence of use-related, environmental, and managerial factors on soil loss from recreational trails.

PubMed

Olive, Nathaniel D; Marion, Jeffrey L

2009-03-01

Recreational uses of unsurfaced trails inevitably result in their degradation, with the type and extent of resource impact influenced by factors such as soil texture, topography, climate, trail design and maintenance, and type and amount of use. Of particular concern, the loss of soil through erosion is generally considered a significant and irreversible form of trail impact. This research investigated the influence of several use-related, environmental, and managerial factors on soil loss on recreational trails and roads at Big South Fork National River and Recreation Area, a unit of the U.S. National Park Service. Regression modeling revealed that trail position, trail slope alignment angle, grade, water drainage, and type of use are significant determinants of soil loss. The introduction of individual and groups of variables into a series of regression models provides improved understanding and insights regarding the relative influence of these variables, informing the selection of more effective trail management actions. Study results suggest that trail erosion can be minimized by avoiding "fall-line" alignments, steep grades, and valley-bottom alignments near streams, installing and maintaining adequate densities of tread drainage features, applying gravel to harden treads, and reducing horse and all-terrain vehicle use or restricting them to more resistant routes. This research also sought to develop a more efficient Variable Cross-Sectional Area method for assessing soil loss on trails. This method permitted incorporation of CSA measures in a representative sampling scheme applied to a large (24%) sample of the park's 526 km trail system. The variety of soil loss measures derived from the Variable CSA method, including extrapolated trail-wide soil loss estimates, permit an objective quantification of soil erosion on recreational trails and roads. Such data support relational analyses to increase understanding of trail degradation, and long-term monitoring of the natural and recreational integrity of the trail system infrastructure.

The influence of use-related, environmental, and managerial factors on soil loss from recreational trails

USGS Publications Warehouse

Olive, Nathaniel D.; Marion, Jeffrey L.

2009-01-01

Recreational uses of unsurfaced trails inevitably result in their degradation, with the type and extent of resource impact influenced by factors such as soil texture, topography, climate, trail design and maintenance, and type and amount of use. Of particular concern, the loss of soil through erosion is generally considered a significant and irreversible form of trail impact. This research investigated the influence of several use-related, environmental, and managerial factors on soil loss on recreational trails and roads at Big South Fork National River and Recreation Area, a unit of the U.S. National Park Service. Regression modeling revealed that trail position, trail slope alignment angle, grade, water drainage, and type of use are significant determinants of soil loss. The introduction of individual and groups of variables into a series of regression models provides improved understanding and insights regarding the relative influence of these variables, informing the selection of more effective trail management actions. Study results suggest that trail erosion can be minimized by avoiding “fall-line” alignments, steep grades, and valley-bottom alignments near streams, installing and maintaining adequate densities of tread drainage features, applying gravel to harden treads, and reducing horse and all-terrain vehicle use or restricting them to more resistant routes.This research also sought to develop a more efficient Variable Cross-Sectional Area method for assessing soil loss on trails. This method permitted incorporation of CSA measures in a representative sampling scheme applied to a large (24%) sample of the park's 526 km trail system. The variety of soil loss measures derived from the Variable CSA method, including extrapolated trail-wide soil loss estimates, permit an objective quantification of soil erosion on recreational trails and roads. Such data support relational analyses to increase understanding of trail degradation, and long-term monitoring of the natural and recreational integrity of the trail system infrastructure.

The Influence of Snowmobile Trails on Coyote Movements during Winter in High-Elevation Landscapes

PubMed Central

Gese, Eric M.; Dowd, Jennifer L. B.; Aubry, Lise M.

2013-01-01

Competition between sympatric carnivores has long been of interest to ecologists. Increased understanding of these interactions can be useful for conservation planning. Increased snowmobile traffic on public lands and in habitats used by Canada lynx (Lynx canadensis) remains controversial due to the concern of coyote (Canis latrans) use of snowmobile trails and potential competition with lynx. Determining the variables influencing coyote use of snowmobile trails has been a priority for managers attempting to conserve lynx and their critical habitat. During 2 winters in northwest Wyoming, we backtracked coyotes for 265 km to determine how varying snow characteristics influenced coyote movements; 278 km of random backtracking was conducted simultaneously for comparison. Despite deep snow (>1 m deep), radio-collared coyotes persisted at high elevations (>2,500 m) year-round. All coyotes used snowmobile trails for some portion of their travel. Coyotes used snowmobile trails for 35% of their travel distance (random: 13%) for a mean distance of 149 m (random: 59 m). Coyote use of snowmobile trails increased as snow depth and penetrability off trails increased. Essentially, snow characteristics were most influential on how much time coyotes spent on snowmobile trails. In the early months of winter, snow depth was low, yet the snow column remained dry and the coyotes traveled off trails. As winter progressed and snow depth increased and snow penetrability increased, coyotes spent more travel distance on snowmobile trails. As spring approached, the snow depth remained high but penetrability decreased, hence coyotes traveled less on snowmobile trails because the snow column off trail was more supportive. Additionally, coyotes traveled closer to snowmobile trails than randomly expected and selected shallower snow when traveling off trails. Coyotes also preferred using snowmobile trails to access ungulate kills. Snow compaction from winter recreation influenced coyote movements within an area containing lynx and designated lynx habitat. PMID:24367565

The influence of snowmobile trails on coyote movements during winter in high-elevation landscapes.

PubMed

Gese, Eric M; Dowd, Jennifer L B; Aubry, Lise M

2013-01-01

Competition between sympatric carnivores has long been of interest to ecologists. Increased understanding of these interactions can be useful for conservation planning. Increased snowmobile traffic on public lands and in habitats used by Canada lynx (Lynx canadensis) remains controversial due to the concern of coyote (Canis latrans) use of snowmobile trails and potential competition with lynx. Determining the variables influencing coyote use of snowmobile trails has been a priority for managers attempting to conserve lynx and their critical habitat. During 2 winters in northwest Wyoming, we backtracked coyotes for 265 km to determine how varying snow characteristics influenced coyote movements; 278 km of random backtracking was conducted simultaneously for comparison. Despite deep snow (>1 m deep), radio-collared coyotes persisted at high elevations (>2,500 m) year-round. All coyotes used snowmobile trails for some portion of their travel. Coyotes used snowmobile trails for 35% of their travel distance (random: 13%) for a mean distance of 149 m (random: 59 m). Coyote use of snowmobile trails increased as snow depth and penetrability off trails increased. Essentially, snow characteristics were most influential on how much time coyotes spent on snowmobile trails. In the early months of winter, snow depth was low, yet the snow column remained dry and the coyotes traveled off trails. As winter progressed and snow depth increased and snow penetrability increased, coyotes spent more travel distance on snowmobile trails. As spring approached, the snow depth remained high but penetrability decreased, hence coyotes traveled less on snowmobile trails because the snow column off trail was more supportive. Additionally, coyotes traveled closer to snowmobile trails than randomly expected and selected shallower snow when traveling off trails. Coyotes also preferred using snowmobile trails to access ungulate kills. Snow compaction from winter recreation influenced coyote movements within an area containing lynx and designated lynx habitat.

The Consequences of Increased Magma Supply to Kilauea Volcano, Hawai`i

NASA Astrophysics Data System (ADS)

Poland, M.; Miklius, A.; Sutton, A. J.; Orr, T.

2007-12-01

The summer of 2007 was a time of intense activity at Kilauea. By mid-2007, ~4 years of summit inflation had uplifted and extended the caldera by 30 cm and 55 cm, respectively. Lava continued to erupt from the Pu`u `O`o vent on the east rift zone (ERZ) during the inflation. On May 24, 2007, two M4+ normal-faulting earthquakes occurred on caldera-bounding faults southeast of the summit. The seismicity did not affect summit inflation, which continued until June 17 when a dike intruded the upper and middle ERZ, causing a pause in the eruption, collapse of Pu`u `O`o's floor, and a small eruption 6 km uprift of Pu`u `O`o. The inflated state of the summit, relative timing of summit deflation and east rift zone extension, and abundant co-intrusive earthquake activity suggest forcible intrusion of magma. Lava returned to Pu`u `O`o by July 2, forming a lake that gradually refilled much of the collapsed crater. Early on July 21, the lake drained suddenly, the cone began to collapse, and a 2-km-long series of discontinuous eruptive fissures opened on and beyond the east flank of Pu`u `O`o. Sesimicity in Kilauea's south flank has been elevated since June and several M3+ earthquakes have occurred there, including a M5.4 on August 13. An increase in magma supply to Kilauea's shallow magmatic system is the probable cause for the events of summer 2007. Summit inflation since 2003 occurred during a period of constant or increasing magma supply to Pu`u `O`o, based on SO2 emissions from the ERZ. The rate of inflation increased markedly in early 2006, and uplift also began in the southwest rift zone. CO2 emissions at the summit, indicative of the quantity of magma degassing beneath Kilauea's caldera, more than doubled between 2003 and 2006. Also since 2003, the ERZ immediately downrift of Pu`u `O`o extended, and subsidence in the lower ERZ ceased. Together, these factors suggest that the magma supply rate to Kilauea's shallow magmatic system (the summit and rift zones above about 5 km depth) approximately doubled between 2003 and 2006. Subsequent volcanic and earthquake activity, including the events of mid-2007, are probably a result (either directly or indirectly) of this increase.

Recent Inflation of Kilauea Volcano During the Ongoing Eruption - Harbinger of Change?

NASA Astrophysics Data System (ADS)

Miklius, A.

2005-12-01

Since the start of the Pu`u `O`o-Kupaianaha eruption on Kilauea's east rift zone in 1983, the volcano's summit has subsided over 1.5 m. Over the last two years, however, leveling and GPS networks have recorded substantial inflation of the summit magma system. Since late 2003, the summit has extended almost 20 cm and risen about 5 cm. Leveling surveys suggest that the locus of inflation has been variable, with maximum uplift shifting from an area in the caldera near Halemaumau to an area in the southeastern part of the caldera, near Keanakako`i crater. Inflation rates have also been highly variable. Starting in mid-January 2005, the inflation rate accelerated for approximately a month, with extension rates across the summit reaching over 60 cm/yr. During this accelerated inflation, on January 25, a brief inflation-deflation transient was recorded on the tiltmeter network, accompanied by volcanic tremor. This event was followed by rapid slip of Kilauea's south flank, raising intriguing possibilities about the relationship between the magmatic system and the rapid slip events. Tiltmeters at the eruption site also recorded inflation, but only until early February, when a deflationary trend began, accompanied by increased eruptive output. The summit continued to inflate until late February, deflated slightly, then resumed inflation in April. These observations suggest that the high inflation rate in January-February was a result of increased magma supply to the summit magma system. In contrast, the most recent previous episode of inflation in 2002 was related to decreased outflow at the eruption site, effectively backing up pressure in the system. That inflation episode ended with the opening of new vents on the flank of Pu`u `O`o that produced high volumes of lava. The two previous, prolonged periods of uplift at the summit were in 1985-1986, before the eruption moved downrift from Pu`u `O`o to Kupaianaha, and 1990-1992, when eruptive activity shifted back to Pu`u `O`o. The current inflation of Kilauea is likely a combination of decreased efficiency of the transport system from the summit to the eruption site and an increase in magma supply. Past behavior of the volcano suggests that such conditions favor a shift in the location of the eruptive vent.

Non-motorized winter recreation impacts to snowmelt erosion, Tronsen Basin, Eastern Cascades, Washington.

PubMed

Eagleston, Holly; Rubin, Charles

2013-01-01

Many recreation impact studies have focused on summer activities, but the environmental impact of winter recreation is poorly characterized. This study characterizes the impact of snowshoe/cross-country ski compaction and snowmelt erosion on trails. Trail cross-sectional profiles were measured before and after the winter season to map changes in erosion due to winter recreation. Compacted snow on the trail was 30 % more dense than snowpack off the trail before spring melt out. Snow stayed on the trail 7 days longer. Soil and organic material was transported after spring snowmelt with -9.5 ± 2.4 cm(2) total erosion occurring on the trail transects and -3.8 ± 2.4 cm(2) total erosion occurring on the control transect (P = 0.046). More material was transported on the trail than on the control, 12.9± 2.4 versus 6.0 ± 2.4 cm(2) (P = 0.055), however, deposition levels remained similar on the trail and on the control. Snow compaction from snowshoers and cross-country skiers intensified erosion. Trail gradient was found to be significantly correlated to net changes in material on the trail (R (2) = 0.89, ρ = -0.98, P = 0.005). This study provides a baseline, showing that non-motorized winter recreation does impact soil erosion rates but more studies are needed. Trail managers should consider mitigation such as water bars, culverts and avoiding building trails with steep gradients, in order to reduce loss of soils on trails and subsequent sedimentation of streams.

Non-motorized Winter Recreation Impacts to Snowmelt Erosion, Tronsen Basin, Eastern Cascades, Washington

NASA Astrophysics Data System (ADS)

Eagleston, Holly; Rubin, Charles

2013-01-01

Many recreation impact studies have focused on summer activities, but the environmental impact of winter recreation is poorly characterized. This study characterizes the impact of snowshoe/cross-country ski compaction and snowmelt erosion on trails. Trail cross-sectional profiles were measured before and after the winter season to map changes in erosion due to winter recreation. Compacted snow on the trail was 30 % more dense than snowpack off the trail before spring melt out. Snow stayed on the trail 7 days longer. Soil and organic material was transported after spring snowmelt with -9.5 ± 2.4 cm2 total erosion occurring on the trail transects and -3.8 ± 2.4 cm2 total erosion occurring on the control transect ( P = 0.046). More material was transported on the trail than on the control, 12.9± 2.4 versus 6.0 ± 2.4 cm2 ( P = 0.055), however, deposition levels remained similar on the trail and on the control. Snow compaction from snowshoers and cross-country skiers intensified erosion. Trail gradient was found to be significantly correlated to net changes in material on the trail ( R 2 = 0.89, ρ = -0.98, P = 0.005). This study provides a baseline, showing that non-motorized winter recreation does impact soil erosion rates but more studies are needed. Trail managers should consider mitigation such as water bars, culverts and avoiding building trails with steep gradients, in order to reduce loss of soils on trails and subsequent sedimentation of streams.

Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway.

PubMed

Allen, Joshua E; Krigsfeld, Gabriel; Patel, Luv; Mayes, Patrick A; Dicker, David T; Wu, Gen Sheng; El-Deiry, Wafik S

2015-05-01

We previously reported the identification of ONC201/TIC10, a novel small molecule inducer of the human TRAIL gene that improves efficacy-limiting properties of recombinant TRAIL and is in clinical trials in advanced cancers based on its promising safety and antitumor efficacy in several preclinical models. We performed a high throughput luciferase reporter screen using the NCI Diversity Set II to identify TRAIL-inducing compounds. Small molecule-mediated induction of TRAIL reporter activity was relatively modest and the majority of the hit compounds induced low levels of TRAIL upregulation. Among the candidate TRAIL-inducing compounds, TIC9 and ONC201/TIC10 induced sustained TRAIL upregulation and apoptosis in tumor cells in vitro and in vivo. However, ONC201/TIC10 potentiated tumor cell death while sparing normal cells, unlike TIC9, and lacked genotoxicity in normal fibroblasts. Investigating the effects of TRAIL-inducing compounds on cell signaling pathways revealed that TIC9 and ONC201/TIC10, which are the most potent inducers of cell death, exclusively activate Foxo3a through inactivation of Akt/ERK to upregulate TRAIL and its pro-apoptotic death receptor DR5. These studies reveal the selective activity of ONC201/TIC10 that led to its selection as a lead compound for this novel class of antitumor agents and suggest that ONC201/TIC10 is a unique inducer of the TRAIL pathway through its concomitant regulation of the TRAIL ligand and its death receptor DR5.

Trail Pheromone of the Argentine Ant, Linepithema humile (Mayr) (Hymenoptera: Formicidae)

PubMed Central

Choe, Dong-Hwan; Villafuerte, David B.; Tsutsui, Neil D.

2012-01-01

The Argentine ant (Linepithema humile) is recognized as one of the world's most damaging invasive species. One reason for the ecological dominance of introduced Argentine ant populations is their ability to dominate food and habitat resources through the rapid mobilization and recruitment of thousands of workers. More than 30 years ago, studies showed that (Z)-9-hexadecenal strongly attracted Argentine ant workers in a multi-choice olfactometer, suggesting that (Z)-9-hexadecenal might be the trail pheromone, or a component of a trail pheromone mixture. Since then, numerous studies have considered (Z)-9-hexadecenal as the key component of the Argentine ant trails. Here, we report the first chemical analyses of the trails laid by living Argentine ants and find that (Z)-9-hexadecenal is not present in a detectible quantity. Instead, two iridoids, dolichodial and iridomyrmecin, appear to be the primary chemical constituents of the trails. Laboratory choice tests confirmed that Argentine ants were attracted to artificial trails comprised of these two chemicals significantly more often than control trails. Although (Z)-9-hexadecenal was not detected in natural trails, supplementation of artificial dolichodial+iridomyrmecin trails with an extremely low concentraion of (Z)-9-hexadecenal did increase the efficacy of the trail-following behavior. In stark contrast with previous dogma, our study suggests that dolichodial and iridomyrmecin are major components of the Argentine ant trail pheromone. (Z)-9-hexadecenal may act in an additive manner with these iridoids, but it does not occur in detectable quantities in Argentine ant recruitment trails. PMID:23028739

An analysis of state legislation on community trails.

PubMed

Eyler, Amy; Lankford, Tina; Chriqui, Jamie; Evenson, Kelly R; Kruger, Judy; Tompkins, Nancy; Voorhees, Carolyn; Zieff, Susan; Aytur, Semra; Brownson, Ross

2010-03-01

Trails provide opportunities for recreation, transportation and activity. The purpose of this article is to describe state legislation related to community trails, to analyze legislation content, and to evaluate legislation on inclusion of evidence-informed elements. State trail legislation from 2001 to 2008 was identified using online legislative databases. An analysis of evidence-informed elements included in the legislation was conducted. These elements included: funding, liability, accessibility, connectivity, and maintenance. Of the total 991 trail bills, 516 (52.0%) were appropriations bills, of which 167 (32.2%) were enacted. We analyzed 475 (48%) nonappropriation trail bills of which 139 (29.3%) were enacted. The percentage of enactment of appropriations bills decreased over time while enactment of nonappropriations trail bills increased. Over half of the nonappropriations trail bills included at least 1 evidence-informed element, most commonly funding. Few bills contained liability, connectivity, accessibility, or maintenance. There is opportunity for providing evidence-informed information to policy-makers to potentially influence bill content. The number of bills with a funding element demonstrates that fiscal support for trails is an important policy lever that state legislatures may use to support trails. Lastly, trails should be considered in over-all state-level physical activity legislation to provide opportunities for communities to be active.

Impacts of informal trails on vegetation and soils in the highest protected area in the Southern Hemisphere.

PubMed

Barros, Agustina; Gonnet, Jorge; Pickering, Catherine

2013-09-30

There is limited recreation ecology research in South America, especially studies looking at informal trails. Impacts of informal trails formed by hikers and pack animals on vegetation and soils were assessed for the highest protected area in the Southern Hemisphere, Aconcagua Provincial Park. The number of braided trails, their width and depth were surveyed at 30 sites along the main access route to Mt Aconcagua (6962 m a.s.l.). Species composition, richness and cover were also measured on control and trail transects. A total of 3.3 ha of alpine meadows and 13.4 ha of alpine steppe were disturbed by trails. Trails through meadows resulted in greater soil loss, more exposed soil and rock and less vegetation than trails through steppe vegetation. Trampling also affected the composition of meadow and steppe vegetation with declines in sedges, herbs, grasses and shrubs on trails. These results highlight how visitor use can result in substantial cumulative damage to areas of high conservation value in the Andes. With unregulated use of trails and increasing visitation, park agencies need to limit the further spread of informal trails and improve the conservation of plant communities in Aconcagua Provincial Park and other popular parks in the region. Copyright © 2013 Elsevier Ltd. All rights reserved.

Trail impacts in Sagarmatha (Mt. Everest) National Park, Nepal: a logistic regression analysis.

PubMed

Nepal, S K

2003-09-01

A trail study was conducted in the Sagarmatha (Mt. Everest) National Park, Nepal, during 1997-1998. Based on that study, this paper examines the spatial variability of trail conditions and analyzes factors that influence trail conditions. Logistic regression (multinomial logit model) is applied to examine the influence of use and environmental factors on trail conditions. The assessment of trail conditions is based on a four-class rating system: (class I, very little damaged; class II, moderately damaged, class III, heavily damaged; and class IV, severely damaged). Wald statistics and a model classification table have been used for data interpretation. Results indicate that altitude, trail gradient, hazard potential, and vegetation type are positively associated with trail condition. Trails are more degraded at higher altitude, on steep gradients, in areas with natural hazard potential, and within shrub/grassland zones. Strong correlations between high levels of trail degradation and higher frequencies of visitors and lodges were found. A detailed analysis of environmental and use factors could provide valuable information to park managers in their decisions about trail design, layout and maintenance, and efficient and effective visitor management strategies. Comparable studies on high alpine environments are needed to predict precisely the effects of topographic and climatic extremes. More refined approaches and experimental methods are necessary to control the effects of environmental factors.

Foraging ants trade off further for faster: use of natural bridges and trunk trail permanency in carpenter ants

NASA Astrophysics Data System (ADS)

Loreto, Raquel G.; Hart, Adam G.; Pereira, Thairine M.; Freitas, Mayara L. R.; Hughes, David P.; Elliot, Simon L.

2013-10-01

Trail-making ants lay pheromones on the substrate to define paths between foraging areas and the nest. Combined with the chemistry of these pheromone trails and the physics of evaporation, trail-laying and trail-following behaviours provide ant colonies with the quickest routes to food. In relatively uniform environments, such as that provided in many laboratory studies of trail-making ants, the quickest route is also often the shortest route. Here, we show that carpenter ants ( Camponotus rufipes), in natural conditions, are able to make use of apparent obstacles in their environment to assist in finding the fastest routes to food. These ants make extensive use of fallen branches, twigs and lianas as bridges to build their trails. These bridges make trails significantly longer than their straight line equivalents across the forest floor, but we estimate that ants spend less than half the time to reach the same point, due to increased carriage speed across the bridges. We also found that these trails, mainly composed of bridges, are maintained for months, so they can be characterized as trunk trails. We suggest that pheromone-based foraging trail networks in field conditions are likely to be structured by a range of potentially complex factors but that even then, speed remains the most important consideration.

Facile one-pot formulation of TRAIL-embedded paclitaxel-bound albumin nanoparticles for the treatment of pancreatic cancer.

PubMed

Min, Sun Young; Byeon, Hyeong Jun; Lee, Changkyu; Seo, Jisoo; Lee, Eun Seong; Shin, Beom Soo; Choi, Han-Gon; Lee, Kang Choon; Youn, Yu Seok

2015-10-15

Nanoparticle albumin-bound (nab™) technology is an effective way of delivering hydrophobic chemotherapeutics. We developed a one-pot/one-step formulation of paclitaxel (PTX)-bound albumin nanoparticles with embedded tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/PTX HSA-NP) for the treatment of pancreatic cancer. TRAIL/PTX HSA-NPs were fabricated using a high-pressure homogenizer at a TRAIL feeding ratio of 0.2%, 1.0%, and 2.0%. TRAIL/PTX HSA-NPs were spherical and became larger in size (170-230 nm) with increasing TRAIL amount (0.2-2.0%). The loading efficiencies of PTX were in the range of ∼86.4% and significantly low at 2.0% TRAIL (60.4%). Specifically, the inhibitory concentrations (IC50) of TRAIL (1.0 or 2.0%)/PTX HSA-NPs were >20-fold lower than that of plain PTX-HSA NP (0.032±0.06, 0.022±0.005, and 0.96±0.15 ng/ml, respectively) in pancreatic Mia Paca-2 cells. Considering TRAIL loading, bioactivity, and particle size, TRAIL(1.0%)/PTX HSA-NPs were determined as the optimal candidate for further studies. TRAIL(1.0%)/PTX HSA-NPs displayed substantially greater apoptotic activity than plain PTX HSA-NP in both FACS and TUNEL analysis. The loaded PTX and TRAIL were gradually released from the TRAIL(1.0%)/PTX HSA-NPs until ∼24 h, which is considered to be a sufficient time for delivery to the tumor tissue. TRAIL(1.0%)/PTX HSA-NP displayed markedly more antitumor efficacy than plain PTX HSA-NP in Mia Paca-2 cell-xenografted mice in terms of tumor volume (size) and weight (213.9 mm(3) and 0.18 g vs. 1126.8 mm(3) and 0.80 g, respectively). These improved in vitro and in vivo performances were due to the combined synergistic effects of PTX and TRAIL. We believe that this TRAIL/PTX HSA-NP would have potential as a novel apoptosis-based anticancer agent. Copyright © 2015 Elsevier B.V. All rights reserved.

75 FR 26224 - Cheniere Creole Trail Pipeline, L.P.; Notice of Request Under Blanket Authorization

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... Creole Trail Pipeline, L.P.; Notice of Request Under Blanket Authorization May 4, 2010. Take notice that on April 29, 2010, Cheniere Creole Trail Pipeline, L.P. (Creole Trail), 700 Milam, Suite 800, Houston... 157.216(b) of the Commission's regulations under the Natural Gas Act (NGA). Creole Trail seeks...

75 FR 19646 - Cheniere Creole Trail Pipeline, L.P.; Notice of Request Under Blanket Authorization

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-15

... Creole Trail Pipeline, L.P.; Notice of Request Under Blanket Authorization April 7, 2010. Take notice that on April 2, 2010, Cheniere Creole Trail Pipeline, L.P. (Creole Trail), 700 Milam, Suite 800... Trail seeks authorization to construct and operate approximately 550 feet of 12-inch diameter pipe (no...

Compatibility of Ohio trail users

Treesearch

Roger E. McCay; George H. Moeller

1976-01-01

Compatibility indexes show how Ohio trail users feel about meeting each other on the trail. All four of the major types of trail users-hikers, horseback riders, bicycle riders, and motorcycle riders-enjoy meeting their own kind. But they also feel antagonism toward the faster, more mechanized trail users; e.g., everyone likes hikers, but few like motorcycle riders....

Walking through time: heritage resources within the Appalachian Trail corridor

Treesearch

David M. Lacy; Karl Roenke

1998-01-01

Parts of the Appalachian Trail (and nearly half of Vermont's Long Trail) are located on New England National Forests, and managed in partnership with the Appalachian Trail Conference, Green Mountain Club, and other volunteers. Since the Trail corridor is a linear, if serpentine, sample of northern Appalachian highland environments it's not surprising that it...

Behavioral evidence for multicomponent trail pheromone in the termite,Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae).

PubMed

Runcie, C D

1987-09-01

Evidence is presented for a multicomponent trail pheromone in the eastern subterranean termiteReticulitermes flavipes (Kollar). Choice tests were used to compare strength and persistency of trails made by termites in glass tubes. Tubes connected to termite nests for 24 hr were marked by termites with an extremely long-lasting chemical that persisted for at least one year, and a highly volatile substance that decayed in 15 min. Individual termites varied the trail they deposited under different circumstances. When removed from the nest and placed in a clean tube, they deposited a highly volatile substance. They left stronger and more persistent trails when exploring clean tubes attached to the nest. When they discovered a new food source, they left trails that were more attractive and far more persistent than trails made by exploring or displaced termites. A food trail made by 15 workers was still effective after 24 hr, whereas a trail made by 50 displaced workers, walking one after another through a tube, lasted only 5 min.

Assessing and Understanding Trail Degradation: Results from Big South Fork National River and Recreational Area

USGS Publications Warehouse

Marion, J.L.; Olive, N.

2006-01-01

This report describes results from a comprehensive assessment of resource conditions on a large (24%) sample of the trail system within Big South Fork National River and Recreational Area (BSF). Components include research to develop state-of-knowledge trail impact assessment and monitoring methods, application of survey methods to BSF trails, analysis and summary of results, and recommendations for trail management decision making and future monitoring. Findings reveal a trail system with some substantial degradation, particularly soil erosion, which additionally threatens water quality in areas adjacent to streams and rivers. Factors that contribute to or influence these problems are analyzed and described. Principal among these are trail design factors (trail topographic position, soil texture, grade and slope alignment angle), use-related factors (type and amount of use), and maintenance factors (water drainage). Recommendations are offered to assist managers in improving the sustainability of the trails system to accommodate visitation while enhancing natural resource protection.

The Cancer Moonshot Summit: Reaching New Heights

Cancer.gov

An NCI Cancer Currents blog from acting NCI Director Dr. Doug Lowy on the Cancer Moonshot national summit hosted by Vice President Joe Biden in Washington, D.C., including a summary of the NCI-related activities stimulated by the Cancer Moonshot.

75 FR 49550 - Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-13

.... FOR FURTHER INFORMATION CONTACT: Thomas Bolle, Office of Governmental, International and Public... this year's Summit will be handled separately by the National Organizations for Youth Safety. Thus, anyone who wishes to request exhibit space for the Summit should contact the National Organizations for...

The UAB University Transportation Center update : Vol. 4, No. 1.

DOT National Transportation Integrated Search

2010-01-01

Dr. Russ Fine, Dr. Despina Stavrinos and Ms. Crystal Franklin were invited by US DOT Secretary Ray LaHood to attend the 2010 Distracted Driving Summit held in Washington, DC in September. The Summit brought together leading transportation officials, ...

Spotlight on the Tribal Indoor Air Quality Summit Workgroup in Midwest Region 5

EPA Pesticide Factsheets

The Tribal IAQ Summit Workgroup uses a collaborative approach to increase the impact of tribes’ efforts to manage indoor air quality and improve community health for tribes in Illinois, Indiana, Michigan, Minnesota, Ohio and Wisconsin.

Episodic deflation-inflation events at Kīlauea Volcano and implications for the shallow magma system: Chapter 11

USGS Publications Warehouse

Anderson, Kyle R.; Poland, Michael; Johnson, Jessica H.; Miklius, Asta; Carey, Rebecca; Cayol, Valérie; Poland, Michael P.; Weis, Dominique

2015-01-01

Episodic variations in magma pressures and flow rates at Kīlauea Volcano, defined by a characteristic temporal evolution and termed deflation-inflation (DI) events, have been observed since at least the 1990s. DI events consist of transient, days-long deflations and subsequent reinflations of the summit region, accompanied since 2008 by fluctuations in the surface height of Kīlauea's summit lava lake. After a delay of minutes to hours, these events also often appear along the volcano's East Rift Zone in ground deformation data and as temporary reductions in eruption rate (sometimes followed by brief surges). Notable pauses in DI activity have preceded many eruptive events at Kīlauea. We analyzed more than 500 DI events recorded by borehole tiltmeters at the summit during 2000–2013. Inverse modeling suggests that DI-related ground deformation at the summit is generated by pressure transients in a shallow magma reservoir located beneath the east margin of Halema‘uma‘u Crater and that this reservoir has remained remarkably stable for more than a decade. Utilizing tilt data and variation in the level of the summit lava lake during a large DI event, we estimate a reservoir volume of approximately 1 km3 (0.2–5.5 km3 at 95% confidence).

A call to action: bold ideas from the Minnesota Women's Heart Summit.

PubMed

Ali, Nora; Lindquist, Ruth; Boucher, Jackie L; Witt, Dawn; Ambroz, Teresa; Konety, Suma H; Luepker, Russell; Windenburg, Denise; Hayes, Sharonne N

2012-05-01

Minnesota has the lowest overall coronary heart disease mortality rate in the United States. Yet disparities between men and women persist with regard to prevention, detection, and treatment. This has led to a gender gap not only in terms of care but also in survival rates. In an effort to better understand and close the gender gap, the Minneapolis Heart Institute, the Minneapolis Heart Institute Foundation, the University of Minnesota, and Mayo Clinic hosted a multidisciplinary Women's Heart Summit in April 2010. The goals of the summit were to stimulate dialogue and devise strategies to eliminate untimely deaths of women from heart disease. Summit participants were asked to contribute suggestions--called "Bold Ideas"--to address sex-based differences in the prevention, detection, and treatment of heart disease. Ideas were categorized according to three themes: educational programming, modifications to the health care system, and government involvement and funding. From these, several solutions emerged: 1) Involve obstetric/gynecologic physicians in providing heart-health education; 2) involve mid-level providers (midwives and other advanced practice women's health care providers) and other health professionals in women's heart health education, and 3) maximize the use of social media and online newsfeeds to raise awareness of heart disease in women. This article summarizes the discussion of the main ideas submitted by summit participants.

Efforts of a Kansas foundation to increase physical activity and improve health by funding community trails, 2012.

PubMed

Heinrich, Katie M; Lightner, Joseph; Oestman, Katherine B; Hughey, S Morgan; Kaczynski, Andrew T

2014-11-26

Trails are associated with increased physical activity; however, little is known about the process of building trails by various types of organizations. From 2005 through 2012 the Sunflower Foundation: Health Care for Kansans (Sunflower) funded multiple organizations to construct 70 trails of varying lengths and surfaces in municipalities, schools, and communities across Kansas. The purpose of this study was to assess the process of developing and implementing community trail projects across Kansas with funding from a public foundation. In 2012, we stratified funded organizations by type and conducted proportional random sampling to select 20 key informants from those organizations to participate in structured telephone interviews. Interviews were recorded and transcribed verbatim. Two researchers coded interview transcripts according to issues identified by participants. Issues associated with trail-building identified as important were collaboration among groups, unexpected construction costs, champions for the project, and level of difficulty of construction. Participants indicated that trails facilitated physical activity. Trails were integrated into communities through events such as walking events and other promotional efforts; these efforts were thought to increase trail use. The perceived outcomes of building the trails included providing the community with a physical activity resource, inspiring the community to start additional trail projects, and increasing the physical activity of local residents. Sunflower's funding was instrumental in developing trail projects to provide new physical activity resources across Kansas. Public health practitioners seeking to increase physical activity should seek funding from foundations that focus on health.

The dynamics of foraging trails in the tropical arboreal ant Cephalotes goniodontus.

PubMed

Gordon, Deborah M

2012-01-01

The foraging behavior of the arboreal turtle ant, Cephalotes goniodontus, was studied in the tropical dry forest of western Mexico. The ants collected mostly plant-derived food, including nectar and fluids collected from the edges of wounds on leaves, as well as caterpillar frass and lichen. Foraging trails are on small pieces of ephemeral vegetation, and persist in exactly the same place for 4-8 days, indicating that food sources may be used until they are depleted. The species is polydomous, occupying many nests which are abandoned cavities or ends of broken branches in dead wood. Foraging trails extend from trees with nests to trees with food sources. Observations of marked individuals show that each trail is travelled by a distinct group of foragers. This makes the entire foraging circuit more resilient if a path becomes impassable, since foraging in one trail can continue while a different group of ants forms a new trail. The colony's trails move around the forest from month to month; from one year to the next, only one colony out of five was found in the same location. There is continual searching in the vicinity of trails: ants recruited to bait within 3 bifurcations of a main foraging trail within 4 hours. When bait was offered on one trail, to which ants recruited, foraging activity increased on a different trail, with no bait, connected to the same nest. This suggests that the allocation of foragers to different trails is regulated by interactions at the nest.

Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy.

PubMed

Wang, Junjian; Wang, Haibin; Wang, Ling-Yu; Cai, Demin; Duan, Zhijian; Zhang, Yanhong; Chen, Peng; Zou, June X; Xu, Jianzhen; Chen, Xinbin; Kung, Hsing-Jien; Chen, Hong-Wu

2016-11-01

Recombinant TRAIL and agonistic antibodies to death receptors (DRs) have been in clinical trial but displayed limited anti-cancer efficacy. Lack of functional DR expression in tumors is a major limiting factor. We report here that chromatin regulator KDM4A/JMJD2A, not KDM4B, has a pivotal role in silencing tumor cell expression of both TRAIL and its receptor DR5. In TRAIL-sensitive and -resistant cancer cells of lung, breast and prostate, KDM4A small-molecule inhibitor compound-4 (C-4) or gene silencing strongly induces TRAIL and DR5 expression, and causes TRAIL-dependent apoptotic cell death. KDM4A inhibition also strongly sensitizes cells to TRAIL. C-4 alone potently inhibits tumor growth with marked induction of TRAIL and DR5 expression in the treated tumors and effectively sensitizes them to the newly developed TRAIL-inducer ONC201. Mechanistically, C-4 does not appear to act through the Akt-ERK-FOXO3a pathway. Instead, it switches histone modifying enzyme complexes at promoters of TRAIL and DR5 transcriptional activator CHOP gene by dissociating KDM4A and nuclear receptor corepressor (NCoR)-HDAC complex and inducing the recruitment of histone acetylase CBP. Thus, our results reveal KDM4A as a key epigenetic silencer of TRAIL and DR5 in tumors and establish inhibitors of KDM4A as a novel strategy for effectively sensitizing tumors to TRAIL pathway-based therapeutics.

Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy

PubMed Central

Wang, Junjian; Wang, Haibin; Wang, Ling-Yu; Cai, Demin; Duan, Zhijian; Zhang, Yanhong; Chen, Peng; Zou, June X; Xu, Jianzhen; Chen, Xinbin; Kung, Hsing-Jien; Chen, Hong-Wu

2016-01-01

Recombinant TRAIL and agonistic antibodies to death receptors (DRs) have been in clinical trial but displayed limited anti-cancer efficacy. Lack of functional DR expression in tumors is a major limiting factor. We report here that chromatin regulator KDM4A/JMJD2A, not KDM4B, has a pivotal role in silencing tumor cell expression of both TRAIL and its receptor DR5. In TRAIL-sensitive and -resistant cancer cells of lung, breast and prostate, KDM4A small-molecule inhibitor compound-4 (C-4) or gene silencing strongly induces TRAIL and DR5 expression, and causes TRAIL-dependent apoptotic cell death. KDM4A inhibition also strongly sensitizes cells to TRAIL. C-4 alone potently inhibits tumor growth with marked induction of TRAIL and DR5 expression in the treated tumors and effectively sensitizes them to the newly developed TRAIL-inducer ONC201. Mechanistically, C-4 does not appear to act through the Akt-ERK-FOXO3a pathway. Instead, it switches histone modifying enzyme complexes at promoters of TRAIL and DR5 transcriptional activator CHOP gene by dissociating KDM4A and nuclear receptor corepressor (NCoR)-HDAC complex and inducing the recruitment of histone acetylase CBP. Thus, our results reveal KDM4A as a key epigenetic silencer of TRAIL and DR5 in tumors and establish inhibitors of KDM4A as a novel strategy for effectively sensitizing tumors to TRAIL pathway-based therapeutics. PMID:27612013

Trail resource impacts and an examination of alternative assessment techniques

USGS Publications Warehouse

Marion, J.L.; Leung, Y.-F.

2001-01-01

Trails are a primary recreation resource facility on which recreation activities are performed. They provide safe access to non-roaded areas, support recreational opportunities such as hiking, biking, and wildlife observation, and protect natural resources by concentrating visitor traffic on resistant treads. However, increasing recreational use, coupled with poorly designed and/or maintained trails, has led to a variety of resource impacts. Trail managers require objective information on trails and their conditions to monitor trends, direct trail maintenance efforts, and evaluate the need for visitor management and resource protection actions. This paper reviews trail impacts and different types of trail assessments, including inventory, maintenance, and condition assessment approaches. Two assessment methods, point sampling and problem assessment, are compared empirically from separate assessments of a 15-mile segment of the Appalachian Trail in Great Smoky Mountains National Park. Results indicate that point sampling and problem assessment methods yield distinctly different types of quantitative information. The point sampling method provides more accurate and precise measures of trail characteristics that are continuous or frequent (e.g., tread width or exposed soil). The problem assessment method is a preferred approach for monitoring trail characteristics that can be easily predefined or are infrequent (e.g., excessive width or secondary treads), particularly when information on the location of specific trail impact problems is needed. The advantages and limitations of these two assessment methods are examined in relation to various management and research information needs. The choice and utility of these assessment methods are also discussed.

Recreation trails in Maine and New Hampshire: A comparison of notorized, non-motorized, and non-mechanized trails

Treesearch

Ethel Wilkerson; Andrew. Whitman

2010-01-01

We sampled 112 trail segments in Maine and New Hampshire to assess the impact of motorized and non-motorized recreation on trail conditions and stream sedimentation. On each segment, we assessed physical trail conditions (width, cross-sectional area, occurrence of excessively muddy and rutted/eroded sections), presence of trash, and sedimentation at stream crossings....

77 FR 56117 - Special Regulations, Areas of the National Park System; Mammoth Cave National Park, Bicycle Routes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-12

...; the Mammoth Cave Railroad Bike & Hike Trail; and the White Oak Trail. DATES: The rule is effective... rivers. In 2007, the Mammoth Cave Railroad Bike & Hike Trail was completed, connecting the heart of the... hiking, approximately 55 miles of trail are open to horses, approximately 17 miles of trail are open to...

76 FR 28388 - Special Regulations, Areas of the National Park System, Mammoth Cave National Park

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-17

...; the nine-mile Mammoth Cave Railroad Bike & Hike Trail; and the White Oak Trail. DATES: Comments must... services on the Green and Nolin rivers. In 2005, the Mammoth Cave Railroad Bike & Hike Trail was completed.... While all trails are open to hiking, approximately 44.5 miles of trail are open to horses, approximately...

TRAIL-CM4 fusion protein shows in vitro antibacterial activity and a stronger antitumor activity than solo TRAIL protein.

PubMed

Sang, Ming; Zhang, Jiaxin; Li, Bin; Chen, Yuqing

2016-06-01

A TRAIL-CM4 fusion protein in soluble form with tumor selective apoptosis and antibacterial functions was expressed in the Escherichia coli expression system and isolated through dialysis refolding and histidine-tag Nickel-affinity purification. Fresh Jurkat cells were treated with the TRAIL-CM4 fusion protein. Trypan blue staining and MTT analyses showed that, similar to a TRAIL positive control, Jurkat cell proliferation was significantly inhibited. Flow cytometry analyses using Annexin V-fluorescein revealed that Jurkat cells treated with the TRAIL-CM4 fusion protein exhibited increased apoptosis. Laser confocal microscopy showed that APB-CM4 and the fusion protein TRAIL-CM4 can bind to Jurkat cell membranes and initiate their destruction. ABP-CM4 enhances the antitumor activity of TRAIL by targeting and damaging the tumor cell membrane. In antibacterial experiments, agar well diffusion and bacterial growth inhibition curve assays revealed concentration-dependent TRAIL-CM4 antibacterial activity against Escherichia coli K12D31. The expressed TRAIL-CM4 fusion protein exhibited enhanced antitumor and antibacterial activities. Fusion protein expression allowed the two different proteins to function in combination. Copyright © 2016 Elsevier Inc. All rights reserved.

Effects of the Built Environment on Childhood Obesity: the Case of Urban Recreational Trails and Crime

PubMed Central

Sandy, Robert; Tchernis, Rusty; Wilson, Jeff; Liu, Gilbert; Zhou, Xilin

2012-01-01

We study the effects of urban environment on childhood obesity by concentrating on the effects of walking trails and crime close to children’s homes on their BMI and obesity status. We use a unique dataset, which combines information on recreational trails in Indianapolis with data on violent crimes and anthropomorphic and diagnostic data from children’s clinic visits between 1996 and 2005. We find that having a trail near a home reduces children’s weight. However, the effect depends on the amount of nearby violent crimes. Significant reductions occur only in low crime areas and trails could have opposite effects on weight in high crime areas. These effects are primarily among boys, older children, and children who live in higher income neighborhoods. Evaluated at the mean length of trails this effect for older children in no crime areas would be a reduction of two pounds of the body weight. Falsification tests using planned trails instead of existing trails, show that trails are more likely to be located in areas with heavier children, suggesting that our results on effects of trails represent a lower bound. PMID:22459489

Effects of the built environment on childhood obesity: the case of urban recreational trails and crime.

PubMed

Sandy, Robert; Tchernis, Rusty; Wilson, Jeffrey; Liu, Gilbert; Zhou, Xilin

2013-01-01

We study the effects of urban environment on childhood obesity by concentrating on the effects of walking trails and crime close to children's homes on their BMI and obesity status. We use a unique dataset, which combines information on recreational trails in Indianapolis with data on violent crimes and anthropomorphic and diagnostic data from children's clinic visits between 1996 and 2005. We find that having a trail near a home reduces children's weight. However, the effect depends on the amount of nearby violent crimes. Significant reductions occur only in low crime areas and trails could have opposite effects on weight in high crime areas. These effects are primarily among boys, older children, and children who live in higher income neighborhoods. Evaluated at the mean length of trails this effect for older children in no crime areas would be a reduction of 2 lb of the body weight. Falsification tests using planned trails instead of existing trails, show that trails are more likely to be located in areas with heavier children, suggesting that our results on effects of trails represent a lower bound. Published by Elsevier B.V.

A Tale of Two Trails: Exploring Different Paths to Success

PubMed Central

Walker, Jennifer G.; Evenson, Kelly R.; Davis, William J.; Bors, Philip; Rodríguez, Daniel A.

2016-01-01

Background This comparative case study investigates 2 successful community trail initiatives, using the Active Living By Design (ALBD) Community Action Model as an analytical framework. The model includes 5 strategies: preparation, promotion, programs, policy, and physical projects. Methods Key stakeholders at 2 sites participated in in-depth interviews (N = 14). Data were analyzed for content using Atlas Ti and grouped according to the 5 strategies. Results Preparation Securing trail resources was challenging, but shared responsibilities facilitated trail development. Promotions The initiatives demonstrated minimal physical activity encouragement strategies. Programs Community stakeholders did not coordinate programmatic opportunities for routine physical activity. Policy Trails’ inclusion in regional greenway master plans contributed to trail funding and development. Policies that were formally institutionalized and enforced led to more consistent trail construction and safer conditions for users. Physical Projects Consistent standards for way finding signage and design safety features enhanced trail usability and safety. Conclusions Communities with different levels of government support contributed unique lessons to inform best practices of trail initiatives. This study revealed a disparity between trail development and use-encouragement strategies, which may limit trails’ impact on physical activity. The ALBD Community Action Model provided a viable framework to structure cross-disciplinary community trail initiatives. PMID:21597125

Population dynamics of American dog ticks (Acari: Ixodidae) along park trails

USGS Publications Warehouse

Carroll, J.F.; Russek-Cohen, E.; Nichols, J.D.; Hines, J.E.

1991-01-01

We conclude a mark-recapture study in which drag-collected ticks were removed from some park trails weekly from April to July. Weekly survival rates (probability of surviving and remaining on the trails) were significantly lower on trials used heavily by hikers, horses, and pets than on trails used less frequently. Although usage was the only obvious difference among these trails, differences in weekly survival rate estimates may be attributable to differential success in acquiring hosts. The estimated probability of capturing a host-seeking tick located along a trail on a single drag was 0.20 on the drag alone, and 0.25 including the person dragging. When routes parallel to the trails and of equal lengths were dragged immediately after sampling the trails, only .apprxeq. 5% as many ticks (including ticks on the person dragging) were found off the trails as on them. We found no evidence of reduced tick numbers on removal trails, but this result should be considered inconclusive because the power of the discerning test was low. However, the data reported here provide insights into turnover rates of the adult Dermacentor variabilis population and effectiveness of the drag as a sampling device.

Impacts of Different Hiking-trail Use Frequency on Soil Erosion: a Case of Mt. Mudeng National Park, Korea

NASA Astrophysics Data System (ADS)

Kim, J.; Kim, J. K.

2017-12-01

Mountain National Parks have been suffered serious soil erosion by hiking in Korea. To identify the impacts of different human's trampling intensities, a comparative study was conducted in Mt. Mudeungsan National Park where has been very intensive recreational activities. For this study, trail-conditions and soil properties were discovered on the 1.9km trail of high traffic (A) and 3.8km trail of low traffic (B) in the study area. Width was significantly wider on the A than B, but there was no significant difference in the values of other factors. With compaction and erosion of topsoil on the trail, penetration resistance and bulk density were significantly higher, but water content and the ratio of silt and clay were significantly lower than those of undisturbed areas around the trails. These were not statistically significant spatial difference from the use frequency of the trails. This result implies that the characteristics of surface soil on trails were not largely affected by use frequency, and the evolution of cross-section form of trails would be dominated by widening. This study will help in managing trail system and establishing conservation policy sustainably.

Validation of Walking Trails for the Urban TrainingTM of Chronic Obstructive Pulmonary Disease Patients

PubMed Central

Arbillaga-Etxarri, Ane; Torrent-Pallicer, Jaume; Gimeno-Santos, Elena; Barberan-Garcia, Anael; Delgado, Anna; Balcells, Eva; Rodríguez, Diego A.; Vilaró, Jordi; Vall-Casas, Pere; Irurtia, Alfredo; Rodriguez-Roisin, Robert; Garcia-Aymerich, Judith

2016-01-01

Purpose Accessible interventions to train patients with chronic obstructive pulmonary disease (COPD) are needed. We designed urban trails of different intensities (low, moderate and high) in different types of public spaces (boulevard, beach and park). We aimed to validate the trails’ design by assessing the physiological response to unsupervised walking trails of: (1) different intensities in COPD patients, and (2) same intensity from different public spaces in healthy adults. Methods On different days and under standardized conditions, 10 COPD patients walked the three intensity trails designed in a boulevard space, and 10 healthy subjects walked the three intensity trails in three different spaces. We measured physiological response and energy expenditure using a gas analyzer. We compared outcomes across trails intensity and/or spaces using mixed-effects linear regression. Results In COPD patients, physiological response and energy expenditure increased significantly according to the trails intensity: mean (SD) peak V˙O2 15.9 (3.5), 17.4 (4.7), and 17.7 (4.4) mL/min/kg (p-trend = 0.02), and MET-min 60 (23), 64 (26), 72 (31) (p-trend<0.01) in low, moderate and high intensity trails, respectively. In healthy subjects there were no differences in physiological response to walking trails of the same intensity across different spaces. Conclusions We validated the trails design for the training of COPD patients by showing that the physiological response to and energy expenditure on unsupervised walking these trails increased according to the predefined trails’ intensity and did not change across trails of the same intensity in different public space. Walkable public spaces allow the design of trails that could be used for the training of COPD patients in the community. PMID:26766184

Volcano Observations Using an Unmanned Autonomous Helicopter : seismic and GPS observations near the active summit area of Sakurajima and Kirishima volcano, Japan

NASA Astrophysics Data System (ADS)

Ohminato, T.; Kaneko, T.; Koyama, T.; Watanabe, A.; Takeo, M.; Iguchi, M.; Honda, Y.

2012-04-01

Observations in the vicinity of summit area of active volcanoes are very important from various viewpoints such as understanding physical processes in the volcanic conduit. It is, however, highly difficult to install observation sensors near active vents because of the risk of sudden eruptions. We have been developing a safe volcano observation system based on an unmanned aerial vehicle (UAV). As an UAV, we adopted an unmanned autonomous helicopter manufactured by Yamaha-Motor Co., Ltd. We have also developed earthquake observation modules and GPS receiver modules that are exclusively designed for UAV installation at summit areas of active volcanoes. These modules are light weight, compact size, and solar powered. For data transmission, a commercial cellular-phone network is used. Our first application of the sensor installation by the UAV is Sakurajima, one of the most active volcanos in Japan. In November 2009, 2010, and 2011, we installed up to four seismic sensors within 2km from the active summit crater. In the 2010 and 2011 operations, we succeeded in pulling up and collecting the sensor modules by using the UAV. In the 2011 experiment, we installed two GPS receivers near the summit area of Sakurajima volcano. We also applied the UAV installation to another active volcano, Shinmoedake in Kirishima volcano group. Since the sub-plinian eruption in February 2011, entering the area 3km from the summit of Shinmoe-dake has been prohibited. In May and November 2011, we installed seismic sensors and GPS receivers in the off-limit zone. Although the ground coupling of the seismic modules is not perfect due to the way they are installed, the signal-to-noise ratio of the seismic signals recorded by these modules is fairly good. Despite the low antenna height of 50 cm from the ground surface, the location errors in horizontal and vertical GPS components are 1cm and 3cm, respectively. For seismic signals associated with eruptions at Sakurajima from November 2010 to November 2011, we measure temporal variation of the amplitude ratio among the summit stations. In order to correct the amplitude variation due to the source amplitude variation, the amplitude of the recorded signals are normalized by using the amplitude of a permanent station, located on the western flank of Sakurajima 5km from the summit. The daily average of the normalized amplitude ratios among the summit stations shows clear temporal variation. The amplitude ratio variation can be classified to three stages. In the first stage, the amplitude ratios among the summit stations are nearly constant. The 2nd stage is characterized by a gradual increase in the amplitude ratio. The third stage is slightly difficult to define but we can say that the amplitude ratios are almost constant with fluctuations larger than that in the first stage. These changes strongly suggest a change in the source depth, probably migration of the source to the shallower portion in the volcanic conduit. Small change in the source position would have been observed as a big change in the observed amplitude ratio due to the closeness of the sensors to the source.

Proceedings of the Great Lakes silviculture summit

Treesearch

Brian Palik; Louise (ed.) Levy

2004-01-01

The goal of the Great Lakes Silviculture Summit was to identify a research agenda that captures the priority information needs of diverse organizations in the region. These needs and the resultant research agenda are presented in the series of papers in these proceedings.

Humans to Mars Summit 2014

NASA Image and Video Library

2014-04-22

NASA Administrator Charles Bolden delivers the opening keynote address at the Humans to Mars Summit on April 22, 2014 at George Washington University in Washington, DC. Administrator Bolden spoke of NASA's path to the human exploration of Mars during his remarks. Photo Credit: (NASA/Joel Kowsky)

8. Historic American Buildings Survey Photocopy of an old view, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey Photocopy of an old view, ca. 1920 From collection of Anna B. Scherer, Lees Summit, Mo. SOUTHEAST AND NORTHEAST FACADES WITH GARAGE/POWERHOUSE PRIOR TO GREENHOUSE MANGER'S HOUSE - Longview Farm, Greenhouses, Lees Summit, Jackson County, MO

Patients with Ankylosing Spondylitis and Low Disease Activity because of Anti-TNF-Alpha Therapy Have Higher TRAIL Levels Than Controls: A Potential Compensatory Effect

PubMed Central

López-Mejías, Raquel; Rueda-Gotor, Javier; Miranda-Filloy, José A.; Ubilla, Begoña; Carnero-López, Beatriz; Palmou-Fontana, Natalia; Gómez-Acebo, Inés; Blanco, Ricardo; Pina, Trinitario; Ochoa, Rodrigo; González-Juanatey, Carlos; González-Gay, Miguel A.

2014-01-01

Objective. TRAIL is a potential biomarker of cardiovascular (CV) disease. Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with metabolic syndrome (MeS) and accelerated atherosclerosis. We assessed whether disease activity, systemic inflammation, and MeS features were associated with circulating TRAIL levels in AS patients undergoing TNF-α antagonist infliximab therapy and if infliximab infusion modified TRAIL levels. Methods. We measured TRAIL serum levels in 30 nondiabetic AS patients without CV disease undergoing anti-TNF-α therapy, immediately before and after an infliximab infusion, and in 48 matched controls. Correlations of TRAIL levels with disease activity, systemic inflammation and MeS features, adipokines, and biomarkers of endothelial activation were evaluated. Changes in TRAIL levels following anti-TNF-α infusion were analyzed. Results. TRAIL levels were higher in AS patients than controls. TRAIL levels displayed an inverse correlation with total and LDL cholesterol. We observed an inverse correlation with QUICKI and a marginal association with HOMA-IR. We also found an inverse correlation with resistin and a marginal association with apelin and OPN. Anti-TNF-α infusion did not change TRAIL levels after 120′. Conclusion. Elevated TRAIL levels in AS patients may be the result of a compensatory mechanism to reduce CV risk in these patients. PMID:24976690

Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation.

PubMed

Luan, Zhou; He, Ying; He, Fan; Chen, Zhishui

2015-01-01

The enhancement of apoptosis is a therapeutic strategy used in the treatment of cancer. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising antitumor agent. However, hepatocellular carcinoma (HCC) cells exhibit marked resistance to the induction of cell death by TRAIL. The present study investigated whether rocaglamide, a naturally occurring product isolated from the genus Aglaia, is able to sensitize resistant HCC cells to TRAIL-mediated apoptosis. Two HCC cell lines, HepG2 and Huh-7, were treated with rocaglamide and/or TRAIL and the induction of apoptosis and effects on the TRAIL signaling pathway were investigated. The in vivo efficacy of rocaglamide was determined in TRAIL-resistant Huh-7-derived tumor xenografts. Rocaglamide significantly sensitized the TRAIL-resistant HCC cells to apoptosis by TRAIL, which resulted from the rocaglamide-mediated downregulation of cellular FLICE-like inhibitory protein and subsequent caspase-8 activation. Furthermore, rocaglamide markedly inhibited tumor growth from Huh-7 cells propagated in severe combined immunodeficient mice, suggesting that chemosentization also occurred in vivo. These data suggest that rocaglamide acted synergistically with TRAIL against the TRAIL-resistant HCC cells. Thus, it is concluded that rocaglamide as an adjuvant to TRAIL-based therapy may present a promising therapeutic approach for the treatment of HCC.

Spectra of Full 3-D PIC Simulations of Finite Meteor Trails

NASA Astrophysics Data System (ADS)

Tarnecki, L. K.; Oppenheim, M. M.

2016-12-01

Radars detect plasma trails created by the billions of small meteors that impact the Earth's atmosphere daily, returning data used to infer characteristics of the meteoroid population and upper atmosphere. Researchers use models to investigate the dynamic evolution of the trails. Previously, all models assumed a trail of infinite length, due to the constraints of simulation techniques. We present the first simulations of 3D meteor trails of finite length. This change more accurately captures the physics of the trails. We characterize the turbulence that develops as the trail evolves and study the effects of varying the external electric field, altitude, and initial density. The simulations show that turbulence develops in all cases, and that trails travel with the neutral wind rather than electric field. Our results will allow us to draw more detailed and accurate information from non-specular radar observations of meteors.

Aggregation-fragmentation-diffusion model for trail dynamics

DOE PAGES

Kawagoe, Kyle; Huber, Greg; Pradas, Marc; ...

2017-07-21

We investigate statistical properties of trails formed by a random process incorporating aggregation, fragmentation, and diffusion. In this stochastic process, which takes place in one spatial dimension, two neighboring trails may combine to form a larger one, and also one trail may split into two. In addition, trails move diffusively. The model is defined by two parameters which quantify the fragmentation rate and the fragment size. In the long-time limit, the system reaches a steady state, and our focus is the limiting distribution of trail weights. We find that the density of trail weight has power-law tail P(w)~w –γ formore » small weight w. We obtain the exponent γ analytically and find that it varies continuously with the two model parameters. In conclusion, the exponent γ can be positive or negative, so that in one range of parameters small-weight trails are abundant and in the complementary range they are rare.« less

Fiscal Year 2013 Trails Management Program Mitigation Action Plan Annual Report, October 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pava, Daniel S.

This Trails Management Program Mitigation Action Plan Annual Report (Trails MAPAR) has been prepared for the Department of Energy (DOE)/National Nuclear Security Administration (NNSA) as part of implementing the 2003 Final Environmental Assessment for the Proposed Los Alamos National Laboratory Trails Management Program (DOE 2003). The Trails Mitigation Action Plan (MAP) is now a part of the Site-Wide Environmental Impact Statement for the Continued Operation of Los Alamos National Laboratory (DOE/EIS 0380) Mitigation Action Plan (2008 SWEIS MAP) (DOE 2008). The MAP provides guidance for the continued implementation of the Trails Management Program at Los Alamos National Laboratory (LANL) andmore » integration of future mitigation actions into the 2008 SWEIS MAP to decrease impacts associated with recreational trails use at LANL. This eighth MAPAR includes a summary of Trails Management Program activities and actions during Fiscal Year (FY) 2013, from October 2012 through September 2013.« less

Volcanic gas emissions and their impact on ambient air character at Kilauea Volcano, Hawaii

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutton, A.J.; Elias, T.; Navarrete, R.

1994-12-31

Gas emissions from Kilauea occur from the summit caldera, along the middle East Rift Zone (ERZ), and where lava enters the ocean. We estimate that the current ERZ eruption of Kilauea releases between 400 metric tonnes of SO{sub 2} per day, during eruptive pauses, to as much as 1850 metric tonnes per day during actively erupting periods, along with lesser amounts of other chemically and radiatively active species including H{sub 2}S, HCl and HF. In order to characterize gas emissions from Kilauea in a meaningful way for assessing environmental impact, we made a series of replicate grab-sample measurements of ambientmore » air and precipitation at the summit of Kilauea, along its ERZ, and at coastal sites where lava enters the ocean. The grab-sampling data combined with SO{sub 2} emission rates, and continuous air quality and meteorological monitoring at the summit of Kilauea show that the effects of these emissions on ambient air character are a complex function of chemical reactivity, source geometry and effusivity, and local meteorology. Prevailing tradewinds typically carry the gases and aerosols released to the southwest, where they are further distributed by the regional wind regime. Episodes of kona, or low speed variable winds sometimes disrupt this pattern, however, and allow the gases and their oxidation products to collect at the summit and eastern side of the island. Summit solfatara areas of Kilauea are distinguished by moderate to high ambient SO{sub 2}, high H{sub 2}S at one location, and low H{sub 2}S at all others, and negligible HCl concentrations, as measured 1 m from degassing point-sources. Summit solfatara rain water has high sulfate and low chloride ion concentrations, and low pH.« less

Women's human rights at the World Summit for Social Development.

PubMed

Fried, S

1995-01-01

The Copenhagen Hearing on Economic Justice and Women's Human Rights was held on March 7, 1995 in conjunction with the NGO (nongovernmental organization) Forum during the UN World Summit on Social Development (the Social Summit). During the Copenhagen Hearing, 10 women from around the world testified on a wide range of topics connected with the issue of providing tangible meaning to the indivisibility of women's human rights. Also emphasized was the complexity of the US government in perpetrating abuses against women's human rights, either directly or indirectly. The NGO Forum resulted in several hundred NGOs signing The Quality Benchmark for the Social Summit and The Copenhagen Alternative Declaration, which pointed out the need to critique conventional economic and social policies. While many of the concerns raised at the NGO Forum were not reflected in the Summit's Programme of Action, one of the Programme's 10 commitments called for the promotion of gender equality and improvement in the status of women. The Programme also recognized the burden placed on women by poverty and social disintegration; accepted a broad definition of "family"; called for a quantitative consideration of the value of unremunerated work; and advanced the rights of workers in general, migrant workers, and indigenous people. The capacity of NGOs and other grassroots groups to demand implementation of international agreements and adherence to international human rights standards was also strengthened. Specifically, such groups may urge governments to 1) meet with women's NGOs to discuss implementation of the Social Summit Declaration and Programme of Action; 2) make a national commitment to implement the Platform of Action of the Fourth World Conference on Women; and 3) commit to the Pledge to Gender Justice, particularly to the implementation of international agreements in local and national laws and policies.

Mortality on Mount Everest, 1921-2006: descriptive study

PubMed Central

Zheng, Hui; Windsor, Jeremy S; Sutherland, Andrew I; Imray, Christopher H; Moore, G W K; Semple, John L; Roach, Robert C; Salisbury, Richard A

2008-01-01

Objective To examine patterns of mortality among climbers on Mount Everest over an 86 year period. Design Descriptive study. Setting Climbing expeditions to Mount Everest, 1921-2006. Participants 14 138 mountaineers; 8030 climbers and 6108 sherpas. Main outcome measure Circumstances of deaths. Results The mortality rate among mountaineers above base camp was 1.3%. Deaths could be classified as involving trauma (objective hazards or falls, n=113), as non-traumatic (high altitude illness, hypothermia, or sudden death, n=52), or as a disappearance (body never found, n=27). During the spring climbing seasons from 1982 to 2006, 82.3% of deaths of climbers occurred during an attempt at reaching the summit. The death rate during all descents via standard routes was higher for climbers than for sherpas (2.7% (43/1585) v 0.4% (5/1231), P<0.001; all mountaineers 1.9%). Of 94 mountaineers who died after climbing above 8000 m, 53 (56%) died during descent from the summit, 16 (17%) after turning back, 9 (10%) during the ascent, 4 (5%) before leaving the final camp, and for 12 (13%) the stage of the summit bid was unknown. The median time to reach the summit via standard routes was earlier for survivors than for non-survivors (0900-0959 v 1300-1359, P<0.001). Profound fatigue (n=34), cognitive changes (n=21), and ataxia (n=12) were the commonest symptoms reported in non-survivors, whereas respiratory distress (n=5), headache (n=0), and nausea or vomiting (n=3) were rarely described. Conclusions Debilitating symptoms consistent with high altitude cerebral oedema commonly present during descent from the summit of Mount Everest. Profound fatigue and late times in reaching the summit are early features associated with subsequent death. PMID:19074222

MEETING REPORT: UNESCO-MERCK AFRICA RESEARCH SUMMIT 2015- ACCELERATING ACCESS AND SUSTAINING INNOVATION ‘FROM AFRICA FOR AFRICA’

PubMed Central

Omange, R.W.; Ocholla, A.O.; Kwallah., A.O; Kageha, S. N.; Mwangi, J.; Cherutich, R. K; T.A., Odeny.; Nzomo, T.; Angwenyi, S.; Yonga., P; Kariuki, F.; Kyalo, M.; Mutai, P.C.; Nindo, F.; Songok, E.M

2017-01-01

Background: The Ebola virus disease outbreak of 2014 was the largest, longest and most devastating in the history of the disease. It demonstrated the social and economic impact an emerging infectious disease can have in a globalized world. Health systems in affected countries were stretched to the point of near collapse, while social relations and traditional practices were negatively impacted. Heads of African research institutions, African government representatives, leaders of global pharmaceutical companies, global infectious disease experts and close to 100 young African researchers from 25 countries; Assembled in Geneva on 19 and 20th October 2015, for the inaugural UNESCO-Merck Africa Summit sponsored by the United Nations Educational, Science and Culture Organization and Merck KGA Goal of Summit: The primary goal of the summit was to develop strategies to increase health research capacity in Africa, with special focus on Ebola and enhancing pandemic preparation for emerging infectious diseases. The summit was also provide a forum to showcase the research taking place in Africa, and provided platform for African researchers to network. Some of the key issues discussed included; strategies for enhancing policy frameworks to promote knowledge translation, strengthening of health systems, enhancing knowledge and data sharing, and increasing innovation in Africa. Conclusions: Summit attendees recognized that Africa still bore the heaviest burden of infectious disease, and increased commitment by African governments to fund health research, offered the best hope for developing health solutions and interventions to improve the health of Africans. Improved health in turn would enhance the productivity of Africans, further supporting the socio-economic transformation currently taking place on the continent. PMID:28337491

Elevation, Substrate, & Climate effects on Alpine & Sub-Alpine Plant Distribution in California & Nevada's High Mountains: Preliminary Data from the California and Nevada GLORIA Project

NASA Astrophysics Data System (ADS)

Barber, A.; Millar, C.

2014-12-01

Documenting plant response to global climate change in sensitive zones, such as the alpine, is a major goal for global change biology. Basic information on alpine plant distribution by elevation and substrate provides a basis for anticipating which species may decline in a warming climate. The Global Observation Research Initiative in Alpine Environments (GLORIA) is a worldwide effort to document vegetation changes over time in alpine settings using permanent multi-summit plots. The California/Nevada group currently monitors seven permanent GLORIA target regions, composed of 29 summits in alpine and subalpine zones. Summits range in elevations from 2918m to 4325m on substrates including dolomite, granite, quartzite, and volcanics. High-resolution plant occurrence and cover data from the upper 10 meters of each summit are presented. Plants from our target regions can be divided into three groups: summit specialists found only on the highest peaks, alpine species found predominantly within the alpine zone, and broadly distributed species found in the alpine zone and below. Rock substrate and microsite soil development have a strong influence on plant communities and species richness. We present the first set of five-year resurvey and temperature data from 18 summits. We have documented some annual variation in species presence/absence at almost all sites, but no dramatic changes in total diversity. Consistent with the expectation of rising global temperatures, our soil temperature loggers have documented temperature increases at most of our sites. These data are a baseline for assessing bioclimatic shifts and future plant composition in California and Nevada's alpine zone.

Hiking shared-use single-track trails: a look at hikers and hunters along the Falls Lake Trail

Treesearch

Christopher M. Snow; Roger L. Moore

2007-01-01

The Falls Lake Trail, a 26.8-mile, single-track pedestrian trail located near the Research Triangle Region of North Carolina, traverses lands managed by the United States Army Corps of Engineers; North Carolina Division of Parks and Recreation; North Carolina Division of Wildlife Resources; and Wake County Parks, Recreation and Open Space. The non-profit trail advocacy...

Trail deterioration as an indicator of trail use in an urban forest recreation area

Treesearch

Thomas A. More

1980-01-01

The average width of a trail was used to predict trail use in an urban forest recreation area. Results show that width indicates use only very generally at best. Consequently, simply inspecting the physical condition of a trail may lead to erroneous conclusions about its use. Managers requiring more than a simple light use/heavy use classification should adopt more...

Sediment pathways in a tropical forest: effects of logging roads and skid trails

NASA Astrophysics Data System (ADS)

Sidle, Roy C.; Sasaki, Shozo; Otsuki, Mieko; Noguchi, Shoji; Rahim Nik, Abdul

2004-03-01

Significant erosion occurred from recently constructed forest logging roads and skid trails in a small headwater catchment in Peninsular Malaysia. Soil loss was estimated by measuring dimensions of all significant rills and gullies along the road, as well as by measuring height of preserved soil pedestals in sidecast and fill material and on skid trails. Estimates of surface erosion from logging roads and skid trails were 272 +/- 20 t ha-1 year-1 and 275 +/- 20 t ha-1 year-1 respectively. However, owing to lack of connectivity of skid trails to the stream, much of the sediment mobilized on skid trails was stored either on adjacent hillslopes or the trails themselves, rather than being transported to the stream system, as was the case for the road. Steeper skid trails (>20% gradient) had slightly higher erosion rates (320 +/- 24 t ha-1 year-1) than trails with gentler gradients (245-264 t ha-1 year-1). Some 60% of the soil loss on logging roads comes from erosion of the running surface. Disturbed cut and fill material along the road supplied the remaining 40% of the soil loss from roads. Roads and skid trails had no designed drainage systems; runoff discharged onto the hillslope at 25 major discharge nodes from the logging road (690 m total length) and at 34 nodes from skid trails (2300 m). Sediment pathways were either fully or moderately connected to headwater channels at 64% of the logging road nodes, but at only 26% of the nodes emanating from skid trails. A detailed sediment budget revealed that 78% of the soil loss from the road system (including log landings) was delivered to the stream in the first 16 months after logging began. Most (90%) of the deposition from skid trails occurred below just three discharge nodes. Runoff from and onto skid trails often exacerbated the sediment connectivity to channels. Clearly, sediment discharge from logging roads was more highly connected to the stream than discharge from skid trails. Once in the channel, much of this sediment was temporarily stored in the floodplain and behind woody debris.

Human CD34+ cells engineered to express membrane-bound tumor necrosis factor-related apoptosis-inducing ligand target both tumor cells and tumor vasculature.

PubMed

Lavazza, Cristiana; Carlo-Stella, Carmelo; Giacomini, Arianna; Cleris, Loredana; Righi, Marco; Sia, Daniela; Di Nicola, Massimo; Magni, Michele; Longoni, Paolo; Milanesi, Marco; Francolini, Maura; Gloghini, Annunziata; Carbone, Antonino; Formelli, Franca; Gianni, Alessandro M

2010-03-18

Adenovirus-transduced CD34+ cells expressing membrane-bound tumor necrosis factor-related apoptosis-inducing ligand (CD34-TRAIL+ cells) exert potent antitumor activity. To further investigate the mechanism(s) of action of CD34-TRAIL+ cells, we analyzed their homing properties as well as antitumor and antivascular effects using a subcutaneous myeloma model in immunodeficient mice. After intravenous injection, transduced cells homed in the tumor peaking at 48 hours when 188 plus or minus 25 CD45+ cells per 10(5) tumor cells were detected. Inhibition experiments showed that tumor homing of CD34-TRAIL+ cells was largely mediated by vascular cell adhesion molecule-1 and stromal cell-derived factor-1. Both CD34-TRAIL+ cells and soluble (s)TRAIL significantly reduced tumor volume by 40% and 29%, respectively. Computer-aided analysis of TdT-mediated dUTP nick end-labeling-stained tumor sections demonstrated significantly greater effectiveness for CD34-TRAIL+ cells in increasing tumor cell apoptosis and necrosis over sTRAIL. Proteome array analysis indicated that CD34-TRAIL+ cells and sTRAIL activate similar apoptotic machinery. In vivo staining of tumor vasculature with sulfosuccinimidyl-6-(biotinamido) hexanoate-biotin revealed that CD34-TRAIL+ cells but not sTRAIL significantly damaged tumor vasculature, as shown by TdT-mediated dUTP nick end-labeling+ endothelial cells, appearance of hemorrhagic areas, and marked reduction of endothelial area. These results demonstrate that tumor homing of CD34-TRAIL+ cells induces early vascular disruption, resulting in hemorrhagic necrosis and tumor destruction.

Efforts of a Kansas Foundation to Increase Physical Activity and Improve Health by Funding Community Trails, 2012

PubMed Central

Heinrich, Katie M.; Lightner, Joseph; Oestman, Katherine B.; Kaczynski, Andrew T.

2014-01-01

Introduction Trails are associated with increased physical activity; however, little is known about the process of building trails by various types of organizations. From 2005 through 2012 the Sunflower Foundation: Health Care for Kansans (Sunflower) funded multiple organizations to construct 70 trails of varying lengths and surfaces in municipalities, schools, and communities across Kansas. The purpose of this study was to assess the process of developing and implementing community trail projects across Kansas with funding from a public foundation. Methods In 2012, we stratified funded organizations by type and conducted proportional random sampling to select 20 key informants from those organizations to participate in structured telephone interviews. Interviews were recorded and transcribed verbatim. Two researchers coded interview transcripts according to issues identified by participants. Results Issues associated with trail-building identified as important were collaboration among groups, unexpected construction costs, champions for the project, and level of difficulty of construction. Participants indicated that trails facilitated physical activity. Trails were integrated into communities through events such as walking events and other promotional efforts; these efforts were thought to increase trail use. The perceived outcomes of building the trails included providing the community with a physical activity resource, inspiring the community to start additional trail projects, and increasing the physical activity of local residents. Conclusion Sunflower’s funding was instrumental in developing trail projects to provide new physical activity resources across Kansas. Public health practitioners seeking to increase physical activity should seek funding from foundations that focus on health. PMID:25427316

How Networks of Informal Trails Cause Landscape Level Damage to Vegetation.

PubMed

Barros, Agustina; Marina Pickering, Catherine

2017-07-01

When visitors are not constrained to remain on formal trails, informal trail networks can develop and damage plant communities in protected areas. These networks can form in areas with low growing vegetation, where formal trails are limited, where there is limited regulation and where vegetation is slow to recover once disturbed. To demonstrate the extent of impacts from unregulated recreational use, we assessed damage to alpine vegetation by hikers and pack animals in the highest protected area in the southern Hemisphere: Aconcagua Park, in the Andes. Within the 237 ha area surveyed in the Horcones Valley, over 19 km of trails were found, nearly all of which (94%) were informal. This network of trails resulted in the direct loss of 11.5 ha of vegetation and extensive fragmentation of alpine meadows (21 fragments) and steppe vegetation (68 fragments). When levels of disturbance off these trails were quantified using rapid visual assessments, 81% of 102 randomly located plots showed evidence of disturbance, with the severity of disturbance greatest close to trails. As a result, vegetation in 90% of the Valley has been damaged by visitor use, nearly all of it from unregulated use. These results highlight the extent to which informal trails and trampling off-trail can cause landscape damage to areas of high conservation value, and hence the importance of better regulation of visitor use. The methodology used for off-trail impact assessment can be easily applied or adapted for other popular protected areas where trampling off-trail is also an issue.

The Dynamics of Foraging Trails in the Tropical Arboreal Ant Cephalotes goniodontus

PubMed Central

Gordon, Deborah M.

2012-01-01

The foraging behavior of the arboreal turtle ant, Cephalotes goniodontus, was studied in the tropical dry forest of western Mexico. The ants collected mostly plant-derived food, including nectar and fluids collected from the edges of wounds on leaves, as well as caterpillar frass and lichen. Foraging trails are on small pieces of ephemeral vegetation, and persist in exactly the same place for 4–8 days, indicating that food sources may be used until they are depleted. The species is polydomous, occupying many nests which are abandoned cavities or ends of broken branches in dead wood. Foraging trails extend from trees with nests to trees with food sources. Observations of marked individuals show that each trail is travelled by a distinct group of foragers. This makes the entire foraging circuit more resilient if a path becomes impassable, since foraging in one trail can continue while a different group of ants forms a new trail. The colony’s trails move around the forest from month to month; from one year to the next, only one colony out of five was found in the same location. There is continual searching in the vicinity of trails: ants recruited to bait within 3 bifurcations of a main foraging trail within 4 hours. When bait was offered on one trail, to which ants recruited, foraging activity increased on a different trail, with no bait, connected to the same nest. This suggests that the allocation of foragers to different trails is regulated by interactions at the nest. PMID:23209749

A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production.

PubMed

Hasegawa, Hiroo; Yamada, Yasuaki; Komiyama, Kanki; Hayashi, Masahiko; Ishibashi, Masami; Sunazuka, Toshiaki; Izuhara, Takeshi; Sugahara, Kazuyuki; Tsuruda, Kazuto; Masuda, Masato; Takasu, Nobuyuki; Tsukasaki, Kunihiro; Tomonaga, Masao; Kamihira, Shimeru

2007-09-01

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells; however, not all human tumors respond to TRAIL, potentially limiting its therapeutic utility. Although there is substantial evidence that cytotoxic drugs can augment sensitivity to TRAIL, it has become important to know what kinds of nontoxic drugs can be used together with TRAIL. We thus screened several natural compounds that can overcome resistance to TRAIL and found that a cycloanthranilylproline derivative, Fuligocandin B (FCB), an extract of myxomycete Fuligo candida, exhibited significant synergism with TRAIL. Treatment of the TRAIL-resistant cell line KOB with FCB and TRAIL resulted in apparent apoptosis, which was not induced by either agent alone. FCB increased the production of 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), an endogenous PPAR gamma ligand, through activation of cyclooxygenase-2 (COX-2). This unique mechanism highlighted the fact that 15d-PGJ(2) directly enhanced sensitivity to TRAIL by inhibiting multiple antiapoptotic factors. More importantly, similar effects were observed in other leukemia cell lines irrespective of their origin. The enhancement was observed regardless of PPAR gamma expression and was not blocked even by peroxisome proliferator-activated receptor-gamma (PPAR gamma) siRNA. These results indicate that 15d-PGJ(2) sensitizes TRAIL-resistant cells to TRAIL in a PPAR gamma-independent manner and that the use of 15d-PGJ(2) or its inducers, such as FCB, is a new strategy for cancer therapy.

Toward the improvement of trail classification in national parks using the recreation opportunity spectrum approach.

PubMed

Oishi, Yoshitaka

2013-06-01

Trail settings in national parks are essential management tools for improving both ecological conservation efforts and the quality of visitor experiences. This study proposes a plan for the appropriate maintenance of trails in Chubusangaku National Park, Japan, based on the recreation opportunity spectrum (ROS) approach. First, we distributed 452 questionnaires to determine park visitors' preferences for setting a trail (response rate = 68 %). Respondents' preferences were then evaluated according to the following seven parameters: access, remoteness, naturalness, facilities and site management, social encounters, visitor impact, and visitor management. Using nonmetric multidimensional scaling and cluster analysis, the visitors were classified into seven groups. Last, we classified the actual trails according to the visitor questionnaire criteria to examine the discrepancy between visitors' preferences and actual trail settings. The actual trail classification indicated that while most developed trails were located in accessible places, primitive trails were located in remote areas. However, interestingly, two visitor groups seemed to prefer a well-conserved natural environment and, simultaneously, easily accessible trails. This finding does not correspond to a premise of the ROS approach, which supposes that primitive trails should be located in remote areas without ready access. Based on this study's results, we propose that creating trails, which afford visitors the opportunity to experience a well-conserved natural environment in accessible areas is a useful means to provide visitors with diverse recreation opportunities. The process of data collection and analysis in this study can be one approach to produce ROS maps for providing visitors with recreational opportunities of greater diversity and higher quality.

[Cell-penetrating chimeric apoptotic peptide AVPI-LMWP/DNA co-delivery system for cancer therapy].

PubMed

Tan, Jiao; Wang, Ya-Ping; Wang, Hui-Xin; Liang, Jian-Ming; Zhang, Meng; Sun, Xun; Huang, Yong-Zhuo

2014-12-01

To develop a cell-penetrating chimeric apoptotic peptide AVPI-LMWP/DNA co-delivery system for cancer therapy, we prepared the AVPI-LMWP/pTRAIL self-assembled complexes containing a therapeutic combination of peptide drug AVPI and DNA drug TRAIL. The chimeric apoptotic peptide AVPI-LMWP was synthesized using the standard solid-phase synthesis. The cationic AVPI-LMWP could condense pTRAIL by electrostatic interaction. The physical-chemical properties of the AVPI-LMWP/pTRAIL complexes were characterized. The cellular uptake efficiency and the inhibitory activity of the AVPI-LMWP/pTRAIL complexes on tumor cell were also performed. The results showed that the AVPI-LMWP/pTRAIL complexes were successfully prepared by co-incubation. With the increase of mass ratio (AVPI-LMWP/DNA), the particle size was decreased and the zeta potential had few change. Agarose gel electrophoresis showed that AVPI-LMWP could fully bind and condense pTRAIL at a mass ratio above 15:1. Cellular uptake efficiency was improved along with the increased ratio of W(AVPI-LMWP)/WpTRAIL. The in vitro cytotoxicity experiments demonstrated that the AVPI-LMWP/pTRAIL (W:W = 20:1) complexes was significantly more effective than the pTRAIL, AVPI-LMWP alone or LMWP/pTRAIL complexes on inhibition of HeLa cell growth. Our studies indicated that the AVPI-LMWP/pTRAIL co-delivery system could deliver plasmid into HeLa cell and induce tumor cell apoptosis efficiently, which showed its potential in cancer therapy using combination of apoptoic peptide and gene drugs.

Trail pheromones: an integrative view of their role in social insect colony organization.

PubMed

Czaczkes, Tomer J; Grüter, Christoph; Ratnieks, Francis L W

2015-01-07

Trail pheromones do more than simply guide social insect workers from point A to point B. Recent research has revealed additional ways in which they help to regulate colony foraging, often via positive and negative feedback processes that influence the exploitation of the different resources that a colony has knowledge of. Trail pheromones are often complementary or synergistic with other information sources, such as individual memory. Pheromone trails can be composed of two or more pheromones with different functions, and information may be embedded in the trail network geometry. These findings indicate remarkable sophistication in how trail pheromones are used to regulate colony-level behavior, and how trail pheromones are used and deployed at the individual level.

Hiker preferences for trail features and maps

Treesearch

Roger E. McCay

1978-01-01

Hikers at a Pennsylvania state park were asked what items were essential to their trail experience. From a list of 18 items, an overwhelming majority of hikers wanted to see trail names and directional signs along a natural surfaced trail.

The predatory mite Neoseiulus womersleyi (Acari: Phytoseiidae) follows extracts of trails left by the two-spotted spider mite Tetranychus urticae (Acari: Tetranychidae).

PubMed

Shinmen, Tsubasa; Yano, Shuichi; Osakabe, Mh

2010-10-01

As it walks, the two-spotted spider mite Tetranychus urticae Koch (Acari: Tetranychidae) spins a trail of silk threads, that is followed by the predatory mite, Neoseiulus womersleyi Schicha (Acari: Phytoseiidae). Starved adult female N. womersleyi followed T. urticae trails laid down by five T. urticae females but did not follow a trail of one T. urticae female, suggesting that the amount of spun threads and their chemical components should correlate positively with the number of T. urticae individuals. To examine whether chemical components of T. urticae trails are responsible for the predatory mite's trail following, we collected separate T. urticae threads from the exuviae and eggs, and then washed the threads with methanol to separate chemical components from physical attributes of the threads. Female N. womersleyi did not follow T. urticae trails that had been washed with methanol but contained physical residues, but they did follow the direction to which the methanol extracts of the T. urticae trails was applied. These results suggest that the predatory mite follows chemical, not physical, attributes of T. urticae trails.

Oncolytic adenovirus encoding tumor necrosis factor-related apoptosis inducing ligand (TRAIL) inhibits the growth and metastasis of triple-negative breast cancer

PubMed Central

Zhu, Wei; Zhang, Hongwei; Shi, Yi; Song, Mangen; Zhu, Bijun; Wei, Lai

2013-01-01

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising cancer therapeutic target due to its selective apoptosis-inducing effect in cancer cells. To efficiently deliver TRAIL to the tumor cells, an oncolytic adenovirus (p55-hTERT-HRE-TRAIL) carrying the TRAIL coding sequence was constructed. In the present study, we aimed to investigate the effect of p55-hTERT-HRE-TRAIL on the growth and metastasis of triple-negative breast cancer (TNBC). We observed that infection of the recombinant adenovirus resulted in expression of TRAIL and massive cell death in a TNBC cell line MDA-MB-231. This effect is much weaker in MCF-10A, which is a normal breast cell line. Administration of P55-HTERT-HRE-TRAIL significantly reduced orthotopic breast tumor growth and extended survival in a metastatic model. Our results suggest the oncolytic adenovirus armed with P55-HTERT-HRE-TRAIL, which exhibited enhanced anti-tumor activity and improved survival, is a promising candidate for virotherapy of TNBC. PMID:24025362

Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System.

PubMed

Toffoli, Barbara; Fabris, Bruno; Bartelloni, Giacomo; Bossi, Fleur; Bernardi, Stella

2016-01-01

Background . Dyslipidemia and diabetes are two of the most well established risk factors for the development of cardiovascular disease (CVD). Both of them usually activate a complex range of pathogenic pathways leading to organ damage. Here we hypothesized that dyslipidemia and diabetes could affect osteoprotegerin (OPG) and TNF-related apoptosis-inducing ligand (TRAIL) expression in the vessels and the heart. Materials and Methods . Gene and protein expression of OPG, TRAIL, and OPG/TRAIL ratio were quantified in the aorta and the hearts of control mice, dyslipidemic mice, and diabetic mice. Results . Diabetes significantly increased OPG and the OPG/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG and reduced TRAIL expression, thus increasing cardiac OPG/TRAIL ratio. Conclusions . This work shows that both dyslipidemia and diabetes affect OPG/TRAIL ratio in the cardiovascular system. This could contribute to the changes in circulating OPG/TRAIL which are observed in patients with diabetes and CVD. Most importantly, these changes could mediate/contribute to atherosclerosis development and cardiac remodeling.

Investigation of contributing factors regarding wrong-way driving on freeways, phase II.

DOT National Transportation Integrated Search

2015-09-01

In the second phase of this project, two major tasks were completed: (1) organizing a national wrong-way driving : (WWD) summit and (2) developing guidelines for reducing WWD on freeways. The first national WWD summit was : held in Edwardsville, Illi...

Senior executive transportation & public safety summit : national traffic incident management leadership & innovation roadmap for success

DOT National Transportation Integrated Search

2012-09-05

This report summarizes the proceedings, findings, and recommendations from a two-day Senior Executive Summit on Transportation and Public Safety, held June 26 and 27, 2012 at the United States Department of Transportation (USDOT) in Washington, D.C. ...

Administrator Bridenstine Speaks at Humans to Mars Summit

NASA Image and Video Library

2018-05-09

NASA Administrator Jim Bridenstine delivered the keynote address at the Humans to Mars Summit 2018, on Wednesday, May 9 at The George Washington University, in Washington. The annual event addresses the technical, scientific and policy challenges of making human exploration of Mars a reality.

Climate Controlled?

ERIC Educational Resources Information Center

Harney, John O.

2014-01-01

More than 250 higher education leaders from campuses across the U.S. met last week in Boston for the 2014 Presidential Summit on Climate Leadership. The summit was organized by Second Nature, the supporting organization for the American College & University Presidents' Climate Commitment (ACUPCC). Almost 700 colleges and universities have…

Humans to Mars Summit 2014

NASA Image and Video Library

2014-04-22

William Gerstenmaier, NASA Associatate Administrator for Human Exploration and Operations, right, answers a question during a panel discussion moderated by PBS NewsHour's Miles O'Brien at the Humans to Mars Summit on April 22, 2014 at George Washington University in Washington, DC. Photo Credit: (NASA/Joel Kowsky)

Slides from the 2013 Smart Growth Summit on How to Learn from the New Orleans Urban Waters Partnership

EPA Pesticide Factsheets

Presentation Slides for 2013 Smart Growth Summit, Baton Rouge, LA, H2O Overview: How to Learn from the New Orleans Urban Waters Partnership - Danny Wiegand Urban Waters Ambassador to New Orleans November 19, 2013

Higher Ambitions Summit. Rapporteur Report

ERIC Educational Resources Information Center

Nash, Ian

2014-01-01

The Sutton Trust and Pearson two-day summit on higher ambitions in apprenticeships and vocational education drew more than 120 leaders in education, training and employment, policy makers, academics, and researchers to London. Delegates heard from political leaders stressing the importance they attach to high-quality apprenticeships. Presentations…

Achieving transformational change: using appreciative inquiry for strategic planning in a school of nursing.

PubMed

Harmon, Rebecca Bouterie; Fontaine, Dorrie; Plews-Ogan, Margaret; Williams, Anne

2012-01-01

To achieve transformational change, a transformational approach is needed. The Appreciative Inquiry (AI) summit is a method that has been used to achieve transformational change in business for at least 20 years, but this innovative alternative approach is unknown to nursing. At the University of Virginia School of Nursing, an AI Summit was designed to bring all staff, faculty, student representatives, and members of the community together to rewrite the school's strategic plan. New connections within the school, the university, and the community were made when 135 participants engaged in the appreciative, 4-step AI process of discovering, dreaming, designing, and creating the school's future. During the summit, 7 strategic teams formed to move the school toward the best possible future while building on the existing positive core. This article describes 10 steps needed to design an AI summit and implications for using this method at other schools of nursing. Copyright © 2012 Elsevier Inc. All rights reserved.

Mock climate summit: teaching and assessing learning

NASA Astrophysics Data System (ADS)

Schweizer, D.; Gautier, C.; Bazerman, C.

2003-04-01

This paper will demonstrate the effectiveness of a Mock Climate Summit as a pedagogical approach for teaching the science and policy aspects of global climate change. The Mock Climate Summit is a student-centered course simulating the Conference of the Parties (COP) where international environmental protocols are negotiated. Compared to traditional lecture-based methods common in the geoscience classroom, the Mock Climate Summit uses negotiations and arguments to teach the interactions between these two “spheres” and demonstrate the depth and breadth of these interactions. Through a detailed assessment of students’ dialogue transcribed from video and audio tapes, we found that the nature of the student dialogue matures rapidly as they are given multiple opportunities to present, negotiate and argue a specific topic. Students’ dialogue progress from hypothetical (what-if) scenarios to action-oriented scenarios and implementation plans. The progression of the students’ dialogue shows increased comfort with the communities’ discourse as they take ownership of the point-of-view associated with their assumed roles.

Mock Climate Summit: Teaching and Assessing Learning

NASA Astrophysics Data System (ADS)

Schweizer, D.; Gautier, C.; Bazerman, C.

2003-04-01

This paper will demonstrate the effectiveness of a Mock Climate Summit as a pedagogical for teaching the science and policy aspects of global climate change. The Mock Climate Summit is a student-centered course simulating the Conference of the Parties (COP) where international environmental protocols are negotiated. Compared to traditional lecture-based methods common in the geoscience classroom, the Mock Climate Summit uses negotiations and arguments to teach the interactions between these two "spheres" and demonstrate the depth and breadth of these interactions. Through a detailed assessment of students' dialogue transcribed from video and audio tapes, we found that the nature of the student dialogue matures rapidly as they are given multiple opportunities to present, negotiate and argue a specific topic. Students' dialogue progress from hypothetical (what-if) scenarios to action-oriented scenarios and implementation plans. The progression of the students' dialogue shows increased comfort with the communities' discourse as they take ownership of the point-of-view associated with their assumed roles.

Consensus statement of the International Summit on Intellectual Disability and Dementia on valuing the perspectives of persons with intellectual disability.

PubMed

Watchman, Karen; Janicki, Matthew P; Udell, Leslie; Hogan, Mary; Quinn, Sam; Beránková, Anna

2018-01-01

The International Summit on Intellectual Disability and Dementia covered a range of issues related to dementia and intellectual disability, including the dearth of personal reflections of persons with intellectual disability affected by dementia. This article reflects on this deficiency and explores some of the personal perspectives gleaned from the literature, from the Summit attendees and from the experiences of persons with intellectual disability recorded or scribed in advance of the two-day Summit meeting. Systemic recommendations included reinforcing the value of the involvement of persons with intellectual disability in (a) research alongside removing barriers to inclusion posed by institutional/ethics review boards, (b) planning groups that establish supports for dementia and (c) peer support. Practice recommendations included (a) valuing personal perspectives in decision-making, (b) enabling peer-to-peer support models, (c) supporting choice in community-dwelling arrangements and (d) broadening availability of materials for persons with intellectual disability that would promote understanding of dementia.

The appeasement effect of a United Nations climate summit on the German public

NASA Astrophysics Data System (ADS)

Brüggemann, Michael; de Silva-Schmidt, Fenja; Hoppe, Imke; Arlt, Dorothee; Schmitt, Josephine B.

2017-11-01

The annual UN climate summits receive intense global media coverage, and as such could engage local publics around the world, stimulate debate and knowledge about climate politics, and, ultimately, mobilize people to combat climate change. Here we show that, in contrast to these hopes, although the German public were exposed to news about the 2015 Paris summit, they did not engage with it in a more active way. Comparing knowledge and attitudes before, during and after the summit using a three-wave online panel survey (quota sample, N = 1,121), we find that respondents learnt a few basic facts about the conference but they continue to lack basic background knowledge about climate policy. Trust in global climate policy increased a little, but citizens were less inclined to support a leading role for Germany in climate politics. Moreover, they were not more likely to engage personally in climate protection. These results suggest that this global media event had a modest appeasing rather than mobilizing effect.

Optimal medication dosing from suboptimal clinical examples: a deep reinforcement learning approach.

PubMed

Nemati, Shamim; Ghassemi, Mohammad M; Clifford, Gari D

2016-08-01

Misdosing medications with sensitive therapeutic windows, such as heparin, can place patients at unnecessary risk, increase length of hospital stay, and lead to wasted hospital resources. In this work, we present a clinician-in-the-loop sequential decision making framework, which provides an individualized dosing policy adapted to each patient's evolving clinical phenotype. We employed retrospective data from the publicly available MIMIC II intensive care unit database, and developed a deep reinforcement learning algorithm that learns an optimal heparin dosing policy from sample dosing trails and their associated outcomes in large electronic medical records. Using separate training and testing datasets, our model was observed to be effective in proposing heparin doses that resulted in better expected outcomes than the clinical guidelines. Our results demonstrate that a sequential modeling approach, learned from retrospective data, could potentially be used at the bedside to derive individualized patient dosing policies.

Investigations on the Aerodynamic Characteristics and Blade Excitations of the Radial Turbine with Pulsating Inlet Flow

NASA Astrophysics Data System (ADS)

Liu, Yixiong; Yang, Ce; Yang, Dengfeng; Zhang, Rui

2016-04-01

The aerodynamic performance, detailed unsteady flow and time-based excitations acting on blade surfaces of a radial flow turbine have been investigated with pulsation flow condition. The results show that the turbine instantaneous performance under pulsation flow condition deviates from the quasi-steady value significantly and forms obvious hysteretic loops around the quasi-steady conditions. The detailed analysis of unsteady flow shows that the characteristic of pulsation flow field in radial turbine is highly influenced by the pulsation inlet condition. The blade torque, power and loading fluctuate with the inlet pulsation wave in a pulse period. For the blade excitations, the maximum and the minimum blade excitations conform to the wave crest and wave trough of the inlet pulsation, respectively, in time-based scale. And toward blade chord direction, the maximum loading distributes along the blade leading edge until 20% chord position and decreases from the leading to trailing edge.

Near-wall serpentine cooled turbine airfoil

DOEpatents

Lee, Ching-Pang

2013-09-17

A serpentine coolant flow path (54A-54G) formed by inner walls (50, 52) in a cavity (49) between pressure and suction side walls (22, 24) of a turbine airfoil (20A). A coolant flow (58) enters (56) an end of the airfoil, flows into a span-wise channel (54A), then flows forward (54B) over the inner surface of the pressure side wall, then turns behind the leading edge (26), and flows back along a forward part of the suction side wall, then follows a loop (54E) forward and back around an inner wall (52), then flows along an intermediate part of the suction side wall, then flows into an aft channel (54G) between the pressure and suction side walls, then exits the trailing edge (28). This provides cooling matched to the heating topography of the airfoil, minimizes differential thermal expansion, revives the coolant, and minimizes the flow volume needed.

Study on Trailing Edge Ramp of Supercritical Airfoil

DTIC Science & Technology

2016-03-30

7 th Asia-Pacific International Symposium on Aerospace Technology, 25 – 27 November 2015, Cairns Study on Trailing Edge Ramp of Supercritical...China Abstract Trailing edge flow control method could improve the performance of supercritical airfoil with a small modification on the original...airfoil. In this paper, a ramp of 2%~7% chord length is sliced near the trailing edge to improve airfoil performance. The trailing edge ramp is

A mixed-modes approach for estimating hiking on trails through diverse forest landscapes: the case of the Appalachian Trail

Treesearch

Stanley J. Zarnoch; J.M. Bowker; H. Ken Cordell

2011-01-01

Many hiking trails traverse the forests and public lands across North America. It has therefore become important for federal management to gain an understanding of total use on these trails. However, there has never been a formal attempt to estimate hiking on these long, backcountry trails. This paper presents an approach that utilizes two survey instruments (exit-site...

Upward migration of the explosion sources at Sakurajima volcano, Japan, revield by a seismic network in the close vocinity of the summit crater

NASA Astrophysics Data System (ADS)

Ohminato, T.; Kaneko, T.; Koyama, T.; Watanabe, A.; Takeo, M.; Iguchi, M.

2011-12-01

Observations in the vicinity of summit area of active volcanoes are important not only for understanding physical processes in the volcanic conduit but also for eruption prediction and volcanic hazards mitigation. It is, however, challenging to install observation sensors near active vents because of the danger of sudden eruptions. We have been developing a volcano observation system based on an unmanned aerial vehicle (UAV) for safe observations near active volcanic vents. We deployed an unmanned autonomous helicopter which can aviate autonomously along a previously programmed path within a meter accuracy using real-time kinematics differential GPS equipment. The maximum flight time, flight distance, and payload are 90 minutes, 5km, and 10kg, respectively. By using the UAV, we installed seismic stations at the summit area of Sakurajima volcano, Japan. Since 2006, explosive eruptions have been continuing at the reopened Showa crater at the eastern flank near the summit of Sakurajima. Entering the area within 2 km from the active craters is prohibited, and thus there were no observation station in the summit area. From November 2nd to 12th, 2009, and from November 2nd to 12th, 2010, we conducted seismic station installation in Sakurajima summit area using UAV and successfully installed four seismic stations within 2km from the active craters. Since the installation of the seismic stations, we have succeeded in acquiring waveform data accompanying more than 500 moderate eruptions at Showa-crater. Except for the mechanical resonance contamination at 35Hz, the recorded waveforms are as good as that recorded at permanent stations in Sakurajima. Since the beginning of the observation in the vicinity of the summit crater, the normalized amplitudes of the signals accompanying eruptions at Showa crater had been almost steady. However, after early April 2011, gradual increase of the normalized amplitude started, and this increasing trend is continuing at the time of the abstract submission. This increasing trend of the normalized amplitude strongly suggests upward migration of the source of the explosive eruptions at Showa-crater. The upward migration may suggest further intensification of the activity of Sakurajima in the near future.

Summit Lake landslide and geomorphic history of Summit Lake basin, northwestern Nevada

USGS Publications Warehouse

Curry, B. Brandon; Melhorn, W.N.

1990-01-01

The Summit Lake landslide, northwestern Nevada, composed of Early Miocene pyroclastic debris, Ashdown Tuff, and basalt and rhyolite of the Black Rock Range, blocked the upper Soldier Creek-Snow Creek drainage and impounded Summit Lake sometimes prior to 7840 yr B.P. The slide covers 8.2 km2 and has geomorphic features characteristic of long run-out landslides, such as lobate form, longitudinal and transverse ridges, low surface gradient (7.1 ??), and preservation of original stratigraphic position of transported blocks. However, estimated debris volume is the smallest reported (2.5 ?? 105 m3) for a landslide of this type. The outflow channel of the Summit Lake basin was a northward-flowing stream valley entrenched by Mahogany Creek. Subsequent negative tectonic adjustment of the basin by about 35 m, accompanied by concommitant progradation of a prominent alluvial fan deposited by Mahogany Creek, argues for a probable diversion of drainage from the Alvord basin southward into the Lahontan basin. The landslide occurred while the creek flowed southward, transferring about 147 km2 of watershed from the Lahontan basin back to the Alvord basin. Overflow northward occurred during high stands of Pluvial Lake Parman in the basin; otherwise, under drier climates, the Summit Lake basin has been closed. Within large depressions on the slide surface, the ca. 6800 yr old Mazama Bed and other sediments have buried a weakly developed soil. Disseminated humus in the soil yields an age of 7840 ?? 310 yr B.P. Absence of older tephra (such as St. Helens M) brackets the slide age between 7840 and 19,000 yr B.P. Projectile points found on the highest strandlines of Pluvial Lake Parman suggest a ca 8700 yr B.P. age by correlation with cultural artifacts and radiocarbon ages from nearby Last Supper Cave, Nevada. Organic matter accumulation in landslide soils suggests ages ranging from 9100 to 16,250 yr B.P. Estimation of the age of the slide from morphologic data for the isolated Summit Lake population of Lahontan cutthroat trout does not conflict with the radiometric ages. ?? 1990.

The contribution of atmospheric proxies to the vertical distribution of ozone over Summit Station, Greenland

NASA Astrophysics Data System (ADS)

Bahramvash Shams, S.; Walden, V. P.; Oltmans, S. J.; Petropavlovskikh, I. V.; Kivi, R.; Thölix, L.

2017-12-01

The current trend and future concentrations of atmospheric ozone are active areas of research as the effect of the Montreal Protocol is realized. The trend of ozone is due to various chemical and dynamical parameters that create, destroy, and transport atmospheric ozone. These important parameters can be represented by different proxies, but their effects on ozone concentration are not completely understood. Previous studies show that proxies related to ozone have different contributions depending on latitude and altitude. In this study, we use vertical profiles of ozone derived from ozonesondes launched by the NOAA Global Monitoring Division at Summit Station, Greenland from 2005 to 2016. The effects of different proxies on ozone are investigated. Summit Station is located at 3,200 meters above sea level on the Greenland Ice Sheet and is a unique place in the Arctic. We use a stepwise multiple regression (MLR) technique to remove the seasonal cycle of ozone and investigate how the different proxies [solar flux (SF), the Quasi-Biennial Oscillation (QBO), the El Nino-Southern Oscillation index (ENSO), the Arctic Oscillation (AO), eddy heat flux (EHF), the volume of polar stratospheric clouds (VPSC), equivalent latitude (EL), and the tropopause pressure (TP)] affect the vertical distribution of ozone over Summit. The MLR is applied separately to total column ozone (TCO) as well as partial ozone columns (PCO) in the troposphere and the lower, middle, and upper stratosphere. Our results show that dynamical processes are important contributors to ozone concentrations over Summit Station. Tropospheric pressure and the QBO are effective predictors of ozone in the troposphere, lower and middle stratosphere, and to the TCO. The VPSC is an important contributor to changes in ozone in the middle stratosphere. AO explains part of low/mid stratospheric and TCO ozone cycle. A simulation model of ozone over Summit built from the MLR results explains the seasonal cycle and the trends in TCO over Summit with a correlation coefficient (R2) of 82% for TCO. Simulations of PCO in the lower and middle stratosphere range from R2 = 62% to 85%.

Female Sex Pheromone in Trails of the Minute Pirate Bug, Orius minutus (L).

PubMed

Maeda, Taro; Fujiwara-Tsujii, Nao; Yasui, Hiroe; Matsuyama, Shigeru

2016-05-01

Orius minutus (L.) (Heteroptera: Anthocoridae) is a natural enemy of agricultural pests such as thrips, aphids, and various newly hatched insect juveniles. In this study, we conducted 1) behavioral assays for evidence of contact sex pheromone activity in trails of O. minutus, and 2) chemical analysis to identify the essential chemical components of the trails. Males showed arrestment to trails of mature virgin females but not to trails from either conspecific nymphs or immature females. Females also showed arrestment to trails from conspecific males, although the response was weaker than that exhibited by males. The activity of female trails lasted for at least 46 h after deposition. Males showed a response irrespective of mating experience. Following confirmation that a contact sex pheromone was present in the trails of female O. minutus, we used a bioassay-driven approach to isolate the active chemicals. After fractionation on silica gel, the n-hexane fraction was found to be biologically active to males. A major compound in the active fraction was (Z)-9-nonacosene; this compound was found only in trail extracts of mature virgin females. Synthetic (Z)-9-nonacosene arrested O. minutus males, indicating that it is the major active component of the contact sex pheromone in the trails of female O. minutus.

Mitochondria-dependent and -independent mechanisms in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis are both regulated by interferon-gamma in human breast tumour cells.

PubMed Central

Ruiz-Ruiz, Carmen; López-Rivas, Abelardo

2002-01-01

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL/APO-2L) induces apoptosis in a variety of tumour cells upon binding to death receptors TRAIL-R1 and TRAIL-R2. Here we describe the sensitization by interferon (IFN)-gamma to TRAIL-induced apoptosis in the breast tumour cell lines MCF-7 and MDA-MB231. IFN-gamma promoted TRAIL-mediated activation of caspase-8, Bcl-2 interacting domain death agonist (Bid) degradation, Bcl-2-associated X protein (Bax) translocation to mitochondria, cytochrome c release to the cytosol and activation of caspase-9 in these cell lines. No changes in the expression of TRAIL receptors were observed upon IFN-gamma treatment. Overexpression of Bcl-2 in MCF-7 cells completely inhibited IFN-gamma-induced sensitization to TRAIL-mediated cell death. Interestingly, TRAIL-induced apoptosis was also clearly enhanced by IFN-gamma in caspase-3-overexpressing MCF-7 cells, in the absence of Bax translocation to mitochondria and cytochrome c release to the cytosol. In summary, our results suggest that IFN-gamma facilitates TRAIL-induced activation of mitochondria-regulated as well as mitochondria-independent apoptotic pathways in breast tumour cells. PMID:11936954

Trail impact monitoring in Rocky Mountain National Park, USA

NASA Astrophysics Data System (ADS)

Svajda, J.; Korony, S.; Brighton, I.; Esser, S.; Ciapala, S.

2016-01-01

This paper examines impacts of increased visitation leading to human trampling of vegetation and soil along several trails in Rocky Mountain National Park (RMNP) to understand how abiotic factors and level of use can influence trail conditions. RMNP is one of the most visited national parks in the USA, with 3.3 million visitors in 2012 across 1075 km2 and 571 km of hiking trails. 95 % of the park is designated wilderness, making the balance between preservation and visitor use challenging. This research involves the application of trail condition assessments to 56 km of trails to determine prevailing factors and what, if any, connection between them exist. The study looked at a variety of inventory and impact indicators and standards to determine their importance and to develop a baseline condition of trails. The data can be used for future comparison and evaluation of development trends. We found that trail widening (mean trail width 88.9 cm) and soil loss (cross-sectional area 172.7 cm2) are the most visible effects of trail degradation. Further statistical analyses of data identified the role and influence of various factors (e.g., use level and topography). Insights into the influence of these factors can lead to the selection of appropriate management measures to avoid or minimize negative consequences from increased visitation.

Trail impact monitoring in Rocky Mountain National Park, USA

NASA Astrophysics Data System (ADS)

Svajda, J.; Korony, S.; Brighton, I.; Esser, S.; Ciapala, S.

2015-11-01

This paper examines impacts of increased visitation leading to human trampling of vegetation and soil along several trails in Rocky Mountain National Park (RMNP) to understand how abiotic factors and level of use can influence trail conditions. RMNP is one of the most visited national parks in the USA with 3.3 million visitors in 2012 across 1075 km2 and 571 km of hiking trails. 95 % of the park is designated wilderness making the balance between preservation and visitor use challenging. This research involves the application of trail condition assessments to 56 km of trails to determine prevailing factors and what, if any, connection between them exist. The study looked at a variety of inventory and impact indicators and standards to determine their importance and to develop a baseline condition of trails. The data can be used for future comparison and evaluation of development trends. We found that trail widening (mean trail width 88.9 cm) and soil loss (cross sectional area 172.7 cm2) are the most visible effects of trail degradation. Further statistical analyses of data identified the role and influence of various factors (e.g. use level and topography). Insights into the influence of these factors can lead to the selection of appropriate management measures to avoid or minimize negative consequences from increased visitation.

Alzheimer's Disease-Related Dementias Summit 2016: National research priorities.

PubMed

Corriveau, Roderick A; Koroshetz, Walter J; Gladman, Jordan T; Jeon, Sophia; Babcock, Debra; Bennett, David A; Carmichael, S Thomas; Dickinson, Susan L-J; Dickson, Dennis W; Emr, Marian; Fillit, Howard; Greenberg, Steven M; Hutton, Michael L; Knopman, David S; Manly, Jennifer J; Marder, Karen S; Moy, Claudia S; Phelps, Creighton H; Scott, Paul A; Seeley, William W; Sieber, Beth-Anne; Silverberg, Nina B; Sutherland, Margaret L; Taylor, Angela; Torborg, Christine L; Waddy, Salina P; Gubitz, Amelie K; Holtzman, David M

2017-12-05

Goal 1 of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease-related dementias by 2025. To help inform the research agenda toward achieving this goal, the NIH hosts periodic summits that set and refine relevant research priorities for the subsequent 5 to 10 years. This proceedings article summarizes the 2016 Alzheimer's Disease-Related Dementias Summit, including discussion of scientific progress, challenges, and opportunities in major areas of dementia research, including mixed-etiology dementias, Lewy body dementia, frontotemporal degeneration, vascular contributions to cognitive impairment and dementia, dementia disparities, and dementia nomenclature. © 2017 American Academy of Neurology.

2012 ARPA-E Energy Innovation Summit Keynote Presentation (Bill Clinton, 42nd President of the United States)

ScienceCinema

Clinton, William J.

2018-05-03

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Former President Bill Clinton, the 42nd President of the United States, gave the final keynote address of the 2012 Summit on February 29. He addressed the importance of government investment in research that will help move the world toward a cleaner and more secure energy future.

2012 ARPA-E Energy Innovation Summit Keynote Presentation (Bill Clinton, 42nd President of the United States)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clinton, William J.

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Former President Bill Clinton, the 42nd President of the United States, gave the final keynote address of the 2012 Summit on February 29. He addressed the importance of government investment in research that will help move the world toward a cleaner and more secure energy future.

Earth Summit Science, policy discussed

NASA Astrophysics Data System (ADS)

Leath, Audrey T.

The United Nations Conference on Environment and Development, the “Earth Summit,” convenes in Rio de Janeiro on June 3. President Bush has pledged to attend part of the 2-week conference. The highlight of the summit will be the signing of an international framework convention to reduce emissions of greenhouse gases. The final elements of the agreement were negotiated in New York last week by representative of 143 countries. In anticipation of the Rio conference, the Senate Committee on Energy and Natural Resources held two standing-roomonly hearings, reviewing the scientific basis for global warming due to greenhouse gases and discussing the details of the proposed convention.

Rehabilitation Medicine Summit: Building Research Capacity

PubMed Central

Frontera, Walter R; Fuhrer, Marcus J; Jette, Alan M; Chan, Leighton; Cooper, Rory A; Duncan, Pamela W; Kemp, John D; Ottenbacher, Kenneth J; Peckham, P Hunter; Roth, Elliot J; Tate, Denise G

2006-01-01

Summary: The general objective of the “Rehabilitation Medicine Summit: Building Research Capacity” was to advance and promote research in medical rehabilitation by making recommendations to expand research capacity. The five elements of research capacity that guided the discussions were: 1) researchers; 2) research culture, environment, and infrastructure; 3) funding; 4) partnerships; and 5) metrics. The 100 participants included representatives of professional organizations, consumer groups, academic departments, researchers, governmental funding agencies, and the private sector. The small group discussions and plenary sessions generated an array of problems, possible solutions, and recommended actions. A post-Summit, multi-organizational initiative is called to pursue the agendas outlined in this report. PMID:16572568

The impact of glide phases on the trackability of hydrodynamic trails in harbour seals (Phoca vitulina).

PubMed

Wieskotten, S; Dehnhardt, G; Mauck, B; Miersch, L; Hanke, W

2010-11-01

The mystacial vibrissae of harbour seals (Phoca vitulina) constitute a highly sensitive hydrodynamic receptor system enabling the seals to detect and follow hydrodynamic trails. In the wild, hydrodynamic trails, as generated by swimming fish, consist of cyclic burst-and-glide phases, associated with various differences in the physical parameters of the trail. Here, we investigated the impact of glide phases on the trackability of differently aged hydrodynamic trails in a harbour seal. As fish are not easily trained to swim certain paths with predetermined burst-and-glide phases, the respective hydrodynamic trails were generated using a remote-controlled miniature submarine. Gliding phases in hydrodynamic trails had a negative impact on the trackability when trails were 15 s old. The seal lost the generated trails more often within the transition zones, when the submarine switched from a burst to a glide moving pattern. Hydrodynamic parameter analysis (particle image velocimetry) revealed that the smaller dimensions and faster decay of hydrodynamic trails generated by the gliding submarine are responsible for the impaired success of the seal tracking the gliding phase. Furthermore, the change of gross water flow generated by the submarine from a rearwards-directed stream in the burst phase to a water flow passively dragged behind the submarine during gliding might influence the ability of the seal to follow the trail as this might cause a weaker deflection of the vibrissae. The possible ecological implications of intermittent swimming behaviour in fish for piscivorous predators are discussed.

CSX rail trestle conversion to ATV trail.

DOT National Transportation Integrated Search

2014-10-01

The Hatfield and McCoy Trail Authority (HMRRA) operates the Rockhouse ATV trail : between Man and Gilbert WV. Prior to this project, trail riders wishing to cross the Guyandotte : River had to ride the streets of Man, WV. The project goal was to prom...

A trail pheromone component of the ant Mayriella overbecki Viehmeyer (Formicidae: Myrmicinae)

NASA Astrophysics Data System (ADS)

Kohl, E.; Hölldobler, B.; Bestmann, H.-J.

The myrmicine ant Mayriella overbecki lays recruitment trails during foraging and nest emigrations. The trail pheromone originates from the poison gland. From ten identified components of the poison gland secretions only methyl 6-methylsalicylate 1 elicited trail following behavior.