AlGaN-Cladding-Free m-Plane InGaN/GaN Laser Diodes with p-Type AlGaN Etch Stop Layers

NASA Astrophysics Data System (ADS)

Farrell, Robert M.; Haeger, Daniel A.; Hsu, Po Shan; Hardy, Matthew T.; Kelchner, Kathryn M.; Fujito, Kenji; Feezell, Daniel F.; Mishra, Umesh K.; DenBaars, Steven P.; Speck, James S.; Nakamura, Shuji

2011-09-01

We present a new method of improving the accuracy and reproducibility of dry etching processes for ridge waveguide InGaN/GaN laser diodes (LDs). A GaN:Al0.09Ga0.91N etch rate selectivity of 11:1 was demonstrated for an m-plane LD with a 40 nm p-Al0.09Ga0.91N etch stop layer (ESL) surrounded by Al-free cladding layers, establishing the effectiveness of AlGaN-based ESLs for controlling etch depth in ridge waveguide InGaN/GaN LDs. These results demonstrate the potential for integrating AlGaN ESLs into commercial device designs where accurate control of the etch depth of the ridge waveguide is necessary for stable, kink-free operation at high output powers.

High-voltage 4H-SiC trench MOS barrier Schottky rectifier with low forward voltage drop using enhanced sidewall layer

NASA Astrophysics Data System (ADS)

Cho, Doohyung; Sim, Seulgi; Park, Kunsik; Won, Jongil; Kim, Sanggi; Kim, Kwangsoo

2015-12-01

In this paper, a 4H-SiC trench MOS barrier Schottky (TMBS) rectifier with an enhanced sidewall layer (ESL) is proposed. The proposed structure has a high doping concentration at the trench sidewall. This high doping concentration improves both the reverse blocking and forward characteristics of the structure. The ESL-TMBS rectifier has a 7.4% lower forward voltage drop and a 24% higher breakdown voltage. However, this structure has a reverse leakage current that is approximately three times higher than that of a conventional TMBS rectifier owing to the reduction in energy barrier height. This problem is solved when ESL is used partially, since its use provides a reverse leakage current that is comparable to that of a conventional TMBS rectifier. Thus, the forward voltage drop and breakdown voltage improve without any loss in static and dynamic characteristics in the ESL-TMBS rectifier compared with the performance of a conventional TMBS rectifier.

Reducing Hysteresis and Enhancing Performance of Perovskite Solar Cells Using Low-Temperature Processed Y-Doped SnO2 Nanosheets as Electron Selective Layers.

PubMed

Yang, Guang; Lei, Hongwei; Tao, Hong; Zheng, Xiaolu; Ma, Junjie; Liu, Qin; Ke, Weijun; Chen, Zhiliang; Xiong, Liangbin; Qin, Pingli; Chen, Zhao; Qin, Minchao; Lu, Xinhui; Yan, Yanfa; Fang, Guojia

2017-01-01

Despite the rapid increase of efficiency, perovskite solar cells (PSCs) still face some challenges, one of which is the current-voltage hysteresis. Herein, it is reported that yttrium-doped tin dioxide (Y-SnO 2 ) electron selective layer (ESL) synthesized by an in situ hydrothermal growth process at 95 °C can significantly reduce the hysteresis and improve the performance of PSCs. Comparison studies reveal two main effects of Y doping of SnO 2 ESLs: (1) it promotes the formation of well-aligned and more homogeneous distribution of SnO 2 nanosheet arrays (NSAs), which allows better perovskite infiltration, better contacts of perovskite with SnO 2 nanosheets, and improves electron transfer from perovskite to ESL; (2) it enlarges the band gap and upshifts the band energy levels, resulting in better energy level alignment with perovskite and reduced charge recombination at NSA/perovskite interfaces. As a result, PSCs using Y-SnO 2 NSA ESLs exhibit much less hysteresis and better performance compared with the cells using pristine SnO 2 NSA ESLs. The champion cell using Y-SnO 2 NSA ESL achieves a photovoltaic conversion efficiency of 17.29% (16.97%) when measured under reverse (forward) voltage scanning and a steady-state efficiency of 16.25%. The results suggest that low-temperature hydrothermal-synthesized Y-SnO 2 NSA is a promising ESL for fabricating efficient and hysteresis-less PSC. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Assessment of Surface Ship Maintenance Requirements

DTIC Science & Technology

2015-01-01

specifically Operational Availability (Ao) and Expected Service Life ( ESL ). Second, it requested NDRI to develop a maintenance requirement concept for each...ship class that supports ESL but allows for some risk within the maintenance strategy. It also asked researchers to define the risks to Ao and ESL ...to minimize negative effects to Ao and ESL and maintain the largest, most capable fleet possible. Note that the tasking did not request a complete

Investigation on the Use of Equivalency Factors for the Design and Evaluation of Flexible Airfield Pavements

DTIC Science & Technology

2014-03-27

Operations on Alternate Launch and Recovery Surfaces (No. ESL -TR-83-46). Tyndall Air Force Base, FL: Air Force Engineering and Services Center. U.S...Little, D. N., Thompson, M. R., Terrell, R. L., Epps, J. A., & Barenberg, E. J. (1987). Soil Stabilization for Roadways and Airfields (No. ESL -TR...Alternate Launch and Recovery Surfaces (No. ESL -TR-83-46). Tyndall Air Force Base, FL: Air Force Engineering and Services Center. U.S. Army Corps of

Thermophysical Property Measurements in the MSFC ESL

NASA Technical Reports Server (NTRS)

Hyers, R. W.; Rogers, J. R.; Robinson, M. B.; Rathz, T. J.; Curreri, Peter A. (Technical Monitor)

2002-01-01

Electrostatic Levitation (ESL) is an advanced technique for containerless processing of metals, ceramics, and semiconductors. Because no container is required, there is no contamination from reaction with a crucible, allowing processing of high temperature, highly reactive melts. The high vacuum processing environment further reduces possible contamination of the samples. Finally, there is no container to provide heterogeneous nucleation sites, so the undercooled range is also accessible for many materials. For these reasons, ESL provides a unique environment for measuring thermophysical properties of liquid materials. The properties that can be measured in ESL include density, surface tension, viscosity, electrical and thermal conductivity, specific heat, phase diagram, TTT- and CCT- curves, and other thermodynamic properties. In this paper, we present data on surface tension and viscosity, measured by the oscillating drop technique, and density, measured by an automated photographic technique, measured in the ESL at NASA Marshall Space Flight Center.

Enhancing Performance and Uniformity of Perovskite Solar Cells via a Solution-Processed C70 Interlayer for Interface Engineering.

PubMed

Zhou, Ya-Qing; Wu, Bao-Shan; Lin, Guan-Hua; Li, Yang; Chen, Di-Chun; Zhang, Peng; Yu, Ming-Yu; Zhang, Bin-Bin; Yun, Da-Qin

2017-10-04

Although some kinds of semiconductor metal oxides (SMOs) have been applied as electron selective layers (ESLs) for planar perovskite solar cells (PSCs), electron transfer is still limited by low electron mobility and defect film formation of SMO ESLs fabricated via low-temperature solution process. Herein, the C 70 interlayer between TiO 2 and (HC(NH 2 ) 2 PbI 3 ) x (CH 3 NH 3 PbCl 3 ) 1-x is prepared by spin-coating and low-temperature annealing for planar n-i-p PSCs. The resultant TiO 2 /C 70 ESL shows good surface morphology, efficient electron extraction, and facilitation of high-quality perovskite film formation, which can be attributed to the suitable nanosize and the superior electronic property of C 70 molecules. In comparison with pristine TiO 2 -based PSCs, the efficiency and hysteresis index are, respectively, enhanced 28% and reduced 76% by adding the C 70 interlayer between TiO 2 and perovskite on the basis of statistical data of more than 50 cells. With the main advantages of low-temperature process and optimized interface, the champion efficiency of PSCs on flexible substrates could exceed 12% in contrast with the above 18% on rigid substrate.

1.3-μm InGaAsP planar buried heterostructure laser diodes with AlInAs electron stopper layer

NASA Astrophysics Data System (ADS)

Tsai, Chia-Lung; Yen, Chih-Ta; Chou, Cheng-Yi; Chang, S. J.; Wu, Meng-Chyi

2012-06-01

This study reports on the realization of 1.3-μm InGaAsP buried-heterostructure (BH) laser diodes (LDs) via an Fe-doped semi-insulating InP layer and an AlInAs electron stopper layer (ESL). Experimentally, the as-cleaved BH LD with an AlInAs ESL exhibited improved characteristics in terms of threshold current, slope efficiency, and maximum light output power at 90 °C as compared to those of the normal BH LD without an AlInAs ESL. In addition, high internal quantum efficiency or reduced threshold current density was observed, indicating increased modal gain in BH LDs fabricated with an AlInAs epilayer on top of the active region. It was also found that the temperature sensitivity of the BH LDs with an AlInAs ESL is more stable than that of the normal BH LDs. These results could be attributed to the suppression of thermal carrier leakage out of strain-compensated multiple-quantum-well by a large conduction-band offset of the AlInAs/InGaAsP heterojunction. Otherwise, without consideration of damping factor or coupling loss, the 3-dB bandwidth of the proposed BH LDs reaches a high value of 15.3 GHz. Finally, this TO-can packaged BH LD shows an eye-opening feature with the extinction ratio of 7.49 dB while operating at 10 Gbit/s at 50 mA.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Chen; Metzler, Dominik; Oehrlein, Gottlieb S., E-mail: oehrlein@umd.edu

Angstrom-level plasma etching precision is required for semiconductor manufacturing of sub-10 nm critical dimension features. Atomic layer etching (ALE), achieved by a series of self-limited cycles, can precisely control etching depths by limiting the amount of chemical reactant available at the surface. Recently, SiO{sub 2} ALE has been achieved by deposition of a thin (several Angstroms) reactive fluorocarbon (FC) layer on the material surface using controlled FC precursor flow and subsequent low energy Ar{sup +} ion bombardment in a cyclic fashion. Low energy ion bombardment is used to remove the FC layer along with a limited amount of SiO{sub 2} frommore » the surface. In the present article, the authors describe controlled etching of Si{sub 3}N{sub 4} and SiO{sub 2} layers of one to several Angstroms using this cyclic ALE approach. Si{sub 3}N{sub 4} etching and etching selectivity of SiO{sub 2} over Si{sub 3}N{sub 4} were studied and evaluated with regard to the dependence on maximum ion energy, etching step length (ESL), FC surface coverage, and precursor selection. Surface chemistries of Si{sub 3}N{sub 4} were investigated by x-ray photoelectron spectroscopy (XPS) after vacuum transfer at each stage of the ALE process. Since Si{sub 3}N{sub 4} has a lower physical sputtering energy threshold than SiO{sub 2}, Si{sub 3}N{sub 4} physical sputtering can take place after removal of chemical etchant at the end of each cycle for relatively high ion energies. Si{sub 3}N{sub 4} to SiO{sub 2} ALE etching selectivity was observed for these FC depleted conditions. By optimization of the ALE process parameters, e.g., low ion energies, short ESLs, and/or high FC film deposition per cycle, highly selective SiO{sub 2} to Si{sub 3}N{sub 4} etching can be achieved for FC accumulation conditions, where FC can be selectively accumulated on Si{sub 3}N{sub 4} surfaces. This highly selective etching is explained by a lower carbon consumption of Si{sub 3}N{sub 4} as compared to SiO{sub 2}. The comparison of C{sub 4}F{sub 8} and CHF{sub 3} only showed a difference in etching selectivity for FC depleted conditions. For FC accumulation conditions, precursor chemistry has a weak impact on etching selectivity. Surface chemistry analysis shows that surface fluorination and FC reduction take place during a single ALE cycle for FC depleted conditions. A fluorine rich carbon layer was observed on the Si{sub 3}N{sub 4} surface after ALE processes for which FC accumulation takes place. The angle resolved-XPS thickness calculations confirmed the results of the ellipsometry measurements in all cases.« less

Extended Schmidt law holds for faint dwarf irregular galaxies

NASA Astrophysics Data System (ADS)

Roychowdhury, Sambit; Chengalur, Jayaram N.; Shi, Yong

2017-12-01

Context. The extended Schmidt law (ESL) is a variant of the Schmidt which relates the surface densities of gas and star formation, with the surface density of stellar mass added as an extra parameter. Although ESL has been shown to be valid for a wide range of galaxy properties, its validity in low-metallicity galaxies has not been comprehensively tested. This is important because metallicity affects the crucial atomic-to-molecular transition step in the process of conversion of gas to stars. Aims: We empirically investigate for the first time whether low metallicity faint dwarf irregular galaxies (dIrrs) from the local universe follow the ESL. Here we consider the "global" law where surface densities are averaged over the galactic discs. dIrrs are unique not only because they are at the lowest end of mass and star formation scales for galaxies, but also because they are metal-poor compared to the general population of galaxies. Methods: Our sample is drawn from the Faint Irregular Galaxy GMRT Survey (FIGGS) which is the largest survey of atomic hydrogen in such galaxies. The gas surface densities are determined using their atomic hydrogen content. The star formation rates are calculated using GALEX far ultraviolet fluxes after correcting for dust extinction, whereas the stellar surface densities are calculated using Spitzer 3.6 μm fluxes. The surface densities are calculated over the stellar discs defined by the 3.6 μm images. Results: We find dIrrs indeed follow the ESL. The mean deviation of the FIGGS galaxies from the relation is 0.01 dex, with a scatter around the relation of less than half that seen in the original relation. In comparison, we also show that the FIGGS galaxies are much more deviant when compared to the "canonical" Kennicutt-Schmidt relation. Conclusions: Our results help strengthen the universality of the ESL, especially for galaxies with low metallicities. We suggest that models of star formation in which feedback from previous generations of stars set the pressure in the interstellar medium and affect ongoing star formation, are promising candidates for explaining the ESL. We also confirm that ESL is an independent relation and not a form of a relation between star formation efficiency and metallicity.

From Red Cells to Soft Porous Lubrication

NASA Astrophysics Data System (ADS)

Wu, Qianhong; Gacka, Thomas; Nathan, Rungun; Crawford, Robert; Vucbmss Team

2014-11-01

Biological scientists have wondered, since the motion of red cells was first observed in capillaries, how the highly flexible red cell can move with so little friction in tightly fitting microvessels without being damaged or undergoing hemolysis. Theoretical studies (Feng and Weinbaum, 2000, JFM; Wu et al., 2004, PRL) attributed this frictionless motion to the dramatically enhanced hydrodynamic lifting force generated inside the soft, porous, endothelial surface layer (ESL) covering the inner surfaces of our capillaries, as a red blood cell glides over it. Herein we report the first experimental examination of this concept. The results conclusively demonstrate that significant fraction of the overall lifting force generated in a soft porous layer as a planing surface glides over it, is contributed by the pore fluid pressure, and thus frictional loss is reduced significantly. Moreover, the experimental predictions showed excellent agreement with the experimental data. This finding has the potential of dramatically changing existing lubrication approaches, and can result in substantial savings in energy consumption and thus reduction in greenhouse gas emissions.

Geospatial assessment of bioenergy land use and its impacts on soil erosion in the U.S. Midwest.

PubMed

SooHoo, William M; Wang, Cuizhen; Li, Huixuan

2017-04-01

Agricultural land use change, especially corn expansion since 2000s, has been accelerating to meet the growing bioenergy demand of the United States. This study identifies the environmentally sensitive lands (ESLs) in the U.S. Midwest using the distance-weighted Revised Universal Soil Loss Equation (RUSLE) associated with bioenergy land uses extracted from USDA Cropland Data Layers. The impacts of soil erosion to downstream wetlands and waterbodies in the river basin are counted in the RUSLE with an inverse distance weighting approach. In a GIS-ranking model, the ESLs in 2008 and 2011 (two representative years of corn expansion) are ranked based on their soil erosion severity in crop fields. Under scenarios of bioenergy land use change (corn to grass and grass to corn) on two land types (ESLs and non-ESLs) at three magnitudes (5%, 10% and 15% change), this study assesses the potential environmental impacts of bioenergy land use at a basin level. The ESL distributions and projected trends vary geographically responding to different agricultural conversions. Results support the idea of re-planting native prairie grasses in the identified High and Severe rank ESLs for sustainable bioenergy management in this important agricultural region. Copyright © 2016 Elsevier Ltd. All rights reserved.

Investigation of an anomalous hump phenomenon in via-type amorphous In-Ga-Zn-O thin-film transistors under positive bias temperature stress

NASA Astrophysics Data System (ADS)

Yang, Jianwen; Liao, Po-Yung; Chang, Ting-Chang; Chen, Bo-Wei; Huang, Hui-Chun; Su, Wan-Ching; Chiang, Hsiao-Cheng; Zhang, Qun

2017-04-01

Amorphous InGaZnO thin film transistors (a-IGZO TFTs) with an etching-stop layer (ESL) exhibit an anomalous negative shift of threshold voltage (Vth) under positive bias temperature stress. TFTs with wider and shorter channels show a clear hump phenomenon, resulting from the existence of both main channels and parasitic channels. The electrons trapped in the gate insulator are responsible for the positive shift in the main channel characteristics. The electrons trapped near the IGZO edges and the holes injected into the ESL layer above InGaZnO (IGZO) jointly determine the shift of the parasitic TFT performance.

Cooperative tin oxide fullerene electron selective layers for high-performance planar perovskite solar cells

DOE PAGES

Ke, Weijun; Zhao, Dewei; Xiao, Chuanxiao; ...

2016-08-17

Both tin oxide (SnO 2) and fullerenes have been reported as electron selective layers (ESLs) for producing efficient lead halide perovskite solar cells. Here, we report that SnO 2 and fullerenes can work cooperatively to further boost the performance of perovskite solar cells. We find that fullerenes can be redissolved during perovskite deposition, allowing ultra-thin fullerenes to be retained at the interface and some dissolved fullerenes infiltrate into perovskite grain boundaries. The SnO 2 layer blocks holes effectively; whereas, the fullerenes promote electron transfer and passivate both the SnO 2/perovskite interface and perovskite grain boundaries. With careful device optimization, themore » best-performing planar perovskite solar cell using a fullerene passivated SnO 2 ESL has achieved a steady-state efficiency of 17.75% and a power conversion efficiency of 19.12% with an open circuit voltage of 1.12 V, a short-circuit current density of 22.61 mA cm -2, and a fill factor of 75.8% when measured under reverse voltage scanning. In conclusion, we find that the partial dissolving of fullerenes during perovskite deposition is the key for fabricating high-performance perovskite solar cells based on metal oxide/fullerene ESLs.« less

Properties of liquid Ti alloys from electrostatic levitation experiments and simulation

NASA Astrophysics Data System (ADS)

Novak, Brian; Raush, Jonathan; Zhang, Xiaoman; Moldovan, Dorel; Meng, Wenjin; Guo, Shengmin

Accurate thermophysical property data for liquid metals and alloys are important for the development of realistic simulations of laser-based 3D printing processes. We are using the container-less electrostatic levitation (ESL) method, molecular simulation, and CALPHAD calculations to obtain such data for Ti alloys. We performed vacuum ESL measurements of viscosity and surface tension with an oscillating drop technique at NASA MSFC on molten elemental Ti, Ti-xAl binaries (x = 0-10 wt%), Ti-6Al-4V, and Ti-6Al-4V-10Mo which showed improved mechanical properties compared with traditional β Ti alloys. We also used classical molecular simulations to obtain viscosities and surface tensions for Ti-xAl. Pair distribution functions, diffusivities, and vapor pressures were also obtained from simulations. The simulated viscosities and surface tensions for pure Ti agree well with the ESL data while the Ti-xAl viscosities have the same trends as the ESL data, but not quantitative agreement. Chemical activity and Gibbs free energy of Ti-10Al were generated using the CALPHAD technique and compared to experimental values. Supported by the National Science Foundation through cooperative agreement OIA-1541079 and the Louisiana Board of Regents.

Electrostatic Levitation for Studies of Additive Manufactured Materials

NASA Technical Reports Server (NTRS)

SanSoucie, Michael P.; Rogers, Jan R.; Tramel, Terri

2014-01-01

The electrostatic levitation (ESL) laboratory at NASA's Marshall Space Flight Center is a unique facility for investigators studying high temperature materials. The laboratory boasts two levitators in which samples can be levitated, heated, melted, undercooled, and resolidified. Electrostatic levitation minimizes gravitational effects and allows materials to be studied without contact with a container or instrumentation. The lab also has a high temperature emissivity measurement system, which provides normal spectral and normal total emissivity measurements at use temperature. The ESL lab has been instrumental in many pioneering materials investigations of thermophysical properties, e.g., creep measurements, solidification, triggered nucleation, and emissivity at high temperatures. Research in the ESL lab has already led to the development of advanced high temperature materials for aerospace applications, coatings for rocket nozzles, improved medical and industrial optics, metallic glasses, ablatives for reentry vehicles, and materials with memory. Modeling of additive manufacturing materials processing is necessary for the study of their resulting materials properties. In addition, the modeling of the selective laser melting processes and its materials property predictions are also underway. Unfortunately, there is very little data for the properties of these materials, especially of the materials in the liquid state. Some method to measure thermophysical properties of additive manufacturing materials is necessary. The ESL lab is ideal for these studies. The lab can provide surface tension and viscosity of molten materials, density measurements, emissivity measurements, and even creep strength measurements. The ESL lab can also determine melting temperature, surface temperatures, and phase transition temperatures of additive manufactured materials. This presentation will provide background on the ESL lab and its capabilities, provide an approach to using the ESL in supporting the development and modeling of the selective laser melting process for metals, and provide an overview of the results to date.

Floating the Ball: Advances in the Technology of Electrostatic Levitation

NASA Technical Reports Server (NTRS)

Rogers, Jan R.

2006-01-01

Electrostatic Levitation (ESL) is an emerging technology. The MSFC ESL is a NASA facility that supports investigations of refractory solids and melts. The facility can be used to process a wide variety of materials including metals, alloys, ceramics, glasses and semiconductors. Containerless processing via ESL provides a high-purity environment for the study of high temperature materials and access to metastable states. Scientific topics investigated in the facility include nucleation, undercooling, metastable state formation and metallic glass formation. Additionally, the MSFC ESL provides data for the determination of phase diagrams, time-temperature-transition diagrams, viscosity, surface tension, density, heat capacity and creep resistance. In order to support a diverse research community, the MSFC ESL facility has developed a number of technical capabilities, including a portable system for in situ studies of structural tran$hrmations during processing at the high-energy X-ray beamline at the Advanced Photon Source of Argonne National Laboratory. The capabilities of the MSFC ESL facilities will be discussed and selected results of materials processing and characterization studies will be presented.

Observations and consequences of nonuniform aluminum concentrations in the channel regions of AlGaAs channeled-substrate-planar lasers

NASA Technical Reports Server (NTRS)

Evans, Gary A.; Goldstein, Bernard; Butler, Jerome K.

1987-01-01

Compositional changes in the n-clad layer within the channel region of channel substrate planar (CSP) type semiconductor lasers have been observed. As a consequece, a large optical cavity (LOC) or an enhanced substrate loss (ESL) version of the CSP geometry may result, both of which may have significantly different characteristics from those of a conventional CSP laser. The CSP-LOC generally has a larger near-field spot size, while the ESL-CSP is characterized by an off-axis, asymmetric far-field pattern.

Initial Investigation of a Novel Thermal Storage Concept as Part of a Renewable Energy System

DTIC Science & Technology

2013-06-01

stress (pascal) z-component of shear stress (pascal) Fslip constant Esl ip constant surface tension gradient (n/m-k) specularity coefficient...Axis x-component of ¥-Component of z- component of x -component of v-component of z-component of Fs l ip constant Esl i p constant Rotation

Factors Influencing Social, Cultural, and Academic Transitions of Chinese International ESL Students in U.S. Higher Education

ERIC Educational Resources Information Center

Ota, Akiko

2013-01-01

The U.S. is the leading nation for international students to pursue higher education; the majority of whom are from countries with significant differences in culture and language from American students. As such, many international students start higher education in ESL support programs. While on the surface international students supposedly add…

An efficient finite element with layerwise mechanics for smart piezoelectric composite and sandwich shallow shells

NASA Astrophysics Data System (ADS)

Yasin, M. Yaqoob; Kapuria, S.

2014-01-01

In this work, we present a new efficient four-node finite element for shallow multilayered piezoelectric shells, considering layerwise mechanics and electromechanical coupling. The laminate mechanics is based on the zigzag theory that has only seven kinematic degrees of freedom per node. The normal deformation of the piezoelectric layers under the electric field is accounted for without introducing any additional deflection variables. A consistent quadratic variation of the electric potential across the piezoelectric layers with the provision of satisfying the equipotential condition of electroded surfaces is adopted. The performance of the new element is demonstrated for the static response under mechanical and electric potential loads, and for free vibration response of smart shells under different boundary conditions. The predictions are found to be very close to the three dimensional piezoelasticity solutions for hybrid shells made of not only single-material composite substrates, but also sandwich substrates with a soft core for which the equivalent single layer (ESL) theories perform very badly.

Evaluation of stress stabilities in amorphous In-Ga-Zn-O thin-film transistors: Effect of passivation with Si-based resin

NASA Astrophysics Data System (ADS)

Ochi, Mototaka; Hino, Aya; Goto, Hiroshi; Hayashi, Kazushi; Fujii, Mami N.; Uraoka, Yukiharu; Kugimiya, Toshihiro

2018-02-01

Fabrication process conditions of a passivation (PV) layer correlated with stress stabilities of amorphous In-Ga-Zn-O (a-IGZO) thin-film transistors (TFTs). In etch-stop layer (ESL)-TFTs, by inserting a Si-based resin between SiN x and SiO x PV layers, the peak intensity in the photoinduced transient spectroscopy (PITS) spectrum was notably reduced. This suggested the suppression of hydrogen incorporation into a-IGZO, which led to the improvement of stability under negative bias thermal illumination stress (NBTIS). In contrast, the hydrogen-related defects in the a-IGZO were easily formed by the back-channel etch (BCE) process. Furthermore, it was found that, under NBTIS, the transfer curves of the BCE-TFTs shifted in parallel owing to the positive fixed charge located in the back channel of the a-IGZO TFTs. The hump-shaped shift increased with stress time. This is because hydrogen atoms located at the back-channel surfaces of the a-IGZO and/or PV layers were incorporated into the channel region of the BCE-TFTs and induced the hydrogen-related defects.

INTERIM REPORT--INDEPENDENT VERIFICATION SURVEY OF SECTION 3, SURVEY UNITS 1, 4 AND 5 EXCAVATED SURFACES, WHITTAKER CORPORATION, REYNOLDS INDUSTRIAL PARK, TRANSFER, PENNSYLVANIA DCN: 5002-SR-04-0"

DOE Office of Scientific and Technical Information (OSTI.GOV)

ADAMS, WADE C

At Pennsylvania Department of Environmental Protection's request, ORAU's IEAV program conducted verification surveys on the excavated surfaces of Section 3, SUs 1, 4, and 5 at the Whittaker site on March 13 and 14, 2013. The survey activities included visual inspections, gamma radiation surface scans, gamma activity measurements, and soil sampling activities. Verification activities also included the review and assessment of the licensee's project documentation and methodologies. Surface scans identified four areas of elevated direct gamma radiation distinguishable from background; one area within SUs 1 and 4 and two areas within SU5. One area within SU5 was remediated by removingmore » a golf ball size piece of slag while ORAU staff was onsite. With the exception of the golf ball size piece of slag within SU5, a review of the ESL Section 3 EXS data packages for SUs 1, 4, and 5 indicated that these locations of elevated gamma radiation were also identified by the ESL gamma scans and that ESL personnel performed additional investigations and soil sampling within these areas. The investigative results indicated that the areas met the release criteria.« less

Surface oscillation of levitated liquid droplets under microgravity

NASA Astrophysics Data System (ADS)

Watanabe, Masahito; Hibiya, Taketoshi; Ozawa, Shumpei; Mizuno, Akitoshi

2012-07-01

Microgravity conditions have advantages of measurement of surface tension and viscosity of metallic liquids by the oscillating drop method with an electromagnetic levitation (EML) device. Thus, we are now planning the thermophysical properties, the surface tension, viscosity, density and etc., measurements of liquid alloys using the electromagnetic levitator named MSL-EML (Materials Science Laboratory Electromagnetic Levitator), which ahs been developed by the European Space Agency (ESA), installed in the International Space Station (ISS). The surface tension and the viscosity of liquid samples by the oscillating drop method are obtained from the surface oscillation frequency and damping time of surface oscillation respectively. However, analysis of oscillating drop method in EML must be improved even in the microgravity conditions, because on the EML conditions the electromagnetic force (EMF) cannot generate the surface oscillation with discretely oscillation mode. Since under microgravity the levitated droplet shape is completely spherical, the surface oscillation frequency with different oscillation modes degenerates into the single frequency. Therefore, surface tension will be not affected the EML condition under microgravity, but viscosity will be affected on the different oscillation mode of surface oscillations. Because dumping time of surface oscillation of liquid droplets depends on the oscillation modes, the case of surface oscillation including multi oscillation modes the viscosity values obtained from dumping time will be modified from the correct viscosity. Therefore, we investigate the dumping time of surface oscillation of levitated droplets with different oscillation modes and also with including multi oscillation modes using the electrostatic levitation (ESL) on ground and EML under microgravity conditions by the parabolic flight of airplane. The ESL can discretely generate the surface oscillation with different oscillation modes by the change of generation frequency of surface oscillation, so we can obtain dumping time of surface oscillation with discrete oscillation mode. We repot the results of the damping time of the surface oscillation of levitated liquid droplet by ESL and EML experiment with numerical simulation of the damped oscillation model.

Edge Simulation Laboratory Progress and Plans

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohen, R

The Edge Simulation Laboratory (ESL) is a project to develop a gyrokinetic code for MFE edge plasmas based on continuum (Eulerian) techniques. ESL is a base-program activity of OFES, with an allied algorithm research activity funded by the OASCR base math program. ESL OFES funds directly support about 0.8 FTE of career staff at LLNL, a postdoc and a small fraction of an FTE at GA, and a graduate student at UCSD. In addition the allied OASCR program funds about 1/2 FTE each in the computations directorates at LBNL and LLNL. OFES ESL funding for LLNL and UCSD began inmore » fall 2005, while funding for GA and the math team began about a year ago. ESL's continuum approach is a complement to the PIC-based methods of the CPES Project, and was selected (1) because of concerns about noise issues associated with PIC in the high-density-contrast environment of the edge pedestal, (2) to be able to exploit advanced numerical methods developed for fluid codes, and (3) to build upon the successes of core continuum gyrokinetic codes such as GYRO, GS2 and GENE. The ESL project presently has three components: TEMPEST, a full-f, full-geometry (single-null divertor, or arbitrary-shape closed flux surfaces) code in E, {mu} (energy, magnetic-moment) coordinates; EGK, a simple-geometry rapid-prototype code, presently of; and the math component, which is developing and implementing algorithms for a next-generation code. Progress would be accelerated if we could find funding for a fourth, computer science, component, which would develop software infrastructure, provide user support, and address needs for data handing and analysis. We summarize the status and plans for the three funded activities.« less

The Role of Linguistic Modification in Nursing Education.

PubMed

Moore, Brenda S; Clark, Michele C

2016-06-01

English-as-a-second-language (ESL) nursing students fail to graduate from programs at alarming rates. For many of these students, academic failure results from poor performance on multiple choice examinations, which frequently contain linguistic errors. A remedy for these errors is to linguistically modify examination questions. This study assessed the effects of linguistic modification on examination scores. Scores of ESL and non-ESL nursing students were compared on an experimental multiple choice examination and a control examination. After exclusion, 67 ESL and 252 non-ESL students completed the experimental examination; 68 ESL and 257 non-ESL students completed the control examination. Both ESL and non-ESL students scored higher on the experimental examination than on the control examination. For ESL students, the increase in observed means between the experimental and control examination was 0.6%; for non-ESL students, the increase was 0.48%. [J Nurs Educ. 2016;55(6):309-315.]. Copyright 2016, SLACK Incorporated.

Electrostatic Levitation: A Tool to Support Materials Research in Microgravity

NASA Technical Reports Server (NTRS)

Rogers, Jan; SanSoucie, Mike

2012-01-01

Containerless processing represents an important topic for materials research in microgravity. Levitated specimens are free from contact with a container, which permits studies of deeply undercooled melts, and high-temperature, highly reactive materials. Containerless processing provides data for studies of thermophysical properties, phase equilibria, metastable state formation, microstructure formation, undercooling, and nucleation. The European Space Agency (ESA) and the German Aerospace Center (DLR) jointly developed an electromagnetic levitator facility (MSL-EML) for containerless materials processing in space. The electrostatic levitator (ESL) facility at the Marshall Space Flight Center provides support for the development of containerless processing studies for the ISS. Apparatus and techniques have been developed to use the ESL to provide data for phase diagram determination, creep resistance, emissivity, specific heat, density/thermal expansion, viscosity, surface tension and triggered nucleation of melts. The capabilities and results from selected ESL-based characterization studies performed at NASA's Marshall Space Flight Center will be presented.

From red cells to soft porous lubrication.

NASA Astrophysics Data System (ADS)

Wu, Qianhong; Zhu, Zenghao; Nathan, Rungun

2017-11-01

In this paper, we report a novel experimental study to examine the lubrication theory for highly compressible porous media (Feng & Weinbaum, JFM, 422, 282, 2000), which was applied to the frictionless motion of red cells over the endothelial surface layer (ESL). The experimental setup consists of a running conveyer belt covered with a porous sheet, and an upper planar board, i.e. planing surface. The pore pressure generation was captured when the planing surface glides over the porous sheet. If the lateral leakage was eliminated, we found that the overall pore pressure's contribution to the total lift, fair 80%, and the friction coefficient η = 0.0981, when U =5 m/s, L =0.381 m, λ = h2/h0 = 1 and k =h2/h1 = 3, where U is the velocity of the conveyor belt; L is the planing surface length; h0, h1 and h2 are the undeformed, leading and trailing edge porous layer thickness, respectively. fair increases with the increase in U, λ and L, while decreases with the increase in k. η decreases with the increase in fair. If lateral pressure leakage exists, the pore pressure generation is reduced by nearly 90%. All the results agreed well with the theoretical predictions. The study here lays the foundation for applying soft porous media for new type of bearing with significantly reduced friction. This research was supported by the National Science Foundation (NSF CBET) under Award No. 1511096.

How Do Chinese ESL Learners Recognize English Words during a Reading Test? A Comparison with Romance-Language-Speaking ESL Learners

ERIC Educational Resources Information Center

Li, Hongli; Suen, Hoi K.

2015-01-01

This study examines how Chinese ESL learners recognize English words while responding to a multiple-choice reading test as compared to Romance-language-speaking ESL learners. Four adult Chinese ESL learners and three adult Romance-language-speaking ESL learners participated in a think-aloud study with the Michigan English Language Assessment…

Haploinsufficiency of E-selectin ligand-1 is Associated with Reduced Atherosclerotic Plaque Macrophage Content while Complete Deficiency Leads to Early Embryonic Lethality in Mice

PubMed Central

Luo, Wei; Wang, Hui; Guo, Chiao; Wang, Jintao; Kwak, Jeffrey; Bahrou, Kristina L; Eitzman, Daniel T.

2012-01-01

E-selectin-1 (ESL-1), also known as golgi complex-localized glycoprotein-1 (GLG1), homocysteine-rich fibroblast growth factor receptor (CGR-1), and latent transforming growth factor-β complex protein 1 (LTCP-1), is a multifunctional protein with widespread tissue distribution. To determine the functional consequences of ESL-1 deficiency, mice were generated carrying an ESL-1 gene trap. After backcrossing to C57BL6/J for 6 generations, mice heterozygous for the gene trap (ESL-1+/-) were intercrossed to produce ESL-1-/- mice, however ESL-1-/- mice were not viable, even at embryonic day E10.5. To determine the effect of heterozygous ESL-1 deficiency on atherosclerosis, apolipoprotein E deficient (ApoE-/-), ESL-1+/- mice were generated and fed western diet. Compared to ApoE-/-, ESL-1++ mice, atherosclerotic lesions from ApoE-/-, ESL-1+/- contained more collagen and fewer macrophages, suggesting increased plaque stability. In conclusion, heterozygous deficiency of ESL-1 is associated with features of increased atherosclerotic plaque stability while complete deficiency of ESL-1 leads to embryonic lethality. PMID:22939356

Correlation of trap states with negative bias thermal illumination stress stabilities in amorphous In-Ga-Zn-O thin-film transistors studied by photoinduced transient spectroscopy

NASA Astrophysics Data System (ADS)

Hayashi, Kazushi; Ochi, Mototaka; Hino, Aya; Tao, Hiroaki; Goto, Hiroshi; Kugimiya, Toshihiro

2017-03-01

Negative bias thermal illumination stress (NBTIS) stabilities in amorphous In-Ga-Zn-O (a-IGZO) thin-film transistors (TFTs) were studied by photoinduced transient spectroscopy (PITS). The degradation of TFT performance correlated with trap states in the channel region of a-IGZO TFTs with an etch stop layer (ESL). A prominent peak at approximately 100 K was observed in a-IGZO formed under a partial pressure (p/p) of 4% O2. With increasing O2 p/p, an apparent shoulder of around 230 K appeared in PITS spectra. A higher flow rate of SiH4/N2O for the ESL deposition induced trap states associated with the 230 K peak. The peak at approximately 100 K could originate from the depletion of Zn by preannealing, while the peak at approximately 230 K should be attributed to the oxygen-deficient and/or Zn-rich defects due to the formation of OH in a-IGZO. The trap states in a-IGZO TFTs gave rise to degradation in terms of NBTIS. The threshold voltage shift (ΔV th) was 2.5 V, but it increased with the O2 p/p as well as the flow rate of SiH4/N2O for ESL deposition. The time dependence of ΔV th suggested that hydrogen from the ESL and/or in the a-IGZO thin films was incorporated and modified the trap states in the channel region of the a-IGZO TFTs.

Developing College English as a Second Language (ESL) Programs

ERIC Educational Resources Information Center

Orlova, Irina A.; Kennedy, Jelane A.

2009-01-01

This article examines available literature on college English as a Second Language (ESL) programs. The literature available on college ESL programs falls into three categories: (1) research reports and articles, (2) recent theoretical discussions on ESL teaching, and (3) thought pieces discussing college ESL curriculum development and assessment…

Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers.

PubMed

Elger, Christian; Bialer, Meir; Falcão, Amílcar; Vaz-da-Silva, Manuel; Nunes, Teresa; Almeida, Luís; Soares-da-Silva, Patrício

2013-08-01

Investigate the pharmacokinetics of once-daily (QD; 900 mg) and twice-daily (BID; 450 mg) regimens of eslicarbazepine acetate (ESL) and BID (450 mg) regimen of oxcarbazepine (OXC) at steady state in healthy volunteers. Single-center, open-label, randomized, three-way (n = 12) crossover studies in healthy volunteers. Mean eslicarbazepine Cmax,ss (in μm) following ESL QD (87.3) was 33.3% higher (p < 0.05) compared to ESL BID (65.5) and 82.1% higher (p < 0.05) compared to OXC BID (48.0). The mean area under the curve (AUC)ss,0-τ (in μmol h/L) following the last dose of an 8-day repeated dosing was 1156.3, 1117.6, and 968.4 for ESL QD, ESL BID, and OXC BID, respectively. The ratio eslicarbazepine plasma exposure (μmol h/L) to ESL daily-dose (μmol) was 0.381 (1156.3:3037.3), 0.368 (1117.6:3037.3), and 0.271 (968.4:3567.6) for ESL-QD, ESL-BID, and OXC-BID, respectively, which translates into a 40.6% increase in the ability of ESL-QD compared to OXC-BID to deliver into the plasma their major active entity eslicarbazepine. The extent of plasma exposure to ESL minor metabolites: (R)-licarbazepine and oxcarbazepine after ESL-QD was 71.5% and 61.1% lower, respectively, than after OXC-BID. Twenty, 24 and 38 treatment emergent adverse events were reported with ESL-QD, ESL-BID, and OXC-BID, respectively. ESL-QD resulted in 33.3% higher peak plasma concentration (Cmax,ss ) of eslicarbazepine and similar extent of plasma exposure (AUCss,0-τ ) when compared to ESL-BID, which may contribute to the efficacy profile reported with once-daily ESL. In comparison to OXC-BID, administration of ESL-QD resulted in 40.6% increase in the delivery of eslicarbazepine into the plasma as well as a significantly lower systemic exposure to (R)-licarbazepine and oxcarbazepine. Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.

Theatre Voice Training and Technology in Teaching Oral Skills: Integrating the Components of a Speech Event

ERIC Educational Resources Information Center

Hardison, Debra M.; Sonchaeng, Chayawan

2005-01-01

This paper provides a sequence of specific techniques and examples for implementing theatre voice training and technology in teaching ESL/EFL oral skills. A layered approach is proposed based on information processing theory in which the focus of learner attention is shifted in stages from the physiological to the linguistic and then to the…

Can eustatic charts go beyond first-order? Insights from the Permo-Triassic

NASA Astrophysics Data System (ADS)

Guillaume, Benjamin; Monteux, Julien; Pochat, Stéphane; Husson, Laurent; Choblet, Gaël

2016-04-01

To the first order, eustatic charts are in accord with our understanding of the geodynamic processes that control sea level. By extrapolation, second-order features are also thought to obey to the same rules, and are thus often taken for granted. But this assumption may be jeopardized by a close examination of a characteristic example. The Permo-Triassic period is characteristic for both its purported eustatic signal and its geodynamic and climatic setting are well defined and contrasted. Both the fragmentation of the Pangean supercontinent and the late Paleozoic melting of ice sheets argue for a rise of the eustatic sea level (ESL) whereas eustatic charts show the opposite. Here we review the possible mechanisms that could explain the apparent sea level low, and find that some of them do lower the ESL while others instead only modify the referential, either uplifting continents or tilting the margins where the control points are located. In the first category, we find that (i) dynamic deflections of the Earth surface above subduction zones and their location with respect to continents primarily control absolute sea level while the Pangean supercontinent forms and breaks up, (ii) endorheism that ubiquitously developed at the time of Pangean aggregation also contributed to lowering the ESL by storing water out of the oceanic reservoir. In the second category, we show that (i) the thermal uplift associated to supercontinental insulation and (ii) the dynamic uplift associated with the emplacement of a superplume both give rates of change in the range of long-term changes of ESL. We also show that (iii) the dynamic tilting of continental margins not only produces apparent sea level changes, but also modifies the absolute sea level, which in turn may end up in the paradoxical situation wherein fingerprints of ESL drop are found in the geological record whereas ESL is actually rising. We conclude that the establishment of second to third order absolute sea level changes may stay for a while a chimera.

Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral contraceptive in healthy women.

PubMed

Falcão, Amilcar; Vaz-da-Silva, Manuel; Gama, Helena; Nunes, Teresa; Almeida, Luís; Soares-da-Silva, Patrício

2013-08-01

To investigate the effect of once-daily (QD) eslicarbazepine acetate (ESL) 800 mg and 1,200 mg administration on pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral contraceptive (OC) in women of childbearing potential. Two two-way, crossover, two-period, randomized, open-label studies were performed in 20 healthy female subjects, each. In one period (ESL+OC period), subjects received ESL 800 mg QD in one study and ESL 1200 mg QD in the other study, for 15 days; concomitantly with the Day 14 ESL dose, an oral single dose of 30 μg ethinylestradiol and 150 μg levonorgestrel was administered. In the other period (OC alone), a single dose of 30 μg ethinylestradiol and 150 μg levonorgestrel was administered. Three weeks or more separated the periods. An analysis of variance (ANOVA) was used to test for differences between pharmacokinetic parameters of 30 μg ethinylestradiol and 150 μg levonorgestrel following ESL+OC and OC alone, and 90% confidence intervals (90%CI) for the ESL+OC/OC alone geometric mean ratio (GMR) were calculated. ESL significantly decreased the systemic exposure to both ethinylestradiol and levonorgestrel. GMR (90%CI) for AUC0-24 of ethinylestradiol were 68% (64%; 71%) following 1,200 mg ESL and 75% (71%; 79%) following 800 mg ESL. GMR (90%CI) for AUC0-24 of levonorgestrel were 76% (68%; 86%) following 1,200 mg ESL and 89% (82%; 97%) following 800 mg ESL. A clinically relevant dose-dependent effect of ESL administration on the pharmacokinetics of ethinylestradiol and levonorgestrel was observed. Therefore, to avoid inadvertent pregnancy, women of childbearing potential should use other adequate methods of contraception during treatment with ESL, and, in case ESL treatment is discontinued, until CYP3A4 activity returns to normal. Copyright © 2013 Elsevier B.V. All rights reserved.

Pedagogical Stances of High School ESL Teachers: "Huelgas" in High School ESL Classrooms

ERIC Educational Resources Information Center

del Carmen Salazar, Maria

2010-01-01

This article presents a qualitative case study of the pedagogical stances of high school English as a Second Language (ESL) teachers, and the subsequent responses of resistance or conformity by their English Language Learners (ELLs). The participants include three high school ESL teachers and 60 high school ESL students of Mexican origin. Findings…

Teachers' Assessment of ESL Students in Mainstream Classes: Challenges, Strategies, and Decision-Making

ERIC Educational Resources Information Center

Cheng, Liying; Milnes, Terry

2008-01-01

Given the increasing numbers of ESL students in Canadian classrooms, this study investigated how teachers of mainstream classes assess the written work of ESL students and whether they use different assessment strategies for ESL versus non-ESL students. Interviews were conducted with seven mainstream teachers from a private high school in Ontario.…

Practical guidance and considerations for transitioning patients from oxcarbazepine or carbamazepine to eslicarbazepine acetate--Expert opinion.

PubMed

Peltola, Jukka; Holtkamp, Martin; Rocamora, Rodrigo; Ryvlin, Philippe; Sieradzan, Kasia; Villanueva, Vicente

2015-09-01

There is currently a lack of guidance on methodology and special considerations for transitioning patients from oxcarbazepine (OXC) or carbamazepine (CBZ) to eslicarbazepine acetate (ESL), if deemed clinically necessary. An advisory panel of epilepsy experts was convened to share their experience on the use of adjunctive ESL in clinical practice and to provide practical recommendations to help address this gap. When changing over from OXC to ESL, an OXC:ESL dose ratio of 1:1 should be employed to calculate the ESL target dose, and the changeover can take place overnight. No changes to comedication are required. Since CBZ has a different mechanism of action to ESL and is a stronger inducer of cytochrome P450 (CYP) enzymes, the transitioning of patients from CBZ to ESL requires careful consideration on a patient-by-patient basis. In general, a CBZ:ESL dose ratio of 1:1.3 should be employed to calculate the ESL target dose, and patients should be transitioned over a minimum period of 1-2weeks. Special considerations include adjustment of titration schedule and target dose in elderly patients and those with hepatic or renal impairment and potential adjustment of comedications metabolized by CYP enzymes. In summary, due to structural distinctions between ESL, OXC, and CBZ, which affect mechanism of action and tolerability, there are clinical situations in which it may be appropriate to consider transitioning patients from OXC or CBZ to ESL. Changing patients over from OXC to ESL is generally more straightforward than transitioning patients from CBZ to ESL, which requires careful consideration. Copyright © 2015 Elsevier Inc. All rights reserved.

The next-generation ESL continuum gyrokinetic edge code

NASA Astrophysics Data System (ADS)

Cohen, R.; Dorr, M.; Hittinger, J.; Rognlien, T.; Collela, P.; Martin, D.

2009-05-01

The Edge Simulation Laboratory (ESL) project is developing continuum-based approaches to kinetic simulation of edge plasmas. A new code is being developed, based on a conservative formulation and fourth-order discretization of full-f gyrokinetic equations in parallel-velocity, magnetic-moment coordinates. The code exploits mapped multiblock grids to deal with the geometric complexities of the edge region, and utilizes a new flux limiter [P. Colella and M.D. Sekora, JCP 227, 7069 (2008)] to suppress unphysical oscillations about discontinuities while maintaining high-order accuracy elsewhere. The code is just becoming operational; we will report initial tests for neoclassical orbit calculations in closed-flux surface and limiter (closed plus open flux surfaces) geometry. It is anticipated that the algorithmic refinements in the new code will address the slow numerical instability that was observed in some long simulations with the existing TEMPEST code. We will also discuss the status and plans for physics enhancements to the new code.

Pacific Fleet Submarine Tender Optimization

DTIC Science & Technology

2013-06-01

worker(s) waits at DG Tender travel (FCB = USS Frank Cable, ESL = USS Emory S. Land) Day 1 FCB waits at GUAM Day 1 ESL ...Day 5 FCB waits at GUAM Day 6 FCB waits at GUAM Day 6 ESL waits at SINGAPORE Day 7 FCB waits...at GUAM Day 7 ESL waits at SINGAPORE Day 8 FCB waits at GUAM Day 8 ESL waits at SINGAPORE Day 9

Reflections on the Pedagogical Imports of Western Practices for Professionalizing ESL/ EFL Writing and Writing-Teacher Education

ERIC Educational Resources Information Center

Zhang, Lawrence Jun

2016-01-01

The teaching of writing in English as a second/foreign language (ESL/EFL) has been a challenging task for many teachers due to its multifaceted nature. This paper is a reflection on ESL/EFL writing teaching in three countries, namely China, Singapore, and New Zealand, with particular reference to professionalizing ESL/ EFL writing and ESL/EFL…

Eslicarbazepine acetate for the treatment of partial epilepsy.

PubMed

Zelano, Johan; Ben-Menachem, Elinor

2016-06-01

Eslicarbazepine acetate (ESL) is a third generation AED structurally related to carbamazepine and oxcarbazepine, but without several of the drawbacks associated with these compounds. ESL is completely metabolized to its eslicarbazpine, which selectively binds inactivated voltage-gated sodium channels and thus selectively reduces the activity of rapidly firing (epileptic) neurons. In addition, ESL has pharmacokinetic properties allowing once daily dosing. This review summarizes data from the initial phase I to III studies, which demonstrated efficacy of ESL as add-on treatment in partial onset epilepsy, and more recent studies that demonstrate efficacy of ESL as monotherapy. Real-life observational studies are also reviewed, and seem to confirm the notion of ESL as a well-tolerated AED. As a new AED, ESL needs to be subject to close monitoring regarding long-term adverse events. Future independent studies will most likely clarify the role of ESL in the management of partial onset seizures. The role of ESL in management of partial onset seizures is discussed, as is the need for close monitoring and evaluation for broad-spectrum pharmacodynamics properties. The characteristics of the molecule and efficacy and safety profiles seem, however, very promising.

Core 1-derived O-glycans are essential E-selectin ligands on neutrophils.

PubMed

Yago, Tadayuki; Fu, Jianxin; McDaniel, J Michael; Miner, Jonathan J; McEver, Rodger P; Xia, Lijun

2010-05-18

Neutrophils roll on E-selectin in inflamed venules through interactions with cell-surface glycoconjugates. The identification of physiologic E-selectin ligands on neutrophils has been elusive. Current evidence suggests that P-selectin glycoprotein ligand-1 (PSGL-1), E-selectin ligand-1 (ESL-1), and CD44 encompass all glycoprotein ligands for E-selectin; that ESL-1 and CD44 use N-glycans to bind to E-selectin; and that neutrophils lacking core 2 O-glycans have partially defective interactions with E-selectin. These data imply that N-glycans on ESL-1 and CD44 and O-glycans on PSGL-1 constitute all E-selectin ligands, with neither glycan subset having a dominant role. The enzyme T-synthase transfers Gal to GalNAcalpha1-Ser/Thr to form the core 1 structure Galbeta1-3GalNAcalpha1-Ser/Thr, a precursor for core 2 and extended core 1 O-glycans that might serve as selectin ligands. Here, using mice lacking T-synthase in endothelial and hematopoietic cells, we found that E-selectin bound to CD44 and ESL-1 in lysates of T-synthase-deficient neutrophils. However, the cells exhibited markedly impaired rolling on E-selectin in vitro and in vivo, failed to activate beta2 integrins while rolling, and did not emigrate into inflamed tissues. These defects were more severe than those of neutrophils lacking PSGL-1, CD44, and the mucin CD43. Our results demonstrate that core 1-derived O-glycans are essential E-selectin ligands; that some of these O-glycans are on protein(s) other than PSGL-1, CD44, and CD43; and that PSGL-1, CD44, and ESL-1 do not constitute all glycoprotein ligands for E-selectin.

Literature review: issues surrounding education of English-as-a-Second Language (ESL) nursing students.

PubMed

Choi, Liza Lai Shan

2005-07-01

Examined in this article are the challenges faced by English-as-a-Second Language (ESL) nursing students. Nursing faculties need to address these challenges to meet the increasing diversity of the health care system. A key concern is the ability of ESL nursing students to communicate effectively in English. The Cummins model for English language acquisition provides a template for ESL nursing students to bridge this communication barrier. The literature suggests some particular needs of ESL nursing students can be met through modification of nursing programs. Further research into factors affecting the quality of nursing education for ESL students is warranted. A quantitative analysis is required to see if there exists a positive correlation between improved English language acquisition and academic success by ESL nursing students.

Exploring Service Logic in ESL

ERIC Educational Resources Information Center

Walker, John

2013-01-01

ESL is both a professional educational service and, particularly in post-compulsory contexts, a commercial activity. The effective management of ESL programs can secure quality outcomes for practitioners and students. Nevertheless, writings on ESL management do not figure prominently in the literature. In particular, the association between…

ESL Magazine: The Information Source for ESL/EFL Professionals, 1998.

ERIC Educational Resources Information Center

ESL Magazine, 1998

1998-01-01

This document consists of the six issues of "ESL Magazine" published during 1998. This journal for English-as-a-Second-Language (ESL) professionals includes the following articles during this period: "The Internet in the Classroom" (Christine Meloni); "Trippingly on the Tongue: Putting Serious, Speech/Pronunciation…

Working toward Literacy in Correctional Education ESL

ERIC Educational Resources Information Center

Gardner, Susanne

2014-01-01

Correctional Education English as a Second Language (ESL) literacy programs vary from state to state, region to region. Some states enroll their correctional ESL students in adult basic education (ABE) classes; other states have separate classes and programs. At the Maryland Correctional Institution in Jessup, the ESL class is a self-contained…

28 CFR 544.41 - Applicability: Who must attend the ESL program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Applicability: Who must attend the ESL... INSTITUTIONAL MANAGEMENT EDUCATION Mandatory English-as-a-Second Language Program (ESL) § 544.41 Applicability: Who must attend the ESL program. (a) All Federal prisoners who have limited English proficiency skills...

An Annotated Bibliography of Adult ESL Instructional Materials.

ERIC Educational Resources Information Center

Escobar, Joanna Sculley; Daugherty, John

This annotated bibliography of adult English as a second language (ESL) student materials, available at the Illinois ESL/Adult Basic Education (ABE) Services Center, was prepared for adult ESL administrators, coordinators, teachers, and teacher aides to provide a representative sampling of materials available and to assist in the selection of…

ESL Parents and Teachers: Towards Dialogue?

ERIC Educational Resources Information Center

Gou, Yan; Mohan, Bernard

2008-01-01

Conflict and miscommunication between English as a Second Language (ESL) parents and teachers has had a major impact on educational policy, but few empirical studies examine it as discourse. This study examines communication between ESL parents and high school ESL teachers in a "Parents' Night" (PN) event organised to increase understanding of the…

ESL Student Bias in Instructional Evaluation.

ERIC Educational Resources Information Center

Wennerstrom, Ann K.; Heiser, Patty

1992-01-01

Reports on a statistical analysis of English-as-a-Second-Language (ESL) student evaluations of teachers in two large programs. Results indicated a systematic bias occurs in ESL student evaluations, raising issues of fairness in the use of student evaluations of ESL teachers for purposes of personnel decisions. (21 references) (GLR)

Listening Instruction and Practice for Advanced ESL Students.

ERIC Educational Resources Information Center

Godfrey, Dennis

This paper attempts to enact Rivers' (1971 and 1972) urgings to base ESL listening instruction on both psychological and linguistic findings and contends that advanced ESL students' listening needs call for improvement in processing spoken English discourse. Psychological data on memory span is cited to demonstrate that advanced ESL students…

The Ritz - Sublaminate Generalized Unified Formulation approach for piezoelectric composite plates

NASA Astrophysics Data System (ADS)

D'Ottavio, Michele; Dozio, Lorenzo; Vescovini, Riccardo; Polit, Olivier

2018-01-01

This paper extends to composite plates including piezoelectric plies the variable kinematics plate modeling approach called Sublaminate Generalized Unified Formulation (SGUF). Two-dimensional plate equations are obtained upon defining a priori the through-thickness distribution of the displacement field and electric potential. According to SGUF, independent approximations can be adopted for the four components of these generalized displacements: an Equivalent Single Layer (ESL) or Layer-Wise (LW) description over an arbitrary group of plies constituting the composite plate (the sublaminate) and the polynomial order employed in each sublaminate. The solution of the two-dimensional equations is sought in weak form by means of a Ritz method. In this work, boundary functions are used in conjunction with the domain approximation expressed by an orthogonal basis spanned by Legendre polynomials. The proposed computational tool is capable to represent electroded surfaces with equipotentiality conditions. Free-vibration problems as well as static problems involving actuator and sensor configurations are addressed. Two case studies are presented, which demonstrate the high accuracy of the proposed Ritz-SGUF approach. A model assessment is proposed for showcasing to which extent the SGUF approach allows a reduction of the number of unknowns with a controlled impact on the accuracy of the result.

Construction Foundation Report, Grand River, Bowman-Haley Project, North Dakota. Volume 1. Text, Drawings, Photos.

DTIC Science & Technology

1985-05-01

tamping rollers. Final compaction was by rubber -t ired rollers. Compaction was to 95% of maximum density. Time between placing the 6" layers and...taree ue go dscribe*he:. 0 IoldNYeRAEL Boreast ol bsnc of eater readngs in the Iiraphic Log ’G I CAYI CQ 5A esL.- ADS@ * nbr ; i cneeeiItt be oetrued O

English-as-a-Second Language (ESL) nursing student success: a critical review of the literature.

PubMed

Olson, Mary Angela

2012-01-01

Many English-as-a-Second Language (ESL) nursing students struggle in nursing school for a multitude of reasons. The purpose of this critical review of the literature is to identify barriers and discover bridges to ESL nursing student success. Twenty-five articles were identified for the review. Language barriers were identified as the single most significant obstacle facing the ESL nursing student. Bridges to ESL nursing student success include enhancing language development and acculturation into the American mainstream culture. A broad range of strategies to promote student success are outlined and the role of the nurse educator in ESL nursing student success is also addressed.

Canada's Golden Horseshoe: An ESL/Geography Module (Teacher's Guide).

ERIC Educational Resources Information Center

Allen, Patrick; Howard, Joan

A teacher's guide to an English as a second language (ESL) and geography module entitled "Canada's Golden Horseshoe" is presented. ESL modules are multimedia kits designed to integrate the study of ESL and communication skills in specific subject areas of the curriculum. This module deals with a geographical region, important both to…

Learning From a Distance: U-Maine & ESL Go Electronic.

ERIC Educational Resources Information Center

Berube, Barney

Most teachers of English as a Second Language (ESL) in Maine live over 30 miles from the nearest University of Maine campus. While the Maine Department of Education has been offering intensive ESL teacher training courses, a lack of qualified ESL teachers persists. The advent of microwave transmission means more opportunities for teacher training…

Participatory Legitimacy in ESL Practice and the Use of Coping Strategies

ERIC Educational Resources Information Center

Yeh, Ling-Miao

2014-01-01

This study looked at ESL adult speakers' use of coping strategies in their conversations with native speakers in the United States, as a counter-discourse. More specifically, the discursive negotiation strategies used by 6 ESL adult speakers of varied ethnicities and linguistic backgrounds were analyzed, both inside and outside ESL classrooms. The…

A Sourcebook for Integrating ESL and Content Instruction Using the Foresee Approach.

ERIC Educational Resources Information Center

Kidd, Richard; Marquardson, Brenda

This sourcebook presents an approach to teaching students of English as a Second Language (ESL) that integrates communicative competence, cognitive and academic language development, and content instruction. It is intended for use by elementary school teachers of ESL and regular classroom teachers whose classes contain ESL students. An…

ESL Students in California Public Higher Education. ICAS ESL Task Force Report

ERIC Educational Resources Information Center

Online Submission, 2006

2006-01-01

The enclosed English as a Second Language (ESL) Task Force Report represents a response to questions raised by some educators and legislators about ESL programs, practices, and support services across the three California postsecondary systems: the California Community Colleges (CCCs), the California State Universities (CSUs), and the University…

ESL, EFL and Bilingual Education: Exploring Historical, Sociocultural, Linguistic, and Instructional Foundations

ERIC Educational Resources Information Center

Zimmerman, Lynn W.

2010-01-01

This collection of essays examines the historical, social, cultural, and educational foundations of ESL/EFL/Bilingual Education. The four themes of this book are: (1) Historical, Legal and Political Foundations of Bilingual/ESL Education; (2) Linguistic and Sociocultural Issues in ESL/EFL Education; (3) Educational Reform and English Language…

Professionalism Prevails in Adult Education ESL Classrooms

ERIC Educational Resources Information Center

Brown, Megan C.; Bywater, Kathleen

2010-01-01

The purpose of this report is to explore the issue of professionalism of adult education ESL educators and uncover any inequities. The arc of this exploration describes the history of adult education, the current state of adult education ESL professionals, and the direction in which ESL adult educators appear to be heading. The results illustrate…

Antiepileptic drugs-induced hyponatremia: Review and analysis of 560 hospitalized patients.

PubMed

Intravooth, Tassanai; Staack, Anke M; Juerges, Katharina; Stockinger, Jakob; Steinhoff, Bernhard J

2018-07-01

Recent evidence suggests that eslicarbazepine acetate (ESL) might be an appropriate alternative to carbamazepine (CBZ) and oxcarbazepine (OXC) due to its better safety profile. Hyponatremia may be one of the limiting safety problems in CBZ and OXC whereas it has been indicated that ESL is less sensitive for the adverse event. Since our clinical experience is different we investigated the incidence of hyponatremia in 560 consecutive adult inpatients treated at our center in 2015 by reviewing their medical records. Only CBZ, OXC and ESL were associated with hyponatremia. The incidence of hyponatremia induced by ESL was not statistically different from that induced by OXC (43% of patients with OXC and 33% with ESL, p > 0.05). Both were associated with hyponatremia more often than CBZ (16%). OXC-induced hyponatremia was dose-related, ESL-induced hyponatremia was not. Furthermore, both OXC- and ESL-induced hyponatremia occurred particularly often in elderly epilepsy patients. Thus, for elderly patients, both OXC and ESL should be considered with caution. Copyright © 2018 Elsevier B.V. All rights reserved.

Clinical expectations: what facilitators expect from ESL students on clinical placement.

PubMed

San Miguel, Caroline; Rogan, Fran

2012-03-01

Many nursing students for whom English is a second language (ESL) face challenges related to communication on clinical placement and although clinical facilitators are not usually trained language assessors, they are often in a position of needing to assess ESL students' clinical language performance. Little is known, however, about the particular areas of clinical performance facilitators focus on when they are assessing ESL students. This paper discusses the results of a study of facilitators' written assessment comments about the clinical performance of a small group of ESL nursing students over a two and a half year period. These comments were documented on students' clinical assessment forms at the end of each placement. The results provide a more detailed insight into facilitators' expectations of students' language performance and the particular challenges faced by ESL students and indicate that facilitators have clear expectations of ESL students regarding communication, learning styles and professional demeanour. These findings may help both ESL students and their facilitators better prepare for clinical placement. Copyright © 2011 Elsevier Ltd. All rights reserved.

Soy Leaf Extract Containing Kaempferol Glycosides and Pheophorbides Improves Glucose Homeostasis by Enhancing Pancreatic β-Cell Function and Suppressing Hepatic Lipid Accumulation in db/db Mice.

PubMed

Li, Hua; Ji, Hyeon-Seon; Kang, Ji-Hyun; Shin, Dong-Ha; Park, Ho-Yong; Choi, Myung-Sook; Lee, Chul-Ho; Lee, In-Kyung; Yun, Bong-Sik; Jeong, Tae-Sook

2015-08-19

This study investigated the molecular mechanisms underlying the antidiabetic effect of an ethanol extract of soy leaves (ESL) in db/db mice. Control groups (db/+ and db/db) were fed a normal diet (ND), whereas the db/db-ESL group was fed ND with 1% ESL for 8 weeks. Dietary ESL improved glucose tolerance and lowered plasma glucose, glycated hemoglobin, HOMA-IR, and triglyceride levels. The pancreatic insulin content of the db/db-ESL group was significantly greater than that of the db/db group. ESL supplementation altered pancreatic IRS1, IRS2, Pdx1, Ngn3, Pax4, Ins1, Ins2, and FoxO1 expression. Furthermore, ESL suppressed lipid accumulation and increased glucokinase activity in the liver. ESL primarily contained kaempferol glycosides and pheophorbides. Kaempferol, an aglycone of kaempferol glycosides, improved β-cell proliferation through IRS2-related FoxO1 signaling, whereas pheophorbide a, a product of chlorophyll breakdown, improved insulin secretion and β-cell proliferation through IRS1-related signaling with protein kinase A in MIN6 cells. ESL effectively regulates glucose homeostasis by enhancing IRS-mediated β-cell insulin signaling and suppressing SREBP-1-mediated hepatic lipid accumulation in db/db mice.

The use of embryonic cells in the treatment of osteochondral defects of the knee: an ovine in vivo study.

PubMed

Manunta, Andrea Fabio; Zedde, Pietro; Pilicchi, Susanna; Rocca, Stefano; Pool, Roy R; Dattena, Maria; Masala, Gerolamo; Mara, Laura; Casu, Sara; Sanna, Daniela; Manunta, Maria Lucia; Passino, Eraldo Sanna

2016-01-01

the aim of this study was to determine whether local delivery of embryonic stem-like (ESL) cells into osteochondral defects in the femoral condyles of sheep would enhance regeneration of hyaline articular cartilage. male ESL cells embedded in fibrin glue were engrafted into osteochondral defects in the medial condyles (ESL-M) of the left femur in 22 ewes. An identical defect was created in the medial condyle of the contralateral stifle joint and left untreated as a control (empty defect, ED). The ewes were divided into 5 groups. Four sheep each were euthanized at 1, 2, 6, and 12 months from surgery, and 6 ewes were euthanized 24 months post-implantation. To study the effect of varying loads on the long-term regeneration process, an identical defect was also created and ESL cell engraftment performed in the lateral condyle (ESL-L) of the left stifle joint of the animals in the 12- and 24-month groups. The evaluation of regenerated tissue was performed by biomechanical, macroscopic, histological, immunohistochemical (collagen type II) and fluorescent in situ hybridization (FISH) assays. no significant differences were found between treated and control sites in the biomechanical assays at any time point. ESL cell grafts showed significantly greater macroscopic evidence of regeneration as compared to controls at 24 months after surgery; significantly better histological evidence of repair in ESL-M samples versus controls was found throughout the considered period. At 24 months from surgery there was significantly improved integration of graft edges with the host tissue in the ESL-M as compared to the ESL-L samples, demonstrating that load bearing positively affects the long-term regeneration process. ESL cells enhanced the regeneration of hyaline cartilage. FISH confirmed that the regenerative tissue originated from ESL cells. ESL cells are able to self-renew for prolonged periods without differentiation and, most importantly, to differentiate into a large variety of tissues.

The use of embryonic cells in the treatment of osteochondral defects of the knee: an ovine in vivo study

PubMed Central

MANUNTA, ANDREA FABIO; ZEDDE, PIETRO; PILICCHI, SUSANNA; ROCCA, STEFANO; POOL, ROY R.; DATTENA, MARIA; MASALA, GEROLAMO; MARA, LAURA; CASU, SARA; SANNA, DANIELA; MANUNTA, MARIA LUCIA; PASSINO, ERALDO SANNA

2016-01-01

Purpose the aim of this study was to determine whether local delivery of embryonic stem-like (ESL) cells into osteochondral defects in the femoral condyles of sheep would enhance regeneration of hyaline articular cartilage. Methods male ESL cells embedded in fibrin glue were engrafted into osteochondral defects in the medial condyles (ESL-M) of the left femur in 22 ewes. An identical defect was created in the medial condyle of the contralateral stifle joint and left untreated as a control (empty defect, ED). The ewes were divided into 5 groups. Four sheep each were euthanized at 1, 2, 6, and 12 months from surgery, and 6 ewes were euthanized 24 months post-implantation. To study the effect of varying loads on the long-term regeneration process, an identical defect was also created and ESL cell engraftment performed in the lateral condyle (ESL-L) of the left stifle joint of the animals in the 12- and 24-month groups. The evaluation of regenerated tissue was performed by biomechanical, macroscopic, histological, immunohistochemical (collagen type II) and fluorescent in situ hybridization (FISH) assays. Results no significant differences were found between treated and control sites in the biomechanical assays at any time point. ESL cell grafts showed significantly greater macroscopic evidence of regeneration as compared to controls at 24 months after surgery; significantly better histological evidence of repair in ESL-M samples versus controls was found throughout the considered period. At 24 months from surgery there was significantly improved integration of graft edges with the host tissue in the ESL-M as compared to the ESL-L samples, demonstrating that load bearing positively affects the long-term regeneration process. Conclusions ESL cells enhanced the regeneration of hyaline cartilage. FISH confirmed that the regenerative tissue originated from ESL cells. Clinical Relevance ESL cells are able to self-renew for prolonged periods without differentiation and, most importantly, to differentiate into a large variety of tissues. PMID:27602346

Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs.

PubMed

Mintzer, Scott; Wechsler, Robert T; Rogin, Joanne B; Gidal, Barry E; Schwab, Matthias; Ben-Menachem, Elinor; Carreño, Mar; da Silva, Patrício Soares; Moreira, Joana; Li, Yan; Blum, David; Grinnell, Todd

2018-03-01

To evaluate the effects of eslicarbazepine acetate (ESL) on lipid metabolism and to determine whether reduced statin exposure during ESL therapy has clinical consequences. We conducted a post-hoc analysis of pooled data for serum lipids (laboratory values) from three phase III, multicenter, randomized, double-blind, placebo-controlled trials of adjunctive ESL therapy (400, 800, or 1200 mg once daily) in patients with treatment-refractory partial-onset seizures. Changes from baseline in serum lipid levels were analyzed according to use of statins and/or enzyme-inducing antiepileptic drugs (EIAEDs) during the baseline period. In total, 426 and 1021 placebo- and ESL-treated patients, respectively, were included in the analysis. With regard to the changes from baseline in serum concentrations, there were statistically significant differences between the placebo and ESL 1200 mg QD groups, for both total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C), but the effect sizes were small (+4.1 mg/dL and +1.8 mg/dL, respectively). A small but significant difference in low-density lipoprotein cholesterol (LDL-C; -5.0 mg/dL) was observed between the ESL 400 mg QD group and the placebo group. In patients not taking a concomitant EIAED, there were no changes with ESL 400 mg QD, but modest and statistically significant increases in cholesterol fractions (TC, LDL-C and HDL-C) with ESL 800 mg QD (<6 mg/dL) and ESL 1200 mg QD (<10 mg/dL). ESL had no consistent effect on lipids in patients taking a concomitant EIAED. In patients taking statins during baseline, there were no clinically relevant changes in serum lipids during use of ESL, although the subgroups were small. These results suggest that ESL does not appear to have clinically significant effects on serum lipids, nor does the pharmacokinetic interaction between ESL and statins have an impact on serum lipid concentrations. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Incidence of seizure exacerbation and seizures reported as adverse events during adjunctive treatment with eslicarbazepine acetate: A pooled analysis of three Phase III controlled trials.

PubMed

Carreño, Mar; Benbadis, Selim; Rocha, Francisco; Blum, David; Cheng, Hailong

2017-12-01

To investigate whether adjunctive eslicarbazepine acetate (ESL) could lead to exacerbation of seizures in some patients. Post-hoc analysis of data pooled from three Phase III trials of adjunctive ESL (studies 301, 302, and 304) for refractory partial-onset seizures (POS). Following an 8-week baseline period, patients were randomized to receive placebo or ESL 400, 800, or 1,200 mg once daily (2-week titration, 12-week maintenance, 2-4 week tapering-off periods). Patient seizure diary data and seizure treatment-emergent adverse event (TEAE) reports were pooled for analysis. The modified intent-to-treat and safety populations comprised 1,410 patients and 1,447 patients, respectively. Titration period : Compared with placebo (32/21%), significantly smaller proportions of patients taking ESL 800 mg (20/15%) and 1,200 mg (22/12%) had a ≥25/≥50% increase in standardized seizure frequency (SSF) from baseline; there was no significant difference between placebo and ESL 400 mg. Maintenance period : Compared with placebo (20%), significantly smaller proportions of patients taking ESL (400 mg, 12%; 800 mg, 12%; 1,200 mg, 14%) had an increase in SSF ≥25%. When evaluating ≥50% increases in SSF, only ESL 800 mg (7%) was significantly different from placebo (12%). Some patients had no secondarily generalized tonic-clonic (sGTC) seizures during baseline but had ≥1 sGTC seizure during maintenance treatment (placebo, 11%; ESL 400 mg, 5%; 800 mg, 10%; 1,200 mg, 5%). Fewer patients had a ≥25% increase in sGTC seizure frequency with ESL (400 mg, 11%; 800 mg, 9%; 1,200 mg, 14%) versus placebo (19%). The incidence of seizures reported as TEAEs was low in all treatment groups; incidences were generally lower with ESL versus placebo. Tapering-off period : Similar proportions of patients taking ESL and placebo had a ≥25/≥50% increase in SSF. Seizure TEAE incidence was numerically higher with ESL versus placebo. Treatment with adjunctive ESL does not appear to aggravate POS or sGTC seizures.

Psychiatric and cognitive adverse events: A pooled analysis of three phase III trials of adjunctive eslicarbazepine acetate for partial-onset seizures.

PubMed

Andermann, Eva; Biton, Victor; Benbadis, Selim R; Shneker, Bassel; Shah, Aashit K; Carreño, Mar; Trinka, Eugen; Ben-Menachem, Elinor; Biraben, Arnaud; Rocha, Francisco; Gama, Helena; Cheng, Hailong; Blum, David

2018-05-01

To evaluate the nature and incidence of psychiatric and cognitive adverse events (AEs) reported with eslicarbazepine acetate (ESL) used as adjunctive treatment for refractory partial-onset seizures (POS) in adults. This was a post-hoc analysis of data pooled from three randomized double-blind, placebo-controlled trials (BIA-2093-301, -302, -304). After an 8-week baseline period, patients received placebo or adjunctive ESL 400mg (studies 301 and 302 only), 800mg, or 1200mg once daily (QD) for 14weeks (2-week titration period, 12-week maintenance period). Psychiatric and cognitive AEs were identified from individual patient data. Suicidality was also evaluated using the Columbia-Classification Algorithm of Suicide Assessment (C-CASA), or the Columbia-Suicide Severity Rating Scale (C-SSRS). P-values were obtained using the chi-square test of independence or Fisher's exact test, without correcting for multiplicity. The analysis population included 1447 patients (ESL, n=1021; placebo, n = 426). Psychiatric treatment-emergent AEs (TEAEs) occurred in 10.8% of patients receiving ESL, and in a comparable proportion (10.3%) of patients receiving placebo (p=0.802). The incidence of depression and suicidality-related TEAEs was higher for ESL (7.4%) vs. placebo (3.8%) (p=0.009). The occurrence of these TEAEs differed between treatment groups (p = 0.010), but there was no notable trend between increasing ESL dose and increasing incidence of depression and suicidality-related TEAEs. Aggression/hostility-related TEAEs occurred in <0.1% of patients taking ESL vs. 0.9% taking placebo. The incidence of cognitive TEAEs was higher for ESL (7.1%) vs. placebo (4.0%) (p=0.023); incidences of memory impairment, attention disturbance, apathy, and aphasia were higher for ESL 1200mg than for other treatment groups. Incidences of psychiatric and cognitive serious AEs (SAEs) were 0.6% and 0.2% with ESL, and 0.5% and 0% with placebo, respectively. Psychiatric and cognitive TEAEs leading to discontinuation occurred in 1.9% and 1.4% of patients taking ESL, and 0.7% and 0.5% taking placebo, respectively. In phase III clinical trials of adjunctive ESL for treatment-refractory POS, psychiatric and cognitive TEAEs were reported infrequently with ESL and placebo. The incidences of depression and suicidality-related TEAEs and of cognitive TEAEs were higher for patients taking ESL vs. placebo. Incidences of psychiatric and cognitive SAEs, and TEAEs leading to discontinuation, were low with ESL and placebo. Copyright © 2017. Published by Elsevier Inc.

An Alignment of the Canadian Language Benchmarks to the BC ESL Articulation Levels. Final Report - January 2007

ERIC Educational Resources Information Center

Barbour, Ross; Ostler, Catherine; Templeman, Elizabeth; West, Elizabeth

2007-01-01

The British Columbia (BC) English as a Second Language (ESL) Articulation Committee's Canadian Language Benchmarks project was precipitated by ESL instructors' desire to address transfer difficulties of ESL students within the BC transfer system and to respond to the recognition that the Canadian Language Benchmarks, a descriptive scale of ESL…

Factors Inhibiting ESL Learners from Passing California High School Exit Examination: A Narrative Inquiry

ERIC Educational Resources Information Center

Puente, Belinda

2017-01-01

The problem was that Hispanic English Second Language (ESL) students enrolled in the ESL program had consistently failed the California High School Exit Examination (CASHEE) in greater numbers than their cohorts. The purpose of this qualitative narrative inquiry was to explore the life stories of Hispanic ESL students in identifying the factors…

Strangers and Professionals: Positioning Discourse in ESL Teachers' Work

ERIC Educational Resources Information Center

Haneda, Mari; Nespor, Jan

2013-01-01

English Language Learners (ELLs) usually spend most of the school day with regular classroom teachers. The ability of English-as-a-second-language (ESL) teachers to help these students, then, depends in part on their ability to influence how the classroom teachers think of ELL students and ESL itself. One way ESL teachers do this is through…

Designing Websites for ESL Learners: A Usability Testing Study

ERIC Educational Resources Information Center

Liu, Min; Traphagan, Tomoko; Huh, Jin; Koh, Young Ihn; Choi, Gilok; McGregor, Allison

2008-01-01

The purpose of this paper is to report on a usability study for ESL websites conducted to gain insights from learners of English as a second language (ESL) as they interacted with specific sites. Five carefully selected ESL sites were tested by 10 different users generating a total of fifty testing sessions. Two major research questions guided the…

The Short Circuit Hypothesis of ESL Reading--Or when Language Competence Interferes with Reading Performance.

ERIC Educational Resources Information Center

Clarke, Mark A.

1980-01-01

Examines a sampling of current ESL reading instruction practices, addressing the concern that the lack of a generally accepted theory of L2 reading constitutes a major obstacle to teaching and testing ESL reading skills. Summarizes the results of two studies and discusses their implications for ESL teachers. (MES)

English as a Second Language (ESL) in Alberta Schools. Parent Handbook.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton.

Schools in Alberta provide English-as-a-Second-Language (ESL) program support to immigrant students while they are adjusting to Canadian culture and learning the English language. This booklet is for parents who are new to Alberta, whose children are learning ESL and/or who need more information about ESL program support. A description of the…

Electronic Text and English as a Second Language Environments. CELA Research Report.

ERIC Educational Resources Information Center

Meskill, Carla; Mossop, Jonathan; Bates, Richard

This report investigates how technologies such as computers, multimedia, and telecommunications can be effective tools for English-as-a-Second-Language (ESL) instruction. Both ESL and non-ESL teachers are coming to view these technologies as a means by which ESL learners who cannot otherwise participate in class activities can be actively involved…

E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-β in the bone microenvironment.

PubMed

Yang, Tao; Grafe, Ingo; Bae, Yangjin; Chen, Shan; Chen, Yuqing; Bertin, Terry K; Jiang, Ming-Ming; Ambrose, Catherine G; Lee, Brendan

2013-04-30

TGF-β is abundantly produced in the skeletal system and plays a crucial role in skeletal homeostasis. E-selectin ligand-1 (ESL-1), a Golgi apparatus-localized protein, acts as a negative regulator of TGF-β bioavailability by attenuating maturation of pro-TGF-β during cartilage homeostasis. However, whether regulation of intracellular TGF-β maturation by ESL-1 is also crucial during bone homeostasis has not been well defined. Here, we show that Esl-1(-/-) mice exhibit a severe osteopenia with elevated bone resorption and decreased bone mineralization. In primary culture, Esl-1(-/-) osteoclast progenitors show no difference in osteoclastogenesis. However, Esl-1(-/-) osteoblasts show delayed differentiation and mineralization and stimulate osteoclastogenesis more potently in the osteoblast-osteoclast coculture, suggesting that ESL-1 primarily acts in osteoblasts to regulate bone homeostasis. In addition, Esl-1(-/-) calvaria exhibit an elevated mature TGF-β/pro-TGF-β ratio, with increased expression of TGF-β downstream targets (plasminogen activator inhibitor-1, parathyroid hormone-related peptide, connective tissue growth factor, and matrix metallopeptidase 13, etc.) and a key regulator of osteoclastogenesis (receptor activator of nuclear factor κB ligand). Moreover, in vivo treatment with 1D11, a pan-TGF-β antibody, significantly improved the low bone mass of Esl-1(-/-) mice, suggesting that elevated TGF-β signaling is the major cause of osteopenia in Esl-1(-/-) mice. In summary, our study identifies ESL-1 as an important regulator of bone remodeling and demonstrates that the modulation of TGF-β maturation is pivotal in the maintenance of a homeostatic bone microenvironment and for proper osteoblast-osteoclast coupling.

EARLY-ESLI study: Long-term experience with eslicarbazepine acetate after first monotherapy failure.

PubMed

Villanueva, V; Bermejo, P; Montoya, J; Toledo, M; Gómez-Ibáñez, A; Garcés, M; Vilella, L; López-González, F J; Rodriguez-Osorio, X; Campos, D; Martínez, P; Giner, P; Zurita, J; Rodríguez-Uranga, J; Ojeda, J; Mauri, J A; Camacho, J L; Ruiz-Giménez, J; Poza, J J; Massot-Tarrús, A; Galiano, M L; Bonet, M

2017-09-01

Evaluate real-life experience with eslicarbazepine acetate (ESL) after first monotherapy failure in a large series of patients with focal epilepsy. Multicentre, retrospective, 1-year, observational study in patients older than 18 years, with focal epilepsy, who had failed first antiepileptic drug monotherapy and who received ESL. Data from clinical records were analysed at baseline, 3, 6 and 12 months to assess effectiveness and tolerability. Eslicarbazepine acetate was initiated in 253 patients. The 1-year retention rate was 92.9%, and the final median dose of ESL was 800 mg. At 12 months, 62.3% of patients had been seizure free for 6 months; 37.3% had been seizure free for 1 year. During follow-up, 31.6% of the patients reported ESL-related adverse events (AEs), most commonly somnolence (8.7%) and dizziness (5.1%), and 3.6% discontinued due to AEs. Hyponatraemia was observed in seven patients (2.8%). After starting ESL, 137 patients (54.2%) withdrew the prior monotherapy and converted to ESL monotherapy; 75.9% were seizure free, 87.6% were responders, 4.4% worsened, and 23.4% reported ESL-related AEs. Use of ESL after first monotherapy failure was associated with an optimal seizure control and tolerability profile. Over half of patients were converted to ESL monotherapy during follow-up. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Summary report for the Engineering Script Language (ESL)

NASA Technical Reports Server (NTRS)

1990-01-01

The following subject areas are covered: ESL methodology concept; ESL specification; user interface description; engineering scripting language command statements specification; and recommendations for further research and development.

Development of Teaching Beliefs and the Focus of Change in the Process of Pre-Service ESL Teacher Education

ERIC Educational Resources Information Center

Tang, Eunice Lai-Yiu; Lee, John Chi-Kin; Chun, Cecilia Ka-Wai

2012-01-01

This study sets out to investigate how pre-service ESL teachers shape their beliefs in the process of experimenting with new teaching methods introduced in the teacher education programme. A 4-year longitudinal study was conducted with four randomly selected ESL pre-service teachers. Their theoretical orientations of ESL instruction were tracked…

Eligibility and Programming in Chapter I English as a Second Language (E.S.L.) Programs, 1988-89. OREA Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; Stern, Lucia

Chapter I/Pupils with Compensatory Educational Needs programs in English as a Second Language (ESL) served students at 78 high schools in New York City, supplementing tax-levy-funded ESL classes in those schools serving limited-English-proficient (LEP) students. Chapter I of the Educational Consolidation and Improvement Act funded ESL and…

Computer simulation to predict energy use, greenhouse gas emissions and costs for production of extended shelf-life (ESL) milk using microfiltration

USDA-ARS?s Scientific Manuscript database

Extended shelf-life (ESL) milk has a shelf life between that of high-temperature short-time (HTST) and ultrahigh temperature (UHT) pasteurized milk. ESL milk is usually pasteurized at temperatures exceeding 125 deg C which may give the milk a cooked taste. ESL milk produced using crossflow microfilt...

Could laser-assisted dissection of the pre-epiglottic space affect functional outcome after ESL?

PubMed

Bertolin, Andy; Lionello, Marco; Russo, Simone; Rizzotto, Giuseppe; Lucioni, Marco

2018-06-01

To evaluate the effect of preepiglottic space (PES) dissection in the endoscopic supraglottic laryngectomy (ESL). A retrospective cohort study. We retrospectively compared 15 patients who underwent ESL with 15 patients matched for clinical stage who underwent open partial horizontal laryngectomy (OPHL). The functional outcomes were assessed in terms of hospital stay; need for nasal feeding tube (NFT) and tracheostomy, as well as duration of their use; postoperative complications; aspiration pneumonia rates; voice quality; and dysphagia. Among the ESL cases, combined dissection of the epiglottis and PES (type III) had a negative impact on functional outcomes. ESL patients experienced shorter hospital stays, as well as shorter use of NFT and tracheostomy, than patients who had OPHL. Combined dissection of the epiglottis and PES (ESL type III) negatively affected functional outcome in patients undergoing ESL, a procedure generally related to significantly better functional outcomes than OPHL type I. 4. Laryngoscope, 128:1371-1378, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

Extreme sea level implications of 1.5 °C, 2.0 °C, and 2.5 °C temperature stabilization targets in the 21st and 22nd centuries

NASA Astrophysics Data System (ADS)

Rasmussen, D. J.; Bittermann, Klaus; Buchanan, Maya K.; Kulp, Scott; Strauss, Benjamin H.; Kopp, Robert E.; Oppenheimer, Michael

2018-03-01

Sea-level rise (SLR) is magnifying the frequency and severity of extreme sea levels (ESLs) that can cause coastal flooding. The rate and amount of global mean sea-level (GMSL) rise is a function of the trajectory of global mean surface temperature (GMST). Therefore, temperature stabilization targets (e.g. 1.5 °C and 2.0 °C of warming above pre-industrial levels, as from the Paris Agreement) have important implications for coastal flood risk. Here, we assess, in a global network of tide gauges, the differences in the expected frequencies of ESLs between scenarios that stabilize GMST warming at 1.5 °C, 2.0 °C, and 2.5 °C above pre-industrial levels. We employ probabilistic, localized SLR projections and long-term hourly tide gauge records to estimate the expected frequencies of historical and future ESLs for the 21st and 22nd centuries. By 2100, under 1.5 °C, 2.0 °C, and 2.5 °C GMST stabilization, the median GMSL is projected to rise 48 cm (90% probability of 28-82 cm), 56 cm (28-96 cm), and 58 cm (37-93 cm), respectively. As an independent comparison, a semi-empirical sea level model calibrated to temperature and GMSL over the past two millennia estimates median GMSL rise within 7-8 cm of these projections. By 2150, relative to the 2.0 °C scenario and based on median sea level projections, GMST stabilization of 1.5 °C spares the inundation of lands currently home to about 5 million people, including 60 000 individuals currently residing in Small Island Developing States. We quantify projected changes to the expected frequency of historical 10-, 100-, and 500-year ESL events using frequency amplification factors that incorporate uncertainty in both local SLR and historical return periods of ESLs. By 2150, relative to a 2.0 °C scenario, the reduction in the frequency amplification of the historical 100 year ESL event arising from a 1.5 °C GMST stabilization is greatest in the eastern United States, with ESL event frequency amplification being reduced by about half at most tide gauges. In general, smaller reductions are projected for Small Island Developing States.

An Overview of the MSFC Electrostatic Levitation Facility

NASA Technical Reports Server (NTRS)

Rogers, J. R.; Robinson, M. B.; Hyers, R. W.; Savage, L.; Rathz, T.

2000-01-01

Electrostatic levitation (ESL) provides a means to study molten materials in a contamination-free environment, including no contact with a container. Many phenomena important to materials science can be studied in the ESL. Solidification of metals, alloys and undercooled materials represent an important topic for research in the ESL. Recent studies of metals and alloys during solidification in the ESL are reported. Measurements include time, temperature and transformation of metallic glass-forming alloys, solidification velocities, and microstructure. This multimedia report includes a video clip showing processing in the ESL, with descriptions of the different segments in the text.

Prediction of efficacy for conversion from adjunctive therapy to monotherapy with eslicarbazepine acetate 800 mg once daily for partial-onset epilepsy

PubMed Central

Sunkaraneni, Soujanya; Passarell, Julie A; Ludwig, Elizabeth A; Fiedler-Kelly, Jill; Pitner, Janet K; Grinnell, Todd A; Blum, David

2017-01-01

Purpose Eslicarbazepine acetate (ESL) is a once-daily (QD) oral antiepileptic drug (AED) indicated for partial-onset seizures (POS). Clinical studies of gradual conversion to ESL 1,200 and 1,600 mg QD monotherapies were previously conducted in patients with POS who were not well-controlled by 1 or 2 AEDs. This report describes modeling and simulation of plasma eslicarbazepine (primary active metabolite of ESL) concentrations and time to monotherapy study exit to predict efficacy for conversion to ESL monotherapy at a lower dose of 800 mg, as an option for patients requiring or not tolerating higher doses since this regimen is effective in adjunctive therapy for POS. Patients and methods A previously developed population pharmacokinetic model for ESL monotherapy was used to predict minimum plasma eslicarbazepine concentration (Cmin) in 1,500 virtual patients taking 1 (n=1,000) or 2 (n=500) AEDs at baseline, treated with ESL 400 mg QD for 1 week, followed by 800 mg QD for 17 weeks (similar to ESL monotherapy trials where the other AEDs were withdrawn during the first 6 weeks following titration to the randomized ESL dose). Model-predicted Cmin as a time-varying covariate and number of baseline AEDs were used to determine the weekly probability of each patient meeting exit criteria (65.3% threshold) indicative of worsening seizure control in 500 simulated ESL monotherapy trials. A previously developed extended Cox proportional hazards exposure–response model was used to relate time-varying eslicarbazepine exposure to the time to study exit. Results For virtual patients receiving ESL monotherapy (800 mg QD), the 95% upper prediction limit for exit rate at 112 days of 34.9% in patients taking 1 AED at baseline was well below the 65.3% threshold from historical control trials, while the estimate for patients taking 2 AEDs (70.6%) was slightly above the historical control threshold. Conclusion This model-based assessment supports conversion to ESL 800 mg QD monotherapy for POS in adults taking 1 AED. For patients taking 2 concomitant AEDs, however, prescribers should consider maintenance doses of 1,200 or 1,600 mg ESL QD to reduce the likelihood of seizure worsening if conversion to ESL monotherapy is contemplated. PMID:28721105

Prediction of efficacy for conversion from adjunctive therapy to monotherapy with eslicarbazepine acetate 800 mg once daily for partial-onset epilepsy.

PubMed

Sunkaraneni, Soujanya; Passarell, Julie A; Ludwig, Elizabeth A; Fiedler-Kelly, Jill; Pitner, Janet K; Grinnell, Todd A; Blum, David

2017-01-01

Eslicarbazepine acetate (ESL) is a once-daily (QD) oral antiepileptic drug (AED) indicated for partial-onset seizures (POS). Clinical studies of gradual conversion to ESL 1,200 and 1,600 mg QD monotherapies were previously conducted in patients with POS who were not well-controlled by 1 or 2 AEDs. This report describes modeling and simulation of plasma eslicarbazepine (primary active metabolite of ESL) concentrations and time to monotherapy study exit to predict efficacy for conversion to ESL monotherapy at a lower dose of 800 mg, as an option for patients requiring or not tolerating higher doses since this regimen is effective in adjunctive therapy for POS. A previously developed population pharmacokinetic model for ESL monotherapy was used to predict minimum plasma eslicarbazepine concentration ( C min ) in 1,500 virtual patients taking 1 (n=1,000) or 2 (n=500) AEDs at baseline, treated with ESL 400 mg QD for 1 week, followed by 800 mg QD for 17 weeks (similar to ESL monotherapy trials where the other AEDs were withdrawn during the first 6 weeks following titration to the randomized ESL dose). Model-predicted C min as a time-varying covariate and number of baseline AEDs were used to determine the weekly probability of each patient meeting exit criteria (65.3% threshold) indicative of worsening seizure control in 500 simulated ESL monotherapy trials. A previously developed extended Cox proportional hazards exposure-response model was used to relate time-varying eslicarbazepine exposure to the time to study exit. For virtual patients receiving ESL monotherapy (800 mg QD), the 95% upper prediction limit for exit rate at 112 days of 34.9% in patients taking 1 AED at baseline was well below the 65.3% threshold from historical control trials, while the estimate for patients taking 2 AEDs (70.6%) was slightly above the historical control threshold. This model-based assessment supports conversion to ESL 800 mg QD monotherapy for POS in adults taking 1 AED. For patients taking 2 concomitant AEDs, however, prescribers should consider maintenance doses of 1,200 or 1,600 mg ESL QD to reduce the likelihood of seizure worsening if conversion to ESL monotherapy is contemplated.

The Invisible Multilingual Teacher: The Contribution of Language Background to Australian ESL Teachers' Professional Knowledge and Beliefs

ERIC Educational Resources Information Center

Ellis, Elizabeth M.

2004-01-01

English as a second language (ESL) is taught in Australia to adult learners of mixed language backgrounds through the medium of English, and there is currently no requirement that ESL teachers speak another language. This paper reports on a study which asked what advantages there may be for ESL teachers to have proficiency in two or more…

Making Content Accessible to Promote Second Language Acquisition: The ESL Intensive Program at Hostos Community College (CUNY).

ERIC Educational Resources Information Center

Diaz, Diana M.; Justicia, Nellie T.; Levine, Lewis

An English-as-a-Second-Language (ESL) Intensive Program was established at Hostos Community College, New York, to help accelerate students' acquisition of ESL by combining three semesters of the college's regular ESL program into two semesters. Each level of this program provides 15 hours of classroom instruction per week, a 6-hour reading and…

Effect of Dialogue Journal Writing through the Use of Conventional Tools and E-Mail on Writing Anxiety in the ESL Context

ERIC Educational Resources Information Center

Foroutan, Maryam; Noordin, Nooreen

2012-01-01

ESL/EFL Anxiety has been reported as one of the foremost factors affecting ESL learners' performance. Hence, identifying methods to assist language learners to alleviate their ESL anxiety deserve to be considered by the educators. This study compared the effect of dialogue journal writing (DJW) through two different modes of learning and teaching:…

Course-Taking Patterns of Latino ESL Students: Mobility and Mainstreaming in Urban Community Colleges in the United States

ERIC Educational Resources Information Center

Razfar, Aria; Simon, Jenny

2011-01-01

In most Western countries where English is the medium of instruction, there is a substantial gap in student success between immigrant English as a second language (ESL) students and non-ESL students. In the United States, this situation has been observed in particular with Latino ESL students. This article describes a longitudinal study of two…

Long-term safety and efficacy of eslicarbazepine acetate in patients with focal seizures: results of the 1-year ESLIBASE retrospective study.

PubMed

Villanueva, V; Serratosa, J M; Guillamón, E; Garcés, M; Giráldez, B G; Toledo, M; Salas-Puig, J; López González, F J; Flores, J; Rodríguez-Uranga, J; Castillo, A; Mauri, J A; Camacho, J L; López-Gomáriz, E; Giner, P; Torres, N; Palau, J; Molins, A

2014-09-01

Eslicarbazepine acetate (ESL) is a new antiepileptic drug (AED) licensed as adjunctive therapy in adults with partial-onset or focal seizures. To evaluate in a clinical practice setting the long-term efficacy and safety of ESL in patients with focal seizures. ESLIBASE was a retrospective study that included all patients with focal seizures who started ESL between January 2010 and July 2012 at 12 hospitals. ESL was prescribed individually according to real-life practice. Efficacy and safety were evaluated over 1 year. Switching from carbamazepine (CBZ) and oxcarbazepine (OXC) was assessed. Three hundred and twenty-seven patients were included; 78% of patients were taking ≥2 other AEDs at baseline. Most (87%) began ESL because of poor seizure control and 13% because of adverse events (AEs) with CBZ or OXC. After 1 year, 237 patients (72.4%) remained on ESL. At 3, 6 and 12 months, the responder rate was 46.3%, 57.9%, and 52.5%, and 21.0%, 28.0%, and 25.3% of patients were seizure free. The responder rate significantly increased when ESL was combined with a non-sodium channel-targeting drug (non-SC drug) (66.7%) versus an SC drug (47.7%; p<0.001). At 12 months, 40.7% of patients had ≥1 AE; AEs led to treatment discontinuation in 16.2%. Dizziness, nausea, and somnolence were the most common AEs. The tolerability profile improved in >50% of the patients who switched from CBZ or OXC to ESL because of AEs. ESL was well tolerated and effective in a real-world setting over 1 year. Side-effect profile improved when OXC and CBZ recipients were switched to ESL. Copyright © 2014 Elsevier B.V. All rights reserved.

E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-β in the bone microenvironment

PubMed Central

Yang, Tao; Grafe, Ingo; Bae, Yangjin; Chen, Shan; Chen, Yuqing; Bertin, Terry K.; Jiang, Ming-Ming; Ambrose, Catherine G.; Lee, Brendan

2013-01-01

TGF-β is abundantly produced in the skeletal system and plays a crucial role in skeletal homeostasis. E-selectin ligand-1 (ESL-1), a Golgi apparatus-localized protein, acts as a negative regulator of TGF-β bioavailability by attenuating maturation of pro–TGF-β during cartilage homeostasis. However, whether regulation of intracellular TGF-β maturation by ESL-1 is also crucial during bone homeostasis has not been well defined. Here, we show that Esl-1−/− mice exhibit a severe osteopenia with elevated bone resorption and decreased bone mineralization. In primary culture, Esl-1−/− osteoclast progenitors show no difference in osteoclastogenesis. However, Esl-1−/− osteoblasts show delayed differentiation and mineralization and stimulate osteoclastogenesis more potently in the osteoblast–osteoclast coculture, suggesting that ESL-1 primarily acts in osteoblasts to regulate bone homeostasis. In addition, Esl-1−/− calvaria exhibit an elevated mature TGF-β/pro–TGF-β ratio, with increased expression of TGF-β downstream targets (plasminogen activator inhibitor-1, parathyroid hormone-related peptide, connective tissue growth factor, and matrix metallopeptidase 13, etc.) and a key regulator of osteoclastogenesis (receptor activator of nuclear factor κB ligand). Moreover, in vivo treatment with 1D11, a pan–TGF-β antibody, significantly improved the low bone mass of Esl-1−/− mice, suggesting that elevated TGF-β signaling is the major cause of osteopenia in Esl-1−/− mice. In summary, our study identifies ESL-1 as an important regulator of bone remodeling and demonstrates that the modulation of TGF-β maturation is pivotal in the maintenance of a homeostatic bone microenvironment and for proper osteoblast–osteoclast coupling. PMID:23589896

A Correlational Study of a Reading Comprehension Program and Attrition Rates of ESL Nursing Students in Texas.

PubMed

Donnell, Wendy M

The purpose of this study was to examine the associations between English as a second language (ESL), a reading comprehension program, and attrition rates of nursing students. Higher attrition rates of ESL nursing students are an assumption, seemingly based on anecdotal evidence. Data reflecting ESL student attrition should be measured and analyzed so that students can be identified prior to attrition. A secondary analysis of a large database of 27 initial licensure programs in Texas was completed. Data analysis identified that ESL students who used a reading comprehension program were almost twice as likely to be off track or out of the program as ESL students who did not use the program. Nurse educators need to evaluate student profile characteristics in a comprehensive way when determining risk of attrition.

Transition from oxcarbazepine to eslicarbazepine acetate: A single center study.

PubMed

Mäkinen, Jussi; Rainesalo, Sirpa; Peltola, Jukka

2017-03-01

There is limited clinical evidence for comparison between oxcarbazepine (OXC) and eslicarbazepine acetate (ESL) in terms of tolerability, or how to execute the change from OXC to ESL. We report the process of transitioning patients with focal epilepsy from previous OXC treatment to ESL due to tolerability problems. The rationale for change from OXC is reported, and the outcome with respective to this rationale is analyzed in terms of tolerability and efficacy. The subjects were transitioned overnight from OXC to ESL in a hospital inpatient setting. An evaluation of the effects of the transition was made after 1 and 3 months. All adverse events (AEs) were recorded following the transition period. Subjects were classified by outcome in terms of AEs. Twenty-three subjects were transitioned from OXC to ESL. Fifteen patients OXC-related AEs reduced significantly after transition. Particularly, most of (93%) the AEs presented in the morning resolved after transition to ESL. No patient had an increase in seizure frequency following the transition. The incidence of ESL-related AEs was 39% at 1 month and 13% at 3 month follow-up; however, all patients continued ESL throughout the study period. This study demonstrates that patients suffering from OXC-related AEs improve in terms of tolerability after a switch to ESL with maintaining seizure control. This improvement is more pronounced if the OXC-related AEs are most evident following morning dosing of OXC. Transition can be safely executed in an outpatient setting.

34 CFR 668.153 - Administration of tests for students whose native language is not English or for persons with...

Code of Federal Regulations, 2010 CFR

2010-07-01

... program that is taught in English with an ESL component, and the student is enrolled in that program and the ESL component, the student must take either an ESL test approved under § 668.148(b), or a test in... enrolled in a program that is taught in English without an ESL component, or the student does not enroll in...

ESL Students' Perceptions of Their English Writing Proficiency and the Effects of Peer Review Training among Three Types of Students in a Community College ESL Composition Course

ERIC Educational Resources Information Center

Goldburg, Maxine E.

2012-01-01

Learner-centered methodology like peer review is problematic in the pluralism of the ESL classroom when teaching academic English composition. A distinct complication is the form writing instruction should take given the interaction and variations between ESL students' L1 background, experiences, schema, and the meaning of academic literacy in…

Eslicarbazepine acetate: its effectiveness as adjunctive therapy in clinical trials and open studies.

PubMed

Shorvon, S D; Trinka, E; Steinhoff, B J; Holtkamp, M; Villanueva, V; Peltola, J; Ben-Menachem, E

2017-03-01

Eslicarbazepine acetate (ESL) is a once-daily antiepileptic drug that is approved as adjunctive therapy in adults with focal-onset seizures. Following oral administration, ESL is rapidly metabolized to its active metabolite, eslicarbazepine, which acts primarily by enhancing slow inactivation of voltage-gated sodium channels. The efficacy and safety/tolerability of ESL in the adjunctive setting were established in a comprehensive Phase III program (n = 1702 randomized patients) and this evidence has been supported by several open studies (n = 864). ESL treatment has demonstrated improvements in health-related quality of life, in both randomized clinical trials and open studies. ESL has also been shown to be usually well tolerated and efficacious when used in the adjunctive setting in elderly patients. The effectiveness of ESL as the only add-on to antiepileptic drug monotherapy has been demonstrated in a multinational study (n = 219), subgroup analyses of which have also shown it to be efficacious and generally well tolerated in patients who had previously not responded to carbamazepine therapy. Open studies have also demonstrated improvements in tolerability in patients switched overnight from oxcarbazepine to ESL. Due to differences in pharmacokinetics, pharmacodynamics, and metabolism, there may be clinical situations in which it is appropriate to consider switching patients from oxcarbazepine or carbamazepine to ESL.

28 CFR 544.41 - Applicability: Who must attend the ESL program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... INSTITUTIONAL MANAGEMENT EDUCATION Mandatory English-as-a-Second Language Program (ESL) § 544.41 Applicability... may excuse from attending the ESL program. (b) Staff shall document in the inmate's education file the...

Redesigning nursing tutorials for ESL students: a pilot study.

PubMed

San Miguel, Caroline; Townsend, Lisa; Waters, Cheryl

2013-04-01

Increased enrolments of Bachelor of Nursing (BN) students who speak English as a second language (ESL) can help create a multilingual and culturally diverse workforce that is better prepared to meet the needs of increasingly diverse health populations. However, although ESL enrolments are increasing, attrition rates for ESL students tend to be higher than those of native speakers of English, partly due to academic failure. At the same time, concerns have been expressed in some quarters about the low levels of English language of entering students. As it is unlikely that language entry levels to university will be raised, sustainable programmes that help ESL students better meet the academic challenges they may face need to be developed. So far, models of ESL support have been mostly an adjunct to their degree, voluntary and not well attended. This paper discusses a model using tutorials integrated into the first year nursing curriculum that were specifically designed for ESL students with low levels of English language proficiency. The paper also examines students' perceptions of such tutorials, which they found beneficial to their learning.

First Language Composition Pedagogy in the Second Language Classroom: A Reassesment.

ERIC Educational Resources Information Center

Ross, Steven; And Others

1988-01-01

Evaluated the effectiveness of using native language (Japanese) based writing methods in English as a second language (ESL) classrooms. The methods compared included sentence combining and structural grammar instruction with journal writing, controlled composition writing with feedback on surface error, and peer reformulation. Journal writing, but…

Comments on Elsa Roberts Auerbach's "Reexamining English Only in the ESL Classroom."

ERIC Educational Resources Information Center

Polio, Charlene; Auerbach, Elsa Roberts

1994-01-01

Arguments for students' use of their first language as well as English in the English-as-a-Second-Language (ESL) classroom are reexamined. Pedagogical and political aspects of ESL instruction are noted. (LB)

Academic achievement and course taking among language minority youth in U.S. schools: Effects of ESL placement

PubMed Central

Callahan, Rebecca; Wilkinson, Lindsey; Muller, Chandra

2014-01-01

The 1974 Lau decision requires that U.S. public schools ensure a meaningful education for students learning English. English as a Second Language (ESL) placement is an institutional response to the linguistic needs of these students; however, its academic implications remain largely unexplored. Using nationally representative data from the Educational Longitudinal Study (ELS), the effects of ESL placement on college preparatory course enrollment and academic achievement of language minority students are estimated, first with fixed effects regression models and then with multi-level propensity score matching techniques. While numerous school and individual level factors beyond language proficiency predict ESL placement, a significant negative estimated effect of ESL placement on science enrollment and cumulative GPA is consistently found. Perhaps more important, however, no positive effects of ESL placement on the achievement of language minority youth are found when accounting for English proficiency and other potential covariates. PMID:25431506

Academic achievement and course taking among language minority youth in U.S. schools: Effects of ESL placement.

PubMed

Callahan, Rebecca; Wilkinson, Lindsey; Muller, Chandra

2010-03-01

The 1974 Lau decision requires that U.S. public schools ensure a meaningful education for students learning English. English as a Second Language (ESL) placement is an institutional response to the linguistic needs of these students; however, its academic implications remain largely unexplored. Using nationally representative data from the Educational Longitudinal Study (ELS), the effects of ESL placement on college preparatory course enrollment and academic achievement of language minority students are estimated, first with fixed effects regression models and then with multi-level propensity score matching techniques. While numerous school and individual level factors beyond language proficiency predict ESL placement, a significant negative estimated effect of ESL placement on science enrollment and cumulative GPA is consistently found. Perhaps more important, however, no positive effects of ESL placement on the achievement of language minority youth are found when accounting for English proficiency and other potential covariates.

Expression, purification, and refolding of active recombinant human E-selectin lectin and EGF domains in Escherichia coli.

PubMed

Kawano, Susumu; Iyaguchi, Daisuke; Okada, Chiaki; Sasaki, Yusuke; Toyota, Eiko

2013-06-01

Attempts to obtain active E-selectin from Escherichia coli (E. coli) have not yet been successful. In this study, we succeeded in expressing the recombinant lectin and epidermal growth factor domain fragments of human E-selectin (rh-ESLE) in E. coli on a large-scale. The rh-ESLE protein was expressed as an inactive form in the inclusion bodies. The inactive form of rh-ESLE was denatured and solubilized by 6 M guanidine hydrochloride and then purified by Ni(2+) affinity chromatography under denaturing conditions. Denatured rh-ESLE was then refolded by a rapid-dilution method using a large amount of refolding buffer, which contained arginine and cysteine/cystine. The refolded rh-ESLE showed binding affinity for sLe(X) (K(d) = 321 nM, B(max) = 1.9 pmol/μg protein). This result suggests that the refolded rh-ESLE recovered its native and functional structure.

Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: a historical-control phase III study.

PubMed

Jacobson, Mercedes P; Pazdera, Ladislav; Bhatia, Perminder; Grinnell, Todd; Cheng, Hailong; Blum, David

2015-03-28

Eslicarbazepine acetate (ESL, Aptiom®) is a once-daily (QD) anticonvulsant, approved as adjunctive treatment of partial-onset seizures (POS). It is extensively converted after oral administration to eslicarbazepine, and is believed to exert its effect through inhibition of voltage-gated sodium channels. The possible role of ESL as monotherapy to treat POS has not yet been established. This study was an 18-week, multicenter, randomized double-blind trial of gradual conversion to ESL monotherapy in adults with POS not well controlled by 1-2 antiepileptic drugs (AEDs), using historical data as the control. The study comprised an 8-week baseline period, a 2-week titration period, a 6-week AED conversion period, a 10-week monotherapy period, and either a 1-week taper period or optional entry to an open-label extension study. The primary endpoint compared the Kaplan-Meier (KM)-estimated 112-day exit rate with a threshold value calculated from the historical controls. There were 172 randomized patients; 154 (90%) entered the AED conversion period and 121 (70%) completed the study. The KM-estimated exit rates [confidence interval (CI)] were 15.6% [8.1-28.7%] for ESL 1200 mg, and 12.8% [7.5-21.5%] for ESL 1600 mg. The upper limits of the 95% CI KM-estimates were below the pre-specified threshold for historical control of 65.3%, indicating that ESL was efficacious in reducing seizure-related exits, compared with historical control. During the 18-week double-blind treatment period, median reductions in standardized seizure frequency occurred with ESL 1200 mg (36.1%) and ESL 1600 mg (47.5%). The responder rates (a 50% or greater reduction in seizure frequency from baseline) during the 18-week double-blind period and the monotherapy period, respectively, were 35.2% and 38.9% for ESL 1200 mg, and 46.0% and 46.0% for ESL 1600 mg. The overall adverse event profile was consistent with the known safety profile of ESL. These findings indicate that ESL monotherapy (1200 and 1600 mg QD) was efficacious and well tolerated in this study. NCT01091662 ; EudraCT No. 2010-018684-42.

Microvascular Channel Device to Study Aggressiveness in Prostate Cancer Metastasis

DTIC Science & Technology

2014-08-01

contributes to PCa’s distant metastasis, which is mediated via an E- selectin ligand, ESL -1. Consequently, the interaction of E-selectin/ ESL -1 transduces...cancer cell, E-selectin, ESL -1. OVERALL PROJECT SUMMARY A. Major goals of the project: 3 Task 1: Correlation of cancers’ aggressiveness with...Determination of the aggressive/metastatic related gene I. 1. ESL -1 expression is high in rolling cells and tissue When PCa cells come in contact with

Coordinated and unique functions of the E-selectin ligand ESL-1 during inflammatory and hematopoietic recruitment in mice

PubMed Central

Sreeramkumar, Vinatha; Leiva, Magdalena; Stadtmann, Anika; Pitaval, Christophe; Ortega-Rodríguez, Inés; Wild, Martin K.; Lee, Brendan; Zarbock, Alexander; Hidalgo, Andrés

2013-01-01

Beyond its well-established roles in mediating leukocyte rolling, E-selectin is emerging as a multifunctional receptor capable of inducing integrin activation in neutrophils, and of regulating various biological processes in hematopoietic precursors. Although these effects suggest important homeostatic contributions of this selectin in the immune and hematologic systems, the ligands responsible for transducing these effects in different leukocyte lineages are not well defined. We have characterized mice deficient in E-selectin ligand-1 (ESL-1), or in both P-selectin glycoprotein-1 (PSGL-1) and ESL-1, to explore and compare the contributions of these glycoproteins in immune and hematopoietic cell trafficking. In the steady state, ESL-1 deficiency resulted in a moderate myeloid expansion that became more prominent when both glycoproteins were eliminated. During inflammation, PSGL-1 dominated E-selectin binding, rolling, integrin activation, and extravasation of mature neutrophils, but only the combined deficiency in PSGL-1 and ESL-1 completely abrogated leukocyte recruitment. Surprisingly, we find that the levels of ESL-1 were strongly elevated in hematopoietic progenitor cells. These elevations correlated with a prominent function of ESL-1 for E-selectin binding and for migration of hematopoietic progenitor cells into the bone marrow. Our results uncover dominant roles for ESL-1 in the immature compartment, and a functional shift toward PSGL-1 dependence in mature neutrophils. PMID:24106206

Exploring ESL students' understanding of mathematics in the early years: factors that make a difference

NASA Astrophysics Data System (ADS)

Miller, Jodie; Warren, Elizabeth

2014-12-01

Students living in disadvantaged contexts and whose second language is English (ESL) are at risk of not succeeding in school mathematics. It has been internationally recognised that students' socioeconomic background and their achievements in mathematics is more pronounced for Australian students (Thomson et al. 2011). This gap is even more prominent for students who also have English as their second language (ESL). This paper explores the impact of the representations, oral language and engagement in mathematics (RoleM) learning experiences on ESL students' performance in mathematics in the early years (foundation-year 2). All students participating in the study are from disadvantaged contexts ( n = 461). The sample comprised 328 students who identified themselves as having English as a second language (ESL) and 133 mainstream students. Pre- and post-tests were conducted at the commencement and completion of each school year. All students demonstrated a significant improvement on their post-test scores, with ESL students displaying greater gains than the mainstream students. Additionally, students' results were meeting norm-referenced expectations for students of the same age. A hypothesised taxonomy was developed to further investigate which types of test items foundation ESL students displayed greatest gains. ESL students again outperformed the mainstream cohort on all levels of test categorisation, including questions that were linguistically and conceptually challenging for foundation students.

Coordinated and unique functions of the E-selectin ligand ESL-1 during inflammatory and hematopoietic recruitment in mice.

PubMed

Sreeramkumar, Vinatha; Leiva, Magdalena; Stadtmann, Anika; Pitaval, Christophe; Ortega-Rodríguez, Inés; Wild, Martin K; Lee, Brendan; Zarbock, Alexander; Hidalgo, Andrés

2013-12-05

Beyond its well-established roles in mediating leukocyte rolling, E-selectin is emerging as a multifunctional receptor capable of inducing integrin activation in neutrophils, and of regulating various biological processes in hematopoietic precursors. Although these effects suggest important homeostatic contributions of this selectin in the immune and hematologic systems, the ligands responsible for transducing these effects in different leukocyte lineages are not well defined. We have characterized mice deficient in E-selectin ligand-1 (ESL-1), or in both P-selectin glycoprotein-1 (PSGL-1) and ESL-1, to explore and compare the contributions of these glycoproteins in immune and hematopoietic cell trafficking. In the steady state, ESL-1 deficiency resulted in a moderate myeloid expansion that became more prominent when both glycoproteins were eliminated. During inflammation, PSGL-1 dominated E-selectin binding, rolling, integrin activation, and extravasation of mature neutrophils, but only the combined deficiency in PSGL-1 and ESL-1 completely abrogated leukocyte recruitment. Surprisingly, we find that the levels of ESL-1 were strongly elevated in hematopoietic progenitor cells. These elevations correlated with a prominent function of ESL-1 for E-selectin binding and for migration of hematopoietic progenitor cells into the bone marrow. Our results uncover dominant roles for ESL-1 in the immature compartment, and a functional shift toward PSGL-1 dependence in mature neutrophils.

Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial.

PubMed

Sperling, Michael R; Abou-Khalil, Bassel; Harvey, Jay; Rogin, Joanne B; Biraben, Arnaud; Galimberti, Carlo A; Kowacs, Pedro A; Hong, Seung Bong; Cheng, Hailong; Blum, David; Nunes, Teresa; Soares-da-Silva, Patrício

2015-02-01

To evaluate the efficacy and safety of adjunctive eslicarbazepine acetate (ESL) in patients with refractory partial-onset seizures. This randomized, placebo-controlled, double-blind, parallel-group, phase III study was conducted at 173 centers in 19 countries, including the United States and Canada. Eligible patients were aged ≥16 years and had uncontrolled partial-onset seizures despite treatment with 1-2 antiepileptic drugs (AEDs). After an 8-week baseline period, patients were randomized to once-daily placebo (n = 226), ESL 800 mg (n = 216), or ESL 1,200 mg (n = 211). Following a 2-week titration period, patients received ESL 800 or 1,200 mg once-daily for 12 weeks. Seizure data were captured and documented using event-entry or daily entry diaries. Standardized seizure frequency (SSF) during the maintenance period (primary end point) was reduced with ESL 1,200 mg (p = 0.004), and there was a trend toward improvement with ESL 800 mg (p = 0.06), compared with placebo. When data for titration and maintenance periods were combined, ESL 800 mg (p = 0.001) and 1,200 mg (p < 0.001) both reduced SSF. There were no statistically significant interactions between treatment response and geographical region (p = 0.38) or diary version (p = 0.76). Responder rate (≥50% reduction in SSF) was significantly higher with ESL 1,200 mg (42.6%, p < 0.001) but not ESL 800 mg (30.5%, p = 0.07) than placebo (23.1%). Incidence of treatment-emergent adverse events (TEAEs) and TEAEs leading to discontinuation increased with ESL dose. The most common TEAEs were dizziness, somnolence, nausea, headache, and diplopia. Adjunctive ESL 1,200 mg once-daily was more efficacious than placebo in adult patients with refractory partial-onset seizures. The once-daily 800 mg dose showed a marginal effect on SSF, but did not reach statistical significance. Both doses were well tolerated. Efficacy assessment was not affected by diary format used. © 2014 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy.

Update on the role of eslicarbazepine acetate in the treatment of partial-onset epilepsy

PubMed Central

Tambucci, Renato; Basti, Claudia; Maresca, Maria; Coppola, Giangennaro; Verrotti, Alberto

2016-01-01

Eslicarbazepine acetate (ESL) is a once daily new third generation antiepileptic drug that shares the basic chemical structure of carbamazepine and oxcarbazepine – a dibenzazepine nucleus with the 5-carboxamide substituent, but is structurally different at the 10,11-position. ESL is a pro-drug metabolized to its major active metabolite eslicarbazepine. Despite the fact that the exact mechanism of action has not been fully elucidated, it is thought to involve inhibition of voltage-gated sodium channels (VGSC). ESL inhibits sodium currents in a voltage-dependent way by an interaction predominantly with the inactivated state of the VGSC, thus selectively reducing the activity of rapidly firing (epileptic) neurons. ESL reduces VGSC availability through enhancement of slow inactivation. In Phase III studies, adjunctive therapy with ESL 800 or 1,200 mg/day leads to a significant decrease in the seizure frequency in adults with refractory partial onset epilepsy. Based on these results, ESL has been approved in Europe (by the European Medicines Agency) and in the United States (by the US Food and Drug Administration) as add-on therapy. Data on efficacy and safety have been confirmed by 1-year extension and real life observational studies. Recently, based on results from two randomized, double-blind, historical control Phase III trials, ESL received US Food and Drug Administration approval also as a monotherapy for patients with partial onset epilepsy. In the pediatric setting, encouraging results have been obtained suggesting its potential role in the management of epileptic children. Overall ESL was generally well tolerated. The most common adverse events were dizziness, somnolence, headache, nausea, diplopia, and vomiting. Adverse events can be minimized by appropriate titration. In conclusion, ESL seems to overcome some drawbacks of the previous antiepileptic drugs, suggesting a major role of ESL in the management of focal onset epilepsy for both new onset and refractory cases, either as monotherapy or as adjunctive treatment. PMID:27307737

Update on the role of eslicarbazepine acetate in the treatment of partial-onset epilepsy.

PubMed

Tambucci, Renato; Basti, Claudia; Maresca, Maria; Coppola, Giangennaro; Verrotti, Alberto

2016-01-01

Eslicarbazepine acetate (ESL) is a once daily new third generation antiepileptic drug that shares the basic chemical structure of carbamazepine and oxcarbazepine - a dibenzazepine nucleus with the 5-carboxamide substituent, but is structurally different at the 10,11-position. ESL is a pro-drug metabolized to its major active metabolite eslicarbazepine. Despite the fact that the exact mechanism of action has not been fully elucidated, it is thought to involve inhibition of voltage-gated sodium channels (VGSC). ESL inhibits sodium currents in a voltage-dependent way by an interaction predominantly with the inactivated state of the VGSC, thus selectively reducing the activity of rapidly firing (epileptic) neurons. ESL reduces VGSC availability through enhancement of slow inactivation. In Phase III studies, adjunctive therapy with ESL 800 or 1,200 mg/day leads to a significant decrease in the seizure frequency in adults with refractory partial onset epilepsy. Based on these results, ESL has been approved in Europe (by the European Medicines Agency) and in the United States (by the US Food and Drug Administration) as add-on therapy. Data on efficacy and safety have been confirmed by 1-year extension and real life observational studies. Recently, based on results from two randomized, double-blind, historical control Phase III trials, ESL received US Food and Drug Administration approval also as a monotherapy for patients with partial onset epilepsy. In the pediatric setting, encouraging results have been obtained suggesting its potential role in the management of epileptic children. Overall ESL was generally well tolerated. The most common adverse events were dizziness, somnolence, headache, nausea, diplopia, and vomiting. Adverse events can be minimized by appropriate titration. In conclusion, ESL seems to overcome some drawbacks of the previous antiepileptic drugs, suggesting a major role of ESL in the management of focal onset epilepsy for both new onset and refractory cases, either as monotherapy or as adjunctive treatment.

Development of an ESL curriculum to educate Chinese immigrants about hepatitis B.

PubMed

Taylor, Victoria M; Coronado, Gloria; Acorda, Elizabeth; Teh, Chong; Tu, Shin-Ping; Yasui, Yutaka; Bastani, Roshan; Hislop, T Gregory

2008-08-01

Chinese immigrants to North America have substantially higher rates of chronic hepatitis B infection than the general population. One area for strategic development in the field of health education is the design and evaluation of English-as-a-Second language (ESL) curricula. The theoretical perspective of the Health Behavior Framework, results from a community-based survey of Chinese Canadian immigrants with limited English proficiency, and findings from focus groups of ESL instructors as well as Chinese ESL students were used to develop a hepatitis B ESL educational module. This research was conducted in Vancouver, BC. Survey data showed that less than three-fifths of the respondents had been tested for hepatitis B, and documented some important hepatitis B knowledge deficits. Further, only about one-quarter had ever received a physician recommendation for hepatitis B serologic testing. The ESL curriculum aims to both promote hepatitis B testing and improve knowledge, and includes seven different ESL exercises: Warm-up, vocabulary cards, information-gap, video, jigsaw, guided discussion, and problem/advice cards. Our quantitative and qualitative methods for curriculum development could be replicated for other health education topics and in other limited English speaking populations.

Proficiency in English sentence stress production by Cantonese speakers who speak English as a second language (ESL).

PubMed

Ng, Manwa L; Chen, Yang

2011-12-01

The present study examined English sentence stress produced by native Cantonese speakers who were speaking English as a second language (ESL). Cantonese ESL speakers' proficiency in English stress production as perceived by English-speaking listeners was also studied. Acoustical parameters associated with sentence stress including fundamental frequency (F0), vowel duration, and intensity were measured from the English sentences produced by 40 Cantonese ESL speakers. Data were compared with those obtained from 40 native speakers of American English. The speech samples were also judged by eight native listeners who were native speakers of American English for placement, degree, and naturalness of stress. Results showed that Cantonese ESL speakers were able to use F0, vowel duration, and intensity to differentiate sentence stress patterns. Yet, both female and male Cantonese ESL speakers exhibited consistently higher F0 in stressed words than English speakers. Overall, Cantonese ESL speakers were found to be proficient in using duration and intensity to signal sentence stress, in a way comparable with English speakers. In addition, F0 and intensity were found to correlate closely with perceptual judgement and the degree of stress with the naturalness of stress.

Effects of Environmental Oxygen Content and Dissolved Oxygen on the Surface Tension and Viscosity of Liquid Nickel

NASA Astrophysics Data System (ADS)

SanSoucie, M. P.; Rogers, J. R.; Kumar, V.; Rodriguez, J.; Xiao, X.; Matson, D. M.

2016-07-01

The NASA Marshall Space Flight Center's electrostatic levitation (ESL) laboratory has recently added an oxygen partial pressure controller. This system allows the oxygen partial pressure within the vacuum chamber to be measured and controlled in the range from approximately 10^{-28} {to} 10^{-9} bar, while in a vacuum atmosphere. The oxygen control system installed in the ESL laboratory's main chamber consists of an oxygen sensor, oxygen pump, and a control unit. The sensor is a potentiometric device that determines the difference in oxygen activity in two gas compartments (inside the chamber and the air outside of the chamber) separated by an electrolyte. The pump utilizes coulometric titration to either add or remove oxygen. The system is controlled by a desktop control unit, which can also be accessed via a computer. The controller performs temperature control for the sensor and pump, has a PID-based current loop and a control algorithm. Oxygen partial pressure has been shown to play a significant role in the surface tension of liquid metals. Oxide films or dissolved oxygen may lead to significant changes in surface tension. The effects on surface tension and viscosity by oxygen partial pressure in the surrounding environment and the melt dissolved oxygen content will be evaluated, and the results will be presented. The surface tension and viscosity will be measured at several different oxygen partial pressures while the sample is undercooled. Surface tension and viscosity will be measured using the oscillating droplet method.

Abuse liability assessment of eslicarbazepine acetate in healthy male and female recreational sedative users: A Phase I randomized controlled trial.

PubMed

Levy-Cooperman, Naama; Schoedel, Kerri A; Chakraborty, Bijan; Blum, David; Cheng, Hailong

2016-08-01

Eslicarbazepine acetate (ESL) is a once-daily oral antiepileptic drug for the treatment of partial-onset seizures. Adverse events such as dizziness and somnolence reported in clinical studies suggest that ESL has detectable central nervous system (CNS) effects in addition to its antiepileptic effects. This Phase I study evaluated the abuse liability of ESL compared with that of alprazolam (ALP) and placebo (PBO) in recreational CNS depressant users. In this single-dose, randomized, double-blind, PBO- and active-controlled crossover study, healthy recreational CNS depressant users who could discern between ALP 2mg and PBO received single oral doses of each of the following treatments with a washout interval of ≥7days between each treatment: ESL (800mg, 1600mg, 2000mg, and 2400mg); ALP (1.5mg and 3.0mg); and PBO. Subjective measures, including visual analog scales (VASs) e.g., Drug-Liking (primary endpoint), and Addiction Research Center Inventory (ARCI) Morphine-Benzedrine Group (MBG), Pentobarbital Chlorpromazine Alcohol Group (PCAG), and Lysergic Acid Diethylamide Group scales were evaluated at multiple time points up to 24h postdose. Cognitive effects were evaluated using the Choice Reaction Time (CRT), Divided Attention (DAT) and Hopkins Verbal Learning Task-Revised tests. Peak scores for Drug-Liking VAS (maximum effect [Emax]) were significantly higher for both ALP doses than for PBO (p<0.0001), thereby confirming study validity. Drug-Liking VAS Emax was significantly lower for all ESL doses than both ALP doses (p<0.0001). Drug-Liking VAS Emax for ESL 800mg was similar to that for PBO (least squares [LS] mean difference: 3.6; p=0.19). At the three higher ESL doses (1600mg and the supratherapeutic doses of 2000mg and 2400mg), Drug-Liking VAS Emax was significantly higher than for PBO, although the differences were minimal (LS mean difference: 9.3-13.3 out of 100). For most secondary subjective endpoints (i.e., Good Effects VAS and High VAS, ARCI-MBG, Take Drug Again VAS, Overall Drug-Liking VAS, and ARCI-PCAG; p<0.05), the effect of ESL (all doses) was significantly less than that of ALP (both doses). On most secondary measures, the dose-response relationship was relatively flat or showed saturation at higher ESL doses. Although significant differences were observed for ESL compared with those for PBO for some specific CRT and DAT endpoints (i.e., reaction time, manual tracking, hit latency), ALP demonstrated significant and dose-dependent impairment on the majority of cognitive endpoints when compared with PBO and ESL. Mean plasma concentrations of the active metabolite of ESL, eslicarbazepine, increased with increasing ESL dose. Pharmacokinetic parameters estimated for eslicarbazepine were generally comparable with results from previous studies in healthy volunteers. This study demonstrated that single doses of ESL may have less abuse liability than ALP in recreational sedative users. Although ESL had detectable subjective effects and showed some drug-'liking' at higher doses, the magnitude of these effects was small. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Collaboration Model for ESL and Content Teachers

ERIC Educational Resources Information Center

Broer, Kathleen

2013-01-01

This study will examine strategies that ESL teachers and content teachers can use to help middle school ESL students acquire science vocabulary and meta-cognitive strategies for writing skills in non-fiction text forms. Two appendixes are included. (Contains 3 figures and 2 footnotes.)

American Language Review, 2001.

ERIC Educational Resources Information Center

Ward, Ben, Ed.

2001-01-01

These eight journals include articles on such topics as the following: adult literacy; incorporating song lyrics and music into the English-as-a-Second-Language (ESL) classroom; using poetry with adult ESL learners; reading "Time" and "Newsweek" in ESL classrooms; teaching intuitively; teacher-created materials; New England…

Extending Depot Length and Intervals for DDG 51 Class Ships: Examining the 72 Month Operational Cycle

DTIC Science & Technology

2016-01-01

tenance period to achieve planned expected service life ( ESL ), as well as the length, workload, and periodicity of a continuous maintenance...a ship’s service life but extends the length of each deployment. Figure 2.1 compares the number of deployments that can be made over the ESL of...ships in different cycle lengths. The ESL of DDG-51 Arleigh Burke–class destroyers Flight I and II is 35 years, and Flight IIA has an ESL of 40 years

The Efficacy of Eslicarbazepine Acetate in Models of Trigeminal, Neuropathic, and Visceral Pain: The Involvement of 5-HT1B/1D Serotonergic and CB1/CB2 Cannabinoid Receptors.

PubMed

Tomić, Maja A; Pecikoza, Uroš B; Micov, Ana M; Stepanović-Petrović, Radica M

2015-12-01

Many clinical pain states that are difficult to treat share a common feature of sensitization of nociceptive pathways. Drugs that could normalize hyperexcitable neural activity (e.g., antiepileptic drugs) may be useful in relieving these pain states. Eslicarbazepine acetate (ESL) is a novel antiepileptic drug derived from carbamazepine/oxcarbazepine with a more favorable metabolic profile and potentially better tolerability. We examined the efficacy of ESL in models of inflammatory and neuropathic pain and the potential mechanism involved in its action. The antinociceptive effects of ESL were assessed in mice models of trigeminal (orofacial formalin test), neuropathic (streptozotocin-induced diabetic neuropathy model), and visceral pain (writhing test). The influence of 5-HT1B/1D serotonin receptor (GR 127935) and CB1 (AM251) and CB2 cannabinoid receptor (AM630) antagonists on the antinociceptive effect of ESL was tested in the model of trigeminal pain. ESL exhibited significant and dose-dependent antinociceptive effects in the second phase of the orofacial formalin test (P ≤ 0.011), in the tail-flick test in diabetic mice (P ≤ 0.013), and in the writhing test (P ≤ 0.003). GR 127935 (P ≤ 0.038) and AM251 and AM630 (P ≤ 0.013 for both antagonists) significantly inhibited the antinociceptive effect of ESL in a dose-related manner. ESL exhibited efficacy in models of trigeminal, neuropathic, and visceral pain. In the trigeminal pain model, the antinociceptive effect of ESL is, at least in part, mediated by 5-HT1B/1D serotonin and CB1/CB2 cannabinoid receptors. This study indicates that ESL could be useful in the clinical treatment of inflammatory and neuropathic pain.

A common reference-based indirect comparison meta-analysis of eslicarbazepine versus lacosamide as add on treatments for focal epilepsy.

PubMed

Brigo, Francesco; Trinka, Eugen; Bragazzi, Nicola Luigi; Nardone, Raffaele; Milan, Alberto; Grillo, Elisabetta

2016-11-01

Eslicarbazepine acetate (ESL) and lacosamide (LCM) have recently emerged as add-on treatments in patients with focal epilepsy experiencing seizures despite adequate monotherapy. Both drugs enhance slow inactivation of voltage-gated sodium channels. To date no randomized controlled trial (RCT) has directly compared ESL with LCM as add-on treatments for focal epilepsy. Our aim was to indirectly compare the efficacy of ESL and LCM used as add-on treatments in patients with focal epilepsy using common reference-based indirect comparison meta-analysis. We systematically searched RCTs in which ESL or LCM has been used as add-on treatment in patients with focal epilepsy and compared with placebo. Following outcomes were considered: ≥50% reduction in seizure frequency; seizure freedom; treatment withdrawal for any reason; ≥25% increase in seizure frequency. Random-effects Mantel-Haenszel meta-analyses were performed to obtain odds ratios (ORs) for the efficacy of ESL or LCM versus placebo. Adjusted indirect comparisons were then made between ESL and LCM using the obtained results, and comparing the minimum and the highest effective recommended daily dose of each drug. Eight studies were included. Indirect comparisons adjusted for dose-effect showed no difference between ESL and LCM for responder rate, seizure freedom, and withdrawal rates. We could not assess increase in seizure frequency due to lack of data. Indirect comparisons failed to find a significant difference in efficacy between add-on ESL and LCM in patients with focal epilepsy. Direct head-to-head clinical trials comparing ESL with LCM as add-on antiepileptic treatment are required to confirm these results. Copyright © 2016 Elsevier B.V. All rights reserved.

Conversion to eslicarbazepine acetate monotherapy

PubMed Central

French, Jacqueline; Jacobson, Mercedes P.; Pazdera, Ladislav; Gough, Mallory; Cheng, Hailong; Grinnell, Todd; Blum, David

2016-01-01

Objective: To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy. Methods: This post hoc pooled analysis of 2 randomized double-blind studies (093-045 and -046) included adults with partial-onset seizures medically uncontrolled by 1 or 2 antiepileptic drugs (AEDs). Following the baseline period (8 weeks), eligible patients were randomized 2:1 to receive ESL 1,600 mg or 1,200 mg once daily for 18 weeks; the primary endpoint was study exit by meeting predefined exit criteria (signifying worsening seizure control). In each study, treatment was considered effective if the upper 95% confidence limit for exit rate was lower than the historical control threshold (65.3%). Results: Pooled exit rates were as follows: ESL 1,600 mg = 20.6% (95% confidence interval: 15.6%–26.8%); ESL 1,200 mg = 30.8% (23.0%–40.5%). Use of 2 baseline AEDs or rescue medication, US location, epilepsy duration ≥20 years, and higher maximum baseline seizure frequency were associated with higher exit risks. Median percent reductions in standardized seizure frequency between baseline and the 18-week double-blind period were as follows: ESL 1,600 mg = 43.2%; ESL 1,200 mg = 35.7%; baseline carbamazepine use was associated with smaller reductions. Safety profiles were similar between ESL doses. Conclusions: Exit rates for ESL monotherapy (1,600 mg and 1,200 mg once daily) were lower than the historical control threshold, irrespective of baseline AED use and region, with no additional safety concerns identified. Clinical factors and location clearly influence treatment responses in conversion-to-monotherapy trials. Classification of evidence: This pooled analysis provides Class IV evidence that for adults with medically uncontrolled partial-onset seizures, ESL monotherapy is well tolerated and effective. PMID:26911639

Conversion to eslicarbazepine acetate monotherapy: A pooled analysis of 2 phase III studies.

PubMed

Sperling, Michael R; French, Jacqueline; Jacobson, Mercedes P; Pazdera, Ladislav; Gough, Mallory; Cheng, Hailong; Grinnell, Todd; Blum, David

2016-03-22

To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy. This post hoc pooled analysis of 2 randomized double-blind studies (093-045 and -046) included adults with partial-onset seizures medically uncontrolled by 1 or 2 antiepileptic drugs (AEDs). Following the baseline period (8 weeks), eligible patients were randomized 2:1 to receive ESL 1,600 mg or 1,200 mg once daily for 18 weeks; the primary endpoint was study exit by meeting predefined exit criteria (signifying worsening seizure control). In each study, treatment was considered effective if the upper 95% confidence limit for exit rate was lower than the historical control threshold (65.3%). Pooled exit rates were as follows: ESL 1,600 mg = 20.6% (95% confidence interval: 15.6%-26.8%); ESL 1,200 mg = 30.8% (23.0%-40.5%). Use of 2 baseline AEDs or rescue medication, US location, epilepsy duration ≥20 years, and higher maximum baseline seizure frequency were associated with higher exit risks. Median percent reductions in standardized seizure frequency between baseline and the 18-week double-blind period were as follows: ESL 1,600 mg = 43.2%; ESL 1,200 mg = 35.7%; baseline carbamazepine use was associated with smaller reductions. Safety profiles were similar between ESL doses. Exit rates for ESL monotherapy (1,600 mg and 1,200 mg once daily) were lower than the historical control threshold, irrespective of baseline AED use and region, with no additional safety concerns identified. Clinical factors and location clearly influence treatment responses in conversion-to-monotherapy trials. This pooled analysis provides Class IV evidence that for adults with medically uncontrolled partial-onset seizures, ESL monotherapy is well tolerated and effective. © 2016 American Academy of Neurology.

CTC-Endothelial Cell Interactions during Metastasis

DTIC Science & Technology

2013-04-01

endothelial cells via a variety of E-selectin ligands ( ESL ). These ESLs express a unique carbohydrate motif, sLex, which appears to be required for... ESL binding. The chemokine receptor CXCR4 has also been reported to supporting transendothelial migration of prostate cells through bone marrow

Complexity and Community: Finding What Works in Workplace ESL

ERIC Educational Resources Information Center

Brooks, Ann K.

2009-01-01

This chapter addresses the complexity of providing workplace ESL by identifying patterns of "best practices" in the related fields of human resource management, adult education, and training and development, all of which have a stake in workplace ESL and the integration of immigrant workers.

Lexical Exploration for Advanced ESL Students in Public Health.

ERIC Educational Resources Information Center

Wakai, Helen K.

This paper develops guidelines for instructional materials for advanced English as a second language students in which the objects of instruction would be: (1) the relationship between surface structures of lexical items and their underlying meanings; (2) the important aspects of structural forms; and (3) the special uses of words in the lexicon…

Eslicarbazepine acetate exposure in pregnant women with epilepsy.

PubMed

Costa, Raquel; Magalhães, Luís M; Graça, Joana; Vieira, Mariana; Gama, Helena; Moreira, Joana; Rocha, José F; Soares-da-Silva, Patrício

2018-05-01

Epilepsy is a common neurologic disorder requiring continued treatment during pregnancy. Treatment with antiepileptic drugs (AEDs) is needed for seizure control, but the risk of adverse events has to be minimized for both mother and foetus. Available data on pregnancy and foetal/postnatal outcomes following eslicarbazepine acetate (ESL) exposure via parent is herein presented for the first time. ESL's global safety database was reviewed to identify pregnancy cases with exposure to ESL reported up to October 21st, 2017. The EMBASE™ and MEDLINE ® databases were searched to identify literature reports of such cases published between May 1st, 2009 and October 21st, 2017. Overall, 91 notifications of pregnancy were identified, of which 79 involved ESL exposure: 28 during clinical trials and 51 from 8-years of post-marketing surveillance. Thirty pregnancies resulted in live birth without congenital anomalies; in 25 pregnancies the outcome was ongoing and 3 was unknown; 18 cases resulted in abortion (10 spontaneous and 8 induced) and congenital anomalies were identified in 5 cases (no clear relationship with ESL was established). ESL was used concomitantly to other AEDs in 11 of the 15 pregnancies for which the outcome was spontaneous abortion and congenital anomaly. Literature review did not yield additional information. Available data are insufficient to draw conclusions regarding ESL use during pregnancy. Although no particular safety problem was identified, ESL exposure during pregnancy will continue to be monitored and evaluated. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamamoto, Hiroyasu; Kuroda, Nana; Uekita, Hiromi

Background: Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. Methods and Results: In this study, we identified E-selectin ligand (ESL)-1 as a novel APN-binding protein by mass spectrometry analysis of HepG2 cell-derived immunoprecipitant with an anti-APN antibody. Cell adhesion assays using fluorescence-labelled monocyte cell line THP-1 cells and human umbilical vein endothelial cells (HUVECs) revealed that APN-pre-treated THP-1 cells had reduced binding ability to HUVECs. This APN-mediated suppressive effect on monocyte binding to endothelial cells was partiallymore » abrogated by targeting ESL-1 with shRNA in THP-1 cells. In addition, serial mutagenesis analysis disclosed that five extracellular amino acids close to the N-terminus of ESL-1 were essential for binding with APN. Conclusion: Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. - Highlights: • E-selectin ligand (ESL)-1 was identified as an adiponectin (APN)-binding protein. • ESL-1 bound to APN at its N-terminal 6th-10th amino acids. • shESL-1 reduced the suppressive effect of APN on adhesion of THP-1 cells to HUVECs. • Interaction with ESL may be involved in the anti-atherogenic effects of APN.« less

Adult ESL Education in the US

ERIC Educational Resources Information Center

Eyring, Janet L.

2014-01-01

This article discusses the state of the art in the field of "adult ESL" in the US. It identifies the size, characteristics, and settings of adult education and discusses relevant professional standards, assessment procedures, and teacher preparation. Three approaches to noncredit adult ESL education will be presented (Functional…

Computer Simulation and ESL Reading.

ERIC Educational Resources Information Center

Wu, Mary A.

It is noted that although two approaches to second language instruction--the communicative approach emphasizing genuine language use and computer assisted instruction--have come together in the form of some lower level reading instruction materials for English as a second language (ESL), advanced level ESL reading materials using computer…

Promoting Discussions in ESL Students

ERIC Educational Resources Information Center

Navarro, Ann

2010-01-01

Background: Teachers who work with English as a Second Language (ESL) students, struggle with promoting discussion during guided reading. When ESL students are asked comprehension questions during group discussions and throughout the reading of a book, often teachers receive minimal feedback. Purpose: The purpose of this research is to identify…

Noncontact technique for measuring the electrical resistivity and magnetic susceptibility of electrostatically levitated melts

NASA Astrophysics Data System (ADS)

Rustan, G. E.; Spyrison, N. S.; Kreyssig, A.; Prozorov, R.; Goldman, A. I.

2012-02-01

Over the last two decades the popularity of levitation methods for studying equilibrium and supercooled melts has increased steadily. Measurements of density, viscosity, surface tension, and atomic structure have become well established. In contrast, measurements of electrical resistivity and magnetic susceptibility of levitated melts have been very limited. To fill this void, we have combined the tunnel diode oscillator (TDO) technique with electrostatic levitation (ESL) to perform inductively coupled measurements on levitated melts. A description of the basic operating principles of the TDO and ESL will be given, as well as a description of the implementation and performance characteristics of this technique. Preliminary measurements of electrical resistivity in the solid and liquid state will be presented for samples of Zr, Si, and Ge, as well as the measurements of ferromagnetic transitions in Fe and Co based alloys.

Effects of Oxygen Partial Pressure on the Surface Tension of Liquid Nickel

NASA Technical Reports Server (NTRS)

SanSoucie, Michael P.; Rogers, Jan R.; Gowda, Vijaya Kumar Malahalli Shankare; Rodriguez, Justin; Matson, Douglas M.

2015-01-01

The NASA Marshall Space Flight Center's electrostatic levitation (ESL) laboratory has been recently upgraded with an oxygen partial pressure controller. This system allows the oxygen partial pressure within the vacuum chamber to be measured and controlled, theoretically in the range from 10-36 to 100 bar. The oxygen control system installed in the ESL laboratory's main chamber consists of an oxygen sensor, oxygen pump, and a control unit. The sensor is a potentiometric device that determines the difference in oxygen activity in two gas compartments (inside the chamber and the air outside of the chamber) separated by an electrolyte, which is yttria-stabilized zirconia. The pump utilizes coulometric titration to either add or remove oxygen. The system is controlled by a desktop control unit, which can also be accessed via a computer. The controller performs temperature control for the sensor and pump, PID-based current loop, and a control algorithm. Oxygen partial pressure has been shown to play a significant role in the surface tension of liquid metals. Oxide films or dissolved oxygen may lead to significant changes in surface tension. The effects of oxygen partial pressure on the surface tension of undercooled liquid nickel will be analyzed, and the results will be presented. The surface tension will be measured at several different oxygen partial pressures while the sample is undercooled. Surface tension will be measured using the oscillating drop method. While undercooled, each sample will be oscillated several times consecutively to investigate how the surface tension behaves with time while at a particular oxygen partial pressure.

Balancing Act: Addressing Culture and Gender in ESL Classrooms

ERIC Educational Resources Information Center

Johnson, Michelle A.; Chang, Debbie

2012-01-01

ESL educators find themselves teaching a diverse group of students in today's classroom. This study investigated how ESL instructors address diversity in their teaching. The literature review revealed research on the experiences of teachers using culturally responsive teaching strategies. Using qualitative research methods, this study explores the…

Let's Talk! ESL Students' Needs and Writing Centre Philosophy

ERIC Educational Resources Information Center

Moussu, Lucie

2013-01-01

When university/college faculty members believe that ESL students' writing skills are not equivalent to those of native speakers, they frequently send these ESL students to their institution's writing centres (WCs). However, this often results in frustration for WC staff, the students, and faculty members. This article first describes ESL…

28 CFR 544.42 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Mandatory English-as-a-Second Language Program (ESL) § 544.42 Procedures. (a) The Warden at each federal... proficient are enrolled in the ESL program. Determination of limited English proficiency is made by staff on... demonstrate verified achievement of the eighth grade level, must provide verification or enroll in the ESL...

Translating Information Literacy: Online Library Support for ESL Students

ERIC Educational Resources Information Center

Lombard, Emmett

2016-01-01

This article describes information literacy struggles of ESL college students within the context of four information literacy components: Identify, Locate, Evaluate, Use. Experiences from an online freshman composition course are used to illustrate these struggles, along with techniques academic librarians use to help ESL students from a distance.

Language Minority Student Transitions

ERIC Educational Resources Information Center

Suh, Emily

2016-01-01

Unfortunately, the journey to college can be lengthy for immigrants who must demonstrate English proficiency by completing a series of ESL classes while balancing work, family, and school (Blumenthal, 2002). At Southeast Community College (SCC), in Lincoln, Nebraska, the sequence ranges from classes in Beginning ESL to ESL for Academic Success,…

ESL Learners' Online Research and Comprehension Strategies

ERIC Educational Resources Information Center

Sain, Noridah; Bown, Andy; Fluck, Andrew; Kebble, Paul

2017-01-01

In order to enhance second language (L2) acquisition, English as a Second Language (ESL) students are encouraged to exploit the abundant information and opportunities for authentic language use afforded by the Internet. This study investigated the online research and comprehension strategies employed by ESL learners in a public university in…

Teaching Freshman History to ESL Students: A Model.

ERIC Educational Resources Information Center

Carro, Gladys

This paper describes the evolution and implementation of an interdisciplinary freshman program in world civilization designed to integrate history content with advanced English-as-a-Second-Language (ESL) composition, focusing on academic language use. In it, a three-credit history course is paired with a six-credit ESL composition course. The…

Setting up an Adult ESL Program in the Fiji Islands.

ERIC Educational Resources Information Center

Thorkelson, Myra

1987-01-01

The author describes an English as a Second Language (ESL) course she taught in Fiji (where English is the official language of commerce and government) for adult speakers of a Hindi dialect or Fijian. She discusses evaluation of student needs and specific exercises for adult ESL classes. (CH)

Accuracy vs. Fluency: Which Comes First in ESL Instruction?

ERIC Educational Resources Information Center

Ebsworth, Miriam Eisenstein

1998-01-01

Discusses the debate over fluency versus accuracy in teaching English-as-a-Second-Language (ESL). Defines fluency and accuracy; examines alternative approaches (meaning first, accuracy first, and accuracy and fluency from the beginning); evaluates the alternatives; and highlights implications for teaching ESL. A sidebar presents an accuracy and…

Teaching Techniques for the ESL Literacy Classroom. [Videotape.

ERIC Educational Resources Information Center

Gati, Sally

This 71-minute videotape presents a three-part program of classroom teaching techniques for teachers of English-as-a-Second-Language (ESL) literacy students. It shows students interacting with ESL literacy teachers, and focuses on: (1) essential teaching tools (chalkboard, easel, overhead projector, butcher paper, realia, pictures, flash cards,…

Conceptualizing Learning Style Modalities for ESL/EFL Students.

ERIC Educational Resources Information Center

Wintergerst, Ann C.; DeCapua, Andrea; Verna, Marilyn Ann

2003-01-01

Reports results of testing a newly developed learning styles instrument on three groups of language learners: Russian English-as-a-Foreign-Language students, Russian English-as-a-Second-Language (ESL) students, and Asian ESL students to determine their learning style preference. Results indicate that these students learn English under three…

Ouch! Or ESL and the Glass Ceiling.

ERIC Educational Resources Information Center

Migliacci, Naomi

The realities of the glass ceiling, which prevents qualified women, minorities, and many English-as-a-Second-Language (ESL) students from advancement and promotion, are rarely discussed in English for Special Purposes (ESP)/ESL programs and courses. This paper explores the barriers to success, focusing on the sociolinguistic factors of verbal and…

Professionalization and Exclusion in ESL Teaching

ERIC Educational Resources Information Center

Breshears, Sherry

2004-01-01

As ESL/EFL teachers, how do we fit into the spectrum between unskilled workers and highly trained professionals? This article examines three features of the traditional professions and applies them to the ESL/EFL context. It considers problems with the lack of mandatory standardized certification, critically assesses attachment to the university,…

Flipped ESL Teacher Professional Development: Embracing Change to Remain Relevant

ERIC Educational Resources Information Center

Razak, Rafiza Abdul; Kaur, Dalwinder; Halili, Siti Hajar; Ramlan, Zahri

2016-01-01

Many traditional professional development programs that are initiated to equip ESL teachers with knowledge and skills have been futile for numerous reasons. This paper addresses a gap in the recent research of ESL teachers' professional development. Literature has revealed many shortcomings of the traditional and online professional development…

Adult ESL: Politics, Pedagogy, and Participation in Classroom and Community Programs.

ERIC Educational Resources Information Center

Smoke, Trudy, Ed.

The collection of essays on the politics of adult English-as-a-Second-Language (ESL) instruction includes: "The Politics of Adult ESL literacy: Becoming Politically Visible" (Pamela Ferguson); "Learning To Be Legal: Unintended Meanings for Adult Schools" (Pia Moriarty); "The Relationship Between Knowing Our Students' Real…

Unspoken Content: Silent Film in the ESL Classroom.

ERIC Educational Resources Information Center

Kasper, Loretta F.; Singer, Robert

2001-01-01

Describes how one short silent film, "The Painted Lady," may be used to build language and content knowledge in English-as-a-second-language (ESL) courses. Provides a representative list of titles and corresponding content areas to assist instructors in their efforts to incorporate silent film into ESL courses. (SG)

Prisoners Teaching ESL: A Learning Community among "Language Partners"

ERIC Educational Resources Information Center

Olinger, Andrea; Bishop, Hugh; Cabrales, Jose; Ginsburg, Rebecca; Mapp, Joseph; Mayorga, Orlando; Nava, Erick; Nunez, Elfego; Rosas, Otilio; Slater, Andre; Sorenson, LuAnn; Sosnowski, Jim; Torres, Agustin

2012-01-01

This article features Language Partners, an ESL program offered at the Danville Correctional Center, a medium-security men's prison in central Illinois. The program in which prisoners teach ESL classes, supported by volunteer teacher-trainers, is a learning community with immense and sometimes unforeseen value. The authors discuss reasons for…

Teaching English in the Workplace.

ERIC Educational Resources Information Center

Belfiore, Mary Ellen; Burnaby, Barbara

A guide to program planning and administration of instruction in EWP (English as a second language (ESL) in the workplace combined with varying degrees of general ESL/orientation information) is intended for management and union representatives, EWP coordinators, and ESL administrators as well as teachers. Its primary purposes are to bring…

A History of ESL Instruction in Madison, Wisconsin.

ERIC Educational Resources Information Center

Kuntz, Patricia S.

This paper investigates the emergence of English-as-a- Second-Language (ESL) instruction in Madison, Wisconsin. Like other medium-sized, upper-midwest communities, the demand for ESL instruction has exploded. Despite some visa limitations placed on international students who wish to study English in the United States since September 2001, ESL…

English Nominal Compounds and the ESL/EFL Reader.

ERIC Educational Resources Information Center

Olshtain, Elite

The interpretation of nonlexicalized compound words in English by speakers of English as a second language (ESL) was investigated. Three types of competence used in interpreting noun compounds are identified: pragmatic, linguistic, and textual. The use of these three types of competence by Hebrew speaking college students enrolled in ESL reading…

ESL Students' Computer-Mediated Communication Practices: Context Configuration

ERIC Educational Resources Information Center

Shin, Dong-Shin

2006-01-01

This paper examines how context is configured in ESL students' language learning practices through computer-mediated communication (CMC). Specifically, I focus on how a group of ESL students jointly constructed the context of their CMC activities through interactional patterns and norms, and how configured affordances within the CMC environment…

Ethical Issues in Addressing Inequity in/through ESL Research

ERIC Educational Resources Information Center

Lee, Ena

2011-01-01

This article outlines a researcher's struggles with conducting "ethical" research when her case study reveals racializations faced by a minority teacher in a Canadian ESL program. How might becoming privy to research participants' experiences of inequity in ESL education complicate the notion of research ethics when "doing the right…

Sensitizing ESL Learners to Genre

ERIC Educational Resources Information Center

Swami, Jasti Appa

2008-01-01

This article evaluates the efficacy of explicit genre-based instruction by sensitizing the ESL learners to the concept of genre. The main questions addressed are: How does sensitizing ESL learners to the rhetorical move structure of a genre, the communicative purposes of these moves, and linguistic features that realize these moves help them to…

Relevant ESL for the Teenager.

ERIC Educational Resources Information Center

Wheatley, Iris Alicia Velez

This guide was prepared for the ESL teacher to help bilingual students learn the English reading and writing skills necessary to acquire a summer job. These lessons are relevant to students' needs, an important factor in generating interest and motivation. General objectives are: to design a relevant ESL program for teenagers; to help monolingual…

Immigrant Success Stories in ESL Textbooks

ERIC Educational Resources Information Center

Gulliver, Trevor

2010-01-01

Immigrant success stories found in English as a second language (ESL) textbooks used in government-funded language instruction in Canada imagine Canada as a redeemer of immigrant newcomers. Through a critical discourse analysis of ESL textbooks used in Language Instruction for Newcomers to Canada classes in Ontario, I identify two primary…

Testing ESL Learners' Knowledge of Collocations.

ERIC Educational Resources Information Center

Bonk, William J.

This study reports on the development, administration, and analysis of a test of collocational knowledge for English-as-a-Second-Language (ESL) learners of a wide range of proficiency levels. Through native speaker item validation and pilot testing, three subtests were developed and administered to 98 ESL learners of low-intermediate to advanced…

Tape It Yourself: Videotapes for Teacher Education

ERIC Educational Resources Information Center

Ebsworth, Miriam Eistein; Feknous, Barbara; Loyet, Dianne; Zimmerman, Spencer

2004-01-01

This paper describes the development and implementation of a series of videotapes of ESL classes for a pre-service teacher education program grounded in experiential learning theory. The videos included footage of ESL classrooms, and tapes edited and supplemented with interviews of ESL teachers. Our experience demonstrates that-with relatively low…

Challenges of recruiting ESL immigrants into cancer education studies: reflections from practice notes.

PubMed

Thomson, Maria D; Hoffman-Goetz, Laurie

2011-03-01

Changing population demographics and immigration patterns have resulted in increasing numbers of Canadians who report speaking a language other than French or English. Inclusion of English-as-a-second-language (ESL) immigrants in cancer education research is critical if disparities in access and use of preventive health care services are to be addressed. This article describes the challenges experienced recruiting and interviewing older ESL immigrant women for a colon cancer prevention study. Factors influencing the recruitment and interview of ESL immigrant women were identified through regular team meetings, interviews, and reflective practice notes. Issues included the importance of community contacts, language barriers, and the motivations of the women for participating. Recommendations for recruitment and inclusion of ESL immigrants in cancer education research are provided.

Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial

PubMed Central

Sperling, Michael R; Abou-Khalil, Bassel; Harvey, Jay; Rogin, Joanne B; Biraben, Arnaud; Galimberti, Carlo A; Kowacs, Pedro A; Hong, Seung Bong; Cheng, Hailong; Blum, David; Nunes, Teresa; Soares-da-Silva, Patrício

2015-01-01

Objective To evaluate the efficacy and safety of adjunctive eslicarbazepine acetate (ESL) in patients with refractory partial-onset seizures. Methods This randomized, placebo-controlled, double-blind, parallel-group, phase III study was conducted at 173 centers in 19 countries, including the United States and Canada. Eligible patients were aged ≥16 years and had uncontrolled partial-onset seizures despite treatment with 1–2 antiepileptic drugs (AEDs). After an 8-week baseline period, patients were randomized to once-daily placebo (n = 226), ESL 800 mg (n = 216), or ESL 1,200 mg (n = 211). Following a 2-week titration period, patients received ESL 800 or 1,200 mg once-daily for 12 weeks. Seizure data were captured and documented using event-entry or daily entry diaries. Results Standardized seizure frequency (SSF) during the maintenance period (primary end point) was reduced with ESL 1,200 mg (p = 0.004), and there was a trend toward improvement with ESL 800 mg (p = 0.06), compared with placebo. When data for titration and maintenance periods were combined, ESL 800 mg (p = 0.001) and 1,200 mg (p < 0.001) both reduced SSF. There were no statistically significant interactions between treatment response and geographical region (p = 0.38) or diary version (p = 0.76). Responder rate (≥50% reduction in SSF) was significantly higher with ESL 1,200 mg (42.6%, p < 0.001) but not ESL 800 mg (30.5%, p = 0.07) than placebo (23.1%). Incidence of treatment-emergent adverse events (TEAEs) and TEAEs leading to discontinuation increased with ESL dose. The most common TEAEs were dizziness, somnolence, nausea, headache, and diplopia. Significance Adjunctive ESL 1,200 mg once-daily was more efficacious than placebo in adult patients with refractory partial-onset seizures. The once-daily 800 mg dose showed a marginal effect on SSF, but did not reach statistical significance. Both doses were well tolerated. Efficacy assessment was not affected by diary format used. PMID:25528898

Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis.

PubMed

Antoine, Marianne; Tag, Carmen G; Gressner, Axel M; Hellerbrand, Claus; Kiefer, Paul

2009-02-01

Leukocytes and tumor cells use E-selectin binding ligands to attach to activated endothelial cells expressing E-selectin during inflammation or metastasis. The cysteine-rich fibroblast growth factor receptor (CFR) represents the main E-selectin ligand (ESL-1) on granulocytes and its expression is exclusively modified by alpha(1,3)-fucosyltransferases IV or VII (FucT4 and FucT7). Hepatic stellate cells (HSC) are pericytes of liver sinusoidal endothelial cells. The activation of HSC and transdifferentiation into a myofibroblastic phenotype is involved in the repair of liver tissue injury, liver regeneration and angiogenesis of liver metastases. In the present study, we demonstrated that HSC expressed CFR together with FucT7 and exhibited a functional E-selectin binding activity on their cell surface. Since HSC appear to be oxygen-sensing cells, the expression of E-selectin binding activity was analyzed in HSC under a hypoxic atmosphere. While the expression of the glycoprotein CFR was unaffected by hypoxia, the cell-associated E-selectin binding activity decreased. However, under the same conditions, mRNA expression of the modifying enzyme FucT7 increased. The loss of E-selectin binding activity, therefore, appears to be neither the result of a reduced expression of the modifying transferase nor the expression of the backbone glycoprotein. After the transient transfection of HSC with CFR cDNA, the E-selectin binding activity (ESL-1) was efficiently released into the supernatant. Therefore, we hypothesize that under hypoxia, ESL-1 is shed from activated HSC. Our findings provide a novel perspective on the function of HSC in liver metastasis and inflammatory liver diseases.

Measurement of Creep Properties of Ultra-High-Temperature Materials by a Novel Non-Contact Technique

NASA Technical Reports Server (NTRS)

Hyers, Robert W.; Lee, Jonghyun; Rogers, Jan R.; Liaw, Peter K.

2007-01-01

A non-contact technique for measuring the creep properties of materials has been developed and validated as part of a collaboration among the University of Massachusetts, NASA Marshall Space Flight Center Electrostatic Levitation Facility (ESL), and the University of Tennessee. This novel method has several advantages over conventional creep testing. The sample is deformed by the centripetal acceleration from the rapid rotation, and the deformed shapes are analyzed to determine the strain. Since there is no contact with grips, there is no theoretical maximum temperature and no concern about chemical compatibility. Materials may be tested at the service temperature even for extreme environments such as rocket nozzles, or above the service temperature for accelerated testing of materials for applications such as jet engines or turbopumps for liquid-fueled engines. The creep measurements have been demonstrated to 2400 C with niobium, while the test facility, the NASA MSFC ESL, has processed materials up to 3400 C. Furthermore, the ESL creep method employs a distribution of stress to determine the stress exponent from a single test, versus the many tests required by conventional methods. Determination of the stress exponent from the ESL creep tests requires very precise measurement of the surface shape of the deformed sample for comparison to deformations predicted by finite element models for different stress exponents. An error analysis shows that the stress exponent can be determined to about 1% accuracy with the current methods and apparatus. The creep properties of single-crystal niobium at 1985 C showed excellent agreement with conventional tests performed according to ASTM Standard E-139. Tests on other metals, ceramics, and composites relevant to rocket propulsion and turbine engines are underway.

Containerless Processing of a Lithium Disilicate Glass

NASA Technical Reports Server (NTRS)

Ranasinghe, Kisa; Ray, Chandra S.; Day, Delbert E.; Rogers, Jan R.; Hyers, Robert W.; Rathz, Thomas

2004-01-01

Glasses of Li2O.2SiO2 (LS2), and LS2 doped with 0.001wt% platinum (LS2 + 0.001 wt% Pt) compositions were melted, cooled and reheated at controlled rates while levitated (containerless) inside an Electrostatic Levitator (ESL) furnace at the NASA Marshall Space Flight Center, Huntsville, AL. The experiments were conducted in vacuum (approximately 10(exp -5) Pa) using spherical, 2.5 to 3 millimeter diameter, glass samples. The measured critical cooling rate for glass formation, R(sub c), for the LS2 and LS2+0.001 wt% Pt glasses processed at ESL were 14 plus or minus 2 Celsius per minute and 130 plus or minus 5 Celsius per minute, respectively. The values of R(sub c), for the same LS2 and LS2 + 0.001 wt% Pt glasses processed in a container were 62 plus or minus 3 Celsius per minute and 162 plus or minus 5 Celsius per minute, respectively. The effective activation energy for crystallization, E, for this LS2 glass processed without a container at ESL, 392 plus or minus 15 kiloJoules per mole, was higher than that, 270 plus or minus 15 kiloJoules per mole, for an identical glass processed in a container. These results suggest that the glass formation tendency for a containerless LS2 melt is significantly increased compared to an identical melt in contact with a container. The absence of heterogeneous nucleation sites that are inherently present in all melts held in containers, and or a change in the surface composition due to evaporation of Li2O during processing at ESL are likely reasons for the increased glass forming tendency of this containerless LS2 melt.

Eslicarbazepine acetate in the treatment of adults with partial-onset epilepsy: an evidence-based review of efficacy, safety and place in therapy

PubMed Central

Lattanzi, Simona; Brigo, Francesco; Cagnetti, Claudia; Verrotti, Alberto; Zaccara, Gaetano; Silvestrini, Mauro

2018-01-01

Introduction Up to 30% of the patients diagnosed with epilepsy will continue suffering from seizures despite treatment with antiepileptic drugs, either in monotherapy or polytherapy. Hence, there remains the need to develop new effective and well-tolerated therapies. Aim The objective of this article was to review the evidence for the efficacy and safety of eslicarbazepine acetate (ESL) as adjunctive treatment in adult patients with focal onset seizures. Evidence review ESL is the newest, third-generation, single enantiomer member of the dibenzazepine family. Following oral administration, ESL is rapidly and extensively metabolized by hepatic first-pass hydrolysis to the active metabolite eslicarbazepine, which has linear, dose-proportional pharmacokinetics and low potential for drug-drug interactions. Eslicarbazepine works as a competitive blocker of the voltage gated sodium channels; unlike carbamazepine (CBZ) and oxcarbazepine (OXC), it has a lower affinity for the resting state of the channels, and reduces their availability by selectively enhancing slow inactivation. Efficacy and safety of ESL have been assessed in four randomized, Phase III clinical trials: the median relative reduction in standardized seizure frequency was 33.4% and 37.8% in the ESL 800 and 1,200 mg daily dose groups, and the responder rates were 33.8% and 43.1%, respectively. The incidence of treatment-emergent adverse events (TEAEs) increased with raising the dosage (ESL 400 mg: 63.8%, ESL 800 mg: 67.0%, ESL 1,200 mg: 73.1%). The TEAEs were generally mild to moderate in intensity, and the most common were dizziness, somnolence, headache and nausea. Open-label studies confirmed the findings from the pivotal trials and demonstrated sustained therapeutic effect of ESL over time and improvement of tolerability profile in patients switching from OXC/CBZ. No unexpected safety signals emerged over >5 years of follow-up. Conclusion Once-daily adjunctive ESL at the doses of 800 and 1,200 mg was effective to reduce the seizure frequency and was fairly well tolerated in adults with focal onset epilepsy. Starting treatment at 400 mg/day, followed by 400 mg increments every 7–14 days, could provide the optimal balance of efficacy and tolerability. PMID:29563858

Eslicarbazepine acetate as a replacement for levetiracetam in people with epilepsy developing behavioral adverse events.

PubMed

Jalihal, Virupakshi; Shankar, Rohit; Henley, William; Parrett, Mary; Tittensor, Phil; McLean, Brendan N; Ahmed, Ammad; Sander, Josemir W

2018-03-01

Psychiatric and behavioral side effects (PBSEs) are a major cause of antiepileptic drug (AED) withdrawal. Levetiracetam (LEV) is a recognized first-line AED with good seizure outcomes but recognized with PBSEs. Eslicarbazepine (ESL) is considered to function similarly to an active metabolite of the commonly used carbamazepine (CBZ). Carbamazepine is used as psychotropic medication to assist in various psychiatric illnesses such as mood disorders, aggression, and anxiety. The aim was to evaluate the psychiatric profile of ESL in people who had LEV withdrawn due to PBSEs in routine clinical practice to see if ESL can be used as a possible alternative to LEV. A retrospective observational review was conducted in two UK epilepsy centers looking at all cases exposed to ESL since its licensing in 2010. The ESL group was all patients with treatment-resistant epilepsy who developed intolerable PBSEs to LEV, subsequently trialed on ESL. The ESL group was matched to a group who tolerated LEV without intolerable PBSEs. Psychiatric disorders were identified from case notes. The Hamilton Depression Scale (HAM-D) was used to outcome change in mood. Clinical diagnoses of a mental disorder were compared between groups using the Fisher's exact test. Group differences in HAM-D scores were assessed using the independent samples t-test (alpha=0.05). The total number of people with active epilepsy in the two centers was 2142 of whom 46 had been exposed to ESL. Twenty-six had previous exposure to LEV and had intolerable PBSEs who were matched to a person tolerating LEV. There was no statistical differences in the two groups for mental disorders including mood as measured by HAM-D (Chi-square test: p=0.28). The ESL was well tolerated and did not produce significant PBSEs in those who had PBSEs with LEV leading to withdrawal of the drug. Though numbers were small, the findings suggest that ESL could be a treatment option in those who develop PBSEs with LEV and possibly other AEDs. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Eslicarbazepine acetate in the treatment of adults with partial-onset epilepsy: an evidence-based review of efficacy, safety and place in therapy.

PubMed

Lattanzi, Simona; Brigo, Francesco; Cagnetti, Claudia; Verrotti, Alberto; Zaccara, Gaetano; Silvestrini, Mauro

2018-01-01

Up to 30% of the patients diagnosed with epilepsy will continue suffering from seizures despite treatment with antiepileptic drugs, either in monotherapy or polytherapy. Hence, there remains the need to develop new effective and well-tolerated therapies. The objective of this article was to review the evidence for the efficacy and safety of eslicarbazepine acetate (ESL) as adjunctive treatment in adult patients with focal onset seizures. ESL is the newest, third-generation, single enantiomer member of the dibenzazepine family. Following oral administration, ESL is rapidly and extensively metabolized by hepatic first-pass hydrolysis to the active metabolite eslicarbazepine, which has linear, dose-proportional pharmacokinetics and low potential for drug-drug interactions. Eslicarbazepine works as a competitive blocker of the voltage gated sodium channels; unlike carbamazepine (CBZ) and oxcarbazepine (OXC), it has a lower affinity for the resting state of the channels, and reduces their availability by selectively enhancing slow inactivation. Efficacy and safety of ESL have been assessed in four randomized, Phase III clinical trials: the median relative reduction in standardized seizure frequency was 33.4% and 37.8% in the ESL 800 and 1,200 mg daily dose groups, and the responder rates were 33.8% and 43.1%, respectively. The incidence of treatment-emergent adverse events (TEAEs) increased with raising the dosage (ESL 400 mg: 63.8%, ESL 800 mg: 67.0%, ESL 1,200 mg: 73.1%). The TEAEs were generally mild to moderate in intensity, and the most common were dizziness, somnolence, headache and nausea. Open-label studies confirmed the findings from the pivotal trials and demonstrated sustained therapeutic effect of ESL over time and improvement of tolerability profile in patients switching from OXC/CBZ. No unexpected safety signals emerged over >5 years of follow-up. Once-daily adjunctive ESL at the doses of 800 and 1,200 mg was effective to reduce the seizure frequency and was fairly well tolerated in adults with focal onset epilepsy. Starting treatment at 400 mg/day, followed by 400 mg increments every 7-14 days, could provide the optimal balance of efficacy and tolerability.

ESL students learning biology: The role of language and social interactions

NASA Astrophysics Data System (ADS)

Jaipal, Kamini

This study explored three aspects related to ESL students in a mainstream grade 11 biology classroom: (1) the nature of students' participation in classroom activities, (2) the factors that enhanced or constrained ESL students' engagement in social interactions, and (3) the role of language in the learning of science. Ten ESL students were observed over an eight-month period in this biology classroom. Data were collected using qualitative research methods such as participant observation, audio-recordings of lessons, field notes, semi-structured interviews, short lesson recall interviews and students' written work. The study was framed within sociocultural perspectives, particularly the social constructivist perspectives of Vygotsky (1962, 1978) and Wertsch (1991). Data were analysed with respect to the three research aspects. Firstly, the findings showed that ESL students' preferred and exhibited a variety of participation practices that ranged from personal-individual to socio-interactive in nature. Both personal-individual and socio-interactive practices appeared to support science and language learning. Secondly, the findings indicated that ESL students' engagement in classroom social interactions was most likely influenced by the complex interactions between a number of competing factors at the individual, interpersonal and community/cultural levels (Rogoff, Radziszewska, & Masiello, 1995). In this study, six factors that appeared to enhance or constrain ESL students' engagement in classroom social interactions were identified. These factors were socio-cultural factors, prior classroom practice, teaching practices, affective factors, English language proficiency, and participation in the research project. Thirdly, the findings indicated that language played a significant mediational role in ESL students' learning of science. The data revealed that the learning of science terms and concepts can be explained by a functional model of language that includes: (1) the use of discourse to construct meanings, (2) multiple semiotic representations of the thing/process, and (3) constructing taxonomies and ways of reasoning. Other important findings were: talking about language is integral to biology teaching and learning, ESL students' prior knowledge of everyday words does not necessarily help them interpret written questions on worksheets, and ESL students' prior knowledge of concepts in their first language does not necessarily support concept learning in the second language.

Efficacy and safety of eslicarbazepine-acetate in elderly patients with focal epilepsy: Case series.

PubMed

Gómez-Ibáñez, A; Serratosa, J M; Guillamón, E; Garcés, M; Giráldez, B G; Toledo, M; Salas-Puig, J; López-González, F J; Rodríguez-Uranga, J; Castillo, A; Mauri, J A; Camacho, J L; López-Gomáriz, E; Giner, P; Torres, N; Palau, J; Molins, A; Villanueva, V

2017-05-01

Eslicarbazepine-acetate (ESL) is a third generation antiepileptic drug licensed as adjunctive therapy in adults with focal seizures. Efficacy and safety of ESL have been established in real-life setting. However, data about outcomes in elderly patients are scarce. Primary endpoint was to evaluate outcomes of ESL in elderly patients. This was a retrospective survey that included patients >65years with focal seizures who started ESL between January 2010 and July 2012 at 12 Spanish Hospitals. ESL was prescribed individually according to real-life practice. Efficacy and safety were evaluated over 1year. These patients were included within the bigger study ESLIBASE. We included 29 patients, most of them males (18). Mean age was 71.2 year-old and epilepsy evolution was 20 years. Eighteen were pharmacorresistant at baseline. At 12 months, the mean dose was 850mg/day, the retention rate 69%, the responder rate 62% and 24.1% were seizure-free. At 12 months, 16 patients (55.2%) had ≥1 adverse effect (AE), that led to discontinuation in 7 patients. Dizziness, nausea and ataxia were the most common AEs. The tolerability profile improved in 4/5 patients who switched from carbamazepine (CBZ) or oxcarbazepine (OXC) to ESL due to AEs. ESL was well-tolerated and effective in elderly patients in a real-life setting over 1year, with a dose around 800mg/day. AE effects improved in most of who switched from CBZ or OXC to ESL. Copyright © 2017 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Standards for Adult Education ESL Programs

ERIC Educational Resources Information Center

TESOL Press, 2013

2013-01-01

What are the components of a quality education ESL program? TESOL's "Standards for Adult Education ESL Programs" answers this question by defining quality components from a national perspective. Using program indicators in eight distinct areas, the standards can be used to review an existing program or as a guide in setting up a new…

Rethinking ESL Service Courses for International Graduate Students

ERIC Educational Resources Information Center

Min, Young-Kyung

2016-01-01

Drawing on data from a writing program in English as a second language (ESL) at a large university in the midwestern United States, this article addresses the significant gap in programmatic and pedagogical responses for graduate writing support by probing the notion of ESL service courses that approach graduate writing courses as being…

Career Development and Professional Attrition of Novice ESL Teachers of Adults

ERIC Educational Resources Information Center

Valeo, Antonella; Faez. Farahnaz

2013-01-01

Research and development in language teacher education and, more recently, teacher accreditation has had enormous impact on the professional lives of ESL teachers in Canada. There has been less interest, however, in examining the career development and employment experiences of accredited ESL teachers as they transition from TESL programs to ESL…

Accent, Identity, and a Fear of Loss? ESL Students' Perspectives

ERIC Educational Resources Information Center

McCrocklin, Shannon; Link, Stephanie

2016-01-01

Because many theorists propose a connection between accent and identity, some theorists have justifiably been concerned about the ethical ramifications of L2 pronunciation teaching. However, English-as-a-second-language (ESL) students often state a desire to sound like native speakers. With little research into ESL students' perceptions of links…

Learner's Learning Experiences & Difficulties towards (ESL) among UKM Undergraduates

ERIC Educational Resources Information Center

Maarof, Nooreiny; Munusamy, Indira Malani A/P

2015-01-01

This paper aims to investigate the learners learning experiences and difficulties of ESL among the UKM undergraduates. This study will be focusing on identifying the factors behind Malaysian undergraduate's experiences and also their difficulties in the English as Second Language (ESL) classroom. This paper discusses some of the issues of English…

The Impact of a Computer-Mediated Shadowing Activity on ESL Speaking Skill Development: A Pilot Study

ERIC Educational Resources Information Center

Mishima, Masakazu; Cheng, Lixia

2017-01-01

This pilot study explored the instructional value and potential of a computer-mediated shadowing activity for improving English as a Second Language (ESL) learners' speech intelligibility. Prospective International Teaching Assistants (ITAs), who were enrolled in an ESL classroom communication class at a large public university, completed a…

Perceptions of ESL Program Management in Canadian Higher Education: A Qualitative Case Study

ERIC Educational Resources Information Center

Eaton, Sarah Elaine

2017-01-01

ESL programs at post-secondary institutions must often generate revenue in addition to teaching students English. Institutions often impose explicit expectations on these programs to generate profit, creating unique challenges for those who administer them. This qualitative case study investigated challenges faced by ESL program directors at one…

Science Education and ESL Students

ERIC Educational Resources Information Center

Allen, Heather; Park, Soonhye

2011-01-01

The number of students who learn English as a second language (ESL) in U.S. schools has grown significantly in the past decade. This segment of the student population increased by 56% between the 1994-95 and 2004-05 school years (NCLR 2007). As the ESL student population increases, many science teachers struggle to tailor instructional materials,…

ILGWU Worker-Family Education Program. ESL/Technical Curriculum Manual.

ERIC Educational Resources Information Center

Friedman, Judy; Friedman, Deidre

The curriculum for the International Ladies' Garment Workers' Union (ILGWU) English as a Second Language (ESL) and technical classes is a collection of instructional materials and suggestions focusing on workplace-related topics and issues. This guide is intended for use in classes where one technical and one ESL teacher are present and where…

Contextualized Workforce Skills and ESL Learner Identity

ERIC Educational Resources Information Center

Vafai, Maliheh Mansuripur

2016-01-01

This article reports on an empirical case study centering on adult ESL learners' motivational patterns for learning English and its relevance to their career goals. It looks at past patterns of immigrant insertion within the socioeconomic context of the US and explores current trends in adult ESL curriculum development focused on the task of…

Teachers' Stories: Expanding the Boundaries with the Participatory Approach.

ERIC Educational Resources Information Center

Hewitt, Lee; And Others

Compiled by a group of teachers new to the English-as-a-Second-Language (ESL) field, this volume contains writing samples from teachers involved in the participatory approach to ESL classroom instruction. Introductory notes by Lee Hewitt cite the participatory approach as the most compelling method for teaching ESL adult learners. The…

Serious ESL Lessons Await Students In The Funny Pages

ERIC Educational Resources Information Center

Curriculum Review, 2005

2005-01-01

This brief article discusses how carefully selected comic strips can become great teaching aids for (English Second Language) ESL instructors. They are beneficial in part because they provide brief conversations in English with pictures that help convey the meaning of the words. ESL teacher Dina Dahbany-Miraglia, author of Speaking American…

Computer-Assisted Text-Analysis for ESL Students.

ERIC Educational Resources Information Center

Reid, Joy; And Others

1983-01-01

Reports an investigation into possibilities of using word processors and text analysis software with English as second language (ESL) students to determine (1) if foreign students can learn to use computer equipment, (2) if students feel time invested is worthwhile, and (3) if ESL students' problems with writing American academic prose can be…

Vocabulary Acquisition in an Academic Discipline: ESL Learners and Theology.

ERIC Educational Resources Information Center

Lessard-Clouston, Michael

A study investigated and compared the acquisition of specialized vocabulary among English-as-a-Second Language (ESL) and native English-speaking (NES) graduate students in theology. Research was undertaken in an anglophone city in central Canada. Subjects were 12 students (5 Chinese ESLs, 7 NESs) enrolled in an introductory core theology course. A…

Transfer of Mother Tongue Rhetoric among Undergraduate Students in Second Language Writing

ERIC Educational Resources Information Center

Saffari, Narges; Noordin, Shahrina Md; Sivapalan, Subarna; Zahedpisheh, Nahid

2017-01-01

Mother tongue rhetoric transfer is unavoidable in ESL writings, especially for Iranian ESL learners, since Persian and English language is quite different. The paper discusses the negative transfer of mother tongue rhetoric in Iranian undergraduate ESL learners' writings from the perspectives of choosing rhetorical structure in English and Persian…

An Investigation of How ESL Students Write.

ERIC Educational Resources Information Center

Raimes, Ann

A study is described which investigated the differences between English-as-a-second-language (ESL) writers and native-English-speaking writers and examined closely a range of ESL writers and their composing processes. The procedures used were those used by Sondra Perl in a study of the composing processes of unskilled college writers (1979).…

Guidelines for the Selection of Topical Content in ESL Programs

ERIC Educational Resources Information Center

Deckert, Glenn

2004-01-01

The author contends that the topical content of ESL lesson materials in schools and universities is of ethical significance. Based on an established model for ethical judgment in social services, five guidelines for ethical selection of lesson topics are proposed and illustrated. Lesson topics must help ESL students: (a) adjust to local…

Toward Wider Use of Literature in ESL: Why and How.

ERIC Educational Resources Information Center

Gajdusek, Linda

1988-01-01

Discusses English as a second language (ESL) theory as it relates to the use of literature, and presents a four-step approach to any literary text that obliges ESL students to take responsibility for building their own successively more complex schemata. This approach is illustrated with Hemingway's short story "Soldier's Home." (Author/LMO)

ESL Students Writing Autobiographies: Are There Any Connections?

ERIC Educational Resources Information Center

Wu, Ruoyi

A doctoral student's interest in self-culture connections led her to observe an English-as-a-Second-Language (ESL) writing class focused on autobiography and read all the students' papers. Autobiographical writing not only gives ESL students a chance to write about what matters to them, but the teacher can capitalize on students' cultural…

Lexical Borrowings in the ESL Classrooms in Malaysia

ERIC Educational Resources Information Center

Thirusanku, Jantmary; Yunus, Melor Md

2013-01-01

This paper attempts to show the use of lexical borrowings in ten teaching materials used by the English as Second Language (ESL) teachers in the ESL classrooms in the National Secondary Schools in the Klang district in Selangor, Malaysia. It also discusses the general and pedagogical implications involved in using lexical borrowings. This paper…

The Reliability of the OWLS Written Expression Scale with ESL Kindergarten Students

ERIC Educational Resources Information Center

Harrison, Gina L.; Ogle, Keira C.; Keilty, Megan

2011-01-01

A reliability analysis was conducted on the Written Expression Scale from the Oral and Written Language Scales, (OWLS, Carrow-Woolfolk, 1996), with 68 ESL and 56 non-ESL kindergarten students. Interrater and internal consistency estimates for the Written Expression Scale were examined separately for each language group. Despite lower oral English…

Using Literature and Multiple Technologies in ESL Instruction

ERIC Educational Resources Information Center

Traore, Moussa; Kyei-Blankson, Lydia

2010-01-01

Many instructors are using literary texts along with language structure books in English as a Secondary Language (ESL) classrooms with the aim of increasing students' language skills. Since literature is often written to portray a particular cultural or authentic experience, the material presented may not be familiar to ESL students. Also, the…

Using E-Portfolios and ESL Learners

ERIC Educational Resources Information Center

Alawdat, Maha

2013-01-01

This study examines the use of e-portfolios for ESL (English as a second language) learners. The data were collected by reviewing 11 empirical studies from 2010-2012 in order to synthesize meaningful information about e-portfolios for ESL/EFL (English as a foreign language) acquisition. The studies were coded into two main categories: learning…

Guide to Resources for ESL Literacy Facilitators.

ERIC Educational Resources Information Center

Gaber-Katz, Elaine; Zettel, Kathryn

This resource guide, for English-as-a-Second-Language (ESL) literacy facilitators, reviews a variety of resources for ESL literacy. The guide contains three sections. The first section cites four books that provide a theoretical context for literacy work: "Ah-Hah! A New Approach to Popular Education" (Gatt-Fly); "Approaches and Methods in Language…

Conversations in the Workplace: An ESL Activity Guide.

ERIC Educational Resources Information Center

Falagrady, Teresa; Gossard, Linda; Ingram, Pam; Snapp, Mary

This guide was designed to help English-as-a-second-language (ESL) instructors teach work-related language. All the language areas in the guide address communication situations that ESL students would be likely to encounter in the workplace. The guide is divided into departments at the worksite where conversations between non-native English…

Patterns of Question Selection and Writing Performance of ESL Students.

ERIC Educational Resources Information Center

Chiste, Katherine Beaty; O'Shea, Judith

1988-01-01

Reports on a study examining the pattern of question selection by English as a Second Language (ESL) students on a writing competence test and the relationship to performance. Results suggest that ESL students heavily favored first and second questions in each set of four questions, and shorter questions in sets. (CB)

ESL Students' Interaction in Second Life: Task-Based Synchronous Computer-Mediated Communication

ERIC Educational Resources Information Center

Jee, Min Jung

2010-01-01

The purpose of the present study was to explore ESL students' interactions in task-based synchronous computer-mediated communication (SCMC) in Second Life, a virtual environment by which users can interact through representational figures. I investigated Low-Intermediate and High-Intermediate ESL students' interaction patterns before, during, and…

ESL Instruction and Adults with Learning Disabilities. ERIC Digest.

ERIC Educational Resources Information Center

Schwarz, Robin; Terrill, Lynda

This digest reviews what is known about adult English-as-a-Second-Language (ESL) learners and learning disabilities, suggests ways to identify and assess ESL adults who may have learning disabilities, and offers practical methods for both instruction and teacher training. Topics covered in some detail include identifying and diagnosing learning…

Basic Training and Resource Connections for Novice ESL Teachers

ERIC Educational Resources Information Center

Henrichsen, Lynn

2010-01-01

A large number of teachers and tutors of English as a Second Language (ESL) lack professional-level preparation. The Basic Training and Resources for Teaching English to Speakers of Other Languages (BTRTESOL) program is being developed to prepare untrained, novice, volunteer ESL teachers to be more successful. In contrast with previous programs…

Using Music in the Adult ESL Classroom. ERIC Digest.

ERIC Educational Resources Information Center

Lems, Kristen

Music can be used in the adult English-as-a-Second-Language (ESL) classroom to create a learning environment; to build listening comprehension, speaking, reading, and writing skills; to increase vocabulary; and to expand cultural knowledge. This digest looks briefly at research and offers strategies for using music in the adult ESL classroom.…

Opinions from ESL instructors and students about curricula on hepatitis B for use in immigrant communities.

PubMed

Coronado, Gloria D; Taylor, Victoria M; Hislop, T Gregory; Teh, Chong; Acorda, Elizabeth; Do, H Hoai; Chen, Hueifang; Thompson, Beti

2008-01-01

Chinese immigrants in Canada have a disproportionately high risk for hepatitis B compared with non-Hispanic Whites. Hepatitis B is the leading cause of hepatocellular carcinoma among Asian immigrants to North America. English-as-a-second-language (ESL) classes are an effective way of reaching newly immigrated individuals and are a potential channel for delivering health messages. Using data from 6 focus groups among ESL instructors and students, we characterized perceptions about activities that are successfully used in ESL classrooms and strategies for delivering hepatitis B information. RESULTS. Instructors and students generally reported that activities that focused on speaking and listening skills and that addressed content relevant to students' daily lives were successful in the classroom. Instructors generally avoided material that was irrelevant or too difficult to understand. Focus group participants offered strategies for delivering hepatitis B information in ESL classrooms; these strategies included addressing symptoms and prevention and not singling out a specific population subgroup to avoid stigmatization. These findings might assist efforts to develop ESL curricula that target immigrant populations.

Perceptions of school nurses on the challenges of service provision to ESL students.

PubMed

Whitman, Marilyn V; Davis, Jullet A; Terry, Allison J

2010-04-01

The number of English-as-as second-language (ESL) students in public schools across the country is rising creating unique challenges for school health services with the introduction of new cultures and languages. This study describes the perceptions of school nurses in Alabama schools regarding the challenges they face when communicating with ESL students and their parents. The population consists of school nurses in Alabama public schools. The obtained sample of 1,429 responses is presented and discussed. Urban school nurses were more likely to have access to an interpreter, yet they were more likely to rely on an ESL student to act as a translator when speaking to his/her parents. Kindergarten through elementary school nurses were more likely to witness an increase in ESL students and encounter difficulty communicating with these students and their parents. School nurses have a unique opportunity to engage parents of ESL students in the health of their child, thus it is vital that they be provided with cultural facts and encouraged to use interpreter services to lessen language barriers.

Opinions from ESL Instructors and Students about Curricula on Hepatitis B for Use in Immigrant Communities

PubMed Central

Coronado, Gloria D.; Taylor, Victoria M.; Hislop, T. Gregory; Teh, Chong; Acorda, Elizabeth; Do, H. Hoai; Chen, Hueifang; Thompson, Beti

2010-01-01

Background Chinese immigrants in Canada have a disproportionately high risk for hepatitis B compared with non-Hispanic whites. Hepatitis B is the leading cause of hepatocellular carcinoma among Asian immigrants to North America. English as a Second Language (ESL) classes are an effective way of reaching newly immigrated individuals and are a potential channel for delivering health messages. Methods Using data from six focus groups among ESL instructors and students, we characterized perceptions about activities that are successfully used in ESL classrooms and strategies for delivering hepatitis B information. Results Instructors and students generally reported that activities which focused on speaking and listening skills and that addressed content relevant to students' daily lives were successful in the classroom. Instructors generally avoided material that was irrelevant or too difficult to understand. Focus group participants offered strategies for delivering hepatitis B information in ESL classrooms; these strategies included addressing symptoms and prevention, and not singling out a specific population subgroup in order to avoid stigmatization. Conclusions These findings might assist efforts to develop ESL curricula that target immigrant populations. PMID:18709587

ESL Placement and Schools

PubMed Central

Callahan, Rebecca; Wilkinson, Lindsey; Muller, Chandra; Frisco, Michelle

2010-01-01

In this study, the authors explore English as a Second Language (ESL) placement as a measure of how schools label and process immigrant students. Using propensity score matching and data from the Adolescent Health and Academic Achievement Study and the National Longitudinal Study of Adolescent Health, the authors estimate the effect of ESL placement on immigrant achievement. In schools with more immigrant students, the authors find that ESL placement results in higher levels of academic performance; in schools with few immigrant students, the effect reverses. This is not to suggest a one-size-fits-all policy; many immigrant students, regardless of school composition, generational status, or ESL placement, struggle to achieve at levels sufficient for acceptance to a 4-year university. This study offers several factors to be taken into consideration as schools develop policies and practices to provide immigrant students opportunities to learn. PMID:20617111

Influence of titration schedule and maintenance dose on the tolerability of adjunctive eslicarbazepine acetate: An integrated analysis of three randomized placebo-controlled trials.

PubMed

Krauss, Gregory; Biton, Victor; Harvey, Jay H; Elger, Christian; Trinka, Eugen; Soares da Silva, Patrício; Gama, Helena; Cheng, Hailong; Grinnell, Todd; Blum, David

2018-01-01

To examine the influence of titration schedule and maintenance dose on the incidence and type of treatment-emergent adverse events (TEAEs) associated with adjunctive eslicarbazepine acetate (ESL). Data from three randomized, double-blind, placebo-controlled trials were analyzed. Patients with refractory partial-onset seizures were randomized to maintenance doses of ESL 400, 800, or 1200mg QD (dosing was initiated at 400 or 800mg QD) or placebo. The incidence of TEAEs was analyzed during the double-blind period (2-week titration phase; 12-week maintenance phase), according to the randomized maintenance dose and the titration schedule. 1447 patients were included in the analysis. During the first week of treatment, 62% of patients taking ESL 800mg QD had ≥1 TEAE, vs 35% of those taking 400mg QD and 32% of the placebo group; dizziness, somnolence, nausea, and headache were numerically more frequent in patients taking ESL 800mg than those taking ESL 400mg QD. During the double-blind period, the incidences of common TEAEs were lower in patients who initiated ESL at 400mg vs 800mg QD. For the 800 and 1200mg QD maintenance doses, rates of TEAEs leading to discontinuation were lower in patients who began treatment with 400mg than in those who began taking ESL 800mg QD. Initiation of ESL at 800mg QD is feasible. However, initiating treatment with ESL 400mg QD for 1 or 2 weeks is recommended, being associated with a lower incidence of TEAEs, and related discontinuations. For some patients, treatment may be initiated at 800mg QD, if the need for more immediate seizure reduction outweighs concerns about increased risk of adverse reactions during initiation. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Evidence for a pharmacokinetic interaction between eslicarbazepine and rosuvastatin: Potential effects on xenobiotic transporters.

PubMed

Gidal, Barry E; Mintzer, Scott; Schwab, Matthias; Schutz, Ralph; Kharidia, Jahnavi; Blum, David; Grinnell, Todd; Sunkaraneni, Soujanya

2017-09-01

Patients with partial-onset seizures and comorbid cardiovascular disease may concomitantly receive eslicarbazepine acetate (ESL), an antiepileptic drug, and rosuvastatin, an HMG-CoA reductase inhibitor. This study evaluated the effect of multiple-dose ESL on the pharmacokinetic (PK) parameters of a single dose of rosuvastatin in healthy subjects. This was a Phase I, single-center, fixed-sequence, open-label study. Healthy subjects received two treatments, in sequence. Treatment A: a single 40mg oral dose of rosuvastatin on Day 1, followed by a washout period (Days 1-4); treatment B: titration of ESL (400-800mg once daily) on Days 5-18, followed by ESL 1200mg once daily on Days 19-35, with a single dose of rosuvastatin (40mg) on Day 32. Subjects then entered a 2-week follow-up period. Plasma concentrations of rosuvastatin were quantified for PK analyses. Safety and tolerability were assessed throughout the study. Thirty-three healthy subjects were enrolled and 30 completed the study. Mean rosuvastatin (standard deviation) t 1/2 was similar when rosuvastatin was used concomitantly with ESL and when it was used alone (26.5 [16.3]h, and 22.4 [9.5]h, respectively). The geometric least squares mean ratios (90% confidence intervals) of rosuvastatin exposure levels between rosuvastatin used concomitantly with ESL and rosuvastatin used alone were as follows: C max , 64.0% (55.9-73.3%); AUC (0-∞) , 63.0% (57.1-69.4%); and AUC (0-last) , 60.9% (55.2-67.1%). Concomitant use of ESL and rosuvastatin was generally well tolerated. Rosuvastatin exposure was 36-39% lower with steady-state administration of ESL, potentially due to reduced oral bioavailability of rosuvastatin. Consequently, when rosuvastatin is used with ESL, a rosuvastatin dose adjustment may be necessary if a clinically significant change in lipids is noted. Copyright © 2017. Published by Elsevier B.V.

Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate-A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome.

PubMed

Svendsen, Torleiv; Brodtkorb, Eylert; Reimers, Arne; Molden, Espen; Sætre, Erik; Johannessen, Svein I; Johannessen Landmark, Cecilie

2017-01-01

Eslicarbazepine acetate (ESL) is a new antiepileptic drug (AED), still insufficiently studied regarding pharmacokinetic variability, efficacy and tolerability. The purpose of this study was to evaluate therapeutic drug monitoring (TDM) data in Norway and relate pharmacokinetic variability to clinical efficacy and tolerability in a long-term clinical setting in patients with refractory epilepsy. This retrospective observational study included TDM-data from the main laboratories and population data from the Norwegian Prescription Database in Norway, in addition to clinical data from medical records of adult patients using ESL for up to three years, whenever possible. TDM-data from 168 patients were utilized for assessment of pharmacokinetic variability, consisting of 71% of the total number of patients in Norway using ESL, 2011-14. Median daily dose of ESL was 800mg (range 400-1600mg), and median serum concentration of ESL was 53μmol/L (range 13-132μmol/L). Inter-patient variability of ESL was extensive, with 25-fold variability in concentration/dose ratios. Additional clinical data were available from 104 adult patients out of the 168, all with drug resistant focal epilepsy. After 1, 2 and 3 years follow-up, the retention rate of ESL was 83%, 72% and 64%, respectively. ESL was generally well tolerated as add-on treatment, but sedation, cognitive impairment and hyponatremia were reported. Hyponatremia (sodium <137mmol/L) was present in 36% of the patients, and lead to discontinuation in three. Pharmacokinetic variability of ESL was extensive and the demonstration of usefulness of TDM requires further studies. In patients with drug resistant focal Epilepsy, the high retention rate indicated good efficacy and tolerability. Hyponatremia was observed in one third of the patients. The present results point to a need for individualization of treatment and TDM may be useful. Copyright © 2016 Elsevier B.V. All rights reserved.

An academic writing needs assessment of English-as-a-second-language clinical investigators.

PubMed

Wang, Min-Fen; Bakken, Lori L

2004-01-01

Academic writing for publication is competitive and demanding for researchers. For the novice English-as-a-second-language (ESL) researcher, the pressure to publish compounds the difficulties of mastering the English language. Very few studies have used ESL graduate and post-graduate students as academic writing research subjects. The purpose of this project was to assess the learning needs of ESL clinical investigators regarding academic writing for English scholarly publication. A qualitative evaluation approach was used to examine the gap between the current and desired proficiency level for the academic writing of ESL clinical investigators. We considered the perspectives of seven ESL clinical investigators plus three mentors and three writing instructors. Semi-structured questions were asked. Field notes were organized using a field-work recording system. They were analyzed using the constant comparative method. ESL clinical investigators do not accurately perceive their writing deficiencies. They have little knowledge of criteria for academic writing and they are influenced by their prior English learning experiences in their home culture, which engender passive attitudes toward seeking appropriate writing resources. Adequate time is especially needed to develop successful writing skills. Four basic steps are recommended to guide program planners in developing ESL writing activities for professional learning: (1) recognize discrepancies, (2) establish clear standards and performance criteria for scholarly writing, (3) develop individual plans, and (4) organize long-term writing assistance.

Comparative Difficulties with Non-Scientific General Vocabulary and Scientific/Medical Terminology in English as a Second Language (ESL) Medical Students.

PubMed

Heming, Thomas A; Nandagopal, Shobha

2012-11-01

Medical education requires student comprehension of both technical (scientific/medical) and non-technical (general) vocabulary. Our experience with "English as a second language" (ESL) Arab students suggested they often have problems comprehending scientific statements because of weaknesses in their understanding of non-scientific vocabulary. This study aimed to determine whether ESL students have difficulties with general vocabulary that could hinder their understanding of scientific/medical texts. A survey containing English text was given to ESL students in the premedical years of an English-medium medical school in an Arabic country. The survey consisted of sample questions from the Medical College Admission Test (USA). Students were instructed to identify all unknown words in the text. ESL students commenced premedical studies with substantial deficiencies in English vocabulary. Students from English-medium secondary schools had a selective deficiency in scientific/medical terminology which disappeared with time. Students from Arabic-medium secondary schools had equal difficulty with general and scientific/medical vocabulary. Deficiencies in both areas diminished with time but remained even after three years of English-medium higher education. Typically, when teaching technical subjects to ESL students, attention is focused on subject-unique vocabulary and associated modifiers. This study highlights that ESL students also face difficulties with the general vocabulary used to construct statements employing technical words. Such students would benefit from increases in general vocabulary knowledge.

The Conflation of Adult ESL and Literacy: The Views of Experienced Teachers

ERIC Educational Resources Information Center

Fleming, Douglas; René, Carène Pierre; Bangou, Francis; Sarwar, Gul Shahzad

2015-01-01

This article explores the links between English as a second language (ESL) instruction and literacy instruction through an examination of viewpoints from eight teachers in two Canadian provinces. Four of these teachers worked in government--funded adult ESL and literacy education programs for a large urban school district in the province of…

Training Using Technology in the Adult ESL Classroom

ERIC Educational Resources Information Center

McClanahan, Lorna

2014-01-01

In this article I discuss two reasons for the slow adoption of technology as an instructional tool in adult English as a Second Language (ESL) education. I outline recent facts about the relationships between today's adult ESL learners and technology, and then construct a background of theoretical support in favor of integrating technology in…

Divergence in Curricular-Weight Teacher-Efforts and Student-Difficulties in Secondary School ESL

ERIC Educational Resources Information Center

Abdul Gafoor, K.; Sreeja, C.

2013-01-01

The increasing importance of English as a global language, calls for an equally vigorous attempt to improving teaching and learning it in schools as a second language within and outside India. Highlighting the relevance of contextualising ESL learning by allowing for the needs of students and teachers in undertaking reforms to ESL learning, this…

Developing Reading Comprehension Modules to Facilitate Reading Comprehension among Malaysian Secondary School ESL Students

ERIC Educational Resources Information Center

Javed, Muhammad; Eng, Lin Siew; Mohamed, Abdul Rashid

2015-01-01

The study aims to develop a set of 6 Reading Comprehension Modules (RCMs) for Malaysian ESL teachers to facilitate different reading abilities of ESL students effectively. Different skill categories were selected for developing the RCMs. This article describes how and why diverse texts of varying length were adopted and adapted from various…

Tuning In: Using the News for a Content-Based ESL Class

ERIC Educational Resources Information Center

Moglen, Daniel

2014-01-01

Vast amounts of daily news content are widely available and easily accessible, and they can be converted into materials for intermediate and advanced ESL classes. This article will describe the why and how for integrating news media sources into a multiskills ESL classroom. Through the news, students are immediately engaged with the material…

The Knowledge Base of Non-Native English-Speaking Teachers: Perspectives of Teachers and Administrators

ERIC Educational Resources Information Center

Zhang, Fengjuan; Zhan, Ju

2014-01-01

This study explores the knowledge base of non-native English-speaking teachers (NNESTs) working in the Canadian English as a second language (ESL) context. By examining NNESTs' experiences in seeking employment and teaching ESL in Canada, and investigating ESL program administrators' perceptions and hiring practices in relation to NNESTs, it…

Transforming ESL Teachers' Perspective on Media Literacy: An Action Research Project

ERIC Educational Resources Information Center

Rodriguez Sanchez, Doralis

2017-01-01

Transforming ESL teachers' perspective on media literacy: An action research project was carried out at a Puerto Rico Department of Education (PRDE) public high school in the Metropolitan area. The participants of the study were five ESL teachers. Professional development was the intervention used in this study. The participants were introduced to…

Principled Eclecticism: Approach and Application in Teaching Writing to ESL/EFL Students

ERIC Educational Resources Information Center

Alharbi, Sultan H.

2017-01-01

The principal purpose of this paper is to critically examine and evaluate the efficacy of the principled eclectic approach to teaching English as second/foreign language (ESL/EFL) writing to undergraduate students. The paper illustrates that this new method adapts mainstream writing pedagogies to individual needs of learners of ESL/EFL in order to…

The Experiences in Processing Policies and Contracts by Adult ESL Readers

ERIC Educational Resources Information Center

Abiog, Evalyn B.

2017-01-01

The present study describes the experiences of adult English as a Second Language (ESL) readers in processing legal texts prior to entering a financial agreement. A preliminary survey was conducted to determine the commonly read policies and contracts of adult ESL reader-consumers, which revealed those of banks and life-insurance companies; hence,…

Digital Storytelling in ESL Instruction: Identity Negotiation through a Pedagogy of Multiliteracies

ERIC Educational Resources Information Center

Vinogradova, Polina

2011-01-01

This qualitative descriptive exploratory study investigated how a pedagogy of multiliteracies can be introduced to the ESL curriculum using digital stories and explored the ways ESL learners negotiate their identities through the multimodality of this narrative genre. The study was based on the premise that in language education it is crucial to…

Differences in Less Proficient and More Proficient ESL College Writing in the Philippine Setting

ERIC Educational Resources Information Center

Gustilo, Leah E.

2016-01-01

The present study aimed at characterizing what skilled or more proficient ESL college writing is in the Philippine setting through a contrastive analysis of three groups of variables identified from previous studies: resources, processes, and performance of ESL writers. Based on Chenoweth and Hayes' (2001; 2003) framework, the resource level…

Closed-Captioned Video and the ESL Classroom: A Multi-Sensory Approach

ERIC Educational Resources Information Center

Rowland, James L.

2007-01-01

Traditional ESL instruction accepts the idea that a student's ability to visualize text and to create mental pictures of letters and whole words is important in comprehension. Closed-captioned video presentations can be useful in English as a Second Language (ESL) instruction. Video topics rich with the history and culture of the target language…

Language Learning Strategy Use of ESL Students in an Intensive English Learning Context

ERIC Educational Resources Information Center

Hong-Nam, Kyungsim; Leavell, Alexandra G.

2006-01-01

This study investigated the language learning strategy use of 55 ESL students with differing cultural and linguistic backgrounds enrolled in a college Intensive English Program (IEP). The IEP is a language learning institute for pre-admissions university ESL students, and is an important step in developing not only students' basic Interpersonal…

Fusing Pedagogic Horizons: Language and Content Teaching in the Mainstream

ERIC Educational Resources Information Center

Arkoudis, Sophie

2005-01-01

One of the central concerns of English as a Second Language (ESL) education within many English-speaking countries has been the relationship between content and language teaching. In Victoria, a state of Australia, the educational policy of mainstreaming ESL is presented as a means of catering to the language learning needs of ESL students within…

Writing with Computers in ESL Classroom: Enhancing ESL Learners' Motivation, Confidence and Writing Proficiency

ERIC Educational Resources Information Center

Hadi, Marham Jupri

2013-01-01

Researcher's observation on his ESL class indicates the main issues concerning the writing skills: learners' low motivation to write, minimum interaction in writing, and poor writing skills. These limitations have led them to be less confidence to write in English. This article discusses how computers can be used for the purpose of increasing…

ESL Teacher Education Abroad and at Home: A Cautionary Tale

ERIC Educational Resources Information Center

Pray, Lisa; Marx, Sherry

2010-01-01

In this article, we compared teacher attitudes and beliefs about culturally appropriate language teaching resulting from an examination of two groups of preservice teachers. One group of preservice teachers enrolled in an English as a Second Language (ESL) study abroad program in Mexico; the other enrolled in a traditional on-campus ESL program.…

Negotiating Grammatical Choices: Academic Language Learning by Secondary ESL Students

ERIC Educational Resources Information Center

Shin, Sarah J.

2009-01-01

This paper reports on a part of a year-long investigation into high school ESL students' academic language development. Eight participants were pulled out of their intermediate ESL class for weekly 50-minute sessions with the author for a year. While the main focus of the sessions was reading news magazine articles for meaning, the author…

Teaching More Than English: Connecting ESL Students to Their Community through Service Learning

ERIC Educational Resources Information Center

Russell, Natalie M.

2007-01-01

Language and cultural differences often cause English as a second language (ESL) students to feel alienated from their school and their community. As a result, they tend to make friends primarily within their own ESL classes and avoid interacting with mainstream students and getting involved in school activities. This article describes how…

The Challenges of the Ontario Secondary School Literacy Test for Second Language Students

ERIC Educational Resources Information Center

Cheng, Liying; Klinger, Don A.; Zheng, Ying

2007-01-01

Results from the Ontario Secondary School Literacy Test (OSSLT) indicate that English as a Second Language (ESL) and English Literacy Development (ELD) students have comparatively low success and high deferral rates. This study examined the 2002 and 2003 OSSLT test performances of ESL/ELD and non-ESL/ELD students in order to identify and…

Empirical Study on Learners' Self-Efficacy in ESL/EFL Context

ERIC Educational Resources Information Center

Shi, Lihong

2016-01-01

With the popularity of learner-oriented approach in language teaching, research on learners is gaining more and more importance. This paper attempts to review the empirical researches on self-efficacy in the ESL/EFL settings during the past 10 years with the purpose of depicting the extent to which the self-efficacy research in ESL/EFL has…

Cultural Competence in Alberta Schools: Perceptions of ESL Families in Four Major School Boards

ERIC Educational Resources Information Center

Ngo, Hieu V.

2012-01-01

Complex linguistic, acculturative, and social needs of English-as-a-second-language (ESL) learners challenge the K-12 education system to develop cultural competence in working with culturally diverse families. This study surveyed 242 self-identified ESL students and their parents from four of Alberta's major school boards. Results of the survey…

Influence of Speech Anxiety on Oral Communication Skills among ESL/EFL Learners

ERIC Educational Resources Information Center

Khan, Said Muhammad

2015-01-01

The realization of speech anxiety among ESL/EFL learners is important. Once understood, these feelings of fear or nervousness may be relieved and the desired objectives of learning the target language may be achieved. The study has attempted to measure the level of anxiety among ESL/EFL learners at HITEC University, Taxila, Pakistan. The current…

Content-Learning Tasks for Adult ESL Learners: Promoting Literacy for Work or School

ERIC Educational Resources Information Center

Ewert, Doreen E.

2014-01-01

Teachers of English as a second language (ESL) are often on the frontline of working with adult ESL learners who are facing a difficult developmental pathway to academic and/or economic success. These learners come to the task of learning English with widely varying schooling experiences, degrees of first language literacy, and English language…

ESL VI Curriculum Guide.

ERIC Educational Resources Information Center

Flander, Leonard

This curriculum guide for English as a Second Language (ESL) Level VI is the sixth of six in a Guam Community College ESL project series. The other five guides, a companion teacher's guide and pre- and post-tests are available separately (see note). The entire project centers around the Peabody Kits P, Level P, Level 1, Level 2, Level 3, and the…

ESL V Curriculum Guide.

ERIC Educational Resources Information Center

Flander, Leonard

This curriculum guide for English as a Second Language (ESL) Level V is the fifth of six in the Guam Community College ESL project series. The other five guides, a companion teacher's guide, and pre- and post-tests are available separately (see note). The entire project centers around the Peabody Kits P, Level P, Level 1, Level 2, Level 3, and the…

Mental Health and the ESL Classroom: A Guide for Teachers Working with Refugees.

ERIC Educational Resources Information Center

Lucey, Moira; Chaffee, Marcia; Terry, Diane; Le Marbre, Joan; Stone, Betty; Wiencek, Donna

This manual guides English-as-a-Second-Language (ESL) teachers by outlining the complex burdens that refugee students carry and setting out concrete steps that ESL teachers can take in order to turn their classrooms into effective and welcoming teaching and learning environments. The seven sections focus on the following: (1) "The Refugee and…

A Review of the Four Most Widely-Used ESL Texts by LLA/LVA Affiliates.

ERIC Educational Resources Information Center

Spelleri, Maria

This report reviews four English-as-a-Second-Language (ESL) textbooks, using criteria developed for volunteer-based organizations (VBOs). It illustrates the process that VBOs need to undertake prior to ESL textbook selection. The four texts include the following: "Laubach Way to English" (J. Macero and M. Lane), which focuses on linguistic rather…

Marketing of Revenue-Generating ESL Programs at the University of Calgary: A Qualitative Study

ERIC Educational Resources Information Center

Eaton, Sarah Elaine

2009-01-01

This qualitative case study endeavored to understand how program managers at one post-secondary Canadian university define, understand and undertake the marketing of their revenue-generating English as a Second Language (ESL) programs. Data were collected through interviews with three managers of distinct English as a Second Language (ESL)…

Changes in the Motivation of Chinese ESL Learners: A Qualitative Investigation

ERIC Educational Resources Information Center

Li, Qi

2017-01-01

This article reports on a case study that investigated changes in the motivation of Chinese ESL learners over a three month period of residence in an English-speaking environment. The participants consisted of 11 Chinese ESL learners, who were tertiary students and taking general or academic English courses in New Zealand. They took part in the…

Investment and Return: Wiki Engagement in a "Remedial" ESL Writing Course

ERIC Educational Resources Information Center

Nakamaru, Sarah

2012-01-01

This study explores the extent to which students in a community college remedial English as a second language (ESL) course engaged with a class wiki and the relationship between their pattern of engagement over time and success in exiting remediation. Participants included 47 students in two sections of ESL writing during the spring 2009 semester.…

Linguistic Characteristics of ESL Writing in Task-based E-mail Activities.

ERIC Educational Resources Information Center

Li, Yili

2000-01-01

Investigated the efficacy of integrating task-based e-mail activities into a process-oriented English-as-Second-Language (ESL) writing class. Particular focus was on the linguistic characteristics of 132 pieces of e-mail writing by ESL students in tasks that differed in terms of purpose, audience interaction, and task structure. Computerized text…

The Perceptions of Japanese Students toward Academic English Reading: Implications for Effective ESL Reading Strategies

ERIC Educational Resources Information Center

Iwai, Yuko

2008-01-01

The population of English as a Second Language (ESL) learners has increased significantly in higher education settings in the United States today. It has been reported that Japanese ESL students are generally unsuccessful when studying in English speaking countries. The typical way of reading in English for Japanese students is the…

Pocket Electronic Dictionaries for Second Language Learning: Help or Hindrance?

ERIC Educational Resources Information Center

Tang, Gloria M.

1997-01-01

Reports on the concerns of English-as-a-Second-Language (ESL) teachers in Canada regarding their students' use of pocket bilingual electronic dictionaries (EDs). The article highlights the ED's features, uses, and effectiveness as a tool for learning ESL at the secondary level and ESL students' perceptions of the ED's usefulness. (nine references)…

Using Facebook-Based e-Portfolio in ESL Writing Classrooms: Impact and Challenges

ERIC Educational Resources Information Center

Barrot, Jessie S.

2016-01-01

In English as a second language (ESL) writing pedagogy, much attention has been given to electronic portfolio (e-portfolio) assessment via social networking sites. However, little is known about how Facebook can be used as an e-portfolio platform. Hence, this paper describes the impact of Facebook-based e-portfolio on ESL students' writing…

Total meltwater volume since the Last Glacial Maximum and viscosity structure of Earth's mantle inferred from relative sea level changes at Barbados and Bonaparte Gulf and GIA-induced J˙2

NASA Astrophysics Data System (ADS)

Nakada, Masao; Okuno, Jun'ichi; Yokoyama, Yusuke

2016-02-01

Inference of globally averaged eustatic sea level (ESL) rise since the Last Glacial Maximum (LGM) highly depends on the interpretation of relative sea level (RSL) observations at Barbados and Bonaparte Gulf, Australia, which are sensitive to the viscosity structure of Earth's mantle. Here we examine the RSL changes at the LGM for Barbados and Bonaparte Gulf ({{RSL}}_{{L}}^{{{Bar}}} and {{RSL}}_{{L}}^{{{Bon}}}), differential RSL for both sites (Δ {{RSL}}_{{L}}^{{{Bar}},{{Bon}}}) and rate of change of degree-two harmonics of Earth's geopotential due to glacial isostatic adjustment (GIA) process (GIA-induced J˙2) to infer the ESL component and viscosity structure of Earth's mantle. Differential RSL, Δ {{RSL}}_{{L}}^{{{Bar}},{{Bon}}} and GIA-induced J˙2 are dominantly sensitive to the lower-mantle viscosity, and nearly insensitive to the upper-mantle rheological structure and GIA ice models with an ESL component of about (120-130) m. The comparison between the predicted and observationally derived Δ {{RSL}}_{{L}}^{{{Bar}},{{Bon}}} indicates the lower-mantle viscosity higher than ˜2 × 1022 Pa s, and the observationally derived GIA-induced J˙2 of -(6.0-6.5) × 10-11 yr-1 indicates two permissible solutions for the lower mantle, ˜1022 and (5-10) × 1022 Pa s. That is, the effective lower-mantle viscosity inferred from these two observational constraints is (5-10) × 1022 Pa s. The LGM RSL changes at both sites, {{RSL}}_{{L}}^{{{Bar}}} and {{RSL}}_{{L}}^{{{Bon}}}, are also sensitive to the ESL component and upper-mantle viscosity as well as the lower-mantle viscosity. The permissible upper-mantle viscosity increases with decreasing ESL component due to the sensitivity of the LGM sea level at Bonaparte Gulf ({{RSL}}_{{L}}^{{{Bon}}}) to the upper-mantle viscosity, and inferred upper-mantle viscosity for adopted lithospheric thicknesses of 65 and 100 km is (1-3) × 1020 Pa s for ESL˜130 m and (4-10) × 1020 Pa s for ESL˜125 m. The former solution of (1-3) × 1020 Pa s is consistent with the inferences from the postglacial differential RSL changes in the Australian region and also inversion study of far-field sea-level data. The inference of the viscosity structure based on these four observational constraints is, however, relatively insensitive to the viscosity structure of D″ layer.

A realistic multimodal modeling approach for the evaluation of distributed source analysis: application to sLORETA.

PubMed

Cosandier-Rimélé, D; Ramantani, G; Zentner, J; Schulze-Bonhage, A; Dümpelmann, M

2017-10-01

Electrical source localization (ESL) deriving from scalp EEG and, in recent years, from intracranial EEG (iEEG), is an established method in epilepsy surgery workup. We aimed to validate the distributed ESL derived from scalp EEG and iEEG, particularly regarding the spatial extent of the source, using a realistic epileptic spike activity simulator. ESL was applied to the averaged scalp EEG and iEEG spikes of two patients with drug-resistant structural epilepsy. The ESL results for both patients were used to outline the location and extent of epileptic cortical patches, which served as the basis for designing a spatiotemporal source model. EEG signals for both modalities were then generated for different anatomic locations and spatial extents. ESL was subsequently performed on simulated signals with sLORETA, a commonly used distributed algorithm. ESL accuracy was quantitatively assessed for iEEG and scalp EEG. The source volume was overestimated by sLORETA at both EEG scales, with the error increasing with source size, particularly for iEEG. For larger sources, ESL accuracy drastically decreased, and reconstruction volumes shifted to the center of the head for iEEG, while remaining stable for scalp EEG. Overall, the mislocalization of the reconstructed source was more pronounced for iEEG. We present a novel multiscale framework for the evaluation of distributed ESL, based on realistic multiscale EEG simulations. Our findings support that reconstruction results for scalp EEG are often more accurate than for iEEG, owing to the superior 3D coverage of the head. Particularly the iEEG-derived reconstruction results for larger, widespread generators should be treated with caution.

A realistic multimodal modeling approach for the evaluation of distributed source analysis: application to sLORETA

NASA Astrophysics Data System (ADS)

Cosandier-Rimélé, D.; Ramantani, G.; Zentner, J.; Schulze-Bonhage, A.; Dümpelmann, M.

2017-10-01

Objective. Electrical source localization (ESL) deriving from scalp EEG and, in recent years, from intracranial EEG (iEEG), is an established method in epilepsy surgery workup. We aimed to validate the distributed ESL derived from scalp EEG and iEEG, particularly regarding the spatial extent of the source, using a realistic epileptic spike activity simulator. Approach. ESL was applied to the averaged scalp EEG and iEEG spikes of two patients with drug-resistant structural epilepsy. The ESL results for both patients were used to outline the location and extent of epileptic cortical patches, which served as the basis for designing a spatiotemporal source model. EEG signals for both modalities were then generated for different anatomic locations and spatial extents. ESL was subsequently performed on simulated signals with sLORETA, a commonly used distributed algorithm. ESL accuracy was quantitatively assessed for iEEG and scalp EEG. Main results. The source volume was overestimated by sLORETA at both EEG scales, with the error increasing with source size, particularly for iEEG. For larger sources, ESL accuracy drastically decreased, and reconstruction volumes shifted to the center of the head for iEEG, while remaining stable for scalp EEG. Overall, the mislocalization of the reconstructed source was more pronounced for iEEG. Significance. We present a novel multiscale framework for the evaluation of distributed ESL, based on realistic multiscale EEG simulations. Our findings support that reconstruction results for scalp EEG are often more accurate than for iEEG, owing to the superior 3D coverage of the head. Particularly the iEEG-derived reconstruction results for larger, widespread generators should be treated with caution.

Efficacy and tolerability of brivaracetam compared to lacosamide, eslicarbazepine acetate, and perampanel as adjunctive treatments in uncontrolled focal epilepsy: Results of an indirect comparison meta-analysis of RCTs.

PubMed

Brigo, Francesco; Bragazzi, Nicola Luigi; Nardone, Raffaele; Trinka, Eugen

2016-11-01

Brivaracetam (BRV), eslicarbazepine acetate (ESL), lacosamide (LCM), and perampanel (PER) have been recently marketed as adjunctive treatments for focal onset seizures. To date, no randomized controlled trial (RCT) has directly compared BRV with ESL, LCM, or PER. To compare BRV with the other add-on AEDs in patients with uncontrolled focal epilepsy, estimating their efficacy and tolerability through an adjusted, common-reference based indirect comparison meta-analysis. We systematically searched RCTs in which add-on treatment with ESL or LCM in patients with focal onset seizures have been compared with placebo. Efficacy and tolerability outcomes were considered. Random-effects Mantel-Haenszel meta-analyses were performed to obtain odds ratios (ORs) for the efficacy of BRV, LCM, ESL, or PER versus placebo. Adjusted indirect comparisons were then made between BRV and the other three AEDs using the obtained results, comparing the minimum and the highest effective recommended daily dose of each drug. Seventeen RCTs, with a total of 4971 patients were included. After adjusting for dose-effects, indirect comparisons showed no difference between BRV and LCM, ESL, or PER for responder rate and seizure freedom. Lower adverse events were observed with high dose BRV compared to high dose ESL or PER, but no difference was found in withdrawing because of adverse events. Indirect comparisons do not demonstrate a significant difference in efficacy between add-on BRV and LCM, ESL, or PER in focal epilepsy, and might suggest a better tolerability of BRV than ESL, and possibly also PER, at the highest effective recommended dose. Copyright © 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Real-world data on eslicarbazepine acetate as add-on to antiepileptic monotherapy.

PubMed

Holtkamp, M; McMurray, R; Bagul, M; Sousa, R; Kockelmann, E

2016-07-01

To assess retention, tolerability, and safety, efficacy and effects on quality of life (QoL) of eslicarbazepine acetate (ESL) add-on treatment over 6 months in a real-world adult population with partial-onset seizures. This non-interventional, multicenter, prospective study was performed in eight European countries. Adult patients (n = 247) for whom the physician had decided to initiate ESL as add-on to an existing antiepileptic drug (AED) monotherapy were invited to participate. The study comprised three visits: baseline, and after 3 and 6 months. Data on ESL retention, efficacy, tolerability, safety, and QoL were collected. After 6 months, the retention rate of ESL was 82.2%, and 81.8% of patients reported a reduction of seizure frequency of at least 50%; 39.2% of patients reported seizure freedom at this time. The mean QOLIE-10 score improved from 2.9 (SD ± 0.8) at baseline to 2.1 (SD ± 0.8) after 6 months. 109 adverse events (AEs) were reported in 57 patients (26.0%); the majority were rated as related to ESL by the investigator and led to a discontinuation of ESL in 25 patients (11.4%). Eight patients (3.7%) suffered at least one serious AE. The most frequently reported AEs were dizziness, headache, convulsion, and fatigue. This study shows that ESL was well tolerated and efficacious as add-on therapy to one baseline AED. The use of ESL in patients less refractory than those included in previous clinical trials led to higher responder and seizure freedom rates. No new safety issues were observed. © 2016 Esai Europe Ltd. Acta Neurologica Scandinavica published by John Wiley & Sons Ltd.

Understanding extreme sea levels for broad-scale coastal impact and adaptation analysis

NASA Astrophysics Data System (ADS)

Wahl, T.; Haigh, I. D.; Nicholls, R. J.; Arns, A.; Dangendorf, S.; Hinkel, J.; Slangen, A. B. A.

2017-07-01

One of the main consequences of mean sea level rise (SLR) on human settlements is an increase in flood risk due to an increase in the intensity and frequency of extreme sea levels (ESL). While substantial research efforts are directed towards quantifying projections and uncertainties of future global and regional SLR, corresponding uncertainties in contemporary ESL have not been assessed and projections are limited. Here we quantify, for the first time at global scale, the uncertainties in present-day ESL estimates, which have by default been ignored in broad-scale sea-level rise impact assessments to date. ESL uncertainties exceed those from global SLR projections and, assuming that we meet the Paris agreement goals, the projected SLR itself by the end of the century in many regions. Both uncertainties in SLR projections and ESL estimates need to be understood and combined to fully assess potential impacts and adaptation needs.

ESL Placement and Schools: Effects on Immigrant Achievement.

PubMed

Callahan, Rebecca; Wilkinson, Lindsey; Muller, Chandra; Frisco, Michelle

2009-05-01

In this study, the authors explore English as a Second Language (ESL) placement as a measure of how schools label and process immigrant students. Using propensity score matching and data from the Adolescent Health and Academic Achievement Study and the National Longitudinal Study of Adolescent Health, the authors estimate the effect of ESL placement on immigrant achievement. In schools with more immigrant students, the authors find that ESL placement results in higher levels of academic performance; in schools with few immigrant students, the effect reverses. This is not to suggest a one-size-fits-all policy; many immigrant students, regardless of school composition, generational status, or ESL placement, struggle to achieve at levels sufficient for acceptance to a 4-year university. This study offers several factors to be taken into consideration as schools develop policies and practices to provide immigrant students opportunities to learn.

Titanium-Zirconium-Nickel Alloy Inside Marshall's Electrostatic Levitator (ESL)

NASA Technical Reports Server (NTRS)

2003-01-01

This Photo, which appeared on the July cover of `Physics Today', is of the Electrostatic Levitator (ESL) at NASA's Marshall Space Flight Center (MSFC). The ESL uses static electricity to suspend an object (about 3-4 mm in diameter) inside a vacuum chamber allowing scientists to record a wide range of physical properties without the sample contracting the container or any instruments, conditions that would alter the readings. Once inside the chamber, a laser heats the sample until it melts. The laser is then turned off and the sample cools, changing from a liquid drop to a solid sphere. In this particular shot, the ESL contains a solid metal sample of titanium-zirconium-nickel alloy. Since 1977, the ESL has been used at MSFC to study the characteristics of new metals, ceramics, and glass compounds. Materials created as a result of these tests include new optical materials, special metallic glasses, and spacecraft components.

A Very Important Lesson: Respect and the Socialization of Order(s) in High School ESL

ERIC Educational Resources Information Center

Talmy, Steven

2009-01-01

The "stigma" associated with ESL in K-12 public schools is a widely referenced if little explored topic. In this paper, I consider how this "stigma" was produced in a high school ESL class in Hawai'i, specifically, as it was licensed by and framed in terms of teaching students "respect." Based on analysis of two…

Becoming Sociocultural Mediators: What All Educators Can Learn from Bilingual and ESL Teachers

ERIC Educational Resources Information Center

Nieto, Sonia

2017-01-01

In this article, the author focuses specifically on how what she calls non-specialist teachers (i.e., those who are neither bilingual nor ESL teachers) can benefit from the practices of bilingual and ESL teachers, and how teacher educators can incorporate this knowledge in their curriculum and pedagogy. To do so, she uses examples from research…

The Relationship between Reading Proficiency and Reading Strategy Use: A Study of Adult ESL Learners

ERIC Educational Resources Information Center

Huang, Jiuhan; Nisbet, Deanna

2014-01-01

This article explores the relationship between reading strategy use and reading proficiency among 121 adult ESL learners. Reading strategy use was measured by the SORS, and reading proficiency was determined by the CASAS Reading Test and BEST Literacy Test. Findings of the study reveal that (a) adult ESL learners are active strategies users; (b)…

A Pedagogical Framework for Technology Integration in ESL Classrooms: The Promises and Challenges of Integration

ERIC Educational Resources Information Center

Yang, Sha; Walker, Victoria

2015-01-01

Technologies have the potential to support language teaching and learning, but English as a Second Language (ESL) teachers in the United States (U.S.) either sparingly use technologies for instruction or use them at low level. Although previous research has indicated some promises and challenges faced by U.S. ESL teachers with integrating…

Prereferral Process with Latino English Language Learners with Specific Learning Disabilities: Perceptions of English-as-a-Second-Language Teachers

ERIC Educational Resources Information Center

Ferlis, Emily; Xu, Yaoying

2016-01-01

This study explored perceptions of English-as-a-second-language (ESL) teachers on the prereferral process for Latino English language learners (ELLs). Using Colaizzi's (1978) phenomenological approach, qualitative data were collected through interviews with four ESL teachers. Analyses of the data indicated that the ESL teachers used research-based…

Placement of English as a Second Language (ESL) Student Learners in Higher Education

ERIC Educational Resources Information Center

Banegas, Michael R.

2013-01-01

Immigration into the U.S. will continue to increase in the coming years, thereby increasing the postsecondary enrollment of ESL students. Yet there is still a limited amount of research designed to evaluate which ESL placement programs are most effective. This study was designed to determine if the use of correct testing instruments would ensure…

Japanese Female Students in an American ESL Class: Cultural Conflict and Change.

ERIC Educational Resources Information Center

Miyakoshi, Yoshiko

This study investigated the process of change and acculturation in a group of Japanese female students studying English as a Second Language (ESL) in the United States. The first part of the report, based on data from five questionnaires administered to 36 students, discusses what the students did in their 6-week ESL class and how they reacted…

Perspectives on Community College ESL, Volume 1: Pedagogy, Programs, Curricula, and Assessment

ERIC Educational Resources Information Center

Spaventa, Marilyn, Ed.; Machado, Craig, Ed.

2006-01-01

English as a second language (ESL) programs in community colleges are as diverse in the models they follow as the students they serve. This volume provides a detailed look at how faculty and administrators are tailoring their ESL programs to best serve the needs of their students and the missions of their institutions. The authors of the thirteen…

Readings on English as a Second Language.

ERIC Educational Resources Information Center

Croft, Kenneth, Ed.

This collection of readings on the topic of teaching English as a second language (ESL) has a twofold purpose: to enlarge the ESL teacher's awareness of the field and to assist in the professional growth of the new teacher or teacher-trainee. Each of the book's nine sections deal with one area of ESL instruction. Section 1, "Trends and Practices,"…

Content-ESL across the USA. Volume III: A Training Packet. A Descriptive Study of Content-ESL Practices.

ERIC Educational Resources Information Center

Burkart, Grace Stovall; Sheppard, Ken

The 15 guides included in this training packet were compiled from data gathered during a 3-year study of content-English-as-a-Second-Language (content-ESL) programs across the United States. These 15 guides are intended as stepping stones and idea-generators and include information on curriculum development, material selection and adaptation, and…

Research, Classroom Practice, Programs. Improving the Odds: Helping ESL Students Succeed. Selected Papers from the CUNY ESL Council Conference (New York, New York, February 1987).

ERIC Educational Resources Information Center

City Univ. of New York, NY. Instructional Resource Center.

Papers presented at the City University of New York's English-as-a-Second-Language (ESL) Council conference on maximizing the chances for success of limited-English-proficient college students include the following: "Thresholds, Alienation, and Syntax" (Geoffrey Summerfield); "Storytelling: Starting with the Familiar" (A. Duku…

What Prevents ESL/FL Writers from Avoiding Plagiarism? Analyses of 10 North-American College Websites.

ERIC Educational Resources Information Center

Yamada, Kyoko

2003-01-01

Discusses how inexperienced English-as-a-Second/Foreign-Language (ESL/EFL) writers can be helped to avoid plagiarism. Analyzes 10 North American Web sites on plagiarism, which provide a window to understanding how this issue has been problemitized and explained in Anglophone academic contexts. Concludes ESL/EFL may need to emphasize the role of…

Put Reading First: Positive Effects of Direct Instruction and Scaffolding for ESL Learners Struggling with Reading

ERIC Educational Resources Information Center

Van Staden, Annalene

2011-01-01

The inability of many English second-language (ESL) learners to read at desirable levels is universal, but reasons for this and solutions have not yet been addressed. Within the South African teaching context especially there is a paucity of evidence-based research findings available on the literacy challenges faced by ESL learners and the…

Compton Community College General Education Associate of Arts/Certification, Bilingual Immersion Program for the California State University System.

ERIC Educational Resources Information Center

Camacho, Julian S.

The Compton Community College (CCC) General Education Associate of Arts/Certification Bilingual Immersion Program (BIP) is designed to allow English-as-a-Second-Language (ESL) or limited English proficiency (LEP) students to study subjects beyond ESL in a bilingual setting. Current ESL programs offer students no oppurtunity to take degree/transfer…

Improving Reading Skills in ESL Students through an Intensive Vocabulary Building Program.

ERIC Educational Resources Information Center

Gaudio, Vince

This report describes a program for improving the reading skills of English-as-a-Second-Language (ESL) students. The targeted population consists of 19 ESL students, ranging in age from 7-10 years, in a western suburb of a large metropolitan city in Illinois. The problem of poor reading ability was documented through low reading scores on the STAR…

ESL Population and Program Patterns in Community Colleges. ERIC Digest.

ERIC Educational Resources Information Center

Ignash, Jan M.

Recent trends in immigration and foreign student enrollments are placing a growing demand on community colleges for English-as-a-Second-Language (ESL) instruction. A 1991 study of course sections at 164 two-year colleges nationwide revealed that ESL had grown from 30% of all foreign language courses offered in 1983 to 51% in 1991, and that the…

Linking Research and Practice: Effective Strategies for Teaching Vocabulary in the ESL Classroom

ERIC Educational Resources Information Center

Nam, Jihyun

2010-01-01

Vocabulary plays a pivotal role in the ESL classroom. Whereas a considerable amount of research has examined effective ESL vocabulary teaching and learning, missing are studies that provide examples of how to put various research findings into practice: that is, apply them to real texts including target vocabulary items. In order to close the gap…

We're All in the Same Boat. A Multi-Cultural and Pre-Vocational ESL Curriculum for Intermediate ESL Students.

ERIC Educational Resources Information Center

Batt, Karen

This curriculum manual combines the teaching of English as a second language (ESL) with multicultural and prevocational education. The materials provide students with information about immigration, how immigrants fit into the economic system and society, and how different cultures and races have evolved. Goals are to give students the opportunity…

Relationship between Bilingual Instruction and Learners' Performance in English as Second Language Context

ERIC Educational Resources Information Center

Khan, Huma Imran

2015-01-01

The prime purpose of this study was to explore a correlation between bilingual instruction in an ESL class and the class performance of the ESL learners at the secondary level. Quantitative research method was used to evaluate the test performance of 60 ESL learners divided into two groups: One was the controlled group (which was given…

The ESL Lab as Tutorial and Learning Center.

ERIC Educational Resources Information Center

Sherwood, Walter; Davis, Margaret Robbins

A language laboratory component became an integral part of the ESL (English as a second language) program at Sacramento City College when student enrollment increased and a freeze on hiring new teachers went into effect. While the number of class hours of each ESL course was reduced, an hour or two per week of laboratory work was added. The term…

Hidden Losses: How Demographics Can Encourage Incorrect Assumptions about ESL High School Students' Success

ERIC Educational Resources Information Center

Toohey, Kelleen; Derwing, Tracey M.

2008-01-01

Data from ESL students' records in Vancouver are examined in the light of the BC Ministry of Education's claim that ESL high school students are more successful than students whose first language is English. We argue that the academic achievement of well-to-do students whose parents are skilled workers or entrepreneurs may mask the completion…

Becoming "Local" in ESL: Racism as Resource in a Hawai'i Public High School

ERIC Educational Resources Information Center

Talmy, Steven

2010-01-01

Drawn from a 2.5 year critical ethnography in the ESL program of a Hawai'i public high school (Tradewinds High), this article examines racializing and racist conduct directed at Micronesian students by a group of old-timer ESL students, primarily of East/Southeast Asian inheritance. Racialization and racism directed at Micronesians positioned them…

The Year in Review: Reports of Research Conducted by Adult Education Practitioners-Researchers in Virginia. Volume 5: 1995-1996.

ERIC Educational Resources Information Center

Virginia Adult Educators Research Network, Dayton.

This report contains four separate articles of interest to adult English-as-a-second-language (ESL) educators. "Learning Disabilities in Adult ESL: Case Studies and Directions" (Dorothy Almanza, Kate Singleton, Lynda Terrill) looks at three case studies of adult ESL students whom teachers have identified as possibly learning disabled.…

English as a Second Language Teachers and the Use of New Media: Collaboration and Connection

ERIC Educational Resources Information Center

Paraiso, Johnna

2012-01-01

The role of the ESL teacher is that of both educator and advocate. Frequently ESL teachers work with a population that presents complex challenges to the school culture at large. The distribution of the ELL population within a school system may require the ESL teacher to fulfill responsibilities at multiple schools, thus maintaining an itinerant…

Counting Words: Successful Sentences for Beginning ESL Adult Learners Using the Product Approach

ERIC Educational Resources Information Center

Gardner, Susanne

2017-01-01

The majority of correctional students of English as a second language (ESL) in Maryland come to school with limited formal education in their first language. Education has not been prioritized, and formal writing ability is absent. It then becomes a challenge to motivate students to successful writing, as is required by the state. ESL students at…

Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I.

PubMed

Grunze, Heinz; Kotlik, Eduardo; Costa, Raquel; Nunes, Teresa; Falcão, Amílcar; Almeida, Luis; Soares-da-Silva, Patrício

2015-03-15

Eslicarbazepine acetate (ESL) is an anticonvulsant approved as an adjunctive therapy in adults with partial-onset seizures. To evaluate the efficacy, safety and tolerability of ESL in the treatment of acute mania and prevention of recurrence in bipolar disorder I. Two 3-week multicentre, double-blind, randomised, placebo-controlled studies in acute mania (study BIA-2093-203: dose titrated by response, ESL 600-1800mg or 800-2400mg, once-daily; study BIA-2093-204: fixed doses of 600, 1200 and 1800mg, once-daily) were followed by a recurrence prevention study consisting of a 2-week open-label period (900mg, once-daily) continued by a double-blind, parallel-group, fixed dose (300, 900 and 1800mg, once-daily) period for a minimum of 6 months. The primary endpoint was changed from baseline until the end of the 3-week treatment period in Young Mania Rating Scale (YMRS) in studies BIA-2093-203 and BIA-2093-204, and the proportion of patients showing no worsening according to the Clinical Global Impressions - Bipolar Version (CGI-BP) over Part II in study BIA-2093-205. In study BIA-2093-203 (n=160, ITT), neither dose group was statistically different from placebo in the primary endpoint, though the ESL 800-2400mg showed a greater reduction in YMRS score (p=0.0523). CGI-BP score changes for mania and overall bipolar illness indicate a significant improvement in patient symptomatology for the ESL 800-2400mg group (from preceding and worst phase) and for ESL 600-1800mg group (from worst phase only) when compared to placebo. Study BIA-2093-204 (n=38) results were inconclusive due to premature termination caused by recruitment difficulties. In study BIA-2093-205 (n=85, ITT), at least 50% of patients showed no worsening in all treatment groups (p=0.250). ESL adverse events were mostly of mild and moderate intensities and consistent with previously reported observations for ESL. ESL treatment was not significantly different from placebo in manic patients in the primary outcome, but secondary outcomes may be suggestive of efficacy. The recurrence prevention study provides preliminary support for efficacy of ESL in patients recovered from an acute manic episode. Copyright © 2014 Elsevier B.V. All rights reserved.

Literature and Language Teaching: Exploring Literary Texts with the Language Learner and Re-Creating Literature in the ESL Classroom.

ERIC Educational Resources Information Center

Lazar, Gillian; Heath, Shirley Brice

1996-01-01

Two educators discuss the role literature plays in the English as a Second Language (ESL) classroom. One emphasizes that literary texts are a source for classroom activities that can motivate learners. The other points out that the English writings of ESL students about their travels and friends published in newsletters and journals generate…

Mainstream Teacher Candidates' Perspectives on ESL Writing: The Effects of Writer Identity and Rater Background

ERIC Educational Resources Information Center

Kang, Hyun-Sook; Veitch, Hillary

2017-01-01

This study explored the extent to which the ethnic identity of a writer and the background (gender and area of teaching) of a rater can influence mainstream teacher candidates' evaluation of English as a second language (ESL) writing, using a matched-guise method. A one-page essay was elicited from an ESL learner enrolled in an intensive English…

An Argument against Using Standardized Test Scores for Placement of International Undergraduate Students in English as a Second Language (ESL) Courses

ERIC Educational Resources Information Center

Kokhan, Kateryna

2013-01-01

Development and administration of institutional ESL placement tests require a great deal of financial and human resources. Due to a steady increase in the number of international students studying in the United States, some US universities have started to consider using standardized test scores for ESL placement. The English Placement Test (EPT)…

Building Interactional Space in an ESL Classroom to Foster Bilingual Identity and Linguistic Repertoires

ERIC Educational Resources Information Center

Welch, Irene

2015-01-01

This article draws on data from a yearlong case study of a Mexican American ESL teacher's practice in a K-5 school in the southeastern United States. The study examines how the teacher established bilingual interactional space in her ESL pullout class consisting of six 9- to 11-year old students of Mexican descent. The analysis shows the ways in…

Factors of Significant Impact on Proficiency Levels of Adult ESL Learners within Post-Secondary Education in Puerto Rico

ERIC Educational Resources Information Center

Perez, Ramon

2011-01-01

This qualitative case study seeks to identify factors that have a significant impact on the second language proficiency levels of adult English as a Second Language (ESL) learners at a four-year university in Puerto Rico. Current data indicate that a significant percentage of adult ESL learners encounter major difficulties within the process of…

Cottage Crafts Final Report. ESL Cottage Industry Education and Employment Program. July 1, 1982 - June 30, 1983. A 310 Adult Education Project.

ERIC Educational Resources Information Center

Henry, Jean; And Others

The ESL (English as a second language) Cottage Industry Education and Employment Program was developed to provide ESL and life skills instruction to homebound and elderly refugees while, at the same time, fostering the continuation of native crafts and folklife. The program was the cooperative effort of local adult education staff, leaders and…

Making the Invisible Visible: A Responsive Evaluation Study of ESL and Spanish Language Services for Immigrants in a Small Rural County in Indiana

ERIC Educational Resources Information Center

Pawan, Faridah; Thomalla, Therese Groff

2005-01-01

This article describes a responsive evaluation study of ESL services and Spanish language services for immigrants in a rural county in Indiana. An ESL specialist led the evaluation of language services in the county from the perspectives of language providers and recipients. The responsive evaluation--a form of action research that uses…

How Should Different Types of Feedback Be Administered to Create More Effective Learning among Advanced ESL Writing Students? A Student Perspective

ERIC Educational Resources Information Center

Bao, Ze

2015-01-01

This paper is set in the context of my experience in advanced ESL writing classes at two Canadian universities. Based on my experience and the research literature, several types of feedback should be administered by teachers to create more effective learning opportunities among advanced ESL writing students. In this paper, I examine the advantages…

Understanding L2 Speaking Problems: Implications for ESL Curriculum Development in a Teacher Training Institution in Hong Kong

ERIC Educational Resources Information Center

Gan, Zhengdong

2012-01-01

This paper reports the result of a study that aimed to identify the problems with oral English skills of ESL (English as a second language) students at a tertiary teacher training institution in Hong Kong. The study, by way of semi-structured interview, addresses the gap in our understanding of the difficulties ESL students encountered in their…

Neighbourhood ethnic diversity buffers school readiness impact in ESL children.

PubMed

Puchala, Chassidy; Vu, Lan T H; Muhajarine, Nazeem

2010-01-01

Contextual factors, as measured by neighbourhood characteristics, shape the experiences children have and affect their "school readiness", i.e., whether they are well or poorly prepared for the transition from home to kindergarten. This study assessed the independent effects of individual and neighbourhood factors on school readiness; specifically, it examined whether and to what degree neighbourhood factors modified children's language ability and thus their school readiness in a population of children in Saskatoon, Saskatchewan. The study included all children attending kindergarten in 2001, 2003 and 2005 in Saskatoon. School readiness and child characteristics were measured by the Early Development Instrument (EDI). The EDI measures child development at school commencement in five domains: physical health and well-being, social competence, emotional maturity, cognitive and language development, and communication skills and general knowledge. Data from the 2001 Census were used to characterize Saskatoon's neighbourhoods. Multilevel modeling examined the independent and buffering or exacerbating effects of individual and neighbourhood factors on the relation between English as a Second Language (ESL) status in children and EDI domain scores. ESL children had significantly lower scores on all EDI domains compared with non-ESL children. Certain factors (e.g., younger age, male, Aboriginal status, having special needs) were significantly related to lower readiness in terms of the emotional maturity, and communication skills and general knowledge domains. Importantly, children who lived in neighbourhoods that were highly transient (with a higher proportion of residents who had moved in the previous year) had lower EDI scores on both domains, and those in neighbourhoods with lower rates of employment had lower EDI scores on communication skills and general knowledge. Neighbourhood ethnic diversity mitigated the negative impact of ESL status on school readiness for both domains. ESL children from neighbourhoods with a high degree of ethnic diversity had higher EDI scores than ESL children from neighbourhoods with low ethnic diversity. The current study provided insight regarding the impact of contextual factors in addition to individual factors, such as ESL status, on school readiness outcomes. Future research should continue to examine contextual factors related to ESL status and early child developmental outcomes, particularly focusing on the mechanisms of influence.

Pooled efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Data from four double-blind placebo-controlled pivotal phase III clinical studies.

PubMed

Elger, Christian; Koepp, Mathias; Trinka, Eugen; Villanueva, Vicente; Chaves, João; Ben-Menachen, Elinor; Kowacs, Pedro A; Gil-Nagel, António; Moreira, Joana; Gama, Helena; Rocha, José-Francisco; Soares-da-Silva, Patrício

2017-12-01

Pooled evaluation of the key efficacy and safety profile of eslicarbazepine acetate (ESL) added-on to stable antiepileptic therapy in adults with focal-onset seizures. Data from 1703 patients enrolled in four phase III double-blind, randomized, placebo-controlled studies were pooled and analyzed. Following a 2 week titration period, ESL was administered at 400 mg, 800 mg, and 1200 mg once-daily doses for 12 weeks (maintenance period). Pooled efficacy variable was standardized (/4 weeks) seizure frequency (SSF) analyzed over the maintenance period as reduction in absolute and relative SSF and proportion of responders (≥50% reduction in SSF). Pooled safety was analyzed by means of adverse events and clinical laboratory assessments. SSF was significantly reduced with ESL 800 mg (P < 0.0001) and 1200 mg (P < 0.0001) compared to placebo. Median relative reduction in SSF was 33.4% for ESL 800 mg and 37.8% for 1200 mg (placebo: 17.6%), and responder rate was 33.8% and 43.1% (placebo: 22.2%). ESL was more efficacious than placebo regardless of gender, geographical region, epilepsy duration, age at time of diagnosis, seizure type, and type of concomitant antiepileptic drugs (AED). Incidence of adverse events (AEs) and AEs leading to discontinuation was dose dependent. Most common AEs (>10% patients) were dizziness, somnolence, and nausea. The incidence of treatment-emergent AEs (dizziness, somnolence, ataxia, vomiting, and nausea) was lower in patients who began taking ESL 400 mg (followed by 400 mg increments to 800 or 1200 mg) than in those who began taking ESL 600 mg or 800 mg. Once-daily ESL 800 mg and 1200 mg showed consistent results across all efficacy and safety endpoints, independent of study population characteristics and type of concomitant AEDs. Treatment initiated with ESL 400 mg followed by 400 mg increments to 800 or 1200 mg provides optimal balance of efficacy and tolerability. © 2017 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.

School Context and the Effect ESL Placement on Mexican-Origin Adolescents’ Achievement*

PubMed Central

Callahan, Rebecca; Wilkinson, Lindsey; Muller, Chandra

2010-01-01

Objectives Immigrant adolescents’ academic achievement is crucial to our future economic stability, and Mexican-origin linguistic minority youth in U.S. schools generally demonstrate lower levels of achievement. English as a Second Language (ESL) programs provide an institutional response to these students’ needs, the effect of which may vary by the proportion of immigrant students in the school. Measures Using propensity score matching and data from the Adolescent Health and Academic Achievement Study (AHAA) and the National Longitudinal Study of Adolescent Health (Add Health), we estimate the effect of ESL placement on Mexican-origin achievement for first-, second-, and third-generation adolescents separately in schools with many and few immigrant students. Results The estimated effect of ESL placement varies by both immigrant concentration in the school and by students’ generational status. Conclusions We find that ESL enrollment may be protective for second-generation Mexican-origin adolescents in high immigrant concentration schools, and may prove detrimental for first-generation adolescents in contexts with few other immigrant students. PMID:20354570

School Context and the Effect ESL Placement on Mexican-Origin Adolescents' Achievement.

PubMed

Callahan, Rebecca; Wilkinson, Lindsey; Muller, Chandra

2008-01-01

OBJECTIVES: Immigrant adolescents' academic achievement is crucial to our future economic stability, and Mexican-origin linguistic minority youth in U.S. schools generally demonstrate lower levels of achievement. English as a Second Language (ESL) programs provide an institutional response to these students' needs, the effect of which may vary by the proportion of immigrant students in the school. MEASURES: Using propensity score matching and data from the Adolescent Health and Academic Achievement Study (AHAA) and the National Longitudinal Study of Adolescent Health (Add Health), we estimate the effect of ESL placement on Mexican-origin achievement for first-, second-, and third-generation adolescents separately in schools with many and few immigrant students. RESULTS: The estimated effect of ESL placement varies by both immigrant concentration in the school and by students' generational status. CONCLUSIONS: We find that ESL enrollment may be protective for second-generation Mexican-origin adolescents in high immigrant concentration schools, and may prove detrimental for first-generation adolescents in contexts with few other immigrant students.

Global probabilistic projections of extreme sea levels show intensification of coastal flood hazard.

PubMed

Vousdoukas, Michalis I; Mentaschi, Lorenzo; Voukouvalas, Evangelos; Verlaan, Martin; Jevrejeva, Svetlana; Jackson, Luke P; Feyen, Luc

2018-06-18

Global warming is expected to drive increasing extreme sea levels (ESLs) and flood risk along the world's coastlines. In this work we present probabilistic projections of ESLs for the present century taking into consideration changes in mean sea level, tides, wind-waves, and storm surges. Between the year 2000 and 2100 we project a very likely increase of the global average 100-year ESL of 34-76 cm under a moderate-emission-mitigation-policy scenario and of 58-172 cm under a business as usual scenario. Rising ESLs are mostly driven by thermal expansion, followed by contributions from ice mass-loss from glaciers, and ice-sheets in Greenland and Antarctica. Under these scenarios ESL rise would render a large part of the tropics exposed annually to the present-day 100-year event from 2050. By the end of this century this applies to most coastlines around the world, implying unprecedented flood risk levels unless timely adaptation measures are taken.

English-as-a-Second-Language Programs for Matriculated Students in the United States: An Exploratory Survey and Some Issues. Research Report. ETS RR-14-11

ERIC Educational Resources Information Center

Ling, Guangming; Wolf, Mikyung Kim; Cho, Yeonsuk; Wang, Yuan

2014-01-01

Although English-as-a-second-language (ESL) programs for matriculated students have been a presence in U.S. higher education since the 1940s, little has been documented in the literature concerning ESL courses, ESL placement tests, and the procedures in which incoming students are placed into appropriate classes.The present study takes three…

The Impact of Interface on ESL Reading Comprehension and Strategy Use: A Comparison of E-Books and Paper Texts

ERIC Educational Resources Information Center

Isaacson, Sarah A.

2017-01-01

The use of e-books in postsecondary education is projected to increase, yet many English as a second language (ESL) institutions have not yet incorporated e-books into their curricula, in part due to a dearth of research regarding their potential impacts on ESL reading comprehension and strategy use. This study fills a gap in the existing research…

The Navy’s Management of Software Licenses Needs Improvement

DTIC Science & Technology

2013-08-07

Enterprise Software Licensing ( ESL ) as a primary DON etliciency target. Through policy and Integrated Product Team actions, this efficiency...review, as well as with DoD Enterprise Software Initiative ( ESl ) Blanket Pw·chase Agreements and any r•elated fedeml Acquisition Regulation and General...organizational and multi-functional DON ESL team. The DON is also participating in DoD level enterprise softwru·e licensing project~ through the Dol

The Presence or Absence of Definiteness in the Native Language and Its Impact on ESL Learning

ERIC Educational Resources Information Center

Abu-Melhim Abdel-Rahman

2014-01-01

The purpose of this study was to determine if first language interference does play a significant role in the use of articles in English by native speakers of Arabic as compared to other ESL learners. An error analysis was conducted on the use of English articles in essays taken from two groups of advanced ESL learners. The essays were composed by…

From Welfare to Work: Dynamic Lesson Plans for ESL Learners. Final Report. Fiscal Year 1998-99 [and] From Welfare to Work: Lessons for ESL Learners.

ERIC Educational Resources Information Center

Center for Literacy, Inc., Philadelphia, PA.

This document combines a final project report and the resulting guidebook of 20 lesson plans for English as a second language (ESL) instructors to help learners work within the Temporary Assistance to Needy Families (TANF) system and acquire effective job readiness strategies, choose a career path, and pursue employment. The report describes the…

Educating Bilingual/ESL Teachers in a Language/Culture Exchange Field School: A Collaborative Model in Teacher Education.

ERIC Educational Resources Information Center

Guadarrama, Irma N.

This paper describes a program that brings bilingual and English-as-a-Second-Language (ESL) teachers from the United States to a Mexican ESL school to teach in the Tetiz (Yucatan, Mexico) field school and in exchange, learn Mayan language and culture. The theoretical base for the project is drawn from the work of major theorists in second language…

Eligibility and Programming in Chapter 1 E.S.L. Programs, 1987-88. Evaluation Section Report. End-of-Year Report. OREA Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; Stern, Lucia

This report profiles the utilization of funding by sites implementing Chapter 1/ Pupils with Compensatory Education Needs (PCEN) programs in English as a Second Language (ESL) in New York City schools, based on funding data and a district survey. Data for 83 high schools show that 23% of total allocations for ESL teachers were Chapter 1, 32% were…

Teaching ESL to Competencies: A Departure from a Traditional Curriculum for Adult Learners with Specific Needs. Adult Education Series #12. Refugee Education Guide.

ERIC Educational Resources Information Center

Center for Applied Linguistics, Washington, DC. Language and Orientation Resource Center.

Teaching English as a second language (ESL) to competencies requires that the instructional focus be on functional competencies and life-coping skills while developing the spoken and/or written English structures necessary to perform these skills. A step-by-step approach to develop and implement a competency-based approach to ESL for adults is…

Evaluation of a hepatitis B educational ESL curriculum for Chinese immigrants.

PubMed

Taylor, Victoria M; Teh, Chong; Lam, Wendy; Acorda, Elizabeth; Li, Lin; Coronado, Gloria; Yasui, Yutaka; Bajdik, Christopher; Hislop, Gregory

2009-01-01

According to recent census data, 1,216,600 Canadians are of Chinese descent, and over 80% of Chinese Canadians are foreign born. Approximately 10% of Chinese immigrants are chronic carriers of hepatitis B, compared with less than 0.5% of the general population. English as a second language (ESL) classes provide ready access for individuals with limited English proficiency who are not reached by English language health education materials and media campaigns. We conducted a group-randomized trial to evaluate the effectiveness of a hepatitis B ESL educational curriculum for Chinese immigrants. Five community-based organizations that provide ESL education in the greater Vancouver area participated in the study. Forty-one ESL classes (which included 325 Chinese students) were randomly assigned to experimental or control status. A follow-up survey, conducted six months after randomization, assessed knowledge about hepatitis B. Generalized estimating equations were used to analyze the data. Follow-up surveys were completed by 298 (92%) of the students. At follow-up, experimental group students were significantly (p < 0.05) more likely than control group students to know that immigrants have higher hepatitis B infection rates than people who were born in Canada; hepatitis B can be spread during childbirth, during sexual intercourse and by sharing razors; hepatitis B is not spread by sharing eating utensils; and hepatitis B infection can cause cirrhosis and liver cancer. Our findings indicate that ESL curricula can have a positive impact on health knowledge among Chinese immigrants with limited English. Future research should evaluate the effectiveness of ESL curricula for other immigrant groups, as well as other health topics.

Extreme sea levels on the rise along Europe's coasts

NASA Astrophysics Data System (ADS)

Vousdoukas, Michalis I.; Mentaschi, Lorenzo; Voukouvalas, Evangelos; Verlaan, Martin; Feyen, Luc

2017-03-01

Future extreme sea levels (ESLs) and flood risk along European coasts will be strongly impacted by global warming. Yet, comprehensive projections of ESL that include mean sea level (MSL), tides, waves, and storm surges do not exist. Here, we show changes in all components of ESLs until 2100 in view of climate change. We find that by the end of this century, the 100-year ESL along Europe's coastlines is on average projected to increase by 57 cm for Representative Concentration Pathways (RCP)4.5 and 81 cm for RCP8.5. The North Sea region is projected to face the highest increase in ESLs, amounting to nearly 1 m under RCP8.5 by 2100, followed by the Baltic Sea and Atlantic coasts of the UK and Ireland. Relative sea level rise (RSLR) is shown to be the main driver of the projected rise in ESL, with increasing dominance toward the end of the century and for the high-concentration pathway. Changes in storm surges and waves enhance the effects of RSLR along the majority of northern European coasts, locally with contributions up to 40%. In southern Europe, episodic extreme events tend to stay stable, except along the Portuguese coast and the Gulf of Cadiz where reductions in surge and wave extremes offset RSLR by 20-30%. By the end of this century, 5 million Europeans currently under threat of a 100-year ESL could be annually at risk from coastal flooding under high-end warming. The presented dataset is available through this link: http://data.jrc.ec.europa.eu/collection/LISCOAST.

Ultra-High Temperature Materials Characterization for Space and Missile Applications

NASA Technical Reports Server (NTRS)

Rogers, Jan; Hyers, Robert

2007-01-01

Numerous advanced space and missile technologies including propulsion systems require operations at high temperatures. Some very high-temperature materials are being developed to meet these needs, including refractory metal alloys, carbides, borides, and silicides. System design requires data for materials properties at operating temperatures. Materials property data are not available at the desired operating temperatures for many materials of interest. The objective of this work is to provide important physical property data at ultra-high temperatures. The MSFC Electrostatic Levitation (ESL) facility can provide measurements of thermophysical properties which include: creep strength, emissivity, density and thermal expansion. ESL uses electrostatic fields to position samples between electrodes during processing and characterization experiments. Samples float between the electrodes during studies and are free from any contact with a container or test apparatus. This provides a high purity environment for the study of high-temperature, reactive materials. ESL can be used to process a wide variety of materials including metals, alloys, ceramics, glasses and semiconductors. A system for the determination of total hemispherical emissivity is being developed for the MSFC ESL facility by AZ Technology Inc. The instrument has been designed to provide emissivity measurements for samples during ESL experiments over the temperature range 700-3400K. A novel non-contact technique for the determination of high-temperature creep strength has been developed. Data from selected ESL-based characterization studies will be presented. The ESL technique could advance space and missile technologies by advancing the knowledge base and the technology readiness level for ultra-high temperature materials. Applications include non-eroding nozzle materials and lightweight, high-temperature alloys for turbines and structures.

The groESL Chaperone Operon of Lactobacillus johnsonii†

PubMed Central

Walker, D. Carey; Girgis, Hany S.; Klaenhammer, Todd R.

1999-01-01

The Lactobacillus johnsonii VPI 11088 groESL operon was localized on the chromosome near the insertion element IS1223. The operon was initially cloned as a series of three overlapping PCR fragments, which were sequenced and used to design primers to amplify the entire operon. The amplified fragment was used as a probe to recover the chromosomal copy of the groESL operon from a partial library of L. johnsonii VPI 11088 (NCK88) DNA, cloned in the shuttle vector pTRKH2. The 2,253-bp groESL fragment contained three putative open reading frames, two of which encoded the ubiquitous GroES and GroEL chaperone proteins. Analysis of the groESL promoter region revealed three transcription initiation sites, as well as three sets of inverted repeats (IR) positioned between the transcription and translation start sites. Two of the three IR sets bore significant homology to the CIRCE elements, implicated in negative regulation of the heat shock response in many bacteria. Northern analysis and primer extension revealed that multiple temperature-sensitive promoters preceded the groESL chaperone operon, suggesting that stress protein production in L. johnsonii is strongly regulated. Maximum groESL transcription activity was observed following a shift to 55°C, and a 15 to 30-min exposure of log-phase cells to this temperature increased the recovery of freeze-thawed L. johnsonii VPI 11088. These results suggest that a brief, preconditioning heat shock can be used to trigger increased chaperone production and provide significant cross-protection from the stresses imposed during the production of frozen culture concentrates. PMID:10388700

The ROME (Retrospective Observational Multicenter study on Eslicarbazepine) study: Efficacy and behavioural effects of Eslicarbazepine acetate as adjunctive therapy for adults with partial onset seizures in real life.

PubMed

Assenza, G; Mecarelli, O; Lanzone, J; Assenza, F; Tombini, M; Di Lazzaro, V; Pulitano, P

2018-05-01

Eslicarbazepine acetate (ESL) is a third-generation member of the dibenzazepine family approved in 2009 by the European Medicines Agency with the indication of adjunctive therapy in adult people with partial-onset seizures (PPOS). We aimed at assessing the ESL impact on seizure frequency and quality of life in PPOS with a particular attention to sleepiness and depression. We evaluated 50 adult PPOS (>18 years; 48 ± 14 years-old; 23 males) treated with adjunctive ESL for ≥2months with a retrospective multi-centric design. Clinical files of the last 2 years were reviewed checking for monthly seizure frequency, treatment retention rate, adverse drug reactions (ADRs), concomitant anti-epileptic drugs and behavioural scales for sleepiness (Stanford Sleepiness Scale, SSS, and Epworth Sleepiness Scale, ESS), depression (Beck Depression Inventory-II, BDI) and overall quality of life (QOLIE-31). At the end of 96 ± 28 days of ESL treatment, the mean seizure reduction was 56%; 60% of patients had seizure reduction above 50%, with a 31% of the whole population becoming seizure free. We reported 16 ADRs with 4 hyponatremia. Retention rate was 76%. Patient reported less sleepiness after ESL (SSS, p = 0.031; ESS, p = 0.0000002). Before ESL, 38% of patients had pathologic BDI scores, which normalized in most of them (73%) after ESL (BDI improvement, p = 0.000012). These scores resulted in an amelioration of quality of life (QOLIE-31, p = 0.000002). ESL is a safe and effective anti-epileptic drug in a real life scenario, with an excellent behavioural profile for the overall quality of life and, in particular, for sleepiness and depression. Copyright © 2018 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Effects of two different feeding positions on physiological characteristics and feeding performance of preterm infants: A randomized controlled trial.

PubMed

Girgin, Burcu Aykanat; Gözen, Duygu; Karatekin, Güner

2018-04-01

The aim of this randomized controlled study was to determine the effect of semielevated side-lying (ESL) and semielevated supine (ESU) positions, which are used to bottle-feed preterm infants, on their physiological characteristics and feeding performance. The sample consisted of preterm infants who were born in the 31st gestational week and below, and met the inclusion criteria. A randomization was provided in the sample group with a total of 80 infants including 38 infants in the ESL (experimental) group and 42 infants in the ESU (control) group. Both groups were compared in terms of their SpO2 values, heart rates, and feeding performances before, during, and after the feeding. The data were obtained by using a form for infant descriptive characteristics, feeding follow-up form, a Masimo Radical-7 pulse oximeter device, and a video camera. It was determined that the infants in the ESL group had statistically significantly higher SpO2 values (ESL: 96.77 ± 2.51; ESU: 93.48 ± 5.63) and lower heart rates (ESL: 155.87 ± 11.18; ESU: 164.35 ± 6.00) during the feeding compared to the infants in the ESU group (p < .05). Besides, oxygen saturation levels of the infants in the ESU group decreased more (p < .01) and their heart rates increased more (p < .05) during the feeding than those obtained before the feeding compared to the infants in the ESL group. The ESL position has a more positive effect on oxygen saturation and heart rate of infants and it is more effective in providing a physiological stabilization during the feeding, compared to the ESU position. According to these results, the ESL position can be recommended for preterm feeding. © 2018 Wiley Periodicals, Inc.

A Learning Curriculum: Toward Student-Driven Pedagogy in the Context of Adult English for Academic Purposes, English for Specific Purposes, and Workplace English Programs

ERIC Educational Resources Information Center

Ananyeva, Maria

2014-01-01

This article introduces the concept of a learning curriculum that places adult English as a second language (ESL) students' needs in the center and encourages the engagement of ESL learners in curriculum design. The study is based on contemporary research in the field of adult ESL program planning. It summarizes key components of a learning…

Navy Force Structure and Shipbuilding Plans: Background and Issues for Congress

DTIC Science & Technology

2013-11-08

deferred repairs rise exponentially. The end result will be ships being decommissioned before their expected service life ( ESL ) due to degraded material...conduct routine operations, culminating in decommissioning ships before their ESL . Even when the trend is reversed and more funding is made available for...repair broken equipment and upgrade obsolete systems needed for deployment, and to ensure each ship reaches its ESL of thirty-five to forty years.23

New Beginnings: Ensuring Quality Bilingual/ESL Instruction in New York City Public Schools. Executive Summary [and] Report of the Chancellor's Bilingual/ESL Education Practitioners' Workgroup and Policy/Research Panels.

ERIC Educational Resources Information Center

New York City Board of Education, Brooklyn, NY. Office of Bilingual Education.

The report presents a conceptual framework and related strategies designed to help policymakers and practitioners re-examine, and when necessary, rework the basic assumptions and practices defining the educational experiences of bilingual/English-as-a-Second-Language (ESL) learners in New York City (New York) public schools. The report consists of…

Effects of adjunctive eslicarbazepine acetate on neurocognitive functioning in children with refractory focal-onset seizures.

PubMed

Jóźwiak, Sergiusz; Veggiotti, P; Moreira, J; Gama, H; Rocha, F; Soares-da-Silva, P

2018-04-01

This was a phase-II, randomized, double-blind (DB), placebo-controlled study aimed to evaluate neurocognitive effects of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset seizures (FOS). Children (6-16years old) with FOS were randomized (2:1) to ESL or placebo. Treatment started at 10mg/kg/day, was up-titrated up to 30mg/kg/day (target dose), and maintained for 8weeks, followed by one-year open-label follow-up. The primary endpoint was change from baseline to the end of maintenance period in the composite Power of Attention assessed with the Cognitive Drug Research (CDR) system. Behavioral and emotional functioning and quality of life (QOL), secondary endpoints, were assessed with Child Health Questionnaire-Parent Form 50 (CHQ-PF50), Child Behavior Checklist (CBCL), and Raven's Standard Progressive Matrices (SPM). Efficacy was evaluated through changes in standardized seizure frequency (SF), responder rate, and proportion of seizure-free patients. Safety was evaluated by the incidence of treatment-emergent adverse events (TEAEs). One hundred and twenty-three patients were randomized. A noninferiority analysis failed to reject the null hypothesis that the change from baseline in the Power of Attention score in the ESL group was at least 121ms inferior to the placebo group for all age groups. The CDR scores showed no differences between placebo and ESL in Power of Attention (1868.0 vs 1759.5), Continuity of Attention (1.136 vs -1.786), Quality of Working Memory (-0.023 vs -0.024), and Speed of Memory (-263.4 vs -249.6). Nonsignificant differences between placebo and ESL were seen for CHQ-PF50, CBCL scores, and Raven's SPM. Episodic Memory Index showed significant negative effect on ESL. Efficacy results favored the ESL group (SF least square [LS] means 1.98 vs 4.29). The TEAEs had a similar incidence between treatment groups (41.0% vs 47.5%). Overall ESL did not produce statistically significant effects on neurocognitive and behavioral functioning in patients with epilepsy aged 6 to 16years. Additionally, ESL was effective in reducing seizure frequency and was well-tolerated. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: a randomized historical-control phase III study based in North America.

PubMed

Sperling, Michael R; Harvey, Jay; Grinnell, Todd; Cheng, Hailong; Blum, David

2015-04-01

To assess the efficacy and safety of eslicarbazepine acetate (ESL) as monotherapy in North American patients with partial-onset seizures (POS). This multicenter, randomized, double-blind "withdrawal to monotherapy" study used historical control data as the comparator. Adults with POS medically uncontrolled by one to two antiepileptic drugs gradually converted to ESL monotherapy. Following an 8-week baseline period, patients were randomized 2:1 to receive ESL 1,600 mg (n = 128) or 1,200 mg QD (n = 65) for 18 weeks. The primary end point was the proportion of patients meeting predefined exit criteria (signifying worsening seizure control). Treatment was considered effective if the 95% upper confidence limit (UCL) for the Kaplan-Meier estimated exit rate was lower than the exit rate threshold calculated from the historical control (65.3%). Kaplan-Meier estimated exit rates were: ESL 1,600 mg, 28.7% (95% CI 21.2-38.1%) and 1,200 mg, 44.4% (32.5-58.3%). The difference between doses was not significant (p = 0.07). For both doses, the 95% UCLs for the exit rate were ˂ 65.3%; ESL monotherapy was considered superior to the historical control. There was no statistically significant increase in the risk of study exit related to carbamazepine use. Nine (7.6%) and five patients (8.3%) remained seizure-free during the 10-week monotherapy period, while taking ESL 1,600 and 1,200 mg, respectively. The reductions in median standardized seizure frequency (seizures per 28 days) between baseline and the 18-week treatment period were: ESL 1,600 mg, 42% and 1,200 mg, 31%. Treatment-emergent adverse events (TEAEs) occurring in ≥ 10% of patients were dizziness, headache, fatigue, somnolence, nausea, and nasopharyngitis. The TEAE most frequently leading to discontinuation was hyponatremia (2.1%). ESL was efficacious and well tolerated as monotherapy in North American patients, and led to a reduction in seizure frequency. Exit rates for ESL 1,600 and 1,200 mg QD were superior to the historical control; the difference in exit rates between doses was not statistically significant. © 2015 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy.

The discourse of causal explanations in school science

NASA Astrophysics Data System (ADS)

Slater, Tammy Jayne Anne

Researchers and educators working from a systemic functional linguistic perspective have provided a body of work on science discourse which offers an excellent starting point for examining the linguistic aspects of the development of causal discourse in school science, discourse which Derewianka (1995) claimed is critical to success in secondary school. No work has yet described the development of causal language by identifying the linguistic features present in oral discourse or by comparing the causal discourse of native and non-native (ESL) speakers of English. The current research responds to this gap by examining the oral discourse collected from ESL and non-ESL students at the primary and high school grades. Specifically, it asks the following questions: (1) How do the teachers and students in these four contexts develop causal explanations and their relevant taxonomies through classroom interactions? (2) What are the causal discourse features being used by the students in these four contexts to construct oral causal explanations? The findings of the social practice analysis showed that the teachers in the four contexts differed in their approaches to teaching, with the primary school mainstream teacher focusing largely on the hands-on practice , the primary school ESL teacher moving from practice to theory, the high school mainstream teacher moving from theory to practice, and the high school ESL teacher relying primarily on theory. The findings from the quantitative, small corpus approach suggest that the developmental path of cause which has been identified in the writing of experts shows up not only in written texts but also in the oral texts which learners construct. Moreover, this move appears when the discourse of high school ESL and non-ESL students is compared, suggesting a developmental progression in the acquisition of these features by these students. The findings also reveal that the knowledge constructed, as shown by the concept maps created from the discourse, follows a developmental path similar to the linguistic causal path, from the concrete, hands-on, observable items to more abstract, theoretical concepts. This study is the first systemic functional comparison of the oral discourse of primary and secondary learners as well as the first to compare ESL and non-ESL speakers in this way, and as such it helps map general trends in causal discourse development. (Abstract shortened by UMI.)

Implications Enzymatic Degradation of the Endothelial Glycocalyx on the Microvascular Hemodynamics and the Arteriolar Red Cell Free Layer of the Rat Cremaster Muscle.

PubMed

Yalcin, Ozlem; Jani, Vivek P; Johnson, Paul C; Cabrales, Pedro

2018-01-01

The endothelial glycocalyx is a complex network of glycoproteins, proteoglycans, and glycosaminoglycans; it lines the vascular endothelial cells facing the lumen of blood vessels forming the endothelial glycocalyx layer (EGL). This study aims to investigate the microvascular hemodynamics implications of the EGL by quantifying changes in blood flow hydrodynamics post-enzymatic degradation of the glycocalyx layer. High-speed intravital microscopy videos of small arteries (around 35 μm) of the rat cremaster muscle were recorded at various time points after enzymatic degradation of the EGL. The thickness of the cell free layer (CFL), blood flow velocity profiles, and volumetric flow rates were quantified. Hydrodynamic effects of the presence of the EGL were observed in the differences between the thickness of CFL in microvessels with an intact EGL and glass tubes of similar diameters. Maximal changes in the thickness of CFL were observed 40 min post-enzymatic degradation of the EGL. Analysis of the frequency distribution of the thickness of CFL allows for estimation of the thickness of the endothelial surface layer (ESL), the plasma layer, and the glycocalyx. Peak flow, maximum velocity, and mean velocity were found to statistically increase by 24, 27, and 25%, respectively, after enzymatic degradation of the glycocalyx. The change in peak-to-peak maximum velocity and mean velocity were found to statistically increase by 39 and 32%, respectively, after 40 min post-enzymatic degradation of the EGL. The bluntness of blood flow velocity profiles was found to be reduced post-degradation of the EGL, as the exclusion volume occupied by the EGL increased the effective volume impermeable to RBCs in microvessels. This study presents the effects of the EGL on microvascular hemodynamics. Enzymatic degradation of the EGL resulted in a decrease in the thickness of CFL, an increase in blood velocity, blood flow, and decrease of the bluntness of the blood flow velocity profile in small arterioles. In summary, the EGL functions as a molecular sieve to solute transport and as a lubrication layer to protect the endothelium from red blood cell (RBC) motion near the vessel wall, determining wall shear stress.

Effects of eslicarbazepine acetate on lipid profile and sodium levels in patients with epilepsy.

PubMed

Pulitano, Patrizia; Franco, Valentina; Mecarelli, Oriano; Brienza, Marianna; Davassi, Chiara; Russo, Emilio

2017-12-01

Several studies have demonstrated that treatment with enzyme-inducing antiepileptic drugs is associated with increased serum lipid levels. Eslicarbazepine acetate (ESL) is a novel antiepileptic drug specifically designed with the objective to identify carbamazepine and oxcarbazepine analogues with favorable pharmacodynamic and pharmacokinetic profiles. The present study aimed to assess the changes in lipid profile and sodium levels in patients with epilepsy taking ESL as adjunctive therapy. This report describes a retrospective cohort study of 36 adult patients with epilepsy, taking ESL as an add-on treatment. The laboratory values assessed prior and after (range 6-18 months) ESL treatment were sodium levels, total cholesterol (TC), low (LDL) and high (HDL) density lipoproteins and triglycerides. TC and LDL values were significantly decreased already after at least six months of therapy with ESL (191.3±29.6 vs 179.7±29.2mg/dl, p <0.0001 and 114.58±22.7 vs 103.11±19.46mg/dl, p <0.0001 respectively). HDL values before and during ESL treatment were significantly increased (57.5± 9.1 vs 63.9±8.3mg/dl; p<0.0001). No statistically significant changes have been found in triglycerides and sodium values. Add-on therapy with ESL, in contrast to the negative effects observed with traditional older carboxamides, positively affects lipid metabolism profile in patients with epilepsy over an average follow-up of 11 months. Further research is needed to confirm the obtained results with a focus on a comprehensive assessment of the biochemical and molecular mechanisms involved. Copyright © 2017 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Exposure-safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate.

PubMed

Gidal, B E; Jacobson, M P; Ben-Menachem, E; Carreño, M; Blum, D; Soares-da-Silva, P; Falcão, A; Rocha, F; Moreira, J; Grinnell, T; Ludwig, E; Fiedler-Kelly, J; Passarell, J; Sunkaraneni, S

2018-05-06

Eslicarbazepine acetate (ESL) is a once-daily (QD) oral antiepileptic drug (AED) for focal-onset seizures (FOS). Pharmacokinetic (PK) and pharmacodynamic (PD) models were developed to assess dose selection, identify significant AED drug interactions, and quantitate relationships between exposure and safety and efficacy outcomes from Phase 3 trials of adjunctive ESL. Eslicarbazepine (the primary active metabolite of ESL) population PK was evaluated using data from 1351 subjects enrolled in 14 studies (11 Phase 1 and three Phase 3 studies) after multiple oral doses ranging from 400 to 1200 mg. Population PK and PD models related individual eslicarbazepine exposures to safety outcomes and efficacy responses. Eslicarbazepine PK was described by a one-compartment model with linear absorption and elimination. The probability of a treatment-emergent adverse event (TEAE; dizziness, headache, or somnolence) was higher with an initial dose of ESL 800 mg than with an initial dose of ESL 400 mg QD. Body weight, sex, region, and baseline use of carbamazepine (CBZ) or lamotrigine were also found to influence the probability of TEAEs. Eslicarbazepine exposure influenced serum sodium concentration, standardized seizure frequency, and probability of response; better efficacy outcomes were predicted in patients not from Western Europe (WE; vs WE patients) and those not taking CBZ (vs taking CBZ) at baseline. Pharmacokinetic and PK/PD modeling were implemented during the development of ESL for adjunctive treatment of FOS in adults. This quantitative approach supported decision-making during the development of ESL, and contributed to dosing recommendations and labeling information related to drug interactions. © 2018 The Authors. Acta Neurologica Scandinavica Published by John Wiley & Sons Ltd.

Evaluation of a Hepatitis B Educational ESL Curriculum for Chinese Immigrants

PubMed Central

Taylor, Victoria M.; Teh, Chong; Lam, Wendy; Acorda, Elizabeth; Li, Lin; Coronado, Gloria; Yasui, Yutaka; Bajdik, Christopher; Hislop, Gregory

2010-01-01

Objectives According to recent census data, 1,216,600 Canadians are of Chinese descent, and over 80% of Chinese Canadians are foreign born. Approximately 10% of Chinese immigrants are chronic carriers of hepatitis B, compared with less than 0.5% of the general population. English as a second language (ESL) classes provide ready access for individuals with limited English proficiency who are not reached by English language health education materials and media campaigns. We conducted a group-randomized trial to evaluate the effectiveness of a hepatitis B ESL educational curriculum for Chinese immigrants. Methods Five community-based organizations that provide ESL education in the greater Vancouver area participated in the study. Forty-one ESL classes (which included 325 Chinese students) were randomly assigned to experimental or control status. A follow-up survey, conducted six months after randomization, assessed knowledge about hepatitis B. Generalized estimating equations were used to analyze the data. Results Follow-up surveys were completed by 298 (92%) of the students. At follow-up, experimental group students were significantly (p<0.05) more likely than control group students to know that immigrants have higher hepatitis B infection rates than people who were born in Canada; hepatitis B can be spread during childbirth, during sexual intercourse and by sharing razors; hepatitis B is not spread by sharing eating utensils; and hepatitis B infection can cause cirrhosis and liver cancer. Conclusion Our findings indicate that ESL curricula can have a positive impact on health knowledge among Chinese immigrants with limited English. Future research should evaluate the effectiveness of ESL curricula for other immigrant groups, as well as other health topics. PMID:20209742

Euro-Esli: a European audit of real-world use of eslicarbazepine acetate as a treatment for partial-onset seizures.

PubMed

Villanueva, Vicente; Holtkamp, Martin; Delanty, Norman; Rodriguez-Uranga, Juan; McMurray, Rob; Santagueda, Patricia

2017-11-01

The Euro-Esli study was an exploratory pooled analysis of data from 14 European clinical practice studies, which was conducted to audit the real-world effectiveness, safety, and tolerability of eslicarbazepine acetate (ESL) as an adjunctive treatment for partial-onset seizures. Retention and effectiveness were assessed after 3, 6, and 12 months of ESL treatment, and at the final visit. Safety and tolerability were assessed throughout ESL treatment by evaluating adverse events (AEs) and ESL discontinuation due to AEs. Data from 2058 patients (52.1% male; mean age 44.0 years) were included. All 2058 patients were assessed for safety and 1975 (96.0%) patients were assessed for effectiveness. After 12 months, retention, responder (≥50% seizure frequency reduction), and seizure freedom rates were 73.4, 75.6, and 41.3%, respectively. AEs were reported for 34.0% of patients and led to discontinuation in 13.6% of patients. The most frequently reported AEs were dizziness (6.7% of patients), fatigue (5.4%), and somnolence (5.1%). No unexpected safety signals emerged over a median duration of follow-up of >5 years. Subgroup analyses revealed that ESL was significantly more effective in patients aged ≥65 versus <65 years, in patients who were not receiving treatment with other sodium channel blockers versus those who were receiving treatment with other sodium channel blockers, and in patients who were receiving <2 versus ≥2 concomitant antiepileptic drugs at baseline. Euro-Esli is the largest ESL clinical practice study conducted to date. This study provides strong and reassuring evidence of ESL's safety profile, and complements the data from clinical trials.

EPICON consensus: recommendations for proper management of switching to eslicarbazepine acetate in epilepsy.

PubMed

Villanueva, V; Ojeda, J; Rocamora, R A; Serrano-Castro, P J; Parra, J; Rodríguez-Uranga, J J; Bathal, H; Viteri, C

2018-06-01

The objective of the EPICON Project is to develop a set of recommendations on how to adequately switch from carbamazepine (CBZ) and oxcarbazepine (OXC) to eslicarbazepine acetate (ESL) in some patients with epilepsy. A steering committee drafted a questionnaire of 56 questions regarding the transition from CBZ or OXC to ESL in clinical practice (methodology and change situation). The questionnaire was then distributed to 54 epilepsy experts in 2 rounds using the Delphi method. An agreement/disagreement consensus was defined when a median ≥ 7 points or ≤ 3 was achieved, respectively, and a relative interquartile range ≤ 0.40. We analysed the results obtained to reach our conclusions. Our main recommendations were the following: switching from CBZ to ESL must be carried out over a period of 1 to 3 weeks with a CBZ:ESL dose ratio of 1:1.3 and is recommended for patients who frequently forget to take their medication, those who work rotating shifts, polymedicated patients, subjects with cognitive problems, severe osteoporosis-osteopaenia, dyslipidaemia, or liver disease other than acute liver failure, as well as for men with erectile dysfunction caused by CBZ. The transition from OXC to ESL can take place overnight with an OXC:ESL dose ratio of 1:1 and it is recommended for patients who frequently forget to take their medication, those who work rotating shifts, polymedicated patients, or those with cognitive problems. The transition was not recommended for patients with prior rash due to CBZ or OXC use. The EPICON Project offers a set of recommendations about the clinical management of switching from CBZ or OXC to ESL, using the Delphi method. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Effective side length formula for resonant frequency of equilateral triangular microstrip antenna

NASA Astrophysics Data System (ADS)

Guney, Kerim; Kurt, Erhan

2016-02-01

A novel and accurate expression is obtained by employing the differential evolution algorithm for the effective side length (ESL) of the equilateral triangular microstrip antenna (ETMA). This useful formula allows the antenna engineers to accurately calculate the ESL of the ETMA. The computed resonant frequencies (RFs) show very good agreement with the experimental RFs when this accurate ESL formula is utilised for the computation of the RFs for the first five modes.

A Comparative Study of the Complaint Strategies among Iranian EFL and ESL Students--The Study of the Effect of Length of Residence and the Amount of Contact

ERIC Educational Resources Information Center

Mofidi, Marzieh; Shoushtari, Zohreh Gooniband

2012-01-01

The purpose of this study was to investigate the pragmatic transfer Iranian EFL and ESL learners of English showed when complaining in English. The study aimed to find out if there exists any relationship between the amount of contact with English and pragmatic competence of both EFL and ESL groups as well as the relationship between the duration…

Emergency Immigration Education Act Programs: Summer E.S.L. Welcome Plus Program for Students of Limited English Proficiency (LEP), Summer Bilingual Program, and Project Omega. OREA Report.

ERIC Educational Resources Information Center

Duque, Diana L.

This report presents findings of the evaluation by the New York City public school system's Office of Research, Evaluation, and Assessment of three programs (Summer E.S.L. Welcome Plus, Summer Bilingual, and Project Omega) for immigrant students. The Summer E.S.L. (English as a Second Language) Welcome Plus program operated at 19 sites in New York…

Expanding Learning and Teaching Processes in an ESL/Civics ABE Classroom Using an Interactive Video Lesson Plan in the U.S. Southwest: An Action Research Study

ERIC Educational Resources Information Center

Cajar-Bravo, Aristides

2010-01-01

This study is an action research project that analyzed the ways in which ESL students improve their language learning processes by using as a teaching tool a media literacy video and Civics Education for social skills; it was presented to two groups of 12 students who were attending an ESL/Civics Education Intermediate-Advanced class in an ABE…

A Teacher’s Guide for Using Learning Strategies in English-as-a-Second- Language Instruction

DTIC Science & Technology

1984-11-01

learner strategies used in the acquisition of English as a second language (ESL). The Teacher’s Guide demonstrates for ESL...strategies to apply to a wide range of language learning tasks are far more likely to be effective language learners . The language lessons in this section...skills in the acquisition of English as a second language (ESL). This study completed a review of the literature on learning strategies in

Electrical source localization by LORETA in patients with epilepsy: Confirmation by postoperative MRI

PubMed Central

Akdeniz, Gülsüm

2016-01-01

Background: Few studies have been conducted that have compared electrical source localization (ESL) results obtained by analyzing ictal patterns in scalp electroencephalogram (EEG) with the brain areas that are found to be responsible for seizures using other brain imaging techniques. Additionally, adequate studies have not been performed to confirm the accuracy of ESL methods. Materials and Methods: In this study, ESL was conducted using LORETA (Low Resolution Brain Electromagnetic Tomography) in 9 patients with lesions apparent on magnetic resonance imaging (MRI) and in 6 patients who did not exhibit lesions on their MRIs. EEGs of patients who underwent surgery for epilepsy and had follow-ups for at least 1 year after operations were analyzed for ictal spike, rhythmic, paroxysmal fast, and obscured EEG activities. Epileptogenic zones identified in postoperative MRIs were then compared with localizations obtained by LORETA model we employed. Results: We found that brain areas determined via ESL were in concordance with resected brain areas for 13 of the 15 patients evaluated, and those 13 patients were post-operatively determined as being seizure-free. Conclusion: ESL, which is a noninvasive technique, may contribute to the correct delineation of epileptogenic zones in patients who will eventually undergo surgery to treat epilepsy, (regardless of neuroimaging status). Moreover, ESL may aid in deciding on the number and localization of intracranial electrodes to be used in patients who are candidates for invasive recording. PMID:27011626

Electrical source localization by LORETA in patients with epilepsy: Confirmation by postoperative MRI.

PubMed

Akdeniz, Gülsüm

2016-01-01

Few studies have been conducted that have compared electrical source localization (ESL) results obtained by analyzing ictal patterns in scalp electroencephalogram (EEG) with the brain areas that are found to be responsible for seizures using other brain imaging techniques. Additionally, adequate studies have not been performed to confirm the accuracy of ESL methods. In this study, ESL was conducted using LORETA (Low Resolution Brain Electromagnetic Tomography) in 9 patients with lesions apparent on magnetic resonance imaging (MRI) and in 6 patients who did not exhibit lesions on their MRIs. EEGs of patients who underwent surgery for epilepsy and had follow-ups for at least 1 year after operations were analyzed for ictal spike, rhythmic, paroxysmal fast, and obscured EEG activities. Epileptogenic zones identified in postoperative MRIs were then compared with localizations obtained by LORETA model we employed. We found that brain areas determined via ESL were in concordance with resected brain areas for 13 of the 15 patients evaluated, and those 13 patients were post-operatively determined as being seizure-free. ESL, which is a noninvasive technique, may contribute to the correct delineation of epileptogenic zones in patients who will eventually undergo surgery to treat epilepsy, (regardless of neuroimaging status). Moreover, ESL may aid in deciding on the number and localization of intracranial electrodes to be used in patients who are candidates for invasive recording.

Development of an ESL curriculum to educate Chinese immigrants about physical activity.

PubMed

Taylor, Victoria M; Cripe, Swee May; Acorda, Elizabeth; Teh, Chong; Coronado, Gloria; Do, Hoai; Woodall, Erica; Hislop, T Gregory

2008-08-01

Regular physical activity reduces the risk of many chronic conditions. Multiple studies have shown that Asians in North America engage in less physical activity than the general population. One area for strategic development in the area of health education is the design and evaluation of English as a second language (ESL) curricula. The PRECEDE model and findings from focus groups were used to develop a physical activity ESL curriculum for Chinese immigrants. In general, focus group participants recognized that physical activity contributes to physical and mental wellbeing. However, the benefits of physical activity were most commonly described in terms of improved blood circulation, immune responses, digestion, and reflexes. The importance of peer pressure and the encouragement of friends in adhering to regular physical activity regimens were mentioned frequently. Reported barriers to regular physical activity included lack of time, weather conditions, and financial costs. The ESL curriculum aims to both promote physical activity and improve knowledge, and includes seven different ESL exercises. Our curriculum development methods could be replicated for other health education topics and in other limited English-speaking populations.

DEVELOPMENT OF AN ESL CURRICULUM TO EDUCATE CHINESE IMMIGRANTS ABOUT PHYSICAL ACTIVITY

PubMed Central

Taylor, Victoria M.; Cripe, Swee May; Acorda, Elizabeth; Teh, Chong; Coronado, Gloria; Do, Hoai; Woodall, Erica; Hislop, T. Gregory

2009-01-01

Regular physical activity reduces the risk of many chronic conditions. Multiple studies have shown that Asians in North America engage in less physical activity than the general population. One area for strategic development in the area of health education is the design and evaluation of English as a second language (ESL) curricula. The PRECEDE model and findings from focus groups were used to develop a physical activity ESL curriculum for Chinese immigrants. In general, focus group participants recognized that physical activity contributes to physical and mental wellbeing. However, the benefits of physical activity were most commonly described in terms of improved blood circulation, immune responses, digestion, and reflexes. The importance of peer pressure and the encouragement of friends in adhering to regular physical activity regimens were mentioned frequently. Reported barriers to regular physical activity included lack of time, weather conditions, and financial costs. The ESL curriculum aims to both promote physical activity and improve knowledge, and includes seven different ESL exercises. Our curriculum development methods could be replicated for other health education topics and in other limited English-speaking populations. PMID:17943444

Beamline Electrostatic Levitator (BESL) for in-situ High Energy K-Ray Diffraction Studies of Levitated Solids and Liquids at High Temperature

NASA Technical Reports Server (NTRS)

Gangopadhyay, A. K.; Lee, G. W.; Kelton, K. F.; Rogers, J. R.; Goldman, A. I.; Robinson, D. S.; Rathz, T. J.; Hyers, R. W.

2005-01-01

Determinations of the phase formation sequence, the crystal structures and the thermodynamic properties of materials at high temperatures are difficult because of contamination from the sample container and environment. Containerless processing techniques, such as electrostatic (ESL), electromagnetic (EML), aerodynamic, and acoustic levitation, are most suitable these studies. An adaptation of ESL for in-situ structural studies of a wide range of materials, including metals, semiconductors, insulators using high energy (125 keV) synchrotron x-rays is described here. This beamline ESL (BESL) allows the in-situ determination of the atomic structures of equilibrium solid and liquid phases, including undercooled liquids, as well as real-time studies of solid-solid and liquid-solid phase transformations. The use of image plate (MAR345) or GE-Angio detectors enables fast (30 ms - 1s) acquisition of complete diffraction patterns over a wide q-range (4 - 140/mm). The wide temperature range (300 - 2500 K), containerless processing under high vacuum (10(exp -7) - 10(exp -8) torr), and fast data acquisition, make BESL particularly suitable for phase diagram studies of high temperature materials. An additional, critically important, feature of BESL is the ability to also make simultaneous measurement of a host of thermo-physical properties, including the specific heat, enthalpy of transformation, solidus and liquidus temperatures, density, viscosity, and surface tension; all on the same sample and simultaneous with the structural measurements.

The Behaviour of Naturally Debonded Composites Due to Bending Using a Meso-Level Model

NASA Astrophysics Data System (ADS)

Lord, C. E.; Rongong, J. A.; Hodzic, A.

2012-06-01

Numerical simulations and analytical models are increasingly being sought for the design and behaviour prediction of composite materials. The use of high-performance composite materials is growing in both civilian and defence related applications. With this growth comes the necessity to understand and predict how these new materials will behave under their exposed environments. In this study, the displacement behaviour of naturally debonded composites under out-of-plane bending conditions has been investigated. An analytical approach has been developed to predict the displacement response behaviour. The analytical model supports multi-layered composites with full and partial delaminations. The model can be used to extract bulk effective material properties in which can be represented, later, as an ESL (Equivalent Single Layer). The friction between each of the layers is included in the analytical model and is shown to have distinct behaviour for these types of composites. Acceptable agreement was observed between the model predictions, the ANSYS finite element model, and the experiments.

Design, fabrication and characterization of LTCC-based electromagnetic microgenerators

NASA Astrophysics Data System (ADS)

Gierczak, M.; Markowski, P.; Dziedzic, A.

2016-02-01

Design, manufacturing process and properties of electromagnetic microgenerators fabricated in LTCC (Low Temperature Co-fired Ceramics) technology are presented in this paper. Electromagnetic microgenerators consist of planar coils spatially arranged on several layers of LTCC and of a multipole permanent magnet. Two different patterns of coils with 2-, 8-,10- and 12-layers and outer diameter of 50 mm were designed and fabricated. Silver-based pastes ESL 903-A or DuPont 6145 were used. In order to estimate the inductance of a single spatial coil the Greenhouse (self-inductance) and Hoer (mutual inductance) calculation methods were used. To verify the calculation results a single-layer coil was fabricated for each pattern and its inductance was measured using the precision RLC Meter. Fabricated LTCC microgenerators with embedded coils allow to generate voltage higher than ten volts and the electrical output power of approximately 600 mW at the rotor rotation speed of 12 thousands rpm. The self-made system was used for characterization of LTCC-based electromagnetic microgenerators.

Six principles of language development: implications for second language learners.

PubMed

Konishi, Haruka; Kanero, Junko; Freeman, Max R; Golinkoff, Roberta Michnick; Hirsh-Pasek, Kathy

2014-01-01

The number of children growing up in dual language environments is increasing in the United States. Despite the apparent benefits of speaking two languages, children learning English as a second language (ESL) often face struggles, as they may experience poverty and impoverished language input at home. Early exposure to a rich language environment is crucial for ESL children's academic success. This article explores how six evidenced-based principles of language learning can be used to provide support for ESL children.

The Iron Triangle Manifested: U.S. Air Force Tanker Lease 2001-2005 Case Study

DTIC Science & Technology

2012-01-01

own experts along with participants from Boeing and Rockwell to perform the KC–135 Economic Service Life Study ( ESLS ). Based on usage at that time...General John D. Ryan stated a replacement program would start in the next 15 years.9 2 Punjani The ESLS pre-dated 9/11 and did not account for...increased flight hours due to homeland defense air patrols and the war in Afghanistan. Usage rates increased from the ESLS -report- ed figure of 308 hours per

28 CFR 544.43 - Incentives.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Mandatory English-as-a-Second Language Program (ESL) § 544.43 Incentives. The Warden or designee shall establish a system of incentives to encourage an inmate to meet the mandatory ESL program requirements. ...

Saussurea lappa extract suppresses TPA-induced cell invasion via inhibition of NF-κB-dependent MMP-9 expression in MCF-7 breast cancer cells

PubMed Central

2014-01-01

Background Saussurea lappa (SL) has been used as a traditional herbal medicine to treat abdominal pain and tenesmus, and has been suggested to possess various biological activities, including anti-tumor, anti-ulcer, anti-inflammatory, anti-viral, and cardiotonic activities. The effect of SL on breast cancer metastasis, however, is unknown. Cell migration and invasion are crucial in neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is a major component in cancer cell invasion. Methods Cell viability was examined by MTT assay, whereas cell motility was measured by invasion assay. Western blot, Real-time PCR, and Zymography assays were used to investigate the inhibitory effects of ESL on matrix metalloproteinase-9 (MMP-9) expression level in MCF-7 cells. EMSA confirmed the inhibitory effects of ESL on DNA binding of NF- κB in MCF-7 cells. Results Cells threated with various concentrations of Saussurea lappa (ESL) for 24 h. Concentrations of 2 or 4 μM did not lead to a significant change in cell viability or morphology. Therefore, subsequent experiments utilized the optimal non-toxic concentration (2 or 4 μM) of ESL. In this study, we investigated the inhibitory effect of ethanol extract of ESL on MMP-9 expression and cell invasion in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MCF-7 cells. ESL inhibited the TPA-induced transcriptional activation of nuclear factor-kappa B (NF-κB). However, this result obtained that ESL did not block the TPA-induced phosphorylation of the kinases: p38, ERK, and JNK. Therefore, ELS-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-kB pathway in MCF-7 cells. Conclusions These results indicate that ELS-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-kB pathway in MCF-7 cells. Thus, ESL has potential for controlling breast cancer invasiveness in vitro. PMID:24885456

Analyzing extreme sea levels for broad-scale impact and adaptation studies

NASA Astrophysics Data System (ADS)

Wahl, T.; Haigh, I. D.; Nicholls, R. J.; Arns, A.; Dangendorf, S.; Hinkel, J.; Slangen, A.

2017-12-01

Coastal impact and adaptation assessments require detailed knowledge on extreme sea levels (ESL), because increasing damage due to extreme events is one of the major consequences of sea-level rise (SLR) and climate change. Over the last few decades, substantial research efforts have been directed towards improved understanding of past and future SLR; different scenarios were developed with process-based or semi-empirical models and used for coastal impact studies at various temporal and spatial scales to guide coastal management and adaptation efforts. Uncertainties in future SLR are typically accounted for by analyzing the impacts associated with a range of scenarios and model ensembles. ESL distributions are then displaced vertically according to the SLR scenarios under the inherent assumption that we have perfect knowledge on the statistics of extremes. However, there is still a limited understanding of present-day ESL which is largely ignored in most impact and adaptation analyses. The two key uncertainties stem from: (1) numerical models that are used to generate long time series of storm surge water levels, and (2) statistical models used for determining present-day ESL exceedance probabilities. There is no universally accepted approach to obtain such values for broad-scale flood risk assessments and while substantial research has explored SLR uncertainties, we quantify, for the first time globally, key uncertainties in ESL estimates. We find that contemporary ESL uncertainties exceed those from SLR projections and, assuming that we meet the Paris agreement, the projected SLR itself by the end of the century. Our results highlight the necessity to further improve our understanding of uncertainties in ESL estimates through (1) continued improvement of numerical and statistical models to simulate and analyze coastal water levels and (2) exploit the rich observational database and continue data archeology to obtain longer time series and remove model bias. Finally, ESL uncertainties need to be integrated with SLR uncertainties. Otherwise, important improvements in providing more robust SLR projections are of less benefit for broad-scale impact and adaptation studies and decision processes.

20 CFR 638.502 - Job Corps basic education program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... as a second language (ESL) programs for selected center operators (regional offices shall arrange for the assignment of selected applicants needing ESL programs to the centers where such programs are...

28 CFR 544.40 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Mandatory English-as-a-Second Language Program (ESL) § 544.40 Purpose and scope. Pursuant to the Crime... Prisons institutions are required to attend an English-as-a-Second Language (ESL) program until they...

Titanium-Zirconium-Nickel Alloy Inside Marshall's Electrostatic Levitator (ESL)

NASA Technical Reports Server (NTRS)

2003-01-01

This is a close-up of a sample of titanium-zirconium-nickel alloy inside the Electrostatic Levitator (ESL) vacuum chamber at NASA's Marshall Space Flight Center (MSFC). The ESL uses static electricity to suspend an object (about 3-4 mm in diameter) inside a vacuum chamber allowing scientists to record a wide range of physical properties without the sample contracting the container or any instruments, conditions that would alter the readings. Once inside the chamber, a laser heats the sample until it melts. The laser is then turned off and the sample cools, changing from a liquid drop to a solid sphere. Since 1977, the ESL has been used at MSFC to study the characteristics of new metals, ceramics, and glass compounds. Materials created as a result of these tests include new optical materials, special metallic glasses, and spacecraft components.

E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion.

PubMed

Yamamoto, Hiroyasu; Kuroda, Nana; Uekita, Hiromi; Kochi, Ikoi; Matsumoto, Akane; Niinaga, Ryu; Funahashi, Tohru; Shimomura, Iichiro; Kihara, Shinji

2016-02-05

Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. In this study, we identified E-selectin ligand (ESL)-1 as a novel APN-binding protein by mass spectrometry analysis of HepG2 cell-derived immunoprecipitant with an anti-APN antibody. Cell adhesion assays using fluorescence-labelled monocyte cell line THP-1 cells and human umbilical vein endothelial cells (HUVECs) revealed that APN-pre-treated THP-1 cells had reduced binding ability to HUVECs. This APN-mediated suppressive effect on monocyte binding to endothelial cells was partially abrogated by targeting ESL-1 with shRNA in THP-1 cells. In addition, serial mutagenesis analysis disclosed that five extracellular amino acids close to the N-terminus of ESL-1 were essential for binding with APN. Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. Copyright © 2016 Elsevier Inc. All rights reserved.

Amplification of the groESL operon in Pseudomonas putida increases siderophore gene promoter activity.

PubMed

Venturi, V; Wolfs, K; Leong, J; Weisbeek, P J

1994-10-17

Pseudobactin 358 is the yellow-green fluorescent siderophore [microbial iron(III) transport agent] produced by Pseudomonas putida WCS358 under iron-limiting conditions. The genes encoding pseudobactin 358 biosynthesis are iron-regulated at the level of transcription. In this study, the molecular characterization is reported of a cosmid clone of WCS358 DNA that can stimulate, in an iron-dependent manner, the activity of a WCS358 siderophore gene promoter in the heterologous Pseudomonas strain A225. The functional region in the clone was identified by subcloning, transposon mutagenesis and DNA sequencing as the groESL operon of strain WCS358. This increase in promoter activity was not observed when the groESL genes of strain WCS358 were integrated via a transposon vector into the genome of Pseudomonas A225, indicating that multiple copies of the operon are necessary for the increase in siderophore gene promoter activity. Amplification of the Escherichia coli and WCS358 groESL genes also increased iron-regulated promoter activity in the parent strain WCS358. The groESL operon codes for the chaperone proteins GroES and GroEL, which are responsible for mediating the folding and assembly of many proteins.

Non-contact Creep Resistance Measurement for Ultra-High Temperature Materials

NASA Technical Reports Server (NTRS)

Lee, J.; Bradshaw, C.; Rogers, J. R.; Rathz, T. J.; Wall, J. J.; Choo, H.; Liaw, P. K.; Hyers, R. W.

2005-01-01

Conventional techniques for measuring creep are limited to about 1700 C, so a new technique is required for higher temperatures. This technique is based on electrostatic levitation (ESL) of a spherical sample, which is rotated quickly enough to cause creep deformation by centrifugal acceleration. Creep of samples has been demonstrated at up to 2300 C in the ESL facility at NASA MSFC, while ESL itself has been applied at over 3000 C, and has no theoretical maximum temperature. The preliminary results and future directions of this NASA-funded research collaboration will be presented.

Eslicarbazepine acetate add-on for drug-resistant partial epilepsy.

PubMed

Chang, Xian-Chao; Yuan, Hai; Wang, Yi; Xu, Hui-Qin; Hong, Wen-Ke; Zheng, Rong-Yuan

2017-10-25

This is an updated version of the Cochrane Review published in the Cochrane Library 2011, Issue 12.The majority of people with epilepsy have a good prognosis, but up to 30% of people continue to have seizures despite several regimens of antiepileptic drugs. In this review, we summarized the current evidence regarding eslicarbazepine acetate (ESL) when used as an add-on treatment for drug-resistant partial epilepsy. To evaluate the efficacy and tolerability of ESL when used as an add-on treatment for people with drug-resistant partial epilepsy. The searches for the original review were run in November 2011. Subsequently, we searched the Cochrane Epilepsy Group Specialized Register (6 December 2016), the Cochrane Central Register of Controlled Trials (CENTRAL 2016, Issue 11) and MEDLINE (1946 to 6 December 2016). There were no language restrictions. We reviewed the reference lists of retrieved studies to search for additional reports of relevant studies. We also contacted the manufacturers of ESL and experts in the field for information about any unpublished or ongoing studies. Randomized placebo controlled double-blind add-on trials of ESL in people with drug-resistant partial epilepsy. Two review authors independently selected trials for inclusion and extracted data. Outcomes investigated included 50% or greater reduction in seizure frequency, seizure freedom, treatment withdrawal, adverse effects, and drug interactions. Primary analyses were by intention to treat (ITT). The dose-response relationship was evaluated in regression models. We included five trials (1799 participants) rated at low risk of bias; all studies were funded by BIAL. The overall risk ratio (RR) with 95% confidence interval (CI) for 50% or greater reduction in seizure frequency was 1.71 (95% CI 1.42 to 2.05). Dose regression analysis showed evidence that ESL reduced seizure frequency with an increase in efficacy with increasing doses of ESL. ESL was significantly associated with seizure freedom (RR 2.90, 95% CI 1.49 to 5.68). Participants were more likely to have ESL withdrawn for adverse effects (RR 2.66, 95% CI 1.42 to 4.96) but not for any reason (RR 1.19, 95% CI 0.86 to 1.64). The following adverse effects were significantly associated with ESL: dizziness (RR 2.81, 99% CI 1.86 to 4.27); nausea (RR 2.61, 99% CI 1.36 to 5.01); diplopia (RR 4.14, 99% CI 1.74 to 9.84); somnolence (RR 1.71, 99% CI 1.11 to 2.63) and vomiting (RR 3.30, 99% CI 1.34 to 8.13). Overall the quality of the evidence was rated as moderate to high. ESL reduces seizure frequency when used as an add-on treatment for people with drug-resistant partial epilepsy. The trials included in this review were of short-term duration and focused on adults. One new trial has been included in this update, but the conclusions are unchanged.

Efficacy and safety of eslicarbazepine acetate monotherapy for partial-onset seizures: Experience from a multicenter, observational study.

PubMed

Toledano, Rafael; Jovel, Camilo Espinosa; Jiménez-Huete, Adolfo; Bayarri, Pau Giner; Campos, Dulce; Gomariz, Elena López; Giráldez, Beatriz González; García-Morales, Irene; Falip, Mercé; Agredano, Paula Martínez; Palao, Susana; Prior, María José Aguilar Amat; Pascual, María Rosa Querol; Navacerrada, Francisco José; González, Francisco Javier López; Ojeda, Joaquín; Sáez, Aránzazu Alfaro; Bermejo, Pedro Emilio; Gil-Nagel, Antonio

2017-08-01

Eslicarbazepine acetate (ESL, Aptiom™) is a once-daily anticonvulsant, approved as adjunctive treatment of partial-onset seizures (POS). Historical-controlled trials investigating the use of ESL as monotherapy have demonstrated a favorable efficacy and tolerability profile in patients with POS. This prospective, non-interventional study recruited POS patients in 17 hospitals in Spain. After a 3-month baseline period, ESL therapy was initiated as 400mg QD and up-titrated to an optimal maintenance dose based on clinical response and tolerance. The incidence of seizures was assessed via seizure calendars and the nature and severity of adverse events (AEs) were also recorded. A total of 117 patients (aged 9-87years) enrolled in the study and were treated with ESL at either 400mg/day (3.4% patients), 800mg/day (61% patients), 1200mg/day (27.1% patients) or 1600mg/day (8.5% patients). At 3months, 82.0% (n=72) of patients achieved a ≥50% reduction in seizure frequency, compared to 79.7% (n=67) of patients at 6months and 83.0% (n=49) at 12months. Patients who suffered secondary generalized tonic-clonic (SGTC) seizures had seizure-free rates of 71% (n=27), 69.6% (n=29), and 72.7% (n=16) at 3, 6, and 12months, respectively. Overall, 18 patients (15.3%) reported AEs of instability and dizziness (n=9), somnolence (n=3), mild hyponatremia (n=3), headache (n=1), hypertriglyceridemia (n=1), and allergic reaction (n=1), which caused ESL discontinuation of ESL treatment. ESL is effective and well tolerated as monotherapy for patients with POS, which supports previous findings. Early use is supported by its frequent use as monotherapy in this study and lack of severe side effects. Copyright © 2017 Elsevier Inc. All rights reserved.

Electrostatic Levitator (ESL)

NASA Technical Reports Server (NTRS)

1998-01-01

Dr. Rulison of Space System LORAl working with the Electrostatic Levitation (ESL) prior to the donation. Space System/LORAL donated the electrostatic containerless processing system to NASA's Marshall Space Flight Center (MSFC). The official hand over took place in July 1998.

Cybernetics: A Model for Feedback in the ESL Classroom.

ERIC Educational Resources Information Center

Zamel, Vivian

1981-01-01

Examines cybernetics as a model which provides framework with which to view communicators and the communications in the ESL classroom because it implies the kind of feedback the learner can assimilate and act upon. (Author/BK)

Optimizing an immersion ESL curriculum using analytic hierarchy process.

PubMed

Tang, Hui-Wen Vivian

2011-11-01

The main purpose of this study is to fill a substantial knowledge gap regarding reaching a uniform group decision in English curriculum design and planning. A comprehensive content-based course criterion model extracted from existing literature and expert opinions was developed. Analytical hierarchy process (AHP) was used to identify the relative importance of course criteria for the purpose of tailoring an optimal one-week immersion English as a second language (ESL) curriculum for elementary school students in a suburban county of Taiwan. The hierarchy model and AHP analysis utilized in the present study will be useful for resolving several important multi-criteria decision-making issues in planning and evaluating ESL programs. This study also offers valuable insights and provides a basis for further research in customizing ESL curriculum models for different student populations with distinct learning needs, goals, and socioeconomic backgrounds. Copyright © 2011 Elsevier Ltd. All rights reserved.

Around Marshall

NASA Image and Video Library

2003-01-01

This Photo, which appeared on the July cover of `Physics Today', is of the Electrostatic Levitator (ESL) at NASA's Marshall Space Flight Center (MSFC). The ESL uses static electricity to suspend an object (about 3-4 mm in diameter) inside a vacuum chamber allowing scientists to record a wide range of physical properties without the sample contracting the container or any instruments, conditions that would alter the readings. Once inside the chamber, a laser heats the sample until it melts. The laser is then turned off and the sample cools, changing from a liquid drop to a solid sphere. In this particular shot, the ESL contains a solid metal sample of titanium-zirconium-nickel alloy. Since 1977, the ESL has been used at MSFC to study the characteristics of new metals, ceramics, and glass compounds. Materials created as a result of these tests include new optical materials, special metallic glasses, and spacecraft components.

Back-channel-etch amorphous indium-gallium-zinc oxide thin-film transistors: The impact of source/drain metal etch and final passivation

NASA Astrophysics Data System (ADS)

Nag, Manoj; Bhoolokam, Ajay; Steudel, Soeren; Chasin, Adrian; Myny, Kris; Maas, Joris; Groeseneken, Guido; Heremans, Paul

2014-11-01

We report on the impact of source/drain (S/D) metal (molybdenum) etch and the final passivation (SiO2) layer on the bias-stress stability of back-channel-etch (BCE) configuration based amorphous indium-gallium-zinc oxide (a-IGZO) thin-film transistors (TFTs). It is observed that the BCE configurations TFTs suffer poor bias-stability in comparison to etch-stop-layer (ESL) TFTs. By analysis with transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS), as well as by a comparative analysis of contacts formed by other metals, we infer that this poor bias-stability for BCE transistors having Mo S/D contacts is associated with contamination of the back channel interface, which occurs by Mo-containing deposits on the back channel during the final plasma process of the physical vapor deposited SiO2 passivation.

More than a "Basic Skill": Breaking down the Complexities of Summarizing for ABE/ESL Learners

ERIC Educational Resources Information Center

Ouellette-Schramm, Jennifer

2015-01-01

This article describes the complex cognitive and linguistic challenges of summarizing expository text at vocabulary, syntactic, and rhetorical levels. It then outlines activities to help ABE/ESL learners develop corresponding skills.

Intersegmental Articulation.

ERIC Educational Resources Information Center

CATESOL Journal, 1996

1996-01-01

This English-as-a-Second Language (ESL) journal periodically devotes entire issues to specific themes. The theme of this issue is "Intersegmental Articulation" (especially in California schools). Articles include: "Why Is ESL a Burning Issue?" (Robby Ching, Anne Ediger, Debbie Poole); "Challenges Facing California ESL…

ESL Magazine, 2000.

ERIC Educational Resources Information Center

Rosenthal, Marilyn, Ed.

2000-01-01

Issues in this volume include the following feature articles: "Grammar: Rules and Reasons Working Together" (Diane Larsen-Freeman); "TESOL Sets Sail for Vancouver" (Nancy Storer); "The Reading Lab: An Invitation to Read" (Jean Zukowski/Faust); "Quebec: A Unique North American ESL Teaching Experience"…

The effect of visuals on non-native English students' learning of the basic principles and laws of motion

NASA Astrophysics Data System (ADS)

Yang, Quan

2001-10-01

This study, involving 154 undergraduate college students in China, was conducted to determine whether the surface structure of visual graphics affect content learning when the learner was a non-native English speaker and learning took place in a non-English speaking environment. Instruction with concrete animated graphics resulted in significantly higher achievement, when compared to instruction with concrete static, abstract static, abstract animated graphics or text only without any graphical illustrations. It was also found, unexpectedly, the text-only instruction resulted in the second best achievement, significantly higher than instruction with concrete static, abstract static, and abstract animated graphics. In addition, there was a significant interaction with treatment and test item, which indicated that treatment effects on graphic-specific items differed from those on definitional items. Additional findings indicated that relation to graphics directly or indirectly from the text that students studied had little impact on their performance in the posttests. Further, 51% of the participants indicated that they relied on some graphical images to answer the test questions and 19% relied heavily on graphics when completing the tests. In conclusion, concrete graphics when combined with animation played a significant role in enhancing ESL student performance and enabled the students to achieve the best learning outcomes as compared to abstract animated, concrete static, and abstract static graphics. This result suggested a significant innovation in the design and development of ESL curriculum in computer-based instruction, which would enable ESL students to perform better and achieve the expected outcomes in content area learning.

28 CFR 544.42 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION... designee shall assign to an education staff member the responsibility to coordinate the institution's ESL... ESL Program Record, and shall place it in the inmate's education file. (d) Ordinarily, there will be...

Advanced software development workstation. Engineering scripting language graphical editor: DRAFT design document

NASA Technical Reports Server (NTRS)

1991-01-01

The Engineering Scripting Language (ESL) is a language designed to allow nonprogramming users to write Higher Order Language (HOL) programs by drawing directed graphs to represent the program and having the system generate the corresponding program in HOL. The ESL system supports user generation of HOL programs through the manipulation of directed graphs. The components of this graphs (nodes, ports, and connectors) are objects each of which has its own properties and property values. The purpose of the ESL graphical editor is to allow the user to create or edit graph objects which represent programs.

ESL-speaking immigrant women's disillusions: voices of health care in Canada: an ethnodrama.

PubMed

Nimmon, Laura E

2007-04-01

This article describes a research project that investigated whether language barriers play a part in immigrant women's health decreasing when they move to Canada. The findings are then represented in the form of an ethnodrama entitled "ESL-Speaking Immigrant Women's Disillusions: Voices of Health Care in Canada." I suggest that the play is catalytic because it encourages target audiences to empathize with the silenced voices of ESL-speaking immigrant women who live in Canada. I then conclude with a reflection about the potential that the genre of ethnodrama has for social change through its reflexive and critical nature.

ESL Participation as a Mechanism for Advancing Health Literacy in Immigrant Communities

PubMed Central

SANTOS, MARICEL G.; HANDLEY, MARGARET A.; OMARK, KARIN; SCHILLINGER, DEAN

2014-01-01

A reliance on the conceptualization of health literacy as functional skill has limited our views of the adult English-as-a-Second-Language (ESL) context as a site for health literacy interventions. To explore the contributions of alternative views of literacy as social practice to health literacy research, we examined teacher survey data and learner outcomes data collected as part of a multi-year collaboration involving The California Diabetes Program (CDP), university researchers, and adult ESL teachers. The survey results (n=144 teachers) indicated that ESL teachers frequently model effective pedagogical practices that mediate social interaction around health content, the basis for acquiring new literacy skills and practices. In the classroom pilot, (n=116 learners), the majority of learners reported they had learned about diabetes risk factors and prevention strategies, which affirmed existing healthy behaviors or prompted revision of unhealthy ones. About two-thirds of the learners reported sharing preventive health content with members of out-of-school social networks. This study represents a first-step in research efforts to account more fully for the mechanisms by which social interaction and social support facilitate health literacy outcomes in ESL contexts, which should complement what we already know about the development of health literacy as functional skill. PMID:25315586

Soy-Leaf Extract Exerts Atheroprotective Effects via Modulation of Krüppel-Like Factor 2 and Adhesion Molecules

PubMed Central

Han, Jong-Min; Li, Hua; Cho, Moon-Hee; Baek, Seung-Hwa; Lee, Chul-Ho; Park, Ho-Yong; Jeong, Tae-Sook

2017-01-01

Soy-leaf extracts exert their cardioprotective effects by inducing endothelium-dependent vasodilation in the arteries, and they favorably modulate the serum lipid profile. In this study, we investigated the atheroprotective effects of an ethanol extract of soy leaf (ESL) in human umbilical vein endothelial cells (HUVECs) and high-cholesterol diet (HCD)-fed low-density lipoprotein receptor deficient (LDLR−/−) mice. ESL induced the expression of Krüppel-like factor 2 (KLF2), an endothelial transcription factor, and endothelial nitric oxide synthase (eNOS), and suppressed the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) through moderate inflammatory signal activation, not only in tumor necrosis factor-α (TNF-α)-stimulated HUVECs but also in 7-ketocholesterol (7-KC)-stimulated HUVECs. ESL supplementation reduced aortic lesion formation in Western diet-fed LDLR−/− mice by 46% (p < 0.01) compared to the HCD group. ESL also markedly decreased the aortic expression levels of VCAM-1, ICAM-1, monocyte chemotactic protein-1 (MCP-1), TNF-α, IL-6, IL-1β, matrix metallopeptidase 9 (MMP-9), and fractalkine, while the expression of KLF2 was significantly increased. These results suggest that ESL supplementation has potential for preventing HCD-induced atherosclerosis effectively. PMID:28208647

Improving clinical communication of students with English as a second language (ESL) using online technology: a small scale evaluation study.

PubMed

Rogan, Fran; San Miguel, Caroline

2013-09-01

Increasingly, students with English as a second language (ESL) are enrolled in nursing degrees in English speaking countries (Wang et al., 2008). However, they may be at risk of clinical practice failure due to communication difficulties associated with unfamiliar linguistic and cultural factors (Guhde, 2003). This paper describes and evaluates an innovation to assist ESL nursing students at an Australian university develop their clinical communication skills and practice readiness by providing online learning resources, using podcast and vodcast technology, that blend with classroom activities and facilitate flexible and independent learning. The innovation builds on an intensive clinical language workshop program called 'Clinically Speaking' which has evolved through a cyclical process of ongoing research to produce resources in response to students' learning needs. Whilst uptake of the resources was modest, students of ESL as well as English speaking backgrounds (ESB) found the resources improved their clinical preparation and confidence by increasing their understanding of expectations, clinical language and communication skills. The innovation, developed with a modest budget, shows potential in developing ESL and ESB students' readiness for clinical communication, enabling them to engage in clinical practice to develop competency standards required of nursing graduates and registration authorities. Copyright © 2012 Elsevier Ltd. All rights reserved.

ESL participation as a mechanism for advancing health literacy in immigrant communities.

PubMed

Santos, Maricel G; Handley, Margaret A; Omark, Karin; Schillinger, Dean

2014-01-01

A reliance on the conceptualization of health literacy as functional skill has limited researchers' views of the adult English-as-a-second-language (ESL) context as a site for health literacy interventions. To explore the contributions of alternative views of literacy as social practice to health literacy research, the authors examined teacher survey data and learner outcomes data collected as part of a multiyear collaboration involving the California Diabetes Program, university researchers, and adult ESL teachers. The survey results (n=144 teachers) indicated that ESL teachers frequently model effective pedagogical practices that mediate social interaction around health content, the basis for acquiring new literacy skills and practices. In the classroom pilot (n=116 learners), the majority of learners reported they had learned about diabetes risk factors and prevention strategies, which affirmed existing healthy behaviors or prompted revision of unhealthy ones. About two thirds of the learners reported sharing preventive health content with members of out-of-school social networks. This study represents a first step in research efforts to account more fully for the mechanisms by which social interaction and social support facilitate health literacy outcomes in ESL contexts, which should complement what is already known about the development of health literacy as functional skill.

Healthy eating for life: rationale and development of an English as a second language (ESL) curriculum for promoting healthy nutrition.

PubMed

Martinez, Josefa L; Rivers, Susan E; Duncan, Lindsay R; Bertoli, Michelle; Domingo, Samantha; Latimer-Cheung, Amy E; Salovey, Peter

2013-12-01

Low health literacy contributes significantly to cancer health disparities disadvantaging minorities and the medically underserved. Immigrants to the United States constitute a particularly vulnerable subgroup of the medically underserved, and because many are non-native English speakers, they are pre-disposed to encounter language and literacy barriers across the cancer continuum. Healthy Eating for Life (HE4L) is an English as a second language (ESL) curriculum designed to teach English language and health literacy while promoting fruit and vegetable consumption for cancer prevention. This article describes the rationale, design, and content of HE4L. HE4L is a content-based adult ESL curriculum grounded in the health action process approach to behavior change. The curriculum package includes a soap opera-like storyline, an interactive student workbook, a teacher's manual, and audio files. HE4L is the first teacher-administered, multimedia nutrition-education curriculum designed to reduce cancer risk among beginning-level ESL students. HE4L is unique because it combines adult ESL principles, health education content, and behavioral theory. HE4L provides a case study of how evidence-based, health promotion practices can be implemented into real-life settings and serves as a timely, useful, and accessible nutrition-education resource for health educators.

ESL Magazine, 2001.

ERIC Educational Resources Information Center

Beall, Kathleen R., Ed.

2001-01-01

The six issues in this volume include the following articles: "Preview of TESOL 2001" (Adelaide Heyde Parsons); "Six Internet Pioneers Teach English to the World" (Dennis Oliver, Randall Davis, Elaine Hoter, Charles Kelly, Dave Sperling, and Ruth Vilmi); "Integrated Skills in the ESL/EFL Classroom" (Rebecca Oxford);…

Advanced software development workstation: Knowledge base methodology: Methodology for first Engineering Script Language (ESL) knowledge base

NASA Technical Reports Server (NTRS)

Peeris, Kumar; Izygon, Michel

1993-01-01

This report explains some of the concepts of the ESL prototype and summarizes some of the lessons learned in using the prototype for implementing the Flight Mechanics Tool Kit (FMToolKit) series of Ada programs.

Assessing the Math Performance of Young ESL Students.

ERIC Educational Resources Information Center

Lee, Fong Yun; Silverman, Fredrick L.; Montoya, Patricia

2002-01-01

Describes proven assessment strategies, which, used separately or in combination, can help young ESL students express their understanding of math concepts while building their English-language skills: Manipulative objects, diagrams, and physical movement. Also describes other assessment techniques including self-assessment, interviewing, and…

Rational Deletion Cloze Processing Strategies: ESL and Native English.

ERIC Educational Resources Information Center

Markham, Paul L.

1987-01-01

Explores cloze sensitivity to global comprehension by means of retrospective interview techniques. No significant differences were found between English as a second language (ESL) college students (N=14) and native English-speaking students (N=14) in their processing strategies. (Author/CB)

The Validity of Likeability as a New Construct of ESL Pronunciation

ERIC Educational Resources Information Center

Alotaibi, Hmoud

2014-01-01

The most significant constructs of ESL pronunciation models are "accentedness," "intelligibility," and "comprehensibility" (Derwing & Munro 2005; Jenkins, 2000; Pickering, 2006). It is clear though that the assessment of these characteristics shows no consideration for the potential affection of the assessor…

Overnight switching from oxcarbazepine to eslicarbazepine acetate: an observational study.

PubMed

Schmid, E; Kuchukhidze, G; Kirschner, M; Leitinger, M; Höfler, J; Rohracher, A; Kalss, G; Wendling, A-S; Steinhoff, B J; Trinka, E

2017-04-01

There are clinical situations where it might be appropriate to switch patients from immediate-release oxcarbazepine (OXC) to eslicarbazepine acetate (ESL). We investigated the effects of transitioning patients overnight from OXC to ESL. A retrospective, single-center study was conducted in which patients with drug-resistant focal epilepsy on a stable dose of immediate-release OXC for at least 4 weeks were switched overnight to ESL. Patients were switched because they experienced persistent seizures with OXC but were unable to tolerate increased OXC dosing due to adverse events. Tolerability was assessed using the Adverse Events Profile (AEP), quality of life was assessed using the Quality of Life in Epilepsy Inventory 10 (QOLIE-10), and alertness was assessed as reaction time using a subtest of the Test Battery for Attention Performance version 2.3. Assessments were performed immediately prior to and 5 days after switching from OXC to ESL (days 0 and 5, respectively). The analysis included 21 patients (12 women, 9 men; mean age 36 years). After switching from OXC to ESL, there were significant improvements in mean scores for AEP (P<.001), QOLIE-10 (P=.001), and alertness (P<.05). Adverse Events Profile total scores improved for 21/21 (100.0%) patients, QOLIE-10 total scores improved for 17/21 (81.0%) patients, and alertness scores improved for 16/21 (76.2%) patients. In this short-term, single-center study, an overnight switch from twice-daily OXC to once-daily ESL in patients with drug-resistant focal epilepsies resulted in improvements in side effects, quality of life, and alertness. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Parent-child reading interactions among English and English as a second language speakers in an underserved pediatric clinic in Hawai'i.

PubMed

Kitabayashi, Kristyn M; Huang, Gary Y; Linskey, Katy R; Pirga, Jason; Bane-Terakubo, Teresa; Lee, Meta T

2008-10-01

The purpose of this study was to compare reading patterns between English-speaking and English as a Second Language (ESL) families in a health care setting in Hawai'i. A cross-sectional study was performed at an underserved pediatric primary care clinic in Hawai'i. Caregivers of patients between the ages of 6 months to 5 years were asked questions regarding demographics and parent-child reading interactions. Respondents were categorized into English-speaking or ESL groups based on primary language spoken at home. Pearson chi2 tests and Fisher exact tests were performed to compare demographic differences, reading frequency, and reading attitudes between groups. One-hundred three respondents completed the survey Fifty percent were ESL. All ESL respondents were of Asian-Pacific Islander (API) or mixed Asian ethnicity. All Caucasians in the study (n = 9) were in the English-speaking group. Between the English-speaking (n = 52) and ESL (n = 51) groups, there were no significant statistical differences in age or gender of the child, reading attitudes, or parent's educational status. Parents in the ESL group read to their children significantly fewer days per week than their English-speaking counterparts, had significantly fewer books in the home, and lived significantly fewer years in the United States. The findings suggest that API immigrant families share similar attitudes about reading as English-speaking families in Hawai'i but have significantly fewer books in their household and read significantly less frequently Physicians working with API populations should be aware that immigrant children may have fewer reading interactions and should counsel parents on the importance of reading daily.

Ultra-High Temperature Materials Characterization for Propulsion Applications

NASA Technical Reports Server (NTRS)

Rogers, Jan; Hyers, Robert

2007-01-01

Propulsion system efficiency increases as operating temperatures are increased. Some very high-temperature materials are being developed, including refractory metal alloys, carbides, borides, and silicides. System design requires data for materials properties at operating temperatures. Materials property data are not available for many materials of interest at the desired operating temperatures (up to approx. 3000 K). The objective of this work is to provide important physical property data at ultra-high temperatures. The MSFC Electrostatic levitation (ESL) facility can provide measurements of thermophysical properties which include: creep strength, density and thermal expansion for materials being developed for propulsion applications. The ESL facility uses electrostatic fields to position samples between electrodes during processing and characterization studies. Because the samples float between the electrodes during studies, they are free from any contact with a container or test apparatus. This provides a high purity environment for the study of high-temperature, reactive materials. ESL can be used to process a wide variety of materials including metals, alloys, ceramics, glasses and semiconductors. The MSFC ESL has provided non-contact measurements of properties of materials up to 3400 C. Density and thermal expansion are measured by analyzing digital images of the sample at different temperatures. Our novel, non-contact method for measuring creep uses rapid rotation to deform the sample. Digital images of the deformed samples are analyzed to obtain the creep properties, which match those obtained using ASTM Standard E-139 for Nb at 1985 C. Data from selected ESL-based characterization studies will be presented. The ESL technique could support numerous propulsion technologies by advancing the knowledge base and the technology readiness level for ultra-high temperature materials. Applications include non-eroding nozzle materials and lightweight, high-temperature alloys for turbines and structures.

Three Empowering Curricular Innovations for Service-Learning in ESL Programs

ERIC Educational Resources Information Center

Perren, James; Grove, Nuray; Thornton, Julie

2013-01-01

This article describes three service-learning projects implemented in three different ESL programs in the United States. Each description includes typical course goals, service-learning assignments, reflection activities, student learning outcomes, and pedagogical challenges. The first project was developing digital literacy through…

2014 Service Academy Gender Relations Survey: Statistical Methodology Report

DTIC Science & Technology

2014-12-12

PERFORMING ORGANIZATION NAME(S) AND ADDRESS( ESl 8 . PERFORMING ORGANIZATION Defense Manpower Data Center REPORT NUMBER Defense Research, Surveys, and...AGENCY NAME($) AND ADDRESS( ESl 10 . SPONSOR/MONITOR’S ACRONYM(S) Sexual Assault Prevention and Response Office (SAPRO) 4800 Mark Center Drive, Suite

Material Writer's Guide.

ERIC Educational Resources Information Center

Byrd, Patricia, Ed.

This guide is a collection of essays on the writing of English-as-a-Second-Language (ESL) textbooks and other instructional materials. Articles include: "Writing and Publishing Textbooks (Patricia Byrd); "The Craft of Materials Writing" (Fraida Dubin); "Considering Culture: Guidelines for ESL/EFL Textbook Writers" (Gayle Nelson); "Issues in the…

An Annotated Bibliography of Research on Reading and Adults Learning English as a Second Language.

ERIC Educational Resources Information Center

Burt, Miriam, Comp.; Florez, MaryAnn, Comp.; Terrill, Lynda, Comp.; Van Duzer, Carol, Comp.

This annotated bibliography contains 27 references regarding research on reading and adults learning English as a Second Language (ESL). None of the resources are more than 10 years old. (Adjunct ERIC Clearinghouse for ESL Literacy Education) (KFT)

The effects of linguistic modification on ESL students' comprehension of nursing course test items.

PubMed

Bosher, Susan; Bowles, Melissa

2008-01-01

Recent research has indicated that language may be a source of construct-irrelevant variance for non-native speakers of English, or English as a second language (ESL) students, when they take exams. As a result, exams may not accurately measure knowledge of nursing content. One accommodation often used to level the playing field for ESL students is linguistic modification, a process by which the reading load of test items is reduced while the content and integrity of the item are maintained. Research on the effects of linguistic modification has been conducted on examinees in the K-12 population, but is just beginning in other areas. This study describes the collaborative process by which items from a pathophysiology exam were linguistically modified and subsequently evaluated for comprehensibility by ESL students. Findings indicate that in a majority of cases, modification improved examinees' comprehension of test items. Implications for test item writing and future research are discussed.

Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability.

PubMed

Leiva, Magdalena; Quintana, Juan A; Ligos, José M; Hidalgo, Andrés

2016-01-08

The life-long maintenance of haematopoietic stem and progenitor cells (HSPCs) critically relies on environmental signals produced by cells that constitute the haematopoietic niche. Here we report a cell-intrinsic mechanism whereby haematopoietic cells limit proliferation within the bone marrow, and show that this pathway is repressed by E-selectin ligand 1 (ESL-1). Mice deficient in ESL-1 display aberrant HSPC quiescence, expansion of the immature pool and reduction in niche size. Remarkably, the traits were transplantable and dominant when mutant and wild-type precursors coexisted in the same environment, but were independent of E-selectin, the vascular receptor for ESL-1. Instead, quiescence is generated by unrestrained production of the cytokine TGFβ by mutant HSPC, and in vivo or in vitro blockade of the cytokine completely restores the homeostatic properties of the haematopoietic niche. These findings reveal that haematopoietic cells, including the more primitive compartment, can actively shape their own environment.

Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability

PubMed Central

Leiva, Magdalena; Quintana, Juan A.; Ligos, José M.; Hidalgo, Andrés

2016-01-01

The life-long maintenance of haematopoietic stem and progenitor cells (HSPCs) critically relies on environmental signals produced by cells that constitute the haematopoietic niche. Here we report a cell-intrinsic mechanism whereby haematopoietic cells limit proliferation within the bone marrow, and show that this pathway is repressed by E-selectin ligand 1 (ESL-1). Mice deficient in ESL-1 display aberrant HSPC quiescence, expansion of the immature pool and reduction in niche size. Remarkably, the traits were transplantable and dominant when mutant and wild-type precursors coexisted in the same environment, but were independent of E-selectin, the vascular receptor for ESL-1. Instead, quiescence is generated by unrestrained production of the cytokine TGFβ by mutant HSPC, and in vivo or in vitro blockade of the cytokine completely restores the homeostatic properties of the haematopoietic niche. These findings reveal that haematopoietic cells, including the more primitive compartment, can actively shape their own environment. PMID:26742601

EFL/ESL Textbook Selection in Korea and East Asia - Relevant Issues and Literature Review

NASA Astrophysics Data System (ADS)

Meurant, Robert C.

EFL/ESL departments periodically face the problem of textbook selection. Cogent issues are that non-native speakers will use L2 English mainly to communicate with other non-native English speakers, so an American accent is becoming less important. L2 English will mainly be used in computer-mediated communication, hence the importance of L2 Digital Literacy. The convergence of Information Communication Technologies is radically impacting Second Language Acquisition, which is integrating web-hosted Assessment and Learning Management Systems. EFL/ESL textbooks need to be compatible with blended learning, prepare students for a globalized world, and foster autonomous learning. I summarize five papers on EFL/ESL textbook evaluation and selection, and include relevant material for adaptation. Textbooks are major sources of contact with the target language, so selection is an important decision. Educators need to be systematic and objective in their approach, adopting a selection process that is open, transparent, accountable, participatory, informed and rigorous.

Neurological adverse events of new generation sodium blocker antiepileptic drugs. Meta-analysis of randomized, double-blinded studies with eslicarbazepine acetate, lacosamide and oxcarbazepine.

PubMed

Zaccara, Gaetano; Giovannelli, Fabio; Maratea, Dario; Fadda, Valeria; Verrotti, Alberto

2013-09-01

Analysis of overall tolerability and neurological adverse effects (AEs) of eslicarbazepine acetate (ESL), lacosamide (LCM) and oxcarbazepine (OXC) from double-blind, placebo-controlled trials. Indirect comparisons of patients withdrawing because of AEs, and the incidence of some vestibulocerebellar AEs between these three antiepileptic dugs (AEDs). We searched MEDLINE for all randomized, double-blind, placebo-controlled trials investigating therapeutic effects of fixed oral doses of ESL, LCM and OXC in patients with drug resistant epilepsy. Withdrawal rate due to AEs, percentages of patients with serious AEs, and the proportion of patients experiencing any neurological AE, nausea and vomiting were assessed for their association with the experimental drug. Analyses were performed between recommended daily doses of each AED according to the approved summary of product characteristics (SPC). Risk differences were used to evaluate the association of any AE [99% confidence intervals (CIs)] or study withdrawals because of AEs (95% CIs) with the experimental drug. Indirect comparisons between withdrawal rate and AEs dizziness, coordination abnormal/ataxia and diplopia were estimated according to network meta-analysis (Net-MA). Eight randomized, placebo-controlled, double-blind trials (4 with ESL, 3 with LCM, and 1 with OXC) were included in our analysis. At high doses (OXC 1200mg, ESL 1200mg and LCM 400mg) there was an increased risk of AE-related study withdrawals compared to placebo for all drugs. Several AEs were associated with the experimental drug. Both number and frequency of AEs were dose-related. At high recommended doses, patients treated with OXC withdrew from the experimental treatment significantly more frequently than patients treated with ESL and LCM. Furthermore, the AEs coordination abnormal/ataxia and diplopia were significantly more frequently observed in patients treated with OXC compared to patients treated with LCM and ESL. The overall tolerability of AEDs and the incidence of several neurological AEs were clearly dose-dependent. Indirect comparisons between these AEDs, taking into account dose-effect, showed that OXC may be associated with more frequent neurological AEs than LCM and ESL. Copyright © 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Better Acquisition Management through Alternative Dispute Resolution (ADR) and Other Best Practices for Preventing and Resolving Bid Protests

DTIC Science & Technology

2012-01-24

ESLS ) made cost = = ^Åèìáëáíáçå=oÉëÉ~êÅÜ=mêçÖê~ã= do^ar^qb=p`elli=lc=_rpfkbpp=C=mr_if`=mlif`v - 66 - k^s^i=mlpqdo^ar^qb=p`elli= and availability...Mobility Command (AMC). Regarding cost, the ESLS found that the KC-135 fleet would incur “significant cost increases” between 2001 and 2040, but “no...the ESLS publication, the Air Force planned to wait until 2013 to begin KC-135 replacement. (Gupta, Belasco, Else, & O’Rourke, 2003, pp. 2– 3

Microgravity

NASA Image and Video Library

1998-09-30

The Electrostatic Levitator (ESL) Facility established at Marshall Space Flight Center (MSFC) supports NASA's Microgravity Materials Science Research Program. NASA materials science investigations include ground-based, flight definition and flight projects. Flight definition projects, with demanding science concept review schedules, receive highest priority for scheduling experiment time in the Electrostatic Levitator (ESL) Facility.

Tutoring ESL: A Handbook for Volunteers.

ERIC Educational Resources Information Center

Tacoma Community House, WA.

This handbook contains several different sections to aid volunteers teaching English-as-a-Second-Language (ESL) to refugees. Part 1, "Getting Started," discusses cultural differences and difficulties the students may encounter. Part 2, "Mechanics of Teaching," offers tips on teaching refugees and general teaching methods. Lesson planning,…

Unexpected Poor Comprehenders among Adolescent ESL Students

ERIC Educational Resources Information Center

Li, Miao; Kirby, John R.

2014-01-01

This study explored characteristics of reading comprehension difficulties among Chinese students learning English as a second language (ESL). Two hundred forty-six Grade 8 English-immersion students in China were administered a battery of reading-related and reading comprehension tests. Three groups of comprehenders matched on age, nonverbal…

Are Schools Getting Tongue-Tied? ESL Programs Face New Challenges

ERIC Educational Resources Information Center

Schachter, Ron

2013-01-01

Spanish-speaking students, but the ESL map is undergoing a dramatic transformation that is challenging K12 schools to cope with a burgeoning number of different native languages--more than 100 in some locations--as new immigrants arrive in districts across the country. The number…

Topical Knowledge and ESL Writing

ERIC Educational Resources Information Center

He, Ling; Shi, Ling

2012-01-01

This study investigates the effects of topical knowledge on ESL (English as a Second Language) writing performance in the English Language Proficiency Index (LPI), a standardized English proficiency test used by many post-secondary institutions in western Canada. The participants were 50 students with different levels of English proficiency…

Training Adult ESL Learners in Metacognitive Reading Strategies

ERIC Educational Resources Information Center

Huang, Jiuhan; Nisbet, Deanna

2012-01-01

This article is written as a practical guide to aid teachers in metacognitive reading strategy instruction. The nature of metacognitive strategies is explored, followed by specific procedures for implementing effective metacognitive strategy instruction in the adult ESL classroom. Chamot and O'Malley's (1994) five-phase strategy instruction…

Bilingual/ESL Programs Evaluation Report, 1999-2000.

ERIC Educational Resources Information Center

Gonzalez, Rosa Maria

The Austin Independent School District (AISD) provides bilingual education and English-as-a-Second-Language (ESL) programs for limited-English-proficient (LEP) students. Mandatory evaluation of these programs involved the following: data from the Student Master File (information on each student's grade level, ethnicity, and socioeconomic status);…

Impromptu Speech Gamification for ESL/EFL Students

ERIC Educational Resources Information Center

Girardelli, Davide

2017-01-01

Courses: Any introductory undergraduate public-speaking course, in particular in ESL/EFL contexts. Objectives: This single-class activity is intended to (1) build students' ability to communicate orally "off the cuff;" (2) foster students' understanding of the major organizational formats used in organizing speeches; and (3) increase…

Malaysian Instructors' Assessment Beliefs in Tertiary ESL Classrooms

ERIC Educational Resources Information Center

Elshawa, Niveen R. M.; Abdullah, Ain Nadzimah; Rashid, Sabariah Md

2017-01-01

Language assessment can be a valuable tool for providing information regarding language teaching. Given the importance of assessment that has undergone much change, there are important issues that warrant investigation, particularly those related to language instructors. Understanding the assessment beliefs of ESL instructors, especially at the…

Ideas for Teaching Job-Search Based ESL.

ERIC Educational Resources Information Center

Lotman, Marianne

1993-01-01

Focuses on the employment-related aspect of English-as-a-Second-Language (ESL) classes at the intermediate and advanced levels. Activities described include researched pair presentations, company research, working through occupational modules and an exercise to enhance self-image. Networking with colleagues and the community helps in the…

Standards for ESL/EFL Teachers of Adults

ERIC Educational Resources Information Center

TESOL Press, 2013

2013-01-01

"Standards for ESL/EFL Teachers of Adult Learners" offers performance indicators, vignettes, and evaluation tools for instructors. These clearly organized components will help instructors identify the qualities and practices to pursue in their teaching. The standards in this book address planning, instructing, and assessing as the basis…

Using Accelerated Reader with ESL Students.

ERIC Educational Resources Information Center

Hamilton, Betty

1997-01-01

Describes the use of Accelerated Reader, a computer program that instantly provides scored tests on a variety of books read by high school ESL (English as a Second Language) students as free voluntary reading. Topics include reading improvement programs, including writing assignments; and changes in students' reading habits. (LRW)

Issues and Developments in English and Applied Linguistics (IDEAL), 1994.

ERIC Educational Resources Information Center

Dickerson, Wayne B., Ed.; Kachru, Yamuna, Ed.

1994-01-01

Seven papers on topics of English-as-a-Second-Language (ESL) instruction, language research, and applied linguistics are presented: "ESL Students and Common L2 Conversation-Making Expressions" (Eli Hinkel); "Thematic Options in Reporting Previous Research" (Sarah Thomas, Thomas Hawes); "Connected Speech Modifications in…

Text-Frame Relationships and ESL.

ERIC Educational Resources Information Center

Burquest, Donald A.; Henry, Floreen Barger

The relationship of contextual background to comprehension of written texts is discussed with reference to instruction in English as a second language (ESL). A theory advanced by Kerry Stewart Robichaux proposes six possible relationships between a text and its cultural "frame." Applications of the six text-frame relationships to foreign…

Integrating health literacy and ESL: an interdisciplinary curriculum for Hispanic immigrants.

PubMed

Soto Mas, Francisco; Mein, Erika; Fuentes, Brenda; Thatcher, Barry; Balcázar, Héctor

2013-03-01

Adult Hispanic immigrants are at a greater risk of experiencing the negative outcomes related to low health literacy, as they confront cultural and language barriers to the complex and predominately monolingual English-based U.S. health system. One approach that has the potential for simultaneously addressing the health, literacy, and language needs of Hispanics is the combination of health literacy and English as a second language (ESL) instruction. The purpose of the project was to evaluate the feasibility of using ESL instruction as a medium for improving health literacy among Hispanic immigrants. Objectives included the development, implementation, and evaluation of an interdisciplinary health literacy/ESL curriculum that integrates theories of health literacy and health behavior research and practice, sociocultural theories of literacy and communication, and adult learning principles. This article describes the curriculum development process and provides preliminary qualitative data on learners' experiences with the curriculum. Results indicate that the curriculum was attractive to participants and that they were highly satisfied with both the format and content. The curriculum described here represents one example of an audience-centered approach designed to meet the specific health and literacy needs of the Hispanic population on the U.S.-Mexico border. The combination of ESL and health literacy contributed to a perceived positive learning experience among participants. Interdisciplinary approaches to health literacy are recommended.

Evidence for multidecadal variability in US extreme sea level records

NASA Astrophysics Data System (ADS)

Wahl, Thomas; Chambers, Don P.

2015-03-01

We analyze a set of 20 tide gauge records covering the contiguous United States (US) coastline and the period from 1929 to 2013 to identify long-term trends and multidecadal variations in extreme sea levels (ESLs) relative to changes in mean sea level (MSL). Different data sampling and analysis techniques are applied to test the robustness of the results against the selected methodology. Significant but small long-term trends in ESLs above/below MSL are found at individual sites along most coastline stretches, but are mostly confined to the southeast coast and the winter season when storm surges are primarily driven by extratropical cyclones. We identify six regions with broadly coherent and considerable multidecadal ESL variations unrelated to MSL changes. Using a quasi-nonstationary extreme value analysis, we show that the latter would have caused variations in design relevant return water levels (50-200 year return periods) ranging from ˜10 cm to as much as 110 cm across the six regions. The results raise questions as to the applicability of the "MSL offset method," assuming that ESL changes are primarily driven by changes in MSL without allowing for distinct long-term trends or low-frequency variations. Identifying the coherent multidecadal ESL variability is crucial in order to understand the physical driving factors. Ultimately, this information must be included into coastal design and adaptation processes.

Integrating Health Literacy and ESL: An Interdisciplinary Curriculum for Hispanic Immigrants

PubMed Central

Mas, Francisco Soto; Mein, Erika; Fuentes, Brenda; Thatcher, Barry; Balcázar, Héctor

2013-01-01

Adult Hispanic immigrants are at a greater risk of experiencing the negative outcomes related to low health literacy, as they confront cultural and language barriers to the complex and predominately monolingual English-based U.S. health system. One approach that has the potential for simultaneously addressing the health, literacy, and language needs of Hispanics is the combination of health literacy and English as a second language (ESL) instruction. The purpose of the project was to evaluate the feasibility of using ESL instruction as a medium for improving health literacy among Hispanic immigrants. Objectives included the development, implementation, and evaluation of an interdisciplinary health literacy/ESL curriculum that integrates theories of health literacy and health behavior research and practice, sociocultural theories of literacy and communication, and adult learning principles. This article describes the curriculum development process and provides preliminary qualitative data on learners’ experiences with the curriculum. Results indicate that the curriculum was attractive to participants and that they were highly satisfied with both the format and content. The curriculum described here represents one example of an audience-centered approach designed to meet the specific health and literacy needs of the Hispanic population on the U.S.–Mexico border. The combination of ESL and health literacy contributed to a perceived positive learning experience among participants. Interdisciplinary approaches to health literacy are recommended. PMID:22982707

A User’s Manual for: Electromagnetic Surface Patch Code (ESP).

DTIC Science & Technology

1981-07-01

NEWMAN DAAG29-81-K-0020 UNCLASSIFIED ESL-713402- 1 AR0-17UU6.1-EL NL I OF | AD A 10 5 954 END DATE FILMED II-.8I1 DTIC SM * - III 1.0 :s...ma III ̂ ^= • ilia II I.I III— = 11.25 [I 11.4 1 ^6 t v 1 ...Ohio State University ElectroScience Laboratory Department of Electrical Engineering Columbu», Ohio 43212 Technical Report 713402- 1 Grant Number

Addressing Reticence: The Challenge of Engaging Reluctant Adult ESL Students

ERIC Educational Resources Information Center

Carter, Steven J.; Henrichsen, Lynn E.

2015-01-01

Reticence frequently prevents adult ESL learners from learning as much as they otherwise might. The nature of second-language learning requires frequent performance that may challenge students' self-concepts, leading to reticence and self-consciousness. To reduce or prevent this problem, teachers must employ appropriate pedagogical and classroom…

Teaching English Stress: A Case Study

ERIC Educational Resources Information Center

Sadat-Tehrani, Nima

2017-01-01

This article addresses the issue of teaching pronunciation in English as a second language (ESL) classes by specifically looking at the impact of teaching lexical stress rules and tendencies on learners' stress placement performance. Sixteen rules in the form of interactive worksheets were taught in three ESL classes at pre-intermediate,…

Perspectives: Using Critical Incidents to Understand ESL Student Satisfaction

ERIC Educational Resources Information Center

Walker, John

2015-01-01

In a marketized environment, ESL providers, in common with other postcompulsory educational institutions, canvass student satisfaction with their services. While the predominant method is likely to be based on tick-box questionnaires using Likert scales that measure degrees of satisfaction, qualitative methodology is an option when rich data is…

ESL Readers' Comprehension Performance: The Chinese Secondary Context

ERIC Educational Resources Information Center

Chau, Juliana; Wu, Winnie; Chen, Julia; Lughmani, Shari

2012-01-01

Recent research in reading comprehension in Western settings has focused on collecting evidence from reading tests that would measure relevant ESL reading constructs to inform reading instruction and assessment. Similar studies in non-Western contexts, however, remain under-reported. This study involved 958 senior secondary Hong Kong (Chinese)…

The Emergent Nature of Strategic Mediation in ESL Teacher Education

ERIC Educational Resources Information Center

Kaur, Kuldip

2015-01-01

This article concentrates on a practitioner-driven approach to teacher education aimed at advancing ESL teachers' instructional knowledge about writing. Based on activity-centred interaction between a group of Malaysian English teachers and their teacher educator, the discussion demonstrates (1) the emergent, unplanned nature of strategic…

Analysis of the ILR Can Do Statements as a SOFTS Placement Tool

DTIC Science & Technology

2012-09-01

Horne, A., & Van Horne, R. (2006). Promoting success of multilevel ESL classes: What teachers and administrators can do. Retrieved from www.cal.org...J. A. (1992). Bringing literacy to life: Issues and options in adult ESL literacy. San Mateo, CA: Aguirre International. SOFLO Support Project

Challenging Inquiry and Building Community: Analyzing ESL and Bilingual Teachers' Narratives

ERIC Educational Resources Information Center

Musanti, Sandra I.

2017-01-01

The study explores English as a second language (ESL) and bilingual teachers' narratives within a learning community as they collectively engage in reflecting on practices to more effectively support English learners. This longitudinal qualitative study integrates narrative inquiry approach and critical incident methodology. Participants were…

Second Language Users and Emerging English Designs

ERIC Educational Resources Information Center

Jordan, Jay

2009-01-01

As English spreads as an international language, it evolves through diverse users' writing and speaking. However, traditional views of ESL users focus on their distance from fairly static notions of English-language competence. This research uses a grounded theory approach to describe a range of competencies that emerge in ESL users' interactions…

Relative Performance of English Second Language Students in University Accounting Courses

ERIC Educational Resources Information Center

Wagner, Robin M.; Huang, Jiunn C.

2011-01-01

This paper explores the relative performances of Native English Speaking ("NES") students and English Second Language ("ESL") students in accounting courses at a large urban state university. Based upon a longitudinal study, we conclude that the relative performance between NES and ESL students depends upon the particular…

Integrating Multiple Intelligences in EFL/ESL Classrooms

ERIC Educational Resources Information Center

Bas, Gokhan

2008-01-01

This article deals with the integration of the theory of Multiple Intelligences in EFL/ESL classrooms. In this study, after the theory of multiple intelligences was presented shortly, the integration of this theory into English classrooms. Intelligence types in MI Theory were discussed and some possible application ways of these intelligence types…

Implementation of Multiple Intelligences Supported Project-Based Learning in EFL/ESL Classrooms

ERIC Educational Resources Information Center

Bas, Gokhan

2008-01-01

This article deals with the implementation of Multiple Intelligences supported Project-Based learning in EFL/ESL Classrooms. In this study, after Multiple Intelligences supported Project-based learning was presented shortly, the implementation of this learning method into English classrooms. Implementation process of MI supported Project-based…

Closed Captioned TV: A Resource for ESL Literacy Education. ERIC Digest.

ERIC Educational Resources Information Center

Parks, Carolyn

Recent technological, pedagogical, and regulatory developments have heightened awareness and appreciation of the utility of closed captioned television (CCTV) for adult English-as-a-Second-Language (ESL) and literacy instruction. A federal mandate that most televisions provide a closed caption decoder, increased captioning of all program types,…

ESL Students' Attitudes toward Punctuation

ERIC Educational Resources Information Center

Hirvela, Alan; Nussbaum, Alexander; Pierson, Herbert

2012-01-01

Punctuation is a surprisingly underexplored area of second language writing and learning. The small body of published literature about punctuation tends to look at ways in which punctuation can be taught. Little is known, except anecdotally, about how English as a second language (ESL) students actually feel about using English punctuation,…

An ESL Audio-Script Writing Workshop

ERIC Educational Resources Information Center

Miller, Carla

2012-01-01

The roles of dialogue, collaborative writing, and authentic communication have been explored as effective strategies in second language writing classrooms. In this article, the stages of an innovative, multi-skill writing method, which embeds students' personal voices into the writing process, are explored. A 10-step ESL Audio Script Writing Model…

MINNETESOL Journal, Volumes 1-12.

ERIC Educational Resources Information Center

MINNETESOL Journal, 1994

1994-01-01

The 12 volumes of the professional journal contain articles on a wide variety of topics on classroom techniques, curriculum design, class activities, and research in English-as-a-Second-Language (ESL) teaching at all educational levels. General topics include: communicating with ESL students; current events in the classroom; cultural test bias;…

Beginning English: An Instructional Guide for ESL Teachers.

ERIC Educational Resources Information Center

Brower, Lynne

An instructional guide for English as a Second Language (ESL) teachers is presented in this volume. The 18-week program contains the following modules, each of which includes sections on civics and structure: human relations; general information; housing; consumer education (money, banking, and shopping modules); occupations; health (two modules…

Discourse Approaches to Writing Assessment.

ERIC Educational Resources Information Center

Connnor, Ulla; Mbaye, Aymerou

2002-01-01

Discusses assessment of English-as-a-Foreign/Second-Language (EFL/ESL) writing. Suggests there is a considerable gap between current practices in writing assessment and criteria suggested by advances in knowledge of discourse structure. Illustrates this by contrasting current practices in the scoring of two major EFL/ESL writing tests with…

Environmental Education in a Culturally Diverse School

ERIC Educational Resources Information Center

Tangen, Donna; Fielding-Barnsley, Ruth

2007-01-01

School gardens provide a unique learning environment for English as Second Language (ESL) students; students are able to engage in experiential outdoor learning that will enhance in-class lessons. This study evaluated the effects of school gardening on ESL students' learning about good nutrition. Data collected indicated that there were positive…

University ESL Teachers' Socialization in School Workplace toward Teaching Culturally Diverse Students

ERIC Educational Resources Information Center

Huang, Hsiang-Ling

2011-01-01

Employing interpretive theory, this study investigated 331 university ESL teachers' socialization in language programs for international students. Looking beyond teacher preparatory education, in-service teachers' workplace experiences are essential to study because experience is instrumental in the shaping of belief systems (Wu and Shaffer,…

ESL: The Whole Person Approach.

ERIC Educational Resources Information Center

Ramsey, Cynthia, Ed.; Lopez, Trinidad, Ed.

This guide provides a model for training teachers of limited English proficient (LEP) students of Hispanic origins to eliminate sex bias in English-as-a-Second-Language (ESL) materials and teaching approaches. Although the guide aims primarily at the educational and personal empowerment of LEP Hispanic girls, it is also intended to assist in…

Teaching ESL Beginners Metacognitive Writing Strategies through Multimedia Software

ERIC Educational Resources Information Center

Wei, Jing; Chen, Julian Chengchiang; Adawu, Anthony

2014-01-01

This case study explores how strategy-based instruction (SBI), assisted by multimedia software, can be incorporated to teach beginning-level ESL learners metacognitive writing strategies. Two beginning-level adult learners participated in a 10-session SBI on planning and organizing strategies. The Cognitive Academic Language Learning Approach…

The Departmentalization of the ESL Program.

ERIC Educational Resources Information Center

Bolton, John K.

A review of prevailing patterns of sponsorship of college and university English as a second language (ESL) programs indicates that in community colleges, they tend to be housed in English departments. In four-year institutions they are generally in semi-autonomous units or institutes. The argument for departmental sponsorship is based on data…

Interactive ESL In-Service Teacher Training via Distance Education.

ERIC Educational Resources Information Center

Power, Michael A.

The Hawaii State Department of Education offers university credit courses in English-as-a-Second-Language (ESL) techniques to all public school teachers, but the scarcity of trainers and the distance between schools and training sites constitute substantial obstacles. With the cooperation of the University of Hawaii's interactive television…

ESL and Internationalization at Purdue University: A History and Analysis

ERIC Educational Resources Information Center

Haan, Jennifer E.

2009-01-01

With the ever growing cultural and linguistic diversity at institutions of higher education, local and institutional language planning is becoming increasingly important. By examining university policies and planning processes, ESL professionals can more appropriately advocate for their students, as well as create and implement language policies…

The SIMs Meet ESL Incorporating Authentic Computer Simulation Games into the Language Classroom

ERIC Educational Resources Information Center

Miller, Megan; Hegelheimer, Volker

2006-01-01

Despite their motivational appeal to learners, innovative and technologically advanced computer simulation games targeting native English speakers frequently remain beyond the competence of ESL learners as independent didactic tools. Guided by Chapelle's (2001) criteria for determining CALL task appropriateness, this paper illustrates how the…

English Language Testing in U.S. Colleges and Universities.

ERIC Educational Resources Information Center

Douglas, Dan, Ed.

A collection of essays and research reports addresses issues in the testing of English as a Second Language (ESL) among foreign students in United States colleges and universities. They include the following: "Overview of ESL Testing" (Ralph Pat Barrett); "English Language Testing: The View from the Admissions Office" (G. James…

L1 vs L2 Writing: ESL Graduate Students' Perceptions.

ERIC Educational Resources Information Center

Silva, Tony

1992-01-01

A classroom-based study is reported that explored English-as-a-Second Language graduate students' perceptions about (1) differences between writing in their native language and writing in English, and (2) how these difference should be reflected in ESL writing teachers' practices. (19 references) (Author/LB)

Thinking Like Researchers: An ESL Project that Investigates Local Communities

ERIC Educational Resources Information Center

McPherron, Paul; Randolph, Patrick T.

2013-01-01

Drawing on task-based and intercultural teaching approaches, this article presents an ESL classroom project at two different university settings in which students investigate aspects of their local communities through the use of ethnographic and observational research techniques. For related reasons, the instructors at each university developed…

Identifying Gaps in Academic Writing of ESL Students

ERIC Educational Resources Information Center

Giridharan, Beena

2012-01-01

There is growing evidence that the lack of competence of university ESL (English as a second language) students in academic writing affects their overall academic performance. Olivas and Li (2006) connected low second-language proficiency levels in English to poor academic performance of international students studying at both university and…

Twelve Plates of the Applesauce: ESL and TESL Students' Perspectives of Communication Partnerships.

ERIC Educational Resources Information Center

Young, Martha W.; Holmes, Vicki L.

1997-01-01

Focuses on student perspectives of communication partnerships--paired interaction--between 92 adult ESL students and TESL students, describing a tutorial experience during summer sessions at a mid-sized Southwestern university. The description includes course information, tutorial goals and guides, analyses of student-journal and tutorial…

Rapid screening of oxytetracycline residue in catfish muscle by dispersive liquid-liquid microextraction and europium-sensitized luminescence

USDA-ARS?s Scientific Manuscript database

Oxytetracycline (OTC) residue in catfish muscle was screened by dispersive liquid-liquid microextraction (DLLME) and europium-sensitized luminescence (ESL). After extraction in EDTA, HCl, and acetonitrile, cleanup was carried out by DLLME, and ESL was measured at microgram = 385 nm and wavelength = ...

Choosing and Evaluating Effective ESL Integrative Learning Systems.

ERIC Educational Resources Information Center

Careless, Paul

This paper reviews pedagogical principles surrounding learning styles that have continued to attract educators, particularly those in English as a Second Language (ESL) to Integrative Learning Systems (ILS) as a learning medium. The paper first examines the rationale for using technology in education. It briefly defines Computer-Assisted Language…

Nonnativeness

ERIC Educational Resources Information Center

Ebata, Makiko

2008-01-01

Having taught ESL/EFL for seven years has led me to believe that non-native instructors can teach English effectively since we are ESL/EFL learners ourselves. We can relate to our students through our shared difficulties and insecurities. However, a number of us face the insecurity of not being "fluent enough" to teach a language other…

Tutoring ESL: A Handbook for Volunteers.

ERIC Educational Resources Information Center

Reck, Deborah L.; And Others

This handbook is designed for use by Tacoma Community House volunteer tutors of English as a Second Language (ESL) as a supplement to basic volunteer training. The handbook includes detailed information in areas briefly covered during training and specific instructional ideas and class activities. A section on getting started discusses the…

Cohesion Features in ESL Reading: Comparing Beginning, Intermediate and Advanced Textbooks

ERIC Educational Resources Information Center

Plakans, Lia; Bilki, Zeynep

2016-01-01

This study of English as a second language (ESL) reading textbooks investigates cohesion in reading passages from 27 textbooks. The guiding research questions were whether and how cohesion differs across textbooks written for beginning, intermediate, and advanced second language readers. Using a computational tool called Coh-Metrix, textual…

Grammar Texts and Consumerist Subtexts

ERIC Educational Resources Information Center

Sokolik, M. E.

2007-01-01

While several checklists exist for the evaluation of ESL/EFL textbooks, none includes suggestions for looking for specific biases, especially those found in the content of examples and sample sentences. Growing awareness in publishing has reduced problems in the presentation of gender-based and racial biases in most ESL/EFL grammar textbooks, but…

Mother Goose in the ESL Classroom.

ERIC Educational Resources Information Center

Galeano, Karen

Mother Goose is well suited to use in the elementary ESL classroom for several reasons. The stories appeal to children's imagination, adhering to the principle that a good story should have surprise value, interesting characters, meaningful conflict, action, and realism. The natural rhythms help develop English intonation, and the stories…

Teaching ESL Content through Kite Making for Grades K-12.

ERIC Educational Resources Information Center

Alexander, N.

Ideas for teaching elementary and secondary students of English as a Second Language (ESL) through a unit on kites and kite-making are offered. First, unit objectives are outlined. These include objectives for cognitive skill development (classification, comparison), psychomotor skills (constructing a kite), mathematical operations (measuring,…

English Teachers' Moderating and Participating in OCPs

ERIC Educational Resources Information Center

Pino-Silva, Juan; Mayora, Carlos A.

2010-01-01

Online Communities of Practice (OCPs) are among the most accessible tools for EFL/ESL teachers' co-construction of knowledge and self-directed learning. Despite the welcomed proliferation of EFL/ESL teachers' OCPs, concomitant research on collaboration is noticeably lagging behind. The present paper is just a preliminary look at moderation and…

Assessing the Readability of Materials for Elementary ESL Pupils.

ERIC Educational Resources Information Center

Baldauf, Richard B., Jr.; Propst, Ivan K., Jr.

This paper assesses the effectiveness of readability indices, standard cloze procedure, and the matching cloze procedure as determinants of the readability of supplementary English materials for elementary ESL students in a Pacific Island context. A review of readability indices and the standard cloze procedure indicated that neither procedure is…

Authentic ESL Spoken Materials: Soap Opera and Sitcom versus Natural Conversation

ERIC Educational Resources Information Center

Al-Surmi, Mansoor Ali

2012-01-01

TV shows, especially soap operas and sitcoms, are usually considered by ESL practitioners as a source of authentic spoken conversational materials presumably because they reflect the linguistic features of natural conversation. However, practitioners might be faced with the dilemma of how to evaluate whether such conversational materials reflect…

Social Interactions of Speech- and Language-Impaired Children.

ERIC Educational Resources Information Center

Rice, Mabel L.; And Others

1991-01-01

This study found that 17 preschool children with limited communication skills [specific language impairment, speech impairment, and English as a Second Language (ESL)] were more likely than normal peers to initiate with adults, shorten their responses, and use nonverbal responses. ESL children were least likely to initiate interactions.…

Workplace Education Partnerships: Compromises, Promises, and Practices.

ERIC Educational Resources Information Center

Hellman, Linda

A Pima County (Arizona) adult workplace education program in English as a Second Language (ESL) is outlined. Salient elements in program design, student recruitment and program marketing, student assessment, instructional methods, and program evaluation are noted, and the topical content of the ESL curriculum is charted. Tasks/competencies and…

ESL Writing Assessment Prompts: How Students Choose.

ERIC Educational Resources Information Center

Polio, Charlene; Glew, Margo

1996-01-01

Examines how English-as-a-Second-Language (ESL) students choose a prompt from several options on a timed-writing exam. Researchers interviewed 26 students after observing them taking a writing exam. Findings indicate that students' background knowledge, question type, and topic specificity influence their decision and that time is not an…

Talking Shop: Teaching English as a Second Language in Britain.

ERIC Educational Resources Information Center

Nicholls, Sandra; Frame, Pamela

1983-01-01

The needs and motivation of short-term ESL students and immigrants are contrasted, and the wide variety of programs and services needed for immigrant English instruction is emphasized. Aspects of ESL instruction that need changing or restructuring include adult and community education, teacher training and examination, and innovative educational…

Success Structure for Accelerated Acquisition of English by Young ESL Learners

ERIC Educational Resources Information Center

Mohamed, Abdul Rashid; Tumin, Mahani; Omar, Hamzah

2008-01-01

This is an investigation into the accelerated acquisition of English among young ESL learners in an International School. It employed an ethnographic case study approach where data were gathered through non-participant observations, unstructured interviews, relevant documents, students' portfolios, field notes and biographical details. The sample…

Balancing Content & Language in the English Language Development Classroom

ERIC Educational Resources Information Center

Reynolds-Young, Danielle; Hood, Sally

2014-01-01

Although course assignments require English as a Second Language (ESL) teacher candidates to design activities, performance assessments, and lessons that balance the teaching of the English language and academic content, the ESL teacher candidates remain perplexed as to how to teach without a prescribed curriculum. The answer is challenging, given…

Uplift rates of the marine terraces in the south coast of Japan deduced from in situ cosmogenic 10Be and 26Al

NASA Astrophysics Data System (ADS)

Yokoyama, Y.; Nagano, G.; Nakamura, A.; Maemoku, H.; Miyairi, Y.; Matsuzaki, H.

2015-12-01

Marine terraces are low-relief platforms located along coastal areas. They are formed by waves action with the changes in the relative sea level (RSL) that is affected by combined effects of the eustatic sea level (ESL) and the tectonic movements (e.g. uplift, subsidence and isostatic effect). Therefore, determining the ages and the elevations of the marine terraces allows us to reconstruct the ESL and/or the tectonic history of the study area. The Kii Peninsula and the southern coast of the Shikoku Island are located along the Nankai Trough where the Philippine Sea Plate is subducting under the Eurasian plate. There exist relatively well-preserved marine terraces along the coastal line with the elevation of ca. 50 -100 m. Because of this unique tectonic setting, the terraces are regarded as the suitable counterparts to reconstruct uplift history of the south coast of Japan. However, the ages of these terraces are poorly understood due to the lack of the ash layers that is suitable for the tephrochronology. In this study, we determine the age of the marine terraces using terrestrial in-situ cosmogenic radionuclides (TCN), 10Be and 26Al. This is the first age estimation of the marine terraces in Japan using TCN, allowing us to determine the uplift rates and the seismic history of the region.

ESL TEACHER CANDIDATES' PERCEPTIONS OF STRENGTHS AND INADEQUACIES OF INSTRUCTING CULTURALLY AND LINGUISTICALLY DIVERSE STUDENTS: POST CLINICAL EXPERIENCE.

PubMed

Wong, Chiu-Yin; Indiatsi, John; Wong, Gary K W

2016-01-01

The present case study examined English as a second language (ESL) teacher candidates' views on their preparedness on instructing culturally and linguistically diverse students. A survey was administrated to a group of ESL teacher candidates at the end of the training program. Results revealed that although the participants received training in culture and instructional strategies, lacking adequate knowledge in students' diverse cultures and languages was reported as a major challenge. Personality traits and knowing specific strategies are reported as their strengths. However, there is a mismatch between the data gathered from the self-ranking component and the open-ended questions. Implications and suggestions are discussed.

The Plight of the ESL Program Director

ERIC Educational Resources Information Center

Eaton, Sarah Elaine

2008-01-01

In this presentation we will examine the situation of English as a Second Language (ESL) program managers, many of whom are charged with the responsibility of marketing their programs and recruiting students internationally, often with little or no training in how to do so (Eaton, 2005). Not only are they set forth ill-prepared, the repercussions…

The Relationships between Language Learning Strategies and Positive Emotions among Malaysian ESL Undergraduates

ERIC Educational Resources Information Center

Mohammadipour, Mohammad; Rashid, Sabariah Md; Rafik-Galea, Shameem; Thai, Yap Ngee

2018-01-01

Emotions are an indispensable part of second language learning. The aim of this study is to determine the relationship between the use of language learning strategies and positive emotions. The present study adopted a sequential mixed methods design. The participants were 300 Malaysian ESL undergraduates selected through stratified random sampling…

ESL Literacy: What's Working, Why and How--Family Literacy.

ERIC Educational Resources Information Center

Isserlis, Janet

Experiences with family and intergenerational programs in English Second Language (ESL) literacy are reviewed, and factors that contribute to their success are discussed. It is suggested that as the notion of literacy expands, conceptual boundaries of the population of learners must expand also. While there is much to be learned from existing…

Teaching for Diversity: Addressing Diversity Issues in Responsive ESL Instruction

ERIC Educational Resources Information Center

Fu, Jing

2013-01-01

Student diversity has become a typical phenomenon in American public schools. The impact of increasing diversity on literacy instruction is unchallenged. Teachers reinforce this message by often citing ESL student diversity as a barrier for literacy teaching. In order to better understand the complexity of diversity issues, I explored two ESL…

Language Teacher Identities in the Southern United States: Transforming Rural Schools

ERIC Educational Resources Information Center

Fogle, Lyn Wright; Moser, Kelly

2017-01-01

Foreign language (FL) and English as a Second Language (ESL) teaching present considerable challenges in the rural U.S. South. Local language ideologies, budgetary considerations, and challenges in other curricular areas (e.g., math and science) lead to marginalizing both FL and ESL in schools. This article examines the personal and professional…

The Role of Transitions in ESL Instruction

ERIC Educational Resources Information Center

Steinman, Linda

2013-01-01

Transitions in ESL contexts generally refer to those linking words placed between sentences and between paragraphs. Transitions in writing (and in speaking) are helpful; they facilitate coherence and cohesion when used correctly. Understanding them when reading allows us to join the writer in seeing why and how idea B follows idea A. In this…

Placement, Progress, and Promotion: ESL Assessment in California's Adult Schools

ERIC Educational Resources Information Center

Gonzalves, Lisa

2017-01-01

In California adult schools, standardized language assessments are typically administered to adult English as a second language (ESL) students upon enrollment; students then take these same state-approved tests throughout the academic year to demonstrate progress. As these tests assess only listening and reading skills, schools may use their own…

Investigating ESL Students' Performance on Outcomes Assessments in Higher Education

ERIC Educational Resources Information Center

Lakin, Joni M.; Elliott, Diane Cardenas; Liu, Ou Lydia

2012-01-01

Outcomes assessments are gaining great attention in higher education because of increased demand for accountability. These assessments are widely used by U.S. higher education institutions to measure students' college-level knowledge and skills, including students who speak English as a second language (ESL). For the past decade, the increasing…

RF Metamaterials for Foliage Penetration (FOPEN) Application

DTIC Science & Technology

2013-02-01

from LM TRACER program to develop those prototypes. Fig. 29 is an OSU prototype (#1, 7x7 array) fabricated and tested inside the ESL compact range...Fig. 29 shows the Prototype #1 under testing inside the ESL compact range. Figure 29 -Prototype #1 (7x7 Single-pol. Array) 3.2.3.1.2

The Power of Story in the ESL Classroom

ERIC Educational Resources Information Center

Nicholas, Bonnie J.; Rossiter, Marian J.; Abbott, Marilyn L.

2011-01-01

Although considerable research has examined the use of literature in the second language (L2) classroom, there has been less investigation into the integration of learners' personal stories in the English as a second language (ESL) classroom. Following Wajnryb's (2003) categorizations of story as language learning, genre, and the creation of what…

Enhancing the Impact of Evidence-Based Publications on K-12 ESL Teacher Practices

ERIC Educational Resources Information Center

Abbott, Marilyn L.; Lee, Kent; Rossiter, Marian J.

2017-01-01

The reading of current research-informed publications is an essential component of teacher professional development that has the potential to lead to or reinforce the implementation of effective instructional practices. To our knowledge, no studies have examined kindergarten to grade 12 (K-12) ESL teacher engagement in professional reading related…

A Quantitative Investigation of ESL Teacher Knowledge in Australian Adult Education

ERIC Educational Resources Information Center

Yazdanpanah, Lilly K.

2015-01-01

English as a second language (ESL) teaching is partly a thinking process in which teacher knowledge plays a pivotal role in making instructional choices (Breen, Hird, Milton, Oliver, & Thwaite, 2001). The present study contributes to understandings of teacher knowledge by exploring the types of knowledge, which practicing teachers value in…

Pedagogical Content Knowledge: A Case Study of ESL Teacher Educator

ERIC Educational Resources Information Center

Liu, Siping

2013-01-01

This single-case study focuses on the pedagogical content knowledge (PCK) of a university faculty member teaching Second Language Acquisition to elementary teacher candidates. The research questions address the pattern and development of PCK for ESL teaching. Based on data from classroom observation, interviews and document review, the study finds…

Potential of Mobile Learning in Teaching of ESL Academic Writing

ERIC Educational Resources Information Center

Zaki, Arlina Ahmad; Yunus, Melor Md

2015-01-01

The potentials of mobile learning in teaching academic writing skills for ESL students are explored in this paper. Although there have been studies on MALL to improve writing skills, academic writing was never really touched. Few aspects are covered like the changes in educational technology, defining MALL, identifying issues in academic writing…

Final Thoughts on Community in Adult ESL

ERIC Educational Resources Information Center

Larrott, Clarena

2009-01-01

Community building is an important, if not essential, element of adult English as a second language (ESL) learning. Communities, whether civic, work, religious, or identity-based, are the contexts within which people cease to be alone and become connected with others. Language is the main tool for communicating with others in communities. For…

Telling Stories of Violence in Adult ESL Classrooms: Disrupting Safe Spaces

ERIC Educational Resources Information Center

Waterhouse, Monica

2016-01-01

This article develops a complex understanding of safe space in relation to adult refugee learners' oral literacy practice of telling stories of violent life experiences in English as a second language (ESL) classrooms. A rhizoanalytic approach brings theoretical and empirical elements into conversation to ask two questions. Can the exigencies of…

Factors Affecting Teachers Utilization of Technology in Malaysian ESL Classrooms

ERIC Educational Resources Information Center

Mahmood, Foziah; Halim, Huzaina Abdul; Rajindra, Sarasvati; Ghani, Munirah Mohd

2014-01-01

Previous studies conducted by researchers show that technology utilization in the ESL classroom indeed aids students in the learning process (Snelbecker 1999). Furthermore, it also ensures that students achieve better results in English Language. Thus, this study was conducted as a stepping stone to help teachers perform better in utilizing…

Using Telephone Conversations to Develop Awareness of Pragmatic Skills: An Activity-Theory-Driven Approach

ERIC Educational Resources Information Center

Xia, Saihua

2009-01-01

This paper investigates ESL learners' awareness of pragmatic skills utilizing an activity-theory driven approach to perform an inquiry task into problem-solving service call conversations (PSSCs) between native speakers (NS) and non-native speakers of English (NNSs). Eight high-intermediate ESL learners, from five different language backgrounds,…

Online Language Teacher Education: TESOL Perspectives

ERIC Educational Resources Information Center

England, Liz, Ed.

2012-01-01

More and more, ESL/EFL teachers are required by their employers to obtain a Master's degree in TESOL. Thousands of ESL/EFL teachers are acquiring professional skills and knowledge through online and distance education instructional models. Filling a growing need and making an important contribution, this book is a forerunner in addressing some of…

Extent of ESL Teachers' Access To, Utilisation and Production of Research

ERIC Educational Resources Information Center

Sibanda, Jabulani; Begede, Martin P.

2015-01-01

This study employed the survey design on a purposive sample of 100 English Second Language (ESL) teachers from Swaziland and South Africa's Eastern Cape Province, to investigate the extent to which they accessed, utilised and conducted research to better their practice. A survey questionnaire and follow-up structured interviews generated…

Cross-District Collaboration: Curriculum and Professional Development

ERIC Educational Resources Information Center

Short, Deborah J.; Cloud, Nancy; Morris, Patricia; Motta, Julie

2012-01-01

Secondary English as a second language (ESL) curricula that address four levels of ESL proficiency and prepare students for the English language arts (ELA) curricula and state-mandated ELA tests are not common. A curriculum jointly developed by two districts is even rarer. Yet two urban districts in Rhode Island undertook such a curriculum…

Folklore in ESL/EFL Curriculum Materials.

ERIC Educational Resources Information Center

Pedersen, E. Martin

It is argued that folklore can and should have a primary place in curriculum for English as a Second Language (ESL) and English as a Foreign Language (EFL). Folklore has the following advantages--it: is a form of literature in which language, arts, and culture intersect; fosters understanding and acceptance of the foreign language and culture; can…

"Is Everybody Getting It?": Sustained Support for English as a Second Language Students

ERIC Educational Resources Information Center

Henderson, Paulette A.

2009-01-01

As English as Second Language (ESL) students move past their first college year toward degree completion, they may find themselves struggling on their own. This article describes one community college's approach to supporting ESL students throughout their academic career. English as a Second Language Across the Curriculum (ESLAC) provides…

English Pyramids: Using Hierarchical Diagrams for Communication Activities.

ERIC Educational Resources Information Center

Johnson, Tia; Sheetz-Brunetti, Judy

The pyramid, or hierarchical diagram, is used in teaching writing English as a second language (ESL) as a visual representation of the way English speakers and writers organize ideas, for comparison with discourse organization in other cultures. A common problem of ESL students is an inability to organize ideas hierarchically. One class activity…

Investigating ESL Students' Academic Performance in Tenses

ERIC Educational Resources Information Center

Javed, Muhammad; Ahmad, Atezaz

2013-01-01

The present study intends to assess the ESL students' performance in tenses at secondary school level. Grade 10 students were the target population of the study. A sample of 396 students (255 male and 141 female) was selected through convenience sampling technique from the District of Bahawalnagar, Pakistan. A test focusing on five different types…

Maximising Asian ESL Learners' Communicative Oral English via Drama

ERIC Educational Resources Information Center

Gill, Chamkaur

2016-01-01

This paper proposes that activities based on a variety of drama-based techniques could be valuable in giving Asian ESL learners opportunities to use communicative spoken English confidently and without restraint during their time in English-language-speaking countries. These learners often get anxious when in situations where they are required to…

An Adult ESL Curriculum.

ERIC Educational Resources Information Center

South Carolina Literacy Resource Center, Columbia.

This curriculum framework for adult literacy was written by 21 South Carolina adult English-as-a-Second-Language (ESL) instructors, as submitted to the South Carolina Literacy Resource Center. It is based on current theories in the fields of adult education and second language acquisition and is designed to be flexible so that it may be adapted to…

Adult Hispanic ESL Students and Graded Readers

ERIC Educational Resources Information Center

Martinez, Liza E.

2017-01-01

This study examined the extent to which graded readers vis-à-vis scaffolded silent reading (ScSR) resulted in increased vocabulary, reading comprehension, and a positive attitude toward reading. A mixed-methods study was administered to two upper-intermediate adult ESL classes at a community college in southwestern Arizona. Both groups took The…

Alternative Outlining Techniques for ESL Composition.

ERIC Educational Resources Information Center

Hubbard, Philip

Two methods of outlining are suggested for college-level students of English as a second language (ESL) who need the tools to master rhetorical patterns of academic written English that may be very different from those in their native languages. The two outlining techniques separate the four logically distinct tasks in the process of outlining:…

Teaching L2 Pragmatics: Opportunities for Continuing Professional Development

ERIC Educational Resources Information Center

Vellenga, Heidi

2011-01-01

Teaching L2 pragmatics is often not covered in teacher education programs, and is an excellent area for continuing professional development. As part of a larger project on instructed interlanguage pragmatics, volunteer instructor participants were asked to teach a series of lessons on pragmatics to university-aged (19-23) ESL learners in ESL and…

Scientific Structural Changes within Texts of Adapted Reading Materials

ERIC Educational Resources Information Center

Aziz, Anealka; Fook, Chan Yuen; Alsree, Zubaidah

2010-01-01

ESL instructors generally use ready-made reading materials in commercially published coursebooks. However, it would be more effective for learners if ESL instructors are involved in developing reading materials for them. This is because they are closer, more sensitive and responsive to the needs of their learners and they are also aware of the…

Concordancers and Dictionaries as Problem-Solving Tools for ESL Academic Writing

ERIC Educational Resources Information Center

Yoon, Choongil

2016-01-01

The present study investigated how 6 Korean ESL graduate students in Canada used a suite of freely available reference resources, consisting of Web-based corpus tools, Google search engines, and dictionaries, for solving linguistic problems while completing an authentic academic writing assignment in English. Using a mixed methods design, the…

Determining the Debilitative Impact of Test Anxiety.

ERIC Educational Resources Information Center

Madsen, Harold S.

The detrimental effects of anxiety in English as a second language/foreign language (ESL/FL) are investigated. Although empirical research on the subject of ESL/FL test affect is limited, helpful insights on test anxiety exist in the psychological literature. Two constructs in the anxiety literature are considered relevant for this study: trait…