Global fishery development patterns are driven by profit but not trophic level

PubMed Central

Sethi, Suresh A.; Branch, Trevor A.; Watson, Reg

2010-01-01

Successful ocean management needs to consider not only fishing impacts but drivers of harvest. Consolidating post-1950 global catch and economic data, we assess which attributes of fisheries are good indicators for fishery development. Surprisingly, year of development and economic value are not correlated with fishery trophic levels. Instead, patterns emerge of profit-driven fishing for attributes related to costs and revenues. Post-1950 fisheries initially developed on shallow ranging species with large catch, high price, and big body size, and then expanded to less desirable species. Revenues expected from developed fisheries declined 95% from 1951 to 1999, and few high catch or valuable fishing opportunities remain. These results highlight the importance of economic attributes of species as leading indicators for harvest-related impacts in ocean ecosystems. PMID:20566867

Impact of predator dormancy on prey-predator dynamics

NASA Astrophysics Data System (ADS)

Freire, Joana G.; Gallas, Marcia R.; Gallas, Jason A. C.

2018-05-01

The impact of predator dormancy on the population dynamics of phytoplankton-zooplankton in freshwater ecosystems is investigated using a simple model including dormancy, a strategy to avoid extinction. In addition to recently reported chaos-mediated mixed-mode oscillations, as the carrying capacity grows, we find surprisingly wide phases of nonchaos-mediated mixed-mode oscillations to be present well before the onset of chaos in the system. Nonchaos-mediated cascades display spike-adding sequences, while chaos-mediated cascades show spike-doubling. A host of braided periodic phases with exotic shapes is found embedded in a region of control parameters dominated by chaotic oscillations. We describe the organization of these complicated phases and show how they are interconnected and how their complexity unfolds as control parameters change. The novel nonchaos-mediated phases are found to be large and stable, even for low carrying capacity.

Morality in everyday life.

PubMed

Hofmann, Wilhelm; Wisneski, Daniel C; Brandt, Mark J; Skitka, Linda J

2014-09-12

The science of morality has drawn heavily on well-controlled but artificial laboratory settings. To study everyday morality, we repeatedly assessed moral or immoral acts and experiences in a large (N = 1252) sample using ecological momentary assessment. Moral experiences were surprisingly frequent and manifold. Liberals and conservatives emphasized somewhat different moral dimensions. Religious and nonreligious participants did not differ in the likelihood or quality of committed moral and immoral acts. Being the target of moral or immoral deeds had the strongest impact on happiness, whereas committing moral or immoral deeds had the strongest impact on sense of purpose. Analyses of daily dynamics revealed evidence for both moral contagion and moral licensing. In sum, morality science may benefit from a closer look at the antecedents, dynamics, and consequences of everyday moral experience. Copyright © 2014, American Association for the Advancement of Science.

Impact of spot charge inaccuracies in IMPT treatments.

PubMed

Kraan, Aafke C; Depauw, Nicolas; Clasie, Ben; Giunta, Marina; Madden, Tom; Kooy, Hanne M

2017-08-01

Spot charge is one parameter of pencil-beam scanning dose delivery system whose accuracy is typically high but whose required value has not been investigated. In this work we quantify the dose impact of spot charge inaccuracies on the dose distribution in patients. Knowing the effect of charge errors is relevant for conventional proton machines, as well as for new generation proton machines, where ensuring accurate charge may be challenging. Through perturbation of spot charge in treatment plans for seven patients and a phantom, we evaluated the dose impact of absolute (up to 5× 10 6 protons) and relative (up to 30%) charge errors. We investigated the dependence on beam width by studying scenarios with small, medium and large beam sizes. Treatment plan statistics included the Γ passing rate, dose-volume-histograms and dose differences. The allowable absolute charge error for small spot plans was about 2× 10 6 protons. Larger limits would be allowed if larger spots were used. For relative errors, the maximum allowable error size for small, medium and large spots was about 13%, 8% and 6% for small, medium and large spots, respectively. Dose distributions turned out to be surprisingly robust against random spot charge perturbation. Our study suggests that ensuring spot charge errors as small as 1-2% as is commonly aimed at in conventional proton therapy machines, is clinically not strictly needed. © 2017 American Association of Physicists in Medicine.

Modeling the potential impact of seasonal and inactive multi-aquifer wells on contaminant movement to public water-supply wells

USGS Publications Warehouse

Johnson, R.L.; Clark, B.R.; Landon, M.K.; Kauffman, L.J.; Eberts, S.M.

2011-01-01

Wells screened across multiple aquifers can provide pathways for the movement of surprisingly large volumes of groundwater to confined aquifers used for public water supply (PWS). Using a simple numerical model, we examine the impact of several pumping scenarios on leakage from an unconfined aquifer to a confined aquifer and conclude that a single inactive multi-aquifer well can contribute nearly 10% of total PWS well flow over a wide range of pumping rates. This leakage can occur even when the multi-aquifer well is more than a kilometer from the PWS well. The contribution from multi-aquifer wells may be greater under conditions where seasonal pumping (e.g., irrigation) creates large, widespread downward hydraulic gradients between aquifers. Under those conditions, water can continue to leak down a multi-aquifer well from an unconfined aquifer to a confined aquifer even when those multi-aquifer wells are actively pumped. An important implication is that, if an unconfined aquifer is contaminated, multi-aquifer wells can increase the vulnerability of a confined-aquifer PWS well.

The Nucleus of Comet 67P/Churyumov-Gerasimenko: Lots of Surprises

NASA Astrophysics Data System (ADS)

Weissman, Paul R.; Rosetta Science Working Team

2016-10-01

ESA's Rosetta mission has made many new and unexpected discoveries since its arrival at comet 67P/Churyumov-Gerasimenko in August 2014. The first of these was the unusual shape of the cometary nucleus. Although bilobate nuclei had been seen before, the extreme concavities on 67P were unexpected. Evidence gathered during the mission suggests that two independent bodies came together to form 67P, rather than the nucleus being a single body that was sculpted by sublimation and/or other processes. Although not a surprise, early observations showed that the nucleus rotation period had decreased by ~22 minutes since the previous aphelion passage. A similar rotation period decrease was seen post-perihelion during the encounter. These changes likely arise from asymmetric jetting forces from the irregular nucleus. Initially, Rosetta's instruments found little evidence for water ice on the surface; the presence of surface water ice increased substantially as the nucleus approached perihelion. The nucleus bulk density, 533 ± 6 kg/m3, was measured with Radio Science and OSIRIS imaging of the nucleus volume. This confirmed previous estimates based on indirect methods that the bulk density of cometary nuclei was on the order of 500-600 kg/m3 and on measurement of the density of 9P/Tempel 1's nucleus by Deep Impact. Nucleus topography proved to be highly varied, from smooth dust-covered plains to shallow circular basins, to the very rough terrain where the Philae lander came to rest. Evidence of thermal cracking is everywhere. The discovery of cylindrical pits on the surface, typically 100-200m in diameter with similar depths was a major surprise and has been interpreted as sinkholes. "Goose-bump" terrain consisting of apparently random piles of boulders 2-3 m in diameter was another unexpected discovery. Apparent layering with scales of meters to many tens of meters was seen but there was little or no evidence for impact features. Radar tomography of the interior of the "head" of the nucleus showed no evidence of large voids, > 100's of meters, in the interior and the RSI experiment also ruled out large voids > 600m in size. This work was supported by the U.S. Rosetta Project, funded by NASA.

Distinct medial temporal networks encode surprise during motivation by reward versus punishment

PubMed Central

Murty, Vishnu P.; LaBar, Kevin S.; Adcock, R. Alison

2016-01-01

Adaptive motivated behavior requires predictive internal representations of the environment, and surprising events are indications for encoding new representations of the environment. The medial temporal lobe memory system, including the hippocampus and surrounding cortex, encodes surprising events and is influenced by motivational state. Because behavior reflects the goals of an individual, we investigated whether motivational valence (i.e., pursuing rewards versus avoiding punishments) also impacts neural and mnemonic encoding of surprising events. During functional magnetic resonance imaging (fMRI), participants encountered perceptually unexpected events either during the pursuit of rewards or avoidance of punishments. Despite similar levels of motivation across groups, reward and punishment facilitated the processing of surprising events in different medial temporal lobe regions. Whereas during reward motivation, perceptual surprises enhanced activation in the hippocampus, during punishment motivation surprises instead enhanced activation in parahippocampal cortex. Further, we found that reward motivation facilitated hippocampal coupling with ventromedial PFC, whereas punishment motivation facilitated parahippocampal cortical coupling with orbitofrontal cortex. Behaviorally, post-scan testing revealed that reward, but not punishment, motivation resulted in greater memory selectivity for surprising events encountered during goal pursuit. Together these findings demonstrate that neuromodulatory systems engaged by anticipation of reward and punishment target separate components of the medial temporal lobe, modulating medial temporal lobe sensitivity and connectivity. Thus, reward and punishment motivation yield distinct neural contexts for learning, with distinct consequences for how surprises are incorporated into predictive mnemonic models of the environment. PMID:26854903

Distinct medial temporal networks encode surprise during motivation by reward versus punishment.

PubMed

Murty, Vishnu P; LaBar, Kevin S; Adcock, R Alison

2016-10-01

Adaptive motivated behavior requires predictive internal representations of the environment, and surprising events are indications for encoding new representations of the environment. The medial temporal lobe memory system, including the hippocampus and surrounding cortex, encodes surprising events and is influenced by motivational state. Because behavior reflects the goals of an individual, we investigated whether motivational valence (i.e., pursuing rewards versus avoiding punishments) also impacts neural and mnemonic encoding of surprising events. During functional magnetic resonance imaging (fMRI), participants encountered perceptually unexpected events either during the pursuit of rewards or avoidance of punishments. Despite similar levels of motivation across groups, reward and punishment facilitated the processing of surprising events in different medial temporal lobe regions. Whereas during reward motivation, perceptual surprises enhanced activation in the hippocampus, during punishment motivation surprises instead enhanced activation in parahippocampal cortex. Further, we found that reward motivation facilitated hippocampal coupling with ventromedial PFC, whereas punishment motivation facilitated parahippocampal cortical coupling with orbitofrontal cortex. Behaviorally, post-scan testing revealed that reward, but not punishment, motivation resulted in greater memory selectivity for surprising events encountered during goal pursuit. Together these findings demonstrate that neuromodulatory systems engaged by anticipation of reward and punishment target separate components of the medial temporal lobe, modulating medial temporal lobe sensitivity and connectivity. Thus, reward and punishment motivation yield distinct neural contexts for learning, with distinct consequences for how surprises are incorporated into predictive mnemonic models of the environment. Copyright © 2016 Elsevier Inc. All rights reserved.

Modulating Human Auditory Processing by Transcranial Electrical Stimulation

PubMed Central

Heimrath, Kai; Fiene, Marina; Rufener, Katharina S.; Zaehle, Tino

2016-01-01

Transcranial electrical stimulation (tES) has become a valuable research tool for the investigation of neurophysiological processes underlying human action and cognition. In recent years, striking evidence for the neuromodulatory effects of transcranial direct current stimulation, transcranial alternating current stimulation, and transcranial random noise stimulation has emerged. While the wealth of knowledge has been gained about tES in the motor domain and, to a lesser extent, about its ability to modulate human cognition, surprisingly little is known about its impact on perceptual processing, particularly in the auditory domain. Moreover, while only a few studies systematically investigated the impact of auditory tES, it has already been applied in a large number of clinical trials, leading to a remarkable imbalance between basic and clinical research on auditory tES. Here, we review the state of the art of tES application in the auditory domain focussing on the impact of neuromodulation on acoustic perception and its potential for clinical application in the treatment of auditory related disorders. PMID:27013969

Impacts of feral horses on a desert environment

PubMed Central

2009-01-01

Background Free-ranging horses (Equus caballus) in North America are considered to be feral animals since they are descendents of non-native domestic horses introduced to the continent. We conducted a study in a southern California desert to understand how feral horse movements and horse feces impacted this arid ecosystem. We evaluated five parameters susceptible to horse trampling: soil strength, vegetation cover, percent of nonnative vegetation, plant species diversity, and macroinvertebrate abundance. We also tested whether or not plant cover and species diversity were affected by the presence of horse feces. Results Horse trailing resulted in reduced vegetation cover, compacted soils, and in cases of intermediate intensity disturbance, increased plant species diversity. The presence of horse feces did not affect plant cover, but it did increase native plant diversity. Conclusion Adverse impacts, such as soil compaction and increased erosion potential, were limited to established horse trails. In contrast, increased native plant diversity near trails and feces could be viewed as positive outcomes. Extensive trailing can result in a surprisingly large impact area: we estimate that < 30 horses used > 25 km2 of trails in our study area. PMID:19903355

Impacts of feral horses on a desert environment.

PubMed

Ostermann-Kelm, Stacey D; Atwill, Edward A; Rubin, Esther S; Hendrickson, Larry E; Boyce, Walter M

2009-11-10

Free-ranging horses (Equus caballus) in North America are considered to be feral animals since they are descendents of non-native domestic horses introduced to the continent. We conducted a study in a southern California desert to understand how feral horse movements and horse feces impacted this arid ecosystem. We evaluated five parameters susceptible to horse trampling: soil strength, vegetation cover, percent of nonnative vegetation, plant species diversity, and macroinvertebrate abundance. We also tested whether or not plant cover and species diversity were affected by the presence of horse feces. Horse trailing resulted in reduced vegetation cover, compacted soils, and in cases of intermediate intensity disturbance, increased plant species diversity. The presence of horse feces did not affect plant cover, but it did increase native plant diversity. Adverse impacts, such as soil compaction and increased erosion potential, were limited to established horse trails. In contrast, increased native plant diversity near trails and feces could be viewed as positive outcomes. Extensive trailing can result in a surprisingly large impact area: we estimate that < 30 horses used > 25 km2 of trails in our study area.

The Large Scale Distribution of Water Ice in the Polar Regions of the Moon

NASA Astrophysics Data System (ADS)

Jordan, A.; Wilson, J. K.; Schwadron, N.; Spence, H. E.

2017-12-01

For in situ resource utilization, one must know where water ice is on the Moon. Many datasets have revealed both surface deposits of water ice and subsurface deposits of hydrogen near the lunar poles, but it has proved difficult to resolve the differences among the locations of these deposits. Despite these datasets disagreeing on how deposits are distributed on small scales, we show that most of these datasets do agree on the large scale distribution of water ice. We present data from the Cosmic Ray Telescope for the Effects of Radiation (CRaTER) on the Lunar Reconnaissance Orbiter (LRO), LRO's Lunar Exploration Neutron Detector (LEND), the Neutron Spectrometer on Lunar Prospector (LPNS), LRO's Lyman Alpha Mapping Project (LAMP), LRO's Lunar Orbiter Laser Altimeter (LOLA), and Chandrayaan-1's Moon Mineralogy Mapper (M3). All, including those that show clear evidence for water ice, reveal surprisingly similar trends with latitude, suggesting that both surface and subsurface datasets are measuring ice. All show that water ice increases towards the poles, and most demonstrate that its signature appears at about ±70° latitude and increases poleward. This is consistent with simulations of how surface and subsurface cold traps are distributed with latitude. This large scale agreement constrains the origin of the ice, suggesting that an ancient cometary impact (or impacts) created a large scale deposit that has been rendered locally heterogeneous by subsequent impacts. Furthermore, it also shows that water ice may be available down to ±70°—latitudes that are more accessible than the poles for landing.

What Explains Patterns of Diversification and Richness among Animal Phyla?

PubMed Central

Jezkova, Tereza; Wiens, John J.

2016-01-01

Animal phyla vary dramatically in species richness (from 1 species to >1.2 million), but the causes of this variation remain largely unknown. Animals have also evolved striking variation in morphology and ecology, including sessile marine taxa lacking heads, eyes, limbs, and complex organs (e.g. sponges), parasitic worms (e.g. nematodes, platyhelminths), and taxa with eyes, skeletons, limbs, and complex organs that dominate terrestrial ecosystems (arthropods, chordates). Relating this remarkable variation in traits to the diversification and richness of animal phyla is a fundamental yet unresolved problem in biology. Here, we test the impacts of 18 traits (including morphology, ecology, reproduction, and development) on diversification and richness of extant animal phyla. Using phylogenetic multiple regression, the best-fitting model includes five traits that explain ~74% of the variation in diversification rates (dioecy, parasitism, eyes/photoreceptors, a skeleton, non-marine habitat). However, a model including just three (skeleton, parasitism, habitat) explains nearly as much variation (~67%). Diversification rates then largely explain richness patterns. Our results also identify many striking traits that have surprisingly little impact on diversification (e.g. head, limbs, and complex circulatory and digestive systems). Overall, our results reveal the key factors that shape large-scale patterns of diversification and richness across >80% of all extant, described species. PMID:28221832

What Explains Patterns of Diversification and Richness among Animal Phyla?

PubMed

Jezkova, Tereza; Wiens, John J

2017-03-01

Animal phyla vary dramatically in species richness (from one species to >1.2 million), but the causes of this variation remain largely unknown. Animals have also evolved striking variation in morphology and ecology, including sessile marine taxa lacking heads, eyes, limbs, and complex organs (e.g., sponges), parasitic worms (e.g., nematodes, platyhelminths), and taxa with eyes, skeletons, limbs, and complex organs that dominate terrestrial ecosystems (arthropods, chordates). Relating this remarkable variation in traits to the diversification and richness of animal phyla is a fundamental yet unresolved problem in biology. Here, we test the impacts of 18 traits (including morphology, ecology, reproduction, and development) on diversification and richness of extant animal phyla. Using phylogenetic multiple regression, the best-fitting model includes five traits that explain ∼74% of the variation in diversification rates (dioecy, parasitism, eyes/photoreceptors, a skeleton, nonmarine habitat). However, a model including just three (skeleton, parasitism, habitat) explains nearly as much variation (∼67%). Diversification rates then largely explain richness patterns. Our results also identify many striking traits that have surprisingly little impact on diversification (e.g., head, limbs, and complex circulatory and digestive systems). Overall, our results reveal the key factors that shape large-scale patterns of diversification and richness across >80% of all extant, described species.

Computational psychiatry

PubMed Central

Montague, P. Read; Dolan, Raymond J.; Friston, Karl J.; Dayan, Peter

2013-01-01

Computational ideas pervade many areas of science and have an integrative explanatory role in neuroscience and cognitive science. However, computational depictions of cognitive function have had surprisingly little impact on the way we assess mental illness because diseases of the mind have not been systematically conceptualized in computational terms. Here, we outline goals and nascent efforts in the new field of computational psychiatry, which seeks to characterize mental dysfunction in terms of aberrant computations over multiple scales. We highlight early efforts in this area that employ reinforcement learning and game theoretic frameworks to elucidate decision-making in health and disease. Looking forwards, we emphasize a need for theory development and large-scale computational phenotyping in human subjects. PMID:22177032

Did Hurricane Sandy influence the 2012 US presidential election?

PubMed

Hart, Joshua

2014-07-01

Despite drawing on a common pool of data, observers of the 2012 presidential campaign came to different conclusions about whether, how, and to what extent "October surprise" Hurricane Sandy influenced the election. The present study used a mixed correlational and experimental design to assess the relation between, and effect of, the salience of Hurricane Sandy on attitudes and voting intentions regarding President Barack Obama and Mitt Romney in a large sample of voting-aged adults. Results suggest that immediately following positive news coverage of Obama's handling of the storm's aftermath, Sandy's salience positively influenced attitudes toward Obama, but that by election day, reminders of the hurricane became a drag instead of a boon for the President. In addition to theoretical implications, this study provides an example of how to combine methodological approaches to help answer questions about the impact of unpredictable, large-scale events as they unfold. Copyright © 2014 Elsevier Inc. All rights reserved.

The Mechanism of Impact of Summative Assessment on Medical Students' Learning

ERIC Educational Resources Information Center

Cilliers, Francois J.; Schuwirth, Lambert W.; Adendorff, Hanelie J.; Herman, Nicoline; van der Vleuten, Cees P.

2010-01-01

It has become axiomatic that assessment impacts powerfully on student learning, but there is a surprising dearth of research on how. This study explored the mechanism of impact of summative assessment on the process of learning of theory in higher education. Individual, in-depth interviews were conducted with medical students and analyzed…

How jet lag impairs Major League Baseball performance.

PubMed

Song, Alex; Severini, Thomas; Allada, Ravi

2017-02-07

Laboratory studies have demonstrated that circadian clocks align physiology and behavior to 24-h environmental cycles. Examination of athletic performance has been used to discern the functions of these clocks in humans outside of controlled settings. Here, we examined the effects of jet lag, that is, travel that shifts the alignment of 24-h environmental cycles relative to the endogenous circadian clock, on specific performance metrics in Major League Baseball. Accounting for potential differences in home and away performance, travel direction, and team confounding variables, we observed that jet-lag effects were largely evident after eastward travel with very limited effects after westward travel, consistent with the >24-h period length of the human circadian clock. Surprisingly, we found that jet lag impaired major parameters of home-team offensive performance, for example, slugging percentage, but did not similarly affect away-team offensive performance. On the other hand, jet lag impacted both home and away defensive performance. Remarkably, the vast majority of these effects for both home and away teams could be explained by a single measure, home runs allowed. Rather than uniform effects, these results reveal surprisingly specific effects of circadian misalignment on athletic performance under natural conditions.

How jet lag impairs Major League Baseball performance

PubMed Central

Song, Alex; Severini, Thomas; Allada, Ravi

2017-01-01

Laboratory studies have demonstrated that circadian clocks align physiology and behavior to 24-h environmental cycles. Examination of athletic performance has been used to discern the functions of these clocks in humans outside of controlled settings. Here, we examined the effects of jet lag, that is, travel that shifts the alignment of 24-h environmental cycles relative to the endogenous circadian clock, on specific performance metrics in Major League Baseball. Accounting for potential differences in home and away performance, travel direction, and team confounding variables, we observed that jet-lag effects were largely evident after eastward travel with very limited effects after westward travel, consistent with the >24-h period length of the human circadian clock. Surprisingly, we found that jet lag impaired major parameters of home-team offensive performance, for example, slugging percentage, but did not similarly affect away-team offensive performance. On the other hand, jet lag impacted both home and away defensive performance. Remarkably, the vast majority of these effects for both home and away teams could be explained by a single measure, home runs allowed. Rather than uniform effects, these results reveal surprisingly specific effects of circadian misalignment on athletic performance under natural conditions. PMID:28115724

Intuitive biological thought: Developmental changes and effects of biology education in late adolescence.

PubMed

Coley, John D; Arenson, Melanie; Xu, Yian; Tanner, Kimberly D

2017-02-01

A large body of cognitive research has shown that people intuitively and effortlessly reason about the biological world in complex and systematic ways. We addressed two questions about the nature of intuitive biological reasoning: How does intuitive biological thinking change during adolescence and early adulthood? How does increasing biology education influence intuitive biological thinking? To do so, we developed a battery of measures to systematically test three components of intuitive biological thought: anthropocentric thinking, teleological thinking and essentialist thinking, and tested 8th graders and university students (both biology majors, and non-biology majors). Results reveal clear evidence of persistent intuitive reasoning among all populations studied, consistent but surprisingly small differences between 8th graders and college students on measures of intuitive biological thought, and consistent but again surprisingly small influence of increasing biology education on intuitive biological reasoning. Results speak to the persistence of intuitive reasoning, the importance of taking intuitive knowledge into account in science classrooms, and the necessity of interdisciplinary research to advance biology education. Further studies are necessary to investigate how cultural context and continued acquisition of expertise impact intuitive biology thinking. Copyright © 2016 Elsevier Inc. All rights reserved.

Crowding Induces Complex Ergodic Diffusion and Dynamic Elongation of Large DNA Molecules

PubMed Central

Chapman, Cole D.; Gorczyca, Stephanie; Robertson-Anderson, Rae M.

2015-01-01

Despite the ubiquity of molecular crowding in living cells, the effects of crowding on the dynamics of genome-sized DNA are poorly understood. Here, we track single, fluorescent-labeled large DNA molecules (11, 115 kbp) diffusing in dextran solutions that mimic intracellular crowding conditions (0–40%), and determine the effects of crowding on both DNA mobility and conformation. Both DNAs exhibit ergodic Brownian motion and comparable mobility reduction in all conditions; however, crowder size (10 vs. 500 kDa) plays a critical role in the underlying diffusive mechanisms and dependence on crowder concentration. Surprisingly, in 10-kDa dextran, crowder influence saturates at ∼20% with an ∼5× drop in DNA diffusion, in stark contrast to exponentially retarded mobility, coupled to weak anomalous subdiffusion, with increasing concentration of 500-kDa dextran. Both DNAs elongate into lower-entropy states (compared to random coil conformations) when crowded, with elongation states that are gamma distributed and fluctuate in time. However, the broadness of the distribution of states and the time-dependence and length scale of elongation length fluctuations depend on both DNA and crowder size with concentration having surprisingly little impact. Results collectively show that mobility reduction and coil elongation of large crowded DNAs are due to a complex interplay between entropic effects and crowder mobility. Although elongation and initial mobility retardation are driven by depletion interactions, subdiffusive dynamics, and the drastic exponential slowing of DNA, up to ∼300×, arise from the reduced mobility of larger crowders. Our results elucidate the highly important and widely debated effects of cellular crowding on genome-sized DNA. PMID:25762333

Commentary: Gaze Aversion and Unnoticed Phenomena.

PubMed

Runyan, Desmond K

2018-03-28

Child abuse is a social phenomenon that has been under-researched and under-supported. The scale of the problem is large with over 3 million US children reported for abuse or neglect each year. An estimated 15% of confirmed victims may be placed in out-of-home care to ensure their safety. Studies have not previously examined the impact of losing a child into foster care on maternal health and mortality. Family and maternal risk factors, such as teen pregnancy, intimate partner violence or drug and alcohol abuse, have been well documented as risk factors for maltreatment. The findings of Wall-Wieler, et al. are not so much unexpected as they are surprising in that the impact of foster care on maternal health has heretofore been largely unexamined. The innovative use of maternal sisters with children not in foster care as controls provides a powerful control for family genetics, and family environment with likely common early life experiences, in the mortality of the mothers whose children were removed. With over 3 million children reported for suspected maltreatment each year, the related health and social outcomes for both children and their families require more careful examination using public health methods.

Queen Quality and the Impact of Honey Bee Diseases on Queen Health: Potential for Interactions between Two Major Threats to Colony Health.

PubMed

Amiri, Esmaeil; Strand, Micheline K; Rueppell, Olav; Tarpy, David R

2017-05-08

Western honey bees, Apis mellifera , live in highly eusocial colonies that are each typically headed by a single queen. The queen is the sole reproductive female in a healthy colony, and because long-term colony survival depends on her ability to produce a large number of offspring, queen health is essential for colony success. Honey bees have recently been experiencing considerable declines in colony health. Among a number of biotic and abiotic factors known to impact colony health, disease and queen failure are repeatedly reported as important factors underlying colony losses. Surprisingly, there are relatively few studies on the relationship and interaction between honey bee diseases and queen quality. It is critical to understand the negative impacts of pests and pathogens on queen health, how queen problems might enable disease, and how both factors influence colony health. Here, we review the current literature on queen reproductive potential and the impacts of honey bee parasites and pathogens on queens. We conclude by highlighting gaps in our knowledge on the combination of disease and queen failure to provide a perspective and prioritize further research to mitigate disease, improve queen quality, and ensure colony health.

Teledesic Global Wireless Broadband Network: Space Infrastructure Architecture, Design Features and Technologies

NASA Technical Reports Server (NTRS)

Stuart, James R.

1995-01-01

The Teledesic satellites are a new class of small satellites which demonstrate the important commercial benefits of using technologies developed for other purposes by U.S. National Laboratories. The Teledesic satellite architecture, subsystem design features, and new technologies are described. The new Teledesic satellite manufacturing, integration, and test approaches which use modern high volume production techniques and result in surprisingly low space segment costs are discussed. The constellation control and management features and attendant software architecture features are addressed. After briefly discussing the economic and technological impact on the USA commercial space industries of the space communications revolution and such large constellation projects, the paper concludes with observations on the trend toward future system architectures using networked groups of much smaller satellites.

Variables Impacting Dispositional Empathy in Doctoral Psychology Students

ERIC Educational Resources Information Center

Micheli, Amelia C.

2014-01-01

The purpose of this study was to explore variables impacting dispositional empathy in doctoral psychology students. While there is a great deal of research regarding empathy in practicing psychologists and mental health professionals, little is known about empathy in psychology trainees. This is especially surprising given the importance of…

Lexical Predictability During Natural Reading: Effects of Surprisal and Entropy Reduction.

PubMed

Lowder, Matthew W; Choi, Wonil; Ferreira, Fernanda; Henderson, John M

2018-06-01

What are the effects of word-by-word predictability on sentence processing times during the natural reading of a text? Although information complexity metrics such as surprisal and entropy reduction have been useful in addressing this question, these metrics tend to be estimated using computational language models, which require some degree of commitment to a particular theory of language processing. Taking a different approach, this study implemented a large-scale cumulative cloze task to collect word-by-word predictability data for 40 passages and compute surprisal and entropy reduction values in a theory-neutral manner. A separate group of participants read the same texts while their eye movements were recorded. Results showed that increases in surprisal and entropy reduction were both associated with increases in reading times. Furthermore, these effects did not depend on the global difficulty of the text. The findings suggest that surprisal and entropy reduction independently contribute to variation in reading times, as these metrics seem to capture different aspects of lexical predictability. Copyright © 2018 Cognitive Science Society, Inc.

Biospectroscopy reveals the effect of varying water quality on tadpole tissues of the common frog (Rana temporaria).

PubMed

Strong, Rebecca J; Halsall, Crispin J; Ferenčík, Martin; Jones, Kevin C; Shore, Richard F; Martin, Francis L

2016-06-01

Amphibians are undergoing large population declines in many regions around the world. As environmental pollution from both agricultural and urban sources has been implicated in such declines, there is a need for a biomonitoring approach to study potential impacts on this vulnerable class of organism. This study assessed the use of infrared (IR) spectroscopy as a tool to detect changes in several tissues (liver, muscle, kidney, heart and skin) of late-stage common frog (Rana temporaria) tadpoles collected from ponds with differing water quality. Small differences in spectral signatures were revealed between a rural agricultural pond and an urban pond receiving wastewater and landfill run-off; these were limited to the liver and heart, although large differences in body size were apparent, surprisingly with tadpoles from the urban site larger than those from the rural site. Large differences in liver spectra were found between tadpoles from the pesticide and nutrient impacted pond compared to the rural agricultural pond, particularly in regions associated with lipids. Liver mass and hepatosomatic indices were found to be significantly increased in tadpoles from the site impacted by pesticides and trace organic chemicals, suggestive of exposure to environmental contamination. Significant alterations were also found in muscle tissue between tadpoles from these two ponds in regions associated with glycogen, potentially indicative of a stress response. This study highlights the use of IR spectroscopy, a low-cost, rapid and reagent-free technique in the biomonitoring of a class of organisms susceptible to environmental degradation. Copyright © 2016 Elsevier Ltd. All rights reserved.

QUAL-NET, a high temporal-resolution eutrophication model for large hydrographic networks

NASA Astrophysics Data System (ADS)

Minaudo, Camille; Curie, Florence; Jullian, Yann; Gassama, Nathalie; Moatar, Florentina

2018-04-01

To allow climate change impact assessment of water quality in river systems, the scientific community lacks efficient deterministic models able to simulate hydrological and biogeochemical processes in drainage networks at the regional scale, with high temporal resolution and water temperature explicitly determined. The model QUALity-NETwork (QUAL-NET) was developed and tested on the Middle Loire River Corridor, a sub-catchment of the Loire River in France, prone to eutrophication. Hourly variations computed efficiently by the model helped disentangle the complex interactions existing between hydrological and biological processes across different timescales. Phosphorus (P) availability was the most constraining factor for phytoplankton development in the Loire River, but simulating bacterial dynamics in QUAL-NET surprisingly evidenced large amounts of organic matter recycled within the water column through the microbial loop, which delivered significant fluxes of available P and enhanced phytoplankton growth. This explained why severe blooms still occur in the Loire River despite large P input reductions since 1990. QUAL-NET could be used to study past evolutions or predict future trajectories under climate change and land use scenarios.

Descriptive Characteristics of Concussions in National Football League Games, 2010-2011 to 2013-2014.

PubMed

Clark, Michael D; Asken, Breton M; Marshall, Stephen W; Guskiewicz, Kevin M

2017-03-01

Despite a high reported incidence rate of concussion, little is known about the on-field characteristics of injurious head impacts in National Football League (NFL) games. To characterize on-field features (location, player position, and time during game) and biomechanical features (anticipation status, closing distance, impact location and type) associated with concussions in NFL games over a 4-season period (2010-2011 to 2013-2014). Descriptive epidemiology study. We analyzed video of a subset of reported, in-game concussions for the 2010-2011 to 2013-2014 seasons. These videos represented a sample of injuries that were diagnosed and reported on the same day and that could be clearly associated with an in-game collision as captured on video. We determined anticipation status, closing distance, impact location on the injured player's helmet, and impact type (helmet-to-helmet, helmet-to-body, or helmet-to-ground). Associations between these variables were analyzed by use of descriptive statistics and tests of association. A total of 871 diagnosed concussions were reported as occurring during NFL preseason, regular season, and postseason games for the 2010-2011, 2011-2012, 2012-2013, and 2013-2014 seasons. A total of 1324 games were played during this period, giving a concussion incidence rate of 0.658 per game (95% CI, 0.61-0.70). From the video-reviewed subset (n = 429; 49.3%), the majority of injurious impacts occurred with good anticipation (57.3%) and <10 yards of closing distance (59.0%). An association was found between anticipation status and play type ([Formula: see text] = 27.398, P < .001), largely because injuries occurring on pass plays were more likely to be poorly anticipated than injuries during run plays (43.0% vs 21.4%; [Formula: see text] = 14.78, P < .001). Kick returns had the greatest proportion of well-anticipated impacts (78%) and the greatest proportion of impacts with ≥10 yards of closing distance (80%). The type of impact was approximately equally divided between helmet-to-helmet, helmet-to-body, and helmet-to-ground types. The impact location was broadly distributed over the helmet of the injured player. In-game concussions in the NFL occurred through a diverse variety of mechanisms, surprisingly tended to be well-anticipated, and, also surprisingly, occurred with <10 yards of closing distance. The impacts causing concussion were broadly distributed over the helmet. More concussions occurred during the second half of game play, but we do not have evidence to explain this finding.

The Patient Protection and Affordable Care Act: The Impact on Urologic Cancer Care

PubMed Central

Keegan, Kirk A.; Penson, David F.

2012-01-01

In March 2010, the Patient Protection and Affordable Care Act as well as its amendments were signed into law. This sweeping legislation was aimed at controlling spiraling healthcare costs and redressing significant disparities in healthcare access and quality. Cancer diagnoses and their treatments constitute a large component of rising healthcare expenditures and, not surprisingly, the legislation will have a significant influence on cancer care in the United States. Because genitourinary malignancies represent an impressive 25% of all cancer diagnoses per year, this legislation could have a profound impact on urologic oncology. To this end, we will present key components of this landmark legislation, including the proposed expansion to Medicaid coverage, the projected role of Accountable Care Organizations, the expected creation of quality reporting systems, the formation of an independent Patient-Centered Outcomes Research Institute, and enhanced regulation on physician-owned practices. We will specifically address the anticipated effect of these changes on urological cancer care. Briefly, the legal ramifications and current barriers to the statutes will be examined. PMID:22819697

On the dominant impact of vertical moisture gradient on mesoscale cloud cellular organization of stratocumulus

NASA Astrophysics Data System (ADS)

Zhou, X.; Ackerman, A. S.; Fridlind, A. M.; Kollias, P.

2016-12-01

Large-eddy simulations are performed to study the mechanisms of stratocumulus organization. Precipitation tends to increase horizontal cloud scales, but is not required for cloud mesoscale organization. A study of the terms in the prognostic equation for total water mixing ratio variance shows the critical impact of vertical moisture gradient on cloud scale. For precipitating clouds, the organization originates from the negative moisture gradient in the boundary layer resulting from evaporation of precipitation. This hypothesis is supported by simulations in which thermodynamics profiles are nudged to their initial well-mixed state, which reduces cloud scales. Cold pools effect are surprisingly found to respond to rather than determine the cloud mesoscale variability. For non-precipitating clouds, organization results from turbulent transport of moisture variance originating primarily from cloud top, where dry air is entrained into the boundary layer through convection driven by cloud top longwave (LW) cooling. Both LW cooling and a moisture gradient above cloud top are essential for the growth of mesoscale fluctuations.

The many routes to AGN feedback

NASA Astrophysics Data System (ADS)

Morganti, Raffaella

2017-11-01

The energy released by Active Galactic Nuclei (AGN) in the form of radiation, winds or radio plasma jets, is known to impact on the surrounding interstellar medium. The result of these processes, known as AGN (negative) feedback, is suggested to prevent gas, in and around galaxies, from cooling, and to remove, or at least redistribute, gas by driving massive and fast outflows, hence playing a key role in galaxy evolution. Given its importance, a large effort is devoted by the astronomical community to trace the effects of AGN on the surrounding gaseous medium and to quantify their impact for different types of AGN. This review briefly summarizes some of the recent observational results obtained in different wavebands, tracing different phases of the gas. I also summarise new insights they have brought, and the constraints they provide to numerical simulations of galaxy formation and evolution. The recent addition of deep observations of cold gas and, in particular, of cold molecular gas, has brought some interesting surprises and has expanded our understanding of AGN and AGN feedback.

Belowground competition drives invasive plant impact on native species regardless of nitrogen availability.

PubMed

Broadbent, Arthur; Stevens, Carly J; Peltzer, Duane A; Ostle, Nicholas J; Orwin, Kate H

2018-02-01

Plant invasions and eutrophication are pervasive drivers of global change that cause biodiversity loss. Yet, how invasive plant impacts on native species, and the mechanisms underpinning these impacts, vary in relation to increasing nitrogen (N) availability remains unclear. Competition is often invoked as a likely mechanism, but the relative importance of the above and belowground components of this is poorly understood, particularly under differing levels of N availability. To help resolve these issues, we quantified the impact of a globally invasive grass species, Agrostis capillaris, on two co-occurring native New Zealand grasses, and vice versa. We explicitly separated above- and belowground interactions amongst these species experimentally and incorporated an N addition treatment. We found that competition with the invader had large negative impacts on native species growth (biomass decreased by half), resource capture (total N content decreased by up to 75%) and even nutrient stoichiometry (native species tissue C:N ratios increased). Surprisingly, these impacts were driven directly and indirectly by belowground competition, regardless of N availability. Higher root biomass likely enhanced the invasive grass's competitive superiority belowground, indicating that root traits may be useful tools for understanding invasive plant impacts. Our study shows that belowground competition can be more important in driving invasive plant impacts than aboveground competition in both low and high fertility ecosystems, including those experiencing N enrichment due to global change. This can help to improve predictions of how two key drivers of global change, plant species invasions and eutrophication, impact native species diversity.

Laser-induced plasma cloud interaction and ice multiplication under cirrus cloud conditions

PubMed Central

Leisner, Thomas; Duft, Denis; Möhler, Ottmar; Saathoff, Harald; Schnaiter, Martin; Henin, Stefano; Stelmaszczyk, Kamil; Petrarca, Massimo; Delagrange, Raphaëlle; Hao, Zuoqiang; Lüder, Johannes; Petit, Yannick; Rohwetter, Philipp; Kasparian, Jérôme; Wolf, Jean-Pierre; Wöste, Ludger

2013-01-01

Potential impacts of lightning-induced plasma on cloud ice formation and precipitation have been a subject of debate for decades. Here, we report on the interaction of laser-generated plasma channels with water and ice clouds observed in a large cloud simulation chamber. Under the conditions of a typical storm cloud, in which ice and supercooled water coexist, no direct influence of the plasma channels on ice formation or precipitation processes could be detected. Under conditions typical for thin cirrus ice clouds, however, the plasma channels induced a surprisingly strong effect of ice multiplication. Within a few minutes, the laser action led to a strong enhancement of the total ice particle number density in the chamber by up to a factor of 100, even though only a 10−9 fraction of the chamber volume was exposed to the plasma channels. The newly formed ice particles quickly reduced the water vapor pressure to ice saturation, thereby increasing the cloud optical thickness by up to three orders of magnitude. A model relying on the complete vaporization of ice particles in the laser filament and the condensation of the resulting water vapor on plasma ions reproduces our experimental findings. This surprising effect might open new perspectives for remote sensing of water vapor and ice in the upper troposphere. PMID:23733936

Laser-induced plasma cloud interaction and ice multiplication under cirrus cloud conditions.

PubMed

Leisner, Thomas; Duft, Denis; Möhler, Ottmar; Saathoff, Harald; Schnaiter, Martin; Henin, Stefano; Stelmaszczyk, Kamil; Petrarca, Massimo; Delagrange, Raphaëlle; Hao, Zuoqiang; Lüder, Johannes; Petit, Yannick; Rohwetter, Philipp; Kasparian, Jérôme; Wolf, Jean-Pierre; Wöste, Ludger

2013-06-18

Potential impacts of lightning-induced plasma on cloud ice formation and precipitation have been a subject of debate for decades. Here, we report on the interaction of laser-generated plasma channels with water and ice clouds observed in a large cloud simulation chamber. Under the conditions of a typical storm cloud, in which ice and supercooled water coexist, no direct influence of the plasma channels on ice formation or precipitation processes could be detected. Under conditions typical for thin cirrus ice clouds, however, the plasma channels induced a surprisingly strong effect of ice multiplication. Within a few minutes, the laser action led to a strong enhancement of the total ice particle number density in the chamber by up to a factor of 100, even though only a 10(-9) fraction of the chamber volume was exposed to the plasma channels. The newly formed ice particles quickly reduced the water vapor pressure to ice saturation, thereby increasing the cloud optical thickness by up to three orders of magnitude. A model relying on the complete vaporization of ice particles in the laser filament and the condensation of the resulting water vapor on plasma ions reproduces our experimental findings. This surprising effect might open new perspectives for remote sensing of water vapor and ice in the upper troposphere.

Decadal-scale ecosystem memory reveals interactive effects of drought and insect defoliation on boreal forest productivity

NASA Astrophysics Data System (ADS)

Itter, M.; D'Orangeville, L.; Dawson, A.; Kneeshaw, D.; Finley, A. O.

2017-12-01

Drought and insect defoliation have lasting impacts on the dynamics of the boreal forest. Impacts are expected to worsen under global climate change as hotter, drier conditions forecast for much of the boreal increase the frequency and severity of drought and defoliation events. Contemporary ecological theory predicts physiological feedbacks in tree responses to drought and defoliation amplify impacts potentially causing large-scale productivity losses and forest mortality. Quantifying the interactive impacts of drought and insect defoliation on regional forest health is difficult given delayed and persistent responses to disturbance events. We developed a Bayesian hierarchical model to estimate forest growth responses to interactions between drought and insect defoliation by species and size class. Delayed and persistent responses to past drought and defoliation were quantified using empirical memory functions allowing for improved detection of interactions. The model was applied to tree-ring data from stands in Western (Alberta) and Eastern (Québec) regions of the Canadian boreal forest with different species compositions, disturbance regimes, and regional climates. Western stands experience chronic water deficit and forest tent caterpillar (FTC) defoliation; Eastern stands experience irregular water deficit and spruce budworm (SBW) defoliation. Ecosystem memory to past water deficit peaked in the year previous to growth and decayed to zero within 5 (West) to 8 (East) years; memory to past defoliation ranged from 8 (West) to 12 (East) years. The drier regional climate and faster FTC defoliation dynamics (compared to SBW) likely contribute to shorter ecosystem memory in the West. Drought and defoliation had the largest negative impact on large-diameter, host tree growth. Surprisingly, a positive interaction was observed between drought and defoliation for large-diameter, non-host trees likely due to reduced stand-level competition for water. Results highlight the temporal persistence of drought and defoliation stress on boreal forest growth dynamics and provide an empirical estimate of their interactive effects with explicit uncertainty.

Current crowding mediated large contact noise in graphene field-effect transistors

PubMed Central

Karnatak, Paritosh; Sai, T. Phanindra; Goswami, Srijit; Ghatak, Subhamoy; Kaushal, Sanjeev; Ghosh, Arindam

2016-01-01

The impact of the intrinsic time-dependent fluctuations in the electrical resistance at the graphene–metal interface or the contact noise, on the performance of graphene field-effect transistors, can be as adverse as the contact resistance itself, but remains largely unexplored. Here we have investigated the contact noise in graphene field-effect transistors of varying device geometry and contact configuration, with carrier mobility ranging from 5,000 to 80,000 cm2 V−1 s−1. Our phenomenological model for contact noise because of current crowding in purely two-dimensional conductors confirms that the contacts dominate the measured resistance noise in all graphene field-effect transistors in the two-probe or invasive four-probe configurations, and surprisingly, also in nearly noninvasive four-probe (Hall bar) configuration in the high-mobility devices. The microscopic origin of contact noise is directly linked to the fluctuating electrostatic environment of the metal–channel interface, which could be generic to two-dimensional material-based electronic devices. PMID:27929087

History of ball bearings

NASA Technical Reports Server (NTRS)

Dowson, D.; Hamrock, B. J.

1981-01-01

The familiar precision rolling-element bearings of the twentieth century are products of exacting technology and sophisticated science. Their very effectiveness and basic simplicity of form may discourage further interest in their history and development. Yet the full story covers a large portion of recorded history and surprising evidence of an early recognition of the advantages of rolling motion over sliding action and progress toward the development of rolling-element bearings. The development of rolling-element bearings is followed from the earliest civilizations to the end of the eighteenth century. The influence of general technological developments, particularly those concerned with the movement of large building blocks, road transportation, instruments, water-raising equipment, and windmills are discussed, together with the emergence of studies of the nature of rolling friction and the impact of economic factors. By 1800 the essential features of ball and rolling-element bearings had emerged and it only remained for precision manufacture and mass production to confirm the value of these fascinating machine elements.

Current crowding mediated large contact noise in graphene field-effect transistors

NASA Astrophysics Data System (ADS)

Karnatak, Paritosh; Sai, T. Phanindra; Goswami, Srijit; Ghatak, Subhamoy; Kaushal, Sanjeev; Ghosh, Arindam

2016-12-01

The impact of the intrinsic time-dependent fluctuations in the electrical resistance at the graphene-metal interface or the contact noise, on the performance of graphene field-effect transistors, can be as adverse as the contact resistance itself, but remains largely unexplored. Here we have investigated the contact noise in graphene field-effect transistors of varying device geometry and contact configuration, with carrier mobility ranging from 5,000 to 80,000 cm2 V-1 s-1. Our phenomenological model for contact noise because of current crowding in purely two-dimensional conductors confirms that the contacts dominate the measured resistance noise in all graphene field-effect transistors in the two-probe or invasive four-probe configurations, and surprisingly, also in nearly noninvasive four-probe (Hall bar) configuration in the high-mobility devices. The microscopic origin of contact noise is directly linked to the fluctuating electrostatic environment of the metal-channel interface, which could be generic to two-dimensional material-based electronic devices.

Untapped potential of health impact assessment.

PubMed

Winkler, Mirko S; Krieger, Gary R; Divall, Mark J; Cissé, Guéladio; Wielga, Mark; Singer, Burton H; Tanner, Marcel; Utzinger, Jürg

2013-04-01

The World Health Organization has promoted health impact assessment (HIA) for over 20 years. At the 2012 United Nations Conference on Sustainable Development (Rio+20), HIA was discussed as a critical method for linking health to "green economy" and "institutional framework" strategies for sustainable development. In countries having a high human development index (HDI), HIA has been added to the overall assessment suite that typically includes potential environmental and social impacts, but it is rarely required as part of the environmental and social impact assessment for large development projects. When they are performed, project-driven HIAs are governed by a combination of project proponent and multilateral lender performance standards rather than host country requirements. Not surprisingly, in low-HDI countries HIA is missing from the programme and policy arena in the absence of an external project driver. Major drivers of global change (e.g. population growth and urbanization, growing pressure on natural resources and climate change) inordinately affect low- and medium-HDI countries; however, in such countries HIA is conspicuously absent. If the cloak of HIA invisibility is to be removed, it must be shown that HIA is useful and beneficial and, hence, an essential component of the 21st century's sustainable development agenda. We analyse where and how HIA can become fully integrated into the impact assessment suite and argue that the impact of HIA must not remain obscure.

Untapped potential of health impact assessment

PubMed Central

Krieger, Gary R; Divall, Mark J; Cissé, Guéladio; Wielga, Mark; Singer, Burton H; Tanner, Marcel; Utzinger, Jürg

2013-01-01

Abstract The World Health Organization has promoted health impact assessment (HIA) for over 20 years. At the 2012 United Nations Conference on Sustainable Development (Rio+20), HIA was discussed as a critical method for linking health to “green economy” and “institutional framework” strategies for sustainable development. In countries having a high human development index (HDI), HIA has been added to the overall assessment suite that typically includes potential environmental and social impacts, but it is rarely required as part of the environmental and social impact assessment for large development projects. When they are performed, project-driven HIAs are governed by a combination of project proponent and multilateral lender performance standards rather than host country requirements. Not surprisingly, in low-HDI countries HIA is missing from the programme and policy arena in the absence of an external project driver. Major drivers of global change (e.g. population growth and urbanization, growing pressure on natural resources and climate change) inordinately affect low- and medium-HDI countries; however, in such countries HIA is conspicuously absent. If the cloak of HIA invisibility is to be removed, it must be shown that HIA is useful and beneficial and, hence, an essential component of the 21st century’s sustainable development agenda. We analyse where and how HIA can become fully integrated into the impact assessment suite and argue that the impact of HIA must not remain obscure. PMID:23599554

Korotkoff Sounds - The Improbable also Occurs

PubMed Central

Estañol, Bruno; Delgado, Guillermo; Borgstein, Johannes

2013-01-01

Very few discoveries have had such a large impact on and relevance to clinical medicine as the noninvasive measurement of the diastolic blood pressure. A number of gifted physiologists and clinicians were ineffectively in search of a noninvasive method to determine the diastolic pressure. Nonetheless, the quantification of the diastolic BP was not achieved by any of these clinical or physiological researchers, but by an unlikely and unexpected figure: Nikolai Sergeevich Korotkoff (1874-1920), a young Russian army surgeon, working under precarious conditions in the hardship of diverse wars. It is easy to dismiss the achievement of Korotkoff as a serendipitous discovery, similar to that of Alexander Fleming in the discovery of penicillin. However, Nassim N. Taleb's recent black swan theory may serve to illustrate his discovery in a new and, perhaps, surprising way. PMID:24343557

Neutron Spectroscopy Can Constrain the Composition and Provenance of Phobos and Deimos

NASA Technical Reports Server (NTRS)

Elphic, R. C.; Lee, P.; Zolensky, M. E.; Mittelfehldt, D. W.; Lim, L.; Colaprete, A.

2016-01-01

The origin of the martian moons Phobos and Deimos is obscure and enigmatic. Hypotheses include the capture of asteroids originally from the outer main belt or beyond, residual material left over from Mars' formation, and accreted ejecta from a large impact on Mars, among others. Measurements of reflectance spectra indicate a similarity to dark, red D-type asteroids, but could indicate a highly space-weathered veneer. Here we suggest a way of constraining the near-surface composition of the two moons, for comparison to known meteoritic compositions. Neutron spectroscopy, particularly the thermal and epithermal neutron flux, distinguishes clearly between various classes of meteorites and varying hydrogen (water) abundances. Perhaps most surprising of all, a rendezvous with Phobos or Deimos is not necessary to achieve this.

Neutron Spectroscopy Can Constrain the Composition and Provenance of Phobos and Deimos

NASA Technical Reports Server (NTRS)

Elphic, R. C.; Lee, P.; Zolensky, M. E.; Mittlefehldt, D. W.; Lim, L. F.; Colaprete, A.

2016-01-01

The origin of the martian moons Phobos and Deimos is obscure and enigmatic. Hypotheses include the capture of small bodies originally from the outer main belt or beyond, residual material left over from Mars' formation, and accreted ejecta from a large impact on Mars, among others. Measurements of reflectance spectra indicate a similarity to low-albedo, red D-type asteroids, but could indicate a highly space-weathered veneer. Here we suggest a way of constraining the near-surface composition of the two moons, for comparison with known meteoritic compositions. Neutron spectroscopy, particularly the thermal and epithermal neutron flux, distinguishes clearly between various classes of meteorites and varying hydrogen (water) abundances. Perhaps most surprising of all, a rendezvous with Phobos or Deimos is not necessary to achieve this. Multiple flybys suffice.

The origins of intensive marine fishing in medieval Europe: the English evidence.

PubMed

Barrett, James H; Locker, Alison M; Roberts, Callum M

2004-12-07

The catastrophic impact of fishing pressure on species such as cod and herring is well documented. However, the antiquity of their intensive exploitation has not been established. Systematic catch statistics are only available for ca.100 years, but large-scale fishing industries existed in medieval Europe and the expansion of cod fishing from the fourteenth century (first in Iceland, then in Newfoundland) played an important role in the European colonization of the Northwest Atlantic. History has demonstrated the scale of these late medieval and post-medieval fisheries, but only archaeology can illuminate earlier practices. Zooarchaeological evidence shows that the clearest changes in marine fishing in England between AD 600 and 1600 occurred rapidly around AD 1000 and involved large increases in catches of herring and cod. Surprisingly, this revolution predated the documented post-medieval expansion of England's sea fisheries and coincided with the Medieval Warm Period--when natural herring and cod productivity was probably low in the North Sea. This counterintuitive discovery can be explained by the concurrent rise of urbanism and human impacts on freshwater ecosystems. The search for 'pristine' baselines regarding marine ecosystems will thus need to employ medieval palaeoecological proxies in addition to recent fisheries data and early modern historical records.

The origins of intensive marine fishing in medieval Europe: the English evidence.

PubMed Central

Barrett, James H.; Locker, Alison M.; Roberts, Callum M.

2004-01-01

The catastrophic impact of fishing pressure on species such as cod and herring is well documented. However, the antiquity of their intensive exploitation has not been established. Systematic catch statistics are only available for ca.100 years, but large-scale fishing industries existed in medieval Europe and the expansion of cod fishing from the fourteenth century (first in Iceland, then in Newfoundland) played an important role in the European colonization of the Northwest Atlantic. History has demonstrated the scale of these late medieval and post-medieval fisheries, but only archaeology can illuminate earlier practices. Zooarchaeological evidence shows that the clearest changes in marine fishing in England between AD 600 and 1600 occurred rapidly around AD 1000 and involved large increases in catches of herring and cod. Surprisingly, this revolution predated the documented post-medieval expansion of England's sea fisheries and coincided with the Medieval Warm Period--when natural herring and cod productivity was probably low in the North Sea. This counterintuitive discovery can be explained by the concurrent rise of urbanism and human impacts on freshwater ecosystems. The search for 'pristine' baselines regarding marine ecosystems will thus need to employ medieval palaeoecological proxies in addition to recent fisheries data and early modern historical records. PMID:15590590

Optimized static and video EEG rapid serial visual presentation (RSVP) paradigm based on motion surprise computation

NASA Astrophysics Data System (ADS)

Khosla, Deepak; Huber, David J.; Bhattacharyya, Rajan

2017-05-01

In this paper, we describe an algorithm and system for optimizing search and detection performance for "items of interest" (IOI) in large-sized images and videos that employ the Rapid Serial Visual Presentation (RSVP) based EEG paradigm and surprise algorithms that incorporate motion processing to determine whether static or video RSVP is used. The system works by first computing a motion surprise map on image sub-regions (chips) of incoming sensor video data and then uses those surprise maps to label the chips as either "static" or "moving". This information tells the system whether to use a static or video RSVP presentation and decoding algorithm in order to optimize EEG based detection of IOI in each chip. Using this method, we are able to demonstrate classification of a series of image regions from video with an azimuth value of 1, indicating perfect classification, over a range of display frequencies and video speeds.

Teasing apart coercion and surprisal: Evidence from eye-movements and ERPs.

PubMed

Delogu, Francesca; Crocker, Matthew W; Drenhaus, Heiner

2017-04-01

Previous behavioral and electrophysiological studies have presented evidence suggesting that coercion expressions (e.g., began the book) are more difficult to process than control expressions like read the book. While this processing cost has been attributed to a specific coercion operation for recovering an event-sense of the complement (e.g., began reading the book), an alternative view based on the Surprisal Theory of language processing would attribute the cost to the relative unpredictability of the complement noun in the coercion compared to the control condition, with no need to postulate coercion-specific mechanisms. In two experiments, monitoring eye-tracking and event-related potentials (ERPs), respectively, we sought to determine whether there is any evidence for coercion-specific processing cost above-and-beyond the difficulty predicted by surprisal, by contrasting coercing and control expressions with a further control condition in which the predictability of the complement noun was similar to that in the coercion condition (e.g., bought the book). While the eye-tracking study showed significant effects of surprisal and a marginal effect of coercion on late reading measures, the ERP study clearly supported the surprisal account. Overall, our findings suggest that the coercion cost largely reflects the surprisal of the complement noun with coercion specific operations possibly influencing later processing stages. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Sense of agency, associative learning, and schizotypy

PubMed Central

Moore, James W.; Dickinson, Anthony; Fletcher, Paul C.

2011-01-01

Despite the fact that the role of learning is recognised in empirical and theoretical work on sense of agency (SoA), the nature of this learning has, rather surprisingly, received little attention. In the present study we consider the contribution of associative mechanisms to SoA. SoA can be measured quantitatively as a temporal linkage between voluntary actions and their external effects. Using an outcome blocking procedure, it was shown that training action–outcome associations under conditions of increased surprise augmented this temporal linkage. Moreover, these effects of surprise were correlated with schizotypy scores, suggesting that individual differences in higher level experiences are related to associative learning and to its impact on SoA. These results are discussed in terms of models of SoA, and our understanding of disrupted SoA in certain disorders. PMID:21295497

Properties of styrene-maleic anhydride copolymers containing wood-based fillers

Treesearch

John Simonsen; Rodney Jacobson; Roger Rowell

1998-01-01

Recycled newsprint (ONP) and dry process aspen fiber were combined with styrene maleic anhydride (SMA) copolymers containing either 7 or 14 percent maleic anhydride. The fiber-filled SMA composites were equivalent or superior to unfilled SMA in strength, stiffness, and notched Izod impact strength. ONP performed surprisingly well as a filler. Unnotched Izod impact...

Experimental evidence that livestock grazing intensity affects the activity of a generalist predator

NASA Astrophysics Data System (ADS)

Villar, Nacho; Lambin, Xavier; Evans, Darren; Pakeman, Robin; Redpath, Steve

2013-05-01

Grazing by domestic ungulates has substantial impacts on ecosystem structure and composition. In grasslands of the northern hemisphere, livestock grazing limits populations of small mammals, which are a main food source for a variety of vertebrate predators. However, no experimental studies have described the impact of livestock grazing on vertebrate predators. We experimentally manipulated sheep and cattle grazing intensity in the Scottish uplands to test its impact on a relatively abundant small mammal, the field vole (Microtus agrestis), and its archetypal generalist predator, the red fox (Vulpes vulpes). We demonstrate that ungulate grazing had a strong consistent negative impact on both vole densities and indices of fox activity. Ungulate grazing did not substantially affect the relationship between fox activity and vole densities. However, the data suggested that, as grazing intensity increased i) fox activity indices tended to be higher when vole densities were low, and ii) the relationship between fox activity and vole density was weaker. All these patterns are surprising given the relative small scale of our experiment compared to large red fox territories in upland habitats of Britain, and suggest that domestic grazing intensity causes a strong response in the activity of generalist predators important for their conservation in grassland ecosystems.

Unexpected Nongenetic Individual Heterogeneity and Trait Covariance in Daphnia and Its Consequences for Ecological and Evolutionary Dynamics.

PubMed

Cressler, Clayton E; Bengtson, Stefan; Nelson, William A

2017-07-01

Individual differences in genetics, age, or environment can cause tremendous differences in individual life-history traits. This individual heterogeneity generates demographic heterogeneity at the population level, which is predicted to have a strong impact on both ecological and evolutionary dynamics. However, we know surprisingly little about the sources of individual heterogeneity for particular taxa or how different sources scale up to impact ecological and evolutionary dynamics. Here we experimentally study the individual heterogeneity that emerges from both genetic and nongenetic sources in a species of freshwater zooplankton across a large gradient of food quality. Despite the tight control of environment, we still find that the variation from nongenetic sources is greater than that from genetic sources over a wide range of food quality and that this variation has strong positive covariance between growth and reproduction. We evaluate the general consequences of genetic and nongenetic covariance for ecological and evolutionary dynamics theoretically and find that increasing nongenetic variation slows evolution independent of the correlation in heritable life-history traits but that the impact on ecological dynamics depends on both nongenetic and genetic covariance. Our results demonstrate that variation in the relative magnitude of nongenetic versus genetic sources of variation impacts the predicted ecological and evolutionary dynamics.

Queen Quality and the Impact of Honey Bee Diseases on Queen Health: Potential for Interactions between Two Major Threats to Colony Health

PubMed Central

Amiri, Esmaeil; Strand, Micheline K.; Rueppell, Olav; Tarpy, David R.

2017-01-01

Western honey bees, Apis mellifera, live in highly eusocial colonies that are each typically headed by a single queen. The queen is the sole reproductive female in a healthy colony, and because long-term colony survival depends on her ability to produce a large number of offspring, queen health is essential for colony success. Honey bees have recently been experiencing considerable declines in colony health. Among a number of biotic and abiotic factors known to impact colony health, disease and queen failure are repeatedly reported as important factors underlying colony losses. Surprisingly, there are relatively few studies on the relationship and interaction between honey bee diseases and queen quality. It is critical to understand the negative impacts of pests and pathogens on queen health, how queen problems might enable disease, and how both factors influence colony health. Here, we review the current literature on queen reproductive potential and the impacts of honey bee parasites and pathogens on queens. We conclude by highlighting gaps in our knowledge on the combination of disease and queen failure to provide a perspective and prioritize further research to mitigate disease, improve queen quality, and ensure colony health. PMID:28481294

FamilyPso - a new questionnaire to assess the impact of psoriasis on partners and family of patients.

PubMed

Mrowietz, U; Hartmann, A; Weißmann, W; Zschocke, I

2017-01-01

Psoriasis is a lifelong disease for which there is no cure. It has been conclusively shown across all ethnicities that patients suffering from psoriasis have a significantly reduced health-related quality of life and a high disease burden. Surprisingly little is known about the impact of a patient's psoriasis on partners or family members. To address this issue a systematic literature search has been conducted and interviews with relatives of psoriasis patients living in the same household were performed. From this collected information, items were generated that were commonly mentioned to affect living and tested in a large group of relatives before the final item selection was done. A first set of 29 items was selected and tested in a study with 96 patient relatives. After adjustment and statistical analysis, the final FamilyPso questionnaire was condensed to 15 items to assess the burden of partners or family members living together with psoriasis patients. The FamilyPso enables physicians to achieve a better understanding of the impact of psoriasis as a lifelong chronic disease on partners and the family environment. © 2016 European Academy of Dermatology and Venereology.

Student Perceptions of General Education Requirements at a Large Public University: No Surprises?

ERIC Educational Resources Information Center

Thompson, Clarissa A.; Eodice, Michele; Tran, Phuoc

2015-01-01

The current study surveyed students' knowledge of and perceptions about general education requirements at a large research-intensive university. Findings revealed that students harbored misconceptions about general education requirements and illuminated the reasons why students were choosing to take required general education courses at other…

Separate neural representations of prediction error valence and surprise: Evidence from an fMRI meta-analysis.

PubMed

Fouragnan, Elsa; Retzler, Chris; Philiastides, Marios G

2018-03-25

Learning occurs when an outcome differs from expectations, generating a reward prediction error signal (RPE). The RPE signal has been hypothesized to simultaneously embody the valence of an outcome (better or worse than expected) and its surprise (how far from expectations). Nonetheless, growing evidence suggests that separate representations of the two RPE components exist in the human brain. Meta-analyses provide an opportunity to test this hypothesis and directly probe the extent to which the valence and surprise of the error signal are encoded in separate or overlapping networks. We carried out several meta-analyses on a large set of fMRI studies investigating the neural basis of RPE, locked at decision outcome. We identified two valence learning systems by pooling studies searching for differential neural activity in response to categorical positive-versus-negative outcomes. The first valence network (negative > positive) involved areas regulating alertness and switching behaviours such as the midcingulate cortex, the thalamus and the dorsolateral prefrontal cortex whereas the second valence network (positive > negative) encompassed regions of the human reward circuitry such as the ventral striatum and the ventromedial prefrontal cortex. We also found evidence of a largely distinct surprise-encoding network including the anterior cingulate cortex, anterior insula and dorsal striatum. Together with recent animal and electrophysiological evidence this meta-analysis points to a sequential and distributed encoding of different components of the RPE signal, with potentially distinct functional roles. © 2018 Wiley Periodicals, Inc.

Dyslexia and Learning Disabilities in Canada and the UK: The Impact of Its Disability Employment Laws

ERIC Educational Resources Information Center

Gerber, Paul J.; Batalo, Cecilia G.; Achola, Edwin O.

2012-01-01

The impact of employment laws pertaining to individuals with learning disabilities in Canada and dyslexia in the UK were investigated via the extant research literature. Currently, there is very little research in this area despite Canada and the UK having laws in effect for decades. Surprisingly, their laws have been revamped despite an absence…

Newark Kids Count 2009: A City Profile of Child Well-Being

ERIC Educational Resources Information Center

Association for Children of New Jersey, 2009

2009-01-01

The 2009 Newark Kids Count Report provides the first data on how the economic downturn in New Jersey and the nation is impacting the lives of children and families in Newark. It is no surprise that child poverty is on the rise again, after several years of progress in reducing the child poverty rate. Rising unemployment has impacted Newark…

The Impact of E-Mail Address on Credibility in Higher Education

ERIC Educational Resources Information Center

Livermore, Jeffrey A.; Scafe, Marla G.; Asher, Corinne

2016-01-01

The researchers have often been surprised to see the e-mail addresses used by our students and colleagues. Many students and faculty choose their own user names and choose their providers. E-mail addresses may provide an insight into the background and employment situation of the user. This study quantifies the impact that e-mail address choices…

The impact of Hurricane Sandy on the shoreface and inner shelf of Fire Island, New York: large bedform migration but limited erosion

USGS Publications Warehouse

Goff, John A.; Flood, Roger D.; Austin, James A.; Schwab, William C.; Christensen, Beth A.; Browne, Cassandra M.; Denny, Jane F.; Baldwin, Wayne E.

2015-01-01

We investigate the impact of superstorm Sandy on the lower shoreface and inner shelf offshore the barrier island system of Fire Island, NY using before-and-after surveys involving swath bathymetry, backscatter and CHIRP acoustic reflection data. As sea level rises over the long term, the shoreface and inner shelf are eroded as barrier islands migrate landward; large storms like Sandy are thought to be a primary driver of this largely evolutionary process. The “before” data were collected in 2011 by the U.S. Geological Survey as part of a long-term investigation of the Fire Island barrier system. The “after” data were collected in January, 2013, ~two months after the storm. Surprisingly, no widespread erosional event was observed. Rather, the primary impact of Sandy on the shoreface and inner shelf was to force migration of major bedforms (sand ridges and sorted bedforms) 10’s of meters WSW alongshore, decreasing in migration distance with increasing water depth. Although greater in rate, this migratory behavior is no different than observations made over the 15-year span prior to the 2011 survey. Stratigraphic observations of buried, offshore-thinning fluvial channels indicate that long-term erosion of older sediments is focused in water depths ranging from the base of the shoreface (~13–16 m) to ~21 m on the inner shelf, which is coincident with the range of depth over which sand ridges and sorted bedforms migrated in response to Sandy. We hypothesize that bedform migration regulates erosion over these water depths and controls the formation of a widely observed transgressive ravinement; focusing erosion of older material occurs at the base of the stoss (upcurrent) flank of the bedforms. Secondary storm impacts include the formation of ephemeral hummocky bedforms and the deposition of a mud event layer.

A Numeric Scorecard Assessing the Mental Health Preparedness for Large-Scale Crises at College and University Campuses: A Delphi Study

ERIC Educational Resources Information Center

Burgin, Rick A.

2012-01-01

Large-scale crises continue to surprise, overwhelm, and shatter college and university campuses. While the devastation to physical plants and persons is often evident and is addressed with crisis management plans, the number of emotional casualties left in the wake of these large-scale crises may not be apparent and are often not addressed with…

Constraining explosive volcanism: subjective choices during estimates of eruption magnitude

USGS Publications Warehouse

Klawonn, Malin; Houghton, Bruce F.; Swanson, Don; Fagents, Sarah A.; Wessel, Paul; Wolfe, Cecily J.

2014-01-01

When estimating the magnitude of explosive eruptions from their deposits, individuals make three sets of critical choices with respect to input data: the spacing of sampling sites, the selection of contour intervals to constrain the field measurements, and the hand contouring of thickness/isomass data, respectively. Volcanologists make subjective calls, as there are no accepted published protocols and few accounts of how these choices will impact estimates of eruption magnitude. Here, for the first time, we took a set of unpublished thickness measurements from the 1959 Kīlauea Iki pyroclastic fall deposit and asked 101 volcanologists worldwide to hand contour the data. First, there were surprisingly consistent volume estimates across maps with three different sampling densities. Second, the variability in volume calculations imparted by individuals’ choices of contours is also surprisingly low and lies between s = 5 and 8 %. Third, volume estimation is insensitive to the extent to which different individuals “smooth” the raw data in constructing contour lines. Finally, large uncertainty is associated with the construction of the thinnest isopachs, which is likely to underestimate the actual trend of deposit thinning. The net result is that researchers can have considerable confidence in using volume or dispersal data from multiple authors and different deposits for comparative studies. These insights should help volcanologists around the world to optimize design and execution of field-based studies to characterize accurately the volume of pyroclastic deposits.

Constraining explosive volcanism: subjective choices during estimates of eruption magnitude

NASA Astrophysics Data System (ADS)

Klawonn, Malin; Houghton, Bruce F.; Swanson, Donald A.; Fagents, Sarah A.; Wessel, Paul; Wolfe, Cecily J.

2014-02-01

When estimating the magnitude of explosive eruptions from their deposits, individuals make three sets of critical choices with respect to input data: the spacing of sampling sites, the selection of contour intervals to constrain the field measurements, and the hand contouring of thickness/isomass data, respectively. Volcanologists make subjective calls, as there are no accepted published protocols and few accounts of how these choices will impact estimates of eruption magnitude. Here, for the first time, we took a set of unpublished thickness measurements from the 1959 Kīlauea Iki pyroclastic fall deposit and asked 101 volcanologists worldwide to hand contour the data. First, there were surprisingly consistent volume estimates across maps with three different sampling densities. Second, the variability in volume calculations imparted by individuals' choices of contours is also surprisingly low and lies between s = 5 and 8 %. Third, volume estimation is insensitive to the extent to which different individuals "smooth" the raw data in constructing contour lines. Finally, large uncertainty is associated with the construction of the thinnest isopachs, which is likely to underestimate the actual trend of deposit thinning. The net result is that researchers can have considerable confidence in using volume or dispersal data from multiple authors and different deposits for comparative studies. These insights should help volcanologists around the world to optimize design and execution of field-based studies to characterize accurately the volume of pyroclastic deposits.

Linguistics at School: Language Awareness in Primary and Secondary Education

ERIC Educational Resources Information Center

Denham, Kristin, Ed.; Lobeck, Anne, Ed.

2010-01-01

Linguistics is a subject that has remained largely confined to the academy, rather than being integrated into school curricula. This is unfortunate but not surprising, as although some teacher education programs include courses on linguistics, it is not comprehensively integrated into teacher education, so it is largely absent from the curriculum.…

The Patient Protection and Affordable Care Act: the impact on urologic cancer care.

PubMed

Keegan, Kirk A; Penson, David F

2013-10-01

In March 2010, the Patient Protection and Affordable Care Act as well as its amendments were signed into law. This sweeping legislation was aimed at controlling spiraling healthcare costs and redressing significant disparities in healthcare access and quality. Cancer diagnoses and their treatments constitute a large component of rising healthcare expenditures and, not surprisingly, the legislation will have a significant influence on cancer care in the USA. Because genitourinary malignancies represent an impressive 25% of all cancer diagnoses per year, this legislation could have a profound impact on urologic oncology. To this end, we will present key components of this landmark legislation, including the proposed expansion to Medicaid coverage, the projected role of Accountable Care Organizations, the expected creation of quality reporting systems, the formation of an independent Patient-Centered Outcomes Research Institute, and enhanced regulation on physician-owned practices. We will specifically address the anticipated effect of these changes on urologic cancer care. Briefly, the legal ramifications and current barriers to the statutes will be examined. Published by Elsevier Inc.

Looking at Leadership: Some Neglected Issues

DTIC Science & Technology

1977-10-01

problems. (3) Use of power Using social skills, rewards and punishments to control organizational events. A way to study leaders is to simulate the...conditions managers face. Simulation paradigms allow detailed ex- amination of the complex forces impacting on organizations from without and within...modifying the impacts of other variables. Given this horrendous complexity, it is no surprise that Vaill (in press) has questioned whether it makes much

The parallel universe of RNA folding.

PubMed

Batey, R T; Doudna, J A

1998-05-01

How do large RNA molecules find their active conformations among a universe of possible structures? Two recent studies reveal that RNA folding is a rapid and ordered process, with surprising similarities to protein folding mechanisms.

Comprehensive Sexuality Education as a Primary Prevention Strategy for Sexual Violence Perpetration.

PubMed

Schneider, Madeline; Hirsch, Jennifer S

2018-01-01

Sexual violence (SV) represents a serious public health problem with high rates and numerous health consequences. Current primary prevention strategies to reduce SV perpetration have been shown to be largely ineffective-not surprisingly, since as others have pointed out current prevention largely fails to draw on existing knowledge about the characteristics of effective prevention. In this article, we examine the potential of K-12 comprehensive sexuality education (CSE), guided by the National Sexuality Education Standards (NSES), to be an effective strategy. Our discussion uses socioecological and feminist theories as a guide, examines the extent to which NSES-guided CSE could both meet the qualities of effective prevention programs and mitigate the risk factors that are most implicated in perpetration behavior, and considers the potential limitations of this approach. We suggest that sequential, K-12 program has potential to prevent the emergence of risk factors associated with SV perpetration by starting prevention early on in the life course. CSE has not yet been evaluated with SV perpetration behavior as an outcome, and this article synthesizes what is known about drivers of SV perpetration and the potential impacts of CSE to argue for the importance of future research in this area. The primary recommendation is for longitudinal research to examine the impact of CSE on SV perpetration as well as on other sexual and reproductive health outcomes.

Solar magnetic fields

NASA Astrophysics Data System (ADS)

Hood, Alan W.; Hughes, David W.

2011-08-01

This review provides an introduction to the generation and evolution of the Sun's magnetic field, summarising both observational evidence and theoretical models. The eleven year solar cycle, which is well known from a variety of observed quantities, strongly supports the idea of a large-scale solar dynamo. Current theoretical ideas on the location and mechanism of this dynamo are presented. The solar cycle influences the behaviour of the global coronal magnetic field and it is the eruptions of this field that can impact on the Earth's environment. These global coronal variations can be modelled to a surprising degree of accuracy. Recent high resolution observations of the Sun's magnetic field in quiet regions, away from sunspots, show that there is a continual evolution of a small-scale magnetic field, presumably produced by small-scale dynamo action in the solar interior. Sunspots, a natural consequence of the large-scale dynamo, emerge, evolve and disperse over a period of several days. Numerical simulations can help to determine the physical processes governing the emergence of sunspots. We discuss the interaction of these emerging fields with the pre-existing coronal field, resulting in a variety of dynamic phenomena.

The roles of large top predators in coastal ecosystems: new insights from long term ecological research

USGS Publications Warehouse

Rosenblatt, Adam E.; Heithaus, Michael R.; Mather, Martha E.; Matich, Philip; Nifong, James C.; Ripple, William J.; Silliman, Brian R.

2013-01-01

During recent human history, human activities such as overhunting and habitat destruction have severely impacted many large top predator populations around the world. Studies from a variety of ecosystems show that loss or diminishment of top predator populations can have serious consequences for population and community dynamics and ecosystem stability. However, there are relatively few studies of the roles of large top predators in coastal ecosystems, so that we do not yet completely understand what could happen to coastal areas if large top predators are extirpated or significantly reduced in number. This lack of knowledge is surprising given that coastal areas around the globe are highly valued and densely populated by humans, and thus coastal large top predator populations frequently come into conflict with coastal human populations. This paper reviews what is known about the ecological roles of large top predators in coastal systems and presents a synthesis of recent work from three coastal eastern US Long Term Ecological Research (LTER) sites where long-term studies reveal what appear to be common themes relating to the roles of large top predators in coastal systems. We discuss three specific themes: (1) large top predators acting as mobile links between disparate habitats, (2) large top predators potentially affecting nutrient and biogeochemical dynamics through localized behaviors, and (3) individual specialization of large top predator behaviors. We also discuss how research within the LTER network has led to enhanced understanding of the ecological roles of coastal large top predators. Highlighting this work is intended to encourage further investigation of the roles of large top predators across diverse coastal aquatic habitats and to better inform researchers and ecosystem managers about the importance of large top predators for coastal ecosystem health and stability.

Developing the greatest Blue Economy: Water productivity, fresh water depletion, and virtual water trade in the Great Lakes basin

NASA Astrophysics Data System (ADS)

Mayer, A. S.; Ruddell, B. L.; Mubako, S. T.

2016-12-01

The Great Lakes basin hosts the world's most abundant surface fresh water reserve. Historically an industrial and natural resource powerhouse, the region has suffered economic stagnation in recent decades. Meanwhile, growing water resource scarcity around the world is creating pressure on water-intensive human activities. This situation creates the potential for the Great Lakes region to sustainably utilize its relative water wealth for economic benefit. We combine economic production and trade datasets with water consumption data and models of surface water depletion in the region. We find that, on average, the current economy does not create significant impacts on surface waters, but there is some risk that unregulated large water uses can create environmental flow impacts if they are developed in the wrong locations. Water uses drawing on deep groundwater or the Great Lakes themselves are unlikely to create a significant depletion, and discharge of groundwater withdrawals to surface waters offsets most surface water depletion. This relative abundance of surface water means that science-based management of large water uses to avoid accidentally creating "hotspots" is likely to be successful in avoiding future impacts, even if water use is significantly increased. Commercial water uses are the most productive, with thermoelectric, mining, and agricultural water uses in the lowest tier of water productivity. Surprisingly for such a water-abundant economy, the region is a net importer of water-derived goods and services. This, combined with the abundance of surface water, suggests that the region's water-based economy has room to grow in the 21st century.

Observational evidence for volcanic impact on sea level and the global water cycle.

PubMed

Grinsted, A; Moore, J C; Jevrejeva, S

2007-12-11

It has previously been noted that there are drops in global sea level (GSL) after some major volcanic eruptions. However, observational evidence has not been convincing because there is substantial variability in the global sea level record over periods similar to those at which we expect volcanoes to have an impact. To quantify the impact of volcanic eruptions we average monthly GSL data from 830 tide gauge records around five major volcanic eruptions. Surprisingly, we find that the initial response to a volcanic eruption is a significant rise in sea level of 9 +/- 3 mm in the first year after the eruption. This rise is followed by a drop of 7 +/- 3 mm in the period 2-3 years after the eruption relative to preeruption sea level. These results are statistically robust and no particular volcanic eruption or ocean region dominates the signature we find. Neither the drop nor especially the rise in GSL can be explained by models of lower oceanic heat content. We suggest that the mechanism is a transient disturbance of the water cycle with a delayed response of land river runoff relative to ocean evaporation and global precipitation that affects global sea level. The volcanic impact on the water cycle and sea levels is comparable in magnitude to that of a large El Niño-La Niña cycle, amounting to approximately 5% of global land precipitation.

Wave reflection effects in the central circulation of American alligators (Alligator mississippiensis): what the heart sees.

PubMed

Syme, Douglas A; Gamperl, A Kurt; Braun, Marvin H; Jones, David R

2006-10-01

A large central compliance is thought to dominate the hemodynamics of all vertebrates except birds and mammals. Yet large crocodilians may adumbrate the avian and mammalian condition and set the stage for significant wave transmission (reflection) effects, with potentially detrimental impacts on cardiac performance. To investigate whether crocodilians exhibit wave reflection effects, pressures and flows were recorded from the right aorta, carotid artery, and femoral artery of six adult, anesthetized American alligators (Alligator mississippiensis) during control conditions and after experimentally induced vasodilation and constriction. Hallmarks of wave reflection phenomena were observed, including marked differences between the measured profiles for flow and pressure, peaking of the femoral pressure pulse, and a diastolic wave in the right aortic pressure profile. Pulse wave velocity and peripheral input impedance increased with progressive constriction, and thus changes in both the timing and magnitude of reflections accounted for the altered reflection effects. Resolution of pressure and flow waves into incident and reflected components showed substantial reflection effects within the right aorta, with reflection coefficients at the first harmonic approaching 0.3 when constricted. Material properties measured from isolated segments of blood vessels revealed a major reflection site at the periphery and, surprisingly, at the junction of the truncus and right aorta. Thus, while our results clearly show that significant wave reflection phenomena are not restricted to birds and mammals, they also suggest that rather than cope with potential negative impacts of reflections, the crocodilian heart simply avoids them because of a large impedance mismatch at the truncus.

Striations, Polish, and Related Features from Clasts in Impact-Ejecta Deposits and the "Tillite Problem"

NASA Technical Reports Server (NTRS)

Rampino, M. R.; Ernstson, K.; Anguita, F.; Claudin F.

1997-01-01

Proximal ejecta deposits related to three large terrestrial impacts, the 14.8-Ma Ries impact structure in Germany (the Bunte Breccia), the 65-Ma Chicxulub impact structure in the Yucatan (the Albion and Pook's Hill Diamictites in Belize) and the mid-Tertiary Azuara impact structure in Spain (the Pelarda Fm.) occur in the form of widespread debris-flow deposits most likely originating from ballistic processes. These impact-related diamictites typically are poorly sorted, containing grain sizes from clay to large boulders and blocks, and commonly display evidence of mass flow, including preferred orientation of long axes of clasts, class imbrication, flow noses, plugs and pods of coarse debris, and internal shear planes. Clasts of various lithologies show faceting, various degrees of rounding, striations (including nailhead striae), crescentic chattermarks, mirror-like polish, percussion marks, pitting, and penetration features. Considering the impact history of the Earth, it is surprising that so few ballistic ejecta, deposits have been discovered, unless the preservation potential is extremely low, or such materials exist but have been overlooked or misidentified as other types of geologic deposits . Debris-flow diamictites of various kinds have been reported in the geologic record, but these are commonly attributed to glaciation based on the coarse and poorly sorted nature of the deposits and, in many cases, on the presence of clasts showing features considered diagnostic of glacial action, including striations of various kinds, polish, and pitting. These diamictites are the primary evidence for ancient ice ages. We present evidence of the surface features on clasts from known proximal ejecta debris-flow deposits and compare these features with those reported in diamictites. interpreted as ancient glacial deposits (tillites). Our purpose is to document the types of features seen on clasts in diamictites of ejecta origin in order to help in the interpretation of the origin of ancient diamictites. The recognition of characteristic features in clast populations in ancient diamictites may allow identification and discrimination of debris-flow deposits of various origins (e.g., impact glacial, tectonic) and may shed light on some climatic paradoxes, such as inferred Proterozoic glaciations at low paleolatitudes.

Moving Knowledge Acquisition From the Lecture Hall to the Student Home: A Prospective Intervention Study.

PubMed

Raupach, Tobias; Grefe, Clemens; Brown, Jamie; Meyer, Katharina; Schuelper, Nikolai; Anders, Sven

2015-09-28

Podcasts are popular with medical students, but the impact of podcast use on learning outcomes in undergraduate medical education has not been studied in detail. Our aim was to assess the impact of podcasts accompanied by quiz questions and lecture attendance on short- and medium-term knowledge retention. Students enrolled for a cardio-respiratory teaching module were asked to prepare for 10 specific lectures by watching podcasts and submitting answers to related quiz questions before attending live lectures. Performance on the same questions was assessed in a surprise test and a retention test. Watching podcasts and submitting answers to quiz questions (versus no podcast/quiz use) was associated with significantly better test performance in all items in the surprise test and 7 items in the retention test. Lecture attendance (versus no attendance) was associated with higher test performance in 3 items and 1 item, respectively. In a linear regression analysis adjusted for age, gender, and overall performance levels, both podcast/quiz use and lecture attendance were significant predictors of student performance. However, the variance explained by podcast/quiz use was greater than the variance explained by lecture attendance in the surprise test (38.7% vs. 2.2%) and retention test (19.1% vs. 4.0%). When used in conjunction with quiz questions, podcasts have the potential to foster knowledge acquisition and retention over and above the effect of live lectures.

MECHANISMS OF MALE REPRODUCTIVE TOXICITY: BED, BATH AND BEYOND

EPA Science Inventory

Male reproductive function depends upon the integration of a great number of highly complex biological processes and their endocrine support. Therefore it is not surprising that male reproductive health can be impaired by exposures to drugs and environmental toxicants that impact...

The effect of pathological gambling on families, marriages, and children.

PubMed

Shaw, Martha C; Forbush, Kelsie T; Schlinder, Jessica; Rosenman, Eugene; Black, Donald W

2007-08-01

Pathological gambling (PG) is widely reported to have negative consequences on marriages, families, and children. Empirical evidence is only now accumulating but when put together with anecdotal information, the extent of these problems is clear. PG contributes to chaos and dysfunction within the family unit, disrupts marriages, leading to high rates of separation and divorce, and is associated with child abuse and neglect. Divorce rates are high, not surprising in light of reports that these marriages are often abusive. Research shows that the families of pathological gamblers are filled with members who gamble excessively, suffer from depressive or anxiety disorders, and misuse alcohol, drugs, or both. Families of persons with PG are also large, a variable independently related to family dysfunction. The authors review the evidence on the impact of PG on families, marriages, and offspring, and make recommendations for future research targeting these problems.

What precision-protein-tuning and nano-resolved single molecule sciences can do for each other.

PubMed

Milles, Sigrid; Lemke, Edward A

2013-01-01

While innovations in modern microscopy, spectroscopy, and nanoscopy techniques have made single molecule observation a standard in many laboratories, the actual design of meaningful fluorescence reporter systems now hinders major scientific breakthroughs. Even though the field of chemical biology is supercharging the fluorescence toolbox, surprisingly few strategies exist that make the transition from model systems to biologically relevant applications. At the same time, the number of microscopy techniques is growing dramatically. We explain our view on how the impact of modern technologies is influenced not only by further hard- and software developments, but also by the availability and suitability of protein-engineering tools. We identify how the largely independent research fields of chemical biology and fluorescence nanoscopy can influence each other to synergistically drive future technology that can visualize the localization, structure, and dynamics of molecular function without constraints. Copyright © 2013 WILEY Periodicals, Inc.

Morbid Obesity in Disasters: Bringing the “Conspicuously Invisible” into Focus

PubMed Central

Gray, Lesley; MacDonald, Carol

2016-01-01

It is a frightening reality for some people to be caught up in the midst of a disaster, alone and vulnerable due to their relative size, shape or weight. A literature search failed to find any empirical reports of data specific to body mass index (BMI) in disaster situations. A handful of largely anecdotal reports described situations in which people categorised as morbidly obese were negatively impacted in disasters because of their size and/or weight. While a small number of toolkits and training resources were found, there remains a paucity of research in relation to obesity and emergency planning or disaster risk reduction. This is somewhat surprising, considering the concern about increasing levels of obesity globally. Research is urgently needed to prioritise and address the specific considerations of people with morbid obesity and how communities plan, prepare, respond, and recover from disasters and public health emergencies. PMID:27775636

Mesocosms Reveal Ecological Surprises from Climate Change.

PubMed

Fordham, Damien A

2015-12-01

Understanding, predicting, and mitigating the impacts of climate change on biodiversity poses one of the most crucial challenges this century. Currently, we know more about how future climates are likely to shift across the globe than about how species will respond to these changes. Two recent studies show how mesocosm experiments can hasten understanding of the ecological consequences of climate change on species' extinction risk, community structure, and ecosystem functions. Using a large-scale terrestrial warming experiment, Bestion et al. provide the first direct evidence that future global warming can increase extinction risk for temperate ectotherms. Using aquatic mesocosms, Yvon-Durocher et al. show that human-induced climate change could, in some cases, actually enhance the diversity of local communities, increasing productivity. Blending these theoretical and empirical results with computational models will improve forecasts of biodiversity loss and altered ecosystem processes due to climate change.

Morbid Obesity in Disasters: Bringing the "Conspicuously Invisible" into Focus.

PubMed

Gray, Lesley; MacDonald, Carol

2016-10-20

It is a frightening reality for some people to be caught up in the midst of a disaster, alone and vulnerable due to their relative size, shape or weight. A literature search failed to find any empirical reports of data specific to body mass index (BMI) in disaster situations. A handful of largely anecdotal reports described situations in which people categorised as morbidly obese were negatively impacted in disasters because of their size and/or weight. While a small number of toolkits and training resources were found, there remains a paucity of research in relation to obesity and emergency planning or disaster risk reduction. This is somewhat surprising, considering the concern about increasing levels of obesity globally. Research is urgently needed to prioritise and address the specific considerations of people with morbid obesity and how communities plan, prepare, respond, and recover from disasters and public health emergencies.

Smartphone Response System Using Twitter to Enable Effective Interaction and Improve Engagement in Large Classrooms

ERIC Educational Resources Information Center

Kim, Yeongjun; Jeong, Soonmook; Ji, Yongwoon; Lee, Sangeun; Kwon, Key Ho; Jeon, Jae Wook

2015-01-01

This paper proposes a method for seamless interaction between students and their professor using Twitter, one of the typical social network service (SNS) platforms, in large lectures. During the lecture, the professor poses surprise questions in the form of a quiz on an overhead screen at unexpected moments, and students submit their answers…

The impacts of climate change on poverty in 2030, and the potential from rapid, inclusive and climate-informed development

NASA Astrophysics Data System (ADS)

Rozenberg, J.; Hallegatte, S.

2016-12-01

There is a consensus on the fact that poor people are more vulnerable to climate change than the rest of the population, but, until recently, few quantified estimates had been proposed and few frameworks existed to design policies for addressing the issue. In this paper, we analyze the impacts of climate change on poverty using micro-simulation approaches. We start from household surveys that describe the current distribution of income and occupations, we project these households into the future and we look at the impacts of climate change on people's income. To project households into the future, we explore a large range of assumptions on future demographic changes (including on education), technological changes, and socio-economic trends (including redistribution policies). This approach allows us to identify the main combination of factors that lead to fast poverty reduction, and the ones that lead to high climate change impacts on the poor. Identifying these factors is critical for designing efficient policies to protect the poorest from climate change impacts and making economic growth more inclusive. Conclusions are twofold. First, by 2030 climate change can have a large impact on poverty, with between 3 and 122 million more people in poverty, but climate change remains a secondary driver of poverty trends within this time horizon. Climate change impacts do not only affect the poorest: in 2030, the bottom 40 percent lose more than 4 percent of income in many countries. The regional hotspots are Sub-Saharan Africa and - to a lesser extent - India and the rest of South Asia. The most important channel through which climate change increases poverty is through agricultural income and food prices. Second, by 2030 and in the absence of surprises on climate impacts, inclusive climate-informed development can prevent most of (but not all) the impacts on poverty. In a scenario with rapid, inclusive and climate-proof development, climate change impact on poverty is between 3 and 16 million, vs. between 35 and 122 million if development is delayed and less inclusive. Development and inclusive policies appears to reduce the impact of climate change on poverty much more than it reduces aggregated losses expressed in percentage of GDP.

How Robust Is Your Project? From Local Failures to Global Catastrophes: A Complex Networks Approach to Project Systemic Risk.

PubMed

Ellinas, Christos; Allan, Neil; Durugbo, Christopher; Johansson, Anders

2015-01-01

Current societal requirements necessitate the effective delivery of complex projects that can do more while using less. Yet, recent large-scale project failures suggest that our ability to successfully deliver them is still at its infancy. Such failures can be seen to arise through various failure mechanisms; this work focuses on one such mechanism. Specifically, it examines the likelihood of a project sustaining a large-scale catastrophe, as triggered by single task failure and delivered via a cascading process. To do so, an analytical model was developed and tested on an empirical dataset by the means of numerical simulation. This paper makes three main contributions. First, it provides a methodology to identify the tasks most capable of impacting a project. In doing so, it is noted that a significant number of tasks induce no cascades, while a handful are capable of triggering surprisingly large ones. Secondly, it illustrates that crude task characteristics cannot aid in identifying them, highlighting the complexity of the underlying process and the utility of this approach. Thirdly, it draws parallels with systems encountered within the natural sciences by noting the emergence of self-organised criticality, commonly found within natural systems. These findings strengthen the need to account for structural intricacies of a project's underlying task precedence structure as they can provide the conditions upon which large-scale catastrophes materialise.

Patients' views of pay for performance in primary care: a qualitative study.

PubMed

Hannon, Kerin L; Lester, Helen E; Campbell, Stephen M

2012-05-01

Many countries use pay-for-performance schemes to reward family practices financially for achieving quality indicators. The views of patients on pay for performance remain largely unexplored. To gain the views of family practice patients on the United Kingdom pay-for-performance Quality and Outcomes Framework (QOF). Interviews with 52 patients were conducted in 15 family practices across England. All patients had at least one long-term condition that had been diagnosed before the introduction of the QOF in 2004. Semi-structured interviews analysed using open explorative thematic coding. Few patients had heard of the QOF or had noticed changes to the structure or process of their care. However, where they were noted, changes to consultations such as increased use of computers and health checks initiated by the GP or practice nurse were seen as good practice. The majority of patients were surprised to hear their practice received bonuses for doing 'simple things'. Some patients also raised concerns over potential unintended consequences of pay-for-performance frameworks, such as a reduced focus on non-incentivised areas. This study adds a unique patient perspective to the debate around the impact of pay-for-performance schemes and consequences on patient care. Patients' views, experiences, and concerns about pay for performance mostly chime with previously described opinions of primary care staff. Patient surprise and concern around incentivising basic processes of care shows how patient views are vital when monitoring and evaluating a scheme that is designed to improve patient care.

New insight into lunar impact melt mobility from the LRO camera

USGS Publications Warehouse

Bray, Veronica J.; Tornabene, Livio L.; Keszthelyi, Laszlo P.; McEwen, Alfred S.; Hawke, B. Ray; Giguere, Thomas A.; Kattenhorn, Simon A.; Garry, William B.; Rizk, Bashar; Caudill, C.M.; Gaddis, Lisa R.; van der Bogert, Carolyn H.

2010-01-01

The Lunar Reconnaissance Orbiter Camera (LROC) is systematically imaging impact melt deposits in and around lunar craters at meter and sub-meter scales. These images reveal that lunar impact melts, although morphologically similar to terrestrial lava flows of similar size, exhibit distinctive features (e.g., erosional channels). Although generated in a single rapid event, the post-impact mobility and morphology of lunar impact melts is surprisingly complex. We present evidence for multi-stage influx of impact melt into flow lobes and crater floor ponds. Our volume and cooling time estimates for the post-emplacement melt movements noted in LROC images suggest that new flows can emerge from melt ponds an extended time period after the impact event.

Oil price: Endless ability to surprise

NASA Astrophysics Data System (ADS)

Manzano, Baltasar

2016-05-01

Economic agents have varying expectations on oil price fluctuations that play an important role in determining the timing and magnitude of oil price shocks. A study now shows that heterogeneous expectations should be included when modelling oil price shocks to grasp their impact on macroeconomic outcomes and energy policies.

Human Impact on the Geomorphological Evolution of the Opak River Following the 2010 Large Volcanic Event of the Merapi (Indonesia)

NASA Astrophysics Data System (ADS)

Gob, F.; Gautier, E.; Virmoux, C.; Grancher, D.; Tamisier, V.; Primanda, K. W.; Wibowo, S. B.

2016-12-01

During large eruptions, active volcanos may introduce very large quantities of sediment to the drainage system through tephra falls and pyroclastic flows, thus modifying the river system. Once remobilized, the sediment inputs propagate downstream as a sediment wave modifying the channel geometry of the river and reloading the sediment cascade of the catchments. Considering the extreme nature of the volcanic events, the parameters that control the post-eruption evolution of the river system are generally only described as natural and the role played by human activities seems negligible. Communities that live on the volcano slopes and foothills are rather considered to suffer from natural disasters associated with the eruption and its consequences (lahars, etc.) or take advantage of the benefits of the volcanic environment (rich soil, mining and geothermal resources, etc.). This study examines the impact of human influence on the fluvial readjustment of a Javanese river impacted by a major eruption of the Merapi volcano (Indonesia) in October/November 2010. The basin of the Opak River was subject to substantial sediment input related to massive pyroclastic deposits that were remobilized by numerous lahars during the year after the eruption. Two study sites were equipped in order to evaluate the morphodynamic evolution of the riverbed of the Opak River. Topographic surveys, bedload particle marking and suspended sediment sampling revealed an important sediment mobilization during efficient flash-floods. Surprisingly, no bed aggradation related to the progradation of a sediment wave was observed. Two years after the eruptive event, marked bed incision was observed. The Opak River readjustment differs from that of other fluvial systems affected by massive eruptions in two ways. Firstly, the local population massively extracted the sand and blocks injected by the eruption as they represent a valuable economic resource. Secondly, several dams trapped the major part of the sediment load remobilized by lahars.

On the rarity of big fierce carnivores and primacy of isolation and area: tracking large mammalian carnivore diversity on two isolated continents.

PubMed Central

Wroe, Stephen; Argot, Christine; Dickman, Christopher

2004-01-01

The hypothesis that low productivity has uniquely constrained Australia's large mammalian carnivore diversity, and by inference the biota in general, has become an influential backdrop to interpretations of ecology on the island continent. Whether low productivity has been primary impacts broadly on our understanding of mammalian biogeography, but investigation is complicated by two uniquely Australian features: isolation and the dominance of marsupials. However, until the great American biotic interchange (GABI), South America was also isolated and dominated by pouched carnivores. Here, we examine the low-productivity hypothesis empirically, by comparing large mammalian carnivore diversities in Australia and South America over the past 25 Myr. We find that pre-GABI diversity in Australia was generally comparable to or higher than diversity in South America. Post-GABI, South American diversity rose dramatically, pointing to isolation and phylogenetic constraint as primary influences. Landmass area is another important factor. Comparisons of diversity among the world's seven largest inhabited landmasses show that large mammalian hypercarnivore diversity in Australia approached levels predicted on the basis of landmass area in Late Pleistocene-Recent times, but large omnivore diversity was low. Large marsupial omnivores also appear to have been rare in South America. Isolation and competition with large terrestrial birds and cryptic omnivore taxa may have been more significant constraints in this respect. Relatively high diversity has been achieved in Late Quaternary America, possibly as a result of 'artificially' high immigration or origination rates, whereas that in contemporaneous Africa has been surprisingly poor. We conclude that isolation and landmass area, rather than productivity, are the primary constraints on large mammalian carnivore diversity. Our results quantify the rarity of large hypercarnivorous mammals worldwide. PMID:15306371

On the rarity of big fierce carnivores and primacy of isolation and area: tracking large mammalian carnivore diversity on two isolated continents.

PubMed

Wroe, Stephen; Argot, Christine; Dickman, Christopher

2004-06-07

The hypothesis that low productivity has uniquely constrained Australia's large mammalian carnivore diversity, and by inference the biota in general, has become an influential backdrop to interpretations of ecology on the island continent. Whether low productivity has been primary impacts broadly on our understanding of mammalian biogeography, but investigation is complicated by two uniquely Australian features: isolation and the dominance of marsupials. However, until the great American biotic interchange (GABI), South America was also isolated and dominated by pouched carnivores. Here, we examine the low-productivity hypothesis empirically, by comparing large mammalian carnivore diversities in Australia and South America over the past 25 Myr. We find that pre-GABI diversity in Australia was generally comparable to or higher than diversity in South America. Post-GABI, South American diversity rose dramatically, pointing to isolation and phylogenetic constraint as primary influences. Landmass area is another important factor. Comparisons of diversity among the world's seven largest inhabited landmasses show that large mammalian hypercarnivore diversity in Australia approached levels predicted on the basis of landmass area in Late Pleistocene-Recent times, but large omnivore diversity was low. Large marsupial omnivores also appear to have been rare in South America. Isolation and competition with large terrestrial birds and cryptic omnivore taxa may have been more significant constraints in this respect. Relatively high diversity has been achieved in Late Quaternary America, possibly as a result of 'artificially' high immigration or origination rates, whereas that in contemporaneous Africa has been surprisingly poor. We conclude that isolation and landmass area, rather than productivity, are the primary constraints on large mammalian carnivore diversity. Our results quantify the rarity of large hypercarnivorous mammals worldwide.

RNA antitoxins.

PubMed

Gerdes, Kenn; Wagner, E Gerhart H

2007-04-01

Recent genomic analyses revealed a surprisingly large number of toxin-antitoxin loci in free-living prokaryotes. The antitoxins are proteins or antisense RNAs that counteract the toxins. Two antisense RNA-regulated toxin-antitoxin gene families, hok/sok and ldr, are unrelated sequence-wise but have strikingly similar properties at the level of gene and RNA organization. Recently, two SOS-induced toxins were found to be regulated by RNA antitoxins. One such toxin, SymE, exhibits similarity with MazE antitoxin and, surprisingly, inhibits translation. Thus, it is possible that an ancestral antitoxin gene evolved into the present toxin gene (symE) whose translation is repressed by an RNA antitoxin (SymR).

Experience with the President's Science Advisory Committee, Its Panels, and Other Modes of Advice

NASA Astrophysics Data System (ADS)

Garwin, Richard

2012-03-01

When Dwight Eisenhower became President in January 1953, the United States had just tested November 1, 1952 its 11 megaton prototype of a hydrogen bomb, and Eisenhower sought enduring peace and economy by basing the U.S. military strategy on nuclear weaponry and a downsizing of the military forces. The detonation by the Soviet Union of a 400-kt fusion-containing device in August 1953 enhanced concern about U.S. vulnerability, and in early 1954 the unexpectedly large yield of the BRAVO test elevated fears for the actual survival of societies against the nuclear threat. Eisenhower initially sought a world moratorium on nuclear tests, but was unable to win over his Administration and met with an obscure Scientific Advisory Committee of the Office of Defense Mobilization (SAC-ODM) on March 27, 1954 for a mutual exploration of what science and technology might bring to national security. The resulting 42-man (!) Technological Capabilities Panel (TCP) had a remarkable impact on the President himself and the direction of the country's strategic missile and intelligence activities and structure, as well as a new emphasis on federal support of university research. Rooted in MIT Summer Studies, the TCP reported on March 17, 1955 on the problems of surprise attack, the overall U.S. offensive capability, and, especially, on its Part V, ``Intelligence: Our First Defense Against Surprise.'' That panel, chaired by Edwin Land, inventor of polarizing sheet and instant photography, originated the U-2 and OXCART (SR-71) strategic reconnaissance aircraft and the CORONA film-return imaging satellites. The President's Science Advisory Committee (PSAC) was created in the White House in 1957 from the SAC-ODM and had major impact throughout the 1960s until its termination by President Richard Nixon in 1973. The presentation traces its story and that of some of its panels from personal experience of the author and his colleagues.

Moving Knowledge Acquisition From the Lecture Hall to the Student Home: A Prospective Intervention Study

PubMed Central

Grefe, Clemens; Brown, Jamie; Meyer, Katharina; Schuelper, Nikolai; Anders, Sven

2015-01-01

Background Podcasts are popular with medical students, but the impact of podcast use on learning outcomes in undergraduate medical education has not been studied in detail. Objective Our aim was to assess the impact of podcasts accompanied by quiz questions and lecture attendance on short- and medium-term knowledge retention. Methods Students enrolled for a cardio-respiratory teaching module were asked to prepare for 10 specific lectures by watching podcasts and submitting answers to related quiz questions before attending live lectures. Performance on the same questions was assessed in a surprise test and a retention test. Results Watching podcasts and submitting answers to quiz questions (versus no podcast/quiz use) was associated with significantly better test performance in all items in the surprise test and 7 items in the retention test. Lecture attendance (versus no attendance) was associated with higher test performance in 3 items and 1 item, respectively. In a linear regression analysis adjusted for age, gender, and overall performance levels, both podcast/quiz use and lecture attendance were significant predictors of student performance. However, the variance explained by podcast/quiz use was greater than the variance explained by lecture attendance in the surprise test (38.7% vs 2.2%) and retention test (19.1% vs 4.0%). Conclusions When used in conjunction with quiz questions, podcasts have the potential to foster knowledge acquisition and retention over and above the effect of live lectures. PMID:26416467

W production at large transverse momentum at the CERN Large Hadron Collider.

PubMed

Gonsalves, Richard J; Kidonakis, Nikolaos; Sabio Vera, Agustín

2005-11-25

We study the production of W bosons at large transverse momentum in pp collisions at the CERN Large Hadron Collider. We calculate the complete next-to-leading order (NLO) corrections to the differential cross section. We find that the NLO corrections provide a large increase to the cross section but, surprisingly, do not reduce the scale dependence relative to leading order (LO). We also calculate next-to-next-to-leading-order (NNLO) soft-gluon corrections and find that, although they are small, they significantly reduce the scale dependence thus providing a more stable result.

Water walking - an evolution of water surface skipping

NASA Astrophysics Data System (ADS)

Hurd, Randy; Belden, Jesse; Jandron, Michael; Bower, Allan; Holekamp, Sean; Truscott, Tadd

2017-11-01

Previous work has shown that elastomeric spheres skip more easily than disk-shaped stones. This is due to increased lift stemming from sphere deformation, which provides an increased cross-sectional area and favorable attack angle upon impact. We extend lift models developed for individual impacts to long-range multiple impact events and compare the estimates to experimental results, which show good agreement. Additionally, a surprising new mode of skipping is observed that resembles water-walking, wherein a quickly rotating sphere produces small successive impacts allowing it to move parallel to the water surface. The dynamics of this new multiple skip behavior are rationalized analytically and tested experimentally.

Mitigating Aviation Communication and Satellite Orbit Operations Surprises from Adverse Space Weather

NASA Technical Reports Server (NTRS)

Tobiska, W. Kent

2008-01-01

Adverse space weather affects operational activities in aviation and satellite systems. For example, large solar flares create highly variable enhanced neutral atmosphere and ionosphere electron density regions. These regions impact aviation communication frequencies as well as precision orbit determination. The natural space environment, with its dynamic space weather variability, is additionally changed by human activity. The increase in orbital debris in low Earth orbit (LEO), combined with lower atmosphere CO2 that rises into the lower thermosphere and causes increased cooling that results in increased debris lifetime, adds to the environmental hazards of navigating in near-Earth space. This is at a time when commercial space endeavors are posed to begin more missions to LEO during the rise of the solar activity cycle toward the next maximum (2012). For satellite and aviation operators, adverse space weather results in greater expenses for orbit management, more communication outages or aviation and ground-based high frequency radio used, and an inability to effectively plan missions or service customers with space-based communication, imagery, and data transferal during time-critical activities. Examples of some revenue-impacting conditions and solutions for mitigating adverse space weather are offered.

Dietary and developmental shifts in butterfly-associated bacterial communities

PubMed Central

2018-01-01

Bacterial communities associated with insects can substantially influence host ecology, evolution and behaviour. Host diet is a key factor that shapes bacterial communities, but the impact of dietary transitions across insect development is poorly understood. We analysed bacterial communities of 12 butterfly species across different developmental stages, using amplicon sequencing of the 16S rRNA gene. Butterfly larvae typically consume leaves of a single host plant, whereas adults are more generalist nectar feeders. Thus, we expected bacterial communities to vary substantially across butterfly development. Surprisingly, only few species showed significant dietary and developmental transitions in bacterial communities, suggesting weak impacts of dietary transitions across butterfly development. On the other hand, bacterial communities were strongly influenced by butterfly species and family identity, potentially due to dietary and physiological variation across the host phylogeny. Larvae of most butterfly species largely mirrored bacterial community composition of their diets, suggesting passive acquisition rather than active selection. Overall, our results suggest that although butterflies harbour distinct microbiomes across taxonomic groups and dietary guilds, the dramatic dietary shifts that occur during development do not impose strong selection to maintain distinct bacterial communities across all butterfly hosts. PMID:29892359

Global Coupled Carbon and Nitrogen Models: Successes, Failures and What next?

NASA Astrophysics Data System (ADS)

Holland, E. A.

2011-12-01

Over the last few years, there has been a great deal of progress in modeling coupled terrestrial global carbon and nitrogen cycles and their roles in Earth System models. The collection of recent models provides some surprising results and insights. A critical question for Earth system models is: How do the coupled C/N model results impact atmospheric carbon dioxide concentrations compared to carbon only models? Some coupled models predict increased atmospheric carbon dioxide concentrations, the result expected from nitrogen-limited photosynthesis uptake of carbon dioxide, while others predict little change or decreased carbon dioxide uptake with a coupled carbon and nitrogen cycle. With this range of impacts for climate critical atmospheric carbon dioxide concentrations, there is clearly a need for additional comparison of measurements and models. Randerson et al.'s CLAMP study provided important constraints and comparison for primarily for aboveground carbon uptake. However, nitrogen supply is largely determined decomposition and soil processes. I will present comparisons of NCAR's CESM results with soil and litter carbon and nitrogen fluxes and standing stocks. These belowground data sets of both carbon and nitrogen provide important benchmarks for coupled C/N models.

Lowering Barriers to Undergraduate Research through Collaboration with Local Craft Breweries

ERIC Educational Resources Information Center

McDermott, M. Luke

2016-01-01

Laboratory research experiences are highly impactful learning environments for undergraduate students. However, a surprising number of chemistry students do not research. These students often do not research because they lack the time, interest, opportunity, or awareness. Course-based undergraduate research experiences can reach out to these…

Philanthropy, Public Needs, and Nonpublic Schools. A Report.

ERIC Educational Resources Information Center

Erickson, Donald A.

Nonpublic schools are a surprisingly salient channel for philanthropy in elementary and secondary education. As a result of philanthropy in nonpublic schools, the nation's total collectivity of schools is probably more efficient fiscally, more effective educationally, and more humane in its impact on students and parents than an exclusively public…

Human Capital Theory: A Holistic Criticism

ERIC Educational Resources Information Center

Tan, Emrullah

2014-01-01

Human capital theory has had a profound impact on a range of disciplines from economics to education and sociology. The theory has always been the subject of bitter criticisms from the very beginning, but it has comfortably survived and expanded its influence over other research disciplines. Not surprisingly, a considerable number of criticisms…

Metrication -- A Construction Point of View

ERIC Educational Resources Information Center

Stein, Joseph

1974-01-01

Random sampling of construction executives revealed a surprising lack of awareness concerning the proposed 10-year metric conversion recommendation made by the National Bureau of Standards in 1971. Explains attitudes on the desirability of conversion to the metric system and prognoses on the impact of conversion. (A paper presented at Building…

Development and Validation of the Game Perception Scale (GPS)

ERIC Educational Resources Information Center

Vandercruysse, Sylke; Vandewaetere, Mieke; Maertens, Marie; ter Vrugte, Judith; Wouters, Pieter; de Jong, Ton; van Oostendorp, Herre; Elen, Jan

2015-01-01

Despite the pervasiveness of perception and considerable impact of perception on the use of ICT for educational purposes, there is a surprising paucity of perception assessment instruments. The present proposal expands on this through the development and initial validation of the Game Perception Scale (GPS). Based on perception literature,…

TinkerPlots™ Model Construction Approaches for Comparing Two Groups: Student Perspectives

ERIC Educational Resources Information Center

Noll, Jennifer; Kirin, Dana

2017-01-01

Teaching introductory statistics using curricula focused on modeling and simulation is becoming increasingly common in introductory statistics courses and touted as a more beneficial approach for fostering students' statistical thinking. Yet, surprisingly little research has been conducted to study the impact of modeling and simulation curricula…

Arctic skate Amblyraja hyperborea preys on remarkably large glacial eelpouts Lycodes frigidus.

PubMed

Byrkjedal, I; Christiansen, J S; Karamushko, O V; Langhelle, G; Lynghammar, A

2015-01-01

During scientific surveys on the continental slopes north-west of Spitsbergen and off north-east Greenland (c. 600 and 1000 m depths), two female Arctic skates Amblyraja hyperborea were caught while swallowing extraordinary large individuals of glacial eelpout Lycodes frigidus. The total length (LT) of the prey constituted 50 and 80% of the LT of the skates, which reveal that A. hyperborea are capable predators of fishes of surprisingly large relative size. © 2014 The Fisheries Society of the British Isles.

The mechanism of impact of summative assessment on medical students’ learning

PubMed Central

Schuwirth, Lambert W.; Adendorff, Hanelie J.; Herman, Nicoline; van der Vleuten, Cees P.

2010-01-01

It has become axiomatic that assessment impacts powerfully on student learning, but there is a surprising dearth of research on how. This study explored the mechanism of impact of summative assessment on the process of learning of theory in higher education. Individual, in-depth interviews were conducted with medical students and analyzed qualitatively. The impact of assessment on learning was mediated through various determinants of action. Respondents’ learning behaviour was influenced by: appraising the impact of assessment; appraising their learning response; their perceptions of agency; and contextual factors. This study adds to scant extant evidence and proposes a mechanism to explain this impact. It should help enhance the use of assessment as a tool to augment learning. PMID:20455078

Observational evidence for volcanic impact on sea level and the global water cycle

PubMed Central

Grinsted, A.; Moore, J. C.; Jevrejeva, S.

2007-01-01

It has previously been noted that there are drops in global sea level (GSL) after some major volcanic eruptions. However, observational evidence has not been convincing because there is substantial variability in the global sea level record over periods similar to those at which we expect volcanoes to have an impact. To quantify the impact of volcanic eruptions we average monthly GSL data from 830 tide gauge records around five major volcanic eruptions. Surprisingly, we find that the initial response to a volcanic eruption is a significant rise in sea level of 9 ± 3 mm in the first year after the eruption. This rise is followed by a drop of 7 ± 3 mm in the period 2–3 years after the eruption relative to preeruption sea level. These results are statistically robust and no particular volcanic eruption or ocean region dominates the signature we find. Neither the drop nor especially the rise in GSL can be explained by models of lower oceanic heat content. We suggest that the mechanism is a transient disturbance of the water cycle with a delayed response of land river runoff relative to ocean evaporation and global precipitation that affects global sea level. The volcanic impact on the water cycle and sea levels is comparable in magnitude to that of a large El Niño–La Niña cycle, amounting to ≈5% of global land precipitation. PMID:18056644

Probability and surprisal in auditory comprehension of morphologically complex words.

PubMed

Balling, Laura Winther; Baayen, R Harald

2012-10-01

Two auditory lexical decision experiments document for morphologically complex words two points at which the probability of a target word given the evidence shifts dramatically. The first point is reached when morphologically unrelated competitors are no longer compatible with the evidence. Adapting terminology from Marslen-Wilson (1984), we refer to this as the word's initial uniqueness point (UP1). The second point is the complex uniqueness point (CUP) introduced by Balling and Baayen (2008), at which morphologically related competitors become incompatible with the input. Later initial as well as complex uniqueness points predict longer response latencies. We argue that the effects of these uniqueness points arise due to the large surprisal (Levy, 2008) carried by the phonemes at these uniqueness points, and provide independent evidence that how cumulative surprisal builds up in the course of the word co-determines response latencies. The presence of effects of surprisal, both at the initial uniqueness point of complex words, and cumulatively throughout the word, challenges the Shortlist B model of Norris and McQueen (2008), and suggests that a Bayesian approach to auditory comprehension requires complementation from information theory in order to do justice to the cognitive cost of updating probability distributions over lexical candidates. Copyright © 2012 Elsevier B.V. All rights reserved.

Interactions among invasive plants: Lessons from Hawai‘i

USGS Publications Warehouse

D'Antonio, Carla M.; Ostertag, Rebecca; Cordell, Susan; Yelenik, Stephanie G.

2017-01-01

Most ecosystems have multiple-plant invaders rather than single-plant invaders, yet ecological studies and management actions focus largely on single invader species. There is a need for general principles regarding invader interactions across varying environmental conditions, so that secondary invasions can be anticipated and managers can allocate resources toward pretreatment or postremoval actions. By reviewing removal experiments conducted in three Hawaiian ecosystems (a dry tropical forest, a seasonally dry mesic forest, and a lowland wet forest), we evaluate the roles environmental harshness, priority effects, productivity potential, and species interactions have in influencing secondary invasions, defined here as invasions that are influenced either positively (facilitation) or negatively (inhibition/priority effects) by existing invaders. We generate a conceptual model with a surprise index to describe whether long-term plant invader composition and dominance is predictable or stochastic after a system perturbation such as a removal experiment. Under extremely low resource availability, the surprise index is low, whereas under intermediate-level resource environments, invader dominance is more stochastic and the surprise index is high. At high resource levels, the surprise index is intermediate: Invaders are likely abundant in the environment but their response to a perturbation is more predictable than at intermediate resource levels. We suggest further testing across environmental gradients to determine key variables that dictate the predictability of postremoval invader composition.

Mine waste disposal leads to lower coral cover, reduced species richness and a predominance of simple coral growth forms on a fringing coral reef in Papua New Guinea.

PubMed

Haywood, M D E; Dennis, D; Thomson, D P; Pillans, R D

2016-04-01

A large gold mine has been operating at the Lihir Island Group, Papua New Guinea since 1997. The mine disposes of waste rock in nearshore waters, impacting nearby coral communities. During 2010, 2012 we conducted photographic surveys at 73 sites within 40 km of the mine to document impacts of mining operations on the hard coral communities. Coral communities close to the mine (∼2 km to the north and south of the mine) were depaurperate, but surprisingly, coral cover and community composition beyond this range appeared to be relatively similar, suggesting that the mine impacts were limited spatially. In particular, we found mining operations have resulted in a significant decrease in coral cover (4.4% 1.48 km from the disposal site c.f. 66.9% 10.36 km from the disposal site), decreased species richness and a predominance of less complex growth forms within ∼2 km to the north and south of the mine waste disposal site. In contrast to the two 'snapshot' surveys of corals performed in 2010 and 2012, long term data (1999-2012) based on visual estimates of coral cover suggested that impacts on coral communities may have been more extensive than this. With global pressures on the world's coral reefs increasing, it is vital that local, direct anthropogenic pressures are reduced, in order to help offset the impacts of climate change, disease and predation. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

Are all "research fields" equal? Rethinking practice for the use of data from crowdsourcing market places.

PubMed

Gleibs, Ilka H

2017-08-01

New technologies like large-scale social media sites (e.g., Facebook and Twitter) and crowdsourcing services (e.g., Amazon Mechanical Turk, Crowdflower, Clickworker) are impacting social science research and providing many new and interesting avenues for research. The use of these new technologies for research has not been without challenges, and a recently published psychological study on Facebook has led to a widespread discussion of the ethics of conducting large-scale experiments online. Surprisingly little has been said about the ethics of conducting research using commercial crowdsourcing marketplaces. In this article, I focus on the question of which ethical questions are raised by data collection with crowdsourcing tools. I briefly draw on the implications of Internet research more generally, and then focus on the specific challenges that research with crowdsourcing tools faces. I identify fair pay and the related issue of respect for autonomy, as well as problems with the power dynamic between researcher and participant, which has implications for withdrawal without prejudice, as the major ethical challenges of crowdsourced data. Furthermore, I wish to draw attention to how we can develop a "best practice" for researchers using crowdsourcing tools.

Acehnese reefs in the wake of the Asian tsunami.

PubMed

Baird, Andrew H; Campbell, Stuart J; Anggoro, Aji W; Ardiwijaya, Rizya L; Fadli, Nur; Herdiana, Yudi; Kartawijaya, Tasrif; Mahyiddin, Dodent; Mukminin, Ahmad; Pardede, Shinta T; Pratchett, Morgan S; Rudi, Edi; Siregar, Achis M

2005-11-08

The Sumatra-Andanaman tsunami was one of the greatest natural disasters in recorded human history. Here, we show that on the northwest coast of Aceh, Indonesia, where the tsunami was most ferocious, the damage to corals, although occasionally spectacular, was surprisingly limited. We detected no change in shallow coral assemblages between March 2003 and March 2005, with the exception of one site smothered by sediment. Direct tsunami damage was dependent on habitat and largely restricted to corals growing in unconsolidated substrata, a feature unique to tsunami disturbance. Reef condition, however, varied widely within the region and was clearly correlated with human impacts prior to the tsunami. Where fishing has been controlled, coral cover was high. In contrast, reefs exposed to destructive fishing had low coral cover and high algal cover, a phase shift the tsunami may exacerbate with an influx of sediments and nutrients. Healthy reefs did not mitigate the damage on land. Inundation distance was largely determined by wave height and coastal topography. We conclude that although chronic human misuse has been much more destructive to reefs in Aceh than this rare natural disturbance, human modification of the reef did not contribute to the magnitude of damage on land.

Unconventional Nanoscale Photoresponse and Degradation Process in Hybrid Organic-inorganic Perovskites.

NASA Astrophysics Data System (ADS)

Chu, Zhaodong; Yang, Mengjin; Schulz, Philip; Wu, Di; Zhu, Kai; Li, Xiaoqin; Lai, Keji

The remarkable performance of organic-inorganic perovskite solar cells (PSCs) is challenging the dogma that solution-processed thin films are inevitably associated with inferior energy conversion efficiencies. The surprisingly low impact of polycrystallinity on the film quality highlights the unusual photo-response of intrinsic defects and grain boundaries in these materials. Here, we report the first quantitative nanoscale photoconductivity imaging on methylammonium lead triiodide (MAPbI3) thin films by microwave impedance microscopy with light stimulation. The local photoconductivity as a function of the above-gap laser power is consistent with the high carrier mobility and long lifetime of MAPbI3. The photo-response is largely uniform across grains and grain boundaries, which is direct evidence on the inherently benign nature of microstructures in the perovskite thin films. For encapsulated MAPbI3 films, the observed long-term degradation in photoconductivity begins with the disintegration of large grains due to the diffusion of water molecules through the capping layer. Our work suggests that the striking PSC performance is deeply rooted in the nanoscale optoelectronic properties of MAPbI3. We gratefully acknowledge financial support from NSF EFMA-1542747.

A large, benign prostatic cyst presented with an extremely high serum prostate-specific antigen level.

PubMed

Chen, Han-Kuang; Pemberton, Richard

2016-01-08

We report a case of a patient who presented with an extremely high serum prostate specific antigen (PSA) level and underwent radical prostatectomy for presumed prostate cancer. Surprisingly, the whole mount prostatectomy specimen showed only small volume, organ-confined prostate adenocarcinoma and a large, benign intraprostatic cyst, which was thought to be responsible for the PSA elevation. 2016 BMJ Publishing Group Ltd.

Shock waves in weakly compressed granular media.

PubMed

van den Wildenberg, Siet; van Loo, Rogier; van Hecke, Martin

2013-11-22

We experimentally probe nonlinear wave propagation in weakly compressed granular media and observe a crossover from quasilinear sound waves at low impact to shock waves at high impact. We show that this crossover impact grows with the confining pressure P0, whereas the shock wave speed is independent of P0-two hallmarks of granular shocks predicted recently. The shocks exhibit surprising power law attenuation, which we model with a logarithmic law implying that shock dissipation is weak and qualitatively different from other granular dissipation mechanisms. We show that elastic and potential energy balance in the leading part of the shocks.

Exposure to environmental tobacco smoke in the workplace and the impact of away-from-work exposure

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaKind, J.S.; Graves, C.G.; Tardiff, R.G.

Concentrating on exposure in workplaces where smoking occurs, the authors examined environmental tobacco smoke (ETS)-related concentration data from the 16-City Study. This study involved a large population of nonsmokers, used personal monitors, and encompassed a wide selection of ETS-related constituents. This first article in a series of three describes the 16-City Study, considers the impact of demographic variables, and concludes that these variables did not explain differences in exposure to ETS. The authors compared 16-City Study concentrations obtained in the workplace to previously reported workplace concentrations and determined that data from this study were representative of current ETS exposure inmore » nonmanufacturing workplaces where smoking occurs. Considering factors other than demographic factors, they found that, not surprisingly, the number of cigarettes observed in the workplace had an impact on exposure concentrations. Finally, they compared people from homes where smoking occurs with people from nonsmoking homes and found that people from smoking homes observed more smoking in the workplace and experienced higher concentrations of ETS-related compounds in the workplace, even when they observed the same number of cigarettes being smoked in the workplace. In two subsequent articles in this series, they discuss relationships between various ETS markers and provide estimates of distributions of doses to nonsmoking workers employed in workplaces where smoking occurs.« less

The role of water tracks in altering biotic and abiotic soil properties and processes in a polar desert in Antarctica

NASA Astrophysics Data System (ADS)

Ball, Becky A.; Levy, Joseph

2015-02-01

Groundwater discharge via water tracks is a largely unexplored passageway routing salts and moisture from high elevations to valley floors in the McMurdo Dry Valleys (MDV) of Antarctica. Given the influence that water tracks have on the distribution of liquid water in seasonally thawed Antarctic soils, it is surprising how little is known about their role in structuring biotic and abiotic processes this cold desert ecosystem. Particularly, it is unclear how soil biota will respond to the activation of new water tracks resulting from enhanced active layer thickening or enhanced regional snowmelt. In the MDV, water tracks are both wetter and more saline than the surrounding soils, constituting a change in soil habitat suitability for soil biology and therefore the ecological processes they carry out. To investigate the net impact that water tracks have on Dry Valley soil biology, and therefore the ecosystem processes for which they are responsible, we analyzed microbial biomass and activity in soils inside and outside of three water tracks and relate this to the physical soil characteristics. Overall, our results suggest that water tracks can significantly influence soil properties, which can further impact biological biovolume and both biotic and abiotic fluxes of CO2. However, the nature of its impact differs with water track, further suggesting that not all water tracks can be regarded the same.

The surprising rolling spool: librational motion and failure of the pure rolling condition

NASA Astrophysics Data System (ADS)

Onorato, P.; Malgieri, M.; Mascheretti, P.; De Ambrosis, A.

2015-05-01

In a previous work (Onorato P, Malgieri M, Mascheretti P and De Ambrosis A 2014 The surprising rolling spool: experiments and theory from mechanics to phase transitions Eur. J. Phys. 35 055011) an asymmetric rolling spool (ARS) was investigated as a simple model for a second-order phase transition. Here, we deepen the study of this system to address critical aspects related both to the characteristic of the oscillatory anharmonic motion and to the role of friction forces in determining it. The experimental data show that for largely asymmetric bodies the rolling condition is not reliably fulfilled because the intensity of the friction force goes below the needed value to ensure rolling without slipping.

Responding to Nonwords in the Lexical Decision Task: Insights from the English Lexicon Project

ERIC Educational Resources Information Center

Yap, Melvin J.; Sibley, Daragh E.; Balota, David A.; Ratcliff, Roger; Rueckl, Jay

2015-01-01

Researchers have extensively documented how various statistical properties of words (e.g., word frequency) influence lexical processing. However, the impact of lexical variables on nonword decision-making performance is less clear. This gap is surprising, because a better specification of the mechanisms driving nonword responses may provide…

The Riddle of the Smart Machines

ERIC Educational Resources Information Center

Howell, Dusti D.

2010-01-01

Hundreds of graduate students were introduced to the fields of instructional design and educational technology with the riddle of the smart machines, yet over the years no one has answered it correctly. After revealing the surprising answer to this riddle, both the negative and positive impacts of smart machines are analyzed. An example of this is…

A Model of the Pre-Assessment Learning Effects of Summative Assessment in Medical Education

ERIC Educational Resources Information Center

Cilliers, Francois J.; Schuwirth, Lambert W. T.; Herman, Nicoline; Adendorff, Hanelie J.; van der Vleuten, Cees P. M.

2012-01-01

It has become axiomatic that assessment impacts powerfully on student learning. However, surprisingly little research has been published emanating from authentic higher education settings about the nature and mechanism of the pre-assessment learning effects of summative assessment. Less still emanates from health sciences education settings. This…

The Moderating Effects of School Climate on Bullying Prevention Efforts

ERIC Educational Resources Information Center

Low, Sabina; Van Ryzin, Mark

2014-01-01

Bullying prevention efforts have yielded mixed effects over the last 20 years. Program effectiveness is driven by a number of factors (e.g., program elements and implementation), but there remains a dearth of understanding regarding the role of school climate on the impact of bullying prevention programs. This gap is surprising, given research…

Understanding and Preventing Violence Directed against Teachers: Recommendations for a National Research, Practice, and Policy Agenda

ERIC Educational Resources Information Center

Espelage, Dorothy; Anderman, Eric M.; Brown, Veda Evanell; Jones, Abraham; Lane, Kathleen Lynne; McMahon, Susan D.; Reddy, Linda A.; Reynolds, Cecil R.

2013-01-01

Violence directed against K-12 teachers is a serious problem that demands the immediate attention of researchers, providers of teacher pre-service and in-service training, school administrators, community leaders, and policymakers. Surprisingly, little research has been conducted on this growing problem despite the broad impact teacher…

Considering Life Cycle during Design: A Longitudinal Study of Engineering Undergraduates. Research Brief

ERIC Educational Resources Information Center

Yasuhara, Ken; Morozov, Andrew; Kilgore, Deborah; Atman, Cynthia; Loucks-Jaret, Christine

2009-01-01

In this age of global warming and diminishing fossil fuel stores, society is becoming increasingly aware that seemingly small decisions can have surprisingly far-reaching implications on the environment and future generations. Accordingly, today's engineers must approach design problems with a holistic, broad view of the impacts,…

Touch Tablet Surprises: A Preschool Teacher's Story

ERIC Educational Resources Information Center

Shifflet, Rena; Toledo, Cheri; Mattoon, Cassandra

2012-01-01

A year and a half ago, Rena, Cheri, and Cassandra were introduced to each other by a colleague because they shared an interest in exploring the impact newer technologies have on learning in early childhood classrooms. They meet regularly to share ideas and information on how to incorporate tablets using best practices. Cassandra's preschool…

ED QUEST: A Model Procedure for Futures Planning in Educational Organizations.

ERIC Educational Resources Information Center

Adams, Charles F.

Most educational planning models are weak at identifying future events and assessing their impact on education. At best they assume a surprise-free future in which present trends continue unabated and interrelationships among social, economic, political, and technological forces stay the same. The ED QUEST model was developed to ameliorate these…

Time to Demonstrate How We Impact Student Learning

ERIC Educational Resources Information Center

Roberts, Georgi

2014-01-01

With the recent emphasis on evaluating teachers' effectiveness by the performance of their students, it should be no surprise that this subject has reached the physical education (PE) sector. This commentary examines 3 articles by Rink (2013), McKenzie and Lounsbery (2013), and Ward (2013), who each take a different perspective on measuring…

The Impact of Occupational Specialty and Soldier Gender on First Enlisted Attrition

DTIC Science & Technology

1984-03-01

mostly involuntary. It may be surprising that highly educated women with high aptitude sep, arate from the Army relatively often because of pregnancy...separation are rela- tively less frequent because of the ipsative nature of these proportions. This may be the only reason why highly educated women separate

Large Electroweak Corrections to Vector-Boson Scattering at the Large Hadron Collider.

PubMed

Biedermann, Benedikt; Denner, Ansgar; Pellen, Mathieu

2017-06-30

For the first time full next-to-leading-order electroweak corrections to off-shell vector-boson scattering are presented. The computation features the complete matrix elements, including all nonresonant and off-shell contributions, to the electroweak process pp→μ^{+}ν_{μ}e^{+}ν_{e}jj and is fully differential. We find surprisingly large corrections, reaching -16% for the fiducial cross section, as an intrinsic feature of the vector-boson-scattering processes. We elucidate the origin of these large electroweak corrections upon using the double-pole approximation and the effective vector-boson approximation along with leading-logarithmic corrections.

The transcriptome of Bathymodiolus azoricus gill reveals expression of genes from endosymbionts and free-living deep-sea bacteria.

PubMed

Egas, Conceição; Pinheiro, Miguel; Gomes, Paula; Barroso, Cristina; Bettencourt, Raul

2012-08-01

Deep-sea environments are largely unexplored habitats where a surprising number of species may be found in large communities, thriving regardless of the darkness, extreme cold, and high pressure. Their unique geochemical features result in reducing environments rich in methane and sulfides, sustaining complex chemosynthetic ecosystems that represent one of the most surprising findings in oceans in the last 40 years. The deep-sea Lucky Strike hydrothermal vent field, located in the Mid Atlantic Ridge, is home to large vent mussel communities where Bathymodiolus azoricus represents the dominant faunal biomass, owing its survival to symbiotic associations with methylotrophic or methanotrophic and thiotrophic bacteria. The recent transcriptome sequencing and analysis of gill tissues from B. azoricus revealed a number of genes of bacterial origin, hereby analyzed to provide a functional insight into the gill microbial community. The transcripts supported a metabolically active microbiome and a variety of mechanisms and pathways, evidencing also the sulfur and methane metabolisms. Taxonomic affiliation of transcripts and 16S rRNA community profiling revealed a microbial community dominated by thiotrophic and methanotrophic endosymbionts of B. azoricus and the presence of a Sulfurovum-like epsilonbacterium.

Portion size me: plate-size induced consumption norms and win-win solutions for reducing food intake and waste.

PubMed

Wansink, Brian; van Ittersum, Koert

2013-12-01

Research on the self-serving of food has empirically ignored the role that visual consumption norms play in determining how much food we serve on different sized dinnerware. We contend that dinnerware provides a visual anchor of an appropriate fill-level, which in turn, serves as a consumption norm (Study 1). The trouble with these dinnerware-suggested consumption norms is that they vary directly with dinnerware size--Study 2 shows Chinese buffet diners with large plates served 52% more, ate 45% more, and wasted 135% more food than those with smaller plates. Moreover, education does not appear effective in reducing such biases. Even a 60-min, interactive, multimedia warning on the dangers of using large plates had seemingly no impact on 209 health conference attendees, who subsequently served nearly twice as much food when given a large buffet plate 2 hr later (Study 3). These findings suggest that people may have a visual plate-fill level--perhaps 70% full--that they anchor on when determining the appropriate consumption norm and serving themselves. Study 4 suggests that the Delboeuf illusion offers an explanation why people do not fully adjust away from this fill-level anchor and continue to be biased across a large range of dishware sizes. These findings have surprisingly wide-ranging win-win implications for the welfare of consumers as well as for food service managers, restaurateurs, packaged goods managers, and public policy officials. PsycINFO Database Record (c) 2013 APA, all rights reserved.

The Negative Uses of Power

ERIC Educational Resources Information Center

Knuth, Richard

2004-01-01

Educators have at their disposal a large and substantive library of literature that defines and describes the attributes of highly effective leaders. Ashforth (1994) and Blase and Blase (2002) point out that, although volumes have been written about effective leadership, there has been surprisingly little discussion and research dedicated to…

Undoing Suggestive Influence on Memory: The Reversibility of the Eyewitness Misinformation Effect

ERIC Educational Resources Information Center

Oeberst, Aileen; Blank, Hartmut

2012-01-01

Presenting inconsistent postevent information about a witnessed incident typically decreases the accuracy of memory reports concerning that event (the "misinformation effect"). Surprisingly, the "reversibility" of the effect (after an initial occurrence) has remained largely unexplored. Based on a "memory conversion" theoretical framework and…

Gene Expression: Sizing it all up

USDA-ARS?s Scientific Manuscript database

Genomic architecture appears to be a largely unexplored component of gene expression. Although surely not the end of the story, we are learning that when it comes to gene expression, size is important. We have been surprised to find that certain patterns of expression, tissue-specific versus constit...

Recovery of Active and Efficient Photocatalytic H 2 Production for CdSe Quantum Dots

DOE PAGES

Burke, Rebeckah; Cogan, Nicole M. Briglio; Oi, Aidan; ...

2018-05-07

Recently, colloidal semiconductor quantum dots (QDs) have shown great promise as photocatalysts for the production of chemical fuels by sunlight. Here, the efficiency of photocatalytic hydrogen (H 2) production for integrated systems of large diameter (4.4 nm) CdSe QDs as light harvesting nanoparticles with varying concentrations of nickel-dihydrolipoic acid (Ni-DHLA) small molecule catalysts was measured. While exhibiting excellent robustness and longevity, the efficiency of H 2 production for equimolar catalyst and QDs was relatively poor. However, the efficiency was found to increase substantially with increasing Ni-DHLA:QD molar ratios Surprisingly, this high activity was only observed with the use of 3-mercaptopropionicmore » acid (MPA) ligands, while CdSe QDs capped with dihydrolipoic acid (DHLA) exhibited poor performance in comparison, indicating that the QD capping ligand has a substantial impact on the catalytic performance. Finally, ultrafast transient absorption spectroscopic measurements of the electron transfer (ET) dynamics show fast ET to the catalyst. Importantly, an increase in ET efficiency is observed as the catalyst concentration is increased. Together, these results suggest that for these large QDs, tailoring the QD surface environment for facile ET and increasing catalyst concentrations increases the probability of ET from QDs to Ni-DHLA, overcoming the relatively small driving force for ET and decreased surface electron density for large diameter QDs.« less

Recovery of Active and Efficient Photocatalytic H 2 Production for CdSe Quantum Dots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burke, Rebeckah; Cogan, Nicole M. Briglio; Oi, Aidan

Recently, colloidal semiconductor quantum dots (QDs) have shown great promise as photocatalysts for the production of chemical fuels by sunlight. Here, the efficiency of photocatalytic hydrogen (H 2) production for integrated systems of large diameter (4.4 nm) CdSe QDs as light harvesting nanoparticles with varying concentrations of nickel-dihydrolipoic acid (Ni-DHLA) small molecule catalysts was measured. While exhibiting excellent robustness and longevity, the efficiency of H 2 production for equimolar catalyst and QDs was relatively poor. However, the efficiency was found to increase substantially with increasing Ni-DHLA:QD molar ratios Surprisingly, this high activity was only observed with the use of 3-mercaptopropionicmore » acid (MPA) ligands, while CdSe QDs capped with dihydrolipoic acid (DHLA) exhibited poor performance in comparison, indicating that the QD capping ligand has a substantial impact on the catalytic performance. Finally, ultrafast transient absorption spectroscopic measurements of the electron transfer (ET) dynamics show fast ET to the catalyst. Importantly, an increase in ET efficiency is observed as the catalyst concentration is increased. Together, these results suggest that for these large QDs, tailoring the QD surface environment for facile ET and increasing catalyst concentrations increases the probability of ET from QDs to Ni-DHLA, overcoming the relatively small driving force for ET and decreased surface electron density for large diameter QDs.« less

OCEAN CIRCULATION. Observing the Atlantic Meridional Overturning Circulation yields a decade of inevitable surprises.

PubMed

Srokosz, M A; Bryden, H L

2015-06-19

The importance of the Atlantic Meridional Overturning Circulation (AMOC) heat transport for climate is well acknowledged. Climate models predict that the AMOC will slow down under global warming, with substantial impacts, but measurements of ocean circulation have been inadequate to evaluate these predictions. Observations over the past decade have changed that situation, providing a detailed picture of variations in the AMOC. These observations reveal a surprising degree of AMOC variability in terms of the intraannual range, the amplitude and phase of the seasonal cycle, the interannual changes in strength affecting the ocean heat content, and the decline of the AMOC over the decade, both of the latter two exceeding the variations seen in climate models. Copyright © 2015, American Association for the Advancement of Science.

Impact of oil-based drill mud disposal on benthic foraminiferal assemblages on the continental margin off Angola

NASA Astrophysics Data System (ADS)

Jorissen, F. J.; Bicchi, E.; Duchemin, G.; Durrieu, J.; Galgani, F.; Cazes, L.; Gaultier, M.; Camps, R.

2009-12-01

In order to assess the possible environmental impact of oily cuttings discharged during oil exploration activities, we studied the benthic foraminiferal faunas in a five-station, 4-km-long sampling transect around a cuttings disposal site at about 670 m depth offshore Angola (W Africa), where drilling activities started 1.5 years before sampling. Living (Rose Bengal stained) and dead foraminiferal faunas were sampled in March 2006. The faunal patterns mirror the spatial distribution of hydrocarbons, which are dispersed into a southeastern direction. Four different areas can be distinguished on the basis of the investigated faunal parameters (density, diversity and species composition of the living fauna, and comparison with subrecent dead faunas). The fauna at station S31, 300 m SE of the oil cuttings disposal site, appears to be clearly impacted: the faunal density and diversity are maximal, but evenness is minimal. Taxa sensitive to organic enrichment, such as Uvigerina peregrina, Cancris auriculus and Cribrostomoides subglobosus, have largely disappeared, whereas the low-oxygen-resistant taxon Chilostomella oolina and opportunistic buliminids and bolivinids attain relatively high densities. At station S32, 500 m SE of the disposal site, environmental impact is still perceptible. The faunal density is slightly increased, and U. peregrina, apparently the most sensitive species, is still almost absent. The faunas found at 1 and 1.8 km SE of the disposal site are apparently no longer impacted by the drill mud disposal. Faunal density and diversity are low, and the faunal composition is typical for a mesotrophic to eutrophic upper slope environment. Finally, Station S35, 2 km NW of the disposal site, contains an intermediate fauna, where both the low-oxygen-resistant C. oolina and the more sensitive taxa ( U. peregrina, C. auriculus and C. subglobosus) are present. All taxa live close to the sediment-water interface here, indicating a reduced oxygen penetration into the sediment. Since the hydrocarbon concentration is low at this station, it appears that the faunal characteristics are the consequence of a slightly different environmental setting, and not due to a contamination with drill cuttings. Our data underline the large potential of benthic foraminifera as bio-indicators of anthropogenic enrichment in open marine settings, such as caused by the disposal of oily drill cuttings. The foraminiferal faunas react essentially by a density increase of a number of tolerant and/or opportunistic taxa, and a progressive disappearance of more sensitive taxa in the most impacted area. Rather surprisingly, large-sized taxa appear to be more sensitive than small-sized foraminiferal taxa.

Spatiotemporal patterns of non-genetically modified crops in the era of expansion of genetically modified food

PubMed Central

Sun, Jing; Wu, Wenbin; Tang, Huajun; Liu, Jianguo

2015-01-01

Despite heated debates over the safety of genetically modified (GM) food, GM crops have been expanding rapidly. Much research has focused on the expansion of GM crops. However, the spatiotemporal dynamics of non-genetically modified (non-GM) crops are not clear, although they may have significant environmental and agronomic impacts and important policy implications. To understand the dynamics of non-GM crops and to inform the debates among relevant stakeholders, we conducted spatiotemporal analyses of China’s major non-GM soybean production region, the Heilongjiang Province. Even though the total soybean planting area decreased from 2005 to 2010, surprisingly, there were hotspots of increase. The results also showed hotspots of loss as well as a large decline in the number and continuity of soybean plots. Since China is the largest non-GM soybean producer in the world, the decline of its major production region may signal the continual decline of global non-GM soybeans. PMID:26380899

Lift-enhancement in the gliding paradise tree snake

NASA Astrophysics Data System (ADS)

Krishnan, Anush; Barba, Lorena A.

2012-11-01

The paradise tree snake is a good glider, despite having no wing-like appendages. This snake jumps from tree branches, flattens its body and adopts an S-shape, then glides while undulating laterally in the air. Previous experimental studies in wind and water tunnels showed that the lift of the snake cross-section can peak markedly at about 35° angle of attack, a surprising feature that hints at a lift-enhancing mechanism. Here, we report numerical simulations on the snake cross-section using an immersed boundary method, which also show the peak in lift above a certain Reynolds number threshold. Our visualizations reveal a change in the vortex shedding pattern at that angle of attack. We also study variants of the cross-section, removing the anatomical overhanging lips on the fore and aft, and observe that they have a large impact on the flow field. The best performance is in fact obtained with the anatomically correct shape of the snake.

Surviving at Any Cost: Guilt Expression Following Extreme Ethical Conflicts in a Virtual Setting

PubMed Central

Cristofari, Cécile; Guitton, Matthieu J.

2014-01-01

Studying human behavior in response to large-scale catastrophic events, particularly how moral challenges would be undertaken under extreme conditions, is an important preoccupation for contemporary scientists and decision leaders. However, researching this issue was hindered by the lack of readily available models. Immersive virtual worlds could represent a solution, by providing ways to test human behavior in controlled life-threatening situations. Using a massively multi-player zombie apocalypse setting, we analysed spontaneously reported feelings of guilt following ethically questionable actions related to survival. The occurrence and magnitude of guilt depended on the nature of the consequences of the action. Furthermore, feelings of guilt predicted long-lasting changes in behavior, displayed as compensatory actions. Finally, actions inflicting immediate harm to others appeared mostly prompted by panic and were more commonly regretted. Thus, extreme conditions trigger a reduction of the impact of ethical norms in decision making, although awareness of ethicality is retained to a surprising extent. PMID:25007261

Surviving at any cost: guilt expression following extreme ethical conflicts in a virtual setting.

PubMed

Cristofari, Cécile; Guitton, Matthieu J

2014-01-01

Studying human behavior in response to large-scale catastrophic events, particularly how moral challenges would be undertaken under extreme conditions, is an important preoccupation for contemporary scientists and decision leaders. However, researching this issue was hindered by the lack of readily available models. Immersive virtual worlds could represent a solution, by providing ways to test human behavior in controlled life-threatening situations. Using a massively multi-player zombie apocalypse setting, we analysed spontaneously reported feelings of guilt following ethically questionable actions related to survival. The occurrence and magnitude of guilt depended on the nature of the consequences of the action. Furthermore, feelings of guilt predicted long-lasting changes in behavior, displayed as compensatory actions. Finally, actions inflicting immediate harm to others appeared mostly prompted by panic and were more commonly regretted. Thus, extreme conditions trigger a reduction of the impact of ethical norms in decision making, although awareness of ethicality is retained to a surprising extent.

The impact of analogies on creative concept generation: lessons from an in vivo study in engineering design.

PubMed

Chan, Joel; Schunn, Christian

2015-01-01

Research on innovation often highlights analogies from sources outside the current problem domain as a major source of novel concepts; however, the mechanisms underlying this relationship are not well understood. We analyzed the temporal interplay between far analogy use and creative concept generation in a professional design team's brainstorming conversations, investigating the hypothesis that far analogies lead directly to very novel concepts via large steps in conceptual spaces (jumps). Surprisingly, we found that concepts were more similar to their preceding concepts after far analogy use compared to baseline situations (i.e., without far analogy use). Yet far analogies increased the team's concept generation rate compared to baseline conditions. Overall, these results challenge the view that far analogies primarily lead to novel concepts via jumps in conceptual spaces and suggest alternative pathways from far analogies to novel concepts (e.g., iterative, deep exploration within a functional space). Copyright © 2014 Cognitive Science Society, Inc.

Microglial Dysfunction in Brain Aging and Alzheimer’s Disease

PubMed Central

Mosher, Kira Irving; Wyss-Coray, Tony

2014-01-01

Microglia, the immune cells of the central nervous system, have long been a subject of study in the Alzheimer’s disease (AD) field due to their dramatic responses to the pathophysiology of the disease. With several large-scale genetic studies in the past year implicating microglial molecules in AD, the potential significance of these cells has become more prominent than ever before. As a disease that is tightly linked to aging, it is perhaps not entirely surprising that microglia of the AD brain share some phenotypes with aging microglia. Yet the relative impacts of both conditions on microglia are less frequently considered in concert. Furthermore, microglial “activation” and “neuroinflammation” are commonly analyzed in studies of neurodegeneration but are somewhat ill-defined concepts that in fact encompass multiple cellular processes. In this review, we have enumerated six distinct functions of microglia and discuss the specific effects of both aging and AD. By calling attention to the commonalities of these two states, we hope to inspire new approaches for dissecting microglial mechanisms. PMID:24445162

Is Perineural Invasion of Head and Neck Squamous Cell Carcinomas Linked to Tobacco Consumption?

PubMed

Baumeister, Philipp; Welz, Christian; Jacobi, Christian; Reiter, Maximilian

2018-05-01

Perineural invasion (PNI) is an underrecognized path of cancer spread, and its causes and mechanisms are poorly understood. Recent research indicates a mutual attraction of neuronal and cancer cells, largely dependent on neurotrophic factors and their receptors. Interestingly, the release of neurotrophic factors occurs upon cigarette smoke/nicotine exposure in a dose-dependent manner, and serum levels correlate with current smoking, number of smoking years, and smoking severity. Among cell types capable of neurotrophic factors secretion are lung and oral fibroblasts. In our study of 178 patients with head and neck squamous cell carcinoma, tumors of current and former smokers showed PNI significantly more often than tumors of never smokers. Moreover, PNI was a marker for aggressive tumor growth. Surprisingly, PNI was more significant for survival than p16 status. Our study warrants further research on PNI in head and neck squamous cell carcinoma with special emphasis on the impact of tobacco consumption to identify suitable candidates for therapeutic interventions.

Debris ingestion by juvenile marine turtles: an underestimated problem.

PubMed

Santos, Robson Guimarães; Andrades, Ryan; Boldrini, Marcillo Altoé; Martins, Agnaldo Silva

2015-04-15

Marine turtles are an iconic group of endangered animals threatened by debris ingestion. However, key aspects related to debris ingestion are still poorly known, including its effects on mortality and the original use of the ingested debris. Therefore, we analysed the impact of debris ingestion in 265 green turtles (Chelonia mydas) over a large geographical area and different habitats along the Brazilian coast. We determined the death rate due to debris ingestion and quantified the amount of debris that is sufficient to cause the death of juvenile green turtles. Additionally, we investigated the original use of the ingested debris. We found that a surprisingly small amount of debris was sufficient to block the digestive tract and cause death. We suggested that debris ingestion has a high death potential that may be masked by other causes of death. An expressive part of the ingested debris come from disposable and short-lived products. Copyright © 2015 Elsevier Ltd. All rights reserved.

Spatiotemporal patterns of non-genetically modified crops in the era of expansion of genetically modified food.

PubMed

Sun, Jing; Wu, Wenbin; Tang, Huajun; Liu, Jianguo

2015-09-18

Despite heated debates over the safety of genetically modified (GM) food, GM crops have been expanding rapidly. Much research has focused on the expansion of GM crops. However, the spatiotemporal dynamics of non-genetically modified (non-GM) crops are not clear, although they may have significant environmental and agronomic impacts and important policy implications. To understand the dynamics of non-GM crops and to inform the debates among relevant stakeholders, we conducted spatiotemporal analyses of China's major non-GM soybean production region, the Heilongjiang Province. Even though the total soybean planting area decreased from 2005 to 2010, surprisingly, there were hotspots of increase. The results also showed hotspots of loss as well as a large decline in the number and continuity of soybean plots. Since China is the largest non-GM soybean producer in the world, the decline of its major production region may signal the continual decline of global non-GM soybeans.

Characterizing a scientific elite: the social characteristics of the most highly cited scientists in environmental science and ecology.

PubMed

Parker, John N; Lortie, Christopher; Allesina, Stefano

2010-10-01

In science, a relatively small pool of researchers garners a disproportionally large number of citations. Still, very little is known about the social characteristics of highly cited scientists. This is unfortunate as these researchers wield a disproportional impact on their fields, and the study of highly cited scientists can enhance our understanding of the conditions which foster highly cited work, the systematic social inequalities which exist in science, and scientific careers more generally. This study provides information on this understudied subject by examining the social characteristics and opinions of the 0.1% most cited environmental scientists and ecologists. Overall, the social characteristics of these researchers tend to reflect broader patterns of inequality in the global scientific community. However, while the social characteristics of these researchers mirror those of other scientific elites in important ways, they differ in others, revealing findings which are both novel and surprising, perhaps indicating multiple pathways to becoming highly cited.

Characterizing a scientific elite: the social characteristics of the most highly cited scientists in environmental science and ecology

PubMed Central

Lortie, Christopher; Allesina, Stefano

2010-01-01

In science, a relatively small pool of researchers garners a disproportionally large number of citations. Still, very little is known about the social characteristics of highly cited scientists. This is unfortunate as these researchers wield a disproportional impact on their fields, and the study of highly cited scientists can enhance our understanding of the conditions which foster highly cited work, the systematic social inequalities which exist in science, and scientific careers more generally. This study provides information on this understudied subject by examining the social characteristics and opinions of the 0.1% most cited environmental scientists and ecologists. Overall, the social characteristics of these researchers tend to reflect broader patterns of inequality in the global scientific community. However, while the social characteristics of these researchers mirror those of other scientific elites in important ways, they differ in others, revealing findings which are both novel and surprising, perhaps indicating multiple pathways to becoming highly cited. PMID:20927183

Aeolian comminution experiments revealing surprising sandball mineral aggregates

NASA Astrophysics Data System (ADS)

Nørnberg, P.; Bak, E.; Finster, K.; Gunnlaugsson, H. P.; Iversen, J. J.; Jensen, S. Knak; Merrison, J. P.

2014-06-01

We have undertaken a set of wind erosion experiments on a simple and well defined mineral, quartz. In these experiments wind action is simulated by end over end tumbling of quartz grains in a sealed quartz flask. The tumbling induces collisions among the quartz grains and the walls of the flask. This process simulates wind action impact speed of ∼1.2 m/s. After several months of tumbling we observed the formation of a large number of spherical sand aggregates, which resemble small snowballs under optical microscopy. Upon mechanical load the aggregates are seen to be more elastic than quartz and their mechanical strength is comparable, though slightly lower than that of sintered silica aerogels. Aggregates of this kind have not been reported from field sites or from closed circulation systems. However, sparse occurrence might explain this, or in nature the concentration of the aggregate building particles is so low that they never meet and just appear as the most fine grained tail of the sediment particle size distribution.

Stable CoT-1 repeat RNA is abundant and associated with euchromatic interphase chromosomes

PubMed Central

Hall, Lisa L.; Carone, Dawn M.; Gomez, Alvin; Kolpa, Heather J.; Byron, Meg; Mehta, Nitish; Fackelmayer, Frank O.; Lawrence, Jeanne B.

2014-01-01

SUMMARY Recent studies recognize a vast diversity of non-coding RNAs with largely unknown functions, but few have examined interspersed repeat sequences, which constitute almost half our genome. RNA hybridization in situ using CoT-1 (highly repeated) DNA probes detects surprisingly abundant euchromatin-associated RNA comprised predominantly of repeat sequences (“CoT-1 RNA”), including LINE-1. CoT-1-hybridizing RNA strictly localizes to the interphase chromosome territory in cis, and remains stably associated with the chromosome territory following prolonged transcriptional inhibition. The CoT-1 RNA territory resists mechanical disruption and fractionates with the non-chromatin scaffold, but can be experimentally released. Loss of repeat-rich, stable nuclear RNAs from euchromatin corresponds to aberrant chromatin distribution and condensation. CoT-1 RNA has several properties similar to XIST chromosomal RNA, but is excluded from chromatin condensed by XIST. These findings impact two “black boxes” of genome science: the poorly understood diversity of non-coding RNA and the unexplained abundance of repetitive elements. PMID:24581492

Extent and Effectiveness of Coral Reef Marine Protected Areas for a Ubiquitous Mesopredator, Bluefin Trevally (Caranx melampygus)

NASA Astrophysics Data System (ADS)

Del Raye, G.; Weng, K.

2012-12-01

An urgent challenge facing global marine fisheries is the zoning and implementation of marine protected areas (MPAs). Effective zoning of MPAs requires detailed knowledge of the movement patterns and habitat usage of the species to be protected, yet this information is deficient for many coral reef fishes. We use new detailed acoustic tracking and habitat usage data for a ubiquitous coral reef predator - Caranx melampygus - to understand how well existing MPAs protect this highly fished stock. Surprisingly, our data show that as little as 12% of the MPAs existing within the distribution of C. melampygus are large enough to encompass the movement range of even a single adult individual, suggesting that the establishment of larger coral reef MPAs will be crucial for the sustainable harvesting of this species. These results underscore the urgency of obtaining tracking data for other important coral reef species to better understand the impact of current and planned MPAs on their fisheries.

Impact of Site Elevation on Mg Smelter Design

NASA Astrophysics Data System (ADS)

Baker, Phillip W.

Site elevation has many surprising and significant impacts on the engineering design of metallurgical plant of all types. Electrolytic magnesium smelters maybe built at high elevation for a variety of reasons including availability of raw material, energy or electric power. Because of the unit processes they typically involve, Mg smelters can be extensively impacted by site elevation. In this paper, generic examples of the design changes required to adapt a smelter originally designed for sea level to operate at 2700 m are presented. While the examples are drawn from a magnesium plant design case, these changes are generically applicable to all industrial plants utilizing similar unit processes irrespective of product.

Choosing a College. Minnesota 2014-15

ERIC Educational Resources Information Center

Minnesota Office of Higher Education, 2014

2014-01-01

Minnesota is home to some of the finest postsecondary institutions in the country. From campuses large to small, urban to rural, close to home or far away, the state's public and private colleges and universities offer a broad spectrum of surprising educational opportunities and experiences. This guide can help students explore Minnesota College…

Methods for separation/purification utilizing rapidly cycled thermal swing sorption

DOEpatents

Tonkovich, Anna Lee Y.; Monzyk, Bruce F.; Wang, Yong; VanderWiel, David P.; Perry, Steven T.; Fitzgerald, Sean P.; Simmons, Wayne W.; McDaniel, Jeffrey S.; Weller, Jr., Albert E.

2004-11-09

The present invention provides apparatus and methods for separating fluid components. In preferred embodiments, the apparatus and methods utilize microchannel devices with small distances for heat and mass transfer to achieve rapid cycle times and surprisingly large volumes of fluid components separated in short times using relatively compact hardware.

BY HOW MUCH DO SHAPES OF TOXICOLOGICAL DOSE-RESPONSE RELATIONSHIPS VARY? (SOT)

EPA Science Inventory

A re-analysis of a large number of historical dose-response data for continuous endpoints showed that the shapes of the dose-response relationships were surprisingly homogenous. The datasets were selected on the sole criterion that they were expected to provide relatively good in...

Preserving Marine Corps Forcible Entry in the 21st Century: Possible or Preposterous?

DTIC Science & Technology

2011-03-30

expanded their territorial control in ·southeast Asia . After a virtmilly unchecked advance through the Philippines, the Indies, ci large . portion...commanders may select one . ’ method or a ~ombination of entry capabilities to achieve surprise, initiative, and tempo. As MCD ? 3, Expeditionary

Television viewing and physical activity among Latino children

USDA-ARS?s Scientific Manuscript database

Watching television and using other forms of media such as video games, computers, print, music and movies takes up a surprisingly large amount of our children’s time. U.S. children spend more time watching television than any other activity except sleep. According to a recent nationwide report on c...

Does Mood Change How We Organize Digital Files?

ERIC Educational Resources Information Center

Massey, Charlotte

2017-01-01

Retrieving files from one's computer is done daily and is an essential part of completing most tasks at work, yet surprisingly little research has examined the ways that people structure and organize their files. Management of personal digital information is a challenging task that users approach idiosyncratically. Large individual differences…

Exploiting Large-Scale Drug-Protein Interaction Information for Computational Drug Repurposing

DTIC Science & Technology

2014-06-20

other anti- HIV drugs, even though it is not approved as a mono- therapy for HIV. Surprisingly, two statins, atorvastatin and lovastatin, scored among...infected persons. Amprenavir 19.6 For treatment of HIV-1 infection in combination with other antiretroviral agents. Atorvastatin 19.3 For

Measuring Understanding of Nanoscience and Nanotechnology: Development and Validation of the Nano-Knowledge Instrument (NanoKI)

ERIC Educational Resources Information Center

Schönborn, K. J.; Höst, G. E.; Lundin Palmerius, K. E.

2015-01-01

As the application of nanotechnology in everyday life impacts society, it becomes critical for citizens to have a scientific basis upon which to judge their perceived hopes and fears of 'nano'. Although multiple instruments have been designed for assessing attitudinal and affective aspects of nano, surprisingly little work has focused on…

A phylogenomic analysis of Marek’s disease virus (MDV) reveals independent paths to virulence in Eurasia and North America

USDA-ARS?s Scientific Manuscript database

Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of many pathogens is surprisingly incomplete. Here, we explore the evolution of Marek’s disease virus (MDV), a herpesvirus commonly afflicting chic...

Evaluating the Impact of Intimate Partner Violence on the Perpetrator: The Perceived Consequences of Domestic Violence Questionnaire

ERIC Educational Resources Information Center

Walker, Denise D.; Neighbors, Clayton; Mbilinyi, Lyungai F.; O'Rourke, Allison; Zegree, Joan; Roffman, Roger A.; Edleson, Jeffrey L.

2010-01-01

Surprisingly, little is known about how IPV perpetrators perceive the consequences of their violent behavior. This article describes the development and evaluation of the Perceived Consequences of Domestic Violence Questionnaire (PCDVQ). The PCDVQ is a 27 item self report instrument designed to assess the consequences of intimate partner violence…

Adults with Intellectual Disabilities: Prevalence, Incidence and Remission of Aggressive Behaviour and Related Factors

ERIC Educational Resources Information Center

Cooper, S.-A.; Smiley, E.; Jackson, A.; Finlayson, J.; Allan, L.; Mantry, D.; Morrison, J.

2009-01-01

Introduction: Aggressive behaviours can be disabling for adults with intellectual disabilities (ID), with negative consequences for the adult, their family and paid carers. It is surprising how little research has been conducted into the epidemiology of these needs, given the impact they can have. This study investigates point prevalence, 2-year…

Strengthening environmental foresight: potential contributions of futures research

Treesearch

David N. Bengston; George H. Kubik; Peter C. Bishop

2012-01-01

The need for environmental foresight has increased in recent decades as the pace of change has accelerated and the frequency of surprise has increased. Successfully dealing with the growing impacts of change on social-ecological systems depends on our ability to anticipate change. But traditional scientific tools are blunt instruments for studying a future that does...

Bounded Rationality, Emotions and Older Adult Decision Making: Not so Fast and yet so Frugal

ERIC Educational Resources Information Center

Hanoch, Yaniv; Wood, Stacey; Rice, Thomas

2007-01-01

Herbert Simon's work on bounded rationality has had little impact on researchers studying older adults' decision making. This omission is surprising, as human constraints on computation and memory are exacerbated in older adults. The study of older adults' decision-making processes could benefit from employing a bounded rationality perspective,…

The Impact of Service-Learning among Other Predictors for Persistence and Degree Completion of Undergraduate Students

ERIC Educational Resources Information Center

Lockeman, Kelly Smith

2012-01-01

College completion is an issue of great concern in the United States, where only 50% of students who start college as freshmen complete a bachelor's degree at that institution within six years. Researchers have studied a variety of factors to understand their relationship to student persistence. Not surprisingly, student characteristics,…

Benefits of Omega-3 Supplementation for Schoolchildren: Review of the Current Evidence

ERIC Educational Resources Information Center

Kirby, Amanda; Woodward, Amelia; Jackson, Sarah

2010-01-01

Despite the potential impact nutrition may have on learning, there have been surprisingly few papers published directed towards the educational research community. In contrast, omega-3 supplementation studies are being frequently cited in the media, leading to parents asking for advice and guidance. The purpose of this article is to review the…

Exploring the Relationships between the Use of Text Message Language and the Literacy Skills of Dyslexic and Normal Students

ERIC Educational Resources Information Center

Hsu, Jung-Lung

2013-01-01

It is apparent that individuals using text abbreviations as a written convention is a continuingly growing phenomenon. This special writing convention has been referred to as textism usage. However, there is surprisingly little research investigating the impacts of textism use on dyslexic children's cognitive abilities associated with literacy…

Hillslope erosion rates in the oak savannas of the southwestern borderlands region

Treesearch

Aaron T. Kauffman; Cody L. Stropki; Peter F. Ffolliott; Gerald J. Gottfried; Daniel G. Neary

2007-01-01

Hillslope soil erosion on watershed landscapes can lower the productivity of upland sites and adversely impact water quality and downstream (off-site) areas. It is not surprising, therefore, that excessive soil erosion and the consequent sedimentation can represent significant costs to the land and people that are affected. The first known estimates of hillslope soil...

The Impact of Acquisition Issues and Training on Test and Evaluation

DTIC Science & Technology

2000-01-01

feedback on the OT results before a milestone review and then delivering the OT report, with surprises, virtually at the review. Test Realism There...of the R3D/100 Chip Set and Simulation Heritage. MLRS WE’RE IN THE ARMY NOW TE 14(1 Video, 15 Mins) Cinematics - LTV Aerospace & Defense

The Why, What, and How of Reviewer Education: A Human Capital Approach

ERIC Educational Resources Information Center

Sullivan, Sherry E.; Baruch, Yehuda; Schepmyer, Hazlon

2010-01-01

Reviewing has long been recognized as a critical part of the academic process of knowledge creation, development, and dissemination. However, as evidenced by recent findings from focus groups and an international survey, the relative lack of effective formal training in management PhD programs on how to review is surprising given the impact that…

Constructions of Local Culture and Impacts on Domestic Violence in an Australian Rural Community

ERIC Educational Resources Information Center

Wendt, Sarah

2009-01-01

Studies of domestic violence in rural areas have predominantly focused on barriers that keep women trapped in abusive relationships. The literature has frequently suggested that rural culture influences the incidence of domestic violence, the forms it takes, and how it is experienced. Yet there is surprisingly little research on how rural culture…

Grinding the Antitesting Ax: More Bias than Evidence behind NRC Panel's Conclusions

ERIC Educational Resources Information Center

Hanushek, Eric A.

2012-01-01

In all the acrimonious discussion surrounding No Child Left Behind Act of 2001 (NCLB), surprisingly little attention has been given to the actual impact of that legislation and other accountability systems on student performance. Now a reputable body, a committee set up by the National Research Council (NRC), the research arm of the National…

Perspectives on the Impact of Varicella Immunization on Herpes Zoster. A Model-Based Evaluation from Three European Countries

PubMed Central

Poletti, Piero; Melegaro, Alessia; Ajelli, Marco; del Fava, Emanuele; Guzzetta, Giorgio; Faustini, Luca; Scalia Tomba, Giampaolo; Lopalco, Pierluigi; Rizzo, Caterina; Merler, Stefano; Manfredi, Piero

2013-01-01

The introduction of mass vaccination against Varicella-Zoster-Virus (VZV) is being delayed in many European countries because of, among other factors, the possibility of a large increase in Herpes Zoster (HZ) incidence in the first decades after the initiation of vaccination, due to the expected decline of the boosting of Cell Mediated Immunity caused by the reduced varicella circulation. A multi-country model of VZV transmission and reactivation, is used to evaluate the possible impact of varicella vaccination on HZ epidemiology in Italy, Finland and the UK. Despite the large uncertainty surrounding HZ and vaccine-related parameters, surprisingly robust medium-term predictions are provided, indicating that an increase in HZ incidence is likely to occur in countries where the incidence rate is lower in absence of immunization, possibly due to a higher force of boosting (e.g. Finland), whereas increases in HZ incidence might be minor where the force of boosting is milder (e.g. the UK). Moreover, a convergence of HZ post vaccination incidence levels in the examined countries is predicted despite different initial degrees of success of immunization policies. Unlike previous model-based evaluations, our investigation shows that after varicella immunization an increase of HZ incidence is not a certain fact, rather depends on the presence or absence of factors promoting a strong boosting intensity and which might or not be heavily affected by changes in varicella circulation due to mass immunization. These findings might explain the opposed empirical evidences observed about the increases of HZ in sites where mass varicella vaccination is ongoing. PMID:23613740

Eta Lyrids (ELY-145)

NASA Astrophysics Data System (ADS)

Roggemans, Paul; Cambell-Burns, Peter

2018-03-01

Two years in a row the eta Lyrids (#145-ELY) caught the attention of the CAMS BeNeLux camera network with surprisingly large numbers of orbits collected for this stream. An independent search was made on the data of 686000 public available video meteor orbits. The results confirm earlier studies with a clear activity profile between solar longitude 45° and 53° with a sharp peak at 49.5±0.2°. No mention of this shower could be found before the passage of the parent comet C/1983 H1 (IRAS-Araki-Alcock) in 1983. In recent years the shower tends to surprise observers with some low but distinct activity. Outbursts are not excluded in the future, observers are recommended to keep an eye on this shower.

Lightning Mapping Observations During DC3 in Northern Colorado

NASA Astrophysics Data System (ADS)

Krehbiel, P. R.; Rison, W.; Thomas, R. J.

2012-12-01

The Deep Convective Clouds and Chemistry Experiment (DC3) was conducted in three regions covered by Lightning Mapping Arrays (LMAs): Oklahoma and west Texas, northern Alabama, and northern Colorado. In this and a companion presentation, we discuss results obtained from the newly-deployed North Colorado LMA. The CO LMA revealed a surprising variety of lightning-inferred electrical structures, ranging from classic tripolar, normal polarity storms to several variations of anomalously electrified systems. Storms were often characterized by a pronounced lack or deficit of cloud-to-ground discharges (negative or positive), both in relative and absolute terms compared to the large amount of intracloud activity revealed by the LMA. Anomalous electrification was observed in small, localized storms as well as in large, deeply convective and severe storms. Another surprising observation was the frequent occurrence of embedded convection in the downwind anvil/outflow region of large storm systems. Observations of discharges in low flash rate situations over or near the network are sufficiently detailed to enable branching algorithms to estimate total channel lengths for modeling NOx production. However, this will not be possible in large or distant storm systems where the lightning was essentially continuous and structurally complex, or spatially noisy. Rather, a simple empirical metric for characterizing the lightning activity can be developed based on the number of located VHF radiation sources, weighted for example by the peak source power, source altitude, and temporal duration.

Nonconsumptive Effects of Predatory Chrysomya rufifacies (Diptera: Calliphoridae) Larval Cues on Larval Cochliomyia macellaria (Diptera: Calliphoridae) Growth and Development.

PubMed

Flores, Micah; Crippen, Tawni L; Longnecker, Michael; Tomberlin, Jeffery K

2017-09-01

Forensic entomologists often rely on development data associated with a given species to estimate when it colonized human or other vertebrate remains. In most instances, these development studies are based on single species reared in isolation in the laboratory. This study examined the impact of excretions and secretions (ES) associated with third-instar Chrysomya rufifacies (Macquart), a predator, on the development of its prey, Cochliomyia macellaria (F.). Not surprisingly, Ch. rufifacies ES did not impact the development of first- or second-instar C. macellaria, which are typically not preyed on by Ch. rufifacies. However, development of third-instar C. macellaria, which do experience predation, was impacted. First, larvae were longer than those in the control (deionized water, dH2O). Filtering the ES and removing the associated bacteria and byproducts >0.2 µm dampened the previous impact observed by the unfiltered ES on third-instar C. macellaria. Second, third-instar C. macellaria treated with unfiltered ES completed pupariation 8 h quicker than the controls. Filtering the ES lessened this effect by 50%. And finally, third-instar C. macellaria treated with filtered or unfiltered Ch. rufifacies ES reached adulthood ∼5 h faster than controls treated with dH2O. In summary, these data have large ramifications for forensic entomology, as multiple species being present on decomposing remains is not uncommon. Understanding the impact of associated ES produced by interspecific cohorts on associated development could lead to more precise estimates of the minimum postmortem interval for forensic investigation of decomposing remains. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Numerical Simulations of Silverpit Crater Collapse

NASA Technical Reports Server (NTRS)

Collins, G. S.; Turtle, E. P.; Melosh, H. J.

2003-01-01

The Silverpit crater is a recently discovered, 60-65 Myr old complex crater, which lies buried beneath the North Sea, about 150 km east of Britain. High-resolution images of Silverpit's subsurface structure, provided by three-dimensional seismic reflection data, reveal an inner-crater morphology similar to that expected for a 5-8 km diameter terrestrial crater. The crater walls show evidence of terracestyle slumping and there is a distinct central uplift, which may have produced a central peak in the pristine crater morphology. However, Silverpit is not a typical 5-km diameter terrestrial crater, because it exhibits multiple, concentric rings outside the main cavity. External concentric rings are normally associated with much larger impact structures, for example Chicxulub on Earth, or Orientale on the Moon. Furthermore, external rings associated with large impacts on the terrestrial planets and moons are widely-spaced, predominantly inwardly-facing, asymmetric scarps. However, the seismic data show that the external rings at Silverpit represent closely-spaced, concentric fault-bound graben, with both inwardly and outwardly facing faults-carps. This type of multi-ring structure is directly analogous to the Valhalla-type multi-ring basins found on the icy satellites. Thus, the presence and style of the multiple rings at Silverpit is surprising given both the size of the crater and its planetary setting.

Continent of pessimism or continent of realism? A multilevel study into the impact of macro-economic outcomes and political institutions on societal pessimism, European Union 2006-2012.

PubMed

Steenvoorden, Eefje H; van der Meer, Tom Wg

2017-06-01

The often-posed claim that Europe is a pessimistic continent is not unjustified. In 2012, 53 percent of European Union (EU) citizens were pessimistic about their country. Surprisingly, however, societal pessimism has received very little scientific attention. In this article, we examine to what extent political and economic factors drive societal pessimism. In terms of political factors, we expect that supranationalization, political instability, and corruption increase societal pessimism, as they diminish national political power and can inspire collective powerlessness. Economically, we expect that the retrenchment of welfare state provisions and economic decline drive societal pessimism, as these developments contribute to socioeconomic vulnerability. We assess the impact of these political and economic factors on the level of societal pessimism in the EU, both cross-nationally and over time, through multilevel analyses of Eurobarometer data (13 waves between 2006 and 2012 in 23 EU countries). Our findings show that the political factors (changes in government, corruption) primarily explain cross-national differences in societal pessimism, while the macro-economic context (economic growth, unemployment) primarily explains longitudinal trends within countries. These findings demonstrate that, to a large extent, societal pessimism cannot be viewed separately from its political and economic context.

Continent of pessimism or continent of realism? A multilevel study into the impact of macro-economic outcomes and political institutions on societal pessimism, European Union 2006–2012

PubMed Central

Steenvoorden, Eefje H; van der Meer, Tom WG

2017-01-01

The often-posed claim that Europe is a pessimistic continent is not unjustified. In 2012, 53 percent of European Union (EU) citizens were pessimistic about their country. Surprisingly, however, societal pessimism has received very little scientific attention. In this article, we examine to what extent political and economic factors drive societal pessimism. In terms of political factors, we expect that supranationalization, political instability, and corruption increase societal pessimism, as they diminish national political power and can inspire collective powerlessness. Economically, we expect that the retrenchment of welfare state provisions and economic decline drive societal pessimism, as these developments contribute to socioeconomic vulnerability. We assess the impact of these political and economic factors on the level of societal pessimism in the EU, both cross-nationally and over time, through multilevel analyses of Eurobarometer data (13 waves between 2006 and 2012 in 23 EU countries). Our findings show that the political factors (changes in government, corruption) primarily explain cross-national differences in societal pessimism, while the macro-economic context (economic growth, unemployment) primarily explains longitudinal trends within countries. These findings demonstrate that, to a large extent, societal pessimism cannot be viewed separately from its political and economic context. PMID:28690338

Long-term nutrient reductions lead to the unprecedented recovery of a temperate coastal region.

PubMed

Lefcheck, Jonathan S; Orth, Robert J; Dennison, William C; Wilcox, David J; Murphy, Rebecca R; Keisman, Jennifer; Gurbisz, Cassie; Hannam, Michael; Landry, J Brooke; Moore, Kenneth A; Patrick, Christopher J; Testa, Jeremy; Weller, Donald E; Batiuk, Richard A

2018-04-03

Humans strongly impact the dynamics of coastal systems, yet surprisingly few studies mechanistically link management of anthropogenic stressors and successful restoration of nearshore habitats over large spatial and temporal scales. Such examples are sorely needed to ensure the success of ecosystem restoration efforts worldwide. Here, we unite 30 consecutive years of watershed modeling, biogeochemical data, and comprehensive aerial surveys of Chesapeake Bay, United States to quantify the cascading effects of anthropogenic impacts on submersed aquatic vegetation (SAV), an ecologically and economically valuable habitat. We employ structural equation models to link land use change to higher nutrient loads, which in turn reduce SAV cover through multiple, independent pathways. We also show through our models that high biodiversity of SAV consistently promotes cover, an unexpected finding that corroborates emerging evidence from other terrestrial and marine systems. Due to sustained management actions that have reduced nitrogen concentrations in Chesapeake Bay by 23% since 1984, SAV has regained 17,000 ha to achieve its highest cover in almost half a century. Our study empirically demonstrates that nutrient reductions and biodiversity conservation are effective strategies to aid the successful recovery of degraded systems at regional scales, a finding which is highly relevant to the utility of environmental management programs worldwide.

The physical and psychological impact of neurogenic claudication: the patients' perspectives.

PubMed

Ammendolia, Carlo; Schneider, Michael; Williams, Kelly; Zickmund, Susan; Hamm, Megan; Stuber, Kent; Tomkins-Lane, Christy; Rampersaud, Y Raja

2017-03-01

The patient perspective regarding the impact of neurogenic claudication (NC) has not been well studied. The objectives of this study were to determine what is most bothersome among patients with NC and how it impacts their lives and expectations with surgical and non-surgical treatment. Semi-structured telephone interviews were conducted, audio recorded and transcribed verbatim. A thematic analysis categorized key findings based on relative importance and impact on participants. Twenty-eight individuals participated in this study. Participants were most bothered by the pain of NC, which dramatically impacted their lives. Inability to walk was the dominant functional limitation and this impacted the ability to engage in recreational and social activities. The most surprising finding was how frequently participants reported significant emotional effects of NC. From a patients' perspective NC has a significant multidimensional effects with pain, limited walking ability and emotional effects being most impactful to their lives.

Muhammad Ali's Fighting Words: The Paradox of Violence in Nonviolent Rhetoric

ERIC Educational Resources Information Center

Gorsevski, Ellen W.; Butterworth, Michael L.

2011-01-01

While Muhammad Ali has been the subject of countless articles and books written by sports historians and journalists, rhetorical scholars have largely ignored him. This oversight is surprising given both the tradition of social movement scholarship within rhetorical studies and Ali's influential eloquence as a world renowned celebrity espousing…

Nitric oxide production in the stratosphere within the Space Shuttle's solid rocket motor plumes

NASA Technical Reports Server (NTRS)

Gomberg, R. I.; Brannan, J. R.; Boney, L. R.

1978-01-01

This study focuses on establishing the sensitivity of predictions of NO production to uncertainties in altitude, reaction rate coefficients, turbulent mixing rates, and Mach disk size and location. The results show that relatively large variations in parameters related to these phenomena had surprisingly little effect on predicted NO production.

Business Travel | Climate Neutral Research Campuses | NREL

Science.gov Websites

evaluated for research campus climate action plans, and it can be surprisingly large. At Cornell University , for example, business air travel generated 27,000 tons of carbon dioxide in 2008, accounting for 8.5 campus. The following outlines resources and opportunities for research campuses to manage business

What Makes the Finnish Different in Science? Assessing and Comparing Students' Science Learning in Three Countries

ERIC Educational Resources Information Center

Geller, Cornelia; Neumann, Knut; Boone, William J.; Fischer, Hans E.

2014-01-01

This manuscript details our efforts to assess and compare students' learning about electricity in three countries. As our world is increasingly driven by technological advancements, the education of future citizens in science becomes one important resource for economic productivity. Not surprisingly international large-scale assessments are viewed…

Partners in Advocacy

ERIC Educational Resources Information Center

Cigale, George

2005-01-01

The surprising success of Live Homework Help, a product of Tutor.com unknown to libraries before 2001, is in very large part owing to the company's effort to understand library funding and help libraries tap into all kinds of potential funding sources. The story is a model for partnerships between other companies and libraries. For the people of…

The Element of Surprise: Preparing for the Possibility of Hazardous Materials within Archival Collections

ERIC Educational Resources Information Center

Wiener, Judith A.

2007-01-01

Unprocessed archival collections can contain unknown and potentially hazardous materials that can be harmful to other collections and staff. Archival literature largely focuses on collection and personnel dangers posed by environmental hazards such as mold and insect infestation but not on pharmaceutical and chemical hazards. In this article, the…

Sustainability in Bioscience Fieldwork: Practical Information from a UK Agricultural Research Institute

ERIC Educational Resources Information Center

Wright, Hazel A.; Ironside, Joseph E.; Gwynn-Jones, Dylan

2009-01-01

Purpose: Owing to the specialist nature of biological experimentation, scientific research staff have been largely neglected from the pro-environmental initiatives which have inundated other areas of higher education. This dearth of studies is surprising given that scientific research is recognised as a substantial contributor to the environmental…

Animal Rights and Human Growth: Intellectual Courage and Extending the Moral Community

ERIC Educational Resources Information Center

Rowe, Bradley D.

2009-01-01

While the ethical dimension of human-animal relationships has become a legitimate, rich subject for contemporary moral philosophers, scholars of moral education, and to a large extent, philosophers of education, have remained surprisingly silent on this subject. The primary purpose of this essay is to illustrate the relationship between the moral…

LJ Best of 2009 Business Books: 32 Titles

ERIC Educational Resources Information Center

Cords, Sarah Statz

2010-01-01

It should come as no surprise that a large share of this year's business books focus squarely on the 2008-09 financial crisis and security-backed mortgage implosion. Investing books followed the trend as either alarmist titles advocating selling stocks, or books urging readers to take advantage of this time to buy undervalued investments. An…

Flipping the Switch: Code-Switching from Text Speak to Standard English

ERIC Educational Resources Information Center

Turner, Kristen Hawley

2009-01-01

Because digital language represents such a large part of the primary discourse of today's adolescents, it is not surprising that the style of electronic communication is "seeping into their schoolwork." According to a recent study published by the Pew Internet and American Life Project, in partnership with the College Board's National Commission…

Using Summative and Formative Assessments to Evaluate EFL Teachers' Teaching Performance

ERIC Educational Resources Information Center

Wei, Wei

2015-01-01

Using classroom observations (formative) and student course experience survey results (summative) to evaluate English lecturers' teaching performances is not new in practice, but surprisingly only a few studies have investigated this issue in a higher education context. This study was conducted in an English department of a large university in…

Multisite Studies and Scaling up in Educational Research

ERIC Educational Resources Information Center

Harwell, Michael

2012-01-01

A scale-up study in education typically expands the sample of students, schools, districts, and/or practices or materials used in smaller studies in ways that build in heterogeneity. Yet surprisingly little is known about the factors that promote successful scaling up efforts in education, in large part due to the absence of empirically supported…

Latinas in Need

ERIC Educational Resources Information Center

Dempsey, Beth

2007-01-01

In the summer of 2006, the New York City-based Spanish-language newspaper "La Prensa" ran a series of articles on the surprisingly stressful life of the young Latina in America. The series brought to light grim statistics uncovered in the academic community that had largely escaped the mainstream. Namely, young Latinas--ages 12-17--are more likely…

Memories of Play, Dreams of Success: Literacy Autobiographies of 101 Students.

ERIC Educational Resources Information Center

Fox, Stephen L.

Despite the stereotype of today's undergraduates as having an inadequate literacy level, a teacher of English at a large midwestern university was surprised to find that students' literacy autobiographies reflect what might be called a conventional literacy success story, one that represents a strain of American autobiography dating back to…

The roles of birth inputs and outputs in predicting health, behaviour and test scores in early childhood.

PubMed

Li, Kai; Poirier, Dale J

2003-11-30

The goal of this study is to address directly the predictive value of birth inputs and outputs, particularly birth weight, for measures of early childhood development in a simultaneous equations modelling framework. Strikingly, birth outputs have virtually no structural/causal effects on early childhood developmental outcomes, and only maternal smoking and drinking during pregnancy have some effects on child height. Not surprisingly, family child-rearing environment has sizeable negative and positive effects on a behavioural problems index and a mathematics/reading test score, respectively, and a mildly surprising negative effect on child height. Despite little evidence of a structural/causal effect of birth weight on early childhood developmental outcomes, our results demonstrate that birth weight nonetheless has strong predictive effects on early childhood outcomes. Furthermore, these effects are largely invariant to whether family child-rearing environment is taken into account. Family child-rearing environment has both structural and predictive effects on early childhood outcomes, but they are largely orthogonal and in addition to the effects of birth weight. Copyright 2003 John Wiley & Sons, Ltd.

A 32-bit NMOS microprocessor with a large register file

NASA Astrophysics Data System (ADS)

Sherburne, R. W., Jr.; Katevenis, M. G. H.; Patterson, D. A.; Sequin, C. H.

1984-10-01

Two scaled versions of a 32-bit NMOS reduced instruction set computer CPU, called RISC II, have been implemented on two different processing lines using the simple Mead and Conway layout rules with lambda values of 2 and 1.5 microns (corresponding to drawn gate lengths of 4 and 3 microns), respectively. The design utilizes a small set of simple instructions in conjunction with a large register file in order to provide high performance. This approach has resulted in two surprisingly powerful single-chip processors.

Interplay between type IV pili activity and exopolysaccharides secretion controls motility patterns in single cells of Myxococcus xanthus

PubMed Central

Hu, Wei; Gibiansky, Maxsim L.; Wang, Jing; Wang, Chuandong; Lux, Renate; Li, Yuezhong; Wong, Gerard C. L.; Shi, Wenyuan

2016-01-01

Myxococcus xanthus performs coordinated social motility of cell groups through the extension and retraction of type IV pili (TFP) on solid surfaces, which requires both TFP and exopolysaccharides (EPS). By submerging cells in a liquid medium containing 1% methylcellulose, M. xanthus TFP-driven motility was induced in isolated cells and independently of EPS. We measured and analyzed the movements of cells using community tracking algorithms, which combine single-cell resolution with statistics from large sample populations. Cells without significant multi-cellular social interactions have surprisingly complex behaviors: EPS− cells exhibited a pronounced increase in the tendency to stand vertically and moved with qualitatively different characteristics than other cells. A decrease in the EPS secretion of cells correlates with a higher instantaneous velocity, but with lower directional persistence in trajectories. Moreover, EPS− cells do not adhere to the surface as strongly as wild-type and EPS overproducing cells, and display a greater tendency to have large deviations between the direction of movement and the cell axis, with cell velocity showing only minimal dependence on the direction of movement. The emerging picture is that EPS does not simply provide rheological resistance to a single mechanism but rather that the availability of EPS impacts motility pattern. PMID:26821939

IER 203 CED-2 Report: LLNL Final Design for BERP Ball With a Composite Reflector of Thin Polyethylene Backed by Nickel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Percher, C. M.; Heinrichs, D. P.; Kim, S. K.

2016-07-18

This report documents the results of final design (CED-2) for IER 203, BERP Ball Composite Reflection, and focuses on critical configurations with a 4.5 kg α-phase plutonium sphere reflected by a combination of thin high-density polyethylene (HDPE) backed by a thick nickel reflector. The Lawrence Livermore National Laboratory’s (LLNL’s) Nuclear Criticality Safety Division, in support of fissile material operations, calculated surprisingly reactive configurations when a fissile core was surrounded by a thin, moderating reflector backed by a thick metal reflector. These composite reflector configurations were much more reactive than either of the single reflector materials separately. The calculated findings havemore » resulted in a stricter-than-anticipated criticality control set, impacting programmatic work. IER 203 was requested in response to these seemingly anomalous calculations to see if the composite reflection effect could be shown experimentally. This report focuses on the Beryllium Reflected Plutonium (BERP) ball as a fissile material core reflected by polyethylene and nickel. A total of four critical configurations were designed as part of CED-2. Fabrication costs are estimated to be $98,500, largely due to the cost of the large nickel reflectors. The IER 203 experiments could reasonably be expected to begin in early FY2017.« less

Estimating the Economic Payoff to Virtual University Education: A Case Study of the Open University of Catalonia

ERIC Educational Resources Information Center

Castaño-Muñoz, Jonatan; Carnoy, Martin; Duart, Josep M.

2016-01-01

There is surprisingly little analysis of the employment and earnings impact on students of taking and completing Internet-based programs and of how it compares with earnings outcomes for graduates of face-to-face universities. This paper analyzes a follow-up survey of students who began attending the virtual Internet-based Open University of…

Circles of Influence: Rational Decision-Making, Strategic Positioning, and the Formation of Charter School Clusters in New Jersey

ERIC Educational Resources Information Center

d'Entremont, Chad

2012-01-01

A major focus of charter school research has been the potential impact of increased school choice on student sorting by race/ethnicity and socio-economic status. Researchers have argued that charter schools may increase segregation by allowing families to separate into more homogeneous school communities. Yet surprisingly, little attention has…

Top 10 astronomy stories of 2005

NASA Astrophysics Data System (ADS)

Reddy, Francis

2006-01-01

Spacecraft explored two planets and touched a comet, while astronomers puzzled over an errant asteroid, larger galaxies, and a titanic explosion in space. (10) Blast from beyond; (9) Exoplanet surprises; (8) An asteroid among us; (7) Return to space; (6) A year at Saturn ... (5) ... and two at Mars; (4) Deep impact; (3) Bigger, better galaxies; (2) The tenth planet; (1) Huygens lands on Titan.

College Students' Attitude toward the Medium of Instruction: Arabic versus English Dilemma

ERIC Educational Resources Information Center

Ellili-Cherif, Maha; Alkhateeb, Haitham

2015-01-01

In 2012, the Supreme Education Council of the State of Qatar decreed a change from English to Arabic as a medium of instruction in four of the colleges of Qatar University. This surprise move created much controversy, especially among the students, the first stakeholders to be affected by this decision, related to the impact this change would have…

101 Damnations: The Persistence of Criticism and the Absence of Evidence about Teacher Education in Australia

ERIC Educational Resources Information Center

Louden, William

2008-01-01

There have been 101 government inquiries of one sort or another into Australian teacher education since 1979. Most have presumed or documented concerns about the performance of teacher education. There has, however, been surprisingly little impact from the reports of these many inquiries. They have not--so far--increased the relatively low level…

The ambiguity of simplicity in quantum and classical simulation

NASA Astrophysics Data System (ADS)

Aghamohammadi, Cina; Mahoney, John R.; Crutchfield, James P.

2017-04-01

A system's perceived simplicity depends on whether it is represented classically or quantally. This is not so surprising, as classical and quantum physics are descriptive frameworks built on different assumptions that capture, emphasize, and express different properties and mechanisms. What is surprising is that, as we demonstrate, simplicity is ambiguous: the relative simplicity between two systems can change sign when moving between classical and quantum descriptions. Here, we associate simplicity with small model-memory. We see that the notions of absolute physical simplicity at best form a partial, not a total, order. This suggests that appeals to principles of physical simplicity, via Ockham's Razor or to the ;elegance; of competing theories, may be fundamentally subjective. Recent rapid progress in quantum computation and quantum simulation suggest that the ambiguity of simplicity will strongly impact statistical inference and, in particular, model selection.

Impact of dynamic rate coding aspects of mobile phone networks on forensic voice comparison.

PubMed

Alzqhoul, Esam A S; Nair, Balamurali B T; Guillemin, Bernard J

2015-09-01

Previous studies have shown that landline and mobile phone networks are different in their ways of handling the speech signal, and therefore in their impact on it. But the same is also true of the different networks within the mobile phone arena. There are two major mobile phone technologies currently in use today, namely the global system for mobile communications (GSM) and code division multiple access (CDMA) and these are fundamentally different in their design. For example, the quality of the coded speech in the GSM network is a function of channel quality, whereas in the CDMA network it is determined by channel capacity (i.e., the number of users sharing a cell site). This paper examines the impact on the speech signal of a key feature of these networks, namely dynamic rate coding, and its subsequent impact on the task of likelihood-ratio-based forensic voice comparison (FVC). Surprisingly, both FVC accuracy and precision are found to be better for both GSM- and CDMA-coded speech than for uncoded. Intuitively one expects FVC accuracy to increase with increasing coded speech quality. This trend is shown to occur for the CDMA network, but, surprisingly, not for the GSM network. Further, in respect to comparisons between these two networks, FVC accuracy for CDMA-coded speech is shown to be slightly better than for GSM-coded speech, particularly when the coded-speech quality is high, but in terms of FVC precision the two networks are shown to be very similar. Copyright © 2015 The Chartered Society of Forensic Sciences. Published by Elsevier Ireland Ltd. All rights reserved.

Discovery, Controls, and Hazards of Widespread Deep-Seated Gravitational Slope Deformation in the Etsumi Mountains, Central Japan

NASA Astrophysics Data System (ADS)

Kaneda, Heitaro; Kono, Taiyo

2017-12-01

Deep-seated gravitational slope deformation (DSGSD) is a largely unnoticed but important long-term mass wasting process that may result in catastrophic failure of mountain slopes. Manifested by small topographic irregularities such as ridge-parallel scarps and linear depressions, it has been predominantly reported in alpine landscapes above timber lines. On the basis of area-wide high-resolution topographic data acquired by light detection and ranging (lidar) surveys, we here show that 96% of existing gravitational scarps have been hidden under forest canopies in the Etsumi Mountains, central Japan. The scarps are surprisingly widespread over the mountains with a mean line density of as large as 0.87 km/km2. Our analyses of the scarp distribution suggest that uphill-facing scarps are primary geomorphic signals of DSGSD with a destabilized rock mass larger than 105 m2, whereas downhill-facing scarps principally occur in response to more localized slope deformation. In terms of controls, topography is by far the most influential factor in triggering and promoting DSGSD. Despite the M 7.5 earthquake in 1891, impact of large local earthquakes proves to be not very strong. Comparison with preexisting landslide maps further suggests that DSGSD and large-scale landslides are not different slope processes but represent different stages of the same process. Our results highlight limitations of aerial-photograph interpretation in forest-covered mountains and the need for lidar-assisted mapping for deeper understanding of this long-term process and interactions between surface and tectonic processes.

Emergence of two lamellas during impact of compound droplets

NASA Astrophysics Data System (ADS)

Liu, Dongdong; Tran, Tuan

2018-05-01

A compound droplet consisting of water and silicone oil either spreads or splashes upon impacting a solid surface. We show that the transition from spreading to splashing of this type of compound droplet can be changed by varying the volumetric oil ratio in the droplets. In the spreading regime, we observe a surprising emergence of two lamellas spreading one after the other: the first spreading lamella consists of only oil and the trailing one water. We show that the two lamellas eventually meet, significantly affecting the spreading dynamics. Finally, we quantify the maximum spreading radius and show that it is a function of both the impact velocity and the volumetric oil ratio.

Revisiting the immune microenvironment of diffuse large B-cell lymphoma using a tissue microarray and immunohistochemistry: robust semi-automated analysis reveals CD3 and FoxP3 as potential predictors of response to R-CHOP

PubMed Central

Coutinho, Rita; Clear, Andrew J.; Mazzola, Emanuele; Owen, Andrew; Greaves, Paul; Wilson, Andrew; Matthews, Janet; Lee, Abigail; Alvarez, Rute; da Silva, Maria Gomes; Cabeçadas, José; Neuberg, Donna; Calaminici, Maria; Gribben, John G.

2015-01-01

Gene expression studies have identified the microenvironment as a prognostic player in diffuse large B-cell lymphoma. However, there is a lack of simple immune biomarkers that can be applied in the clinical setting and could be helpful in stratifying patients. Immunohistochemistry has been used for this purpose but the results are inconsistent. We decided to reinvestigate the immune microenvironment and its impact using immunohistochemistry, with two systems of image analysis, in a large set of patients with diffuse large B-cell lymphoma. Diagnostic tissue from 309 patients was arrayed onto tissue microarrays. Results from 161 chemoimmunotherapy-treated patients were used for outcome prediction. Positive cells, percentage stained area and numbers of pixels/area were quantified and results were compared with the purpose of inferring consistency between the two semi-automated systems. Measurement cutpoints were assessed using a recursive partitioning algorithm classifying results according to survival. Kaplan-Meier estimators and Fisher exact tests were evaluated to check for significant differences between measurement classes, and for dependence between pairs of measurements, respectively. Results were validated by multivariate analysis incorporating the International Prognostic Index. The concordance between the two systems of image analysis was surprisingly high, supporting their applicability for immunohistochemistry studies. Patients with a high density of CD3 and FoxP3 by both methods had a better outcome. Automated analysis should be the preferred method for immunohistochemistry studies. Following the use of two methods of semi-automated analysis we suggest that CD3 and FoxP3 play a role in predicting response to chemoimmunotherapy in diffuse large B-cell lymphoma. PMID:25425693

Revisiting the immune microenvironment of diffuse large B-cell lymphoma using a tissue microarray and immunohistochemistry: robust semi-automated analysis reveals CD3 and FoxP3 as potential predictors of response to R-CHOP.

PubMed

Coutinho, Rita; Clear, Andrew J; Mazzola, Emanuele; Owen, Andrew; Greaves, Paul; Wilson, Andrew; Matthews, Janet; Lee, Abigail; Alvarez, Rute; da Silva, Maria Gomes; Cabeçadas, José; Neuberg, Donna; Calaminici, Maria; Gribben, John G

2015-03-01

Gene expression studies have identified the microenvironment as a prognostic player in diffuse large B-cell lymphoma. However, there is a lack of simple immune biomarkers that can be applied in the clinical setting and could be helpful in stratifying patients. Immunohistochemistry has been used for this purpose but the results are inconsistent. We decided to reinvestigate the immune microenvironment and its impact using immunohistochemistry, with two systems of image analysis, in a large set of patients with diffuse large B-cell lymphoma. Diagnostic tissue from 309 patients was arrayed onto tissue microarrays. Results from 161 chemoimmunotherapy-treated patients were used for outcome prediction. Positive cells, percentage stained area and numbers of pixels/area were quantified and results were compared with the purpose of inferring consistency between the two semi-automated systems. Measurement cutpoints were assessed using a recursive partitioning algorithm classifying results according to survival. Kaplan-Meier estimators and Fisher exact tests were evaluated to check for significant differences between measurement classes, and for dependence between pairs of measurements, respectively. Results were validated by multivariate analysis incorporating the International Prognostic Index. The concordance between the two systems of image analysis was surprisingly high, supporting their applicability for immunohistochemistry studies. Patients with a high density of CD3 and FoxP3 by both methods had a better outcome. Automated analysis should be the preferred method for immunohistochemistry studies. Following the use of two methods of semi-automated analysis we suggest that CD3 and FoxP3 play a role in predicting response to chemoimmunotherapy in diffuse large B-cell lymphoma. Copyright© Ferrata Storti Foundation.

The New Surprising Behaviour of the Two 'Prototype' Blazars PKS 2155-304 and 3C 279

DOE Office of Scientific and Technical Information (OSTI.GOV)

Costamante, Luigi; /Stanford U., HEPL /KIPAC, Menlo Park; Aharonian, Felix

2011-11-21

Recent VHE observations have unveiled a surprising behaviour in two well-known blazars at opposite sides of the blazar sequence. PKS 2155-304 have shown for the first time in an HBL a large Compton dominance, high {gamma}-ray luminosities and a cubic relation between X-ray and VHE fluxes. 3C 279 is the first FSRQ detected at VHE. The high luminosity required to overcome the significant absorption caused by the BLR emission cannot be easily reconciled with the historical and quasi-simultaneous SED properties. Both cases shed a new light on the structure and ambient fields of blazars. Contrary to previous claims, it ismore » also shown that 3C 279 - as any FSRQ - cannot provide robust constraints on the EBL.« less

The transcriptional landscape of αβ T cell differentiation

PubMed Central

Mingueneau, Michael; Kreslavsky, Taras; Gray, Daniel; Heng, Tracy; Cruse, Richard; Ericson, Jeffrey; Bendall, Sean; Spitzer, Matt; Nolan, Garry; Kobayashi, Koichi; von Boehmer, Harald; Mathis, Diane; Benoist, Christophe

2013-01-01

αβT cell differentiation from thymic precursors is a complex process, explored here with the breadth of ImmGen expression datasets, analyzing how differentiation of thymic precursors gives rise to transcriptomes. After surprisingly gradual changes though early T commitment, transit through the CD4+CD8+ stage involves a shutdown or rare breadth, and correlating tightly with MYC. MHC-driven selection promotes a large-scale transcriptional reactivation. We identify distinct signatures that mark cells destined for positive selection versus apoptotic deletion. Differential expression of surprisingly few genes accompany CD4 or CD8 commitment, a similarity that carries through to peripheral T cells and their activation, revealed by mass cytometry phosphoproteomics. The novel transcripts identified as candidate mediators of key transitions help define the “known unknown” of thymocyte differentiation. PMID:23644507

Surprise Realistic Mock Disasters—The Most Effective Means of Disaster Training

PubMed Central

Campanale, Ralph P.

1964-01-01

Realism introduced in several large scale surprise mock-disaster tests proved to be a real challenge to a disaster-conscious hospital staff that had previously undergone fairly extensive disaster training and testing, utilizing conventional methods. Serious weaknesses, flaws, omissions and deficiencies in disaster capability were dramatically and conclusively revealed by use of what appeared to be a “live” disaster setting with smoke, fire, explosions; adverse weather and light conditions; realistically-simulated “casualites” especially prepared not only to look but to act the part; selected harassment incidents from well-documented disasters, such as utility failures, automobile accident on the main access route, overload of telephone switchboard, and invasion of hospital and disaster site by distraught relatives and the morbidly curious. Imagesp436-ap436-bp436-c PMID:14232161

Increased survival of honeybees in the laboratory after simultaneous exposure to low doses of pesticides and bacteria.

PubMed

Dickel, Franziska; Münch, Daniel; Amdam, Gro Vang; Mappes, Johanna; Freitak, Dalial

2018-01-01

Recent studies of honeybees and bumblebees have examined combinatory effects of different stressors, as insect pollinators are naturally exposed to multiple stressors. At the same time the potential influences of simultaneously occurring agricultural agents on insect pollinator health remain largely unknown. Due to different farming methods, and the drift of applied agents and manure, pollinators are most probably exposed to insecticides but also bacteria from organic fertilizers at the same time. We orally exposed honeybee workers to sub-lethal doses of the insecticide thiacloprid and two strains of the bacterium Enterococcus faecalis, which can occur in manure from farming animals. Our results show that under laboratory conditions the bees simultaneously exposed to the a bacterium and the pesticide thiacloprid thiacloprid had significant higher survival rates 11 days post exposure than the controls, which surprisingly showed the lowest survival. Bees that were exposed to diet containing thiacloprid showed decreased food intake. General antibacterial activity is increased by the insecticide and the bacteria, resulting in a higher immune response observed in treated individuals compared to control individuals. We thus propose that caloric restriction through behavioural and physiological adaptations may have mediated an improved survival and stress resistance in our tests. However, the decreased food consumption could in long-term also result in possible negative effects at colony level. Our study does not show an additive negative impact of sub-lethal insecticide and bacteria doses, when tested under laboratory conditions. In contrast, we report seemingly beneficial effects of simultaneous exposure of bees to agricultural agents, which might demonstrate a surprising biological capacity for coping with stressors, possibly through hormetic regulation.

TU-C-BRE-05: Clinical Implications of AAA Commissioning Errors and Ability of Common Commissioning ' Credentialing Procedures to Detect Them

DOE Office of Scientific and Technical Information (OSTI.GOV)

McVicker, A; Oldham, M; Yin, F

2014-06-15

Purpose: To test the ability of the TG-119 commissioning process and RPC credentialing to detect errors in the commissioning process for a commercial Treatment Planning System (TPS). Methods: We introduced commissioning errors into the commissioning process for the Anisotropic Analytical Algorithm (AAA) within the Eclipse TPS. We included errors in Dosimetric Leaf Gap (DLG), electron contamination, flattening filter material, and beam profile measurement with an inappropriately large farmer chamber (simulated using sliding window smoothing of profiles). We then evaluated the clinical impact of these errors on clinical intensity modulated radiation therapy (IMRT) plans (head and neck, low and intermediate riskmore » prostate, mesothelioma, and scalp) by looking at PTV D99, and mean and max OAR dose. Finally, for errors with substantial clinical impact we determined sensitivity of the RPC IMRT film analysis at the midpoint between PTV and OAR using a 4mm distance to agreement metric, and of a 7% TLD dose comparison. We also determined sensitivity of the 3 dose planes of the TG-119 C-shape IMRT phantom using gamma criteria of 3% 3mm. Results: The largest clinical impact came from large changes in the DLG with a change of 1mm resulting in up to a 5% change in the primary PTV D99. This resulted in a discrepancy in the RPC TLDs in the PTVs and OARs of 7.1% and 13.6% respectively, which would have resulted in detection. While use of incorrect flattening filter caused only subtle errors (<1%) in clinical plans, the effect was most pronounced for the RPC TLDs in the OARs (>6%). Conclusion: The AAA commissioning process within the Eclipse TPS is surprisingly robust to user error. When errors do occur, the RPC and TG-119 commissioning credentialing criteria are effective at detecting them; however OAR TLDs are the most sensitive despite the RPC currently excluding them from analysis.« less

Ships Passing in the Night?

ERIC Educational Resources Information Center

Mathews, David

2014-01-01

Marguerite Shaffer, director of American Studies at Miami University, is one of a surprisingly large number of faculty members who are at odds with an academic culture that isn't hospitable to their efforts to combine a public life with a scholarly career. She is concerned about what is happening in her field and about the world her two children…

The Development of Change Blindness: Children's Attentional Priorities whilst Viewing Naturalistic Scenes

ERIC Educational Resources Information Center

Fletcher-Watson, S.; Collis, J. M.; Findlay, J. M.; Leekam, S. R.

2009-01-01

Change blindness describes the surprising difficulty of detecting large changes in visual scenes when changes occur during a visual disruption. In order to study the developmental course of this phenomenon, a modified version of the flicker paradigm, based on Rensink, O'Regan & Clark (1997), was given to three groups of children aged 6-12 years…

Large-scale diversity patterns in spore communities of Arbuscular mycorrhizal fungi [Chapter 2

Treesearch

Javier Alvarez-Sanchez; Nancy C. Johnson; Anita Antoninka; V. Bala Chaudhary; Matthew K. Lau; Suzanne M. Owen; Patricia Gauadarrama; Silvia Castillo

2010-01-01

Surprising little is known about the factors controlling Arbuscular Mycorrhizal (AM) fungal diversity and distribution patterns. A better understanding of these factors is necessary before mycorrhizas can be effectively managed for their benefits in ecosystem restoration and agriculture. The goal of this chapter is to examine the relationships between AM fungal...

Colleges Leverage Large Endowments to Benefit Some Donors and Employees

ERIC Educational Resources Information Center

Hermes, J. J.

2008-01-01

College endowments have beaten the market so consistently in recent years, it is not surprising that individuals would like to take advantage of that institutional wisdom to invest their own money. Increasingly, many are. A small but growing number of universities are trying to entice donors to invest their trusts alongside college endowments,…

Online Texts and Conventional Texts: Estimating, Comparing, and Reducing the Greenhouse Gas Footprint of Two Tools of the Trade

ERIC Educational Resources Information Center

Gattiker, Thomas F.; Lowe, Scott E.; Terpend, Regis

2012-01-01

Many universities are endeavoring to understand and reduce their greenhouse gas (GHG) emissions--or carbon footprints. Hard-copy textbooks are (perhaps surprisingly) a large component of this footprint. Because they are "virtual," electronic texts (e-texts) are often considered environmentally superior to conventional hard-copy texts.…

Career Funneling: How Elite Students Learn to Define and Desire ''Prestigious'' Jobs

ERIC Educational Resources Information Center

Binder, Amy J.; Davis, Daniel B.; Bloom, Nick

2016-01-01

Elite universities are credited as launch points for the widest variety of meaningful careers. Yet, year after year at the most selective universities, nearly half the graduating seniors head to a surprisingly narrow band of professional options. Over the past few decades, this has largely been into the finance and consulting sectors, but…

Estimating Teacher Turnover Costs: A Case Study

ERIC Educational Resources Information Center

Levy, Abigail Jurist; Joy, Lois; Ellis, Pamela; Jablonski, Erica; Karelitz, Tzur M.

2012-01-01

High teacher turnover in large U.S. cities is a critical issue for schools and districts, and the students they serve; but surprisingly little work has been done to develop methodologies and standards that districts and schools can use to make reliable estimates of turnover costs. Even less is known about how to detect variations in turnover costs…

Questioning in Simulated Accountant-Client Consultations: Exploring Implications for ESP Teaching

ERIC Educational Resources Information Center

Burns, Anne; Moore, Stephen

2008-01-01

The field of accountancy plays a vital role in the financial health of modern-day economies. It also attracts very large numbers of students, many for whom English is not their first language, who train in a variety of undergraduate and postgraduate programs at English-medium universities. Yet, surprisingly, the discourse of accountants has been…

Just What the Doctor Should Have Ordered: A Prescription for Sex-Fair School Health Services.

ERIC Educational Resources Information Center

Dunkle, Margaret C.

Inequitable health care for males and females is surprisingly commonplace. Despite this, health care providers, civil rights groups, educators, and even women's rights advocates have largely overlooked the issue. The 11 chapters of this document provide the first extensive civil rights view of sex discrimination in health services. Using Title IX…

Corporate Characteristics, Political Embeddedness and Environmental Pollution by Large U.S. Corporations

ERIC Educational Resources Information Center

Prechel, Harland; Zheng, Lu

2012-01-01

Organizational and environmental sociology contain surprisingly few studies of the corporation as one of the sources of environmental pollution. To fill this gap, we focus on the parent company as the unit of analysis and elaborate environmental theories that focus on the organizational and political-legal causes of pollution. Using a compiled…

The blind men and the elephant: the impact of context and scale in evaluating conflicts between plant hydraulic safety and efficiency

Treesearch

Frederick C. Meinzer; Katherine A. McCulloh; Barbara Lachenbruch; David R. Woodruff; Daniel M. Johnson

2010-01-01

Given the fundamental importance of xylem safety and efficiency for plant survival and fitness, it is not surprising that these are among the most commonly studied features of hydraulic architecture. However, much remains to be learned about the nature and universality of conflicts between hydraulic safety and efficiency. Although selection for suites of hydraulic...

Identifying Potential Implications of Technologies on Military and Security Options

DTIC Science & Technology

2006-06-01

Technology Readiness Level (TRL) ratings. THE DISCUSSION Technology surprise occurs through the use of rapidly-emerging and disruptive technologies by...NATO RTB Systems Analysis and Studies Panel, Exploratory Team on the Impact of Disruptive Technologies The objectives of this task group (TG...Workshop on Emerging Disruptive Technologies and the Implications for Defence advanced the view that TTCP should examine the potential of emerging

Balancing Work and Academics in College: Why Do Students Working 10 to 19 Hours Per Week Excel?

ERIC Educational Resources Information Center

Dundes, Lauren; Marx, Jeff

2007-01-01

Given that 74% of undergraduates work an average of 25.5 hours per week while going to school, we know surprisingly little about how off-campus employment affects undergraduates and to what extent its impact varies by the number of hours worked. Our survey of undergraduates at a small liberal arts college found that the academic performance of…

Inadvertent Weather Modification in Urban Areas: Lessons for Global Climate Change.

NASA Astrophysics Data System (ADS)

Changnon, Stanley A.

1992-05-01

Large metropolitan areas in North America, home to 65% of the nation's population, have created major changes in their climates over the past 150 years. The rate and amount of the urban climate change approximate those being predicted globally using climate models. Knowledge of urban weather and climate modification holds lessons for the global climate change issue. First, adjustments to urban climate changes can provide guidance for adjusting to global change. A second lesson relates to the difficulty but underscores the necessity of providing scientifically credible proof of change within the noise of natural climatic variability. The evolution of understanding about how urban conditions influence weather reveals several unexpected outcomes, particularly relating to precipitation changes. These suggest that similar future surprises can be expected in a changed global climate, a third lesson. In-depth studies of how urban climate changes affected the hydrologic cycle, the regional economy, and human activities were difficult because of data problems, lack of impact methodology, and necessity for multi disciplinary investigations. Similar impact studies for global climate change will require diverse scientific talents and funding commitments adequate to measure the complexity of impacts and human adjustments. Understanding the processes whereby urban areas and other human activities have altered the atmosphere and changed clouds and precipitation regionally appears highly relevant to the global climate-change issue. Scientific and governmental policy development needs to recognize an old axiom that became evident in the studies of inadvertent urban and regional climate change and their behavioral implications: Think globally but act locally. Global climate change is an international issue, and the atmosphere must be treated globally. But the impacts and the will to act and adjust will occur regionally.

Sequential population study of the impact of earthquakes on the emotional and behavioural well-being of 4-year-olds in Canterbury, New Zealand.

PubMed

Thomson, Janine; Seers, Kara; Frampton, Chris; Hider, Phil; Moor, Stephanie

2016-01-01

Exposure to a large natural disaster can lead to behavioural disturbances, developmental delay and anxiety among young children. Although most children are resilient, some will develop mental health problems. Major earthquakes occurred in Canterbury, New Zealand, in September 2010 and February 2011. A community screening tool assessing behavioural and emotional problems in children, the Strengths and Difficulties Questionnaire, has been reported by parents (SDQ-P) and teachers (SDQ-T) of all 4-year-olds in the region since 2008. Mean total and subtest scores for the SDQ-P and SDQ-T were compared across periods before, during and after the earthquakes in sequential population cohorts of children. Comparisons across the periods were made in relation to the proportions of children defined by New Zealand norms as 'abnormal'. Results were also compared between zones considered to have been exposed to higher or lower impact from the earthquakes. Parent mean total SDQ scores did not change between periods before, during and after the earthquakes. Teacher mean SDQ total scores significantly reduced (improved) when compared between baseline and post-earthquake periods. Mean SDQ pro-social scores from both teachers and parents increased (strengthened) when compared between baseline and post-earthquake periods. Results did not significantly vary according to a measure of impact from the earthquakes. The main finding that a population-based measure of behavioural and emotional problems among children was not deleteriously impacted by the earthquakes is surprising and is not consistent with other research findings. Further work is needed to explore the health needs of children in Canterbury based on methodological improvements. © 2015 The Authors. Journal of Paediatrics and Child Health © 2015 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

Optimal faces for gender and expression: a new technique for measuring dynamic templates used in face perception.

PubMed

Poirier, Frédéric J A M; Faubert, Jocelyn

2012-06-22

Facial expressions are important for human communications. Face perception studies often measure the impact of major degradation (e.g., noise, inversion, short presentations, masking, alterations) on natural expression recognition performance. Here, we introduce a novel face perception technique using rich and undegraded stimuli. Participants modified faces to create optimal representations of given expressions. Using sliders, participants adjusted 53 face components (including 37 dynamic) including head, eye, eyebrows, mouth, and nose shape and position. Data was collected from six participants and 10 conditions (six emotions + pain + gender + neutral). Some expressions had unique features (e.g., frown for anger, upward-curved mouth for happiness), whereas others had shared features (e.g., open eyes and mouth for surprise and fear). Happiness was different from other emotions. Surprise was different from other emotions except fear. Weighted sum morphing provides acceptable stimuli for gender-neutral and dynamic stimuli. Many features were correlated, including (1) head size with internal feature sizes as related to gender, (2) internal feature scaling, and (3) eyebrow height and eye openness as related to surprise and fear. These findings demonstrate the method's validity for measuring the optimal facial expressions, which we argue is a more direct measure of their internal representations.

Undervaluing Gratitude: Expressers Misunderstand the Consequences of Showing Appreciation.

PubMed

Kumar, Amit; Epley, Nicholas

2018-06-01

Expressing gratitude improves well-being for both expressers and recipients, but we suggest that an egocentric bias may lead expressers to systematically undervalue its positive impact on recipients in a way that could keep people from expressing gratitude more often in everyday life. Participants in three experiments wrote gratitude letters and then predicted how surprised, happy, and awkward recipients would feel. Recipients then reported how receiving an expression of gratitude actually made them feel. Expressers significantly underestimated how surprised recipients would be about why expressers were grateful, overestimated how awkward recipients would feel, and underestimated how positive recipients would feel. Expected awkwardness and mood were both correlated with participants' willingness to express gratitude. Wise decisions are guided by an accurate assessment of the expected value of action. Underestimating the value of prosocial actions, such as expressing gratitude, may keep people from engaging in behavior that would maximize their own-and others'-well-being.

The impact of various browse feeds with different tannin content on the fecal shedding of Clostridium perfringens in West African dwarf sheep.

PubMed

Aschfalk, A; Müller, W; Drochner, W

2000-01-01

In 1994 and 1995 leaves from eight browse feeds, containing tannins in different amounts (BF), were fed to West African Dwarf Sheep in Benin to evaluate their impact on Clostridium perfringens in the intestinal tract. An inhibitory impact of various BF on the growth of C. perfringens was assessed in in-vitro assays before, and thus a potential use of these leaves as a preventive diet against C. perfringens enterotoxemia in small ruminants was assumed. Surprisingly, an inhibitory impact of the BF on the shedding of C. perfringens in the feces of West African Dwarf Sheep could not be shown in seven of the eight BF examined. However, the pattern of inhibition of unlike C. perfringens toxovars may differ and a selective inhibitory impact of the BF Dialium guineense on C. perfringens toxovar D may be assumed.

Eyeballing the universe

NASA Astrophysics Data System (ADS)

Lintott, Chris; Land, Kate

2008-09-01

Modern astrophysics is a world dominated by large observatories, whether it is the Very Large Telescope in the Atacama desert in Chile or the Hubble Space Telescope orbiting high above the Earth. Access to these facilities is granted only as a result of fierce competition between astronomers, each of whom will have spent years gaining a first degree and a PhD just to be in the game. In the rarefied world of modern research, it may come as a surprise that our project, Galaxy Zoo, is producing science from the work of hundreds of thousands of Web users.

Does technology acceleration equate to mask cost acceleration?

NASA Astrophysics Data System (ADS)

Trybula, Walter J.; Grenon, Brian J.

2003-06-01

The technology acceleration of the ITRS Roadmap has many implications on both the semiconductor sup-plier community and the manufacturers. INTERNATIONAL SEMATECH has revaluated the projected cost of advanced technology masks. Building on the methodology developed in 1996 for mask costs, this work provided a critical review of mask yields and factors relating to the manufacture of photolithography masks. The impact of the yields provided insight into the learning curve for leading edge mask manufac-turing. The projected mask set cost was surprising, and the ability to provide first and second year cost estimates provided additional information on technology introduction. From this information, the impact of technology acceleration can be added to the projected yields to evaluate the impact on mask costs.

Impact-induced acceleration by obstacles

NASA Astrophysics Data System (ADS)

Corbin, N. A.; Hanna, J. A.; Royston, W. R.; Singh, H.; Warner, R. B.

2018-05-01

We explore a surprising phenomenon in which an obstruction accelerates, rather than decelerates, a moving flexible object. It has been claimed that the right kind of discrete chain falling onto a table falls faster than a free-falling body. We confirm and quantify this effect, reveal its complicated dependence on angle of incidence, and identify multiple operative mechanisms. Prior theories for direct impact onto flat surfaces, which involve a single constitutive parameter, match our data well if we account for a characteristic delay length that must impinge before the onset of excess acceleration. Our measurements provide a robust determination of this parameter. This supports the possibility of modeling such discrete structures as continuous bodies with a complicated constitutive law of impact that includes angle of incidence as an input.

The Value of Change: Surprises and Insights in Stellar Evolution

NASA Astrophysics Data System (ADS)

Bildsten, Lars

2018-01-01

Astronomers with large-format cameras regularly scan the sky many times per night to detect what's changing, and telescopes in space such as Kepler and, soon, TESS obtain very accurate brightness measurements of nearly a million stars over time periods of years. These capabilities, in conjunction with theoretical and computational efforts, have yielded surprises and remarkable new insights into the internal properties of stars and how they end their lives. I will show how asteroseismology reveals the properties of the deep interiors of red giants, and highlight how astrophysical transients may be revealing unusual thermonuclear outcomes from exploding white dwarfs and the births of highly magnetic neutron stars. All the while, stellar science has been accelerated by the availability of open source tools, such as Modules for Experiments in Stellar Astrophysics (MESA), and the nearly immediate availability of observational results.

Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight.

PubMed

Anderberg, Rozita H; Richard, Jennifer E; Eerola, Kim; López-Ferreras, Lorena; Banke, Elin; Hansson, Caroline; Nissbrandt, Hans; Berqquist, Filip; Gribble, Fiona M; Reimann, Frank; Wernstedt Asterholm, Ingrid; Lamy, Christophe M; Skibicka, Karolina P

2017-04-01

Glucagon-like peptide 1 (GLP-1) and serotonin play critical roles in energy balance regulation. Both systems are exploited clinically as antiobesity strategies. Surprisingly, whether they interact in order to regulate energy balance is poorly understood. Here we investigated mechanisms by which GLP-1 and serotonin interact at the level of the central nervous system. Serotonin depletion impaired the ability of exendin-4, a clinically used GLP-1 analog, to reduce body weight in rats, suggesting that serotonin is a critical mediator of the energy balance impact of GLP-1 receptor (GLP-1R) activation. Serotonin turnover and expression of 5-hydroxytryptamine (5-HT) 2A (5-HT 2A ) and 5-HT 2C serotonin receptors in the hypothalamus were altered by GLP-1R activation. We demonstrate that the 5-HT 2A , but surprisingly not the 5-HT 2C , receptor is critical for weight loss, anorexia, and fat mass reduction induced by central GLP-1R activation. Importantly, central 5-HT 2A receptors are also required for peripherally injected liraglutide to reduce feeding and weight. Dorsal raphe (DR) harbors cell bodies of serotonin-producing neurons that supply serotonin to the hypothalamic nuclei. We show that GLP-1R stimulation in DR is sufficient to induce hypophagia and increase the electrical activity of the DR serotonin neurons. Finally, our results disassociate brain metabolic and emotionality pathways impacted by GLP-1R activation. This study identifies serotonin as a new critical neural substrate for GLP-1 impact on energy homeostasis and expands the current map of brain areas impacted by GLP-1R activation. © 2017 by the American Diabetes Association.

Surprise beyond prediction error

PubMed Central

Chumbley, Justin R; Burke, Christopher J; Stephan, Klaas E; Friston, Karl J; Tobler, Philippe N; Fehr, Ernst

2014-01-01

Surprise drives learning. Various neural “prediction error” signals are believed to underpin surprise-based reinforcement learning. Here, we report a surprise signal that reflects reinforcement learning but is neither un/signed reward prediction error (RPE) nor un/signed state prediction error (SPE). To exclude these alternatives, we measured surprise responses in the absence of RPE and accounted for a host of potential SPE confounds. This new surprise signal was evident in ventral striatum, primary sensory cortex, frontal poles, and amygdala. We interpret these findings via a normative model of surprise. PMID:24700400

Impact of extracellularity on the evolutionary rate of mammalian proteins.

PubMed

Liao, Ben-Yang; Weng, Meng-Pin; Zhang, Jianzhi

2010-01-06

It is of fundamental importance to understand the determinants of the rate of protein evolution. Eukaryotic extracellular proteins are known to evolve faster than intracellular proteins. Although this rate difference appears to be due to the lower essentiality of extracellular proteins than intracellular proteins in yeast, we here show that, in mammals, the impact of extracellularity is independent from the impact of gene essentiality. Our partial correlation analysis indicated that the impact of extracellularity on mammalian protein evolutionary rate is also independent from those of tissue-specificity, expression level, gene compactness, and the number of protein-protein interactions and, surprisingly, is the strongest among all the factors we examined. Similar results were also found from principal component regression analysis. Our findings suggest that different rules govern the pace of protein sequence evolution in mammals and yeasts.

Impact of Network Activity Levels on the Performance of Passive Network Service Dependency Discovery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carroll, Thomas E.; Chikkagoudar, Satish; Arthur-Durett, Kristine M.

Network services often do not operate alone, but instead, depend on other services distributed throughout a network to correctly function. If a service fails, is disrupted, or degraded, it is likely to impair other services. The web of dependencies can be surprisingly complex---especially within a large enterprise network---and evolve with time. Acquiring, maintaining, and understanding dependency knowledge is critical for many network management and cyber defense activities. While automation can improve situation awareness for network operators and cyber practitioners, poor detection accuracy reduces their confidence and can complicate their roles. In this paper we rigorously study the effects of networkmore » activity levels on the detection accuracy of passive network-based service dependency discovery methods. The accuracy of all except for one method was inversely proportional to network activity levels. Our proposed cross correlation method was particularly robust to the influence of network activity. The proposed experimental treatment will further advance a more scientific evaluation of methods and provide the ability to determine their operational boundaries.« less

Wild Chimpanzees on the Edge: Nocturnal Activities in Croplands

PubMed Central

Krief, Sabrina; Cibot, Marie; Bortolamiol, Sarah; Seguya, Andrew; Krief, Jean-Michel; Masi, Shelly

2014-01-01

In a rapidly changing landscape highly impacted by anthropogenic activities, the great apes are facing new challenges to coexist with humans. For chimpanzee communities inhabiting encroached territories, not bordered by rival conspecifics but by human agricultural fields, such boundaries are risky areas. To investigate the hypothesis that they use specific strategies for incursions out of the forest into maize fields to prevent the risk of detection by humans guarding their field, we carried out video recordings of chimpanzees at the edge of the forest bordered by a maize plantation in Kibale National Park, Uganda. Contrary to our expectations, large parties are engaged in crop-raids, including vulnerable individuals such as females with clinging infants. More surprisingly chimpanzees were crop-raiding during the night. They also stayed longer in the maize field and presented few signs of vigilance and anxiety during these nocturnal crop-raids. While nocturnal activities of chimpanzees have been reported during full moon periods, this is the first record of frequent and repeated nocturnal activities after twilight, in darkness. Habitat destruction may have promoted behavioural adjustments such as nocturnal exploitation of open croplands. PMID:25338066

Evaluation of margins in head and neck squamous cell carcinoma from the surgeon's perspective.

PubMed

Baumeister, Philipp; Baumüller, Konstantin; Harréus, Ulrich; Reiter, Maximilian; Welz, Christian

2018-05-01

The surgeon's evaluation of resection status based on frozen section analysis during operation and pathological examination of resected specimens often differ. For this study, we recapitulated the surgeon's perspective during an operation, accordingly classified the evaluation of margins by the surgeon, and analyzed its impact on the outcome compared with the pathological results. This was a retrospective analysis. As data sources, paper-based and digital patient files, as well as the Munich Cancer Registry database were used. Three hundred ninety-six cases were included in this analysis. Only the evaluation of margins by the surgeon influenced local control, and the pathological results influenced disease-free survival (DFS). Surprisingly, margins of >5 mm of normal tissue to cancer growth led to local control and overall survival (OS) significantly worse than 1 to 5-mm resections. The evaluation of margins by the surgeon is of significant importance for local control and OS. It is largely based on frozen section analysis, which, therefore, should be used whenever possible. © 2018 Wiley Periodicals, Inc.

A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs

PubMed Central

Fulga, Tudor A.; McNeill, Elizabeth M.; Binari, Richard; Yelick, Julia; Blanche, Alexandra; Booker, Matthew; Steinkraus, Bruno R.; Schnall-Levin, Michael; Zhao, Yong; DeLuca, Todd; Bejarano, Fernando; Han, Zhe; Lai, Eric C.; Wall, Dennis P.; Perrimon, Norbert; Van Vactor, David

2015-01-01

Although the impact of microRNAs (miRNAs) in development and disease is well established, understanding the function of individual miRNAs remains challenging. Development of competitive inhibitor molecules such as miRNA sponges has allowed the community to address individual miRNA function in vivo. However, the application of these loss-of-function strategies has been limited. Here we offer a comprehensive library of 141 conditional miRNA sponges targeting well-conserved miRNAs in Drosophila. Ubiquitous miRNA sponge delivery and consequent systemic miRNA inhibition uncovers a relatively small number of miRNA families underlying viability and gross morphogenesis, with false discovery rates in the 4–8% range. In contrast, tissue-specific silencing of muscle-enriched miRNAs reveals a surprisingly large number of novel miRNA contributions to the maintenance of adult indirect flight muscle structure and function. A strong correlation between miRNA abundance and physiological relevance is not observed, underscoring the importance of unbiased screens when assessing the contributions of miRNAs to complex biological processes. PMID:26081261

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stark, Christopher C.; Roberge, Aki; Mandell, Avi

ExoEarth yield is a critical science metric for future exoplanet imaging missions. Here we estimate exoEarth candidate yield using single visit completeness for a variety of mission design and astrophysical parameters. We review the methods used in previous yield calculations and show that the method choice can significantly impact yield estimates as well as how the yield responds to mission parameters. We introduce a method, called Altruistic Yield Optimization, that optimizes the target list and exposure times to maximize mission yield, adapts maximally to changes in mission parameters, and increases exoEarth candidate yield by up to 100% compared to previousmore » methods. We use Altruistic Yield Optimization to estimate exoEarth candidate yield for a large suite of mission and astrophysical parameters using single visit completeness. We find that exoEarth candidate yield is most sensitive to telescope diameter, followed by coronagraph inner working angle, followed by coronagraph contrast, and finally coronagraph contrast noise floor. We find a surprisingly weak dependence of exoEarth candidate yield on exozodi level. Additionally, we provide a quantitative approach to defining a yield goal for future exoEarth-imaging missions.« less

Impact of explosive volcanic eruptions around Vesuvius: a story of resilience in Roman time

NASA Astrophysics Data System (ADS)

Scarpati, Claudio; Perrotta, Annamaria; De Simone, Girolamo Ferdinando

2016-03-01

Large explosive eruptions have reshaped the landscape around Vesuvius many times in prehistoric and historical times. Previous stratigraphic surveys suggested that people living in this area have probably abandoned their settlements (in the Bronze Age) or towns and villas (in the Roman period) for centuries after each major plinian eruption. New archaeological excavations on the northern slope of Vesuvius suggest a much more intriguing scenario. At Pollena Trocchia, an ongoing excavation has shown the superimposition of three different Roman structures, sandwiched between the deposits of the AD 79, AD 472, and AD 512 Vesuvius eruptions. Each of these eruptions more or less completely destroyed and buried the buildings under meters of volcanic products. Surprisingly, after a few years or decades, a new settlement was established exactly on the top of the buried one, indicating the immediate recovery of part of the devastated area. Our research documents the destruction of Roman buildings by volcanic eruptions over a period of five centuries (first to sixth century AD) and provides new insight into human behavior after major explosive eruptions.

Introduction. Computational aerodynamics.

PubMed

Tucker, Paul G

2007-10-15

The wide range of uses of computational fluid dynamics (CFD) for aircraft design is discussed along with its role in dealing with the environmental impact of flight. Enabling technologies, such as grid generation and turbulence models, are also considered along with flow/turbulence control. The large eddy simulation, Reynolds-averaged Navier-Stokes and hybrid turbulence modelling approaches are contrasted. The CFD prediction of numerous jet configurations occurring in aerospace are discussed along with aeroelasticity for aeroengine and external aerodynamics, design optimization, unsteady flow modelling and aeroengine internal and external flows. It is concluded that there is a lack of detailed measurements (for both canonical and complex geometry flows) to provide validation and even, in some cases, basic understanding of flow physics. Not surprisingly, turbulence modelling is still the weak link along with, as ever, a pressing need for improved (in terms of robustness, speed and accuracy) solver technology, grid generation and geometry handling. Hence, CFD, as a truly predictive and creative design tool, seems a long way off. Meanwhile, extreme practitioner expertise is still required and the triad of computation, measurement and analytic solution must be judiciously used.

The Importance of Demonstratively Restoring Order

PubMed Central

Keizer, Kees; Lindenberg, Siegwart; Steg, Linda

2013-01-01

Contrary to what is often assumed, order is not the strongest context for encouraging normative behavior. The strongest context effect on normative behavior comes from cues that clearly convey other people’s respect for norms. Ironically, this show of respect necessitates some contrasting disrespect that is being restored. Using civic virtues (such as helping behavior) as a prototype of normative behavior, the three field experiments described in this paper reveal the impact of normative cues on civic virtues. Results show that the strongest effect on making people follow prosocial norms in public places emanates from seeing order being restored, rather than just order being present. The robust and surprisingly large effects show that observing other people’s respect for one particular norm (as evidenced in their restoring physical order) makes it more likely that the onlooker follows other norms as well. This implies that prosocial behavior has the highest chance of spreading when people observe order being restored. There are clear policy implications: create low cost “normative respect cues” wherever it is desirable to increase conformity to norms. PMID:23755182

Religious ideology, a neglected variable.

PubMed

Unger, Rhoda K

2007-12-01

Comments on an article by J. T. Jost, which presented interesting data relating some personality dimensions to voting patterns in the last three U.S. presidential elections. R. K. Unger is surprised that in his extensive review of the role of ideology, Jost ignored the role of religious ideology in political attitudes and voting behavior. There is ample evidence that level of religious observance (sometimes labeled religiosity, hierarchical religious beliefs, or religious fundamentalism) played a role in 2004 and earlier presidential elections. The relationship between religious ideology and political attitudes is correlational, and one needs to look further for an explanation of their impact. A number of studies indicate relationships between religious fundamentalism and what Jost has termed "system-justifying ideologies." Unger suggests that religiosity has been largely ignored by psychologists interested in social and political behaviors. It is quite possible that religiosity is related to the various personality dimensions discussed by Jost. But we cannot learn more about these potential connections if we continue to ignore the importance of religious ideology as a psychological variable. (Copyright) 2007 APA.

Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae

PubMed Central

Huard, Sylvain; Morettin, Alan; Fullerton, Morgan D.; Côté, Jocelyn

2017-01-01

Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is required for stress granule formation upon glucose deprivation but not heat stress. Further, the Tip60 complex, the human homolog of the NuA4 complex, is required for stress granule formation in cancer cell lines. Surprisingly, the impact of NuA4 on glucose-deprived stress granule formation is partially mediated through regulation of acetyl-CoA levels, which are elevated in NuA4 mutants. While elevated acetyl-CoA levels suppress the formation of glucose-deprived stress granules, decreased acetyl-CoA levels enhance stress granule formation upon glucose deprivation. Further our work suggests that NuA4 regulates acetyl-CoA levels through the Acetyl-CoA carboxylase Acc1. Altogether this work establishes both NuA4 and the metabolite acetyl-CoA as critical signaling pathways regulating the formation of glucose-deprived stress granules. PMID:28231279

Shock wave response of a zirconium-based bulk metallic glass and its composite

NASA Astrophysics Data System (ADS)

Zhuang, Shiming; Lu, Jun; Ravichandran, Guruswami

2002-06-01

A zirconium-based bulk metallic glass, Zr41.2Ti13.8Cu12.5Ni10Be22.5 (Vit 1), and its composite, Zr56.3Ti13.8Cu6.9Ni5.6Nb5.0Be12.5 (beta-Vit), were subjected to planar impact loading. A surprisingly low amplitude elastic precursor and bulk wave, corresponding to the elastic response of the "frozen structure" of the intact metallic glasses, were observed to precede the rate-dependent large deformation shock wave. A concave downward curvature after the initial increase of the Us-Up shock Hugoniots suggests that a phase-change-like transition occurred during shock compression. Further, compression damage occurred due to the shear localization. The spalling in Vit 1 was induced by shear localization, while in beta-Vit, it was due to debonding of the beta-phase boundary from the matrix. The spall strengths at strain rate of 2 x106 s-1 were determined to be 2.35 and 2.11 GPa for Vit 1 and beta-Vit, respectively.

Florida Rising: An Assessment of Public Universities in the Sunshine State

ERIC Educational Resources Information Center

Poliakoff, Michael; Alacbay, Armand

2013-01-01

The State University System of Florida has in recent years faced major budgetary challenges, remarkable for the size of its reductions in state funding, even when compared to the large cuts seen in so many states struck by the recession of 2008. What is more surprising in the world of higher education, however, is the progress that Florida's…

Three-Dimensional Printing of a Scalable Molecular Model and Orbital Kit for Organic Chemistry Teaching and Learning

ERIC Educational Resources Information Center

Penny, Matthew R.; Cao, Zi Jing; Patel, Bhaven; dos Santos, Bruno Sil; Asquith, Christopher R. M.; Szulc, Blanka R.; Rao, Zenobia X.; Muwaffak, Zaid; Malkinson, John P.; Hilton, Stephen T.

2017-01-01

Three-dimensional (3D) chemical models are a well-established learning tool used to enhance the understanding of chemical structures by converting two-dimensional paper or screen outputs into realistic three-dimensional objects. While commercial atom model kits are readily available, there is a surprising lack of large molecular and orbital models…

State U. vs. Target: Who Gets the Better Grade for Employee Treatment?

ERIC Educational Resources Information Center

Boeck, Claire

2014-01-01

The miserable pay of adjuncts and the transformation of colleges and universities into business are no longer foreign concepts in the public realm. What is a surprise, though, is that large companies, such as Target and Starbucks, take better care of their employees than those in higher education. This article focuses on the contrast between the…

Seeing the forest for the trees: hybridity and social-ecological symbols, rituals and resilience in postdisaster contexts

Treesearch

Keith G. Tidball

2014-01-01

The role of community-based natural resources management in the form of "greening" after large scale system shocks and surprises is argued to provide multiple benefits via engagement with living elements of social-ecological systems and subsequent enhanced resilience at multiple scales. The importance of so-called social-ecological symbols, especially the...

Bridging Water Issue Knowledge Gaps between the General Public and Opinion Leaders

ERIC Educational Resources Information Center

Lamm, Kevan W.; Lamm, Alexa J.; Carter, Hannah S.

2015-01-01

Global conflicts have rapidly made water the most contentious issue in the world today. Considering water drives health, industry, recreation, and the agricultural food system it is no surprise that it has become such a hot topic. As a result, the general public has an increased interest in water-focused policy; policy that can have a large impact…

Choosing to Study for a PhD: A Framework for Examining Decisions to Become a Research Student

ERIC Educational Resources Information Center

McCulloch, Alistair; Guerin, Cally; Jayatilaka, Asangi; Calder, Paul; Ranasinghe, Damith

2017-01-01

Given its importance to institutions, policy-makers and intending students, there is a surprising lack of research exploring the reasons students choose to undertake a research degree. What studies there are tend to be largely descriptive and the topic lacks a theoretically-informed framework through which student decisions can be examined and…

Understanding Loan Aversion in Education: Evidence from High School Seniors, Community College Students, and Adults. CEPA Working Paper No. 16-15

ERIC Educational Resources Information Center

Boatman, Angela; Evans, Brent; Soliz, Adela

2016-01-01

Student loans are a crucial aspect of financing a college education for millions of Americans, yet we have surprisingly little empirical evidence concerning individuals' unwillingness to borrow money for educational purposes. This study provides the first large-scale quantitative evidence of levels of loan aversion in the United States. Using…

Effects of Selection and Training on Unit-Level Performance over Time: A Latent Growth Modeling Approach

ERIC Educational Resources Information Center

Van Iddekinge, Chad H.; Ferris, Gerald R.; Perrewe, Pamela L.; Perryman, Alexa A.; Blass, Fred R.; Heetderks, Thomas D.

2009-01-01

Surprisingly few data exist concerning whether and how utilization of job-related selection and training procedures affects different aspects of unit or organizational performance over time. The authors used longitudinal data from a large fast-food organization (N = 861 units) to examine how change in use of selection and training relates to…

Boundaries in Visualizing Mathematical Behaviour

ERIC Educational Resources Information Center

Hare, Andrew Francis

2013-01-01

It is surprising to students to learn that a natural combination of simple functions, the function sin(1/x), exhibits behaviour that is a great challenge to visualize. When x is large the function is relatively easy to draw; as x gets smaller the function begins to behave in an increasingly wild manner. The sin(1/x) function can serve as one of…

Middle-Class Societies Invest More in Public Education: A Stronger Middle Class Is Associated with Higher Levels of Spending on Education

ERIC Educational Resources Information Center

Madland, David; Bunker, Nick

2011-01-01

America's economic future depends in large part on the quality of the nation's public education. Education increases productivity, sparks innovation, and boosts the economic competitiveness. Not surprisingly, the American public thinks that there should be greater investments in education, with polls showing strong and growing support for…

Executive Search Firms' Consideration of Person-Organization Fit in College and University Presidential Searches

ERIC Educational Resources Information Center

Turpin, James Christopher

2013-01-01

Largely what is known about P-O Fit stems from research conducted in business organizations. Surprisingly with such an important position as a college or university president, P-O Fit has not been empirically studied in the presidential selection process, much less from the perspective of the executive search firms that conduct these searches.…

Socio-professional handicap and accidental risk in patients with hypersomnias of central origin.

PubMed

Bayon, Virginie; Léger, Damien; Philip, Pierre

2009-12-01

Narcolepsy and idiopathic hypersomnia profoundly affect quality of life, education and work. Young patients are very handicapped by unexpected sleep episodes during lessons. Professionals frequently complain about sleepiness at work. Motor discomfort (i.e., cataplectic attacks) surprisingly is less handicapping in narcoleptics than sleepiness but only a few studies clearly assess the problem. Quality of life is also largely impaired in its physical and emotional dimensions. Sleepiness is the major factor explaining a decrease of quality of life and unexpectedly cataplectic attacks have little impact on patients. Another potential problem for these patients is the risk of accidents at work or when driving. Narcoleptic and hypersomniac patients have a higher risk of accidents than apneic or insomniac subjects. But, confounding factors such as duration of driving, number of cataplectic attacks or even objective level of alertness are not always entered in the analytic models mainly because of small samples of patients. Unlike in apneic patients, the effect of treatment on accidental risk has not been studied in narcoleptics or in hypersomniacs. Epidemiological data are needed to improve knowledge concerning these areas. Clinical trials assessing the impact of treatment on driving and work are also urgently needed. Finally, medical treatment does not seem to be completely efficient and physicians should pay more attention to the education, work, life and social environment of their patients.

Impact of Genetic Deletion of Platform Apolipoproteins on the Size Distribution of the Murine Lipoproteome

PubMed Central

Gordon, Scott M.; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A.; Shah, Amy S.; Lu, L. Jason; Davidson, W. Sean

2016-01-01

Given their association with cardiovascular disease protection, there has been intense interest in understanding the biology of high density lipoproteins (HDL). HDL is actually a family of diverse particle types, each made up of discrete - but as yet undetermined – combinations of proteins drawn from up to 95 lipophilic plasma proteins. The abundant apolipoproteins (apo) of the A class (apoA-I, apoA-II and apoA-IV) have been proposed to act as organizing platforms for auxiliary proteins, but this concept has not been systematically evaluated. We assessed the impact of genetic knock down of each platform protein on the particle size distribution of auxiliary HDL proteins. Loss of apoA-I or apoA-II massively reduced HDL lipids and changed the plasma size pattern and/or abundance of several plasma proteins. Surprisingly though, many HDL proteins were not affected, suggesting they assemble on lipid particles in the absence of apoA-I or apoA-II. In contrast, apoA-IV ablation had minor effects on plasma lipids and proteins, suggesting that it forms particles that largely exclude other apolipoproteins. Overall, the data indicate that distinct HDL subpopulations exist that do not contain, nor depend on, apoA-I, apoA-II or apoA-IV and these contribute substantially to the proteomic diversity of HDL. PMID:27385375

FDA-approved medications that impair human spermatogenesis.

PubMed

Ding, Jiayi; Shang, Xuejun; Zhang, Zhanhu; Jing, Hua; Shao, Jun; Fei, Qianqian; Rayburn, Elizabeth R; Li, Haibo

2017-02-07

We herein provide an overview of the single-ingredient U.S. Food and Drug Administration (FDA)-approved drugs that affect human spermatogenesis, potentially resulting in a negative impact on male fertility. To provide this information, we performed an in-depth search of DailyMed, the official website for FDA-approved drug labels. Not surprisingly, hormone-based agents were found to be the drugs most likely to affect human spermatogenesis. The next category of drugs most likely to have effects on spermatogenesis was the antineoplastic agents. Interestingly, the DailyMed labels indicated that several anti-inflammatory drugs affect spermatogenesis, which is not supported by the peer-reviewed literature. Overall, there were a total of 65 labels for drugs of various classes that showed that they have the potential to affect human sperm production and maturation. We identified several drugs indicated to be spermatotoxic in the drug labels that were not reported in the peer-reviewed literature. However, the details about the effects of these drugs on human spermatogenesis are largely lacking, the mechanisms are often unknown, and the clinical impact of many of the findings is currently unclear. Therefore, additional work is needed at both the basic research level and during clinical trials and post-marketing surveillance to fill the gaps in the current knowledge. The present findings will be of interest to physicians and pharmacists, researchers, and those involved in drug development and health care policy.

The impact of hydrogenation on the thermal transport of silicene

NASA Astrophysics Data System (ADS)

Liu, Zeyu; Wu, Xufei; Luo, Tengfei

2017-06-01

Silicene, the silicon counterpart of graphene, has been identified as a promising 2D material for electronics applications. The reported very low thermal conductivity of silicene can potentially pose challenges on the thermal management of such nanoelectronics, which can in turn influence the device performance and reliability. Although the thermal conductivity of silicene has been studied, the impact of hydrogenation of silicene, which can happen spontaneously due to the resultant lower energy state, on its thermal transport ability is not clear. In this paper, we use first-principles calculations and iterative solution of phonon Boltzmann transport equation (BTE) to investigate and compare the thermal transport property of silicene and hydrogenated silicene. Surprisingly, we predict that the hydrogenation can lead to a large increase in thermal conductivity (from 22.5 W m-1 K-1 for silicene to 78.0 W m-1 K-1 for hydrogenated silicene at 300 K). We also find that the main contributor for such an improvement is the transverse acoustic phonon modes, and the reasons are the reduced anharmonicity as well as the reduced three-phonon scattering phase space after hydrogenation. This research may help better understand thermal transport in functionalized 2D materials and inspire new strategies to manipulate their thermal properties, which is of critical importance for designing high performance and reliable nanoelectronic devices.

Polarization correlation study of the electron-impact excitation of neon and argon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khakoo, M.A.; McConkey, J.W.

1986-08-11

The recent development of a circular polarization analyzer for the vacuum ultraviolet spectral region has enabled a Stokes parameter analysis to be carried out for the excitation of neon and argon by 80-eV incident electrons. The results show that the transfer of angular momentum to the atom is positive and is in fact surprisingly ''heliumlike.'' Small deviations from total coherence were observed and are discussed.

An oxalyl-CoA dependent pathway of oxalate catabolism plays a role in regulating calcium oxalate crystal accumulation and defending against oxalate-secreting phytopathogens in Medicago truncatula

USDA-ARS?s Scientific Manuscript database

Considering the widespread occurrence of oxalate in nature and its broad impact on a host of organisms, it is surprising that so little is known about the turnover of this important acid. In plants, oxalate oxidase is the most well studied enzyme capable of degrading oxalate, but not all plants pos...

Impact of Institutional Care on Attachment Disorganization and Insecurity of Ukrainian Preschoolers: Protective Effect of the Long Variant of the Serotonin Transporter Gene (5HTT)

ERIC Educational Resources Information Center

Bakermans-Kranenburg, Marian J.; Dobrova-Krol, Natasha; van IJzendoorn, Marinus

2012-01-01

Institutional care has been shown to lead to insecure and disorganized attachments and indiscriminate friendliness. Some children, however, are surprisingly resilient to the adverse environment. Here the protective role of the long variant of the serotonin receptor gene (5HTT) is explored in a small hypothesis-generating study of 37 Ukrainian…

Boosting Postsecondary Education Performance: A Statement by the Policy and Impact Committee of the Committee for Economic Development

ERIC Educational Resources Information Center

Committee for Economic Development, 2012

2012-01-01

It is not troubling, or even surprising, that the United States today faces increasing economic competition from around the world. It is easier for other nations to make up ground on the world's leader by copying more-advanced existing innovations, than it is for the leader to move forward by making new innovations. And as other nations improve…

Air & Space Power Journal. Volume 29, Number 3, May-June 2015

DTIC Science & Technology

2015-06-01

directed-energy beams, radio - frequency strikes, and acoustic weapons, among others.9 One can hardly overstate the impact of cyber, drones, and even newer...showcased the superiority of free societies over their totalitarian counterparts. Not surprisingly, once the Apollo 11 mission fulfilled President...PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11 . SPONSOR/MONITOR’S REPORT

If You Go down to the Woods Today You Are in for a Big Surprise: Seeing the Wood for the Trees in Online Delivery of Career Guidance

ERIC Educational Resources Information Center

Bright, Jim E. H.

2015-01-01

Arguments about online delivery of career development are too frequently couched in polarising terms setting traditional face-to-face guidance practice against online systems. The focus has been on the alleged dehumanising impact of technology and the speed, economy and efficiency of online systems. The possible synergies delivered by the…

Immune Profiling of Pregnant Toxoplasma-Infected US and Colombia Patients Reveals Surprising Impacts of Infection on Peripheral Blood Cytokines

PubMed Central

Pernas, Lena; Ramirez, Raymund; Holmes, Tyson H.; Montoya, José G.; Boothroyd, John C.

2014-01-01

In North America (NA) and Europe, the majority of toxoplasmosis cases are benign and generally asymptomatic, whereas in South America (SA) toxoplasmosis is associated with much more severe symptoms in adults and congenitally infected children. The reasons for these differences remain unknown; currently, there is little information from patients in either region on how the immune system responds to infection with Toxoplasma gondii. Here, we report the relative abundance of 51 serum cytokines from acute and chronic toxoplasmosis cohorts of pregnant women from the United States, where approximately one-half of clinical isolates are Type II, and Colombia, where clinical isolates are generally “atypical” or Type I-like strains. Surprisingly, the results showed notably lower levels of 23 cytokines in acutely infected patients from the United States, relative to uninfected US controls. In acutely infected Colombian patients, however, only 8 cytokine levels differed detectably with 4 being lower and 4 higher relative to uninfected controls. Strikingly, there were also differences in the cytokine profiles of the chronically infected patients relative to uninfected controls in the US cohort. Hence, Toxoplasma appears to specifically impact levels of circulating cytokines, and our results may partly explain region-specific differences in the clinical spectrum of toxoplasmosis. PMID:24664173

The role of cold pools in tropical convective systems

NASA Astrophysics Data System (ADS)

Grant, Leah; Lane, Todd; van den Heever, Susan

2017-04-01

Convective systems in the tropics have received less attention than their midlatitude counterparts, despite their important influences on the global circulation and the state of the tropical atmosphere. It is widely accepted that cold pools play key roles in the intensity, maintenance, and propagation of midlatitude organized convective systems. In the tropics, however, cold pools are weaker because the boundary layer is more humid, and the cold pools may interact with the convective systems differently than in the classic midlatitude system archetype, as suggested by recent studies. The goal of this research is to investigate the physical mechanisms by which cold pools impact tropical convective system intensity and propagation. To address this goal, a simulation of radiative-convective equilibrium (RCE) on a large (3000 km by 200 km) channel domain with an ocean SST of 300 K was conducted at 1 km horizontal resolution, as an idealized representation of the tropical atmosphere. Two different long-lived, organized convective systems - one more intense than the other - were selected from the base RCE simulation and simulated at higher (250 m horizontal) resolution. Next, the cold pools were effectively eliminated by shutting off the sub-cloud evaporation, in order to elucidate their roles in the convective systems' behavior. Surprisingly, the cold pools did not impact the propagation of either convective system. However, they did impact the intensities - cold pools acted to weaken one system but intensify the other system. Through composite analysis and additional simulations including tracers within the cold pools, the physical mechanisms explaining these results have been analyzed and will be presented.

Prevalence and prognosis of stress disorders: a review of the epidemiologic literature

PubMed Central

Gradus, Jaimie L

2017-01-01

Given the ubiquity of traumatic events, it is not surprising that posttraumatic stress disorder (PTSD) – a common diagnosis following one of these experiences – is characterized as conferring a large burden for individuals and society. Although there is recognition of the importance of PTSD diagnoses throughout psychiatry, the literature on other diagnoses one may receive following a stressful or traumatic event is scant. This review summarizes the literature on stress disorders (classified according to the International Classification of Diseases, 10th Edition [ICD-10]), including acute stress reaction, PTSD, adjustment disorder and unspecified stress reactions. This review focuses on the literature related to common psychiatric and somatic consequences of these disorders. The prevalence and incidence of each disorder are described. A review of epidemiologic studies on comorbid mental health conditions, including depression, anxiety and substance abuse, is included, as well as a review of epidemiologic studies on somatic outcomes, including cancer, cardiovascular disease and gastrointestinal disorders. Finally, the current literature on all-cause mortality and suicide following stress disorder diagnoses is reviewed. Stress disorders are a critical public health issue with potentially deleterious outcomes that have a significant impact on those living with these disorders, the health care system and society. It is only through an awareness of the impact of stress disorders that appropriate resources can be allocated to prevention and treatment. Future research should expand the work done to date beyond the examination of PTSD, so that the field may obtain a more complete picture of the impact all stress disorders have on the many people living with these diagnoses. PMID:28496365

Potential Effects of Dams on Migratory Fish in the Mekong River: Lessons from Salmon in the Fraser and Columbia Rivers

NASA Astrophysics Data System (ADS)

Ferguson, John W.; Healey, Michael; Dugan, Patrick; Barlow, Chris

2011-01-01

We compared the effects of water resource development on migratory fish in two North American rivers using a descriptive approach based on four high-level indicators: (1) trends in abundance of Pacific salmon, (2) reliance on artificial production to maintain fisheries, (3) proportion of adult salmon that are wild- versus hatchery-origin, and (4) number of salmon populations needing federal protection to avoid extinction. The two rivers had similar biological and physical features but radically different levels of water resource development: the Fraser River has few dams and all are located in tributaries, whereas the Columbia River has more than 130 large mainstem and tributary dams. Not surprisingly, we found substantial effects of development on salmon in the Columbia River. We related the results to potential effects on migratory fish in the Mekong River where nearly 200 mainstem and tributary dams are installed, under construction, or planned and could have profound effects on its 135 migratory fish species. Impacts will vary with dam location due to differential fish production within the basin, with overall effects likely being greatest from 11 proposed mainstem dams. Minimizing impacts will require decades to design specialized fish passage facilities, dam operations, and artificial production, and is complicated by the Mekong's high diversity and productivity. Prompt action is needed by governments and fisheries managers to plan Mekong water resource development wisely to prevent impacts to the world's most productive inland fisheries, and food security and employment opportunities for millions of people in the region.

Prevalence and prognosis of stress disorders: a review of the epidemiologic literature.

PubMed

Gradus, Jaimie L

2017-01-01

Given the ubiquity of traumatic events, it is not surprising that posttraumatic stress disorder (PTSD) - a common diagnosis following one of these experiences - is characterized as conferring a large burden for individuals and society. Although there is recognition of the importance of PTSD diagnoses throughout psychiatry, the literature on other diagnoses one may receive following a stressful or traumatic event is scant. This review summarizes the literature on stress disorders (classified according to the International Classification of Diseases, 10th Edition [ICD-10]), including acute stress reaction, PTSD, adjustment disorder and unspecified stress reactions. This review focuses on the literature related to common psychiatric and somatic consequences of these disorders. The prevalence and incidence of each disorder are described. A review of epidemiologic studies on comorbid mental health conditions, including depression, anxiety and substance abuse, is included, as well as a review of epidemiologic studies on somatic outcomes, including cancer, cardiovascular disease and gastrointestinal disorders. Finally, the current literature on all-cause mortality and suicide following stress disorder diagnoses is reviewed. Stress disorders are a critical public health issue with potentially deleterious outcomes that have a significant impact on those living with these disorders, the health care system and society. It is only through an awareness of the impact of stress disorders that appropriate resources can be allocated to prevention and treatment. Future research should expand the work done to date beyond the examination of PTSD, so that the field may obtain a more complete picture of the impact all stress disorders have on the many people living with these diagnoses.

Estimating the Impact and Spillover Effect of Climate Change on Crop Yield in Northern Ghana.

NASA Astrophysics Data System (ADS)

Botchway, E.

2016-12-01

In tropical regions of the world human-induced climate change is likely to impact negatively on crop yields. To investigate the impact of climate change and its spillover effect on mean and variance of crop yields in northern Ghana, the Just and Pope stochastic production function and the Spatial Durbin model were adopted. Surprisingly, the results suggest that both precipitation and average temperature have positive effects on mean crop yield during the wet season. Wet season average temperature has a significant spillover effect in the region, whereas precipitation during the wet season has only one significant spillover effect on maize yield. Wet season precipitation does not have a strong significant effect on crop yield despite the rainfed nature of agriculture in the region. Thus, even if there are losers and winners as a result of future climate change at the regional level, future crop yield would largely depend on future technological development in agriculture, which may improve yields over time despite the changing climate. We argue, therefore, that technical improvement in farm management such as improved seeds and fertilizers, conservation tillage and better pest control, may have a more significant role in increasing observed crop productivity levels over time. So investigating the relative importance of non-climatic factors on crop yield may shed more light on where appropriate interventions can help in improving crop yields. Climate change, also, needs to be urgently assessed at the level of the household, so that poor and vulnerable people dependent on agriculture can be appropriately targeted in research and development activities whose object is poverty alleviation.

Compound flooding: examples, methods, and challenges

NASA Astrophysics Data System (ADS)

Wahl, T.

2017-12-01

When different climatic extremes occur simultaneously or in close succession, the impacts to the environment, built infrastructure and society at large are often significantly escalated. These events are collectively referred to as "compound" events. Although they are typically regarded as highly "surprising" when they occur, the dependencies and multi-scale nature of many climate phenomena mean that such events occur much more likely than might be expected by random chance alone. However, despite their high impacts, compound extremes are not, or only poorly covered in current risk analysis frameworks and policy agendas. Floods in particular, which are among the most dangerous and costly natural hazards, are rarely a function of just one driver. Rather, they often arise through the joint occurrence of different source mechanisms. This can include oceanographic drivers such as tides, storm surges, or waves, as well as hydrologic drivers such as rainfall runoff (pluvial) or river discharge (fluvial). Often, two or more of these flood drivers affect the same region and are correlated with each other, which needs to be accounted for in flood risk assessments. This presentation will briefly introduce the different types of compound flooding along with recent examples from around the globe where those high impact events led to substantial damages and loss of lives. A broad overview will be provided of existing statistical modelling tools to identify and simulate dependencies between flood drivers, for example when calculating joint probabilities. Finally, some of the most pressing challenges in developing improved strategies to assess and mitigate the risks of climatic compound extremes, and compound flooding in particular, will be discussed.

On Lack of Robustness in Hydrological Model Development Due to Absence of Guidelines for Selecting Calibration and Evaluation Data: Demonstration for Data-Driven Models

NASA Astrophysics Data System (ADS)

Zheng, Feifei; Maier, Holger R.; Wu, Wenyan; Dandy, Graeme C.; Gupta, Hoshin V.; Zhang, Tuqiao

2018-02-01

Hydrological models are used for a wide variety of engineering purposes, including streamflow forecasting and flood-risk estimation. To develop such models, it is common to allocate the available data to calibration and evaluation data subsets. Surprisingly, the issue of how this allocation can affect model evaluation performance has been largely ignored in the research literature. This paper discusses the evaluation performance bias that can arise from how available data are allocated to calibration and evaluation subsets. As a first step to assessing this issue in a statistically rigorous fashion, we present a comprehensive investigation of the influence of data allocation on the development of data-driven artificial neural network (ANN) models of streamflow. Four well-known formal data splitting methods are applied to 754 catchments from Australia and the U.S. to develop 902,483 ANN models. Results clearly show that the choice of the method used for data allocation has a significant impact on model performance, particularly for runoff data that are more highly skewed, highlighting the importance of considering the impact of data splitting when developing hydrological models. The statistical behavior of the data splitting methods investigated is discussed and guidance is offered on the selection of the most appropriate data splitting methods to achieve representative evaluation performance for streamflow data with different statistical properties. Although our results are obtained for data-driven models, they highlight the fact that this issue is likely to have a significant impact on all types of hydrological models, especially conceptual rainfall-runoff models.

The Importance of Apollo to Solar-System Science and Future Human Exploration

NASA Astrophysics Data System (ADS)

Neal, C. R.; Shearer, C. K.

2012-12-01

December 14, 2012 marks 40 years since humans walked on the Moon, and the demise of the Apollo program. Apollo will be remembered for America's response to the President's ambitious plan to go to the Moon that was fueled by cold-war "competition". However, the importance of Apollo goes far beyond that because it represents an achievement that spacefaring nations, including the USA, still aspire to. This presentation focuses on the Apollo influence on our understanding of the Moon and the Solar-System, as well as future human exploration activities. Apollo gave 2 things that continue to yield surprises and (re)shape our thinking about the Moon: ALSEP data sets and the Apollo lunar sample collection. The ALSEPs gave us data on the radiation and dust environment, as the nature of the lunar interior, and how the Moon interacts with the solar wind and Earth's magnetotail. Many of ALSEP datasets are STILL not available in the Planetary Data System, but those that are yield surprises, such as the direct detection of the Moon's core from Apollo seismic data (Weber et al., 2011, Science 331, 309). This is now possible because of the more sophisticated computing systems that are available. Apollo samples have shown the unequivocal presence of indigenous lunar water (Saal et al., 2008, Nature 454, 192). ALSEP data, Apollo samples, and the Apollo experience itself are still critical in shaping human space exploration, and showing the knowledge gaps that need to be filled to facilitate long-term human lunar exploration and beyond. ALSEP data are the only data we have regarding dust activity on the lunar surface. This coupled with the Apollo astronaut experience shows that systems (e.g., space suits) need to be engineered differently if a permanent human lunar presence is ever to be established. Seismic data show the magnitude of some moonquakes exceed 5 on the Richter scale and the maximum ground movement lasts several minutes and takes over an hour to dissipate. Any habitat should not be constructed where such an epicenter could be located. In addition, there are lunar samples that have remained unopened since there were collected, which could inform us about the volatile content and potential toxicity of the lunar regolith, as well as the technologies needed to collect, preserve and return volatile-rich samples from many planetary environments. With regard to science, Apollo allowed an absolute chronology to be developed for the impact history of the inner Solar-System. This was achieved by the return of impact melts, but their recognition within the collection initially proved difficult and detection requires destruction of a large amount of precious sample. A new, non-destructive method for identifying impact melts is presented that demonstrates Apollo samples are "the gift that keeps on giving". This involves quantitative petrography through the determination of plagioclase crystal size distributions and the relationship between the slopes and population density intercepts. Data from a study of mare basalt and impact melt crystal size distributions over several years shows lunar impact melts are distinct from mare basalts. Such a non-destructive identification of impact melt is critical for a future sample return from South Pole-Aitken Basin where impact melt is required to date the impact basin and test the late heavy bombardment hypothesis.

Human amygdala response to dynamic facial expressions of positive and negative surprise.

PubMed

Vrticka, Pascal; Lordier, Lara; Bediou, Benoît; Sander, David

2014-02-01

Although brain imaging evidence accumulates to suggest that the amygdala plays a key role in the processing of novel stimuli, only little is known about its role in processing expressed novelty conveyed by surprised faces, and even less about possible interactive encoding of novelty and valence. Those investigations that have already probed human amygdala involvement in the processing of surprised facial expressions either used static pictures displaying negative surprise (as contained in fear) or "neutral" surprise, and manipulated valence by contextually priming or subjectively associating static surprise with either negative or positive information. Therefore, it still remains unresolved how the human amygdala differentially processes dynamic surprised facial expressions displaying either positive or negative surprise. Here, we created new artificial dynamic 3-dimensional facial expressions conveying surprise with an intrinsic positive (wonderment) or negative (fear) connotation, but also intrinsic positive (joy) or negative (anxiety) emotions not containing any surprise, in addition to neutral facial displays either containing ("typical surprise" expression) or not containing ("neutral") surprise. Results showed heightened amygdala activity to faces containing positive (vs. negative) surprise, which may either correspond to a specific wonderment effect as such, or to the computation of a negative expected value prediction error. Findings are discussed in the light of data obtained from a closely matched nonsocial lottery task, which revealed overlapping activity within the left amygdala to unexpected positive outcomes. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Neptune - Changes in Great Dark Spot

NASA Technical Reports Server (NTRS)

1989-01-01

These images show changes in the clouds around Neptune's Great Dark Spot (GDS) over a four and one-half-day period. From top to bottom the images show successive rotations of the planet an interval of about 18 hours. The GDS is at a mean latitude of 20 degrees south, and covers about 30 degrees of longitude. The violet filter of the Voyager narrow angle camera was used to produce these images at distances ranging from 17 million kilometers (10.5 million miles) at the top, to 10 million kilometers (6.2 million miles) at bottom. The images have been mapped on to a rectangular latitude longitude grid to remove the effects of changing viewing geometry and the changing distance to Neptune. The sequence shows a large change in the western end (left side) of the GDS, where a dark extension apparent in the earlier images converges into an extended string of small dark spots over the next five rotations. This 'string of beads' extends from the GDS at a surprisingly large angle relative to horizontal lines of constant latitude. The large bright cloud at the southern (bottom) border of the GDS is a more or less permanent companion of the GDS. The apparent motion of smaller clouds at the periphery of the GDS suggests a counterclockwise rotation of the GDS reminiscent of flow around the Great Red Spot in Jupiter's atmosphere. This activity of the GDS is surprising because the total energy flux from the sun and from Neptune's interior is only 5 percent as large as the total energy flux on Jupiter.

Marital disruption and health insurance.

PubMed

Peters, H Elizabeth; Simon, Kosali; Taber, Jamie Rubenstein

2014-08-01

Despite the high levels of marital disruption in the United States and the fact that a significant portion of health insurance coverage for those less than age 65 is based on family membership, surprisingly little research is available on the consequences of marital disruption for the health insurance coverage of men, women, and children. We address this shortfall by examining patterns of coverage surrounding marital disruption for men, women, and children, further subset by educational level. Using the 1996, 2001, and 2004 panels of the Survey of Income and Program Participation (SIPP), we find large differences in health insurance coverage across marital status groups in the cross-section. In longitudinal analyses that focus on within-person change, we find small overall coverage changes but large changes in type of coverage following marital disruption. Both men and women show increases in private coverage in their own names, but offsetting decreases in dependent coverage tend to be larger. One surprising result is that dependent coverage for children also declines after marital dissolution, even though children are still likely to be eligible for that coverage. Children and (to a lesser extent) women show increases in public coverage around the time of divorce or separation. We also find that these patterns differ by education. The most vulnerable group appears to be lower-educated women with children because the increases in private, own-name, and public insurance are not large enough to offset the large decrease in dependent coverage. As the United States implements federal health reform, it is critical that we understand the ways in which life course events-specifically, marital disruption-shape the dynamic patterns of coverage.

Exploring the concept of climate surprises. A review of the literature on the concept of surprise and how it is related to climate change

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glantz, M.H.; Moore, C.M.; Streets, D.G.

This report examines the concept of climate surprise and its implications for environmental policymaking. Although most integrated assessment models of climate change deal with average values of change, it is usually the extreme events or surprises that cause the most damage to human health and property. Current models do not help the policymaker decide how to deal with climate surprises. This report examines the literature of surprise in many aspects of human society: psychology, military, health care, humor, agriculture, etc. It draws together various ways to consider the concept of surprise and examines different taxonomies of surprise that have beenmore » proposed. In many ways, surprise is revealed to be a subjective concept, triggered by such factors as prior experience, belief system, and level of education. How policymakers have reacted to specific instances of climate change or climate surprise in the past is considered, particularly with regard to the choices they made between proactive and reactive measures. Finally, the report discusses techniques used in the current generation of assessment models and makes suggestions as to how climate surprises might be included in future models. The report concludes that some kinds of surprises are simply unpredictable, but there are several types that could in some way be anticipated and assessed, and their negative effects forestalled.« less

Jupiter: friend or foe?

NASA Astrophysics Data System (ADS)

Horner, Jonti; Jones, Barrie W.

2008-02-01

The idea that Jupiter has shielded the Earth from potentially catastrophic impacts has long permeated the public and scientific mind. But has it shielded us? We are carrying out the first detailed examination of the degree of shielding provided by Jupiter and have obtained some surprising results. Rather than Jupiter acting as a defensive presence, we found that it actually makes little difference - but if Jupiter were significantly smaller, the impact rate experienced by the Earth would be considerably enhanced. Indeed, it seems that a giant planet in the outer reaches of a planetary system can actually pose a threat to the habitability of terrestrial worlds closer to the system's parent star.

Snow and Rain Modify Neighbourhood Walkability for Older Adults.

PubMed

Clarke, Philippa; Hirsch, Jana A; Melendez, Robert; Winters, Meghan; Sims Gould, Joanie; Ashe, Maureen; Furst, Sarah; McKay, Heather

2017-06-01

The literature has documented a positive relationship between walkable built environments and outdoor mobility in older adults. Yet, surprisingly absent is any consideration of how weather conditions modify the impact of neighbourhood walkability. Using archived weather data linked to survey data collected from a sample of older adults in Vancouver, Canada, we found that car-dependent neighbourhoods (featuring longer block lengths, fewer intersections, and greater distance to amenities) became inaccessible in snow. Even older adults who lived in very walkable neighbourhoods walked to 25 per cent fewer destinations in snow. It is crucial to consider the impact of weather in the relationship between neighbourhood walkability and older adult mobility.

Corrugator activity confirms immediate negative affect in surprise

PubMed Central

Topolinski, Sascha; Strack, Fritz

2015-01-01

The emotion of surprise entails a complex of immediate responses, such as cognitive interruption, attention allocation to, and more systematic processing of the surprising stimulus. All these processes serve the ultimate function to increase processing depth and thus cognitively master the surprising stimulus. The present account introduces phasic negative affect as the underlying mechanism responsible for this switch in operating mode. Surprising stimuli are schema-discrepant and thus entail cognitive disfluency, which elicits immediate negative affect. This affect in turn works like a phasic cognitive tuning switching the current processing mode from more automatic and heuristic to more systematic and reflective processing. Directly testing the initial elicitation of negative affect by surprising events, the present experiment presented high and low surprising neutral trivia statements to N = 28 participants while assessing their spontaneous facial expressions via facial electromyography. High compared to low surprising trivia elicited higher corrugator activity, indicative of negative affect and mental effort, while leaving zygomaticus (positive affect) and frontalis (cultural surprise expression) activity unaffected. Future research shall investigate the mediating role of negative affect in eliciting surprise-related outcomes. PMID:25762956

Corrugator activity confirms immediate negative affect in surprise.

PubMed

Topolinski, Sascha; Strack, Fritz

2015-01-01

The emotion of surprise entails a complex of immediate responses, such as cognitive interruption, attention allocation to, and more systematic processing of the surprising stimulus. All these processes serve the ultimate function to increase processing depth and thus cognitively master the surprising stimulus. The present account introduces phasic negative affect as the underlying mechanism responsible for this switch in operating mode. Surprising stimuli are schema-discrepant and thus entail cognitive disfluency, which elicits immediate negative affect. This affect in turn works like a phasic cognitive tuning switching the current processing mode from more automatic and heuristic to more systematic and reflective processing. Directly testing the initial elicitation of negative affect by surprising events, the present experiment presented high and low surprising neutral trivia statements to N = 28 participants while assessing their spontaneous facial expressions via facial electromyography. High compared to low surprising trivia elicited higher corrugator activity, indicative of negative affect and mental effort, while leaving zygomaticus (positive affect) and frontalis (cultural surprise expression) activity unaffected. Future research shall investigate the mediating role of negative affect in eliciting surprise-related outcomes.

Effect of interfacial turbulence and accommodation coefficient on CFD predictions of pressurization and pressure control in cryogenic storage tank

NASA Astrophysics Data System (ADS)

Kassemi, Mohammad; Kartuzova, Olga

2016-03-01

Pressurization and pressure control in cryogenic storage tanks are to a large extent affected by heat and mass transport across the liquid-vapor interface. These mechanisms are, in turn, controlled by the kinetics of the phase change process and the dynamics of the turbulent recirculating flows in the liquid and vapor phases. In this paper, the effects of accommodation coefficient and interfacial turbulence on tank pressurization and pressure control simulations are examined. Comparison between numerical predictions and ground-based measurements in two large liquid hydrogen tank experiments, performed in the K-site facility at NASA Glenn Research Center (GRC) and the Multi-purpose Hydrogen Test Bed (MHTB) facility at NASA Marshall Space Flight Center (MSFC), are used to show the impact of accommodation coefficient and interfacial and vapor phase turbulence on evolution of pressure and temperatures in the cryogenic storage tanks. In particular, the self-pressurization comparisons indicate that: (1) numerical predictions are essentially independent of the magnitude of the accommodation coefficient; and (2) surprisingly, laminar models sometimes provide results that are in better agreement with experimental self-pressurization rates, even in parametric ranges where the bulk flow is deemed fully turbulent. In this light, shortcomings of the present CFD models, especially, numerical treatments of interfacial mass transfer and turbulence, as coupled to the Volume-of-Fluid (VOF) interface capturing scheme, are underscored and discussed.

Using selection bias to explain the observed structure of Internet diffusions

PubMed Central

Golub, Benjamin; Jackson, Matthew O.

2010-01-01

Recently, large datasets stored on the Internet have enabled the analysis of processes, such as large-scale diffusions of information, at new levels of detail. In a recent study, Liben-Nowell and Kleinberg [(2008) Proc Natl Acad Sci USA 105:4633–4638] observed that the flow of information on the Internet exhibits surprising patterns whereby a chain letter reaches its typical recipient through long paths of hundreds of intermediaries. We show that a basic Galton–Watson epidemic model combined with the selection bias of observing only large diffusions suffices to explain these patterns. Thus, selection biases of which data we observe can radically change the estimation of classical diffusion processes. PMID:20534439

Surprise disrupts cognition via a fronto-basal ganglia suppressive mechanism

PubMed Central

Wessel, Jan R.; Jenkinson, Ned; Brittain, John-Stuart; Voets, Sarah H. E. M.; Aziz, Tipu Z.; Aron, Adam R.

2016-01-01

Surprising events markedly affect behaviour and cognition, yet the underlying mechanism is unclear. Surprise recruits a brain mechanism that globally suppresses motor activity, ostensibly via the subthalamic nucleus (STN) of the basal ganglia. Here, we tested whether this suppressive mechanism extends beyond skeletomotor suppression and also affects cognition (here, verbal working memory, WM). We recorded scalp-EEG (electrophysiology) in healthy participants and STN local field potentials in Parkinson's patients during a task in which surprise disrupted WM. For scalp-EEG, surprising events engage the same independent neural signal component that indexes action stopping in a stop-signal task. Importantly, the degree of this recruitment mediates surprise-related WM decrements. Intracranially, STN activity is also increased post surprise, especially when WM is interrupted. These results suggest that surprise interrupts cognition via the same fronto-basal ganglia mechanism that interrupts action. This motivates a new neural theory of how cognition is interrupted, and how distraction arises after surprising events. PMID:27088156

Kramers degeneracy and relaxation in vanadium, niobium and tantalum clusters

NASA Astrophysics Data System (ADS)

Diaz-Bachs, A.; Katsnelson, M. I.; Kirilyuk, A.

2018-04-01

In this work we use magnetic deflection of V, Nb, and Ta atomic clusters to measure their magnetic moments. While only a few of the clusters show weak magnetism, all odd-numbered clusters deflect due to the presence of a single unpaired electron. Surprisingly, for the majority of V and Nb clusters an atomic-like behavior is found, which is a direct indication of the absence of spin–lattice interaction. This is in agreement with Kramers degeneracy theorem for systems with a half-integer spin. This purely quantum phenomenon is surprisingly observed for large systems of more than 20 atoms, and also indicates various quantum relaxation processes, via Raman two-phonon and Orbach high-spin mechanisms. In heavier, Ta clusters, the relaxation is always present, probably due to larger masses and thus lower phonon energies, as well as increased spin–orbit coupling.

Balancing measures or a balanced accounting of improvement impact: a qualitative analysis of individual and focus group interviews with improvement experts in Scotland.

PubMed

Toma, Madalina; Dreischulte, Tobias; Gray, Nicola M; Campbell, Diane; Guthrie, Bruce

2018-07-01

As quality improvement (QI) programmes have become progressively larger scale, the risks of implementation having unintended consequences are increasingly recognised. More routine use of balancing measures to monitor unintended consequences has been proposed to evaluate overall effectiveness, but in practice published improvement interventions hardly ever report identification or measurement of consequences other than intended goals of improvement. We conducted 15 semistructured interviews and two focus groups with 24 improvement experts to explore the current understanding of balancing measures in QI and inform a more balanced accounting of the overall impact of improvement interventions. Data were analysed iteratively using the framework approach. Participants described the consequences of improvement in terms of desirability/undesirability and the extent to which they were expected/unexpected when planning improvement. Four types of consequences were defined: expected desirable consequences ( goals ); expected undesirable consequences ( trade-offs ); unexpected undesirable consequences ( unpleasant surprises ); and unexpected desirable consequences ( pleasant surprises ). Unexpected consequences were considered important but rarely measured in existing programmes, and an improvement pause to take stock after implementation would allow these to be more actively identified and managed. A balanced accounting of all consequences of improvement interventions can facilitate staff engagement and reduce resistance to change, but has to be offset against the cost of additional data collection. Improvement measurement is usually focused on measuring intended goals , with minimal use of balancing measures which when used, typically monitor trade-offs expected before implementation. This paper proposes that improvers and leaders should seek a balanced accounting of all consequences of improvement across the life of an improvement programme, including deliberately pausing after implementation to identify and quantitatively or qualitatively evaluate any pleasant or unpleasant surprises. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Comparative study of isotopic trends in two coastal ecosystems of North Biscay: A multitrophic spatial gradient approach

NASA Astrophysics Data System (ADS)

Mortillaro, J. M.; Schaal, G.; Grall, J.; Nerot, C.; Brind'Amour, A.; Marchais, V.; Perdriau, M.; Le Bris, H.

2014-01-01

In coastal estuarine embayments, retention of water masses due to coastal topography may result in an increased contribution of continental organic matter in food webs. However, in megatidal embayments, the effect of topography can be counterbalanced by the process of tidal mixing. Large amounts of continental organic matter are exported each year by rivers to the oceans. The fate of terrestrial organic matter in food webs of coastal areas and on neighboring coastal benthic communities was therefore evaluated, at multi-trophic levels, from primary producers to primary consumers and predators. Two coastal areas of the French Atlantic coast, differing in the contributions from their watershed, tidal range and aperture degree, were compared using carbon and nitrogen stable isotopes (δ13C and δ15N) during two contrasted periods. The Bay of Vilaine receives large inputs of freshwater from the Vilaine River, displaying 15N enriched and 13C depleted benthic communities, emphasizing the important role played by allochtonous inputs and anthropogenic impact on terrestrial organic matter in the food web. In contrast, the Bay of Brest which is largely affected by tidal mixing, showed a lack of agreement between isotopic gradients displayed by suspended particulate organic matter (SPOM) and suspension-feeders. Discrepancy between SPOM and suspension-feeders is not surprising due to differences in isotopes integration times. We suggest further that such a discrepancy may result from water replenishment due to coastal inputs, nutrient depletion by phytoplankton production, as well as efficient selection of highly nutritive phytoplanktonic particles by primary consumers.

[Epidemiological methods used in studies in the prevalence of Tourette syndrome].

PubMed

Stefanoff, Paweł; Mazurek, Jacek

2003-01-01

Tourette syndrome (TS) prevalence was studied since the early 80-ies. Its clinical course is characterised by co-occurrence of motor and vocal tics. Results of previous epidemiological studies were surprisingly divergent: the prevalence varied from 0.5 to 115 cases per 10,000 population. The disease previously recognised as extremely rare and severe is now considered as quite common, with often moderate course. Selected methods used in studies of TS prevalence and analysis of their possible impact on study results are presented. The studies were divided into 3 groups: studies of the hospitalised population, large-scale screenings and studies involving school population, basing on characteristic and size of population, methods of selection of subjects, diagnostic and screening methods used. Studies of the hospitalised population involved patients with most severe symptoms, in different age groups, different methods of final diagnosis confirmation were used. TS prevalence varied from 0.5 up to 15 cases per 10,000 population. Procedures used in large-scale screening studies made possible the elimination of potential selection bias. Large populations were studied using transparent and repetitive confirmation of diagnoses. Their validity was additionally checked in parallel validity studies. TS prevalence was in the range 4.3 to 10 cases per 10,000 population. The highest TS prevalence was obtained in studies involving schoolchildren. Data were gathered from multiple sources: from parents, teachers and children, as well as from classroom observation. Diagnoses were made by experienced clinicians. TS prevalence obtained in school population studies was between 36.2 up to 115 per 10,000 population.

Scaling behavior in the dynamics of citations to scientific journals

NASA Astrophysics Data System (ADS)

Picoli, S., Jr.; Mendes, R. S.; Malacarne, L. C.; Lenzi, E. K.

2006-08-01

We analyze a database comprising the impact factor (citations per recent items published) of scientific journals for a 13-year period (1992 2004). We find that i) the distribution of impact factors follows asymptotic power law behavior, ii) the distribution of annual logarithmic growth rates has an exponential form, and iii) the width of this distribution decays with the impact factor as a power law with exponent β simeq 0.22. The results ii) and iii) are surprising similar to those observed in the growth dynamics of organizations with complex internal structure suggesting the existence of common mechanisms underlying the dynamics of these systems. We propose a general model for such systems, an extension of the simplest model for firm growth, and compare their predictions with our empirical results.

Measurement of the Mass of an Object Hanging from a Spring--Revisited

ERIC Educational Resources Information Center

Serafin, Kamil; Oracz, Joanna; Grzybowski, Marcin; Koperski, Maciej; Sznajder, Pawel; Zinkiewicz, Lukasz; Wasylczyk, Piotr

2012-01-01

In an open competition, students were to determine the mass of a metal cylinder hanging on a spring inside a transparent enclosure. With the time for experiments limited to 24 h due to the unexpectedly large number of participants, a few surprisingly accurate results were submitted, the best of them differing by no more than 0.5% from the true…

Low Temperature Regenerator Study.

DTIC Science & Technology

1979-08-01

ultrafine particles in the regenerator matrix, he must increase the gross refrigeration to overcome the poorer efficiency of conventional materials. The...well as being, in many cases, highly toxic. 4.2 Production of Particles There are a surprisingly large number of ways that ultrafine particles can be...however, those materials provide some evidence that the surface enhance- ment effect survives when ultrafine particles are embedded, and even alloyed

Thermal cover needs of large ungulates: a review of hypothesis tests.

Treesearch

John G. Cook; Larry L. Irwin; Larry D. Bryant; Robert A. Riggs; Jack Ward Thomas

2004-01-01

A great deal of big game research occurred in western North America during the 1960s through the 1980s, and many advances in our knowledge occurred as a result. Timber harvest increased during this period in many localities, and this trend was often perceived to threaten ungulate populations (Hieb 1976). Thus, it is not surprising that appreciable research in this era...

A Vision for High Schools: Joining Academic and Technical Studies to Promote More Powerful Learning

ERIC Educational Resources Information Center

Bottoms, Gene

2008-01-01

One in four American students does not graduate from high school on time, if at all. Many of these young people blame schoolwork that failed to challenge them and assignments that meant nothing in their lives. More surprising are the large numbers of students who graduate from high school and enter college but do not receive a degree. They drop…

Large Quantum Probability Backflow and the Azimuthal Angle-Angular Momentum Uncertainty Relation for an Electron in a Constant Magnetic Field

ERIC Educational Resources Information Center

Strange, P.

2012-01-01

In this paper we demonstrate a surprising aspect of quantum mechanics that is accessible to an undergraduate student. We discuss probability backflow for an electron in a constant magnetic field. It is shown that even for a wavepacket composed entirely of states with negative angular momentum the effective angular momentum can take on positive…

Duration of psychotherapy has little association with outcome.

PubMed

King, Michael

2015-08-01

Does more psychotherapy deliver better outcomes? The answer to this question has important implications for patients' lives and costs to society. This issue of the BJPsych contains an analysis of data from a large clinical cohort receiving courses of talking therapy of up to 40 sessions in length. Duration of therapy was inversely correlated with outcome. Should we be surprised? © The Royal College of Psychiatrists 2015.

What Really Happened to Earth's Older Craters?

NASA Astrophysics Data System (ADS)

Bottke, William; Mazrouei, Sara; Ghent, Rebecca; Parker, Alex

2017-10-01

Most assume the Earth’s crater record is heavily biased, with erosion/tectonics destroying older craters. This matches expectations, but is it actually true? To test this idea, we compared Earth’s crater record, where nearly all D ≥ 20 km craters are < 650 Myr old, to the Moon’s. Here lunar crater ages were computed using a new method employing LRO-Diviner temperature data. Large lunar rocks have high thermal inertia and remain warm through the night relative to the regolith. Analysis shows young craters with numerous meter-sized fragments are easy to pick out from older craters with eroded fragments. Moreover, an inverse relationship between rock abundance (RA) and crater age exists. Using measured RA values, we computed ages for 111 rocky craters with D ≥ 10 km that formed between 80°N and 80°S over the last 1 Gyr.We found several surprising results. First, the production rate of D ≥ 10 km lunar craters increased by a factor of 2.2 [-0.9, +4.4; 95% confidence limits] over the past 250 Myr compared to the previous 750 Myr. Thus, the NEO population is higher now than it has been for the last billion years. Second, the size and age distributions of lunar and terrestrial craters for D ≥ 20 km over the last 650 Myr have similar shapes. This implies that crater erasure must be limited on stable terrestrial terrains; in an average sense, for a given region, the Earth either keeps all or loses all of its D ≥ 20 craters at the same rate, independent of size. It also implies the observed deficit of large terrestrial craters between 250-650 Myr is not preservation bias but rather reflects a distinctly lower impact flux. We predict 355 ± 86 D ≥ 20 km craters formed on Earth over the last 650 Myr. Only 38 ± 6 are known, so the ratio, 10.7 ± 3.1%, is a measure of the Earth’s surface that is reasonably stable to large crater formation over 650 Myr. If erosion had dominated, the age distribution of terrestrial craters would be strongly skewed toward younger ages, which is not observed. We predict Chicxulub-type impacts were rare over the last Gyr, with the event 66 Ma a probable byproduct of the current high terrestrial impact flux.

Skating on a Film of Air: Drops Impacting on a Surface

NASA Astrophysics Data System (ADS)

Kolinski, John M.; Rubinstein, Shmuel M.; Mandre, Shreyas; Brenner, Michael P.; Weitz, David A.; Mahadevan, L.

2012-02-01

The commonly accepted description of drops impacting on a surface typically ignores the essential role of the air that is trapped between the impacting drop and the surface. Here we describe a new imaging modality that is sensitive to the behavior right at the surface. We show that a very thin film of air, only a few tens of nanometers thick, remains trapped between the falling drop and the surface as the drop spreads. The thin film of air serves to lubricate the drop enabling the fluid to skate on the air film laterally outward at surprisingly high velocities, consistent with theoretical predictions. Eventually this thin film of air breaks down as the fluid wets the surface via a spinodal-like mechanism. Our results show that the dynamics of impacting drops are much more complex than previously thought, with a rich array of unexpected phenomena that require rethinking classic paradigms.

From pen pals to chat rooms: the impact of social media on Middle Eastern Society.

PubMed

Hatfield, Elaine; Rapson, Richard L

2015-01-01

In this article, we will discuss what is known about a surprisingly popular phenomenon in the Middle East-the use of social media to communicate. We will begin with a discussion of what "social media" sites are (sites such as Facebook, Your Middle East, YouTube, Flickr, Muslima.com, chat rooms, and instant messaging) and point out how common they are in the Middle East. Next, we will discuss the reasons why men and women are currently using Internet and social media. Finally, we will discuss what impact social media have had on politics, political dissent, education, and men's and women's relationships-and the impact they might be expected to have in future years. Finally, we will focus on the impact of such media on men's and women's relationships-including cross-gender friendships, romantic relationships, and sexual relationships.

Using demographics to predict smoking behavior: large sample evidence from an emerging market.

PubMed

Prinsloo, Melani; Tudhope, Lynne; Pitt, Leyland; Campbell, Colin

2008-01-01

Smoking and nicotine addiction are among the major preventable causes of disease and mortality. Being able to target promotional campaigns effectively relies on a good understanding of the demographics of smokers and potential smokers. This study reports on the results of a large sample survey of the demographics of smokers and non-smokers in South African townships. Using logistical regression, it finds that smokers tend to be significantly, older males who are less educated, and somewhat surprisingly, with no religious affiliation. Implications for public health policy are identified, and avenues for future research recognized.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, L. W.; Franceschetti, A.; Zunger, A.

We have developed a "linear combination of bulk bands" method that permits atomistic, pseudopotential electronic structure calculations for .apprx.10(sup6) atom nanostructures. Application to (GaAs)n/A1As)n (001) superlattices (SL's) reveals even-odd oscillations in the ..Gamma..-X coupling magnitude Vrx(n), which vanishes for n = odd, even for abrupt and segregated SL's, respectively. Surprisingly, in contrast with recent expectations, OD quantum dots are found here to have a smaller ..Gamma..-X coupling than equivalent 2D SL's. Our analysis shows that for large quantum dots this is largely due to the existence of level repulsion from many X states.

Well, slap my thigh: expression of surprise facilitates memory of surprising material.

PubMed

Parzuchowski, Michal; Szymkow-Sudziarska, Aleksandra

2008-06-01

Two studies examined the general prediction that one's emotional expression should facilitate memory for material that matches the expression. The authors focused on specific facial expressions of surprise. In the first study, participants who were mimicking a surprised expression showed better recall for the surprising words and worse recall for neutral words, relative to those who were mimicking a neutral expression. Study 2 replicated the results of Study 1, showing that participants who mimicked a surprised expression recalled more words spoken in a surprising manner compared with those that sounded neutral or sad. Conversely, participants who mimicked sad facial expressions showed greater recall for sad than neutral or surprising words. The results provide evidence of the importance of matching the emotional valence of the recall content to the facial expression of the recaller during the memorization period. (PsycINFO Database Record (c) 2008 APA, all rights reserved). (Copyright) 2008 APA, all rights reserved.

Infrastructure Tsunami Could Easily Dwarf Climate Change

NASA Astrophysics Data System (ADS)

Lansing, Stephen

Compared to the physical and biological sciences, so far complexity has had far less impact on mainstream social science. This is not surprising, but it is alarming because we find ourselves in the midst of a planetary-scale transition from the Holocene to the Anthropocene. We have already breached some planetary boundaries for sustainability, but those tipping points are nearly invisible from the perspective of the linear equilibrium models that continue to hold sway in social science...

Improving the Small-Business Role in Turkish Defense Acquisitions: Recommendations from U.S. Best Practices

DTIC Science & Technology

2010-06-01

not take into account the effects of the Global Crisis as it impacts the small business assistance programs. Data related to Small and Medium Sized...unanticipated by many scholars and members of the policy community , but what was even more surprising than the resurgence itself was the primary...innovative because of their responsiveness to “changing market demands,” flexible structures, and “efficient internal communication ” (Mogee, 2003, p. 3

Proposed Legislative Changes to the Post-9/11 GI Bill: Potential Implications for Veterans and Colleges. Policy Matters: A Higher Education Policy Brief

ERIC Educational Resources Information Center

McBain, Lesley

2010-01-01

As the Post-9/11 Veterans Education Assistance Act (popularly known as the Post-9/11 GI Bill or Chapter 33) begins its second academic year of operation, changes loom on the horizon. While this is no surprise to those who know the history of the original GI Bill, some of the changes will have considerable impact not only on veteran students, but…

Insuring influence: Annual ranking of healthcare's 100 Most Influential shows big impact of health coverage issues in America, from policy to business to politics.

PubMed

Robeznieks, Andis

2012-08-27

It was a year of surprises on the 100 Most Influential People in Healthcare ranking, with the top three all being newcomers. The top 10 was dominated by players in government and the insurance business, spheres where reform is driving the agenda. "We are not waiting for reform to happen, we are leading the change," says No. 2 Mark Bertolini, of Aetna.

Abrupt Impacts of Climate Change: Anticipating Surprises

NASA Astrophysics Data System (ADS)

White, James W. C.; Alley, Richard B.; Archer, David E.; Barnosky, Anthony D.; Dunlea, Edward; Foley, Jonathan; Fu, Rong; Holland, Marika M.; Lozier, M. Susan; Schmitt, Johanna; Smith, Laurence C.; Sugihara, George; Thompson, David W. J.; Weaver, Andrew J.; Wofsy, Steven C.

2014-05-01

Levels of carbon dioxide and other greenhouse gases in Earth's atmosphere are exceeding levels recorded in the past millions of years, and thus climate is being forced beyond the range of the recent geological era. Lacking concerted action by the world's nations, it is clear that the future climate will be warmer, sea levels will rise, global rainfall patterns will change, and ecosystems will be altered. However, there is still uncertainty about how we will arrive at that future climate state. Although many projections of future climatic conditions have predicted steadily changing conditions giving the impression that communities have time to gradually adapt, the scientific community has been paying increasing attention to the possibility that at least some changes will be abrupt, perhaps crossing a threshold or "tipping point" to change so quickly that there will be little time to react. This presentation will synopsize the new US National Research Council Report, Abrupt Impacts of Climate Change: Anticipating Surprises, highlighting areas of increased and decreased concern, as well as areas of new concern. Emphasis is placed on not only abrupt change in physical climate, but on abrupt changes in human and natural systems that can occur as a result of a slowly changing climate. The report calls for action now on an abrupt change early warning system (ACEWS) if societies are to be resilient to climate change.

The impact of oil price on Malaysian sector indices

NASA Astrophysics Data System (ADS)

Ismail, Mohd Tahir; Luan, Yeap Pei; Ee, Ong Joo

2015-12-01

In this paper, vector error correction model (VECM) has been utilized to model the dynamic relationships between world crude oil price and the sector indices of Malaysia. The sector indices have been collected are covering the period Jan 1998 to Dec 2013. Surprisingly, our investigations show that oil price changes do not Granger-cause any of the sectors in all of Malaysia. However, sector indices of Food Producer and Utilities are found to be the cause of the changes in world crude oil prices. Furthermore, from the results of variance decomposition, very high percentage of shocks is explained by world crude oil price itself over the 12 months and small impact from other sector indices.

Granular impact cratering by liquid drops: Understanding raindrop imprints through an analogy to asteroid strikes

PubMed Central

Zhao, Runchen; Zhang, Qianyun; Tjugito, Hendro; Cheng, Xiang

2015-01-01

When a granular material is impacted by a sphere, its surface deforms like a liquid yet it preserves a circular crater like a solid. Although the mechanism of granular impact cratering by solid spheres is well explored, our knowledge on granular impact cratering by liquid drops is still very limited. Here, by combining high-speed photography with high-precision laser profilometry, we investigate liquid-drop impact dynamics on granular surface and monitor the morphology of resulting impact craters. Surprisingly, we find that despite the enormous energy and length difference, granular impact cratering by liquid drops follows the same energy scaling and reproduces the same crater morphology as that of asteroid impact craters. Inspired by this similarity, we integrate the physical insight from planetary sciences, the liquid marble model from fluid mechanics, and the concept of jamming transition from granular physics into a simple theoretical framework that quantitatively describes all of the main features of liquid-drop imprints in granular media. Our study sheds light on the mechanisms governing raindrop impacts on granular surfaces and reveals a remarkable analogy between familiar phenomena of raining and catastrophic asteroid strikes. PMID:25548187

Position Matters: Network Centrality Considerably Impacts Rates of Protein Evolution in the Human Protein–Protein Interaction Network

PubMed Central

Feyertag, Felix; Chakraborty, Sandip

2017-01-01

Abstract The proteins of any organism evolve at disparate rates. A long list of factors affecting rates of protein evolution have been identified. However, the relative importance of each factor in determining rates of protein evolution remains unresolved. The prevailing view is that evolutionary rates are dominantly determined by gene expression, and that other factors such as network centrality have only a marginal effect, if any. However, this view is largely based on analyses in yeasts, and accurately measuring the importance of the determinants of rates of protein evolution is complicated by the fact that the different factors are often correlated with each other, and by the relatively poor quality of available functional genomics data sets. Here, we use correlation, partial correlation and principal component regression analyses to measure the contributions of several factors to the variability of the rates of evolution of human proteins. For this purpose, we analyzed the entire human protein–protein interaction data set and the human signal transduction network—a network data set of exceptionally high quality, obtained by manual curation, which is expected to be virtually free from false positives. In contrast with the prevailing view, we observe that network centrality (measured as the number of physical and nonphysical interactions, betweenness, and closeness) has a considerable impact on rates of protein evolution. Surprisingly, the impact of centrality on rates of protein evolution seems to be comparable, or even superior according to some analyses, to that of gene expression. Our observations seem to be independent of potentially confounding factors and from the limitations (biases and errors) of interactomic data sets. PMID:28854629

Position Matters: Network Centrality Considerably Impacts Rates of Protein Evolution in the Human Protein-Protein Interaction Network.

PubMed

Alvarez-Ponce, David; Feyertag, Felix; Chakraborty, Sandip

2017-06-01

The proteins of any organism evolve at disparate rates. A long list of factors affecting rates of protein evolution have been identified. However, the relative importance of each factor in determining rates of protein evolution remains unresolved. The prevailing view is that evolutionary rates are dominantly determined by gene expression, and that other factors such as network centrality have only a marginal effect, if any. However, this view is largely based on analyses in yeasts, and accurately measuring the importance of the determinants of rates of protein evolution is complicated by the fact that the different factors are often correlated with each other, and by the relatively poor quality of available functional genomics data sets. Here, we use correlation, partial correlation and principal component regression analyses to measure the contributions of several factors to the variability of the rates of evolution of human proteins. For this purpose, we analyzed the entire human protein-protein interaction data set and the human signal transduction network-a network data set of exceptionally high quality, obtained by manual curation, which is expected to be virtually free from false positives. In contrast with the prevailing view, we observe that network centrality (measured as the number of physical and nonphysical interactions, betweenness, and closeness) has a considerable impact on rates of protein evolution. Surprisingly, the impact of centrality on rates of protein evolution seems to be comparable, or even superior according to some analyses, to that of gene expression. Our observations seem to be independent of potentially confounding factors and from the limitations (biases and errors) of interactomic data sets. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Probing the nanoscale with high-speed interferometry of an impacting drop

NASA Astrophysics Data System (ADS)

Thoroddsen, S. T.; Li, E. Q.; Vakarelski, I. U.; Langley, K.

2017-02-01

The simple phenomenon of a water drop falling onto a glass plate may seem like a trivial fluid mechanics problem. However, detailed imaging has shown that this process is highly complex and a small air-bubble is always entrapped under the drop when it makes contact with the solid. This bubble can interfere with the uniformity of spray coatings and degrade inkjet fabrication of displays etc. We will describe how we use high-speed interferometry at 5 million frames per second to understand the details of this process. As the impacting drop approaches the solid, the dynamics are characterized by a balance between the lubrication pressure in the thin air layer and the inertia of the bot-tom of the drop. This deforms the drop, forming a dimple at its bottom and making the drop touch the surface along a ring, thereby entrapping the air-layer, which is typically 1-3 μm thick. This air-layer can be highly compressed and the deceleration of the bottom of the drop can be as large as 300,000 g. We describe how the thickness evolution of the lubricating air-layer is extracted from following the interference fringes between frames. Two-color interferometry is also used to extract absolute layer thicknesses. Finally, we identify the effects of nanometric surface roughness on the first contact of the drop with the substrate. Here we need to resolve the 100 nm thickness changes occurring during 200 ns intervals, requiring these state of the art high-speed cameras. Surprisingly, we see a ring of micro-bubbles marking the first contact of the drop with the glass, only for microscope slides, which have a typical roughness of 20 nm, while such rings are absent for drop impacts onto molecularly smooth mica surfaces.

Some Surprising Introductory Physics Facts and Numbers

ERIC Educational Resources Information Center

Mallmann, A. James

2016-01-01

In the entertainment world, people usually like, and find memorable, novels, short stories, and movies with surprise endings. This suggests that classroom teachers might want to present to their students examples of surprising facts associated with principles of physics. Possible benefits of finding surprising facts about principles of physics are…

Sustainable Land Management's potential for climate change adaptation in Mediterranean environments: a regional scale assessment

NASA Astrophysics Data System (ADS)

Eekhout, Joris P. C.; de Vente, Joris

2017-04-01

Climate change has strong implications for many essential ecosystem services, such as provision of drinking and irrigation water, soil erosion and flood control. Especially large impacts are expected in the Mediterranean, already characterised by frequent floods and droughts. The projected higher frequency of extreme weather events under climate change will lead to an increase of plant water stress, reservoir inflow and sediment yield. Sustainable Land Management (SLM) practices are increasingly promoted as climate change adaptation strategy and to increase resilience against extreme events. However, there is surprisingly little known about their impacts and trade-offs on ecosystem services at regional scales. The aim of this research is to provide insight in the potential of SLM for climate change adaptation, focusing on catchment-scale impacts on soil and water resources. We applied a spatially distributed hydrological model (SPHY), coupled with an erosion model (MUSLE) to the Segura River catchment (15,978 km2) in SE Spain. We run the model for three periods: one reference (1981-2000) and two future scenarios (2031-2050 and 2081-2100). Climate input data for the future scenarios were based on output from 9 Regional Climate Models and for different emission scenarios (RCP 4.5 and RCP 8.5). Realistic scenarios of SLM practices were developed based on a local stakeholder consultation process. The evaluated SLM scenarios focussed on reduced tillage and organic amendments under tree and cereal crops, covering 24% and 15% of the catchment, respectively. In the reference scenario, implementation of SLM at the field-scale led to an increase of the infiltration capacity of the soil and a reduction of surface runoff up to 29%, eventually reducing catchment-scale reservoir inflow by 6%. This led to a reduction of field-scale sediment yield of more than 50% and a reduced catchment-scale sediment flux to reservoirs of 5%. SLM was able to fully mitigate the effect of climate change at the field-scale and partly at the catchment-scale. Therefore, we conclude that large-scale adoption of SLM can effectively contribute to climate change adaptation by increasing the soil infiltration capacity, the soil water retention capacity and soil moisture content in the rootzone, leading to less crop stress. These findings of regional scale impacts of SLM are of high relevance for land-owners, -managers and policy makers to design effective climate change adaptation strategies.

Irreversible muscle damage in bodybuilding due to long-term intramuscular oil injection.

PubMed

Banke, I J; Prodinger, P M; Waldt, S; Weirich, G; Holzapfel, B M; Gradinger, R; Rechl, H

2012-10-01

Intramuscular oil injections generating slowly degrading oil-based depots represent a controversial subject in bodybuilding and fitness. However they seem to be commonly reported in a large number of non-medical reports, movies and application protocols for 'site-injections'. Surprisingly the impact of long-term (ab)use on the musculature as well as potential side-effects compromising health and sports ability are lacking in the medical literature. We present the case of a 40 year old male semi-professional bodybuilder with systemic infection and painful reddened swellings of the right upper arm forcing him to discontinue weightlifting. Over the last 8 years he daily self-injected sterilized sesame seed oil at numerous intramuscular locations for the purpose of massive muscle building. Whole body MRI showed more than 100 intramuscular rather than subcutaneous oil cysts and loss of normal muscle anatomy. 2-step septic surgery of the right upper arm revealed pus-filled cystic scar tissue with the near-complete absence of normal muscle. MRI 1 year later revealed the absence of relevant muscle regeneration. Persistent pain and inability to perform normal weight training were evident for at least 3 years post-surgery. This alarming finding indicating irreversible muscle mutilation may hopefully discourage people interested in bodybuilding and fitness from oil-injections. The impact of such chronic tissue stress on other diseases like malignancy remains to be determined. © Georg Thieme Verlag KG Stuttgart · New York.

Herpes Simplex Virus 2 Infection Impacts Stress Granule Accumulation

PubMed Central

Finnen, Renée L.; Pangka, Kyle R.

2012-01-01

Interference with stress granule (SG) accumulation is gaining increased appreciation as a common strategy used by diverse viruses to facilitate their replication and to cope with translational arrest. Here, we examined the impact of infection by herpes simplex virus 2 (HSV-2) on SG accumulation by monitoring the localization of the SG components T cell internal antigen 1 (TIA-1), Ras-GTPase-activating SH3-domain-binding protein (G3BP), and poly(A)-binding protein (PABP). Our results indicate that SGs do not accumulate in HSV-2-infected cells and that HSV-2 can interfere with arsenite-induced SG accumulation early after infection. Surprisingly, SG accumulation was inhibited despite increased phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), implying that HSV-2 encodes previously unrecognized activities designed to maintain translation initiation downstream of eIF2α. SG accumulation was not inhibited in HSV-2-infected cells treated with pateamine A, an inducer that works independently of eIF2α phosphorylation. The SGs that accumulated following pateamine A treatment of infected cells contained G3BP and PABP but were largely devoid of TIA-1. We also identified novel nuclear structures containing TIA-1 that form late in infection. These structures contain the RNA binding protein 68-kDa Src-associated in mitosis (Sam68) and were noticeably absent in infected cells treated with inhibitors of viral DNA replication, suggesting that they arise as a result of late events in the virus replicative cycle. PMID:22623775

Marine Mammal Impacts in Exploited Ecosystems: Would Large Scale Culling Benefit Fisheries?

PubMed Central

Morissette, Lyne; Christensen, Villy; Pauly, Daniel

2012-01-01

Competition between marine mammals and fisheries for marine resources—whether real or perceived—has become a major issue for several countries and in international fora. We examined trophic interactions between marine mammals and fisheries based on a resource overlap index, using seven Ecopath models including marine mammal groups. On a global scale, most food consumed by marine mammals consisted of prey types that were not the main target of fisheries. For each ecosystem, the primary production required (PPR) to sustain marine mammals was less than half the PPR to sustain fisheries catches. We also developed an index representing the mean trophic level of marine mammal's consumption (TLQ) and compared it with the mean trophic level of fisheries' catches (TLC). Our results showed that overall TLQ was lower than TLC (2.88 versus 3.42). As fisheries increasingly exploit lower-trophic level species, the competition with marine mammals may become more important. We used mixed trophic impact analysis to evaluate indirect trophic effects of marine mammals, and in some cases found beneficial effects on some prey. Finally, we assessed the change in the trophic structure of an ecosystem after a simulated extirpation of marine mammal populations. We found that this lead to alterations in the structure of the ecosystems, and that there was no clear and direct relationship between marine mammals' predation and the potential catch by fisheries. Indeed, total biomass, with no marine mammals in the ecosystem, generally remained surprisingly similar, or even decreased for some species. PMID:22970153

Vertical Distribution of Soil Denitrifying Communities in a Wet Sclerophyll Forest under Long-Term Repeated Burning.

PubMed

Liu, Xian; Chen, Chengrong; Wang, Weijin; Hughes, Jane M; Lewis, Tom; Hou, Enqing; Shen, Jupei

2015-11-01

Soil biogeochemical cycles are largely mediated by microorganisms, while fire significantly modifies biogeochemical cycles mainly via altering microbial community and substrate availability. Majority of studies on fire effects have focused on the surface soil; therefore, our understanding of the vertical distribution of microbial communities and the impacts of fire on nitrogen (N) dynamics in the soil profile is limited. Here, we examined the changes of soil denitrification capacity (DNC) and denitrifying communities with depth under different burning regimes, and their interaction with environmental gradients along the soil profile. Results showed that soil depth had a more pronounced impact than the burning treatment on the bacterial community size. The abundance of 16S rRNA and denitrification genes (narG, nirK, and nirS) declined exponentially with soil depth. Surprisingly, the nosZ-harboring denitrifiers were enriched in the deeper soil layers, which was likely to indicate that the nosZ-harboring denitrifiers could better adapt to the stress conditions (i.e., oxygen deficiency, nutrient limitation, etc.) than other denitrifiers. Soil nutrients, including dissolved organic carbon (DOC), total soluble N (TSN), ammonium (NH(4)(+)), and nitrate (NO(3)(-)), declined significantly with soil depth, which probably contributed to the vertical distribution of denitrifying communities. Soil DNC decreased significantly with soil depth, which was negligible in the depths below 20 cm. These findings have provided new insights into niche separation of the N-cycling functional guilds along the soil profile, under a varied fire disturbance regime.

Marine mammal impacts in exploited ecosystems: would large scale culling benefit fisheries?

PubMed

Morissette, Lyne; Christensen, Villy; Pauly, Daniel

2012-01-01

Competition between marine mammals and fisheries for marine resources-whether real or perceived-has become a major issue for several countries and in international fora. We examined trophic interactions between marine mammals and fisheries based on a resource overlap index, using seven Ecopath models including marine mammal groups. On a global scale, most food consumed by marine mammals consisted of prey types that were not the main target of fisheries. For each ecosystem, the primary production required (PPR) to sustain marine mammals was less than half the PPR to sustain fisheries catches. We also developed an index representing the mean trophic level of marine mammal's consumption (TL(Q)) and compared it with the mean trophic level of fisheries' catches (TL(C)). Our results showed that overall TL(Q) was lower than TL(C) (2.88 versus 3.42). As fisheries increasingly exploit lower-trophic level species, the competition with marine mammals may become more important. We used mixed trophic impact analysis to evaluate indirect trophic effects of marine mammals, and in some cases found beneficial effects on some prey. Finally, we assessed the change in the trophic structure of an ecosystem after a simulated extirpation of marine mammal populations. We found that this lead to alterations in the structure of the ecosystems, and that there was no clear and direct relationship between marine mammals' predation and the potential catch by fisheries. Indeed, total biomass, with no marine mammals in the ecosystem, generally remained surprisingly similar, or even decreased for some species.

Risk of 12-month mortality among hospital inpatients using the surprise question and SPICT criteria: a prospective study.

PubMed

Mudge, Alison M; Douglas, Carol; Sansome, Xanthe; Tresillian, Michael; Murray, Stephen; Finnigan, Simon; Blaber, Cheryl Ruth

2018-06-01

People with serious life-limiting disease benefit from advance care planning, but require active identification. This study applied the Gold Standards Framework Proactive Identification Guidance (GSF-PIG) to a general hospital population to describe high-risk patients and explore prognostic performance for 12-month mortality. Prospective cohort study conducted in a metropolitan teaching hospital in Australia. Hospital inpatients on a single day aged 18 years and older were eligible, excluding maternity and neonatal, mental health and day treatment patients. Data sources included medical record and structured questions for medical and nursing staff. High-risk was predefined as positive response to the surprise question (SQ) plus two or more SPICT indicators of general deterioration. Descriptive variables included demographics, frailty and functional measures, treating team, advance care planning documentation and hospital utilisation. Primary outcome for prognostic performance was 12-month mortality. We identified 540 eligible inpatients on the study day and 513 had complete data (mean age 60, 54% male, 30% living alone, 19% elective admissions). Of these, 191 (37%) were high-risk; they were older, frailer, more dependent and had been in hospital longer than low-risk participants. Within 12 months, 92 participants (18%) died (72/191(38%) high-risk versus 20/322(6%) low-risk, P<0.001), providing sensitivity 78%, specificity 72%, positive predictive value 38% and negative predictive value 94%. SQ alone provided higher sensitivity, adding advanced disease indicators improved specificity. The GSF-PIG approach identified a large minority of hospital inpatients who might benefit from advance care planning. Future studies are needed to investigate the feasibility, cost and impact of screening in hospitals. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Life histories and conservation of long-lived reptiles, an illustration with the American crocodile (Crocodylus acutus)

USGS Publications Warehouse

Briggs-Gonzalez, Venetia; Bonefant, Christophe; Basille, Mathieu; Cherkiss, Michael S.; Beauchamp, Jeff; Mazzotti, Frank J.

2017-01-01

Successful species conservation is dependent on adequate estimates of population dynamics, but age-specific demographics are generally lacking for many long-lived iteroparous species such as large reptiles. Accurate demographic information allows estimation of population growth rate, as well as projection of future population sizes and quantitative analyses of fitness trade-offs involved in the evolution of life-history strategies.Here, a long-term capture–recapture study was conducted from 1978 to 2014 on the American crocodile (Crocodylus acutus) in southern Florida. Over the study period, 7,427 hatchlings were marked and 380 individuals were recaptured for as many as 25 years. We estimated survival to be strongly age dependent with hatchlings having the lowest survival rates (16%) but increasing to nearly 90% at adulthood based on mark–recapture models. More than 5% of the female population were predicted to be reproductive by age 8 years; the age-specific proportion of reproductive females steadily increased until age 18 when more than 95% of females were predicted to be reproductive. Population growth rate, estimated from a Leslie–Lefkovitch stage-class model, showed a positive annual growth rate of 4% over the study period.Using a prospective sensitivity analysis, we revealed that the adult stage, as expected, was the most critical stage for population growth rate; however, the survival of younger crocodiles before they became reproductive also had a surprisingly high elasticity. We found that variation in age-specific fecundity has very limited impact on population growth rate in American crocodiles.We used a comparative approach to show that the original life-history strategy of American crocodiles is actually shared by other large, long-lived reptiles: while adult survival rates always have a large impact on population growth, this decreases with declining increasing growth rates, in favour of a higher elasticity of the juvenile stage.Crocodiles, as a long-lived and highly fecund species, deviate from the usual association of life histories of “slow” species. Current management practices are focused on nests and hatchling survival; however, protection efforts that extend to juvenile crocodiles would be most effective for conservation of the species, especially in an ever-developing landscape.

Satellite Re-entry Modeling and Uncertainty Quantification

NASA Astrophysics Data System (ADS)

Horsley, M.

2012-09-01

LEO trajectory modeling is a fundamental aerospace capability and has applications in many areas of aerospace, such as maneuver planning, sensor scheduling, re-entry prediction, collision avoidance, risk analysis, and formation flying. Somewhat surprisingly, modeling the trajectory of an object in low Earth orbit is still a challenging task. This is primarily due to the large uncertainty in the upper atmospheric density, about 15-20% (1-sigma) for most thermosphere models. Other contributions come from our inability to precisely model future solar and geomagnetic activities, the potentially unknown shape, material construction and attitude history of the satellite, and intermittent, noisy tracking data. Current methods to predict a satellite's re-entry trajectory typically involve making a single prediction, with the uncertainty dealt with in an ad-hoc manner, usually based on past experience. However, due to the extreme speed of a LEO satellite, even small uncertainties in the re-entry time translate into a very large uncertainty in the location of the re-entry event. Currently, most methods simply update the re-entry estimate on a regular basis. This results in a wide range of estimates that are literally spread over the entire globe. With no understanding of the underlying distribution of potential impact points, the sequence of impact points predicted by the current methodology are largely useless until just a few hours before re-entry. This paper will discuss the development of a set of the High Performance Computing (HPC)-based capabilities to support near real-time quantification of the uncertainty inherent in uncontrolled satellite re-entries. An appropriate management of the uncertainties is essential for a rigorous treatment of the re-entry/LEO trajectory problem. The development of HPC-based tools for re-entry analysis is important as it will allow a rigorous and robust approach to risk assessment by decision makers in an operational setting. Uncertainty quantification results from the recent uncontrolled re-entry of the Phobos-Grunt satellite will be presented and discussed. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Understanding and predicting ecological dynamics: Are major surprises inevitable

USGS Publications Warehouse

Doak, Daniel F.; Estes, James A.; Halpern, Benjamin S.; Jacob, Ute; Lindberg, D.R.; Lovvorn, James R.; Monson, Daniel H.; Tinker, M. Tim; Williams, Terrie M.; Wootton, J. Timothy; Carroll, Ian; Emmerson, Mark; Micheli, Fiorenza; Novak, Mark

2008-01-01

Ecological surprises, substantial and unanticipated changes in the abundance of one or more species that result from previously unsuspected processes, are a common outcome of both experiments and observations in community and population ecology. Here, we give examples of such surprises along with the results of a survey of well-established field ecologists, most of whom have encountered one or more surprises over the course of their careers. Truly surprising results are common enough to require their consideration in any reasonable effort to characterize nature and manage natural resources. We classify surprises as dynamic-, pattern-, or intervention-based, and we speculate on the common processes that cause ecological systems to so often surprise us. A long-standing and still growing concern in the ecological literature is how best to make predictions of future population and community dynamics. Although most work on this subject involves statistical aspects of data analysis and modeling, the frequency and nature of ecological surprises imply that uncertainty cannot be easily tamed through improved analytical procedures, and that prudent management of both exploited and conserved communities will require precautionary and adaptive management approaches.

Singly charged energetic helium emitted in solar flares

NASA Technical Reports Server (NTRS)

Hovestadt, D.; Hoefner, H.; Klecker, B.; Scholer, M.; Gloeckler, G.; Ipavich, F. M.; Fan, C. Y.; Fisk, L. A.; Ogallagher, J. J.

1981-01-01

First direct charge state measurements of 0.41-1.05 MeV per nucleon helium accelerated at the sun reveal surprisingly large abundances of singly ionized helium, with typical He(+)/He(++) ratios between 0.04 and 0.21. This unexpected overabundance of He(+) was observed in each of the three large solar-flare particle events which occurred between 1978 August and 1979 October. The data were obtained with the Max-Planck-Institut/University of Maryland Experiment on board the ISEE-3 spacecraft. The observations suggest either strong coronal temperature inhomogeneities including cool regions of approximately 100,000 K or injection of 'cold' chromospheric/photospheric material into the flare acceleration region.

Results of an Institutional LGBT Climate Survey at an Academic Medical Center.

PubMed

Chester, Sean D; Ehrenfeld, Jesse M; Eckstrand, Kristen L

2014-12-01

The purpose of this study was to characterize the climate and culture experienced by lesbian, gay, bisexual, and transgender (LGBT) employees and students at one large academic medical center. An anonymous, online institutional climate survey was used to assess the attitudes and experiences of LGBT employees and students. There were 42 LGBT and 14 non-LGBT survey participants. Results revealed that a surprisingly large percentage of LGBT individuals experienced pressure to remain "closeted" and were harassed despite medical center policies of non-discrimination. Continuing training, inclusive policies and practices, and the development of mechanisms to address LGBT-specific harassment are necessary for improving institutional climate.

Impact of monetary policy changes on the Chinese monetary and stock markets

NASA Astrophysics Data System (ADS)

Tang, Yong; Luo, Yong; Xiong, Jie; Zhao, Fei; Zhang, Yi-Cheng

2013-10-01

The impact of monetary policy changes on the monetary market and stock market in China is investigated in this study. The changes of two major monetary policies, the interest rate and required reserve ratio, are analyzed in a study period covering seven years on the interbank monetary market and Shanghai stock market. We find that the monetary market is related to the macro economy trend and we also find that the monetary change surprises both of lowering and raising bring significant impacts to the two markets and the two markets respond to the changes differently. The results suggest that the impact of fluctuations is much larger for raising policy changes than lowering changes in the monetary market on policy announcing and effective dates. This is consistent with the “sign effect”, i.e. bad news brings a greater impact than good news. By studying the event window of each policy change, we also find that the “sign effect” still exists before and after each change in the monetary market. A relatively larger fluctuation is observed before the event date, which indicates that the monetary market might have a certain ability to predict a potential monetary change, while it is kept secret by the central bank before official announcement. In the stock market, we investigate how the returns and spreads of the Shanghai stock market index respond to the monetary changes. Evidences suggest the stock market is influenced but in a different way than the monetary market. The climbing of returns after the event dates for the lowering policy agrees with the theory that lowering changes can provide a monetary supply to boost the market and drive the stock returns higher but with a delay of 2 to 3 trading days on average. While in the bear market, the lowering policy brings larger volatility to the market on average than the raising ones. These empirical findings are useful for policymakers to understand how monetary policy changes impact the monetary and stock markets especially in an emerging market like China where the economy is booming and the policy changes impact the markets as surprises by the central bank without a pre-decided schedule. This is totally different from previous studies on FED, which follows pre-decided schedules for monetary policy changes.

Contributing to Overall Life Satisfaction: Personality Traits Versus Life Satisfaction Variables Revisited—Is Replication Impossible?

PubMed Central

Lachmann, Bernd; Sariyska, Rayna; Kannen, Christopher; Błaszkiewicz, Konrad; Trendafilov, Boris; Andone, Ionut; Eibes, Mark; Markowetz, Alexander; Li, Mei; Kendrick, Keith M.

2017-01-01

Virtually everybody would agree that life satisfaction is of immense importance in everyday life. Thus, it is not surprising that a considerable amount of research using many different methodological approaches has investigated what the best predictors of life satisfaction are. In the present study, we have focused on several key potential influences on life satisfaction including bottom-up and top-down models, cross-cultural effects, and demographic variables. In four independent (large scale) surveys with sample sizes ranging from N = 488 to 40,297, we examined the associations between life satisfaction and various related variables. Our findings demonstrate that prediction of overall life satisfaction works best when including information about specific life satisfaction variables. From this perspective, satisfaction with leisure showed the highest impact on overall life satisfaction in our European samples. Personality was also robustly associated with life satisfaction, but only when life satisfaction variables were not included in the regression model. These findings could be replicated in all four independent samples, but it was also demonstrated that the relevance of life satisfaction variables changed under the influence of cross-cultural effects. PMID:29295529

School-located influenza vaccination and absenteeism among elementary school students in a Hispanic community.

PubMed

Keck, Patricia C; Ynalvez, Marcus Antonius; Gonzalez, Hector F; Castillo, Keila D

2013-08-01

Seasonal influenza is recognized as a significant health burden to children and is a cause of excess school absenteeism in children. In 2008, the Advisory Committee on Immunization Practices recommended annual influenza vaccination for all children 6 months to 18 years of age. School nurses influence participation in this recommendation by conducting school-located influenza vaccination (SLIV) programs at their campuses. Knowing the effect of SLIV programs on student absenteeism may motivate school nurses and district administrators to conduct such vaccination programs. This study examines the impact of an SLIV program on elementary school absenteeism in an inner city school district with a predominantly Hispanic population. Using Poisson regression models with robust standard errors, we analyzed data from 3,775 records obtained by stratified random sampling. Results of the study indicate that students vaccinated through an SLIV program have fewer absences than unvaccinated students. A surprising result of the study shows that students vaccinated through an SLIV program had fewer absences than students vaccinated elsewhere. These results are of particular importance to school nurses who work with large Hispanic populations. Our study illustrates one way that a school nurse can assess the effect of an SLIV program on absenteeism.

An optimal tuning strategy for tidal turbines

PubMed Central

2016-01-01

Tuning wind and tidal turbines is critical to maximizing their power output. Adopting a wind turbine tuning strategy of maximizing the output at any given time is shown to be an extremely poor strategy for large arrays of tidal turbines in channels. This ‘impatient-tuning strategy’ results in far lower power output, much higher structural loads and greater environmental impacts due to flow reduction than an existing ‘patient-tuning strategy’ which maximizes the power output averaged over the tidal cycle. This paper presents a ‘smart patient tuning strategy’, which can increase array output by up to 35% over the existing strategy. This smart strategy forgoes some power generation early in the half tidal cycle in order to allow stronger flows to develop later in the cycle. It extracts enough power from these stronger flows to produce more power from the cycle as a whole than the existing strategy. Surprisingly, the smart strategy can often extract more power without increasing maximum structural loads on the turbines, while also maintaining stronger flows along the channel. This paper also shows that, counterintuitively, for some tuning strategies imposing a cap on turbine power output to limit loads can increase a turbine’s average power output. PMID:27956870

Evaluating the core microbiota in complex communities: A systematic investigation.

PubMed

Astudillo-García, Carmen; Bell, James J; Webster, Nicole S; Glasl, Bettina; Jompa, Jamaluddin; Montoya, Jose M; Taylor, Michael W

2017-04-01

The study of complex microbial communities poses unique conceptual and analytical challenges, with microbial species potentially numbering in the thousands. With transient or allochthonous microorganisms often adding to this complexity, a 'core' microbiota approach, focusing only on the stable and permanent members of the community, is becoming increasingly popular. Given the various ways of defining a core microbiota, it is prudent to examine whether the definition of the core impacts upon the results obtained. Here we used complex marine sponge microbiotas and undertook a systematic evaluation of the degree to which different factors used to define the core influenced the conclusions. Significant differences in alpha- and beta-diversity were detected using some but not all core definitions. However, findings related to host specificity and environmental quality were largely insensitive to major changes in the core microbiota definition. Furthermore, none of the applied definitions altered our perception of the ecological networks summarising interactions among bacteria within the sponges. These results suggest that, while care should still be taken in interpretation, the core microbiota approach is surprisingly robust, at least for comparing microbiotas of closely related samples. © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.

Modeling of inter-neuronal coupling medium and its impact on neuronal synchronization

PubMed Central

Iqbal, Muhammad; Hong, Keum-Shik

2017-01-01

In this paper, modeling of the coupling medium between two neurons, the effects of the model parameters on the synchronization of those neurons, and compensation of coupling strength deficiency in synchronization are studied. Our study exploits the inter-neuronal coupling medium and investigates its intrinsic properties in order to get insight into neuronal-information transmittance and, there from, brain-information processing. A novel electrical model of the coupling medium that represents a well-known RLC circuit attributable to the coupling medium’s intrinsic resistive, inductive, and capacitive properties is derived. Surprisingly, the integration of such properties reveals the existence of a natural three-term control strategy, referred to in the literature as the proportional integral derivative (PID) controller, which can be responsible for synchronization between two neurons. Consequently, brain-information processing can rely on a large number of PID controllers based on the coupling medium properties responsible for the coherent behavior of neurons in a neural network. Herein, the effects of the coupling model (or natural PID controller) parameters are studied and, further, a supervisory mechanism is proposed that follows a learning and adaptation policy based on the particle swarm optimization algorithm for compensation of the coupling strength deficiency. PMID:28486505

An optimal tuning strategy for tidal turbines

NASA Astrophysics Data System (ADS)

Vennell, Ross

2016-11-01

Tuning wind and tidal turbines is critical to maximizing their power output. Adopting a wind turbine tuning strategy of maximizing the output at any given time is shown to be an extremely poor strategy for large arrays of tidal turbines in channels. This `impatient-tuning strategy' results in far lower power output, much higher structural loads and greater environmental impacts due to flow reduction than an existing `patient-tuning strategy' which maximizes the power output averaged over the tidal cycle. This paper presents a `smart patient tuning strategy', which can increase array output by up to 35% over the existing strategy. This smart strategy forgoes some power generation early in the half tidal cycle in order to allow stronger flows to develop later in the cycle. It extracts enough power from these stronger flows to produce more power from the cycle as a whole than the existing strategy. Surprisingly, the smart strategy can often extract more power without increasing maximum structural loads on the turbines, while also maintaining stronger flows along the channel. This paper also shows that, counterintuitively, for some tuning strategies imposing a cap on turbine power output to limit loads can increase a turbine's average power output.

Strong effects of ionizing radiation from Chernobyl on mutation rates

NASA Astrophysics Data System (ADS)

Møller, Anders Pape; Mousseau, Timothy A.

2015-02-01

In this paper we use a meta-analysis to examine the relationship between radiation and mutation rates in Chernobyl across 45 published studies, covering 30 species. Overall effect size of radiation on mutation rates estimated as Pearson's product-moment correlation coefficient was very large (E = 0.67; 95% confidence intervals (CI) 0.59 to 0.73), accounting for 44.3% of the total variance in an unstructured random-effects model. Fail-safe calculations reflecting the number of unpublished null results needed to eliminate this average effect size showed the extreme robustness of this finding (Rosenberg's method: 4135 at p = 0.05). Indirect tests did not provide any evidence of publication bias. The effect of radiation on mutations varied among taxa, with plants showing a larger effect than animals. Humans were shown to have intermediate sensitivity of mutations to radiation compared to other species. Effect size did not decrease over time, providing no evidence for an improvement in environmental conditions. The surprisingly high mean effect size suggests a strong impact of radioactive contamination on individual fitness in current and future generations, with potentially significant population-level consequences, even beyond the area contaminated with radioactive material.

Climate modelling of mass-extinction events: a review

NASA Astrophysics Data System (ADS)

Feulner, Georg

2009-07-01

Despite tremendous interest in the topic and decades of research, the origins of the major losses of biodiversity in the history of life on Earth remain elusive. A variety of possible causes for these mass-extinction events have been investigated, including impacts of asteroids or comets, large-scale volcanic eruptions, effects from changes in the distribution of continents caused by plate tectonics, and biological factors, to name but a few. Many of these suggested drivers involve or indeed require changes of Earth's climate, which then affect the biosphere of our planet, causing a global reduction in the diversity of biological species. It can be argued, therefore, that a detailed understanding of these climatic variations and their effects on ecosystems are prerequisites for a solution to the enigma of biological extinctions. Apart from investigations of the paleoclimate data of the time periods of mass extinctions, climate-modelling experiments should be able to shed some light on these dramatic events. Somewhat surprisingly, however, only a few comprehensive modelling studies of the climate changes associated with extinction events have been undertaken. These studies will be reviewed in this paper. Furthermore, the role of modelling in extinction research in general and suggestions for future research are discussed.

Strong effects of ionizing radiation from Chernobyl on mutation rates.

PubMed

Møller, Anders Pape; Mousseau, Timothy A

2015-02-10

In this paper we use a meta-analysis to examine the relationship between radiation and mutation rates in Chernobyl across 45 published studies, covering 30 species. Overall effect size of radiation on mutation rates estimated as Pearson's product-moment correlation coefficient was very large (E = 0.67; 95% confidence intervals (CI) 0.59 to 0.73), accounting for 44.3% of the total variance in an unstructured random-effects model. Fail-safe calculations reflecting the number of unpublished null results needed to eliminate this average effect size showed the extreme robustness of this finding (Rosenberg's method: 4135 at p = 0.05). Indirect tests did not provide any evidence of publication bias. The effect of radiation on mutations varied among taxa, with plants showing a larger effect than animals. Humans were shown to have intermediate sensitivity of mutations to radiation compared to other species. Effect size did not decrease over time, providing no evidence for an improvement in environmental conditions. The surprisingly high mean effect size suggests a strong impact of radioactive contamination on individual fitness in current and future generations, with potentially significant population-level consequences, even beyond the area contaminated with radioactive material.

Neurodevelopmental model of schizophrenia: update 2012

PubMed Central

Rapoport, JL; Giedd, JN; Gogtay, N

2012-01-01

The neurodevelopmental model of schizophrenia, which posits that the illness is the end state of abnormal neurodevelopmental processes that started years before the illness onset, is widely accepted, and has long been dominant for childhood-onset neuropsychiatric disorders. This selective review updates our 2005 review of recent studies that have impacted, or have the greatest potential to modify or extend, the neurodevelopmental model of schizophrenia. Longitudinal whole-population studies support a dimensional, rather than categorical, concept of psychosis. New studies suggest that placental pathology could be a key measure in future prenatal high-risk studies. Both common and rare genetic variants have proved surprisingly diagnostically nonspecific, and copy number variants (CNVs) associated with schizophrenia are often also associated with autism, epilepsy and intellectual deficiency. Large post-mortem gene expression studies and prospective developmental multi-modal brain imaging studies are providing critical data for future clinical and high-risk developmental brain studies. Whether there can be greater molecular specificity for phenotypic characterization is a subject of current intense study and debate, as is the possibility of neuronal phenotyping using human pluripotent-inducible stem cells. Biological nonspecificity, such as in timing or nature of early brain development, carries the possibility of new targets for broad preventive treatments. PMID:22488257

Function of GATA Factors in the Adult Mouse Liver

PubMed Central

Zheng, Rena; Rebolledo-Jaramillo, Boris; Zong, Yiwei; Wang, Liqing; Russo, Pierre; Hancock, Wayne; Stanger, Ben Z.; Hardison, Ross C.; Blobel, Gerd A.

2013-01-01

GATA transcription factors and their Friend of Gata (FOG) cofactors control the development of diverse tissues. GATA4 and GATA6 are essential for the expansion of the embryonic liver bud, but their expression patterns and functions in the adult liver are unclear. We characterized the expression of GATA and FOG factors in whole mouse liver and purified hepatocytes. GATA4, GATA6, and FOG1 are the most prominently expressed family members in whole liver and hepatocytes. GATA4 chromatin immunoprecipitation followed by high throughput sequencing (ChIP-seq) identified 4409 occupied sites, associated with genes enriched in ontologies related to liver function, including lipid and glucose metabolism. However, hepatocyte-specific excision of Gata4 had little impact on gross liver architecture and function, even under conditions of regenerative stress, and, despite the large number of GATA4 occupied genes, resulted in relatively few changes in gene expression. To address possible redundancy between GATA4 and GATA6, both factors were conditionally excised. Surprisingly, combined Gata4,6 loss did not exacerbate the phenotype resulting from Gata4 loss alone. This points to the presence of an unusually robust transcriptional network in adult hepatocytes that ensures the maintenance of liver function. PMID:24367609

An optimal tuning strategy for tidal turbines.

PubMed

Vennell, Ross

2016-11-01

Tuning wind and tidal turbines is critical to maximizing their power output. Adopting a wind turbine tuning strategy of maximizing the output at any given time is shown to be an extremely poor strategy for large arrays of tidal turbines in channels. This 'impatient-tuning strategy' results in far lower power output, much higher structural loads and greater environmental impacts due to flow reduction than an existing 'patient-tuning strategy' which maximizes the power output averaged over the tidal cycle. This paper presents a 'smart patient tuning strategy', which can increase array output by up to 35% over the existing strategy. This smart strategy forgoes some power generation early in the half tidal cycle in order to allow stronger flows to develop later in the cycle. It extracts enough power from these stronger flows to produce more power from the cycle as a whole than the existing strategy. Surprisingly, the smart strategy can often extract more power without increasing maximum structural loads on the turbines, while also maintaining stronger flows along the channel. This paper also shows that, counterintuitively, for some tuning strategies imposing a cap on turbine power output to limit loads can increase a turbine's average power output.

Equal-area criterion in power systems revisited

NASA Astrophysics Data System (ADS)

Sun, Yong; Ma, Jinpeng; Kurths, Jürgen; Zhan, Meng

2018-02-01

The classic equal-area criterion (EAC) is of key importance in power system analysis, and provides a powerful, pictorial and quantitative means of analysing transient stability (i.e. the system's ability to maintain stable operation when subjected to a large disturbance). Based on the traditional EAC, it is common sense in engineering that there is a critical cleaning time (CCT); namely, a power system is stable (unstable) if a fault is cleared before (after) this CCT. We regard this form of CCT as bipartite. In this paper, we revisit the EAC theory and, surprisingly, find different kinds of transient stability behaviour. Based on these analyses, we discover that the bipartite CCT is only one type among four major types, and, actually, the forms of CCT can be diversified. In particular, under some circumstances, a system may have no CCT or show a periodic CCT. Our theoretical analysis is verified by numerical simulations in a single-machine-infinite-bus system and also in multi-machine systems. Thus, our study provides a panoramic framework for diverse transient stability behaviour in power systems and also may have a significant impact on applications of multi-stability in various other systems, such as neuroscience, climatology or photonics.

Shocks near Jamming

NASA Astrophysics Data System (ADS)

Gómez, Leopoldo R.; Turner, Ari M.; van Hecke, Martin; Vitelli, Vincenzo

2012-02-01

Nonlinear sound is an extreme phenomenon typically observed in solids after violent explosions. But granular media are different. Right when they jam, these fragile and disordered solids exhibit a vanishing rigidity and sound speed, so that even tiny mechanical perturbations form supersonic shocks. Here, we perform simulations in which two-dimensional jammed granular packings are dynamically compressed and demonstrate that the elementary excitations are strongly nonlinear shocks, rather than ordinary phonons. We capture the full dependence of the shock speed on pressure and impact intensity by a surprisingly simple analytical model.

Role of Ultraviolet Disinfection in the Prevention of Surgical Site Infections.

PubMed

Simmons, Sarah; Dale, Charles; Holt, James; Velasquez, Katie; Stibich, Mark

2017-01-01

The role of the environment in surgical site infections is surprisingly understudied. UV disinfection holds promise for reducing the level of contamination in operating rooms and thereby lowering the risk of infection for patients. Issues such as the frequency, amount and locations for UV disinfection to have an impact on the risk of surgical site infection are recently emerging in the literature. As technologies and knowledge improve, UV disinfection will have a role to play in operating rooms in the future.

The Development and Status of Earth Science Education: A Comparison of Three Case Studies: Israel, England and Wales and the United States of America. Part I.

ERIC Educational Resources Information Center

Orion, Nir; King, Chris; Krockover, Gerald H.; Adams, Paul E.

1999-01-01

Explores the development and status of Earth Science Education in Israel and England and Wales. Finds that, despite separate traditions for education in the Earth Sciences, there are a surprisingly large number of commonalities between current trends in each of the countries in the study, and each has had difficulty determining what constitutes an…

Reliability of Standard Health Assessment Instruments in a Large, Population-Based Cohort Study

DTIC Science & Technology

2006-08-17

instruments include the PHQ (2, 8, 9), used to assess major depressive syndrome, panic syndrome, other anxiety syndrome, bulimia nervosa, alcohol abuse...2 weeks, 4 weeks, or recent months. This was particularly true of questions regarding anxiety and psychological condi- tions. Because a 6-month...2007: 525–532 530anxiety and psychological questions would not be surprising, since it has been reported that military members demon- strated

Qualitative properties of large buckled states of spherical shells

NASA Technical Reports Server (NTRS)

Shih, K. G.; Antman, S. S.

1985-01-01

A system of 6th-order quasi-linear Ordinary Differential Equations is analyzed to show the global existence of axisymmetrically buckled states. A surprising nodal property is obtained which shows that everywhere along a branch of solutions that bifurcates from a simple eigenvalue of the linearized equation, the number of simultaneously vanishing points of both shear resultant and circumferential bending moment resultant remains invariant, provided that a certain auxiliary condition is satisfied.

Mitigating Surprise Through Enhanced Operational Design: Civilian Conceptual Planning Models

DTIC Science & Technology

2007-01-01

political, historical, cultural , and economic contexts. If we are going to fight among the people, we must understand them.1 When evaluating US military...represents both the Christian and Yoruba minorities as well as the military, continues to compete against rival elites representing disparate elements...undeniably have to learn a new culture , the physical battlespace would not be alien since MS-13 maintains a large presence in areas that are home to

Insights and Challenges to Integrating Data from Diverse Ecological Networks

NASA Astrophysics Data System (ADS)

Peters, D. P. C.

2014-12-01

Many of the most dramatic and surprising effects of global change occur across large spatial extents, from regions to continents, that impact multiple ecosystem types across a range of interacting spatial and temporal scales. The ability of ecologists and inter-disciplinary scientists to understand and predict these dynamics depend, in large part, on existing site-based research infrastructures that developed in response to historic events. Integrating these diverse sources of data is critical to addressing these broad-scale questions. A conceptual approach is presented to synthesize and integrate diverse sources and types of data from different networks of research sites. This approach focuses on developing derived data products through spatial and temporal aggregation that allow datasets collected with different methods to be compared. The approach is illustrated through the integration, analysis, and comparison of hundreds of long-term datasets from 50 ecological sites in the US that represent ecosystem types commonly found globally. New insights were found by comparing multiple sites using common derived data. In addition to "bringing to light" many dark data in a standardized, open access, easy-to-use format, a suite of lessons were learned that can be applied to up and coming research networks in the US and internationally. These lessons will be described along with the challenges, including cyber-infrastructure, cultural, and behavioral constraints associated with the use of big and little data, that may keep ecologists and inter-disciplinary scientists from taking full advantage of the vast amounts of existing and yet-to-be exposed data.

Tetanus toxoid immunization to reduce mortality from neonatal tetanus.

PubMed

Blencowe, Hannah; Lawn, Joy; Vandelaer, Jos; Roper, Martha; Cousens, Simon

2010-04-01

Neonatal tetanus remains an important and preventable cause of neonatal mortality globally. Large reductions in neonatal tetanus deaths have been reported following major increases in the coverage of tetanus toxoid immunization, yet the level of evidence for the mortality effect of tetanus toxoid immunization is surprisingly weak with only two trials considered in a Cochrane review. To review the evidence for and estimate the effect on neonatal tetanus mortality of immunization with tetanus toxoid of pregnant women, or women of childbearing age. We conducted a systematic review of multiple databases. Standardized abstraction forms were used. Individual study quality and the overall quality of evidence were assessed using an adaptation of the GRADE approach. Meta-analyses were performed. Only one randomised controlled trial (RCT) and one well-controlled cohort study were identified, which met inclusion criteria for meta-analysis. Immunization of pregnant women or women of childbearing age with at least two doses of tetanus toxoid is estimated to reduce mortality from neonatal tetanus by 94% [95% confidence interval (CI) 80-98%]. Additionally, another RCT with a case definition based on day of death, 3 case-control studies and 1 before-and-after study gave consistent results. Based on the consistency of the mortality data, the very large effect size and that the data are all from low/middle-income countries, the overall quality of the evidence was judged to be moderate. This review uses a standard approach to provide a transparent estimate of the high impact of tetanus toxoid immunization on neonatal tetanus.

Seismic Shaking Removal of Craters 0.2-0.5 km in Diameter on Asteroid 433 Eros

NASA Technical Reports Server (NTRS)

Thomas, P. C.; Robinson, M. S.

2005-01-01

Impact cratering acts in a variety of ways to create a surprising range of scenery on small satellites and asteroids. The visible crater population is a self-modifying characteristic of these airless objects, and determining the various ways younger craters can add or subtract from the population is an important aspect of small body "geology." Asteroid 433 Eros, the most closely studied of any small body, has two aspects of its crater population that have attracted attention: a fall-off of crater densities below approx.100 m diameter relative to an expected equilibrium population [1] and regions of substantially lower large crater densities [2, 3, 4]. In this work we examine the global variation of the density of craters on Eros larger than 0.177 km, a size range above that involved in small crater depletion hypotheses [1, 5]. We counted all craters on Eros to a size range somewhat below 0.177 km diameter (and different from data used in [3]). The primary metric for this study is the number of craters between 0.177 and 1.0 km within a set radius of each grid point on the 2deg x 2deg shape model of Eros. This number can be expressed as an R-value [6], provided that it is remembered that the large bin size makes individual R values slightly different from those obtained in the usual root-2 bins.

Impact of interannual variability (1979-1986) of transport and temperature on ozone as computed using a two-dimensional photochemical model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jackman, C.H.; Douglass, A.R., Chandra, S.; Stolarski, R.S.

1991-03-20

Eight years of NMC (National Meteorological Center) temperature and SBUV (solar backscattered ultraviolet) ozone data were used to calculate the monthly mean heating rates and residual circulation for use in a two-dimensional photochemical model in order to examine the interannual variability of modeled ozone. Fairly good correlations were found in the interannual behavior of modeled and measured SBUV ozone in the upper stratosphere at middle to low latitudes, where temperature dependent photochemistry is thought to dominate ozone behavior. The calculated total ozone is found to be more sensitive to the interannual residual circulation changes than to the interannual temperature changes.more » The magnitude of the modeled ozone variability is similar to the observed variability, but the observed and modeled year to year deviations are mostly uncorrelated. The large component of the observed total ozone variability at low latitudes due to the quasi-biennial oscillation (QBO) is not seen in the modeled total ozone, as only a small QBO signal is present in the heating rates, temperatures, and monthly mean residual circulation. Large interanual changes in tropospheric dynamics are believed to influence the interannual variability in the total ozone, especially at middle and high latitudes. Since these tropospheric changes and most of the QBO forcing are not included in the model formulation, it is not surprising that the interannual variability in total ozione is not well represented in the model computations.« less

Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate.

PubMed

Gees, Maarten; Alpizar, Yeranddy A; Boonen, Brett; Sanchez, Alicia; Everaerts, Wouter; Segal, Andrei; Xue, Fenqin; Janssens, Annelies; Owsianik, Grzegorz; Nilius, Bernd; Voets, Thomas; Talavera, Karel

2013-09-01

Allyl isothiocyanate (AITC; aka, mustard oil) is a powerful irritant produced by Brassica plants as a defensive trait against herbivores and confers pungency to mustard and wasabi. AITC is widely used experimentally as an inducer of acute pain and neurogenic inflammation, which are largely mediated by the activation of nociceptive cation channels transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 (TRPV1). Although it is generally accepted that electrophilic agents activate these channels through covalent modification of cytosolic cysteine residues, the mechanism underlying TRPV1 activation by AITC remains unknown. Here we show that, surprisingly, AITC-induced activation of TRPV1 does not require interaction with cysteine residues, but is largely dependent on S513, a residue that is involved in capsaicin binding. Furthermore, AITC acts in a membrane-delimited manner and induces a shift of the voltage dependence of activation toward negative voltages, which is reminiscent of capsaicin effects. These data indicate that AITC acts through reversible interactions with the capsaicin binding site. In addition, we show that TRPV1 is a locus for cross-sensitization between AITC and acidosis in nociceptive neurons. Furthermore, we show that residue F660, which is known to determine the stimulation by low pH in human TRPV1, is also essential for the cross-sensitization of the effects of AITC and low pH. Taken together, these findings demonstrate that not all reactive electrophiles stimulate TRPV1 via cysteine modification and help understanding the molecular bases underlying the surprisingly large role of this channel as mediator of the algesic properties of AITC.

A New Sputnik Surprise?

NASA Technical Reports Server (NTRS)

Lowman, Paul D., Jr.; Smith, David E. (Technical Monitor)

2001-01-01

This paper suggests that a new "Sputnik surprise" in the form of a joint Chinese-Russian lunar base program may emerge in this decade. The Moon as a whole has been shown to be territory of strategic value, with discovery of large amounts of hydrogen (probably water ice) at the lunar poles and helium 3 everywhere in the soil, in addition to the Moon's scientific value as an object of study and as a platform for astronomy. There is thus good reason for a return to the Moon, robotically or manned. Relations between China and Russia have thawed since the mid-1990s, and the two countries have a formal space cooperation pact. It is argued here that a manned lunar program would be feasible within 5 years, using modern technology and proven spacecraft and launch vehicles. The combination of Russian lunar hardware with Chinese space technology would permit the two countries together to take the lead in solar system exploration in the 21st century.

Nucleosynthesis: Stellar and Solar Abundances and Atomic Data

NASA Technical Reports Server (NTRS)

Cowan, John J.; Lawler, James E.; Sneden, Christopher; DenHartog, E. A.; Collier, Jason; Dodge, Homer L.

2006-01-01

Abundance observations indicate the presence of often surprisingly large amounts of neutron capture (i.e., s- and r-process) elements in old Galactic halo and globular cluster stars. These observations provide insight into the nature of the earliest generations of stars in the Galaxy the progenitors of the halo stars responsible for neutron-capture synthesis. Comparisons of abundance trends can be used to understand the chemical evolution of the Galaxy and the nature of heavy element nucleosynthesis. In addition age determinations, based upon long-lived radioactive nuclei abundances, can now be obtained. These stellar abundance determinations depend critically upon atomic data. Improved laboratory transition probabilities have been recently obtained for a number of elements. These new gf values have been used to greatly refine the abundances of neutron-capture elemental abundances in the solar photosphere and in very metal-poor Galactic halo stars. The newly determined stellar abundances are surprisingly consistent with a (relative) Solar System r-process pattern, and are also consistent with abundance predictions expected from such neutron-capture nucleosynthesis.

Estimation abilities of large numerosities in Kindergartners

PubMed Central

Mejias, Sandrine; Schiltz, Christine

2013-01-01

The approximate number system (ANS) is thought to be a building block for the elaboration of formal mathematics. However, little is known about how this core system develops and if it can be influenced by external factors at a young age (before the child enters formal numeracy education). The purpose of this study was to examine numerical magnitude representations of 5–6 year old children at 2 different moments of Kindergarten considering children's early number competence as well as schools' socio-economic index (SEI). This study investigated estimation abilities of large numerosities using symbolic and non-symbolic output formats (8–64). In addition, we assessed symbolic and non-symbolic early number competence (1–12) at the end of the 2nd (N = 42) and the 3rd (N = 32) Kindergarten grade. By letting children freely produce estimates we observed surprising estimation abilities at a very young age (from 5 year on) extending far beyond children's symbolic explicit knowledge. Moreover, the time of testing has an impact on the ANS accuracy since 3rd Kindergarteners were more precise in both estimation tasks. Additionally, children who presented better exact symbolic knowledge were also those with the most refined ANS. However, this was true only for 3rd Kindergarteners who were a few months from receiving math instructions. In a similar vein, higher SEI positively impacted only the oldest children's estimation abilities whereas it played a role for exact early number competences already in 2nd and 3rd graders. Our results support the view that approximate numerical representations are linked to exact number competence in young children before the start of formal math education and might thus serve as building blocks for mathematical knowledge. Since this core number system was also sensitive to external components such as the SEI this implies that it can most probably be targeted and refined through specific educational strategies from preschool on. PMID:24009591

Ocean acidification impacts bacteria-phytoplankton coupling at low-nutrient conditions

NASA Astrophysics Data System (ADS)

Hornick, Thomas; Bach, Lennart T.; Crawfurd, Katharine J.; Spilling, Kristian; Achterberg, Eric P.; Woodhouse, Jason N.; Schulz, Kai G.; Brussaard, Corina P. D.; Riebesell, Ulf; Grossart, Hans-Peter

2017-01-01

The oceans absorb about a quarter of the annually produced anthropogenic atmospheric carbon dioxide (CO2), resulting in a decrease in surface water pH, a process termed ocean acidification (OA). Surprisingly little is known about how OA affects the physiology of heterotrophic bacteria or the coupling of heterotrophic bacteria to phytoplankton when nutrients are limited. Previous experiments were, for the most part, undertaken during productive phases or following nutrient additions designed to stimulate algal blooms. Therefore, we performed an in situ large-volume mesocosm ( ˜ 55 m3) experiment in the Baltic Sea by simulating different fugacities of CO2 (fCO2) extending from present to future conditions. The study was conducted in July-August after the nominal spring bloom, in order to maintain low-nutrient conditions throughout the experiment. This resulted in phytoplankton communities dominated by small-sized functional groups (picophytoplankton). There was no consistent fCO2-induced effect on bacterial protein production (BPP), cell-specific BPP (csBPP) or biovolumes (BVs) of either free-living (FL) or particle-associated (PA) heterotrophic bacteria, when considered as individual components (univariate analyses). Permutational Multivariate Analysis of Variance (PERMANOVA) revealed a significant effect of the fCO2 treatment on entire assemblages of dissolved and particulate nutrients, metabolic parameters and the bacteria-phytoplankton community. However, distance-based linear modelling only identified fCO2 as a factor explaining the variability observed amongst the microbial community composition, but not for explaining variability within the metabolic parameters. This suggests that fCO2 impacts on microbial metabolic parameters occurred indirectly through varying physicochemical parameters and microbial species composition. Cluster analyses examining the co-occurrence of different functional groups of bacteria and phytoplankton further revealed a separation of the four fCO2-treated mesocosms from both control mesocosms, indicating that complex trophic interactions might be altered in a future acidified ocean. Possible consequences for nutrient cycling and carbon export are still largely unknown, in particular in a nutrient-limited ocean.

Land use history, floodplain development, and soil erosion in the vicinity of a millstone production center since the Iron Age in the Segbachtal near Mayen (eastern Eifel, Germany)

NASA Astrophysics Data System (ADS)

Dotterweich, Markus; Wenzel, Stefan; Schreg, Rainer; Fülling, Alexander; Engel, Max

2015-04-01

In Roman times, the stone and pottery production near Mayen in western Germany reached a very high intensity which would have satisfied the needs of a much wider area. The rate and volume of production was unprecedented and never reached the same level thereafter. The Segbach valley study site with an area of only a few square kilometres offers a very special geoarchaeological archive. The Roman land use structures were completely preserved under a 2 meter thick layer of sediment and are now partially exposed in a gully due to erosion. Pedological, sedimentological and geophysical studies at the colluvium and floodplain sediments as well as relict field structures showed that in the last 2500 years there has been a considerable human impact on both water and sediment budgets. This also had various implications on the further development of water courses, soils and relief. Evidence for the development of flood plain sediments can be traced as far back as the late La Tène period, the Roman Iron Age, and since the Middle Ages. On one particular south-facing slope we found evidence of recultivation measures on a former quarry tailing heap dating from the Middle Ages. This and other human construction activities and land uses lead to a significant change in erosion and sedimentation patterns. It is surprising that sedimentation in flood plains was largely absent during the Roman Iron Age despite intensive land use. Evidence shows that flash flood events with intensive accumulation of soil matter in flood plains only occurred during the High Middle Ages. Sediments from the late Middle ages and the Modern Times are largely missing. The research undertaken in Segbach valley not only offers new insights into specific local historical land uses and land use changes but also fundamental knowledge about the principles and impacts of long-term human-environment interactions.

The Living Experience of Feeling Surprised.

PubMed

Bunkers, Sandra Schmidt

2017-01-01

The purpose of this article is to report the finding of a Parse research method study on the universal living experience of feeling surprised. In dialogical engagement with the researcher, eight participants described the experience. The structure of the living experience of feeling surprised was found to be: Feeling surprised is stunning amazement arising with shifting fortunes, as delight amid despair surfaces with diverse involvements.

A Contrast-Based Computational Model of Surprise and Its Applications.

PubMed

Macedo, Luis; Cardoso, Amílcar

2017-11-19

We review our work on a contrast-based computational model of surprise and its applications. The review is contextualized within related research from psychology, philosophy, and particularly artificial intelligence. Influenced by psychological theories of surprise, the model assumes that surprise-eliciting events initiate a series of cognitive processes that begin with the appraisal of the event as unexpected, continue with the interruption of ongoing activity and the focusing of attention on the unexpected event, and culminate in the analysis and evaluation of the event and the revision of beliefs. It is assumed that the intensity of surprise elicited by an event is a nonlinear function of the difference or contrast between the subjective probability of the event and that of the most probable alternative event (which is usually the expected event); and that the agent's behavior is partly controlled by actual and anticipated surprise. We describe applications of artificial agents that incorporate the proposed surprise model in three domains: the exploration of unknown environments, creativity, and intelligent transportation systems. These applications demonstrate the importance of surprise for decision making, active learning, creative reasoning, and selective attention. Copyright © 2017 Cognitive Science Society, Inc.

Cost and impact of a quality improvement programme in mental health services.

PubMed

Beecham, Jennifer; Ramsay, Angus; Gordon, Kate; Maltby, Sophie; Walshe, Kieran; Shaw, Ian; Worrall, Adrian; King, Sarah

2010-04-01

To estimate the cost and impact of a centrally-driven quality improvement initiative in four UK mental health communities. Total costs in year 1 were identified using documentation, a staff survey, semi-structured interviews and discussion groups. Few outcome data were collected within the programme so thematic analysis was used to identify the programme's impact within its five broad underlying principles. The survey had a 40% response. Total costs ranged between pound164,000 and pound458,000 per site, plus staff time spent on workstreams. There was a very hazy view of the resources absorbed and poor recording of expenditure and activity. The initiative generated little demonstrable improvements in service quality but some participants reported changes in attitudes. Given the difficult contexts, short time-scales and capacity constraints, the programme's lack of impact is not surprising. It may, however, represent a worthwhile investment in cultural change which might facilitate improvements in how services are delivered.

An Ongoing Program for Monitoring the Moon for Meteoroid Impacts (Abstract)

NASA Astrophysics Data System (ADS)

Cudnik, B.; Saganti, S.; Ali, F.; Ali, S.; Beharie, T.; Anugwom, B.

2017-12-01

(Abstract only) Lunar meteor impacts are surprisingly frequent phenomena, with well over one hundred observable events occurring each year. Of these a little over half arise from members of annual meteor showers (e.g. Perseids, Leonids, etc.), with the rest being sporadic in origin. Five years ago, I (BC) introduced to the SAS Symposium the idea of observing lunar meteoroid impact phenomena and applying these observations to a space mission (LADEE-Lunar Atmosphere and Dust Environment Explorer) that launched the following year. Now, five years later I revisit and reintroduce the activities of the Association of Lunar and Planetary Observers-Lunar Meteoritic Impact Search (ALPO-LMIS) section and share some of the latest observations that have been received. For over 17 years now, ALPO has hosted the LMIS section, for which I have served as coordinator since its inception. In this paper, I will revisit the main ideas of the earlier paper, share some recent observations of lunar meteors, and provide new initiatives and projects interested persons can participate in.

Why the Lack of Academic Literature on Export Controls?

NASA Technical Reports Server (NTRS)

Kremic, Tibor

2001-01-01

Export controls is currently a relevant and dynamic topic. Given the growth of global operations and the high-tech nature of many products, an increase in awareness and understanding of the impacts of export controls are necessary. A structured approach to export controls has been in existence since 1949. Despite over 50 years of history, surprisingly little academic research and literature exists on the topic. This paper explores the current export control environment and explores possible reasons for the limited academic interest. Five possible reasons are discussed: (1) dynamic nature of the topic; (2) difficulty in ensuring accurate data; (3) Complexity of the problem; (4) relatively small economic impact; and (5) sensitive information. A research approach is recommended that considers these potential obstacles.

The pit and the pendulum: the impact on teen smokers of including a designated smoking area in school tobacco control policy.

PubMed

Baillie, L E; Lovato, C Y; Taylor, E; Rutherford, M B; Smith, M

2008-12-01

Thirty per cent of school districts in British Columbia do not ban smoking outright on school grounds, and in several instances, smoking is permitted in smoking pits, regardless of school district policy. While there is evidence to suggest that enforcing a tobacco-free environment for students does reduce adolescent smoking rates, the concomitant safety and discipline problems it creates for school staff and administration are demanding and complex, and may override concerns regarding student smoking. This study uses a qualitative approach to explore the meanings that students place on tobacco control policy and the impact that these meanings have on their own smoking behaviours. We found that students were surprised and concerned that smoking was permitted on school property and that it negatively impacted their own tobacco prevention/control/cessation attempts.

Dyslexia and learning disabilities in Canada and the UK: the impact of its disability employment laws.

PubMed

Gerber, Paul J; Batalo, Cecilia G; Achola, Edwin O

2012-08-01

The impact of employment laws pertaining to individuals with learning disabilities in Canada and dyslexia in the UK were investigated via the extant research literature. Currently, there is very little research in this area despite Canada and the UK having laws in effect for decades. Surprisingly, their laws have been revamped despite an absence of data that measures impact and effectiveness. This finding is not unlike the Americans with Disabilities Act, reauthorized as the Americans with Disabilities Act Amendments in 2008, without substantive research to guide legal policies and practices going forward. Investigation in this area is needed to seek the positive and negative effects of legislation on those with learning disabilities in Canada and dyslexia in the UK, a high incidence population that finds most employment opportunities in competitive employment. Copyright © 2012 John Wiley & Sons, Ltd.

Oblique impact of dense granular sheets

NASA Astrophysics Data System (ADS)

Ellowitz, Jake; Guttenberg, Nicholas; Jaeger, Heinrich M.; Nagel, Sidney R.; Zhang, Wendy W.

2013-11-01

Motivated by experiments showing impacts of granular jets with non-circular cross sections produce thin ejecta sheets with anisotropic shapes, we study what happens when two sheets containing densely packed, rigid grains traveling at the same speed collide asymmetrically. Discrete particle simulations and a continuum frictional fluid model yield the same steady-state solution of two exit streams emerging from incident streams. When the incident angle Δθ is less than Δθc =120° +/-10° , the exit streams' angles differ from that measured in water sheet experiments. Below Δθc , the exit angles from granular and water sheet impacts agree. This correspondence is surprising because 2D Euler jet impact, the idealization relevant for both situations, is ill posed: a generic Δθ value permits a continuous family of solutions. Our finding that granular and water sheet impacts evolve into the same member of the solution family suggests previous proposals that perturbations such as viscous drag, surface tension or air entrapment select the actual outcome are not correct. Currently at Department of Physics, University of Oregon, Eugene, OR 97403.

"Too stubborn to ever be governed by enforced insanity": Some therapeutic jurisprudence dilemmas in the representation of criminal defendants in incompetency and insanity cases.

PubMed

Perlin, Michael L

2010-01-01

Little attention has been paid to the importance of the relationship between therapeutic jurisprudence (TJ) and the role of criminal defense lawyers in insanity and incompetency-to-stand-trial (IST) cases. That inattention is especially noteworthy in light of the dismal track record of counsel providing services to defendants who are part of this cohort of incompetency-status-raisers and insanity-defense-pleaders. On one hand, this lack of attention is a surprise as TJ scholars have, in recent years, turned their attention to virtually every other aspect of the legal system. On the other hand, it is not a surprise, given the omnipresence of sanism, an irrational prejudice of the same quality and character of other irrational prejudices that cause (and are reflected in) prevailing social attitudes of racism, sexism, homophobia, and ethnic bigotry, that infects both our jurisprudence and our lawyering practices. Sanism is largely invisible and largely socially acceptable, and is based predominantly upon stereotype, myth, superstition, and deindividualization. It is sustained and perpetuated by our use of alleged "ordinary common sense" (OCS) and heuristic reasoning in an unconscious response to events both in everyday life and in the legal process. This paper examines the literature that seeks to apply TJ principles to the criminal law process in general, drawing mostly on the work of Professor David Wexler. It considers why the lack of attention that I have referred to already is surprising (given TJ's mandate and the fact that many TJ issues are inevitably raised in any insanity or IST case). The paper then considers why this lack of attention is not surprising, given the omnipresence of sanism. It will consider some of the actual counseling issues that might arise in these contexts, and offer some suggestions to lawyers representing clients in cases in which mental status issues may be raised. The paper concludes that we must rigorously apply therapeutic jurisprudence principles to these issues, so as to strip away sanist behavior, pretextual reasoning and teleological decision making from the criminal competency and responsibility processes, so as to enable us to confront the pretextual use of social science data in an open and meaningful way. This gambit would also allow us to address-in a more successful way than has ever yet been done-the problems raised by the omnipresence of ineffective counsel in cases involving defendants with mental disabilities. Copyright © 2010 Elsevier Ltd. All rights reserved.

A Statistical Analysis of the Relationship between Harmonic Surprise and Preference in Popular Music.

PubMed

Miles, Scott A; Rosen, David S; Grzywacz, Norberto M

2017-01-01

Studies have shown that some musical pieces may preferentially activate reward centers in the brain. Less is known, however, about the structural aspects of music that are associated with this activation. Based on the music cognition literature, we propose two hypotheses for why some musical pieces are preferred over others. The first, the Absolute-Surprise Hypothesis, states that unexpected events in music directly lead to pleasure. The second, the Contrastive-Surprise Hypothesis, proposes that the juxtaposition of unexpected events and subsequent expected events leads to an overall rewarding response. We tested these hypotheses within the framework of information theory, using the measure of "surprise." This information-theoretic variable mathematically describes how improbable an event is given a known distribution. We performed a statistical investigation of surprise in the harmonic structure of songs within a representative corpus of Western popular music, namely, the McGill Billboard Project corpus. We found that chords of songs in the top quartile of the Billboard chart showed greater average surprise than those in the bottom quartile. We also found that the different sections within top-quartile songs varied more in their average surprise than the sections within bottom-quartile songs. The results of this study are consistent with both the Absolute- and Contrastive-Surprise Hypotheses. Although these hypotheses seem contradictory to one another, we cannot yet discard the possibility that both absolute and contrastive types of surprise play roles in the enjoyment of popular music. We call this possibility the Hybrid-Surprise Hypothesis. The results of this statistical investigation have implications for both music cognition and the human neural mechanisms of esthetic judgments.

A Statistical Analysis of the Relationship between Harmonic Surprise and Preference in Popular Music

PubMed Central

Miles, Scott A.; Rosen, David S.; Grzywacz, Norberto M.

2017-01-01

Studies have shown that some musical pieces may preferentially activate reward centers in the brain. Less is known, however, about the structural aspects of music that are associated with this activation. Based on the music cognition literature, we propose two hypotheses for why some musical pieces are preferred over others. The first, the Absolute-Surprise Hypothesis, states that unexpected events in music directly lead to pleasure. The second, the Contrastive-Surprise Hypothesis, proposes that the juxtaposition of unexpected events and subsequent expected events leads to an overall rewarding response. We tested these hypotheses within the framework of information theory, using the measure of “surprise.” This information-theoretic variable mathematically describes how improbable an event is given a known distribution. We performed a statistical investigation of surprise in the harmonic structure of songs within a representative corpus of Western popular music, namely, the McGill Billboard Project corpus. We found that chords of songs in the top quartile of the Billboard chart showed greater average surprise than those in the bottom quartile. We also found that the different sections within top-quartile songs varied more in their average surprise than the sections within bottom-quartile songs. The results of this study are consistent with both the Absolute- and Contrastive-Surprise Hypotheses. Although these hypotheses seem contradictory to one another, we cannot yet discard the possibility that both absolute and contrastive types of surprise play roles in the enjoyment of popular music. We call this possibility the Hybrid-Surprise Hypothesis. The results of this statistical investigation have implications for both music cognition and the human neural mechanisms of esthetic judgments. PMID:28572763

An Investigation in Atmospheric Dynamics and Its Effects on Optical Emissions

DTIC Science & Technology

1991-08-01

waves are as follows: (1) Power spectrum analyses of simultaneous phot01- tric observations 11... of mesospheric and lower thermospheric optical...MAPSTAR Campaign) se-ms to show a surprisingly large number of power peaks with short periods. This would seem to suggest that the higher Fourier...directly aid hame aixrlcw height changes can be est-maed. •idle sawb of ouw results are known qualitatively to G. W. specalists, to ouw ) kowledge there has

Korean Affairs Report

DTIC Science & Technology

1986-09-09

U.S. Volvo 13. Other 14. Subtotal 15. Toyota 16. Nissan 17. Honda 18. Mazda 19. Mitsubishi 20. Fujitsu 21. Isuzu 22. Suzuki 23. Japanese...cars & Percent Unit=1,000 3. Company 4. U.S.-Made Cars 5. Imported Cars 6. GM 7. Ford 8. Chrysler 9. AMC 10. U.S. Nissan 11. U.S. Honda 12...24 percent. This is a surprisingly large increase compared with the current 1.7 percent. Until 1983, the prospect of Korean automobile exports was

Large magnetoresistance in non-magnetic silver chalcogenides and new class of magnetoresistive compounds

DOEpatents

Saboungi, Marie-Louis; Price, David C. L.; Rosenbaum, Thomas F.; Xu, Rong; Husmann, Anke

2001-01-01

The heavily-doped silver chalcogenides, Ag.sub.2+.delta. Se and Ag.sub.2+.delta. Te, show magnetoresistance effects on a scale comparable to the "colossal" magnetoresistance (CMR) compounds. Hall coefficient, magnetoconductivity, and hydrostatic pressure experiments establish that elements of narrow-gap semiconductor physics apply, but both the size of the effects at room temperature and the linear field dependence down to fields of a few Oersteds are surprising new features.

Genetic and pharmacological reactivation of the mammalian inactive X chromosome

PubMed Central

Bhatnagar, Sanchita; Zhu, Xiaochun; Ou, Jianhong; Lin, Ling; Chamberlain, Lynn; Zhu, Lihua J.; Wajapeyee, Narendra; Green, Michael R.

2014-01-01

X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal expression of X-linked genes in both sexes. XCI is initiated in cis by the noncoding Xist RNA, which coats the inactive X chromosome (Xi) from which it is produced. However, trans-acting factors that mediate XCI remain largely unknown. Here, we perform a large-scale RNA interference screen to identify trans-acting XCI factors (XCIFs) that comprise regulators of cell signaling and transcription, including the DNA methyltransferase, DNMT1. The expression pattern of the XCIFs explains the selective onset of XCI following differentiation. The XCIFs function, at least in part, by promoting expression and/or localization of Xist to the Xi. Surprisingly, we find that DNMT1, which is generally a transcriptional repressor, is an activator of Xist transcription. Small-molecule inhibitors of two of the XCIFs can reversibly reactivate the Xi, which has implications for treatment of Rett syndrome and other dominant X-linked diseases. A homozygous mouse knockout of one of the XCIFs, stanniocalcin 1 (STC1), has an expected XCI defect but surprisingly is phenotypically normal. Remarkably, X-linked genes are not overexpressed in female Stc1−/− mice, revealing the existence of a mechanism(s) that can compensate for a persistent XCI deficiency to regulate X-linked gene expression. PMID:25136103

Fractal morphology, imaging and mass spectrometry of single aerosol particles in flight.

PubMed

Loh, N D; Hampton, C Y; Martin, A V; Starodub, D; Sierra, R G; Barty, A; Aquila, A; Schulz, J; Lomb, L; Steinbrener, J; Shoeman, R L; Kassemeyer, S; Bostedt, C; Bozek, J; Epp, S W; Erk, B; Hartmann, R; Rolles, D; Rudenko, A; Rudek, B; Foucar, L; Kimmel, N; Weidenspointner, G; Hauser, G; Holl, P; Pedersoli, E; Liang, M; Hunter, M S; Hunter, M M; Gumprecht, L; Coppola, N; Wunderer, C; Graafsma, H; Maia, F R N C; Ekeberg, T; Hantke, M; Fleckenstein, H; Hirsemann, H; Nass, K; White, T A; Tobias, H J; Farquar, G R; Benner, W H; Hau-Riege, S P; Reich, C; Hartmann, A; Soltau, H; Marchesini, S; Bajt, S; Barthelmess, M; Bucksbaum, P; Hodgson, K O; Strüder, L; Ullrich, J; Frank, M; Schlichting, I; Chapman, H N; Bogan, M J

2012-06-27

The morphology of micrometre-size particulate matter is of critical importance in fields ranging from toxicology to climate science, yet these properties are surprisingly difficult to measure in the particles' native environment. Electron microscopy requires collection of particles on a substrate; visible light scattering provides insufficient resolution; and X-ray synchrotron studies have been limited to ensembles of particles. Here we demonstrate an in situ method for imaging individual sub-micrometre particles to nanometre resolution in their native environment, using intense, coherent X-ray pulses from the Linac Coherent Light Source free-electron laser. We introduced individual aerosol particles into the pulsed X-ray beam, which is sufficiently intense that diffraction from individual particles can be measured for morphological analysis. At the same time, ion fragments ejected from the beam were analysed using mass spectrometry, to determine the composition of single aerosol particles. Our results show the extent of internal dilation symmetry of individual soot particles subject to non-equilibrium aggregation, and the surprisingly large variability in their fractal dimensions. More broadly, our methods can be extended to resolve both static and dynamic morphology of general ensembles of disordered particles. Such general morphology has implications in topics such as solvent accessibilities in proteins, vibrational energy transfer by the hydrodynamic interaction of amino acids, and large-scale production of nanoscale structures by flame synthesis.

Flashbulb memories of Paris attacks

PubMed Central

El Haj, Mohamad; Gandolphe, Marie-Charlotte; Wawrziczny, Emilie; Antoine, Pascal

2016-01-01

Abstract Rationale: Flashbulb memories are detailed and vivid memories of attributes of the reception context of surprising and emotionally arousing public events. Patient concerns and diagnosis: This paper offers a fine-grained view of flashbulb memories in a patient with mild Alzheimer's disease (AD). Interventions: The patient underwent a directed interview about the 13 November 2015 attacks in Paris. Outcomes: Unlike her memory about the date and month of the attacks, the patient provided accurate information about the year, time and places they occurred. The patient also provided accurate information about how she first became aware of the attacks, where she was, with whom, what she was doing, and what time it was when she learned about them. As for the affective characteristics of these memories, she tended to have high ratings of vividness and rehearsal. Negative emotional states and great surprise and novelty were also reported. Lessons: By assessing the impact of flashbulb memories in this patient with AD, this paper offers a unique view into how such memories may trigger a considerable recall of context as well much subjective reliving. PMID:27861395

Flashbulb memories of Paris attacks: Recall of these events and subjective reliving of these memories in a case with Alzheimer disease.

PubMed

El Haj, Mohamad; Gandolphe, Marie-Charlotte; Wawrziczny, Emilie; Antoine, Pascal

2016-11-01

Flashbulb memories are detailed and vivid memories of attributes of the reception context of surprising and emotionally arousing public events. This paper offers a fine-grained view of flashbulb memories in a patient with mild Alzheimer's disease (AD). The patient underwent a directed interview about the 13 November 2015 attacks in Paris. Unlike her memory about the date and month of the attacks, the patient provided accurate information about the year, time and places they occurred. The patient also provided accurate information about how she first became aware of the attacks, where she was, with whom, what she was doing, and what time it was when she learned about them. As for the affective characteristics of these memories, she tended to have high ratings of vividness and rehearsal. Negative emotional states and great surprise and novelty were also reported. By assessing the impact of flashbulb memories in this patient with AD, this paper offers a unique view into how such memories may trigger a considerable recall of context as well much subjective reliving.

Anticipating surprise: Using agent-based alternative futures simulation modeling to identify and map surprising fires in the Willamette Valley, Oregon USA

Treesearch

David Hulse; Allan Branscomb; Chris Enright; Bart Johnson; Cody Evers; John Bolte; Alan Ager

2016-01-01

This article offers a literature-supported conception and empirically grounded analysis of surprise by exploring the capacity of scenario-driven, agent-based simulation models to better anticipate it. Building on literature-derived definitions and typologies of surprise, and using results from a modeled 81,000 ha study area in a wildland-urban interface of western...

Recognizing vocal emotions in Mandarin Chinese: a validated database of Chinese vocal emotional stimuli.

PubMed

Liu, Pan; Pell, Marc D

2012-12-01

To establish a valid database of vocal emotional stimuli in Mandarin Chinese, a set of Chinese pseudosentences (i.e., semantically meaningless sentences that resembled real Chinese) were produced by four native Mandarin speakers to express seven emotional meanings: anger, disgust, fear, sadness, happiness, pleasant surprise, and neutrality. These expressions were identified by a group of native Mandarin listeners in a seven-alternative forced choice task, and items reaching a recognition rate of at least three times chance performance in the seven-choice task were selected as a valid database and then subjected to acoustic analysis. The results demonstrated expected variations in both perceptual and acoustic patterns of the seven vocal emotions in Mandarin. For instance, fear, anger, sadness, and neutrality were associated with relatively high recognition, whereas happiness, disgust, and pleasant surprise were recognized less accurately. Acoustically, anger and pleasant surprise exhibited relatively high mean f0 values and large variation in f0 and amplitude; in contrast, sadness, disgust, fear, and neutrality exhibited relatively low mean f0 values and small amplitude variations, and happiness exhibited a moderate mean f0 value and f0 variation. Emotional expressions varied systematically in speech rate and harmonics-to-noise ratio values as well. This validated database is available to the research community and will contribute to future studies of emotional prosody for a number of purposes. To access the database, please contact pan.liu@mail.mcgill.ca.

Eye movements reveal epistemic curiosity in human observers.

PubMed

Baranes, Adrien; Oudeyer, Pierre-Yves; Gottlieb, Jacqueline

2015-12-01

Saccadic (rapid) eye movements are primary means by which humans and non-human primates sample visual information. However, while saccadic decisions are intensively investigated in instrumental contexts where saccades guide subsequent actions, it is largely unknown how they may be influenced by curiosity - the intrinsic desire to learn. While saccades are sensitive to visual novelty and visual surprise, no study has examined their relation to epistemic curiosity - interest in symbolic, semantic information. To investigate this question, we tracked the eye movements of human observers while they read trivia questions and, after a brief delay, were visually given the answer. We show that higher curiosity was associated with earlier anticipatory orienting of gaze toward the answer location without changes in other metrics of saccades or fixations, and that these influences were distinct from those produced by variations in confidence and surprise. Across subjects, the enhancement of anticipatory gaze was correlated with measures of trait curiosity from personality questionnaires. Finally, a machine learning algorithm could predict curiosity in a cross-subject manner, relying primarily on statistical features of the gaze position before the answer onset and independently of covariations in confidence or surprise, suggesting potential practical applications for educational technologies, recommender systems and research in cognitive sciences. With this article, we provide full access to the annotated database allowing readers to reproduce the results. Epistemic curiosity produces specific effects on oculomotor anticipation that can be used to read out curiosity states. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Calculations of the variability of ice cloud radiative properties at selected solar wavelengths

NASA Technical Reports Server (NTRS)

Welch, R. M.; Zdunkowski, W. G.; Cox, S. K.

1980-01-01

This study shows that there is surprising little difference in values of reflectance, absorptance, and transmittance for many of the intermediate-size particle spectra. Particle size distributions with mode radii ranging from approximately 50 to 300 microns, irrespective of particle shape and nearly independent of the choice of size distribution representation, give relatively similar flux values. The very small particle sizes, however, have significantly larger values of reflectance and transmittance with corresponding smaller values of absorptance than do the larger particle sizes. The very large particle modes produce very small values of reflectance and transmittance along with very large values of absorptance. Such variations are particularly noticeable when plotted as a function of wavelength.

Understanding the West African monsoon variability and its remote effects: an illustration of the grid point nudging methodology

NASA Astrophysics Data System (ADS)

Bielli, Soline; Douville, Hervé; Pohl, Benjamin

2010-07-01

General circulation models still show deficiencies in simulating the basic features of the West African Monsoon at intraseasonal, seasonal and interannual timescales. It is however, difficult to disentangle the remote versus regional factors that contribute to such deficiencies, and to diagnose their possible consequences for the simulation of the global atmospheric variability. The aim of the present study is to address these questions using the so-called grid point nudging technique, where prognostic atmospheric fields are relaxed either inside or outside the West African Monsoon region toward the ERA40 reanalysis. This regional or quasi-global nudging is tested in ensembles of boreal summer simulations. The impact is evaluated first on the model climatology, then on intraseasonal timescales with an emphasis on North Atlantic/Europe weather regimes, and finally on interannual timescales. Results show that systematic biases in the model climatology over West Africa are mostly of regional origin and have a limited impact outside the domain. A clear impact is found however on the eddy component of the extratropical circulation, in particular over the North Atlantic/European sector. At intraseasonal timescale, the main regional biases also resist to the quasi-global nudging though their magnitude is reduced. Conversely, nudging the model over West Africa exerts a strong impact on the frequency of the two North Atlantic weather regimes that favor the occurrence of heat waves over Europe. Significant impacts are also found at interannual timescale. Not surprisingly, the quasi-global nudging allows the model to capture the variability of large-scale dynamical monsoon indices, but exerts a weaker control on rainfall variability suggesting the additional contribution of regional processes. Conversely, nudging the model toward West Africa suppresses the spurious ENSO teleconnection that is simulated over Europe in the control experiment, thereby emphasizing the relevance of a realistic West African monsoon simulation for seasonal prediction in the extratropics. Further experiments will be devoted to case studies aiming at a better understanding of regional processes governing the monsoon variability and of the possible monsoon teleconnections, especially over Europe.

Lumley's PODT definition of large eddies and a trio of numerical procedures. [Proper Orthogonal Decomposition Theorem

NASA Technical Reports Server (NTRS)

Payne, Fred R.

1992-01-01

Lumley's 1967 Moscow paper provided, for the first time, a completely rational definition of the physically-useful term 'large eddy', popular for a half-century. The numerical procedures based upon his results are: (1) PODT (Proper Orthogonal Decomposition Theorem), which extracts the Large Eddy structure of stochastic processes from physical or computer simulation two-point covariances, and 2) LEIM (Large-Eddy Interaction Model), a predictive scheme for the dynamical large eddies based upon higher order turbulence modeling. Earlier Lumley's work (1964) forms the basis for the final member of the triad of numerical procedures: this predicts the global neutral modes of turbulence which have surprising agreement with both structural eigenmodes and those obtained from the dynamical equations. The ultimate goal of improved engineering design tools for turbulence may be near at hand, partly due to the power and storage of 'supermicrocomputer' workstations finally becoming adequate for the demanding numerics of these procedures.

Of bits and wows: A Bayesian theory of surprise with applications to attention.

PubMed

Baldi, Pierre; Itti, Laurent

2010-06-01

The amount of information contained in a piece of data can be measured by the effect this data has on its observer. Fundamentally, this effect is to transform the observer's prior beliefs into posterior beliefs, according to Bayes theorem. Thus the amount of information can be measured in a natural way by the distance (relative entropy) between the prior and posterior distributions of the observer over the available space of hypotheses. This facet of information, termed "surprise", is important in dynamic situations where beliefs change, in particular during learning and adaptation. Surprise can often be computed analytically, for instance in the case of distributions from the exponential family, or it can be numerically approximated. During sequential Bayesian learning, surprise decreases as the inverse of the number of training examples. Theoretical properties of surprise are discussed, in particular how it differs and complements Shannon's definition of information. A computer vision neural network architecture is then presented capable of computing surprise over images and video stimuli. Hypothesizing that surprising data ought to attract natural or artificial attention systems, the output of this architecture is used in a psychophysical experiment to analyze human eye movements in the presence of natural video stimuli. Surprise is found to yield robust performance at predicting human gaze (ROC-like ordinal dominance score approximately 0.7 compared to approximately 0.8 for human inter-observer repeatability, approximately 0.6 for simpler intensity contrast-based predictor, and 0.5 for chance). The resulting theory of surprise is applicable across different spatio-temporal scales, modalities, and levels of abstraction. Copyright 2010 Elsevier Ltd. All rights reserved.

Wastewater Treatment Effluent Reduces the Abundance and Diversity of Benthic Bacterial Communities in Urban and Suburban Rivers

PubMed Central

Drury, Bradley; Rosi-Marshall, Emma

2013-01-01

In highly urbanized areas, wastewater treatment plant (WWTP) effluent can represent a significant component of freshwater ecosystems. As it is impossible for the composition of WWTP effluent to match the composition of the receiving system, the potential exists for effluent to significantly impact the chemical and biological characteristics of the receiving ecosystem. We assessed the impacts of WWTP effluent on the size, activity, and composition of benthic microbial communities by comparing two distinct field sites in the Chicago metropolitan region: a highly urbanized river receiving effluent from a large WWTP and a suburban river receiving effluent from a much smaller WWTP. At sites upstream of effluent input, the urban and suburban rivers differed significantly in chemical characteristics and in the composition of their sediment bacterial communities. Although effluent resulted in significant increases in inorganic nutrients in both rivers, surprisingly, it also resulted in significant decreases in the population size and diversity of sediment bacterial communities. Tag pyrosequencing of bacterial 16S rRNA genes revealed significant effects of effluent on sediment bacterial community composition in both rivers, including decreases in abundances of Deltaproteobacteria, Desulfococcus, Dechloromonas, and Chloroflexi sequences and increases in abundances of Nitrospirae and Sphingobacteriales sequences. The overall effect of the WWTP inputs was that the two rivers, which were distinct in chemical and biological properties upstream of the WWTPs, were almost indistinguishable downstream. These results suggest that WWTP effluent has the potential to reduce the natural variability that exists among river ecosystems and indicate that WWTP effluent may contribute to biotic homogenization. PMID:23315724

Controls on microalgal community structures in cryoconite holes upon high Arctic glaciers, Svalbard

NASA Astrophysics Data System (ADS)

Vonnahme, T. R.; Devetter, M.; Žárský, J. D.; Šabacká, M.; Elster, J.

2015-07-01

Glaciers are known to harbor surprisingly complex ecosystems. On their surface, distinct cylindrical holes filled with meltwater and sediments are considered as hot spots for microbial life. The present paper addresses possible biological interactions within the community of prokaryotic cyanobacteria and eukaryotic microalgae (microalgae) and relations to their potential grazers, additional to their environmental controls. Svalbard glaciers with substantial allochthonous input of material from local sources reveal high microalgal densities. Small valley glaciers with high sediment coverages and high impact of birds show high biomasses and support a high biological diversity. Invertebrate grazer densities do not show any significant negative correlation with microalgal abundances, but a positive correlation with eukaryotic microalgae. Most microalgae found in this study form large colonies (< 10 cells, or > 25 μm), which may protect them against invertebrate grazing. This finding rather indicates grazing as a positive control on eukaryotic microalgae by nutrient recycling. Density differences between the eukaryotic microalgae and prokaryotic cyanobacteria and their high distinction in RDA and PCA analyses indicate that these two groups are in strong contrast. Eukaryotic microalgae occurred mainly in unstable cryoconite holes with high sediment loads, high N : P ratios, and a high impact of bird guano, as a proxy for nutrients. In these environments autochthonous nitrogen fixation appears to be negligible. Selective wind transport of Oscillatoriales via soil and dust particles is proposed to explain their dominance in cryoconites further away from the glacier margins. We propose that, for the studied glaciers, nutrient levels related to recycling of limiting nutrients is the main factor driving variation in the community structure of microalgae and grazers.

The STARDUST Discovery Mission: Data from the Encounter with Comet Wild 2 and the Expected Sample Return

NASA Technical Reports Server (NTRS)

Sandford, Scott A.

2004-01-01

On January 2,2004, the STARDUST spacecraft made the closest ever flyby (236 km) of the nucleus of a comet - Comet Wild 2. During the fly by the spacecraft collected samples of dust from the coma of the comet. These samples will be returned to Earth on January 15,2006. After a brief preliminary examination to establish the nature of the returned samples, they will be made available to the general scientific community for study. In addition to its aerogel dust collector, the STARDUST spacecraft was also equipped with instruments that made in situ measurements of the comet during the flyby. These included several dust impact monitors, a mass spectrometer, and a camera. The spacecraft's communication system was also used to place dynamical constraints on the mass of the nucleus and the number of impacts the spacecraft had with large particles. The data taken by these instruments indicate that the spacecraft successfully captured coma samples. These instruments, particularly the camera, also demonstrated that Wild 2 is unlike any other object in the Solar System previously visited by a spacecraft. During my talk I will discuss the scientific goals of the STARDUST mission and provide an overview of its design and flight to date. I will then end with a description of the exciting data returned by the spacecraft during the recent encounter with Wild 2 and discuss what these data tell us about the nature of comets. It will probably come as no surprise that the encounter data raise as many (or more) new questions as they answer old ones.

Numerical Simulations of Silverpit Crater Collapse

NASA Technical Reports Server (NTRS)

Collins, G. S.; Ivanov, B. A.; Turtle, E. P.; Melosh, H. J.

2003-01-01

The Silverpit crater is a recently discovered, 60-65 Myr old complex crater, which lies buried beneath the North Sea, about 150 km east of Britain. High-resolution images of Silverpit's subsurface structure, provided by three-dimensional seismic reflection data, reveal an inner-crater morphology similar to that expected for a 5-8 km diameter terrestrial crater. The crater walls show evidence of terrace-style slumping and there is a distinct central uplift, which may have produced a central peak in the pristine crater morphology. However, Silverpit is not a typical 5-km diameter terrestrial crater, because it exhibits multiple, concentric rings outside the main cavity. External concentric rings are normally associated with much larger impact structures, for example Chicxulub on Earth, or Orientale on the Moon. Furthermore, external rings associated with large impacts on the terrestrial planets and moons are widely-spaced, predominantly inwardly-facing, asymmetric scarps. However, the seismic data show that the external rings at Silverpit represent closely-spaced, concentric faultbound graben, with both inwardly and outwardly facing fault-scarps. This type of multi-ring structure directly analogous to the Valhalla-type multi-ring basins found on the icy satellites. Thus, the presence and style of the multiple rings at Silverpit is surprising given both the size of the crater and its planetary setting. A further curiosity of the Silverpit structure is that the external concentric rings appear to be extensional features on the West side of the crater and compressional features on the East side. The crater also lies in a local depression, thought to be created by postimpact movement of a salt layer buried beneath the crater.

Impact craters on Venus: An overview from Magellan observations

NASA Technical Reports Server (NTRS)

Schaber, G. G.; Strom, R. G.; Moore, H. J.; Soderblom, L. A.; Kirk, R. L.; Chadwick, D. J.; Dawson, D. D.; Gaddis, L. R.; Boyce, J. M.; Russell, J.

1992-01-01

Magellan has revealed an ensemble of impact craters on Venus that is unique in many important ways. We have compiled a database describing 842 craters on 89 percent of the planet's surface mapped through orbit 2578 (the craters range in diameter from 1.5 to 280 km). We have studied the distribution, size-frequency, morphology, and geology of these craters both in aggregate and, for some craters, in more detail. We have found the following: (1) the spatial distribution of craters is highly uniform; (2) the size-density distribution of craters with diameters greater than or equal to 35 km is consistent with a 'production' population having a surprisingly young age of about 0.5 Ga (based on the estimated population of Venus-crossing asteroids); (3) the spectrum of crater modification differs greatly from that on other planets--62 percent of all craters are pristine, only 4 percent volcanically embayed, and the remainder affected by tectonism, but none are severely and progressively depleted based on size-density distribution extrapolated from larger craters; (4) large craters have a progression of morphologies generally similar to those on other planets, but small craters are typically irregular or multiple rather than bowl shaped; (5) diffuse radar-bright or -dark features surround some craters, and about 370 similar diffuse 'splotches' with no central crater are observed whose size-density distribution is similar to that of small craters; and (6) other features unique to Venus include radar-bright or -dark parabolic arcs opening westward and extensive outflows originating in crater ejecta.

Chinese Soot on a Vietnamese Soup

NASA Astrophysics Data System (ADS)

Mari, X.

2015-12-01

Black Carbon (BC) is an aerosol emitted as soot during biomass burning and fossil fuels combustion together with other carbonaceous aerosols such as organic carbon (OC) and polyaromatic hydrocarbons (PAHs). While the impacts of BC on health and climate have been studied for many years, studies about its deposition and impact on marine ecosystems are scares. This is rather surprising considering that a large fraction of atmospheric BC deposits on the surface of the ocean via dry or wet deposition. On a global scale, deposition on the ocean is about 45 Tg C per year, with higher fluxes in the northern hemisphere and in inter-tropical regions, following the occurrence of the hot-spots of concentration. In the present study conducted on shore, in Haiphong and Halong cities, North Vietnam, we measured the seasonal variations of atmospheric BC, OC and PAHs during a complete annual cycle. The presentation will discuss the atmospheric results in terms of seasonal variability and sources. Inputs to the marine system are higher during the dry season, concomitantly with the arrival of air masses enriched in BC coming from the North. However, the carbon fingerprint can significantly differ at shorter time periods depending on the air mass pathway and speed. Our work leads to the characterization and the determination of the relative contribution of more specific sources like local traffic, which includes tourism and fishing boats, coal dust emitted from the nearby mine, and long-range transported aerosols. This variable input of carbonaceous aerosols might have consequences for the cycling and the repartition of carbon and nutrients in the marine ecosystem of Halong Bay.

Whether or not to eat: A controlled laboratory study of discriminative cueing effects on food intake in humans.

PubMed

Ridley-Siegert, Thomas L; Crombag, Hans S; Yeomans, Martin R

2015-12-01

There is a wealth of data showing a large impact of food cues on human ingestion, yet most studies use pictures of food where the precise nature of the associations between the cue and food is unclear. To test whether novel cues which were associated with the opportunity of winning access to food images could also impact ingestion, 63 participants participated in a game in which novel visual cues signalled whether responding on a keyboard would win (a picture of) chocolate, crisps, or nothing. Thirty minutes later, participants were given an ad libitum snack-intake test during which the chocolate-paired cue, the crisp-paired cue, the non-winning cue and no cue were presented as labels on the food containers. The presence of these cues significantly altered overall intake of the snack foods; participants presented with food labelled with the cue that had been associated with winning chocolate ate significantly more than participants who had been given the same products labelled with the cue associated with winning nothing, and in the presence of the cue signalling the absence of food reward participants tended to eat less than all other conditions. Surprisingly, cue-dependent changes in food consumption were unaffected by participants' level of contingency awareness. These results suggest that visual cues that have been pre-associated with winning, but not consuming, a liked food reward modify food intake consistent with current ideas that the abundance of food associated cues may be one factor underlying the 'obesogenic environment'. Copyright © 2015 Elsevier Inc. All rights reserved.

The Effect of Monitoring: How Data Collection Type and Frequency Boosts Participation and the Adoption of Best Practices in a Coffee Agronomy Training Program in Rwanda.

PubMed

Gathani, Sachin; Gomez, Maria Paula; Sabates, Ricardo; Stoelinga, Dimitri

2015-12-01

The impact of surveying on individuals' behavior and decision making has been widely studied in academic literature on market research but not so much the impact of monitoring on economic development interventions. To estimate whether different monitoring strategies lead to improvement in participation levels and adoption of best practices for coffee production for farmer who participated in TechnoServe Agronomy Training Program in Rwanda. Farmers were identified randomly for monitoring purposes to belong to two different groups and then selected depending on the additional criterion of having productive coffee trees. We estimate treatment-on-the-treated and intention-to-treat effects on training attendance rates and farmers best-practice adoptions using difference-in-differences estimation techniques. Farmers were randomly identified to a high or low monitoring with different type and frequency of data collection and selected if they had productive coffee trees as part of the monitoring strategy. Attendance to training sessions by all farmers in the program and best-practice adoption data for improving coffee yield. We find that monitoring led to surprisingly large increases in farmer participation levels in the project and also improved best-practice adoption rates. We also find that higher frequency of data collection has long-lasting effects and are more pronounced for low-attendance farmers. Monitoring not only provides more data and a better understanding of project dynamics, which in turn can help improve design, but can also improve processes and outcomes, in particular for the least engaged. © The Author(s) 2016.

Influence of strain on dislocation core in silicon

NASA Astrophysics Data System (ADS)

Pizzagalli, L.; Godet, J.; Brochard, S.

2018-05-01

First principles, density functional-based tight binding and semi-empirical interatomic potentials calculations are performed to analyse the influence of large strains on the structure and stability of a 60? dislocation in silicon. Such strains typically arise during the mechanical testing of nanostructures like nanopillars or nanoparticles. We focus on bi-axial strains in the plane normal to the dislocation line. Our calculations surprisingly reveal that the dislocation core structure largely depends on the applied strain, for strain levels of about 5%. In the particular case of bi-axial compression, the transformation of the dislocation to a locally disordered configuration occurs for similar strain magnitudes. The formation of an opening, however, requires larger strains, of about 7.5%. Furthermore, our results suggest that electronic structure methods should be favoured to model dislocation cores in case of large strains whenever possible.

Never Let the Opportunity to Prepare for a Crisis Go to Waste: The Need for Proactive Measures in the Asia-Pacific Region to Mitigate the Impacts of Climate Change

DTIC Science & Technology

2015-05-21

mitigation plan in place. In the long term, it is likely that the Filipinos will contend with both rising sea levels and acidification of the ocean . The... acidification of the oceans will likely have a deleterious effect on fisheries, increasing the potential for food...Persian Gulf to both the South China Sea and the Pacific Ocean . 34 With such enormous economic value, it should come as no surprise that nations

Mass-metallicity relation for AKARI-FMOS infrared luminous galaxies at z ~ 0.9

NASA Astrophysics Data System (ADS)

Oi, Nagisa; Matsuhara, Hideo; Goto, Tomotsugu; Pearson, Chris; Buat, Véronique; Malkan, Matthew A.

We study the mass-metallicity relation and fundamental relation (FMR) for infrared bright galaxies (IR galaxies) at z ~ 0.9 discovered by AKARI NEP-Deep survey. The main result of this work is that metallicity of IR galaxies surprisingly match optical selected galaxies at a given mass even their star formation rates are different, which may imply that optical and IR selected galaxies follow similar star formation histories, and the starbursts in the IR galaxies do not give a strong impact in changing metallicity because of the short duration time.

Earth Observations taken by Expedition 47 Crewmember.

NASA Image and Video Library

2016-03-26

ISS047e022280 (03/26/2016) --- This interesting Earth observation image from the International Space Station seems an abstract painting but is really the outskirts of the Namib Desert in southwest Africa. One of the oldest and largest deserts in the world, the Namib stretches inland from the Atlantic Ocean, covering large swathes of Namibia and parts of Angola and South Africa. This arid hotspot surprisingly supports a diverse number of plants and animals, some of which are found nowhere else in the world.

Teaching and physics education research: bridging the gap.

PubMed

Fraser, James M; Timan, Anneke L; Miller, Kelly; Dowd, Jason E; Tucker, Laura; Mazur, Eric

2014-03-01

Physics faculty, experts in evidence-based research, often rely on anecdotal experience to guide their teaching practices. Adoption of research-based instructional strategies is surprisingly low, despite the large body of physics education research (PER) and strong dissemination effort of PER researchers and innovators. Evidence-based PER has validated specific non-traditional teaching practices, but many faculty raise valuable concerns toward their applicability. We address these concerns and identify future studies required to overcome the gap between research and practice.

Unlikely Fluctuations and Non-Equilibrium Work Theorems-A Simple Example.

PubMed

Muzikar, Paul

2016-06-30

An exciting development in statistical mechanics has been the elucidation of a series of surprising equalities involving the work done during a nonequilibrium process. Astumian has presented an elegant example of such an equality, involving a colloidal particle undergoing Brownian motion in the presence of gravity. We analyze this example; its simplicity, and its link to geometric Brownian motion, allows us to clarify the inner workings of the equality. Our analysis explicitly shows the important role played by large, unlikely fluctuations.

Detection and Interpretation of Low-Level and High-Level Surprising and Important Events in Large-Scale Data Streams

DTIC Science & Technology

2016-06-28

Likewise, we have developed a new general theory of relevance that quanti - fies how new data observations may or not affect an observer’s beliefs about how...which suggests that relevance is not an inherent attribute but rather is dependent on the knowledge or beliefs of the subject evaluating the...subjects. This allowed us to evaluate the accuracy of each person as the number of image pairs for which they selected the majority image. The average

New surprises in the largest magnetosphere of our solar system.

PubMed

Krupp, Norbert

2007-10-12

En route to its ultimate rendezvous with Pluto, the New Horizons spacecraft passed through the magnetic and plasma environment of Jupiter in February 2007. Onboard instruments collected high-resolution images, spectroscopic data, and information about charged particles. The results have revealed unusual structure and variation in Jupiter's plasma and large plasmoids that travel down the magnetotail. Data on Jupiter's aurora provide details of the interaction with the solar wind, and a major volcanic eruption from the moon Io was observed during the encounter.

The inorganic constituents of echinoderms

USGS Publications Warehouse

Clarke, F.W.; Wheeler, W.C.

1915-01-01

In a recent paper on the composition of crinoid skeletons we showed that crinoids contain large quantities of magnesia, and that its proportion varies with the temperature of the water in which the creatures live. This result was so novel and surprising that it seemed desirable to examine other echinoderms and to ascertain whether they showed the same characteristics and regularity. A number of sea urchins and starfishes were therefore studied, their inorganic constituents being analyzed in the same manner as those of the crinoids

Comment on ``Wealth condensation in Pareto macroeconomies''

NASA Astrophysics Data System (ADS)

Huang, Ding-Wei

2003-10-01

In a recent study of the Pareto macroeconomy [Phys. Rev. E 65, 026102 (2002)], a surprising deviation to the power law distribution of the large wealths is reported. We comment that such a “corruption” phenomenon can be reproduced in a much simplified framework. The corruption disappears when the small wealths are further included in a mean-field treatment. The constraint of the total-wealth conservation leads to a cutoff in the power-law tail, in contrast to the prominent enhancement reported previously.

Equations of State: Gateway to Planetary Origin and Evolution (Invited)

NASA Astrophysics Data System (ADS)

Melosh, J.

2013-12-01

Research over the past decades has shown that collisions between solid bodies govern many crucial phases of planetary origin and evolution. The accretion of the terrestrial planets was punctuated by planetary-scale impacts that generated deep magma oceans, ejected primary atmospheres and probably created the moons of Earth and Pluto. Several extrasolar planetary systems are filled with silicate vapor and condensed 'tektites', probably attesting to recent giant collisions. Even now, long after the solar system settled down from its violent birth, a large asteroid impact wiped out the dinosaurs, while other impacts may have played a role in the origin of life on Earth and perhaps Mars, while maintaining a steady exchange of small meteorites between the terrestrial planets and our moon. Most of these events are beyond the scale at which experiments are possible, so that our main research tool is computer simulation, constrained by the laws of physics and the behavior of materials during high-speed impact. Typical solar system impact velocities range from a few km/s in the outer solar system to 10s of km/s in the inner system. Extrasolar planetary systems expand that range to 100s of km/sec typical of the tightly clustered planetary systems now observed. Although computer codes themselves are currently reaching a high degree of sophistication, we still rely on experimental studies to determine the Equations of State (EoS) of materials critical for the correct simulation of impact processes. The recent expansion of the range of pressures available for study, from a few 100 GPa accessible with light gas guns up to a few TPa from current high energy accelerators now opens experimental access to the full velocity range of interest in our solar system. The results are a surprise: several groups in both the USA and Japan have found that silicates and even iron melt and vaporize much more easily in an impact than previously anticipated. The importance of these findings is illustrated by the impact origin of our Moon. Computer simulations that do not take account of the liquid/vapor phase change are unable to retain any material in orbit around the Earth after a planetary impact. A purely gaseous disk around the Earth is wracked by gravitational instabilities and soon collapses back onto the Earth. Only if the silicate EoS also includes a liquid phase can a disk remain stable long enough to condense into a moon. The implications of this new-found ease of vaporization have yet to be fully explored, but it seems clear that current ideas must undergo extensive revision. More melt and vapor production in impacts implies much larger volume changes of the impacted materials and hence more energetic post-impact expansion. EoSs are thus of vital importance to our understanding of the evolution of planetary systems. Computer simulations can (and must!) substitute for experiments for many aspects of large planetary collisions, but so far experiments are leading theory in accurate determination of equations of state. Yet, the fidelity of the computer simulations to Nature can be only as good as the accuracy of the inputs, making further experimental study of EoS a central task in the exploration and elucidation of our solar system and of planetary systems in general.

Slow Impacts on Strong Targets Bring on the Heat

NASA Astrophysics Data System (ADS)

Melosh, H. J.; Ivanov, B. A.

2018-03-01

An important new paper by Kurosawa and Genda (2017, https://doi.org/10.1002/2017GL076285) reports a previously overlooked source of heating in low velocity meteorite impacts. Plastic deformation of the pressure-strengthened rocks behind the shock front dissipates energy, which appears as heat in addition to that generated across the shock wave itself. This heat source has surprisingly escaped explicit attention for decades: First, because it is minimized in the geometry typically chosen for laboratory experiments; and second because it is most important in rocks, and less so for the metals usually used in experiments. Nevertheless, modern numerical computer codes that include strength do compute this heating correctly. This raises the philosophical question of whether we can claim to understand some process just because our computer codes compute the results correctly.

Long-term impacts of ocean acidification on parent sea urchins and subsequent recruitment

NASA Astrophysics Data System (ADS)

Suckling, C. C.; Clark, M. S.; Peck, L. S.; Harper, E.; Beveridge, C.; Brunner, L.; Hughes, A. D.; Davies, A. J.; Cook, E. J.

2011-12-01

Our oceans have become progressively more acidic over recent decades, yet we still know little about how this will affect marine biota. To survive, organisms must acclimate and adapt. Surprisingly no studies have investigated this beyond focussing on limited parts of the life-cycle and without pre-exposing parents to reduced pH conditions. Using echinoids, we present our findings on the long-term impacts of exposing parents to forecasted reduced pH conditions (IPCC IS92a scenario; ~1000 ppm CO2) and the consequences on their reproductive success through to recruitment. This study will contribute significantly towards our understanding of organismal reactions towards ocean acidification and determine whether they have intergenerational capacities to acclimate and adapt towards conditions well beyond natural-rates of ocean acidification.

Seeing the world through non rose-colored glasses: anxiety and the amygdala response to blended expressions

PubMed Central

Bishop, Sonia J.; Aguirre, Geoffrey K.; Nunez-Elizalde, Anwar O.; Toker, Daniel

2015-01-01

Anxious individuals have a greater tendency to categorize faces with ambiguous emotional expressions as fearful (Richards et al., 2002). These behavioral findings might reflect anxiety-related biases in stimulus representation within the human amygdala. Here, we used functional magnetic resonance imaging (fMRI) together with a continuous adaptation design to investigate the representation of faces from three expression continua (surprise-fear, sadness-fear, and surprise-sadness) within the amygdala and other brain regions implicated in face processing. Fifty-four healthy adult participants completed a face expression categorization task. Nineteen of these participants also viewed the same expressions presented using type 1 index 1 sequences while fMRI data were acquired. Behavioral analyses revealed an anxiety-related categorization bias in the surprise-fear continuum alone. Here, elevated anxiety was associated with a more rapid transition from surprise to fear responses as a function of percentage fear in the face presented, leading to increased fear categorizations for faces with a mid-way blend of surprise and fear. fMRI analyses revealed that high trait anxious participants also showed greater representational similarity, as indexed by greater adaptation of the Blood Oxygenation Level Dependent (BOLD) signal, between 50/50 surprise/fear expression blends and faces from the fear end of the surprise-fear continuum in both the right amygdala and right fusiform face area (FFA). No equivalent biases were observed for the other expression continua. These findings suggest that anxiety-related biases in the processing of expressions intermediate between surprise and fear may be linked to differential representation of these stimuli in the amygdala and FFA. The absence of anxiety-related biases for the sad-fear continuum might reflect intermediate expressions from the surprise-fear continuum being most ambiguous in threat-relevance. PMID:25870551

Tetanus toxoid immunization to reduce mortality from neonatal tetanus

PubMed Central

Blencowe, Hannah; Lawn, Joy; Vandelaer, Jos; Roper, Martha

2010-01-01

Background Neonatal tetanus remains an important and preventable cause of neonatal mortality globally. Large reductions in neonatal tetanus deaths have been reported following major increases in the coverage of tetanus toxoid immunization, yet the level of evidence for the mortality effect of tetanus toxoid immunization is surprisingly weak with only two trials considered in a Cochrane review. Objective To review the evidence for and estimate the effect on neonatal tetanus mortality of immunization with tetanus toxoid of pregnant women, or women of childbearing age. Methods We conducted a systematic review of multiple databases. Standardized abstraction forms were used. Individual study quality and the overall quality of evidence were assessed using an adaptation of the GRADE approach. Meta-analyses were performed. Results Only one randomised controlled trial (RCT) and one well-controlled cohort study were identified, which met inclusion criteria for meta-analysis. Immunization of pregnant women or women of childbearing age with at least two doses of tetanus toxoid is estimated to reduce mortality from neonatal tetanus by 94% [95% confidence interval (CI) 80–98%]. Additionally, another RCT with a case definition based on day of death, 3 case–control studies and 1 before-and-after study gave consistent results. Based on the consistency of the mortality data, the very large effect size and that the data are all from low/middle-income countries, the overall quality of the evidence was judged to be moderate. Conclusion This review uses a standard approach to provide a transparent estimate of the high impact of tetanus toxoid immunization on neonatal tetanus. PMID:20348112

Manpower planning in periodontology--how many specialists do we need?

PubMed

Griffiths, G S; Preshaw, P M

2014-10-01

Given that one of the major focus points within this issue of the journal is 'practical periodontal medicine' and the relationship between periodontal disease and systemic chronic diseases, it is surprising that we have no indication of the manpower required to secure better oral and general health in this field. Despite many of the heralded improvements in dental health reported in the Adult Dental Health Survey 2009, as monitored by the falling rates of edentulous subjects and decayed, missing and filled teeth (DMF), the overall increase between 1998 and 2009 in the number of subjects with deep pockets from 6% to 8% has largely gone unnoticed! This is a major concern given that most other indicators of oral health have improved over this time period. Furthermore, the tissue damage associated with periodontitis is largely irreversible, and has consequences not only for oral function and quality of life, but also may adversely impact on aspects of general health. This article aims to highlight why we need specialists in periodontics, which patients should be referred to them, how big a problem periodontal disease is and how many specialists in periodontics would be required to meet this treatment need. Estimates are made using the information gained from the Adult Dental Health Survey 2009 and the Office for National Statistics 2011 census, along with estimates of the average patient pool managed within specialist periodontal practices. However, the paper emphasises that these are estimates based on incomplete information which would be necessary to allow more complete models of manpower planning to be used.

Community cost-benefit discussions that launched the Camino Verde intervention in Nicaragua.

PubMed

Hernandez-Alvarez, Carlos; Arosteguí, Jorge; Suazo-Laguna, Harold; Reyes, Rosa Maria; Coloma, Josefina; Harris, Eva; Andersson, Neil; Ledogar, Robert J

2017-05-30

Recent literature on community intervention research stresses system change as a condition for durable impact. This involves highly participatory social processes leading to behavioural change. Before launching the intervention in the Nicaraguan arm of Camino Verde, a cluster-randomised controlled trial to show that pesticide-free community mobilisation adds effectiveness to conventional dengue controls, we held structured discussions with leaders of intervention communities on costs of dengue illness and dengue control measures taken by both government and households. These discussions were the first step in an effort at Socialising Evidence for Participatory Action (SEPA), a community mobilisation method used successfully in other contexts. Theoretical grounding came from community psychology and behavioural economics. The leaders expressed surprise at how large and unexpected an economic burden dengue places on households. They also acknowledged that large investments of household and government resources to combat dengue have not had the expected results. Many were not ready to see community preventive measures as a substitute for chemical controls but all the leaders approved the formation of "brigades" to promote chemical-free household control efforts in their own communities. Discussions centred on household budget decisions provide a good entry point for researchers to engage with communities, especially when the evidence showed that current expenditures were providing a poor return. People became motivated not only to search for ways to reduce their costs but also to question the current response to the problem in question. This in turn helped create conditions favourable to community mobilisation for change. ISRCTN27581154 .

Surprise

ERIC Educational Resources Information Center

Adler, Jonathan E.

2008-01-01

Surprise is of great value for learning, especially in cases where deep-seated preconceptions and assumptions are upset by vivid demonstrations. In this essay, Jonathan Adler explores the ways in which surprise positively affects us and serves as a valuable tool for motivating learning. Adler considers how students' attention is aroused and…

Surprise influences hindsight-foresight differences in temporal judgments of animated automobile accidents.

PubMed

Calvillo, Dustin P; Gomes, Dayna M

2011-04-01

The hindsight bias occurs when people view an outcome as more foreseeable than it actually was. The role of an outcome's initial surprise in the hindsight bias was examined using animations of automobile accidents. Twenty-six participants rated the initial surprise of accidents' occurring in eight animations. An additional 84 participants viewed these animations in one of two conditions: Half stopped the animations when they were certain an accident would occur (i.e., in foresight), and the other half watched the entire animations first and then stopped the animations when they thought that a naïve viewer would be certain that an accident would occur (i.e., in hindsight). When the accidents were low in initial surprise, there were no foresight-hindsight differences; when initial surprise was medium, there was a hindsight bias; and when initial surprise was high, there was a reversed hindsight bias. The results are consistent with a sense-making model of hindsight bias.

Fishing down the largest coral reef fish species.

PubMed

Fenner, Douglas

2014-07-15

Studies on remote, uninhabited, near-pristine reefs have revealed surprisingly large populations of large reef fish. Locations such as the northwestern Hawaiian Islands, northern Marianas Islands, Line Islands, U.S. remote Pacific Islands, Cocos-Keeling Atoll and Chagos archipelago have much higher reef fish biomass than islands and reefs near people. Much of the high biomass of most remote reef fish communities lies in the largest species, such as sharks, bumphead parrots, giant trevally, and humphead wrasse. Some, such as sharks and giant trevally, are apex predators, but others such as bumphead parrots and humphead wrasse, are not. At many locations, decreases in large reef fish species have been attributed to fishing. Fishing is well known to remove the largest fish first, and a quantitative measure of vulnerability to fishing indicates that large reef fish species are much more vulnerable to fishing than small fish. The removal of large reef fish by fishing parallels the extinction of terrestrial megafauna by early humans. However large reef fish have great value for various ecological roles and for reef tourism. Copyright © 2014 Elsevier Ltd. All rights reserved.

Ultraviolet surprise: Efficient soft x-ray high-harmonic generation in multiply ionized plasmas.

PubMed

Popmintchev, Dimitar; Hernández-García, Carlos; Dollar, Franklin; Mancuso, Christopher; Pérez-Hernández, Jose A; Chen, Ming-Chang; Hankla, Amelia; Gao, Xiaohui; Shim, Bonggu; Gaeta, Alexander L; Tarazkar, Maryam; Romanov, Dmitri A; Levis, Robert J; Gaffney, Jim A; Foord, Mark; Libby, Stephen B; Jaron-Becker, Agnieszka; Becker, Andreas; Plaja, Luis; Murnane, Margaret M; Kapteyn, Henry C; Popmintchev, Tenio

2015-12-04

High-harmonic generation is a universal response of matter to strong femtosecond laser fields, coherently upconverting light to much shorter wavelengths. Optimizing the conversion of laser light into soft x-rays typically demands a trade-off between two competing factors. Because of reduced quantum diffusion of the radiating electron wave function, the emission from each species is highest when a short-wavelength ultraviolet driving laser is used. However, phase matching--the constructive addition of x-ray waves from a large number of atoms--favors longer-wavelength mid-infrared lasers. We identified a regime of high-harmonic generation driven by 40-cycle ultraviolet lasers in waveguides that can generate bright beams in the soft x-ray region of the spectrum, up to photon energies of 280 electron volts. Surprisingly, the high ultraviolet refractive indices of both neutral atoms and ions enabled effective phase matching, even in a multiply ionized plasma. We observed harmonics with very narrow linewidths, while calculations show that the x-rays emerge as nearly time-bandwidth-limited pulse trains of ~100 attoseconds. Copyright © 2015, American Association for the Advancement of Science.

The Ultraviolet Surprise. Efficient Soft X-Ray High Harmonic Generation in Multiply-Ionized Plasmas

DOE PAGES

Popmintchev, Dimitar; Hernandez-Garcia, Carlos; Dollar, Franklin; ...

2015-12-04

High-harmonic generation is a universal response of matter to strong femtosecond laser fields, coherently upconverting light to much shorter wavelengths. Optimizing the conversion of laser light into soft x-rays typically demands a trade-off between two competing factors. Reduced quantum diffusion of the radiating electron wave function results in emission from each species which is highest when a short-wavelength ultraviolet driving laser is used. But, phase matching—the constructive addition of x-ray waves from a large number of atoms—favors longer-wavelength mid-infrared lasers. We identified a regime of high-harmonic generation driven by 40-cycle ultraviolet lasers in waveguides that can generate bright beams inmore » the soft x-ray region of the spectrum, up to photon energies of 280 electron volts. Surprisingly, the high ultraviolet refractive indices of both neutral atoms and ions enabled effective phase matching, even in a multiply ionized plasma. We observed harmonics with very narrow linewidths, while calculations show that the x-rays emerge as nearly time-bandwidth–limited pulse trains of ~100 attoseconds.« less

Swarm intelligence: when uncertainty meets conflict.

PubMed

Conradt, Larissa; List, Christian; Roper, Timothy J

2013-11-01

Good decision making is important for the survival and fitness of stakeholders, but decisions usually involve uncertainty and conflict. We know surprisingly little about profitable decision-making strategies in conflict situations. On the one hand, sharing decisions with others can pool information and decrease uncertainty (swarm intelligence). On the other hand, sharing decisions can hand influence to individuals whose goals conflict. Thus, when should an animal share decisions with others? Using a theoretical model, we show that, contrary to intuition, decision sharing by animals with conflicting goals often increases individual gains as well as decision accuracy. Thus, conflict-far from hampering effective decision making-can improve decision outcomes for all stakeholders, as long as they share large-scale goals. In contrast, decisions shared by animals without conflict were often surprisingly poor. The underlying mechanism is that animals with conflicting goals are less correlated in individual choice errors. These results provide a strong argument in the interest of all stakeholders for not excluding other (e.g., minority) factions from collective decisions. The observed benefits of including diverse factions among the decision makers could also be relevant to human collective decision making.

Children, wired – for better and for worse

PubMed Central

Bavelier, Daphne; Green, C. Shawn; Dye, Matthew W. G.

2011-01-01

Children today encounter and utilize technology constantly both at home and in school. Television, DVDs, video games, the internet, cell phones and PDAs – all now play a formative role in many children’s development. Given that the term “technology” subsumes a large variety of somewhat independent items, it may not be surprising that current research indicates causes for both optimism and for concern that depend upon the content of the technology, the context in which the technology immerses the user, and the developmental stage of the user. Furthermore, because the field is still, relative to other natural sciences, in its infancy, results can be surprising. For example, video games designed to be reasonably mindless result in a widespread enhancement of various abilities, acting, we will argue, as exemplary learning tools. Counter-intuitive outcomes like these, besides being practically relevant, challenge and eventually lead to refinement of theories concerning fundamental principles of brain plasticity and learning. Thus, technology offers us a range of tools, not just for promoting certain behaviors, but also for studying the neural bases of learning and development. PMID:20826302

Air Pollution, Greenhouse Gases and Climate Change

NASA Astrophysics Data System (ADS)

Ramanathan, V.

2007-12-01

The global build up of greenhouse gases (GHGs), is the most significant environmental issue facing the planet. GHGs warm the surface and the atmosphere with significant implications for, rainfall, retreat of glaciers and sea ice, sea level, among other factors. What is less recognized, however, is a comparably major global problem dealing with air pollution. Until about ten years ago, air pollution was thought to be just an urban or a local problem. But new data have revealed that, due to fast long range transport, air pollution is transported across continents and ocean basins, resulting in trans-oceanic and trans-continental plumes of atmospheric brown clouds (ABCs) containing sub micron size particles, i.e, aerosols. ABCs intercept sunlight by absorbing as well as reflecting it, both of which lead to a large surface dimming. The dimming effect is enhanced further because aerosols nucleate more cloud drops which makes the clouds reflect more solar radiation. While the solar heating at the surface is reduced by aerosols in ABCs, the atmospheric solar heating increases due to soot solar absorption. The net difference between the dimming and the atmospheric solar heating is estimated be negative which contributes to a global cooling effect. The global cooling from this negative ABC forcing may have masked as much as 50% of the warming due to GHGs. We will identify regional and mega-city hot spots of ABCs. Long range transport from these hot spots gives rise to wide spread plumes over the adjacent oceans. Such a pattern of regionally concentrated surface dimming and atmospheric solar heating, accompanied by wide spread dimming over the oceans, gives rise to large regional effects. Only during the last decade, we have begun to comprehend the surprisingly large regional impacts. The large north-south gradient in the ABC dimming has altered the north-south gradients in sea surface temperatures, which in turn has been shown by models to decrease rainfall over the continents. The uncertainties in our understanding of the ABC effects are large, but we are discovering new ways in which human activities are changing the climate and the environment.

The Complicated Geologic History of Asteroid 4 Vesta

NASA Astrophysics Data System (ADS)

Taylor, G. J.

2009-06-01

Planetary scientists are pretty sure that almost all of the HED meteorites come from the fourth-largest asteroid, 4 Vesta. HED stands for the three types of rocks that make up the group. As cosmochemists have studied the meteorites over the years, their view of the geologic history of the asteroid has become progressively more complicated. Jean-Alix Barrat and Marcel Bohn (CNRS and University of Brest, France), Philippe Gillet (CNRS and Ecole Normale Supérieure de Lyon, France), and Akira Yamaguchi (National Institute of Polar Research, Tokyo, Japan) have found that Vesta is even more complicated--and interesting--than we thought. Barrat and his colleagues analyzed impact-produced glass spherules and fragments in several howardites (mixtures of the two other main types, eucrites and diogenites). Not surprisingly, most of the glasses have compositions similar to eucrites, which are basalts, or mixtures of them with diogenites, but a few are surprisingly rich in silicon and potassium (expressed as the percentages of SiO2 and K2O, respectively). In fact, the concentrations of these oxides are similar to granites, compositionally far from basalt. Their manufacture requires extensive crystallization of magma. Combined with a more subtle variation among the basalts, the emerging picture is one that includes formation of a basaltic crust, partial melting of parts of the crust, mixing of those melts with some (not all) magmas as they migrated through the crust, and extensive crystallization of magma bodies to produce residual magma resembling granites. On top of that, Vestan rocks were thermally metamorphosed and battered and mixed by impacts. A pretty complicated little planetary body!

A Bayesian additive model for understanding public transport usage in special events.

PubMed

Rodrigues, Filipe; Borysov, Stanislav; Ribeiro, Bernardete; Pereira, Francisco

2016-12-02

Public special events, like sports games, concerts and festivals are well known to create disruptions in transportation systems, often catching the operators by surprise. Although these are usually planned well in advance, their impact is difficult to predict, even when organisers and transportation operators coordinate. The problem highly increases when several events happen concurrently. To solve these problems, costly processes, heavily reliant on manual search and personal experience, are usual practice in large cities like Singapore, London or Tokyo. This paper presents a Bayesian additive model with Gaussian process components that combines smart card records from public transport with context information about events that is continuously mined from the Web. We develop an efficient approximate inference algorithm using expectation propagation, which allows us to predict the total number of public transportation trips to the special event areas, thereby contributing to a more adaptive transportation system. Furthermore, for multiple concurrent event scenarios, the proposed algorithm is able to disaggregate gross trip counts into their most likely components related to specific events and routine behavior. Using real data from Singapore, we show that the presented model outperforms the best baseline model by up to 26% in R2 and also has explanatory power for its individual components.

Facing the crowd: intruder pressure, within-group competition, and the resolution of conflicts over group-membership

PubMed Central

Port, Markus; Johnstone, Rufus A

2013-01-01

Recent theory in social evolution has been mainly concerned with competition and cooperation within social groups of animals and their impact on the stability of those groups. Much less attention has been paid to conflicts arising as a result of solitary floaters (outsiders) attempting to join groups of established residents (insiders). We model such conflicts over group-membership using a demographically explicit approach in which the rates of births and deaths in a population determine the availability of group-vacancies and the number of floaters competing over these vacancies. We find that the outcome of within-group competition, reflected in the partitioning of reproduction among group members, exerts surprisingly little influence on the resolution of insider-outsider conflict. The outcome of such conflict is also largely unaffected by differences in resource holding potential between insiders and outsiders. By contrast, whether or not groups form is mainly determined by demographic factors (variation in vital rates such as fecundity and mortality) and the resulting population dynamics. In particular, at high floater densities territory defense becomes too costly, and groups form because insiders give in to the intruder pressure imposed on them by outsiders. We emphasize the importance of insider-outsider conflicts in social evolution theory and highlight avenues for future research. PMID:23762508

Disentangling the Impact of Social Groups on Response Times and Movement Dynamics in Evacuations

PubMed Central

Bode, Nikolai W. F.; Holl, Stefan; Mehner, Wolfgang; Seyfried, Armin

2015-01-01

Crowd evacuations are paradigmatic examples for collective behaviour, as interactions between individuals lead to the overall movement dynamics. Approaches assuming that all individuals interact in the same way have significantly improved our understanding of pedestrian crowd evacuations. However, this scenario is unlikely, as many pedestrians move in social groups that are based on friendship or kinship. We test how the presence of social groups affects the egress time of individuals and crowds in a representative crowd evacuation experiment. Our results suggest that the presence of social groups increases egress times and that this is largely due to differences at two stages of evacuations. First, individuals in social groups take longer to show a movement response at the start of evacuations, and, second, they take longer to move into the vicinity of the exits once they have started to move towards them. Surprisingly, there are no discernible time differences between the movement of independent individuals and individuals in groups directly in front of the exits. We explain these results and discuss their implications. Our findings elucidate behavioural differences between independent individuals and social groups in evacuations. Such insights are crucial for the control of crowd evacuations and for planning mass events. PMID:25785603

Triarchic Model Personality Traits and Their Impact on Mock Juror Perceptions of a White-Collar Criminal Defendant.

PubMed

Rulseh, Allison; Edens, John F; Cox, Jennifer

2017-01-01

The triarchic model of psychopathy proposes that this personality disorder is composed of 3 relatively distinct constructs: meanness, disinhibition, and boldness. Although the first 2 components are widely accepted, boldness has generated considerable theoretical debate concerning its relevance-largely due to its association with various ostensibly adaptive characteristics and socially desirable behaviors (e.g., self-reported heroism). But is being bold actually perceived by others as an intrinsically adaptive, socially desirable personality trait? We investigated this question using a novel approach-a jury simulation study that manipulated the level of triarchic traits exhibited by a white-collar criminal. More specifically, 330 community members read a vignette in which the defendant's degree of boldness and disinhibition was manipulated and then provided sentence recommendations and other evaluative ratings. As hypothesized, manipulating boldness and disinhibition resulted in more negative views of the defendant, with the boldness manipulation more consistently predicting higher global psychopathy, "meanness," and "evil" ratings. Surprisingly, neither manipulation predicted sentence recommendations, although higher global psychopathy ratings did correlate with more punitive sentence recommendations. The presence of personality traits construed in some contexts as advantageous or socially desirable can be perceived as more dysfunctional and undesirable in other contexts-particularly when they cooccur with criminal behavior.

Personality and complex brain networks: The role of openness to experience in default network efficiency

PubMed Central

Kaufman, Scott Barry; Benedek, Mathias; Jung, Rex E.; Kenett, Yoed N.; Jauk, Emanuel; Neubauer, Aljoscha C.; Silvia, Paul J.

2015-01-01

Abstract The brain's default network (DN) has been a topic of considerable empirical interest. In fMRI research, DN activity is associated with spontaneous and self‐generated cognition, such as mind‐wandering, episodic memory retrieval, future thinking, mental simulation, theory of mind reasoning, and creative cognition. Despite large literatures on developmental and disease‐related influences on the DN, surprisingly little is known about the factors that impact normal variation in DN functioning. Using structural equation modeling and graph theoretical analysis of resting‐state fMRI data, we provide evidence that Openness to Experience—a normally distributed personality trait reflecting a tendency to engage in imaginative, creative, and abstract cognitive processes—underlies efficiency of information processing within the DN. Across two studies, Openness predicted the global efficiency of a functional network comprised of DN nodes and corresponding edges. In Study 2, Openness remained a robust predictor—even after controlling for intelligence, age, gender, and other personality variables—explaining 18% of the variance in DN functioning. These findings point to a biological basis of Openness to Experience, and suggest that normally distributed personality traits affect the intrinsic architecture of large‐scale brain systems. Hum Brain Mapp 37:773–779, 2016. © 2015 Wiley Periodicals, Inc. PMID:26610181

What are we protecting? Fisher behavior and the unintended consequences of spatial closures as a fishery management tool.

PubMed

Abbott, Joshua K; Haynie, Alan C

2012-04-01

Spatial closures like marine protected areas (MPAs) are prominent tools for ecosystem-based management in fisheries. However, the adaptive behavior of fishermen, the apex predator in the ecosystem, to MPAs may upset the balance of fishing impacts across species. While ecosystem-based management (EBM) emphasizes the protection of all species in the environment, the weakest stock often dominates management attention. We use data before and after the implementation of large spatial closures in a North Pacific trawl fishery to show how closures designed for red king crab protection spurred dramatic increases in Pacific halibut bycatch due to both direct displacement effects and indirect effects from adaptations in fishermen's targeting behavior. We identify aspects of the ecological and economic context of the fishery that contributed to these surprising behaviors, noting that many multispecies fisheries are likely to share these features. Our results highlight the need either to anticipate the behavioral adaptations of fishermen across multiple species in reserve design, a form of implementation error, or to design management systems that are robust to these adaptations. Failure to do so may yield patterns of fishing effort and mortality that undermine the broader objectives of multispecies management and potentially alter ecosystems in profound ways.

Optimal investment and location decisions of a firm in a flood risk area using Impulse Control Theory

NASA Astrophysics Data System (ADS)

Grames, Johanna; Grass, Dieter; Kort, Peter; Prskawetz, Alexia

2017-04-01

Flooding events can affect businesses close to rivers, lakes or coasts. This paper provides a partial equilibrium model which helps to understand the optimal location choice for a firm in flood risk areas and its investment strategies. How often, when and how much are firms willing to invest in flood risk protection measures? We apply Impulse Control Theory to solve the model analytically and develop a continuation algorithm to solve the model numerically. Firms always invest in flood defense. The investment increases the higher the flood risk and the more firms also value the future, i.e. the more sustainable they plan. Investments in production capital follow a similar path. Hence, planning in a sustainable way leads to economic growth. Sociohydrological feedbacks are crucial for the location choice of the firm, whereas different economic situations have an impact on investment strategies. If flood defense is already present, e.g. built up by the government, firms move closer to the water and invest less in flood defense, which allows firms to accrue higher expected profits. Firms with a large initial production capital surprisingly try not to keep their market advantage, but rather reduce flood risk by reducing exposed production capital.

Realized niche width of a brackish water submerged aquatic vegetation under current environmental conditions and projected influences of climate change.

PubMed

Kotta, Jonne; Möller, Tiia; Orav-Kotta, Helen; Pärnoja, Merli

2014-12-01

Little is known about how organisms might respond to multiple climate stressors and this lack of knowledge limits our ability to manage coastal ecosystems under contemporary climate change. Ecological models provide managers and decision makers with greater certainty that the systems affected by their decisions are accurately represented. In this study Boosted Regression Trees modelling was used to relate the cover of submerged aquatic vegetation to the abiotic environment in the brackish Baltic Sea. The analyses showed that the majority of the studied submerged aquatic species are most sensitive to changes in water temperature, current velocity and winter ice scour. Surprisingly, water salinity, turbidity and eutrophication have little impact on the distributional pattern of the studied biota. Both small and large scale environmental variability contributes to the variability of submerged aquatic vegetation. When modelling species distribution under the projected influences of climate change, all of the studied submerged aquatic species appear to be very resilient to a broad range of environmental perturbation and biomass gains are expected when seawater temperature increases. This is mainly because vegetation develops faster in spring and has a longer growing season under the projected climate change scenario. Copyright © 2014 Elsevier Ltd. All rights reserved.

Stochastic Modulations of the Pace and Patterns of Ageing: Impacts on Quasi-Stochastic Distributions of Multiple Geriatric Pathologies

PubMed Central

Martin, George M.

2011-01-01

All phenotypes result from interactions between Nature, Nurture and Chance. The constitutional genome is clearly the dominant factor in explaining the striking differences in the pace and patterns of ageing among species. We are now in a position to reveal salient features underlying these differential modulations, which are likely to be dominated by regulatory domains. By contrast, I shall argue that stochastic events are the major players underlying the surprisingly large intra-specific variations in lifespan and healthspan. I shall review well established as well as more speculative categories of chance events – somatic mutations, protein synthesis error catastrophe and variegations of gene expression (epigenetic drift), with special emphasis upon the latter. I shall argue that stochastic drifts in variegated gene expression are the major contributors to intra-specific differences in the pace and patterns of ageing within members of the same species. They may be responsible for the quasi-stochastic distributions of major types of geriatric pathologies, including the “big three” of Alzheimer's disease, atherosclerosis and, via the induction of hyperplasis, cancer. They may be responsible for altered stoichiometries of heteromultimeric mitochondrial complexes, potentially leading to such disorders as sarcopenia, nonischemic cardiomyopathy and Parkinson's disease. PMID:21963385

A comprehensive comparison of tools for differential ChIP-seq analysis

PubMed Central

Steinhauser, Sebastian; Kurzawa, Nils; Eils, Roland

2016-01-01

ChIP-seq has become a widely adopted genomic assay in recent years to determine binding sites for transcription factors or enrichments for specific histone modifications. Beside detection of enriched or bound regions, an important question is to determine differences between conditions. While this is a common analysis for gene expression, for which a large number of computational approaches have been validated, the same question for ChIP-seq is particularly challenging owing to the complexity of ChIP-seq data in terms of noisiness and variability. Many different tools have been developed and published in recent years. However, a comprehensive comparison and review of these tools is still missing. Here, we have reviewed 14 tools, which have been developed to determine differential enrichment between two conditions. They differ in their algorithmic setups, and also in the range of applicability. Hence, we have benchmarked these tools on real data sets for transcription factors and histone modifications, as well as on simulated data sets to quantitatively evaluate their performance. Overall, there is a great variety in the type of signal detected by these tools with a surprisingly low level of agreement. Depending on the type of analysis performed, the choice of method will crucially impact the outcome. PMID:26764273

Flash floods in the Tatra Mountain streams: frequency and triggers.

PubMed

Ballesteros-Cánovas, J A; Czajka, B; Janecka, K; Lempa, M; Kaczka, R J; Stoffel, M

2015-04-01

Flash floods represent a frequently recurring natural phenomenon in the Tatra Mountains. On the northern slopes of the mountain chain, located in Poland, ongoing and expected future changes in climate are thought to further increase the adverse impacts of flash floods. Despite the repeat occurrence of major floods in the densely populated foothills of the Polish Tatras, the headwaters have been characterized by a surprising lack of data, such that any analysis of process variability or hydrometeorological triggers has been largely hampered so far. In this study, dendrogeomorphic techniques have been employed in four poorly-gauged torrential streams of the northern slope of the Tatra Mountains to reconstruct temporal and spatial patterns of past events. Using more than 1100 increment cores of trees injured by past flash floods, we reconstruct 47 events covering the last 148 years and discuss synoptic situations leading to the triggering of flash floods with the existing meteorological and flow gauge data. Tree-ring analyses have allowed highlighting the seasonality of events, providing new insights about potential hydrometeorological triggers as well as a differentiating flash flood activity between catchments. Results of this study could be useful to design future strategies to deal with flash flood risks at the foothills of the Polish Tatras and in the Vistula River catchment. Copyright © 2014. Published by Elsevier B.V.

EsrE-A yigP Locus-Encoded Transcript-Is a 3′ UTR sRNA Involved in the Respiratory Chain of E. coli

PubMed Central

Xia, Hui; Yang, Xichen; Tang, Qiongwei; Ye, Jiang; Wu, Haizhen; Zhang, Huizhan

2017-01-01

The yigP locus is widely conserved among γ-proteobacteria. Mutation of the yigP locus impacts aerobic growth of Gram-negative bacteria. However, the underlying mechanism of how the yigP locus influences aerobic growth remains largely unknown. Here, we demonstrated that the yigP locus in Escherichia coli encodes two transcripts; the mRNA of ubiquinone biosynthesis protein, UbiJ, and the 3′ untranslated region small regulatory RNA (sRNA), EsrE. EsrE is an independent transcript that is transcribed using an internal promoter of the yigP locus. Surprisingly, we found that both the EsrE sRNA and UbiJ protein were required for Q8 biosynthesis, and were sufficient to rescue the growth defect ascribed to deletion of the yigP locus. Moreover, our data showed that EsrE targeted multiple mRNAs involved in several cellular processes including murein biosynthesis and the tricarboxylic acid cycle. Among these targets, sdhD mRNA that encodes one subunit of succinate dehydrogenase (SDH), was significantly activated. Our findings provided an insight into the important function of EsrE in bacterial adaptation to various environments, as well as coordinating different aspects of bacterial physiology. PMID:28900423

Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia

PubMed Central

Xu, Zhiliang; Zartman, Jeremiah J.; Alber, Mark

2017-01-01

Mitotic rounding during cell division is critical for preventing daughter cells from inheriting an abnormal number of chromosomes, a condition that occurs frequently in cancer cells. Cells must significantly expand their apical area and transition from a polygonal to circular apical shape to achieve robust mitotic rounding in epithelial tissues, which is where most cancers initiate. However, how cells mechanically regulate robust mitotic rounding within packed tissues is unknown. Here, we analyze mitotic rounding using a newly developed multi-scale subcellular element computational model that is calibrated using experimental data. Novel biologically relevant features of the model include separate representations of the sub-cellular components including the apical membrane and cytoplasm of the cell at the tissue scale level as well as detailed description of cell properties during mitotic rounding. Regression analysis of predictive model simulation results reveals the relative contributions of osmotic pressure, cell-cell adhesion and cortical stiffness to mitotic rounding. Mitotic area expansion is largely driven by regulation of cytoplasmic pressure. Surprisingly, mitotic shape roundness within physiological ranges is most sensitive to variation in cell-cell adhesivity and stiffness. An understanding of how perturbed mechanical properties impact mitotic rounding has important potential implications on, amongst others, how tumors progressively become more genetically unstable due to increased chromosomal aneuploidy and more aggressive. PMID:28531187

Infectious diseases of marine molluscs and host responses as revealed by genomic tools

PubMed Central

Ford, Susan E.

2016-01-01

More and more infectious diseases affect marine molluscs. Some diseases have impacted commercial species including MSX and Dermo of the eastern oyster, QPX of hard clams, withering syndrome of abalone and ostreid herpesvirus 1 (OsHV-1) infections of many molluscs. Although the exact transmission mechanisms are not well understood, human activities and associated environmental changes often correlate with increased disease prevalence. For instance, hatcheries and large-scale aquaculture create high host densities, which, along with increasing ocean temperature, might have contributed to OsHV-1 epizootics in scallops and oysters. A key to understanding linkages between the environment and disease is to understand how the environment affects the host immune system. Although we might be tempted to downplay the role of immunity in invertebrates, recent advances in genomics have provided insights into host and parasite genomes and revealed surprisingly sophisticated innate immune systems in molluscs. All major innate immune pathways are found in molluscs with many immune receptors, regulators and effectors expanded. The expanded gene families provide great diversity and complexity in innate immune response, which may be key to mollusc's defence against diverse pathogens in the absence of adaptive immunity. Further advances in host and parasite genomics should improve our understanding of genetic variation in parasite virulence and host disease resistance. PMID:26880838

Rapid decay of tree-community composition in Amazonian forest fragments

PubMed Central

Laurance, William F.; Nascimento, Henrique E. M.; Laurance, Susan G.; Andrade, Ana; Ribeiro, José E. L. S.; Giraldo, Juan Pablo; Lovejoy, Thomas E.; Condit, Richard; Chave, Jerome; Harms, Kyle E.; D'Angelo, Sammya

2006-01-01

Forest fragmentation is considered a greater threat to vertebrates than to tree communities because individual trees are typically long-lived and require only small areas for survival. Here we show that forest fragmentation provokes surprisingly rapid and profound alterations in Amazonian tree-community composition. Results were derived from a 22-year study of exceptionally diverse tree communities in 40 1-ha plots in fragmented and intact forests, which were sampled repeatedly before and after fragment isolation. Within these plots, trajectories of change in abundance were assessed for 267 genera and 1,162 tree species. Abrupt shifts in floristic composition were driven by sharply accelerated tree mortality and recruitment within ≈100 m of fragment margins, causing rapid species turnover and population declines or local extinctions of many large-seeded, slow-growing, and old-growth taxa; a striking increase in a smaller set of disturbance-adapted and abiotically dispersed species; and significant shifts in tree size distributions. Even among old-growth trees, species composition in fragments is being restructured substantially, with subcanopy species that rely on animal seed-dispersers and have obligate outbreeding being the most strongly disadvantaged. These diverse changes in tree communities are likely to have wide-ranging impacts on forest architecture, canopy-gap dynamics, plant–animal interactions, and forest carbon storage. PMID:17148598

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoffman, M.

Six months after Saddam Hussein's torching of more than 700 Kuwaiti oil wells, health officials, meteorologists, and environmental experts convened during mid-August in Cambridge, Massachusetts, to assess the impact of the fires. The soot cloud produced by the fires hasn't produced a nuclear winter, nor are the carbon dioxide and other gases released going to have an appreciable effect on global warming, although regional weather changes are possible. So far adverse health effects from the heavy pall of pollution caused by the fires have been surprisingly mild. This isn't to say that premature deaths will not occur, but many scientistsmore » had feared much worse. Nevertheless, all researchers concede that the data for this particular conclusion are still preliminary, and they expressed concerns that health problems may worsen in the coming months. Most of the health effects are expected in a region blanketed by a plume of smoke 800 to 1,000 kilometers long. The average concentrations of the primary pollutants it contains, carbon-based particles and sulfur dioxide, are similar to those in any large urban center. Still, the oil fires increase the pollution burden on Kuwait, which already had a problem with particulates in the air, and some epidemiologists expect that the extra pollutants will take their toll.« less

Human activities change marine ecosystems by altering predation risk.

PubMed

Madin, Elizabeth M P; Dill, Lawrence M; Ridlon, April D; Heithaus, Michael R; Warner, Robert R

2016-01-01

In ocean ecosystems, many of the changes in predation risk - both increases and decreases - are human-induced. These changes are occurring at scales ranging from global to local and across variable temporal scales. Indirect, risk-based effects of human activity are known to be important in structuring some terrestrial ecosystems, but these impacts have largely been neglected in oceans. Here, we synthesize existing literature and data to explore multiple lines of evidence that collectively suggest diverse human activities are changing marine ecosystems, including carbon storage capacity, in myriad ways by altering predation risk. We provide novel, compelling evidence that at least one key human activity, overfishing, can lead to distinct, cascading risk effects in natural ecosystems whose magnitude exceeds that of presumed lethal effects and may account for previously unexplained findings. We further discuss the conservation implications of human-caused indirect risk effects. Finally, we provide a predictive framework for when human alterations of risk in oceans should lead to cascading effects and outline a prospectus for future research. Given the speed and extent with which human activities are altering marine risk landscapes, it is crucial that conservation and management policy considers the indirect effects of these activities in order to increase the likelihood of success and avoid unfortunate surprises. © 2015 John Wiley & Sons Ltd.

The distribution of gas and ions in the inner coma of 67P/Churyumov-Gerasimenko between 3 AU before and after its perihelion

NASA Astrophysics Data System (ADS)

Bodewits, Dennis; Lara, Luisa; La Forgia, Fiorangela; A'Hearn, Michael F.; Knollenberg, Jörg; Lazzarin, Monica; Li, Zhong-Yi; Osiris Team

2016-10-01

Rosetta explored a regime not accessible before: the inner coma of a low-activity comet at a large range of heliocentric distances. The Wide Angle Camera (WAC) of the OSIRIS instrument on board the Rosetta spacecraft is equipped with several narrowband filters that are centered on the emission lines and bands of various molecules and ions. These filters center on fragment species that are relatively bright and that have been used for numerous comet studies from the ground (e.g. A'Hearn et al. 1995). Surprisingly, we found that outside 2 AU pre-perihelion, the emission in the filters was dominated by emission from dissociative electron impact excitation (Bodewits et al. 2016). Closer to perihelion, higher gas densities reduced electron temperatures in the inner coma and photo-processes drove much if not most of the emission from the comet. Our observations allowed us to study changes in the physical environment of the inner coma, and Rosetta's excursions as far as 1000 km from the surface allowed us to study different regions of the coma.In this contribution, we will summarize the results of our OSIRIS observations from approximately 3 AU before to 3 AU after perihelion.

Reexamining the role of the (n ,γ f ) process in the low-energy fission of 235U and 239Pu

NASA Astrophysics Data System (ADS)

Lynn, J. E.; Talou, P.; Bouland, O.

2018-06-01

The (n ,γ f ) process is reviewed in light of modern nuclear reaction calculations in both slow and fast neutron-induced fission reactions on 235U and 239Pu. Observed fluctuations of the average prompt fission neutron multiplicity and average total γ -ray energy below 100-eV incident neutron energy are interpreted in this framework. The surprisingly large contribution of the M 1 transitions to the prefission γ -ray spectrum of 239Pu is explained by the dominant fission probabilities of 0+ and 2+ transition states, which can only be accessed from compound nucleus states formed by the interaction of s -wave neutrons with the target nucleus in its ground state, and decaying through M 1 transitions. The impact of an additional low-lying M 1 scissors mode in the photon strength function is analyzed. We review experimental evidence for fission fragment mass and kinetic-energy fluctuations in the resonance region and their importance in the interpretation of experimental data on prompt neutron data in this region. Finally, calculations are extended to the fast energy range where (n ,γ f ) corrections can account for up to 3% of the total fission cross section and about 20% of the capture cross section.

Hidden Oceans? Unraveling the Structure of Hydrous Defects in the Earth's Deep Interior.

PubMed

Grüninger, Helen; Armstrong, Katherine; Greim, Dominik; Boffa-Ballaran, Tiziana; Frost, Daniel J; Senker, Jürgen

2017-08-02

High-pressure silicates making up the main proportion of the earth's interior can incorporate a significant amount of water in the form of OH defects. Generally, they are charge balanced by removing low-valent cations such as Mg 2+ . By combining high-resolution multidimensional single- and double-quantum 1 H solid-state NMR spectroscopy with density functional theory calculations, we show that, for ringwoodite (γ-Mg 2 SiO 4 ), additionally, Si 4+ vacancies are formed, even at a water content as low as 0.1 wt %. They are charge balanced by either four protons or one Mg 2+ and two protons. Surprisingly, also a significant proportion of coupled Mg and Si vacancies are present. Furthermore, all defect types feature a pronounced orientational disorder of the OH groups, which results in a significant range of OH···O bond distributions. As such, we are able to present unique insight into the defect chemistry of ringwoodite's spinel structure, which not only accounts for a potentially large fraction of the earth's entire water budget, but will also control transport properties in the mantle. We expect that our results will even impact other hydrous spinel-type materials, helping to understand properties such as ion conduction and heterogeneous catalysis.

Evidence of multimicrometric coherent γ' precipitates in a hot-forged γ-γ' nickel-based superalloy.

PubMed

Charpagne, M-A; Vennéguès, P; Billot, T; Franchet, J-M; Bozzolo, N

2016-07-01

This paper demonstrates the existence of large γ' precipitates (several micrometres in diameter) that are coherent with their surrounding matrix grain in a commercial γ-γ' nickel-based superalloy. The use of combined energy dispersive X-ray spectrometry and electron backscattered diffraction (EBSD) analyses allowed for revealing that surprising feature, which was then confirmed by transmission electron microscopy (TEM). Coherency for such large second-phase particles is supported by a very low crystal lattice misfit between the two phases, which was confirmed thanks to X-ray diffractograms and TEM selected area electron diffraction patterns. Dynamic recrystallization of polycrystalline γ-γ' nickel-based superalloys has been extensively studied in terms of mechanisms and kinetics. As in many materials with low stacking fault energy, under forging conditions, the main softening mechanism is discontinuous dynamic recrystallization. This mechanism occurs with preferential nucleation on the grain boundaries of the deformed matrix. The latter is then being consumed by the growth of the newly formed grains of low energy and by nucleation that keeps generating new grains. In the case of sub-solvus forging, large γ' particles usually pin the migrating boundaries and thus limit grain growth to a size which is determined by the distribution of second-phase particles, in good agreement with the Smith-Zener model. Under particular circumstances, the driving force associated with the difference in stored energy between the growing grains and the matrix can be large enough that the pinning forces can be overcome, and some grains can then reach much larger grain sizes. In the latter exceptional case, some intragranular primary γ' particles can be observed, although they are almost exclusively located on grain boundaries and triple junctions otherwise. In both cases, primary precipitates have no special orientation relationship with the surrounding matrix grain(s). This paper demonstrates the existence of high fractions of large γ' precipitate (several micrometres in diameter) that are coherent with their surrounding matrix grain, in a commercial γ-γ' nickel-based superalloy. Such a configuration is very surprising, because there is apparently no reason for the coherency of such particles. © 2016 The Authors Journal of Microscopy © 2016 Royal Microscopical Society.

Numbers and space: associations and dissociations.

PubMed

Nathan, Merav Ben; Shaki, Samuel; Salti, Moti; Algom, Daniel

2009-06-01

A cornerstone of contemporary research in numerical cognition is the surprising link found between numbers and space. In particular, people react faster and more accurately to small numbers with a left-hand key and to large numbers with a right-hand key. Because this contingency is found in a variety of tasks, it has been taken to support the automatic activation of magnitude as well as the notion of a mental number line arranged from left to right. The present study challenges the presence of a link between left-right location, on the one hand, and small-large number, on the other hand. We show that a link exists between space and relative magnitude, a relationship that might or might not be unique to numbers.

The Sivers effect and the Single Spin Asymmetry A_N in p(transv. pol.) p --> h X processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anselmino, Mauro; Boglione, Mariaelena; D'Alesio, Umberto

2013-09-01

The single spin asymmetry A_N, for large P_T single inclusive particle production in p(transv. pol.) p collisions, is considered within a generalised parton model and a transverse momentum dependent factorisation scheme. The focus is on the Sivers effect and the study of its potential contribution to A_N, based on a careful analysis of the Sivers functions extracted from azimuthal asymmetries in semi-inclusive deep inelastic scattering processes. It is found that such Sivers functions could explain most features of the A_N data, including some recent STAR results which show the persistence of a non zero A_N up to surprisingly large P_Tmore » values.« less

Sex and gender differences in pain and analgesia.

PubMed

Mogil, Jeffrey S; Bailey, Andrea L

2010-01-01

It is a clinical reality that women make up the large majority of chronic pain patients, and there is now consensus from laboratory experiments that when differences are seen, women are more sensitive to pain than men. Research in this field has now begun to concentrate on finding explanations for this sex difference. Although sex differences in sociocultural, psychological, and experiential factors likely play important roles, evidence largely from animal studies has revealed surprisingly robust and often qualitative sex differences at low levels of the neuraxis. Although not yet able to affect clinical practice, the continued study of sex differences in pain may have important implications for the development of new analgesic strategies. Copyright © 2010 Elsevier B.V. All rights reserved.

Yielding and flow of colloidal glasses.

PubMed

Petekidis, Georgios; Vlassopoulos, Dimitris; Pusey, Peter N

2003-01-01

We investigate the yielding and flow of hard-sphere colloidal glasses by combining rheological measurements with the technique of light scattering echo. The polymethylmethacrylate particles used are sufficiently polydisperse that crystallization is suppressed. Creep and recovery measurements show that the glasses can tolerate surprisingly large strains, up to at least 15%, before yielding irreversibly. We attribute this behaviour to 'cage elasticity', the ability of a particle and its cage of neighbours to retain their identity under quite large distortion. Results from light scattering echo, which measures the extent of irreversible particle rearrangement under oscillatory shear, support the notion of cage elasticity. In the lower concentration glasses we find that particle trajectories are partly reversible under strains which significantly exceed the yield strain.

Maternal Depression and Parenting in Early Childhood: Contextual Influence of Marital Quality and Social Support in Two Samples

PubMed Central

Taraban, Lindsay; Shaw, Daniel S.; Leve, Leslie D.; Wilson, Melvin N.; Dishion, Thomas J.; Natsuaki, Misaki N.; Neiderhiser, Jenae M.; Reiss, David

2016-01-01

Marital quality and social support satisfaction were tested as moderators of the association between maternal depressive symptoms and parenting during early childhood (18-36 months) among two large, divergent, longitudinal samples (n = 526; n = 570). Unexpectedly, in both samples the association between maternal depressive symptoms and reduced parenting quality was strongest in the context of high marital quality and high social support, and largely non-significant in the context of low marital quality and low social support. Possible explanations for these surprising findings are discussed. Results point to the importance of accounting for factors in the broader family context in predicting the association between depressive symptoms and maternal parenting. PMID:28230401

Gene-expression signatures of Atlantic salmon's plastic life cycle.

PubMed

Aubin-Horth, Nadia; Letcher, Benjamin H; Hofmann, Hans A

2009-09-15

How genomic expression differs as a function of life history variation is largely unknown. Atlantic salmon exhibits extreme alternative life histories. We defined the gene-expression signatures of wild-caught salmon at two different life stages by comparing the brain expression profiles of mature sneaker males and immature males, and early migrants and late migrants. In addition to life-stage-specific signatures, we discovered a surprisingly large gene set that was differentially regulated-at similar magnitudes, yet in opposite direction-in both life history transitions. We suggest that this co-variation is not a consequence of many independent cellular and molecular switches in the same direction but rather represents the molecular equivalent of a physiological shift orchestrated by one or very few master regulators.

The postcollapse core of M15 imaged with the HST planetary camera

NASA Technical Reports Server (NTRS)

Lauer, Tod R.; Holtzman, Jon A.; Faber, S. M.; Baum, William A.; Currie, Douglas G.; Ewald, S. P.; Groth, Edward J.; Hester, J. Jeff; Kelsall, T.

1991-01-01

It is shown here that, despite the severe spherical aberration present in the HST, the Wide Field/Planetary Camera (WFPC) images still present useful high-resolution information on M15, the classic candidate for a cluster with a collapsed core. The stars in M15 have been resolved down to the main-sequence turnoff and have been subtracted from the images. The remaining faint, unresolved stars form a diffuse background with a surprisingly large core with r(c) = 0.13 pc. The existence of a large core interior to the power-law cusp may imply that M15 has evolved well past maximum core collapse and may rule out the presence of a massive central black hole as well.

Cannibalism in Tyrannosaurus rex.

PubMed

Longrich, Nicholas R; Horner, John R; Erickson, Gregory M; Currie, Philip J

2010-10-15

Tyrannosaurus rex was one of the largest terrestrial carnivores of all time, and consequently its ecology and diet have been the focus of much discussion. However, there is little direct evidence of diet or feeding habits in this species. Examination of museum collections has revealed four specimens of Tyrannosaurus rex that bear tooth marks made by large, carnivorous dinosaurs. Because Tyrannosaurus is the only large carnivore known from the Late Maastrichtian of western North America, we infer that Tyrannosaurus made these tooth marks. The marks are interpreted as feeding traces and these fossils therefore record instances of cannibalism. Given that this behavior has a low preservation potential, cannibalism seems to have been a surprisingly common behavior in Tyrannosaurus, and this behavior may have been relatively common in carnivorous dinosaurs.

Low redshift Lyman alpha absorption lines and the dark matter halos of disk galaxies

NASA Technical Reports Server (NTRS)

Maloney, Philip

1993-01-01

Recent observations using the Hubble Space Telescope of the z = 0.156 QSO 3C 273 have discovered a surprisingly large number of Ly-alpha absorption lines. In particular, Morris et al. found 9 certain and 7 possible Ly-alpha lines with equivalent widths above 25 mA. This is much larger (by a factor of 5-10) than the number expected from extrapolation of the high-redshift behavior of the Ly-alpha forest. Within the context of pressure-confined models for the Ly-alpha clouds, this behavior can be understood if the ionizing background declines sharply between z is approximately 2 and z is approximately 0. However, this requires that the ionizing photon flux drop as rapidly as the QSO volume emissivity; moreover, the absorbers must have a space density n(sub O) is approximately 2.6(N/10)h/((D/100 kpc)(sup 2)) Mpc(sup -3) where D is the present-day diameter of the absorbers. It is somewhat surprising that such necessarily fragile objects could have survived in such numbers to the present day. It is shown that it is plausible that the atomic hydrogen extents of spiral and irregular galaxies are large enough to produce the observed number of Ly-alpha absorption lines toward 3C 273, and that the neutral column densities and doppler b-values expected under these conditions fall in the range found by Morris et al. (1991).

Some Surprising Introductory Physics Facts and Numbers

NASA Astrophysics Data System (ADS)

Mallmann, A. James

2016-04-01

In the entertainment world, people usually like, and find memorable, novels, short stories, and movies with surprise endings. This suggests that classroom teachers might want to present to their students examples of surprising facts associated with principles of physics. Possible benefits of finding surprising facts about principles of physics are opportunities to expand beyond traditional presentations—and, in some cases, to achieve a deeper and broader understanding of those principles. I believe, moreover, that some of the facts presented here may inspire physics teachers to produce some challenge problems for students.

Phase transition of Surprise optimization in community detection

NASA Astrophysics Data System (ADS)

Xiang, Ju; Tang, Yan-Ni; Gao, Yuan-Yuan; Liu, Lang; Hao, Yi; Li, Jian-Ming; Zhang, Yan; Chen, Shi

2018-02-01

Community detection is one of important issues in the research of complex networks. In literatures, many methods have been proposed to detect community structures in the networks, while they also have the scope of application themselves. In this paper, we investigate an important measure for community detection, Surprise (Aldecoa and Marín, Sci. Rep. 3 (2013) 1060), by focusing on the critical points in the merging and splitting of communities. We firstly analyze the critical behavior of Surprise and give the phase diagrams in community-partition transition. The results show that the critical number of communities for Surprise has a super-exponential increase with the increase of the link-density difference, while it is close to that of Modularity for small difference between inter- and intra-community link densities. By directly optimizing Surprise, we experimentally test the results on various networks, following a series of comparisons with other classical methods, and further find that the heterogeneity of networks could quicken the splitting of communities. On the whole, the results show that Surprise tends to split communities due to various reasons such as the heterogeneity in link density, degree and community size, and it thus exhibits higher resolution than other methods, e.g., Modularity, in community detection. Finally, we provide several approaches for enhancing Surprise.

Conversations about electricity and the future: Findings of an international seminar and lessons from a year of surprises

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rossin, A.D.; Fowler, K.

In January 1990 thirty-two experts from twelve countries convened for a five-day working Seminar on the Berkeley Campus of the University of California to discuss electricity supply and demand. The participants brought with them deep and diverse backgrounds in energy issues. A major concern of the First 1990 Group on Electricity was the potential impact of electricity shortages on the environment, just at a time of growing awareness of environmental deterioration. These concerns extend from local problems to nations, regions and global impacts. Indeed, because of the importance of electricity in our lives, potential electric power shortages already foreseeable inmore » this decade could overwhelm public concern for the environment, unless critical, long-leadtime measures are taken very soon. The First 1990 Group on Electricity's Findings and Conclusions, the thinking that led to them, and the impact of events in the intervening year form the content of this book.« less

The Larger the Viscosity, the Higher the Bounce

NASA Astrophysics Data System (ADS)

Stern, Menachem; Klein Schaarsberg, Martin; Peters, Ivo; Dodge, Kevin; Zhang, Wendy; Jaeger, Heinrich

A low-viscosity liquid drop can bounce upon impact onto a solid. A high-viscosity drop typically just flattens, i.e., it splats. Surprisingly, our experiments with a droplet made of densely packed glass beads in silicone oil display the opposite behavior: the low-viscosity oil suspension drop splats. The high-viscosity oil suspension bounces. Increasing solvent viscosity increases the rebound energy. To gain insight into the underlying mechanism, we model the suspension as densely packed elastic spheres experiencing viscous lubrication drag between neighbors. The model reproduces the observed trends. Plots of elastic compression and drag experienced by the particles show that rebounds are made possible by (1) a fraction of the impact energy being stored during initial contact via elastic compression, (2) a rapid broadening of local lubrication drag interactions at the initial impact site into a spatially uniform upward force throughout the drop. Including finite wall drag due to the presence of ambient air into the numerical model diminishes and eventually cuts off the rebound.

Overload-based cascades on multiplex networks and effects of inter-similarity

PubMed Central

Zhou, Dong

2017-01-01

Although cascading failures caused by overload on interdependent/interconnected networks have been studied in the recent years, the effect of overlapping links (inter-similarity) on robustness to such cascades in coupled networks is not well understood. This is an important issue since shared links exist in many real-world coupled networks. In this paper, we propose a new model for load-based cascading failures in multiplex networks. We leverage it to compare different network structures, coupling schemes, and overload rules. More importantly, we systematically investigate the impact of inter-similarity on the robustness of the whole system under an initial intentional attack. Surprisingly, we find that inter-similarity can have a negative impact on robustness to overload cascades. To the best of our knowledge, we are the first to report the competition between the positive and the negative impacts of overlapping links on the robustness of coupled networks. These results provide useful suggestions for designing robust coupled traffic systems. PMID:29252988

Novel quantum phase transition from bounded to extensive entanglement

PubMed Central

Zhang, Zhao; Ahmadain, Amr

2017-01-01

The nature of entanglement in many-body systems is a focus of intense research with the observation that entanglement holds interesting information about quantum correlations in large systems and their relation to phase transitions. In particular, it is well known that although generic, many-body states have large, extensive entropy, ground states of reasonable local Hamiltonians carry much smaller entropy, often associated with the boundary length through the so-called area law. Here we introduce a continuous family of frustration-free Hamiltonians with exactly solvable ground states and uncover a remarkable quantum phase transition whereby the entanglement scaling changes from area law into extensively large entropy. This transition shows that entanglement in many-body systems may be enhanced under special circumstances with a potential for generating “useful” entanglement for the purpose of quantum computing and that the full implications of locality and its restrictions on possible ground states may hold further surprises. PMID:28461464

Novel quantum phase transition from bounded to extensive entanglement.

PubMed

Zhang, Zhao; Ahmadain, Amr; Klich, Israel

2017-05-16

The nature of entanglement in many-body systems is a focus of intense research with the observation that entanglement holds interesting information about quantum correlations in large systems and their relation to phase transitions. In particular, it is well known that although generic, many-body states have large, extensive entropy, ground states of reasonable local Hamiltonians carry much smaller entropy, often associated with the boundary length through the so-called area law. Here we introduce a continuous family of frustration-free Hamiltonians with exactly solvable ground states and uncover a remarkable quantum phase transition whereby the entanglement scaling changes from area law into extensively large entropy. This transition shows that entanglement in many-body systems may be enhanced under special circumstances with a potential for generating "useful" entanglement for the purpose of quantum computing and that the full implications of locality and its restrictions on possible ground states may hold further surprises.

Breakdown of Universality for Unequal-Mass Fermi Gases with Infinite Scattering Length

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blume, D.; Daily, K. M.

We treat small trapped unequal-mass two-component Fermi gases at unitarity within a nonperturbative microscopic framework and investigate the system properties as functions of the mass ratio {kappa}, and the numbers N{sub 1} and N{sub 2} of heavy and light fermions. While equal-mass Fermi gases with infinitely large interspecies s-wave scattering length a{sub s} are universal, we find that unequal-mass Fermi gases are, for sufficiently large {kappa} and in the regime where Efimov physics is absent, not universal. In particular, the (N{sub 1},N{sub 2})=(2,1) and (3, 1) systems exhibit three-body and four-body resonances at {kappa}=12.314(2) and 10.4(2), respectively, as well asmore » surprisingly large finite-range effects. These findings have profound implications for ongoing experimental efforts and quantum simulation proposals that utilize unequal-mass atomic Fermi gases.« less

The former Iron Curtain still drives biodiversity-profit trade-offs in German agriculture.

PubMed

Batáry, Péter; Gallé, Róbert; Riesch, Friederike; Fischer, Christina; Dormann, Carsten F; Mußhoff, Oliver; Császár, Péter; Fusaro, Silvia; Gayer, Christoph; Happe, Anne-Kathrin; Kurucz, Kornélia; Molnár, Dorottya; Rösch, Verena; Wietzke, Alexander; Tscharntke, Teja

2017-09-01

Agricultural intensification drives biodiversity loss and shapes farmers' profit, but the role of legacy effects and detailed quantification of ecological-economic trade-offs are largely unknown. In Europe during the 1950s, the Eastern communist bloc switched to large-scale farming by forced collectivization of small farms, while the West kept small-scale private farming. Here we show that large-scale agriculture in East Germany reduced biodiversity, which has been maintained in West Germany due to >70% longer field edges than those in the East. In contrast, profit per farmland area in the East was 50% higher than that in the West, despite similar yield levels. In both regions, switching from conventional to organic farming increased biodiversity and halved yield levels, but doubled farmers' profits. In conclusion, European Union policy should acknowledge the surprisingly high biodiversity benefits of small-scale agriculture, which are on a par with conversion to organic agriculture.

Heritability maps of human face morphology through large-scale automated three-dimensional phenotyping

NASA Astrophysics Data System (ADS)

Tsagkrasoulis, Dimosthenis; Hysi, Pirro; Spector, Tim; Montana, Giovanni

2017-04-01

The human face is a complex trait under strong genetic control, as evidenced by the striking visual similarity between twins. Nevertheless, heritability estimates of facial traits have often been surprisingly low or difficult to replicate. Furthermore, the construction of facial phenotypes that correspond to naturally perceived facial features remains largely a mystery. We present here a large-scale heritability study of face geometry that aims to address these issues. High-resolution, three-dimensional facial models have been acquired on a cohort of 952 twins recruited from the TwinsUK registry, and processed through a novel landmarking workflow, GESSA (Geodesic Ensemble Surface Sampling Algorithm). The algorithm places thousands of landmarks throughout the facial surface and automatically establishes point-wise correspondence across faces. These landmarks enabled us to intuitively characterize facial geometry at a fine level of detail through curvature measurements, yielding accurate heritability maps of the human face (www.heritabilitymaps.info).

Conjunction Assessment Late-Notice High-Interest Event Investigation: Space Weather Aspects

NASA Technical Reports Server (NTRS)

Pachura, D.; Hejduk, M. D.

2016-01-01

Late-notice events usually driven by large changes in primary (protected) object or secondary object state. Main parameter to represent size of state change is component position difference divided by associated standard deviation (epsilon divided by sigma) from covariance. Investigation determined actual frequency of large state changes, in both individual and combined states. Compared them to theoretically expected frequencies. Found that large changes ( (epsilon divided by sigma) is greater than 3) in individual object states occur much more frequently than theory dictates. Effect is less pronounced in radial components and in events with probability of collision (Pc) greater than 1 (sup -5) (1e-5). Found combined state matched much closer to theoretical expectation, especially for radial and cross-track. In-track is expected to be the most vulnerable to modeling errors, so not surprising that non-compliance largest in this component.

Interferon γ limits the effectiveness of melanoma peptide vaccines.

PubMed

Cho, Hyun-Il; Lee, Young-Ran; Celis, Esteban

2011-01-06

The development of effective therapeutic vaccines to generate tumor-reactive cytotoxic T lymphocytes (CTLs) continues to be a top research priority. However, in spite of some promising results, there are no clear examples of vaccines that eradicate established tumors. Most vaccines are ineffective because they generate low numbers of CTLs and because numerous immunosuppressive factors abound in tumor-bearing hosts. We designed a peptide vaccine that produces large numbers of tumor-reactive CTLs in a mouse model of melanoma. Surprisingly, CTL tumor recognition and antitumor effects decreased in the presence of interferon γ (IFNγ), a cytokine that can provide therapeutic benefit. Tumors exposed to IFNγ evade CTLs by inducing large amounts of noncognate major histocompatibility complex class I molecules, which limit T-cell activation and effector function. Our results demonstrate that peptide vaccines can eradicate large, established tumors in circumstances under which the inhibitory activities of IFNγ are curtailed.

The Extracellular δ-Domain is Essential for the Formation of CD81 Tetraspanin Webs

PubMed Central

Homsi, Yahya; Schloetel, Jan-Gero; Scheffer, Konstanze D.; Schmidt, Thomas H.; Destainville, Nicolas; Florin, Luise; Lang, Thorsten

2014-01-01

CD81 is a ubiquitously expressed member of the tetraspanin family. It forms large molecular platforms, so-called tetraspanin webs that play physiological roles in a variety of cellular functions and are involved in viral and parasite infections. We have investigated which part of the CD81 molecule is required for the formation of domains in the cell membranes of T-cells and hepatocytes. Surprisingly, we find that large CD81 platforms assemble via the short extracellular δ-domain, independent from a strong primary partner binding and from weak interactions mediated by palmitoylation. The δ-domain is also essential for the platforms to function during viral entry. We propose that, instead of stable binary interactions, CD81 interactions via the small δ-domain, possibly involving a dimerization step, play the key role in organizing CD81 into large tetraspanin webs and controlling its function. PMID:24988345

The biotech equipment and supplies sector in Europe-is it European?

PubMed

Reiss, Thomas; Woerner, Stefan

2002-09-11

Socio-economic research on biotechnology is dealing mainly with the sectors of biopharmaceuticals, agro-food or environmental technologies. In contrast, the equipment and supplies sector seems to be largely ignored. This is surprising because this sector provides important input in terms of technology and material for the development of biotechnology in general. Our comparative analysis of the sector in eight countries indicates that there exists no specific science base for the sector and that it is largely neglected by public research funding. Commercial activities are concentrated in countries with a large general science base in biotechnology and strong multinational pharmaceutical or chemical companies. There is a rather broad diversity in the way the sector has developed in the eight countries. Our data support the notion that national peculiarities seem dominant for explaining this picture. We anticipate growing business opportunities for European firms to step into large markets of equipment and supplies for functional genomics and protein analyses where Europe maintains a strong science base.

Dissociable effects of surprise and model update in parietal and anterior cingulate cortex

PubMed Central

O’Reilly, Jill X.; Schüffelgen, Urs; Cuell, Steven F.; Behrens, Timothy E. J.; Mars, Rogier B.; Rushworth, Matthew F. S.

2013-01-01

Brains use predictive models to facilitate the processing of expected stimuli or planned actions. Under a predictive model, surprising (low probability) stimuli or actions necessitate the immediate reallocation of processing resources, but they can also signal the need to update the underlying predictive model to reflect changes in the environment. Surprise and updating are often correlated in experimental paradigms but are, in fact, distinct constructs that can be formally defined as the Shannon information (IS) and Kullback–Leibler divergence (DKL) associated with an observation. In a saccadic planning task, we observed that distinct behaviors and brain regions are associated with surprise/IS and updating/DKL. Although surprise/IS was associated with behavioral reprogramming as indexed by slower reaction times, as well as with activity in the posterior parietal cortex [human lateral intraparietal area (LIP)], the anterior cingulate cortex (ACC) was specifically activated during updating of the predictive model (DKL). A second saccade-sensitive region in the inferior posterior parietal cortex (human 7a), which has connections to both LIP and ACC, was activated by surprise and modulated by updating. Pupillometry revealed a further dissociation between surprise and updating with an early positive effect of surprise and late negative effect of updating on pupil area. These results give a computational account of the roles of the ACC and two parietal saccade regions, LIP and 7a, by which their involvement in diverse tasks can be understood mechanistically. The dissociation of functional roles between regions within the reorienting/reprogramming network may also inform models of neurological phenomena, such as extinction and Balint syndrome, and neglect. PMID:23986499

Blunt impact as deterrent: human approach-avoidance behaviors and other stress responses studied within a paintball gaming context

NASA Astrophysics Data System (ADS)

Short, Kenneth R.; Bergen, Michael T.; DeMarco, Robert M.; Chua, Florence B.; Servatius, Richard J.

2006-05-01

Blunt impact munitions are often used by civilian law enforcement and in military operations on urban terrain (MOUT) missions to dissuade individuals and groups from approaching valued assets. The use of blunt munitions (rubber-ball or sponge) is predicated on their effectiveness as aversive stimuli; the effectiveness is weighed against the risk of serious injury or death. However, little empirical evidence supports effectiveness. Here, we use a paintball gaming context to study the effects of blunt impact on performance and approach behaviors. Volunteers individually traversed a course in which targets offer the opportunity to gain for accuracy. While completing the targeting task, subjects were bombarded with paintballs, which progressively became more numerous and the impact more intense as the subjects neared goal locations. Initial data suggest that over 30 blunt impacts by paintballs delivered at 280 ft/sec over 30 to 100 ft are insufficient to overcome intrinsic and extrinsic approach motivations or impair targeting or advance performance in an overwhelming majority of subjects. Our apparent ceiling effect was surprising. A sub-comparison of the few subjects who stopped the game before the end with those who did not suggests that personality factors influence the effectiveness of blunt impact as a deterrent. While paintballs differ from traditional blunt impact munitions on a number of physical characteristics, impact that was sufficient to repeatedly bruise volunteers was not an effective deterrent.

Surprise and Sense Making: Undergraduate Placement Experiences in SMEs

ERIC Educational Resources Information Center

Walmsley, Andreas; Thomas, Rhodri; Jameson, Stephanie

2006-01-01

Purpose: This paper seeks to explore undergraduate placement experiences in tourism and hospitality SMEs, focusing on the notions of surprise and sense making. It aims to argue that surprises and sense making are important elements not only of the adjustment process when entering new work environments, but also of the learning experience that…

Biophysical Controls on Carbon Cycling in Restored and Unrestored Urban Streams

NASA Astrophysics Data System (ADS)

Larsen, L. G.; Harvey, J. W.; Singh, J. D.; Sinclair, G. A.; Langston, T.; Maglio, M. M.

2012-12-01

Stream restoration is a multibillion dollar industry, yet how restoration impacts the ecological functioning of streams remains poorly understood. Because stream restoration may alter numerous biophysical controls, including light availability (through tree removal during bank regrading), hydraulics, sediment characteristics, and/or nutrient concentrations, it can be challenging to achieve a general understanding of how different aspects of stream restoration design influence ecosystem function (e.g., carbon cycling). In this study we combined strategies of continuously monitoring hydrology, turbidity, and dissolved oxygen at a station with spatially distributed but temporally sparse synoptic sampling to understand how restoration and land-use impact carbon fixation and respiration in urban streams. The study was performed over three years in three adjacent 3rd-4th order stream reaches in the urban Chesapeake Bay watershed, one of which was restored in 2002 using the ubiquitous Natural Channel Design method. By parsing the dissolved oxygen time series into contributions from respiration and gross primary production, we found the unrestored urban reach to be the most heterotrophic. It removed two times more carbon from the stream to the atmosphere than an unrestored suburban stream that was nutrient impacted and five times more carbon than the restored urban stream. The synoptic sampling revealed that nutrients, light, and hydrodynamic disturbance were the primary controls on carbon fixation and respiration, with fine sediment also exhibiting importance, likely as a vehicle for nutrient transport. Low rates of net carbon removal in the restored stream arose from high light availability resulting in high primary production, combined with low fine sediment availability restricting respiration. Thus, while restoration may have been effective for stream stabilization, it has decreased the functionality of the stream for net carbon removal to the atmosphere. Surprisingly, streambed potential respiration rates were indistinguishable between different geomorphic zones within the streams, suggesting that large-scale factors (i.e., nutrient and fine sediment supply) were more dominant controls than geomorphically controlled local variability.

Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis.

PubMed

Camassa, Serena; Palucci, Ivana; Iantomasi, Raffaella; Cubeddu, Tiziana; Minerva, Mariachiara; De Maio, Flavio; Jouny, Samuel; Petruccioli, Elisa; Goletti, Delia; Ria, Francesco; Sali, Michela; Sanguinetti, Maurizio; Manganelli, Riccardo; Rocca, Stefano; Brodin, Priscille; Delogu, Giovanni

2017-01-01

PE_PGRS33 is a surface-exposed protein of Mycobacterium tuberculosis ( Mtb ) which exerts its role in macrophages entry and immunomodulation. In this study, we aimed to investigate the polymorphisms in the pe_pgrs33 gene of Mtb clinical isolates and evaluate their impact on protein functions. We sequenced pe_pgrs33 in a collection of 135 clinical strains, genotyped by 15-loci MIRU-VNTR and spoligotyping and belonging to the Mtb complex (MTBC). Overall, an association between pe_pgrs33 alleles and MTBC genotypes was observed and a dN/dS ratio of 0.64 was obtained, suggesting that a purifying selective pressure is acting on pe_pgrs33 against deleterious SNPs. Among a total of 19 pe_pgrs33 alleles identified in this study, 5 were cloned and used to complement the pe_pgrs33 knock-out mutant strain of Mtb H37Rv ( Mtb Δ33) to assess the functional impact of the respective polymorphisms in in vitro infections of primary macrophages. In human monocyte-derived macrophages (MDMs) infection, large in-frame and frameshift mutations were unable to restore the phenotype of Mtb H37Rv, impairing the cell entry capacity of Mtb , but neither its intracellular replication rate nor its immunomodulatory properties. In vivo studies performed in the murine model of tuberculosis (TB) demonstrated that the Mtb Δ33 mutant strain was not impaired in the ability to infect and replicate in the lung tissue compared to the parental strain. Interestingly, Mtb Δ33 showed an enhanced virulence during the chronic steps of infection compared to Mtb H37Rv. Similarly, the complementation of Mtb Δ33 with a frameshift allele also resulted in a Mtb strain capable of causing a surprisingly enhanced tissue damage in murine lungs, during the chronic steps of infection. Together, these results further support the role of PE_PGRS33 in the pathogenesis and virulence of Mtb .

Essays in renewable energy and emissions trading

NASA Astrophysics Data System (ADS)

Kneifel, Joshua D.

Environmental issues have become a key political issue over the past forty years and has resulted in the enactment of many different environmental policies. The three essays in this dissertation add to the literature of renewable energy policies and sulfur dioxide emissions trading. The first essay ascertains which state policies are accelerating deployment of non-hydropower renewable electricity generation capacity into a states electric power industry. As would be expected, policies that lead to significant increases in actual renewable capacity in that state either set a Renewables Portfolio Standard with a certain level of required renewable capacity or use Clean Energy Funds to directly fund utility-scale renewable capacity construction. A surprising result is that Required Green Power Options, a policy that merely requires all utilities in a state to offer the option for consumers to purchase renewable energy at a premium rate, has a sizable impact on non-hydro renewable capacity in that state. The second essay studies the theoretical impacts fuel contract constraints have on an electricity generating unit's compliance costs of meeting the emissions compliance restrictions set by Phase I of the Title IV SO2 Emissions Trading Program. Fuel contract constraints restrict a utility's degrees of freedom in coal purchasing options, which can lead to the use of a more expensive compliance option and higher compliance costs. The third essay analytically and empirically shows how fuel contract constraints impact the emissions allowance market and total electric power industry compliance costs. This paper uses generating unit-level simulations to replicate results from previous studies and show that fuel contracts appear to explain a large portion (65%) of the previously unexplained compliance cost simulations. Also, my study considers a more appropriate plant-level decisions for compliance choices by analytically analyzing the plant level decision-making process to show how cost-minimization at the more complex plant level may deviate from cost-minimization at the generating unit level.

Decision aids for second-line palliative chemotherapy: a randomised phase II multicentre trial.

PubMed

Oostendorp, Linda J M; Ottevanger, Petronella B; Donders, A Rogier T; van de Wouw, Agnes J; Schoenaker, Ivonne J H; Smilde, Tineke J; van der Graaf, Winette T A; Stalmeier, Peep F M

2017-08-31

There is increasing recognition of the delicate balance between the modest benefits of palliative chemotherapy and the burden of treatment. Decision aids (DAs) can potentially help patients with advanced cancer with these difficult treatment decisions, but providing detailed information could have an adverse impact on patients' well-being. The objective of this randomised phase II study was to evaluate the safety and efficacy of DAs for patients with advanced cancer considering second-line chemotherapy. Patients with advanced breast or colorectal cancer considering second-line treatment were randomly assigned to usual care (control group) or usual care plus a DA (intervention group) in a 1:2 ratio. A nurse offered a DA with information on adverse events, tumour response and survival. Outcome measures included patient-reported well-being (primary outcome: anxiety) and quality of the decision-making process and the resulting choice. Of 128 patients randomised, 45 were assigned to the control group and 83 to the intervention group. Median age was 62 years (range 32-81), 63% were female, and 73% had colorectal cancer. The large majority of patients preferred treatment with chemotherapy (87%) and subsequently commenced treatment with chemotherapy (86%). No adverse impact on patients' well-being was found and nurses reported that consultations in which the DAs were offered went well. Being offered the DA was associated with stronger treatment preferences (3.0 vs. 2.5; p=0.030) and increased subjective knowledge (6.7 vs. 6.3; p=0.022). Objective knowledge, risk perception and perceived involvement were comparable between the groups. DAs containing detailed risk information on second-line palliative treatment could be delivered to patients with advanced cancer without having an adverse impact on patient well-being. Surprisingly, the DAs only marginally improved the quality of the decision-making process. The effectiveness of DAs for palliative treatment decisions needs further exploration. Netherlands Trial Registry (NTR): NTR1113 (registered on 2 November 2007).

Effect of temperature shock and inventory surprises on natural gas and heating oil futures returns.

PubMed

Hu, John Wei-Shan; Hu, Yi-Chung; Lin, Chien-Yu

2014-01-01

The aim of this paper is to examine the impact of temperature shock on both near-month and far-month natural gas and heating oil futures returns by extending the weather and storage models of the previous study. Several notable findings from the empirical studies are presented. First, the expected temperature shock significantly and positively affects both the near-month and far-month natural gas and heating oil futures returns. Next, significant temperature shock has effect on both the conditional mean and volatility of natural gas and heating oil prices. The results indicate that expected inventory surprises significantly and negatively affects the far-month natural gas futures returns. Moreover, volatility of natural gas futures returns is higher on Thursdays and that of near-month heating oil futures returns is higher on Wednesdays than other days. Finally, it is found that storage announcement for natural gas significantly affects near-month and far-month natural gas futures returns. Furthermore, both natural gas and heating oil futures returns are affected more by the weighted average temperature reported by multiple weather reporting stations than that reported by a single weather reporting station.

Effect of Temperature Shock and Inventory Surprises on Natural Gas and Heating Oil Futures Returns

PubMed Central

Hu, John Wei-Shan; Lin, Chien-Yu

2014-01-01

The aim of this paper is to examine the impact of temperature shock on both near-month and far-month natural gas and heating oil futures returns by extending the weather and storage models of the previous study. Several notable findings from the empirical studies are presented. First, the expected temperature shock significantly and positively affects both the near-month and far-month natural gas and heating oil futures returns. Next, significant temperature shock has effect on both the conditional mean and volatility of natural gas and heating oil prices. The results indicate that expected inventory surprises significantly and negatively affects the far-month natural gas futures returns. Moreover, volatility of natural gas futures returns is higher on Thursdays and that of near-month heating oil futures returns is higher on Wednesdays than other days. Finally, it is found that storage announcement for natural gas significantly affects near-month and far-month natural gas futures returns. Furthermore, both natural gas and heating oil futures returns are affected more by the weighted average temperature reported by multiple weather reporting stations than that reported by a single weather reporting station. PMID:25133233

PIV Measurements of Chevrons on F400 Tactical Aircraft Nozzle Model

NASA Technical Reports Server (NTRS)

Bridges, James; Wernet, Mark; Frate, Franco

2010-01-01

Previous talks at this meeting have covered our collaborative work on high-energy jets such as present in tactical aircraft (those with supersonic plumes). The emphasis of this work is improving our understanding of flow physics and our prediction tools. In this presentation we will discuss recent flow diagnostics acquired using Particle Image Velocimetry (PIV) made on an underexpanded shocked jet plume from a tactical aircraft nozzle. In this presentation we show cross-sectional and streamwise cuts of both mean and turbulent velocities of an F404 engine nozzle with various chevron designs applied. The impact of chevron penetration, length, and width are documented. The impact of the parameters is generally nonlinear in measures considered here, a surprising result given the relatively smooth behavior of the noise to variations in these chevron parameters.

Predatory senescence in ageing wolves.

PubMed

MacNulty, Daniel R; Smith, Douglas W; Vucetich, John A; Mech, L David; Stahler, Daniel R; Packer, Craig

2009-12-01

It is well established that ageing handicaps the ability of prey to escape predators, yet surprisingly little is known about how ageing affects the ability of predators to catch prey. Research into long-lived predators has assumed that adults have uniform impacts on prey regardless of age. Here we use longitudinal data from repeated observations of individually-known wolves (Canis lupus) hunting elk (Cervus elaphus) in Yellowstone National Park to demonstrate that adult predatory performance declines with age and that an increasing ratio of senescent individuals in the wolf population depresses the rate of prey offtake. Because this ratio fluctuates independently of population size, predatory senescence may cause wolf populations of equal size but different age structure to have different impacts on prey populations. These findings suggest that predatory senescence is an important, though overlooked, factor affecting predator-prey dynamics.

Adam M. Grant: Award for Distinguished Scientific Early Career Contributions to Psychology.

PubMed

2011-11-01

Presents Adam M. Grant, the 2011 winner of the American Psychological Association Award for Distinguished Scientific Early Career Contributions to Psychology. "For extensive, elegant, and programmatic research on the power of relational job design in enhancing employee motivation, productivity, and satisfaction; for creative and rigorous studies documenting the profound and surprising effects of connecting employees to their impact on others; for highlighting prosocial motivation, not only extrinsic and intrinsic motivations, as a key force behind employee behavior; and for demonstrating by example the feasibility and benefits of conducting field experiments, yielding studies rich in internal validity, external validity, and practical impact. In addition to his accomplishments, Adam M. Grant is known for his generosity as a scholar, teacher, and colleague." (PsycINFO Database Record (c) 2011 APA, all rights reserved). 2011 APA, all rights reserved

Predatory senescence in ageing wolves

USGS Publications Warehouse

MacNulty, D.R.; Smith, D.W.; Vucetich, J.A.; Mech, L.D.; Stahler, D.R.; Packer, C.

2009-01-01

It is well established that ageing handicaps the ability of prey to escape predators, yet surprisingly little is known about how ageing affects the ability of predators to catch prey. Research into long-lived predators has assumed that adults have uniform impacts on prey regardless of age. Here we use longitudinal data from repeated observations of individually-known wolves (Canis lupus) hunting elk (Cervus elaphus) in Yellowstone National Park to demonstrate that adult predatory performance declines with age and that an increasing ratio of senescent individuals in the wolf population depresses the rate of prey offtake. Because this ratio fluctuates independently of population size, predatory senescence may cause wolf populations of equal size but different age structure to have different impacts on prey populations. These findings suggest that predatory senescence is an important, though overlooked, factor affecting predator-prey dynamics. ?? 2009 Blackwell Publishing Ltd/CNRS.