Combining multi-atlas segmentation with brain surface estimation

NASA Astrophysics Data System (ADS)

Huo, Yuankai; Carass, Aaron; Resnick, Susan M.; Pham, Dzung L.; Prince, Jerry L.; Landman, Bennett A.

2016-03-01

Whole brain segmentation (with comprehensive cortical and subcortical labels) and cortical surface reconstruction are two essential techniques for investigating the human brain. The two tasks are typically conducted independently, however, which leads to spatial inconsistencies and hinders further integrated cortical analyses. To obtain self-consistent whole brain segmentations and surfaces, FreeSurfer segregates the subcortical and cortical segmentations before and after the cortical surface reconstruction. However, this "segmentation to surface to parcellation" strategy has shown limitation in various situations. In this work, we propose a novel "multi-atlas segmentation to surface" method called Multi-atlas CRUISE (MaCRUISE), which achieves self-consistent whole brain segmentations and cortical surfaces by combining multi-atlas segmentation with the cortical reconstruction method CRUISE. To our knowledge, this is the first work that achieves the reliability of state-of-the-art multi-atlas segmentation and labeling methods together with accurate and consistent cortical surface reconstruction. Compared with previous methods, MaCRUISE has three features: (1) MaCRUISE obtains 132 cortical/subcortical labels simultaneously from a single multi-atlas segmentation before reconstructing volume consistent surfaces; (2) Fuzzy tissue memberships are combined with multi-atlas segmentations to address partial volume effects; (3) MaCRUISE reconstructs topologically consistent cortical surfaces by using the sulci locations from multi-atlas segmentation. Two data sets, one consisting of five subjects with expertly traced landmarks and the other consisting of 100 volumes from elderly subjects are used for validation. Compared with CRUISE, MaCRUISE achieves self-consistent whole brain segmentation and cortical reconstruction without compromising on surface accuracy. MaCRUISE is comparably accurate to FreeSurfer while achieving greater robustness across an elderly population.

Combining Multi-atlas Segmentation with Brain Surface Estimation.

PubMed

Huo, Yuankai; Carass, Aaron; Resnick, Susan M; Pham, Dzung L; Prince, Jerry L; Landman, Bennett A

2016-02-27

Whole brain segmentation (with comprehensive cortical and subcortical labels) and cortical surface reconstruction are two essential techniques for investigating the human brain. The two tasks are typically conducted independently, however, which leads to spatial inconsistencies and hinders further integrated cortical analyses. To obtain self-consistent whole brain segmentations and surfaces, FreeSurfer segregates the subcortical and cortical segmentations before and after the cortical surface reconstruction. However, this "segmentation to surface to parcellation" strategy has shown limitations in various situations. In this work, we propose a novel "multi-atlas segmentation to surface" method called Multi-atlas CRUISE (MaCRUISE), which achieves self-consistent whole brain segmentations and cortical surfaces by combining multi-atlas segmentation with the cortical reconstruction method CRUISE. To our knowledge, this is the first work that achieves the reliability of state-of-the-art multi-atlas segmentation and labeling methods together with accurate and consistent cortical surface reconstruction. Compared with previous methods, MaCRUISE has three features: (1) MaCRUISE obtains 132 cortical/subcortical labels simultaneously from a single multi-atlas segmentation before reconstructing volume consistent surfaces; (2) Fuzzy tissue memberships are combined with multi-atlas segmentations to address partial volume effects; (3) MaCRUISE reconstructs topologically consistent cortical surfaces by using the sulci locations from multi-atlas segmentation. Two data sets, one consisting of five subjects with expertly traced landmarks and the other consisting of 100 volumes from elderly subjects are used for validation. Compared with CRUISE, MaCRUISE achieves self-consistent whole brain segmentation and cortical reconstruction without compromising on surface accuracy. MaCRUISE is comparably accurate to FreeSurfer while achieving greater robustness across an elderly population.

Thermally cleavable surfactants

DOE Office of Scientific and Technical Information (OSTI.GOV)

McElhanon, James R; Simmons, Blake A; Zifer, Thomas

2009-11-24

Two new surfactant molecules are reported which contain thermally labile Diels-Alder adducts connecting the polar and non-polar sections of each molecule. The two surfactants possess identical non-polar dodecyl tail segments but exhibit different polar headgroups. The surfactants become soluble in water when anionic salts are formed through the deprotonation of the surfactant headgroups by the addition of potassium hydroxide. When either surfactant is exposed to temperature above about 60.degree. C., the retro Diels-Alder reaction occurs, yielding hydrophilic and hydrophobic fragments or the aqueous solutions of the surfactants subsequently exhibit loss of all surface-active behavior.

Thermally cleavable surfactants

DOE Office of Scientific and Technical Information (OSTI.GOV)

McElhanon, James R; Simmons, Blake A; Zifer, Thomas

2009-09-29

Two new surfactant molecules are reported which contain thermally labile Diels-Alder adducts connecting the polar and non-polar sections of each molecule. The two surfactants possess identical non-polar dodecyl tail segments but exhibit different polar headgroups. The surfactants become soluble in water when anionic salts are formed through the deprotonation of the surfactant headgroups by the addition of potassium hydroxide. When either surfactant is exposed to temperature above about 60.degree. C., the retro Diels-Alder reaction occurs, yielding hydrophilic and hydrophobic fragments or the aqueous solutions of the surfactants subsequently exhibit loss of all surface-active behavior.

Thermally cleavable surfactants

DOEpatents

McElhanon, James R [Manteca, CA; Simmons, Blake A [San Francisco, CA; Zifer, Thomas [Manteca, CA; Jamison, Gregory M [Albuquerque, NM; Loy, Douglas A [Albuquerque, NM; Rahimian, Kamyar [Albuquerque, NM; Long, Timothy M [Urbana, IL; Wheeler, David R [Albuquerque, NM; Staiger, Chad L [Albuquerque, NM

2006-04-04

Two new surfactant molecules are reported which contain thermally labile Diels-Alder adducts connecting the polar and non-polar sections of each molecule. The two surfactants possess identical non-polar dodecyl tail segments but exhibit different polar headgroups. The surfactants become soluble in water when anionic salts are formed through the deprotonation of the surfactant headgroups by the addition of potassium hydroxide. When either surfactant is exposed to temperature above about 60.degree. C., the retro Diels-Alder reaction occurs, yielding hydrophilic and hydrophobic fragments and the aqueous solutions of the surfactants subsequently exhibit loss of all surface-active behavior.

The 2011 Mw 7.1 Van (Eastern Turkey) earthquake

USGS Publications Warehouse

Elliot, John R.; Copley, Alex C.; Holley, R.; Scharer, Katherine M.; Parsons, Barry

2013-01-01

We use interferometric synthetic aperture radar (InSAR), body wave seismology, satellite imagery, and field observations to constrain the fault parameters of the Mw 7.1 2011 Van (Eastern Turkey) reverse-slip earthquake, in the Turkish-Iranian plateau. Distributed slip models from elastic dislocation modeling of the InSAR surface displacements from ENVISAT and COSMO-SkyMed interferograms indicate up to 9 m of reverse and oblique slip on a pair of en echelon NW 40 °–54 ° dipping fault planes which have surface extensions projecting to just 10 km north of the city of Van. The slip remained buried and is relatively deep, with a centroid depth of 14 km, and the rupture reaching only within 8–9 km of the surface, consistent with the lack of significant ground rupture. The up-dip extension of this modeled WSW striking fault plane coincides with field observations of weak ground deformation seen on the western of the two fault segments and has a dip consistent with that seen at the surface in fault gouge exposed in Quaternary sediments. No significant coseismic slip is found in the upper 8 km of the crust above the main slip patches, except for a small region on the eastern segment potentially resulting from the Mw 5.9 aftershock on the same day. We perform extensive resolution tests on the data to confirm the robustness of the observed slip deficit in the shallow crust. We resolve a steep gradient in displacement at the point where the planes of the two fault segments ends are inferred to abut at depth, possibly exerting some structural control on rupture extent.

Automated segmentation of blood-flow regions in large thoracic arteries using 3D-cine PC-MRI measurements.

PubMed

van Pelt, Roy; Nguyen, Huy; ter Haar Romeny, Bart; Vilanova, Anna

2012-03-01

Quantitative analysis of vascular blood flow, acquired by phase-contrast MRI, requires accurate segmentation of the vessel lumen. In clinical practice, 2D-cine velocity-encoded slices are inspected, and the lumen is segmented manually. However, segmentation of time-resolved volumetric blood-flow measurements is a tedious and time-consuming task requiring automation. Automated segmentation of large thoracic arteries, based solely on the 3D-cine phase-contrast MRI (PC-MRI) blood-flow data, was done. An active surface model, which is fast and topologically stable, was used. The active surface model requires an initial surface, approximating the desired segmentation. A method to generate this surface was developed based on a voxel-wise temporal maximum of blood-flow velocities. The active surface model balances forces, based on the surface structure and image features derived from the blood-flow data. The segmentation results were validated using volunteer studies, including time-resolved 3D and 2D blood-flow data. The segmented surface was intersected with a velocity-encoded PC-MRI slice, resulting in a cross-sectional contour of the lumen. These cross-sections were compared to reference contours that were manually delineated on high-resolution 2D-cine slices. The automated approach closely approximates the manual blood-flow segmentations, with error distances on the order of the voxel size. The initial surface provides a close approximation of the desired luminal geometry. This improves the convergence time of the active surface and facilitates parametrization. An active surface approach for vessel lumen segmentation was developed, suitable for quantitative analysis of 3D-cine PC-MRI blood-flow data. As opposed to prior thresholding and level-set approaches, the active surface model is topologically stable. A method to generate an initial approximate surface was developed, and various features that influence the segmentation model were evaluated. The active surface segmentation results were shown to closely approximate manual segmentations.

Simultaneous segmentation of the bone and cartilage surfaces of a knee joint in 3D

NASA Astrophysics Data System (ADS)

Yin, Y.; Zhang, X.; Anderson, D. D.; Brown, T. D.; Hofwegen, C. Van; Sonka, M.

2009-02-01

We present a novel framework for the simultaneous segmentation of multiple interacting surfaces belonging to multiple mutually interacting objects. The method is a non-trivial extension of our previously reported optimal multi-surface segmentation. Considering an example application of knee-cartilage segmentation, the framework consists of the following main steps: 1) Shape model construction: Building a mean shape for each bone of the joint (femur, tibia, patella) from interactively segmented volumetric datasets. Using the resulting mean-shape model - identification of cartilage, non-cartilage, and transition areas on the mean-shape bone model surfaces. 2) Presegmentation: Employment of iterative optimal surface detection method to achieve approximate segmentation of individual bone surfaces. 3) Cross-object surface mapping: Detection of inter-bone equidistant separating sheets to help identify corresponding vertex pairs for all interacting surfaces. 4) Multi-object, multi-surface graph construction and final segmentation: Construction of a single multi-bone, multi-surface graph so that two surfaces (bone and cartilage) with zero and non-zero intervening distances can be detected for each bone of the joint, according to whether or not cartilage can be locally absent or present on the bone. To define inter-object relationships, corresponding vertex pairs identified using the separating sheets were interlinked in the graph. The graph optimization algorithm acted on the entire multiobject, multi-surface graph to yield a globally optimal solution. The segmentation framework was tested on 16 MR-DESS knee-joint datasets from the Osteoarthritis Initiative database. The average signed surface positioning error for the 6 detected surfaces ranged from 0.00 to 0.12 mm. When independently initialized, the signed reproducibility error of bone and cartilage segmentation ranged from 0.00 to 0.26 mm. The results showed that this framework provides robust, accurate, and reproducible segmentation of the knee joint bone and cartilage surfaces of the femur, tibia, and patella. As a general segmentation tool, the developed framework can be applied to a broad range of multi-object segmentation problems.

Tectono-stratigraphic evolution of normal fault zones: Thal Fault Zone, Suez Rift, Egypt

NASA Astrophysics Data System (ADS)

Leppard, Christopher William

The evolution of linkage of normal fault populations to form continuous, basin bounding normal fault zones is recognised as an important control on the stratigraphic evolution of rift-basins. This project aims to investigate the temporal and spatial evolution of normal fault populations and associated syn-rift deposits from the initiation of early-formed, isolated normal faults (rift-initiation) to the development of a through-going fault zone (rift-climax) by documenting the tectono-stratigraphic evolution of the Sarbut EI Gamal segment of the exceptionally well-exposed Thai fault zone, Suez Rift, Egypt. A number of dated stratal surfaces mapped around the syn-rift depocentre of the Sarbut El Gamal segment allow constraints to be placed on the timing and style of deformation, and the spatial variability of facies along this segment of the fault zone. Data collected indicates that during the first 3.5 My of rifting the structural style was characterised by numerous, closely spaced, short (< 3 km), low displacement (< 200 m) synthetic and antithetic normal faults within 1 - 2 km of the present-day fault segment trace, accommodating surface deformation associated with the development of a fault propagation monocline above the buried, pre-cursor strands of the Sarbut El Gamal fault segment. The progressive localisation of displacement onto the fault segment during rift-climax resulted in the development of a major, surface-breaking fault 3.5 - 5 My after the onset of rifting and is recorded by the death of early-formed synthetic and antithetic faults up-section, and thickening of syn-rift strata towards the fault segment. The influence of intrabasinal highs at the tips of the Sarbut EI Gamal fault segment on the pre-rift sub-crop level, combined with observations from the early-formed structures and coeval deposits suggest that the overall length of the fault segment was fixed from an early stage. The fault segment is interpreted to have grown through rapid lateral propagation and early linkage of the precursor fault strands at depth before the fault segment broke surface, followed by the accumulation of displacement on the linked fault segment with minimal lateral propagation. This style of fault growth contrasts conventional fault growth models by which growth occurs through incremental increases in both displacement and length through time. The evolution of normal fault populations and fault zones exerts a first- order control on basin physiography and sediment supply, and therefore, the architecture and distribution of coeval syn-rift stratigraphy. The early syn-rift continental, Abu Zenima Formation, to shallow marine, Nukhul Formation show a pronounced westward increase in thickness controlled by the series of synthetic and antithetic faults up to 3 km west of present day Thai fault. The orientation of these faults controlled the location of fluvial conglomerates, sandstones and mudstones that shifted to the topographic lows created. The progressive localisation of displacement onto the Sarbut El Gamal fault segment during rift-climax resulted in an overall change in basin geometry. Accelerated subsidence rates led to sedimentation rates being outpaced by subsidence resulting in the development of a marine, sediment-starved, underfilled hangingwall depocentre characterised by slope-to-basinal depositional environments, with a laterally continuous slope apron in the immediate hangingwall, and point-sourced submarine fans. Controls on the spatial distribution, three dimensional architecture, and facies stacking patterns of coeval syn-rift deposits are identified as: I) structural style of the evolution and linkage of normal fault populations, ii) basin physiography, iii) evolution of drainage catchments, iv) bedrock lithology, and v) variations in sea/lake level.

Fluidized bed boiler having a segmented grate

DOEpatents

Waryasz, Richard E.

1984-01-01

A fluidized bed furnace (10) is provided having a perforate grate (9) within a housing which supports a bed of particulate material including some combustibles. The grate is divided into a plurality of segments (E2-E6, SH1-SH5, RH1-RH5), with the airflow to each segment being independently controlled. Some of the segments have evaporating surface imbedded in the particulate material above them, while other segments are below superheater surface or reheater surface. Some of the segments (E1, E7) have no surface above them, and there are ignitor combustors (32, 34) directed to fire into the segments, for fast startup of the furnace without causing damage to any heating surface.

Nylon and teflon scribe effect on NBR to Chemlok 233 and NBR to NBR bond interfaces

NASA Technical Reports Server (NTRS)

Jensen, S. K.

1990-01-01

A study was requested by Manufacturing Engineering to determine what effects marking with nylon (6/6) and Teflon scribes may have on subsequent bonding. Witness panel bond specimens were fabricated by the development lab to test both acrylonitrile butadiene rubber (NBR) to Chemlok and NBR to NBR after controlled exposure. The nylon rod used as a scribe tool demonstrates virtually no bond deterioration when used to scribe lines on either the Chemlok to NBR surfaces or the NBR to NBR interface. Lab test results indicate that the nylon rod-exposed samples produce tensile and peel values very similar to the control samples and the Teflon exposed samples produce tensile and peel values much lower than the control samples. Visual observation of the failure surfaces of the tested samples shows that Teflon scribing produces an obvious contamination to the surface and the nylon produces no effect. Photographs of test samples are provided. It is concluded that Teflon stock used as a scribe tool on a Chemlok 233 to NBR surface or an NBR to NBR surface has a detrimental effect on the bond integrity on either of these bond interfaces. Therefore, it is recommended that the nylon rod continue to be used where a scribe line is required in the redesigned solid rocket motor segment insulation layup operations. The use of Teflon scribes should not be considered.

An evaluation of two types of nickel-titanium wires in terms of micromorphology and nickel ions' release following oral environment exposure.

PubMed

Ghazal, Abdul Razzak A; Hajeer, Mohammad Y; Al-Sabbagh, Rabab; Alghoraibi, Ibrahim; Aldiry, Ahmad

2015-01-01

This study aimed to compare superelastic and heat-activated nickel-titanium orthodontic wires' surface morphology and potential release of nickel ions following exposure to oral environment conditions. Twenty-four 20-mm-length distal cuts of superelastic (NiTi Force I®) and 24 20-mm-length distal cuts of heat-activated (Therma-Ti Lite®) nickel-titanium wires (American Orthodontics, Sheboygan, WI, USA) were divided into two equal groups: 12 wire segments left unused and 12 segments passively exposed to oral environment for 1 month. Scanning electron microscopy and atomic force microscopy were used to analyze surface morphology of the wires which were then immersed in artificial saliva for 1 month to determine potential nickel ions' release by means of atomic absorption spectrophotometer. Heat-activated nickel-titanium (NiTi) wires were rougher than superelastic wires, and both types of wires released almost the same amount of Ni ions. After clinical exposure, more surface roughness was recorded for superelastic NiTi wires and heat-activated NiTi wires. However, retrieved superelastic NiTi wires released less Ni ions in artificial saliva after clinical exposure, and the same result was recorded regarding heat-activated wires. Both types of NiTi wires were obviously affected by oral environment conditions; their surface roughness significantly increased while the amount of the released Ni ions significantly declined.

Constitutive exposure of phosphatidylserine on viable cells

PubMed Central

Segawa, Katsumori; Suzuki, Jun; Nagata, Shigekazu

2011-01-01

Apoptotic cells are quickly recognized and engulfed by phagocytes to prevent the release of noxious materials from dying cells. Phosphatidylserine (PS) exposed on the surface of apoptotic cells is a proposed “eat-me” signal for the phagocytes. Transmembrane protein 16F (TMEM16F), a membrane protein with eight transmembrane segments, has the Ca-dependent phospholipid scramblase activity. Here we show that when lymphoma cells were transformed with a constitutively active form of TMEM16F, they exposed a high level of PS that was comparable to that observed on apoptotic cells. The PS-exposing cells were morphologically normal and grew normally. They efficiently responded to interleukin 3 and underwent apoptosis upon treatment with Fas ligand. The viable PS-exposing cells bound to peritoneal macrophages at 4 °C, but not at 25 °C. Accordingly, these cells were not engulfed by macrophages. When apoptotic cells were injected i.v. into mice, they were phagocytosed by CD11c+CD8+ dendritic cells (DCs) in the spleen, but the PS-exposing living cells were not phagocytosed by these DCs. Furthermore, when PS-exposing lymphoma cells were transplanted s.c. into nude mice, they generated tumors as efficiently as parental lymphoma cells that did not expose PS. These results indicated that PS exposure alone is not sufficient to be recognized by macrophages as an eat-me signal. PMID:22084121

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crane, Cameron C.; Tao, Jing; Wang, Feng

Controlling the deposition of exotic metals in the seeded growth of multi-metal nanostructures is challenging. This work describes a seeded growth method assisted by a mask for synthesis of segmented binary or ternary metal nanostructures. Silica is used as a mask to partially block the surface of a seed and a second metal is subsequently deposited on the exposed area, forming a bimetallic heterodimer. The initial demonstration was carried out on a Au seed, followed by deposition of Pd or Pt on the seed. It was found that Pd tends to spread out laterally on the seed while Pt inclinesmore » to grow vertically into branched topology on Au. Without removal of the SiO₂ mask, Pt could be further deposited on the unblocked Pd of the Pd-Au dimer to form a Pt-Pd-Au trimer. The mask-assisted seeded growth provides a general strategy to construct segmented metallic nanoarchitectures.« less

Flagellin based biomimetic coatings: From cell-repellent surfaces to highly adhesive coatings.

PubMed

Kovacs, Boglarka; Patko, Daniel; Szekacs, Inna; Orgovan, Norbert; Kurunczi, Sandor; Sulyok, Attila; Khanh, Nguyen Quoc; Toth, Balazs; Vonderviszt, Ferenc; Horvath, Robert

2016-09-15

Biomimetic coatings with cell-adhesion-regulating functionalities are intensively researched today. For example, cell-based biosensing for drug development, biomedical implants, and tissue engineering require that the surface adhesion of living cells is well controlled. Recently, we have shown that the bacterial flagellar protein, flagellin, adsorbs through its terminal segments to hydrophobic surfaces, forming an oriented monolayer and exposing its variable D3 domain to the solution. Here, we hypothesized that this nanostructured layer is highly cell-repellent since it mimics the surface of the flagellar filaments. Moreover, we proposed flagellin as a carrier molecule to display the cell-adhesive RGD (Arg-Gly-Asp) peptide sequence and induce cell adhesion on the coated surface. The D3 domain of flagellin was replaced with one or more RGD motifs linked by various oligopeptides modulating flexibility and accessibility of the inserted segment. The obtained flagellin variants were applied to create surface coatings inducing cell adhesion and spreading to different levels, while wild-type flagellin was shown to form a surface layer with strong anti-adhesive properties. As reference surfaces synthetic polymers were applied which have anti-adhesive (PLL-g-PEG poly(l-lysine)-graft-poly(ethylene glycol)) or adhesion inducing properties (RGD-functionalized PLL-g-PEG). Quantitative adhesion data was obtained by employing optical biochips and microscopy. Cell-adhesion-regulating coatings can be simply formed on hydrophobic surfaces by using the developed flagellin-based constructs. The developed novel RGD-displaying flagellin variants can be easily obtained by bacterial production and can serve as alternatives to create cell-adhesion-regulating biomimetic coatings. In the present work, we show for the first time that. Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Posterior subscapular dissection: An improved approach to the brachial plexus for human anatomy students.

PubMed

Hager, Shaun; Backus, Timothy Charles; Futterman, Bennett; Solounias, Nikos; Mihlbachler, Matthew C

2014-05-01

Students of human anatomy are required to understand the brachial plexus, from the proximal roots extending from spinal nerves C5 through T1, to the distal-most branches that innervate the shoulder and upper limb. However, in human cadaver dissection labs, students are often instructed to dissect the brachial plexus using an antero-axillary approach that incompletely exposes the brachial plexus. This approach readily exposes the distal segments of the brachial plexus but exposure of proximal and posterior segments require extensive dissection of neck and shoulder structures. Therefore, the proximal and posterior segments of the brachial plexus, including the roots, trunks, divisions, posterior cord and proximally branching peripheral nerves often remain unobserved during study of the cadaveric shoulder and brachial plexus. Here we introduce a subscapular approach that exposes the entire brachial plexus, with minimal amount of dissection or destruction of surrounding structures. Lateral retraction of the scapula reveals the entire length of the brachial plexus in the subscapular space, exposing the brachial plexus roots and other proximal segments. Combining the subscapular approach with the traditional antero-axillary approach allows students to observe the cadaveric brachial plexus in its entirety. Exposure of the brachial dissection in the subscapular space requires little time and is easily incorporated into a preexisting anatomy lab curriculum without scheduling additional time for dissection. Copyright © 2014 Elsevier GmbH. All rights reserved.

The larval abdomen of the enigmatic Nannochoristidae (Mecoptera, Insecta).

PubMed

Fraulob, Maximilian; Wipfler, Benjamin; Hünefeld, Frank; Pohl, Hans; Beutel, Rolf G

2012-03-01

External and internal structures of the larval abdomen of Nannochorista are described in detail, with emphasis on the posterior segments. The results are compared with conditions found in other groups of Antliophora, especially the mecopteran subgroups Boreidae and Pistillifera. Like the entire postcephalic body, the larval abdomen of Nannochorista is extremely slender and nearly cylindrical. The anterior segments are largely unmodified. The surface is smooth and lacks any protuberances or prolegs. The term "cloaca" for the posterior membranous pouch of Nannochorista sp. is morphologically unjustified. A list of muscles of segments IX and X is presented. The abdominal musculature was partly homologized following Snodgrass. The muscles of segment X are highly modified. They move the membranous pouch, the anal papillae, and the terminal lobes. The presence of these structures is likely an adaptation to the specific aquatic life style of nannochoristid larvae. The anal papillae are possibly homologous to the 4-lobed terminal attachment apparatus of larvae of Caurinus (Boreidae) and Pistillifera (Panorpidae, Bittacidae, Choristidae) but this is uncertain. The specific condition in both groups, i.e. two retractile papillae with tracheae and Malpighian tubules in Nannochoristidae, and a 4-lobed exposed attachment device in Pistillifera + Boreidae (groundplan) are very likely autapomorphic for both groups, respectively. A slender abdomen with smooth surface is very likely plesiomorphic within Antliophora and Mecopterida. This condition is found in Trichoptera (partim), Nannochoristidae, Siphonaptera, and many basal groups of Diptera. An eruciform or scarabaeiform body shape with a soft, largely unsclerotised cuticle is probably a synapomorphy of Boreidae and Pistillifera. The presence of ventral protuberances resembling prolegs on the anterior segments is an autapomorphy of the latter group. The homology of paired or unpaired terminal appendages of segment X is uncertain. However, the specific condition of paired and 3-segmented appendages with hooks in Nannochoristidae is almost certainly autapomorphic for this family. The protracted opening of the hind gut on the membranous pouch is another potential autapomorphy of Nannochoristidae. Aquatic habits of larvae, also very likely an apomorphic condition, have likely evolved several times independently in Antliophora. Copyright © 2011 Elsevier Ltd. All rights reserved.

Consistent cortical reconstruction and multi-atlas brain segmentation.

PubMed

Huo, Yuankai; Plassard, Andrew J; Carass, Aaron; Resnick, Susan M; Pham, Dzung L; Prince, Jerry L; Landman, Bennett A

2016-09-01

Whole brain segmentation and cortical surface reconstruction are two essential techniques for investigating the human brain. Spatial inconsistences, which can hinder further integrated analyses of brain structure, can result due to these two tasks typically being conducted independently of each other. FreeSurfer obtains self-consistent whole brain segmentations and cortical surfaces. It starts with subcortical segmentation, then carries out cortical surface reconstruction, and ends with cortical segmentation and labeling. However, this "segmentation to surface to parcellation" strategy has shown limitations in various cohorts such as older populations with large ventricles. In this work, we propose a novel "multi-atlas segmentation to surface" method called Multi-atlas CRUISE (MaCRUISE), which achieves self-consistent whole brain segmentations and cortical surfaces by combining multi-atlas segmentation with the cortical reconstruction method CRUISE. A modification called MaCRUISE(+) is designed to perform well when white matter lesions are present. Comparing to the benchmarks CRUISE and FreeSurfer, the surface accuracy of MaCRUISE and MaCRUISE(+) is validated using two independent datasets with expertly placed cortical landmarks. A third independent dataset with expertly delineated volumetric labels is employed to compare segmentation performance. Finally, 200MR volumetric images from an older adult sample are used to assess the robustness of MaCRUISE and FreeSurfer. The advantages of MaCRUISE are: (1) MaCRUISE constructs self-consistent voxelwise segmentations and cortical surfaces, while MaCRUISE(+) is robust to white matter pathology. (2) MaCRUISE achieves more accurate whole brain segmentations than independently conducting the multi-atlas segmentation. (3) MaCRUISE is comparable in accuracy to FreeSurfer (when FreeSurfer does not exhibit global failures) while achieving greater robustness across an older adult population. MaCRUISE has been made freely available in open source. Copyright © 2016 Elsevier Inc. All rights reserved.

Russian Extravehicular Activity (EVA) 21A EXPOSE-R

NASA Image and Video Library

2009-03-10

ISS018-E-039227 (10 March 2009) --- One of two Expedition 18 spacewalkers on March 10 provided this close-up image of the Expose-R experiment, reinstalled a short while earlier on the outside of the Russian segment of the International Space Station. The European experiment is equipped with three trays which contain a variety of biological samples.

Russian Extravehicular Activity (EVA) 21A EXPOSE-R

NASA Image and Video Library

2009-03-10

ISS018-E-039228 (10 March 2009) --- One of two Expedition 18 spacewalkers on March 10 provided this close-up image of the Expose-R experiment, reinstalled a short while earlier on the outside of the Russian segment of the International Space Station. The European experiment is equipped with three trays which contain a variety of biological samples.

Russian Extravehicular Activity (EVA) 21A EXPOSE-R

NASA Image and Video Library

2009-03-10

ISS018-E-039226 (10 March 2009) --- One of two Expedition 18 spacewalkers on March 10 provided this close-up image of the Expose-R experiment, reinstalled a short while earlier on the outside of the Russian segment of the International Space Station. The European experiment is equipped with three trays which contain a variety of biological samples.

Automatic intraoperative fiducial-less patient registration using cortical surface

NASA Astrophysics Data System (ADS)

Fan, Xiaoyao; Roberts, David W.; Olson, Jonathan D.; Ji, Songbai; Paulsen, Keith D.

2017-03-01

In image-guided neurosurgery, patient registration is typically performed in the operating room (OR) at the beginning of the procedure to establish the patient-to-image transformation. The accuracy and efficiency of patient registration are crucial as they are associated with surgical outcome, workflow, and healthcare costs. In this paper, we present an automatic fiducial-less patient registration (FLR) by directly registering cortical surface acquired from intraoperative stereovision (iSV) with preoperative MR (pMR) images without incorporating any prior information, and illustrate the method using one patient example. T1-weighted MR images were acquired prior to surgery and the brain was segmented. After dural opening, an image pair of the exposed cortical surface was acquired using an intraoperative stereovision (iSV) system, and a three-dimensional (3D) texture-encoded profile of the cortical surface was reconstructed. The 3D surface was registered with pMR using a multi-start binary registration method to determine the location and orientation of the iSV patch with respect to the segmented brain. A final transformation was calculated to establish the patient-to-MR relationship. The total computational time was 30 min, and can be significantly improved through code optimization, parallel computing, and/or graphical processing unit (GPU) acceleration. The results show that the iSV texture map aligned well with pMR using the FLR transformation, while misalignment was evident with fiducial-based registration (FBR). The difference between FLR and FBR was calculated at the center of craniotomy and the resulting distance was 4.34 mm. The results presented in this paper suggest potential for clinical application in the future.

Exhumation of Basement-cored Uplifts: Example of the Kyrgyz Range Quantified with Apatite Fission-track Thermochronology

NASA Technical Reports Server (NTRS)

Sobel, Edward R.; Oskin, Michael; Burbank, Douglas; Mikolaichuk, Alexander

2005-01-01

The Kyrgyz Range, the northernmost portion of the Kyrgyzstan Tien Shan, displays topographic evidence for lateral propagation of surface uplift and exhumation. The highest and most deeply dissected segment lies in the center of the range. To the east, topography and relief decrease, and preserved remnants of a Cretaceous regional erosion surface imply minimal amounts of bedrock exhumation. The timing of exhumation of range segments defines the lateral propagation rate of the range-bounding reverse fault and quantifies the time and erosion depth needed to transform a mountain range from a juvenile to a mature morphology. New apatite fission-track (AFT) data from three transects from the eastern Kyrgyz Range, combined with published AFT data, demonstrate that the range has propagated over 110 km eastwards over the last 7-11 Myr. Based on the thermal and topographic evolutionary history, we present a model for a time-varying exhumation rate driven by rock uplift and changes in erodability and the time scale of geomorphic adjustment to surface uplift. Easily eroded, Cenozoic sedimentary rocks overlying resistant basement control early, rapid exhumation and slow surface upliftrates. As increasing amounts of resistant basement are exposed, exhumation rates decrease while surface uplift rates are sustained or increase, thereby growing topography. As the range becomes high enough to cause ice accumulation and develop steep river valleys, fluvial and glacial erosion become more powerful and exhumation rates once again increase. Independently determined range-noma1 shortening rates have also varied over time, suggesting a feedback between erosional efficiency and shortening rate.

Depressing effect of electroacupuncture on the spinal non-painful sensory input of the rat.

PubMed

Quiroz-González, Salvador; Segura-Alegría, Bertha; Jiménez-Estrada, Ismael

2014-09-01

The aim of this study was to explore the effect of electroacupuncture (EA) applied in the Zusanli (ST36) and Sanyinjiao (SP6) points on the N1 component of the cord dorsum potential (CDP) evoked by electrical stimulation of the sural nerve (SU) in the rat. The experiments were performed in 44 Wistar rats (250-300 g) anesthetized with ketamine (100 mg/kg) and xylazine (2 mg/kg). A bilateral laminectomy was performed to expose the L3 to S2 segments of the spinal cord. The SU nerve was exposed and placed on pairs of hook electrodes for electrical stimulation. The N1-CDPs were recorded with three silver-ball electrodes located on the dorsal surface of the L5 to S1 segments. Ipsilateral high and low EA stimulation (100, 2 Hz, 6 mA, 30 min) induced a considerable reduction in the amplitude (45 ± 5.6, 41 ± 6.2%) of the N1-CDP recorded at the L6 segmental level. Recovery of the N1-CDP amplitude occurred approximately 1-3 s after EA. Sectioning of the saphenous and superficial peroneal nerves reduced the depressing effect provoked by the EA stimulation (18.7 ± 1.3, 27 ± 3.8%). Similarly, sectioning of the posterior and anterior tibial, deep peroneal and gastrocnemius nerves partially reduced the effect provoked by EA (11 ± 1.5, 9.8 ± 1.1, 12.6 ± 1.9%). Intravenous picrotoxin (1 mg/kg) also reduced the action of low and high EA (23 ± 4.8, 27 ± 5.2%). It is suggested that EA stimulation depresses non-painful sensory pathways through the activation of specific inhibitory pathways that receive modulatory actions from other sensory and muscle afferent inputs in the rat spinal cord.

Wedge edge ceramic combustor tile

DOEpatents

Shaffer, J.E.; Holsapple, A.C.

1997-06-10

A multipiece combustor has a portion thereof being made of a plurality of ceramic segments. Each of the plurality of ceramic segments have an outer surface and an inner surface. Each of the plurality of ceramic segments have a generally cylindrical configuration and including a plurality of joints. The joints define joint portions, a first portion defining a surface being skewed to the outer surface and the inner surface. The joint portions have a second portion defining a surface being skewed to the outer surface and the inner surface. The joint portions further include a shoulder formed intermediate the first portion and the second portion. The joints provide a sealing interlocking joint between corresponding ones of the plurality of ceramic segments. Thus, the multipiece combustor having the plurality of ceramic segment with the plurality of joints reduces the physical size of the individual components and the degradation of the surface of the ceramic components in a tensile stress zone is generally eliminated reducing the possibility of catastrophic failures. 7 figs.

Wedge edge ceramic combustor tile

DOEpatents

Shaffer, James E.; Holsapple, Allan C.

1997-01-01

A multipiece combustor has a portion thereof being made of a plurality of ceramic segments. Each of the plurality of ceramic segments have an outer surface and an inner surface. Each of the plurality of ceramic segments have a generally cylindrical configuration and including a plurality of joints. The joints define joint portions, a first portion defining a surface being skewed to the outer surface and the inner surface. The joint portions have a second portion defining a surface being skewed to the outer surface and the inner surface. The joint portions further include a shoulder formed intermediate the first portion and the second portion. The joints provide a sealing interlocking joint between corresponding ones of the plurality of ceramic segments. Thus, the multipiece combustor having the plurality of ceramic segment with the plurality of joints reduces the physical size of the individual components and the degradation of the surface of the ceramic components in a tensile stress zone is generally eliminated reducing the possibility of catastrophic failures.

Comparison and assessment of semi-automatic image segmentation in computed tomography scans for image-guided kidney surgery.

PubMed

Glisson, Courtenay L; Altamar, Hernan O; Herrell, S Duke; Clark, Peter; Galloway, Robert L

2011-11-01

Image segmentation is integral to implementing intraoperative guidance for kidney tumor resection. Results seen in computed tomography (CT) data are affected by target organ physiology as well as by the segmentation algorithm used. This work studies variables involved in using level set methods found in the Insight Toolkit to segment kidneys from CT scans and applies the results to an image guidance setting. A composite algorithm drawing on the strengths of multiple level set approaches was built using the Insight Toolkit. This algorithm requires image contrast state and seed points to be identified as input, and functions independently thereafter, selecting and altering method and variable choice as needed. Semi-automatic results were compared to expert hand segmentation results directly and by the use of the resultant surfaces for registration of intraoperative data. Direct comparison using the Dice metric showed average agreement of 0.93 between semi-automatic and hand segmentation results. Use of the segmented surfaces in closest point registration of intraoperative laser range scan data yielded average closest point distances of approximately 1 mm. Application of both inverse registration transforms from the previous step to all hand segmented image space points revealed that the distance variability introduced by registering to the semi-automatically segmented surface versus the hand segmented surface was typically less than 3 mm both near the tumor target and at distal points, including subsurface points. Use of the algorithm shortened user interaction time and provided results which were comparable to the gold standard of hand segmentation. Further, the use of the algorithm's resultant surfaces in image registration provided comparable transformations to surfaces produced by hand segmentation. These data support the applicability and utility of such an algorithm as part of an image guidance workflow.

Social interaction facilitates word learning in preverbal infants: Word-object mapping and word segmentation.

PubMed

Hakuno, Yoko; Omori, Takahide; Yamamoto, Jun-Ichi; Minagawa, Yasuyo

2017-08-01

In natural settings, infants learn spoken language with the aid of a caregiver who explicitly provides social signals. Although previous studies have demonstrated that young infants are sensitive to these signals that facilitate language development, the impact of real-life interactions on early word segmentation and word-object mapping remains elusive. We tested whether infants aged 5-6 months and 9-10 months could segment a word from continuous speech and acquire a word-object relation in an ecologically valid setting. In Experiment 1, infants were exposed to a live tutor, while in Experiment 2, another group of infants were exposed to a televised tutor. Results indicate that both younger and older infants were capable of segmenting a word and learning a word-object association only when the stimuli were derived from a live tutor in a natural manner, suggesting that real-life interaction enhances the learning of spoken words in preverbal infants. Copyright © 2017 Elsevier Inc. All rights reserved.

Physical basis for river segmentation from water surface observables

NASA Astrophysics Data System (ADS)

Samine Montazem, A.; Garambois, P. A.; Calmant, S.; Moreira, D. M.; Monnier, J.; Biancamaria, S.

2017-12-01

With the advent of satellite missions such as SWOT we will have access to high resolution estimates of the elevation, slope and width of the free surface. A segmentation strategy is required in order to sub-sample the data set into reach master points for further hydraulic analyzes and inverse modelling. The question that arises is : what will be the best node repartition strategy that preserves hydraulic properties of river flow? The concept of hydraulic visibility introduced by Garambois et al. (2016) is investigated in order to highlight and characterize the spatio-temporal variations of water surface slope and curvature for different flow regimes and reach geometries. We show that free surface curvature is a powerful proxy for characterizing the hydraulic behavior of a reach since concavity of water surface is driven by variations in channel geometry that impacts the hydraulic properties of the flow. We evaluated the performance of three segmentation strategies by means of a well documented case, that of the Garonne river in France. We conclude that local extrema of free surface curvature appear as the best candidate for locating the segment boundaries for an optimal hydraulic representation of the segmented river. We show that for a given river different segmentation scales are possible: a fine-scale segmentation which is driven by fine-scale hydraulic to large-scale segmentation driven by large-scale geomorphology. The segmentation technique is then applied to high resolution GPS profiles of free surface elevation collected on the Negro river basin, a major contributor of the Amazon river. We propose two segmentations: a low-resolution one that can be used for basin hydrology and a higher resolution one better suited for local hydrodynamic studies.

[Bacterial biofilms on PVC tubing's inner surface of hemodialysis water treatment system].

PubMed

Yang, Sha; Jia, Ke; Peng, Youming; Liu, Hong; Liu, Yinghong; Chen, Xing; Liu, Fuyou

2009-10-01

To determine the morphology, bacteria and endotoxin content of biofilms on the inner surface of PVC tubes in hemodialysis water treatment system. We dissolved biofilms of segments before and after reverse osmosis machine for bacterial count and identification. We studied biofilm structure of segments before and after reverse osmosis machine with eyes and scanning electron microscope. Biofilms of all 7 segments were dissolved for qualitative and quantitative assay of endotoxin. The inner surface of segment before reverse osmosis machine was homogeneously distributed with activated carbon powder deposition. The segment after reverse osmosis machine was normal. With scanning electron microscope, biofilm with successive surface and sandwich was found on the inner surface of segment before reverse osmosis machine, formed by clustering bacillus, activated carbon powder and some coccus. Bacteria of the same shape and length were found on segment after reverse osmosis machine, but fewer and looser. Bacterial culture and identification showed the former was mostly gram-negative bacillus, the latter was only a few micrococcus. Endotoxin of biofilm was between 2.0 EU/mL and 4.0 EU/mL. Quantitative assay showed: segment after softener (2.821+/-0.807) EU/mL; segment after active charcoal canister(3.635+/-0.427) EU/mL; segment before reverse osmosis machine (3.687+/-0.271) EU/mL; segment after reverse osmosis machine (2.041+/-0.295) EU/mL; exit of power pump (1.983+/-0.390)EU/mL;the 1st dead space (2.373+/-0.535) EU/mL; and the 2nd dead space (2.858+/-0.690)EU/mL. Biofilms are found on the inner surface of segment before and after reverse osmosis machine. Endotoxin level from high to low is as follows: segment before reverse osmosis machine, segment after active charcoal canister, the 2nd dead space, segment after softener, the 1st dead space, segment after reverse osmosis machine, exit of power pump. The character of the bacteria and endotoxin of the biofilm can help us find better ways to control them.

Automated 3D closed surface segmentation: application to vertebral body segmentation in CT images.

PubMed

Liu, Shuang; Xie, Yiting; Reeves, Anthony P

2016-05-01

A fully automated segmentation algorithm, progressive surface resolution (PSR), is presented in this paper to determine the closed surface of approximately convex blob-like structures that are common in biomedical imaging. The PSR algorithm was applied to the cortical surface segmentation of 460 vertebral bodies on 46 low-dose chest CT images, which can be potentially used for automated bone mineral density measurement and compression fracture detection. The target surface is realized by a closed triangular mesh, which thereby guarantees the enclosure. The surface vertices of the triangular mesh representation are constrained along radial trajectories that are uniformly distributed in 3D angle space. The segmentation is accomplished by determining for each radial trajectory the location of its intersection with the target surface. The surface is first initialized based on an input high confidence boundary image and then resolved progressively based on a dynamic attraction map in an order of decreasing degree of evidence regarding the target surface location. For the visual evaluation, the algorithm achieved acceptable segmentation for 99.35 % vertebral bodies. Quantitative evaluation was performed on 46 vertebral bodies and achieved overall mean Dice coefficient of 0.939 (with max [Formula: see text] 0.957, min [Formula: see text] 0.906 and standard deviation [Formula: see text] 0.011) using manual annotations as the ground truth. Both visual and quantitative evaluations demonstrate encouraging performance of the PSR algorithm. This novel surface resolution strategy provides uniform angular resolution for the segmented surface with computation complexity and runtime that are linearly constrained by the total number of vertices of the triangular mesh representation.

Fault zone processes in mechanically layered mudrock and chalk

NASA Astrophysics Data System (ADS)

Ferrill, David A.; Evans, Mark A.; McGinnis, Ronald N.; Morris, Alan P.; Smart, Kevin J.; Wigginton, Sarah S.; Gulliver, Kirk D. H.; Lehrmann, Daniel; de Zoeten, Erich; Sickmann, Zach

2017-04-01

A 1.5 km long natural cliff outcrop of nearly horizontal Eagle Ford Formation in south Texas exposes northwest and southeast dipping normal faults with displacements of 0.01-7 m cutting mudrock, chalk, limestone, and volcanic ash. These faults provide analogs for both natural and hydraulically-induced deformation in the productive Eagle Ford Formation - a major unconventional oil and gas reservoir in south Texas, U.S.A. - and other mechanically layered hydrocarbon reservoirs. Fault dips are steep to vertical through chalk and limestone beds, and moderate through mudrock and clay-rich ash, resulting in refracted fault profiles. Steeply dipping fault segments contain rhombohedral calcite veins that cross the fault zone obliquely, parallel to shear segments in mudrock. The vertical dimensions of the calcite veins correspond to the thickness of offset competent beds with which they are contiguous, and the slip parallel dimension is proportional to fault displacement. Failure surface characteristics, including mixed tensile and shear segments, indicate hybrid failure in chalk and limestone, whereas shear failure predominates in mudrock and ash beds - these changes in failure mode contribute to variation in fault dip. Slip on the shear segments caused dilation of the steeper hybrid segments. Tabular sheets of calcite grew by repeated fault slip, dilation, and cementation. Fluid inclusion and stable isotope geochemistry analyses of fault zone cements indicate episodic reactivation at 1.4-4.2 km depths. The results of these analyses document a dramatic bed-scale lithologic control on fault zone architecture that is directly relevant to the development of porosity and permeability anisotropy along faults.

Peano-like paths for subaperture polishing of optical aspherical surfaces.

PubMed

Tam, Hon-Yuen; Cheng, Haobo; Dong, Zhichao

2013-05-20

Polishing can be more uniform if the polishing path provides uniform coverage of the surface. It is known that Peano paths can provide uniform coverage of planar surfaces. Peano paths also contain short path segments and turns: (1) all path segments have the same length, (2) path segments are mutually orthogonal at the turns, and (3) path segments and turns are uniformity distributed over the domain surface. These make Peano paths an attractive candidate among polishing tool paths because they enhance multidirectional approaches of the tool to each surface location. A method for constructing Peano paths for uniform coverage of aspherical surfaces is proposed in this paper. When mapped to the aspherical surface, the path also contains short path segments and turns, and the above attributes are approximately preserved. Attention is paid so that the path segments are still well distributed near the vertex of the surface. The proposed tool path was used in the polishing of a number of parabolic BK7 specimens using magnetorheological finishing (MRF) and pitch with cerium oxide. The results were rather good for optical lenses and confirm that a Peano-like path was useful for polishing, for MRF, and for pitch polishing. In the latter case, the surface roughness achieved was 0.91 nm according to WYKO measurement.

Proximal lava drainage controls on basaltic fissure eruption dynamics

NASA Astrophysics Data System (ADS)

Jones, T. J.; Llewellin, E. W.; Houghton, B. F.; Brown, R. J.; Vye-Brown, C.

2017-11-01

Hawaiian basaltic eruptions commonly initiate as a fissure, producing fountains, spattering, and clastogenic lava flows. Most fissures rapidly localize to form a small number of eruptive vents, the location of which may influence the subsequent distribution of lava flows and associated hazards. We present results from a detailed field investigation of the proximal deposits of episode 1 of the 1969 fissure eruption of Mauna Ulu, Kīlauea, Hawai`i. Exceptional preservation of the deposits allows us to reconstruct vent-proximal lava drainage patterns and to assess the role that drainage played in constraining vent localization. Through detailed field mapping, including measurements of the height and internal depth of lava tree moulds, we reconstruct high-resolution topographic maps of the pre-eruption ground surface, the lava high-stand surface and the post-eruption ground surface. We calculate the difference in elevation between pairs of maps to estimate the lava inundation depth and lava drainage depth over the field area and along different segments of fissure. Aerial photographs collected during episode 1 of the eruption allow us to locate those parts of the fissure that are no longer exposed at the surface. By comparing with the inundation and drainage maps, we find that fissure segments that were inundated with lava to greater depths (typically 1-6 m) during the eruption later became foci of lava drainage back into the fissure (internal drain-back). We infer that, in these areas, lava ponding over the fissure suppressed discharge of magma, thereby favouring drain-back and stagnation. By contrast, segments with relatively shallow inundation (typically less than 1 m), such as where the fissure intersects pre-eruptive topographic highs, or where flow away from the vent (outflow) was efficient, are often associated with sub-circular vent geometries in the post-eruption ground surface. We infer that these parts of the fissure became localization points for ongoing magma ascent and discharge. We conclude that lava inundation and drainage processes in basaltic fissure eruptions can play an important role in controlling their localization and longevity.

Multi-Scale Voxel Segmentation for Terrestrial Lidar Data within Marshes

NASA Astrophysics Data System (ADS)

Nguyen, C. T.; Starek, M. J.; Tissot, P.; Gibeaut, J. C.

2016-12-01

The resilience of marshes to a rising sea is dependent on their elevation response. Terrestrial laser scanning (TLS) is a detailed topographic approach for accurate, dense surface measurement with high potential for monitoring of marsh surface elevation response. The dense point cloud provides a 3D representation of the surface, which includes both terrain and non-terrain objects. Extraction of topographic information requires filtering of the data into like-groups or classes, therefore, methods must be incorporated to identify structure in the data prior to creation of an end product. A voxel representation of three-dimensional space provides quantitative visualization and analysis for pattern recognition. The objectives of this study are threefold: 1) apply a multi-scale voxel approach to effectively extract geometric features from the TLS point cloud data, 2) investigate the utility of K-means and Self Organizing Map (SOM) clustering algorithms for segmentation, and 3) utilize a variety of validity indices to measure the quality of the result. TLS data were collected at a marsh site along the central Texas Gulf Coast using a Riegl VZ 400 TLS. The site consists of both exposed and vegetated surface regions. To characterize structure of the point cloud, octree segmentation is applied to create a tree data structure of voxels containing the points. The flexibility of voxels in size and point density makes this algorithm a promising candidate to locally extract statistical and geometric features of the terrain including surface normal and curvature. The characteristics of the voxel itself such as the volume and point density are also computed and assigned to each point as are laser pulse characteristics. The features extracted from the voxelization are then used as input for clustering of the points using the K-means and SOM clustering algorithms. Optimal number of clusters are then determined based on evaluation of cluster separability criterions. Results for different combinations of the feature space vector and differences between K-means and SOM clustering will be presented. The developed method provides a novel approach for compressing TLS scene complexity in marshes, such as for vegetation biomass studies or erosion monitoring.

Dynamic bioactive stimuli-responsive polymeric surfaces

NASA Astrophysics Data System (ADS)

Pearson, Heather Marie

This dissertation focuses on the design, synthesis, and development of antimicrobial and anticoagulant surfaces of polyethylene (PE), polypropylene (PP), and poly(tetrafluoroethylene) (PTFE) polymers. Aliphatic polymeric surfaces of PE and PP polymers functionalized using click chemistry reactions by the attachment of --COOH groups via microwave plasma reactions followed by functionalization with alkyne moieties. Azide containing ampicillin (AMP) was synthesized and subsequently clicked into the alkyne prepared PE and PP surfaces. Compared to non-functionalized PP and PE surfaces, the AMP clicked surfaces exhibited substantially enhanced antimicrobial activity against Staphylococcus aureus bacteria. To expand the biocompatibility of polymeric surface anticoagulant attributes, PE and PTFE surfaces were functionalized with pH-responsive poly(2-vinyl pyridine) (P2VP) and poly(acrylic acid) (PAA) polyelectrolyte tethers terminated with NH2 and COOH groups. The goal of these studies was to develop switchable stimuli-responsive polymeric surfaces that interact with biological environments and display simultaneous antimicrobial and anticoagulant properties. Antimicrobial AMP was covalently attached to --COOH terminal ends of protected PAA, while anticoagulant heparin (HEP) was attached to terminal --NH2 groups of P2VP. When pH < 2.3, the P2VP segments are protonated and extend, but for pH > 5.5, they collapse while the PAA segments extend. Such surfaces, when exposed to Staphylococcus aureus, inhibit bacterial growth due to the presence of AMP, as well as are effective anticoagulants due to the presence of covalently attached HEP. Comparison of these "dynamic" pH responsive surfaces with "static" surfaces terminated with AMP entities show significant enhancement of longevity and surface activity against microbial film formation. The last portion of this dissertation focuses on the covalent attachment of living T1 and Φ11 bacteriophages (phages) on PE and PTFE surface. This was accomplished by carbodiimide coupling between --COOH groups on PE and PTFE surfaces and --NH2 moieties present on T1 and Φ11 phages. These studies show that covalently attached T1 and Φ11 phages retain their antimicrobial activity manifested by the effective destruction of both Gram negative Escherichia coli (Φ11) phages and Gram positive Staphylococcus aureus bacteria (T1).

Application of ground-penetrating radar to investigation of near-surface fault properties in the San Francisco Bay region

USGS Publications Warehouse

Cai, J.; McMechan, G.A.; Fisher, M.A.

1996-01-01

In many geologic environments, ground-penetrating radar (GPR) provides high-resolution images of near-surface Earth structure. GPR data collection is nondestructive and very economical. The scale of features detected by GPR lies between those imaged by high-resolution seismic reflection surveys and those exposed in trenches and is therefore potentially complementary to traditional techniques for fault location and mapping. Sixty-two GPR profiles were collected at 12 sites in the San Francisco Bay region. Results show that GPR data correlate with large-scale features in existing trench observations, can be used to locate faults where they are buried or where their positions are not well known, and can identify previously unknown fault segments. The best data acquired were on a profile across the San Andreas fault, traversing Pleistocene terrace deposits south of Olema in Marin County; this profile shows a complicated multi-branched fault system from the ground surface down to about 40 m, the maximum depth for which data were recorded.

Brain segmentation and the generation of cortical surfaces

NASA Technical Reports Server (NTRS)

Joshi, M.; Cui, J.; Doolittle, K.; Joshi, S.; Van Essen, D.; Wang, L.; Miller, M. I.

1999-01-01

This paper describes methods for white matter segmentation in brain images and the generation of cortical surfaces from the segmentations. We have developed a system that allows a user to start with a brain volume, obtained by modalities such as MRI or cryosection, and constructs a complete digital representation of the cortical surface. The methodology consists of three basic components: local parametric modeling and Bayesian segmentation; surface generation and local quadratic coordinate fitting; and surface editing. Segmentations are computed by parametrically fitting known density functions to the histogram of the image using the expectation maximization algorithm [DLR77]. The parametric fits are obtained locally rather than globally over the whole volume to overcome local variations in gray levels. To represent the boundary of the gray and white matter we use triangulated meshes generated using isosurface generation algorithms [GH95]. A complete system of local parametric quadratic charts [JWM+95] is superimposed on the triangulated graph to facilitate smoothing and geodesic curve tracking. Algorithms for surface editing include extraction of the largest closed surface. Results for several macaque brains are presented comparing automated and hand surface generation. Copyright 1999 Academic Press.

Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate.

PubMed

Hua, Qing-xin; Weiss, Michael A

2004-05-14

Insulin undergoes aggregation-coupled misfolding to form a cross-beta assembly. Such fibrillation has long complicated its manufacture and use in the therapy of diabetes mellitus. Of interest as a model for disease-associated amyloids, insulin fibrillation is proposed to occur via partial unfolding of a monomeric intermediate. Here, we describe the solution structure of human insulin under amyloidogenic conditions (pH 2.4 and 60 degrees C). Use of an enhanced sensitivity cryogenic probe at high magnetic field avoids onset of fibrillation during spectral acquisition. A novel partial fold is observed in which the N-terminal segments of the A- and B-chains detach from the core. Unfolding of the N-terminal alpha-helix of the A-chain exposes a hydrophobic surface formed by native-like packing of the remaining alpha-helices. The C-terminal segment of the B-chain, although not well ordered, remains tethered to this partial helical core. We propose that detachment of N-terminal segments makes possible aberrant protein-protein interactions in an amyloidogenic nucleus. Non-cooperative unfolding of the N-terminal A-chain alpha-helix resembles that observed in models of proinsulin folding intermediates and foreshadows the extensive alpha --> beta transition characteristic of mature fibrils.

Lung Segmentation Refinement based on Optimal Surface Finding Utilizing a Hybrid Desktop/Virtual Reality User Interface

PubMed Central

Sun, Shanhui; Sonka, Milan; Beichel, Reinhard R.

2013-01-01

Recently, the optimal surface finding (OSF) and layered optimal graph image segmentation of multiple objects and surfaces (LOGISMOS) approaches have been reported with applications to medical image segmentation tasks. While providing high levels of performance, these approaches may locally fail in the presence of pathology or other local challenges. Due to the image data variability, finding a suitable cost function that would be applicable to all image locations may not be feasible. This paper presents a new interactive refinement approach for correcting local segmentation errors in the automated OSF-based segmentation. A hybrid desktop/virtual reality user interface was developed for efficient interaction with the segmentations utilizing state-of-the-art stereoscopic visualization technology and advanced interaction techniques. The user interface allows a natural and interactive manipulation on 3-D surfaces. The approach was evaluated on 30 test cases from 18 CT lung datasets, which showed local segmentation errors after employing an automated OSF-based lung segmentation. The performed experiments exhibited significant increase in performance in terms of mean absolute surface distance errors (2.54 ± 0.75 mm prior to refinement vs. 1.11 ± 0.43 mm post-refinement, p ≪ 0.001). Speed of the interactions is one of the most important aspects leading to the acceptance or rejection of the approach by users expecting real-time interaction experience. The average algorithm computing time per refinement iteration was 150 ms, and the average total user interaction time required for reaching complete operator satisfaction per case was about 2 min. This time was mostly spent on human-controlled manipulation of the object to identify whether additional refinement was necessary and to approve the final segmentation result. The reported principle is generally applicable to segmentation problems beyond lung segmentation in CT scans as long as the underlying segmentation utilizes the OSF framework. The two reported segmentation refinement tools were optimized for lung segmentation and might need some adaptation for other application domains. PMID:23415254

Electric field theory based approach to search-direction line definition in image segmentation: application to optimal femur-tibia cartilage segmentation in knee-joint 3-D MR

NASA Astrophysics Data System (ADS)

Yin, Y.; Sonka, M.

2010-03-01

A novel method is presented for definition of search lines in a variety of surface segmentation approaches. The method is inspired by properties of electric field direction lines and is applicable to general-purpose n-D shapebased image segmentation tasks. Its utility is demonstrated in graph construction and optimal segmentation of multiple mutually interacting objects. The properties of the electric field-based graph construction guarantee that inter-object graph connecting lines are non-intersecting and inherently covering the entire object-interaction space. When applied to inter-object cross-surface mapping, our approach generates one-to-one and all-to-all vertex correspondent pairs between the regions of mutual interaction. We demonstrate the benefits of the electric field approach in several examples ranging from relatively simple single-surface segmentation to complex multiobject multi-surface segmentation of femur-tibia cartilage. The performance of our approach is demonstrated in 60 MR images from the Osteoarthritis Initiative (OAI), in which our approach achieved a very good performance as judged by surface positioning errors (average of 0.29 and 0.59 mm for signed and unsigned cartilage positioning errors, respectively).

Serially connected solid oxide fuel cells having monolithic cores

DOEpatents

Herceg, Joseph E.

1987-01-01

A solid oxide fuel cell for electrochemically combining fuel and oxidant for generating galvanic output, wherein the cell core has an array of cell segments electrically serially connected in the flow direction, each segment consisting of electrolyte walls and interconnect that are substantially devoid of any composite inert materials for support. Instead, the core is monolithic, where each electrolyte wall consists of thin layers of cathode and anode materials sandwiching a thin layer of electrolyte material therebetween. Means direct the fuel to the anode-exposed core passageways and means direct the oxidant to the cathode-exposed core passageways; and means also direct the galvanic output to an exterior circuit. Each layer of the electrolyte composite materials is of the order of 0.002-0.01 cm thick; and each layer of the cathode and anode materials is of the order of 0.002-0.05 cm thick. Between 2 and 50 cell segments may be connected in series.

Degradation of orthodontic wires under simulated cariogenic and erosive conditions.

PubMed

Jaber, Laura Cavalcante Lima; Rodrigues, José Augusto; Amaral, Flávia Lucisano Botelho; França, Fabiana Mantovani Gomes; Basting, Roberta Tarkany; Turssi, Cecilia Pedroso

2014-01-01

This study examined the effect of cariogenic and erosive challenges (CCs and ECs, respectively) on the degradation of copper-nickel-titanium (CuNiTi) orthodontic wires. Sixty wire segments were divided into four treatment groups and exposed to CCs, ECs, artificial saliva, or dry storage (no-treatment control). CC and EC were simulated using a demineralizing solution (pH 4.3) and a citric acid solution (pH 2.3), respectively. Following treatment, the average surface roughness (Ra) of the wires was assessed, and friction between the wires and a passive self-ligating bracket was measured. CuNiTi wires subjected to ECs exhibited significantly higher Ra values than did those that were stored in artificial saliva. In contrast, surface roughness was not affected by CCs. Finally, friction between the treated wires and brackets was not affected by ECs or CCs. Our results indicate that CuNiTi orthodontic wires may suffer degradation within the oral cavity, as ECs increased the surface roughness of these wires. However, rougher surfaces did not increase friction between the wire and the passive self-ligating bracket.

Micro-fabricated integrated coil and magnetic circuit and method of manufacturing thereof

DOEpatents

Mihailovich, Robert E.; Papavasiliou, Alex P.; Mehrotra, Vivek; Stupar, Philip A.; Borwick, III, Robert L.; Ganguli, Rahul; DeNatale, Jeffrey F.

2017-03-28

A micro-fabricated electromagnetic device is provided for on-circuit integration. The electromagnetic device includes a core. The core has a plurality of electrically insulating layers positioned alternatingly between a plurality of magnetic layers to collectively form a continuous laminate having alternating magnetic and electrically insulating layers. The electromagnetic device includes a coil embedded in openings of the semiconductor substrate. An insulating material is positioned in the cavity and between the coil and an inner surface of the core. A method of manufacturing the electromagnetic device includes providing a semiconductor substrate having openings formed therein. Windings of a coil are electroplated and embedded in the openings. The insulating material is coated on or around an exposed surface of the coil. Alternating magnetic layers and electrically insulating layers may be micro-fabricated and electroplated as a single and substantially continuous segment on or around the insulating material.

Automated segmentation of the prostate in 3D MR images using a probabilistic atlas and a spatially constrained deformable model.

PubMed

Martin, Sébastien; Troccaz, Jocelyne; Daanenc, Vincent

2010-04-01

The authors present a fully automatic algorithm for the segmentation of the prostate in three-dimensional magnetic resonance (MR) images. The approach requires the use of an anatomical atlas which is built by computing transformation fields mapping a set of manually segmented images to a common reference. These transformation fields are then applied to the manually segmented structures of the training set in order to get a probabilistic map on the atlas. The segmentation is then realized through a two stage procedure. In the first stage, the processed image is registered to the probabilistic atlas. Subsequently, a probabilistic segmentation is obtained by mapping the probabilistic map of the atlas to the patient's anatomy. In the second stage, a deformable surface evolves toward the prostate boundaries by merging information coming from the probabilistic segmentation, an image feature model and a statistical shape model. During the evolution of the surface, the probabilistic segmentation allows the introduction of a spatial constraint that prevents the deformable surface from leaking in an unlikely configuration. The proposed method is evaluated on 36 exams that were manually segmented by a single expert. A median Dice similarity coefficient of 0.86 and an average surface error of 2.41 mm are achieved. By merging prior knowledge, the presented method achieves a robust and completely automatic segmentation of the prostate in MR images. Results show that the use of a spatial constraint is useful to increase the robustness of the deformable model comparatively to a deformable surface that is only driven by an image appearance model.

Aromaticity at the water-hydrocarbon core interface of the membrane

PubMed Central

Lizardi-Ortiz, José E.; Hyzinski-García, María C.; Fernández-Gerena, José L.; Osorio-Martínez, Karen M.; Velázquez-Rivera, Eric; Valle-Avilés, Félix L.; Lasalde-Dominicci, José A.

2011-01-01

Almost all lipid-exposed transmembrane domains of integral proteins contain aromatic residues flanking the hydrophobic segment of the domains. These residues generally reside close to the carbonyl region of the membrane, and several structural and functional roles have been associated to these residues. Although the roles and physicochemical reasons for aromatic preference have been extensively studied using model systems, few studies have been done in a native membrane system. To gain insight about the mechanistic implication for this aromatic preference, we selected position αF426 of the muscle-type nicotinic acetylcholine receptor (nAChR). αF426 is a lipid-exposed residue at the extracellular segment of the αM4 transmembrane domain and is highly conserved among different nAChR subunits and species. We used site-directed mutagenesis, α-Bungarotoxin-binding assay, and two-electrodes voltage clamp in Xenopus laevis oocytes to characterize mutations at position αF426, which impart different physicochemical properties like volume, polarity, hydrogen bonds, aromaticity and net electrical charge. All mutations except the aromatic residues resulted in a significant reduction of the nAChR cell-surface levels and the macroscopic currents to acetylcholine. These results suggest that position αF426 contributes to structural stability and open-close transitions of the nAChR. Finally, the present study also provides information about how intermolecular interactions at position α426 modulate open-close transitions of the nAChR. PMID:18836298

Segmentation of 3D ultrasound computer tomography reflection images using edge detection and surface fitting

NASA Astrophysics Data System (ADS)

Hopp, T.; Zapf, M.; Ruiter, N. V.

2014-03-01

An essential processing step for comparison of Ultrasound Computer Tomography images to other modalities, as well as for the use in further image processing, is to segment the breast from the background. In this work we present a (semi-) automated 3D segmentation method which is based on the detection of the breast boundary in coronal slice images and a subsequent surface fitting. The method was evaluated using a software phantom and in-vivo data. The fully automatically processed phantom results showed that a segmentation of approx. 10% of the slices of a dataset is sufficient to recover the overall breast shape. Application to 16 in-vivo datasets was performed successfully using semi-automated processing, i.e. using a graphical user interface for manual corrections of the automated breast boundary detection. The processing time for the segmentation of an in-vivo dataset could be significantly reduced by a factor of four compared to a fully manual segmentation. Comparison to manually segmented images identified a smoother surface for the semi-automated segmentation with an average of 11% of differing voxels and an average surface deviation of 2mm. Limitations of the edge detection may be overcome by future updates of the KIT USCT system, allowing a fully-automated usage of our segmentation approach.

Analysis of carotid lumen surface morphology using three-dimensional ultrasound imaging

NASA Astrophysics Data System (ADS)

Chiu, Bernard; Beletsky, Vadim; Spence, J. David; Parraga, Grace; Fenster, Aaron

2009-03-01

Carotid plaque surface irregularity and ulcerations play an important role in the risk of ischemic stroke. Ulcerated or fissured plaque, characterized by irregular surface morphology, exposes thrombogenic materials to the bloodstream, possibly leading to life- or brain-threatening thrombosis and embolization. Therefore, the quantification of plaque surface irregularity is important to identify high-risk plaques that would likely lead to vascular events. Although a number of studies have characterized plaque surface irregularity using subjective classification schemes with two or more categories, only a few have quantified surface irregularity using an objective and continuous quantity, such as Gaussian or mean curvature. In this work, our goal was to use both Gaussian and mean curvatures for identifying ulcers from 3D carotid ultrasound (US) images of human subjects. Before performing experiments using patient data, we verified the numerical accuracy of the surface curvature computation method using discrete spheres and tori with different sampling intervals. We also showed that three ulcers of the vascular phantom with 2 mm, 3 mm and 4 mm diameters were associated with high Gaussian and mean curvatures, and thus, were easily detected. Finally, we demonstrated the application of the proposed method for detecting ulcers on luminal surfaces, which were segmented from the 3D US images acquired for two human subjects.

Cardiac Multi-detector CT Segmentation Based on Multiscale Directional Edge Detector and 3D Level Set.

PubMed

Antunes, Sofia; Esposito, Antonio; Palmisano, Anna; Colantoni, Caterina; Cerutti, Sergio; Rizzo, Giovanna

2016-05-01

Extraction of the cardiac surfaces of interest from multi-detector computed tomographic (MDCT) data is a pre-requisite step for cardiac analysis, as well as for image guidance procedures. Most of the existing methods need manual corrections, which is time-consuming. We present a fully automatic segmentation technique for the extraction of the right ventricle, left ventricular endocardium and epicardium from MDCT images. The method consists in a 3D level set surface evolution approach coupled to a new stopping function based on a multiscale directional second derivative Gaussian filter, which is able to stop propagation precisely on the real boundary of the structures of interest. We validated the segmentation method on 18 MDCT volumes from healthy and pathologic subjects using manual segmentation performed by a team of expert radiologists as gold standard. Segmentation errors were assessed for each structure resulting in a surface-to-surface mean error below 0.5 mm and a percentage of surface distance with errors less than 1 mm above 80%. Moreover, in comparison to other segmentation approaches, already proposed in previous work, our method presented an improved accuracy (with surface distance errors less than 1 mm increased of 8-20% for all structures). The obtained results suggest that our approach is accurate and effective for the segmentation of ventricular cavities and myocardium from MDCT images.

[Superimposed lichen planus pigmentosus].

PubMed

Monteagudo, Benigno; Suarez-Amor, Óscar; Cabanillas, Miguel; de Las Heras, Cristina; Álvarez, Juan Carlos

2014-05-16

Lichen planus pigmentosus is an uncommon variant of lichen planus that is characterized by the insidious onset of dark brown macules in sun-exposed areas and flexural folds. Superimposed linear lichen planus is an exceedingly rare disorder, but it has been found in both lichen planopilaris and lichen planus types. A 39-year-old woman is presented showing a segmental and linear lichen planus associated with non-segmental lesions meeting all criteria for the diagnosis of superimposed linear planus pigmentosus. The segmental lesions were always more pronounced.

Linking Language and Culture in the Language and Cultural Program of the Lauder Institute: The French Perspective.

ERIC Educational Resources Information Center

Lahaeye, Marie-Noelle

The University of Pennsylvania's Lauder Institute of Management and International Studies introduced a cultural segment into its second language program in 1986 to enable students to use language purposefully within the foreign culture. During the program's 2 years, students are exposed to eight different cultural segments taught by language…

Mechanical and chemical effects of ion-texturing biomedical polymers

NASA Technical Reports Server (NTRS)

Weigand, A. J.; Cenkus, M. A.

1979-01-01

To determine whether sputter etching may provide substantial polymer surface texturing with insignificant changes in chemical and mechanical properties, an 8 cm beam diameter, electron bombardment, argon ion source was used to sputter etch (ion-texture process) nine biomedical polymers. The materials included silicone rubber, 32% carbon impregnated polyolefin, polyoxymethylene, polytetrafluoroethylene, ultrahigh molecular weight (UHMW) polyethylene, UHMW polyethylene with carbon fibers (10%), and several polyurethanes (bioelectric, segmented, and cross linked). Ion textured microtensile specimens of each material except UHMW polyethylene and UHMW polyethylene with 10% carbon fibers were used to determine the effect of ion texturing on tensile properties. Scanning electron microscopy was used to determine surface morphology changes, and electron spectroscopy for chemical analysis was used to analyze the near surface chemical changes that result from ion texturing. Ion energies of 500 eV with beam current densities ranging from 0.08 to 0.19 mA/sq cm were used to ion texture the various materials. Standard microtensile specimens of seven polymers were exposed to a saline environment for 24 hours prior to and during the tensile testing. The surface chemical changes resulting from sputter etching are minimal in spite of the often significant changes in the surface morphology.

Detecting wood surface defects with fusion algorithm of visual saliency and local threshold segmentation

NASA Astrophysics Data System (ADS)

Wang, Xuejuan; Wu, Shuhang; Liu, Yunpeng

2018-04-01

This paper presents a new method for wood defect detection. It can solve the over-segmentation problem existing in local threshold segmentation methods. This method effectively takes advantages of visual saliency and local threshold segmentation. Firstly, defect areas are coarsely located by using spectral residual method to calculate global visual saliency of them. Then, the threshold segmentation of maximum inter-class variance method is adopted for positioning and segmenting the wood surface defects precisely around the coarse located areas. Lastly, we use mathematical morphology to process the binary images after segmentation, which reduces the noise and small false objects. Experiments on test images of insect hole, dead knot and sound knot show that the method we proposed obtains ideal segmentation results and is superior to the existing segmentation methods based on edge detection, OSTU and threshold segmentation.

Lung segmentation refinement based on optimal surface finding utilizing a hybrid desktop/virtual reality user interface.

PubMed

Sun, Shanhui; Sonka, Milan; Beichel, Reinhard R

2013-01-01

Recently, the optimal surface finding (OSF) and layered optimal graph image segmentation of multiple objects and surfaces (LOGISMOS) approaches have been reported with applications to medical image segmentation tasks. While providing high levels of performance, these approaches may locally fail in the presence of pathology or other local challenges. Due to the image data variability, finding a suitable cost function that would be applicable to all image locations may not be feasible. This paper presents a new interactive refinement approach for correcting local segmentation errors in the automated OSF-based segmentation. A hybrid desktop/virtual reality user interface was developed for efficient interaction with the segmentations utilizing state-of-the-art stereoscopic visualization technology and advanced interaction techniques. The user interface allows a natural and interactive manipulation of 3-D surfaces. The approach was evaluated on 30 test cases from 18 CT lung datasets, which showed local segmentation errors after employing an automated OSF-based lung segmentation. The performed experiments exhibited significant increase in performance in terms of mean absolute surface distance errors (2.54±0.75 mm prior to refinement vs. 1.11±0.43 mm post-refinement, p≪0.001). Speed of the interactions is one of the most important aspects leading to the acceptance or rejection of the approach by users expecting real-time interaction experience. The average algorithm computing time per refinement iteration was 150 ms, and the average total user interaction time required for reaching complete operator satisfaction was about 2 min per case. This time was mostly spent on human-controlled manipulation of the object to identify whether additional refinement was necessary and to approve the final segmentation result. The reported principle is generally applicable to segmentation problems beyond lung segmentation in CT scans as long as the underlying segmentation utilizes the OSF framework. The two reported segmentation refinement tools were optimized for lung segmentation and might need some adaptation for other application domains. Copyright © 2013 Elsevier Ltd. All rights reserved.

A novel approach to segmentation and measurement of medical image using level set methods.

PubMed

Chen, Yao-Tien

2017-06-01

The study proposes a novel approach for segmentation and visualization plus value-added surface area and volume measurements for brain medical image analysis. The proposed method contains edge detection and Bayesian based level set segmentation, surface and volume rendering, and surface area and volume measurements for 3D objects of interest (i.e., brain tumor, brain tissue, or whole brain). Two extensions based on edge detection and Bayesian level set are first used to segment 3D objects. Ray casting and a modified marching cubes algorithm are then adopted to facilitate volume and surface visualization of medical-image dataset. To provide physicians with more useful information for diagnosis, the surface area and volume of an examined 3D object are calculated by the techniques of linear algebra and surface integration. Experiment results are finally reported in terms of 3D object extraction, surface and volume rendering, and surface area and volume measurements for medical image analysis. Copyright © 2017 Elsevier Inc. All rights reserved.

Segmentation via fusion of edge and needle map

NASA Astrophysics Data System (ADS)

Ahn, Hong-Young; Tou, Julius T.

1991-03-01

This paper presents an integrated image segmentation method using edge and needle map which compensates deficiencies of using either edge-based approach or region-based approach. Segmentation of an image is the first and most difficult step toward symbolic transformation of a raw image, which is essential in image understanding. In industrial applications, the task is further complicated by the ubiquitous presence of specularity in most industrial parts. Three images taken from three different illumination directions were used to separate specular and Lambertian components in the images. Needle map is generated from Lambertian component images using photometric stereo technique. In one channel, edges are extracted and linked from the averaged Lambertian images providing one source of segmentation. The other channel, Gaussian curvature and mean curvature values are estimated at each pixel from least square local surface fit of needle map. Labeled surface type image is then generated using the signs of Gaussian and mean curvatures, where one of ten surface types is assigned to each pixel. Connected regions of identical surface type pixels provide the first level grouping, a rough initial segmentation. Edge information and initial segmentation of surface type are fed to an integration module which interprets the edges and regions in a consistent way. During interpretation regions are merged or split, edges are discarded or generated depending upon global surface fit error and consistency with neighboring regions. The output of integrated segmentation is an explicit description of surface type and contours of each region which facilitates recognition, localization and attitude determination of objects in the image.

Segmented rail linear induction motor

DOEpatents

Cowan, Jr., Maynard; Marder, Barry M.

1996-01-01

A segmented rail linear induction motor has a segmented rail consisting of a plurality of nonferrous electrically conductive segments aligned along a guideway. The motor further includes a carriage including at least one pair of opposed coils fastened to the carriage for moving the carriage. A power source applies an electric current to the coils to induce currents in the conductive surfaces to repel the coils from adjacent edges of the conductive surfaces.

Split spline screw

NASA Technical Reports Server (NTRS)

Vranish, John M. (Inventor)

1993-01-01

A split spline screw type payload fastener assembly, including three identical male and female type split spline sections, is discussed. The male spline sections are formed on the head of a male type spline driver. Each of the split male type spline sections has an outwardly projecting load baring segment including a convex upper surface which is adapted to engage a complementary concave surface of a female spline receptor in the form of a hollow bolt head. Additionally, the male spline section also includes a horizontal spline releasing segment and a spline tightening segment below each load bearing segment. The spline tightening segment consists of a vertical web of constant thickness. The web has at least one flat vertical wall surface which is designed to contact a generally flat vertically extending wall surface tab of the bolt head. Mutual interlocking and unlocking of the male and female splines results upon clockwise and counter clockwise turning of the driver element.

The SRS (Segmented Rail Surface) railgun: A new approach to restrike control. [Segmented rail surface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parker J.V.

1988-01-01

A Segmented Rail Surface (SRS) structure is described that eliminates restrike arcs by progressively disconnecting segments of the rail surface after the plasma armature has passed. This technique has been demonstrated using the Los Alamos MIDI-2 railgun. Restrike was eliminated in a plasma armature acceleration experiment using metal-foil fuses as opening switches. A plasma velocity increase from 11 to 16 km/s was demonstrated using the SRS technique to eliminate the viscous drag losses associated with the restrike plasma. This technique appears to be a practical option for a laboratory launcher at present and for future multi-shot launchers if appropriate switchesmore » can be developed. 5 refs., 8 figs.« less

The history of late holocene surface-faulting earthquakes on the central segments of the Wasatch fault zone, Utah

USGS Publications Warehouse

Duross, Christopher; Personius, Stephen; Olig, Susan S; Crone, Anthony J.; Hylland, Michael D.; Lund, William R; Schwartz, David P.

2017-01-01

The Wasatch fault (WFZ)—Utah’s longest and most active normal fault—forms a prominent eastern boundary to the Basin and Range Province in northern Utah. To provide paleoseismic data for a Wasatch Front regional earthquake forecast, we synthesized paleoseismic data to define the timing and displacements of late Holocene surface-faulting earthquakes on the central five segments of the WFZ. Our analysis yields revised histories of large (M ~7) surface-faulting earthquakes on the segments, as well as estimates of earthquake recurrence and vertical slip rate. We constrain the timing of four to six earthquakes on each of the central segments, which together yields a history of at least 24 surface-faulting earthquakes since ~6 ka. Using earthquake data for each segment, inter-event recurrence intervals range from about 0.6 to 2.5 kyr, and have a mean of 1.2 kyr. Mean recurrence, based on closed seismic intervals, is ~1.1–1.3 kyr per segment, and when combined with mean vertical displacements per segment of 1.7–2.6 m, yield mean vertical slip rates of 1.3–2.0 mm/yr per segment. These data refine the late Holocene behavior of the central WFZ; however, a significant source of uncertainty is whether structural complexities that define the segments of the WFZ act as hard barriers to ruptures propagating along the fault. Thus, we evaluate fault rupture models including both single-segment and multi-segment ruptures, and define 3–17-km-wide spatial uncertainties in the segment boundaries. These alternative rupture models and segment-boundary zones honor the WFZ paleoseismic data, take into account the spatial and temporal limitations of paleoseismic data, and allow for complex ruptures such as partial-segment and spillover ruptures. Our data and analyses improve our understanding of the complexities in normal-faulting earthquake behavior and provide geological inputs for regional earthquake-probability and seismic hazard assessments.

Exterior Decay of Wood-Plastic Composite Boards: Characterization and Magnetic Resonance Imaging

Treesearch

Rebecca Ibach; Grace Sun; Marek Gnatowski; Jessie Glaeser; Mathew Leung; John Haight

2016-01-01

Magnetic resonance imaging (MRI) was used to evaluate free water content and distribution in wood-plastic composite (WPC) materials decayed during exterior exposure near Hilo, Hawaii. Two segments of the same board blend were selected from 6 commercial decking boards that had fungal fruiting bodies. One of the two board segments was exposed in sun, the other in shadow...

LOGISMOS—Layered Optimal Graph Image Segmentation of Multiple Objects and Surfaces: Cartilage Segmentation in the Knee Joint

PubMed Central

Zhang, Xiangmin; Williams, Rachel; Wu, Xiaodong; Anderson, Donald D.; Sonka, Milan

2011-01-01

A novel method for simultaneous segmentation of multiple interacting surfaces belonging to multiple interacting objects, called LOGISMOS (layered optimal graph image segmentation of multiple objects and surfaces), is reported. The approach is based on the algorithmic incorporation of multiple spatial inter-relationships in a single n-dimensional graph, followed by graph optimization that yields a globally optimal solution. The LOGISMOS method’s utility and performance are demonstrated on a bone and cartilage segmentation task in the human knee joint. Although trained on only a relatively small number of nine example images, this system achieved good performance. Judged by dice similarity coefficients (DSC) using a leave-one-out test, DSC values of 0.84 ± 0.04, 0.80 ± 0.04 and 0.80 ± 0.04 were obtained for the femoral, tibial, and patellar cartilage regions, respectively. These are excellent DSC values, considering the narrow-sheet character of the cartilage regions. Similarly, low signed mean cartilage thickness errors were obtained when compared to a manually-traced independent standard in 60 randomly selected 3-D MR image datasets from the Osteoarthritis Initiative database—0.11 ± 0.24, 0.05 ± 0.23, and 0.03 ± 0.17 mm for the femoral, tibial, and patellar cartilage thickness, respectively. The average signed surface positioning errors for the six detected surfaces ranged from 0.04 ± 0.12 mm to 0.16 ± 0.22 mm. The reported LOGISMOS framework provides robust and accurate segmentation of the knee joint bone and cartilage surfaces of the femur, tibia, and patella. As a general segmentation tool, the developed framework can be applied to a broad range of multiobject multisurface segmentation problems. PMID:20643602

Segmented rail linear induction motor

DOEpatents

Cowan, M. Jr.; Marder, B.M.

1996-09-03

A segmented rail linear induction motor has a segmented rail consisting of a plurality of nonferrous electrically conductive segments aligned along a guideway. The motor further includes a carriage including at least one pair of opposed coils fastened to the carriage for moving the carriage. A power source applies an electric current to the coils to induce currents in the conductive surfaces to repel the coils from adjacent edges of the conductive surfaces. 6 figs.

In vivo assessment of a novel dacron surface with covalently bound recombinant hirudin.

PubMed

Wyers, M C; Phaneuf, M D; Rzucidlo, E M; Contreras, M A; LoGerfo, F W; Quist, W C

1999-01-01

Prosthetic arterial graft surfaces are relatively thrombogenic and fail to heal with a cellular neointima. The goal of this study was to characterize the in vivo antithrombin properties of a novel Dacron surface with covalently linked recombinant hirudin (rHir) implanted in a canine thoracic aorta with high flow and shear rates. rHir was bound to a knitted Dacron patch using crosslinker-modified bovine serum albumin (BSA) as a basecoat protein. BSA was first reacted with the heterobifunctional crosslinker, sulfo-SMCC. This BSA-SMCC complex was then bound to the carboxylic acid groups of hydrolyzed Dacron patches using the carbodiimide crosslinker, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride. Iodinated, Traut's-modified rHir (125I-rHir-SH) was then reacted with the Dacron-BSA-SMCC surface, thereby covalently binding 125I-rHir. Graft segments were washed and sonicated to remove any nonspecifically bound 125I-rHir. Dacron-BSA-SMCC-S-125I-rHir patches (n = 5) and control Dacron-BSA patches (n = 5) were implanted in series in the thoracic aortas of canines. These patches were exposed to nonheparinized, arterial blood flow for 2 hours. Patches were explanted and assessed for 125I-rHir loss. Antithrombin activity of explanted 1-cm2 patch segments was evaluated using a chromogenic assay with 1, 5, 10, 15 units of added thrombin. Light microscopy was performed to qualitatively examine the pseudointima. Two animals were excluded from the study owing to excessive bleeding through the knitted 125I-rHir patch. Comparison of preoperative and postoperative 125I-rHir gamma counts revealed an overall decrease of 20+/-5.4% over the period studied. Explanted 125I-rHir patch segments were able to inhibit 1, 5, and 7 NIHU of thrombin, demonstrating retained antithrombin activity. Gross and microscopic examination of the control and test Dacron surfaces showed marked differences. Dacron surfaces with covalently bound 125I-rHir had no gross thrombus and a thin pseudointima of platelets and plasma proteins. In contrast, the control patches had a thick pseudointima composed of fibrin-rich thrombus. rHir, covalently bound to Dacron patches, maintains its biologic activity as well as prevents thrombus formation on the graft surface. This novel antithrombin coating, by modifying the blood/ graft interface, may improve both short- and long-term patency in small-diameter prosthetic arterial grafts and has applications with respect to other implantable or indwelling biomaterials.

Serially connected solid oxide fuel cells having monolithic cores

DOEpatents

Herceg, J.E.

1985-05-20

Disclosed is a solid oxide fuel cell for electrochemically combining fuel and oxidant for generating galvanic output. The cell core has an array of cell segments electrically serially connected in the flow direction, each segment consisting of electrolyte walls and interconnect that are substantially devoid of any composite inert materials for support. Instead, the core is monolithic, where each electrolyte wall consists of thin layers of cathode and anode materials sandwiching a thin layer of electrolyte material therebetween. Means direct the fuel to the anode-exposed core passageways and means direct the oxidant to the cathode-exposed core passageways; and means also direct the galvanic output to an exterior circuit. Each layer of the electrolyte composite materials is of the order of 0.002 to 0.01 cm thick; and each layer of the cathode and anode materials is of the order of 0.002 to 0.05 cm thick. Between 2 and 50 cell segments may be connected in series.

HOCl causes airway substance P hyperresponsiveness and neutral endopeptidase hypoactivity.

PubMed

Murlas, C G; Murphy, T P; Lang, Z

1990-06-01

We investigated whether exposure of guinea pig tracheal tissue to hypochlorous acid (HOCl) or hydrogen peroxide (H2O2) by perfusion through the airway lumen affected the responsiveness of airway muscle to ACh, KCl, or substance P in the presence or absence of 1 microM phosphoramidon, an inhibitor of neutral endopeptidase (NEP). Pairs of tracheal segments were immersed in a Krebs solution (pH 7.40 at 37 degrees C) and connected to perfusion circuits so that the lumen of one segment of each pair could be perfused with Krebs solution while the other was perfused for the same time (10 min) with either 0.1 microM HOCl or 10 mM H2O2. Segments after perfusion were cut into rings of similar size and placed in muscle chambers so that airway muscle force generation in vitro could be measured on stimulation by cumulative agonist doses. In addition, cell homogenates were made from other, similarly perfused tracheal segments to assess NEP activity using reverse-phase, high-pressure liquid chromatography (HPLC). We found that smooth muscle of mucosa-intact guinea pig airways perfused with HOCl, but not H2O2, was hyperresponsive to substance P but not to ACh or KCl. HOCl-perfused rings were not different from Krebs solution-exposed rings pretreated with phosphoramidon. There was no increase in substance P responsiveness of HOCl-exposed airways in which the mucosa had been removed before testing in vitro. The substance P hyperresponsiveness of HOCl-exposed, mucosa-intact airways was associated with decreased NEP activity.(ABSTRACT TRUNCATED AT 250 WORDS)

Structure, Frictional Melting and Fault Weakening during the 2008 Mw 7.9 Wenchuan Earthquake Slip: Observation from the WFSD Drilling Core Samples

NASA Astrophysics Data System (ADS)

Li, H.; Wang, H.; Li, C.; Zhang, J.; Sun, Z.; Si, J.; Liu, D.; Chevalier, M. L.; Han, L.; Yun, K.; Zheng, Y.

2015-12-01

The 2008 Mw7.9 Wenchuan earthquake produced two co-seismic surface ruptures along Yingxiu-Beichuan fault (~270 km) and the Guanxian-Anxian fault (~80 km) simultaneously in the Longmen Shan thrust belt. Besides, two surface rupture zones were tracked in the southern segment of the Yingxiu-Beichuan rupture zone, one along the Yingxiu fault, the other along the Shenxigou-Longchi fault, which both converged into one rupture zone at the Bajiaomiao village, Hongkou town, where one distinct fault plane with two striation orientations was exposed. The Wenchuan earthquake Fault Scientific Drilling project (WFSD) was carried out right after the earthquake to investigate its faulting mechanisms and rupture process. Six boreholes were drilled along the rupture zones with depths ranging from 600 to 2400 m. WFSD-1 and WFSD-2 are located at the Bajiaomiao area, the southern segment of the Yingxiu-Beichuan rupture zone, while WFSD-4 and WFSD-4S are in the Nanba town area, in the northern part of the rupture zone. Detailed research showed that ~1 mm thick Principal Slip Zone (PSZ) of the Wenchuan earthquake is located at ~589 m-depth in the WFSD-1 cores. Graphite present in the PSZ indicates a low fault strength. Long-term temperature monitoring shows an extremely low fault friction coefficient during the earthquake. Recently, another possible PSZ was found in WFSD-1 cores at ~732 m-depth, with a ~2 mm thick melt layer in the fault gouge, where feldspar was melted but quartz was not, indicating that the frictional melting temperature was 1230°C < T < 1720°C. These two PSZs at depth may correspond to the two co-seismic surface rupture zones. Besides, the Wenchuan earthquake PSZ was also recognized in the WFSD-4S cores, at ~1084 m-depth. About 200-400 μm thick melt layer (fault vein, mainly feldspar), as well as melt injection veins, were observed in the slip zone, where oblique distinct striations were visible on the slip surface. Therefore, there are two PSZs in the shallow crust at the southern segment along the Yingxiu-Beichuan fault, and another one along the northern segment. Melt and graphite in the PSZs indicate that the frictional melting and thermal pressurization are the main fault mechanisms during the Wenchuan earthquake. The melt and graphite can be considered as markers of large earthquakes.

History of late Holocene earthquakes at the Willow Creek site on the Nephi segment, Wasatch fault zone, Utah

USGS Publications Warehouse

Crone, Anthony J.; Personius, Stephen F.; Duross, Christopher; Machette, Michael N.; Mahan, Shannon

2014-01-01

This 43-page report presents new data from the Willow Creek site that provides well-defined and narrow bounds on the times of the three youngest earthquakes on the southern strand of the Nephi segment, Wasatch Fault zone, and refines the time of the youngest earthquake to about 200 years ago. This is the youngest surface rupture on the entire Wasatch fault zone, which occurred about a century or less before European settles arrived in Utah. Two trenches at the Willow Creek site exposed three scarp-derived colluvial wedges that are evidence of three paleoearthquakes. OxCal modeling of ages from Willow Creek indicate that paleoearthquake WC1 occurred at 0.2 ± 0.1 ka, WC2 occurred at 1.2 ± 0.1 ka, and WC3 occurred at 1.9 ± 0.6 ka. Stratigraphic constraints on the time of paleoearthquake WC4 are extremely poor, so OxCal modeling only yields a broadly constrained age of 4.7 ± 1.8 ka. Results from the Willow Creek site significantly refine the times of late Holocene earthquakes on the Southern strand of the Nephi segment, and this result, when combined with a reanalysis of the stratigraphic and chronologic information from previous investigations at North Creek and Red Canyon, yield a stronger basis of correlating individual earthquakes between all three sites.

Renal cortex segmentation using optimal surface search with novel graph construction.

PubMed

Li, Xiuli; Chen, Xinjian; Yao, Jianhua; Zhang, Xing; Tian, Jie

2011-01-01

In this paper, we propose a novel approach to solve the renal cortex segmentation problem, which has rarely been studied. In this study, the renal cortex segmentation problem is handled as a multiple-surfaces extraction problem, which is solved using the optimal surface search method. We propose a novel graph construction scheme in the optimal surface search to better accommodate multiple surfaces. Different surface sub-graphs are constructed according to their properties, and inter-surface relationships are also modeled in the graph. The proposed method was tested on 17 clinical CT datasets. The true positive volume fraction (TPVF) and false positive volume fraction (FPVF) are 74.10% and 0.08%, respectively. The experimental results demonstrate the effectiveness of the proposed method.

Automatic segmentation and reconstruction of the cortex from neonatal MRI.

PubMed

Xue, Hui; Srinivasan, Latha; Jiang, Shuzhou; Rutherford, Mary; Edwards, A David; Rueckert, Daniel; Hajnal, Joseph V

2007-11-15

Segmentation and reconstruction of cortical surfaces from magnetic resonance (MR) images are more challenging for developing neonates than adults. This is mainly due to the dynamic changes in the contrast between gray matter (GM) and white matter (WM) in both T1- and T2-weighted images (T1w and T2w) during brain maturation. In particular in neonatal T2w images WM typically has higher signal intensity than GM. This causes mislabeled voxels during cortical segmentation, especially in the cortical regions of the brain and in particular at the interface between GM and cerebrospinal fluid (CSF). We propose an automatic segmentation algorithm detecting these mislabeled voxels and correcting errors caused by partial volume effects. Our results show that the proposed algorithm corrects errors in the segmentation of both GM and WM compared to the classic expectation maximization (EM) scheme. Quantitative validation against manual segmentation demonstrates good performance (the mean Dice value: 0.758+/-0.037 for GM and 0.794+/-0.078 for WM). The inner, central and outer cortical surfaces are then reconstructed using implicit surface evolution. A landmark study is performed to verify the accuracy of the reconstructed cortex (the mean surface reconstruction error: 0.73 mm for inner surface and 0.63 mm for the outer). Both segmentation and reconstruction have been tested on 25 neonates with the gestational ages ranging from approximately 27 to 45 weeks. This preliminary analysis confirms previous findings that cortical surface area and curvature increase with age, and that surface area scales to cerebral volume according to a power law, while cortical thickness is not related to age or brain growth.

Optimal graph search segmentation using arc-weighted graph for simultaneous surface detection of bladder and prostate.

PubMed

Song, Qi; Wu, Xiaodong; Liu, Yunlong; Smith, Mark; Buatti, John; Sonka, Milan

2009-01-01

We present a novel method for globally optimal surface segmentation of multiple mutually interacting objects, incorporating both edge and shape knowledge in a 3-D graph-theoretic approach. Hard surface interacting constraints are enforced in the interacting regions, preserving the geometric relationship of those partially interacting surfaces. The soft smoothness a priori shape compliance is introduced into the energy functional to provide shape guidance. The globally optimal surfaces can be simultaneously achieved by solving a maximum flow problem based on an arc-weighted graph representation. Representing the segmentation problem in an arc-weighted graph, one can incorporate a wider spectrum of constraints into the formulation, thus increasing segmentation accuracy and robustness in volumetric image data. To the best of our knowledge, our method is the first attempt to introduce the arc-weighted graph representation into the graph-searching approach for simultaneous segmentation of multiple partially interacting objects, which admits a globally optimal solution in a low-order polynomial time. Our new approach was applied to the simultaneous surface detection of bladder and prostate. The result was quite encouraging in spite of the low saliency of the bladder and prostate in CT images.

Geneva mechanism. [including star wheel and driver

NASA Technical Reports Server (NTRS)

Summers, R. H.; Kenney, R. L. (Inventor)

1974-01-01

An improved Geneva mechanism is characterized by a driven star-wheel having a segmented cam-follower surface. Star-wheel driver includes a restraining cam having a segmented cam surface for engaging the cam-follower surface of the star-wheel and antifriction rollers pinned to the restraining cam for engaging the cam-follower surface.

Segmentation of whole cells and cell nuclei from 3-D optical microscope images using dynamic programming.

PubMed

McCullough, D P; Gudla, P R; Harris, B S; Collins, J A; Meaburn, K J; Nakaya, M A; Yamaguchi, T P; Misteli, T; Lockett, S J

2008-05-01

Communications between cells in large part drive tissue development and function, as well as disease-related processes such as tumorigenesis. Understanding the mechanistic bases of these processes necessitates quantifying specific molecules in adjacent cells or cell nuclei of intact tissue. However, a major restriction on such analyses is the lack of an efficient method that correctly segments each object (cell or nucleus) from 3-D images of an intact tissue specimen. We report a highly reliable and accurate semi-automatic algorithmic method for segmenting fluorescence-labeled cells or nuclei from 3-D tissue images. Segmentation begins with semi-automatic, 2-D object delineation in a user-selected plane, using dynamic programming (DP) to locate the border with an accumulated intensity per unit length greater that any other possible border around the same object. Then the two surfaces of the object in planes above and below the selected plane are found using an algorithm that combines DP and combinatorial searching. Following segmentation, any perceived errors can be interactively corrected. Segmentation accuracy is not significantly affected by intermittent labeling of object surfaces, diffuse surfaces, or spurious signals away from surfaces. The unique strength of the segmentation method was demonstrated on a variety of biological tissue samples where all cells, including irregularly shaped cells, were accurately segmented based on visual inspection.

Automatic 3D liver segmentation based on deep learning and globally optimized surface evolution

NASA Astrophysics Data System (ADS)

Hu, Peijun; Wu, Fa; Peng, Jialin; Liang, Ping; Kong, Dexing

2016-12-01

The detection and delineation of the liver from abdominal 3D computed tomography (CT) images are fundamental tasks in computer-assisted liver surgery planning. However, automatic and accurate segmentation, especially liver detection, remains challenging due to complex backgrounds, ambiguous boundaries, heterogeneous appearances and highly varied shapes of the liver. To address these difficulties, we propose an automatic segmentation framework based on 3D convolutional neural network (CNN) and globally optimized surface evolution. First, a deep 3D CNN is trained to learn a subject-specific probability map of the liver, which gives the initial surface and acts as a shape prior in the following segmentation step. Then, both global and local appearance information from the prior segmentation are adaptively incorporated into a segmentation model, which is globally optimized in a surface evolution way. The proposed method has been validated on 42 CT images from the public Sliver07 database and local hospitals. On the Sliver07 online testing set, the proposed method can achieve an overall score of 80.3+/- 4.5 , yielding a mean Dice similarity coefficient of 97.25+/- 0.65 % , and an average symmetric surface distance of 0.84+/- 0.25 mm. The quantitative validations and comparisons show that the proposed method is accurate and effective for clinical application.

Three-dimensional segmentation of luminal and adventitial borders in serial intravascular ultrasound images

NASA Technical Reports Server (NTRS)

Shekhar, R.; Cothren, R. M.; Vince, D. G.; Chandra, S.; Thomas, J. D.; Cornhill, J. F.

1999-01-01

Intravascular ultrasound (IVUS) provides exact anatomy of arteries, allowing accurate quantitative analysis. Automated segmentation of IVUS images is a prerequisite for routine quantitative analyses. We present a new three-dimensional (3D) segmentation technique, called active surface segmentation, which detects luminal and adventitial borders in IVUS pullback examinations of coronary arteries. The technique was validated against expert tracings by computing correlation coefficients (range 0.83-0.97) and William's index values (range 0.37-0.66). The technique was statistically accurate, robust to image artifacts, and capable of segmenting a large number of images rapidly. Active surface segmentation enabled geometrically accurate 3D reconstruction and visualization of coronary arteries and volumetric measurements.

Interactive surface correction for 3D shape based segmentation

NASA Astrophysics Data System (ADS)

Schwarz, Tobias; Heimann, Tobias; Tetzlaff, Ralf; Rau, Anne-Mareike; Wolf, Ivo; Meinzer, Hans-Peter

2008-03-01

Statistical shape models have become a fast and robust method for segmentation of anatomical structures in medical image volumes. In clinical practice, however, pathological cases and image artifacts can lead to local deviations of the detected contour from the true object boundary. These deviations have to be corrected manually. We present an intuitively applicable solution for surface interaction based on Gaussian deformation kernels. The method is evaluated by two radiological experts on segmentations of the liver in contrast-enhanced CT images and of the left heart ventricle (LV) in MRI data. For both applications, five datasets are segmented automatically using deformable shape models, and the resulting surfaces are corrected manually. The interactive correction step improves the average surface distance against ground truth from 2.43mm to 2.17mm for the liver, and from 2.71mm to 1.34mm for the LV. We expect this method to raise the acceptance of automatic segmentation methods in clinical application.

Segmenting the Femoral Head and Acetabulum in the Hip Joint Automatically Using a Multi-Step Scheme

NASA Astrophysics Data System (ADS)

Wang, Ji; Cheng, Yuanzhi; Fu, Yili; Zhou, Shengjun; Tamura, Shinichi

We describe a multi-step approach for automatic segmentation of the femoral head and the acetabulum in the hip joint from three dimensional (3D) CT images. Our segmentation method consists of the following steps: 1) construction of the valley-emphasized image by subtracting valleys from the original images; 2) initial segmentation of the bone regions by using conventional techniques including the initial threshold and binary morphological operations from the valley-emphasized image; 3) further segmentation of the bone regions by using the iterative adaptive classification with the initial segmentation result; 4) detection of the rough bone boundaries based on the segmented bone regions; 5) 3D reconstruction of the bone surface using the rough bone boundaries obtained in step 4) by a network of triangles; 6) correction of all vertices of the 3D bone surface based on the normal direction of vertices; 7) adjustment of the bone surface based on the corrected vertices. We evaluated our approach on 35 CT patient data sets. Our experimental results show that our segmentation algorithm is more accurate and robust against noise than other conventional approaches for automatic segmentation of the femoral head and the acetabulum. Average root-mean-square (RMS) distance from manual reference segmentations created by experienced users was approximately 0.68mm (in-plane resolution of the CT data).

Automated recognition of quasi-planar ignimbrite sheets and paleo-surfaces via robust segmentation of DTM - examples from the Western Cordillera of the Central Andes

NASA Astrophysics Data System (ADS)

Székely, B.; Karátson, D.; Koma, Zs.; Dorninger, P.; Wörner, G.; Brandmeier, M.; Nothegger, C.

2012-04-01

The Western slope of the Central Andes between 22° and 17°S is characterized by large, quasi-planar landforms with tilted ignimbrite surfaces and overlying younger sedimentary deposits (e.g. Nazca, Oxaya, Huaylillas ignimbrites). These surfaces were only modified by tectonic uplift and tilting of the Western Cordillera preserving minor now fossilized drainage systems. Several deep, canyons started to form from about 5 Ma ago. Due to tectonic oversteepening in a arid region of very low erosion rates, gravitational collapses and landslides additionally modified the Andean slope and valley flanks. Large areas of fossil surfaces, however, remain. The age of these surfaces has been dated between 11 Ma and 25 Ma at elevations of 3500 m in the Precordillera and at c. 1000 m near the coast. Due to their excellent preservation, our aim is to identify, delineate, and reconstruct these original ignimbrite and sediment surfaces via a sophisticated evaluation of SRTM DEMs. The technique we use here is a robust morphological segmentation method that is insensitive to a certain amount of outliers, even if they are spatially correlated. This paves the way to identify common local planar features and combine these into larger areas of a particular surface segment. Erosional dissection and faulting, tilting and folding define subdomains, and thus the original quasi-planar surfaces are modified. Additional processes may create younger surfaces, such as sedimentary floodplains and salt pans. The procedure is tuned to provide a distinction of these features. The technique is based on the evaluation of local normal vectors (perpendicular to the actual surface) that are obtained by determination of locally fitting planes. Then, this initial set of normal vectors are gradually classified into groups with similar properties providing candidate point clouds that are quasi co-planar. The quasi co-planar sets of points are analysed further against other criteria, such as number of minimum points, maximized standard deviation of spatial scatter, maximum point-to-plane surface, etc. SRTM DEMs of selected areas of the Western slope of the Central Andes have been processed with various parameter sets. The resulting domain structure shows strong correlation with tectonic features (e.g. faulting) and younger depositional surfaces whereas other segmentation features appear or disappear depending on parameters of the analysis. For example, a fine segmentation results - for a given study area - in ca. 2500 planar features (of course not all are geologically meaningful), whereas a more meaningful result has an order of magnitude less planes, ca. 270. The latter segmentation still covers the key areas, and the dissecting features (e.g., large incised canyons) are typically identified. For the fine segmentation version an area of 3863 km2 is covered by fitted planes for the ignimbrite surfaces, whereas for the more robust segmentation this area is 2555 km2. The same values for the sedimentary surfaces are 3162 km2 and 2080 km2, respectively. The total processed area was 14498 km2. As the previous numbers and the 18,1% and 18,6% decrease in the coverage suggest, the robust segmentation remains meaningful for large parts of the area while the number of planar features decreased by an order of magnitude. This result also emphasizes the importance of the initial parameters. To verify the results in more detail, residuals (difference between measured and modelled elevation) are also evaluated, and the results are fed back to the segmentation procedure. Steeper landscapes (young volcanic edifices) are clearly separated from higher-order (long-wavelength) structures. This method allows to quantitatively identify uniform surface segments and to relate these to geologically and morphologically meaningful parameters (type of depositional surface, rock type, surface age).

Using ergonomics to enhance safe production at a surface coal mine--a case study with powder crews.

PubMed

Torma-Krajewski, Janet; Wiehagen, William; Etcheverry, Ann; Turin, Fred; Unger, Richard

2009-10-01

Job tasks that involve exposure to work-related musculoskeletal disorder (WMSD) risk factors may impact both the risk of injury and production downtime. Common WMSD risks factors associated with mining tasks include forceful exertions, awkward postures, repetitive motion, jolting and jarring, forceful gripping, contact stress, and whole body and segmental vibration. Mining environments that expose workers to temperature/humidity extremes, windy conditions, and slippery and uneven walking surfaces also contribute to injury risk. National Institute for Occupational Safety and Health (NIOSH) researchers worked with powder crew members from the Bridger Coal Company to identify and rank routine work tasks based on perceived exposure to WMSD risk factors. This article presents the process followed to identify tasks that workers believed involved the greatest exposure to risk factors and discusses risk reduction strategies. Specifically, the proposed prill truck design changes addressed cab ingress/egress, loading blast holes, and access to the upper deck of the prill truck.

Folding of a detachment and fault - Modified detachment folding along a lateral ramp, southwestern Montana, USA

NASA Astrophysics Data System (ADS)

Schmidt, Christopher; Whisner, S. Christopher; Whisner, Jennifer B.

2014-12-01

The inversion of the Middle Proterozoic Belt sedimentary basin during Late Cretaceous thrusting in Montana produced a large eastwardly-convex salient, the southern boundary of which is a 200 km-long oblique to lateral ramp subtended by a detachment between the Belt rocks and Archean basement. A 10 km-long lateral ramp segment exposes the upper levels of the detachment where hanging wall Belt rocks have moved out over the Paleozoic and Mesozoic section. The hanging wall structure consists of a train of high amplitude, faulted, asymmetrical detachment folds. Initial west-east shortening produced layer parallel shortening fabrics and dominantly strike slip faulting followed by symmetrical detachment folding. 'Lock-up' of movement on the detachment surface produced regional simple shear and caused the detachment folds to become asymmetrical and faulted. Folding of the detachment surface after lock-up modified the easternmost detachment folds further into a southeast-verging, overturned fold pair with a ramp-related fault along the base of the stretched mutual limb.

Adhesion promotion at a homopolymer-solid interface using random heteropolymers

NASA Astrophysics Data System (ADS)

Simmons, Edward Read; Chakraborty, Arup K.

1998-11-01

We investigate the potential uses for random heteropolymers (RHPs) as adhesion promoters between a homopolymer melt and a solid surface. We consider homopolymers of monomer (segment) type A which are naturally repelled from a solid surface. To this system we add RHPs with both A and B (attractive to the surface) type monomers to promote adhesion between the two incompatible substrates. We employ Monte Carlo simulations to investigate the effects of variations in the sequence statistics of the RHPs, amount of promoter added, and strength of the segment-segment and segment-surface interaction parameters. Clearly, the parameter space in such a system is quite large, but we are able to describe, in a qualitative manner, the optimal parameters for adhesion promotion. The optimal set of parameters yield interfacial conformational statistics for the RHPs which have a relatively high adsorbed fraction and also long loops extending away from the surface that promote entanglements with the bulk homopolymer melt. In addition, we present qualitative evidence that the concentration of RHP segments per surface site plays an important role in determining the mechanism of failure (cohesive versus adhesive) at such an interface. Our results also provide the necessary input for future simulations in which the system may be strained to the limit of fracture.

Optimal Multiple Surface Segmentation With Shape and Context Priors

PubMed Central

Bai, Junjie; Garvin, Mona K.; Sonka, Milan; Buatti, John M.; Wu, Xiaodong

2014-01-01

Segmentation of multiple surfaces in medical images is a challenging problem, further complicated by the frequent presence of weak boundary evidence, large object deformations, and mutual influence between adjacent objects. This paper reports a novel approach to multi-object segmentation that incorporates both shape and context prior knowledge in a 3-D graph-theoretic framework to help overcome the stated challenges. We employ an arc-based graph representation to incorporate a wide spectrum of prior information through pair-wise energy terms. In particular, a shape-prior term is used to penalize local shape changes and a context-prior term is used to penalize local surface-distance changes from a model of the expected shape and surface distances, respectively. The globally optimal solution for multiple surfaces is obtained by computing a maximum flow in a low-order polynomial time. The proposed method was validated on intraretinal layer segmentation of optical coherence tomography images and demonstrated statistically significant improvement of segmentation accuracy compared to our earlier graph-search method that was not utilizing shape and context priors. The mean unsigned surface positioning errors obtained by the conventional graph-search approach (6.30 ± 1.58 μm) was improved to 5.14 ± 0.99 μm when employing our new method with shape and context priors. PMID:23193309

Climbing robot. [caterpillar design

NASA Technical Reports Server (NTRS)

Kerley, James J. (Inventor); May, Edward L. (Inventor); Ecklund, Wayne D. (Inventor)

1993-01-01

A mobile robot for traversing any surface consisting of a number of interconnected segments, each interconnected segment having an upper 'U' frame member, a lower 'U' frame member, a compliant joint between the upper 'U' frame member and the lower 'U' frame member, a number of linear actuators between the two frame members acting to provide relative displacement between the frame members, a foot attached to the lower 'U' frame member for adherence of the segment to the surface, an inter-segment attachment attached to the upper 'U' frame member for interconnecting the segments, a power source connected to the linear actuator, and a computer/controller for independently controlling each linear actuator in each interconnected segment such that the mobile robot moves in a caterpillar like fashion.

The influence of chemical structure on thermal properties and surface morphology of polyurethane materials.

PubMed

Brzeska, Joanna; Morawska, Magda; Heimowska, Aleksandra; Sikorska, Wanda; Wałach, Wojciech; Hercog, Anna; Kowalczuk, Marek; Rutkowska, Maria

2018-01-01

The surface morphology and thermal properties of polyurethanes can be correlated to their chemical composition. The hydrophilicity, surface morphology, and thermal properties of polyurethanes (differed in soft segments and in linear/cross-linked structure) were investigated. The influence of poly([ R , S ]-3-hydroxybutyrate) presence in soft segments and blending of polyurethane with polylactide on surface topography were also estimated. The linear polyurethanes (partially crystalline) had the granular surface, whereas the surface of cross-linked polyurethanes (almost amorphous) was smooth. Round aggregates of polylactide un-uniformly distributed in matrix of polyurethane were clearly visible. It was concluded that some modification of soft segment (by mixing of poly([ R , S ]-3-hydroxybutyrate) with different polydiols and polytriol) and blending of polyurethanes with small amount of polylactide influence on crystallinity and surface topography of obtained polyurethanes.

Embryonic development of a whirligig beetle, Dineutus mellyi, with special reference to external morphology (insecta: Coleoptera, Gyrinidae).

PubMed

Komatsu, Shintaro; Kobayashi, Yukimasa

2012-05-01

The egg morphology and successive changes of developing embryos of the whirligig beetle, Dineutus mellyi (Adephaga: Gyrinidae) are described from observations based on light and scanning electron microscopy. The egg surface is characterized by minute conical projections covering the entire egg surface, a stalk-like micropylar projection at the anterior pole of the egg, and a longitudinal split line along which the chorion is cleaved during the middle embryonic stages. The germ band or embryo is formed on the ventral egg surface, and develops on the surface throughout the egg period; thus, the egg is a superficial type, as is the case in most coleopteran species. A pair of lateral tracheal gills (LTGs) of the first abdominal segment originates from appendage-like projections arising at the lateral side of pleuropodia, and the LTGs of the second to ninth abdominal segments are arranged in a row with that of the first segment. Therefore, LTGs are structures with serial homology. The paired dorsal tracheal gills (DTGs) of the ninth abdominal segment are formed on the regions just latero-dorsal to the LTGs of this segment. Regarding the pleuropodia as the structures being homologous with thoracic legs, neither the LTGs nor DTGs are homologous with thoracic legs, but originate in the more lateral region corresponding to the future pleura of the thoracic segments. The last (10th) abdominal segment in the larva is formed by the fusion of the embryonic 10th and 11th abdominal segments. Four terminal hooks at the end of the last abdominal segment originate from two pairs of swellings on the posterior end of the embryonic 11th abdominal segment. It is proposed that the terminal hooks possibly correspond to the claws of medially fused cerci of the embryonic 11th abdominal segment. Copyright © 2011 Wiley Periodicals, Inc.

Aircraft control system

NASA Technical Reports Server (NTRS)

Kendall, Greg T. (Inventor); Morgan, Walter R. (Inventor)

2010-01-01

A span-loaded, highly flexible flying wing, having horizontal control surfaces mounted aft of the wing on extended beams to form local pitch-control devices. Each of five spanwise wing segments of the wing has one or more motors and photovoltaic arrays, and produces its own lift independent of the other wing segments, to minimize inter-segment loads. Wing dihedral is controlled by separately controlling the local pitch-control devices consisting of a control surface on a boom, such that inboard and outboard wing segment pitch changes relative to each other, and thus relative inboard and outboard lift is varied.

Thoracic cavity segmentation algorithm using multiorgan extraction and surface fitting in volumetric CT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bae, JangPyo; Kim, Namkug, E-mail: namkugkim@gmail.com; Lee, Sang Min

2014-04-15

Purpose: To develop and validate a semiautomatic segmentation method for thoracic cavity volumetry and mediastinum fat quantification of patients with chronic obstructive pulmonary disease. Methods: The thoracic cavity region was separated by segmenting multiorgans, namely, the rib, lung, heart, and diaphragm. To encompass various lung disease-induced variations, the inner thoracic wall and diaphragm were modeled by using a three-dimensional surface-fitting method. To improve the accuracy of the diaphragm surface model, the heart and its surrounding tissue were segmented by a two-stage level set method using a shape prior. To assess the accuracy of the proposed algorithm, the algorithm results ofmore » 50 patients were compared to the manual segmentation results of two experts with more than 5 years of experience (these manual results were confirmed by an expert thoracic radiologist). The proposed method was also compared to three state-of-the-art segmentation methods. The metrics used to evaluate segmentation accuracy were volumetric overlap ratio (VOR), false positive ratio on VOR (FPRV), false negative ratio on VOR (FNRV), average symmetric absolute surface distance (ASASD), average symmetric squared surface distance (ASSSD), and maximum symmetric surface distance (MSSD). Results: In terms of thoracic cavity volumetry, the mean ± SD VOR, FPRV, and FNRV of the proposed method were (98.17 ± 0.84)%, (0.49 ± 0.23)%, and (1.34 ± 0.83)%, respectively. The ASASD, ASSSD, and MSSD for the thoracic wall were 0.28 ± 0.12, 1.28 ± 0.53, and 23.91 ± 7.64 mm, respectively. The ASASD, ASSSD, and MSSD for the diaphragm surface were 1.73 ± 0.91, 3.92 ± 1.68, and 27.80 ± 10.63 mm, respectively. The proposed method performed significantly better than the other three methods in terms of VOR, ASASD, and ASSSD. Conclusions: The proposed semiautomatic thoracic cavity segmentation method, which extracts multiple organs (namely, the rib, thoracic wall, diaphragm, and heart), performed with high accuracy and may be useful for clinical purposes.« less

Method of making segmented pyrolytic graphite sputtering targets

DOEpatents

McKernan, Mark A.; Alford, Craig S.; Makowiecki, Daniel M.; Chen, Chih-Wen

1994-01-01

Anisotropic pyrolytic graphite wafers are oriented and bonded together such that the graphite's high thermal conductivity planes are maximized along the back surface of the segmented pyrolytic graphite target to allow for optimum heat conduction away from the sputter target's sputtering surface and to allow for maximum energy transmission from the target's sputtering surface.

Structure and kinematics of segment-scale crustal accretion processes in Iceland and implications for analogous mid-ocean ridge systems

NASA Astrophysics Data System (ADS)

Siler, Drew Lorenz

2011-12-01

The sub-surface geologic structure of the crust is controlled by the magmatic and tectonic processes that construct the crust during plate spreading. As a result, geologic structure provides constraints on the processes that occur during plate spreading. The crust of the Skagi region of northern Iceland, where this study was focused, was accreted by magmatic construction to Iceland ˜7-10 Ma and subsequently glacially eroded, exhuming ˜1-3 km of structural relief. Continuous spreading-parallel and spreading-orthogonal mountain ranges expose the crust accreted at discrete spreading segments, the fundamental intervals upon which plate spreading and crustal accretion occur. As a result, Skagi is an ideal location to employ geologic structure analysis to study magmatic rifting processes. Within spreading segments structural patterns vary significantly between segment centers and distal fissure swarms. While segment centers are characterized by focused magmatic construction and km-scale sub-volcanic subsidence, fissure swarms are characterized by limited magmatic construction, minor sub-axial subsidence and lateral dike injection. Such along-strike variation indicates that both magma in the upper crust and gabbroic material in the lower crust must be redistributed along-strike within spreading segments during plate spreading. Material flow is directed from beneath segment centers towards distal fissure swarms. At the regional scale, each spreading segment is a structurally discrete interval of Iceland's Neovolcanic Zone. As a result of west-northwestward movement of Iceland relative to the Iceland hotspot, the rift zone axis has progressively relocated to the east-southeast with time, leaving a series of abandoned rift zones throughout western Iceland. A compilation of published K/Ar and 40Ar/39Ar age data and geologic data from across northern Iceland shows that rift relocation occurs via frequent (2-3 Ma), small-scale (˜20 km) rift propagations rather than rare, 100s of km 'rift jumps' as is conventional models suggest. The structure relationships we define in the Icelandic crust are similar to that of other magmatic rift systems including Mid-Ocean Ridges, continental rifts and ancient volcanic rift margins. As such, we suggest that many of the crustal accretion processes we have inferred from Icelandic data may be important in these analogous environments as well.

Automated Bone Segmentation and Surface Evaluation of a Small Animal Model of Post-Traumatic Osteoarthritis.

PubMed

Ramme, Austin J; Voss, Kevin; Lesporis, Jurinus; Lendhey, Matin S; Coughlin, Thomas R; Strauss, Eric J; Kennedy, Oran D

2017-05-01

MicroCT imaging allows for noninvasive microstructural evaluation of mineralized bone tissue, and is essential in studies of small animal models of bone and joint diseases. Automatic segmentation and evaluation of articular surfaces is challenging. Here, we present a novel method to create knee joint surface models, for the evaluation of PTOA-related joint changes in the rat using an atlas-based diffeomorphic registration to automatically isolate bone from surrounding tissues. As validation, two independent raters manually segment datasets and the resulting segmentations were compared to our novel automatic segmentation process. Data were evaluated using label map volumes, overlap metrics, Euclidean distance mapping, and a time trial. Intraclass correlation coefficients were calculated to compare methods, and were greater than 0.90. Total overlap, union overlap, and mean overlap were calculated to compare the automatic and manual methods and ranged from 0.85 to 0.99. A Euclidean distance comparison was also performed and showed no measurable difference between manual and automatic segmentations. Furthermore, our new method was 18 times faster than manual segmentation. Overall, this study describes a reliable, accurate, and automatic segmentation method for mineralized knee structures from microCT images, and will allow for efficient assessment of bony changes in small animal models of PTOA.

Optimal graph based segmentation using flow lines with application to airway wall segmentation.

PubMed

Petersen, Jens; Nielsen, Mads; Lo, Pechin; Saghir, Zaigham; Dirksen, Asger; de Bruijne, Marleen

2011-01-01

This paper introduces a novel optimal graph construction method that is applicable to multi-dimensional, multi-surface segmentation problems. Such problems are often solved by refining an initial coarse surface within the space given by graph columns. Conventional columns are not well suited for surfaces with high curvature or complex shapes but the proposed columns, based on properly generated flow lines, which are non-intersecting, guarantee solutions that do not self-intersect and are better able to handle such surfaces. The method is applied to segment human airway walls in computed tomography images. Comparison with manual annotations on 649 cross-sectional images from 15 different subjects shows significantly smaller contour distances and larger area of overlap than are obtained with recently published graph based methods. Airway abnormality measurements obtained with the method on 480 scan pairs from a lung cancer screening trial are reproducible and correlate significantly with lung function.

Exact analytical modeling of magnetic vector potential in surface inset permanent magnet DC machines considering magnet segmentation

NASA Astrophysics Data System (ADS)

Jabbari, Ali

2018-01-01

Surface inset permanent magnet DC machine can be used as an alternative in automation systems due to their high efficiency and robustness. Magnet segmentation is a common technique in order to mitigate pulsating torque components in permanent magnet machines. An accurate computation of air-gap magnetic field distribution is necessary in order to calculate machine performance. An exact analytical method for magnetic vector potential calculation in surface inset permanent magnet machines considering magnet segmentation has been proposed in this paper. The analytical method is based on the resolution of Laplace and Poisson equations as well as Maxwell equation in polar coordinate by using sub-domain method. One of the main contributions of the paper is to derive an expression for the magnetic vector potential in the segmented PM region by using hyperbolic functions. The developed method is applied on the performance computation of two prototype surface inset magnet segmented motors with open circuit and on load conditions. The results of these models are validated through FEM method.

Ceramic turbine stator vane and shroud support

DOEpatents

Glenn, Robert G.

1981-01-01

A support system for supporting the stationary ceramic vanes and ceramic outer shrouds which define the motive fluid gas path in a gas turbine engine is shown. Each individual segment of the ceramic component whether a vane or shroud segment has an integral radially outwardly projecting stem portion. The stem is enclosed in a split collet member of a high-temperature alloy material having a cavity configured to interlock with the stem portion. The generally cylindrical external surface of the collet engages a mating internal cylindrical surface of an aperture through a supporting arcuate ring segment with mating camming surfaces on the two facing cylindrical surfaces such that radially outward movement of the collet relative to the ring causes the internal cavity of the collet to be reduced in diameter to tightly engage the ceramic stem disposed therein. A portion of the collet extends outwardly through the ring segment opposite the ceramic piece and is threaded for receiving a nut and a compression washer for retaining the collet in the ring segment under a continuous biasing force urging the collet radially outwardly.

Determination of oligomeric chain length distributions at surfaces using ToF-SIMS: segregation effects and polymer properties

NASA Astrophysics Data System (ADS)

Gardella, Joseph A.; Mahoney, Christine M.

2004-06-01

While many XPS and SIMS studies of polymers have detected and quantified segregation of low surface energy blocks or components in copolymers and polymer blends [D. Briggs, in: D.R. Clarke, S. Suresh, I.M. Ward (Eds.), Surface Analysis of Polymers by XPS and Static SIMS, Cambridge University Press, Cambridge, 1998 (Chapter 5).], this paper reports ToF-SIMS studies of direct measurement of the segment length distribution at the surface of siloxane copolymers. These data allow insight into the segregation of particular portions of the oligomeric distribution; specifically, in this study, longer PDMS oligomers segregated at the expense of shorter PDMS chains. We have reported XPS analysis of competitive segregation effects for short PDMS chains [Macromolecules 35 (13) (2002) 5256]. In this study, a series of poly(ureaurethane)-poly(dimethylsiloxane) (PUU-PDMS) copolymers have been synthesized containing varying ratios of G-3 and G-9 (G- X describes the average segment length of the PDMS added), while maintaining a constant overall siloxane weight percentage (10, 30, and 60%). These copolymers were utilized as model systems to study the preferential segregation of certain siloxane segment lengths to the surface over others. ToF-SIMS analysis of PUU-PDMS copolymers has yielded high-mass range copolymer fragmentation patterns containing intact PDMS segments. For the first time, this information is utilized to determine PDMS segment length distributions at the copolymer surface as compared to the bulk. The results show that longer siloxane segment lengths are preferentially segregating to the surface over shorter chain lengths. These results also show the importance of ToF-SIMS and mass spectrometry in the development of new materials containing low molecular weight amino-propyl-terminated siloxanes.

21st Century Lunar Exploration: Advanced Radiation Exposure Assessment

NASA Technical Reports Server (NTRS)

Anderson, Brooke; Clowdsley, Martha; Wilson, John; Nealy, John; Luetke, Nathan

2006-01-01

On January 14, 2004 President George W Bush outlined a new vision for NASA that has humans venturing back to the moon by 2020. With this ambitious goal, new tools and models have been developed to help define and predict the amount of space radiation astronauts will be exposed to during transit and habitation on the moon. A representative scenario is used that includes a trajectory from LEO to a Lunar Base, and simplified CAD models for the transit and habitat structures. For this study galactic cosmic rays, solar proton events, and trapped electron and proton environments are simulated using new dynamic environment models to generate energetic electron, and light and heavy ion fluences. Detailed calculations are presented to assess the human exposure for transit segments and surface stays.

Testing of typical spacecraft materials in a simulated substorm environment

NASA Technical Reports Server (NTRS)

Stevens, N. J.; Berkopec, F. D.; Staskus, J. V.; Blech, R. A.; Narciso, S. J.

1977-01-01

The test specimens were spacecraft paints, silvered Teflon, thermal blankets, and solar array segments. The samples, ranging in size from 300 to 1000 sq cm were exposed to monoenergetic electron energies from 2 to 20 keV at a current density of 1 NA/sq cm. The samples generally behaved as capacitors with strong voltage gradient at their edges. The charging characteristics of the silvered Teflon, Kapton, and solar cell covers were controlled by the secondary emission characteristics. Insulators that did not discharge were the spacecraft paints and the quartz fiber cloth thermal blanket sample. All other samples did experience discharges when the surface voltage reached -8 to -16kV. The discharges were photographed. The breakdown voltage for each sample was determined and the average energy lost in the discharge was computed.

Improvements in analysis techniques for segmented mirror arrays

NASA Astrophysics Data System (ADS)

Michels, Gregory J.; Genberg, Victor L.; Bisson, Gary R.

2016-08-01

The employment of actively controlled segmented mirror architectures has become increasingly common in the development of current astronomical telescopes. Optomechanical analysis of such hardware presents unique issues compared to that of monolithic mirror designs. The work presented here is a review of current capabilities and improvements in the methodology of the analysis of mechanically induced surface deformation of such systems. The recent improvements include capability to differentiate surface deformation at the array and segment level. This differentiation allowing surface deformation analysis at each individual segment level offers useful insight into the mechanical behavior of the segments that is unavailable by analysis solely at the parent array level. In addition, capability to characterize the full displacement vector deformation of collections of points allows analysis of mechanical disturbance predictions of assembly interfaces relative to other assembly interfaces. This capability, called racking analysis, allows engineers to develop designs for segment-to-segment phasing performance in assembly integration, 0g release, and thermal stability of operation. The performance predicted by racking has the advantage of being comparable to the measurements used in assembly of hardware. Approaches to all of the above issues are presented and demonstrated by example with SigFit, a commercially available tool integrating mechanical analysis with optical analysis.

A semi-automatic computer-aided method for surgical template design

NASA Astrophysics Data System (ADS)

Chen, Xiaojun; Xu, Lu; Yang, Yue; Egger, Jan

2016-02-01

This paper presents a generalized integrated framework of semi-automatic surgical template design. Several algorithms were implemented including the mesh segmentation, offset surface generation, collision detection, ruled surface generation, etc., and a special software named TemDesigner was developed. With a simple user interface, a customized template can be semi- automatically designed according to the preoperative plan. Firstly, mesh segmentation with signed scalar of vertex is utilized to partition the inner surface from the input surface mesh based on the indicated point loop. Then, the offset surface of the inner surface is obtained through contouring the distance field of the inner surface, and segmented to generate the outer surface. Ruled surface is employed to connect inner and outer surfaces. Finally, drilling tubes are generated according to the preoperative plan through collision detection and merging. It has been applied to the template design for various kinds of surgeries, including oral implantology, cervical pedicle screw insertion, iliosacral screw insertion and osteotomy, demonstrating the efficiency, functionality and generality of our method.

A semi-automatic computer-aided method for surgical template design

PubMed Central

Chen, Xiaojun; Xu, Lu; Yang, Yue; Egger, Jan

2016-01-01

This paper presents a generalized integrated framework of semi-automatic surgical template design. Several algorithms were implemented including the mesh segmentation, offset surface generation, collision detection, ruled surface generation, etc., and a special software named TemDesigner was developed. With a simple user interface, a customized template can be semi- automatically designed according to the preoperative plan. Firstly, mesh segmentation with signed scalar of vertex is utilized to partition the inner surface from the input surface mesh based on the indicated point loop. Then, the offset surface of the inner surface is obtained through contouring the distance field of the inner surface, and segmented to generate the outer surface. Ruled surface is employed to connect inner and outer surfaces. Finally, drilling tubes are generated according to the preoperative plan through collision detection and merging. It has been applied to the template design for various kinds of surgeries, including oral implantology, cervical pedicle screw insertion, iliosacral screw insertion and osteotomy, demonstrating the efficiency, functionality and generality of our method. PMID:26843434

A semi-automatic computer-aided method for surgical template design.

PubMed

Chen, Xiaojun; Xu, Lu; Yang, Yue; Egger, Jan

2016-02-04

This paper presents a generalized integrated framework of semi-automatic surgical template design. Several algorithms were implemented including the mesh segmentation, offset surface generation, collision detection, ruled surface generation, etc., and a special software named TemDesigner was developed. With a simple user interface, a customized template can be semi- automatically designed according to the preoperative plan. Firstly, mesh segmentation with signed scalar of vertex is utilized to partition the inner surface from the input surface mesh based on the indicated point loop. Then, the offset surface of the inner surface is obtained through contouring the distance field of the inner surface, and segmented to generate the outer surface. Ruled surface is employed to connect inner and outer surfaces. Finally, drilling tubes are generated according to the preoperative plan through collision detection and merging. It has been applied to the template design for various kinds of surgeries, including oral implantology, cervical pedicle screw insertion, iliosacral screw insertion and osteotomy, demonstrating the efficiency, functionality and generality of our method.

High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticles.

PubMed

Li, Fuhai; Zhou, Xiaobo; Zhu, Jinmin; Ma, Jinwen; Huang, Xudong; Wong, Stephen T C

2007-10-09

High content screening (HCS)-based image analysis is becoming an important and widely used research tool. Capitalizing this technology, ample cellular information can be extracted from the high content cellular images. In this study, an automated, reliable and quantitative cellular image analysis system developed in house has been employed to quantify the toxic responses of human H4 neuroglioma cells exposed to metal oxide nanoparticles. This system has been proved to be an essential tool in our study. The cellular images of H4 neuroglioma cells exposed to different concentrations of CuO nanoparticles were sampled using IN Cell Analyzer 1000. A fully automated cellular image analysis system has been developed to perform the image analysis for cell viability. A multiple adaptive thresholding method was used to classify the pixels of the nuclei image into three classes: bright nuclei, dark nuclei, and background. During the development of our image analysis methodology, we have achieved the followings: (1) The Gaussian filtering with proper scale has been applied to the cellular images for generation of a local intensity maximum inside each nucleus; (2) a novel local intensity maxima detection method based on the gradient vector field has been established; and (3) a statistical model based splitting method was proposed to overcome the under segmentation problem. Computational results indicate that 95.9% nuclei can be detected and segmented correctly by the proposed image analysis system. The proposed automated image analysis system can effectively segment the images of human H4 neuroglioma cells exposed to CuO nanoparticles. The computational results confirmed our biological finding that human H4 neuroglioma cells had a dose-dependent toxic response to the insult of CuO nanoparticles.

Leaf seal for inner and outer casings of a turbine

DOEpatents

Schroder, Mark Stewart; Leach, David

2002-01-01

A plurality of arcuate, circumferentially extending leaf seal segments form an annular seal spanning between annular sealing surfaces of inner and outer casings of a turbine. The ends of the adjoining seal segments have circumferential gaps to enable circumferential expansion and contraction of the segments. The end of a first segment includes a tab projecting into a recess of a second end of a second segment. Edges of the tab seal against the sealing surfaces of the inner and outer casings have a narrow clearance with opposed edges of the recess. An overlying cover plate spans the joint. Leakage flow is maintained at a minimum because of the reduced gap between the radially spaced edges of the tab and recess, while the seal segments retain the capacity to expand and contract circumferentially.

Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Flow Direction Reversal

PubMed Central

Heuslein, Joshua L.; Meisner, Joshua K.; Li, Xuanyue; Song, Ji; Vincentelli, Helena; Leiphart, Ryan J.; Ames, Elizabeth G.; Price, Richard J.

2015-01-01

Objective Collateral arteriogenesis, the growth of existing arterial vessels to a larger diameter, is a fundamental adaptive response that is often critical for the perfusion and survival of tissues downstream of chronic arterial occlusion(s). Shear stress regulates arteriogenesis; however, the arteriogenic significance of flow direction reversal, occurring in numerous collateral artery segments after femoral artery ligation (FAL), is unknown. Our objective was to determine if flow direction reversal in collateral artery segments differentially regulates endothelial cell signaling and arteriogenesis. Approach and Results Collateral segments experiencing flow reversal after FAL in C57BL/6 mice exhibit increased pericollateral macrophage recruitment, amplified arteriogenesis (30% diameter and 2.8-fold conductance increases), and remarkably permanent (12 weeks post-FAL) remodeling. Genome-wide transcriptional analyses on HUVECs exposed to flow reversal conditions mimicking those occurring in-vivo yielded 10-fold more significantly regulated transcripts, as well as enhanced activation of upstream regulators (NFκB, VEGF, FGF2, TGFβ) and arteriogenic canonical pathways (PKA, PDE, MAPK). Augmented expression of key pro-arteriogenic molecules (KLF2, ICAM-1, eNOS) was also verified by qRT-PCR, leading us to test whether ICAM-1 and/or eNOS regulate amplified arteriogenesis in flow-reversed collateral segments in-vivo. Interestingly, enhanced pericollateral macrophage recruitment and amplified arteriogenesis was attenuated in flow-reversed collateral segments after FAL in ICAM-1−/− mice; however, eNOS−/− mice showed no such differences. Conclusions Flow reversal leads to a broad amplification of pro-arteriogenic endothelial signaling and a sustained ICAM-1-dependent augmentation of arteriogenesis. Further investigation of the endothelial mechanotransduction pathways activated by flow reversal may lead to more effective and durable therapeutic options for arterial occlusive diseases. PMID:26338297

Surface-region context in optimal multi-object graph-based segmentation: robust delineation of pulmonary tumors.

PubMed

Song, Qi; Chen, Mingqing; Bai, Junjie; Sonka, Milan; Wu, Xiaodong

2011-01-01

Multi-object segmentation with mutual interaction is a challenging task in medical image analysis. We report a novel solution to a segmentation problem, in which target objects of arbitrary shape mutually interact with terrain-like surfaces, which widely exists in the medical imaging field. The approach incorporates context information used during simultaneous segmentation of multiple objects. The object-surface interaction information is encoded by adding weighted inter-graph arcs to our graph model. A globally optimal solution is achieved by solving a single maximum flow problem in a low-order polynomial time. The performance of the method was evaluated in robust delineation of lung tumors in megavoltage cone-beam CT images in comparison with an expert-defined independent standard. The evaluation showed that our method generated highly accurate tumor segmentations. Compared with the conventional graph-cut method, our new approach provided significantly better results (p < 0.001). The Dice coefficient obtained by the conventional graph-cut approach (0.76 +/- 0.10) was improved to 0.84 +/- 0.05 when employing our new method for pulmonary tumor segmentation.

3D Segmentation of Maxilla in Cone-beam Computed Tomography Imaging Using Base Invariant Wavelet Active Shape Model on Customized Two-manifold Topology

PubMed Central

Chang, Yu-Bing; Xia, James J.; Yuan, Peng; Kuo, Tai-Hong; Xiong, Zixiang; Gateno, Jaime; Zhou, Xiaobo

2013-01-01

Recent advances in cone-beam computed tomography (CBCT) have rapidly enabled widepsread applications of dentomaxillofacial imaging and orthodontic practices in the past decades due to its low radiation dose, high spatial resolution, and accessibility. However, low contrast resolution in CBCT image has become its major limitation in building skull models. Intensive hand-segmentation is usually required to reconstruct the skull models. One of the regions affected by this limitation the most is the thin bone images. This paper presents a novel segmentation approach based on wavelet density model (WDM) for a particular interest in the outer surface of anterior wall of maxilla. Nineteen CBCT datasets are used to conduct two experiments. This mode-based segmentation approach is validated and compared with three different segmentation approaches. The results show that the performance of this model-based segmentation approach is better than those of the other approaches. It can achieve 0.25 ± 0.2mm of surface error from ground truth of bone surface. PMID:23694914

Method of making segmented pyrolytic graphite sputtering targets

DOEpatents

McKernan, M.A.; Alford, C.S.; Makowiecki, D.M.; Chen, C.W.

1994-02-08

Anisotropic pyrolytic graphite wafers are oriented and bonded together such that the graphite's high thermal conductivity planes are maximized along the back surface of the segmented pyrolytic graphite target to allow for optimum heat conduction away from the sputter target's sputtering surface and to allow for maximum energy transmission from the target's sputtering surface. 2 figures.

Incorporation of physical constraints in optimal surface search for renal cortex segmentation

NASA Astrophysics Data System (ADS)

Li, Xiuli; Chen, Xinjian; Yao, Jianhua; Zhang, Xing; Tian, Jie

2012-02-01

In this paper, we propose a novel approach for multiple surfaces segmentation based on the incorporation of physical constraints in optimal surface searching. We apply our new approach to solve the renal cortex segmentation problem, an important but not sufficiently researched issue. In this study, in order to better restrain the intensity proximity of the renal cortex and renal column, we extend the optimal surface search approach to allow for varying sampling distance and physical separation constraints, instead of the traditional fixed sampling distance and numerical separation constraints. The sampling distance of each vertex-column is computed according to the sparsity of the local triangular mesh. Then the physical constraint learned from a priori renal cortex thickness is applied to the inter-surface arcs as the separation constraints. Appropriate varying sampling distance and separation constraints were learnt from 6 clinical CT images. After training, the proposed approach was tested on a test set of 10 images. The manual segmentation of renal cortex was used as the reference standard. Quantitative analysis of the segmented renal cortex indicates that overall segmentation accuracy was increased after introducing the varying sampling distance and physical separation constraints (the average true positive volume fraction (TPVF) and false positive volume fraction (FPVF) were 83.96% and 2.80%, respectively, by using varying sampling distance and physical separation constraints compared to 74.10% and 0.18%, respectively, by using fixed sampling distance and numerical separation constraints). The experimental results demonstrated the effectiveness of the proposed approach.

Shape-driven 3D segmentation using spherical wavelets.

PubMed

Nain, Delphine; Haker, Steven; Bobick, Aaron; Tannenbaum, Allen

2006-01-01

This paper presents a novel active surface segmentation algorithm using a multiscale shape representation and prior. We define a parametric model of a surface using spherical wavelet functions and learn a prior probability distribution over the wavelet coefficients to model shape variations at different scales and spatial locations in a training set. Based on this representation, we derive a parametric active surface evolution using the multiscale prior coefficients as parameters for our optimization procedure to naturally include the prior in the segmentation framework. Additionally, the optimization method can be applied in a coarse-to-fine manner. We apply our algorithm to the segmentation of brain caudate nucleus, of interest in the study of schizophrenia. Our validation shows our algorithm is computationally efficient and outperforms the Active Shape Model algorithm by capturing finer shape details.

Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption.

PubMed

Perkins, Guy A; Scott, Ray; Perez, Alex; Ellisman, Mark H; Johnson, Jerry E; Fox, Donald A

2012-01-01

Postnatal lead exposure produces rod-selective and Bax-mediated apoptosis, decreased scotopic electroretinograms (ERGs), and scotopic and mesopic vision deficits in humans and/or experimental animals. Rod, but not cone, inner segment mitochondria were considered the primary site of action. However, photoreceptor synaptic mitochondria were not examined. Thus, our experiments investigated the structural and functional effects of environmentally relevant postnatal lead exposure on rod spherule and cone pedicle mitochondria and whether Bcl-xL overexpression provided neuroprotection. C57BL/6N mice pups were exposed to lead only during lactation via dams drinking water containing lead acetate. The blood [Pb] at weaning was 20.6±4.7 µg/dl, which decreased to the control value by 2 months. To assess synaptic mitochondrial structural differences and vulnerability to lead exposure, wild-type and transgenic mice overexpressing Bcl-xL in photoreceptors were used. Electron microscopy, three-dimensional electron tomography, and retinal and photoreceptor synaptic terminal oxygen consumption (QO(2)) studies were conducted in adult control, Bcl-xL, lead, and Bcl-xL/lead mice. The spherule and pedicle mitochondria in lead-treated mice were swollen, and the cristae structure was markedly changed. In the lead-treated mice, the mitochondrial cristae surface area and volume (abundance: measure correlated with ATP (ATP) synthesis) were decreased in the spherules and increased in the pedicles. Pedicles also had an increased number of crista segments per volume. In the lead-treated mice, the number of segments/crista and fraction of cristae with multiple segments (branching) similarly increased in spherule and pedicle mitochondria. Lead-induced remodeling of spherule mitochondria produced smaller cristae with more branching, whereas pedicle mitochondria had larger cristae with more branching and increased crista junction (CJ) diameter. Lead decreased dark- and light-adapted photoreceptor and dark-adapted photoreceptor synaptic terminal QO(2). Bcl-xL partially blocked many of the lead-induced alterations relative to controls. However, spherules still had partially decreased abundance, whereas pedicles still had increased branching, increased crista segments per volume, and increased crista junction diameter. Moreover, photoreceptor and synaptic QO(2) were only partially recovered. These findings reveal cellular and compartmental specific differences in the structure and vulnerability of rod and cone inner segment and synaptic mitochondria to postnatal lead exposure. Spherule and pedicle mitochondria in lead-exposed mice displayed complex and distinguishing patterns of cristae and matrix damage and remodeling consistent with studies showing that synaptic mitochondria are more sensitive to Ca(2+) overload, oxidative stress, and ATP loss than non-synaptic mitochondria. The lead-induced decreases in QO(2) likely resulted from the decreased spherule cristae abundance and smaller cristae, perhaps due to Bax-mediated effects as they occurred in apoptotic rod inner segments. The increase in pedicle cristae abundance and CJ diameter could have resulted from increased Drp1-mediated fission, as small mitochondrial fragments were observed. The mechanisms of Bcl-xL-mediated remodeling might occur via interaction with formation of CJ protein 1 (Fcj1), whereas the partial protection of synaptic QO(2) might result from the enhanced efficiency of energy metabolism via Bcl-xL's direct interaction with the F1F0 ATP synthase and/or regulation of cellular redox status. These lead-induced alterations in photoreceptor synaptic terminal mitochondria likely underlie the persistent scotopic and mesopic deficits in lead-exposed children, workers, and experimental animals. Our findings stress the clinical and scientific importance of examining synaptic dysfunction following injury or disease during development, and developing therapeutic treatments that prevent synaptic degeneration in retinal and neurodegenerative disorders even when apoptosis is blocked.

Active Dihedral Control System for a Torsionally Flexible Wing

NASA Technical Reports Server (NTRS)

Morgan, Walter R. (Inventor); Kendall, Greg T. (Inventor); Lisoski, Derek L. (Inventor); Griecci, John A. (Inventor)

2017-01-01

A span-loaded, highly flexible flying wing, having horizontal control surfaces mounted aft of the wing on extended beams to form local pitch-control devices. Each of five spanwise wing segments of the wing has one or more motors and photovoltaic arrays, and produces its own lift independent of the other wing segments, to minimize inter-segment loads. Wing dihedral is controlled by separately controlling the local pitch-control devices consisting of a control surface on a boom, such that inboard and outboard wing segment pitch changes relative to each other, and thus relative inboard and outboard lift is varied.

Active Dihedral Control System for a Torisionally Flexible Wing

NASA Technical Reports Server (NTRS)

Kendall, Greg T. (Inventor); Lisoski, Derek L. (Inventor); Morgan, Walter R. (Inventor); Griecci, John A. (Inventor)

2015-01-01

A span-loaded, highly flexible flying wing, having horizontal control surfaces mounted aft of the wing on extended beams to form local pitch-control devices. Each of five spanwise wing segments of the wing has one or more motors and photovoltaic arrays, and produces its own lift independent of the other wing segments, to minimize inter-segment loads. Wing dihedral is controlled by separately controlling the local pitch-control devices consisting of a control surface on a boom, such that inboard and outboard wing segment pitch changes relative to each other, and thus relative inboard and outboard lift is varied.

GIS Spatial Analysis of Water Quality at Courtland Creek in Oakland, California

NASA Astrophysics Data System (ADS)

Matias, F.; Perez, L.; Martinez, E.; Rivera Soto, E.; McDonald, K.; Garcia, D.; Ruiz, I.

2015-12-01

Courtland Creek is a channelized stream that traverses residential and industrial sections of East Oakland, California. Segments of the creek are exposed on the surface and have been designated as City of Oakland park land. Since 2012, the quality of creek waters has been monitored through measurement and analysis of nutrient and other possible contaminant levels in samples collected in these exposed segments. Throughout the three-year period during which monitoring efforts have been undertaken, high concentration levels of nitrate have been observed. The primary aim of our research is to gain an overall indication of creek health in relation to its surrounding environment through the use of Geographic Information Systems (GIS) analysis of nutrient concentrations at the four sites. Investigating the relationship between Courtland Creek and the environmental factors influencing its health will enable us to develop a better sense of the actions that can be taken by the City of Oakland to create sustainable park land and healthy communities. During the summer of 2015, our group continued to monitor levels of ammonia, phosphate and nitrate at four different sites along the creek, and benthic macroinvertebrates were sampled at one of these sites. Preliminary analysis of benthic macroinvertebrate data indicates that Courtland Creek is in poor health ecologically. Nitrate concentration levels measured during the study period were lower than those detected in previous years but still indicate inputs other than those associated with natural processes. The high nitrate concentration levels may be the result of human and animal waste pollution, as supported by data obtained during a recent Environmental Protection Agency (EPA) - led E. coli survey that included the watershed within which Courtland Creek is situated.

Body Segment Differences in Surface Area, Skin Temperature and 3D Displacement and the Estimation of Heat Balance during Locomotion in Hominins

PubMed Central

Cross, Alan; Collard, Mark; Nelson, Andrew

2008-01-01

The conventional method of estimating heat balance during locomotion in humans and other hominins treats the body as an undifferentiated mass. This is problematic because the segments of the body differ with respect to several variables that can affect thermoregulation. Here, we report a study that investigated the impact on heat balance during locomotion of inter-segment differences in three of these variables: surface area, skin temperature and rate of movement. The approach adopted in the study was to generate heat balance estimates with the conventional method and then compare them with heat balance estimates generated with a method that takes into account inter-segment differences in surface area, skin temperature and rate of movement. We reasoned that, if the hypothesis that inter-segment differences in surface area, skin temperature and rate of movement affect heat balance during locomotion is correct, the estimates yielded by the two methods should be statistically significantly different. Anthropometric data were collected on seven adult male volunteers. The volunteers then walked on a treadmill at 1.2 m/s while 3D motion capture cameras recorded their movements. Next, the conventional and segmented methods were used to estimate the volunteers' heat balance while walking in four ambient temperatures. Lastly, the estimates produced with the two methods were compared with the paired t-test. The estimates of heat balance during locomotion yielded by the two methods are significantly different. Those yielded by the segmented method are significantly lower than those produced by the conventional method. Accordingly, the study supports the hypothesis that inter-segment differences in surface area, skin temperature and rate of movement impact heat balance during locomotion. This has important implications not only for current understanding of heat balance during locomotion in hominins but also for how future research on this topic should be approached. PMID:18560580

Body segment differences in surface area, skin temperature and 3D displacement and the estimation of heat balance during locomotion in hominins.

PubMed

Cross, Alan; Collard, Mark; Nelson, Andrew

2008-06-18

The conventional method of estimating heat balance during locomotion in humans and other hominins treats the body as an undifferentiated mass. This is problematic because the segments of the body differ with respect to several variables that can affect thermoregulation. Here, we report a study that investigated the impact on heat balance during locomotion of inter-segment differences in three of these variables: surface area, skin temperature and rate of movement. The approach adopted in the study was to generate heat balance estimates with the conventional method and then compare them with heat balance estimates generated with a method that takes into account inter-segment differences in surface area, skin temperature and rate of movement. We reasoned that, if the hypothesis that inter-segment differences in surface area, skin temperature and rate of movement affect heat balance during locomotion is correct, the estimates yielded by the two methods should be statistically significantly different. Anthropometric data were collected on seven adult male volunteers. The volunteers then walked on a treadmill at 1.2 m/s while 3D motion capture cameras recorded their movements. Next, the conventional and segmented methods were used to estimate the volunteers' heat balance while walking in four ambient temperatures. Lastly, the estimates produced with the two methods were compared with the paired t-test. The estimates of heat balance during locomotion yielded by the two methods are significantly different. Those yielded by the segmented method are significantly lower than those produced by the conventional method. Accordingly, the study supports the hypothesis that inter-segment differences in surface area, skin temperature and rate of movement impact heat balance during locomotion. This has important implications not only for current understanding of heat balance during locomotion in hominins but also for how future research on this topic should be approached.

Composition and diameter modulation of magnetic nanowire arrays fabricated by a novel approach

NASA Astrophysics Data System (ADS)

Shaker Salem, Mohamed; Tejo, Felipe; Zierold, Robert; Sergelius, Philip; Montero Moreno, Josep M.; Goerlitz, Detlef; Nielsch, Kornelius; Escrig, Juan

2018-02-01

Straight magnetic nanowires composed of nickel and permalloy segments having different diameters are synthesized using a promising approach. This approach involves the controlled electrodeposition of each magnetic material into specially designed diameter-modulated porous alumina templates. Standard alumina templates are exposed to pore widening followed by a protective coating of the pore wall with ultrathin silica and further anodization. Micromagnetic simulations are employed to investigate the process of magnetization reversal in the fabricated nanowires when the magnetic materials exchange their places in the thick and thin segments. It is found that the magnetization reversal occurs by the propagation of transverse domain wall (DW) when the thick segment is composed of permalloy. However, the reversal process proceeds by the propagation of vortex DW when permalloy is located at the thin segment.

Three-dimensional choroidal segmentation in spectral OCT volumes using optic disc prior information

NASA Astrophysics Data System (ADS)

Hu, Zhihong; Girkin, Christopher A.; Hariri, Amirhossein; Sadda, SriniVas R.

2016-03-01

Recently, much attention has been focused on determining the role of the peripapillary choroid - the layer between the outer retinal pigment epithelium (RPE)/Bruchs membrane (BM) and choroid-sclera (C-S) junction, whether primary or secondary in the pathogenesis of glaucoma. However, the automated choroidal segmentation in spectral-domain optical coherence tomography (SD-OCT) images of optic nerve head (ONH) has not been reported probably due to the fact that the presence of the BM opening (BMO, corresponding to the optic disc) can deflect the choroidal segmentation from its correct position. The purpose of this study is to develop a 3D graph-based approach to identify the 3D choroidal layer in ONH-centered SD-OCT images using the BMO prior information. More specifically, an initial 3D choroidal segmentation was first performed using the 3D graph search algorithm. Note that varying surface interaction constraints based on the choroidal morphological model were applied. To assist the choroidal segmentation, two other surfaces of internal limiting membrane and innerouter segment junction were also segmented. Based on the segmented layer between the RPE/BM and C-S junction, a 2D projection map was created. The BMO in the projection map was detected by a 2D graph search. The pre-defined BMO information was then incorporated into the surface interaction constraints of the 3D graph search to obtain more accurate choroidal segmentation. Twenty SD-OCT images from 20 healthy subjects were used. The mean differences of the choroidal borders between the algorithm and manual segmentation were at a sub-voxel level, indicating a high level segmentation accuracy.

A figure control sensor for the Large Deployable Reflector (LDR)

NASA Technical Reports Server (NTRS)

Bartman, R.; Dubovitsky, S.

1988-01-01

A sensing and control system is required to maintain high optical figure quality in a segmented reflector. Upon detecting a deviation of the segmented surface from its ideal form, the system drives segment mounted actuators to realign the individual segments and thereby return the surface to its intended figure. When the reflector is in use, a set of figure sensors will determine positions of a number of points on the back surface of each of the reflector's segments, each sensor being assigned to a single point. By measuring the positional deviations of these points from previously established nominal values, the figure sensors provide the control system with the information required to maintain the reflector's optical figure. The optical lever, multiple wavelength interferometer, and electronic capacitive sensor, the most promising technologies for the development of the figure sensor, are illustrated. It is concluded that to select a particular implementation of the figure sensors, performance requirement will be refined and relevant technologies investigated further.

Along-Strike Variation in Geometry and Kinematics of a Major, Active Intracontinental Thrust System: the Pred-Terskey Fault Zone, Kyrgyz Tien Shan, Central Asia

NASA Astrophysics Data System (ADS)

Burgette, R. J.; Weldon, R. J.; Abdrakhmatov, K. Y.; Ormukov, C.

2004-12-01

The Pred-Terskey fault zone defines the southern margin of the Issyk-Kul basin, extending eastward over 250 km from at least the Chu River to the Kazakhstan border, and appears to be one of the most active zones in the Kyrgyz Tien Shan. Despite a diversity of structural styles and changes of vergence at the surface, the lateral continuity and overall geometry of the zone is consistent with a single north vergent thrust at depth, which uplifts the Terskey Range and generally tilts the south margin of the basin to the north. This northward tilting of the margin is probably due to a flattening of the fault as it approaches the surface. In spite of historical quiescence, it is likely capable of producing great earthquakes. We have conducted detailed field mapping coupled with terrace profiling and dating at seven representative, well-exposed areas of the fault zone. Based on these field observations and satellite image and air photo interpretation along the entire zone, we identify three major divisions in structural style expressed at the surface. The western segment is typified by the Tura-Su, Ak-Terek and Ton areas. A series of left-stepping, south-vergent, basement-involved reverse faults and folds are uplifting the southern margin of the Issyk-Kul basin in this area. The resulting uphill-facing scarps have trapped and diverted many of the rivers flowing north from the Terskey Range. Tertiary strata and Quaternary geomorphic surfaces show consistent, progressive northward tilting across the entire zone. The west-central segment is represented by the Kajy-Say area. South-vergent reverse faults and a north-vergent backthrust have uplifted an arcuate granite block. Offshore of this area, the lake floor descends to a sharp break in slope with a low relief area at a depth of about 650 m. Late Quaternary geomorphic features do not show evidence of tilting. In contrast to the areas east and west, the major north-dipping thrust is likely planar over this segment and daylights at the lake floor break in slope. The east-central segment is exemplified by the Barskaun and Jety Oguz areas. A high angle reverse fault juxtaposes Paleozoic rock against Tertiary sediments. To the north, a thrust fault with a sinuous trace places north-dipping Tertiary rock over the nearly horizontal basin floor. Quaternary terraces in the hanging wall of this fault record progressive northward tilting. North of the thrust fault a series of anticlines are growing out of the basin sediments. The eastern segment, which includes the Jergalan River valley, lacks a low angle thrust fault at the basin margin. Along this segment, the basement reverse fault uplifts Paleozoic rock against Quaternary basin sediment. To the north of this range-bounding structure, late Quaternary terraces are offset by south-vergent scarps. We are calculating geologic slip rates for each of the seven sites along the Pred-Terskey zone by dating terraces and constructing structural models consistent with both the rock and terrace records. Based on preliminary radiocarbon dates, a prominent Jety Oguz River terrace is 50 +/- 10 ka. The terrace is tilted 0.5° relative to the modern river, and with the low angle fault branching off of the basement reverse fault at dips ranging between 45° and 90° , the slip rate of this fault is 6 +/- 4 mm/yr. This is consistent with the GPS shortening rate across the Pred-Terskey zone at this longitude.

A Complete System for Automatic Extraction of Left Ventricular Myocardium From CT Images Using Shape Segmentation and Contour Evolution

PubMed Central

Zhu, Liangjia; Gao, Yi; Appia, Vikram; Yezzi, Anthony; Arepalli, Chesnal; Faber, Tracy; Stillman, Arthur; Tannenbaum, Allen

2014-01-01

The left ventricular myocardium plays a key role in the entire circulation system and an automatic delineation of the myocardium is a prerequisite for most of the subsequent functional analysis. In this paper, we present a complete system for an automatic segmentation of the left ventricular myocardium from cardiac computed tomography (CT) images using the shape information from images to be segmented. The system follows a coarse-to-fine strategy by first localizing the left ventricle and then deforming the myocardial surfaces of the left ventricle to refine the segmentation. In particular, the blood pool of a CT image is extracted and represented as a triangulated surface. Then, the left ventricle is localized as a salient component on this surface using geometric and anatomical characteristics. After that, the myocardial surfaces are initialized from the localization result and evolved by applying forces from the image intensities with a constraint based on the initial myocardial surface locations. The proposed framework has been validated on 34-human and 12-pig CT images, and the robustness and accuracy are demonstrated. PMID:24723531

High temperature control rod assembly

DOEpatents

Vollman, Russell E.

1991-01-01

A high temperature nuclear control rod assembly comprises a plurality of substantially cylindrical segments flexibly joined together in succession by ball joints. The segments are made of a high temperature graphite or carbon-carbon composite. The segment includes a hollow cylindrical sleeve which has an opening for receiving neutron-absorbing material in the form of pellets or compacted rings. The sleeve has a threaded sleeve bore and outer threaded surface. A cylindrical support post has a threaded shaft at one end which is threadably engaged with the sleeve bore to rigidly couple the support post to the sleeve. The other end of the post is formed with a ball portion. A hollow cylindrical collar has an inner threaded surface engageable with the outer threaded surface of the sleeve to rigidly couple the collar to the sleeve. the collar also has a socket portion which cooperates with the ball portion to flexibly connect segments together to form a ball and socket-type joint. In another embodiment, the segment comprises a support member which has a threaded shaft portion and a ball surface portion. The threaded shaft portion is engageable with an inner threaded surface of a ring for rigidly coupling the support member to the ring. The ring in turn has an outer surface at one end which is threadably engageably with a hollow cylindrical sleeve. The other end of the sleeve is formed with a socket portion for engagement with a ball portion of the support member. In yet another embodiment, a secondary rod is slidably inserted in a hollow channel through the center of the segment to provide additional strength. A method for controlling a nuclear reactor utilizing the control rod assembly is also included.

The effect of polyether functional polydimethylsiloxane on surface and thermal properties of waterborne polyurethane

NASA Astrophysics Data System (ADS)

Zheng, Guikai; Lu, Ming; Rui, Xiaoping

2017-03-01

Waterborne polyurethanes (WPU) modified with polyether functional polydimethylsiloxane (PDMS) were synthesized by pre-polymerization method using isophorone diisocyanate (IPDI) and 1,4-butanediol (BDO) as hard segments and polybutylene adipate glycol (PBA) and polyether functional PDMS as soft segments. The effect of polyether functional PDMS on phase separation, thermal properties, surface properties including surface composition, morphology and wettability were investigated by FTIR, contact angle measurements, ARXPS, SEM-EDS, AFM, TG and DSC. The results showed that the compatibility between urethane hard segment and PDMS modified with polyether was good, and there was no distinct phase separation in both bulk and surface of WPU films. The degradation temperature and low temperature flexibility increased with increasing amounts of polyether functional PDMS. The enrichment of polyether functional PDMS with low surface energy on the surface imparted excellent hydrophobicity to WPU films.

Surface Deformation During a Magmatic Intrusion: the Example of the Dabba'hu Rift Crisis of 2005-2006 (Afar, Ethiopia)

NASA Astrophysics Data System (ADS)

Grandin, R.; Socquet, A.; Binet, R.; Jacques, E.; Klinger, Y.; de Chabalier, J.; King, G.; Tait, S.; Tapponnier, P.; Delorme, A.; Elissalde, C.

2007-12-01

In September 2005, a magmato-tectonic episode initiated in Western Afar (Ethiopia) when a swarm of moderate magnitude earthquakes (M<5.6) was recorded for several days. A small eruption also occurred on the eastern flank of Dabba'hu, a large silicic volcano located at the northern extremity of the Dabba'hu rift segment. The terrain is exceptionally favorable for InSAR imagery and surface fault mapping, making this event a rare opportunity to study how surface faulting and dike injection were mechanically coupled during the rifting event. Based on the combination of InSAR images shot on both ascending and descending tracks, and the correlation of SAR amplitude images, we deduced the vertical motions inside the rift during the main intrusion event. Together with the correlation of SPOT optical images, the horizontal component of opening can be retrieved. We provide evidence for an average of 6 m of opening across the 40 km northern Dabba'hu segment, during the September crisis. The inner floor of the rift subsided by ~ 2m, while the shoulders were uplifted by ~ 2m. A deficit of opening was observed in the southern segment during the main crisis. However, a second intrusive event occurred in mid-2006, leading to the further opening of this 20 km segment by an additional ~ 2m. A series of interferograms covering the post-crises periods show that significant motion also occurred between the crises and after the second crisis. Using a comparison between pre-crisis aerial photographs and post-crisis high-resolution Quickbird images, combined with SAR coherence images, we are able to map the structures that were reactivated during the crisis, and show extensive evidence of newly exposed fractures in recent basalts. The motion on a large number of en echelon faults and fissures could be observed with much greater detail than during the main rifting event. Using a DEM of the area, generated using SPOT images, the relation between faulting and rift morphology is addressed. Concentric subsidence and/or uplift occurred at various stages of the crisis on distinct volcanic edifices, pointing to a complex scenario for the possible connection between shallow and deep magmatic chambers. The estimated extension rate of 15 mm/year across the plate boundary [Vigny et al., 2006] yields a recurrence time of the order of 500 years for events of this magnitude. Surprisingly, despite the large volume of magma intruded during the September 2005 event (~ 15 km2), no basalt flows were observed.

Comparison of automatic and visual methods used for image segmentation in Endodontics: a microCT study.

PubMed

Queiroz, Polyane Mazucatto; Rovaris, Karla; Santaella, Gustavo Machado; Haiter-Neto, Francisco; Freitas, Deborah Queiroz

2017-01-01

To calculate root canal volume and surface area in microCT images, an image segmentation by selecting threshold values is required, which can be determined by visual or automatic methods. Visual determination is influenced by the operator's visual acuity, while the automatic method is done entirely by computer algorithms. To compare between visual and automatic segmentation, and to determine the influence of the operator's visual acuity on the reproducibility of root canal volume and area measurements. Images from 31 extracted human anterior teeth were scanned with a μCT scanner. Three experienced examiners performed visual image segmentation, and threshold values were recorded. Automatic segmentation was done using the "Automatic Threshold Tool" available in the dedicated software provided by the scanner's manufacturer. Volume and area measurements were performed using the threshold values determined both visually and automatically. The paired Student's t-test showed no significant difference between visual and automatic segmentation methods regarding root canal volume measurements (p=0.93) and root canal surface (p=0.79). Although visual and automatic segmentation methods can be used to determine the threshold and calculate root canal volume and surface, the automatic method may be the most suitable for ensuring the reproducibility of threshold determination.

Defect Detection of Steel Surfaces with Global Adaptive Percentile Thresholding of Gradient Image

NASA Astrophysics Data System (ADS)

Neogi, Nirbhar; Mohanta, Dusmanta K.; Dutta, Pranab K.

2017-12-01

Steel strips are used extensively for white goods, auto bodies and other purposes where surface defects are not acceptable. On-line surface inspection systems can effectively detect and classify defects and help in taking corrective actions. For detection of defects use of gradients is very popular in highlighting and subsequently segmenting areas of interest in a surface inspection system. Most of the time, segmentation by a fixed value threshold leads to unsatisfactory results. As defects can be both very small and large in size, segmentation of a gradient image based on percentile thresholding can lead to inadequate or excessive segmentation of defective regions. A global adaptive percentile thresholding of gradient image has been formulated for blister defect and water-deposit (a pseudo defect) in steel strips. The developed method adaptively changes the percentile value used for thresholding depending on the number of pixels above some specific values of gray level of the gradient image. The method is able to segment defective regions selectively preserving the characteristics of defects irrespective of the size of the defects. The developed method performs better than Otsu method of thresholding and an adaptive thresholding method based on local properties.

A semiautomatic segmentation method for prostate in CT images using local texture classification and statistical shape modeling.

PubMed

Shahedi, Maysam; Halicek, Martin; Guo, Rongrong; Zhang, Guoyi; Schuster, David M; Fei, Baowei

2018-06-01

Prostate segmentation in computed tomography (CT) images is useful for treatment planning and procedure guidance such as external beam radiotherapy and brachytherapy. However, because of the low, soft tissue contrast of CT images, manual segmentation of the prostate is a time-consuming task with high interobserver variation. In this study, we proposed a semiautomated, three-dimensional (3D) segmentation for prostate CT images using shape and texture analysis and we evaluated the method against manual reference segmentations. The prostate gland usually has a globular shape with a smoothly curved surface, and its shape could be accurately modeled or reconstructed having a limited number of well-distributed surface points. In a training dataset, using the prostate gland centroid point as the origin of a coordination system, we defined an intersubject correspondence between the prostate surface points based on the spherical coordinates. We applied this correspondence to generate a point distribution model for prostate shape using principal component analysis and to study the local texture difference between prostate and nonprostate tissue close to the different prostate surface subregions. We used the learned shape and texture characteristics of the prostate in CT images and then combined them with user inputs to segment a new image. We trained our segmentation algorithm using 23 CT images and tested the algorithm on two sets of 10 nonbrachytherapy and 37 postlow dose rate brachytherapy CT images. We used a set of error metrics to evaluate the segmentation results using two experts' manual reference segmentations. For both nonbrachytherapy and post-brachytherapy image sets, the average measured Dice similarity coefficient (DSC) was 88% and the average mean absolute distance (MAD) was 1.9 mm. The average measured differences between the two experts on both datasets were 92% (DSC) and 1.1 mm (MAD). The proposed, semiautomatic segmentation algorithm showed a fast, robust, and accurate performance for 3D prostate segmentation of CT images, specifically when no previous, intrapatient information, that is, previously segmented images, was available. The accuracy of the algorithm is comparable to the best performance results reported in the literature and approaches the interexpert variability observed in manual segmentation. © 2018 American Association of Physicists in Medicine.

Shape-Driven 3D Segmentation Using Spherical Wavelets

PubMed Central

Nain, Delphine; Haker, Steven; Bobick, Aaron; Tannenbaum, Allen

2013-01-01

This paper presents a novel active surface segmentation algorithm using a multiscale shape representation and prior. We define a parametric model of a surface using spherical wavelet functions and learn a prior probability distribution over the wavelet coefficients to model shape variations at different scales and spatial locations in a training set. Based on this representation, we derive a parametric active surface evolution using the multiscale prior coefficients as parameters for our optimization procedure to naturally include the prior in the segmentation framework. Additionally, the optimization method can be applied in a coarse-to-fine manner. We apply our algorithm to the segmentation of brain caudate nucleus, of interest in the study of schizophrenia. Our validation shows our algorithm is computationally efficient and outperforms the Active Shape Model algorithm by capturing finer shape details. PMID:17354875

The Wasatch fault zone, utah—segmentation and history of Holocene earthquakes

NASA Astrophysics Data System (ADS)

Machette, Michael N.; Personius, Stephen F.; Nelson, Alan R.; Schwartz, David P.; Lund, William R.

The Wasatch fault zone (WFZ) forms the eastern boundary of the Basin and Range province and is the longest continuous, active normal fault (343 km) in the United States. It underlies an urban corridor of 1.6 million people (80% of Utah's population) representing the largest earthquake risk in the interior of the western United States. We have used paleoseismological data to identify 10 discrete segments of the WFZ. Five are active, medial segments with Holocene slip rates of 1-2 mm a -1, recurrence intervals of 2000-4000 years and average lengths of about 50 km. Five are less active, distal segments with mostly pre-Holocene surface ruptures, late Quaternary slip rates of <0.5 mm a -1 recurrence intervals of ≥10,000 years and average lengths of about 20 km. Surface-faulting events on each of the medial segments of the WFZ formed 2-4-m-high scarps repeatedly during the Holocene; latest Pleistocene (14-15 ka) deposits commonly have scarps as much as 15-20 m in height. Segments identified from paleoseismological studies of other major late Quaternary normal faults in the northern Basin and Range province are 20-25 km long, or about half of that proposed for the medial segments of the WFZ. Paleoseismological records for the past 6000 years indicate that a major surface-rupturing earthquake has occurred along one of the medial segments about every 395 ± 60 years. However, between about 400 and 1500 years ago, the WFZ experienced six major surface-rupturing events, an average of one event every 220 years, or about twice as often as expected from the 6000-year record. This pattern of temporal clustering is similar to that of the central Nevada—eastern California Seismic Belt in the western part of the Basin and Range province, where 11 earthquakes of M > 6.5 have occurred since 1860. Although the time scale of the clustering is different—130 years vs 1100 years—we consider the central Nevada—eastern California Seismic Belt to be a historic analog for movement on the WFZ during the past 1500 years. We have found no evidence that surface-rupturing events occurred on the WFZ during the past 400 years, a time period which is twice the average intracluster recurrence interval and equal to the average Holocene recurrence interval. In particular, the Brigham City segment (the northernmost medial segment) has not ruptured in the past 3600 years—a period that is about three times longer than this segment's average recurrence interval during the early and middle Holocene. Although the WFZ's seismological record is one of relative quiescence, a comparison with other historic surface-rupturing earthquakes in the region suggests that earthquakes having moment magnitudes of 7.1-7.4 (or surface-wave magnitudes of 7.5-7.7)—each associated with tens of kilometers of surface rupture and several meters of normal dip slip—have occurred about every four centuries during the Holocene and should be expected in the future.

Wasatch fault zone, Utah - segmentation and history of Holocene earthquakes

USGS Publications Warehouse

Machette, Michael N.; Personius, Stephen F.; Nelson, Alan R.; Schwartz, David P.; Lund, William R.

1991-01-01

The Wasatch fault zone (WFZ) forms the eastern boundary of the Basin and Range province and is the longest continuous, active normal fault (343 km) in the United States. It underlies an urban corridor of 1.6 million people (80% of Utah's population) representing the largest earthquake risk in the interior of the western United States. The authors have used paleoseismological data to identify 10 discrete segments of the WFZ. Five are active, medial segments with Holocene slip rates of 1-2 mm a-1, recurrence intervals of 2000-4000 years and average lengths of about 50 km. Five are less active, distal segments with mostly pre-Holocene surface ruptures, late Quaternary slip rates of <0.5 mm a-1, recurrence intervals of ???10,000 years and average lengths of about 20 km. Surface-faulting events on each of the medial segments of the WFZ formed 2-4-m-high scarps repeatedly during the Holocene. Paleoseismological records for the past 6000 years indicate that a major surface-rupturing earthquake has occurred along one of the medial segments about every 395 ?? 60 years. However, between about 400 and 1500 years ago, the WFZ experienced six major surface-rupturing events, an average of one event every 220 years, or about twice as often as expected from the 6000-year record. Evidence has been found that surface-rupturing events occurred on the WFZ during the past 400 years, a time period which is twice the average intracluster recurrence interval and equal to the average Holocene recurrence interval.

Segmentation of facial bone surfaces by patch growing from cone beam CT volumes

PubMed Central

Lilja, Mikko; Kalke, Martti

2016-01-01

Objectives: The motivation behind this work was to design an automatic algorithm capable of segmenting the exterior of the dental and facial bones including the mandible, teeth, maxilla and zygomatic bone with an open surface (a surface with a boundary) from CBCT images for the anatomy-based reconstruction of radiographs. Such an algorithm would provide speed, consistency and improved image quality for clinical workflows, for example, in planning of implants. Methods: We used CBCT images from two studies: first to develop (n = 19) and then to test (n = 30) a segmentation pipeline. The pipeline operates by parameterizing the topology and shape of the target, searching for potential points on the facial bone–soft tissue edge, reconstructing a triangular mesh by growing patches on from the edge points with good contrast and regularizing the result with a surface polynomial. This process is repeated for convergence. Results: The output of the algorithm was benchmarked against a hand-drawn reference and reached a 0.50 ± 1.0-mm average and 1.1-mm root mean squares error in Euclidean distance from the reference to our automatically segmented surface. These results were achieved with images affected by inhomogeneity, noise and metal artefacts that are typical for dental CBCT. Conclusions: Previously, this level of accuracy and precision in dental CBCT has been reported in segmenting only the mandible, a much easier target. The segmentation results were consistent throughout the data set and the pipeline was found fast enough (<1-min average computation time) to be considered for clinical use. PMID:27482878

Tool Measures Depths of Defects on a Case Tang Joint

NASA Technical Reports Server (NTRS)

Ream, M. Bryan; Montgomery, Ronald B.; Mecham, Brent A.; Keirstead, Bums W.

2005-01-01

A special-purpose tool has been developed for measuring the depths of defects on an O-ring seal surface. The surface lies in a specially shaped ringlike fitting, called a capture feature tang, located on an end of a cylindrical segment of a case that contains a solid-fuel booster rocket motor for launching a space shuttle. The capture feature tang is a part of a tang-and-clevis, O-ring joint between the case segment and a similar, adjacent cylindrical case segment. When the segments are joined, the tang makes an interference fit with the clevis and squeezes the O-ring at the side of the gap.

Strain corrosion cracking in rpm sewer piping

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopkins, S.W.; Wachob, H.F.; Duffner, D.H.

1993-12-31

Long term, aggressive environmental exposure can result in localized failure of large diameter, glass reinforced plastic mortar (RPM) piping. In order to evaluate the performance of the liner and glass reinforced matrix polyester resin, accelerated strain corrosion tests were performed on samples of RPM piping that had already experienced almost 15 years of service. To assess the sensitivity of RPM pipe to acidic environments and to correlate the fractography of the laboratory produced failures with the excavated crack, short segments of 8-inch and 48-inch diameter piping were statically loaded to produce various known surface strains. After preloading the specimens tomore » fixed strain levels, these samples were then exposed to sulfuric acid solutions having pH values of 2.7 and 4.7 and monitored as a function of time until failure. The resulting lifetimes were related to initial surface strains and showed a decreasing logarithmic relationship. Fractographic examination of the excavated crack revealed the typical strain corrosion fractography of glass fibers after almost a 1000 hour exposure at 1.3 % strain; similar fractographic observations were obtained from failed laboratory samples. At shorter times, failure appeared to be overload in nature and exhibited little, if any, timedependent fracture features. Fractographic examination of the excavated crack strongly indicated that the crack had been present for a significant time. The extremely aggressive environment had totally dissolved the exposed glass reinforcement. Based on the laboratory strain corrosion performance, the nature of the contained cracking, and fractography of the failed surface, cracking of the excavated RPM pipe was believed to be the result of an early overload failure that subsequently propagated slowly via strain corrosion in an extremely aggressive environment.« less

Investigation of Primary Mirror Segment's Residual Errors for the Thirty Meter Telescope

NASA Technical Reports Server (NTRS)

Seo, Byoung-Joon; Nissly, Carl; Angeli, George; MacMynowski, Doug; Sigrist, Norbert; Troy, Mitchell; Williams, Eric

2009-01-01

The primary mirror segment aberrations after shape corrections with warping harness have been identified as the single largest error term in the Thirty Meter Telescope (TMT) image quality error budget. In order to better understand the likely errors and how they will impact the telescope performance we have performed detailed simulations. We first generated unwarped primary mirror segment surface shapes that met TMT specifications. Then we used the predicted warping harness influence functions and a Shack-Hartmann wavefront sensor model to determine estimates for the 492 corrected segment surfaces that make up the TMT primary mirror. Surface and control parameters, as well as the number of subapertures were varied to explore the parameter space. The corrected segment shapes were then passed to an optical TMT model built using the Jet Propulsion Laboratory (JPL) developed Modeling and Analysis for Controlled Optical Systems (MACOS) ray-trace simulator. The generated exit pupil wavefront error maps provided RMS wavefront error and image-plane characteristics like the Normalized Point Source Sensitivity (PSSN). The results have been used to optimize the segment shape correction and wavefront sensor designs as well as provide input to the TMT systems engineering error budgets.

System and method for crystalline sheet growth using a cold block and gas jet

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kellerman, Peter L.; Mackintosh, Brian; Carlson, Frederick M.

A crystallizer for growing a crystalline sheet from a melt may include a cold block having a cold block surface that faces an exposed surface of the melt, the cold block configured to generate a cold block temperature at the cold block surface that is lower than a melt temperature of the melt at the exposed surface. The system may also include a nozzle disposed within the cold block and configured to deliver a gas jet to the exposed surface, wherein the gas jet and the cold block are interoperative to generate a process zone that removes heat from themore » exposed surface at a first heat removal rate that is greater than a second heat removal rate from the exposed surface in outer regions outside of the process zone.« less

Road surface erosion on the Jackson Demonstration State Forest: results of a pilot study

Treesearch

Brian Barrett; Rosemary Kosaka; David. Tomberlin

2012-01-01

This paper presents results of a 3 year pilot study of surface erosion on forest roads in the Jackson Demonstration State Forest in California’s coastal redwood region. Ten road segments representing a range of surface, grade, and ditch conditions were selected for the study. At each segment, settling basins with tipping buckets were installed to measure...

Improved Oxidation Life of Segmented Plasma Sprayed 8YSZ Thermal Barrier Coatings

NASA Astrophysics Data System (ADS)

Smialek, James L.

2004-03-01

Unconventional plasma sprayed thermal barrier coating (TBC) systems were produced and evaluated by interrupted or cyclic furnace oxidation life testing. First, approximately 250 µm thick 8YSZ coatings were directly sprayed onto grit blasted surfaces of PWA 1484, without a bond coat, to take advantage of the excellent oxidation resistance of this superalloy. For nominal sulfur (S) contents of 1 ppmw, total coating separation took place at relatively short times (200 h at 1100°C). Reductions in the S content, by melt desulfurization commercially (0.3 ppmw) or by hydrogen (H2) annealing in the laboratory (0.01 ppmw), improved scale adhesion and extended life appreciably, by factors of 5-10. However, edge-initiated failure persisted, producing massive delamination as one sheet of coating. Secondly, surfaces of melt desulfurized PWA 1484 were machined with a grid of grooves or ribs (˜250 µm wide and high), resulting in a segmented TBC surface macrostructure, for the purpose of subverting this failure mechanism. In this case, failure occurred only as independent, single-segment events. For grooved samples, 1100 °C segment life was extended to ˜1000h for 5 mm wide segments, with no failure observed out to 2000 h for segments ≤2.5 mm wide. Ribbed samples were even more durable, and segments ≤6 mm remained intact for 2000 h. Larger segments failed by buckling at times inversely related to the segment width and decreased by oxidation effects at higher temperatures. This critical buckling size was consistent with that predicted for elastic buckling of a TBC plate subject to thermal expansion mismatch stresses. Thus, low S substrates demonstrate appreciable coating lives without a bond coat, while rib segmenting extends life considerably.

Multiparametric AFM reveals turgor-responsive net-like peptidoglycan architecture in live streptococci

NASA Astrophysics Data System (ADS)

Saar Dover, Ron; Bitler, Arkady; Shimoni, Eyal; Trieu-Cuot, Patrick; Shai, Yechiel

2015-05-01

Cell-wall peptidoglycan (PG) of Gram-positive bacteria is a strong and elastic multi-layer designed to resist turgor pressure and determine the cell shape and growth. Despite its crucial role, its architecture remains largely unknown. Here using high-resolution multiparametric atomic force microscopy (AFM), we studied how the structure and elasticity of PG change when subjected to increasing turgor pressure in live Group B Streptococcus. We show a new net-like arrangement of PG, which stretches and stiffens following osmotic challenge. The same structure also exists in isogenic mutants lacking surface appendages. Cell aging does not alter the elasticity of the cell wall, yet destroys the net architecture and exposes single segmented strands with the same circumferential orientation as predicted for intact glycans. Together, we show a new functional PG architecture in live Gram-positive bacteria.

Lamp bulb with integral reflector

DOEpatents

Levin, Izrail; Shanks, Bruce; Sumner, Thomas L.

2001-01-01

An improved electrodeless discharge lamp bulb includes an integral ceramic reflector as a portion of the bulb envelope. The bulb envelope further includes two pieces, a reflector portion or segment is cast quartz ceramic and a light transmissive portion is a clear fused silica. In one embodiment, the cast quartz ceramic segment includes heat sink fins or stubs providing an increased outside surface area to dissipate internal heat. In another embodiment, the quartz ceramic segment includes an outside surface fused to eliminate gas permeation by polishing.

Dual-Mode Adhesive Pad

NASA Technical Reports Server (NTRS)

Hartz, Leslie

1994-01-01

Tool helps worker grip and move along large, smooth structure with no handgrips or footholds. Adheres to surface but easily released by actuating simple mechanism. Includes handle and segmented contact-adhesive pad. Bulk of pad made of soft plastic foam conforming to surface of structure. Each segment reinforced with rib. In sticking mode, ribs braced by side catches. In peeling mode, side catches retracted, and segmented adhesive pad loses its stiffness. Modified versions useful in inspecting hulls of ships and scaling walls in rescue operations.

Graph-based surface reconstruction from stereo pairs using image segmentation

NASA Astrophysics Data System (ADS)

Bleyer, Michael; Gelautz, Margrit

2005-01-01

This paper describes a novel stereo matching algorithm for epipolar rectified images. The method applies colour segmentation on the reference image. The use of segmentation makes the algorithm capable of handling large untextured regions, estimating precise depth boundaries and propagating disparity information to occluded regions, which are challenging tasks for conventional stereo methods. We model disparity inside a segment by a planar equation. Initial disparity segments are clustered to form a set of disparity layers, which are planar surfaces that are likely to occur in the scene. Assignments of segments to disparity layers are then derived by minimization of a global cost function via a robust optimization technique that employs graph cuts. The cost function is defined on the pixel level, as well as on the segment level. While the pixel level measures the data similarity based on the current disparity map and detects occlusions symmetrically in both views, the segment level propagates the segmentation information and incorporates a smoothness term. New planar models are then generated based on the disparity layers' spatial extents. Results obtained for benchmark and self-recorded image pairs indicate that the proposed method is able to compete with the best-performing state-of-the-art algorithms.

Assessment of multiresolution segmentation for delimiting drumlins in digital elevation models.

PubMed

Eisank, Clemens; Smith, Mike; Hillier, John

2014-06-01

Mapping or "delimiting" landforms is one of geomorphology's primary tools. Computer-based techniques such as land-surface segmentation allow the emulation of the process of manual landform delineation. Land-surface segmentation exhaustively subdivides a digital elevation model (DEM) into morphometrically-homogeneous irregularly-shaped regions, called terrain segments. Terrain segments can be created from various land-surface parameters (LSP) at multiple scales, and may therefore potentially correspond to the spatial extents of landforms such as drumlins. However, this depends on the segmentation algorithm, the parameterization, and the LSPs. In the present study we assess the widely used multiresolution segmentation (MRS) algorithm for its potential in providing terrain segments which delimit drumlins. Supervised testing was based on five 5-m DEMs that represented a set of 173 synthetic drumlins at random but representative positions in the same landscape. Five LSPs were tested, and four variants were computed for each LSP to assess the impact of median filtering of DEMs, and logarithmic transformation of LSPs. The testing scheme (1) employs MRS to partition each LSP exhaustively into 200 coarser scales of terrain segments by increasing the scale parameter ( SP ), (2) identifies the spatially best matching terrain segment for each reference drumlin, and (3) computes four segmentation accuracy metrics for quantifying the overall spatial match between drumlin segments and reference drumlins. Results of 100 tests showed that MRS tends to perform best on LSPs that are regionally derived from filtered DEMs, and then log-transformed. MRS delineated 97% of the detected drumlins at SP values between 1 and 50. Drumlin delimitation rates with values up to 50% are in line with the success of manual interpretations. Synthetic DEMs are well-suited for assessing landform quantification methods such as MRS, since subjectivity in the reference data is avoided which increases the reliability, validity and applicability of results.

Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure.

PubMed

Dongaonkar, R M; Nguyen, T L; Quick, C M; Hardy, J; Laine, G A; Wilson, E; Stewart, R H

2013-07-15

In vitro studies have revealed that acute increases in transmural pressure increase lymphatic vessel contractile function. However, adaptive responses to prolonged changes in transmural pressure in vivo have not been reported. Therefore, we developed a novel bovine mesenteric lymphatic partial constriction model to test the hypothesis that lymphatic vessels exposed to higher transmural pressures adapt functionally to become stronger pumps than vessels exposed to lower transmural pressures. Postnodal mesenteric lymphatic vessels were partially constricted for 3 days. On postoperative day 3, constricted vessels were isolated, and divided into upstream (UP) and downstream (DN) segment groups, and instrumented in an isolated bath. Although there were no differences between the passive diameters of the two groups, both diastolic diameter and systolic diameter were significantly larger in the UP group than in the DN group. The pump index of the UP group was also higher than that in the DN group. In conclusion, this is the first work to report how lymphatic vessels adapt to prolonged changes in transmural pressure in vivo. Our results suggest that vessel segments upstream of the constriction adapt to become both better fluid conduits and lymphatic pumps than downstream segments.

Conformational transition free energy profiles of an adsorbed, lattice model protein by multicanonical Monte Carlo simulation

NASA Astrophysics Data System (ADS)

Castells, Victoria; Van Tassel, Paul R.

2005-02-01

Proteins often undergo changes in internal conformation upon interacting with a surface. We investigate the thermodynamics of surface induced conformational change in a lattice model protein using a multicanonical Monte Carlo method. The protein is a linear heteropolymer of 27 segments (of types A and B) confined to a cubic lattice. The segmental order and nearest neighbor contact energies are chosen to yield, in the absence of an adsorbing surface, a unique 3×3×3 folded structure. The surface is a plane of sites interacting either equally with A and B segments (equal affinity surface) or more strongly with the A segments (A affinity surface). We use a multicanonical Monte Carlo algorithm, with configuration bias and jump walking moves, featuring an iteratively updated sampling function that converges to the reciprocal of the density of states 1/Ω(E), E being the potential energy. We find inflection points in the configurational entropy, S(E)=klnΩ(E), for all but a strongly adsorbing equal affinity surface, indicating the presence of free energy barriers to transition. When protein-surface interactions are weak, the free energy profiles F(E)=E-TS(E) qualitatively resemble those of a protein in the absence of a surface: a free energy barrier separates a folded, lowest energy state from globular, higher energy states. The surface acts in this case to stabilize the globular states relative to the folded state. When the protein surface interactions are stronger, the situation differs markedly: the folded state no longer occurs at the lowest energy and free energy barriers may be absent altogether.

Molecular Evolution and Mosaicism of Leptospiral Outer Membrane Proteins Involves Horizontal DNA Transfer

PubMed Central

Haake, David A.; Suchard, Marc A.; Kelley, Melissa M.; Dundoo, Manjula; Alt, David P.; Zuerner, Richard L.

2004-01-01

Leptospires belong to a genus of parasitic bacterial spirochetes that have adapted to a broad range of mammalian hosts. Mechanisms of leptospiral molecular evolution were explored by sequence analysis of four genes shared by 38 strains belonging to the core group of pathogenic Leptospira species: L. interrogans, L. kirschneri, L. noguchii, L. borgpetersenii, L. santarosai, and L. weilii. The 16S rRNA and lipL32 genes were highly conserved, and the lipL41 and ompL1 genes were significantly more variable. Synonymous substitutions are distributed throughout the ompL1 gene, whereas nonsynonymous substitutions are clustered in four variable regions encoding surface loops. While phylogenetic trees for the 16S, lipL32, and lipL41 genes were relatively stable, 8 of 38 (20%) ompL1 sequences had mosaic compositions consistent with horizontal transfer of DNA between related bacterial species. A novel Bayesian multiple change point model was used to identify the most likely sites of recombination and to determine the phylogenetic relatedness of the segments of the mosaic ompL1 genes. Segments of the mosaic ompL1 genes encoding two of the surface-exposed loops were likely acquired by horizontal transfer from a peregrine allele of unknown ancestry. Identification of the most likely sites of recombination with the Bayesian multiple change point model, an approach which has not previously been applied to prokaryotic gene sequence analysis, serves as a model for future studies of recombination in molecular evolution of genes. PMID:15090524

Effects of cyclic flexure on endothelial permeability and apoptosis in arterial segments perfused ex vivo.

PubMed

Van Epps, J Scott; Chew, Douglas W; Vorp, David A

2009-10-01

Certain arteries (e.g., coronary, femoral, etc.) are exposed to cyclic flexure due to their tethering to surrounding tissue beds. It is believed that such stimuli result in a spatially variable biomechanical stress distribution, which has been implicated as a key modulator of remodeling associated with atherosclerotic lesion localization. In this study we utilized a combined ex vivo experimental/computational methodology to address the hypothesis that local variations in shear and mural stress associated with cyclic flexure influence the distribution of early markers of atherogenesis. Bilateral porcine femoral arteries were surgically harvested and perfused ex vivo under pulsatile arterial conditions. One of the paired vessels was exposed to cyclic flexure (0-0.7 cm(-1)) at 1 Hz for 12 h. During the last hour, the perfusate was supplemented with Evan's blue dye-labeled albumin. A custom tissue processing protocol was used to determine the spatial distribution of endothelial permeability, apoptosis, and proliferation. Finite element and computational fluid dynamics techniques were used to determine the mural and shear stress distributions, respectively, for each perfused segment. Biological data obtained experimentally and mechanical stress data estimated computationally were combined in an experiment-specific manner using multiple linear regression analyses. Arterial segments exposed to cyclic flexure had significant increases in intimal and medial apoptosis (3.42+/-1.02 fold, p=0.029) with concomitant increases in permeability (1.14+/-0.04 fold, p=0.026). Regression analyses revealed specific mural stress measures including circumferential stress at systole, and longitudinal pulse stress were quantitatively correlated with the distribution of permeability and apoptosis. The results demonstrated that local variation in mechanical stress in arterial segments subjected to cyclic flexure indeed influence the extent and spatial distribution of the early atherogenic markers. In addition, the importance of including mural stresses in the investigation of vascular mechanopathobiology was highlighted. Specific example results were used to describe a potential mechanism by which systemic risk factors can lead to a heterogeneous disease.

Segmented Mirror Image Degradation Due to Surface Dust, Alignment and Figure

NASA Technical Reports Server (NTRS)

Schreur, Julian J.

1999-01-01

In 1996 an algorithm was developed to include the effects of surface roughness in the calculation of the point spread function of a telescope mirror. This algorithm has been extended to include the effects of alignment errors and figure errors for the individual elements, and an overall contamination by surface dust. The final algorithm builds an array for a guard-banded pupil function of a mirror that may or may not have a central hole, a central reflecting segment, or an outer ring of segments. The central hole, central reflecting segment, and outer ring may be circular or polygonal, and the outer segments may have trimmed comers. The modeled point spread functions show that x-tilt and y-tilt, or the corresponding R-tilt and theta-tilt for a segment in an outer ring, is readily apparent for maximum wavefront errors of 0.1 lambda. A similar sized piston error is also apparent, but integral wavelength piston errors are not. Severe piston error introduces a focus error of the opposite sign, so piston could be adjusted to compensate for segments with varying focal lengths. Dust affects the image principally by decreasing the Strehl ratio, or peak intensity of the image. For an eight-meter telescope a 25% coverage by dust produced a scattered light intensity of 10(exp -9) of the peak intensity, a level well below detectability.

Improve accuracy for automatic acetabulum segmentation in CT images.

PubMed

Liu, Hao; Zhao, Jianning; Dai, Ning; Qian, Hongbo; Tang, Yuehong

2014-01-01

Separation of the femur head and acetabulum is one of main difficulties in the diseased hip joint due to deformed shapes and extreme narrowness of the joint space. To improve the segmentation accuracy is the key point of existing automatic or semi-automatic segmentation methods. In this paper, we propose a new method to improve the accuracy of the segmented acetabulum using surface fitting techniques, which essentially consists of three parts: (1) design a surface iterative process to obtain an optimization surface; (2) change the ellipsoid fitting to two-phase quadric surface fitting; (3) bring in a normal matching method and an optimization region method to capture edge points for the fitting quadric surface. Furthermore, this paper cited vivo CT data sets of 40 actual patients (with 79 hip joints). Test results for these clinical cases show that: (1) the average error of the quadric surface fitting method is 2.3 (mm); (2) the accuracy ratio of automatically recognized contours is larger than 89.4%; (3) the error ratio of section contours is less than 10% for acetabulums without severe malformation and less than 30% for acetabulums with severe malformation. Compared with similar methods, the accuracy of our method, which is applied in a software system, is significantly enhanced.

Stress Analysis of Bolted, Segmented Cylindrical Shells Exhibiting Flange Mating-Surface Waviness

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Phillips, Dawn R.; Raju, Ivatury S.

2009-01-01

Bolted, segmented cylindrical shells are a common structural component in many engineering systems especially for aerospace launch vehicles. Segmented shells are often needed due to limitations of manufacturing capabilities or transportation issues related to very long, large-diameter cylindrical shells. These cylindrical shells typically have a flange or ring welded to opposite ends so that shell segments can be mated together and bolted to form a larger structural system. As the diameter of these shells increases, maintaining strict fabrication tolerances for the flanges to be flat and parallel on a welded structure is an extreme challenge. Local fit-up stresses develop in the structure due to flange mating-surface mismatch (flange waviness). These local stresses need to be considered when predicting a critical initial flaw size. Flange waviness is one contributor to the fit-up stress state. The present paper describes the modeling and analysis effort to simulate fit-up stresses due to flange waviness in a typical bolted, segmented cylindrical shell. Results from parametric studies are presented for various flange mating-surface waviness distributions and amplitudes.

Cryogenic rf test of the first SRF cavity etched in an rf Ar/Cl2 plasma

NASA Astrophysics Data System (ADS)

Upadhyay, J.; Palczewski, A.; Popović, S.; Valente-Feliciano, A.-M.; Im, Do; Phillips, H. L.; Vušković, L.

2017-12-01

An apparatus and a method for etching of the inner surfaces of superconducting radio frequency (SRF) accelerator cavities are described. The apparatus is based on the reactive ion etching performed in an Ar/Cl2 cylindrical capacitive discharge with reversed asymmetry. To test the effect of the plasma etching on the cavity rf performance, a 1497 MHz single cell SRF cavity was used. The single cell cavity was mechanically polished and buffer chemically etched and then rf tested at cryogenic temperatures to provide a baseline characterization. The cavity's inner wall was then exposed to the capacitive discharge in a mixture of Argon and Chlorine. The inner wall acted as the grounded electrode, while kept at elevated temperature. The processing was accomplished by axially moving the dc-biased, corrugated inner electrode and the gas flow inlet in a step-wise manner to establish a sequence of longitudinally segmented discharges. The cavity was then tested in a standard vertical test stand at cryogenic temperatures. The rf tests and surface condition results, including the electron field emission elimination, are presented.

Capturing the sensitivity of land-use regression models to short-term mobile monitoring campaigns using air pollution micro-sensors.

PubMed

Minet, L; Gehr, R; Hatzopoulou, M

2017-11-01

The development of reliable measures of exposure to traffic-related air pollution is crucial for the evaluation of the health effects of transportation. Land-use regression (LUR) techniques have been widely used for the development of exposure surfaces, however these surfaces are often highly sensitive to the data collected. With the rise of inexpensive air pollution sensors paired with GPS devices, we witness the emergence of mobile data collection protocols. For the same urban area, can we achieve a 'universal' model irrespective of the number of locations and sampling visits? Can we trade the temporal representation of fixed-point sampling for a larger spatial extent afforded by mobile monitoring? This study highlights the challenges of short-term mobile sampling campaigns in terms of the resulting exposure surfaces. A mobile monitoring campaign was conducted in 2015 in Montreal; nitrogen dioxide (NO 2 ) levels at 1395 road segments were measured under repeated visits. We developed LUR models based on sub-segments, categorized in terms of the number of visits per road segment. We observe that LUR models were highly sensitive to the number of road segments and to the number of visits per road segment. The associated exposure surfaces were also highly dissimilar. Copyright © 2017 Elsevier Ltd. All rights reserved.

Optical Design of Segmented Hexagon Array Solar Mirror

NASA Technical Reports Server (NTRS)

Huegele, Vince

2000-01-01

A segmented array of mirrors was designed for a solar concentrator test stand at MSFC for firing solar thermal propulsion engines. The 144 mirrors each have a spherical surface to approximate a parabolic concentrator when combined into the entire 18-foot diameter array. The mirror segments are aluminum hexagons that had the surface diamond turned and quartz coated. The array focuses sunlight reflected from a heliostat to a 4 inch diameter spot containing 10 kw of power at the 15-foot focal point. The derivation of the surface figure for the respective mirror elements is shown. The alignment process of the array is discussed and test results of the system's performance is given.

3D surface voxel tracing corrector for accurate bone segmentation.

PubMed

Guo, Haoyan; Song, Sicong; Wang, Jinke; Guo, Maozu; Cheng, Yuanzhi; Wang, Yadong; Tamura, Shinichi

2018-06-18

For extremely close bones, their boundaries are weak and diffused due to strong interaction between adjacent surfaces. These factors prevent the accurate segmentation of bone structure. To alleviate these difficulties, we propose an automatic method for accurate bone segmentation. The method is based on a consideration of the 3D surface normal direction, which is used to detect the bone boundary in 3D CT images. Our segmentation method is divided into three main stages. Firstly, we consider a surface tracing corrector combined with Gaussian standard deviation [Formula: see text] to improve the estimation of normal direction. Secondly, we determine an optimal value of [Formula: see text] for each surface point during this normal direction correction. Thirdly, we construct the 1D signal and refining the rough boundary along the corrected normal direction. The value of [Formula: see text] is used in the first directional derivative of the Gaussian to refine the location of the edge point along accurate normal direction. Because the normal direction is corrected and the value of [Formula: see text] is optimized, our method is robust to noise images and narrow joint space caused by joint degeneration. We applied our method to 15 wrists and 50 hip joints for evaluation. In the wrist segmentation, Dice overlap coefficient (DOC) of [Formula: see text]% was obtained by our method. In the hip segmentation, fivefold cross-validations were performed for two state-of-the-art methods. Forty hip joints were used for training in two state-of-the-art methods, 10 hip joints were used for testing and performing comparisons. The DOCs of [Formula: see text], [Formula: see text]%, and [Formula: see text]% were achieved by our method for the pelvis, the left femoral head and the right femoral head, respectively. Our method was shown to improve segmentation accuracy for several specific challenging cases. The results demonstrate that our approach achieved a superior accuracy over two state-of-the-art methods.

The Wasatch fault zone, utah-segmentation and history of Holocene earthquakes

USGS Publications Warehouse

Machette, M.N.; Personius, S.F.; Nelson, A.R.; Schwartz, D.P.; Lund, W.R.

1991-01-01

The Wasatch fault zone (WFZ) forms the eastern boundary of the Basin and Range province and is the longest continuous, active normal fault (343 km) in the United States. It underlies an urban corridor of 1.6 million people (80% of Utah's population) representing the largest earthquake risk in the interior of the western United States. We have used paleoseismological data to identify 10 discrete segments of the WFZ. Five are active, medial segments with Holocene slip rates of 1-2 mm a-1, recurrence intervals of 2000-4000 years and average lengths of about 50 km. Five are less active, distal segments with mostly pre-Holocene surface ruptures, late Quaternary slip rates of 6.5 have occurred since 1860. Although the time scale of the clustering is different-130 years vs 1100 years-we consider the central Nevada-eastern California Seismic Belt to be a historic analog for movement on the WFZ during the past 1500 years. We have found no evidence that surface-rupturing events occurred on the WFZ during the past 400 years, a time period which is twice the average intracluster recurrence interval and equal to the average Holocene recurrence interval. In particular, the Brigham City segment (the northernmost medial segment) has not ruptured in the past 3600 years-a period that is about three times longer than this segment's average recurrence interval during the early and middle Holocene. Although the WFZ's seismological record is one of relative quiescence, a comparison with other historic surface-rupturing earthquakes in the region suggests that earthquakes having moment magnitudes of 7.1-7.4 (or surface-wave magnitudes of 7.5-7.7)-each associated with tens of kilometers of surface rupture and several meters of normal dip slip-have occurred about every four centuries during the Holocene and should be expected in the future. ?? 1991.

Structural changes of cytochrome c(552) from Thermus thermophilus adsorbed on anionic and hydrophobic surfaces probed by FTIR and 2D-FTIR spectroscopy.

PubMed

Lecomte, S; Hilleriteau, C; Forgerit, J P; Revault, M; Baron, M H; Hildebrandt, P; Soulimane, T

2001-03-02

The structural changes of cytochrome c(552) bound to anionic and hydrophobic clay surfaces have been investigated by Fourier transform infrared spectroscopy. Binding to the anionic surface of montmorillonite is controlled by electrostatic interactions since addition of electrolyte (0.5 mol L(-1) KCl) causes desorption of more than 2/3 of the protein molecules. Electrostatic binding occurs through the back side of the protein (i.e., remote from the heme site) and is associated only with subtle changes of the secondary structure. In contrast, adsorption to the hydrophobic surface of talc leads to a decrease in alpha-helical structure by ca. 5% and an increase in beta-sheet structure by ca. 6%. These structural changes are attributed to a hydrophobic region on the front surface of cytochrome c(552) close to the partially exposed heme edge. This part on the protein surface is identified as the interaction domain for talc and most likely also serves for binding to the natural reaction partner, a ba(3)-oxidase. Fourier transform infrared spectra of cytochrome c(552) and the clay-cytochrome c(552) complexes have been measured as a function of time following dissolution and suspension in deuterated buffer, respectively. A two-dimensional correlation analysis was applied to these spectra to investigate the dynamics of the structural changes in the protein. For both complexes, adsorption and subsequent unfolding processes in the binding domains are faster than the time resolution of the spectroscopic experiments. Thus, the processes that could be monitored are refolding of peptide segments and side chain rearrangements following the adsorption-induced perturbation of the protein structure and the solvation of the adsorbed protein. In each case, side chain alterations of solvent-exposed tyrosine, aspartate, and glutamate residues were observed. For the cytochrome c(552)-talc complex, these changes are followed by a slow refolding of the peptide chain in the binding domain and, subsequently, a further H/D exchange of amide group protons.

Rearrangement and expression of the human {Psi}C{lambda}6 gene segment results in a surface Ig receptor with a truncated light chain constant region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stiernholm, N.B.J.; Verkoczy, L.K.; Berinstein, N.L.

1995-05-01

The constant region of the human Ig{lambda} locus consists of seven tandemly organized J-C gene segments. Although it has been established that the J-C{lambda}1, J-C{lambda}2, J-C{lambda}3, and J-C{lambda}7 gene segments are functional, and code for the four distinct Ig{lambda} isotypes found in human serum, the J-C{lambda}4, J-C{lambda}5, and J-C{lambda}6 gene segments are generally considered to be pseudogenes. Although one example of a functional J-C{lambda}6 gene segment has been documented, in the majority of cases, J-C{lambda}6 is rendered nonfunctional by virtue of a single duplication of four nucleotides, creating a premature translational arrest. We show here that rearrangements to the J-C{lambda}6more » gene segment do occur, and that such a rearrangement encodes an Ig{lambda} protein that lacks the terminal end of the constant region. We also show that this truncated protein is expressed on the surface with the IgH chain, creating an unusual surface Ig (sIg) receptor (sIg{triangle}CL). Cells that express this receptor on the surface do so at significantly reduced levels compared with clonally related variants, which express sIg receptors with conventional Ig{lambda} L chains. However, the effects of sIg cross-linking on tyrosine phosphorylation and surface expression of the CD25 and CD71 Ags are similar in cells that express conventional sIg receptors and in those that express sIg{triangle}CL receptors, suggesting that the latter could possibly function as an Ag receptor. 35 refs., 7 figs.« less

Bioinformatics analysis for structure and function of CPR of Plasmodium falciparum.

PubMed

Fan, Zhigang; Zhang, Lingmin; Yan, Guogang; Wu, Qiang; Gan, Xiufeng; Zhong, Saifeng; Lin, Guifen

2011-02-01

To analyse the structure and function of NADPH-cytochrome p450 reductase (CYPOR or CPR) from Plasmodium falciparum (Pf), and to predict its' drug target and vaccine target. The structure, function, drug target and vaccine target of CPR from Plasmodium falciparum were analyzed and predicted by bioinformatics methods. PfCPR, which was older CPR, had close relationship with the CPR from other Plasmodium species, but it was distant from its hosts, such as Homo sapiens and Anopheles. PfCPR was located in the cellular nucleus of Plasmodium falciparum. 335aa-352aa and 591aa - 608aa were inserted the interior side of the nuclear membrane, while 151aa-265aa was located in the nucleolus organizer regions. PfCPR had 40 function sites and 44 protein-protein binding sites in amino acid sequence. The teriary structure of 1aa-700aa was forcep-shaped with wings. 15 segments of PfCPR had no homology with Homo sapien CPR and most were exposed on the surface of the protein. These segments had 25 protein-protein binding sites. While 13 other segments all possessed function sites. The evolution or genesis of Plasmodium falciparum is earlier than those of Homo sapiens. PfCPR is a possible resistance site of antimalarial drug and may involve immune evasion, which is associated with parasite of sporozoite in hepatocytes. PfCPR is unsuitable as vaccine target, but it has at least 13 ideal drug targets. Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

Fabrication of complex free-standing nanostructures with concave and convex curvature via the layer-by-layer approach.

PubMed

Raoufi, Mohammad; Schönherr, Holger

2014-02-18

We report on the fabrication of unprecedented free-standing complex polymeric nanoobjects, which possess both concave and convex curvatures, by exploiting the layer-by-layer (LBL) deposition of polyelectrolytes. In a combined top-down/bottom-up replication approach pore diameter-modulated anodic aluminum oxide (AAO) templates, fabricated by temperature modulation hard anodization (TMHA), were replicated with multilayers of poly(styrene sulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) to yield open nanotubes with diameters in the wide and narrow segments of 210 and 150 nm, respectively. To obtain stable pore diameter-modulated nanopores, which possess segment lengths between 1 and 5 μm and 5 and 10 μm in the narrow and wide pore portion, respectively, conventional hard anodization of aluminum was followed by a subsequent temperature-modulated anodization. After removing the backside aluminum electrode, silanizing the aluminum oxide, and passivating the exposed membrane surface with a thin layer of gold, PSS and PAH were deposited alternatingly to yield LBL multilayers. For optimized LBL multilayer thicknesses and compactness, established in separate experiments on silicon substrates and nanoporous AAO with straight pores, free-standing polymeric nanoobjects with concave and convex curvatures, were obtained. These were stable for wall thickness to pore diameter ratios of ≥0.08.

A variational approach to liver segmentation using statistics from multiple sources

NASA Astrophysics Data System (ADS)

Zheng, Shenhai; Fang, Bin; Li, Laquan; Gao, Mingqi; Wang, Yi

2018-01-01

Medical image segmentation plays an important role in digital medical research, and therapy planning and delivery. However, the presence of noise and low contrast renders automatic liver segmentation an extremely challenging task. In this study, we focus on a variational approach to liver segmentation in computed tomography scan volumes in a semiautomatic and slice-by-slice manner. In this method, one slice is selected and its connected component liver region is determined manually to initialize the subsequent automatic segmentation process. From this guiding slice, we execute the proposed method downward to the last one and upward to the first one, respectively. A segmentation energy function is proposed by combining the statistical shape prior, global Gaussian intensity analysis, and enforced local statistical feature under the level set framework. During segmentation, the shape of the liver shape is estimated by minimization of this function. The improved Chan-Vese model is used to refine the shape to capture the long and narrow regions of the liver. The proposed method was verified on two independent public databases, the 3D-IRCADb and the SLIVER07. Among all the tested methods, our method yielded the best volumetric overlap error (VOE) of 6.5 +/- 2.8 % , the best root mean square symmetric surface distance (RMSD) of 2.1 +/- 0.8 mm, the best maximum symmetric surface distance (MSD) of 18.9 +/- 8.3 mm in 3D-IRCADb dataset, and the best average symmetric surface distance (ASD) of 0.8 +/- 0.5 mm, the best RMSD of 1.5 +/- 1.1 mm in SLIVER07 dataset, respectively. The results of the quantitative comparison show that the proposed liver segmentation method achieves competitive segmentation performance with state-of-the-art techniques.

The surface rupture and slip distribution of the 17 August 1999 Izmit earthquake (M 7.4), North Anatolian fault

USGS Publications Warehouse

Barka, A.; Akyuz, H.S.; Altunel, E.; Sunal, G.; Cakir, Z.; Dikbas, A.; Yerli, B.; Armijo, R.; Meyer, B.; De Chabalier, J. B.; Rockwell, Thomas; Dolan, J.R.; Hartleb, R.; Dawson, Tim; Christofferson, S.; Tucker, A.; Fumal, T.; Langridge, Rob; Stenner, H.; Lettis, William; Bachhuber, J.; Page, W.

2002-01-01

The 17 August 1999 İzmit earthquake occurred on the northern strand of the North Anatolian fault zone. The earthquake is associated with a 145-km-long surface rupture that extends from southwest of Düzce in the east to west of Hersek delta in the west. Detailed mapping of the surface rupture shows that it consists of five segments separated by releasing step-overs; herein named the Hersek, Karamürsel-Gölcük, İzmit-Sapanca Lake, Sapanca-Akyazi, and Karadere segments from west to east, respectively. The Hersek segment, which cuts the tip of a large delta plain in the western end of the rupture zone, has an orientation of N80°. The N70°-80°E-trending Karamürsel-Gölcük segment extends along the linear southern coasts of the İzmit Gulf between Karamürsel and Gölcük and produced the 470-cm maximum displacement in Gölcük. The northwest-southeast-striking Gölcük normal fault between the Karamürsel-Gölcük and İzmit-Sapanca segments has 2.3-m maximum vertical displacement. The maximum dextral offset along the İzmit-Sapanca Lake segment was measured to be about 3.5 m, and its trend varies between N80°E and east-west. The Sapanca-Akyazi segment trends N75°-85°W and expresses a maximum displacement of 5.2 m. The Karadere segment trends N65°E and produced up to 1.5-m maximum displacement. The Karadere and Sapanca-Akyazi segments form fan-shape or splaying ruptures near their eastern ends where the displacement also diminished.

Bayesian segmentation of atrium wall using globally-optimal graph cuts on 3D meshes.

PubMed

Veni, Gopalkrishna; Fu, Zhisong; Awate, Suyash P; Whitaker, Ross T

2013-01-01

Efficient segmentation of the left atrium (LA) wall from delayed enhancement MRI is challenging due to inconsistent contrast, combined with noise, and high variation in atrial shape and size. We present a surface-detection method that is capable of extracting the atrial wall by computing an optimal a-posteriori estimate. This estimation is done on a set of nested meshes, constructed from an ensemble of segmented training images, and graph cuts on an associated multi-column, proper-ordered graph. The graph/mesh is a part of a template/model that has an associated set of learned intensity features. When this mesh is overlaid onto a test image, it produces a set of costs which lead to an optimal segmentation. The 3D mesh has an associated weighted, directed multi-column graph with edges that encode smoothness and inter-surface penalties. Unlike previous graph-cut methods that impose hard constraints on the surface properties, the proposed method follows from a Bayesian formulation resulting in soft penalties on spatial variation of the cuts through the mesh. The novelty of this method also lies in the construction of proper-ordered graphs on complex shapes for choosing among distinct classes of base shapes for automatic LA segmentation. We evaluate the proposed segmentation framework on simulated and clinical cardiac MRI.

Tumor Burden Analysis on Computed Tomography by Automated Liver and Tumor Segmentation

PubMed Central

Linguraru, Marius George; Richbourg, William J.; Liu, Jianfei; Watt, Jeremy M.; Pamulapati, Vivek; Wang, Shijun; Summers, Ronald M.

2013-01-01

The paper presents the automated computation of hepatic tumor burden from abdominal CT images of diseased populations with images with inconsistent enhancement. The automated segmentation of livers is addressed first. A novel three-dimensional (3D) affine invariant shape parameterization is employed to compare local shape across organs. By generating a regular sampling of the organ's surface, this parameterization can be effectively used to compare features of a set of closed 3D surfaces point-to-point, while avoiding common problems with the parameterization of concave surfaces. From an initial segmentation of the livers, the areas of atypical local shape are determined using training sets. A geodesic active contour corrects locally the segmentations of the livers in abnormal images. Graph cuts segment the hepatic tumors using shape and enhancement constraints. Liver segmentation errors are reduced significantly and all tumors are detected. Finally, support vector machines and feature selection are employed to reduce the number of false tumor detections. The tumor detection true position fraction of 100% is achieved at 2.3 false positives/case and the tumor burden is estimated with 0.9% error. Results from the test data demonstrate the method's robustness to analyze livers from difficult clinical cases to allow the temporal monitoring of patients with hepatic cancer. PMID:22893379

Mathematical Analysis of Space Radiator Segmenting for Increased Reliability and Reduced Mass

NASA Technical Reports Server (NTRS)

Juhasz, Albert J.

2001-01-01

Spacecraft for long duration deep space missions will need to be designed to survive micrometeoroid bombardment of their surfaces some of which may actually be punctured. To avoid loss of the entire mission the damage due to such punctures must be limited to small, localized areas. This is especially true for power system radiators, which necessarily feature large surface areas to reject heat at relatively low temperature to the space environment by thermal radiation. It may be intuitively obvious that if a space radiator is composed of a large number of independently operating segments, such as heat pipes, a random micrometeoroid puncture will result only in the loss of the punctured segment, and not the entire radiator. Due to the redundancy achieved by independently operating segments, the wall thickness and consequently the weight of such segments can be drastically reduced. Probability theory is used to estimate the magnitude of such weight reductions as the number of segments is increased. An analysis of relevant parameter values required for minimum mass segmented radiators is also included.

Spatial nonuniformity of contraction causes arrhythmogenic Ca2+ waves in rat cardiac muscle.

PubMed

Ter Keurs, Henk E D J; Wakayama, Yuji; Miura, Masahito; Stuyvers, Bruno D; Boyden, Penelope A; Landesberg, Amir

2005-06-01

Landesberg and Sideman's four state model of the cardiac cross-bridge (XB) hypothesizes a feedback of force development to Ca(2+) binding by troponin C (TnC). We have further modeled this behavior and observed that the force (F)-Ca(2+) relationship as well as the F-sarcomere length (SL) relationship and the time course of F and Ca(2+) transients in cardiac muscle can be reproduced faithfully by a single effect of F on deformation of the TnC-Ca complex and, thereby, on the dissociation rate of Ca(2+). Furthermore, this feedback predicts that rapid decline of F in the activated sarcomere causes release of Ca(2+) from TnC-Ca(2+), which is sufficient to initiate arrhythmogenic Ca(2+) release from the sarcoplasmic reticulum (SR). This work investigated the initiation of Ca(2+) waves underlying triggered propagated contractions (TPCs) in rat cardiac trabeculae under conditions that simulate functional nonuniformity caused by mechanical or ischemic local damage of the myocardium. A mechanical discontinuity along the trabeculae was created by exposing the preparation to a small constant flow jet of solution that reduces excitation-contraction coupling in myocytes within that segment. Force was measured, and SL as well as [Ca(2+)](i) were measured regionally. When the jet contained caffeine, 2,3-butanedione monoxime or low-[Ca(2+)], muscle-twitch F decreased and the sarcomeres in the exposed segment were stretched by shortening the normal regions outside the jet. During relaxation, the sarcomeres in the exposed segment shortened rapidly. Short trains of stimulation at 2.5 Hz reproducibly caused Ca(2+) waves to rise from the borders exposed to the jet. Ca(2+) waves started during F relaxation of the last stimulated twitch and propagated into segments both inside and outside of the jet. Arrhythmias, in the form of nondriven rhythmic activity, were triggered when the amplitude of the Ca(2+) wave increased by raising [Ca(2+)](o). The arrhythmias disappeared when the muscle uniformity was restored by turning the jet off. These results show that nonuniform contraction can cause Ca(2+) waves underlying TPCs, and suggest that Ca(2+) dissociated from myofilaments plays an important role in the initiation of arrhythmogenic Ca(2+) waves.

Segmentation, surface rendering, and surface simplification of 3-D skull images for the repair of a large skull defect

NASA Astrophysics Data System (ADS)

Wan, Weibing; Shi, Pengfei; Li, Shuguang

2009-10-01

Given the potential demonstrated by research into bone-tissue engineering, the use of medical image data for the rapid prototyping (RP) of scaffolds is a subject worthy of research. Computer-aided design and manufacture and medical imaging have created new possibilities for RP. Accurate and efficient design and fabrication of anatomic models is critical to these applications. We explore the application of RP computational methods to the repair of a pediatric skull defect. The focus of this study is the segmentation of the defect region seen in computerized tomography (CT) slice images of this patient's skull and the three-dimensional (3-D) surface rendering of the patient's CT-scan data. We see if our segmentation and surface rendering software can improve the generation of an implant model to fill a skull defect.

Apparatus for and method of correcting for astigmatism in a light beam reflected off of a light reflecting surface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sawicki, R.H.; Sweatt, W.

1987-03-03

An apparatus is described for correcting for astigmatism in a light beam reflected off of a light reflecting surface, comprising: (a) a first means defining a flat, rectangular light reflecting surface which is resiliently bendable, to a limited extent, into different concave and/or convex cylindrical curvatures about a particular axis. The first means is configured so that the light reflecting surface can be adjustably bent into the selected cylindrical curvature by applying a particular bending moment to the first means with respect to the surface, depending upon the curvature desired. The first means includes an integrally formed body member havingmore » a main plate-like segment including a front fact defining the light reflecting surface and a pair of spaced-apart flange segments extending rearwardly of the main segment; and (b) second means acting on the first means for adjustably bending the light reflecting surface into a particular selected one of the different cylindrical curvatures, depending upon the astigmatism to be corrected for.« less

Absolute measurements of large mirrors

NASA Astrophysics Data System (ADS)

Su, Peng

The ability to produce mirrors for large astronomical telescopes is limited by the accuracy of the systems used to test the surfaces of such mirrors. Typically the mirror surfaces are measured by comparing their actual shapes to a precision master, which may be created using combinations of mirrors, lenses, and holograms. The work presented here develops several optical testing techniques that do not rely on a large or expensive precision, master reference surface. In a sense these techniques provide absolute optical testing. The Giant Magellan Telescope (GMT) has been designed with a 350 m 2 collecting area provided by a 25 m diameter primary mirror made out from seven circular independent mirror segments. These segments create an equivalent f/0.7 paraboloidal primary mirror consisting of a central segment and six outer segments. Each of the outer segments is 8.4 m in diameter and has an off-axis aspheric shape departing 14.5 mm from the best-fitting sphere. Much of the work in this dissertation is motivated by the need to measure the surfaces or such large mirrors accurately, without relying on a large or expensive precision reference surface. One method for absolute testing describing in this dissertation uses multiple measurements relative to a reference surface that is located in different positions with respect to the test surface of interest. The test measurements are performed with an algorithm that is based on the maximum likelihood (ML) method. Some methodologies for measuring large flat surfaces in the 2 m diameter range and for measuring the GMT primary mirror segments were specifically developed. For example, the optical figure of a 1.6-m flat mirror was determined to 2 nm rms accuracy using multiple 1-meter sub-aperture measurements. The optical figure of the reference surface used in the 1-meter sub-aperture measurements was also determined to the 2 nm level. The optical test methodology for a 1.7-m off axis parabola was evaluated by moving several times the mirror under test in relation to the test system. The result was a separation of errors in the optical test system to those errors from the mirror under test. This method proved to be accurate to 12nm rms. Another absolute measurement technique discussed in this dissertation utilizes the property of a paraboloidal surface of reflecting rays parallel to its optical axis, to its focal point. We have developed a scanning pentaprism technique that exploits this geometry to measure off-axis paraboloidal mirrors such as the GMT segments. This technique was demonstrated on a 1.7 m diameter prototype and proved to have a precision of about 50 nm rms.

Pharmacological and histological examinations of regional differences of guinea-pig lung: a role of pleural surface smooth muscle in lung strip contraction.

PubMed Central

Wong, W. S.; Bloomquist, S. L.; Bendele, A. M.; Fleisch, J. H.

1992-01-01

1. Parenchymal lung strip preparations have been widely used as an in vitro model of peripheral airway smooth muscle. The present study examined functional responses of 4 consecutive guinea-pig lung parenchymal strips isolated from the central region (segment 1) to the distal edge (segment 4) of the lower lung lobe. The middle two segments were designated as segments 2 and 3. 2. Lung segments 1 and 4 exhibited significantly greater contraction than the other 2 segments to KCl when responses were expressed as mg force per mg tissue weight. Contractile responses to bronchospastic agents including histamine, carbachol, endothelin-1, leukotrienes (LT) B4 and D4, and the thromboxane A2-mimetic U46619 demonstrated no significant difference in EC50 values among the 4 lung segments. 3. Contractile responses of segments 1 and 4 to antigen-challenge (ovalbumin), ionophore A23187 and substance P were significantly greater than the other 2 segments with respect to either sensitivity or maximum responsiveness. 4. U46619-induced contractions of the 4 lung segments were relaxed in similar manner by papaverine and theophylline up to 100%, salbutamol up to 80%, and sodium nitroprusside by only 20%. In contrast, sodium nitroprusside markedly reversed U46619-induced contraction of pulmonary arterial rings and bronchial rings. 5. Histological studies identified 2-4 layers of smooth muscle cells underlying the lung pleural surface. Mast cells were prominent in this area. Moreover, morphometric studies showed that segment 4 possessed the least amount of smooth muscle structures from bronchial/bronchiolar wall and vasculatures as compared to the other 3 segments, and a significant difference in this respect was evident between segment 1 and segment 4.(ABSTRACT TRUNCATED AT 250 WORDS) Images Figure 1 Figure 6 PMID:1378341

Maternally-Mediated Effects on Development*

EPA Science Inventory

In standard Segment II mammalian bioassays for developmental toxicity, it is the pregnant animal that is exposed to the test article, so in this sense, all in utero developmental toxicity is mediated by the mother. This will include absorption, distribution, metabolism and excret...

Learning-based automated segmentation of the carotid artery vessel wall in dual-sequence MRI using subdivision surface fitting.

PubMed

Gao, Shan; van 't Klooster, Ronald; Kitslaar, Pieter H; Coolen, Bram F; van den Berg, Alexandra M; Smits, Loek P; Shahzad, Rahil; Shamonin, Denis P; de Koning, Patrick J H; Nederveen, Aart J; van der Geest, Rob J

2017-10-01

The quantification of vessel wall morphology and plaque burden requires vessel segmentation, which is generally performed by manual delineations. The purpose of our work is to develop and evaluate a new 3D model-based approach for carotid artery wall segmentation from dual-sequence MRI. The proposed method segments the lumen and outer wall surfaces including the bifurcation region by fitting a subdivision surface constructed hierarchical-tree model to the image data. In particular, a hybrid segmentation which combines deformable model fitting with boundary classification was applied to extract the lumen surface. The 3D model ensures the correct shape and topology of the carotid artery, while the boundary classification uses combined image information of 3D TOF-MRA and 3D BB-MRI to promote accurate delineation of the lumen boundaries. The proposed algorithm was validated on 25 subjects (48 arteries) including both healthy volunteers and atherosclerotic patients with 30% to 70% carotid stenosis. For both lumen and outer wall border detection, our result shows good agreement between manually and automatically determined contours, with contour-to-contour distance less than 1 pixel as well as Dice overlap greater than 0.87 at all different carotid artery sections. The presented 3D segmentation technique has demonstrated the capability of providing vessel wall delineation for 3D carotid MRI data with high accuracy and limited user interaction. This brings benefits to large-scale patient studies for assessing the effect of pharmacological treatment of atherosclerosis by reducing image analysis time and bias between human observers. © 2017 American Association of Physicists in Medicine.

Estimating propagation velocity through a surface acoustic wave sensor

DOEpatents

Xu, Wenyuan; Huizinga, John S.

2010-03-16

Techniques are described for estimating the propagation velocity through a surface acoustic wave sensor. In particular, techniques which measure and exploit a proper segment of phase frequency response of the surface acoustic wave sensor are described for use as a basis of bacterial detection by the sensor. As described, use of velocity estimation based on a proper segment of phase frequency response has advantages over conventional techniques that use phase shift as the basis for detection.

Preliminary results in large bone segmentation from 3D freehand ultrasound

NASA Astrophysics Data System (ADS)

Fanti, Zian; Torres, Fabian; Arámbula Cosío, Fernando

2013-11-01

Computer Assisted Orthopedic Surgery (CAOS) requires a correct registration between the patient in the operating room and the virtual models representing the patient in the computer. In order to increase the precision and accuracy of the registration a set of new techniques that eliminated the need to use fiducial markers have been developed. The majority of these newly developed registration systems are based on costly intraoperative imaging systems like Computed Tomography (CT scan) or Magnetic resonance imaging (MRI). An alternative to these methods is the use of an Ultrasound (US) imaging system for the implementation of a more cost efficient intraoperative registration solution. In order to develop the registration solution with the US imaging system, the bone surface is segmented in both preoperative and intraoperative images, and the registration is done using the acquire surface. In this paper, we present the a preliminary results of a new approach to segment bone surface from ultrasound volumes acquired by means 3D freehand ultrasound. The method is based on the enhancement of the voxels that belongs to surface and its posterior segmentation. The enhancement process is based on the information provided by eigenanalisis of the multiscale 3D Hessian matrix. The preliminary results shows that from the enhance volume the final bone surfaces can be extracted using a singular value thresholding.

Laboratory testing of a building envelope segment based on cellular concrete

NASA Astrophysics Data System (ADS)

Fořt, Jan; Pavlík, Zbyšek; Černý, Robert

2016-07-01

Hygrothermal performance of a building envelope based on cellular concrete blocks is studied in the paper. Simultaneously, the strain fields induced by the heat and moisture changes are monitored. The studied wall is exposed to the climatic load corresponding to the winter climatic conditions of the moderate year for Prague. The winter climatic exposure is chosen in order to simulate the critical conditions of the building structure from the point of view of material performance and temperature and humidity loading. The evaluation of hygrothermal performance of a researched wall is done on the basis of relative humidity and temperature profiles measured along the cross section of the cellular concrete blocks. Strain gauges are fixed on the wall surface in expected orientation of the blocks expansion. The obtained results show a good hygrothermal function of the analyzed cellular concrete wall and its insignificant strain.

Reconstruction of incomplete cell paths through a 3D-2D level set segmentation

NASA Astrophysics Data System (ADS)

Hariri, Maia; Wan, Justin W. L.

2012-02-01

Segmentation of fluorescent cell images has been a popular technique for tracking live cells. One challenge of segmenting cells from fluorescence microscopy is that cells in fluorescent images frequently disappear. When the images are stacked together to form a 3D image volume, the disappearance of the cells leads to broken cell paths. In this paper, we present a segmentation method that can reconstruct incomplete cell paths. The key idea of this model is to perform 2D segmentation in a 3D framework. The 2D segmentation captures the cells that appear in the image slices while the 3D segmentation connects the broken cell paths. The formulation is similar to the Chan-Vese level set segmentation which detects edges by comparing the intensity value at each voxel with the mean intensity values inside and outside of the level set surface. Our model, however, performs the comparison on each 2D slice with the means calculated by the 2D projected contour. The resulting effect is to segment the cells on each image slice. Unlike segmentation on each image frame individually, these 2D contours together form the 3D level set function. By enforcing minimum mean curvature on the level set surface, our segmentation model is able to extend the cell contours right before (and after) the cell disappears (and reappears) into the gaps, eventually connecting the broken paths. We will present segmentation results of C2C12 cells in fluorescent images to illustrate the effectiveness of our model qualitatively and quantitatively by different numerical examples.

Impact assisted segmented cutterhead

DOEpatents

Morrell, Roger J.; Larson, David A.; Ruzzi, Peter L.

1992-01-01

An impact assisted segmented cutterhead device is provided for cutting various surfaces from coal to granite. The device comprises a plurality of cutting bit segments deployed in side by side relationship to form a continuous cutting face and a plurality of impactors individually associated with respective cutting bit segments. An impactor rod of each impactor connects that impactor to the corresponding cutting bit segment. A plurality of shock mounts dampening the vibration from the associated impactor. Mounting brackets are used in mounting the cutterhead to a base machine.

Optical performance of segmented aperture windows for solar tower receivers

NASA Astrophysics Data System (ADS)

Buck, Reiner

2017-06-01

Segmented quartz windows are a concept to build larger windows for receivers that require a closed aperture. Reflection losses are a significant loss factor for such solar receivers. Without any additional measures, the reflection loss can reach about 12%. One important measure to improve transmission is the application of anti-reflective coatings, which is beneficial in any case. Another option is modifying the window geometry, especially the edge surfaces of the glass segments. A certain fraction of the reflection losses are caused by a light-guide effect in the glass body, for rays entering through the front surface. Changing the cut surfaces in a way reducing the light-guide effect can significantly improve transmission of a segmented window. Several possible configurations are evaluated and discussed. The results of ray-tracing simulations verify the improvement. The final selection of the window configuration depends on the optical properties and on mechanical strength, manufacturing and cost considerations. This has to be evaluated for any specific receiver design.

Using additive manufacturing in accuracy evaluation of reconstructions from computed tomography.

PubMed

Smith, Erin J; Anstey, Joseph A; Venne, Gabriel; Ellis, Randy E

2013-05-01

Bone models derived from patient imaging and fabricated using additive manufacturing technology have many potential uses including surgical planning, training, and research. This study evaluated the accuracy of bone surface reconstruction of two diarthrodial joints, the hip and shoulder, from computed tomography. Image segmentation of the tomographic series was used to develop a three-dimensional virtual model, which was fabricated using fused deposition modelling. Laser scanning was used to compare cadaver bones, printed models, and intermediate segmentations. The overall bone reconstruction process had a reproducibility of 0.3 ± 0.4 mm. Production of the model had an accuracy of 0.1 ± 0.1 mm, while the segmentation had an accuracy of 0.3 ± 0.4 mm, indicating that segmentation accuracy was the key factor in reconstruction. Generally, the shape of the articular surfaces was reproduced accurately, with poorer accuracy near the periphery of the articular surfaces, particularly in regions with periosteum covering and where osteophytes were apparent.

Evidence for surface rupture in 1868 on the Hayward Fault in North Oakland and major rupturing in prehistoric earthquakes

NASA Astrophysics Data System (ADS)

Lienkaemper, James J.; Williams, Patrick L.

1999-07-01

WGCEP90 estimated the Hayward fault to have a high probability (0.45 in 30 yr) of producing a future M7 Bay Area earthquake. This was based on a generic recurrence time and an unverified segmentation model, because there were few direct observations for the southern fault and none for the northern Hayward fault. To better constrain recurrence and segmentation of the northern Hayward fault, we trenched in north Oakland. Unexpectedly, we observed evidence of surface rupture probably from the M7 1868 earthquake. This extends the limit of that surface rupture 13 km north of the segmentation boundary used in the WGCEP90 model and forces serious re-evaluation of the current two-segment paradigm. Although we found that major prehistoric ruptures have occurred here, we could not radiocarbon date them. However, the last major prehistoric event appears correlative with a recently recognized event 13 km to the north dated AD 1640-1776.

Evidence for surface rupture in 1868 on the Hayward fault in north Oakland and major rupturing in prehistoric earthquakes

USGS Publications Warehouse

Lienkaemper, J.J.; Williams, P.L.

1999-01-01

WGCEP90 estimated the Hayward fault to have a high probability (0.45 in 30 yr) of producing a future M7 Bay Area earthquake. This was based on a generic recurrence time and an unverified segmentation model, because there were few direct observations for the southern fault and none for the northern Hayward fault. To better constrain recurrence and segmentation of the northern Hayward fault, we trenched in north Oakland. Unexpectedly, we observed evidence of surface rupture probably from the M7 1868 earthquake. This extends the limit of that surface rupture 13 km north of the segmentation boundary used in the WGCEP90 model and forces serious re-evaluation of the current two-segment paradigm. Although we found that major prehistoric ruptures have occurred here, we could not radiocarbon date them. However, the last major prehistoric event appears correlative with a recently recognized event 13 km to the north dated AD 1640-1776. Copyright 1999 by the American Geophysical Union.

Automatic multi-organ segmentation using learning-based segmentation and level set optimization.

PubMed

Kohlberger, Timo; Sofka, Michal; Zhang, Jingdan; Birkbeck, Neil; Wetzl, Jens; Kaftan, Jens; Declerck, Jérôme; Zhou, S Kevin

2011-01-01

We present a novel generic segmentation system for the fully automatic multi-organ segmentation from CT medical images. Thereby we combine the advantages of learning-based approaches on point cloud-based shape representation, such a speed, robustness, point correspondences, with those of PDE-optimization-based level set approaches, such as high accuracy and the straightforward prevention of segment overlaps. In a benchmark on 10-100 annotated datasets for the liver, the lungs, and the kidneys we show that the proposed system yields segmentation accuracies of 1.17-2.89 mm average surface errors. Thereby the level set segmentation (which is initialized by the learning-based segmentations) contributes with an 20%-40% increase in accuracy.

Structures associated with strike-slip faults that bound landslide elements

USGS Publications Warehouse

Fleming, R.W.; Johnson, A.M.

1989-01-01

Large landslides are bounded on their flanks and on elements within the landslides by structures analogous to strike-slip faults. We observed the formation of thwse strike-slip faults and associated structures at two large landslides in central Utah during 1983-1985. The strike-slip faults in landslides are nearly vertical but locally may dip a few degrees toward or away from the moving ground. Fault surfaces are slickensided, and striations are subparallel to the ground surface. Displacement along strike-slip faults commonly produces scarps; scarps occur where local relief of the failure surface or ground surface is displaced and becomes adjacent to higher or lower ground, or where the landslide is thickening or thinning as a result of internal deformation. Several types of structures are formed at the ground surface as a strike-slip fault, which is fully developed at some depth below the ground surface, propagates upward in response to displacement. The simplest structure is a tension crack oriented at 45?? clockwise or counterclockwise from the trend of an underlying right- or left-lateral strike-slip fault, respectively. The tension cracks are typically arranged en echelon with the row of cracks parallel to the trace of the underlying strike-slip fault. Another common structure that forms above a developing strike-slip fault is a fault segment. Fault segments are discontinuous strike-slip faults that contain the same sense of slip but are turned clockwise or counterclockwise from a few to perhaps 20?? from the underlying strike-slip fault. The fault segments are slickensided and striated a few centimeters below the ground surface; continued displacement of the landslide causes the fault segments to open and a short tension crack propagates out of one or both ends of the fault segments. These structures, open fault segments containing a short tension crack, are termed compound cracks; and the short tension crack that propagates from the tip of the fault segment is typically oriented 45?? to the trend of the underlying fault. Fault segments are also typically arranged en echelon above the upward-propagating strike-slip fault. Continued displacement of the landslide causes the ground to buckle between the tension crack portions of the compound cracks. Still more displacement produces a thrust fault on one or both limbs of the buckle fold. These compressional structures form at right angles to the short tension cracks at the tips of the fault segments. Thus, the compressional structures are bounded on their ends by one face of a tension crack and detached from underlying material by thrusting or buckling. The tension cracks, fault segments, compound cracks, folds, and thrusts are ephemeral; they are created and destroyed with continuing displacement of the landslide. Ultimately, the structures are replaced by a throughgoing strike-slip fault. At one landslide, we observed the creation and destruction of the ephemeral structures as the landslide enlarged. Displacement of a few centimeters to about a decimeter was sufficient to produce scattered tension cracks and fault segments. Sets of compound cracks with associated folds and thrusts were produced by displacements of up to 1 m, and 1 to 2 m of displacement was required to produce a throughgoing strike-slip fault. The type of first-formed structure above an upward-propagating strike-slip fault is apparently controlled by the rheology of the material. Brittle material such as dry topsoil or the compact surface of a gravel road produces echelon tension cracks and sets of tension cracks and compressional structures, wherein the cracks and compressional structures are normal to each other and 45?? to the strike-slip fault at depth. First-formed structures in more ductile material such as moist cohesive soil are fault segments. In very ductile material such as soft clay and very wet soil in swampy areas, the first-formed structure is a throughgoing strike-slip fault. There are othe

Synthesis and controlled self-assembly of UV-responsive gold nanoparticles in block copolymer templates.

PubMed

Song, Dong-Po; Wang, Xinyu; Lin, Ying; Watkins, James J

2014-11-06

We demonstrate the facile synthesis of gold nanoparticles (GNPs) functionalized by UV-responsive block copolymer ligands, poly(styrene)-b-poly(o-nitrobenzene acrylate)-SH (PS-b-PNBA-SH), followed by their targeted distribution within a lamellae-forming poly(styrene)-b-poly(2-vinylpyridine) (PS-b-P2VP) block copolymer. The multilayer, micelle-like structure of the GNPs consists of a gold core, an inner PNBA layer, and an outer PS layer. The UV-sensitive PNBA segment can be deprotected into a layer containing poly(acrylic acid) (PAA) when exposed to UV light at 365 nm, which enables the simple and precise tuning of GNP surface properties from hydrophobic to amphiphilic. The GNPs bearing ligands of different chemical compositions were successfully and selectively incorporated into the PS-b-P2VP block copolymer, and UV light showed a profound influence on the spatial distributions of GNPs. Prior to UV exposure, GNPs partition along the interfaces of PS and P2VP domains, while the UV-treated GNPs are incorporated into P2VP domains as a result of hydrogen bond interactions between PAA on the gold surface and P2VP domains. This provides an easy way of controlling the arrangement of nanoparticles in polymer matrices by tailoring the nanoparticle surface using UV light.

Structural and functional analysis of the YAP-binding domain of human TEAD2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tian, Wei; Yu, Jianzhong; Tomchick, Diana R.

2010-06-15

The Hippo pathway controls organ size and suppresses tumorigenesis in metazoans by blocking cell proliferation and promoting apoptosis. The TEAD1-4 proteins (which contain a DNA-binding domain but lack an activation domain) interact with YAP (which lacks a DNA-binding domain but contains an activation domain) to form functional heterodimeric transcription factors that activate proliferative and prosurvival gene expression programs. The Hippo pathway inhibits the YAP-TEAD hybrid transcription factors by phosphorylating and promoting cytoplasmic retention of YAP. Here we report the crystal structure of the YAP-binding domain (YBD) of human TEAD2. TEAD2 YBD adopts an immunoglobulin-like {beta}-sandwich fold with two extra helix-turn-helixmore » inserts. NMR studies reveal that the TEAD-binding domain of YAP is natively unfolded and that TEAD binding causes localized conformational changes in YAP. In vitro binding and in vivo functional assays define an extensive conserved surface of TEAD2 YBD as the YAP-binding site. Therefore, our studies suggest that a short segment of YAP adopts an extended conformation and forms extensive contacts with a rigid surface of TEAD. Targeting a surface-exposed pocket of TEAD might be an effective strategy to disrupt the YAP-TEAD interaction and to reduce the oncogenic potential of YAP.« less

Effect of dimethyl sulfoxide wet-bonding technique on hybrid layer quality and dentin bond strength.

PubMed

Stape, Thiago Henrique Scarabello; Tjäderhane, Leo; Marques, Marcelo Rocha; Aguiar, Flávio Henrique Baggio; Martins, Luís Roberto Marcondes

2015-06-01

This study examined the effect of a dimethyl sulfoxide (DMSO) wet bonding technique on the resin infiltration depths at the bonded interface and dentin bond strength of different adhesive systems. Flat dentin surfaces of 48 human third molars were treated with 50% DMSO (experimental groups) or with distilled water (controls) before bonding using an etch-and-rinse (SBMP: Scotchbond Multi-Purpose, 3M ESPE) or a self-etch (Clearfil: Clearfil SE Bond, Kuraray) adhesive system. The restored crown segments (n=12/group) were stored in distilled water (24h) and sectioned for interfacial analysis of exposed collagen using Masson's Trichrome staining and for microtensile bond strength testing. The extent of exposed collagen was measured using light microscopy and a histometric analysis software. Failure modes were examined by SEM. Data was analyzed by two-way ANOVA followed by Tukey Test (α=0.05). The interaction of bonding protocol and adhesive system had significant effects on the extension of exposed collagen matrix (p<0.0001) and bond strength (p=0.0091). DMSO-wet bonding significantly reduced the extent of exposed collagen matrix for SBMP and Clearfil (p<0.05). Significant increase in dentin bond strength was observed on DMSO-treated specimens bonded with SBMP (p<0.05), while no differences were observed for Clearfil (p>0.05). DMSO-wet bonding was effective to improve the quality of resin-dentin bonds of the tested etch-and-rinse adhesives by reducing the extent of exposed collagen matrix at the base of the resin-dentin biopolymer. The improved penetration of adhesive monomers is reflected as an increase in the immediate bond strength when the DMSO-wet bonding technique is used with a water-based etch-and-rinse adhesive. Copyright © 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Interaction of the subduction process and forearc tectonics: An example from the active N - Chilean margin

NASA Astrophysics Data System (ADS)

Victor, P.; Sobiesiak, M.

2005-12-01

Convergent plate boundaries at continental margins belong to the tectonically most active areas on earth and are endangered by devastating earthquakes and tsunamis. The north Chilean margin is a high strain continental margin driven by fast plate convergence rate. The greatest amount of strain is accommodated along the subduction interface. Nevertheless there is extensive crustal deformation obvious by surface ruptures along reactivated segments of large fault systems and vertical surface motions reflecting the interaction between subducting and overriding plates. The historical seismicity record indicates that great earthquakes affect the Chilean Forearc with recurrence intervals of about 112+/- 21 y . The last great event in northern Chile occurred in 1995 near Antofagasta. The Mw= 8.0 event ruptured the subduction interface 180 km along strike with an average slip of about 5m in the depth interval between 10-50 km. From careful evaluation of the aftershock sequence by examining the different catagories of aftershock focal mechanisms we can define three segments of the seismogenic zone affected by the Antofagasta main shock. The non-ruptured northern segment beneath Mejillones Peninsula is seperated by a broad transition zone from the central segment which hosts the earthquakes' rupture plane. The southern fault plane boundary is identified by linear alignment of all apparent aftershock mechanisms. Along this southern boundary the strike slip mechanisms are exclusively left lateral whereas the strike slip mechanisms along the northern transition zone are right lateral. The orientations of summed moment tensors calculated from aftershock fault plane solutions on the northern segment and in the northern transition zone differ from the orientations exhibited by moment tensors on the central segment. This might indicate a rotational component in the coseismic movement of the ruptured segment relative to the non-ruptured segment. The observed segmentation of the downgoing plate correlates well with changes in the coseismic surface displacement field and coseismic rotations derived from GPS data (Allmendinger et al. in press). We can localize a transition zone at Mejillones peninsula (23,5°S) striking approximately N 80°E dominated by clockwise vertical axis rotations also marked by rotations of the summed moment tensors on the downgoing plate. The calculated strain tensor for this transition zone does not correspond with long term surface deformation, implying that coseismic as well as early postseismic effects on the subduction interface do not contribute to long term deformation of crustal fault zones. The Antofagasta earthquake took place just south of the large 1877 gap which extends from southern Peru to Mejillones Peninsula, being the surface expression of a barrier seperating the Antofagasta fault plane from the expected future fault plane. From our studies of the Antofagasta subduction zone and the surface displacement field we hope to find evidences for interface-crust-surface interactions which can be extrapolated also to the 1877 gap.

Segmentation of the heart and major vascular structures in cardiovascular CT images

NASA Astrophysics Data System (ADS)

Peters, J.; Ecabert, O.; Lorenz, C.; von Berg, J.; Walker, M. J.; Ivanc, T. B.; Vembar, M.; Olszewski, M. E.; Weese, J.

2008-03-01

Segmentation of organs in medical images can be successfully performed with shape-constrained deformable models. A surface mesh is attracted to detected image boundaries by an external energy, while an internal energy keeps the mesh similar to expected shapes. Complex organs like the heart with its four chambers can be automatically segmented using a suitable shape variablility model based on piecewise affine degrees of freedom. In this paper, we extend the approach to also segment highly variable vascular structures. We introduce a dedicated framework to adapt an extended mesh model to freely bending vessels. This is achieved by subdividing each vessel into (short) tube-shaped segments ("tubelets"). These are assigned to individual similarity transformations for local orientation and scaling. Proper adaptation is achieved by progressively adapting distal vessel parts to the image only after proximal neighbor tubelets have already converged. In addition, each newly activated tubelet inherits the local orientation and scale of the preceeding one. To arrive at a joint segmentation of chambers and vasculature, we extended a previous model comprising endocardial surfaces of the four chambers, the left ventricular epicardium, and a pulmonary artery trunk. Newly added are the aorta (ascending and descending plus arch), superior and inferior vena cava, coronary sinus, and four pulmonary veins. These vessels are organized as stacks of triangulated rings. This mesh configuration is most suitable to define tubelet segments. On 36 CT data sets reconstructed at several cardiac phases from 17 patients, segmentation accuracies of 0.61-0.80mm are obtained for the cardiac chambers. For the visible parts of the newly added great vessels, surface accuracies of 0.47-1.17mm are obtained (larger errors are asscociated with faintly contrasted venous structures).

3D segmentation of kidney tumors from freehand 2D ultrasound

NASA Astrophysics Data System (ADS)

Ahmad, Anis; Cool, Derek; Chew, Ben H.; Pautler, Stephen E.; Peters, Terry M.

2006-03-01

To completely remove a tumor from a diseased kidney, while minimizing the resection of healthy tissue, the surgeon must be able to accurately determine its location, size and shape. Currently, the surgeon mentally estimates these parameters by examining pre-operative Computed Tomography (CT) images of the patient's anatomy. However, these images do not reflect the state of the abdomen or organ during surgery. Furthermore, these images can be difficult to place in proper clinical context. We propose using Ultrasound (US) to acquire images of the tumor and the surrounding tissues in real-time, then segmenting these US images to present the tumor as a three dimensional (3D) surface. Given the common use of laparoscopic procedures that inhibit the range of motion of the operator, we propose segmenting arbitrarily placed and oriented US slices individually using a tracked US probe. Given the known location and orientation of the US probe, we can assign 3D coordinates to the segmented slices and use them as input to a 3D surface reconstruction algorithm. We have implemented two approaches for 3D segmentation from freehand 2D ultrasound. Each approach was evaluated on a tissue-mimicking phantom of a kidney tumor. The performance of our approach was determined by measuring RMS surface error between the segmentation and the known gold standard and was found to be below 0.8 mm.

Fermi surface and quantum well states of V(110) films on W(110)

NASA Astrophysics Data System (ADS)

Krupin, Oleg; Rotenberg, Eli; Kevan, S. D.

2007-09-01

Using angle-resolved photoemission spectroscopy, we have measured the Fermi surface of V(110) films epitaxially grown on a W(110) substrate. We compare our results for thicker films to existing calculations and measurements for bulk vanadium and find generally very good agreement. For thinner films, we observe and analyse a diverse array of quantum well states that split and distort the Fermi surface segments. We have searched unsuccessfully for a thickness-induced topological transition associated with contact between the zone-centre jungle gym and zone-boundary hole ellipsoid Fermi surface segments. We also find no evidence for ferromagnetic splitting of any bands on this surface.

Design and fabrication of Ni nanowires having periodically hollow nanostructures

NASA Astrophysics Data System (ADS)

Sada, Takao; Fujigaya, Tsuyohiko; Nakashima, Naotoshi

2014-09-01

We propose a concept for the design and fabrication of metal nanowires having periodically hollow nanostructures inside the pores of an anodic aluminum oxide (AAO) membrane using a sacrificial metal. In this study, nickel (Ni) and silver (Ag) were used as the base metal and the sacrificial metal, respectively. Alternating an applied potential between -0.4 and -1.0 V provided alternatively deposited Ni and Ag segments in a Ni-Ag `barcode' nanowire with a diameter of 18 or 35 nm. After etching away the Ag segments, we fabricated Ni nanowires with nanopores of 12 +/- 5.3 nm. Such nanostructure formation is explained by the formation of a Ni shell layer over the surface of the Ag segments due to the strong affinity of Ni2+ for the interior surfaces of AAO. The Ni shell layer allows the Ni segments to remain even after dissolution of the Ag segments. Because the electroplating conditions can be easily controlled, we could carefully adjust the size and pitch of the periodically hollow nanospaces. We also describe a method for the fabrication of Ni nanorods by forming an Ag shell instead of a Ni shell on the Ni-Ag barcode nanowire, in which the interior of the AAO surfaces was modified with a compound bearing a thiol group prior to electroplating.We propose a concept for the design and fabrication of metal nanowires having periodically hollow nanostructures inside the pores of an anodic aluminum oxide (AAO) membrane using a sacrificial metal. In this study, nickel (Ni) and silver (Ag) were used as the base metal and the sacrificial metal, respectively. Alternating an applied potential between -0.4 and -1.0 V provided alternatively deposited Ni and Ag segments in a Ni-Ag `barcode' nanowire with a diameter of 18 or 35 nm. After etching away the Ag segments, we fabricated Ni nanowires with nanopores of 12 +/- 5.3 nm. Such nanostructure formation is explained by the formation of a Ni shell layer over the surface of the Ag segments due to the strong affinity of Ni2+ for the interior surfaces of AAO. The Ni shell layer allows the Ni segments to remain even after dissolution of the Ag segments. Because the electroplating conditions can be easily controlled, we could carefully adjust the size and pitch of the periodically hollow nanospaces. We also describe a method for the fabrication of Ni nanorods by forming an Ag shell instead of a Ni shell on the Ni-Ag barcode nanowire, in which the interior of the AAO surfaces was modified with a compound bearing a thiol group prior to electroplating. Electronic supplementary information (ESI) available: Information on the current profile during pulsed-electroplating, the histogram for the Ni and nanopores, and STEM images of obtained nanowires. See DOI: 10.1039/c4nr02625j

Automatic segmentation of the bone and extraction of the bone cartilage interface from magnetic resonance images of the knee

NASA Astrophysics Data System (ADS)

Fripp, Jurgen; Crozier, Stuart; Warfield, Simon K.; Ourselin, Sébastien

2007-03-01

The accurate segmentation of the articular cartilages from magnetic resonance (MR) images of the knee is important for clinical studies and drug trials into conditions like osteoarthritis. Currently, segmentations are obtained using time-consuming manual or semi-automatic algorithms which have high inter- and intra-observer variabilities. This paper presents an important step towards obtaining automatic and accurate segmentations of the cartilages, namely an approach to automatically segment the bones and extract the bone-cartilage interfaces (BCI) in the knee. The segmentation is performed using three-dimensional active shape models, which are initialized using an affine registration to an atlas. The BCI are then extracted using image information and prior knowledge about the likelihood of each point belonging to the interface. The accuracy and robustness of the approach was experimentally validated using an MR database of fat suppressed spoiled gradient recall images. The (femur, tibia, patella) bone segmentation had a median Dice similarity coefficient of (0.96, 0.96, 0.89) and an average point-to-surface error of 0.16 mm on the BCI. The extracted BCI had a median surface overlap of 0.94 with the real interface, demonstrating its usefulness for subsequent cartilage segmentation or quantitative analysis.

An algorithm for calculi segmentation on ureteroscopic images.

PubMed

Rosa, Benoît; Mozer, Pierre; Szewczyk, Jérôme

2011-03-01

The purpose of the study is to develop an algorithm for the segmentation of renal calculi on ureteroscopic images. In fact, renal calculi are common source of urological obstruction, and laser lithotripsy during ureteroscopy is a possible therapy. A laser-based system to sweep the calculus surface and vaporize it was developed to automate a very tedious manual task. The distal tip of the ureteroscope is directed using image guidance, and this operation is not possible without an efficient segmentation of renal calculi on the ureteroscopic images. We proposed and developed a region growing algorithm to segment renal calculi on ureteroscopic images. Using real video images to compute ground truth and compare our segmentation with a reference segmentation, we computed statistics on different image metrics, such as Precision, Recall, and Yasnoff Measure, for comparison with ground truth. The algorithm and its parameters were established for the most likely clinical scenarii. The segmentation results are encouraging: the developed algorithm was able to correctly detect more than 90% of the surface of the calculi, according to an expert observer. Implementation of an algorithm for the segmentation of calculi on ureteroscopic images is feasible. The next step is the integration of our algorithm in the command scheme of a motorized system to build a complete operating prototype.

Automatic segmentation of the liver using multi-planar anatomy and deformable surface model in abdominal contrast-enhanced CT images

NASA Astrophysics Data System (ADS)

Jang, Yujin; Hong, Helen; Chung, Jin Wook; Yoon, Young Ho

2012-02-01

We propose an effective technique for the extraction of liver boundary based on multi-planar anatomy and deformable surface model in abdominal contrast-enhanced CT images. Our method is composed of four main steps. First, for extracting an optimal volume circumscribing a liver, lower and side boundaries are defined by positional information of pelvis and rib. An upper boundary is defined by separating the lungs and heart from CT images. Second, for extracting an initial liver volume, optimal liver volume is smoothed by anisotropic diffusion filtering and is segmented using adaptively selected threshold value. Third, for removing neighbor organs from initial liver volume, morphological opening and connected component labeling are applied to multiple planes. Finally, for refining the liver boundaries, deformable surface model is applied to a posterior liver surface and missing left robe in previous step. Then, probability summation map is generated by calculating regional information of the segmented liver in coronal plane, which is used for restoring the inaccurate liver boundaries. Experimental results show that our segmentation method can accurately extract liver boundaries without leakage to neighbor organs in spite of various liver shape and ambiguous boundary.

Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Diagnosis and Management of Ocular Surface Squamous Neoplasia

PubMed Central

Thomas, Benjamin J.; Galor, Anat; Nanji, Afshan A.; Sayyad, Fouad El; Wang, Jianhua; Dubovy, Sander R.; Joag, Madhura G.; Karp, Carol L.

2014-01-01

The development of optical coherence tomography (OCT) technology has helped to usher in a new era of in vivo diagnostic imaging of the eye. The utilization of OCT for imaging of the anterior segment and ocular surface has evolved from time-domain devices to spectral-domain devices with greater penetrance and resolution, providing novel images of anterior segment pathology to assist in diagnosis and management of disease. Ocular surface squamous neoplasia (OSSN) is one such pathology that has proven demonstrable by certain anterior segment OCT machines, specifically the newer devices capable of performing ultra high-resolution OCT (UHR-OCT). Distinctive features of OSSN on high resolution OCT allow for diagnosis and differentiation from other ocular surface pathologies. Subtle findings on these images help to characterize the OSSN lesions beyond what is apparent with the clinical examination, providing guidance for clinical management. The purpose of this review is to examine the published literature on the utilization of UHR-OCT for the diagnosis and management of OSSN, as well as to report novel uses of this technology and potential directions for its future development. PMID:24439046

Aniridia and Brachmann-de Lange syndrome: a review of ocular surface and anterior segment findings.

PubMed

Lee, W Barry; Brandt, James D; Mannis, Mark J; Huang, Charles Q; Rabin, Gregory J

2003-03-01

To review the ocular surface and anterior segment findings in Brachmann-de Lange syndrome and describe a new case involving aniridia and congenital glaucoma. A newborn presented 2 days after birth with bilateral cloudy corneas, photophobia, and epiphora. We provide a 5-year descriptive history and clinical course with review of the literature on Brachmann-de Lange syndrome. Multiple ocular surgeries were performed for ocular sequelae from aniridia and congenital glaucoma including Ahmed valve placement and penetrating keratoplasties in both eyes. At 5.5 years of age, the child had a clear graft OD and amblyopia from graft failure OS following recurrent graft infections. A review of Brachmann-de Lange syndrome found 43 patients with ocular surface and anterior segment findings. The most common findings included conjunctivitis, blepharitis, microcornea, and corectopia. Aniridia and congenital glaucoma were not previously reported with Brachmann-de Lange syndrome. Ocular surface and anterior segment abnormalities must be considered when examining patients with Brachmann-de Lange syndrome. Ocular findings may include vision-threatening anomalies, as in our case with aniridia and congenital glaucoma. To our knowledge, these findings are previously unreported in Brachmann-de Lange syndrome.

Machine learning in a graph framework for subcortical segmentation

NASA Astrophysics Data System (ADS)

Guo, Zhihui; Kashyap, Satyananda; Sonka, Milan; Oguz, Ipek

2017-02-01

Automated and reliable segmentation of subcortical structures from human brain magnetic resonance images is of great importance for volumetric and shape analyses in quantitative neuroimaging studies. However, poor boundary contrast and variable shape of these structures make the automated segmentation a tough task. We propose a 3D graph-based machine learning method, called LOGISMOS-RF, to segment the caudate and the putamen from brain MRI scans in a robust and accurate way. An atlas-based tissue classification and bias-field correction method is applied to the images to generate an initial segmentation for each structure. Then a 3D graph framework is utilized to construct a geometric graph for each initial segmentation. A locally trained random forest classifier is used to assign a cost to each graph node. The max-flow algorithm is applied to solve the segmentation problem. Evaluation was performed on a dataset of T1-weighted MRI's of 62 subjects, with 42 images used for training and 20 images for testing. For comparison, FreeSurfer, FSL and BRAINSCut approaches were also evaluated using the same dataset. Dice overlap coefficients and surface-to-surfaces distances between the automated segmentation and expert manual segmentations indicate the results of our method are statistically significantly more accurate than the three other methods, for both the caudate (Dice: 0.89 +/- 0.03) and the putamen (0.89 +/- 0.03).

Motion in the north Iceland volcanic rift zone accommodated by bookshelf faulting

NASA Astrophysics Data System (ADS)

Green, Robert G.; White, Robert S.; Greenfield, Tim

2014-01-01

Along mid-ocean ridges the extending crust is segmented on length scales of 10-1,000km. Where rift segments are offset from one another, motion between segments is accommodated by transform faults that are oriented orthogonally to the main rift axis. Where segments overlap, non-transform offsets with a variety of geometries accommodate shear motions. Here we use micro-seismic data to analyse the geometries of faults at two overlapping rift segments exposed on land in north Iceland. Between the rift segments, we identify a series of faults that are aligned sub-parallel to the orientation of the main rift. These faults slip through left-lateral strike-slip motion. Yet, movement between the overlapping rift segments is through right-lateral motion. Together, these motions induce a clockwise rotation of the faults and intervening crustal blocks in a motion that is consistent with a bookshelf-faulting mechanism, named after its resemblance to a tilting row of books on a shelf. The faults probably reactivated existing crustal weaknesses, such as dyke intrusions, that were originally oriented parallel to the main rift and have since rotated about 15° clockwise. Reactivation of pre-existing, rift-parallel weaknesses contrasts with typical mid-ocean ridge transform faults and is an important illustration of a non-transform offset accommodating shear motion between overlapping rift segments.

Registration-based segmentation with articulated model from multipostural magnetic resonance images for hand bone motion animation.

PubMed

Chen, Hsin-Chen; Jou, I-Ming; Wang, Chien-Kuo; Su, Fong-Chin; Sun, Yung-Nien

2010-06-01

The quantitative measurements of hand bones, including volume, surface, orientation, and position are essential in investigating hand kinematics. Moreover, within the measurement stage, bone segmentation is the most important step due to its certain influences on measuring accuracy. Since hand bones are small and tubular in shape, magnetic resonance (MR) imaging is prone to artifacts such as nonuniform intensity and fuzzy boundaries. Thus, greater detail is required for improving segmentation accuracy. The authors then propose using a novel registration-based method on an articulated hand model to segment hand bones from multipostural MR images. The proposed method consists of the model construction and registration-based segmentation stages. Given a reference postural image, the first stage requires construction of a drivable reference model characterized by hand bone shapes, intensity patterns, and articulated joint mechanism. By applying the reference model to the second stage, the authors initially design a model-based registration pursuant to intensity distribution similarity, MR bone intensity properties, and constraints of model geometry to align the reference model to target bone regions of the given postural image. The authors then refine the resulting surface to improve the superimposition between the registered reference model and target bone boundaries. For each subject, given a reference postural image, the proposed method can automatically segment all hand bones from all other postural images. Compared to the ground truth from two experts, the resulting surface image had an average margin of error within 1 mm (mm) only. In addition, the proposed method showed good agreement on the overlap of bone segmentations by dice similarity coefficient and also demonstrated better segmentation results than conventional methods. The proposed registration-based segmentation method can successfully overcome drawbacks caused by inherent artifacts in MR images and obtain more accurate segmentation results automatically. Moreover, realistic hand motion animations can be generated based on the bone segmentation results. The proposed method is found helpful for understanding hand bone geometries in dynamic postures that can be used in simulating 3D hand motion through multipostural MR images.

Characterization of basin concrete in support of structural integrity demonstration for extended storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, A.

Concrete core samples from C basin were characterized through material testing and analysis to verify the design inputs for structural analysis of the L Basin and to evaluate the type and extent of changes in the material condition of the concrete under extended service for fuel storage. To avoid the impact on operations, core samples were not collected from L area, but rather, several concrete core samples were taken from the C Basin prior to its closure. C basin was selected due to its similar environmental exposure and service history compared to L Basin. The microstructure and chemical composition ofmore » the concrete exposed to the water was profiled from the water surface into the wall to evaluate the impact and extent of exposure. No significant leaching of concrete components was observed. Ingress of carbonation or deleterious species was determined to be insignificant. No evidence of alkali-silica reactions (ASR) was observed. Ettringite was observed to form throughout the structure (in air voids or pores); however, the sulfur content was measured to be consistent with the initial concrete that was used to construct the facility. Similar ettringite trends were observed in the interior segments of the core samples. The compressive strength of the concrete at the mid-wall of the basin was measured, and similar microstructural analysis was conducted on these materials post compression testing. The microstructure was determined to be similar to near-surface segments of the core samples. The average strength was 4148 psi, which is well-above the design strength of 2500 psi. The analyses showed that phase alterations and minor cracking in a microstructure did not affect the design specification for the concrete.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Almus, F.E.; Rao, L.V.; Fleck, R.A.

An umbilical vein model was designed in which washed vein segments are filled with a reaction mixture containing factor VIIa, Ca(+)+, and a substrate, either 3H-factor IX or 3H-factor X. The vein wall provides the tissue factor (TF) for factor VIIa/TF complexes that activate the substrates as measured by activation peptide release. The model was developed to study TF induced on venous endothelium in situ. However, unlike previous studies with TF expressed on cultured umbilical vein endothelial cells, factors IX and X were activated without first having to expose the vein wall to a perturbing stimulus. Histologic studies revealed thatmore » washing the vein and mixing the reaction mixture before subsampling had disrupted the endothelium. Immunostaining with anti-TF antibodies revealed no staining of endothelium but intense staining in extensions of Wharton's jelly penetrating fenestrations of the muscularis media of the vein. Thus, the model provided data on factor VIIa/TF formed, not on endothelium, but within the mucoid connective tissue of Wharton's jelly. It is known that factor VIIa/TF formed with TF in suspension or with TF expressed on the surface of cultured cells activates factor X more rapidly than factor IX. In contrast, in the umbilical vein model, when each substrate was present in an 88 nmol/L concentration, factors IX and X were activated at equivalent rates (mean activation rate for factor IX, 18.8 +/- 3.6 nmol/L/h; for factor X, 17.8 +/- 2.9 nmol/L/h; n = 9 paired vein segments). These data strengthen the evidence that factor VIIa/TF activation of factor IX represents a key initial reaction of coagulation in tissues. These results also show that data obtained with factor VIIa/TF complexes formed on the surface of cultured cells need not hold for factor VIIa/TF complexes formed in extracellular matrix.« less

Production of immunologically active surface antigens of hepatitis B virus by Escherichia coli.

PubMed Central

MacKay, P; Pasek, M; Magazin, M; Kovacic, R T; Allet, B; Stahl, S; Gilbert, W; Schaller, H; Bruce, S A; Murray, K

1981-01-01

Several plasmids have been constructed which direct the synthesis of hepatitis B virus surface antigens in Escherichia coli either as the native polypeptide or fused to other plasmid encoded polypeptides. When injected into rabbits, extracts from bacteria carrying some of these plasmids induced the synthesis of antibodies to the antigens even though the extracts did not give satisfactory positive results in radioimmunoassay for them. Either the NH2-terminal segment or the COOH-terminal segment of the surface antigens alone was sufficient to elicit the immune response, but antibodies against the two segments showed different specificities. The results emphasize the value of an in vivo assay for the presence of antigens in crude cell extracts and illustrate the feasibility of this type of screening with laboratory animals. PMID:6170067

Simulating the Structural Response of a Preloaded Bolted Joint

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Phillips, Dawn R.; Raju, Ivatury S.

2008-01-01

The present paper describes the structural analyses performed on a preloaded bolted-joint configuration. The joint modeled was comprised of two L-shaped structures connected together using a single bolt. Each L-shaped structure involved a vertical flat segment (or shell wall) welded to a horizontal segment (or flange). Parametric studies were performed using elasto-plastic, large-deformation nonlinear finite element analyses to determine the influence of several factors on the bolted-joint response. The factors considered included bolt preload, washer-surface-bearing size, edge boundary conditions, joint segment length, and loading history. Joint response is reported in terms of displacements, gap opening, and surface strains. Most of the factors studied were determined to have minimal effect on the bolted-joint response; however, the washer-bearing-surface size affected the response significantly.

Dissimilar Kinetic Behavior of Electrically Manipulated Single- and Double-Stranded DNA Tethered to a Gold Surface

PubMed Central

Rant, Ulrich; Arinaga, Kenji; Tornow, Marc; Kim, Yong Woon; Netz, Roland R.; Fujita, Shozo; Yokoyama, Naoki; Abstreiter, Gerhard

2006-01-01

We report on the electrical manipulation of single- and double-stranded oligodeoxynucleotides that are end tethered to gold surfaces in electrolyte solution. The response to alternating repulsive and attractive electric surface fields is studied by time-resolved fluorescence measurements, revealing markedly distinct dynamics for the flexible single-stranded and stiff double-stranded DNA, respectively. Hydrodynamic simulations rationalize this finding and disclose two different kinetic mechanisms: stiff polymers undergo rotation around the anchoring pivot point; flexible polymers, on the other hand, are pulled onto the attracting surface segment by segment. PMID:16473909

Dissimilar kinetic behavior of electrically manipulated single- and double-stranded DNA tethered to a gold surface.

PubMed

Rant, Ulrich; Arinaga, Kenji; Tornow, Marc; Kim, Yong Woon; Netz, Roland R; Fujita, Shozo; Yokoyama, Naoki; Abstreiter, Gerhard

2006-05-15

We report on the electrical manipulation of single- and double-stranded oligodeoxynucleotides that are end tethered to gold surfaces in electrolyte solution. The response to alternating repulsive and attractive electric surface fields is studied by time-resolved fluorescence measurements, revealing markedly distinct dynamics for the flexible single-stranded and stiff double-stranded DNA, respectively. Hydrodynamic simulations rationalize this finding and disclose two different kinetic mechanisms: stiff polymers undergo rotation around the anchoring pivot point; flexible polymers, on the other hand, are pulled onto the attracting surface segment by segment.

40 CFR 761.247 - Sample site selection for pipe segment removal.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.247 Sample site selection for pipe segment removal. (a) General. (1) Select the pipe... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Sample site selection for pipe segment...

40 CFR 761.247 - Sample site selection for pipe segment removal.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Sample site selection for pipe segment... Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.247 Sample site selection for pipe segment removal. (a) General. (1) Select the pipe...

Speed tuning of motion segmentation and discrimination

NASA Technical Reports Server (NTRS)

Masson, G. S.; Mestre, D. R.; Stone, L. S.

1999-01-01

Motion transparency requires that the visual system distinguish different motion vectors and selectively integrate similar motion vectors over space into the perception of multiple surfaces moving through or over each other. Using large-field (7 degrees x 7 degrees) displays containing two populations of random-dots moving in the same (horizontal) direction but at different speeds, we examined speed-based segmentation by measuring the speed difference above which observers can perceive two moving surfaces. We systematically investigated this 'speed-segmentation' threshold as a function of speed and stimulus duration, and found that it increases sharply for speeds above approximately 8 degrees/s. In addition, speed-segmentation thresholds decrease with stimulus duration out to approximately 200 ms. In contrast, under matched conditions, speed-discrimination thresholds stay low at least out to 16 degrees/s and decrease with increasing stimulus duration at a faster rate than for speed segmentation. Thus, motion segmentation and motion discrimination exhibit different speed selectivity and different temporal integration characteristics. Results are discussed in terms of the speed preferences of different neuronal populations within the primate visual cortex.

Protein folding: understanding the role of water and the low Reynolds number environment as the peptide chain emerges from the ribosome and folds.

PubMed

Sen, Siddhartha; Voorheis, H Paul

2014-12-21

The mechanism of protein folding during early stages of the process has three determinants. First, moving water molecules obey the rules of low Reynolds number physics without an inertial component. Molecular movement is instantaneous and size insensitive. Proteins emerging from the ribosome move and rotate without an external force if they change shape, forming and propagating helical structures that increases translocational efficiency. Forward motion ceases when the shape change or propelling force ceases. Second, application of quantum field theory to water structure predicts the spontaneous formation of low density coherent units of fixed size that expel dissolved atmospheric gases. Structured water layers with both coherent and non-coherent domains, form a sheath around the new protein. The surface of exposed hydrophobic amino acids is protected from water contact by small nanobubbles of dissolved atmospheric gases, 5 or 6 molecules on average, that vibrate, attracting even widely separated resonating nanobubbles. This force results from quantum effects, appearing only when the system is within and interacts with an oscillating electromagnetic field. The newly recognized quantum force sharply bends the peptide and is part of a dynamic field determining the pathway of protein folding. Third, the force initiating the tertiary folding of proteins arises from twists at the position of each hydrophobic amino acid, that minimizes surface exposure of the hydrophobic amino acids and propagates along the protein. When the total bend reaches 360°, the leading segment of water sheath intersects the trailing segment. This steric self-intersection expels water from overlapping segments of the sheath and by Newton׳s second law moves the polypeptide chain in an opposite direction. Consequently, with very few exceptions that we enumerate and discuss, tertiary structures are absent from proteins without hydrophobic amino acids, which control the early stages of protein folding and the overall shape of protein. Consequently, proteins only adopt a limited number of forms. The formation of quaternary structures is not necessarily prevented by the absence of hydrophobic amino acids. Copyright © 2014 Elsevier Ltd. All rights reserved.

Insights into the relationship between surface and subsurface activity from mechanical modeling of the 1992 Landers M7.3 earthquake

NASA Astrophysics Data System (ADS)

Madden, E. H.; Pollard, D. D.

2009-12-01

Multi-fault, strike-slip earthquakes have proved difficult to incorporate into seismic hazard analyses due to the difficulty of determining the probability of these ruptures, despite collection of extensive data associated with such events. Modeling the mechanical behavior of these complex ruptures contributes to a better understanding of their occurrence by elucidating the relationship between surface and subsurface earthquake activity along transform faults. This insight is especially important for hazard mitigation, as multi-fault systems can produce earthquakes larger than those associated with any one fault involved. We present a linear elastic, quasi-static model of the southern portion of the 28 June 1992 Landers earthquake built in the boundary element software program Poly3D. This event did not rupture the extent of any one previously mapped fault, but trended 80km N and NW across segments of five sub-parallel, N-S and NW-SE striking faults. At M7.3, the earthquake was larger than the potential earthquakes associated with the individual faults that ruptured. The model extends from the Johnson Valley Fault, across the Landers-Kickapoo Fault, to the Homestead Valley Fault, using data associated with a six-week time period following the mainshock. It honors the complex surface deformation associated with this earthquake, which was well exposed in the desert environment and mapped extensively in the field and from aerial photos in the days immediately following the earthquake. Thus, the model incorporates the non-linearity and segmentation of the main rupture traces, the irregularity of fault slip distributions, and the associated secondary structures such as strike-slip splays and thrust faults. Interferometric Synthetic Aperture Radar (InSAR) images of the Landers event provided the first satellite images of ground deformation caused by a single seismic event and provide constraints on off-fault surface displacement in this six-week period. Insight is gained by comparing the density, magnitudes and focal plane orientations of relocated aftershocks for this time frame with the magnitude and orientation of planes of maximum Coulomb shear stress around the fault planes at depth.

Abrasion and fatigue resistance of PDMS containing multiblock polyurethanes after accelerated water exposure at elevated temperature.

PubMed

Chaffin, Kimberly A; Wilson, Charles L; Himes, Adam K; Dawson, James W; Haddad, Tarek D; Buckalew, Adam J; Miller, Jennifer P; Untereker, Darrel F; Simha, Narendra K

2013-11-01

Segmented polyurethane multiblock polymers containing polydimethylsiloxane and polyether soft segments form tough and easily processed thermoplastic elastomers (PDMS-urethanes). Two commercially available examples, PurSil 35 (denoted as P35) and Elast-Eon E2A (denoted as E2A), were evaluated for abrasion and fatigue resistance after immersion in 85 °C buffered water for up to 80 weeks. We previously reported that water exposure in these experiments resulted in a molar mass reduction, where the kinetics of the hydrolysis reaction is supported by a straight forward Arrhenius analysis over a range of accelerated temperatures (37-85 °C). We also showed that the ultimate tensile properties of P35 and E2A were significantly compromised when the molar mass was reduced. Here, we show that the reduction in molar mass also correlated with a reduction in both the abrasion and fatigue resistance. The instantaneous wear rate of both P35 and E2A, when exposed to the reciprocating motion of an ethylene tetrafluoroethylene (ETFE) jacketed cable, increased with the inverse of the number averaged molar mass (1/Mn). Both materials showed a change in the wear surface when the number-averaged molar mass was reduced to ≈ 16 kg/mole, where a smooth wear surface transitioned to a 'spalling-like' pattern, leaving the wear surface with ≈ 0.3 mm cracks that propagated beyond the contact surface. The fatigue crack growth rate for P35 and E2A also increased in proportion to 1/Mn, after the molar mass was reduced below a critical value of ≈30 kg/mole. Interestingly, this critical molar mass coincided with that at which the single cycle stress-strain response changed from strain hardening to strain softening. The changes in both abrasion and fatigue resistance, key predictors for long term reliability of cardiac leads, after exposure of this class of PDMS-urethanes to water suggests that these materials are susceptible to mechanical compromise in vivo. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

KSC-03PD-2139

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, STS-115 Mission Specialists Joseph Tanner (center) and Heidemarie Stefanyshyn-Piper (right) look at the inside of the Japanese Experiment Module (JEM) Pressurized Module. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-115 mission will deliver the second port truss segment, the P3/P4 Truss, to attach to the first port truss segment, the P1 Truss, as well as deploy solar array sets 2A and 4A.. The crew is scheduled to activate and check out the Solar Alpha Rotary Joint (SARJ) and deploy the P4 Truss radiator.

KSC-03PD-2138

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, STS-115 Mission Specialists Joseph Tanner (left) and Heidemarie Stefanyshyn-Piper (right) look over the Japanese Experiment Module (JEM) Pressurized Module located in the Space Station Processing Facility. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-115 mission will deliver the second port truss segment, the P3/P4 Truss, to attach to the first port truss segment, the P1 Truss, as well as deploy solar array sets 2A and 4A.. The crew is scheduled to activate and check out the Solar Alpha Rotary Joint (SARJ) and deploy the P4 Truss radiator.

KSC-03PD-2141

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, STS-115 Mission Specialist Heidemarie Stefanyshyn-Piper (left) gets ready to check out the Japanese Experiment Module (JEM) Pressurized Module. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-115 mission will deliver the second port truss segment, the P3/P4 Truss, to attach to the first port truss segment, the P1 Truss, as well as deploy solar array sets 2A and 4A.. The crew is scheduled to activate and check out the Solar Alpha Rotary Joint (SARJ) and deploy the P4 Truss radiator.

KSC-03PD-2140

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, STS-115 Mission Specialists Heidemarie Stefanyshyn- Piper (left) and Joseph Tanner (center) get ready to check out the Japanese Experiment Module (JEM) Pressurized Module. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-115 mission will deliver the second port truss segment, the P3/P4 Truss, to attach to the first port truss segment, the P1 Truss, as well as deploy solar array sets 2A and 4A.. The crew is scheduled to activate and check out the Solar Alpha Rotary Joint (SARJ) and deploy the P4 Truss radiator.

Influence of meteorological conditions on hospital admission in patients with acute coronary syndrome with and without ST-segment elevation: Results of the AIRACOS study.

PubMed

Dominguez-Rodriguez, A; Juarez-Prera, R A; Rodríguez, S; Abreu-Gonzalez, P; Avanzas, P

2016-05-01

Evaluate whether the meterological parameters affecting revenues in patients with ST-segment and non-ST-segment elevation ACS. A prospective cohort study was carried out. Coronary Care Unit of Hospital Universitario de Canarias We studies a total of 307 consecutive patients with a diagnosis of ST-segment and non-ST-segment elevation ACS. We analyze the average concentrations of particulate smaller than 10 and 2.5μm diameter, particulate black carbon, the concentrations of gaseous pollutants and meteorological parameters (wind speed, temperature, relative humidity and atmospheric pressure) that were exposed patients from one day up to 7 days prior to admission. None. Demographic, clinical, atmospheric particles, concentrations of gaseous pollutants and meterological parameters. A total of 138 (45%) patients were classified as ST-segment and 169 (55%) as non-ST-segment elevation ACS. No statistically significant differences in exposure to atmospheric particles in both groups. Regarding meteorological data, we did not find statistically significant differences, except for higher atmospheric pressure in ST-segment elevation ACS (999.6±2.6 vs. 998.8±2.5 mbar, P=.008). Multivariate analysis showed that atmospheric pressure was significant predictor of ST-segment elevation ACS presentation (OR: 1.14, 95% CI: 1.04-1.24, P=.004). In the patients who suffer ACS, the presence of higher number of atmospheric pressure during the week before the event increase the risk that the ST-segment elevation ACS. Copyright © 2015 Elsevier España, S.L.U. and SEMICYUC. All rights reserved.

Off- and Along-Axis Slow Spreading Ridge Segment Characters: Insights From 3d Thermal Modeling

NASA Astrophysics Data System (ADS)

Gac, S.; Tisseau, C.; Dyment, J.

2001-12-01

Many observations along the Mid-Atlantic Ridge segments suggest a correlation between surface characters (length, axial morphology) and the thermal state of the segment. Thibaud et al. (1998) classify segments according to their thermal state: "colder" segments shorter than 30 km show a weak magmatic activity, and "hotter" segments as long as 90 km show a robust magmatic activity. The existence of such a correlation suggests that the thermal structure of a slow spreading ridge segment explains most of the surface observations. Here we test the physical coherence of such an integrated thermal model and evaluate it quantitatively. The different kinds of segment would constitute different phases in a segment evolution, the segment evolving progressively from a "colder" to a "hotter" so to a "colder" state. Here we test the consistency of such an evolution scheme. To test these hypotheses we have developed a 3D numerical model for the thermal structure and evolution of a slow spreading ridge segment. The thermal structure is controlled by the geometry and the dimensions of a permanently hot zone, imposed beneath the segment center, where is simulated the adiabatic ascent of magmatic material. To compare the model with the observations several geophysic quantities which depend on the thermal state are simulated: crustal thickness variations along axis, gravity anomalies (reflecting density variations) and earthquake maximum depth (corresponding to the 750° C isotherm depth). The thermal structure of a particular segment is constrained by comparing the simulated quantities to the real ones. Considering realistic magnetization parameters, the magnetic anomalies generated from the same thermal structure and evolution reproduce the observed magnetic anomaly amplitude variations along the segment. The thermal structures accounting for observations are determined for each kind of segment (from "colder" to "hotter"). The evolution of the thermal structure from the "colder" to the "hotter" segments gives credence to a temporal relationship between the different kinds of segment. The resulting thermal evolution model of slow spreading ridge segments may explain the rhomboedric shapes observed off-axis.

Measurement of aspheric mirror segments using Fizeau interferometry with CGH correction

NASA Astrophysics Data System (ADS)

Burge, James H.; Zhao, Chunyu; Dubin, Matt

2010-07-01

Large aspheric primary mirrors are proposed that use hundreds segments that all must be aligned and phased to approximate the desired continuous mirror. We present a method of measuring these concave segments with a Fizeau interferometer where a spherical convex reference surface is held a few millimeters from the aspheric segment. The aspheric shape is accommodated by a small computer generated hologram (CGH). Different segments are measured by replacing the CGH. As a Fizeau test, nearly all of the optical elements and air spaces are common to both the measurement and reference wavefront, so the sensitivities are not tight. Also, since the reference surface of the test plate is common to all tests, this system achieves excellent control for the radius of curvature variation from one part to another. This paper describes the test system design and analysis for such a test, and presents data from a similar 1.4-m test performed at the University of Arizona.

Segmentation of the Calaveras-Hayward Fault System Based on 3-D Geometry and Geology at Large-Earthquake Depth

NASA Astrophysics Data System (ADS)

Graymer, R. W.; Simpson, R. W.; Jachens, R. C.; Ponce, D. A.; Phelps, G. A.; Watt, J. T.; Wentworth, C. M.

2007-12-01

For the purpose of estimating seismic hazard, the Calaveras and Hayward Faults have been considered as separate structures and analyzed and segmented based largely on their surface-trace geometry and the extent of the 1868 Hayward Fault earthquake. Recent relocations of earthquakes and 3-D geologic mapping have shown, however, that at depths associated with large earthquakes (>5 km) the fault geology and geometry is quite different than that at the surface. Using deep fault geometry inferred from these studies we treat the Hayward and Calaveras Faults as a single system and divide the system into segments that differ from the previously accepted segments as follows: 1. The Hayward Fault connects directly to the central Calaveras Fault at depth, as opposed to the 5 km wide restraining stepover zone of multiple imbricate oblique right-lateral reverse faults at the surface east of Fremont and San Jose (between about 37.25°-37.6°N). 2. The segment boundary between the Hayward, central Calaveras, and northern Calaveras is based on their Y- shaped intersection at depth near 37.40°N, 121.76°W (Cherry Flat Reservoir), about 8 km south of the previously accepted central-northern Calaveras Fault segment boundary. 3. The central Calaveras Fault is divided near 37.14°N, 121.56°W (southern end of Anderson Lake) into two subsegments based on a large discontinuity at depth seen in relocated seismicity. 4. The Hayward Fault is divided near 37.85°N, 122.23°W (Lake Temescal) into two segments based on a large contrast in fault face geology. This segmentation is similar to that based on the extent of 1868 fault rupture, but is now related to an underlying geologic cause. The direct connection of the Hayward and central Calaveras Faults at depth suggests that earthquakes larger than those previously modeled should be considered (~M6.9 for the southern Hayward, ~M7.2 for the southern Hayward plus northern central Calaveras). A NEHRP study by Witter and others (2003; NEHRP 03HQGR0098) suggested evidence for large surface ruptures on the northern central Calaveras, but that work is not peer-reviewed and there is little or no other paleoseismic or geodetic data from the stepover zone or northern central Calaveras Fault (all commonly cited data are from the southern central Calaveras Fault), so the sparse surface data neither demands nor precludes our interpretation. The additional segmentation of the central Calaveras Fault proposed here may explain the observation that this segment seems to generate characteristic moderate (~M6.0-6.5) earthquakes rather than the larger ~M6.9 earthquakes that could be generated by rupture of the previously defined longer central Calaveras segment. Better information regarding fault plane geometry and 3-D distribution of rock properties adjacent to the faults at seismogenic depths should help us revise proposed segmentation models of other faults for seismic hazard analyses.

Toward accurate tooth segmentation from computed tomography images using a hybrid level set model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gan, Yangzhou; Zhao, Qunfei; Xia, Zeyang, E-mail: zy.xia@siat.ac.cn, E-mail: jing.xiong@siat.ac.cn

Purpose: A three-dimensional (3D) model of the teeth provides important information for orthodontic diagnosis and treatment planning. Tooth segmentation is an essential step in generating the 3D digital model from computed tomography (CT) images. The aim of this study is to develop an accurate and efficient tooth segmentation method from CT images. Methods: The 3D dental CT volumetric images are segmented slice by slice in a two-dimensional (2D) transverse plane. The 2D segmentation is composed of a manual initialization step and an automatic slice by slice segmentation step. In the manual initialization step, the user manually picks a starting slicemore » and selects a seed point for each tooth in this slice. In the automatic slice segmentation step, a developed hybrid level set model is applied to segment tooth contours from each slice. Tooth contour propagation strategy is employed to initialize the level set function automatically. Cone beam CT (CBCT) images of two subjects were used to tune the parameters. Images of 16 additional subjects were used to validate the performance of the method. Volume overlap metrics and surface distance metrics were adopted to assess the segmentation accuracy quantitatively. The volume overlap metrics were volume difference (VD, mm{sup 3}) and Dice similarity coefficient (DSC, %). The surface distance metrics were average symmetric surface distance (ASSD, mm), RMS (root mean square) symmetric surface distance (RMSSSD, mm), and maximum symmetric surface distance (MSSD, mm). Computation time was recorded to assess the efficiency. The performance of the proposed method has been compared with two state-of-the-art methods. Results: For the tested CBCT images, the VD, DSC, ASSD, RMSSSD, and MSSD for the incisor were 38.16 ± 12.94 mm{sup 3}, 88.82 ± 2.14%, 0.29 ± 0.03 mm, 0.32 ± 0.08 mm, and 1.25 ± 0.58 mm, respectively; the VD, DSC, ASSD, RMSSSD, and MSSD for the canine were 49.12 ± 9.33 mm{sup 3}, 91.57 ± 0.82%, 0.27 ± 0.02 mm, 0.28 ± 0.03 mm, and 1.06 ± 0.40 mm, respectively; the VD, DSC, ASSD, RMSSSD, and MSSD for the premolar were 37.95 ± 10.13 mm{sup 3}, 92.45 ± 2.29%, 0.29 ± 0.06 mm, 0.33 ± 0.10 mm, and 1.28 ± 0.72 mm, respectively; the VD, DSC, ASSD, RMSSSD, and MSSD for the molar were 52.38 ± 17.27 mm{sup 3}, 94.12 ± 1.38%, 0.30 ± 0.08 mm, 0.35 ± 0.17 mm, and 1.52 ± 0.75 mm, respectively. The computation time of the proposed method for segmenting CBCT images of one subject was 7.25 ± 0.73 min. Compared with two other methods, the proposed method achieves significant improvement in terms of accuracy. Conclusions: The presented tooth segmentation method can be used to segment tooth contours from CT images accurately and efficiently.« less

System and process for detecting and monitoring surface defects

NASA Technical Reports Server (NTRS)

Mueller, Mark K. (Inventor)

1994-01-01

A system and process for detecting and monitoring defects in large surfaces such as the field joints of the container segments of a space shuttle booster motor. Beams of semi-collimated light from three non-parallel fiber optic light panels are directed at a region of the surface at non-normal angles of expected incidence. A video camera gathers some portion of the light that is reflected at an angle other than the angle of expected reflectance, and generates signals which are analyzed to discern defects in the surface. The analysis may be performed by visual inspection of an image on a video monitor, or by inspection of filtered or otherwise processed images. In one alternative embodiment, successive predetermined regions of the surface are aligned with the light source before illumination, thereby permitting efficient detection of defects in a large surface. Such alignment is performed by using a line scan gauge to sense the light which passes through an aperture in the surface. In another embodiment a digital map of the surface is created, thereby permitting the maintenance of records detailing changes in the location or size of defects as the container segment is refurbished and re-used. The defect detection apparatus may also be advantageously mounted on a fixture which engages the edge of a container segment.

Segmentation of pulmonary nodules in three-dimensional CT images by use of a spiral-scanning technique

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang Jiahui; Engelmann, Roger; Li Qiang

2007-12-15

Accurate segmentation of pulmonary nodules in computed tomography (CT) is an important and difficult task for computer-aided diagnosis of lung cancer. Therefore, the authors developed a novel automated method for accurate segmentation of nodules in three-dimensional (3D) CT. First, a volume of interest (VOI) was determined at the location of a nodule. To simplify nodule segmentation, the 3D VOI was transformed into a two-dimensional (2D) image by use of a key 'spiral-scanning' technique, in which a number of radial lines originating from the center of the VOI spirally scanned the VOI from the 'north pole' to the 'south pole'. Themore » voxels scanned by the radial lines provided a transformed 2D image. Because the surface of a nodule in the 3D image became a curve in the transformed 2D image, the spiral-scanning technique considerably simplified the segmentation method and enabled reliable segmentation results to be obtained. A dynamic programming technique was employed to delineate the 'optimal' outline of a nodule in the 2D image, which corresponded to the surface of the nodule in the 3D image. The optimal outline was then transformed back into 3D image space to provide the surface of the nodule. An overlap between nodule regions provided by computer and by the radiologists was employed as a performance metric for evaluating the segmentation method. The database included two Lung Imaging Database Consortium (LIDC) data sets that contained 23 and 86 CT scans, respectively, with 23 and 73 nodules that were 3 mm or larger in diameter. For the two data sets, six and four radiologists manually delineated the outlines of the nodules as reference standards in a performance evaluation for nodule segmentation. The segmentation method was trained on the first and was tested on the second LIDC data sets. The mean overlap values were 66% and 64% for the nodules in the first and second LIDC data sets, respectively, which represented a higher performance level than those of two existing segmentation methods that were also evaluated by use of the LIDC data sets. The segmentation method provided relatively reliable results for pulmonary nodule segmentation and would be useful for lung cancer quantification, detection, and diagnosis.« less

Design and fabrication of Ni nanowires having periodically hollow nanostructures.

PubMed

Sada, Takao; Fujigaya, Tsuyohiko; Nakashima, Naotoshi

2014-10-07

We propose a concept for the design and fabrication of metal nanowires having periodically hollow nanostructures inside the pores of an anodic aluminum oxide (AAO) membrane using a sacrificial metal. In this study, nickel (Ni) and silver (Ag) were used as the base metal and the sacrificial metal, respectively. Alternating an applied potential between -0.4 and -1.0 V provided alternatively deposited Ni and Ag segments in a Ni-Ag 'barcode' nanowire with a diameter of 18 or 35 nm. After etching away the Ag segments, we fabricated Ni nanowires with nanopores of 12 ± 5.3 nm. Such nanostructure formation is explained by the formation of a Ni shell layer over the surface of the Ag segments due to the strong affinity of Ni(2+) for the interior surfaces of AAO. The Ni shell layer allows the Ni segments to remain even after dissolution of the Ag segments. Because the electroplating conditions can be easily controlled, we could carefully adjust the size and pitch of the periodically hollow nanospaces. We also describe a method for the fabrication of Ni nanorods by forming an Ag shell instead of a Ni shell on the Ni-Ag barcode nanowire, in which the interior of the AAO surfaces was modified with a compound bearing a thiol group prior to electroplating.

Two methods of Haustral fold detection from computed tomographic virtual colonoscopy images

NASA Astrophysics Data System (ADS)

Chowdhury, Ananda S.; Tan, Sovira; Yao, Jianhua; Linguraru, Marius G.; Summers, Ronald M.

2009-02-01

Virtual colonoscopy (VC) has gained popularity as a new colon diagnostic method over the last decade. VC is a new, less invasive alternative to the usually practiced optical colonoscopy for colorectal polyp and cancer screening, the second major cause of cancer related deaths in industrial nations. Haustral (colonic) folds serve as important landmarks for virtual endoscopic navigation in the existing computer-aided-diagnosis (CAD) system. In this paper, we propose and compare two different methods of haustral fold detection from volumetric computed tomographic virtual colonoscopy images. The colon lumen is segmented from the input using modified region growing and fuzzy connectedness. The first method for fold detection uses a level set that evolves on a mesh representation of the colon surface. The colon surface is obtained from the segmented colon lumen using the Marching Cubes algorithm. The second method for fold detection, based on a combination of heat diffusion and fuzzy c-means algorithm, is employed on the segmented colon volume. Folds obtained on the colon volume using this method are then transferred to the corresponding colon surface. After experimentation with different datasets, results are found to be promising. The results also demonstrate that the first method has a tendency of slight under-segmentation while the second method tends to slightly over-segment the folds.

Inner and outer coronary vessel wall segmentation from CCTA using an active contour model with machine learning-based 3D voxel context-aware image force

NASA Astrophysics Data System (ADS)

Sivalingam, Udhayaraj; Wels, Michael; Rempfler, Markus; Grosskopf, Stefan; Suehling, Michael; Menze, Bjoern H.

2016-03-01

In this paper, we present a fully automated approach to coronary vessel segmentation, which involves calcification or soft plaque delineation in addition to accurate lumen delineation, from 3D Cardiac Computed Tomography Angiography data. Adequately virtualizing the coronary lumen plays a crucial role for simulating blood ow by means of fluid dynamics while additionally identifying the outer vessel wall in the case of arteriosclerosis is a prerequisite for further plaque compartment analysis. Our method is a hybrid approach complementing Active Contour Model-based segmentation with an external image force that relies on a Random Forest Regression model generated off-line. The regression model provides a strong estimate of the distance to the true vessel surface for every surface candidate point taking into account 3D wavelet-encoded contextual image features, which are aligned with the current surface hypothesis. The associated external image force is integrated in the objective function of the active contour model, such that the overall segmentation approach benefits from the advantages associated with snakes and from the ones associated with machine learning-based regression alike. This yields an integrated approach achieving competitive results on a publicly available benchmark data collection (Rotterdam segmentation challenge).

Groundwater-surfacewater relationships in the Bonaparte Creek basin, Okanogan County, Washington, 1979-1980

USGS Publications Warehouse

Packard, F.A.; Sumioka, S.S.; Whiteman, K.J.

1983-01-01

Ground water-surface-water relationships were studied in five morphological segments in the Bonaparte Creek basin, Washington during 1979 and 1980. In one segment, kettle lakes were found to be closely associated with the ground-water system. In the other four segments, a close relationship was found between streamflow and ground water. It was concluded that additional ground-water development would adversely affect lake levels and streamflow, thereby reducing surface-water resources already closed to further appropriation. The ground-water divide between the Bonaparte and Sanpoil basins was 6 miles southeast of where it was estimated to be. (USGS)

Electrode holder useful in a corrosion testing device

DOEpatents

Murphy, R.J. Jr.; Jamison, D.E.

1986-08-19

The present invention is directed to an apparatus and method for holding one or more test electrodes of precisely known exposed surface area. The present invention is particularly useful in a device for determining the corrosion properties of the materials from which the test electrodes have been formed. The present invention relates to a device and method for holding the described electrodes wherein the exposed surface area of the electrodes is only infinitesimally decreased. Further, in the present invention the exposed, electrically conductive surface area of the contact devices is small relative to the test electrode surface area. The holder of the present invention conveniently comprises a device for contacting and engaging each test electrode at two point contacts infinitesimally small in relation to the exposed surface area of the electrodes. 4 figs.

Electrode holder useful in a corrosion testing device

DOEpatents

Murphy, Jr., Robert J.; Jamison, Dale E.

1986-01-01

The present invention is directed to an apparatus and method for holding one or more test electrodes of precisely known exposed surface area. The present invention is particularly useful in a device for determining the corrosion properties of the materials from which the test electrodes have been formed. The present invention relates to a device and method for holding the described electrodes wherein the exposed surface area of the electrodes is only infinitesimally decreased. Further, in the present invention the exposed, electrically conductive surface area of the contact devices is small relative to the test electrode surface area. The holder of the present invention conveniently comprises a device for contacting and engaging each test electrode at two point contacts infinitesimally small in relation to the exposed surface area of the electrodes.

Metric Learning to Enhance Hyperspectral Image Segmentation

NASA Technical Reports Server (NTRS)

Thompson, David R.; Castano, Rebecca; Bue, Brian; Gilmore, Martha S.

2013-01-01

Unsupervised hyperspectral image segmentation can reveal spatial trends that show the physical structure of the scene to an analyst. They highlight borders and reveal areas of homogeneity and change. Segmentations are independently helpful for object recognition, and assist with automated production of symbolic maps. Additionally, a good segmentation can dramatically reduce the number of effective spectra in an image, enabling analyses that would otherwise be computationally prohibitive. Specifically, using an over-segmentation of the image instead of individual pixels can reduce noise and potentially improve the results of statistical post-analysis. In this innovation, a metric learning approach is presented to improve the performance of unsupervised hyperspectral image segmentation. The prototype demonstrations attempt a superpixel segmentation in which the image is conservatively over-segmented; that is, the single surface features may be split into multiple segments, but each individual segment, or superpixel, is ensured to have homogenous mineralogy.

Precision segmented reflector, figure verification sensor

NASA Technical Reports Server (NTRS)

Manhart, Paul K.; Macenka, Steve A.

1989-01-01

The Precision Segmented Reflector (PSR) program currently under way at the Jet Propulsion Laboratory is a test bed and technology demonstration program designed to develop and study the structural and material technologies required for lightweight, precision segmented reflectors. A Figure Verification Sensor (FVS) which is designed to monitor the active control system of the segments is described, a best fit surface is defined, and an image or wavefront quality of the assembled array of reflecting panels is assessed

Atlas-based automatic segmentation of head and neck organs at risk and nodal target volumes: a clinical validation.

PubMed

Daisne, Jean-François; Blumhofer, Andreas

2013-06-26

Intensity modulated radiotherapy for head and neck cancer necessitates accurate definition of organs at risk (OAR) and clinical target volumes (CTV). This crucial step is time consuming and prone to inter- and intra-observer variations. Automatic segmentation by atlas deformable registration may help to reduce time and variations. We aim to test a new commercial atlas algorithm for automatic segmentation of OAR and CTV in both ideal and clinical conditions. The updated Brainlab automatic head and neck atlas segmentation was tested on 20 patients: 10 cN0-stages (ideal population) and 10 unselected N-stages (clinical population). Following manual delineation of OAR and CTV, automatic segmentation of the same set of structures was performed and afterwards manually corrected. Dice Similarity Coefficient (DSC), Average Surface Distance (ASD) and Maximal Surface Distance (MSD) were calculated for "manual to automatic" and "manual to corrected" volumes comparisons. In both groups, automatic segmentation saved about 40% of the corresponding manual segmentation time. This effect was more pronounced for OAR than for CTV. The edition of the automatically obtained contours significantly improved DSC, ASD and MSD. Large distortions of normal anatomy or lack of iodine contrast were the limiting factors. The updated Brainlab atlas-based automatic segmentation tool for head and neck Cancer patients is timesaving but still necessitates review and corrections by an expert.

A Fast Method for the Segmentation of Synaptic Junctions and Mitochondria in Serial Electron Microscopic Images of the Brain.

PubMed

Márquez Neila, Pablo; Baumela, Luis; González-Soriano, Juncal; Rodríguez, Jose-Rodrigo; DeFelipe, Javier; Merchán-Pérez, Ángel

2016-04-01

Recent electron microscopy (EM) imaging techniques permit the automatic acquisition of a large number of serial sections from brain samples. Manual segmentation of these images is tedious, time-consuming and requires a high degree of user expertise. Therefore, there is considerable interest in developing automatic segmentation methods. However, currently available methods are computationally demanding in terms of computer time and memory usage, and to work properly many of them require image stacks to be isotropic, that is, voxels must have the same size in the X, Y and Z axes. We present a method that works with anisotropic voxels and that is computationally efficient allowing the segmentation of large image stacks. Our approach involves anisotropy-aware regularization via conditional random field inference and surface smoothing techniques to improve the segmentation and visualization. We have focused on the segmentation of mitochondria and synaptic junctions in EM stacks from the cerebral cortex, and have compared the results to those obtained by other methods. Our method is faster than other methods with similar segmentation results. Our image regularization procedure introduces high-level knowledge about the structure of labels. We have also reduced memory requirements with the introduction of energy optimization in overlapping partitions, which permits the regularization of very large image stacks. Finally, the surface smoothing step improves the appearance of three-dimensional renderings of the segmented volumes.

Enhancing the protein resistance of silicone via surface-restructuring PEO-silane amphiphiles with variable PEO length

PubMed Central

Rufin, M. A.; Gruetzner, J. A.; Hurley, M. J.; Hawkins, M. L.; Raymond, E. S.; Raymond, J. E.

2015-01-01

Silicones with superior protein resistance were produced by bulk-modification with poly(ethylene oxide) (PEO)-silane amphiphiles that demonstrated a higher capacity to restructure to the surface-water interface versus conventional non-amphiphilic PEO-silanes. The PEO-silane amphiphiles were prepared with a single siloxane tether length but variable PEO segment lengths: α-(EtO)3Si(CH2)2-oligodimethylsiloxane13-block-poly(ethylene oxide)n-OCH3 (n = 3, 8, and 16). Conventional PEO-silane analogues (n = 3, 8 and 16) as well as a siloxane tether-silane (i.e. no PEO segment) were prepared as controls. When surface-grafted onto silicon wafer, PEO-silane amphiphiles produced surfaces that were more hydrophobic and thus more adherent towards fibrinogen versus the corresponding PEO-silane. However, when blended into a silicone, PEO-silane amphiphiles exhibited rapid restructuring to the surface-water interface and excellent protein resistance whereas the PEO-silanes did not. Silicones modified with PEO-silane amphiphiles of PEO segment lengths n = 8 and 16 achieved the highest protein resistance. PMID:26339488

Atomistic insight into the adsorption site selectivity of stepped Au(111) surfaces

NASA Astrophysics Data System (ADS)

Gaspari, Roberto; Pignedoli, Carlo A.; Fasel, Roman; Treier, Matthias; Passerone, Daniele

2010-07-01

Using classical and ab initio simulations, we study the interplay between the Au(111) surface reconstruction and monoatomic steps on a vicinal face. The experimentally observed discommensuration line patterns on a specific vicinal are reproduced and explained, and a complete description of the structure is given. An unusual atomic arrangement is shown to be responsible for the lower reactivity of hcp segments of step edges compared to the one of fcc segments. Our results provide an unprecedented understanding of the electronic and geometric properties of the complex Au(111) surface.

Metric Learning for Hyperspectral Image Segmentation

NASA Technical Reports Server (NTRS)

Bue, Brian D.; Thompson, David R.; Gilmore, Martha S.; Castano, Rebecca

2011-01-01

We present a metric learning approach to improve the performance of unsupervised hyperspectral image segmentation. Unsupervised spatial segmentation can assist both user visualization and automatic recognition of surface features. Analysts can use spatially-continuous segments to decrease noise levels and/or localize feature boundaries. However, existing segmentation methods use tasks-agnostic measures of similarity. Here we learn task-specific similarity measures from training data, improving segment fidelity to classes of interest. Multiclass Linear Discriminate Analysis produces a linear transform that optimally separates a labeled set of training classes. The defines a distance metric that generalized to a new scenes, enabling graph-based segmentation that emphasizes key spectral features. We describe tests based on data from the Compact Reconnaissance Imaging Spectrometer (CRISM) in which learned metrics improve segment homogeneity with respect to mineralogical classes.

Automatic segmentation of the facial nerve and chorda tympani using image registration and statistical priors

NASA Astrophysics Data System (ADS)

Noble, Jack H.; Warren, Frank M.; Labadie, Robert F.; Dawant, Benoit M.

2008-03-01

In cochlear implant surgery, an electrode array is permanently implanted in the cochlea to stimulate the auditory nerve and allow deaf people to hear. A minimally invasive surgical technique has recently been proposed--percutaneous cochlear access--in which a single hole is drilled from the skull surface to the cochlea. For the method to be feasible, a safe and effective drilling trajectory must be determined using a pre-operative CT. Segmentation of the structures of the ear would improve trajectory planning safety and efficiency and enable the possibility of automated planning. Two important structures of the ear, the facial nerve and chorda tympani, present difficulties in intensity based segmentation due to their diameter (as small as 1.0 and 0.4 mm) and adjacent inter-patient variable structures of similar intensity in CT imagery. A multipart, model-based segmentation algorithm is presented in this paper that accomplishes automatic segmentation of the facial nerve and chorda tympani. Segmentation results are presented for 14 test ears and are compared to manually segmented surfaces. The results show that mean error in structure wall localization is 0.2 and 0.3 mm for the facial nerve and chorda, proving the method we propose is robust and accurate.

Effects of Alternating Hydrogenated and Protonated Segments in polymers on their Wettability.

NASA Astrophysics Data System (ADS)

Smith, Dennis; Traiphol, Rakchart; Cheng, Gang; Perahia, Dvora

2003-03-01

Polymers consisting of alternating hydrogenated and fluorinated segments exhibit unique interfacial characteristics governed by the components that dominate the interface. Presence of fluorine reduces the interfacial energy and is expected to decrease the adhesion to the polymer surface. Thin liquid crystalline (LC) layers of 4,4?-octyl-cyanobiphenyl, cast on top of a polymeric layer consisting of alternating methylstylbine protonated segments bridged by a fluorinated group was used as a mechanistic tool to study of interfacial effects on three parameters: wetting, interfacial alignment and surface induces structures. The liquid crystal cast on a low interfacial energy fluorinated polymeric film exhibits bulk homeotropic alignment as expected. However it fully wetted the polymer surface despite the incompatibility of the protonated LC and mainly fluorinated polymer interface. Further more, it was found to stabilize the interfacial Semitic layers to a higher temperature and induce different surface ordering that was not observed at the same temperature neither in the bulk nor at the interfaces with silicon or glass surface. These results indicate that the interfacial interactions of polymers with liquid crystals are a complex function of both surface energies and the interfacial structure of the polymer.

MRI based knee cartilage assessment

NASA Astrophysics Data System (ADS)

Kroon, Dirk-Jan; Kowalski, Przemyslaw; Tekieli, Wojciech; Reeuwijk, Els; Saris, Daniel; Slump, Cornelis H.

2012-03-01

Osteoarthritis is one of the leading causes of pain and disability worldwide and a major health problem in developed countries due to the gradually aging population. Though the symptoms are easily recognized and described by a patient, it is difficult to assess the level of damage or loss of articular cartilage quantitatively. We present a novel method for fully automated knee cartilage thickness measurement and subsequent assessment of the knee joint. First, the point correspondence between a pre-segmented training bone model is obtained with use of Shape Context based non-rigid surface registration. Then, a single Active Shape Model (ASM) is used to segment both Femur and Tibia bone. The surfaces obtained are processed to extract the Bone-Cartilage Interface (BCI) points, where the proper segmentation of cartilage begins. For this purpose, the cartilage ASM is trained with cartilage edge positions expressed in 1D coordinates at the normals in the BCI points. The whole cartilage model is then constructed from the segmentations obtained in the previous step. An absolute thickness of the segmented cartilage is measured and compared to the mean of all training datasets, giving as a result the relative thickness value. The resulting cartilage structure is visualized and related to the segmented bone. In this way the condition of the cartilage is assessed over the surface. The quality of bone and cartilage segmentation is validated and the Dice's coefficients 0.92 and 0.86 for Femur and Tibia bones and 0.45 and 0.34 for respective cartilages are obtained. The clinical diagnostic relevance of the obtained thickness mapping is being evaluated retrospectively. We hope to validate it prospectively for prediction of clinical outcome the methods require improvements in accuracy and robustness.

Geometry, slip distribution, and kinematics of surface rupture on the Sakarya fault segment during the 17 August 1999 İzmit, Turkey, earthquake

USGS Publications Warehouse

Langridge, R.M.; Stenner, Heidi D.; Fumal, T.E.; Christofferson, S.A.; Rockwell, T.K.; Hartleb, R.D.; Bachhuber, J.; Barka, A.A.

2002-01-01

The Mw 7.4 17 August 1999 İzmit earthquake ruptured five major fault segments of the dextral North Anatolian Fault Zone. The 26-km-long, N86°W-trending Sakarya fault segment (SFS) extends from the Sapanca releasing step-over in the west to near the town of Akyazi in the east. The SFS emerges from Lake Sapanca as two distinct fault traces that rejoin to traverse the Adapazari Plain to Akyazi. Offsets were measured across 88 cultural and natural features that cross the fault, such as roads, cornfield rows, rows of trees, walls, rails, field margins, ditches, vehicle ruts, a dike, and ground cracks. The maximum displacement observed for the İzmit earthquake (∼5.1 m) was encountered on this segment. Dextral displacement for the SFS rises from less than 1 m at Lake Sapanca to greater than 5 m near Arifiye, only 3 km away. Average slip decreases uniformly to the east from Arifiye until the fault steps left from Sagir to Kazanci to the N75°W, 6-km-long Akyazi strand, where slip drops to less than 1 m. The Akyazi strand passes eastward into the Akyazi Bend, which consists of a high-angle bend (18°-29°) between the Sakarya and Karadere fault segments, a 6-km gap in surface rupture, and high aftershock energy release. Complex structural geometries exist between the İzmit, Düzce, and 1967 Mudurnu fault segments that have arrested surface ruptures on timescales ranging from 30 sec to 88 days to 32 yr. The largest of these step-overs may have acted as a rupture segmentation boundary in previous earthquake cycles.

Surface Rupture Characteristics and Rupture Mechanics of the Yushu Earthquake (Ms7.1), 14/04/2010

NASA Astrophysics Data System (ADS)

Pan, J.; Li, H.; Xu, Z.; Li, N.; Wu, F.; Guo, R.; Zhang, W.

2010-12-01

On April 14th 2010, a disastrous earthquake (Ms 7.1) struck Yushu County, Qinghai Province, China, killing thousands of people. This earthquake occurred as a result of sinistral strike-slip faulting on the western segment of the Xianshuihe Fault zone in eastern Tibetan Plateau. Our group conducted scientific investigation in the field on co-seismic surface rupture and active tectonics in the epicenter area immediately after the earthquake. Here, we introduce our preliminary results on the surface ruptures and rupture mechanics of the Yushu Earthquake. The surface rupture zone of Yushu earthquake, which is about 49 km-long, consists of 3 discontinuous left stepping rupture segments, which are 19 km, 22 km, and about 8 km, respectively, from west to east. Each segment consists of a series of right stepping en-echelon branch ruptures. The branch ruptures consist of interphase push-up and tension fissures or simply en-echelon tension fissures. The co-seismic displacements had been surveyed with a total station in detail on landmarks such as rivers, gullies, roads, farmlands, wire poles, and fences. The maximum offset measured is 2.3m, located near the Guoyangyansongduo Village. There are 3 offset peaks along the rupture zone corresponding to the 3 segments of the surface rupture zone. The maximum offsets in the west, central, and east segment rupture zones are 1.4m, 2.3m, and 1.6m respectively. The surface rupture zone of Yushu earthquake strikes in a 310°NW direction. The fault plane dips to the northeast and the dip angle is about 81°. The rupture zone is developed in transtension setting. Tension normal fault developed during the sinistral strike-slip process of the fault. The valley west of Yushu City and the Longbao Lake are both pull-apart basins formed during the transtension activity of the fault.

Active surface model improvement by energy function optimization for 3D segmentation.

PubMed

Azimifar, Zohreh; Mohaddesi, Mahsa

2015-04-01

This paper proposes an optimized and efficient active surface model by improving the energy functions, searching method, neighborhood definition and resampling criterion. Extracting an accurate surface of the desired object from a number of 3D images using active surface and deformable models plays an important role in computer vision especially medical image processing. Different powerful segmentation algorithms have been suggested to address the limitations associated with the model initialization, poor convergence to surface concavities and slow convergence rate. This paper proposes a method to improve one of the strongest and recent segmentation algorithms, namely the Decoupled Active Surface (DAS) method. We consider a gradient of wavelet edge extracted image and local phase coherence as external energy to extract more information from images and we use curvature integral as internal energy to focus on high curvature region extraction. Similarly, we use resampling of points and a line search for point selection to improve the accuracy of the algorithm. We further employ an estimation of the desired object as an initialization for the active surface model. A number of tests and experiments have been done and the results show the improvements with regards to the extracted surface accuracy and computational time of the presented algorithm compared with the best and recent active surface models. Copyright © 2015 Elsevier Ltd. All rights reserved.

Support mechanism for a mirrored surface or other arrangement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cutburth, R.W.

1987-02-03

A mechanism is described for supporting first means including a planer surface for movement relative to a vertical plane defined by particular intersecting x and y axes which extend horizontally and vertically, respectively, the mechanism comprising: (a) second means including a plurality of segments of an annular surface which forms part of a sphere whose center defines the intersection of the x and y axes. The annular surface defines a z axis extending through the intersection of the x and y axes perpendicular to the vertical plane; (b) third means connecting the planer surface including first means with the secondmore » means such that the planer surface is positionably within the vertical plane and is itself intersected by the z axis at a particular point thereon. The third means includes bearing means disposed between the first means and the segments of the annular surface of the second means for allowing the first means to move in any direction on the annular surface segments including certain specific directions which allow the planer surface to pivot back and forth to a limited extent about both the x and y axes relative to the vertical plane; and (c) fourth means interconnecting the first and second means and cooperating with the third means for limiting the movement of the first means to the certain specific directions.« less

Effects of the low Earth orbit space environment on the surface chemistry of Kapton polyimide film: An XPS study

NASA Technical Reports Server (NTRS)

Lee, Myung; Rooney, William; Whiteside, James

1992-01-01

Kapton H (DuPont Trademark) polyimide specimens exposed to the low earth (LEO) space environment suffered significant weathering with surface erosions of approximately 8.0 microns. Despite these effects, no significant changes in bulk chemistry were observed. X-ray photoelectron spectroscopy (XPS) was used to determine local changes induced from approximately 25 percent in 1980 vintage ground control specimens to nearly 53 percent in space exposed specimens. The greatest increase was observed for the divalent oxygen moieties, although a slight increase in carbonyl oxygen was also measured. Furthermore, the chemical shifts of all XPS peaks of space-exposed Kapton are shifted to higher energy. This is consistent with a higher oxidation state of the space exposed surface. Finally, space exposed specimens had distinct silicon peaks (2p 100 eV and 2s 149 eV) in their XPS spectra in agreement with widespread reports of silicon contamination throughout the LDEF satellite. These results are discussed in terms of surface reactivity of the polyimide exposed to the LEO environment and the chemical nature of contaminants deposited on flight surfaces due to satellite outgassing.

Cesic: manufacturing study for next generation telescopes

NASA Astrophysics Data System (ADS)

Kroedel, M.; Lichtscheindl, J.; Mair, Hp.

2005-08-01

Under ESO - European Southern Observatory - contract ECM has performed a feasibility study for the manufacturing of Cesic primary and secondary mirror segments for the OWL-Telescope. The main issues of this study were to demonstrate the feasibility of the serial production (~ 2550 segments) of Cesic mirror segments under a certain schedule and cost optimisation aspect for the segments. Part of this study was also a pre-design of a manufacturing facility for this big amount of mirror segments. This study is limited only up to the manufacturing of a polishable surface, the feasibility of the polishing capability is not part of this study.

DICHLOROACETIC ACID (DCA) INHIBITS PROLIFERATION AND APOPTOSIS IN NORMAL HEPATOCYTES OF MALE F344 RATS

EPA Science Inventory

Dichloroacetic acid (DCA} inhibits proliferation and apoptosis in nonnal hepatocytes of
male F344 rats.

Large segments of the population are chronically exposed to dichloroacetic acid (DCA}: DCA is a by product of the chlorine disinfection of drinking water, a metab...

The Effects of Family and Community Violence Exposure among Youth: Recommendations for Practice and Policy

ERIC Educational Resources Information Center

Voisin, Dexter R.

2007-01-01

Compared with other segments of the population, adolescents and, in particular, African Americans are disproportionately exposed to family and community violence. Research has consistently documented that exposure to such violence is often associated with psychological difficulties, poor educational and behavioral outcomes, and juvenile justice…

Fifty Years of Predictive Testing for Human Developmental Toxicity: From Thalidomide to Virtual Embryos

EPA Science Inventory

The thalidomide tragedy of the early 1960s led to the three “Segment” tests promulgated by the United States Food and Drug Administration in 1966. The Segment II study involves exposing pregnant rodents or rabbits during organogenesis and examining fetuses prior to pa...

Automated breast segmentation in ultrasound computer tomography SAFT images

NASA Astrophysics Data System (ADS)

Hopp, T.; You, W.; Zapf, M.; Tan, W. Y.; Gemmeke, H.; Ruiter, N. V.

2017-03-01

Ultrasound Computer Tomography (USCT) is a promising new imaging system for breast cancer diagnosis. An essential step before further processing is to remove the water background from the reconstructed images. In this paper we present a fully-automated image segmentation method based on three-dimensional active contours. The active contour method is extended by applying gradient vector flow and encoding the USCT aperture characteristics as additional weighting terms. A surface detection algorithm based on a ray model is developed to initialize the active contour, which is iteratively deformed to capture the breast outline in USCT reflection images. The evaluation with synthetic data showed that the method is able to cope with noisy images, and is not influenced by the position of the breast and the presence of scattering objects within the breast. The proposed method was applied to 14 in-vivo images resulting in an average surface deviation from a manual segmentation of 2.7 mm. We conclude that automated segmentation of USCT reflection images is feasible and produces results comparable to a manual segmentation. By applying the proposed method, reproducible segmentation results can be obtained without manual interaction by an expert.

Fast Edge Detection and Segmentation of Terrestrial Laser Scans Through Normal Variation Analysis

NASA Astrophysics Data System (ADS)

Che, E.; Olsen, M. J.

2017-09-01

Terrestrial Laser Scanning (TLS) utilizes light detection and ranging (lidar) to effectively and efficiently acquire point cloud data for a wide variety of applications. Segmentation is a common procedure of post-processing to group the point cloud into a number of clusters to simplify the data for the sequential modelling and analysis needed for most applications. This paper presents a novel method to rapidly segment TLS data based on edge detection and region growing. First, by computing the projected incidence angles and performing the normal variation analysis, the silhouette edges and intersection edges are separated from the smooth surfaces. Then a modified region growing algorithm groups the points lying on the same smooth surface. The proposed method efficiently exploits the gridded scan pattern utilized during acquisition of TLS data from most sensors and takes advantage of parallel programming to process approximately 1 million points per second. Moreover, the proposed segmentation does not require estimation of the normal at each point, which limits the errors in normal estimation propagating to segmentation. Both an indoor and outdoor scene are used for an experiment to demonstrate and discuss the effectiveness and robustness of the proposed segmentation method.

Rupture of the Pitáycachi Fault in the 1887 Mw 7.5 Sonora, Mexico earthquake (southern Basin-and-Range Province): Rupture kinematics and epicenter inferred from rupture branching patterns

NASA Astrophysics Data System (ADS)

Suter, Max

2015-01-01

During the 3 May 1887 Mw 7.5 Sonora earthquake (surface rupture end-to-end length: 101.8 km), an array of three north-south striking Basin-and-Range Province faults (from north to south Pitáycachi, Teras, and Otates) slipped sequentially along the western margin of the Sierra Madre Occidental Plateau. This detailed field survey of the 1887 earthquake rupture zone along the Pitáycachi fault includes mapping the rupture scarp and measurements of surface deformation. The surface rupture has an endpoint-to-endpoint length of ≥41.0 km, dips 70°W, and is characterized by normal left-lateral extension. The maximum surface offset is 487 cm and the mean offset 260 cm. The rupture trace shows a complex pattern of second-order segmentation. However, this segmentation is not expressed in the 1887 along-rupture surface offset profile, which indicates that the secondary segments are linked at depth into a single coherent fault surface. The Pitáycachi surface rupture shows a well-developed bipolar branching pattern suggesting that the rupture originated in its central part, where the polarity of the rupture bifurcations changes. Most likely the rupture first propagated bilaterally along the Pitáycachi fault. The southern rupture front likely jumped across a step over to the Teras fault and from there across a major relay zone to the Otates fault. Branching probably resulted from the lateral propagation of the rupture after breaching the seismogenic part of the crust, given that the much shorter ruptures of the Otates and Teras segments did not develop branches.

Surface structural conformations of fibrinogen polypeptides for improved biocompatibility.

PubMed

Yaseen, Mohammed; Zhao, Xiubo; Freund, Amy; Seifalian, Alexander M; Lu, Jian R

2010-05-01

This work reports on how incorporation of silica nanocages into poly(urethane) copolymers (PU) affects conformational orientations of adsorbed fibrinogen and how different surfaces subsequently influenced HeLa cell attachment and proliferation. Incorporation of 2 wt% silica nanocages into poly(urethane) (PU4) substantially altered the surface topography of the films and some 50% of the surface was covered with the nanocages due to their preferential exposure. AFM studies revealed the deposition of a dense protein network on the soft polymeric domains of PU4 and much reduced fibrinogen adsorption on the hard nanocage domains. As on the bare SiO(2) control surface, fibrinogen molecules adsorbed on top of the hard nanocages mainly took the dominant trinodular structures in monomeric and dimeric forms. In addition, net positively charged long alpha chains were prone to being hidden beneath the D domains whilst gamma chains predominantly remained exposed. Dynamic interfacial adsorption as probed by spectroscopic ellipsometry revealed fast changes in interfacial conformation induced by electrostatic interactions between different segments of fibrinogen and the surface, consistent with the AFM imaging. On the PU surfaces without nanocage incorporation (PUA), however, adsorbed fibrinogen molecules formed beads-like chain networks, consistent with the structure featured on the soft PU4 domains, showing very different effects of surface chemical nature. Monoclonal antibodies specific to the alpha and gamma chains showed reduced alpha but increased gamma chain binding at the silicon oxide control and PU4 surfaces, whilst on the PUA, C18 and amine surfaces (organic surface controls) the opposite binding trend was detected with alpha chain binding dominant, showing different fibrinogen conformations. Cell attachment studies revealed differences in cell attachment and proliferation, consistent with the different polypeptide conformations on the two types of surfaces, showing a strong preference to the extent of exposure of gamma chains. Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved.

Engineering single-polymer micelle shape using nonuniform spontaneous surface curvature

NASA Astrophysics Data System (ADS)

Moths, Brian; Witten, T. A.

2018-03-01

Conventional micelles, composed of simple amphiphiles, exhibit only a few standard morphologies, each characterized by its mean surface curvature set by the amphiphiles. Here we demonstrate a rational design scheme to construct micelles of more general shape from polymeric amphiphiles. We replace the many amphiphiles of a conventional micelle by a single flexible, linear, block copolymer chain containing two incompatible species arranged in multiple alternating segments. With suitable segment lengths, the chain exhibits a condensed spherical configuration in solution, similar to conventional micelles. Our design scheme posits that further shapes are attained by altering the segment lengths. As a first study of the power of this scheme, we demonstrate the capacity to produce long-lived micelles of horseshoe form using conventional bead-spring simulations in two dimensions. Modest changes in the segment lengths produce smooth changes in the micelle's shape and stability.

Surface contamination on LDEF exposed materials

NASA Technical Reports Server (NTRS)

Hemminger, Carol S.

1992-01-01

X-ray photoelectron spectroscopy (XPS) has been used to study the surface composition and chemistry of Long Duration Exposure Facility (LDEF) exposed materials including silvered Teflon (Ag/FEP), Kapton, S13GLO paint, quartz crystal monitors (QCM's), carbon fiber/organic matrix composites, and carbon fiber/Al Alloy composites. In each set of samples, silicones were the major contributors to the molecular film accumulated on the LDEF exposed surfaces. All surfaces analyzed have been contaminated with Si, O, and C; most have low levels (less than 1 atom percent) of N, S, and F. Occasionally observed contaminants included Cl, Na, K, P, and various metals. Orange/brown discoloration observed near vent slots in some Ag/FEP blankets were higher in carbon, sulfur, and nitrogen relative to other contamination types. The source of contamination has not been identified, but amine/amide functionalities were detected. It is probable that this same source of contamination account for the low levels of sulfur and nitrogen observed on most LDEF exposed surfaces. XPS, which probes 50 to 100 A in depth, detected the major sample components underneath the contaminant film in every analysis. This probably indicates that the contaminant overlayer is patchy, with significant areas covered by less that 100 A of molecular film. Energy dispersive x-ray spectroscopy (EDS) of LDEF exposed surfaces during secondary electron microscopy (SEM) of the samples confirmed contamination of the surfaces with Si and O. In general, particulates were not observed to develop from the contaminant overlayer on the exposed LDEF material surfaces. However, many SiO2 submicron particles were seen on a masked edge of an Ag/FEP blanket. In some cases such as the carbon fiber/organic matrix composites, interpretation of the contamination data was hindered by the lack of good laboratory controls. Examination of laboratory controls for the carbon fiber/Al alloy composites showed that preflight contamination was the most significant factor for all the contaminants generally detected at less than 1 atom percent, or detected only occasionally (i.e., all but Si, O, and C). Flight control surfaces, including sample backsides not exposed to space radiation or atomic oxygen flux, have accumulated some contamination on flight (compared to laboratory controls), but experimentally, the LDEF exposed surface contamination levels are generally higher for the contaminants Si and O. For most materials analyzed, Si contamination levels were higher on the leading edge surfaces than on the trailing edge surfaces. This was true even for the composite samples where considerable atomic oxygen erosion of the leading edge surfaces was observed by SEM. It is probable that the return flux associated with atmospheric backscatter resulted in enhanced deposition of silicones and other contaminants on the leading edge flight surfaces relative to the trailing edge. Although the Si concentration data suggested greater on-flight deposition of contaminants on the leading edge surfaces, the XPS analyses did not conclusively show different relative total thicknesses of flight deposited contamination for leading and trailing edge surfaces. It is possible that atomic oxygen reactions on the leading edge resulted in greater volatilization of the carbon component of the deposited silicones, effectively 'thinning' the leading edge deposited overlayer. Unlike other materials, exposed polymers such as Kapton and FEP-type Teflon had very low contamination on the leading edge surfaces. SEM evidence showed that undercutting of the contaminant overlayer and damaged polymer layers occurred during atomic oxygen erosion, which would enhance loss of material from the exposed surface.

Segmented instrumentation tube including a locking sleeve for interlocking the segments of the instrumentation tube

DOEpatents

Obermeyer, F.D.

1993-11-16

Segmented instrumentation tube including a locking sleeve for interlocking the segments of the instrumentation tube, so that the threaded ends of the instrumentation tube do not unthread when subjected to vibration, such an instrumentation tube being suitable for use in a nuclear reactor pressure vessel. The instrumentation tube has a first member having a threaded end portion that has a plurality of first holes circumferentially around the outside surface thereof. The instrumentation tube also has a second member having a threaded end portion that has a plurality of second holes circumferentially around the outside surface thereof. The threads of the second member are caused to threadably engage the threads of the first member for defining a threaded joint there between. A sleeve having an inside surface surrounds the end portion of the first member and the end portion of the second member and thus surrounds the threaded joint. The sleeve includes a plurality of first projections and second projections that outwardly extend from the inside surface to engage the first holes and the second holes, respectively. The outside surface of the sleeve is crimped or swaged at the locations of the first projections and second projections such that the first projections and the second projections engage their respective holes. In this manner, independent rotation of the first member with respect to the second member is prevented, so that the instrumentation tube will not unthread at its threaded joint. 10 figures.

Segmented instrumentation tube including a locking sleeve for interlocking the segments of the instrumentation tube

DOEpatents

Obermeyer, Franklin D.

1993-01-01

Segmented instrumentation tube including a locking sleeve for interlocking the segments of the instrumentation tube, so that the threaded ends of the instrumentation tube do not unthread when subjected to vibration, such an instrumentation tube being suitable for use in a nuclear reactor pressure vessel. The instrumentation tube has a first member having a threaded end portion that has a plurality of first holes circumferentially around the outside surface thereof. The instrumentation tube also has a second member having a threaded end portion that has a plurality of second holes circumferentially around the outside surface thereof. The threads of the second member are caused to threadably engage the threads of the first member for defining a threaded joint therebetween. A sleeve having an inside surface surrounds the end portion of the first member and the end portion of the second member and thus surrounds the threaded joint. The sleeve includes a plurality of first projections and second projections that outwardly extend from the inside surface to engage the first holes and the second holes, respectively. The outside surface of the sleeve is crimped or swaged at the locations of the first projections and second projections such that the first projections and the second projections engage their respective holes. In this manner, independent rotation of the first member with respect to the second member is prevented, so that the instrumentation tube will not unthread at its threaded joint.

Shallow seismic imaging of folds above the Puente Hills blind-thrust fault, Los Angeles, California

USGS Publications Warehouse

Pratt, T.L.; Shaw, J.H.; Dolan, J.F.; Christofferson, S.A.; Williams, R.A.; Odum, J.K.; Plesch, A.

2002-01-01

High-resolution seismic reflection profiles image discrete folds in the shallow subsurface (<600 m) above two segments of the Puente Hills blind-thrust fault system, Los Angeles basin, California. The profiles demonstrate late Quaternary activity at the fault tip, precisely locate the axial surfaces of folds within the upper 100 m, and constrain the geometry and kinematics of recent folding. The Santa Fe Springs segment of the Puente Hills fault zone shows an upward-narrowing kink band with an active anticlinal axial surface, consistent with fault-bend folding above an active thrust ramp. The Coyote Hills segment shows an active synclinal axial surface that coincides with the base of a 9-m-high scarp, consistent with tip-line folding or the presence of a backthrust. The seismic profiles pinpoint targets for future geologic work to constrain slip rates and ages of past events on this important fault system.

Guiding automated left ventricular chamber segmentation in cardiac imaging using the concept of conserved myocardial volume.

PubMed

Garson, Christopher D; Li, Bing; Acton, Scott T; Hossack, John A

2008-06-01

The active surface technique using gradient vector flow allows semi-automated segmentation of ventricular borders. The accuracy of the algorithm depends on the optimal selection of several key parameters. We investigated the use of conservation of myocardial volume for quantitative assessment of each of these parameters using synthetic and in vivo data. We predicted that for a given set of model parameters, strong conservation of volume would correlate with accurate segmentation. The metric was most useful when applied to the gradient vector field weighting and temporal step-size parameters, but less effective in guiding an optimal choice of the active surface tension and rigidity parameters.

Partially segmented deformable mirror

DOEpatents

Bliss, E.S.; Smith, J.R.; Salmon, J.T.; Monjes, J.A.

1991-05-21

A partially segmented deformable mirror is formed with a mirror plate having a smooth and continuous front surface and a plurality of actuators to its back surface. The back surface is divided into triangular areas which are mutually separated by grooves. The grooves are deep enough to make the plate deformable and the actuators for displacing the mirror plate in the direction normal to its surface are inserted in the grooves at the vertices of the triangular areas. Each actuator includes a transducer supported by a receptacle with outer shells having outer surfaces. The vertices have inner walls which are approximately perpendicular to the mirror surface and make planar contacts with the outer surfaces of the outer shells. The adhesive which is used on these contact surfaces tends to contract when it dries but the outer shells can bend and serve to minimize the tendency of the mirror to warp. 5 figures.

Partially segmented deformable mirror

DOEpatents

Bliss, Erlan S.; Smith, James R.; Salmon, J. Thaddeus; Monjes, Julio A.

1991-01-01

A partially segmented deformable mirror is formed with a mirror plate having a smooth and continuous front surface and a plurality of actuators to its back surface. The back surface is divided into triangular areas which are mutually separated by grooves. The grooves are deep enough to make the plate deformable and the actuators for displacing the mirror plate in the direction normal to its surface are inserted in the grooves at the vertices of the triangular areas. Each actuator includes a transducer supported by a receptacle with outer shells having outer surfaces. The vertices have inner walls which are approximately perpendicular to the mirror surface and make planar contacts with the outer surfaces of the outer shells. The adhesive which is used on these contact surfaces tends to contract when it dries but the outer shells can bend and serve to minimize the tendency of the mirror to warp.

Surface and Subsurface Fault Displacements from the September 2010 Darfield (Canterbury) Earthquake

NASA Astrophysics Data System (ADS)

Meyers, B.; Furlong, K. P.; Hayes, G. P.; Herman, M. W.; Quigley, M.

2012-12-01

On September 3, 2010 a Magnitude 7.1 earthquake struck near Darfield, New Zealand. This was to be the first earthquake in an ongoing, damaging sequence near the city of Christchurch. The earthquake produced a surface rupture with measurable offsets of up to 5.3m along a 30km surface fault system. The spatial pattern of slip during this rupture has been determined by various groups using a range of approaches and several independent data sets. Surface fault rupture was measured in the field and fault slip at depth has been inferred from a seismologic finite fault model (FFM) and various geodetic observations including GPS and InSAR. Here we compare the observed segmented surface displacements with fault slip inferred from the other data. Measurements of the surface rupture show segmented faulting consistent with subsurface slip in the FFM. In the FFM, the main slip patch near the hypocenter can be directly correlated to the region of maximum surface displacement. The FFM and some evidence in the InSAR data also indicate that the Greendale fault system, the structure responsible for the bulk of the rupture, continues at depth closer towards Christchurch than is seen in surface rupture patterns. There is an additional 20km long patch with up to 3m of modeled slip seen in the eastern end of the inverted fault, offset to the south from the Greendale fault trace. This additional fault segment is consistent with a zone of aftershock activity of the main Darfield event, and with local patterns of strong motion. It thus appears that slip recorded at the surface does not describe the entire fault system. This eastward extension of the September rupture means that there is only a short segment of unruptured crust remaining along the entire fault system involved in the Canterbury earthquake sequence.

Three-dimensional rendering of segmented object using matlab - biomed 2010.

PubMed

Anderson, Jeffrey R; Barrett, Steven F

2010-01-01

The three-dimensional rendering of microscopic objects is a difficult and challenging task that often requires specialized image processing techniques. Previous work has been described of a semi-automatic segmentation process of fluorescently stained neurons collected as a sequence of slice images with a confocal laser scanning microscope. Once properly segmented, each individual object can be rendered and studied as a three-dimensional virtual object. This paper describes the work associated with the design and development of Matlab files to create three-dimensional images from the segmented object data previously mentioned. Part of the motivation for this work is to integrate both the segmentation and rendering processes into one software application, providing a seamless transition from the segmentation tasks to the rendering and visualization tasks. Previously these tasks were accomplished on two different computer systems, windows and Linux. This transition basically limits the usefulness of the segmentation and rendering applications to those who have both computer systems readily available. The focus of this work is to create custom Matlab image processing algorithms for object rendering and visualization, and merge these capabilities to the Matlab files that were developed especially for the image segmentation task. The completed Matlab application will contain both the segmentation and rendering processes in a single graphical user interface, or GUI. This process for rendering three-dimensional images in Matlab requires that a sequence of two-dimensional binary images, representing a cross-sectional slice of the object, be reassembled in a 3D space, and covered with a surface. Additional segmented objects can be rendered in the same 3D space. The surface properties of each object can be varied by the user to aid in the study and analysis of the objects. This inter-active process becomes a powerful visual tool to study and understand microscopic objects.

Lateralization of music processing with noises in the auditory cortex: an fNIRS study.

PubMed

Santosa, Hendrik; Hong, Melissa Jiyoun; Hong, Keum-Shik

2014-01-01

The present study is to determine the effects of background noise on the hemispheric lateralization in music processing by exposing 14 subjects to four different auditory environments: music segments only, noise segments only, music + noise segments, and the entire music interfered by noise segments. The hemodynamic responses in both hemispheres caused by the perception of music in 10 different conditions were measured using functional near-infrared spectroscopy. As a feature to distinguish stimulus-evoked hemodynamics, the difference between the mean and the minimum value of the hemodynamic response for a given stimulus was used. The right-hemispheric lateralization in music processing was about 75% (instead of continuous music, only music segments were heard). If the stimuli were only noises, the lateralization was about 65%. But, if the music was mixed with noises, the right-hemispheric lateralization has increased. Particularly, if the noise was a little bit lower than the music (i.e., music level 10~15%, noise level 10%), the entire subjects showed the right-hemispheric lateralization: This is due to the subjects' effort to hear the music in the presence of noises. However, too much noise has reduced the subjects' discerning efforts.

Lateralization of music processing with noises in the auditory cortex: an fNIRS study

PubMed Central

Santosa, Hendrik; Hong, Melissa Jiyoun; Hong, Keum-Shik

2014-01-01

The present study is to determine the effects of background noise on the hemispheric lateralization in music processing by exposing 14 subjects to four different auditory environments: music segments only, noise segments only, music + noise segments, and the entire music interfered by noise segments. The hemodynamic responses in both hemispheres caused by the perception of music in 10 different conditions were measured using functional near-infrared spectroscopy. As a feature to distinguish stimulus-evoked hemodynamics, the difference between the mean and the minimum value of the hemodynamic response for a given stimulus was used. The right-hemispheric lateralization in music processing was about 75% (instead of continuous music, only music segments were heard). If the stimuli were only noises, the lateralization was about 65%. But, if the music was mixed with noises, the right-hemispheric lateralization has increased. Particularly, if the noise was a little bit lower than the music (i.e., music level 10~15%, noise level 10%), the entire subjects showed the right-hemispheric lateralization: This is due to the subjects' effort to hear the music in the presence of noises. However, too much noise has reduced the subjects' discerning efforts. PMID:25538583

Fast algorithm for probabilistic bone edge detection (FAPBED)

NASA Astrophysics Data System (ADS)

Scepanovic, Danilo; Kirshtein, Joshua; Jain, Ameet K.; Taylor, Russell H.

2005-04-01

The registration of preoperative CT to intra-operative reality systems is a crucial step in Computer Assisted Orthopedic Surgery (CAOS). The intra-operative sensors include 3D digitizers, fiducials, X-rays and Ultrasound (US). FAPBED is designed to process CT volumes for registration to tracked US data. Tracked US is advantageous because it is real time, noninvasive, and non-ionizing, but it is also known to have inherent inaccuracies which create the need to develop a framework that is robust to various uncertainties, and can be useful in US-CT registration. Furthermore, conventional registration methods depend on accurate and absolute segmentation. Our proposed probabilistic framework addresses the segmentation-registration duality, wherein exact segmentation is not a prerequisite to achieve accurate registration. In this paper, we develop a method for fast and automatic probabilistic bone surface (edge) detection in CT images. Various features that influence the likelihood of the surface at each spatial coordinate are combined using a simple probabilistic framework, which strikes a fair balance between a high-level understanding of features in an image and the low-level number crunching of standard image processing techniques. The algorithm evaluates different features for detecting the probability of a bone surface at each voxel, and compounds the results of these methods to yield a final, low-noise, probability map of bone surfaces in the volume. Such a probability map can then be used in conjunction with a similar map from tracked intra-operative US to achieve accurate registration. Eight sample pelvic CT scans were used to extract feature parameters and validate the final probability maps. An un-optimized fully automatic Matlab code runs in five minutes per CT volume on average, and was validated by comparison against hand-segmented gold standards. The mean probability assigned to nonzero surface points was 0.8, while nonzero non-surface points had a mean value of 0.38 indicating clear identification of surface points on average. The segmentation was also sufficiently crisp, with a full width at half maximum (FWHM) value of 1.51 voxels.

Digitized locksmith forensics: automated detection and segmentation of toolmarks on highly structured surfaces

NASA Astrophysics Data System (ADS)

Clausing, Eric; Vielhauer, Claus

2014-02-01

Locksmith forensics is an important area in crime scene forensics. Due to new optical, contactless, nanometer range sensing technology, such traces can be captured, digitized and analyzed more easily allowing a complete digital forensic investigation. In this paper we present a significantly improved approach for the detection and segmentation of toolmarks on surfaces of locking cylinder components (using the example of the locking cylinder component 'key pin') acquired by a 3D Confocal Laser Scanning Microscope. This improved approach is based on our prior work1 using a block-based classification approach with textural features. In this prior work1 we achieve a solid detection rate of 75-85% for the detection of toolmarks originating from illegal opening methods. Here, in this paper we improve, expand and fuse this prior approach with additional features from acquired surface topography data, color data and an image processing approach using adapted Gabor filters. In particular we are able of raising the detection and segmentation rates above 90% with our test set of 20 key pins with approximately 700 single toolmark traces of four different opening methods. We can provide a precise pixel- based segmentation as opposed to the rather imprecise segmentation of our prior block-based approach and as the use of the two additional data types (color and especially topography) require a specific pre-processing, we furthermore propose an adequate approach for this purpose.

Automatic 3D liver location and segmentation via convolutional neural network and graph cut.

PubMed

Lu, Fang; Wu, Fa; Hu, Peijun; Peng, Zhiyi; Kong, Dexing

2017-02-01

Segmentation of the liver from abdominal computed tomography (CT) images is an essential step in some computer-assisted clinical interventions, such as surgery planning for living donor liver transplant, radiotherapy and volume measurement. In this work, we develop a deep learning algorithm with graph cut refinement to automatically segment the liver in CT scans. The proposed method consists of two main steps: (i) simultaneously liver detection and probabilistic segmentation using 3D convolutional neural network; (ii) accuracy refinement of the initial segmentation with graph cut and the previously learned probability map. The proposed approach was validated on forty CT volumes taken from two public databases MICCAI-Sliver07 and 3Dircadb1. For the MICCAI-Sliver07 test dataset, the calculated mean ratios of volumetric overlap error (VOE), relative volume difference (RVD), average symmetric surface distance (ASD), root-mean-square symmetric surface distance (RMSD) and maximum symmetric surface distance (MSD) are 5.9, 2.7 %, 0.91, 1.88 and 18.94 mm, respectively. For the 3Dircadb1 dataset, the calculated mean ratios of VOE, RVD, ASD, RMSD and MSD are 9.36, 0.97 %, 1.89, 4.15 and 33.14 mm, respectively. The proposed method is fully automatic without any user interaction. Quantitative results reveal that the proposed approach is efficient and accurate for hepatic volume estimation in a clinical setup. The high correlation between the automatic and manual references shows that the proposed method can be good enough to replace the time-consuming and nonreproducible manual segmentation method.

Strain gauge ambiguity sensor for segmented mirror active optical system

NASA Technical Reports Server (NTRS)

Wyman, C. L.; Howe, T. L. (Inventor)

1974-01-01

A system is described to measure alignment between interfacing edges of mirror segments positioned to form a segmented mirror surface. It serves as a gauge having a bending beam with four piezoresistive elements coupled across the interfaces of the edges of adjacent mirror segments. The bending beam has a first position corresponding to alignment of the edges of adjacent mirror segments, and it is bendable from the first position in a direction and to a degree dependent upon the relative misalignment between the edges of adjacent mirror segments to correspondingly vary the resistance of the strain guage. A source of power and an amplifier are connected in circuit with the strain gauge whereby the output of the amplifier varies according to the misalignment of the edges of adjacent mirror segments.

Localized Segment Based Processing for Automatic Building Extraction from LiDAR Data

NASA Astrophysics Data System (ADS)

Parida, G.; Rajan, K. S.

2017-05-01

The current methods of object segmentation and extraction and classification of aerial LiDAR data is manual and tedious task. This work proposes a technique for object segmentation out of LiDAR data. A bottom-up geometric rule based approach was used initially to devise a way to segment buildings out of the LiDAR datasets. For curved wall surfaces, comparison of localized surface normals was done to segment buildings. The algorithm has been applied to both synthetic datasets as well as real world dataset of Vaihingen, Germany. Preliminary results show successful segmentation of the buildings objects from a given scene in case of synthetic datasets and promissory results in case of real world data. The advantages of the proposed work is non-dependence on any other form of data required except LiDAR. It is an unsupervised method of building segmentation, thus requires no model training as seen in supervised techniques. It focuses on extracting the walls of the buildings to construct the footprint, rather than focussing on roof. The focus on extracting the wall to reconstruct the buildings from a LiDAR scene is crux of the method proposed. The current segmentation approach can be used to get 2D footprints of the buildings, with further scope to generate 3D models. Thus, the proposed method can be used as a tool to get footprints of buildings in urban landscapes, helping in urban planning and the smart cities endeavour.

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes

PubMed Central

Tonkin-Hill, Gerry Q.; Trianty, Leily; Noviyanti, Rintis; Nguyen, Hanh H. T.; Sebayang, Boni F.; Lampah, Daniel A.; Marfurt, Jutta; Cobbold, Simon A.; Rambhatla, Janavi S.; McConville, Malcolm J.; Rogerson, Stephen J.; Brown, Graham V.; Day, Karen P.; Price, Ric N.; Anstey, Nicholas M.

2018-01-01

Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to—or is selected by—this environment remains unclear. From previous studies, the parasites that cause severe malaria appear to increase expression of a restricted but poorly defined subset of the PfEMP1 variant, surface antigens. PfEMP1s are major targets of protective immunity. Here, we used RNA sequencing (RNAseq) to analyse gene expression in 44 parasite isolates that caused severe and uncomplicated malaria in Papuan patients. The transcriptomes of 19 parasite isolates associated with severe malaria indicated that these parasites had decreased glycolysis without activation of compensatory pathways; altered chromatin structure and probably transcriptional regulation through decreased histone methylation; reduced surface expression of PfEMP1; and down-regulated expression of multiple chaperone proteins. Our RNAseq also identified novel associations between disease severity and PfEMP1 transcripts, domains, and smaller sequence segments and also confirmed all previously reported associations between expressed PfEMP1 sequences and severe disease. These findings will inform efforts to identify vaccine targets for severe malaria and also indicate how parasites adapt to—or are selected by—the host environment in severe malaria. PMID:29529020

Morphotectonic Index Analysis as an Indicator of Neotectonic Segmentation of the Nicoya Peninsula, Costa Rica

NASA Astrophysics Data System (ADS)

Morrish, S.; Marshall, J. S.

2013-12-01

The Nicoya Peninsula lies within the Costa Rican forearc where the Cocos plate subducts under the Caribbean plate at ~8.5 cm/yr. Rapid plate convergence produces frequent large earthquakes (~50yr recurrence interval) and pronounced crustal deformation (0.1-2.0m/ky uplift). Seven uplifted segments have been identified in previous studies using broad geomorphic surfaces (Hare & Gardner 1984) and late Quaternary marine terraces (Marshall et al. 2010). These surfaces suggest long term net uplift and segmentation of the peninsula in response to contrasting domains of subducting seafloor (EPR, CNS-1, CNS-2). In this study, newer 10m contour digital topographic data (CENIGA- Terra Project) will be used to characterize and delineate this segmentation using morphotectonic analysis of drainage basins and correlation of fluvial terrace/ geomorphic surface elevations. The peninsula has six primary watersheds which drain into the Pacific Ocean; the Río Andamojo, Río Tabaco, Río Nosara, Río Ora, Río Bongo, and Río Ario which range in area from 200 km2 to 350 km2. The trunk rivers follow major lineaments that define morphotectonic segment boundaries and in turn their drainage basins are bisected by them. Morphometric analysis of the lower (1st and 2nd) order drainage basins will provide insight into segmented tectonic uplift and deformation by comparing values of drainage basin asymmetry, stream length gradient, and hypsometry with respect to margin segmentation and subducting seafloor domain. A general geomorphic analysis will be conducted alongside the morphometric analysis to map previously recognized (Morrish et al. 2010) but poorly characterized late Quaternary fluvial terraces. Stream capture and drainage divide migration are common processes throughout the peninsula in response to the ongoing deformation. Identification and characterization of basin piracy throughout the peninsula will provide insight into the history of landscape evolution in response to differential uplift. Conducting this morphotectonic analysis of the Nicoya Peninsula will provide further constraints on rates of segment uplift, location of segment boundaries, and advance the understanding of the long term deformation of the region in relation to subduction.

Shape-intensity prior level set combining probabilistic atlas and probability map constrains for automatic liver segmentation from abdominal CT images.

PubMed

Wang, Jinke; Cheng, Yuanzhi; Guo, Changyong; Wang, Yadong; Tamura, Shinichi

2016-05-01

Propose a fully automatic 3D segmentation framework to segment liver on challenging cases that contain the low contrast of adjacent organs and the presence of pathologies from abdominal CT images. First, all of the atlases are weighted in the selected training datasets by calculating the similarities between the atlases and the test image to dynamically generate a subject-specific probabilistic atlas for the test image. The most likely liver region of the test image is further determined based on the generated atlas. A rough segmentation is obtained by a maximum a posteriori classification of probability map, and the final liver segmentation is produced by a shape-intensity prior level set in the most likely liver region. Our method is evaluated and demonstrated on 25 test CT datasets from our partner site, and its results are compared with two state-of-the-art liver segmentation methods. Moreover, our performance results on 10 MICCAI test datasets are submitted to the organizers for comparison with the other automatic algorithms. Using the 25 test CT datasets, average symmetric surface distance is [Formula: see text] mm (range 0.62-2.12 mm), root mean square symmetric surface distance error is [Formula: see text] mm (range 0.97-3.01 mm), and maximum symmetric surface distance error is [Formula: see text] mm (range 12.73-26.67 mm) by our method. Our method on 10 MICCAI test data sets ranks 10th in all the 47 automatic algorithms on the site as of July 2015. Quantitative results, as well as qualitative comparisons of segmentations, indicate that our method is a promising tool to improve the efficiency of both techniques. The applicability of the proposed method to some challenging clinical problems and the segmentation of the liver are demonstrated with good results on both quantitative and qualitative experimentations. This study suggests that the proposed framework can be good enough to replace the time-consuming and tedious slice-by-slice manual segmentation approach.

Segmental dynamics of polymers in nanoscopic confinements, as probed by simulations of polymer/layered-silicate nanocomposites.

PubMed

Kuppa, V; Foley, T M D; Manias, E

2003-09-01

In this paper we review molecular modeling investigations of polymer/layered-silicate intercalates, as model systems to explore polymers in nanoscopically confined spaces. The atomic-scale picture, as revealed by computer simulations, is presented in the context of salient results from a wide range of experimental techniques. This approach provides insights into how polymeric segmental dynamics are affected by severe geometric constraints. Focusing on intercalated systems, i.e. polystyrene (PS) in 2 nm wide slit-pores and polyethylene-oxide (PEO) in 1 nm wide slit-pores, a very rich picture for the segmental dynamics is unveiled, despite the topological constraints imposed by the confining solid surfaces. On a local scale, intercalated polymers exhibit a very wide distribution of segmental relaxation times (ranging from ultra-fast to ultra-slow, over a wide range of temperatures). In both cases (PS and PEO), the segmental relaxations originate from the confinement-induced local density variations. Additionally, where there exist special interactions between the polymer and the confining surfaces ( e.g., PEO) more molecular mechanisms are identified.

Speech segmentation in aphasia

PubMed Central

Peñaloza, Claudia; Benetello, Annalisa; Tuomiranta, Leena; Heikius, Ida-Maria; Järvinen, Sonja; Majos, Maria Carmen; Cardona, Pedro; Juncadella, Montserrat; Laine, Matti; Martin, Nadine; Rodríguez-Fornells, Antoni

2017-01-01

Background Speech segmentation is one of the initial and mandatory phases of language learning. Although some people with aphasia have shown a preserved ability to learn novel words, their speech segmentation abilities have not been explored. Aims We examined the ability of individuals with chronic aphasia to segment words from running speech via statistical learning. We also explored the relationships between speech segmentation and aphasia severity, and short-term memory capacity. We further examined the role of lesion location in speech segmentation and short-term memory performance. Methods & Procedures The experimental task was first validated with a group of young adults (n = 120). Participants with chronic aphasia (n = 14) were exposed to an artificial language and were evaluated in their ability to segment words using a speech segmentation test. Their performance was contrasted against chance level and compared to that of a group of elderly matched controls (n = 14) using group and case-by-case analyses. Outcomes & Results As a group, participants with aphasia were significantly above chance level in their ability to segment words from the novel language and did not significantly differ from the group of elderly controls. Speech segmentation ability in the aphasic participants was not associated with aphasia severity although it significantly correlated with word pointing span, a measure of verbal short-term memory. Case-by-case analyses identified four individuals with aphasia who performed above chance level on the speech segmentation task, all with predominantly posterior lesions and mild fluent aphasia. Their short-term memory capacity was also better preserved than in the rest of the group. Conclusions Our findings indicate that speech segmentation via statistical learning can remain functional in people with chronic aphasia and suggest that this initial language learning mechanism is associated with the functionality of the verbal short-term memory system and the integrity of the left inferior frontal region. PMID:28824218

Autonomous Segmentation of Outcrop Images Using Computer Vision and Machine Learning

NASA Astrophysics Data System (ADS)

Francis, R.; McIsaac, K.; Osinski, G. R.; Thompson, D. R.

2013-12-01

As planetary exploration missions become increasingly complex and capable, the motivation grows for improved autonomous science. New capabilities for onboard science data analysis may relieve radio-link data limits and provide greater throughput of scientific information. Adaptive data acquisition, storage and downlink may ultimately hold implications for mission design and operations. For surface missions, geology remains an essential focus, and the investigation of in place, exposed geological materials provides the greatest scientific insight and context for the formation and history of planetary materials and processes. The goal of this research program is to develop techniques for autonomous segmentation of images of rock outcrops. Recognition of the relationships between different geological units is the first step in mapping and interpreting a geological setting. Applications of automatic segmentation include instrument placement and targeting and data triage for downlink. Here, we report on the development of a new technique in which a photograph of a rock outcrop is processed by several elementary image processing techniques, generating a feature space which can be interrogated and classified. A distance metric learning technique (Multiclass Discriminant Analysis, or MDA) is tested as a means of finding the best numerical representation of the feature space. MDA produces a linear transformation that maximizes the separation between data points from different geological units. This ';training step' is completed on one or more images from a given locality. Then we apply the same transformation to improve the segmentation of new scenes containing similar materials to those used for training. The technique was tested using imagery from Mars analogue settings at the Cima volcanic flows in the Mojave Desert, California; impact breccias from the Sudbury impact structure in Ontario, Canada; and an outcrop showing embedded mineral veins in Gale Crater on Mars. These initial results show promising performance in segmenting images, including multi-class scenes with complex boundaries. In particular, the system was able to learn to distinguish between successive layers of volcanic deposits, including massive basalts overlaying lahar materials. It was also able to separate clasts from ground mass in outcrops of impact breccia, and to find veins of hydrated material within a clay-bearing host rock. The tests also reveal initial details about the types of visual information relevant to segmentation of these types of scenes, providing guidance for further development of the technique. Funding for this work was provided in part by the Canadian Astrobiology Training Program. A portion of this research was performed at the Jet Propulsion Laboratory, California Institute of Technology. Copyright 2013 The University of Western Ontario. All Rights Reserved.

A robustness test of the braided device foreshortening algorithm

NASA Astrophysics Data System (ADS)

Moyano, Raquel Kale; Fernandez, Hector; Macho, Juan M.; Blasco, Jordi; San Roman, Luis; Narata, Ana Paula; Larrabide, Ignacio

2017-11-01

Different computational methods have been recently proposed to simulate the virtual deployment of a braided stent inside a patient vasculature. Those methods are primarily based on the segmentation of the region of interest to obtain the local vessel morphology descriptors. The goal of this work is to evaluate the influence of the segmentation quality on the method named "Braided Device Foreshortening" (BDF). METHODS: We used the 3DRA images of 10 aneurysmatic patients (cases). The cases were segmented by applying a marching cubes algorithm with a broad range of thresholds in order to generate 10 surface models each. We selected a braided device to apply the BDF algorithm to each surface model. The range of the computed flow diverter lengths for each case was obtained to calculate the variability of the method against the threshold segmentation values. RESULTS: An evaluation study over 10 clinical cases indicates that the final length of the deployed flow diverter in each vessel model is stable, shielding maximum difference of 11.19% in vessel diameter and maximum of 9.14% in the simulated stent length for the threshold values. The average coefficient of variation was found to be 4.08 %. CONCLUSION: A study evaluating how the threshold segmentation affects the simulated length of the deployed FD, was presented. The segmentation algorithm used to segment intracranial aneurysm 3D angiography images presents small variation in the resulting stent simulation.

Radio Frequency Trap for Containment of Plasmas in Antimatter Propulsion Systems Using Rotating Wall Electric Fields

NASA Technical Reports Server (NTRS)

Sims, William Herbert, III (Inventor); Martin, James Joseph (Inventor); Lewis, Raymond A. (Inventor)

2003-01-01

A containment apparatus for containing a cloud of charged particles comprises a cylindrical vacuum chamber having a longitudinal axis. Within the vacuum chamber is a containment region. A magnetic field is aligned with the longitudinal axis of the vacuum chamber. The magnetic field is time invariant and uniform in strength over the containment region. An electric field is also aligned with the longitudinal axis of the vacuum chamber and the magnetic field. The electric field is time invariant, and forms a potential well over the containment region. One or more means are disposed around the cloud of particles for inducing a rotating electric field internal to the vacuum chamber. The rotating electric field imparts energy to the charged particles within the containment region and compress the cloud of particles. The means disposed around the outer surface of the vacuum chamber for inducing a rotating electric field are four or more segments forming a segmented ring, the segments conforming to the outer surface of the vacuum chamber. Each of the segments is energized by a separate alternating voltage. The sum of the voltages imposed on each segment establishes the rotating field. When four segments form a ring, the rotating field is obtained by a signal generator applying a sinusoidal signal phase delayed by 90,180 and 270 degrees in sequence to the four segments.

Late Holocene earthquake history of the Brigham City segment of the Wasatch fault zone at the Hansen Canyon, Kotter Canyon, and Pearsons Canyon trench sites, Box Elder County, Utah

USGS Publications Warehouse

DuRoss, Christopher B.; Personius, Stephen F.; Crone, Anthony J.; McDonald, Greg N.; Briggs, Richard W.

2012-01-01

Of the five central segments of the Wasatch fault zone (WFZ) having evidence of recurrent Holocene surface-faulting earthquakes, the Brigham City segment (BCS) has the longest elapsed time since its most recent surface-faulting event (~2.1 kyr) compared to its mean recurrence time between events (~1.3 kyr). Thus, the BCS has the highest time-dependent earthquake probability of the central WFZ. We excavated trenches at three sites––the Kotter Canyon and Hansen Canyon sites on the north-central BCS and Pearsons Canyon site on the southern BCS––to determine whether a surface-faulting earthquake younger than 2.1 ka occurred on the BCS. Paleoseismic data for Hansen Canyon and Kotter Canyon confirm that the youngest earthquake on the north-central BCS occurred before 2 ka, consistent with previous north-central BCS investigations at Bowden Canyon and Box Elder Canyon. At Hansen Canyon, the most recent earthquake is constrained to 2.1–4.2 ka and had 0.6–2.5 m of vertical displacement. At Kotter Canyon, we found evidence for two events at 2.5 ± 0.3 ka and 3.5 ± 0.3 ka, with an average displacement per event of 1.9–2.3 m. Paleoseismic data from Pearsons Canyon, on the previously unstudied southern BCS, indicate that a post-2 ka earthquake ruptured this part of the segment. The Pearsons Canyon earthquake occurred at 1.2 ± 0.04 ka and had 0.1–0.8 m of vertical displacement, consistent with our observation of continuous, youthful scarps on the southern 9 km of the BCS having 1–2 m of late Holocene(?) surface offset. The 1.2-ka earthquake on the southern BCS likely represents rupture across the Weber–Brigham City segment boundary from the penultimate Weber-segment earthquake at about 1.1 ka. The Pearsons Canyon data result in a revised length of the BCS that has not ruptured since 2 ka (with time-dependent probability implications), and provide compelling evidence of at least one segment-boundary failure and multi-segment rupture on the central WFZ. Our paleoseismic investigations of the BCS clarify the timing, displacement, and extent of late Holocene earthquakes on the segment, and importantly, confirm the long elapsed time since the most recent earthquake on most of the BCS.

Lymph node segmentation on CT images by a shape model guided deformable surface methodh

NASA Astrophysics Data System (ADS)

Maleike, Daniel; Fabel, Michael; Tetzlaff, Ralf; von Tengg-Kobligk, Hendrik; Heimann, Tobias; Meinzer, Hans-Peter; Wolf, Ivo

2008-03-01

With many tumor entities, quantitative assessment of lymph node growth over time is important to make therapy choices or to evaluate new therapies. The clinical standard is to document diameters on transversal slices, which is not the best measure for a volume. We present a new algorithm to segment (metastatic) lymph nodes and evaluate the algorithm with 29 lymph nodes in clinical CT images. The algorithm is based on a deformable surface search, which uses statistical shape models to restrict free deformation. To model lymph nodes, we construct an ellipsoid shape model, which strives for a surface with strong gradients and user-defined gray values. The algorithm is integrated into an application, which also allows interactive correction of the segmentation results. The evaluation shows that the algorithm gives good results in the majority of cases and is comparable to time-consuming manual segmentation. The median volume error was 10.1% of the reference volume before and 6.1% after manual correction. Integrated into an application, it is possible to perform lymph node volumetry for a whole patient within the 10 to 15 minutes time limit imposed by clinical routine.

Testing and Characterization of CMC Combustor Liners

NASA Technical Reports Server (NTRS)

Robinson, R. Craig; Verrilli, Michael J.

2003-01-01

Multiple combustor liner applications, both segmented and fully annular designs, have been configured for exposure in NASA's High Pressure Burner Rig (HPBR). The segmented liners were attached to the rig structure with SiC/SiC fasteners and exposed to simulated gas turbine conditions for nearly 200 hours. Test conditions included pressures of 6 atm., gas velocity of 42 m/s, and gas temperatures near 1450 C. The temperatures of both the cooled and combustion flow sides of the liners were measured using optical and contact measurement techniques. Minor weight loss was observed, but the liners remained structural sound, although damage was noted in some fasteners.

Chest wall segmentation in automated 3D breast ultrasound scans.

PubMed

Tan, Tao; Platel, Bram; Mann, Ritse M; Huisman, Henkjan; Karssemeijer, Nico

2013-12-01

In this paper, we present an automatic method to segment the chest wall in automated 3D breast ultrasound images. Determining the location of the chest wall in automated 3D breast ultrasound images is necessary in computer-aided detection systems to remove automatically detected cancer candidates beyond the chest wall and it can be of great help for inter- and intra-modal image registration. We show that the visible part of the chest wall in an automated 3D breast ultrasound image can be accurately modeled by a cylinder. We fit the surface of our cylinder model to a set of automatically detected rib-surface points. The detection of the rib-surface points is done by a classifier using features representing local image intensity patterns and presence of rib shadows. Due to attenuation of the ultrasound signal, a clear shadow is visible behind the ribs. Evaluation of our segmentation method is done by computing the distance of manually annotated rib points to the surface of the automatically detected chest wall. We examined the performance on images obtained with the two most common 3D breast ultrasound devices in the market. In a dataset of 142 images, the average mean distance of the annotated points to the segmented chest wall was 5.59 ± 3.08 mm. Copyright © 2012 Elsevier B.V. All rights reserved.

3D reconstruction of highly fragmented bone fractures

NASA Astrophysics Data System (ADS)

Willis, Andrew; Anderson, Donald; Thomas, Thad; Brown, Thomas; Marsh, J. Lawrence

2007-03-01

A system for the semi-automatic reconstruction of highly fragmented bone fractures, developed to aid in treatment planning, is presented. The system aligns bone fragment surfaces derived from segmentation of volumetric CT scan data. Each fragment surface is partitioned into intact- and fracture-surfaces, corresponding more or less to cortical and cancellous bone, respectively. A user then interactively selects fracture-surface patches in pairs that coarsely correspond. A final optimization step is performed automatically to solve the N-body rigid alignment problem. The work represents the first example of a 3D bone fracture reconstruction system and addresses two new problems unique to the reconstruction of fractured bones: (1) non-stationary noise inherent in surfaces generated from a difficult segmentation problem and (2) the possibility that a single fracture surface on a fragment may correspond to many other fragments.

Dynamic Cooperation of Hydrogen Binding and π Stacking in ssDNA Adsorption on Graphene Oxide.

PubMed

Xu, Zhen; Lei, Xiaoling; Tu, Yusong; Tan, Zhi-Jie; Song, Bo; Fang, Haiping

2017-09-21

Functional nanoscale structures consisting of a DNA molecule coupled to graphene or graphene oxide (GO) have great potential for applications in biosensors, biomedicine, nanotechnology, and materials science. Extensive studies using the most sophisticated experimental techniques and theoretical methods have still not clarified the dynamic process of single-stranded DNA (ssDNA) adsorbed on GO surfaces. Based on a molecular dynamics simulation, this work shows that an ssDNA segment could be stably adsorbed on a GO surface through hydrogen bonding and π-π stacking interactions, with preferential binding to the oxidized rather than to the unoxidized region of the GO surface. The adsorption process shows a dynamic cooperation adsorption behavior; the ssDNA segment first captures the oxidized groups of the GO surface by hydrogen bonding interaction, and then the configuration relaxes to maximize the π-π stacking interactions between the aromatic rings of the nucleobases and those of the GO surface. We attributed this behavior to the faster forming hydrogen bonding interaction compared to π-π stacking; the π-π stacking interaction needs more relaxation time to regulate the configuration of the ssDNA segment to fit the aromatic rings on the GO surface. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

In Vitro and In Vivo Measurement of Percutaneous Penetration of Low Molecular Weight Toxins of Military Interest

DTIC Science & Technology

1989-12-15

epidermal surfaces were exposed to ambient air (220C) during the entire length of the experiment. Penetration of [3H]PbTx-3 into skin layers and receptor...bathed by the receptor fluid and the epidermal surface was exposed to ambient conditions in an en- vironmental chamber. Temperature and relative...DMSO or water. The epidermal surfaces were exposed to ambient conditions in the environmental chamber. In order to determine if constituents leaching

He Said, She Said: Effects of Bilingualism on Cross-Talker Word Recognition in Infancy

ERIC Educational Resources Information Center

Singh, Leher

2018-01-01

The purpose of the current study was to examine effects of bilingual language input on infant word segmentation and on talker generalization. In the present study, monolingually and bilingually exposed infants were compared on their abilities to recognize familiarized words in speech and to maintain generalizable representations of familiarized…

Career Orientation Curriculum Guide: 7-8.

ERIC Educational Resources Information Center

Willoughby-Eastlake School District, Willoughby, OH.

The Ohio Career Development Model at the 7th and 8th grade level, the career orientation segment, states that students are to be exposed or oriented to the 15 USOE occupational clusters. Units are outlined relating each subject area to a specific cluster or clusters. Each unit includes a developmental objective, related behavioral objectives, and…

Pressure-actuated joint system

NASA Technical Reports Server (NTRS)

McGuire, John R. (Inventor)

2004-01-01

A pressure vessel is provided that includes first and second case segments mated with one another. First and second annular rubber layers are disposed inboard of the first and second case segments, respectively. The second annular rubber layer has a slot extending from the radial inner surface across a portion of its thickness to define a main body portion and a flexible portion. The flexible portion has an interfacing surface portion abutting against an interfacing surface portion of the first annular rubber layer to follow movement of the first annular rubber layer during operation of the pressure vessel. The slot receives pressurized gas and establishes a pressure-actuated joint between the interfacing surface portions. At least one of the interfacing surface portions has a plurality of enclosed and sealed recesses formed therein.

Platelet adhesive resistance of segmented polyurethane film surface-grafted with vinyl benzyl sulfo monomer of ammonium zwitterions.

PubMed

Zhang, Jun; Yuan, Jiang; Yuan, Youling; Zang, Xiaopeng; Shen, Jian; Lin, Sicong

2003-10-01

Platelet from human plasma adhered on the segmented poly(ether urethane) (SPEU) film grafted with N,N-dimethyl-N-(p-vinylbenyl)-N-(3-sulfopropyl) ammonium (DMVSA) was studied. SPEU films were hydroxylated by potassium peroxosulfate (KPS) and then grafted with DMVSA using ceric ammonium nitrate (CAN) as initiator. The mixing time of hydroxylated SPEU/CAN and the monomer concentration effect on graft polymerization yield were determined by ATR-FTIR. Surface analysis of the grafted films by ATR-FTIR and ESCA confirmed that DMVSA was successfully grafted onto the SPEU film surface. The grafted film possessed a relatively hydrophilic surface, as revealed by water contact angle measurement. The improved blood compatibility of the grafted films was preliminarily evaluated by a platelet-rich plasma adhesion study and scanning electron microscopy, using original SPEU and hydroxylated SPEU films as the controls. The results showed that platelet attachment was decreased greatly on the segmented polyurethane films grafted with DMVSA. This kind of new biomaterials grafted with sulfo ammonium zwitterionic monomers might have potential for biomedical applications.

Performances of biological aerated filter employing hollow fiber membrane segments of surface-improved poly (sulfone) as biofilm carriers.

PubMed

Shen, Ying-Jie; Wu, Guang-Xia; Fan, Yao-Bo; Zhong, Hui; Wu, Lin-Lin; Zhang, Shao-Lai; Zhao, Xian-Hong; Zhang, Wei-Jun

2007-01-01

Using the surface of poly (sulfone) hollow fiber membrane segments as grafted layer, the hydrophilic acrylamide chain was grafted on by UV-photoinduced grafting polymerization. The gained improvement of surface wettability for the modified membrane was tested by measuring the contact-angle as well as FTIR spectra. Then correlation between the hydrophilic ability of support material and the biofilm adherence ability was demonstrated by comparing the pollutant removal rates from urban wastewater via two identical lab-scale up-flow biological aerated filters, one employed the surface wettability modified poly (sulfone) hollow fiber membrane segment as biofilm carrier and the other employed unmodified membrane segment as biofilm carrier. The experimental results showed that under the conditions of influent flux 5 L/h, hydraulic retention time 9 h and gas to liquid ratio (G/L) 10:1, the removal rates of chemical oxygen demand (COD) and ammonium nitrogen (NH4(+)-N) for the modified packing filter and the unmodified packing filter was averaged at 83.64% and 96.25%, respectively, with the former filter being 5%-20% more than the latter. The effluent concentration of COD, NH4(+)-N and turbidity for the modified packing filter was 25.25 mg/L, 2 mg/L and 8 NTU, respectively. Moreover, the ammonium nitrogen removal performance of the filter packing the modified PSF was compared with the other bioreactor packing of an efficient floating medium. The biomass test indicated that the modified membrane matrixes provided better specific adhesion (3310-5653 mg TSS/L support), which gave a mean of 1000 mg TSS/L more than the unmodified membrane did. In addition, the phenomenon of simultaneous denitrification on the inner surface of the support and nitrification on the outer surface was found in this work.

RSRM nozzle fixed housing cooldown test

NASA Technical Reports Server (NTRS)

Bolieau, D. J.

1989-01-01

Flight 5 aft segments with nozzles were exposed to -17 F temperatures while awaiting shipment to KSC in February, 1989. No records were found which show that any previous nozzles were exposed to air temperatures as low as those seen by the Flight 5 nozzles. Thermal analysis shows that the temperature of the fixed housing, and forward and aft exit cone components dropped as low as -10 F. Structural analysis of the nozzles at these low temperatures show the forward and aft exit cone adhesive bonds to have a positive margin of safety, based on a 2.0 safety factor. These analyses show the normal and shear stresses in the fixed housing bond as low values. However, the hoop and meridinal stresses were predicted to be in the 4000 psi range; the failure stress allowable of EA913NA adhesive at -7 F. If the bonds did break in directions perpendicular to the surfaces, called bond crazing, no normal bond strength would be lost. Testing was conducted in two phases, showing that no degradation to the adhesive bonds occurred while the Flight 5 nozzles were subjected to subzero temperatures. The results of these tests are documented. Phase 1 testing cooled a full-scale RSRM insulated fixed housing to -13 F, with extensive bondline inspections. Phase 2 testing cooled the witness panel adhesive tensile buttions to -13 F, with failure strengths recorded before, during, and after the cooldown.

Intra-temporal facial nerve centerline segmentation for navigated temporal bone surgery

NASA Astrophysics Data System (ADS)

Voormolen, Eduard H. J.; van Stralen, Marijn; Woerdeman, Peter A.; Pluim, Josien P. W.; Noordmans, Herke J.; Regli, Luca; Berkelbach van der Sprenkel, Jan W.; Viergever, Max A.

2011-03-01

Approaches through the temporal bone require surgeons to drill away bone to expose a target skull base lesion while evading vital structures contained within it, such as the sigmoid sinus, jugular bulb, and facial nerve. We hypothesize that an augmented neuronavigation system that continuously calculates the distance to these structures and warns if the surgeon drills too close, will aid in making safe surgical approaches. Contemporary image guidance systems are lacking an automated method to segment the inhomogeneous and complexly curved facial nerve. Therefore, we developed a segmentation method to delineate the intra-temporal facial nerve centerline from clinically available temporal bone CT images semi-automatically. Our method requires the user to provide the start- and end-point of the facial nerve in a patient's CT scan, after which it iteratively matches an active appearance model based on the shape and texture of forty facial nerves. Its performance was evaluated on 20 patients by comparison to our gold standard: manually segmented facial nerve centerlines. Our segmentation method delineates facial nerve centerlines with a maximum error along its whole trajectory of 0.40+/-0.20 mm (mean+/-standard deviation). These results demonstrate that our model-based segmentation method can robustly segment facial nerve centerlines. Next, we can investigate whether integration of this automated facial nerve delineation with a distance calculating neuronavigation interface results in a system that can adequately warn surgeons during temporal bone drilling, and effectively diminishes risks of iatrogenic facial nerve palsy.

Bone surface enhancement in ultrasound images using a new Doppler-based acquisition/processing method.

PubMed

Yang, Xu; Tang, Songyuan; Tasciotti, Ennio; Righetti, Raffaella

2018-01-17

Ultrasound (US) imaging has long been considered as a potential aid in orthopedic surgeries. US technologies are safe, portable and do not use radiations. This would make them a desirable tool for real-time assessment of fractures and to monitor fracture healing. However, image quality of US imaging methods in bone applications is limited by speckle, attenuation, shadow, multiple reflections and other imaging artifacts. While bone surfaces typically appear in US images as somewhat 'brighter' than soft tissue, they are often not easily distinguishable from the surrounding tissue. Therefore, US imaging methods aimed at segmenting bone surfaces need enhancement in image contrast prior to segmentation to improve the quality of the detected bone surface. In this paper, we present a novel acquisition/processing technique for bone surface enhancement in US images. Inspired by elastography and Doppler imaging methods, this technique takes advantage of the difference between the mechanical and acoustic properties of bones and those of soft tissues to make the bone surface more easily distinguishable in US images. The objective of this technique is to facilitate US-based bone segmentation methods and improve the accuracy of their outcomes. The newly proposed technique is tested both in in vitro and in vivo experiments. The results of these preliminary experiments suggest that the use of the proposed technique has the potential to significantly enhance the detectability of bone surfaces in noisy ultrasound images.

Bone surface enhancement in ultrasound images using a new Doppler-based acquisition/processing method

NASA Astrophysics Data System (ADS)

Yang, Xu; Tang, Songyuan; Tasciotti, Ennio; Righetti, Raffaella

2018-01-01

Ultrasound (US) imaging has long been considered as a potential aid in orthopedic surgeries. US technologies are safe, portable and do not use radiations. This would make them a desirable tool for real-time assessment of fractures and to monitor fracture healing. However, image quality of US imaging methods in bone applications is limited by speckle, attenuation, shadow, multiple reflections and other imaging artifacts. While bone surfaces typically appear in US images as somewhat ‘brighter’ than soft tissue, they are often not easily distinguishable from the surrounding tissue. Therefore, US imaging methods aimed at segmenting bone surfaces need enhancement in image contrast prior to segmentation to improve the quality of the detected bone surface. In this paper, we present a novel acquisition/processing technique for bone surface enhancement in US images. Inspired by elastography and Doppler imaging methods, this technique takes advantage of the difference between the mechanical and acoustic properties of bones and those of soft tissues to make the bone surface more easily distinguishable in US images. The objective of this technique is to facilitate US-based bone segmentation methods and improve the accuracy of their outcomes. The newly proposed technique is tested both in in vitro and in vivo experiments. The results of these preliminary experiments suggest that the use of the proposed technique has the potential to significantly enhance the detectability of bone surfaces in noisy ultrasound images.

Regional growth and atlasing of the developing human brain

PubMed Central

Makropoulos, Antonios; Aljabar, Paul; Wright, Robert; Hüning, Britta; Merchant, Nazakat; Arichi, Tomoki; Tusor, Nora; Hajnal, Joseph V.; Edwards, A. David; Counsell, Serena J.; Rueckert, Daniel

2016-01-01

Detailed morphometric analysis of the neonatal brain is required to characterise brain development and define neuroimaging biomarkers related to impaired brain growth. Accurate automatic segmentation of neonatal brain MRI is a prerequisite to analyse large datasets. We have previously presented an accurate and robust automatic segmentation technique for parcellating the neonatal brain into multiple cortical and subcortical regions. In this study, we further extend our segmentation method to detect cortical sulci and provide a detailed delineation of the cortical ribbon. These detailed segmentations are used to build a 4-dimensional spatio-temporal structural atlas of the brain for 82 cortical and subcortical structures throughout this developmental period. We employ the algorithm to segment an extensive database of 420 MR images of the developing brain, from 27 to 45 weeks post-menstrual age at imaging. Regional volumetric and cortical surface measurements are derived and used to investigate brain growth and development during this critical period and to assess the impact of immaturity at birth. Whole brain volume, the absolute volume of all structures studied, cortical curvature and cortical surface area increased with increasing age at scan. Relative volumes of cortical grey matter, cerebellum and cerebrospinal fluid increased with age at scan, while relative volumes of white matter, ventricles, brainstem and basal ganglia and thalami decreased. Preterm infants at term had smaller whole brain volumes, reduced regional white matter and cortical and subcortical grey matter volumes, and reduced cortical surface area compared with term born controls, while ventricular volume was greater in the preterm group. Increasing prematurity at birth was associated with a reduction in total and regional white matter, cortical and subcortical grey matter volume, an increase in ventricular volume, and reduced cortical surface area. PMID:26499811

Regional growth and atlasing of the developing human brain.

PubMed

Makropoulos, Antonios; Aljabar, Paul; Wright, Robert; Hüning, Britta; Merchant, Nazakat; Arichi, Tomoki; Tusor, Nora; Hajnal, Joseph V; Edwards, A David; Counsell, Serena J; Rueckert, Daniel

2016-01-15

Detailed morphometric analysis of the neonatal brain is required to characterise brain development and define neuroimaging biomarkers related to impaired brain growth. Accurate automatic segmentation of neonatal brain MRI is a prerequisite to analyse large datasets. We have previously presented an accurate and robust automatic segmentation technique for parcellating the neonatal brain into multiple cortical and subcortical regions. In this study, we further extend our segmentation method to detect cortical sulci and provide a detailed delineation of the cortical ribbon. These detailed segmentations are used to build a 4-dimensional spatio-temporal structural atlas of the brain for 82 cortical and subcortical structures throughout this developmental period. We employ the algorithm to segment an extensive database of 420 MR images of the developing brain, from 27 to 45weeks post-menstrual age at imaging. Regional volumetric and cortical surface measurements are derived and used to investigate brain growth and development during this critical period and to assess the impact of immaturity at birth. Whole brain volume, the absolute volume of all structures studied, cortical curvature and cortical surface area increased with increasing age at scan. Relative volumes of cortical grey matter, cerebellum and cerebrospinal fluid increased with age at scan, while relative volumes of white matter, ventricles, brainstem and basal ganglia and thalami decreased. Preterm infants at term had smaller whole brain volumes, reduced regional white matter and cortical and subcortical grey matter volumes, and reduced cortical surface area compared with term born controls, while ventricular volume was greater in the preterm group. Increasing prematurity at birth was associated with a reduction in total and regional white matter, cortical and subcortical grey matter volume, an increase in ventricular volume, and reduced cortical surface area. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Automatic detection of left and right ventricles from CTA enables efficient alignment of anatomy with myocardial perfusion data.

PubMed

Piccinelli, Marina; Faber, Tracy L; Arepalli, Chesnal D; Appia, Vikram; Vinten-Johansen, Jakob; Schmarkey, Susan L; Folks, Russell D; Garcia, Ernest V; Yezzi, Anthony

2014-02-01

Accurate alignment between cardiac CT angiographic studies (CTA) and nuclear perfusion images is crucial for improved diagnosis of coronary artery disease. This study evaluated in an animal model the accuracy of a CTA fully automated biventricular segmentation algorithm, a necessary step for automatic and thus efficient PET/CT alignment. Twelve pigs with acute infarcts were imaged using Rb-82 PET and 64-slice CTA. Post-mortem myocardium mass measurements were obtained. Endocardial and epicardial myocardial boundaries were manually and automatically detected on the CTA and both segmentations used to perform PET/CT alignment. To assess the segmentation performance, image-based myocardial masses were compared to experimental data; the hand-traced profiles were used as a reference standard to assess the global and slice-by-slice robustness of the automated algorithm in extracting myocardium, LV, and RV. Mean distances between the automated and the manual 3D segmented surfaces were computed. Finally, differences in rotations and translations between the manual and automatic surfaces were estimated post-PET/CT alignment. The largest, smallest, and median distances between interactive and automatic surfaces averaged 1.2 ± 2.1, 0.2 ± 1.6, and 0.7 ± 1.9 mm. The average angular and translational differences in CT/PET alignments were 0.4°, -0.6°, and -2.3° about x, y, and z axes, and 1.8, -2.1, and 2.0 mm in x, y, and z directions. Our automatic myocardial boundary detection algorithm creates surfaces from CTA that are similar in accuracy and provide similar alignments with PET as those obtained from interactive tracing. Specific difficulties in a reliable segmentation of the apex and base regions will require further improvements in the automated technique.

Structure of yeast Argonaute with guide RNA

PubMed Central

Nakanishi, Kotaro; Weinberg, David E.; Bartel, David P.; Patel, Dinshaw J.

2012-01-01

The RNA-induced silencing complex, comprising Argonaute and guide RNA, mediates RNA interference. Here we report the 3.2 Å crystal structure of Kluyveromyces Argonaute (KpAGO) fortuitously complexed with guide RNA originating from small-RNA duplexes autonomously loaded and processed by recombinant KpAGO. Despite their diverse sequences, guide-RNA nucleotides 1–8 are positioned similarly, with sequence-independent contacts to bases, phosphates and 2′-hydroxyl groups pre-organizing the backbone of nucleotides 2–8 in a near–A-form conformation. Compared with prokaryotic Argonautes, KpAGO has numerous surface-exposed insertion segments, with a cluster of conserved insertions repositioning the N domain to enable full propagation of guide–target pairing. Compared with Argonautes in inactive conformations, KpAGO has a hydrogen-bond network that stabilizes an expanded and repositioned loop, which inserts an invariant glutamate into the catalytic pocket. Mutation analyses and analogies to Ribonuclease H indicate that insertion of this glutamate finger completes a universally conserved catalytic tetrad, thereby activating Argonaute for RNA cleavage. PMID:22722195

Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls

NASA Astrophysics Data System (ADS)

Hossain, Shaolie S.; Hossainy, Syed F. A.; Bazilevs, Yuri; Calo, Victor M.; Hughes, Thomas J. R.

2012-02-01

The majority of heart attacks occur when there is a sudden rupture of atherosclerotic plaque, exposing prothrombotic emboli to coronary blood flow, forming clots that can cause blockages of the arterial lumen. Diseased arteries can be treated with drugs delivered locally to vulnerable plaques. The objective of this work was to develop a computational tool-set to support the design and analysis of a catheter-based nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. A three-dimensional mathematical model of coupled mass transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis. Simulations were run on a patient-specific multilayered coronary artery wall segment with a vulnerable plaque and the effect of artery and plaque inhomogeneity was analyzed. The method captured trends observed in local drug delivery and demonstrated potential for optimizing drug design parameters, including delivery location, nanoparticle surface properties, and drug release rate.

The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation

NASA Astrophysics Data System (ADS)

Kühn, Sonja; Erdmann, Constanze; Kage, Frieda; Block, Jennifer; Schwenkmezger, Lisa; Steffen, Anika; Rottner, Klemens; Geyer, Matthias

2015-05-01

Formins are actin polymerization factors that elongate unbranched actin filaments at the barbed end. Rho family GTPases activate Diaphanous-related formins through the relief of an autoregulatory interaction. The crystal structures of the N-terminal domains of human FMNL1 and FMNL2 in complex with active Cdc42 show that Cdc42 mediates contacts with all five armadillo repeats of the formin with specific interactions formed by the Rho-GTPase insert helix. Mutation of three residues within Rac1 results in a gain-of-function mutation for FMNL2 binding and reconstitution of the Cdc42 phenotype in vivo. Dimerization of FMNL1 through a parallel coiled coil segment leads to formation of an umbrella-shaped structure that--together with Cdc42--spans more than 15 nm in diameter. The two interacting FMNL-Cdc42 heterodimers expose six membrane interaction motifs on a convex protein surface, the assembly of which may facilitate actin filament elongation at the leading edge of lamellipodia and filopodia.

Tomographic particle image velocimetry of desert locust wakes: instantaneous volumes combine to reveal hidden vortex elements and rapid wake deformation

PubMed Central

Bomphrey, Richard J.; Henningsson, Per; Michaelis, Dirk; Hollis, David

2012-01-01

Aerodynamic structures generated by animals in flight are unstable and complex. Recent progress in quantitative flow visualization has advanced our understanding of animal aerodynamics, but measurements have hitherto been limited to flow velocities at a plane through the wake. We applied an emergent, high-speed, volumetric fluid imaging technique (tomographic particle image velocimetry) to examine segments of the wake of desert locusts, capturing fully three-dimensional instantaneous flow fields. We used those flow fields to characterize the aerodynamic footprint in unprecedented detail and revealed previously unseen wake elements that would have gone undetected by two-dimensional or stereo-imaging technology. Vortex iso-surface topographies show the spatio-temporal signature of aerodynamic force generation manifest in the wake of locusts, and expose the extent to which animal wakes can deform, potentially leading to unreliable calculations of lift and thrust when using conventional diagnostic methods. We discuss implications for experimental design and analysis as volumetric flow imaging becomes more widespread. PMID:22977102

The MATROSHKA experiment: results and comparison from extravehicular activity (MTR-1) and intravehicular activity (MTR-2A/2B) exposure.

PubMed

Berger, Thomas; Bilski, Paweł; Hajek, Michael; Puchalska, Monika; Reitz, Günther

2013-12-01

Astronauts working and living in space are exposed to considerably higher doses and different qualities of ionizing radiation than people on Earth. The multilateral MATROSHKA (MTR) experiment, coordinated by the German Aerospace Center, represents the most comprehensive effort to date in radiation protection dosimetry in space using an anthropomorphic upper-torso phantom used for radiotherapy treatment planning. The anthropomorphic upper-torso phantom maps the radiation distribution as a simulated human body installed outside (MTR-1) and inside different compartments (MTR-2A: Pirs; MTR-2B: Zvezda) of the Russian Segment of the International Space Station. Thermoluminescence dosimeters arranged in a 2.54 cm orthogonal grid, at the site of vital organs and on the surface of the phantom allow for visualization of the absorbed dose distribution with superior spatial resolution. These results should help improve the estimation of radiation risks for long-term human space exploration and support benchmarking of radiation transport codes.

Eliciting affect via immersive virtual reality: a tool for adolescent risk reduction.

PubMed

Hadley, Wendy; Houck, Christopher D; Barker, David H; Garcia, Abbe Marrs; Spitalnick, Josh S; Curtis, Virginia; Roye, Scott; Brown, Larry K

2014-04-01

A virtual reality environment (VRE) was designed to expose participants to substance use and sexual risk-taking cues to examine the utility of VR in eliciting adolescent physiological arousal. 42 adolescents (55% male) with a mean age of 14.54 years (SD = 1.13) participated. Physiological arousal was examined through heart rate (HR), respiratory sinus arrhythmia (RSA), and self-reported somatic arousal. A within-subject design (neutral VRE, VR party, and neutral VRE) was utilized to examine changes in arousal. The VR party demonstrated an increase in physiological arousal relative to a neutral VRE. Examination of individual segments of the party (e.g., orientation, substance use, and sexual risk) demonstrated that HR was significantly elevated across all segments, whereas only the orientation and sexual risk segments demonstrated significant impact on RSA. This study provides preliminary evidence that VREs can be used to generate physiological arousal in response to substance use and sexual risk cues.

Model-Based Segmentation of Cortical Regions of Interest for Multi-subject Analysis of fMRI Data

NASA Astrophysics Data System (ADS)

Engel, Karin; Brechmann, Andr'e.; Toennies, Klaus

The high inter-subject variability of human neuroanatomy complicates the analysis of functional imaging data across subjects. We propose a method for the correct segmentation of cortical regions of interest based on the cortical surface. First results on the segmentation of Heschl's gyrus indicate the capability of our approach for correct comparison of functional activations in relation to individual cortical patterns.

Left-ventricle segmentation in real-time 3D echocardiography using a hybrid active shape model and optimal graph search approach

NASA Astrophysics Data System (ADS)

Zhang, Honghai; Abiose, Ademola K.; Campbell, Dwayne N.; Sonka, Milan; Martins, James B.; Wahle, Andreas

2010-03-01

Quantitative analysis of the left ventricular shape and motion patterns associated with left ventricular mechanical dyssynchrony (LVMD) is essential for diagnosis and treatment planning in congestive heart failure. Real-time 3D echocardiography (RT3DE) used for LVMD analysis is frequently limited by heavy speckle noise or partially incomplete data, thus a segmentation method utilizing learned global shape knowledge is beneficial. In this study, the endocardial surface of the left ventricle (LV) is segmented using a hybrid approach combining active shape model (ASM) with optimal graph search. The latter is used to achieve landmark refinement in the ASM framework. Optimal graph search translates the 3D segmentation into the detection of a minimum-cost closed set in a graph and can produce a globally optimal result. Various information-gradient, intensity distributions, and regional-property terms-are used to define the costs for the graph search. The developed method was tested on 44 RT3DE datasets acquired from 26 LVMD patients. The segmentation accuracy was assessed by surface positioning error and volume overlap measured for the whole LV as well as 16 standard LV regions. The segmentation produced very good results that were not achievable using ASM or graph search alone.

Edges in CNC polishing: from mirror-segments towards semiconductors, paper 1: edges on processing the global surface.

PubMed

Walker, David; Yu, Guoyu; Li, Hongyu; Messelink, Wilhelmus; Evans, Rob; Beaucamp, Anthony

2012-08-27

Segment-edges for extremely large telescopes are critical for observations requiring high contrast and SNR, e.g. detecting exo-planets. In parallel, industrial requirements for edge-control are emerging in several applications. This paper reports on a new approach, where edges are controlled throughout polishing of the entire surface of a part, which has been pre-machined to its final external dimensions. The method deploys compliant bonnets delivering influence functions of variable diameter, complemented by small pitch tools sized to accommodate aspheric mis-fit. We describe results on witness hexagons in preparation for full size prototype segments for the European Extremely Large Telescope, and comment on wider applications of the technology.

Determining eyeball surface area directly exposed to the effects of external factors.

PubMed

Juliszewski, Tadeusz; Kadłuczka, Filip; Kiełbasa, Paweł

2016-01-01

This article discusses determining the surface area of eyeballs of men and women exposed to the direct effects of external factors in the working environment. For one eye, the mean surface is 172-182 mm(2). The determined surface area can be used in formulas for calculating the exposure of eyeballs to harmful chemical substances in workplace air.

San Andreas fault geometry in the Parkfield, California, region

USGS Publications Warehouse

Simpson, R.W.; Barall, M.; Langbein, J.; Murray, J.R.; Rymer, M.J.

2006-01-01

In map view, aftershocks of the 2004 Parkfield earthquake lie along a line that forms a straighter connection between San Andreas fault segments north and south of the Parkfield reach than does the mapped trace of the fault itself. A straightedge laid on a geologic map of Central California reveals a ???50-km-long asymmetric northeastward warp in the Parkfield reach of the fault. The warp tapers gradually as it joins the straight, creeping segment of the San Andreas to the north-west, but bends abruptly across Cholame Valley at its southeast end to join the straight, locked segment that last ruptured in 1857. We speculate that the San Andreas fault surface near Parkfield has been deflected in its upper ???6 km by nonelastic behavior of upper crustal rock units. These units and the fault surface itself are warped during periods between large 1857-type earthquakes by the presence of the 1857-locked segment to the south, which buttresses intermittent coseismic and continuous aseismic slip on the Parkfield reach. Because of nonelastic behavior, the warping is not completely undone when an 1857-type event occurs, and the upper portion of the three-dimensional fault surface is slowly ratcheted into an increasingly prominent bulge. Ultimately, the fault surface probably becomes too deformed for strike-slip motion, and a new, more vertical connection to the Earth's surface takes over, perhaps along the Southwest Fracture Zone. When this happens a wedge of material currently west of the main trace will be stranded on the east side of the new main trace.

Diminutives facilitate word segmentation in natural speech: cross-linguistic evidence.

PubMed

Kempe, Vera; Brooks, Patricia J; Gillis, Steven; Samson, Graham

2007-06-01

Final-syllable invariance is characteristic of diminutives (e.g., doggie), which are a pervasive feature of the child-directed speech registers of many languages. Invariance in word endings has been shown to facilitate word segmentation (Kempe, Brooks, & Gillis, 2005) in an incidental-learning paradigm in which synthesized Dutch pseudonouns were used. To broaden the cross-linguistic evidence for this invariance effect and to increase its ecological validity, adult English speakers (n=276) were exposed to naturally spoken Dutch or Russian pseudonouns presented in sentence contexts. A forced choice test was given to assess target recognition, with foils comprising unfamiliar syllable combinations in Experiments 1 and 2 and syllable combinations straddling word boundaries in Experiment 3. A control group (n=210) received the recognition test with no prior exposure to targets. Recognition performance improved with increasing final-syllable rhyme invariance, with larger increases for the experimental group. This confirms that word ending invariance is a valid segmentation cue in artificial, as well as naturalistic, speech and that diminutives may aid segmentation in a number of languages.

Reactor vessel seal service fixture

DOEpatents

Ritz, W.C.

1975-12-01

An apparatus for the preparation of exposed sealing surfaces along the open rim of a nuclear reactor vessel comprised of a motorized mechanism for traveling along the rim and simultaneously brushing the exposed surfaces is described.

Photon-triggered nanowire transistors

NASA Astrophysics Data System (ADS)

Kim, Jungkil; Lee, Hoo-Cheol; Kim, Kyoung-Ho; Hwang, Min-Soo; Park, Jin-Sung; Lee, Jung Min; So, Jae-Pil; Choi, Jae-Hyuck; Kwon, Soon-Hong; Barrelet, Carl J.; Park, Hong-Gyu

2017-10-01

Photon-triggered electronic circuits have been a long-standing goal of photonics. Recent demonstrations include either all-optical transistors in which photons control other photons or phototransistors with the gate response tuned or enhanced by photons. However, only a few studies report on devices in which electronic currents are optically switched and amplified without an electrical gate. Here we show photon-triggered nanowire (NW) transistors, photon-triggered NW logic gates and a single NW photodetection system. NWs are synthesized with long crystalline silicon (CSi) segments connected by short porous silicon (PSi) segments. In a fabricated device, the electrical contacts on both ends of the NW are connected to a single PSi segment in the middle. Exposing the PSi segment to light triggers a current in the NW with a high on/off ratio of >8 × 106. A device that contains two PSi segments along the NW can be triggered using two independent optical input signals. Using localized pump lasers, we demonstrate photon-triggered logic gates including AND, OR and NAND gates. A photon-triggered NW transistor of diameter 25 nm with a single 100 nm PSi segment requires less than 300 pW of power. Furthermore, we take advantage of the high photosensitivity and fabricate a submicrometre-resolution photodetection system. Photon-triggered transistors offer a new venue towards multifunctional device applications such as programmable logic elements and ultrasensitive photodetectors.

Photon-triggered nanowire transistors.

PubMed

Kim, Jungkil; Lee, Hoo-Cheol; Kim, Kyoung-Ho; Hwang, Min-Soo; Park, Jin-Sung; Lee, Jung Min; So, Jae-Pil; Choi, Jae-Hyuck; Kwon, Soon-Hong; Barrelet, Carl J; Park, Hong-Gyu

2017-10-01

Photon-triggered electronic circuits have been a long-standing goal of photonics. Recent demonstrations include either all-optical transistors in which photons control other photons or phototransistors with the gate response tuned or enhanced by photons. However, only a few studies report on devices in which electronic currents are optically switched and amplified without an electrical gate. Here we show photon-triggered nanowire (NW) transistors, photon-triggered NW logic gates and a single NW photodetection system. NWs are synthesized with long crystalline silicon (CSi) segments connected by short porous silicon (PSi) segments. In a fabricated device, the electrical contacts on both ends of the NW are connected to a single PSi segment in the middle. Exposing the PSi segment to light triggers a current in the NW with a high on/off ratio of >8 × 10 6 . A device that contains two PSi segments along the NW can be triggered using two independent optical input signals. Using localized pump lasers, we demonstrate photon-triggered logic gates including AND, OR and NAND gates. A photon-triggered NW transistor of diameter 25 nm with a single 100 nm PSi segment requires less than 300 pW of power. Furthermore, we take advantage of the high photosensitivity and fabricate a submicrometre-resolution photodetection system. Photon-triggered transistors offer a new venue towards multifunctional device applications such as programmable logic elements and ultrasensitive photodetectors.

Geology of the Southern Guadalupe Mountains, Texas

USGS Publications Warehouse

King, Philip B.

1948-01-01

This report deals with an area of 425 square miles in the western part of Texas, immediately south of the New Mexico line. The area comprises the south end of the Guadalupe Mountains and the adjacent part of the Delaware Mountains; it includes the highest peaks in the State of Texas. The area is a segment of a large mountain mass that extends 50 miles or more northward and southward. The report describes the geology of the area, that is, the nature of its rocks, tectonics, and surface features, and the evidence that they give as to the evolution of the area through geologic time. Incidental reference is made to the geology of surrounding regions in order to place the area in its environment. The Permian system of the southwestern United States has been until recently one of the intriguing but little known subjects of American stratigraphy. In the latter half of the nineteenth century after the western. United States was settled, the "red bed" sections of the Permian were studied and reported on by many geologists, but up to 1920 the existence of a contemporaneous marine sequence in western Texas and southeastern New Mexico was little appreciated. Since that year the discovery of extensive oil fields and potash beds in this region gave an impetus to the study of the Permian rocks, and furnished the geologist with records of hundreds of drill holes from which to deduce the nature of the strata not exposed at the surface. At the same time geologists have studied the rocks in the outcropping areas, and have compared them with the strata encountered by drilling.Much remains to be done in order to understand the history of Permian time in the region. The physical and chemical conditions that caused. the deposition of .the various and often complexly related deposits need to be better understood. More of the fossils of the rich and interesting marine faunas should be described, and the relations of the fossils to their environments should be determined. Further, a satisfactory scheme of correlation is needed, and also a subdivision into series that will express the contemporaneity of strata in different areas. One useful contribution to the solution of these problems is the detailed study of sequences of rocks exposed at the surface in the different mountain ranges of Texas and New Mexico.This report deals with one such sequence of rocks in western Texas, the one exposed in the southern Guadalupe Mountains (fig. 1). Here, the Permian rocks are magnificently exposed, to a thickness of about 4,000 feet (pl. 1). They are all of marine origin, and belong to the middle part of the system, with the base concealed and the top absent. Overlying and underlying beds, however, are found in nearby areas.

Segmentation and additive approach: A reliable technique to study noncovalent interactions of large molecules at the surface of single-wall carbon nanotubes.

PubMed

Torres, Ana M; Scheiner, Steve; Roy, Ajit K; Garay-Tapia, Andrés M; Bustamante, John; Kar, Tapas

2016-08-05

This investigation explores a new protocol, named Segmentation and Additive approach (SAA), to study exohedral noncovalent functionalization of single-walled carbon nanotubes with large molecules, such as polymers and biomolecules, by segmenting the entire system into smaller units to reduce computational cost. A key criterion of the segmentation process is the preservation of the molecular structure responsible for stabilization of the entire system in smaller segments. Noncovalent interaction of linoleic acid (LA, C18 H32 O2 ), a fatty acid, at the surface of a (10,0) zigzag nanotube is considered for test purposes. Three smaller segmented models have been created from the full (10,0)-LA system and interaction energies were calculated for these models and compared with the full system at different levels of theory, namely ωB97XD, LDA. The success of this SAA is confirmed as the sum of the interaction energies is in very good agreement with the total interaction energy. Besides reducing computational cost, another merit of SAA is an estimation of the contributions from different sections of the large system to the total interaction energy which can be studied in-depth using a higher level of theory to estimate several properties of each segment. On the negative side, bulk properties, such as HOMO-LUMO (highest occupied molecular orbital - lowest occupied molecular orbital) gap, of the entire system cannot be estimated by adding results from segment models. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Estimates of Median Flows for Streams on the 1999 Kansas Surface Water Register

USGS Publications Warehouse

Perry, Charles A.; Wolock, David M.; Artman, Joshua C.

2004-01-01

The Kansas State Legislature, by enacting Kansas Statute KSA 82a?2001 et. seq., mandated the criteria for determining which Kansas stream segments would be subject to classification by the State. One criterion for the selection as a classified stream segment is based on the statistic of median flow being equal to or greater than 1 cubic foot per second. As specified by KSA 82a?2001 et. seq., median flows were determined from U.S. Geological Survey streamflow-gaging-station data by using the most-recent 10 years of gaged data (KSA) for each streamflow-gaging station. Median flows also were determined by using gaged data from the entire period of record (all-available hydrology, AAH). Least-squares multiple regression techniques were used, along with Tobit analyses, to develop equations for estimating median flows for uncontrolled stream segments. The drainage area of the gaging stations on uncontrolled stream segments used in the regression analyses ranged from 2.06 to 12,004 square miles. A logarithmic transformation of the data was needed to develop the best linear relation for computing median flows. In the regression analyses, the significant climatic and basin characteristics, in order of importance, were drainage area, mean annual precipitation, mean basin permeability, and mean basin slope. Tobit analyses of KSA data yielded a model standard error of prediction of 0.285 logarithmic units, and the best equations using Tobit analyses of AAH data had a model standard error of prediction of 0.250 logarithmic units. These regression equations and an interpolation procedure were used to compute median flows for the uncontrolled stream segments on the 1999 Kansas Surface Water Register. Measured median flows from gaging stations were incorporated into the regression-estimated median flows along the stream segments where available. The segments that were uncontrolled were interpolated using gaged data weighted according to the drainage area and the bias between the regression-estimated and gaged flow information. On controlled segments of Kansas streams, the median flow information was interpolated between gaging stations using only gaged data weighted by drainage area. Of the 2,232 total stream segments on the Kansas Surface Water Register, 34.5 percent of the segments had an estimated median streamflow of less than 1 cubic foot per second when the KSA analysis was used. When the AAH analysis was used, 36.2 percent of the segments had an estimated median streamflow of less than 1 cubic foot per second. This report supercedes U.S. Geological Survey Water-Resources Investigations Report 02?4292.

A simplified test for adhesive behavior in wood sections exposed to fire

Treesearch

E. L. Schaffer

1968-01-01

A relatively simple test procedure was developed to evaluate the behavior of various adhesives near fire-exposed surfaces in laminated constructions. A number of sections cut from laminated blocks were exposed to fire on one surface. After this exposure, the sections were transversely cut, and the gluelines were examined for separation depth. In addition, the cool...

Altered ulnar nerve kinematic behavior in a cadaver model of entrapment.

PubMed

Mahan, Mark A; Vaz, Kenneth M; Weingarten, David; Brown, Justin M; Shah, Sameer B

2015-06-01

Ulnar nerve entrapment at the elbow is more than a compressive lesion of the nerve. The tensile biomechanical consequences of entrapment are currently marginally understood. To evaluate the effects of tethering on the kinematics of the ulnar nerve as a model of entrapment neuropathy. The ulnar nerve was exposed in 7 fresh cadaver arms, and markers were placed at 1-cm increments along the nerve, centered on the retrocondylar region. Baseline translation (pure sliding) and strain (stretch) were measured in response to progressively increasing tension produced by varying configurations of elbow flexion and wrist extension. Then the nerves were tethered by suturing to the cubital tunnel retinaculum and again exposed to progressively increasing tension from joint positioning. In the native condition, for all joint configurations, the articular segment of the ulnar nerve exhibited greater strain than segments proximal and distal to the elbow, with a maximum strain of 28 ± 1% and translation of 11.6 ± 1.8 mm distally. Tethering the ulnar nerve suppressed translation, and the distal segment experienced strains that were more than 50% greater than its maximum strain in an untethered state. This work provides a framework for evaluating regional nerve kinematics. Suppressed translation due to tethering shifted the location of high strain from articular to more distal regions of the ulnar nerve. The authors hypothesize that deformation is thus shifted to a region of the nerve less accustomed to high strains, thereby contributing to the development of ulnar neuropathy.

Transfer of Dynamic Learning Across Postures

PubMed Central

Wolpert, Daniel M.

2009-01-01

When learning a difficult motor task, we often decompose the task so that the control of individual body segments is practiced in isolation. But on re-composition, the combined movements can result in novel and possibly complex internal forces between the body segments that were not experienced (or did not need to be compensated for) during isolated practice. Here we investigate whether dynamics learned in isolation by one part of the body can be used by other parts of the body to immediately predict and compensate for novel forces between body segments. Subjects reached to targets while holding the handle of a robotic, force-generating manipulandum. One group of subjects was initially exposed to the novel robot dynamics while seated and was then tested in a standing position. A second group was tested in the reverse order: standing then sitting. Both groups adapted their arm dynamics to the novel environment, and this movement learning transferred between seated and standing postures and vice versa. Both groups also generated anticipatory postural adjustments when standing and exposed to the force field for several trials. In the group that had learned the dynamics while seated, the appropriate postural adjustments were observed on the very first reach on standing. These results suggest that the CNS can immediately anticipate the effect of learned movement dynamics on a novel whole-body posture. The results support the existence of separate mappings for posture and movement, which encode similar dynamics but can be adapted independently. PMID:19710374

Space Weathering of Lunar Rocks

NASA Technical Reports Server (NTRS)

Noble, S. K.; Keller, L. P.; Christoffersen, R.; Rahman, Z.

2012-01-01

All materials exposed at the lunar surface undergo space weathering processes. On the Moon, boulders make up only a small percentage of the exposed surface, and areas where such rocks are exposed, like central peaks, are often among the least space weathered regions identified from remote sensing data. Yet space weathered surfaces (patina) are relatively common on returned rock samples, some of which directly sample the surface of larger boulders. Because, as witness plates to lunar space weathering, rocks and boulders experience longer exposure times compared to lunar soil grains, they allow us to develop a deeper perspective on the relative importance of various weathering processes as a function of time.

Pulmonary lobe segmentation based on ridge surface sampling and shape model fitting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ross, James C., E-mail: jross@bwh.harvard.edu; Surgical Planning Lab, Brigham and Women's Hospital, Boston, Massachusetts 02215; Laboratory of Mathematics in Imaging, Brigham and Women's Hospital, Boston, Massachusetts 02126

2013-12-15

Purpose: Performing lobe-based quantitative analysis of the lung in computed tomography (CT) scans can assist in efforts to better characterize complex diseases such as chronic obstructive pulmonary disease (COPD). While airways and vessels can help to indicate the location of lobe boundaries, segmentations of these structures are not always available, so methods to define the lobes in the absence of these structures are desirable. Methods: The authors present a fully automatic lung lobe segmentation algorithm that is effective in volumetric inspiratory and expiratory computed tomography (CT) datasets. The authors rely on ridge surface image features indicating fissure locations and amore » novel approach to modeling shape variation in the surfaces defining the lobe boundaries. The authors employ a particle system that efficiently samples ridge surfaces in the image domain and provides a set of candidate fissure locations based on the Hessian matrix. Following this, lobe boundary shape models generated from principal component analysis (PCA) are fit to the particles data to discriminate between fissure and nonfissure candidates. The resulting set of particle points are used to fit thin plate spline (TPS) interpolating surfaces to form the final boundaries between the lung lobes. Results: The authors tested algorithm performance on 50 inspiratory and 50 expiratory CT scans taken from the COPDGene study. Results indicate that the authors' algorithm performs comparably to pulmonologist-generated lung lobe segmentations and can produce good results in cases with accessory fissures, incomplete fissures, advanced emphysema, and low dose acquisition protocols. Dice scores indicate that only 29 out of 500 (5.85%) lobes showed Dice scores lower than 0.9. Two different approaches for evaluating lobe boundary surface discrepancies were applied and indicate that algorithm boundary identification is most accurate in the vicinity of fissures detectable on CT. Conclusions: The proposed algorithm is effective for lung lobe segmentation in absence of auxiliary structures such as vessels and airways. The most challenging cases are those with mostly incomplete, absent, or near-absent fissures and in cases with poorly revealed fissures due to high image noise. However, the authors observe good performance even in the majority of these cases.« less

Detection of white spot lesions by segmenting laser speckle images using computer vision methods.

PubMed

Gavinho, Luciano G; Araujo, Sidnei A; Bussadori, Sandra K; Silva, João V P; Deana, Alessandro M

2018-05-05

This paper aims to develop a method for laser speckle image segmentation of tooth surfaces for diagnosis of early stages caries. The method, applied directly to a raw image obtained by digital photography, is based on the difference between the speckle pattern of a carious lesion tooth surface area and that of a sound area. Each image is divided into blocks which are identified in a working matrix by their χ 2 distance between block histograms of the analyzed image and the reference histograms previously obtained by K-means from healthy (h_Sound) and lesioned (h_Decay) areas, separately. If the χ 2 distance between a block histogram and h_Sound is greater than the distance to h_Decay, this block is marked as decayed. The experiments showed that the method can provide effective segmentation for initial lesions. We used 64 images to test the algorithm and we achieved 100% accuracy in segmentation. Differences between the speckle pattern of a sound tooth surface region and a carious region, even in the early stage, can be evidenced by the χ 2 distance between histograms. This method proves to be more effective for segmenting the laser speckle image, which enhances the contrast between sound and lesioned tissues. The results were obtained with low computational cost. The method has the potential for early diagnosis in a clinical environment, through the development of low-cost portable equipment.

Minimally Invasive Exposure of the Maxillary Artery at the Anteromedial Infratemporal Fossa.

PubMed

Rodriguez Rubio, Roberto; Kola, Olivia; Tayebi Meybodi, Ali; Tabani, Halima; Feng, Xuequan; Burkhardt, Jan-Karl; Yousef, Sonia; Lawton, Michael T; Benet, Arnau

2018-04-12

The maxillary artery (MA) has been described as a reliable donor for extracranial-intracranial high-flow bypass. Existing techniques to harvest MA require brain retraction and drilling of the middle fossa (with or without a zygomatic osteotomy), carrying the potential risks of venous bleeding, injury to the branches of the maxillary or mandibular nerves, muscular transection, or temporomandibular junction disorders. To describe a novel technique to expose the MA without bony drilling and with minimal impact to surrounding structures. A conventional curvilinear incision was performed in 10 cadaveric specimens, prior to elevating the scalp to expose the zygomatic root and lateral orbital rim. The sphenozygomatic suture was followed to the anterolateral edge of the inferior orbital fissure (IOF) to locate and harvest the pterygoid segment of the MA. Topographic anatomy was assessed using surrounding landmarks and 3D Cartesian coordinates to define the surgical area. The number of visible MA branches and their lengths were recorded. The MA was successfully exposed in all specimens. This approach allowed 6 branches of MA to be exposed. The average length of exposure was 23.3 ± 8.3 mm and the average surgical area was 2.8 ± 0.9 cm2. The IOF was 11.5 ± 4.2 mm from the MA. Our technique provides landmarks to identify the distal pterygoid segment of MA as a donor for extracranial-intracranial bypasses without the need for additional craniectomies. Clear anatomical landmarks, including the sphenozygomatic suture, anterolateral edge of IOF, infraorbital artery, and the pterygomaxillary fissure defined a trajectory to efficiently localize the MA with minimal risk to surrounding structures.

Physical processes of shallow mafic dike emplacement near the San Rafael Swell, Utah

USGS Publications Warehouse

Delaney, P.T.; Gartner, A.E.

1997-01-01

Some 200 shonkinite dikes, sills, and breccia bodies on the western Colorado Plateau of south-central Utah were intruded from approximately 3.7 to 4.6 Ma, contemporaneous with mafic volcanism along the nearby plateau margin. Thicknesses of dikes range to about 6 m; the log-normal mean thickness is 85 cm. Despite the excellent exposures of essentially all dikes in strata of the Jurassic San Rafael Group, their number is indeterminate from their outcrop and spacing because they are everywhere greatly segmented. By our grouping of almost 2000 dike segments, most dikes are less than 2 km in outcrop length; the longest is 9 km. Because the San Rafael magmas were primitive and probably ascended directly from the mantle, dike lengths in outcrop are much less than their heights. The present exposures probably lie along the irregular upper peripheries of dikes that lengthen and merge with depth. Orientations of steps on dike contacts record local directions of dike-fracture propagation; about half of the measurements plunge less than 30??, showing that lateral propagation at dike peripheries is as important as the vertical propagation ultimately responsible for ascent. The San Rafael dikes, now exposed after erosion of about 0.5-1.5 km, appear to thicken and shorten upward, probably because near-surface vesiculation enhanced magmatic driving pressures. Propagation likely ceased soon after the first dike segments began to feed nearby sills or vented to initiate small-volume eruptions. Most of the dikes are exposed in clastic strata of the Jurassic San Rafael Group. They probably acquired their strikes, however, while ascending along well-developed joints in massive sandstones of the underlying Glen Canyon Group. Rotation of far-field stresses during the emplacement interval cannot account for disparate strikes of the dikes, which vary through 110??, most lying between north and N25??W. Rather, the two regional horizontal principal stresses were probably nearly equal, and so the dominant N75??E direction of dike opening was not strongly favored. Across the center of the swarm, about 10 to 15 dikes overlap and produce 15-20 m of dilation. Many are in sufficient proximity that later dikes should be thinner than earlier ones if neither the magma pressures nor regional stresses were changing during the emplacement interval. However, dike thicknesses vary systematically neither along the length of the swarm nor in proportion to the number of neighboring dikes. It appears that crustal extension during the maginatic interval relieved compressive stresses localized by intrusion.

Synthesis, surface characterization, and biointeraction studies of low-surface energy side-chain polyetherurethanes

NASA Astrophysics Data System (ADS)

Porter, Stephen Christopher

1999-10-01

New segmented polyetherurethanes (PEUs) with low surface energy hydrocarbon and fluorocarbon side-chains attached to the polymer hard segments were synthesized. The surface chemistry of solvent cast polymer films was studied using X-ray photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry, and dynamic contact angle (DCA) measurements. Increases in the overall density and length of the alkyl side-chains within the PEUs resulted in greater side-chain concentrations at the polymer surface. PEUs bearing long alkyl (> C10 ) and perfluorocarbon side-chains were found to posses surfaces with highly enriched side-chain concentrations relative to the bulk polymer. In PEUs with significant side-chain surface enrichment, the relatively polar hard segment blocks were shown to reside in high concentrations just below the side-chain enriched surface layer. Furthermore, DCA measurements demonstrated that the surface of the alkyl side-chain PEUs did not undergo significant rearrangement when placed into an aqueous environment, whereas the surface of a hard segment model polymer bearing C18 sidechains (PEU-C18-HS) did. Hydrogen bonding within the PEUs was examined using FTIR and was shown to be disrupted by the addition of side-chains; an effect dependent on the density but not on the length of the side-chains. Heteropolymer blends comprised of mixtures of high side-chain density and side-chain free PEUs were compared with homopolymers having the same overall side-chain concentration as the blends. Significantly more surface enrichment of side-chains was found in the heteropolymer blends whereas hydrogen bonding nearly the same as in the homopolymers. Adsorption of native and delipidized human serum albumin (HSA) from pure solution and blood plasma; the elutabilty of adsorbed HSA; and static platelet adhesion to plasma preadsorbed surfaces, were all examined on alkyl side-chain PEUs. Several polymers with high C18 side-chain densities displayed increased affinity for albumin, and reduced elutability. Among these, PEU-C18-HS demonstrated a significant reduction in platelet adhesion at low plasma pre-adsorption concentrations. However, competitive binary adsorption of fibrinogen in the presence of HSA demonstrated lower relative albumin affinity for PEU-C18-HS than other PEUs. The observed effects are thought to be mainly a result of increased surface hydrophobicity of the alkyl-side chain modified PEU, and not high specificity albumin binding.

Joint multi-object registration and segmentation of left and right cardiac ventricles in 4D cine MRI

NASA Astrophysics Data System (ADS)

Ehrhardt, Jan; Kepp, Timo; Schmidt-Richberg, Alexander; Handels, Heinz

2014-03-01

The diagnosis of cardiac function based on cine MRI requires the segmentation of cardiac structures in the images, but the problem of automatic cardiac segmentation is still open, due to the imaging characteristics of cardiac MR images and the anatomical variability of the heart. In this paper, we present a variational framework for joint segmentation and registration of multiple structures of the heart. To enable the simultaneous segmentation and registration of multiple objects, a shape prior term is introduced into a region competition approach for multi-object level set segmentation. The proposed algorithm is applied for simultaneous segmentation of the myocardium as well as the left and right ventricular blood pool in short axis cine MRI images. Two experiments are performed: first, intra-patient 4D segmentation with a given initial segmentation for one time-point in a 4D sequence, and second, a multi-atlas segmentation strategy is applied to unseen patient data. Evaluation of segmentation accuracy is done by overlap coefficients and surface distances. An evaluation based on clinical 4D cine MRI images of 25 patients shows the benefit of the combined approach compared to sole registration and sole segmentation.

Analytical study on a two-dimensional plane of the off-design flow properties of tandem-bladed compressor stators

NASA Technical Reports Server (NTRS)

Sanger, N. L.

1973-01-01

The flow characteristics of several tandem bladed compressor stators were analytically evaluated over a range of inlet incidence angles. The ratios of rear-segment to front-segment chord and camber were varied. Results were also compared to the analytical performance of a reference solid blade section. All tandem blade sections exhibited lower calculated losses than the solid stator. But no one geometric configuration exhibited clearly superior characteristics. The front segment accepts the major effect of overall incidence angle change. Rear- to front-segment camber ratios of 4 and greater appeared to be limited by boundary-layer separation from the pressure surface of the rear segment.

SAR image segmentation using skeleton-based fuzzy clustering

NASA Astrophysics Data System (ADS)

Cao, Yun Yi; Chen, Yan Qiu

2003-06-01

SAR image segmentation can be converted to a clustering problem in which pixels or small patches are grouped together based on local feature information. In this paper, we present a novel framework for segmentation. The segmentation goal is achieved by unsupervised clustering upon characteristic descriptors extracted from local patches. The mixture model of characteristic descriptor, which combines intensity and texture feature, is investigated. The unsupervised algorithm is derived from the recently proposed Skeleton-Based Data Labeling method. Skeletons are constructed as prototypes of clusters to represent arbitrary latent structures in image data. Segmentation using Skeleton-Based Fuzzy Clustering is able to detect the types of surfaces appeared in SAR images automatically without any user input.

Method for fabricating boron carbide articles

DOEpatents

Ardary, Zane L.; Reynolds, Carl D.

1980-01-01

The present invention is directed to the fabrication of boron carbide articles having length-to-diameter or width ratios greater than 2 to 1. The process of the present invention is practiced by the steps comprising hot pressing boron carbide powder into article segments or portions in which the segments have a length-to-diameter or width ratio less than 1.5, aligning a plurality of the initially hot-pressed segments in a hot-pressing die with the end surfaces of the segments placed in intimate contact with one another, and then hot pressing the aligned segments into an article of the desired configuration. The resulting article exhibits essentially uniform density throughout the structure with the bonds between the segments being equivalent in hardness, strength, and density to the remainder of the article.

Complementary Ruptures of Surface Ruptures and Deep Asperity during the 2014 Northern Nagano, Japan, Earthquake (MW 6.3)

NASA Astrophysics Data System (ADS)

Asano, K.; Iwata, T.; Kubo, H.

2015-12-01

A thrust earthquake of MW 6.3 occurred along the northern part of the Itoigawa-Shizuoka Tectonic Line (ISTL) in the northern Nagano prefecture, central Japan, on November 22, 2014. This event was reported to be related to an active fault, the Kamishiro fault belonging to the ISTL (e.g., HERP, 2014). The surface rupture is observed along the Kamishiro fault (e.g., Lin et al., 2015; Okada et al., 2015). We estimated the kinematic source rupture process of this earthquake through the multiple time-window linear waveform inversion method (Hartzell and Heaton, 1983). We used velocity waveforms in 0.05-1 Hz from 12 strong motion stations of K-NET, KiK-net (NIED), JMA, and Nagano prefecture (SK-net, ERI). In order to enhance the reliability in Green's functions, we assumed one-dimensional velocity structure models different for the different stations, which were extracted from the nation-wide three-dimensional velocity structure model, Japan Integrated Velocity Structure Model (JIVSM, Koketsu et al., 2012). Considering the spatial distribution of aftershocks (Sakai et al., 2015) and surface ruptures, the assumed fault model consisted of two dip-bending fault segments with different dip angles between the northern and southern segments. The total length and width of the fault plane is 20 km and 13 km, relatively, and the fault model is divided into 260 subfaults of 1 km × 1 km in space and six smoothed ramp functions in time. An asperity or large slip area with a peak slip of 1.9 m was estimated in the lower plane of the northern segment in the approximate depth range of 4 to 8 km. The depth extent of this asperity is consistent with the seismogenic zone revealed by past studies (e.g., Panayotopoulos et al., 2014). In contrast, the slip in the southern segment is relatively concentrated in the shallow portion of the segment where the surface ruptures were found along the Kamishiro fault. The overall spatial rupture pattern of the source fault, in which the deep asperity was located on the northern segment and surface rupture was found on the southern segment, seems to be spatially consistent with the mapped active faults. These findings suggest characteristic and repeating features of fault ruptures along active faults where static offsets have accumulated over past events, and it would be a good constraint on earthquake scenarios along it.

Expression and putative function of fibronectin and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro.

PubMed

Thys, Mirjan; Nauwynck, Hans; Maes, Dominiek; Hoogewijs, Maarten; Vercauteren, Dries; Rijsselaere, Tom; Favoreel, Herman; Van Soom, Ann

2009-09-01

Fibronectin (Fn) is a 440 kDa glycoprotein assumed to participate in sperm-egg interaction in human. Recently, it has been demonstrated that Fn--when present during bovine IVF--strongly inhibits sperm penetration. The present study was conducted firstly to evaluate the expression of Fn and its integrin receptor (alpha(5)beta(1)) on male and female bovine gametes using indirect immunofluorescence and secondly, to determine the function of Fn during bovine IVF. Endogenous Fn was detected underneath the zona pellucida (ZP) and integrin alpha(5) on the oolemma of cumulus-denuded oocytes. Bovine spermatozoa displayed integrin alpha(5) at their equatorial segment after acrosome reaction. We established that the main inhibitory effect of exogenously supplemented Fn was located at the sperm-oolemma binding, with a (concurrent) effect on fusion, and this can probably be attributed to the binding of Fn to spermatozoa at the equatorial segment, as shown by means of Alexa Fluor 488-conjugated Fn. Combining these results, the inhibitory effect of exogenously supplemented Fn seemed to be exerted on the male gamete by binding to the exposed integrin alpha(5)beta(1) receptor after acrosome reaction. The presence of endogenous Fn underneath the ZP together with integrin alpha(5) expression on oolemma and acrosome-reacted (AR) sperm cell surface suggests a 'velcro' interaction between the endogenous Fn ligand and corresponding receptors on both (AR) sperm cell and oolemma, initiating sperm-egg binding.

Highly Segmented Thermal Barrier Coatings Deposited by Suspension Plasma Spray: Effects of Spray Process on Microstructure

NASA Astrophysics Data System (ADS)

Chen, Xiaolong; Honda, Hiroshi; Kuroda, Seiji; Araki, Hiroshi; Murakami, Hideyuki; Watanabe, Makoto; Sakka, Yoshio

2016-12-01

Effects of the ceramic powder size used for suspension as well as several processing parameters in suspension plasma spraying of YSZ were investigated experimentally, aiming to fabricate highly segmented microstructures for thermal barrier coating (TBC) applications. Particle image velocimetry (PIV) was used to observe the atomization process and the velocity distribution of atomized droplets and ceramic particles travelling toward the substrates. The tested parameters included the secondary plasma gas (He versus H2), suspension injection flow rate, and substrate surface roughness. Results indicated that a plasma jet with a relatively higher content of He or H2 as the secondary plasma gas was critical to produce highly segmented YSZ TBCs with a crack density up to 12 cracks/mm. The optimized suspension flow rate played an important role to realize coatings with a reduced porosity level and improved adhesion. An increased powder size and higher operation power level were beneficial for the formation of highly segmented coatings onto substrates with a wider range of surface roughness.

Multi-Segment Radius Measurement Using an Absolute Distance Meter Through a Null Assembly

NASA Technical Reports Server (NTRS)

Merle, Cormic; Wick, Eric; Hayden, Joseph

2011-01-01

This system was one of the test methods considered for measuring the radius of curvature of one or more of the 18 segmented mirrors that form the 6.5 m diameter primary mirror (PM) of the James Webb Space Telescope (JWST). The assembled telescope will be tested at cryogenic temperatures in a 17-m diameter by 27-m high vacuum chamber at the Johnson Space Center. This system uses a Leica Absolute Distance Meter (ADM), at a wavelength of 780 nm, combined with beam-steering and beam-shaping optics to make a differential distance measurement between a ring mirror on the reflective null assembly and individual PM segments. The ADM is located inside the same Pressure-Tight Enclosure (PTE) that houses the test interferometer. The PTE maintains the ADM and interferometer at ambient temperature and pressure so that they are not directly exposed to the telescope s harsh cryogenic and vacuum environment. This system takes advantage of the existing achromatic objective and reflective null assembly used by the test interferometer to direct four ADM beamlets to four PM segments through an optical path that is coincident with the interferometer beam. A mask, positioned on a linear slide, contains an array of 1.25 mm diameter circular subapertures that map to each of the 18 PM segments as well as six positions around the ring mirror. A down-collimated 4 mm ADM beam simultaneously covers 4 adjacent PM segment beamlets and one ring mirror beamlet. The radius, or spacing, of all 18 segments can be measured with the addition of two orthogonally-oriented scanning pentaprisms used to steer the ADM beam to any one of six different sub-aperture configurations at the plane of the ring mirror. The interferometer beam, at a wavelength of 687 nm, and the ADM beamlets, at a wavelength of 780 nm, pass through the objective and null so that the rays are normally incident on the parabolic PM surface. After reflecting off the PM, both the ADM and interferometer beams return to their respective instruments on nearly the same path. A fifth beamlet, acting as a differential reference, reflects off a ring mirror attached to the objective and null and returns to the ADM. The spacings between the ring mirror, objective, and null are known through manufacturing tolerances as well as through an in situ null wavefront alignment of the interferometer test beam with a reflective hologram located near the caustic of the null. Since total path length between the ring mirror and PM segments is highly deterministic, any ADM-measured departures from the predicted path length can be attributed to either spacing error or radius error in the PM. It is estimated that the path length measurement between the ring mirror and a PM segment is accurate to better than 100 m. The unique features of this invention include the differential distance measuring capability and its integration into an existing cryogenic and vacuum compatible interferometric optical test.

Design and Optimization of the SPOT Primary Mirror Segment

NASA Technical Reports Server (NTRS)

Budinoff, Jason G.; Michaels, Gregory J.

2005-01-01

The 3m Spherical Primary Optical Telescope (SPOT) will utilize a single ring of 0.86111 point-to-point hexagonal mirror segments. The f2.85 spherical mirror blanks will be fabricated by the same replication process used for mass-produced commercial telescope mirrors. Diffraction-limited phasing will require segment-to-segment radius of curvature (ROC) variation of approx.1 micron. Low-cost, replicated segment ROC variations are estimated to be almost 1 mm, necessitating a method for segment ROC adjustment & matching. A mechanical architecture has been designed that allows segment ROC to be adjusted up to 400 microns while introducing a minimum figure error, allowing segment-to-segment ROC matching. A key feature of the architecture is the unique back profile of the mirror segments. The back profile of the mirror was developed with shape optimization in MSC.Nastran(TradeMark) using optical performance response equations written with SigFit. A candidate back profile was generated which minimized ROC-adjustment-induced surface error while meeting the constraints imposed by the fabrication method. Keywords: optimization, radius of curvature, Pyrex spherical mirror, Sigfit

Weakly supervised automatic segmentation and 3D modeling of the knee joint from MR images

NASA Astrophysics Data System (ADS)

Amami, Amal; Ben Azouz, Zouhour

2013-12-01

Automatic segmentation and 3D modeling of the knee joint from MR images, is a challenging task. Most of the existing techniques require the tedious manual segmentation of a training set of MRIs. We present an approach that necessitates the manual segmentation of one MR image. It is based on a volumetric active appearance model. First, a dense tetrahedral mesh is automatically created on a reference MR image that is arbitrary selected. Second, a pairwise non-rigid registration between each MRI from a training set and the reference MRI is computed. The non-rigid registration is based on a piece-wise affine deformation using the created tetrahedral mesh. The minimum description length is then used to bring all the MR images into a correspondence. An average image and tetrahedral mesh, as well as a set of main modes of variations, are generated using the established correspondence. Any manual segmentation of the average MRI can be mapped to other MR images using the AAM. The proposed approach has the advantage of simultaneously generating 3D reconstructions of the surface as well as a 3D solid model of the knee joint. The generated surfaces and tetrahedral meshes present the interesting property of fulfilling a correspondence between different MR images. This paper shows preliminary results of the proposed approach. It demonstrates the automatic segmentation and 3D reconstruction of a knee joint obtained by mapping a manual segmentation of a reference image.

Digital Terrain from a Two-Step Segmentation and Outlier-Based Algorithm

NASA Astrophysics Data System (ADS)

Hingee, Kassel; Caccetta, Peter; Caccetta, Louis; Wu, Xiaoliang; Devereaux, Drew

2016-06-01

We present a novel ground filter for remotely sensed height data. Our filter has two phases: the first phase segments the DSM with a slope threshold and uses gradient direction to identify candidate ground segments; the second phase fits surfaces to the candidate ground points and removes outliers. Digital terrain is obtained by a surface fit to the final set of ground points. We tested the new algorithm on digital surface models (DSMs) for a 9600km2 region around Perth, Australia. This region contains a large mix of land uses (urban, grassland, native forest and plantation forest) and includes both a sandy coastal plain and a hillier region (elevations up to 0.5km). The DSMs are captured annually at 0.2m resolution using aerial stereo photography, resulting in 1.2TB of input data per annum. Overall accuracy of the filter was estimated to be 89.6% and on a small semi-rural subset our algorithm was found to have 40% fewer errors compared to Inpho's Match-T algorithm.

SU-C-BRA-06: Automatic Brain Tumor Segmentation for Stereotactic Radiosurgery Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Y; Stojadinovic, S; Jiang, S

Purpose: Stereotactic radiosurgery (SRS), which delivers a potent dose of highly conformal radiation to the target in a single fraction, requires accurate tumor delineation for treatment planning. We present an automatic segmentation strategy, that synergizes intensity histogram thresholding, super-voxel clustering, and level-set based contour evolving methods to efficiently and accurately delineate SRS brain tumors on contrast-enhance T1-weighted (T1c) Magnetic Resonance Images (MRI). Methods: The developed auto-segmentation strategy consists of three major steps. Firstly, tumor sites are localized through 2D slice intensity histogram scanning. Then, super voxels are obtained through clustering the corresponding voxels in 3D with reference to the similaritymore » metrics composited from spatial distance and intensity difference. The combination of the above two could generate the initial contour surface. Finally, a localized region active contour model is utilized to evolve the surface to achieve the accurate delineation of the tumors. The developed method was evaluated on numerical phantom data, synthetic BRATS (Multimodal Brain Tumor Image Segmentation challenge) data, and clinical patients’ data. The auto-segmentation results were quantitatively evaluated by comparing to ground truths with both volume and surface similarity metrics. Results: DICE coefficient (DC) was performed as a quantitative metric to evaluate the auto-segmentation in the numerical phantom with 8 tumors. DCs are 0.999±0.001 without noise, 0.969±0.065 with Rician noise and 0.976±0.038 with Gaussian noise. DC, NMI (Normalized Mutual Information), SSIM (Structural Similarity) and Hausdorff distance (HD) were calculated as the metrics for the BRATS and patients’ data. Assessment of BRATS data across 25 tumor segmentation yield DC 0.886±0.078, NMI 0.817±0.108, SSIM 0.997±0.002, and HD 6.483±4.079mm. Evaluation on 8 patients with total 14 tumor sites yield DC 0.872±0.070, NMI 0.824±0.078, SSIM 0.999±0.001, and HD 5.926±6.141mm. Conclusion: The developed automatic segmentation strategy, which yields accurate brain tumor delineation in evaluation cases, is promising for its application in SRS treatment planning.« less

Real time automated inspection

DOEpatents

Fant, Karl M.; Fundakowski, Richard A.; Levitt, Tod S.; Overland, John E.; Suresh, Bindinganavle R.; Ulrich, Franz W.

1985-01-01

A method and apparatus relating to the real time automatic detection and classification of characteristic type surface imperfections occurring on the surfaces of material of interest such as moving hot metal slabs produced by a continuous steel caster. A data camera transversely scans continuous lines of such a surface to sense light intensities of scanned pixels and generates corresponding voltage values. The voltage values are converted to corresponding digital values to form a digital image of the surface which is subsequently processed to form an edge-enhanced image having scan lines characterized by intervals corresponding to the edges of the image. The edge-enhanced image is thresholded to segment out the edges and objects formed by the edges are segmented out by interval matching and bin tracking. Features of the objects are derived and such features are utilized to classify the objects into characteristic type surface imperfections.

Simulation on turning aspheric surface method via oscillating feed

NASA Astrophysics Data System (ADS)

Kong, Fanxing; Li, Zengqiang; Sun, Tao

2014-08-01

It is quite difficult to manufacturing optical components, the combination of high gradient ellipsoid and hyperboloid, with high machining surface requirements. To solve the problem, in this paper we present a turning and forming method via oscillating feed of R-θ layout lathe, analyze machining ellipsoid segment and hyperboloid segment separately through oscillating feed. Also calculate parameters on each trajectory during processing respectively and obtain displacement, velocity, acceleration and other parameters. The simulation result shows that this rotary turning method is capable of ensuring that the cutter is on the equidistance line of meridian cross section curve of work piece during processing high gradient aspheric surface, which helps getting high quality surface. Also the method provides a new approach and a theory basis for manufacturing high quality aspheric surface and extending function of the available twin-spindle lathe as well.

Physics-Based Image Segmentation Using First Order Statistical Properties and Genetic Algorithm for Inductive Thermography Imaging.

PubMed

Gao, Bin; Li, Xiaoqing; Woo, Wai Lok; Tian, Gui Yun

2018-05-01

Thermographic inspection has been widely applied to non-destructive testing and evaluation with the capabilities of rapid, contactless, and large surface area detection. Image segmentation is considered essential for identifying and sizing defects. To attain a high-level performance, specific physics-based models that describe defects generation and enable the precise extraction of target region are of crucial importance. In this paper, an effective genetic first-order statistical image segmentation algorithm is proposed for quantitative crack detection. The proposed method automatically extracts valuable spatial-temporal patterns from unsupervised feature extraction algorithm and avoids a range of issues associated with human intervention in laborious manual selection of specific thermal video frames for processing. An internal genetic functionality is built into the proposed algorithm to automatically control the segmentation threshold to render enhanced accuracy in sizing the cracks. Eddy current pulsed thermography will be implemented as a platform to demonstrate surface crack detection. Experimental tests and comparisons have been conducted to verify the efficacy of the proposed method. In addition, a global quantitative assessment index F-score has been adopted to objectively evaluate the performance of different segmentation algorithms.

Polymer dynamics under cylindrical confinement featuring a locally repulsive surface: A quasielastic neutron scattering study.

PubMed

Krutyeva, M; Pasini, S; Monkenbusch, M; Allgaier, J; Maiz, J; Mijangos, C; Hartmann-Azanza, B; Steinhart, M; Jalarvo, N; Richter, D

2017-05-28

We investigated the effect of intermediate cylindrical confinement with locally repulsive walls on the segmental and entanglement dynamics of a polymer melt by quasielastic neutron scattering. As a reference, the corresponding polymer melt was measured under identical conditions. The locally repulsive confinement was realized by hydrophilic anodic alumina nanopores with a diameter of 20 nm. The end-to-end distance of the hydrophobic infiltrated polyethylene-alt-propylene was close to this diameter. In the case of hard wall repulsion with negligible local attraction, several simulations predicted an acceleration of segmental dynamics close to the wall. Other than in attractive or neutral systems, where the segmental dynamics is slowed down, we found that the segmental dynamics in the nanopores is identical to the local mobility in the bulk. Even under very careful scrutiny, we could not find any acceleration of the surface-near segmental motion. On the larger time scale, the neutron spin-echo experiment showed that the Rouse relaxation was not altered by confinement effects. Also the entanglement dynamics was not affected. Thus at moderate confinement conditions, facilitated by locally repulsive walls, the dynamics remains as in the bulk melt, a result that is not so clear from simulations.

Advanced two-layer level set with a soft distance constraint for dual surfaces segmentation in medical images

NASA Astrophysics Data System (ADS)

Ji, Yuanbo; van der Geest, Rob J.; Nazarian, Saman; Lelieveldt, Boudewijn P. F.; Tao, Qian

2018-03-01

Anatomical objects in medical images very often have dual contours or surfaces that are highly correlated. Manually segmenting both of them by following local image details is tedious and subjective. In this study, we proposed a two-layer region-based level set method with a soft distance constraint, which not only regularizes the level set evolution at two levels, but also imposes prior information on wall thickness in an effective manner. By updating the level set function and distance constraint functions alternatingly, the method simultaneously optimizes both contours while regularizing their distance. The method was applied to segment the inner and outer wall of both left atrium (LA) and left ventricle (LV) from MR images, using a rough initialization from inside the blood pool. Compared to manual annotation from experience observers, the proposed method achieved an average perpendicular distance (APD) of less than 1mm for the LA segmentation, and less than 1.5mm for the LV segmentation, at both inner and outer contours. The method can be used as a practical tool for fast and accurate dual wall annotations given proper initialization.

A new method for automated discontinuity trace mapping on rock mass 3D surface model

NASA Astrophysics Data System (ADS)

Li, Xiaojun; Chen, Jianqin; Zhu, Hehua

2016-04-01

This paper presents an automated discontinuity trace mapping method on a 3D surface model of rock mass. Feature points of discontinuity traces are first detected using the Normal Tensor Voting Theory, which is robust to noisy point cloud data. Discontinuity traces are then extracted from feature points in four steps: (1) trace feature point grouping, (2) trace segment growth, (3) trace segment connection, and (4) redundant trace segment removal. A sensitivity analysis is conducted to identify optimal values for the parameters used in the proposed method. The optimal triangular mesh element size is between 5 cm and 6 cm; the angle threshold in the trace segment growth step is between 70° and 90°; the angle threshold in the trace segment connection step is between 50° and 70°, and the distance threshold should be at least 15 times the mean triangular mesh element size. The method is applied to the excavation face trace mapping of a drill-and-blast tunnel. The results show that the proposed discontinuity trace mapping method is fast and effective and could be used as a supplement to traditional direct measurement of discontinuity traces.

Automatic Approach for Lung Segmentation with Juxta-Pleural Nodules from Thoracic CT Based on Contour Tracing and Correction.

PubMed

Wang, Jinke; Guo, Haoyan

2016-01-01

This paper presents a fully automatic framework for lung segmentation, in which juxta-pleural nodule problem is brought into strong focus. The proposed scheme consists of three phases: skin boundary detection, rough segmentation of lung contour, and pulmonary parenchyma refinement. Firstly, chest skin boundary is extracted through image aligning, morphology operation, and connective region analysis. Secondly, diagonal-based border tracing is implemented for lung contour segmentation, with maximum cost path algorithm used for separating the left and right lungs. Finally, by arc-based border smoothing and concave-based border correction, the refined pulmonary parenchyma is obtained. The proposed scheme is evaluated on 45 volumes of chest scans, with volume difference (VD) 11.15 ± 69.63 cm 3 , volume overlap error (VOE) 3.5057 ± 1.3719%, average surface distance (ASD) 0.7917 ± 0.2741 mm, root mean square distance (RMSD) 1.6957 ± 0.6568 mm, maximum symmetric absolute surface distance (MSD) 21.3430 ± 8.1743 mm, and average time-cost 2 seconds per image. The preliminary results on accuracy and complexity prove that our scheme is a promising tool for lung segmentation with juxta-pleural nodules.

High pressure capillary connector

DOEpatents

Renzi, Ronald F.

2005-08-09

A high pressure connector capable of operating at pressures of 40,000 psi or higher is provided. This connector can be employed to position a first fluid-bearing conduit that has a proximal end and a distal end to a second fluid-bearing conduit thereby providing fluid communication between the first and second fluid-bearing conduits. The connector includes (a) an internal fitting assembly having a body cavity with (i) a lower segment that defines a lower segment aperture and (ii) an interiorly threaded upper segment, (b) a first member having a first member aperture that traverses its length wherein the first member aperture is configured to accommodate the first fluid-bearing conduit and wherein the first member is positioned in the lower segment of the internal fitting assembly, and (c) a second member having a second member aperture that traverses its length wherein the second member is positioned in the upper segment of the fitting assembly and wherein a lower surface of the second member is in contact with an upper surface of the first member to assert a compressive force onto the first member and wherein the first member aperture and the second member aperture are coaxial.

Polymer dynamics under cylindrical confinement featuring a locally repulsive surface: A quasielastic neutron scattering study

NASA Astrophysics Data System (ADS)

Krutyeva, M.; Pasini, S.; Monkenbusch, M.; Allgaier, J.; Maiz, J.; Mijangos, C.; Hartmann-Azanza, B.; Steinhart, M.; Jalarvo, N.; Richter, D.

2017-05-01

We investigated the effect of intermediate cylindrical confinement with locally repulsive walls on the segmental and entanglement dynamics of a polymer melt by quasielastic neutron scattering. As a reference, the corresponding polymer melt was measured under identical conditions. The locally repulsive confinement was realized by hydrophilic anodic alumina nanopores with a diameter of 20 nm. The end-to-end distance of the hydrophobic infiltrated polyethylene-alt-propylene was close to this diameter. In the case of hard wall repulsion with negligible local attraction, several simulations predicted an acceleration of segmental dynamics close to the wall. Other than in attractive or neutral systems, where the segmental dynamics is slowed down, we found that the segmental dynamics in the nanopores is identical to the local mobility in the bulk. Even under very careful scrutiny, we could not find any acceleration of the surface-near segmental motion. On the larger time scale, the neutron spin-echo experiment showed that the Rouse relaxation was not altered by confinement effects. Also the entanglement dynamics was not affected. Thus at moderate confinement conditions, facilitated by locally repulsive walls, the dynamics remains as in the bulk melt, a result that is not so clear from simulations.

Chemical stabilization of graphite surfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bistrika, Alexander A.; Lerner, Michael M.

Embodiments of a device, or a component of a device, including a stabilized graphite surface, methods of stabilizing graphite surfaces, and uses for the devices or components are disclosed. The device or component includes a surface comprising graphite, and a plurality of haloaryl ions and/or haloalkyl ions bound to at least a portion of the graphite. The ions may be perhaloaryl ions and/or perhaloalkyl ions. In certain embodiments, the ions are perfluorobenzenesulfonate anions. Embodiments of the device or component including stabilized graphite surfaces may maintain a steady-state oxidation or reduction surface current density after being exposed to continuous oxidation conditionsmore » for a period of at least 1-100 hours. The device or component is prepared by exposing a graphite-containing surface to an acidic aqueous solution of the ions under oxidizing conditions. The device or component can be exposed in situ to the solution.« less

Design of equipment for lunar dust removal

NASA Technical Reports Server (NTRS)

Belden, Lacy; Cowan, Kevin; Kleespies, Hank; Ratliff, Ryan; Shah, Oniell; Shelburne, Kevin

1991-01-01

NASA has a long range goal of constructing a fully equipped, manned lunar base on the near side of the moon by the year 2015. During the Apollo Missions, lunar dust coated and fouled equipment surfaces and mechanisms exposed to the lunar environment. In addition, the atmosphere and internal surfaces of the lunar excursion module were contaminated by lunar dust which was brought in on articles passed through the airlock. Consequently, the need exists for device or appliance to remove lunar dust from surfaces of material objects used outside of the proposed lunar habitat. Additionally, several concepts were investigated for preventing the accumulation of lunar dust on mechanisms and finished surfaces. The character of the dust and the lunar environment present unique challenges for the removal of contamination from exposed surfaces. In addition to a study of lunar dust adhesion properties, the project examines the use of various energy domains for removing the dust from exposed surfaces. Also, prevention alternatives are examined for systems exposed to lunar dust. A concept utilizing a pressurized gas is presented for dust removal outside of an atmospherically controlled environment. The concept consists of a small astronaut/robotic compatible device which removes dust from contaminated surfaces by a small burst of gas.

Constraints on behaviour of a mining‐induced earthquake inferred from laboratory rock mechanics experiments

USGS Publications Warehouse

McGarr, Arthur F.; Johnston, Malcolm J.; Boettcher, M.; Heesakkers, V.; Reches, Z.

2013-01-01

On December 12, 2004, an earthquake of magnitude 2.2, located in the TauTona Gold Mine at a depth of about 3.65 km in the ancient Pretorius fault zone, was recorded by the in-mine borehole seismic network, yielding an excellent set of ground motion data recorded at hypocentral distances of several km. From these data, the seismic moment tensor, indicating mostly normal faulting with a small implosive component, and the radiated energy were measured; the deviatoric component of the moment tensor was estimated to be M0 = 2.3×1012 N·m and the radiated energy ER = 5.4×108 J. This event caused extensive damage along tunnels within the Pretorius fault zone. What rendered this earthquake of particular interest was the underground investigation of the complex pattern of exposed rupture surfaces combined with laboratory testing of rock samples retrieved from the ancient fault zone (Heesakkers et al.2011a, 2011b). Event 12/12 2004 was the result of fault slip across at least four nonparallel fault surfaces; 25 mm of slip was measured at one location on the rupture segment that is most parallel with a fault plane inferred from the seismic moment tensor, suggesting that this segment accounted for much of the total seismic deformation. By applying a recently developed technique based on biaxial stick-slip friction experiments (McGarr2012, 2013) to the seismic results, together with the 25 mm slip observed underground, we estimated a maximum slip rate of at least 6.6 m/s, which is consistent with the observed damage to tunnels in the rupture zone. Similarly, the stress drop and apparent stress were found to be correspondingly high at 21.9 MPa and 6.6 MPa, respectively. The ambient state of stress, measured at the approximate depth of the earthquake but away from the influence of mining, in conjunction with laboratory measurements of the strength of the fault zone cataclasites, indicates that during rupture of the M 2.2 event, the normal stress acting on the large-slip fault segment was about 260 MPa, the yield stress was 172 MPa and the seismic efficiency was 0.05. Thus, for event 12/12 2004, 5% of the energy released by the earthquake was radiated and the remaining 95% was consumed in overcoming fault friction and expanding the zone of rupture.

Radio Frequency Ablation Registration, Segmentation, and Fusion Tool

PubMed Central

McCreedy, Evan S.; Cheng, Ruida; Hemler, Paul F.; Viswanathan, Anand; Wood, Bradford J.; McAuliffe, Matthew J.

2008-01-01

The Radio Frequency Ablation Segmentation Tool (RFAST) is a software application developed using NIH's Medical Image Processing Analysis and Visualization (MIPAV) API for the specific purpose of assisting physicians in the planning of radio frequency ablation (RFA) procedures. The RFAST application sequentially leads the physician through the steps necessary to register, fuse, segment, visualize and plan the RFA treatment. Three-dimensional volume visualization of the CT dataset with segmented 3D surface models enables the physician to interactively position the ablation probe to simulate burns and to semi-manually simulate sphere packing in an attempt to optimize probe placement. PMID:16871716

Interaction of Al with O2 exposed Mo2BC

NASA Astrophysics Data System (ADS)

Bolvardi, Hamid; Music, Denis; Schneider, Jochen M.

2015-03-01

A Mo2BC(0 4 0) surface was exposed to O2. The gas interaction was investigated using ab initio molecular dynamics and X-ray photoelectron spectroscopy (XPS) of air exposed surfaces. The calculations suggest that the most dominating physical mechanism is dissociative O2 adsorption whereby Mosbnd O, Osbnd Mosbnd O and Mo2sbnd Csbnd O bond formation is observed. To validate these results, Mo2BC thin films were synthesized utilizing high power pulsed magnetron sputtering and air exposed surfaces were probed by XPS. MoO2 and MoO3 bond formation is observed and is consistent with here obtained ab initio data. Additionally, the interfacial interactions of O2 exposed Mo2BC(0 4 0) surface with an Al nonamer is studied with ab initio molecular dynamics to describe on the atomic scale the interaction between this surface and Al to mimic the interface present during cold forming processes of Al based alloys. The Al nonamer was disrupted and Al forms chemical bonds with oxygen contained in the O2 exposed Mo2BC(0 4 0) surface. Based on the comparison of here calculated adsorption energy with literature data, Alsbnd Al bonds are shown to be significantly weaker than the Alsbnd O bonds formed across the interface. Hence, Alsbnd Al bond rupture is expected for a mechanically loaded interface. Therefore the adhesion of a residual Al on the native oxide layer is predicted. This is consistent with experimental observations. The data presented here may also be relevant for other oxygen containing surfaces in a contact with Al or Al based alloys for example during forming operations.

ESCA studies of lunar surface chemistry. [Electron Spectroscopic Chemical Analysis

NASA Technical Reports Server (NTRS)

Housley, R. M.; Grant, R. W.

1975-01-01

We have used ESCA to compare the composition of the natural exterior surface in lunar fines samples with that of the interior surface exposed by crushing. Even though the exterior surfaces have been exposed to air a significant amount of Fe in them is reduced. In addition, Ca, Al, and Mg are strongly depleted in exterior surfaces relative to Si, Ti, and Fe. Preferential sputtering by the solar wind is a possible explanation for these changes.

Drug delivery to the ocular posterior segment using lipid emulsion via eye drop administration: effect of emulsion formulations and surface modification.

PubMed

Ying, Lin; Tahara, Kohei; Takeuchi, Hirofumi

2013-09-10

This work explored submicron-sized lipid emulsion as potential carriers for intraocular drug delivery to the posterior segment via eye drops. The effects of physicochemical properties of lipid emulsion on drug delivery were evaluated in vivo using mice. Different formulations of submicron-sized lipid emulsions were prepared using a high pressure homogenization system. Using coumairn-6 as a model drug and fluorescent marker, fluorescence could be observed in the retina after administration of the lipid emulsion. The fluorescence intensity observed after administration of medium chain triglycerides containing the same amount of coumarin-6 was much lower than that observed after administration of lipid emulsions. The inner oil property and phospholipid emulsifier did not affect the drug delivery efficiency to the retina. However, compared with unmodified emulsions, the fluorescence intensity in the retina increased by surface modification using a positive charge inducer and the functional polymers chitosan (CS) and poloxamer 407 (P407). CS-modified lipid emulsions could be electrostatically interacted with the eye surface. By its adhesive property, poloxamer 407, a surface modifier, possibly increased the lipid emulsion retention time on the eye surface. In conclusion, we suggested that surface-modified lipid emulsions could be promising vehicles of hydrophobic drug delivery to the ocular posterior segment. Copyright © 2013. Published by Elsevier B.V.

Technique of semiautomatic surface reconstruction of the visible Korean human data using commercial software.

PubMed

Park, Jin Seo; Shin, Dong Sun; Chung, Min Suk; Hwang, Sung Bae; Chung, Jinoh

2007-11-01

This article describes the technique of semiautomatic surface reconstruction of anatomic structures using widely available commercial software. This technique would enable researchers to promptly and objectively perform surface reconstruction, creating three-dimensional anatomic images without any assistance from computer engineers. To develop the technique, we used data from the Visible Korean Human project, which produced digitalized photographic serial images of an entire cadaver. We selected 114 anatomic structures (skin [1], bones [32], knee joint structures [7], muscles [60], arteries [7], and nerves [7]) from the 976 anatomic images which were generated from the left lower limb of the cadaver. Using Adobe Photoshop, the selected anatomic structures in each serial image were outlined, creating a segmented image. The Photoshop files were then converted into Adobe Illustrator files to prepare isolated segmented images, so that the contours of the structure could be viewed independent of the surrounding anatomy. Using Alias Maya, these isolated segmented images were then stacked to construct a contour image. Gaps between the contour lines were filled with surfaces, and three-dimensional surface reconstruction could be visualized with Rhinoceros. Surface imperfections were then corrected to complete the three-dimensional images in Alias Maya. We believe that the three-dimensional anatomic images created by these methods will have widespread application in both medical education and research. 2007 Wiley-Liss, Inc

Statistical signal processing technique for identification of different infected sites of the diseased lungs.

PubMed

Abbas, Ali

2012-06-01

Accurate Diagnosis of lung disease depends on understanding the sounds emanating from lung and its location. Lung sounds are of significance as they supply precise and important information on the health of the respiratory system. In addition, correct interpretation of breath sounds depends on a systematic approach to auscultation; it also requires the ability to describe the location of abnormal finding in relation to bony structures and anatomic landmark lines. Lungs consist of number of lobes; each lung lobe is further subdivided into smaller segments. These segments are attached to each other. Knowledge of the position of the lung segments is useful and important during the auscultation and diagnosis of the lung diseases. Usually the medical doctors give the location of the infection a segmental position reference. Breath sounds are auscultated over the anterior chest wall surface, the lateral chest wall surfaces, and posterior chest wall surface. Adventitious sounds from different location can be detected. It is common to seek confirmation of the sound detection and its location using invasive and potentially harmful imaging diagnosis techniques like x-rays. To overcome this limitation and for fast, reliable, accurate, and inexpensive diagnose a technique is developed in this research for identifying the location of infection through a computerized auscultation system.

Fabrication and testing of the first 8.4-m off-axis segment for the Giant Magellan Telescope

NASA Astrophysics Data System (ADS)

Martin, H. M.; Allen, R. G.; Burge, J. H.; Kim, D. W.; Kingsley, J. S.; Tuell, M. T.; West, S. C.; Zhao, C.; Zobrist, T.

2010-07-01

The primary mirror of the Giant Magellan Telescope consists of seven 8.4 m segments which are borosilicate honeycomb sandwich mirrors. Fabrication and testing of the off-axis segments is challenging and has led to a number of innovations in manufacturing technology. The polishing system includes an actively stressed lap that follows the shape of the aspheric surface, used for large-scale figuring and smoothing, and a passive "rigid conformal lap" for small-scale figuring and smoothing. Four independent measurement systems support all stages of fabrication and provide redundant measurements of all critical parameters including mirror figure, radius of curvature, off-axis distance and clocking. The first measurement uses a laser tracker to scan the surface, with external references to compensate for rigid body displacements and refractive index variations. The main optical test is a full-aperture interferometric measurement, but it requires an asymmetric null corrector with three elements, including a 3.75 m mirror and a computer-generated hologram, to compensate for the surface's 14 mm departure from the best-fit sphere. Two additional optical tests measure large-scale and small-scale structure, with some overlap. Together these measurements provide high confidence that the segments meet all requirements.

Dual Contrast CT Method Enables Diagnostics of Cartilage Injuries and Degeneration Using a Single CT Image.

PubMed

Saukko, Annina E A; Honkanen, Juuso T J; Xu, Wujun; Väänänen, Sami P; Jurvelin, Jukka S; Lehto, Vesa-Pekka; Töyräs, Juha

2017-12-01

Cartilage injuries may be detected using contrast-enhanced computed tomography (CECT) by observing variations in distribution of anionic contrast agent within cartilage. Currently, clinical CECT enables detection of injuries and related post-traumatic degeneration based on two subsequent CT scans. The first scan allows segmentation of articular surfaces and lesions while the latter scan allows evaluation of tissue properties. Segmentation of articular surfaces from the latter scan is difficult since the contrast agent diffusion diminishes the image contrast at surfaces. We hypothesize that this can be overcome by mixing anionic contrast agent (ioxaglate) with bismuth oxide nanoparticles (BINPs) too large to diffuse into cartilage, inducing a high contrast at the surfaces. Here, a dual contrast method employing this mixture is evaluated by determining the depth-wise X-ray attenuation profiles in intact, enzymatically degraded, and mechanically injured osteochondral samples (n = 3 × 10) using a microCT immediately and at 45 min after immersion in contrast agent. BiNPs were unable to diffuse into cartilage, producing high contrast at articular surfaces. Ioxaglate enabled the detection of enzymatic and mechanical degeneration. In conclusion, the dual contrast method allowed detection of injuries and degeneration simultaneously with accurate cartilage segmentation using a single scan conducted at 45 min after contrast agent administration.

Mapping of the surface rupture induced by the M 7.3 Kumamoto Earthquake along the Eastern segment of Futagawa fault using image correlation techniques

NASA Astrophysics Data System (ADS)

Ekhtari, N.; Glennie, C. L.; Fielding, E. J.; Liang, C.

2016-12-01

Near field surface deformation is vital to understanding the shallow fault physics of earthquakes but near-field deformation measurements are often sparse or not reliable. In this study, we use the Co-seismic Image Correlation (COSI-Corr) technique to map the near-field surface deformation caused by the M 7.3 April 16, 2016 Kumamoto Earthquake, Kyushu, Japan. The surface rupture around the Eastern segment of Futagawa fault is mapped using a pair of panchromatic 1.5 meter resolution SPOT 7 images. These images were acquired on January 16 and April 29, 2016 (3 months before and 13 days after the earthquake respectively) with close to nadir (less than 1.5 degree off nadir) viewing angle. The two images are ortho-rectified using SRTM Digital Elevation Model and further co-registered using tie points far away from the rupture field. Then the COSI-Corr technique is utilized to produce an estimated surface displacement map, and a horizontal displacement vector field is calculated which supplies a seamless estimate of near field displacement measurements along the Eastern segment of the Futagawa fault. The COSI-Corr estimated displacements are then compared to other existing displacement observations from InSAR, GPS and field observations.

Pulmonary Lobe Segmentation with Probabilistic Segmentation of the Fissures and a Groupwise Fissure Prior

PubMed Central

Bragman, Felix J.S.; McClelland, Jamie R.; Jacob, Joseph; Hurst, John R.; Hawkes, David J.

2017-01-01

A fully automated, unsupervised lobe segmentation algorithm is presented based on a probabilistic segmentation of the fissures and the simultaneous construction of a population model of the fissures. A two-class probabilistic segmentation segments the lung into candidate fissure voxels and the surrounding parenchyma. This was combined with anatomical information and a groupwise fissure prior to drive non-parametric surface fitting to obtain the final segmentation. The performance of our fissure segmentation was validated on 30 patients from the COPDGene cohort, achieving a high median F1-score of 0.90 and showed general insensitivity to filter parameters. We evaluated our lobe segmentation algorithm on the LOLA11 dataset, which contains 55 cases at varying levels of pathology. We achieved the highest score of 0.884 of the automated algorithms. Our method was further tested quantitatively and qualitatively on 80 patients from the COPDGene study at varying levels of functional impairment. Accurate segmentation of the lobes is shown at various degrees of fissure incompleteness for 96% of all cases. We also show the utility of including a groupwise prior in segmenting the lobes in regions of grossly incomplete fissures. PMID:28436850

Denaturation of RNA secondary and tertiary structure by urea: simple unfolded state models and free energy parameters account for measured m-values

PubMed Central

Lambert, Dominic; Draper, David E.

2012-01-01

To investigate the mechanism by which urea destabilizes RNA structure, urea-induced unfolding of four different RNA secondary and tertiary structures was quantified in terms of an m-value, the rate at which the free energy of unfolding changes with urea molality. From literature data and our osmometric study of a backbone analog, we derived average interaction potentials (per Å2 of solvent accessible surface) between urea and three kinds of RNA surfaces: phosphate, ribose, and base. Estimates of the increases in solvent accessible surface areas upon RNA denaturation were based on a simple model of unfolded RNA as a combination of helical and single strand segments. These estimates, combined with the three interaction potentials and a term to account for urea interactions with released ions, yield calculated m-values in good agreement with experimental values (200 mm monovalent salt). Agreement was obtained only if single-stranded RNAs were modeled in a highly stacked, A form conformation. The primary driving force for urea induced denaturation is the strong interaction of urea with the large surface areas of bases that become exposed upon denaturation of either RNA secondary or tertiary structure, though urea interactions with backbone and released ions may account for up to a third of the m-value. Urea m-values for all four RNA are salt-dependent, which we attribute to an increased extension (or decreased charge density) of unfolded RNAs with increased urea concentration. The sensitivity of the urea m-value to base surface exposure makes it a potentially useful probe of the conformations of RNA unfolded states. PMID:23088364

Segmentation of knee MRI using structure enhanced local phase filtering

NASA Astrophysics Data System (ADS)

Lim, Mikhiel; Hacihaliloglu, Ilker

2016-03-01

The segmentation of bone surfaces from magnetic resonance imaging (MRI) data has applications in the quanti- tative measurement of knee osteoarthritis, surgery planning for patient specific total knee arthroplasty and its subsequent fabrication of artificial implants. However, due to the problems associated with MRI imaging such as low contrast between bone and surrounding tissues, noise, bias fields, and the partial volume effect, segmentation of bone surfaces continues to be a challenging operation. In this paper, a new framework is presented for the enhancement of knee MRI scans prior to segmentation in order to obtain high contrast bone images. During the first stage, a new contrast enhanced relative total variation (RTV) regularization method is used in order to remove textural noise from the bone structures and surrounding soft tissue interface. This salient bone edge information is further enhanced using a sparse gradient counting method based on L0 gradient minimization, which globally controls how many non-zero gradients are resulted in order to approximate prominent bone structures in a structure-sparsity-management manner. The last stage of the framework involves incorporation of local phase bone boundary information in order to provide an intensity invariant enhancement of contrast between the bone and surrounding soft tissue. The enhanced images are segmented using a fast random walker algorithm. Validation against expert segmentation was performed on 10 clinical knee MRI images, and achieved a mean dice similarity coefficient (DSC) of 0.975.

W. M. Keck Observatory primary mirror segment repair project: overview and status

NASA Astrophysics Data System (ADS)

Meeks, Robert L.; Doyle, Steve; Higginson, Jamie; Hudek, John S.; Irace, William; McBride, Dennis; Pollard, Mike; Tai, Kuochou; Von Boeckmann, Tod; Wold, Leslie; Wold, Truman

2016-07-01

The W. M. Keck Observatory Segment Repair Project is repairing stress-induced fractures near the support points in the primary mirror segments. The cracks are believed to result from deficiencies in the original design and implementation of the adhesive joints connecting the Invar support components to the ZERODUR mirror. Stresses caused by temperature cycling over 20 years of service drove cracks that developed at the glass-metal interfaces. Over the last few years the extent and cause of the cracks have been studied, and new supports have been designed. Repair of the damaged glass required development of specialized tools and procedures for: (1) transport of the segments; (2) pre-repair metrology to establish the initial condition; (3) removal of support hardware assemblies; (4) removal of the original supports; (5) grinding and re-surfacing the damaged glass areas; (6) etching to remove sub-surface damage; (7) bonding new supports; (8) re-installation of support assemblies; and (9) post-repair metrology. Repair of the first segment demonstrated the new tools and processes. On-sky measurements before and after repair verified compliance with the requirements. This paper summarizes the repair process, on-sky results, and transportation system, and also provides an update on the project status and schedule for repairing all 84 mirror segments. Strategies for maintaining quality and ensuring that repairs are done consistently are also presented.

3D statistical shape models incorporating 3D random forest regression voting for robust CT liver segmentation

NASA Astrophysics Data System (ADS)

Norajitra, Tobias; Meinzer, Hans-Peter; Maier-Hein, Klaus H.

2015-03-01

During image segmentation, 3D Statistical Shape Models (SSM) usually conduct a limited search for target landmarks within one-dimensional search profiles perpendicular to the model surface. In addition, landmark appearance is modeled only locally based on linear profiles and weak learners, altogether leading to segmentation errors from landmark ambiguities and limited search coverage. We present a new method for 3D SSM segmentation based on 3D Random Forest Regression Voting. For each surface landmark, a Random Regression Forest is trained that learns a 3D spatial displacement function between the according reference landmark and a set of surrounding sample points, based on an infinite set of non-local randomized 3D Haar-like features. Landmark search is then conducted omni-directionally within 3D search spaces, where voxelwise forest predictions on landmark position contribute to a common voting map which reflects the overall position estimate. Segmentation experiments were conducted on a set of 45 CT volumes of the human liver, of which 40 images were randomly chosen for training and 5 for testing. Without parameter optimization, using a simple candidate selection and a single resolution approach, excellent results were achieved, while faster convergence and better concavity segmentation were observed, altogether underlining the potential of our approach in terms of increased robustness from distinct landmark detection and from better search coverage.

An improved segmentation method for defects inspection on steel roller surface

NASA Astrophysics Data System (ADS)

Xu, Jirui; Li, Xuekun; Cao, Yuzhong; Shi, Depeng; Yang, Jun; Jiang, Sheng; Rong, Yiming

2018-05-01

In the field of metal rolling, the quality of the steel roller's surface is significant for the final rolling products, e.g. metal sheets or foils. Besides the dimensional accuracy and surface roughness, the optical uniformity of the roller surface is also required for high quality rolling application. The typical optical defects of rollers after finish grinding include speckles, chatter marks, feed traces, and combination of all above. Unlike surface roughness, the optical defects can hardly be characterized by the topography or scanning electrical microscope measurement. Only the inspection by bared eyes of experienced engineers appears to be the effective manner for surface optical defects examination for large steel rollers. In this paper, an on-site machine vision system is designed to add on to the roller grinding machine to capture the surface image, and then an improved optical defects segmentation algorithm is developed based on the active contour model. Finally, experiments are carried out to verify the efficacy of the improved model.

Reconstructing liver shape and position from MR image slices using an active shape model

NASA Astrophysics Data System (ADS)

Fenchel, Matthias; Thesen, Stefan; Schilling, Andreas

2008-03-01

We present an algorithm for fully automatic reconstruction of 3D position, orientation and shape of the human liver from a sparsely covering set of n 2D MR slice images. Reconstructing the shape of an organ from slice images can be used for scan planning, for surgical planning or other purposes where 3D anatomical knowledge has to be inferred from sparse slices. The algorithm is based on adapting an active shape model of the liver surface to a given set of slice images. The active shape model is created from a training set of liver segmentations from a group of volunteers. The training set is set up with semi-manual segmentations of T1-weighted volumetric MR images. Searching for the optimal shape model that best fits to the image data is done by maximizing a similarity measure based on local appearance at the surface. Two different algorithms for the active shape model search are proposed and compared: both algorithms seek to maximize the a-posteriori probability of the grey level appearance around the surface while constraining the surface to the space of valid shapes. The first algorithm works by using grey value profile statistics in normal direction. The second algorithm uses average and variance images to calculate the local surface appearance on the fly. Both algorithms are validated by fitting the active shape model to abdominal 2D slice images and comparing the shapes, which have been reconstructed, to the manual segmentations and to the results of active shape model searches from 3D image data. The results turn out to be promising and competitive to active shape model segmentations from 3D data.

The intracranial facial nerve as seen through different surgical windows: an extensive anatomosurgical study.

PubMed

Bernardo, Antonio; Evins, Alexander I; Visca, Anna; Stieg, Phillip E

2013-06-01

The facial nerve has a short intracranial course but crosses critical and frequently accessed surgical structures during cranial base surgery. When performing approaches to complex intracranial regions, it is essential to understand the nerve's conventional and topographic anatomy from different surgical perspectives as well as its relationship with surrounding structures. To describe the entire intracranial course of the facial nerve as observed via different neurosurgical approaches and to provide an analytical evaluation of the degree of nerve exposure achieved with each approach. Anterior petrosectomies (middle fossa, extended middle fossa), posterior petrosectomies (translabyrinthine, retrolabyrinthine, transcochlear), a retrosigmoid, a far lateral, and anterior transfacial (extended maxillectomy, mandibular swing) approaches were performed on 10 adult cadaveric heads (20 sides). The degree of facial nerve exposure achieved per segment for each approach was assessed and graded independently by 3 surgeons. The anterior petrosal approaches offered good visualization of the nerve in the cerebellopontine angle and intracanalicular portion superiorly, whereas the posterior petrosectomies provided more direct visualization without the need for cerebellar retraction. The far lateral approach exposed part of the posterior and the entire inferior quadrants, whereas the retrosigmoid approach exposed parts of the superior and inferior quadrants and the entire posterior quadrant. Anterior and anteroinferior exposure of the facial nerve was achieved via the transfacial approaches. The surgical route used must rely on the size, nature, and general location of the lesion, as well as on the capability of the particular approach to better expose the appropriate segment of the facial nerve.

Human erythrocyte band 3 functions as a receptor for the sialic acid-independent invasion of Plasmodium falciparum. Role of the RhopH3-MSP1 complex.

PubMed

Baldwin, Michael; Yamodo, Innocent; Ranjan, Ravi; Li, Xuerong; Mines, Gregory; Marinkovic, Marina; Hanada, Toshihiko; Oh, Steven S; Chishti, Athar H

2014-12-01

Plasmodium falciparum takes advantage of two broadly defined alternate invasion pathways when infecting human erythrocytes: one that depends on and the other that is independent of host sialic acid residues on the erythrocyte surface. Within the sialic acid-dependent (SAD) and sialic acid-independent (SAID) invasion pathways, several alternate host receptors are used by P. falciparum based on its particular invasion phenotype. Earlier, we reported that two putative extracellular regions of human erythrocyte band 3 termed 5C and 6A function as host invasion receptor segments binding parasite proteins MSP1 and MSP9 via a SAID mechanism. In this study, we developed two mono-specific anti-peptide chicken IgY antibodies to demonstrate that the 5C and 6A regions of band 3 are exposed on the surface of human erythrocytes. These antibodies inhibited erythrocyte invasion by the P. falciparum 3D7 and 7G8 strains (SAID invasion phenotype), and the blocking effect was enhanced in sialic acid-depleted erythrocytes. In contrast, the IgY antibodies had only a marginal inhibitory effect on FCR3 and Dd2 strains (SAD invasion phenotype). A direct biochemical interaction between erythrocyte band 3 epitopes and parasite RhopH3, identified by the yeast two-hybrid screen, was established. RhopH3 formed a complex with MSP119 and the 5ABC region of band 3, and a recombinant segment of RhopH3 inhibited parasite invasion in human erythrocytes. Together, these findings provide evidence that erythrocyte band 3 functions as a major host invasion receptor in the SAID invasion pathway by assembling a multi-protein complex composed of parasite ligands RhopH3 and MSP1. Copyright © 2014 Elsevier B.V. All rights reserved.

A model for radial dike emplacement in composite cones based on observations from Summer Coon volcano, Colorado, USA

USGS Publications Warehouse

Poland, Michael P.; Moats, W.P.; Fink, J.H.

2008-01-01

We mapped the geometry of 13 silicic dikes at Summer Coon, an eroded Oligocene stratovolcano in southern Colorado, to investigate various characteristics of radial dike emplacement in composite volcanoes. Exposed dikes are up to about 7 km in length and have numerous offset segments along their upper peripheries. Surprisingly, most dikes at Summer Coon increase in thickness with distance from the center of the volcano. Magma pressure in a dike is expected to lessen away from the pressurized source region, which would encourage a blade-like dike to decrease in thickness with distance from the center of the volcano. We attribute the observed thickness pattern as evidence of a driving pressure gradient, which is caused by decreasing host rock shear modulus and horizontal stress, both due to decreasing emplacement depths beneath the sloping flanks of the volcano. Based on data from Summer Coon, we propose that radial dikes originate at depth below the summit of a host volcano and follow steeply inclined paths towards the surface. Near the interface between volcanic cone and basement, which may represent a neutral buoyancy surface or stress barrier, magma is transported subhorizontally and radially away from the center of the volcano in blade-like dikes. The dikes thicken with increasing radial distance, and offset segments and fingers form along the upper peripheries of the intrusions. Eruptions may occur anywhere along the length of the dikes, but the erupted volume will generally be greater for dike-fed eruptions far from the center of the host volcano owing to the increase in driving pressure with distance from the source. Observed eruptive volumes, vent locations, and vent-area intrusions from inferred post-glacial dike-fed eruptions at Mount Adams, Washington, USA, support the proposed model. Hazards associated with radial dike emplacement are therefore greater for longer dikes that propagate to the outer flanks of a volcano. ?? Springer-Verlag 2007.

40 CFR 761.257 - Determining the regulatory status of sampled pipe.

Code of Federal Regulations, 2010 CFR

2010-07-01

... COMMERCE, AND USE PROHIBITIONS Determining a PCB Concentration for Purposes of Abandonment or Disposal of Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe... disposal of a pipe segment that has been sampled, the sample results for that segment determines its PCB...

Status of mirror segment production for the Giant Magellan Telescope

NASA Astrophysics Data System (ADS)

Martin, H. M.; Burge, J. H.; Davis, J. M.; Kim, D. W.; Kingsley, J. S.; Law, K.; Loeff, A.; Lutz, R. D.; Merrill, C.; Strittmatter, P. A.; Tuell, M. T.; Weinberger, S. N.; West, S. C.

2016-07-01

The Richard F. Caris Mirror Lab at the University of Arizona is responsible for production of the eight 8.4 m segments for the primary mirror of the Giant Magellan Telescope, including one spare off-axis segment. We report on the successful casting of Segment 4, the center segment. Prior to generating the optical surface of Segment 2, we carried out a major upgrade of our 8.4 m Large Optical Generator. The upgrade includes new hardware and software to improve accuracy, safety, reliability and ease of use. We are currently carrying out an upgrade of our 8.4 m polishing machine that includes improved orbital polishing capabilities. We added and modified several components of the optical tests during the manufacture of Segment 1, and we have continued to improve the systems in preparation for Segments 2-8. We completed two projects that were prior commitments before GMT Segment 2: casting and polishing the combined primary and tertiary mirrors for the LSST, and casting and generating a 6.5 m mirror for the Tokyo Atacama Observatory.

Scanning electron microscopic and X-ray micro analysis on tooth enamel exposed to alkaline agents.

PubMed

Taubee, Fabian; Steiniger, Frank; Nietzsche, Sandor; Norén, Jörgen G

2010-01-01

The background of this study comprises two clinical cases, where patients exposed to aerosols of an alkaline and surface active cleaning agent developed loss of enamel substance on their teeth, further resulting in loss of teeth and partially destroyed soft tissues. The alkaline cleaning agent consisted of potassium hydroxide and various surfactants. The purpose of this study was to investigate possible changes in morphology and composition in human teeth enamel exposed to alkaline solutions, by means of X-ray micro analysis (XRMA), FTIR-spectroscopic analyses and scanning electron microscopy (SEM). Extracted premolars, exposed to potassium hydroxide solutions and alkaline cleaning solution,were analyzed by means of XRMA and SEM. Enamel powder, exposed to cleaning solution, was analyzed by means of FTIR. The SEM analysis revealed an increased porosity of the enamel surface and partially loss of enamel substance after exposure to alkaline solutions. The XRMA analyses revealed a decrease in carbon concentration while phosphorous and calcium showed no marked changes. The FTIR analyses showed no significant changes in peak heights or peak positions for phosphate, carbonate or hydroxide. It was concluded that human teeth enamel exposed to alkaline solutions showed loss of organic substance, marked pores in enamel surface and loss of substance in the enamel surface.

Hierarchical decomposition of burn body diagram based on cutaneous functional units and its utility.

PubMed

Richard, Reg; Jones, John A; Parshley, Philip

2015-01-01

A burn body diagram (BBD) is a common feature used in the delivery of burn care for estimating the TBSA burn as well as calculating fluid resuscitation and nutritional requirements, wound healing, and rehabilitation intervention. However, little change has occurred for over seven decades in the configuration of the BBD. The purpose of this project was to develop a computerized model using hierarchical decomposition (HD) to more precisely determine the percentage burn within a BBD based on cutaneous functional units (CFUs). HD is a process by which a system is degraded into smaller parts that are more precise in their use. CFUs were previously identified fields of the skin involved in the range of motion. A standard Lund/Browder (LB) BBD template was used as the starting point to apply the CFU segments. LB body divisions were parceled down into smaller body area divisions through a HD process based on the CFU concept. A numerical pattern schema was used to label the various segments in a cephalo/caudal, anterior/posterior, medial/lateral manner. Hand/fingers were divided based on anatomical landmarks and known cutaneokinematic function. The face was considered using aesthetic units. Computer code was written to apply the numeric hierarchical schema to CFUs and applied within the context of the surface area graphic evaluation BBD program. Each segmented CFU was coded to express 100% of itself. The CFU/HD method refined the standard LB diagram from 13 body segments and 33 subdivisions into 182 isolated CFUs. Associated CFUs were reconstituted into 219 various surface area combinations totaling 401 possible surface segments. The CFU/HD schema of the body surface mapping is applicable to measuring and calculating percent wound healing in a more precise manner. It eliminates subjective assessment of the percentage wound healing and the need for additional devices such as planimetry. The development of CFU/HD body mapping schema has rendered a technologically advanced system to depict body burns. The process has led to a more precise estimation of the segmented body areas while preserving the overall TBSA information. Clinical application to date has demonstrated its worthwhile utility.

Structure of the San Andreas Fault Zone in the Salton Trough Region of Southern California: A Comparison with San Andreas Fault Structure in the Loma Prieta Area of Central California

NASA Astrophysics Data System (ADS)

Fuis, G. S.; Catchings, R.; Scheirer, D. S.; Goldman, M.; Zhang, E.; Bauer, K.

2016-12-01

The San Andreas fault (SAF) in the northern Salton Trough, or Coachella Valley, in southern California, appears non-vertical and non-planar. In cross section, it consists of a steeply dipping segment (75 deg dip NE) from the surface to 6- to 9-km depth, and a moderately dipping segment below 6- to 9-km depth (50-55 deg dip NE). It also appears to branch upward into a flower-like structure beginning below about 10-km depth. Images of the SAF zone in the Coachella Valley have been obtained from analysis of steep reflections, earthquakes, modeling of potential-field data, and P-wave tomography. Review of seismological and geodetic research on the 1989 M 6.9 Loma Prieta earthquake, in central California (e.g., U.S. Geological Survey Professional Paper 1550), shows several features of SAF zone structure similar to those seen in the northern Salton Trough. Aftershocks in the Loma Prieta epicentral area form two chief clusters, a tabular zone extending from 18- to 9-km depth and a complex cluster above 5-km depth. The deeper cluster has been interpreted to surround the chief rupture plane, which dips 65-70 deg SW. When double-difference earthquake locations are plotted, the shallower cluster contains tabular subclusters that appear to connect the main rupture with the surface traces of the Sargent and Berrocal faults. In addition, a diffuse cluster may surround a steep to vertical fault connecting the main rupture to the surface trace of the SAF. These interpreted fault connections from the main rupture to surface fault traces appear to define a flower-like structure, not unlike that seen above the moderately dipping segment of the SAF in the Coachella Valley. But importantly, the SAF, interpreted here to include the main rupture plane, appears segmented, as in the Coachella Valley, with a moderately dipping segment below 9-km depth and a steep to vertical segment above that depth. We hope to clarify fault-zone structure in the Loma Prieta area by reanalyzing active-source data collected after the earthquake for steep reflections.

Thin film strain transducer. [suitable for in-flight measurement of scientific balloon strain

NASA Technical Reports Server (NTRS)

Rand, J. L. (Inventor)

1985-01-01

A strain transducer system and process for making same is disclosed wherein a beryllium-copper ring having four strain gages disposed thereon is electrically connected in Wheatstone bridge fashion to output instrumentation. Tabs are bonded to a balloon or like surface with strain on the surface causing bending of the ring and providing an electrical signal through the gages proportional to the surface strain. A figure is provided which illustrates a pattern of a one-half ring segment as placed on a sheet of beryllium-copper for chem-mill etch formation, prior to bending and welding of a pair of the segments to form a ring structure.

Pipe gripper

DOEpatents

Moyers, S.M.

1975-12-16

A device for gripping the exterior surface of a pipe or rod is described which has a plurality of wedges, each having a concave face which engages the outer surface of the pipe and each having a smooth face opposing the concave face. The wedges are seated on and their grooved concave faces are maintained in circular alignment by tapered axial segments of an opening extending through a wedge-seating member. The wedges are allowed to slide across the tapered axial segments so that such a sliding movement acts to vary the diameter of the circular alignment.

Selectively-etched nanochannel electrophoretic and electrochemical devices

DOEpatents

Surh, Michael P.; Wilson, William D.; Barbee, Jr., Troy W.; Lane, Stephen M.

2004-11-16

Nanochannel electrophoretic and electrochemical devices having selectively-etched nanolaminates located in the fluid transport channel. The normally flat surfaces of the nanolaminate having exposed conductive (metal) stripes are selectively-etched to form trenches and baffles. The modifications of the prior utilized flat exposed surfaces increase the amount of exposed metal to facilitate electrochemical redox reaction or control the exposure of the metal surfaces to analytes of large size. These etched areas variously increase the sensitivity of electrochemical detection devices to low concentrations of analyte, improve the plug flow characteristic of the channel, and allow additional discrimination of the colloidal particles during cyclic voltammetry.

Selectively-etched nanochannel electrophoretic and electrochemical devices

DOEpatents

Surh, Michael P [Livermore, CA; Wilson, William D [Pleasanton, CA; Barbee, Jr., Troy W.; Lane, Stephen M [Oakland, CA

2006-06-27

Nanochannel electrophoretic and electrochemical devices having selectively-etched nanolaminates located in the fluid transport channel. The normally flat surfaces of the nanolaminate having exposed conductive (metal) stripes are selectively-etched to form trenches and baffles. The modifications of the prior utilized flat exposed surfaces increase the amount of exposed metal to facilitate electrochemical redox reaction or control the exposure of the metal surfaces to analytes of large size. These etched areas variously increase the sensitivity of electrochemical detection devices to low concentrations of analyte, improve the plug flow characteristic of the channel, and allow additional discrimination of the colloidal particles during cyclic voltammetry.

Surface-exposed and antigenically conserved determinants of outer membrane proteins of Branhamella catarrhalis.

PubMed Central

Murphy, T F; Bartos, L C

1989-01-01

The outer membrane proteins (OMPs) of Branhamella catarrhalis were studied in an effort to identify surface-exposed determinants that are conserved among strains of the bacterium. Aliquots of polyclonal antiserum were absorbed individually by strains of B. catarrhalis. The absorbed antisera were tested in comparison with unabsorbed antiserum in an immunoblot assay against OMPs of the homologous strain. The absence of a band recognized by antibodies in the absorbed antiserum compared with the unabsorbed antiserum indicated that surface-exposed determinants of the absorbing strain cross-reacted with determinants on the homologous strain. Two antisera were absorbed individually by 20 strains of B. catarrhalis, and the absorbed sera were studied in this way in immunoblot assays. OMP E (molecular weight, ca. 56,000) expresses surface-exposed determinants that are shared among 17 of the 20 strains studied. Antibodies to OMP G (molecular weight, 28,000) were absorbed from both antisera by 14 of the 20 strains. These studies demonstrate that OMP E and OMP G express determinants that are exposed on the surface of the intact bacterium. Furthermore, these determinants are antigenically conserved among a majority of strains of B. catarrhalis. On the basis of these observations, OMPs E and G should be considered when bacterial antigens are evaluated as potential vaccine candidates. Images PMID:2476393

Effect of Blood Contamination on Marginal Adaptation and Surface Microstructure of Mineral Trioxide Aggregate: A SEM Study.

PubMed

Salem Milani, Amin; Rahimi, Saeed; Froughreyhani, Mohammad; Vahid Pakdel, Mahdi

2013-01-01

In various clinical situations, mineral trioxide aggregate (MTA) may come into direct contact or even be mixed with blood. The aim of the present study was to evaluate the effect of exposure to blood on marginal adaptation and surface microstructure of MTA. Thirty extracted human single-rooted teeth were used. Standard root canal treatment was carried out. Root-ends were resected, and retrocavities were prepared. The teeth were randomly divided into two groups (n = 15): in group 1, the internal surface of the cavities was coated with fresh blood. Then, the cavities were filled with MTA. The roots were immersed in molds containing fresh blood. In group 2, the aforementioned procedures were performed except that synthetic tissue fluid (STF) was used instead of blood. To assess the marginal adaptation, "gap perimeter" and "maximum gap width" were measured under scanning electron microscope. The surface microstructure was also examined. Independent samples t-test and Mann-Whitney U test were used to analyze the data. Maximum gap width and gap perimeter in the blood-exposed group were significantly larger than those in the STF-exposed group (p < 0.01). In the blood-exposed group, the crystals tended to be more rounded and less angular compared with the STF-exposed group, and there was a general lack of needle-like crystals. Exposure to blood during setting has a negative effect on marginal adaptation of MTA, and blood-exposed MTA has a different surface microstructure compared to STF-exposed MTA.

Impervious surface mapping with Quickbird imagery

PubMed Central

Lu, Dengsheng; Hetrick, Scott; Moran, Emilio

2010-01-01

This research selects two study areas with different urban developments, sizes, and spatial patterns to explore the suitable methods for mapping impervious surface distribution using Quickbird imagery. The selected methods include per-pixel based supervised classification, segmentation-based classification, and a hybrid method. A comparative analysis of the results indicates that per-pixel based supervised classification produces a large number of “salt-and-pepper” pixels, and segmentation based methods can significantly reduce this problem. However, neither method can effectively solve the spectral confusion of impervious surfaces with water/wetland and bare soils and the impacts of shadows. In order to accurately map impervious surface distribution from Quickbird images, manual editing is necessary and may be the only way to extract impervious surfaces from the confused land covers and the shadow problem. This research indicates that the hybrid method consisting of thresholding techniques, unsupervised classification and limited manual editing provides the best performance. PMID:21643434

The use of an ion-beam source to alter the surface morphology of biological implant materials

NASA Technical Reports Server (NTRS)

Weigand, A. J.

1978-01-01

An electron-bombardment ion-thruster was used as a neutralized-ion-beam sputtering source to texture the surfaces of biological implant materials. The materials investigated included 316 stainless steel; titanium-6% aluminum, 4% vanadium; cobalt-20% chromium, 15% tungsten; cobalt-35% nickel, 20% chromium, 10% molybdenum; polytetrafluoroethylene; polyoxymethylene; silicone and polyurethane copolymer; 32%-carbon-impregnated polyolefin; segmented polyurethane; silicone rubber; and alumina. Scanning electron microscopy was used to determine surface morphology changes of all materials after ion-texturing. Electron spectroscopy for chemical analysis was used to determine the effects of ion-texturing on the surface chemical composition of some polymers. Liquid contact angle data were obtained for ion-textured and untextured polymer samples. Results of tensile and fatigue tests of ion-textured metal alloys are presented. Preliminary data of tissue response to ion-textured surfaces of some metals, polytetrafluoroethylene, alumina, and segmented polyurethane have been obtained.

Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

PubMed Central

Krey, Thomas; Meola, Annalisa; Keck, Zhen-yong; Damier-Piolle, Laurence; Foung, Steven K. H.; Rey, Felix A.

2013-01-01

The high mutation rate of hepatitis C virus allows it to rapidly evade the humoral immune response. However, certain epitopes in the envelope glycoproteins cannot vary without compromising virus viability. Antibodies targeting these epitopes are resistant to viral escape from neutralization and understanding their binding-mode is important for vaccine design. Human monoclonal antibodies HC84-1 and HC84-27 target conformational epitopes overlapping the CD81 receptor-binding site, formed by segments aa434–446 and aa610–619 within the major HCV glycoprotein E2. No neutralization escape was yet observed for these antibodies. We report here the crystal structures of their Fab fragments in complex with a synthetic peptide comprising aa434–446. The structures show that the peptide adopts an α-helical conformation with the main contact residues F442 and Y443 forming a hydrophobic protrusion. The peptide retained its conformation in both complexes, independently of crystal packing, indicating that it reflects a surface feature of the folded glycoprotein that is exposed similarly on the virion. The same residues of E2 are also involved in interaction with CD81, suggesting that the cellular receptor binds the same surface feature and potential escape mutants critically compromise receptor binding. In summary, our results identify a critical structural motif at the E2 surface, which is essential for virus propagation and therefore represents an ideal candidate for structure-based immunogen design for vaccine development. PMID:23696737

Current Status of the Quality of 4H-SiC Substrates and Epilayers for Power Device Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dudley, M.; Wang, H.; Guo, Jianqiu

ABSTRACT Interfacial dislocations (IDs) and half-loop arrays (HLAs) present in the epilayers of 4H-SiC crystal are known to have a deleterious effect on device performance. Synchrotron X-ray Topography studies carried out on n-type 4H-SiC offcut wafers before and after epitaxial growth show that in many cases BPD segments in the substrate are responsible for creating IDs and HLAs during CVD growth. This paper reviews the behaviors of BPDs in the substrate during the epitaxial growth in different cases: (1) screw-oriented BPD segments intersecting the surface replicate directly through the interface during the epitaxial growth and take part in stress relaxationmore » process by creating IDs and HLAs (Matthews-Blakeslee model [1] ); (2) non-screw oriented BPD half loop intersecting the surface glides towards and replicates through the interface, while the intersection points convert to threading edge dislocations (TEDs) and pin the half loop, leaving straight screw segments in the epilayer and then create IDs and HLAs; (3) edge oriented short BPD segments well below the surface get dragged towards the interface during epitaxial growth, leaving two long screw segments in their wake, some of which replicate through the interface and create IDs and HLAs. The driving force for the BPDs to glide toward the interface is thermal stress and driving force for the relaxation process to occur is the lattice parameter difference at growth temperature which results from the doping concentration difference between the substrate and epilayer.« less

Fusion of cone-beam CT and 3D photographic images for soft tissue simulation in maxillofacial surgery

NASA Astrophysics Data System (ADS)

Chung, Soyoung; Kim, Joojin; Hong, Helen

2016-03-01

During maxillofacial surgery, prediction of the facial outcome after surgery is main concern for both surgeons and patients. However, registration of the facial CBCT images and 3D photographic images has some difficulties that regions around the eyes and mouth are affected by facial expressions or the registration speed is low due to their dense clouds of points on surfaces. Therefore, we propose a framework for the fusion of facial CBCT images and 3D photos with skin segmentation and two-stage surface registration. Our method is composed of three major steps. First, to obtain a CBCT skin surface for the registration with 3D photographic surface, skin is automatically segmented from CBCT images and the skin surface is generated by surface modeling. Second, to roughly align the scale and the orientation of the CBCT skin surface and 3D photographic surface, point-based registration with four corresponding landmarks which are located around the mouth is performed. Finally, to merge the CBCT skin surface and 3D photographic surface, Gaussian-weight-based surface registration is performed within narrow-band of 3D photographic surface.

[Ocular surface system integrity].

PubMed

Safonova, T N; Pateyuk, L S

2015-01-01

The interplay of different structures belonging to either the anterior segment of the eye or its accessory visual apparatus, which all share common embryological, anatomical, functional, and physiological features, is discussed. Explanation of such terms, as ocular surface, lacrimal functional unit, and ocular surface system, is provided.

Weathering pits as indicators of the relative age of granite surfaces in the Cairngorm mountains, Scotland

USGS Publications Warehouse

Hall, A.M.; Phillips, W.M.

2006-01-01

Weathering pits 1-140 cm deep occur on granite surfaces in the Cairngorms associated with a range of landforms, including tors, glacially exposed slabs, large erratics and blockfields. Pit depth is positively correlated with cosmogenic exposure age, and both measures show consistent relationships on individual rock landforms. Rates of pit deepening are non-linear and a best fit is provided by the sigmoidal function D = b1+ exp(b2+b3/t). The deepest pits occur on unmodified tor summits, where 10 Be exposure ages indicate that surfaces have been exposed to weathering for a minimum of 52-297 ka. Glacially exposed surfaces with pits 10-46 cm deep have given 10 Be exposure durations of 21-79 ka, indicating exposure by glacial erosion before the last glacial cycle. The combination of cosmogenic exposure ages with weathering pit depths greatly extends the area over which inferences can be made regarding the ages of granite surfaces in the Cairngorms. Well-developed weathering pits on glacially exposed surfaces in other granite areas are potential indicators of glacial erosion before the Last Glacial Maximum. ?? Swedish Society for Anthropology and Geography.

Hypersonic aerospace vehicle leading edge cooling using heat pipe, transpiration and film cooling techniques

NASA Astrophysics Data System (ADS)

Modlin, James Michael

An investigation was conducted to study the feasibility of cooling hypersonic vehicle leading edge structures exposed to severe aerodynamic surface heat fluxes using a combination of liquid metal heat pipes and surface mass transfer cooling techniques. A generalized, transient, finite difference based hypersonic leading edge cooling model was developed that incorporated these effects and was demonstrated on an assumed aerospace plane-type wing leading edge section and a SCRAMJET engine inlet leading edge section. The hypersonic leading edge cooling model was developed using an existing, experimentally verified heat pipe model. Two applications of the hypersonic leading edge cooling model were examined. An assumed aerospace plane-type wing leading edge section exposed to a severe laminar, hypersonic aerodynamic surface heat flux was studied. A second application of the hypersonic leading edge cooling model was conducted on an assumed one-quarter inch nose diameter SCRAMJET engine inlet leading edge section exposed to both a transient laminar, hypersonic aerodynamic surface heat flux and a type 4 shock interference surface heat flux. The investigation led to the conclusion that cooling leading edge structures exposed to severe hypersonic flight environments using a combination of liquid metal heat pipe, surface transpiration, and film cooling methods appeared feasible.

Fracture behaviour of the 14Cr ODS steel exposed to helium and liquid lead

NASA Astrophysics Data System (ADS)

Hojna, Anna; Di Gabriele, Fosca; Hadraba, Hynek; Husak, Roman; Kubena, Ivo; Rozumova, Lucia; Bublikova, Petra; Kalivodova, Jana; Matejicek, Jiri

2017-07-01

This work describes the fracture behaviour of the 14Cr ODS steel produced by mechanical alloying process, after high temperature exposures. Small specimens were exposed to helium gas in a furnace at 720 °C for 500 h. Another set of specimens was exposed to flowing liquid lead in the COLONRI II loop at 650 °C for 1000 h. All specimens were tested for the impact and tensile behaviour. The impact test results are compared to other sets of specimens in the as received state and after isothermal annealing at 650 °C for 1000 h. The impact curves of the exposed materials showed positive shifts on the transition temperature. While the upper shelf value did not change in the Pb exposed ODS steel, it significantly increased in the He exposed one. The differences are discussed in terms of surface and subsurface microscopy observation. The embrittlement can be explained as the effect of a slight change in the grain boundary and size distribution combined with the depletion of sub-surface region from alloying elements forming oxide scale on the surface.

Exposure to fine particulate, black carbon, and particle number concentration in transportation microenvironments

NASA Astrophysics Data System (ADS)

Morales Betancourt, R.; Galvis, B.; Balachandran, S.; Ramos-Bonilla, J. P.; Sarmiento, O. L.; Gallo-Murcia, S. M.; Contreras, Y.

2017-05-01

This research determined intake dose of fine particulate matter (PM2.5), equivalent black carbon (eBC), and number of sub-micron particles (Np) for commuters in Bogotá, Colombia. Doses were estimated through measurements of exposure concentration, a surrogate of physical activity, as well as travel times and speeds. Impacts of travel mode, traffic load, and street configuration on dose and exposure were explored. Three road segments were selected because of their different traffic loads and composition, and dissimilar street configuration. The transport modes considered include active modes (walking and cycling) and motorized modes (bus, car, taxi, and motorcycle). Measurements were performed simultaneously in the available modes at each road segment. High average eBC concentrations were observed throughout the campaign, ranging from 20 to 120 μgm-3 . Commuters in motorized modes experienced significantly higher exposure concentrations than pedestrians and bicyclists. The highest average concentrations of PM2.5, eBC , and Np were measured inside the city's Bus Rapid Transit (BRT) system vehicles. Pedestrians and bicycle users in an open street configuration were exposed to the lowest average concentrations of PM2.5 and eBC , six times lower than those experienced by commuters using the BRT in the same street segment. Pedestrians experienced the highest particulate matter intake dose in the road segments studied, despite being exposed to lower concentrations than commuters in motorized modes. Average potential dose of PM2.5 and eBC per unit length traveled were nearly three times higher for pedestrians in a street canyon configuration compared to commuters in public transport. Slower travel speed and elevated inhalation rates dominate PM dose for pedestrians. The presence of dedicated bike lanes on sidewalks has a significant impact on reducing the exposure concentration for bicyclists compared to those riding in mixed traffic lanes. This study proposes a simple method to perform loading effect correction for measurements of black carbon using multiple portable aethalometers.

Topography of the Dictyostelium discoideum plasma membrane: analysis of membrane asymmetry and intermolecular disulfide bonds.

PubMed

Shiozawa, J A; Jelenska, M M; Jacobson, B S

1987-07-28

Through the application of a unique method for isolating plasma membranes, it was possible to specifically iodinate cytoplasm-exposed plasma membrane proteins in vegetative cells of the cellular slime mold Dictyostelium discoideum. The original procedure [Chaney, L. K., & Jacobson, B. S. (1983) J. Biol. Chem. 258, 10062] which involved coating cells with colloidal silica has been modified to yield a more pure preparation. The presence of the continuous and dense silica pellicle on the outside surface of the isolated plasma membrane permitted the specific labeling of cytoplasm-exposed membrane proteins. Lactoperoxidase-catalyzed iodination was employed to label cell-surface and cytoplasm-exposed membrane proteins. The isolated and radioiodinated membranes were then compared and analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The cell-surface and cytoplasmic face labeling patterns were distinct. A total of 65 proteins were found to be accessible to at least one surface of the membrane. Sixteen intermolecular disulfide bond complexes were observed in the plasma membrane of Dictyostelium; most of these complexes involved glycoproteins and, hence, were exposed to the cell surface.

OCT image segmentation of the prostate nerves

NASA Astrophysics Data System (ADS)

Chitchian, Shahab; Weldon, Thomas P.; Fried, Nathaniel M.

2009-08-01

The cavernous nerves course along the surface of the prostate and are responsible for erectile function. Improvements in identification, imaging, and visualization of the cavernous nerves during prostate cancer surgery may improve nerve preservation and postoperative sexual potency. In this study, 2-D OCT images of the rat prostate were segmented to differentiate the cavernous nerves from the prostate gland. Three image features were employed: Gabor filter, Daubechies wavelet, and Laws filter. The features were segmented using a nearestneighbor classifier. N-ary morphological post-processing was used to remove small voids. The cavernous nerves were differentiated from the prostate gland with a segmentation error rate of only 0.058 +/- 0.019.

Emerging Nigerian Muslim Fear over the Implementation of Child's Rights Act

ERIC Educational Resources Information Center

Hassan, Abubakar Kawu; Aboki, Shehu Abdur-Rahman

2013-01-01

This paper examines the Nigerian Muslims' apprehension on the implementation of the child's Rights Act. This is due to the fact that Islam being the religion of the significant segment of Nigerian population has exposed them to the rights of children other than the child Rights Act. Such rights as provided by Islam include right to proper…

49 CFR 571.117 - Standard No. 117; Retreaded pneumatic tires.

Code of Federal Regulations, 2013 CFR

2013-10-01

... more segments of the same ply overlap, or cord fabric that is part of the belt material, may be exposed... manufactured with a casing— (a) From which a belt or ply, or part thereof, is removed during processing; or (b) On which a belt or ply, or part thereof, is added or replaced during processing. S5.2.3Each retreaded...

49 CFR 571.117 - Standard No. 117; Retreaded pneumatic tires.

Code of Federal Regulations, 2012 CFR

2012-10-01

... more segments of the same ply overlap, or cord fabric that is part of the belt material, may be exposed... manufactured with a casing— (a) From which a belt or ply, or part thereof, is removed during processing; or (b) On which a belt or ply, or part thereof, is added or replaced during processing. S5.2.3Each retreaded...

49 CFR 571.117 - Standard No. 117; Retreaded pneumatic tires.

Code of Federal Regulations, 2011 CFR

2011-10-01

... more segments of the same ply overlap, or cord fabric that is part of the belt material, may be exposed... manufactured with a casing— (a) From which a belt or ply, or part thereof, is removed during processing; or (b) On which a belt or ply, or part thereof, is added or replaced during processing. S5.2.3Each retreaded...

49 CFR 571.117 - Standard No. 117; Retreaded pneumatic tires.

Code of Federal Regulations, 2014 CFR

2014-10-01

... more segments of the same ply overlap, or cord fabric that is part of the belt material, may be exposed... manufactured with a casing— (a) From which a belt or ply, or part thereof, is removed during processing; or (b) On which a belt or ply, or part thereof, is added or replaced during processing. S5.2.3Each retreaded...

Surface-Plasma Interaction on the Moon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horanyi, M.; Wang, X.; Robertson, S.

2008-09-07

The electrostatic levitation and transport of lunar dust remains a controversial science issue since the Apollo era. As a function of time and location, the lunar surface is exposed to solar wind plasma, UV radiation, and/or the plasma environment of our magnetosphere. Dust grains on the lunar surface emit and absorb plasma particles and are exposed to solar UV photons. There are several in situ and remote sensing observations that indicate that dusty plasma processes are responsible for the mobilization and transport of lunar soil. We briefly discuss the existing observations, and report on a series of experiments that addressmore » some of the most relevant processes acting on dusty surfaces exposed to plasmas and UV radiation.« less

Experimental study on performance of outdoor ground materials in aspect of surface temperature by constant field experiment in subtropical climate city

NASA Astrophysics Data System (ADS)

Xi, T. Y.; Ding, J. H.; Lv, X. W.; Lei, Y. S.

2018-06-01

In order to create a comfortable building thermal environment, it is important to study the outdoor ground materials performance. In this article, we carried out a constant field experiment in Guangzhou, China, studying on the variations of the surface temperature of three common outdoor building materials: concrete, pavement and grass. We put the equipment on six experiment points respectively to measure the ground surface temperature constantly. The result shows that because of the specific heat capacity, both concrete and pavement have an obvious time delay during their temperature decrease when the grass ground has almost no time delay. And when in the same conditions (exposed to sunlight all day), the material with a low specific heat capacity has a more sensitive variation in temperature. The lower the specific capacity is, the steeper the variation trend of the surface temperature will be. So compared with concrete, the pavement brick ground with a low specific heat capacity has a higher surface temperature in daytime and a lower temperature in the late night time. When in different conditions (different time exposed to sunlight), the temperature value is proportional to the time exposed to the sunlight between the same materials. The concrete exposed to sunlight all day has the highest temperature when the shaded one has the lowest. This experiment reveals that both specific heat capacity and the exposed time to sunlight has a strong influence on the surface temperature of outdoor materials. In subtropical region, the materials with a higher specific heat capacity and a less time exposed to sunlight may be more beneficial to the building thermal environment.

Transformation of plastids in soil-shaded lowermost hypocotyl segments of bean (Phaseolus vulgaris) during a 60-day cultivation period.

PubMed

Kakuszi, Andrea; Solymosi, Katalin; Böddi, Béla

2017-04-01

The maintenance but substantial transformation of plastids was found in lowermost hypocotyl segments of soil-grown bean plants (Phaseolus vulgaris cv. Magnum) during a 60-day cultivation period. Although the plants were grown under natural light-dark cycles, this hypocotyl segment was under full coverage of the soil in 5-7 cm depth, thus it was never exposed to light. The 4-day-old plants were fully etiolated: amyloplasts, occasionally prolamellar bodies, protochlorophyllide (Pchlide) and protochlorophyll (Pchl) were found in the hypocotyls of these young seedlings. The 633 and 654 nm bands in the 77 K fluorescence emission spectra indicated the presence of Pchlide and Pchl pigments. During aging, both the Pchlide and Pchl contents increased, however, the Pchl to Pchlide ratio gradually increased. In parallel, the contribution of the 654 nm form decreased and in the spectra of the 60-day-old samples, the main band shifted to 631 nm, and a new form appeared with an emission maximum at 641 nm. The photoactivity had been lost; bleaching took place at continuous illumination. The inner membranes of the plastids disappeared, the amount of starch storing amyloplasts decreased. These data may indicate the general importance of plastids for plant cell metabolism, which can be the reason for their maintenance. Also the general heterogeneity of plastid forms can be concluded: in tissues not exposed to light, Pchl accumulating plastids develop and are maintained even for a long period. © 2016 Scandinavian Plant Physiology Society.

Marketing Vegetables in Elementary School Cafeterias to Increase Uptake.

PubMed

Hanks, Andrew S; Just, David R; Brumberg, Adam

2016-08-01

Children do not eat enough servings of vegetables, underscoring the need for effective interventions encouraging this behavior. The purpose of this research was to measure the impact that daily exposure to branded vegetable characters has on vegetable selection among boys and girls in elementary schools. In a large urban school district, 10 elementary schools agreed to participate in the study. They were randomly assigned to a control condition or 1 of 3 treatment conditions: (1) a vinyl banner displaying vegetable characters that was fastened around the base of the salad bar; (2) short television segments with health education delivered by vegetable characters; or (3) a combination of the vinyl banner and television segments. We collected 22 206 student-day observations over a 6-week period by tallying the number of boys and girls taking vegetables from the school's salad bar. Results show that 90.5% (from 12.6% to 24.0%; P = .04) more students took vegetables from the salad bar when exposed to the vinyl banner only, and 239.2% (from 10.2% to 34.6%; P < .001) more students visited the salad bar when exposed to both the television segments and vinyl banners. Both boys and girls responded positively to the vinyl banners (P < .05 in both cases). Evidence from this study highlights the positive impact of branded media on children's vegetable selection in the school cafeteria. Results from this study suggest potential opportunities for using branded media to encourage healthier choices for children. Copyright © 2016 by the American Academy of Pediatrics.

Dichotomy of some satellites of the outer Solar system

NASA Astrophysics Data System (ADS)

Kochemasov, G. G.

2011-10-01

Recently acquired by the Cas as ini' CIR a temperature map (11 -16 microns radiation) of small satellite Mimas caused a perplexity among the Cassini scientists (an interpretation of PIA12867). They expected to have a regular temperature map characteristic of a homogeneous spherical body heated by Sun. Instead, the bizarre map with two sharply divided temperature fields was produced (Fig. 1). The temperature difference between two fields is about 15 Kelvin that is rather remarkable. The warm part has typical temperature near 92 Kelvin, the cold part -about 77 Kelvin. Obviously there are two icy substances with different conductivity of heat composing two planetary segments (hemispheres). But in this result there is nothing new for explorers insisting for many years that all celestial bodies are tectonically dichotomous [1, 2, 3]. However, this new beautiful confirmat ion of the wave planetology theorem 1 (" Celes tial bodies are dichotomous ") is not s uperfluous , as many s cientis ts , es pecially in the USA, are not acquainted with the wave p lanetology. The fundamental wave 1 long 2πR warping any body aris es in them becaus e they move in elliptica l keple rian orbits with periodically changing acceleration. Having in rotating bodies (but all bodies rotate!) a stationary character and four interfering directions (ortho- and diagonal) these waves inevitably produce uplifting (+), subsiding (-), and neutral (0) tectonic blocks (Fig. 7). The uplifts and subsidences are in an opposition (the best examples are the terrestrial Eastern (+) and Western ( -) segments-hemispheres and mart ian Northern (-) and Southern (+) ones) [3]. The small icy Mimas (396 km in diameter) is no exclusion (Fig. 1). Its dichotomy is well pronounced in two temperature fields obviously reflect ing slightly different in composition icy materials composing two segments. Presence of two kinds of surface materials is also revealed by spectrometry under combination of the UV, green and IR emissions (Fig. 4). Around Herschel Crater material is more bluish than more greenish elsewhere (artificial colors). Presence of dark streaks on walls o f some craters also indicates at another than pure ice substance. The deep Herschel Crater on the cooler segment is somewhat warmer than surrounding terrains (Fig. 1). Thus, one may suppose that the warmer segment exposes deeper layers and is uplifted (+), the cooler segment is subsided (-). Important confirmat ions of Mimas ' dichotomy are s imi lar geometric patterns observed on Iapetus (black & white) (Fig. 2) and on Titania (Fig. 3). Such pattern can be caught under specific viewing point s of dichotomous structure. Figures 5 and 6 show dichotomies of Rhea and Dione. Fig. 7 gives a geometrical s cheme of getting dichotomies by wave interference.

Prostate segmentation in MRI using a convolutional neural network architecture and training strategy based on statistical shape models.

PubMed

Karimi, Davood; Samei, Golnoosh; Kesch, Claudia; Nir, Guy; Salcudean, Septimiu E

2018-05-15

Most of the existing convolutional neural network (CNN)-based medical image segmentation methods are based on methods that have originally been developed for segmentation of natural images. Therefore, they largely ignore the differences between the two domains, such as the smaller degree of variability in the shape and appearance of the target volume and the smaller amounts of training data in medical applications. We propose a CNN-based method for prostate segmentation in MRI that employs statistical shape models to address these issues. Our CNN predicts the location of the prostate center and the parameters of the shape model, which determine the position of prostate surface keypoints. To train such a large model for segmentation of 3D images using small data (1) we adopt a stage-wise training strategy by first training the network to predict the prostate center and subsequently adding modules for predicting the parameters of the shape model and prostate rotation, (2) we propose a data augmentation method whereby the training images and their prostate surface keypoints are deformed according to the displacements computed based on the shape model, and (3) we employ various regularization techniques. Our proposed method achieves a Dice score of 0.88, which is obtained by using both elastic-net and spectral dropout for regularization. Compared with a standard CNN-based method, our method shows significantly better segmentation performance on the prostate base and apex. Our experiments also show that data augmentation using the shape model significantly improves the segmentation results. Prior knowledge about the shape of the target organ can improve the performance of CNN-based segmentation methods, especially where image features are not sufficient for a precise segmentation. Statistical shape models can also be employed to synthesize additional training data that can ease the training of large CNNs.

Late Holocene paleoseismology of Shuyak Island, Kodiak Archipelago, Alaska - surface deformation and plate segmentation within the 1964 Alaska M 9.2 earthquake rupture zone

NASA Astrophysics Data System (ADS)

Brader, Martin; Shennan, Ian; Barlow, Natasha; Davies, Frank; Longley, Chris; Tunstall, Neil

2017-04-01

Recent paleoseismological studies question whether segment boundaries identified for 20th and 21st century great, >M 8, earthquakes persist through multiple earthquake cycles, or whether smaller segments with different boundaries rupture and cause significant hazards. The smaller segments may include some that are currently slipping rather than locked. The 1964 Alaska M 9.2 earthquake was the largest of five earthquakes of >M 7.9 between 1938 and 1965 along the Aleutian chain and coast of southcentral Alaska that helped define models of rupture segments along the Alaska-Aleutian megathrust. The 1964 M 9.2 earthquake ruptured ˜950 km of the megathrust, involving two main asperities focussed on Kodiak Island and Prince William Sound and crossed the Kenai segment, which is currently creeping. Paleoseismic studies of coastal sediments currently provide a long record of previous large earthquakes for the Prince William Sound segment, with widespread evidence of seven great earthquakes in the last 4000 years and more restricted evidence for three earlier ones. Shorter and more fragmentary records from the Kenai Peninsula, Yakataga and Kodiak Archipelago raise the hypothesis of different patterns of surface deformation during past great earthquakes. We present new evidence from coastal wetlands on Shuyak Island, towards the hypothesised north-eastern boundary of the Kodiak segment, to illustrate different detection limits of paleoseismic indicators and how these influence the identification of segment boundaries in late Holocene earthquakes. We compare predictions of co-seismic uplift and subsidence derived from geophysical models of earthquakes with different rupture modes. The spatial patterns of agreement and misfit between model predictions and quantitative reconstructions of co-seismic submergence and emergence suggest that no earthquake within the last 4000 years had the same rupture pattern as the 1964 M 9.2 earthquake.

Translocation of Tektin 3 to the equatorial segment of heads in bull spermatozoa exposed to dibutyryl cAMP and calyculin A.

PubMed

Tsukamoto, Mariko; Hiyama, Erina; Hirotani, Karen; Gotoh, Takafumi; Inai, Tetsuichiro; Iida, Hiroshi

2017-01-01

Tektins (TEKTs) are filamentous proteins associated with microtubules in cilia, flagella, basal bodies, and centrioles. Five TEKTs (TEKT1, -2, -3, -4, and -5) have been identified as components of mammalian sperm flagella. We previously reported that TKET1 and -3 are also present in the heads of rodent spermatozoa. The present study clearly demonstrates that TEKT2 is present at the acrosome cap whereas TEKT3 resides just beneath the plasma membrane of the post-acrosomal region of sperm heads in unactivated bull spermatozoa, and builds on the distributional differences of TEKT1, -2, and -3 on sperm heads. We also discovered that hyperactivation of bull spermatozoa by cell-permeable cAMP and calyculin A, a protein phosphatase inhibitor, promoted translocation of TEKT3 from the post-acrosomal region to the equatorial segment in sperm heads, and that TEKT3 accumulated at the equatorial segment is lost upon acrosome reaction. Thus, translocation of TEKT3 to the equatorial segment may be a capacitation- or hyperactivation-associated phenomenon in bull spermatozoa. Mol. Reprod. Dev. 84: 30-43, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

The interaction between specificity and linguistic contrast

NASA Astrophysics Data System (ADS)

Nielsen, Kuniko

2005-09-01

Previous studies have shown listeners' ability to remember fine phonetic details [e.g., Mullennix et al., 1989], providing support for the episodic view of speech perception. The imitation paradigm [Goldinger, 1998, Shockley et al., 2004], in which subjects' speech is compared before and after they are exposed to target speech (= study phase) has shown that subjects shift their production in the direction of the target. Our earlier results [Nielsen, 2005] showed that the imitation effect for extended VOT was generalized to new stimuli as well as to a new segment, suggesting that the locus of the imitation effect can be smaller than individual words or segments. The current study aims to further investigate how experienced speech input interacts with linguistic representations, by testing whether the imitation effect is observed when the modeled stimuli have reduced VOT (which could introduce linguistic ambiguity). In other words, do speakers imitate and generalize shorter VOT even if the change might impair linguistic contrasts? To address this question, the study phase includes words with initial /p/ with reduced VOT, while the pre- and post-study production list includes (1) the modeled words, (2) the modeled segments /p/ in new words, and (3) the new segment /k/.

Modulation of δ-Aminolevulinic Acid Dehydratase Activity by the Sorbitol-Induced Osmotic Stress in Maize Leaf Segments.

PubMed

Jain, M; Tiwary, S; Gadre, R

2018-01-01

Osmotic stress induced with 1 M sorbitol inhibited δ-aminolevulinic acid dehydratase (ALAD) and aminolevulinic acid (ALA) synthesizing activities in etiolated maize leaf segments during greening; the ALAD activity was inhibited to a greater extent than the ALA synthesis. When the leaves were exposed to light, the ALAD activity increased for the first 8 h, followed by a decrease observed at 16 and 24 h in both sorbitol-treated and untreated leaf tissues. The maximum inhibition of the enzyme activity was observed in the leaf segments incubated with sorbitol for 4 to 8 h. Glutamate increased the ALAD activity in the in vitro enzymatic preparations obtained from the sorbitol-treated leaf segments; sorbitol inhibited the ALAD activity in the preparations from both sorbitol-treated and untreated leaves. It was suggested that sorbitol-induced osmotic stress inhibits the enzyme activity by affecting the ALAD induction during greening and regulating the ALAD steady-state level of ALAD in leaf cells. The protective effect of glutamate on ALAD in the preparations from the sorbitol-treated leaves might be due to its stimulatory effect on the enzyme.

DOE Office of Scientific and Technical Information (OSTI.GOV)

CRESSWELL,M.W.; ALLEN,R.A.; GHOSHTAGORE,R.N.

This paper describes the fabrication and measurement of the linewidths of the reference segments of cross-bridge resistors patterned in (100) Bonded and Etched Back Silicon-on-Insulator (BESOI) material. The critical dimensions (CD) of the reference segments of a selection of the cross-bridge resistor test structures were measured both electrically and by Scanning-Electron Microscopy (SEM) cross-section imaging. The reference-segment features were aligned with <110> directions in the BESOI surface material and had drawn linewidths ranging from 0.35 to 3.0 {micro}m. They were defined by a silicon micro-machining process which results in their sidewalls being atomically-planar and smooth and inclined at 54.737{degree} tomore » the surface (100) plane of the substrate. This (100) implementation may usefully complement the attributes of the previously-reported vertical-sidewall one for selected reference-material applications. For example, the non-orthogonal intersection of the sidewalls and top-surface planes of the reference-segment features may alleviate difficulties encountered with atomic-force microscope measurements. In such applications it has been reported that it may be difficult to maintain probe-tip control at the sharp 90{degree} outside corner of the sidewalls and the upper surface. A second application is refining to-down image-processing algorithms and checking instrument performance. Novel aspects of the (100) SOI implementation that are reported here include the cross-bridge resistor test-structure architecture and details of its fabrication. The long-term goal is to develop a technique for the determination of the absolute dimensions of the trapezoidal cross-sections of the cross-bridge resistors' reference segments, as a prelude to developing them for dimensional reference applications. This is believed to be the first report of electrical CD measurements made on test structures of the cross-bridge resistor type that have been patterned in (100) SOI material. The electrical CD results are compared with cross-section SEM measurements made on the same features.« less

Optimal compliant-surface jumping: a multi-segment model of springboard standing jumps.

PubMed

Cheng, Kuangyou B; Hubbard, Mont

2005-09-01

A multi-segment model is used to investigate optimal compliant-surface jumping strategies and is applied to springboard standing jumps. The human model has four segments representing the feet, shanks, thighs, and trunk-head-arms. A rigid bar with a rotational spring on one end and a point mass on the other end (the tip) models the springboard. Board tip mass, length, and stiffness are functions of the fulcrum setting. Body segments and board tip are connected by frictionless hinge joints and are driven by joint torque actuators at the ankle, knee, and hip. One constant (maximum isometric torque) and three variable functions (of instantaneous joint angle, angular velocity, and activation level) determine each joint torque. Movement from a nearly straight motionless initial posture to jump takeoff is simulated. The objective is to find joint torque activation patterns during board contact so that jump height can be maximized. Minimum and maximum joint angles, rates of change of normalized activation levels, and contact duration are constrained. Optimal springboard jumping simulations can reasonably predict jumper vertical velocity and jump height. Qualitatively similar joint torque activation patterns are found over different fulcrum settings. Different from rigid-surface jumping where maximal activation is maintained until takeoff, joint activation decreases near takeoff in compliant-surface jumping. The fulcrum-height relations in experimental data were predicted by the models. However, lack of practice at non-preferred fulcrum settings might have caused less jump height than the models' prediction. Larger fulcrum numbers are beneficial for taller/heavier jumpers because they need more time to extend joints.

Feed-forward segmentation of figure-ground and assignment of border-ownership.

PubMed

Supèr, Hans; Romeo, August; Keil, Matthias

2010-05-19

Figure-ground is the segmentation of visual information into objects and their surrounding backgrounds. Two main processes herein are boundary assignment and surface segregation, which rely on the integration of global scene information. Recurrent processing either by intrinsic horizontal connections that connect surrounding neurons or by feedback projections from higher visual areas provide such information, and are considered to be the neural substrate for figure-ground segmentation. On the contrary, a role of feedforward projections in figure-ground segmentation is unknown. To have a better understanding of a role of feedforward connections in figure-ground organization, we constructed a feedforward spiking model using a biologically plausible neuron model. By means of surround inhibition our simple 3-layered model performs figure-ground segmentation and one-sided border-ownership coding. We propose that the visual system uses feed forward suppression for figure-ground segmentation and border-ownership assignment.

Multi-fractal texture features for brain tumor and edema segmentation

NASA Astrophysics Data System (ADS)

Reza, S.; Iftekharuddin, K. M.

2014-03-01

In this work, we propose a fully automatic brain tumor and edema segmentation technique in brain magnetic resonance (MR) images. Different brain tissues are characterized using the novel texture features such as piece-wise triangular prism surface area (PTPSA), multi-fractional Brownian motion (mBm) and Gabor-like textons, along with regular intensity and intensity difference features. Classical Random Forest (RF) classifier is used to formulate the segmentation task as classification of these features in multi-modal MRIs. The segmentation performance is compared with other state-of-art works using a publicly available dataset known as Brain Tumor Segmentation (BRATS) 2012 [1]. Quantitative evaluation is done using the online evaluation tool from Kitware/MIDAS website [2]. The results show that our segmentation performance is more consistent and, on the average, outperforms other state-of-the art works in both training and challenge cases in the BRATS competition.

Shared-hole graph search with adaptive constraints for 3D optic nerve head optical coherence tomography image segmentation

PubMed Central

Yu, Kai; Shi, Fei; Gao, Enting; Zhu, Weifang; Chen, Haoyu; Chen, Xinjian

2018-01-01

Optic nerve head (ONH) is a crucial region for glaucoma detection and tracking based on spectral domain optical coherence tomography (SD-OCT) images. In this region, the existence of a “hole” structure makes retinal layer segmentation and analysis very challenging. To improve retinal layer segmentation, we propose a 3D method for ONH centered SD-OCT image segmentation, which is based on a modified graph search algorithm with a shared-hole and locally adaptive constraints. With the proposed method, both the optic disc boundary and nine retinal surfaces can be accurately segmented in SD-OCT images. An overall mean unsigned border positioning error of 7.27 ± 5.40 µm was achieved for layer segmentation, and a mean Dice coefficient of 0.925 ± 0.03 was achieved for optic disc region detection. PMID:29541497

Feed-Forward Segmentation of Figure-Ground and Assignment of Border-Ownership

PubMed Central

Supèr, Hans; Romeo, August; Keil, Matthias

2010-01-01

Figure-ground is the segmentation of visual information into objects and their surrounding backgrounds. Two main processes herein are boundary assignment and surface segregation, which rely on the integration of global scene information. Recurrent processing either by intrinsic horizontal connections that connect surrounding neurons or by feedback projections from higher visual areas provide such information, and are considered to be the neural substrate for figure-ground segmentation. On the contrary, a role of feedforward projections in figure-ground segmentation is unknown. To have a better understanding of a role of feedforward connections in figure-ground organization, we constructed a feedforward spiking model using a biologically plausible neuron model. By means of surround inhibition our simple 3-layered model performs figure-ground segmentation and one-sided border-ownership coding. We propose that the visual system uses feed forward suppression for figure-ground segmentation and border-ownership assignment. PMID:20502718

Freeze-fracture studies of photoreceptor membranes: new observations bearing upon the distribution of cholesterol

PubMed Central

1983-01-01

We performed electron microscopy of replicas from freeze-fractured retinas exposed during or after fixation to the cholesterol-binding antibiotic, filipin. We observed characteristic filipin-induced perturbations throughout the disk and plasma membranes of retinal rod outer segments of various species. It is evident that a prolonged exposure to filipin in fixative enhances rather than reduces presumptive cholesterol detection in the vertebrate photoreceptor cell. In agreement with the pattern seen in our previous study (Andrews, L.D., and A. I. Cohen, 1979, J. Cell Biol., 81:215-228), filipin- binding in membranes exhibiting particle-free patches seemed largely confined to these patches. Favorably fractured photoreceptors exhibited marked filipin-binding in apical inner segment plasma membrane topologically confluent with and proximate to the outer segment plasma membrane, which was comparatively free of filipin binding. A possible boundary between these differing membrane domains was suggested in a number of replicas exhibiting lower filipin binding to the apical plasma membrane of the inner segment in the area surrounding the cilium. This area contains a structure (Andrews, L. D., 1982, Freeze- fracture studies of vertebrate photoreceptors, In Structure of the Eye, J. G. Hollyfield and E. Acosta Vidrio, editors, Elsevier/North-Holland, New York, 11-23) that resembles the active zones of the nerve terminals for the frog neuromuscular junction. These observations lead us to hypothesize that these structures may function to direct vesicle fusion to occur near them, in a domain of membrane more closely resembling outer than inner segment plasma membrane. The above evidence supports the views that (a) all disk membranes contain cholesterol, but the particle-free patches present in some disks trap cholesterol from contiguous particulate membrane regions; (b) contiguous inner and outer segment membranes may greatly differ in cholesterol content; and (c) the suggested higher cholesterol in the inner segment than in the outer segment plasma membrane may help direct newly inserted photopigment molecules to the outer segment. PMID:6411740

Polymer dynamics under cylindrical confinement featuring a locally repulsive surface: A quasielastic neutron scattering study

DOE PAGES

Krutyeva, M.; Pasini, S.; Monkenbusch, M.; ...

2017-02-02

We investigated the effect of intermediate cylindrical confinement with locally repulsive walls on the segmental and entanglement dynamics of a polymer melt by quasielastic neutron scattering. As a reference, we measured the corresponding polymer melt under identical conditions. The locally repulsive confinement was realized by hydrophilic anodic alumina nanopores with a diameter of 20 nm. The end-to-end distance of the hydrophobic infiltrated polyethylene-alt-propylene was close to this diameter. In the case of hard wall repulsion with negligible local attraction, several simulations predicted an acceleration of segmental dynamics close to the wall. Other than in attractive or neutral systems, where themore » segmental dynamics is slowed down, we found that the segmental dynamics in the nanopores is identical to the local mobility in the bulk. Even under very careful scrutiny, we could not find any acceleration of the surface-near segmental motion. On the larger time scale, the neutron spin-echo experiment showed that the Rouse relaxation was not altered by confinement effects. Moreover, the entanglement dynamics was not affected. Thus at moderate confinement conditions, facilitated by locally repulsive walls, the dynamics remains as in the bulk melt, a result that is not so clear from simulations.« less

Method and apparatus for uniformly concentrating solar flux for photovoltaic applications

DOEpatents

Jorgensen, Gary J.; Carasso, Meir; Wendelin, Timothy J.; Lewandowski, Allan A.

1992-01-01

A dish reflector and method for concentrating moderate solar flux uniformly on a target plane on a solar cell array, the dish having a stepped reflective surface that is characterized by a plurality of ring-like segments arranged about a common axis, and each segment having a concave spherical configuration.

Wiring assembly and method of forming a channel in a wiring assembly for receiving conductor and providing separate regions of conductor contact with the channel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stelzer, Gerald; Meinke, Rainer; Senti, Mark

A conductor assembly and method for constructing an assembly of the type which, when conducting current, generates a magnetic field or which, in the presence of a changing magnetic field, induces a voltage. In one embodiment the method provides a first insulative layer tubular in shape and including a surface along which a conductor segment may be positioned. A channel formed in the surface of the insulative layer defines a first conductor path and includes a surface of first contour in cross section along a first plane transverse to the conductor path. A segment of conductor having a surface ofmore » second contour in cross section is positioned at least partly in the channel and extends along the conductor path. Along the first plane, contact between the conductor surface of second contour and the channel surface of first contour includes at least two separate regions of contact.« less

Collaborative SDOCT Segmentation and Analysis Software.

PubMed

Yun, Yeyi; Carass, Aaron; Lang, Andrew; Prince, Jerry L; Antony, Bhavna J

2017-02-01

Spectral domain optical coherence tomography (SDOCT) is routinely used in the management and diagnosis of a variety of ocular diseases. This imaging modality also finds widespread use in research, where quantitative measurements obtained from the images are used to track disease progression. In recent years, the number of available scanners and imaging protocols grown and there is a distinct absence of a unified tool that is capable of visualizing, segmenting, and analyzing the data. This is especially noteworthy in longitudinal studies, where data from older scanners and/or protocols may need to be analyzed. Here, we present a graphical user interface (GUI) that allows users to visualize and analyze SDOCT images obtained from two commonly used scanners. The retinal surfaces in the scans can be segmented using a previously described method, and the retinal layer thicknesses can be compared to a normative database. If necessary, the segmented surfaces can also be corrected and the changes applied. The interface also allows users to import and export retinal layer thickness data to an SQL database, thereby allowing for the collation of data from a number of collaborating sites.

Integrated modeling analysis of a novel hexapod and its application in active surface

NASA Astrophysics Data System (ADS)

Yang, Dehua; Zago, Lorenzo; Li, Hui; Lambert, Gregory; Zhou, Guohua; Li, Guoping

2011-09-01

This paper presents the concept and integrated modeling analysis of a novel mechanism, a 3-CPS/RPPS hexapod, for supporting segmented reflectors for radio telescopes and eventually segmented mirrors of optical telescopes. The concept comprises a novel type of hexapod with an original organization of actuators hence degrees of freedom, based on a swaying arm based design concept. Afterwards, with specially designed connecting joints between panels/segments, an iso-static master-slave active surface concept can be achieved for any triangular and/or hexagonal panel/segment pattern. The integrated modeling comprises all the multifold sizing and performance aspects which must be evaluated concurrently in order to optimize and validate the design and the configuration. In particular, comprehensive investigation of kinematic behavior, dynamic analysis, wave-front error and sensitivity analysis are carried out, where, frequently used tools like MATLAB/SimMechanics, CALFEM and ANSYS are used. Especially, we introduce the finite element method as a competent approach for analyses of the multi-degree of freedom mechanism. Some experimental verifications already performed validating single aspects of the integrated concept are also presented with the results obtained.

Self-assembled micellar aggregates based monomethoxyl poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(aminoethyl methacrylate) triblock copolymers as efficient gene delivery vectors.

PubMed

Ma, Ming; Li, Feng; Liu, Xiu-hong; Yuan, Zhe-fan; Chen, Fu-jie; Zhuo, Ren-xi

2010-10-01

Amphiphilic triblock copolymers monomethoxyl poly(ethylene glycol) (mPEG)-b-poly(ε-caprolactone) (PCL)-b-poly(aminoethyl methacrylate)s (PAMAs) (mPECAs) were synthesized as gene delivery vectors. They exhibited lower cytotoxicity and higher transfection efficiency in COS-7 cells in presence of serum compared to 25 kDa bPEI. The influence of mPEG and PCL segments in mPECAs was evaluated by comparing with corresponding diblock copolymers. The studies showed the incorporation of the hydrophobic PCL segment in triblock copolymers affected the binding capability to pDNA and surface charges of complexes due to the formation of micelles increasing the local charges. The presence of mPEG segment in gene vector decreased the surface charges of the complexes and increased the stability of the complexes in serum because of the steric hindrance effect. It was also found that the combination of PEG and PCL segments into one macromolecule might lead to synergistic effect for better transfection efficiency in serum.

Segmented lasing tube for high temperature laser assembly

DOEpatents

Sawicki, Richard H.; Alger, Terry W.; Finucane, Raymond G.; Hall, Jerome P.

1996-01-01

A high temperature laser assembly capable of withstanding operating temperatures in excess of 1500.degree. C. is described comprising a segmented cylindrical ceramic lasing tube having a plurality of cylindrical ceramic lasing tube segments of the same inner and outer diameters non-rigidly joined together in axial alignment; insulation of uniform thickness surround the walls of the ceramic lasing tube; a ceramic casing, preferably of quartz, surrounding the insulation; and a fluid cooled metal jacket surrounds the ceramic casing. In a preferred embodiment, the inner surface of each of the ceramic lasing tube segments are provided with a pair of oppositely spaced grooves in the wall thereof parallel to the center axis of the segmented cylindrical ceramic lasing tube, and both of the grooves and the center axis of the segmented cylindrical ceramic lasing tube lie in a common plane, with the grooves in each ceramic lasing tube segment in circumferential alignment with the grooves in the adjoining ceramic lasing tube segments; and one or more ceramic plates, all lying in a common plane to one another and with the central axis of the segmented ceramic lasing tube, are received in the grooves to provide additional wall area in the segmented ceramic lasing tube for collision and return to ground state of metastable metal atoms within the segmented ceramic lasing tube.

Learning of perceptual grouping for object segmentation on RGB-D data☆

PubMed Central

Richtsfeld, Andreas; Mörwald, Thomas; Prankl, Johann; Zillich, Michael; Vincze, Markus

2014-01-01

Object segmentation of unknown objects with arbitrary shape in cluttered scenes is an ambitious goal in computer vision and became a great impulse with the introduction of cheap and powerful RGB-D sensors. We introduce a framework for segmenting RGB-D images where data is processed in a hierarchical fashion. After pre-clustering on pixel level parametric surface patches are estimated. Different relations between patch-pairs are calculated, which we derive from perceptual grouping principles, and support vector machine classification is employed to learn Perceptual Grouping. Finally, we show that object hypotheses generation with Graph-Cut finds a globally optimal solution and prevents wrong grouping. Our framework is able to segment objects, even if they are stacked or jumbled in cluttered scenes. We also tackle the problem of segmenting objects when they are partially occluded. The work is evaluated on publicly available object segmentation databases and also compared with state-of-the-art work of object segmentation. PMID:24478571

Rapid Phenotyping of Root Systems of Brachypodium Plants Using X-ray Computed Tomography: a Comparative Study of Soil Types and Segmentation Tools

NASA Astrophysics Data System (ADS)

Varga, T.; McKinney, A. L.; Bingham, E.; Handakumbura, P. P.; Jansson, C.

2017-12-01

Plant roots play a critical role in plant-soil-microbe interactions that occur in the rhizosphere, as well as in processes with important implications to farming and thus human food supply. X-ray computed tomography (XCT) has been proven to be an effective tool for non-invasive root imaging and analysis. Selected Brachypodium distachyon phenotypes were grown in both natural and artificial soil mixes. The specimens were imaged by XCT, and the root architectures were extracted from the data using three different software-based methods; RooTrak, ImageJ-based WEKA segmentation, and the segmentation feature in VG Studio MAX. The 3D root image was successfully segmented at 30 µm resolution by all three methods. In this presentation, ease of segmentation and the accuracy of the extracted quantitative information (root volume and surface area) will be compared between soil types and segmentation methods. The best route to easy and accurate segmentation and root analysis will be highlighted.

All words are not created equal: Expectations about word length guide infant statistical learning

PubMed Central

Lew-Williams, Casey; Saffran, Jenny R.

2011-01-01

Infants have been described as ‘statistical learners’ capable of extracting structure (such as words) from patterned input (such as language). Here, we investigated whether prior knowledge influences how infants track transitional probabilities in word segmentation tasks. Are infants biased by prior experience when engaging in sequential statistical learning? In a laboratory simulation of learning across time, we exposed 9- and 10-month-old infants to a list of either bisyllabic or trisyllabic nonsense words, followed by a pause-free speech stream composed of a different set of bisyllabic or trisyllabic nonsense words. Listening times revealed successful segmentation of words from fluent speech only when words were uniformly bisyllabic or trisyllabic throughout both phases of the experiment. Hearing trisyllabic words during the pre-exposure phase derailed infants’ abilities to segment speech into bisyllabic words, and vice versa. We conclude that prior knowledge about word length equips infants with perceptual expectations that facilitate efficient processing of subsequent language input. PMID:22088408

Eliciting Affect via Immersive Virtual Reality: A Tool for Adolescent Risk Reduction

PubMed Central

Houck, Christopher D.; Barker, David H.; Garcia, Abbe Marrs; Spitalnick, Josh S.; Curtis, Virginia; Roye, Scott; Brown, Larry K.

2014-01-01

Objective A virtual reality environment (VRE) was designed to expose participants to substance use and sexual risk-taking cues to examine the utility of VR in eliciting adolescent physiological arousal. Methods 42 adolescents (55% male) with a mean age of 14.54 years (SD = 1.13) participated. Physiological arousal was examined through heart rate (HR), respiratory sinus arrhythmia (RSA), and self-reported somatic arousal. A within-subject design (neutral VRE, VR party, and neutral VRE) was utilized to examine changes in arousal. Results The VR party demonstrated an increase in physiological arousal relative to a neutral VRE. Examination of individual segments of the party (e.g., orientation, substance use, and sexual risk) demonstrated that HR was significantly elevated across all segments, whereas only the orientation and sexual risk segments demonstrated significant impact on RSA. Conclusions This study provides preliminary evidence that VREs can be used to generate physiological arousal in response to substance use and sexual risk cues. PMID:24365699

Proton exchange membrane materials for the advancement of direct methanol fuel-cell technology

DOEpatents

Cornelius, Christopher J [Albuquerque, NM

2006-04-04

A new class of hybrid organic-inorganic materials, and methods of synthesis, that can be used as a proton exchange membrane in a direct methanol fuel cell. In contrast with Nafion.RTM. PEM materials, which have random sulfonation, the new class of materials have ordered sulfonation achieved through self-assembly of alternating polyimide segments of different molecular weights comprising, for example, highly sulfonated hydrophilic PDA-DASA polyimide segment alternating with an unsulfonated hydrophobic 6FDA-DAS polyimide segment. An inorganic phase, e.g., 0.5 5 wt % TEOS, can be incorporated in the sulfonated polyimide copolymer to further improve its properties. The new materials exhibit reduced swelling when exposed to water, increased thermal stability, and decreased O.sub.2 and H.sub.2 gas permeability, while retaining proton conductivities similar to Nafion.RTM.. These improved properties may allow direct methanol fuel cells to operate at higher temperatures and with higher efficiencies due to reduced methanol crossover.

Image Segmentation, Registration, Compression, and Matching

NASA Technical Reports Server (NTRS)

Yadegar, Jacob; Wei, Hai; Yadegar, Joseph; Ray, Nilanjan; Zabuawala, Sakina

2011-01-01

A novel computational framework was developed of a 2D affine invariant matching exploiting a parameter space. Named as affine invariant parameter space (AIPS), the technique can be applied to many image-processing and computer-vision problems, including image registration, template matching, and object tracking from image sequence. The AIPS is formed by the parameters in an affine combination of a set of feature points in the image plane. In cases where the entire image can be assumed to have undergone a single affine transformation, the new AIPS match metric and matching framework becomes very effective (compared with the state-of-the-art methods at the time of this reporting). No knowledge about scaling or any other transformation parameters need to be known a priori to apply the AIPS framework. An automated suite of software tools has been created to provide accurate image segmentation (for data cleaning) and high-quality 2D image and 3D surface registration (for fusing multi-resolution terrain, image, and map data). These tools are capable of supporting existing GIS toolkits already in the marketplace, and will also be usable in a stand-alone fashion. The toolkit applies novel algorithmic approaches for image segmentation, feature extraction, and registration of 2D imagery and 3D surface data, which supports first-pass, batched, fully automatic feature extraction (for segmentation), and registration. A hierarchical and adaptive approach is taken for achieving automatic feature extraction, segmentation, and registration. Surface registration is the process of aligning two (or more) data sets to a common coordinate system, during which the transformation between their different coordinate systems is determined. Also developed here are a novel, volumetric surface modeling and compression technique that provide both quality-guaranteed mesh surface approximations and compaction of the model sizes by efficiently coding the geometry and connectivity/topology components of the generated models. The highly efficient triangular mesh compression compacts the connectivity information at the rate of 1.5-4 bits per vertex (on average for triangle meshes), while reducing the 3D geometry by 40-50 percent. Finally, taking into consideration the characteristics of 3D terrain data, and using the innovative, regularized binary decomposition mesh modeling, a multistage, pattern-drive modeling, and compression technique has been developed to provide an effective framework for compressing digital elevation model (DEM) surfaces, high-resolution aerial imagery, and other types of NASA data.

Method and means of reducing erosion of components of plasma devices exposed to helium and hydrogen isotope radiation

DOEpatents

Kaminsky, Manfred S.; Das, Santosh K.; Rossing, Thomas D.

1977-01-25

Surfaces of components of plasma devices exposed to radiation by atoms or ions of helium or isotopes of hydrogen can be protected from damage due to blistering by shielding the surfaces with a structure formed by sintering a powder of aluminum or beryllium and its oxide or by coating the surfaces with such a sintered metal powder.

Fourier decomposition of segmented magnets with radial magnetization in surface-mounted PM machines

NASA Astrophysics Data System (ADS)

Tiang, Tow Leong; Ishak, Dahaman; Lim, Chee Peng

2017-11-01

This paper presents a generic field model of radial magnetization (RM) pattern produced by multiple segmented magnets per rotor pole in surface-mounted permanent magnet (PM) machines. The magnetization vectors from either odd- or even-number of magnet blocks per pole are described. Fourier decomposition is first employed to derive the field model, and later integrated with the exact 2D analytical subdomain method to predict the magnetic field distributions and other motor global quantities. For the assessment purpose, a 12-slot/8-pole surface-mounted PM motor with two segmented magnets per pole is investigated by using the proposed field model. The electromagnetic performances of the PM machines are intensively predicted by the proposed magnet field model which include the magnetic field distributions, airgap flux density, phase back-EMF, cogging torque, and output torque during either open-circuit or on-load operating conditions. The analytical results are evaluated and compared with those obtained from both 2D and 3D finite element analyses (FEA) where an excellent agreement has been achieved.

Powered Flight Design and Reconstructed Performance Summary for the Mars Science Laboratory Mission

NASA Technical Reports Server (NTRS)

Sell, Steven; Chen, Allen; Davis, Jody; San Martin, Miguel; Serricchio, Frederick; Singh, Gurkirpal

2013-01-01

The Powered Flight segment of Mars Science Laboratory's (MSL) Entry, Descent, and Landing (EDL) system extends from backshell separation through landing. This segment is responsible for removing the final 0.1% of the kinetic energy dissipated during EDL and culminating with the successful touchdown of the rover on the surface of Mars. Many challenges exist in the Powered Flight segment: extraction of Powered Descent Vehicle from the backshell, performing a 300m divert maneuver to avoid the backshell and parachute, slowing the descent from 85 m/s to 0.75 m/s and successfully lowering the rover on a 7.5m bridle beneath the rocket-powered Descent Stage and gently placing it on the surface using the Sky Crane Maneuver. Finally, the nearly-spent Descent Stage must execute a Flyaway maneuver to ensure surface impact a safe distance from the Rover. This paper provides an overview of the powered flight design, key features, and event timeline. It also summarizes Curiosity's as flown performance on the night of August 5th as reconstructed by the flight team.

Real-time sensing of optical alignment

NASA Technical Reports Server (NTRS)

Stier, Mark T.; Wissinger, Alan B.

1988-01-01

The Large Deployable Reflector and other future segmented optical systems may require autonomous, real-time alignment of their optical surfaces. Researchers have developed gratings located directly on a mirror surface to provide interferometric sensing of the location and figure of the mirror. The grating diffracts a small portion of the incident beam to a diffractive focus where the designed diagnostics can be performed. Mirrors with diffraction gratings were fabricated in two separate ways. The formation of a holographic grating over the entire surface of a mirror, thereby forming a Zone Plate Mirror (ZPM) is described. Researchers have also used computer-generated hologram (CGH) patches for alignment and figure sensing of mirrors. When appropriately illuminated, a grid of patches spread over a mirror segment will yield a grid of point images at a wavefront sensor, with the relative location of the points providing information on the figure and location of the mirror. A particular advantage of using the CGH approach is that the holographic patches can be computed, fabricated, and replicated on a mirror segment in a mass production 1-g clean room environment.

Quantitative 3D Ultrashort Time-to-Echo (UTE) MRI and Micro-CT (μCT) Evaluation of the Temporomandibular Joint (TMJ) Condylar Morphology

PubMed Central

Geiger, Daniel; Bae, Won C.; Statum, Sheronda; Du, Jiang; Chung, Christine B.

2014-01-01

Objective Temporomandibular dysfunction involves osteoarthritis of the TMJ, including degeneration and morphologic changes of the mandibular condyle. Purpose of this study was to determine accuracy of novel 3D-UTE MRI versus micro-CT (μCT) for quantitative evaluation of mandibular condyle morphology. Material & Methods Nine TMJ condyle specimens were harvested from cadavers (2M, 3F; Age 85 ± 10 yrs., mean±SD). 3D-UTE MRI (TR=50ms, TE=0.05 ms, 104 μm isotropic-voxel) was performed using a 3-T MR scanner and μCT (18 μm isotropic-voxel) was performed. MR datasets were spatially-registered with μCT dataset. Two observers segmented bony contours of the condyles. Fibrocartilage was segmented on MR dataset. Using a custom program, bone and fibrocartilage surface coordinates, Gaussian curvature, volume of segmented regions and fibrocartilage thickness were determined for quantitative evaluation of joint morphology. Agreement between techniques (MRI vs. μCT) and observers (MRI vs. MRI) for Gaussian curvature, mean curvature and segmented volume of the bone were determined using intraclass correlation correlation (ICC) analyses. Results Between MRI and μCT, the average deviation of surface coordinates was 0.19±0.15 mm, slightly higher than spatial resolution of MRI. Average deviation of the Gaussian curvature and volume of segmented regions, from MRI to μCT, was 5.7±6.5% and 6.6±6.2%, respectively. ICC coefficients (MRI vs. μCT) for Gaussian curvature, mean curvature and segmented volumes were respectively 0.892, 0.893 and 0.972. Between observers (MRI vs. MRI), the ICC coefficients were 0.998, 0.999 and 0.997 respectively. Fibrocartilage thickness was 0.55±0.11 mm, as previously described in literature for grossly normal TMJ samples. Conclusion 3D-UTE MR quantitative evaluation of TMJ condyle morphology ex-vivo, including surface, curvature and segmented volume, shows high correlation against μCT and between observers. In addition, UTE MRI allows quantitative evaluation of the fibrocartilaginous condylar component. PMID:24092237

Line segment extraction for large scale unorganized point clouds

NASA Astrophysics Data System (ADS)

Lin, Yangbin; Wang, Cheng; Cheng, Jun; Chen, Bili; Jia, Fukai; Chen, Zhonggui; Li, Jonathan

2015-04-01

Line segment detection in images is already a well-investigated topic, although it has received considerably less attention in 3D point clouds. Benefiting from current LiDAR devices, large-scale point clouds are becoming increasingly common. Most human-made objects have flat surfaces. Line segments that occur where pairs of planes intersect give important information regarding the geometric content of point clouds, which is especially useful for automatic building reconstruction and segmentation. This paper proposes a novel method that is capable of accurately extracting plane intersection line segments from large-scale raw scan points. The 3D line-support region, namely, a point set near a straight linear structure, is extracted simultaneously. The 3D line-support region is fitted by our Line-Segment-Half-Planes (LSHP) structure, which provides a geometric constraint for a line segment, making the line segment more reliable and accurate. We demonstrate our method on the point clouds of large-scale, complex, real-world scenes acquired by LiDAR devices. We also demonstrate the application of 3D line-support regions and their LSHP structures on urban scene abstraction.

A supervoxel-based segmentation method for prostate MR images

NASA Astrophysics Data System (ADS)

Tian, Zhiqiang; Liu, LiZhi; Fei, Baowei

2015-03-01

Accurate segmentation of the prostate has many applications in prostate cancer diagnosis and therapy. In this paper, we propose a "Supervoxel" based method for prostate segmentation. The prostate segmentation problem is considered as assigning a label to each supervoxel. An energy function with data and smoothness terms is used to model the labeling process. The data term estimates the likelihood of a supervoxel belongs to the prostate according to a shape feature. The geometric relationship between two neighboring supervoxels is used to construct a smoothness term. A threedimensional (3D) graph cut method is used to minimize the energy function in order to segment the prostate. A 3D level set is then used to get a smooth surface based on the output of the graph cut. The performance of the proposed segmentation algorithm was evaluated with respect to the manual segmentation ground truth. The experimental results on 12 prostate volumes showed that the proposed algorithm yields a mean Dice similarity coefficient of 86.9%+/-3.2%. The segmentation method can be used not only for the prostate but also for other organs.

Segmentation of Planar Surfaces from Laser Scanning Data Using the Magnitude of Normal Position Vector for Adaptive Neighborhoods.

PubMed

Kim, Changjae; Habib, Ayman; Pyeon, Muwook; Kwon, Goo-rak; Jung, Jaehoon; Heo, Joon

2016-01-22

Diverse approaches to laser point segmentation have been proposed since the emergence of the laser scanning system. Most of these segmentation techniques, however, suffer from limitations such as sensitivity to the choice of seed points, lack of consideration of the spatial relationships among points, and inefficient performance. In an effort to overcome these drawbacks, this paper proposes a segmentation methodology that: (1) reduces the dimensions of the attribute space; (2) considers the attribute similarity and the proximity of the laser point simultaneously; and (3) works well with both airborne and terrestrial laser scanning data. A neighborhood definition based on the shape of the surface increases the homogeneity of the laser point attributes. The magnitude of the normal position vector is used as an attribute for reducing the dimension of the accumulator array. The experimental results demonstrate, through both qualitative and quantitative evaluations, the outcomes' high level of reliability. The proposed segmentation algorithm provided 96.89% overall correctness, 95.84% completeness, a 0.25 m overall mean value of centroid difference, and less than 1° of angle difference. The performance of the proposed approach was also verified with a large dataset and compared with other approaches. Additionally, the evaluation of the sensitivity of the thresholds was carried out. In summary, this paper proposes a robust and efficient segmentation methodology for abstraction of an enormous number of laser points into plane information.

Segmentation of Planar Surfaces from Laser Scanning Data Using the Magnitude of Normal Position Vector for Adaptive Neighborhoods

PubMed Central

Kim, Changjae; Habib, Ayman; Pyeon, Muwook; Kwon, Goo-rak; Jung, Jaehoon; Heo, Joon

2016-01-01

Diverse approaches to laser point segmentation have been proposed since the emergence of the laser scanning system. Most of these segmentation techniques, however, suffer from limitations such as sensitivity to the choice of seed points, lack of consideration of the spatial relationships among points, and inefficient performance. In an effort to overcome these drawbacks, this paper proposes a segmentation methodology that: (1) reduces the dimensions of the attribute space; (2) considers the attribute similarity and the proximity of the laser point simultaneously; and (3) works well with both airborne and terrestrial laser scanning data. A neighborhood definition based on the shape of the surface increases the homogeneity of the laser point attributes. The magnitude of the normal position vector is used as an attribute for reducing the dimension of the accumulator array. The experimental results demonstrate, through both qualitative and quantitative evaluations, the outcomes’ high level of reliability. The proposed segmentation algorithm provided 96.89% overall correctness, 95.84% completeness, a 0.25 m overall mean value of centroid difference, and less than 1° of angle difference. The performance of the proposed approach was also verified with a large dataset and compared with other approaches. Additionally, the evaluation of the sensitivity of the thresholds was carried out. In summary, this paper proposes a robust and efficient segmentation methodology for abstraction of an enormous number of laser points into plane information. PMID:26805849

Joint segmentation of lumen and outer wall from femoral artery MR images: Towards 3D imaging measurements of peripheral arterial disease.

PubMed

Ukwatta, Eranga; Yuan, Jing; Qiu, Wu; Rajchl, Martin; Chiu, Bernard; Fenster, Aaron

2015-12-01

Three-dimensional (3D) measurements of peripheral arterial disease (PAD) plaque burden extracted from fast black-blood magnetic resonance (MR) images have shown to be more predictive of clinical outcomes than PAD stenosis measurements. To this end, accurate segmentation of the femoral artery lumen and outer wall is required for generating volumetric measurements of PAD plaque burden. Here, we propose a semi-automated algorithm to jointly segment the femoral artery lumen and outer wall surfaces from 3D black-blood MR images, which are reoriented and reconstructed along the medial axis of the femoral artery to obtain improved spatial coherence between slices of the long, thin femoral artery and to reduce computation time. The developed segmentation algorithm enforces two priors in a global optimization manner: the spatial consistency between the adjacent 2D slices and the anatomical region order between the femoral artery lumen and outer wall surfaces. The formulated combinatorial optimization problem for segmentation is solved globally and exactly by means of convex relaxation using a coupled continuous max-flow (CCMF) model, which is a dual formulation to the convex relaxed optimization problem. In addition, the CCMF model directly derives an efficient duality-based algorithm based on the modern multiplier augmented optimization scheme, which has been implemented on a GPU for fast computation. The computed segmentations from the developed algorithm were compared to manual delineations from experts using 20 black-blood MR images. The developed algorithm yielded both high accuracy (Dice similarity coefficients ≥ 87% for both the lumen and outer wall surfaces) and high reproducibility (intra-class correlation coefficient of 0.95 for generating vessel wall area), while outperforming the state-of-the-art method in terms of computational time by a factor of ≈ 20. Copyright © 2015 Elsevier B.V. All rights reserved.

In vivo validation of cardiac output assessment in non-standard 3D echocardiographic images

NASA Astrophysics Data System (ADS)

Nillesen, M. M.; Lopata, R. G. P.; de Boode, W. P.; Gerrits, I. H.; Huisman, H. J.; Thijssen, J. M.; Kapusta, L.; de Korte, C. L.

2009-04-01

Automatic segmentation of the endocardial surface in three-dimensional (3D) echocardiographic images is an important tool to assess left ventricular (LV) geometry and cardiac output (CO). The presence of speckle noise as well as the nonisotropic characteristics of the myocardium impose strong demands on the segmentation algorithm. In the analysis of normal heart geometries of standardized (apical) views, it is advantageous to incorporate a priori knowledge about the shape and appearance of the heart. In contrast, when analyzing abnormal heart geometries, for example in children with congenital malformations, this a priori knowledge about the shape and anatomy of the LV might induce erroneous segmentation results. This study describes a fully automated segmentation method for the analysis of non-standard echocardiographic images, without making strong assumptions on the shape and appearance of the heart. The method was validated in vivo in a piglet model. Real-time 3D echocardiographic image sequences of five piglets were acquired in radiofrequency (rf) format. These ECG-gated full volume images were acquired intra-operatively in a non-standard view. Cardiac blood flow was measured simultaneously by an ultrasound transit time flow probe positioned around the common pulmonary artery. Three-dimensional adaptive filtering using the characteristics of speckle was performed on the demodulated rf data to reduce the influence of speckle noise and to optimize the distinction between blood and myocardium. A gradient-based 3D deformable simplex mesh was then used to segment the endocardial surface. A gradient and a speed force were included as external forces of the model. To balance data fitting and mesh regularity, one fixed set of weighting parameters of internal, gradient and speed forces was used for all data sets. End-diastolic and end-systolic volumes were computed from the segmented endocardial surface. The cardiac output derived from this automatic segmentation was validated quantitatively by comparing it with the CO values measured from the volume flow in the pulmonary artery. Relative bias varied between 0 and -17%, where the nominal accuracy of the flow meter is in the order of 10%. Assuming the CO measurements from the flow probe as a gold standard, excellent correlation (r = 0.99) was observed with the CO estimates obtained from image segmentation.

Fault creep and persistent asperities on the western section of the North Anatolian Fault, Turkey

NASA Astrophysics Data System (ADS)

Floyd, M.; Reilinger, R. E.; Ergintav, S.; Karabulut, H.; Vernant, P.; Konca, A. O.; Dogan, U.; Cetin, S.; Cakir, Z.; Mencin, D.; Bilham, R. G.; King, R. W.

2017-12-01

We interpret new geodetic and seismic observations along the western section of the North Anatolian Fault (NAF) in Turkey as evidence for persistent asperities on the fault surface. Analysis of geodetic and seismic observations of seven segments of the fault at different stages of the earthquake cycle suggest that areas of the fault surface that are accumulating strain (i.e. asperities) are deficient in interseismic seismicity and earthquake aftershocks compared to areas between asperities that are failing at least in part by fault creep. From west to east, these segments include the 2014 M6.9 Gokceada earthquake and 1912 M7.4 Ganos earthquake segments, the Sea of Marmara and Princes' Islands seismic "gaps", the 1999 M7.6/7.2 Izmit/Duzce earthquake segments, and the 1944 M7.4 Ismetpasa segment, which remains actively creeping. Aspects of each segment contribute to our interpretation of overall fault behavior. The most well-defined distribution of coseismic slip in relation to pre- and post-earthquake seismicity is for the 2014 Gokceada event. The most complete set of geodetic observations (pre-, co-, and short- and long-term post-seismic) come from the 1999 Izmit and Duzce events. Simple three-layer elastic models including a middle layer that is fully locked between earthquakes, and shallow and deeper layers that are allowed to creep, can account for these observations of the deformation cycle. Recent observations from InSAR, creepmeters and small-aperture GPS profiles indicate ongoing surface and shallow fault creep rates, as allowed by the upper layer of the three-layer model. Conceptually, creep in the deeper layer represents the deep healing of the fault following the earthquake. For the Izmit and Duzce earthquake segments, healing from prior earthquakes was complete before the 1999 sequence. More generally, the consistent pattern of strain accumulation along the full length of the NAF, including the long eastern segments that ruptured in major earthquakes in 1939, 1942 and 1943, suggests that deep fault healing is complete over time scales much shorter than the earthquake repeat time. Given their similarities, these results may be applicable and provide insights into the mechanics of strain accumulation and earthquake potential along other continental strike-slip faults such as the San Andreas Fault.

Formation of rings from segments of HeLa-cell nuclear deoxyribonucleic acid

PubMed Central

Hardman, Norman

1974-01-01

Duplex segments of HeLa-cell nuclear DNA were generated by cleavage with DNA restriction endonuclease from Haemophilus influenzae. About 20–25% of the DNA segments produced, when partly degraded with exonuclease III and annealed, were found to form rings visible in the electron microscope. A further 5% of the DNA segments formed structures that were branched in configuration. Similar structures were generated from HeLa-cell DNA, without prior treatment with restriction endonuclease, when the complementary polynucleotide chains were exposed by exonuclease III action at single-chain nicks. After exposure of an average single-chain length of 1400 nucleotides per terminus at nicks in HeLa-cell DNA by exonuclease III, followed by annealing, the physical length of ring closures was estimated and found to be 0.02–0.1μm, or 50–300 base pairs. An almost identical distribution of lengths was recorded for the regions of complementary base sequence responsible for branch formation. It is proposed that most of the rings and branches are formed from classes of reiterated base sequence with an average length of 180 base pairs arranged intermittenly in HeLa-cell DNA. From the rate of formation of branched structures when HeLa-cell DNA segments were heat-denatured and annealed, it is estimated that the reiterated sequences are in families containing approximately 2400–24000 copies. ImagesPLATE 2PLATE 1 PMID:4462738

A study of riders' noise exposure on Bay Area Rapid Transit trains.

PubMed

Dinno, Alexis; Powell, Cynthia; King, Margaret Mary

2011-02-01

Excessive noise exposure may present a hazard to hearing, cardiovascular, and psychosomatic health. Mass transit systems, such as the Bay Area Rapid Transit (BART) system, are potential sources of excessive noise. The purpose of this study was to characterize transit noise and riders' exposure to noise on the BART system using three dosimetry metrics. We made 268 dosimetry measurements on a convenience sample of 51 line segments. Dosimetry measures were modeled using linear and nonlinear multiple regression as functions of average velocity, tunnel enclosure, flooring, and wet weather conditions and presented visually on a map of the BART system. This study provides evidence of levels of hazardous levels of noise exposure in all three dosimetry metrics. L(eq) and L(max) measures indicate exposures well above ranges associated with increased cardiovascular and psychosomatic health risks in the published literature. L(peak) indicate acute exposures hazardous to adult hearing on about 1% of line segment rides and acute exposures hazardous to child hearing on about 2% of such rides. The noise to which passengers are exposed may be due to train-specific conditions (velocity and flooring), but also to rail conditions (velocity and tunnels). These findings may point at possible remediation (revised speed limits on longer segments and those segments enclosed by tunnels). The findings also suggest that specific rail segments could be improved for noise.

Hyperplasia of the submucosal glands of the columnar-lined oesophagus.

PubMed

Lörinc, Ester; Öberg, Stefan

2015-04-01

To evaluate the presence of multi-layered epithelium (ME) and to compare the distribution, size and morphology of the oesophageal submucosal glands (SMG) beneath reflux exposed metaplastic columnar mucosa with those of normal squamous epithelium in patients with columnar-lined oesophagus (CLO). In eight oesophageal resection specimens, the SMG of the metaplastic segments were significantly larger than those in the squamous segments of patients with CLO (0.81 versus 0.56 mm(2) , P = <0.001). There was an accumulation of SMG close to the neosquamocolumnar junction (NSCJ), as indicated by a higher median frequency of SMG (0.080 SMG/mm) compared with that of the squamous (0.013 SMG/mm) and metaplastic segments (0.031 SMG/mm) (P = 0.022). The frequency of ME was significantly higher in the metaplastic compared with the normal squamous segments (1/158 mm and 1/341 mm, respectively, P = 0.028) and ME was found almost exclusively (96%) in direct connection with the excretory ducts of SMG. Hyperplasia of SMG in the metaplastic segment, accumulation of SMG near the NSCJ, the presence of ME in connection with the excretory ducts of SMG and metaplasia are all reflux-induced morphological changes, possibly induced by stimulation of progenitors in the excretory ducts of the SMG. © 2014 John Wiley & Sons Ltd.

Recuperator construction for a gas turbine engine

DOEpatents

Kang, Yungmo; McKeirnan, Jr., Robert D.

2006-12-12

A counter-flow recuperator formed from annular arrays of recuperator core segments. The recuperator core segments are formed from two opposing sheets of fin fold material coined to form a primary surface zone disposed between two flattened manifold zones. Each primary surface zone has undulating corrugations including a uniform, full height central portion and a transition zone disposed between the central portion and one of the manifold zones. Corrugations of the transition zone rise from zero adjacent to the manifold zone and increase along a transition length to full crest height at the central portion. The transition lengths increase in a direction away from an inner edge containing the air inlet so as to equalize air flow to the distal regions of the primary surface zone.

Effect of antimony incorporation on the density, shape, and luminescence of InAs quantum dots

NASA Astrophysics Data System (ADS)

Chen, J. F.; Chiang, C. H.; Wu, Y. H.; Chang, L.; Chi, J. Y.

2008-07-01

This work investigates the surfactant effect on exposed and buried InAs quantum dots (QDs) by incorporating Sb into the QD layers with various Sb beam equivalent pressures (BEPs). Secondary ion mass spectroscopy shows the presence of Sb in the exposed and buried QD layers with the Sb intensity in the exposed layer substantially exceeding that in the buried layer. Incorporating Sb can reduce the density of the exposed QDs by more than two orders of magnitude. However, a high Sb BEP yields a surface morphology with a regular periodic structure of ellipsoid terraces. A good room-temperature photoluminescence (PL) at ˜1600 nm from the exposed QDs is observed, suggesting that the Sb incorporation probably improves the emission efficiency by reducing the surface recombination velocity at the surface of the exposed QDs. Increasing Sb BEP causes a blueshift of the emission from the exposed QDs due to a reduction in the dot height as suggested by atomic force microscopy. Increasing Sb BEP can also blueshift the ˜1300 nm emission from the buried QDs by decreasing the dot height. However, a high Sb BEP yields a quantum well-like PL feature formed by the clustering of the buried QDs into an undulated planar layer. These results indicate a marked Sb surfactant effect that can be used to control the density, shape, and luminescence of the exposed and buried QDs.

The use of atlas registration and graph cuts for prostate segmentation in magnetic resonance images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korsager, Anne Sofie, E-mail: asko@hst.aau.dk; Østergaard, Lasse Riis; Fortunati, Valerio

2015-04-15

Purpose: An automatic method for 3D prostate segmentation in magnetic resonance (MR) images is presented for planning image-guided radiotherapy treatment of prostate cancer. Methods: A spatial prior based on intersubject atlas registration is combined with organ-specific intensity information in a graph cut segmentation framework. The segmentation is tested on 67 axial T{sub 2}-weighted MR images in a leave-one-out cross validation experiment and compared with both manual reference segmentations and with multiatlas-based segmentations using majority voting atlas fusion. The impact of atlas selection is investigated in both the traditional atlas-based segmentation and the new graph cut method that combines atlas andmore » intensity information in order to improve the segmentation accuracy. Best results were achieved using the method that combines intensity information, shape information, and atlas selection in the graph cut framework. Results: A mean Dice similarity coefficient (DSC) of 0.88 and a mean surface distance (MSD) of 1.45 mm with respect to the manual delineation were achieved. Conclusions: This approaches the interobserver DSC of 0.90 and interobserver MSD 0f 1.15 mm and is comparable to other studies performing prostate segmentation in MR.« less

Sparse intervertebral fence composition for 3D cervical vertebra segmentation

NASA Astrophysics Data System (ADS)

Liu, Xinxin; Yang, Jian; Song, Shuang; Cong, Weijian; Jiao, Peifeng; Song, Hong; Ai, Danni; Jiang, Yurong; Wang, Yongtian

2018-06-01

Statistical shape models are capable of extracting shape prior information, and are usually utilized to assist the task of segmentation of medical images. However, such models require large training datasets in the case of multi-object structures, and it also is difficult to achieve satisfactory results for complex shapes. This study proposed a novel statistical model for cervical vertebra segmentation, called sparse intervertebral fence composition (SiFC), which can reconstruct the boundary between adjacent vertebrae by modeling intervertebral fences. The complex shape of the cervical spine is replaced by a simple intervertebral fence, which considerably reduces the difficulty of cervical segmentation. The final segmentation results are obtained by using a 3D active contour deformation model without shape constraint, which substantially enhances the recognition capability of the proposed method for objects with complex shapes. The proposed segmentation framework is tested on a dataset with CT images from 20 patients. A quantitative comparison against corresponding reference vertebral segmentation yields an overall mean absolute surface distance of 0.70 mm and a dice similarity index of 95.47% for cervical vertebral segmentation. The experimental results show that the SiFC method achieves competitive cervical vertebral segmentation performances, and completely eliminates inter-process overlap.

Repair of bone segment defects with surface porous fiber-reinforced polymethyl methacrylate (PMMA) composite prosthesis: histomorphometric incorporation model and characterization by SEM.

PubMed

Hautamäki, Mikko P; Aho, Allan J; Alander, Pasi; Rekola, Jami; Gunn, Jarmo; Strandberg, Niko; Vallittu, Pekka K

2008-08-01

Polymer technology has provided solutions for filling of bone defects in situations where there may be technical or biological complications with autografts, allografts, and metal prostheses. We present an experimental study on segmental bone defect reconstruction using a polymethylmethacrylate-(PMMA-) based bulk polymer implant prosthesis. We concentrated on osteoconductivity and surface characteristics. A critical size segment defect of the rabbit tibia in 19 animals aged 18-24 weeks was reconstructed with a surface porous glass fiber-reinforced (SPF) prosthesis made of polymethylmethacrylate (PMMA). The biomechanical properties of SPF implant material were previously adjusted technically to mimic the properties of normal cortical bone. A plain PMMA implant with no porosity or fiber reinforcement was used as a control. Radiology, histomorphometry, and scanning electron microscopy (SEM) were used for analysis of bone growth into the prosthesis during incorporation. The radiographic and histological incorporation model showed good host bone contact, and strong formation of new bone as double cortex. Histomorphometric evaluation showed that the bone contact index (BCI) at the posterior surface interface was higher with the SPF implant than for the control. The total appositional bone growth over the posterior surface (area %) was also stronger for the SPF implant than for controls. Both bone growth into the porous surface and the BCI results were related to the quality, coverage, and regularity of the microstructure of the porous surface. Porous surface structure enhanced appositional bone growth onto the SPF implant. Under load-bearing conditions the implant appears to function like an osteoconductive prosthesis, which enables direct mobilization and rapid return to full weight bearing.

The Gabbs Valley, Nevada, geothermal prospect: Exploring for a potential blind geothermal resource

NASA Astrophysics Data System (ADS)

Payne, J.; Bell, J. W.; Calvin, W. M.

2012-12-01

The Gabbs Valley prospect in west-central Nevada is a potential blind geothermal resource system. Possible structural controls on this system were investigated using high-resolution LiDAR, low sun-angle aerial (LSA) photography, exploratory fault trenching and a shallow temperature survey. Active Holocene faults have previously been identified at 37 geothermal systems with indication of temperatures greater than 100° C in the western Nevada region. Active fault controls in Gabbs Valley include both Holocene and historical structures. Two historical earthquakes occurring in 1932 and 1954 have overlapping surface rupture patterns in Gabbs Valley. Three active fault systems identified through LSA and LiDAR mapping have characteristics of Basin and Range normal faulting and Walker Lane oblique dextral faulting. The East Monte Cristo Mountains fault zone is an 8.5 km long continuous NNE striking, discrete fault with roughly 0.5 m right-normal historic motion and 3 m vertical Quaternary separation. The Phillips Wash fault zone is an 8.2 km long distributed fault system striking NE to N, with Quaternary fault scarps of 1-3 m vertical separation and a 500 m wide graben adjacent to the Cobble Cuesta anticline. This fault displays ponded drainages, an offset terrace riser and right stepping en echelon fault patterns suggestive of left lateral offset, and fault trenching exposed non-matching stratigraphy typical of a significant component of lateral offset. The unnamed faults of Gabbs Valley are a 10.6 km long system of normal faults striking NNE and Quaternary scarps are up to 4 m high. These normal faults largely do not have historic surface rupture, but a small segment of 1932 rupture has been identified. A shallow (2 m deep) temperature survey of 80 points covering roughly 65 square kilometers was completed. Data were collected over approximately 2 months, and continual base station temperature measurements were used to seasonally correct temperature measurements. A 2.5 km long temperature anomaly greater than 3° C above background temperatures forms west-northwest trending zone between terminations of the Phillips Wash fault zone and unnamed faults of Gabbs Valley to the south. Rupture segments of two young active faults bracket the temperature anomaly. The temperature anomaly may be due to several possible causes. 1. Increases in stress near the rupture segments or tip-lines of these faults, or where multiple fault splays exist, can increase fault permeability. The un-ruptured segments of these faults may be controlling the location of the Gabbs Valley thermal anomaly between ruptured segments of the 1932 Cedar Mountain and 1954 Fairview Peak earthquakes. 2. Numerous unnamed normal faults may interact and the hanging wall of these faults is hosting the thermal anomaly. The size and extent of the anomaly may be due to its proximity to a flat playa and not the direct location of the shallow heat anomaly. 3. The linear northwest nature of the thermal anomaly may reflect a hydrologic barrier in the subsurface controlling where heated fluids rise. A concealed NW- striking fault is possible, but has not been identified in previous studies or in the LiDAR or LSA fault mapping.

Wavefront control of large optical systems

NASA Technical Reports Server (NTRS)

Meinel, Aden B.; Meinel, Marjorie P.; Breckinridge, J. B.

1990-01-01

Several levels of wavefront control are necessary for the optimum performance of very large telescopes, especially segmented ones like the Large Deployable Reflector. In general, the major contributors to wavefront error are the segments of the large primary mirror. Wavefront control at the largest optical surface may not be the optimum choice because of the mass and inaccessibility of the elements of this surface that require upgrading. The concept of two-stage optics was developed to permit a poor wavefront from the large optics to be upgraded by means of a wavefront corrector at a small exit pupil of the system.

Structural characteristics and implication on tectonic evolution of the Daerbute strike-slip fault in West Junggar area, NW China

NASA Astrophysics Data System (ADS)

Wu, Kongyou; Pei, Yangwen; Li, Tianran; Wang, Xulong; Liu, Yin; Liu, Bo; Ma, Chao; Hong, Mei

2018-03-01

The Daerbute fault zone, located in the northwestern margin of the Junggar basin, in the Central Asian Orogenic Belt, is a regional strike-slip fault with a length of 400 km. The NE-SW trending Daerbute fault zone presents a distinct linear trend in plain view, cutting through both the Zair Mountain and the Hala'alate Mountain. Because of the intense contraction and shearing, the rocks within the fault zone experienced high degree of cataclasis, schistosity, and mylonization, resulting in rocks that are easily eroded to form a valley with a width of 300-500 m and a depth of 50-100 m after weathering and erosion. The well-exposed outcrops along the Daerbute fault zone present sub-horizontal striations and sub-vertical fault steps, indicating sub-horizontal shearing along the observed fault planes. Flower structures and horizontal drag folds are also observed in both the well-exposed outcrops and high-resolution satellite images. The distribution of accommodating strike-slip splay faults, e.g., the 973-pluton fault and the Great Jurassic Trough fault, are in accordance with the Riedel model of simple shear. The seismic and time-frequency electromagnetic (TFEM) sections also demonstrate the typical strike-slip characteristics of the Daerbute fault zone. Based on detailed field observations of well-exposed outcrops and seismic sections, the Daerbute fault can be subdivided into two segments: the western segment presents multiple fault cores and damage zones, whereas the eastern segment only presents a single fault core, in which the rocks experienced a higher degree of rock cataclasis, schistosity, and mylonization. In the central overlapping portion between the two segments, the sediments within the fault zone are primarily reddish sandstones, conglomerates, and some mudstones, of which the palynological tests suggest middle Permian as the timing of deposition. The deformation timing of the Daerbute fault was estimated by integrating the depocenters' basinward migration and initiation of the splay faults (e.g., the Great Jurassic Trough fault and the 973-pluton fault). These results indicate that there were probably two periods of faulting deformation for the Daerbute fault. By integrating our study with previous studies, we speculate that the Daerbute fault experienced a two-phase strike-slip faulting deformation, commencing with the initial dextral strike-slip faulting in mid-late Permian, and then being inversed to sinistral strike-slip faulting since the Triassic. The results of this study can provide useful insights for the regional tectonics and local hydrocarbon exploration.

Beam-hardening correction by a surface fitting and phase classification by a least square support vector machine approach for tomography images of geological samples

NASA Astrophysics Data System (ADS)

Khan, F.; Enzmann, F.; Kersten, M.

2015-12-01

In X-ray computed microtomography (μXCT) image processing is the most important operation prior to image analysis. Such processing mainly involves artefact reduction and image segmentation. We propose a new two-stage post-reconstruction procedure of an image of a geological rock core obtained by polychromatic cone-beam μXCT technology. In the first stage, the beam-hardening (BH) is removed applying a best-fit quadratic surface algorithm to a given image data set (reconstructed slice), which minimizes the BH offsets of the attenuation data points from that surface. The final BH-corrected image is extracted from the residual data, or the difference between the surface elevation values and the original grey-scale values. For the second stage, we propose using a least square support vector machine (a non-linear classifier algorithm) to segment the BH-corrected data as a pixel-based multi-classification task. A combination of the two approaches was used to classify a complex multi-mineral rock sample. The Matlab code for this approach is provided in the Appendix. A minor drawback is that the proposed segmentation algorithm may become computationally demanding in the case of a high dimensional training data set.

Topographic association of angioscopic yellow plaques with coronary atherosclerotic plaque: assessment with quantitative colorimetry in human coronary artery autopsy specimens.

PubMed

Ishibashi, Fumiyuki; Lisauskas, Jennifer B; Kawamura, Akio; Waxman, Sergio

2008-01-01

Yellow plaques seen during coronary angioscopy are thought to be the surrogates for superficial intimal lipids in coronary plaque. Given diffuse and heterogeneous nature of atherosclerosis, yellow plaques in coronaries may be seen as several yellow spots on diffuse coronary plaque. We examined the topographic association of yellow plaques with coronary plaque. In 40 non-severely stenotic ex-vivo coronary segments (average length: 52.2 +/- 3.1 mm), yellow plaques were examined by angioscopy with quantitative colorimetry. The segments were cut perpendicular to the long axis of the vessel at 2 mm intervals, and 1045 slides with 5 microm thick tissue for whole segments were prepared. To construct the plaque surface, each tissue slice was considered to be representative of the adjacent 2 mm. The circumference of the lumen and the lumen border of plaque were measured in each slide, and the plaque surface region was constructed. Coronary plaque was in 37 (93%) of 40 segments, and consisted of a single mass [39.9 +/- 3.9 (0-100) mm, 311.3 +/- 47.4 (0.0-1336.2) mm2]. In 30 (75%) segments, multiple (2-9) yellow plaques were detected on a mass of coronary plaque. The number of yellow plaques correlated positively with coronary plaque surface area (r = 0.77, P < 0.0001). Yellow plaques in coronaries detected by angioscopy with quantitative colorimetry, some of them are associated with lipid cores underneath thin fibrous caps, may be used to assess the extent of coronary plaque. Further research using angioscopy could be of value to study the association of high-risk coronaries with acute coronary syndromes.

Design And Development The Ixo Mirrors By Innovative Slumping Glass Technologies

NASA Astrophysics Data System (ADS)

Pareschi, Giovanni; Ghigo, M.; Basso, S.; Citterio, O.; Canestrari, R.; Dell'Orto, E.; Conconi, P.; Parodi, G.; Proserpio, L.

2009-01-01

At INAF Brera Astronomical Observatory development activities are ongoing aiming at the design and development of the IXO mirrors based on slumping glass technique. Our approach is based on the use of thermal slumping of thin glass optics and it presents a number of innovative solution for the implementation. In particular our approach foresees the use of a ceramic mould made of SiC for thermal shaping of the glass segments, which occurs exerting a proper pressure during the moulding process. A thin layer (a few hundred Angstroms) of Pt or Ir is previously deposited on the glass segment, to prevent the adhesion on the SiC mould surface. Therefore this coating not only acts as a release agent of the process but, at the same time, it has also the role of reflecting layer of the X-ray mirror (in a sense like it was the role of gold in the Ni electroforming replication method used for the XMM shells). SiC is chosen for its very good T/M characteristics and, in particular, a very high thermal conductivity and very low CTE. SiC mould will be produced via injection moulding process, followed by a the application of a cladding layer (a few tens microns) application of CVD SiC for allowing a superpolishing of the surface until a roughness of a few Angstrom rms is achieved. Once the mirror segments are produced, they are integrated in petals by means of air-bearings supports, that allows us to maintain the proper shape of the segments without deformations. The segments are stacked into the petals by the use of connecting ribs, glued to the front surface of each mirror and to the rear of the next one.

Morphological patterns of the collateral sulcus in the human brain.

PubMed

Huntgeburth, Sonja C; Petrides, Michael

2012-04-01

The collateral sulcal complex is an important landmark on the medial surface of the temporal lobe. Anteriorly, it delineates the limbic regions of the parahippocampal gyrus from the visual-processing areas of the fusiform gyrus. Posteriorly, it continues into the occipital lobe, bearing no relationship to the memory-related limbic regions. Given the considerable extent of the sulcus and functional heterogeneity of the surrounding cortex, an investigation of the morphology of this sulcus was carried out to examine whether it is continuous or a series of sulcal parts, i.e. independent sulci classified together under the name collateral sulcus. We investigated the collateral sulcal complex using magnetic resonance images taking into account the three-dimensional nature of the brain. Our examination demonstrated three separate sulcal segments: (i) an anterior segment, the rhinal sulcus, delineating the uncus from the adjacent temporal neocortex, (ii) a middle segment, the collateral sulcus proper, forming the lateral border of the posterior parahippocampal cortex, and (iii) a caudal segment, the occipital extent of the collateral sulcus, within the occipital lobe. Three relationships exist between the rhinal sulcus and collateral sulcus proper, only one being clearly identifiable from the surface. Posteriorly, the collateral sulcus proper and the occipital collateral sulcus, although appearing continuous on the brain surface, can be separated in the depth of the sulcus in all cases. These results provide quantification of the location and variability within standard stereotaxic space for the three collateral sulcus segments that could be used to aid accurate identification of functional activation peaks derived from neuroimaging studies. © 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

A minimally interactive method to segment enlarged lymph nodes in 3D thoracic CT images using a rotatable spiral-scanning technique

NASA Astrophysics Data System (ADS)

Wang, Lei; Moltz, Jan H.; Bornemann, Lars; Hahn, Horst K.

2012-03-01

Precise size measurement of enlarged lymph nodes is a significant indicator for diagnosing malignancy, follow-up and therapy monitoring of cancer diseases. The presence of diverse sizes and shapes, inhomogeneous enhancement and the adjacency to neighboring structures with similar intensities, make the segmentation task challenging. We present a semi-automatic approach requiring minimal user interactions to fast and robustly segment the enlarged lymph nodes. First, a stroke approximating the largest diameter of a specific lymph node is drawn manually from which a volume of interest (VOI) is determined. Second, Based on the statistical analysis of the intensities on the dilated stroke area, a region growing procedure is utilized within the VOI to create an initial segmentation of the target lymph node. Third, a rotatable spiral-scanning technique is proposed to resample the 3D boundary surface of the lymph node to a 2D boundary contour in a transformed polar image. The boundary contour is found by seeking the optimal path in 2D polar image with dynamic programming algorithm and eventually transformed back to 3D. Ultimately, the boundary surface of the lymph node is determined using an interpolation scheme followed by post-processing steps. To test the robustness and efficiency of our method, a quantitative evaluation was conducted with a dataset of 315 lymph nodes acquired from 79 patients with lymphoma and melanoma. Compared to the reference segmentations, an average Dice coefficient of 0.88 with a standard deviation of 0.08, and an average absolute surface distance of 0.54mm with a standard deviation of 0.48mm, were achieved.

Wavefront Compensation Segmented Mirror Sensing and Control

NASA Technical Reports Server (NTRS)

Redding, David C.; Lou, John Z.; Kissil, Andrew; Bradford, Charles M.; Woody, David; Padin, Stephen

2012-01-01

The primary mirror of very large submillimeter-wave telescopes will necessarily be segmented into many separate mirror panels. These panels must be continuously co-phased to keep the telescope wavefront error less than a small fraction of a wavelength, to ten microns RMS (root mean square) or less. This performance must be maintained continuously across the full aperture of the telescope, in all pointing conditions, and in a variable thermal environment. A wavefront compensation segmented mirror sensing and control system, consisting of optical edge sensors, Wavefront Compensation Estimator/Controller Soft ware, and segment position actuators is proposed. Optical edge sensors are placed two per each segment-to-segment edge to continuously measure changes in segment state. Segment position actuators (three per segment) are used to move the panels. A computer control system uses the edge sensor measurements to estimate the state of all of the segments and to predict the wavefront error; segment actuator commands are computed that minimize the wavefront error. Translational or rotational motions of one segment relative to the other cause lateral displacement of the light beam, which is measured by the imaging sensor. For high accuracy, the collimator uses a shaped mask, such as one or more slits, so that the light beam forms a pattern on the sensor that permits sensing accuracy of better than 0.1 micron in two axes: in the z or local surface normal direction, and in the y direction parallel to the mirror surface and perpendicular to the beam direction. Using a co-aligned pair of sensors, with the location of the detector and collimated light source interchanged, four degrees of freedom can be sensed: transverse x and y displacements, as well as two bending angles (pitch and yaw). In this approach, each optical edge sensor head has a collimator and an imager, placing one sensor head on each side of a segment gap, with two parallel light beams crossing the gap. Two sets of optical edge sensors are used per segment-to-segment edge, separated by a finite distance along the segment edge, for four optical heads, each with an imager and a collimator. By orienting the beam direction of one edge sensor pair to be +45 away from the segment edge direction, and the other sensor pair to be oriented -45 away from the segment edge direction, all six degrees of freedom of relative motion between the segments can be measured with some redundancy. The software resides in a computer that receives each of the optical edge sensor signals, as well as telescope pointing commands. It feeds back the edge sensor signals to keep the primary mirror figure within specification. It uses a feed-forward control to compensate for global effects such as decollimation of the primary and secondary mirrors due to gravity sag as the telescope pointing changes to track science objects. Three segment position actuators will be provided per segment to enable controlled motions in the piston, tip, and tilt degrees of freedom. These actuators are driven by the software, providing the optical changes needed to keep the telescope phased.

Generating Ground Reference Data for a Global Impervious Surface Survey

NASA Technical Reports Server (NTRS)

Tilton, James C.; De Colstoun, Eric Brown; Wolfe, Robert E.; Tan, Bin; Huang, Chengquan

2012-01-01

We are developing an approach for generating ground reference data in support of a project to produce a 30m impervious cover data set of the entire Earth for the years 2000 and 2010 based on the Landsat Global Land Survey (GLS) data set. Since sufficient ground reference data for training and validation is not available from ground surveys, we are developing an interactive tool, called HSegLearn, to facilitate the photo-interpretation of 1 to 2 m spatial resolution imagery data, which we will use to generate the needed ground reference data at 30m. Through the submission of selected region objects and positive or negative examples of impervious surfaces, HSegLearn enables an analyst to automatically select groups of spectrally similar objects from a hierarchical set of image segmentations produced by the HSeg image segmentation program at an appropriate level of segmentation detail, and label these region objects as either impervious or nonimpervious.

Magnetic light cloaking control in the marine planktonic copepod Sapphirina

NASA Astrophysics Data System (ADS)

Kashiwagi, H.; Mizukawa, Y.; Iwasaka, M.; Ohtsuka, S.

2017-05-01

We investigated the light cloaking behavior of the marine planktonic copepod Sapphirina under a magnetic field. Optical interferences in the multi-laminated guanine crystal layer beneath the dorsal body surface create a brilliant structural color, which can be almost entirely removed by changing the light reflection. In the investigation, we immersed segments of Sapphirina in seawater contained in an optical chamber. When the derived Sapphirina segments were attached to the container surface, they were inert to magnetic fields up to 300 mT. However, when the back plate segments were attached to the substrate at a point, with most of the plate floating in the seawater, the plate rotated oppositely to the applied magnetic field. In addition, the brilliant parts of the Sapphirina back plate rotated backward and forward by changing the magnetic field directions. Our experiment suggests a new model of an optical micro-electro-mechanical system that is controllable by magnetic fields.

Particulate reduction in ternary-compound film growth via pulsed laser deposition from segmented binary-targets

NASA Astrophysics Data System (ADS)

Grant-Jacob, James A.; Prentice, Jake J.; Beecher, Stephen J.; Shepherd, David P.; Eason, Robert W.; Mackenzie, Jacob I.

2018-03-01

We present the hetero-epitaxial growth of high-quality crystalline Y3Ga5O12 onto a 〈100〉-oriented YAG substrate via pulsed laser deposition, using mixed ternary-compound and segmented binary-compound targets. We observe that a Y3Ga5O12 film fabricated using a segmented target (Y2O3/Ga2O3) contained ∼100 times fewer scattering points than a film grown using a mixed Y3Ga5O12 target. We show that following ablation, the surface of the mixed compound (ternary) target had laser-induced cone structures, whereas the surface of single compound (binary) targets did not. It is concluded that the different ablation dynamics of the oxide constituents in the respective targets plays a significant role in the origin of the scattering points in the resultant films.

A Novel Surface Structure Consisting of Contact-active Antibacterial Upper-layer and Antifouling Sub-layer Derived from Gemini Quaternary Ammonium Salt Polyurethanes.

PubMed

He, Wei; Zhang, Yi; Li, Jiehua; Gao, Yunlong; Luo, Feng; Tan, Hong; Wang, Kunjie; Fu, Qiang

2016-08-26

Contact-active antibacterial surfaces play a vital role in preventing bacterial contamination of artificial surfaces. In the past, numerous researches have been focused on antibacterial surfaces comprising of antifouling upper-layer and antibacterial sub-layer. In this work, we demonstrate a reversed surface structure which integrate antibacterial upper-layer and antifouling sub-layer. These surfaces are prepared by simply casting gemini quaternary ammonium salt waterborne polyurethanes (GWPU) and their blends. Due to the high interfacial energy of gemini quaternary ammonium salt (GQAS), chain segments containing GQAS can accumulate at polymer/air interface to form an antibacterial upper-layer spontaneously during the film formation. Meanwhile, the soft segments composed of polyethylene glycol (PEG) formed the antifouling sub-layer. Our findings indicate that the combination of antibacterial upper-layer and antifouling sub-layer endow these surfaces strong, long-lasting antifouling and contact-active antibacterial properties, with a more than 99.99% killing efficiency against both gram-positive and gram-negative bacteria attached to them.

A Novel Surface Structure Consisting of Contact-active Antibacterial Upper-layer and Antifouling Sub-layer Derived from Gemini Quaternary Ammonium Salt Polyurethanes

PubMed Central

He, Wei; Zhang, Yi; Li, Jiehua; Gao, Yunlong; Luo, Feng; Tan, Hong; Wang, Kunjie; Fu, Qiang

2016-01-01

Contact-active antibacterial surfaces play a vital role in preventing bacterial contamination of artificial surfaces. In the past, numerous researches have been focused on antibacterial surfaces comprising of antifouling upper-layer and antibacterial sub-layer. In this work, we demonstrate a reversed surface structure which integrate antibacterial upper-layer and antifouling sub-layer. These surfaces are prepared by simply casting gemini quaternary ammonium salt waterborne polyurethanes (GWPU) and their blends. Due to the high interfacial energy of gemini quaternary ammonium salt (GQAS), chain segments containing GQAS can accumulate at polymer/air interface to form an antibacterial upper-layer spontaneously during the film formation. Meanwhile, the soft segments composed of polyethylene glycol (PEG) formed the antifouling sub-layer. Our findings indicate that the combination of antibacterial upper-layer and antifouling sub-layer endow these surfaces strong, long-lasting antifouling and contact-active antibacterial properties, with a more than 99.99% killing efficiency against both gram-positive and gram-negative bacteria attached to them. PMID:27561546

Epidermal segmentation in high-definition optical coherence tomography.

PubMed

Li, Annan; Cheng, Jun; Yow, Ai Ping; Wall, Carolin; Wong, Damon Wing Kee; Tey, Hong Liang; Liu, Jiang

2015-01-01

Epidermis segmentation is a crucial step in many dermatological applications. Recently, high-definition optical coherence tomography (HD-OCT) has been developed and applied to imaging subsurface skin tissues. In this paper, a novel epidermis segmentation method using HD-OCT is proposed in which the epidermis is segmented by 3 steps: the weighted least square-based pre-processing, the graph-based skin surface detection and the local integral projection-based dermal-epidermal junction detection respectively. Using a dataset of five 3D volumes, we found that this method correlates well with the conventional method of manually marking out the epidermis. This method can therefore serve to effectively and rapidly delineate the epidermis for study and clinical management of skin diseases.

Hydrogel Ring for Topical Drug Delivery to the Ocular Posterior Segment.

PubMed

Shikamura, Yuko; Yamazaki, Yoshiko; Matsunaga, Toru; Sato, Takao; Ohtori, Akira; Tojo, Kakuji

2016-05-01

To investigate the efficacy of a topical hydrogel ring for drug delivery to the posterior segment of the rabbit eye. Novel hydrogel corneal lenses (CL), scleral/corneal lenses (S/CL), and rings were prepared using poly(hydroxyethyl methacrylate). The devices were immersed in 0.3% ofloxacin ophthalmic solution (OOS) to homogeneously distribute the drug throughout the hydrogel. The medicated CL, S/CL, Ring 1 (standard ring), or Ring 2 (shape-optimized ring) was applied to the surface of the cornea, cornea/bulbar conjunctiva, or bulbar conjunctiva of albino rabbits, respectively. Medicated rings did not touch the corneal surface. In another group, one OOS drop was administered to the eye. After 0.25-8 hours, the hydrogel devices were removed and ocular tissues were harvested. High-performance liquid chromatography (HPLC) was used to measure the ofloxacin concentration in the devices and tissues. The drug concentrations in the posterior segment tissues were compared among ofloxacin delivery methods. One hour after placement, eyes treated with Ring 1 or S/CL had markedly higher ofloxacin levels in the posterior segment tissues (conjunctiva, sclera, and retina/choroid) than eyes treated with topical OOS or a CL. Lower levels of ofloxacin were found in anterior segment tissues (cornea and aqueous humor) in eyes treated with Ring 1 compared to those treated with S/CL. Ring 2 most effectively delivered ofloxacin to the retina/choroid. The tissue ofloxacin concentration in the fellow eye was markedly lower than the eye treated with Ring 2. Our results suggest that hydrogel rings are effective in delivering topical ophthalmic drugs to the posterior segment. The drugs are most likely delivered via the transconjunctival/scleral route by lateral diffusion across the bulbar conjunctiva and through the sclera. Systemic drug delivery to the posterior segment is minimal.

Automatic cortical thickness analysis on rodent brain

NASA Astrophysics Data System (ADS)

Lee, Joohwi; Ehlers, Cindy; Crews, Fulton; Niethammer, Marc; Budin, Francois; Paniagua, Beatriz; Sulik, Kathy; Johns, Josephine; Styner, Martin; Oguz, Ipek

2011-03-01

Localized difference in the cortex is one of the most useful morphometric traits in human and animal brain studies. There are many tools and methods already developed to automatically measure and analyze cortical thickness for the human brain. However, these tools cannot be directly applied to rodent brains due to the different scales; even adult rodent brains are 50 to 100 times smaller than humans. This paper describes an algorithm for automatically measuring the cortical thickness of mouse and rat brains. The algorithm consists of three steps: segmentation, thickness measurement, and statistical analysis among experimental groups. The segmentation step provides the neocortex separation from other brain structures and thus is a preprocessing step for the thickness measurement. In the thickness measurement step, the thickness is computed by solving a Laplacian PDE and a transport equation. The Laplacian PDE first creates streamlines as an analogy of cortical columns; the transport equation computes the length of the streamlines. The result is stored as a thickness map over the neocortex surface. For the statistical analysis, it is important to sample thickness at corresponding points. This is achieved by the particle correspondence algorithm which minimizes entropy between dynamically moving sample points called particles. Since the computational cost of the correspondence algorithm may limit the number of corresponding points, we use thin-plate spline based interpolation to increase the number of corresponding sample points. As a driving application, we measured the thickness difference to assess the effects of adolescent intermittent ethanol exposure that persist into adulthood and performed t-test between the control and exposed rat groups. We found significantly differing regions in both hemispheres.

Effects of Microwave Radiation on Humans. Monkeys Exposed to 1.25 GHZ pulsed Microwaves

DTIC Science & Technology

1992-03-13

matter. The entire retina was examined by indirect ophthalmoscopy. Photographic documentation included photomicrographs of the corneal endothelial cells...segment and retina appear normal. Photos of corneal endothelium pre and post irradiation demonstrated no change. The retinal photos also appeared normal...and photographic documentation. However, baseline fluorescein angiograms of the retina and iris were also included. It was determined that baseline

Communicating Coastal Risk Analysis in an Age of Climate Change

DTIC Science & Technology

2011-10-01

extratropical storm systems); the geometry and geomorphology of the area (regional and local bathymetry and topography, including rivers, marshes, and...at risk from coastal hazards including storm surge inundation, precipitation driven flooding, waves, and coastal erosion. This population segment...will likely be exposed to increased risk as impacts of a changing climate are felt through elevated sea levels and potentially increased storm

Atlas-based segmentation technique incorporating inter-observer delineation uncertainty for whole breast

NASA Astrophysics Data System (ADS)

Bell, L. R.; Dowling, J. A.; Pogson, E. M.; Metcalfe, P.; Holloway, L.

2017-01-01

Accurate, efficient auto-segmentation methods are essential for the clinical efficacy of adaptive radiotherapy delivered with highly conformal techniques. Current atlas based auto-segmentation techniques are adequate in this respect, however fail to account for inter-observer variation. An atlas-based segmentation method that incorporates inter-observer variation is proposed. This method is validated for a whole breast radiotherapy cohort containing 28 CT datasets with CTVs delineated by eight observers. To optimise atlas accuracy, the cohort was divided into categories by mean body mass index and laterality, with atlas’ generated for each in a leave-one-out approach. Observer CTVs were merged and thresholded to generate an auto-segmentation model representing both inter-observer and inter-patient differences. For each category, the atlas was registered to the left-out dataset to enable propagation of the auto-segmentation from atlas space. Auto-segmentation time was recorded. The segmentation was compared to the gold-standard contour using the dice similarity coefficient (DSC) and mean absolute surface distance (MASD). Comparison with the smallest and largest CTV was also made. This atlas-based auto-segmentation method incorporating inter-observer variation was shown to be efficient (<4min) and accurate for whole breast radiotherapy, with good agreement (DSC>0.7, MASD <9.3mm) between the auto-segmented contours and CTV volumes.

WPC Product Legends - Surface fronts and precipitation areas/symbols

Science.gov Websites

, etc...) drawn on each segment. For example, the image below shows a forming cold front. Frontolysis is other segment. Below is an example of a dissipating warm front. Precipitation Areas and Symbols Areas of an example) Below are symbols found on our short range forecasts that represent categories (and in

Light-Emitting Diodes and Cool White Fluorescent Light Similarly Suppress Pineal Gland Melatonin and Maintain Retinal Function and Morphology in the Rat. Part 1

NASA Technical Reports Server (NTRS)

Holley, Daniel C.; Heeke, D.; Mele, G.

1999-01-01

Currently, the light sources most commonly used in animal habitat lighting are cool white fluorescent or incandescent lamps. We evaluated a novel light-emitting diode (LED) light source for use in animal habitat lighting by comparing its effectiveness to cool white fluorescent light (CWF) in suppressing pineal gland melatonin and maintaining normal retinal physiology and morphology in the rat. Results of pineal melatonin suppression experiments showed equal suppression of pineal melatonin concentrations for LED light and CWF light at five different light illuminances (100, 40, 10, 1 and 0.1 lux). There were no significant differences in melatonin suppression between LED and CWF light when compared to unexposed controls. Retinal physiology was evaluated using electroretinography. Results show no differences in a-wave implicit times and amplitudes or b-wave implicit times and amplitudes between 100-lux LED-exposed rats and 100-lux CWF-exposed rats. Results of retinal histology assessment show no differences in retinal thickness rod outer segment length and number of rod nuclei between rats exposed to 100-lux LED and 100-lux CWF for days. Furthermore, the retinal pigmented epithelium and rod outer segments of all eyes observed were in good condition and of normal thickness. This study indicates that LED light does not cause retinal damage and can suppress pineal melatonin at similar intensities as a conventional CWF light source. These data suggest that LED light sources may be suitable replacements for conventional light sources used in the lighting of rodent vivariums while providing many mechanical and economical advantages.

Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles.

PubMed

Jensen, Ditte Marie; Christophersen, Daniel Vest; Sheykhzade, Majid; Skovsted, Gry Freja; Lykkesfeldt, Jens; Münter, Rasmus; Roursgaard, Martin; Loft, Steffen; Møller, Peter

2018-02-26

Humans are continuously exposed to particles in the gastrointestinal tract. Exposure may occur directly through ingestion of particles via food or indirectly by removal of inhaled material from the airways by the mucociliary clearance system. We examined the effects of food-grade particle exposure on vasomotor function and systemic oxidative stress in an ex vivo study and intragastrically exposed rats. In an ex vivo study, aorta rings from naïve Sprague-Dawley rats were exposed for 30 min to food-grade TiO 2 (E171), benchmark TiO 2 (Aeroxide P25), food-grade vegetable carbon (E153) or benchmark carbon black (Printex 90). Subsequently, the vasomotor function was assessed in wire myographs. In an in vivo study, lean Zucker rats were exposed intragastrically once a week for 10 weeks to vehicle, E171 or E153. Doses were comparable to human daily intake. Vasomotor function in the coronary arteries and aorta was assessed using wire myographs. Tetrahydrobiopterin, ascorbate, malondialdehyde and asymmetric dimethylarginine were measured in blood as markers of oxidative stress and vascular function. Direct exposure of E171 to aorta rings ex vivo increased the acetylcholine-induced vasorelaxation and 5-hydroxytryptamine-induced vasocontraction. E153 only increased acetylcholine-induced vasorelaxation, and Printex 90 increased the 5-hydroxytryptamine-induced vasocontraction, whereas Aeroxide P25 did not affect the vasomotor function. In vivo exposure showed similar results as ex vivo exposure; increased acetylcholine-induced vasorelaxation in coronary artery segments of E153 and E171 exposed rats, whereas E171 exposure altered 5-hydroxytryptamine-induced vasocontraction in distal coronary artery segments. Plasma levels of markers of oxidative stress and vascular function showed no differences between groups. Gastrointestinal tract exposure to E171 and E153 was associated with modest albeit statistically significant alterations in the vasocontraction and vasorelaxation responses. Direct particle exposure to aorta rings elicited a similar type of response. The vasomotor responses were not related to biomarkers of systemic oxidative stress.

Immunogenicity of Membrane-bound HIV-1 gp41 Membrane-proximal External Region (MPER) Segments Is Dominated by Residue Accessibility and Modulated by Stereochemistry*

PubMed Central

Kim, Mikyung; Song, Likai; Moon, James; Sun, Zhen-Yu J.; Bershteyn, Anna; Hanson, Melissa; Cain, Derek; Goka, Selasie; Kelsoe, Garnett; Wagner, Gerhard; Irvine, Darrell; Reinherz, Ellis L.

2013-01-01

Structural characterization of epitope-paratope pairs has contributed to the understanding of antigenicity. By contrast, few structural studies relate to immunogenicity, the process of antigen-induced immune responses in vivo. Using a lipid-arrayed membrane-proximal external region (MPER) of HIV-1 glycoprotein 41 as a model antigen, we investigated the influence of physicochemical properties on immunogenicity in relation to structural modifications of MPER/liposome vaccines. Anchoring the MPER to the membrane via an alkyl tail or transmembrane domain retained the MPER on liposomes in vivo, while preserving MPER secondary structure. However, structural modifications that affected MPER membrane orientation and antigenic residue accessibility strongly impacted induced antibody responses. The solvent-exposed MPER tryptophan residue (Trp-680) was immunodominant, focusing immune responses, despite sequence variability elsewhere. Nonetheless, immunogenicity could be readily manipulated using site-directed mutagenesis or structural constraints to modulate amino acid surface display. These studies provide fundamental insights for immunogen design aimed at targeting B cell antibody responses. PMID:24047898

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency

PubMed Central

Le Blanc, Alexander; Mahrhold, Stefan; Piesker, Janett; Luppa, Peter B.

2018-01-01

The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. One peculiarity is an exposed hydrophobic loop in the toxin’s cell binding domain HC, which is located between the ganglioside- and protein receptor-binding sites, and that is particularly pronounced in the serotypes BoNT/B, DC, and G sharing synaptotagmin as protein receptor. Here, we provide evidence that this HC loop is a critical component of their tripartite receptor recognition complex. Binding to nanodisc-embedded receptors and toxicity were virtually abolished in BoNT mutants lacking residues at the tip of the HC loop. Surface plasmon resonance experiments revealed that only insertion of the HC loop into the lipid-bilayer compensates for the entropic penalty inflicted by the dual-receptor binding. Our results represent a new paradigm of how BoNT/B, DC, and G employ ternary interactions with a protein, ganglioside, and lipids to mediate their extraordinary neurotoxicity. PMID:29718991

Geologic map of the Basque-Cantabrian Basin and a new tectonic interpretation of the Basque Arc

NASA Astrophysics Data System (ADS)

Ábalos, B.

2016-11-01

A new printable 1/200.000 bedrock geological map of the onshore Basque-Cantabrian Basin is presented, aimed to contribute to future geologic developments in the central segment of the Pyrenean-Cantabrian Alpine orogenic system. It is accompanied in separate appendixes by a historic report on the precedent geological maps and by a compilation above 350 bibliographic citations of maps and academic reports (usually overlooked or ignored) that are central to this contribution. Structural scrutiny of the map permits to propose a new tectonic interpretation of the Basque Arc, implementing previously published partial reconstructions. It is presented as a printable 1/400.000 tectonic map. The Basque Arc consists of various thrust slices that can expose at the surface basement rocks (Palaeozoic to Lower Triassic) and their sedimentary cover (uppermost Triassic to Tertiary), from which they are detached by intervening (Upper Triassic) evaporites and associated rocks. The slice-bounding thrusts are in most cases reactivated normal faults active during Meso-Cenozoic sedimentation that can be readily related to basement discontinuities generated during the Hercynian orogeny.

Along-axis steps in Ethiopian rift Bouguer gravity anomalies: Implications for crustal thinning and melt emplacement prior to breakup

NASA Astrophysics Data System (ADS)

Ebinger, C. J.; Tiberi, C.; Fowler, M. R.; Hunegnaw, A.

2001-12-01

The southern Afar depression, Africa, is virtually the only area worldwide where the transition from continental rifting to seafloor spreading is exposed onshore. During mid-Miocene to Pleistocene time the rift valley was segmented along its length by long normal faults; since Pleistocene time, faulting and magmatism have jumped to a narrow ca. 60 km-long volcanic mound marked by small faults. These magmatic segments are structurally similar to slow-spreading mid-ocean ridges, yet the rift is floored by continental crust. As part of the Ethiopia Afar Geoscientific Lithospheric Experiment (EAGLE), we examine new and existing Bouguer gravity anomaly data from the rift to study the modification of the lithosphere by extensional and magmatic processes. New and existing Bouguer gravity anomaly data also show an along-axis segmentation of elongate relative positive anomalies that coincide with the magmatic segments. These anomalies are superposed on a regionally eastward increasing field as one approaches true seafloor spreading in the Gulf of Aden, and crustal thickness decreases. Quite remarkably, the magmatic segment boundaries, where data coverage is good, are marked by 15-25 mGal steps. The amplitude of the along-axis steps, as well as their across-axis characteristics, indicate that magmatic intrusion and ca. 2 km relief at the crust-mantle interface contribute to the steps. We use inverse and forward models of gravity data constrained by existing seismic and petrological data to evaluate models for the along-axis steps. EAGLE seismic data will be acquired across and along the magmatic segments to improve our understanding of breakup processes.

The retina visual cycle is driven by cis retinol oxidation in the outer segments of cones

PubMed Central

Sato, Shinya; Frederiksen, Rikard; Cornwall, M. Carter; Kefalov, Vladimir J.

2017-01-01

Vertebrate rod and cone photoreceptors require continuous supply of chromophore for regenerating their visual pigments after photoactivation. Cones, which mediate our daytime vision, demand a particularly rapid supply of 11-cis retinal chromophore in order to maintain their function in bright light. An important contribution to this process is thought to be the chromophore precursor 11-cis retinol, which is supplied to cones from Müller cells in the retina and subsequently oxidized to 11-cis retinal as part of the retina visual cycle. However, the molecular identity of the cis retinol oxidase in cones remains unclear. Here, as a first step in characterizing this enzymatic reaction, we sought to determine the subcellular localization of this activity in salamander red cones. We found that the onset of dark adaptation of isolated salamander red cones was substantially faster when exposing directly their outer vs. their inner segment to 9-cis retinol, an analogue of 11-cis retinol. In contrast, this difference was not observed when treating the outer vs. inner segment with 9-cis retinal, a chromophore analogue which can directly support pigment regeneration. These results suggest, surprisingly, that the cis-retinol oxidation occurs in the outer segments of cone photoreceptors. Confirming this notion, pigment regeneration with exogenously added 9-cis retinol was directly observed in the truncated outer segments of cones, but not in rods. We conclude that the enzymatic machinery required for the oxidation of recycled cis retinol as part of the retina visual cycle is present in the outer segments of cones. PMID:28359344

Hirudin (desulfated, 54-65) contracts canine coronary arteries: extracellular calcium influx mediates hirudin-induced contractions.

PubMed

Sorajja, Paul; Cable, David G; Hamner, Chad E; Schaff, Hartzell V

2004-09-01

Although the anticoagulatory properties of hirudin are well known, its direct vasoactive effects have not been investigated extensively. Hirudin stimulates nitric oxide and prostacyclin production in noncoronary vascular beds, but its actions on coronary arteries are unknown. Five-millimeter segments of canine left circumflex coronary arteries were obtained for organ chamber experiments. Some segments were denuded of endothelium before study. Segments were exposed to hirudin (10(-10)-10(-6) mol/L) following precontraction with prostaglandin F(2alpha) with or without pretreatment with indomethacin or calcium channel blockers (verapamil and nifedipine). Hirudin stimulated endothelium-independent contraction in coronary arterial segments. Maximum tension (hirudin 10(-6) mol/L) above precontraction baseline was 33.6 +/- 9.0% (n = 10, P < 0.05) for endothelium-intact and 31.8 +/- 11.5% (n = 8, P < 0.05) for endothelium-denuded arterial segments. Differences between endothelium-intact and endothelium-denuded segments were not significant. Contractile responses to hirudin were unaffected by the presence of indomethacin. Pretreatment with either verapamil or nifedipine (10(-4) mol/L) for 1 h attenuated these contractions. The maximal increase in tension above baseline (hirudin 10(-6) mol/L) for verapamil and nifedipine was only 6.2 +/- 12.4 and 3.8 +/- 7.0% (n = 6, P < 0.05 versus endothelium-intact control), respectively. Hirudin stimulates endothelium-independent contractions of canine coronary arteries in vitro. Pretreatment with calcium channel blockers attenuates this response, suggesting that extracellular influx of calcium has an important mechanistic role in hirudin-mediated coronary artery constriction.

Aspheric figure generation using feedback from an infrared phase-shifting interferometer

NASA Astrophysics Data System (ADS)

Stahl, H. P.; Ketelsen, D.

An infrared phase-shifting interferometric system has been integrated with a novel optical figure generator at the University of Arizona Optical Sciences Center. This unique generator facility can produce generalized axially symmetric surface figures in a timely and cost-effective manner. The success of this facility depends on both its ability to efficiently remove material while forming the surface figure, and its ability to monitor the surface figure during the generation process to provide feedback to the optician. The facility has been used on several occasions to custom-generate off-axis parabolic segments. Figures to within 0.30 microns rms of the desired figure have been obtained. This paper discusses the usefulness of the infrared phase-shifting interferometric system for providing figure correcting feedback to the optician during the generation of the off-axis parabolic segments, and how it is affected by the surface roughness produced by each generator tool.

Patellar segmentation from 3D magnetic resonance images using guided recursive ray-tracing for edge pattern detection

NASA Astrophysics Data System (ADS)

Cheng, Ruida; Jackson, Jennifer N.; McCreedy, Evan S.; Gandler, William; Eijkenboom, J. J. F. A.; van Middelkoop, M.; McAuliffe, Matthew J.; Sheehan, Frances T.

2016-03-01

The paper presents an automatic segmentation methodology for the patellar bone, based on 3D gradient recalled echo and gradient recalled echo with fat suppression magnetic resonance images. Constricted search space outlines are incorporated into recursive ray-tracing to segment the outer cortical bone. A statistical analysis based on the dependence of information in adjacent slices is used to limit the search in each image to between an outer and inner search region. A section based recursive ray-tracing mechanism is used to skip inner noise regions and detect the edge boundary. The proposed method achieves higher segmentation accuracy (0.23mm) than the current state-of-the-art methods with the average dice similarity coefficient of 96.0% (SD 1.3%) agreement between the auto-segmentation and ground truth surfaces.

Freesurfer-initialized large deformation diffeomorphic metric mapping with application to Parkinson's disease

NASA Astrophysics Data System (ADS)

Chen, Jingyun; Palmer, Samantha J.; Khan, Ali R.; Mckeown, Martin J.; Beg, Mirza Faial

2009-02-01

We apply a recently developed automated brain segmentation method, FS+LDDMM, to brain MRI scans from Parkinson's Disease (PD) subjects, and normal age-matched controls and compare the results to manual segmentation done by trained neuroscientists. The data set consisted of 14 PD subjects and 12 age-matched control subjects without neurologic disease and comparison was done on six subcortical brain structures (left and right caudate, putamen and thalamus). Comparison between automatic and manual segmentation was based on Dice Similarity Coefficient (Overlap Percentage), L1 Error, Symmetrized Hausdorff Distance and Symmetrized Mean Surface Distance. Results suggest that FS+LDDMM is well-suited for subcortical structure segmentation and further shape analysis in Parkinson's Disease. The asymmetry of the Dice Similarity Coefficient over shape change is also discussed based on the observation and measurement of FS+LDDMM segmentation results.

Modification of the Surface Properties of Polyimide Films using POSS Deposition and Oxygen Plasma Exposure

NASA Technical Reports Server (NTRS)

Wohl, Christopher J.; Belcher, Marcus A.; Ghose, Sayata; Connell, John W.

2008-01-01

Topographically rich surfaces were generated by spray-coating organic solutions of a polyhedral oligomeric silsesquioxane, octakis (dimethylsilyloxy) silsesquioxane (POSS), on Kapton HN films and exposing them to radio frequency generated oxygen plasma. Changes in both surface chemistry and topography were observed. High-resolution scanning electron microscopy indicated substantial modification of the POSS-coated polyimide surface topographies as a result of oxygen plasma exposure. Water contact angles varied from 104 deg for unexposed POSS-coated surfaces to approximately 5 deg, for samples exposed for 5 h. Modulation of the dispersive and polar contributions to the surface energy was determined using van Oss Good Chaudhury theory.

Space environment and lunar surface processes

NASA Technical Reports Server (NTRS)

Comstock, G. M.

1979-01-01

The development of a general rock/soil model capable of simulating in a self consistent manner the mechanical and exposure history of an assemblage of solid and loose material from submicron to planetary size scales, applicable to lunar and other space exposed planetary surfaces is discussed. The model was incorporated into a computer code called MESS.2 (model for the evolution of space exposed surfaces). MESS.2, which represents a considerable increase in sophistication and scope over previous soil and rock surface models, is described. The capabilities of previous models for near surface soil and rock surfaces are compared with the rock/soil model, MESS.2.

Inorganic-organic shape memory polymers and foams for bone defect repairs

NASA Astrophysics Data System (ADS)

Zhang, Dawei

The ultimate goal of this research was to develop a "self-fitting" shape memory polymer (SMP) scaffold for the repair of craniomaxillofacial (CMF) bone defects. CMF defects may be caused by trauma, tumor removal or congenital abnormalities and represent a major class of bone defects. Their repair with autografts is limited by availability, donor site morbidity and complex surgical procedures. In addition, shaping and positioning of these rigid grafts into irregular defects is difficult. Herein, we have developed SMP scaffolds which soften at T > ˜56 °C, allowing them to conformally fit into a bone defect. Upon cooling to body temperature, the scaffold becomes rigid and mechanically locks in place. This research was comprised of four major studies. In the first study, photocrosslinkable acrylated (AcO) SMP macromers containing a poly(epsilon-caprolactone) (PCL) segment and polydimethylsiloxane (PDMS) segments were synthesized with the general formula: AcO-PCL40-block-PDMS m-block-PCL40-OAc. By varying the PDMS segment length (m), solid SMPs with highly tunable mechanical properties and excellent shape memory abilities were prepared. In the second study, porous SMP scaffolds were fabricated based on AcO-PCL 40-block-PDMS37-block-PCL 40-OAc via a revised solvent casting particulate leaching (SCPL) method. By tailoring scaffold parameters including salt fusion, macromer concentration and salt size, scaffold properties (e.g. pore features, compressive modulus and shape memory behavior) were tuned. In the third study, porous SMP scaffolds were produced from macromers with variable PDMS segment lengths (m = 0 -- 130) via an optimized SCPL method. The impact on pore features, thermal, mechanical, and shape memory properties as well as degradation rates were investigated. In the final study, a bioactive polydopamine coating was applied onto pore surfaces of the SMP scaffold prepared from PCL diacrylate. The thin coating did not affect intrinsic bulk properties of the scaffold. However, the coating significantly increased its bioactivity, giving rise to the formation of "bone-bonding" hydroxyapatite (HAp) when exposed to simulated body fluid (SBF). It was also shown that the coating largely enhanced the scaffold's capacities to support osteoblasts adhesion, proliferation and osteogenesis. Thus, the polydopamine coating should enhance the performance of the "self-fitting" SMP scaffolds for the repair of bone defects.

Vessel segmentation in 3D spectral OCT scans of the retina

NASA Astrophysics Data System (ADS)

Niemeijer, Meindert; Garvin, Mona K.; van Ginneken, Bram; Sonka, Milan; Abràmoff, Michael D.

2008-03-01

The latest generation of spectral optical coherence tomography (OCT) scanners is able to image 3D cross-sectional volumes of the retina at a high resolution and high speed. These scans offer a detailed view of the structure of the retina. Automated segmentation of the vessels in these volumes may lead to more objective diagnosis of retinal vascular disease including hypertensive retinopathy, retinopathy of prematurity. Additionally, vessel segmentation can allow color fundus images to be registered to these 3D volumes, possibly leading to a better understanding of the structure and localization of retinal structures and lesions. In this paper we present a method for automatically segmenting the vessels in a 3D OCT volume. First, the retina is automatically segmented into multiple layers, using simultaneous segmentation of their boundary surfaces in 3D. Next, a 2D projection of the vessels is produced by only using information from certain segmented layers. Finally, a supervised, pixel classification based vessel segmentation approach is applied to the projection image. We compared the influence of two methods for the projection on the performance of the vessel segmentation on 10 optic nerve head centered 3D OCT scans. The method was trained on 5 independent scans. Using ROC analysis, our proposed vessel segmentation system obtains an area under the curve of 0.970 when compared with the segmentation of a human observer.

Apparatus and method for carbon fiber surface treatment

DOEpatents

Paulauskas, Felix L; Sherman, Daniel M

2014-06-03

An apparatus and method for enhancing the surface energy and/or surface chemistry of carbon fibers involves exposing the fibers to direct or indirect contact with atmospheric pressure plasma generated using a background gas containing at least some oxygen or other reactive species. The fiber may be exposed directly to the plasma, provided that the plasma is nonfilamentary, or the fiber may be exposed indirectly through contact with gases exhausting from a plasma discharge maintained in a separate volume. In either case, the process is carried out at or near atmospheric pressure, thereby eliminating the need for vacuum equipment. The process may be further modified by moistening the fibers with selected oxygen-containing liquids before exposure to the plasma.

Apparatus and method for carbon fiber surface treatment

DOEpatents

Paulauskas, Felix L [Knoxville, TN; Sherman, Daniel M [Knoxville, TN

2012-07-24

An apparatus and method for enhancing the surface energy and/or surface chemistry of carbon fibers involves exposing the fibers to direct or indirect contact with atmospheric pressure plasma generated using a background gas containing at least some oxygen or other reactive species. The fiber may be exposed directly to the plasma, provided that the plasma is nonfilamentary, or the fiber may be exposed indirectly through contact with gases exhausting from a plasma discharge maintained in a separate volume. In either case, the process is carried out at or near atmospheric pressure, thereby eliminating the need for vacuum equipment. The process may be further modified by moistening the fibers with selected oxygen-containing liquids before exposure to the plasma.

A multi-directional and multi-scale roughness filter to detect lineament segments on digital elevation models - analyzing spatial objects in R

NASA Astrophysics Data System (ADS)

Baumann, Sebastian; Robl, Jörg; Wendt, Lorenz; Willingshofer, Ernst; Hilberg, Sylke

2016-04-01

Automated lineament analysis on remotely sensed data requires two general process steps: The identification of neighboring pixels showing high contrast and the conversion of these domains into lines. The target output is the lineaments' position, extent and orientation. We developed a lineament extraction tool programmed in R using digital elevation models as input data to generate morphological lineaments defined as follows: A morphological lineament represents a zone of high relief roughness, whose length significantly exceeds the width. As relief roughness any deviation from a flat plane, defined by a roughness threshold, is considered. In our novel approach a multi-directional and multi-scale roughness filter uses moving windows of different neighborhood sizes to identify threshold limited rough domains on digital elevation models. Surface roughness is calculated as the vertical elevation difference between the center cell and the different orientated straight lines connecting two edge cells of a neighborhood, divided by the horizontal distance of the edge cells. Thus multiple roughness values depending on the neighborhood sizes and orientations of the edge connecting lines are generated for each cell and their maximum and minimum values are extracted. Thereby negative signs of the roughness parameter represent concave relief structures as valleys, positive signs convex relief structures as ridges. A threshold defines domains of high relief roughness. These domains are thinned to a representative point pattern by a 3x3 neighborhood filter, highlighting maximum and minimum roughness peaks, and representing the center points of lineament segments. The orientation and extent of the lineament segments are calculated within the roughness domains, generating a straight line segment in the direction of least roughness differences. We tested our algorithm on digital elevation models of multiple sources and scales and compared the results visually with shaded relief map of these digital elevation models. The lineament segments trace the relief structure to a great extent and the calculated roughness parameter represents the physical geometry of the digital elevation model. Modifying the threshold for the surface roughness value highlights different distinct relief structures. Also the neighborhood size at which lineament segments are detected correspond with the width of the surface structure and may be a useful additional parameter for further analysis. The discrimination of concave and convex relief structures perfectly matches with valleys and ridges of the surface.

Surface displacement based shape analysis of central brain structures in preterm-born children

NASA Astrophysics Data System (ADS)

Garg, Amanmeet; Grunau, Ruth E.; Popuri, Karteek; Miller, Steven; Bjornson, Bruce; Poskitt, Kenneth J.; Beg, Mirza Faisal

2016-03-01

Many studies using T1 magnetic resonance imaging (MRI) data have found associations between changes in global metrics (e.g. volume) of brain structures and preterm birth. In this work, we use the surface displacement feature extracted from the deformations of the surface models of the third ventricle, fourth ventricle and brainstem to capture the variation in shape in these structures at 8 years of age that may be due to differences in the trajectory of brain development as a result of very preterm birth (24-32 weeks gestation). Understanding the spatial patterns of shape alterations in these structures in children who were born very preterm as compared to those who were born at full term may lead to better insights into mechanisms of differing brain development between these two groups. The T1 MRI data for the brain was acquired from children born full term (FT, n=14, 8 males) and preterm (PT, n=51, 22 males) at age 8-years. Accurate segmentation labels for these structures were obtained via a multi-template fusion based segmentation method. A high dimensional non-rigid registration algorithm was utilized to register the target segmentation labels to a set of segmentation labels defined on an average-template. The surface displacement data for the brainstem and the third ventricle were found to be significantly different (p < 0.05) between the PT and FT groups. Further, spatially localized clusters with inward and outward deformation were found to be associated with lower gestational age. The results from this study present a shape analysis method for pediatric MRI data and reveal shape changes that may be due to preterm birth.

Optical and Scanning Electron Microscopy of the Materials International Space Station Experiment (MISSE) Spacecraft Silicone Experiment

NASA Technical Reports Server (NTRS)

Hung, Ching-cheh; de Groh, Kim K.; Banks, Bruce A.

2012-01-01

Under a microscope, atomic oxygen (AO) exposed silicone surfaces are crazed and seen as "islands" separated by numerous crack lines, much analogous to mud-tile cracks. This research characterized and compared the degree of AO degradation of silicones by analyzing optical microscope images of samples exposed to low Earth orbit (LEO) AO as part of the Spacecraft Silicone Experiment. The Spacecraft Silicone Experiment consisted of eight DC 93-500 silicone samples exposed to eight different AO fluence levels (ranged from 1.46 to 8.43 10(exp 21) atoms/sq cm) during two different Materials International Space Station Experiment (MISSE) missions. Image analysis software was used to analyze images taken using a digital camera. To describe the morphological degradation of each AO exposed flight sample, three different parameters were selected and estimated: (1) average area of islands was determined and found to be in the 1000 to 3100 sq mm range; (2) total length of crack lines per unit area of the sample surface were determined and found to be in the range of 27 to 59 mm of crack length per sq mm of sample surface; and (3) the fraction of sample surface area that is occupied by crack lines was determined and found to be in the 25 to 56 percent range. In addition, average crack width can be estimated from crack length and crack area measurements and was calculated to be about 10 mm. Among the parameters studied, the fraction of sample surface area that is occupied by crack lines is believed to be most useful in characterizing the degree of silicone conversion to silicates by AO because its value steadily increases with increasing fluence over the entire fluence range. A series of SEM images from the eight samples exposed to different AO fluences suggest a complex sequence of surface stress due to surface shrinkage and crack formation, followed by re-distribution of stress and shrinking rate on the sample surface. Energy dispersive spectra (EDS) indicated that upon AO exposure, carbon content on the surface decreased relatively quickly at the beginning, to 32 percent of the pristine value for the least exposed sample in this set of experiments (1.46 10(exp 21) atoms/sq cm), but then decreased slowly, to 22 percent of the pristine value for the most exposed sample in this set of experiment (8.43 10(exp 21) atoms/sq cm). The oxygen content appears to increase at a slower rate. The least and most AO exposed samples were, respectively, 52 and 150 percent above the pristine values. The silicone samples with the greater AO exposure (7.75 10(exp 21) atoms/sq cm and higher) appear to have a surface layer which contains SiO2 with perhaps small amounts of unreacted silicone, CO and CO2 sealed inside.