GASP- General Aviation Synthesis Program. Volume 1: Main program. Part 1: Theoretical development

NASA Technical Reports Server (NTRS)

Hague, D.

1978-01-01

The General Aviation synthesis program performs tasks generally associated with aircraft preliminary design and allows an analyst the capability of performing parametric studies in a rapid manner. GASP emphasizes small fixed-wing aircraft employing propulsion systems varying froma single piston engine with fixed pitch propeller through twin turboprop/ turbofan powered business or transport type aircraft. The program, which may be operated from a computer terminal in either the batch or interactive graphic mode, is comprised of modules representing the various technical disciplines integrated into a computational flow which ensures that the interacting effects of design variables are continuously accounted for in the aircraft sizing procedure. The model is a useful tool for comparing configurations, assessing aircraft performance and economics, performing tradeoff and sensitivity studies, and assessing the impact of advanced technologies on aircraft performance and economics.

Airborne forest fire research

NASA Technical Reports Server (NTRS)

Mattingly, G. S.

1974-01-01

The research relating to airborne fire fighting systems is reviewed to provide NASA/Langley Research Center with current information on the use of aircraft in forest fire operations, and to identify research requirements for future operations. A literature survey, interview of forest fire service personnel, analysis and synthesis of data from research reports and independent conclusions, and recommendations for future NASA-LRC programs are included.

Field Operational Seminar in Functional Literacy Linked with Population Education and Family Planning (Indonesia, February 26-March 18, 1973). Synthesis of the Final Report.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and Oceania.

The primary objectives of this seminar was to provide concrete and diversified field experiences in functional literacy approaches, principles, methods and techniques carried out within the framework of an ongoing population education and family planning program. Included in the report are an introduction, general operational procedures…

Electronic Toll And Traffic Management Systems, National Cooperative Highway Research Program Synthesis

DOT National Transportation Integrated Search

1993-01-01

ELECTRONIC TOLL COLLECTION OR ETC AND TRAFFIC MANAGEMENT OR ETTM, AUTOMATIC VEHICLE IDENTIFICATION OR AVI : ELECTRONIC TOLL COLLECTION AND TRAFFIC MANAGEMENT (ETTM) SYSTEMS ARE NOT A FUTURISTIC DREAM, THEY ARE OPERATING OR ARE BEING TESTED TODAY I...

Program on application of communications satellites to educational development

NASA Technical Reports Server (NTRS)

Morgan, R. P.; Singh, J. P.

1971-01-01

Interdisciplinary research in needs analysis, communications technology studies, and systems synthesis is reported. Existing and planned educational telecommunications services are studied and library utilization of telecommunications is described. Preliminary estimates are presented of ranges of utilization of educational telecommunications services for 1975 and 1985; instructional and public television, computer-aided instruction, computing resources, and information resource sharing for various educational levels and purposes. Communications technology studies include transmission schemes for still-picture television, use of Gunn effect devices, and TV receiver front ends for direct satellite reception at 12 GHz. Two major studies in the systems synthesis project concern (1) organizational and administrative aspects of a large-scale instructional satellite system to be used with schools and (2) an analysis of future development of instructional television, with emphasis on the use of video tape recorders and cable television. A communications satellite system synthesis program developed for NASA is now operational on the university IBM 360-50 computer.

New frontiers in design synthesis

NASA Technical Reports Server (NTRS)

Goldin, D. S.; Venneri, S. L.; Noor, A. K.

1999-01-01

The Intelligent Synthesis Environment (ISE), which is one of the major strategic technologies under development at NASA centers and the University of Virginia, is described. One of the major objectives of ISE is to significantly enhance the rapid creation of innovative affordable products and missions. ISE uses a synergistic combination of leading-edge technologies, including high performance computing, high capacity communications and networking, human-centered computing, knowledge-based engineering, computational intelligence, virtual product development, and product information management. The environment will link scientists, design teams, manufacturers, suppliers, and consultants who participate in the mission synthesis as well as in the creation and operation of the aerospace system. It will radically advance the process by which complex science missions are synthesized, and high-tech engineering Systems are designed, manufactured and operated. The five major components critical to ISE are human-centered computing, infrastructure for distributed collaboration, rapid synthesis and simulation tools, life cycle integration and validation, and cultural change in both the engineering and science creative process. The five components and their subelements are described. Related U.S. government programs are outlined and the future impact of ISE on engineering research and education is discussed.

Working with Value: Industry-Specific Approaches to Workforce Development. A Synthesis of Findings.

ERIC Educational Resources Information Center

Rademacher, Ida, Ed.

Multi-year applied research studied operations and outcomes of six employment initiatives that developed industry-based approaches to workforce development. Findings from the longitudinal survey of 732 individuals indicated participants in sectoral programs improved their position within local labor markets; increased wages, hours worked, and…

Advanced space program studies. Overall executive summary

NASA Technical Reports Server (NTRS)

Wolfe, M. G.

1977-01-01

NASA and DoD requirements and planning data were used in multidiscipline advanced planning investigations of space operations and associated elements (including man), identification of potential low cost approaches, vehicle design, cost synthesis techniques, technology forecasting and opportunities for DoD technology transfer, and the development near-, mid-, and far-term space initiatives and development plans with emphasis on domestic and military commonality. An overview of objectives and results are presented for the following studies: advanced space planning and conceptual analysis, shuttle users, technology assessment and new opportunities, standardization and program practice, integrated STS operations planning, solid spinning upper stage, and integrated planning support functions.

RPython high-level synthesis

NASA Astrophysics Data System (ADS)

Cieszewski, Radoslaw; Linczuk, Maciej

2016-09-01

The development of FPGA technology and the increasing complexity of applications in recent decades have forced compilers to move to higher abstraction levels. Compilers interprets an algorithmic description of a desired behavior written in High-Level Languages (HLLs) and translate it to Hardware Description Languages (HDLs). This paper presents a RPython based High-Level synthesis (HLS) compiler. The compiler get the configuration parameters and map RPython program to VHDL. Then, VHDL code can be used to program FPGA chips. In comparison of other technologies usage, FPGAs have the potential to achieve far greater performance than software as a result of omitting the fetch-decode-execute operations of General Purpose Processors (GPUs), and introduce more parallel computation. This can be exploited by utilizing many resources at the same time. Creating parallel algorithms computed with FPGAs in pure HDL is difficult and time consuming. Implementation time can be greatly reduced with High-Level Synthesis compiler. This article describes design methodologies and tools, implementation and first results of created VHDL backend for RPython compiler.

Deductive Glue Code Synthesis for Embedded Software Systems Based on Code Patterns

NASA Technical Reports Server (NTRS)

Liu, Jian; Fu, Jicheng; Zhang, Yansheng; Bastani, Farokh; Yen, I-Ling; Tai, Ann; Chau, Savio N.

2006-01-01

Automated code synthesis is a constructive process that can be used to generate programs from specifications. It can, thus, greatly reduce the software development cost and time. The use of formal code synthesis approach for software generation further increases the dependability of the system. Though code synthesis has many potential benefits, the synthesis techniques are still limited. Meanwhile, components are widely used in embedded system development. Applying code synthesis to component based software development (CBSD) process can greatly enhance the capability of code synthesis while reducing the component composition efforts. In this paper, we discuss the issues and techniques for applying deductive code synthesis techniques to CBSD. For deductive synthesis in CBSD, a rule base is the key for inferring appropriate component composition. We use the code patterns to guide the development of rules. Code patterns have been proposed to capture the typical usages of the components. Several general composition operations have been identified to facilitate systematic composition. We present the technique for rule development and automated generation of new patterns from existing code patterns. A case study of using this method in building a real-time control system is also presented.

ODIN system technology module library, 1972 - 1973

NASA Technical Reports Server (NTRS)

Hague, D. S.; Watson, D. A.; Glatt, C. R.; Jones, R. T.; Galipeau, J.; Phoa, Y. T.; White, R. J.

1978-01-01

ODIN/RLV is a digital computing system for the synthesis and optimization of reusable launch vehicle preliminary designs. The system consists of a library of technology modules in the form of independent computer programs and an executive program, ODINEX, which operates on the technology modules. The technology module library contains programs for estimating all major military flight vehicle system characteristics, for example, geometry, aerodynamics, economics, propulsion, inertia and volumetric properties, trajectories and missions, steady state aeroelasticity and flutter, and stability and control. A general system optimization module, a computer graphics module, and a program precompiler are available as user aids in the ODIN/RLV program technology module library.

A study of commuter airplane design optimization

NASA Technical Reports Server (NTRS)

Roskam, J.; Wyatt, R. D.; Griswold, D. A.; Hammer, J. L.

1977-01-01

Problems of commuter airplane configuration design were studied to affect a minimization of direct operating costs. Factors considered were the minimization of fuselage drag, methods of wing design, and the estimated drag of an airplane submerged in a propellor slipstream; all design criteria were studied under a set of fixed performance, mission, and stability constraints. Configuration design data were assembled for application by a computerized design methodology program similar to the NASA-Ames General Aviation Synthesis Program.

Intelligent transportation systems Professional Capacity Building Program : ITS training & education needs assessment baseline : a review and synthesis of thirteen prior studies, field interviews, and a summary assessment of ITS needs

DOT National Transportation Integrated Search

1997-12-01

Successful deployment, operation, and management of Intelligent Transportation Systems (ITS) requires a new breed of transportation professionals, according to research, extensive outreach, and information gathered to date. The U.S. DOT has responded...

Solid State Division progress report for period ending March 31, 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, P.H.; Hinton, L.W.

1992-09-01

During this period, the division conducted a broad, interdisciplinary materials research program with emphasis on theoretical solid state physics, superconductivity, neutron scattering, synthesis and characterization of materials, ion beam and laser processing, and the structure of solids and surfaces. The High Flux Isotope Reactor was returned to full operation.

Automation of Shuttle Tile Inspection - Engineering methodology for Space Station

NASA Technical Reports Server (NTRS)

Wiskerchen, M. J.; Mollakarimi, C.

1987-01-01

The Space Systems Integration and Operations Research Applications (SIORA) Program was initiated in late 1986 as a cooperative applications research effort between Stanford University, NASA Kennedy Space Center, and Lockheed Space Operations Company. One of the major initial SIORA tasks was the application of automation and robotics technology to all aspects of the Shuttle tile processing and inspection system. This effort has adopted a systems engineering approach consisting of an integrated set of rapid prototyping testbeds in which a government/university/industry team of users, technologists, and engineers test and evaluate new concepts and technologies within the operational world of Shuttle. These integrated testbeds include speech recognition and synthesis, laser imaging inspection systems, distributed Ada programming environments, distributed relational database architectures, distributed computer network architectures, multimedia workbenches, and human factors considerations.

Adding Concrete Syntax to a Prolog-Based Program Synthesis System

NASA Technical Reports Server (NTRS)

Fischer, Bernd; Visser, Eelco

2004-01-01

Program generation and transformation systems work on two language levels, the object-level (i e., the language of the manipulated programs), and the meta-level (i.e., the implementation language of the system itself). The meta-level representations of object-level program fragments are usually built in an essentially syntax-free fashion using the operations provided by the meta-language. However, syntax matters and a large conceptual distance between the two languages makes it difficult to maintain and extend such systems. Here we describe how an existing Prolog-based system can gradually be retrofitted with concrete object-level syntax, thus shrinking this distance.

Algorithmic synthesis using Python compiler

NASA Astrophysics Data System (ADS)

Cieszewski, Radoslaw; Romaniuk, Ryszard; Pozniak, Krzysztof; Linczuk, Maciej

2015-09-01

This paper presents a python to VHDL compiler. The compiler interprets an algorithmic description of a desired behavior written in Python and translate it to VHDL. FPGA combines many benefits of both software and ASIC implementations. Like software, the programmed circuit is flexible, and can be reconfigured over the lifetime of the system. FPGAs have the potential to achieve far greater performance than software as a result of bypassing the fetch-decode-execute operations of traditional processors, and possibly exploiting a greater level of parallelism. This can be achieved by using many computational resources at the same time. Creating parallel programs implemented in FPGAs in pure HDL is difficult and time consuming. Using higher level of abstraction and High-Level Synthesis compiler implementation time can be reduced. The compiler has been implemented using the Python language. This article describes design, implementation and results of created tools.

Commercial-scale demonstration of the Liquid Phase Methanol (LPMEOH{trademark}) process. Technical progress report number 6, October 1--December 31, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-12-31

The project involves the construction of an 80,000 gallons per day (260 TPD) methanol unit utilizing coal-derived synthesis gas from Eastman`s integrated coal gasification facility. The new equipment consists of synthesis gas feed preparation and compression facilities, the liquid phase reactor and auxiliaries, product distillation facilities, and utilities. The technology to be demonstrated is the product of a cooperative development effort by Air Products and DOE in a program that started in 1981. Developed to enhance electric power generation using integrated gasification combined cycle (IGCC) technology, the LPMEOH{trademark} process is ideally suited for directly processing gases produced by modern-day coalmore » gasifiers. This liquid phase process suspends fine catalyst particles in an inert liquid, forming a slurry. The slurry dissipates the heat of the chemical reaction away from the catalyst surface protecting the catalyst and allowing the methanol synthesis reaction to proceed at higher rates. At the Eastman complex, the technology will be integrated with existing coal-gasifiers. A carefully developed test plan will allow operations at Eastman to simulate electricity demand load-following in coal-based IGCC facilities. The operations will also demonstrate the enhanced stability and heat dissipation of the conversion process, its reliable on/off operation, and its ability to produce methanol as a clean liquid fuel without additional upgrading. An off-site product testing program will be conducted to demonstrate the suitability of the methanol product as a transportation fuel and as a fuel for stationary applications for small modular electric power generators for distributed power.« less

Optimal synthesis and design of the number of cycles in the leaching process for surimi production.

PubMed

Reinheimer, M Agustina; Scenna, Nicolás J; Mussati, Sergio F

2016-12-01

Water consumption required during the leaching stage in the surimi manufacturing process strongly depends on the design and the number and size of stages connected in series for the soluble protein extraction target, and it is considered as the main contributor to the operating costs. Therefore, the optimal synthesis and design of the leaching stage is essential to minimize the total annual cost. In this study, a mathematical optimization model for the optimal design of the leaching operation is presented. Precisely, a detailed Mixed Integer Nonlinear Programming (MINLP) model including operating and geometric constraints was developed based on our previous optimization model (NLP model). Aspects about quality, water consumption and main operating parameters were considered. The minimization of total annual costs, which considered a trade-off between investment and operating costs, led to an optimal solution with lesser number of stages (2 instead of 3 stages) and higher volumes of the leaching tanks comparing with previous results. An analysis was performed in order to investigate how the optimal solution was influenced by the variations of the unitary cost of fresh water, waste treatment and capital investment.

Python based high-level synthesis compiler

NASA Astrophysics Data System (ADS)

Cieszewski, Radosław; Pozniak, Krzysztof; Romaniuk, Ryszard

2014-11-01

This paper presents a python based High-Level synthesis (HLS) compiler. The compiler interprets an algorithmic description of a desired behavior written in Python and map it to VHDL. FPGA combines many benefits of both software and ASIC implementations. Like software, the mapped circuit is flexible, and can be reconfigured over the lifetime of the system. FPGAs therefore have the potential to achieve far greater performance than software as a result of bypassing the fetch-decode-execute operations of traditional processors, and possibly exploiting a greater level of parallelism. Creating parallel programs implemented in FPGAs is not trivial. This article describes design, implementation and first results of created Python based compiler.

Whitebark Pine Germination, Rust Resistance, and Cold Hardiness Among Seed Sources in the Inland Northwest: Planting Strategies for Restoration

Treesearch

Mary F. Mahalovich; Karen E. Burr; David L. Foushee

2006-01-01

A synthesis of several studies highlights above-average performing seed sources (n = 108) of whitebark pine (Pinus albicaulis), which practitioners can utilize for restoration, wildlife habitat improvement, and operational planting programs. It is the first report of this magnitude of blister rust resistance for this species. Whitebark pine does have...

Design synthesis and optimization of joined-wing transports

NASA Technical Reports Server (NTRS)

Gallman, John W.; Smith, Stephen C.; Kroo, Ilan M.

1990-01-01

A computer program for aircraft synthesis using a numerical optimizer was developed to study the application of the joined-wing configuration to transport aircraft. The structural design algorithm included the effects of secondary bending moments to investigate the possibility of tail buckling and to design joined wings resistant to buckling. The structural weight computed using this method was combined with a statistically-based method to obtain realistic estimates of total lifting surface weight and aircraft empty weight. A variety of 'optimum' joined-wing and conventional aircraft designs were compared on the basis of direct operating cost, gross weight, and cruise drag. The most promising joined-wing designs were found to have a joint location at about 70 percent of the wing semispan. The optimum joined-wing transport is shown to save 1.7 percent in direct operating cost and 11 percent in drag for a 2000 nautical mile transport mission.

Adaptable structural synthesis using advanced analysis and optimization coupled by a computer operating system

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, J.; Bhat, R. B.

1979-01-01

A finite element program is linked with a general purpose optimization program in a 'programing system' which includes user supplied codes that contain problem dependent formulations of the design variables, objective function and constraints. The result is a system adaptable to a wide spectrum of structural optimization problems. In a sample of numerical examples, the design variables are the cross-sectional dimensions and the parameters of overall shape geometry, constraints are applied to stresses, displacements, buckling and vibration characteristics, and structural mass is the objective function. Thin-walled, built-up structures and frameworks are included in the sample. Details of the system organization and characteristics of the component programs are given.

AutoBayes Program Synthesis System System Internals

NASA Technical Reports Server (NTRS)

Schumann, Johann Martin

2011-01-01

This lecture combines the theoretical background of schema based program synthesis with the hands-on study of a powerful, open-source program synthesis system (Auto-Bayes). Schema-based program synthesis is a popular approach toward program synthesis. The lecture will provide an introduction into this topic and discuss how this technology can be used to generate customized algorithms. The synthesis of advanced numerical algorithms requires the availability of a powerful symbolic (algebra) system. Its task is to symbolically solve equations, simplify expressions, or to symbolically calculate derivatives (among others) such that the synthesized algorithms become as efficient as possible. We will discuss the use and importance of the symbolic system for synthesis. Any synthesis system is a large and complex piece of code. In this lecture, we will study Autobayes in detail. AutoBayes has been developed at NASA Ames and has been made open source. It takes a compact statistical specification and generates a customized data analysis algorithm (in C/C++) from it. AutoBayes is written in SWI Prolog and many concepts from rewriting, logic, functional, and symbolic programming. We will discuss the system architecture, the schema libary and the extensive support infra-structure. Practical hands-on experiments and exercises will enable the student to get insight into a realistic program synthesis system and provides knowledge to use, modify, and extend Autobayes.

Transformational derivation of programs using the Focus system

NASA Technical Reports Server (NTRS)

Reddy, Uday S.

1988-01-01

A program derivation support system called Focus is being constructed. It will formally derive programs using the paradigm of program transformation. The following issues are discussed: (1) the integration of validation and program derivation activities in the Focus system; (2) its tree-based user interface; (3) the control of search spaces in program derivation; and (4) the structure and organization of program derivation records. The inference procedures of the system are based on the integration of functional and logic programming principles. This brings about a synthesis of paradigms that were heretofore considered far apart, such as logical and executable specifications and constructive and transformational approaches to program derivation. A great emphasis has been placed, in the design of Focus, on achieving small search spaces during program derivation. The program manipulation operations such as expansion, simplification and rewriting were designed with this objective. The role of operations that are expensive in search spaces, such as folding, has been reduced. Program derivations are documented in Focus in a way that the high level descriptions of derivations are expressed only using program level information. All the meta-level information, together with dependencies between derivations of program components, is automatically recorded by the system at a lower level of description for its own use in replay.

NASA's CSTI Earth-to-Orbit Propulsion Program - On-target technology transfer to advanced space flight programs

NASA Technical Reports Server (NTRS)

Escher, William J. D.; Herr, Paul N.; Stephenson, Frank W., Jr.

1990-01-01

NASA's Civil Space Technology Initiative encompasses among its major elements the Earth-to-Orbit Propulsion Program (ETOPP) for future launch vehicles, which is budgeted to the extent of $20-30 million/year for the development of essential technologies. ETOPP technologies include, in addition to advanced materials and processes and design/analysis computational tools, the advanced systems-synthesis technologies required for definition of highly reliable LH2 and hydrocarbon fueled rocket engines to be operated at significantly reduced levels of risk and cost relative to the SSME. Attention is given to the technology-transfer services of ETOPP.

Study to determine potential flight applications and human factors design guidelines for voice recognition and synthesis systems

NASA Astrophysics Data System (ADS)

White, R. W.; Parks, D. L.

1985-07-01

A study was conducted to determine potential commercial aircraft flight deck applications and implementation guidelines for voice recognition and synthesis. At first, a survey of voice recognition and synthesis technology was undertaken to develop a working knowledge base. Then, numerous potential aircraft and simulator flight deck voice applications were identified and each proposed application was rated on a number of criteria in order to achieve an overall payoff rating. The potential voice recognition applications fell into five general categories: programming, interrogation, data entry, switch and mode selection, and continuous/time-critical action control. The ratings of the first three categories showed the most promise of being beneficial to flight deck operations. Possible applications of voice synthesis systems were categorized as automatic or pilot selectable and many were rated as being potentially beneficial. In addition, voice system implementation guidelines and pertinent performance criteria are proposed. Finally, the findings of this study are compared with those made in a recent NASA study of a 1995 transport concept.

Study to determine potential flight applications and human factors design guidelines for voice recognition and synthesis systems

NASA Technical Reports Server (NTRS)

White, R. W.; Parks, D. L.

1985-01-01

A study was conducted to determine potential commercial aircraft flight deck applications and implementation guidelines for voice recognition and synthesis. At first, a survey of voice recognition and synthesis technology was undertaken to develop a working knowledge base. Then, numerous potential aircraft and simulator flight deck voice applications were identified and each proposed application was rated on a number of criteria in order to achieve an overall payoff rating. The potential voice recognition applications fell into five general categories: programming, interrogation, data entry, switch and mode selection, and continuous/time-critical action control. The ratings of the first three categories showed the most promise of being beneficial to flight deck operations. Possible applications of voice synthesis systems were categorized as automatic or pilot selectable and many were rated as being potentially beneficial. In addition, voice system implementation guidelines and pertinent performance criteria are proposed. Finally, the findings of this study are compared with those made in a recent NASA study of a 1995 transport concept.

Effects of geldanamycin and thalidomide on the Th1/Th2 cytokine balance in mice subjected to operative trauma.

PubMed

Nakano, Takumi; Araki, Keijiro; Nakatani, Hajime; Kobayashi, Michiya; Sugimoto, Takeki; Furuya, Yasuo; Matsuoka, Takanori; Jin, Toufeng; Hanazaki, Kazuhiro

2007-04-01

Persistence of postoperative immune dysfunction is a critical problem because it increases the risk of serious infectious complications. The mechanisms of the immune dysfunction that occur initially after non-thermal operative injury remain to be fully elucidated. Two mouse models of operative trauma (simple laparotomy to represent minor operative injury and ileocecal resection to represent major operative injury) were used to define the characteristics of initial cytokine synthesis. Geldanamycin and thalidomide were independently added intraperitoneally before and after operative injury to examine the effect on postoperative immune dysfunction. Mice were sacrificed at scheduled times (3, 6, 12, and 24 h after operative injury) and TNF-alpha, IL-2, IL-4, and IL-10 were analyzed. Spleen was used for intracellular cytokines and RT-PCR. Sera were used for ELISA. Major operative injury caused an initial upregulation of IL-10 synthesis with delayed synthesis of TNF-alpha and IL-2. Minor operative injury caused an early induction of IL-2 synthesis preceded by an initial induction of IL-4 synthesis. GA caused a specific early upregulation of TNF-alpha mRNA expression and intracellular TNF-alpha synthesis. The GA and THD groups showed early serum IL-2 production with reduction of IL-10 mRNA expression and intracellular IL-10 synthesis in the early post-operative phase. Major and minor operative injury showed different Th1/Th2 cytokine patterns in the initial post-operative period. Geldanamycin and thalidomide improved the Th1/Th2 imbalance independently after major operative injury.

Synthesizing Certified Code

NASA Technical Reports Server (NTRS)

Whalen, Michael; Schumann, Johann; Fischer, Bernd

2002-01-01

Code certification is a lightweight approach to demonstrate software quality on a formal level. Its basic idea is to require producers to provide formal proofs that their code satisfies certain quality properties. These proofs serve as certificates which can be checked independently. Since code certification uses the same underlying technology as program verification, it also requires many detailed annotations (e.g., loop invariants) to make the proofs possible. However, manually adding theses annotations to the code is time-consuming and error-prone. We address this problem by combining code certification with automatic program synthesis. We propose an approach to generate simultaneously, from a high-level specification, code and all annotations required to certify generated code. Here, we describe a certification extension of AUTOBAYES, a synthesis tool which automatically generates complex data analysis programs from compact specifications. AUTOBAYES contains sufficient high-level domain knowledge to generate detailed annotations. This allows us to use a general-purpose verification condition generator to produce a set of proof obligations in first-order logic. The obligations are then discharged using the automated theorem E-SETHEO. We demonstrate our approach by certifying operator safety for a generated iterative data classification program without manual annotation of the code.

Undergraduate Research as Chemical Education--A Symposium: An Undergraduate Laboratory Experiment: The Total Synthesis of Maytansine.

ERIC Educational Resources Information Center

Goodwin, Thomas E.

1984-01-01

An undergraduate research program in natural product synthesis was established at a small liberal arts college. Discusses program goals (including the total synthesis of maytansine), objectives, and accomplishments to date. Guidelines for establishing such programs are offered. (JN)

Application of the MNA design method to a nonlinear turbofan engine. [multivariable Nyquist array method

NASA Technical Reports Server (NTRS)

Leininger, G. G.

1981-01-01

Using nonlinear digital simulation as a representative model of the dynamic operation of the QCSEE turbofan engine, a feedback control system is designed by variable frequency design techniques. Transfer functions are generated for each of five power level settings covering the range of operation from approach power to full throttle (62.5% to 100% full power). These transfer functions are then used by an interactive control system design synthesis program to provide a closed loop feedback control using the multivariable Nyquist array and extensions to multivariable Bode diagrams and Nichols charts.

Space Interferometry Mission: Measuring the Universe

NASA Technical Reports Server (NTRS)

Marr, James; Dallas, Saterios; Laskin, Robert; Unwin, Stephen; Yu, Jeffrey

1991-01-01

The Space Interferometry Mission (SIM) will be the NASA Origins Program's first space based long baseline interferometric observatory. SIM will use a 10 m Michelson stellar interferometer to provide 4 microarcsecond precision absolute position measurements of stars down to 20th magnitude over its 5 yr. mission lifetime. SIM will also provide technology demonstrations of synthesis imaging and interferometric nulling. This paper describes the what, why and how of the SIM mission, including an overall mission and system description, science objectives, general description of how SIM makes its measurements, description of the design concepts now under consideration, operations concept, and supporting technology program.

Shuttle user analysis (study 2.2): Volume 3. Business Risk And Value of Operations in space (BRAVO). Part 4: Computer programs and data look-up

NASA Technical Reports Server (NTRS)

1974-01-01

Computer program listings as well as graphical and tabulated data needed by the analyst to perform a BRAVO analysis were examined. Graphical aid which can be used to determine the earth coverage of satellites in synchronous equatorial orbits was described. A listing for satellite synthesis computer program as well as a sample printout for the DSCS-11 satellite program and a listing of the symbols used in the program were included. The APL language listing for the payload program cost estimating computer program was given. This language is compatible with many of the time sharing remote terminals computers used in the United States. Data on the intelsat communications network was studied. Costs for telecommunications systems leasing, line of sight microwave relay communications systems, submarine telephone cables, and terrestrial power generation systems were also described.

Design and implementation in VHDL code of the two-dimensional fast Fourier transform for frequency filtering, convolution and correlation operations

NASA Astrophysics Data System (ADS)

Vilardy, Juan M.; Giacometto, F.; Torres, C. O.; Mattos, L.

2011-01-01

The two-dimensional Fast Fourier Transform (FFT 2D) is an essential tool in the two-dimensional discrete signals analysis and processing, which allows developing a large number of applications. This article shows the description and synthesis in VHDL code of the FFT 2D with fixed point binary representation using the programming tool Simulink HDL Coder of Matlab; showing a quick and easy way to handle overflow, underflow and the creation registers, adders and multipliers of complex data in VHDL and as well as the generation of test bench for verification of the codes generated in the ModelSim tool. The main objective of development of the hardware architecture of the FFT 2D focuses on the subsequent completion of the following operations applied to images: frequency filtering, convolution and correlation. The description and synthesis of the hardware architecture uses the XC3S1200E family Spartan 3E FPGA from Xilinx Manufacturer.

Automatic Program Synthesis Reports.

ERIC Educational Resources Information Center

Biermann, A. W.; And Others

Some of the major results of future goals of an automatic program synthesis project are described in the two papers that comprise this document. The first paper gives a detailed algorithm for synthesizing a computer program from a trace of its behavior. Since the algorithm involves a search, the length of time required to do the synthesis of…

Design of RISC Processor Using VHDL and Cadence

NASA Astrophysics Data System (ADS)

Moslehpour, Saeid; Puliroju, Chandrasekhar; Abu-Aisheh, Akram

The project deals about development of a basic RISC processor. The processor is designed with basic architecture consisting of internal modules like clock generator, memory, program counter, instruction register, accumulator, arithmetic and logic unit and decoder. This processor is mainly used for simple general purpose like arithmetic operations and which can be further developed for general purpose processor by increasing the size of the instruction register. The processor is designed in VHDL by using Xilinx 8.1i version. The present project also serves as an application of the knowledge gained from past studies of the PSPICE program. The study will show how PSPICE can be used to simplify massive complex circuits designed in VHDL Synthesis. The purpose of the project is to explore the designed RISC model piece by piece, examine and understand the Input/ Output pins, and to show how the VHDL synthesis code can be converted to a simplified PSPICE model. The project will also serve as a collection of various research materials about the pieces of the circuit.

Adaptation of a software development methodology to the implementation of a large-scale data acquisition and control system. [for Deep Space Network

NASA Technical Reports Server (NTRS)

Madrid, G. A.; Westmoreland, P. T.

1983-01-01

A progress report is presented on a program to upgrade the existing NASA Deep Space Network in terms of a redesigned computer-controlled data acquisition system for channelling tracking, telemetry, and command data between a California-based control center and three signal processing centers in Australia, California, and Spain. The methodology for the improvements is oriented towards single subsystem development with consideration for a multi-system and multi-subsystem network of operational software. Details of the existing hardware configurations and data transmission links are provided. The program methodology includes data flow design, interface design and coordination, incremental capability availability, increased inter-subsystem developmental synthesis and testing, system and network level synthesis and testing, and system verification and validation. The software has been implemented thus far to a 65 percent completion level, and the methodology being used to effect the changes, which will permit enhanced tracking and communication with spacecraft, has been concluded to feature effective techniques.

Comparison of Analysis Results Between 2D/1D Synthesis and RAPTOR-M3G in the Korea Standard Nuclear Plant (KSNP)

NASA Astrophysics Data System (ADS)

Joung Lim, Mi; Maeng, Young Jae; Fero, Arnold H.; Anderson, Stanwood L.

2016-02-01

The 2D/1D synthesis methodology has been used to calculate the fast neutron (E > 1.0 MeV) exposure to the beltline region of the reactor pressure vessel. This method uses the DORT 3.1 discrete ordinates code and the BUGLE-96 cross-section library based on ENDF/B-VI. RAPTOR-M3G (RApid Parallel Transport Of Radiation-Multiple 3D Geometries) which performs full 3D calculations was developed and is based on domain decomposition algorithms, where the spatial and angular domains are allocated and processed on multi-processor computer architecture. As compared to traditional single-processor applications, this approach reduces the computational load as well as the memory requirement per processor. Both methods are applied to surveillance test results for the Korea Standard Nuclear Plant (KSNP)-OPR (Optimized Power Reactor) 1000 MW. The objective of this paper is to compare the results of the KSNP surveillance program between 2D/1D synthesis and RAPTOR-M3G. Each operating KSNP has a reactor vessel surveillance program consisting of six surveillance capsules located between the core and the reactor vessel in the downcomer region near the reactor vessel wall. In addition to the In-Vessel surveillance program, an Ex-Vessel Neutron Dosimetry (EVND) program has been implemented. In order to estimate surveillance test results, cycle-specific forward transport calculations were performed by 2D/1D synthesis and by RAPTOR-M3G. The ratio between measured and calculated (M/C) reaction rates will be discussed. The current plan is to install an EVND system in all of the Korea PWRs including the new reactor type, APR (Advanced Power Reactor) 1400 MW. This work will play an important role in establishing a KSNP-specific database of surveillance test results and will employ RAPTOR-M3G for surveillance dosimetry location as well as positions in the KSNP reactor vessel.

Software-based high-level synthesis design of FPGA beamformers for synthetic aperture imaging.

PubMed

Amaro, Joao; Yiu, Billy Y S; Falcao, Gabriel; Gomes, Marco A C; Yu, Alfred C H

2015-05-01

Field-programmable gate arrays (FPGAs) can potentially be configured as beamforming platforms for ultrasound imaging, but a long design time and skilled expertise in hardware programming are typically required. In this article, we present a novel approach to the efficient design of FPGA beamformers for synthetic aperture (SA) imaging via the use of software-based high-level synthesis techniques. Software kernels (coded in OpenCL) were first developed to stage-wise handle SA beamforming operations, and their corresponding FPGA logic circuitry was emulated through a high-level synthesis framework. After design space analysis, the fine-tuned OpenCL kernels were compiled into register transfer level descriptions to configure an FPGA as a beamformer module. The processing performance of this beamformer was assessed through a series of offline emulation experiments that sought to derive beamformed images from SA channel-domain raw data (40-MHz sampling rate, 12 bit resolution). With 128 channels, our FPGA-based SA beamformer can achieve 41 frames per second (fps) processing throughput (3.44 × 10(8) pixels per second for frame size of 256 × 256 pixels) at 31.5 W power consumption (1.30 fps/W power efficiency). It utilized 86.9% of the FPGA fabric and operated at a 196.5 MHz clock frequency (after optimization). Based on these findings, we anticipate that FPGA and high-level synthesis can together foster rapid prototyping of real-time ultrasound processor modules at low power consumption budgets.

Traceability Through Automatic Program Generation

NASA Technical Reports Server (NTRS)

Richardson, Julian; Green, Jeff

2003-01-01

Program synthesis is a technique for automatically deriving programs from specifications of their behavior. One of the arguments made in favour of program synthesis is that it allows one to trace from the specification to the program. One way in which traceability information can be derived is to augment the program synthesis system so that manipulations and calculations it carries out during the synthesis process are annotated with information on what the manipulations and calculations were and why they were made. This information is then accumulated throughout the synthesis process, at the end of which, every artifact produced by the synthesis is annotated with a complete history relating it to every other artifact (including the source specification) which influenced its construction. This approach requires modification of the entire synthesis system - which is labor-intensive and hard to do without influencing its behavior. In this paper, we introduce a novel, lightweight technique for deriving traceability from a program specification to the corresponding synthesized code. Once a program has been successfully synthesized from a specification, small changes are systematically made to the specification and the effects on the synthesized program observed. We have partially automated the technique and applied it in an experiment to one of our program synthesis systems, AUTOFILTER, and to the GNU C compiler, GCC. The results are promising: 1. Manual inspection of the results indicates that most of the connections derived from the source (a specification in the case of AUTOFILTER, C source code in the case of GCC) to its generated target (C source code in the case of AUTOFILTER, assembly language code in the case of GCC) are correct. 2. Around half of the lines in the target can be traced to at least one line of the source. 3. Small changes in the source often induce only small changes in the target.

Automating Traceability for Generated Software Artifacts

NASA Technical Reports Server (NTRS)

Richardson, Julian; Green, Jeffrey

2004-01-01

Program synthesis automatically derives programs from specifications of their behavior. One advantage of program synthesis, as opposed to manual coding, is that there is a direct link between the specification and the derived program. This link is, however, not very fine-grained: it can be best characterized as Program is-derived- from Specification. When the generated program needs to be understood or modified, more $ne-grained linking is useful. In this paper, we present a novel technique for automatically deriving traceability relations between parts of a specification and parts of the synthesized program. The technique is very lightweight and works -- with varying degrees of success - for any process in which one artifact is automatically derived from another. We illustrate the generality of the technique by applying it to two kinds of automatic generation: synthesis of Kalman Filter programs from speci3cations using the Aut- oFilter program synthesis system, and generation of assembly language programs from C source code using the GCC C compilel: We evaluate the effectiveness of the technique in the latter application.

Quality-assurance plan for water-resources activities of the U.S. Geological Survey in Idaho

USGS Publications Warehouse

Packard, F.A.

1996-01-01

To ensure continued confidence in its products, the Water Resources Division of the U.S. Geological Survey implemented a policy that all its scientific work be performed in accordance with a centrally managed quality-assurance program. This report establishes and documents a formal policy for current (1995) quality assurance within the Idaho District of the U.S. Geological Survey. Quality assurance is formalized by describing district organization and operational responsibilities, documenting the district quality-assurance policies, and describing district functions. The districts conducts its work through offices in Boise, Idaho Falls, Twin Falls, Sandpoint, and at the Idaho National Engineering Laboratory. Data-collection programs and interpretive studies are conducted by two operating units, and operational and technical assistance is provided by three support units: (1) Administrative Services advisors provide guidance on various personnel issues and budget functions, (2) computer and reports advisors provide guidance in their fields, and (3) discipline specialists provide technical advice and assistance to the district and to chiefs of various projects. The district's quality-assurance plan is based on an overall policy that provides a framework for defining the precision and accuracy of collected data. The plan is supported by a series of quality-assurance policy statements that describe responsibilities for specific operations in the district's program. The operations are program planning; project planning; project implementation; review and remediation; data collection; equipment calibration and maintenance; data processing and storage; data analysis, synthesis, and interpretation; report preparation and processing; and training. Activities of the district are systematically conducted under a hierarchy of supervision an management that is designed to ensure conformance with Water Resources Division goals quality assurance. The district quality-assurance plan does not describe detailed technical activities that are commonly termed "quality-control procedures." Instead, it focuses on current policies, operations, and responsibilities that are implemented at the management level. Contents of the plan will be reviewed annually and updated as programs and operations change.

Stereodivergent synthesis with a programmable molecular machine

NASA Astrophysics Data System (ADS)

Kassem, Salma; Lee, Alan T. L.; Leigh, David A.; Marcos, Vanesa; Palmer, Leoni I.; Pisano, Simone

2017-09-01

It has been convincingly argued that molecular machines that manipulate individual atoms, or highly reactive clusters of atoms, with Ångström precision are unlikely to be realized. However, biological molecular machines routinely position rather less reactive substrates in order to direct chemical reaction sequences, from sequence-specific synthesis by the ribosome to polyketide synthases, where tethered molecules are passed from active site to active site in multi-enzyme complexes. Artificial molecular machines have been developed for tasks that include sequence-specific oligomer synthesis and the switching of product chirality, a photo-responsive host molecule has been described that is able to mechanically twist a bound molecular guest, and molecular fragments have been selectively transported in either direction between sites on a molecular platform through a ratchet mechanism. Here we detail an artificial molecular machine that moves a substrate between different activating sites to achieve different product outcomes from chemical synthesis. This molecular robot can be programmed to stereoselectively produce, in a sequential one-pot operation, an excess of any one of four possible diastereoisomers from the addition of a thiol and an alkene to an α,β-unsaturated aldehyde in a tandem reaction process. The stereodivergent synthesis includes diastereoisomers that cannot be selectively synthesized through conventional iminium-enamine organocatalysis. We anticipate that future generations of programmable molecular machines may have significant roles in chemical synthesis and molecular manufacturing.

Object extraction method for image synthesis

NASA Astrophysics Data System (ADS)

Inoue, Seiki

1991-11-01

The extraction of component objects from images is fundamentally important for image synthesis. In TV program production, one useful method is the Video-Matte technique for specifying the necessary boundary of an object. This, however, involves some manually intricate and tedious processes. A new method proposed in this paper can reduce the needed level of operator skill and simplify object extraction. The object is automatically extracted by just a simple drawing of a thick boundary line. The basic principle involves a thinning of the thick boundary line binary image using the edge intensity of the original image. This method has many practical advantages, including the simplicity of specifying an object, the high accuracy of thinned-out boundary line, its ease of application to moving images, and the lack of any need for adjustment.

The Role of Ontologies in Schema-based Program Synthesis

NASA Technical Reports Server (NTRS)

Bures, Tomas; Denney, Ewen; Fischer, Bernd; Nistor, Eugen C.

2004-01-01

Program synthesis is the process of automatically deriving executable code from (non-executable) high-level specifications. It is more flexible and powerful than conventional code generation techniques that simply translate algorithmic specifications into lower-level code or only create code skeletons from structural specifications (such as UML class diagrams). Key to building a successful synthesis system is specializing to an appropriate application domain. The AUTOBAYES and AUTOFILTER systems, under development at NASA Ames, operate in the two domains of data analysis and state estimation, respectively. The central concept of both systems is the schema, a representation of reusable computational knowledge. This can take various forms, including high-level algorithm templates, code optimizations, datatype refinements, or architectural information. A schema also contains applicability conditions that are used to determine when it can be applied safely. These conditions can refer to the initial specification, to intermediate results, or to elements of the partially-instantiated code. Schema-based synthesis uses AI technology to recursively apply schemas to gradually refine a specification into executable code. This process proceeds in two main phases. A front-end gradually transforms the problem specification into a program represented in an abstract intermediate code. A backend then compiles this further down into a concrete target programming language of choice. A core engine applies schemas on the initial problem specification, then uses the output of those schemas as the input for other schemas, until the full implementation is generated. Since there might be different schemas that implement different solutions to the same problem this process can generate an entire solution tree. AUTOBAYES and AUTOFILTER have reached the level of maturity where they enable users to solve interesting application problems, e.g., the analysis of Hubble Space Telescope images. They are large (in total around 100kLoC Prolog), knowledge intensive systems that employ complex symbolic reasoning to generate a wide range of non-trivial programs for complex application do- mains. Their schemas can have complex interactions, which make it hard to change them in isolation or even understand what an existing schema actually does. Adding more capabilities by increasing the number of schemas will only worsen this situation, ultimately leading to the entropy death of the synthesis system. The root came of this problem is that the domain knowledge is scattered throughout the entire system and only represented implicitly in the schema implementations. In our current work, we are addressing this problem by making explicit the knowledge from Merent parts of the synthesis system. Here; we discuss how Gruber's definition of an ontology as an explicit specification of a conceptualization matches our efforts in identifying and explicating the domain-specific concepts. We outline the dual role ontologies play in schema-based synthesis and argue that they address different audiences and serve different purposes. Their first role is descriptive: they serve as explicit documentation, and help to understand the internal structure of the system. Their second role is prescriptive: they provide the formal basis against which the other parts of the system (e.g., schemas) can be checked. Their final role is referential: ontologies also provide semantically meaningful "hooks" which allow schemas and tools to access the internal state of the program derivation process (e.g., fragments of the generated code) in domain-specific rather than language-specific terms, and thus to modify it in a controlled fashion. For discussion purposes we use AUTOLINEAR, a small synthesis system we are currently experimenting with, which can generate code for solving a system of linear equations, Az = b.

Commercial-scale demonstration of the Liquid Phase Methanol process. Technical progress report number 8, April 1--June 30, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-12-31

The project involves the construction of an 80,000 gallon per day (260 tons per day (TPD)) methanol unit utilizing coal-derived synthesis gas from Eastman`s integrated coal gasification facility. The new equipment consists of synthesis gas feed preparation and compression facilities, the liquid phase reactor and auxiliaries, product distillation facilities, and utilities. The technology to be demonstrated is the product of a cooperative development effort by Air Products and DOE in a program that started in 1981. Developed to enhance electric power generation using integrated gasification combined cycle (IGCC) technology, the LPMEOH{trademark} process is ideally suited for directly processing gases producedmore » by modern-day coal gasifiers. Originally tested at a small (10 TPD), DOE-owned experimental unit in LaPorte, Texas, the technology provides several improvements essential for the economic coproduction of methanol and electricity directly from gasified coal. This liquid phase process suspends fine catalyst particles in an inert liquid, forming a slurry. The slurry dissipates the heat of the chemical reaction away from the catalyst surface, protecting the catalyst and allowing the methanol synthesis reaction to proceed at higher rates. At the Eastman complex, the technology is being integrated with existing coal-gasifiers. A carefully developed test plan will allow operations at Eastman to simulate electricity demand load-following in coal-based IGCC facilities. The operations will also demonstrate the enhanced stability and heat dissipation of the conversion process, its reliable on/off operation, and its ability to produce methanol as a clean liquid fuel without additional upgrading.« less

In Situ Observation of Directed Nanoparticle Aggregation During the Synthesis of Ordered Nanoporous Metal in Soft Templates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parent, Lucas R.; Robinson, David B.; Cappillino, Patrick J.

2014-02-11

The prevalent approach to developing new nanomaterials is a trial and error process of iteratively altering synthesis procedures and then characterizing the resulting nanostructures. This is fundamentally limited in that the growth processes that occur during synthesis can only be inferred from the final synthetic structure. Directly observing real-time nanomaterial growth provides unprecedented insight into the relationship between synthesis conditions and product evolution, and facilitates a mechanistic approach to nanomaterial development. Here we use in situ liquid stage scanning transmission electron microscopy to observe the growth of mesoporous palladium in a solvated block copolymer (BCP) template under various synthesis conditions,more » and ultimately determine a refined synthesis procedure that yields ordered pores. We find that at low organic solvent (tetrahydrofuran, THF) content, the BCP assembles into a rigid, cylindrical micelle array with a high degree of short-range order, but poor long-range order. Upon slowing the THF evaporation rate using a solvent-vapor anneal step, the long-range order is greatly improved. The electron beam induces nucleation of small particles in the aqueous phase around the micelles. The small particles then flocculate and grow into denser structures that surround the micelles, forming an ordered mesoporous structure. The microscope observations revealed that template disorder can be addressed prior to reaction, and is not invariably induced by the growth process itself, allowing us to more quickly optimize the synthetic method. This work was conducted in the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by DOE’s Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory. The Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy under contract DE-AC05-76RL01830. This research was funded in part by: the Presidential Early Career Award for Scientist and Engineers for I.A., the University of California Academic Senate and the University of California Laboratory fee research grant, the Laboratory-Directed Research and Development program at Sandia National Laboratories, and the Chemical Imaging Initiative at Pacific Northwest National Laboratory. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.« less

A synthesis of the "state-of-the-practice for advancing planning and operations integration opportunities within transportation agencies".

DOT National Transportation Integrated Search

2014-12-01

Linking Planning and Operations is vital to improving transportation decision-making and overall : efficiency of transportation systems management. This synthesis summarizes current state of : knowledge and practices in Planning and Operations Integr...

Assessment of protein synthesis in highly aerobic canine species at the onset and during exercise training.

PubMed

Miller, Benjamin F; Ehrlicher, Sarah E; Drake, Joshua C; Peelor, Frederick F; Biela, Laurie M; Pratt-Phillips, Shannon; Davis, Michael; Hamilton, Karyn L

2015-04-01

Canis lupus familiaris, the domesticated dog, is capable of extreme endurance performance. The ability to perform sustained aerobic exercise is dependent on a well-developed mitochondrial reticulum. In this study we examined the cumulative muscle protein and DNA synthesis in groups of athletic dogs at the onset of an exercise training program and following a strenuous exercise training program. We hypothesized that both at the onset and during an exercise training program there would be greater mitochondrial protein synthesis rates compared with sedentary control with no difference in mixed or cytoplasmic protein synthesis rates. Protein synthetic rates of three protein fractions and DNA synthesis were determined over 1 wk using (2)H2O in competitive Alaskan Huskies and Labrador Retrievers trained for explosive device detection. Both groups of dogs had very high rates of skeletal muscle protein synthesis in the sedentary state [Alaskan Huskies: Mixed = 2.28 ± 0.12, cytoplasmic (Cyto) = 2.91 ± 0.10, and mitochondrial (Mito) = 2.62 ± 0.07; Labrador Retrievers: Mixed = 3.88 ± 0.37, Cyto = 3.85 ± 0.06, and Mito = 2.92 ± 0.20%/day]. Mitochondrial (Mito) protein synthesis rates did not increase at the onset of an exercise training program. Exercise-trained dogs maintained Mito protein synthesis during exercise training when mixed (Mixed) and cytosolic (Cyto) fractions decreased, and this coincided with a decrease in p-RpS6 but also a decrease in p-ACC signaling. Contrary to our hypothesis, canines did not have large increases in mitochondrial protein synthesis at the onset or during an exercise training program. However, dogs have a high rate of protein synthesis compared with humans that perhaps does not necessitate an extra increase in protein synthesis at the onset of aerobic exercise training. Copyright © 2015 the American Physiological Society.

Combining Model-driven and Schema-based Program Synthesis

NASA Technical Reports Server (NTRS)

Denney, Ewen; Whittle, John

2004-01-01

We describe ongoing work which aims to extend the schema-based program synthesis paradigm with explicit models. In this context, schemas can be considered as model-to-model transformations. The combination of schemas with explicit models offers a number of advantages, namely, that building synthesis systems becomes much easier since the models can be used in verification and in adaptation of the synthesis systems. We illustrate our approach using an example from signal processing.

Auralization Architectures for NASA?s Next Generation Aircraft Noise Prediction Program

NASA Technical Reports Server (NTRS)

Rizzi, Stephen A.; Lopes, Leonard V.; Burley, Casey L.; Aumann, Aric R.

2013-01-01

Aircraft community noise is a significant concern due to continued growth in air traffic, increasingly stringent environmental goals, and operational limitations imposed by airport authorities. The assessment of human response to noise from future aircraft can only be afforded through laboratory testing using simulated flyover noise. Recent work by the authors demonstrated the ability to auralize predicted flyover noise for a state-of-the-art reference aircraft and a future hybrid wing body aircraft concept. This auralization used source noise predictions from NASA's Aircraft NOise Prediction Program (ANOPP) as input. The results from this process demonstrated that auralization based upon system noise predictions is consistent with, and complementary to, system noise predictions alone. To further develop and validate the auralization process, improvements to the interfaces between the synthesis capability and the system noise tools are required. This paper describes the key elements required for accurate noise synthesis and introduces auralization architectures for use with the next-generation ANOPP (ANOPP2). The architectures are built around a new auralization library and its associated Application Programming Interface (API) that utilize ANOPP2 APIs to access data required for auralization. The architectures are designed to make the process of auralizing flyover noise a common element of system noise prediction.

Determining the microwave coupling and operational efficiencies of a microwave plasma assisted chemical vapor deposition reactor under high pressure diamond synthesis operating conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nad, Shreya; Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824; Gu, Yajun

2015-07-15

The microwave coupling efficiency of the 2.45 GHz, microwave plasma assisted diamond synthesis process is investigated by experimentally measuring the performance of a specific single mode excited, internally tuned microwave plasma reactor. Plasma reactor coupling efficiencies (η) > 90% are achieved over the entire 100–260 Torr pressure range and 1.5–2.4 kW input power diamond synthesis regime. When operating at a specific experimental operating condition, small additional internal tuning adjustments can be made to achieve η > 98%. When the plasma reactor has low empty cavity losses, i.e., the empty cavity quality factor is >1500, then overall microwave discharge coupling efficienciesmore » (η{sub coup}) of >94% can be achieved. A large, safe, and efficient experimental operating regime is identified. Both substrate hot spots and the formation of microwave plasmoids are eliminated when operating within this regime. This investigation suggests that both the reactor design and the reactor process operation must be considered when attempting to lower diamond synthesis electrical energy costs while still enabling a very versatile and flexible operation performance.« less

Mathematical programming formulations for satellite synthesis

NASA Technical Reports Server (NTRS)

Bhasin, Puneet; Reilly, Charles H.

1987-01-01

The problem of satellite synthesis can be described as optimally allotting locations and sometimes frequencies and polarizations, to communication satellites so that interference from unwanted satellite signals does not exceed a specified threshold. In this report, mathematical programming models and optimization methods are used to solve satellite synthesis problems. A nonlinear programming formulation which is solved using Zoutendijk's method and a gradient search method is described. Nine mixed integer programming models are considered. Results of computer runs with these nine models and five geographically compatible scenarios are presented and evaluated. A heuristic solution procedure is also used to solve two of the models studied. Heuristic solutions to three large synthesis problems are presented. The results of our analysis show that the heuristic performs very well, both in terms of solution quality and solution time, on the two models to which it was applied. It is concluded that the heuristic procedure is the best of the methods considered for solving satellite synthesis problems.

SUMMARY OF EMISSIONS MANAGEMENT STRATEGY POLICY RELEVANT FINDINGS FROM EPA'S PM SUPERSITES PROGRAM

EPA Science Inventory

EPA is developing an integrated synthesis of key scientific and policy-relevant findings from EPA's Particulate Matter Supersites Program. This presentation provides a summary of the program and the integrated synthesis. Since there are many examples of such findings, ranging f...

Night-time road construction operations synthesis of practice.

DOT National Transportation Integrated Search

2008-05-01

report synthesizes existing literature on nighttime construction operations, identifies gaps in the current state of knowledge, and summarizes research in progress studies that are planned or underway. The literature review and synthesis found the fo...

Design, Sustainable Synthesis, and Programmed Reactions of Templated N-Heteroaryl-Fused Vinyl Sultams.

PubMed

Laha, Joydev K; Sharma, Shubhra; Kirar, Seema; Banerjee, Uttam C

2017-09-15

A de novo design and synthesis of N-heteroaryl-fused vinyl sultams as templates for programming chemical reactions on vinyl sultam periphery or (hetero)aryl ring is described. The key features include rational designing and sustainable synthesis of the template, customized reactions of vinyl sultams at C═C bond or involving N-S bond cleavage, and reactions on the periphery of the heteroaryl ring for late-stage diversification. The simple, easy access to the template coupled with opportunities for the synthesis of diversely functionalized heterocyles from a single template constitutes a rare study in contemporary organic synthesis.

Performance Analysis and Design Synthesis (PADS) computer program. Volume 2: Program description, part 1

NASA Technical Reports Server (NTRS)

1972-01-01

The Performance Analysis and Design Synthesis (PADS) computer program has a two-fold purpose. It can size launch vehicles in conjunction with calculus-of-variations optimal trajectories and can also be used as a general-purpose branched trajectory optimization program. In the former use, it has the Space Shuttle Synthesis Program as well as a simplified stage weight module for optimally sizing manned recoverable launch vehicles. For trajectory optimization alone or with sizing, PADS has two trajectory modules. The first trajectory module uses the method of steepest descent; the second employs the method of quasilinearization, which requires a starting solution from the first trajectory module. For Volume 1 see N73-13199.

Catalytic nucleic acids (DNAzymes) as functional units for logic gates and computing circuits: from basic principles to practical applications.

PubMed

Orbach, Ron; Willner, Bilha; Willner, Itamar

2015-03-11

This feature article addresses the implementation of catalytic nucleic acids as functional units for the construction of logic gates and computing circuits, and discusses the future applications of these systems. The assembly of computational modules composed of DNAzymes has led to the operation of a universal set of logic gates, to field programmable logic gates and computing circuits, to the development of multiplexers/demultiplexers, and to full-adder systems. Also, DNAzyme cascades operating as logic gates and computing circuits were demonstrated. DNAzyme logic systems find important practical applications. These include the use of DNAzyme-based systems for sensing and multiplexed analyses, for the development of controlled release and drug delivery systems, for regulating intracellular biosynthetic pathways, and for the programmed synthesis and operation of cascades.

A Flight Control System for Small Unmanned Aerial Vehicle

NASA Astrophysics Data System (ADS)

Tunik, A. A.; Nadsadnaya, O. I.

2018-03-01

The program adaptation of the controller for the flight control system (FCS) of an unmanned aerial vehicle (UAV) is considered. Linearized flight dynamic models depend mainly on the true airspeed of the UAV, which is measured by the onboard air data system. This enables its use for program adaptation of the FCS over the full range of altitudes and velocities, which define the flight operating range. FCS with program adaptation, based on static feedback (SF), is selected. The SF parameters for every sub-range of the true airspeed are determined using the linear matrix inequality approach in the case of discrete systems for synthesis of a suboptimal robust H ∞-controller. The use of the Lagrange interpolation between true airspeed sub-ranges provides continuous adaptation. The efficiency of the proposed approach is shown against an example of the heading stabilization system.

ACCESS 1: Approximation Concepts Code for Efficient Structural Synthesis program documentation and user's guide

NASA Technical Reports Server (NTRS)

Miura, H.; Schmit, L. A., Jr.

1976-01-01

The program documentation and user's guide for the ACCESS-1 computer program is presented. ACCESS-1 is a research oriented program which implements a collection of approximation concepts to achieve excellent efficiency in structural synthesis. The finite element method is used for structural analysis and general mathematical programming algorithms are applied in the design optimization procedure. Implementation of the computer program, preparation of input data and basic program structure are described, and three illustrative examples are given.

Hierarchical Synthesis of Coastal Ecosystem Health Indicators at Karimunjawa National Marine Park

NASA Astrophysics Data System (ADS)

Danu Prasetya, Johan; Ambariyanto; Supriharyono; Purwanti, Frida

2018-02-01

The coastal ecosystem of Karimunjawa National Marine Park (KNMP) is facing various pressures, including from human activity. Monitoring the health condition of coastal ecosystems periodically is needed as an evaluation of the ecosystem condition. Systematic and consistent indicators are needed in monitoring of coastal ecosystem health. This paper presents hierarchical synthesis of coastal ecosystem health indicators using Analytic Hierarchy Process (AHP) method. Hierarchical synthesis is obtained from process of weighting by paired comparison based on expert judgments. The variables of coastal ecosystem health indicators in this synthesis consist of 3 level of variable, i.e. main variable, sub-variable and operational variable. As a result of assessment, coastal ecosystem health indicators consist of 3 main variables, i.e. State of Ecosystem, Pressure and Management. Main variables State of Ecosystem and Management obtain the same value i.e. 0.400, while Pressure value was 0.200. Each main variable consist of several sub-variable, i.e. coral reef, reef fish, mangrove and seagrass for State of Ecosystem; fisheries and marine tourism activity for Pressure; planning and regulation, institutional and also infrastructure and financing for Management. The highest value of sub-variable of main variable State of Ecosystem, Pressure and Management were coral reef (0.186); marine tourism pressure (0.133) and institutional (0.171), respectively. The highest value of operational variable of main variable State of Ecosystem, Pressure and Management were percent of coral cover (0.058), marine tourism pressure (0.133) and presence of zonation plan, regulation also socialization of monitoring program (0.53), respectively. Potential pressure from marine tourism activity is the variable that most affect the health of the ecosystem. The results of this research suggest that there is a need to develop stronger conservation strategies to facing with pressures from marine tourism activities.

Music 4C, a multi-voiced synthesis program with instruments defined in C

NASA Astrophysics Data System (ADS)

Beauchamp, James W.

2003-04-01

Music 4C is a program which runs under Unix (including Linux) and provides a means for the synthesis of arbitrary signals as defined by the C code. The program is actually a loose translation of an earlier program, Music 4BF [H. S. Howe, Jr., Electronic Music Synthesis (Norton, 1975)]. A set of instrument definitions are driven by a numerical score which consists of a series of ``events.'' Each event gives an instrument name, start time and duration, and a number of parameters (e.g., pitch) which describe the event. Each instrument definition consists of event parameters, performance variables, initializations, and a synthesis algorithmic code. Thus, the synthetic signal, no matter how complex, is precisely defined. Moreover, the resulting sounds can be overlaid in any arbitrary pattern. The program serves as a mixer of algorithmically produced sounds or recorded sounds taken from sample files or synthesized from spectrum files. A score file can be entered by hand, generated from a program, translated from a MIDI file, or generated from an alpha-numeric score using an auxiliary program, Notepro. Output sample files are in wav, snd, or aiff format. The program is provided in the C source code for download.

Research on Molecular Sieve Technology.

ERIC Educational Resources Information Center

Shah, Dhananjai B.; Hayhurst, David T.

1985-01-01

The zeolite synthesis and modification research program at Cleveland State University (Ohio) is described, including program philosophy and objectives, and research facilities. Also considers zeolite synthesis, adsorption on zeolites, kinetics of adsorption, and zeolite catalysis research. (JN)

Applications for the environment : real-time information synthesis (AERIS). Eco-lanes : operational concept.

DOT National Transportation Integrated Search

2013-10-01

This document serves as an Operational Concept for the Applications for the Environment: Real-Time Information Synthesis (AERIS) Eco-Lanes Transformative Concept. The Eco-Lanes Transformative Concept features dedicated lanes on freeways optimized for...

Integration of a code for aeroelastic design of conventional and composite wings into ACSYNT, an aircraft synthesis program. [wing aeroelastic design (WADES)

NASA Technical Reports Server (NTRS)

Mullen, J., Jr.

1976-01-01

A comparison of program estimates of wing weight, material distribution. structural loads and elastic deformations with actual Northrop F-5A/B data is presented. Correlation coefficients obtained using data from a number of existing aircraft were computed for use in vehicle synthesis to estimate wing weights. The modifications necessary to adapt the WADES code for use in the ACSYNT program are described. Basic program flow and overlay structure is outlined. An example of the convergence of the procedure in estimating wing weights during the synthesis of a vehicle to satisfy F-5 mission requirements is given. A description of inputs required for use of the WADES program is included.

Flight Path Synthesis and HUD Scaling for V/STOL Terminal Area Operations

DOT National Transportation Integrated Search

1995-04-01

A two circle horizontal flightpath synthesis algorithm for Vertical/Short : Takeoff and Landing (V/STOL) terminal area operations is presented. This : algorithm provides a flight-path that is tangential to the aircraft's velocity : vector at the inst...

Applications for the environment : real-time information synthesis low emissions zones : operational concept.

DOT National Transportation Integrated Search

2013-10-01

This document serves as an Operational Concept for the Applications for the Environment: Real-Time Information Synthesis (AERIS) Low Emissions Zones Transformative Concept. The Low Emissions Zone Transformative Concept includes the ability for an ent...

Automatic programming for critical applications

NASA Technical Reports Server (NTRS)

Loganantharaj, Raj L.

1988-01-01

The important phases of a software life cycle include verification and maintenance. Usually, the execution performance is an expected requirement in a software development process. Unfortunately, the verification and the maintenance of programs are the time consuming and the frustrating aspects of software engineering. The verification cannot be waived for the programs used for critical applications such as, military, space, and nuclear plants. As a consequence, synthesis of programs from specifications, an alternative way of developing correct programs, is becoming popular. The definition, or what is understood by automatic programming, has been changed with our expectations. At present, the goal of automatic programming is the automation of programming process. Specifically, it means the application of artificial intelligence to software engineering in order to define techniques and create environments that help in the creation of high level programs. The automatic programming process may be divided into two phases: the problem acquisition phase and the program synthesis phase. In the problem acquisition phase, an informal specification of the problem is transformed into an unambiguous specification while in the program synthesis phase such a specification is further transformed into a concrete, executable program.

Improved scaling laws for stage inert mass space Propulsion systems. Volume 3: Propulsion synthesis program users and programmers manual

NASA Technical Reports Server (NTRS)

1971-01-01

The analytical models developed for the Space Propulsion Automated Synthesis Modeling (SPASM) program are presented. Weight scaling laws developed during this study are incorporated into the program's scaling data bank. A detail listing, logic diagram and input/output formats are supplied for the SPASM program. Two test examples for one to four-stage vehicles performing different types of missions are shown to demonstrate the program's capability and versatility.

An implementation of the distributed programming structural synthesis system (PROSSS)

NASA Technical Reports Server (NTRS)

Rogers, J. L., Jr.

1981-01-01

A method is described for implementing a flexible software system that combines large, complex programs with small, user-supplied, problem-dependent programs and that distributes their execution between a mainframe and a minicomputer. The Programming Structural Synthesis System (PROSSS) was the specific software system considered. The results of such distributed implementation are flexibility of the optimization procedure organization and versatility of the formulation of constraints and design variables.

Development of weight/sizing design synthesis computer program. Volume 3: User Manual

NASA Technical Reports Server (NTRS)

Garrison, J. M.

1973-01-01

The user manual for the weight/sizing design synthesis program is presented. The program is applied to an analysis of the basic weight relationships for the space shuttle which contribute significant portions of the inert weight. The relationships measure the parameters of load, geometry, material, and environment. A verbal description of the processes simulated, data input procedures, output data, and values present in the program is included.

Feasibility study of a synthesis procedure for array feeds to improve radiation performance of large distorted reflector antennas

NASA Technical Reports Server (NTRS)

Stutzman, W. L.; Takamizawa, K.; Werntz, P.; Lapean, J.; Barts, R.

1991-01-01

The following subject areas are covered: General Reflector Antenna Systems Program version 7(GRASP7); Multiple Reflector Analysis Program for Cylindrical Antennas (MRAPCA); Tri-Reflector 2D Synthesis Code (TRTDS); a geometrical optics and a physical optics synthesis techniques; beam scanning reflector, the type 2 and 6 reflectors, spherical reflector, and multiple reflector imaging systems; and radiometric array design.

Transonic transport study: Economics

NASA Technical Reports Server (NTRS)

Smith, C. L.; Wilcox, D. E.

1972-01-01

An economic analysis was performed to evaluate the impact of advanced materials, increased aerodynamic and structural efficiencies, and cruise speed on advanced transport aircraft designed for cruise Mach numbers of .90, .98, and 1.15. A detailed weight statement was generated by an aircraft synthesis computer program called TRANSYN-TST; these weights were used to estimate the cost to develop and manufacture a fleet of aircraft of each configuration. The direct and indirect operating costs were estimated for each aircraft, and an average return on investment was calculated for various operating conditions. There was very little difference between the operating economics of the aircraft designed for Mach numbers .90 and .98. The Mach number 1.15 aircraft was economically marginal in comparison but showed significant improvements with the application of carbon/epoxy structural material. However, the Mach .90 and Mach .98 aircraft are the most economically attractive vehicles in the study.

The Center for Nanophase Materials Sciences

NASA Astrophysics Data System (ADS)

Lowndes, Douglas

2005-03-01

The Center for Nanophase Materials Sciences (CNMS) located at Oak Ridge National Laboratory (ORNL) will be the first DOE Nanoscale Science Research Center to begin operation, with construction to be completed in April 2005 and initial operations in October 2005. The CNMS' scientific program has been developed through workshops with the national community, with the goal of creating a highly collaborative research environment to accelerate discovery and drive technological advances. Research at the CNMS is organized under seven Scientific Themes selected to address challenges to understanding and to exploit particular ORNL strengths (see http://cnms.ornl.govhttp://cnms.ornl.gov). These include extensive synthesis and characterization capabilities for soft, hard, nanostructured, magnetic and catalytic materials and their composites; neutron scattering at the Spallation Neutron Source and High Flux Isotope Reactor; computational nanoscience in the CNMS' Nanomaterials Theory Institute and utilizing facilities and expertise of the Center for Computational Sciences and the new Leadership Scientific Computing Facility at ORNL; a new CNMS Nanofabrication Research Laboratory; and a suite of unique and state-of-the-art instruments to be made reliably available to the national community for imaging, manipulation, and properties measurements on nanoscale materials in controlled environments. The new research facilities will be described together with the planned operation of the user research program, the latter illustrated by the current ``jump start'' user program that utilizes existing ORNL/CNMS facilities.

Process synthesis involving multi-period operations by the P-graph framework

EPA Science Inventory

The P-graph (process graph) framework is an effective tool for process-network synthesis (PNS). Here we extended it to multi-period operations. The efficacy of the P-graph methodology has been demonstrated by numerous applications. The unambiguous representation of processes and ...

Analysis and synthesis of abstract data types through generalization from examples

NASA Technical Reports Server (NTRS)

Wild, Christian

1987-01-01

The discovery of general patterns of behavior from a set of input/output examples can be a useful technique in the automated analysis and synthesis of software systems. These generalized descriptions of the behavior form a set of assertions which can be used for validation, program synthesis, program testing and run-time monitoring. Describing the behavior is characterized as a learning process in which general patterns can be easily characterized. The learning algorithm must choose a transform function and define a subset of the transform space which is related to equivalence classes of behavior in the original domain. An algorithm for analyzing the behavior of abstract data types is presented and several examples are given. The use of the analysis for purposes of program synthesis is also discussed.

Lunar Transportation Facilities and Operations Study, option 2

NASA Technical Reports Server (NTRS)

1992-01-01

During the Option 2 period of the Lunar Transportation Facilities and Operations Study (LTFOS), a joint McDonnell Douglas Space Systems Company Kennedy Space Center (MDSSC-KSC) and National Aeronautics and Space Administration Kennedy Space Center (NASA-KSC) Study team conducted a comparison of the functional testing of the RL-10 and Space Shuttle Main Engine, a quick-look impact assessment of the Synthesis Group Report, and a detailed assessment of the Synthesis Group Report. The results of these KSC LTFOS team efforts are included. The most recent study task effort was a detailed assessment of the Synthesis Group Report. The assessment was conducted to determine the impact on planetary launch and landing facilities and operations. The result of that effort is a report entitled 'Analysis of the Synthesis Group Report, its Architectures and their Impacts on PSS Launch and Landing Operations' and is contained in Appendix A. The report is structured in a briefing format with facing pages as opposed to a narrative style. A quick-look assessment of the Synthesis Group Report was conducted to determine the impact of implementing the recommendations of the Synthesis Group on KSC launch facilities and operations. The data was documented in a presentation format as requested by Kennedy Space Center Technology and Advanced Projects Office and is included in Appendix B. Appendix C is a white paper on the comparison of the functional testing of the RL-10 and Space Shuttle Main Engine. The comparison was undertaken to provide insight regarding common test requirements that would be applicable to Lunar and Mars Excursion Vehicles (LEV and MEV).

A Program in Air Transportation Technology (Joint University Program)

NASA Technical Reports Server (NTRS)

Stengel, Robert F.

1996-01-01

The Joint University Program on Air Transportation Technology was conducted at Princeton University from 1971 to 1995. Our vision was to further understanding of the design and operation of transport aircraft, of the effects of atmospheric environment on aircraft flight, and of the development and utilization of the National Airspace System. As an adjunct, the program emphasized the independent research of both graduate and undergraduate students. Recent principal goals were to develop and verify new methods for design and analysis of intelligent flight control systems, aircraft guidance logic for recovery from wake vortex encounter, and robust flight control systems. Our research scope subsumed problems associated with multidisciplinary aircraft design synthesis and analysis based on flight physics, providing a theoretical basis for developing innovative control concepts that enhance aircraft performance and safety. Our research focus was of direct interest not only to NASA but to manufacturers of aircraft and their associated systems. Our approach, metrics, and future directions described in the remainder of the report.

Toward synthesizing executable models in biology.

PubMed

Fisher, Jasmin; Piterman, Nir; Bodik, Rastislav

2014-01-01

Over the last decade, executable models of biological behaviors have repeatedly provided new scientific discoveries, uncovered novel insights, and directed new experimental avenues. These models are computer programs whose execution mechanistically simulates aspects of the cell's behaviors. If the observed behavior of the program agrees with the observed biological behavior, then the program explains the phenomena. This approach has proven beneficial for gaining new biological insights and directing new experimental avenues. One advantage of this approach is that techniques for analysis of computer programs can be applied to the analysis of executable models. For example, one can confirm that a model agrees with experiments for all possible executions of the model (corresponding to all environmental conditions), even if there are a huge number of executions. Various formal methods have been adapted for this context, for example, model checking or symbolic analysis of state spaces. To avoid manual construction of executable models, one can apply synthesis, a method to produce programs automatically from high-level specifications. In the context of biological modeling, synthesis would correspond to extracting executable models from experimental data. We survey recent results about the usage of the techniques underlying synthesis of computer programs for the inference of biological models from experimental data. We describe synthesis of biological models from curated mutation experiment data, inferring network connectivity models from phosphoproteomic data, and synthesis of Boolean networks from gene expression data. While much work has been done on automated analysis of similar datasets using machine learning and artificial intelligence, using synthesis techniques provides new opportunities such as efficient computation of disambiguating experiments, as well as the ability to produce different kinds of models automatically from biological data.

Approximation concepts for efficient structural synthesis

NASA Technical Reports Server (NTRS)

Schmit, L. A., Jr.; Miura, H.

1976-01-01

It is shown that efficient structural synthesis capabilities can be created by using approximation concepts to mesh finite element structural analysis methods with nonlinear mathematical programming techniques. The history of the application of mathematical programming techniques to structural design optimization problems is reviewed. Several rather general approximation concepts are described along with the technical foundations of the ACCESS 1 computer program, which implements several approximation concepts. A substantial collection of structural design problems involving truss and idealized wing structures is presented. It is concluded that since the basic ideas employed in creating the ACCESS 1 program are rather general, its successful development supports the contention that the introduction of approximation concepts will lead to the emergence of a new generation of practical and efficient, large scale, structural synthesis capabilities in which finite element analysis methods and mathematical programming algorithms will play a central role.

Interactive evolution of camouflage.

PubMed

Reynolds, Craig

2011-01-01

This article presents an abstract computation model of the evolution of camouflage in nature. The 2D model uses evolved textures for prey, a background texture representing the environment, and a visual predator. A human observer, acting as the predator, is shown a cohort of 10 evolved textures overlaid on the background texture. The observer clicks on the five most conspicuous prey to remove ("eat") them. These lower-fitness textures are removed from the population and replaced with newly bred textures. Biological morphogenesis is represented in this model by procedural texture synthesis. Nested expressions of generators and operators form a texture description language. Natural evolution is represented by genetic programming (GP), a variant of the genetic algorithm. GP searches the space of texture description programs for those that appear least conspicuous to the predator.

Data synthesis and display programs for wave distribution function analysis

NASA Technical Reports Server (NTRS)

Storey, L. R. O.; Yeh, K. J.

1992-01-01

At the National Space Science Data Center (NSSDC) software was written to synthesize and display artificial data for use in developing the methodology of wave distribution analysis. The software comprises two separate interactive programs, one for data synthesis and the other for data display.

Flexible Generation of Kalman Filter Code

NASA Technical Reports Server (NTRS)

Richardson, Julian; Wilson, Edward

2006-01-01

Domain-specific program synthesis can automatically generate high quality code in complex domains from succinct specifications, but the range of programs which can be generated by a given synthesis system is typically narrow. Obtaining code which falls outside this narrow scope necessitates either 1) extension of the code generator, which is usually very expensive, or 2) manual modification of the generated code, which is often difficult and which must be redone whenever changes are made to the program specification. In this paper, we describe adaptations and extensions of the AUTOFILTER Kalman filter synthesis system which greatly extend the range of programs which can be generated. Users augment the input specification with a specification of code fragments and how those fragments should interleave with or replace parts of the synthesized filter. This allows users to generate a much wider range of programs without their needing to modify the synthesis system or edit generated code. We demonstrate the usefulness of the approach by applying it to the synthesis of a complex state estimator which combines code from several Kalman filters with user-specified code. The work described in this paper allows the complex design decisions necessary for real-world applications to be reflected in the synthesized code. When executed on simulated input data, the generated state estimator was found to produce comparable estimates to those produced by a handcoded estimator

Reuse: A knowledge-based approach

NASA Technical Reports Server (NTRS)

Iscoe, Neil; Liu, Zheng-Yang; Feng, Guohui

1992-01-01

This paper describes our research in automating the reuse process through the use of application domain models. Application domain models are explicit formal representations of the application knowledge necessary to understand, specify, and generate application programs. Furthermore, they provide a unified repository for the operational structure, rules, policies, and constraints of a specific application area. In our approach, domain models are expressed in terms of a transaction-based meta-modeling language. This paper has described in detail the creation and maintenance of hierarchical structures. These structures are created through a process that includes reverse engineering of data models with supplementary enhancement from application experts. Source code is also reverse engineered but is not a major source of domain model instantiation at this time. In the second phase of the software synthesis process, program specifications are interactively synthesized from an instantiated domain model. These specifications are currently integrated into a manual programming process but will eventually be used to derive executable code with mechanically assisted transformations. This research is performed within the context of programming-in-the-large types of systems. Although our goals are ambitious, we are implementing the synthesis system in an incremental manner through which we can realize tangible results. The client/server architecture is capable of supporting 16 simultaneous X/Motif users and tens of thousands of attributes and classes. Domain models have been partially synthesized from five different application areas. As additional domain models are synthesized and additional knowledge is gathered, we will inevitably add to and modify our representation. However, our current experience indicates that it will scale and expand to meet our modeling needs.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, B.E.; Ahner, P.F.; Singelton, A.H.

In situ gasification of steeply dipping coal beds (UCG-SDB) has significant advantages over the more conventional horizontal UCG. In fact, the UCG-SDB process appears to be both technically and operationally competitive with surface gasifiers. The results of the Rawlins UCG-SDB field test program suggest that the process can compete with more conventional sources of synthesis gas on an economic basis. The SDB process mechanism has several advantages over the horizontal process and performs in a fashion similar to surface packedbed reactors. The oxygen requirements for the process are quite low and the degree of process control observed at Rawlins ismore » very attractive.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, B.E.; Ahner, P.F.

In-situ gasification of steeply dipping coal beds (UCG-SDB) has significant advantages over the more conventional horizontal UCG. In fact, the UCG-SDB process appears to be both technically and operationally competitive with surface gasifiers. The results of the Rawlins UCG-SDB field test program suggest that the process can compete with more conventional sources of synthesis gas on an economic basis. The SDB process mechanism has several advantages over the horizontal process and performs in a fashion similar to surface packed bed reactors. The oxygen requirements for the process are quite low and the degree of process control observed at Rawlins ismore » very attractive.« less

The digital code driven autonomous synthesis of ibuprofen automated in a 3D-printer-based robot.

PubMed

Kitson, Philip J; Glatzel, Stefan; Cronin, Leroy

2016-01-01

An automated synthesis robot was constructed by modifying an open source 3D printing platform. The resulting automated system was used to 3D print reaction vessels (reactionware) of differing internal volumes using polypropylene feedstock via a fused deposition modeling 3D printing approach and subsequently make use of these fabricated vessels to synthesize the nonsteroidal anti-inflammatory drug ibuprofen via a consecutive one-pot three-step approach. The synthesis of ibuprofen could be achieved on different scales simply by adjusting the parameters in the robot control software. The software for controlling the synthesis robot was written in the python programming language and hard-coded for the synthesis of ibuprofen by the method described, opening possibilities for the sharing of validated synthetic 'programs' which can run on similar low cost, user-constructed robotic platforms towards an 'open-source' regime in the area of chemical synthesis.

Teaching Heat Exchanger Network Synthesis Using Interactive Microcomputer Graphics.

ERIC Educational Resources Information Center

Dixon, Anthony G.

1987-01-01

Describes the Heat Exchanger Network Synthesis (HENS) program used at Worcester Polytechnic Institute (Massachusetts) as an aid to teaching the energy integration step in process design. Focuses on the benefits of the computer graphics used in the program to increase the speed of generating and changing networks. (TW)

A High-Throughput Screening Assay to Detect Thyroperoxidase Inhibitors (Teratology Society)

EPA Science Inventory

In support of the Endocrine Disruption Screening Program (EDSP21), the US EPA ToxCast program is developing assays to enable screening for chemicals that may disrupt thyroid hormone synthesis. Thyroperoxidase (TPO) is critical for TH synthesis and is a known target of thyroid-dis...

ISSYS: An integrated synergistic Synthesis System

NASA Technical Reports Server (NTRS)

Dovi, A. R.

1980-01-01

Integrated Synergistic Synthesis System (ISSYS), an integrated system of computer codes in which the sequence of program execution and data flow is controlled by the user, is discussed. The commands available to exert such control, the ISSYS major function and rules, and the computer codes currently available in the system are described. Computational sequences frequently used in the aircraft structural analysis and synthesis are defined. External computer codes utilized by the ISSYS system are documented. A bibliography on the programs is included.

Synthesis of Virtual Environments for Aircraft Community Noise Impact Studies

NASA Technical Reports Server (NTRS)

Rizzi, Stephen A.; Sullivan, Brenda M.

2005-01-01

A new capability has been developed for the creation of virtual environments for the study of aircraft community noise. It is applicable for use with both recorded and synthesized aircraft noise. When using synthesized noise, a three-stage process is adopted involving non-real-time prediction and synthesis stages followed by a real-time rendering stage. Included in the prediction-based source noise synthesis are temporal variations associated with changes in operational state, and low frequency fluctuations that are present under all operating conditions. Included in the rendering stage are the effects of spreading loss, absolute delay, atmospheric absorption, ground reflections, and binaural filtering. Results of prediction, synthesis and rendering stages are presented.

Man-machine Integration Design and Analysis System (MIDAS) Task Loading Model (TLM) experimental and software detailed design report

NASA Technical Reports Server (NTRS)

Staveland, Lowell

1994-01-01

This is the experimental and software detailed design report for the prototype task loading model (TLM) developed as part of the man-machine integration design and analysis system (MIDAS), as implemented and tested in phase 6 of the Army-NASA Aircrew/Aircraft Integration (A3I) Program. The A3I program is an exploratory development effort to advance the capabilities and use of computational representations of human performance and behavior in the design, synthesis, and analysis of manned systems. The MIDAS TLM computationally models the demands designs impose on operators to aide engineers in the conceptual design of aircraft crewstations. This report describes TLM and the results of a series of experiments which were run this phase to test its capabilities as a predictive task demand modeling tool. Specifically, it includes discussions of: the inputs and outputs of TLM, the theories underlying it, the results of the test experiments, the use of the TLM as both stand alone tool and part of a complete human operator simulation, and a brief introduction to the TLM software design.

Analysis and synthesis of abstract data types through generalization from examples

NASA Technical Reports Server (NTRS)

Wild, Christian

1987-01-01

The discovery of general patterns of behavior from a set of input/output examples can be a useful technique in the automated analysis and synthesis of software systems. These generalized descriptions of the behavior form a set of assertions which can be used for validation, program synthesis, program testing, and run-time monitoring. Describing the behavior is characterized as a learning process in which the set of inputs is mapped into an appropriate transform space such that general patterns can be easily characterized. The learning algorithm must chose a transform function and define a subset of the transform space which is related to equivalence classes of behavior in the original domain. An algorithm for analyzing the behavior of abstract data types is presented and several examples are given. The use of the analysis for purposes of program synthesis is also discussed.

DOE Coal Gasification Multi-Test Facility: fossil fuel processing technical/professional services

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hefferan, J.K.; Lee, G.Y.; Boesch, L.P.

1979-07-13

A conceptual design, including process descriptions, heat and material balances, process flow diagrams, utility requirements, schedule, capital and operating cost estimate, and alternative design considerations, is presented for the DOE Coal Gasification Multi-Test Facility (GMTF). The GMTF, an engineering scale facility, is to provide a complete plant into which different types of gasifiers and conversion/synthesis equipment can be readily integrated for testing in an operational environment at relatively low cost. The design allows for operation of several gasifiers simultaneously at a total coal throughput of 2500 tons/day; individual gasifiers operate at up to 1200 tons/day and 600 psig using airmore » or oxygen. Ten different test gasifiers can be in place at the facility, but only three can be operated at one time. The GMTF can produce a spectrum of saleable products, including low Btu, synthesis and pipeline gases, hydrogen (for fuel cells or hydrogasification), methanol, gasoline, diesel and fuel oils, organic chemicals, and electrical power (potentially). In 1979 dollars, the base facility requires a $288 million capital investment for common-use units, $193 million for four gasification units and four synthesis units, and $305 million for six years of operation. Critical reviews of detailed vendor designs are appended for a methanol synthesis unit, three entrained flow gasifiers, a fluidized bed gasifier, and a hydrogasifier/slag-bath gasifier.« less

Performance Analysis and Design Synthesis (PADS) computer program. Volume 1: Formulation

NASA Technical Reports Server (NTRS)

1972-01-01

The program formulation for PADS computer program is presented. It can size launch vehicles in conjunction with calculus-of-variations optimal trajectories and can also be used as a general-purpose branched trajectory optimization program. In the former use, it has the Space Shuttle Synthesis Program as well as a simplified stage weight module for optimally sizing manned recoverable launch vehicles. For trajectory optimization alone or with sizing, PADS has two trajectory modules. The first trajectory module uses the method of steepest descent; the second employs the method of quasilinearization, which requires a starting solution from the first trajectory module.

Small Business Innovations

NASA Technical Reports Server (NTRS)

1993-01-01

Under an Army Small Business Innovation Research (SBIR) grant, Symbiotics, Inc. developed a software system that permits users to upgrade products from standalone applications so they can communicate in a distributed computing environment. Under a subsequent NASA SBIR grant, Symbiotics added additional tools to the SOCIAL product to enable NASA to coordinate conventional systems for planning Shuttle launch support operations. Using SOCIAL, data may be shared among applications in a computer network even when the applications are written in different programming languages. The product was introduced to the commercial market in 1993 and is used to monitor and control equipment for operation support and to integrate financial networks. The SBIR program was established to increase small business participation in federal R&D activities and to transfer government research to industry. InQuisiX is a reuse library providing high performance classification, cataloging, searching, browsing, retrieval and synthesis capabilities. These form the foundation for software reuse, producing higher quality software at lower cost and in less time. Software Productivity Solutions, Inc. developed the technology under Small Business Innovation Research (SBIR) projects funded by NASA and the Army and is marketing InQuisiX in conjunction with Science Applications International Corporation (SAIC). The SBIR program was established to increase small business participation in federal R&D activities and to transfer government research to industry.

Space Congress, 29th, Cocoa Beach, FL, Apr. 21-24, 1992, Proceedings

NASA Technical Reports Server (NTRS)

1992-01-01

The present volume on the quest for new frontiers in space discusses weather impacts on space operations, planning for the performance of future space bases, a new guidance and control unit for the Titan IV vehicle, and nondestructive evaluation of Shuttle Columbia tiles. Attention is given to Space Shuttle payload accommodations and trends in customer demands, a generic propellants transfer unit, making space part of general education, space station on-orbit solar array loads during assembly, and dimensional stability of the attitude reference assembly on SSF. Topics addressed include National Launch System payload accommodations and launch operations, the integrated factory/launch site processing concept, Pioneer 10 interstellar studies, and the role of advanced nuclear propulsion systems in precursor interstellar missions. Also discussed are legal challenges in realizing interstellar initiatives, Mars transportation system synthesis, and NASA's commercial space program.

Performance Analysis and Design Synthesis (PADS) computer program. Volume 3: User manual

NASA Technical Reports Server (NTRS)

1972-01-01

The two-fold purpose of the Performance Analysis and Design Synthesis (PADS) computer program is discussed. The program can size launch vehicles in conjunction with calculus-of-variations optimal trajectories and can also be used as a general purpose branched trajectory optimization program. For trajectory optimization alone or with sizing, PADS has two trajectory modules. The first trajectory module uses the method of steepest descent. The second module uses the method of quasi-linearization, which requires a starting solution from the first trajectory module.

A Mesopore-Dependent Catalytic Cracking of n-Hexane Over Mesoporous Nanostructured ZSM-5.

PubMed

Qamar, M; Ahmed, M I; Qamaruddin, M; Asif, M; Sanhoob, M; Muraza, O; Khan, M Y

2018-08-01

Herein, pore size, crystalinity, and Si/Al ratio of mesoporous ZSM-5 (MFI) nanocrystals was controlled by synthesis parameters, such as surfactant concentration ([3-(trimethoxysilyl)propyl] hexa-decyl dimethyl ammonium chloride), sodium hydroxide concentrations, synthesis temperature and time. The morphology, surface structure and composition of the MFI particles was systematically investigated. More notably, the mesopore-dependent catalytic activity of ZSM-5 was evaluated by studying the cracking of n-hexane. The findings suggest the porosity has pronounced impact on the catalytic activity, selectivity and stability of ZSM-5 nanocrystals. Critical surface attributes such as nature of acid sites (Brønsted and Lewis), concentration, and strength are obtained by the infrared study of adsorbed probe molecules (pyridine) and the temperature programmed desorption. In spite of being weaker in Si/Al ratio or acidic strength, mesoporous catalysts showed more stable and efficient cracking of n-hexane suggesting that acidity seems not the predominant factor operative in the activity, selectivity and stability.

Conducting quantitative synthesis when comparing medical interventions: AHRQ and the Effective Health Care Program.

PubMed

Fu, Rongwei; Gartlehner, Gerald; Grant, Mark; Shamliyan, Tatyana; Sedrakyan, Art; Wilt, Timothy J; Griffith, Lauren; Oremus, Mark; Raina, Parminder; Ismaila, Afisi; Santaguida, Pasqualina; Lau, Joseph; Trikalinos, Thomas A

2011-11-01

This article is to establish recommendations for conducting quantitative synthesis, or meta-analysis, using study-level data in comparative effectiveness reviews (CERs) for the Evidence-based Practice Center (EPC) program of the Agency for Healthcare Research and Quality. We focused on recurrent issues in the EPC program and the recommendations were developed using group discussion and consensus based on current knowledge in the literature. We first discussed considerations for deciding whether to combine studies, followed by discussions on indirect comparison and incorporation of indirect evidence. Then, we described our recommendations on choosing effect measures and statistical models, giving special attention to combining studies with rare events; and on testing and exploring heterogeneity. Finally, we briefly presented recommendations on combining studies of mixed design and on sensitivity analysis. Quantitative synthesis should be conducted in a transparent and consistent way. Inclusion of multiple alternative interventions in CERs increases the complexity of quantitative synthesis, whereas the basic issues in quantitative synthesis remain crucial considerations in quantitative synthesis for a CER. We will cover more issues in future versions and update and improve recommendations with the accumulation of new research to advance the goal for transparency and consistency. Copyright © 2011 Elsevier Inc. All rights reserved.

Real-time LMR control parameter generation using advanced adaptive synthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, R.W.; Mott, J.E.

1990-01-01

The reactor delta T'', the difference between the average core inlet and outlet temperatures, for the liquid-sodium-cooled Experimental Breeder Reactor 2 is empirically synthesized in real time from, a multitude of examples of past reactor operation. The real-time empirical synthesis is based on reactor operation. The real-time empirical synthesis is based on system state analysis (SSA) technology embodied in software on the EBR 2 data acquisition computer. Before the real-time system is put into operation, a selection of reactor plant measurements is made which is predictable over long periods encompassing plant shutdowns, core reconfigurations, core load changes, and plant startups.more » A serial data link to a personal computer containing SSA software allows the rapid verification of the predictability of these plant measurements via graphical means. After the selection is made, the real-time synthesis provides a fault-tolerant estimate of the reactor delta T accurate to {plus}/{minus}1{percent}. 5 refs., 7 figs.« less

Required technologies for a lunar optical UV-IR synthesis array

NASA Technical Reports Server (NTRS)

Johnson, Stewart W.; Wetzel, John P.

1992-01-01

A Lunar Optical UV-IR Synthesis Array (LOUISA) proposed to take advantage of the characteristics of the lunar environment requires appropriate advances in technology. These technologies are in the areas of contamination/interference control, test and evaluation, manufacturing, construction, autonomous operations and maintenance, power and heating/cooling, stable precision structures, optics, parabolic antennas, and communications/control. LOUISA needs to be engineered to operate for long periods with minimal intervention by humans or robots. What is essential for LOUISA operation is enforcement of a systems engineering approach that makes compatible all lunar operations associated with habitation, resource development, and science.

Synthesis of Feedback Controller for Chaotic Systems by Means of Evolutionary Techniques

NASA Astrophysics Data System (ADS)

Senkerik, Roman; Oplatkova, Zuzana; Zelinka, Ivan; Davendra, Donald; Jasek, Roman

2011-06-01

This research deals with a synthesis of control law for three selected discrete chaotic systems by means of analytic programming. The novality of the approach is that a tool for symbolic regression—analytic programming—is used for such kind of difficult problem. The paper consists of the descriptions of analytic programming as well as chaotic systems and used cost function. For experimentation, Self-Organizing Migrating Algorithm (SOMA) with analytic programming was used.

Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water.

PubMed

Poma, Alessandro; Guerreiro, Antonio; Caygill, Sarah; Moczko, Ewa; Piletsky, Sergey

We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, "ready for use" MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and α-amylase in only 4 hours.

Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water

PubMed Central

Poma, Alessandro; Guerreiro, Antonio; Caygill, Sarah; Moczko, Ewa; Piletsky, Sergey

2015-01-01

We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, “ready for use” MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and α-amylase in only 4 hours. PMID:26722622

Interfacing theories of program with theories of evaluation for advancing evaluation practice: Reductionism, systems thinking, and pragmatic synthesis.

PubMed

Chen, Huey T

2016-12-01

Theories of program and theories of evaluation form the foundation of program evaluation theories. Theories of program reflect assumptions on how to conceptualize an intervention program for evaluation purposes, while theories of evaluation reflect assumptions on how to design useful evaluation. These two types of theories are related, but often discussed separately. This paper attempts to use three theoretical perspectives (reductionism, systems thinking, and pragmatic synthesis) to interface them and discuss the implications for evaluation practice. Reductionism proposes that an intervention program can be broken into crucial components for rigorous analyses; systems thinking view an intervention program as dynamic and complex, requiring a holistic examination. In spite of their contributions, reductionism and systems thinking represent the extreme ends of a theoretical spectrum; many real-world programs, however, may fall in the middle. Pragmatic synthesis is being developed to serve these moderate- complexity programs. These three theoretical perspectives have their own strengths and challenges. Knowledge on these three perspectives and their evaluation implications can provide a better guide for designing fruitful evaluations, improving the quality of evaluation practice, informing potential areas for developing cutting-edge evaluation approaches, and contributing to advancing program evaluation toward a mature applied science. Copyright © 2016 Elsevier Ltd. All rights reserved.

2003 NASA Faculty Fellowship Program at Glenn Research Center

NASA Technical Reports Server (NTRS)

Prahl, Joseph M.; Heyward, An O.; Kankam, Mark D.

2003-01-01

The Office of Education at NASA Headquarters provides overall policy and direction for the NASA Faculty Fellowship Program (NFFP). The American Society for Engineering Education (ASEE) and the Universities Space Research Association (USRA) have joined in partnership to recruit participants, accept applications from a broad range of participants, and provide overall evaluation of the NFFP. The NASA Centers, through their University Affairs Officers, develop and operate the experiential part of the program. In concert with co-directing universities and the Centers, Fellows are selected and provided the actual research experiences. This report summarizes the 2003 session conducted at the Glenn Research Center (GRC).Research topics covered a variety of areas including, but not limited to, biological sensors, modeling of biological fluid systems, electronic circuits, ceramics and coatings, unsteady probablistic analysis and aerodynamics, gas turbines, environmental monitoring systems for water quality, air quality, gaseous and particulate emissions, bearings for flywheel energy storage, shape memory alloys,photonic interrogation and nanoprocesses,carbon nanotubes, polymer synthesis for fuel cells, aviation communications, algorithm development and RESPlan Database.

FWP executive summaries, Basic Energy Sciences Materials Sciences Programs (SNL/NM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Samara, G.A.

1997-05-01

The BES Materials Sciences Program has the central theme of Scientifically Tailored Materials. The major objective of this program is to combine Sandia`s expertise and capabilities in the areas of solid state sciences, advanced atomic-level diagnostics and materials synthesis and processing science to produce new classes of tailored materials as well as to enhance the properties of existing materials for US energy applications and for critical defense needs. Current core research in this program includes the physics and chemistry of ceramics synthesis and processing, the use of energetic particles for the synthesis and study of materials, tailored surfaces and interfacesmore » for materials applications, chemical vapor deposition sciences, artificially-structured semiconductor materials science, advanced growth techniques for improved semiconductor structures, transport in unconventional solids, atomic-level science of interfacial adhesion, high-temperature superconductors, and the synthesis and processing of nano-size clusters for energy applications. In addition, the program includes the following three smaller efforts initiated in the past two years: (1) Wetting and Flow of Liquid Metals and Amorphous Ceramics at Solid Interfaces, (2) Field-Structured Anisotropic Composites, and (3) Composition-Modulated Semiconductor Structures for Photovoltaic and Optical Technologies. The latter is a joint effort with the National Renewable Energy Laboratory. Separate summaries are given of individual research areas.« less

Synthesis: Intertwining product and process

NASA Technical Reports Server (NTRS)

Weiss, David M.

1990-01-01

Synthesis is a proposed systematic process for rapidly creating different members of a program family. Family members are described by variations in their requirements. Requirements variations are mapped to variations on a standard design to generate production quality code and documentation. The approach is made feasible by using principles underlying design for change. Synthesis incorporates ideas from rapid prototyping, application generators, and domain analysis. The goals of Synthesis and the Synthesis process are discussed. The technology needed and the feasibility of the approach are also briefly discussed. The status of current efforts to implement Synthesis methodologies is presented.

Development of a weight/sizing design synthesis computer program. Volume 1: Program formulation

NASA Technical Reports Server (NTRS)

Garrison, J. M.

1973-01-01

The development of a weight/sizing design synthesis methodology for use in support of the main line space shuttle program is discussed. The methodology has a minimum number of data inputs and quick turn around capabilities. The methodology makes it possible to: (1) make weight comparisons between current shuttle configurations and proposed changes, (2) determine the effects of various subsystems trades on total systems weight, and (3) determine the effects of weight on performance and performance on weight.

A synthesis of evaluation monitoring projects by the forest health monitoring program (1998-2007)

Treesearch

William A. Bechtold; Michael J. Bohne; Barbara L. Conkling; Dana L. Friedman

2012-01-01

The national Forest Health Monitoring Program of the Forest Service, U.S. Department of Agriculture, has funded over 200 Evaluation Monitoring projects. Evaluation Monitoring is designed to verify and define the extent of deterioration in forest ecosystems where potential problems have been identified. This report is a synthesis of results from over 150 Evaluation...

Expert System for Automated Design Synthesis

NASA Technical Reports Server (NTRS)

Rogers, James L., Jr.; Barthelemy, Jean-Francois M.

1987-01-01

Expert-system computer program EXADS developed to aid users of Automated Design Synthesis (ADS) general-purpose optimization program. EXADS aids engineer in determining best combination based on knowledge of specific problem and expert knowledge stored in knowledge base. Available in two interactive machine versions. IBM PC version (LAR-13687) written in IQ-LISP. DEC VAX version (LAR-13688) written in Franz-LISP.

Interactive program for analysis and design problems in advanced composites technology

NASA Technical Reports Server (NTRS)

Cruse, T. A.; Swedlow, J. L.

1971-01-01

During the past year an experimental program in the fracture of advanced fiber composites has been completed. The experimental program has given direction to additional experimental and theoretical work. A synthesis program for designing low weight multifastener joints in composites is proposed, based on extensive analytical background. A number of failed joints have been thoroughly analyzed to evaluate the failure hypothesis used in the synthesis procedure. Finally, a new solution is reported for isotropic and anisotropic laminates using the boundary-integral method. The solution method offers significant savings of computer core and time for important problems.

General aviation design synthesis utilizing interactive computer graphics

NASA Technical Reports Server (NTRS)

Galloway, T. L.; Smith, M. R.

1976-01-01

Interactive computer graphics is a fast growing area of computer application, due to such factors as substantial cost reductions in hardware, general availability of software, and expanded data communication networks. In addition to allowing faster and more meaningful input/output, computer graphics permits the use of data in graphic form to carry out parametric studies for configuration selection and for assessing the impact of advanced technologies on general aviation designs. The incorporation of interactive computer graphics into a NASA developed general aviation synthesis program is described, and the potential uses of the synthesis program in preliminary design are demonstrated.

Hanford Laboratories Operation monthly activities report, August 1959

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1959-09-15

This is the monthly report for the Hanford Laboratories Operation, August, 1959. Reactor fuels, chemistry, dosimetry, separation processes, reactor technology financial activities, visits, biology operation, physics and instrumentation research, employee relations, and operations research and synthesis operation are discussed.

Preliminary performance estimates of a highly maneuverable remotely piloted vehicle. [computerized synthesis program to assess effects of vehicle and mission parameters

NASA Technical Reports Server (NTRS)

Nelms, W. P., Jr.; Axelson, J. A.

1974-01-01

A computerized synthesis program has been used to assess the effects of various vehicle and mission parameters on the performance of a highly maneuverable remotely piloted vehicle (RPV) for the air-to-air combat role. The configuration used in the study is a trapezoidal-wing and body concept, with forward-mounted stabilizing and control surfaces. The study mission consists of an outbound cruise, an acceleration phase, a series of subsonic and supersonic turns, and a return cruise. Performance is evaluated in terms of both the required vehicle weight to accomplish this mission and combat effectiveness as measured by turning and acceleration capability. The report describes the synthesis program, the mission, the vehicle, and the results of sensitivity and trade studies.

Berkeley Lab - Materials Sciences Division

Science.gov Websites

Synthesis Condensed Matter and Materials Physics Scattering and Instrumentation Science Centers Center for ; Finance Templates Travel One-Stop Core Programs Materials Discovery, Design and Synthesis Condensed Matter

Tactical Synthesis Of Efficient Global Search Algorithms

NASA Technical Reports Server (NTRS)

Nedunuri, Srinivas; Smith, Douglas R.; Cook, William R.

2009-01-01

Algorithm synthesis transforms a formal specification into an efficient algorithm to solve a problem. Algorithm synthesis in Specware combines the formal specification of a problem with a high-level algorithm strategy. To derive an efficient algorithm, a developer must define operators that refine the algorithm by combining the generic operators in the algorithm with the details of the problem specification. This derivation requires skill and a deep understanding of the problem and the algorithmic strategy. In this paper we introduce two tactics to ease this process. The tactics serve a similar purpose to tactics used for determining indefinite integrals in calculus, that is suggesting possible ways to attack the problem.

GASP- GENERAL AVIATION SYNTHESIS PROGRAM

NASA Technical Reports Server (NTRS)

Galloway, T. L.

1994-01-01

The General Aviation Synthesis Program, GASP, was developed to perform tasks generally associated with the preliminary phase of aircraft design. GASP gives the analyst the capability of performing parametric studies in a rapid manner during preliminary design efforts. During the development of GASP, emphasis was placed on small fixed-wing aircraft employing propulsion systems varying from a single piston engine with a fixed pitch propeller through twin turboprop/turbofan systems as employed in business or transport type aircraft. The program is comprised of modules representing the various technical disciplines of design, integrated into a computational flow which ensures that the interacting effects of design variables are continuously accounted for in the aircraft sizing procedures. GASP provides a useful tool for comparing configurations, assessing aircraft performance and economics, and performing tradeoff and sensitivity studies. By utilizing GASP, the impact of various aircraft requirements and design factors may be studied in a systematic manner, with benefits being measured in terms of overall aircraft performance and economics. The GASP program consists of a control module and six "technology" submodules which perform the various independent studies required in the design of general aviation or small transport type aircraft. The six technology modules include geometry, aerodynamics, propulsion, weight and balance, mission analysis, and economics. The geometry module calculates the dimensions of the synthesized aircraft components based on such input parameters as number of passengers, aspect ratio, taper ratio, sweep angles, and thickness of wing and tail surfaces. The aerodynamics module calculates the various lift and drag coefficients of the synthesized aircraft based on inputs concerning configuration geometry, flight conditions, and type of high lift device. The propulsion module determines the engine size and performance for the synthesized aircraft. Both cruise and take-off requirements for the aircraft may be specified. This module can currently simulate turbojet, turbofan, turboprop, and reciprocating or rotating combustion engines. The weight and balance module accepts as input gross weight, payload, aircraft geometry, and weight trend coefficients for use in calculating the size of tip tanks and wing location required such that the synthesized aircraft is in balance for center of gravity travel. In the mission analysis module, the taxi, take-off, climb, cruise, and landing segments of a specified mission are analyzed to compute the total range, and the aircraft size required to provide this range is determined. In the economic module both the flyaway and operating costs are determined from estimated resources and services cost. The six technology modules are integrated into a single synthesis system by the control module. This integrated approach ensures that the results from each module contain the effect of design interactions among all the modules. Starting from a set of simple input quantities concerning aircraft type, size, and performance, the synthesis is extended to the point where all of the important aircraft characteristics have been analyzed quantitatively. Together, the synthesis model and procedure develops aircraft configurations in a manner useful in parametric analysis and provides a useful step toward more detailed analytical and experimental studies. The GASP program is written in FORTRAN IV for batch execution and has been implemented on a CDC CYBER 170 series computer with a central memory requirement of approximately 200K(octal) of 60 bit words. The GASP program was developed in 1978.

Applying Aspect-Oriented Programming to Intelligent Synthesis

NASA Technical Reports Server (NTRS)

Filman, Robert E.; Norvig, Peter (Technical Monitor)

2000-01-01

I discuss a component-centered, aspect-oriented system, the Object Infrastructure Framework (OIF), NASA's initiative on Intelligent Synthesis Environments (ISE), and the application of OIF to the architecture of ISE.

A Research Synthesis of the Evaluation Capacity Building Literature

ERIC Educational Resources Information Center

Labin, Susan N.; Duffy, Jennifer L.; Meyers, Duncan C.; Wandersman, Abraham; Lesesne, Catherine A.

2012-01-01

The continuously growing demand for program results has produced an increased need for evaluation capacity building (ECB). The "Integrative ECB Model" was developed to integrate concepts from existing ECB theory literature and to structure a synthesis of the empirical ECB literature. The study used a broad-based research synthesis method with…

Alabama NASA EPSCoR Preparation Grant Program: Grant No. NCC5-391

NASA Technical Reports Server (NTRS)

Gregory, John C.

2003-01-01

The funded research projects under the Experimental Program to Stimulate Cooperative Research (EPSCoR) grant program and the student fellowship awards are summarized in this report. The projects include: 1) Crystallization of Dehydratase/DcoH: A Target in Lung Disease; 2) Measuring Velocity Profiles in Liquid Metals using an Ultrasonic Doppler Velocimeter; 3) Synthesis, Structure, and Properties of New Thermoelectric Materials; 4) Computational Determination of Structures and Reactivity of Phenol-Formaldehyde Resins; 5) Synthesis of Microbial Polyesters in the NASA Bioreactor; 6) Visualization of Flow-Fields in Magnetocombustion; 7) Synthesis of Fluorescent Saccharide Derivatives. The student fellowship awards include: 1) Distributed Fusion of Satellite Images; 2) Study of the Relationship between Urban Development, Local Climate, and Water Quality for the Atlanta, Georgia Metrop; 3) Computer Simulation of the Effectiveness of a Spring-Loaded Exercise Device.

34 CFR 668.10 - Direct assessment programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... such as creativity, analysis or synthesis associated with the subject matter of the program. Examples... measurement apply to direct assessment programs. Because a direct assessment program does not utilize credit... program includes regularly scheduled learning sessions, faculty-guided independent study, consultations...

Impact of Garden-Based Learning on Academic Outcomes in Schools: Synthesis of Research between 1990 and 2010

ERIC Educational Resources Information Center

Williams, Dilafruz R.; Dixon, P. Scott

2013-01-01

What is the impact of garden-based learning on academic outcomes in schools? To address this question, findings across 152 articles (1990-2010) were analyzed resulting in 48 studies that met the inclusion criteria for this synthesis. A review template with operational coding framework was developed. The synthesis results showed a preponderance of…

Computer program to assess impact of fatigue and fracture criteria on weight and cost of transport aircraft

NASA Technical Reports Server (NTRS)

Tanner, C. J.; Kruse, G. S.; Oman, B. H.

1975-01-01

A preliminary design analysis tool for rapidly performing trade-off studies involving fatigue, fracture, static strength, weight, and cost is presented. Analysis subprograms were developed for fatigue life, crack growth life, and residual strength; and linked to a structural synthesis module which in turn was integrated into a computer program. The part definition module of a cost and weight analysis program was expanded to be compatible with the upgraded structural synthesis capability. The resultant vehicle design and evaluation program is named VDEP-2. It is an accurate and useful tool for estimating purposes at the preliminary design stage of airframe development. A sample case along with an explanation of program applications and input preparation is presented.

Robust Temperature Control of a Thermoelectric Cooler via μ -Synthesis

NASA Astrophysics Data System (ADS)

Kürkçü, Burak; Kasnakoğlu, Coşku

2018-02-01

In this work robust temperature control of a thermoelectric cooler (TEC) via μ -synthesis is studied. An uncertain dynamical model for the TEC that is suitable for robust control methods is derived. The model captures variations in operating point due to current, load and temperature changes. A temperature controller is designed utilizing μ -synthesis, a powerful method guaranteeing robust stability and performance. For comparison two well-known control methods, namely proportional-integral-derivative (PID) and internal model control (IMC), are also realized to benchmark the proposed approach. It is observed that the stability and performance on the nominal model are satisfactory for all cases. On the other hand, under perturbations the responses of PID and IMC deteriorate and even become unstable. In contrast, the μ -synthesis controller succeeds in keeping system stability and achieving good performance under all perturbations within the operating range, while at the same time providing good disturbance rejection.

Maximization of fructose esters synthesis by response surface methodology.

PubMed

Neta, Nair Sampaio; Peres, António M; Teixeira, José A; Rodrigues, Ligia R

2011-07-01

Enzymatic synthesis of fructose fatty acid ester was performed in organic solvent media, using a purified lipase from Candida antartica B immobilized in acrylic resin. Response surface methodology with a central composite rotatable design based on five levels was implemented to optimize three experimental operating conditions (temperature, agitation and reaction time). A statistical significant cubic model was established. Temperature and reaction time were found to be the most significant parameters. The optimum operational conditions for maximizing the synthesis of fructose esters were 57.1°C, 100 rpm and 37.8 h. The model was validated in the identified optimal conditions to check its adequacy and accuracy, and an experimental esterification percentage of 88.4% (±0.3%) was obtained. These results showed that an improvement of the enzymatic synthesis of fructose esters was obtained under the optimized conditions. Copyright © 2011 Elsevier B.V. All rights reserved.

Profiles of the biosynthesis and metabolism of pyridine nucleotides in potatoes (Solanum tuberosum L.).

PubMed

Katahira, Riko; Ashihara, Hiroshi

2009-12-01

As part of a research program on nucleotide metabolism in potato tubers (Solanum tuberosum L.), profiles of pyridine (nicotinamide) metabolism were examined based on the in situ metabolic fate of radio-labelled precursors and the in vitro activities of enzymes. In potato tubers, [(3)H]quinolinic acid, which is an intermediate of de novo pyridine nucleotide synthesis, and [(14)C]nicotinamide, a catabolite of NAD, were utilised for pyridine nucleotide synthesis. The in situ tracer experiments and in vitro enzyme assays suggest the operation of multiple pyridine nucleotide cycles. In addition to the previously proposed cycle consisting of seven metabolites, we found a new cycle that includes newly discovered nicotinamide riboside deaminase which is also functional in potato tubers. This cycle bypasses nicotinamide and nicotinic acid; it is NAD --> nicotinamide mononucleotide --> nicotinamide riboside --> nicotinic acid riboside --> nicotinic acid mononucleotide --> nicotinic acid adenine dinucleotide --> NAD. Degradation of the pyridine ring was extremely low in potato tubers. Nicotinic acid glucoside is formed from nicotinic acid in potato tubers. Comparative studies of [carboxyl-(14)C]nicotinic acid metabolism indicate that nicotinic acid is converted to nicotinic acid glucoside in all organs of potato plants. Trigonelline synthesis from [carboxyl-(14)C]nicotinic acid was also found. Conversion was greater in green parts of plants, such as leaves and stem, than in underground parts of potato plants. Nicotinic acid utilised for the biosynthesis of these conjugates seems to be derived not only from the pyridine nucleotide cycle, but also from the de novo synthesis of nicotinic acid mononucleotide.

Cobalt–iron nano catalysts supported on TiO{sub 2}–SiO{sub 2}: Characterization and catalytic performance in Fischer–Tropsch synthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feyzi, Mostafa, E-mail: Dalahoo2011@yahoo.com; Yaghobi, Nakisa; Eslamimanesh, Vahid

2015-12-15

Graphical abstract: The Co–Fe/TiO{sub 2}–SiO{sub 2} catalysts were prepared. The prepared catalysts were tested for light olefins and C{sub 5}–C{sub 12} production. The best operational conditions are 250 °C, H{sub 2}/CO = 1/1 under 5 bar pressure. - Highlights: • The TiO{sub 2}–SiO{sub 2} supported cobalt–iron catalysts were prepared via sol–gel method. • The best operational conditions were 250 °C, GHSV = 2000 h{sup −1}, H{sub 2}/CO = 1/1 and 5 bar. • The (Co/Fe)/TiO{sub 2}–SiO{sub 2} is efficient catalyst for light olefins and C{sub 5}–C{sub 12} production. - Abstract: A series of Co–Fe catalysts supported on TiO{sub 2}–SiO{sub 2}more » were prepared by the sol–gel method. This research investigated the effects of (Co/Fe) wt.%, the solution pH, different Co/Fe molar ratio, calcination conditions and different promoters on the catalytic performance of cobalt–iron catalysts for the Fisher–Tropsch synthesis (FTS). It was found that the catalyst containing 35 wt.% (Co–Fe)/TiO{sub 2}–SiO{sub 2} (Co/Fe molar ratio is 80/20) promoted with 1.5 wt.% Cu and calcined in air atmosphere at 600 °C for 7 h with a heating rate of 3 °C min{sup −1} is an optimal nano catalyst for converting synthesis gas to light olefins and C{sub 5}–C{sub 12} hydrocarbons. The effects of operational conditions such as the H{sub 2}/CO ratio, gas hourly space velocity (GHSV), different reaction temperature, and reaction pressure were investigated. The results showed that the best operational conditions for optimal nano catalyst are 250 °C, GHSV = 2000 h{sup −1}, H{sub 2}/CO molar ratio 1/1 under 5 bar total pressure. Catalysts and precursors were characterized by, X-ray diffraction (XRD), scanning electron microcopy (SEM), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), temperature program reduction (TPR) and N{sub 2} adsorption–desorption measurements.« less

Linear systems analysis program, L224(QR). Volume 2: Supplemental system design and maintenance document

NASA Technical Reports Server (NTRS)

Heidergott, K. W.

1979-01-01

The computer program known as QR is described. Classical control systems analysis and synthesis (root locus, time response, and frequency response) can be performed using this program. Programming details of the QR program are presented.

Space shuttle/payload interface analysis. Volume 4: Business Risk and Value of Operations in Space (BRAVO). Part 3: Workbook

NASA Technical Reports Server (NTRS)

1974-01-01

A collection of blank worksheets for use on each BRAVO problem to be analyzed is supplied, for the purposes of recording the inputs for the BRAVO analysis, working out the definition of mission equipment, recording inputs to the satellite synthesis computer program, estimating satellite earth station costs, costing terrestrial systems, and cost effectiveness calculations. The group of analysts working BRAVO will normally use a set of worksheets on each problem, however, the workbook pages are of sufficiently good quality that the user can duplicate them, if more worksheet blanks are required than supplied. For Vol. 1, see N74-12493; for Vol. 2, see N74-14530.

Synthesis and analysis of precise spaceborne laser ranging systems, volume 1. [link analysis

NASA Technical Reports Server (NTRS)

Paddon, E. A.

1977-01-01

Measurement accuracy goals of 2 cm rms range estimation error and 0.003 cm/sec rms range rate estimation error, with no more than 1 cm (range) static bias error are requirements for laser measurement systems to be used in planned space-based earth physics investigations. Constraints and parameters were defined for links between a high altitude, transmit/receive satellite (HATRS), and one of three targets: a low altitude target satellite, passive (LATS), and active low altitude target, and a ground-based target, as well as with operations with a primary transmit/receive terminal intended to be carried as a shuttle payload, in conjunction with the Spacelab program.

Adsorptive removal of catalyst poisons from coal gas for methanol synthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhatt, B.L.; Golden, T.C.; Hsiung, T.H.

1991-12-01

As an integral part of the liquid-phase methanol (LPMEOH) process development program, the present study evaluated adsorptive schemes to remove traces of catalyst poisons such as iron carbonyl, carbonyl sulfide, and hydrogen sulfide from coal gas on a pilot scale. Tests were conducted with coal gas from the Cool Water gasification plant at Daggett, California. Iron carbonyl, carbonyl sulfide, and hydrogen sulfide were effectively removed from the coal gas. The adsorption capacities of Linde H-Y zeolite and Calgon BPL carbon for Fe(CO){sub 5} compared well with previous bench-scale results at similar CO{sub 2} partial pressure. Adsorption of COS by Calgonmore » FCA carbon appeared to be chemical and nonregenerable by thermal treatment in nitrogen. A Cu/Zn catalyst removed H{sub 2}S very effectively. With the adsorption system on-line, a methanol catalyst showed stable activity during 120 h operation, demonstrating the feasibility of adsorptive removal of trace catalyst poisons from the synthesis gas. Mass transfer coefficients were estimated for Fe(CO){sub 5} and COS removal which can be directly used for design and scale up.« less

Effects of cycloheximide on extinction in an appetitively motivated operant conditioning task depend on re-exposure duration.

PubMed

Mierzejewski, Pawel; Olczak, Mieszko; Rogowski, Artur; Kostowski, Wojciech; Samochowiec, Jerzy; Filip, Malgorzata; Przegalinski, Edmund; Bienkowski, Przemyslaw

2008-08-29

Little is known about the role of new protein synthesis in extinction of operant responding for natural and chemical reinforcers. In the present study, the authors investigated whether the effects of a protein synthesis inhibitor, cycloheximide (CHX) on extinction of operant responding for sweet reward depended on the duration of re-exposure sessions. In addition, the authors investigated whether the effects of CHX on extinction could generalize to relapse of saccharin seeking induced by discrete cues. CHX injected after short re-exposure sessions (5min) accelerated extinction of non-reinforced responding. In contrast, the drug injected after long re-exposure sessions (30min) partially inhibited extinction. Reinstatement of saccharin seeking induced by the saccharin-paired discrete cues was not altered by the previous treatment with CHX. Concluding, the results of the present study indicate that: (i) the protein synthesis inhibitor, CHX can alter extinction of operant responding for sweet reward in rats; (ii) the effects of CHX on extinction critically depend on the duration of re-exposure/extinction sessions and do not generalize to relapse of saccharin seeking induced by discrete cues.

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

PubMed

Wyatt, Emma E; Galloway, Warren R J D; Thomas, Gemma L; Welch, Martin; Loiseleur, Olivier; Plowright, Alleyn T; Spring, David R

2008-10-28

The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of Staphylococcus aureus dihydrofolate reductase.

The extended evolutionary synthesis: its structure, assumptions and predictions

PubMed Central

Laland, Kevin N.; Uller, Tobias; Feldman, Marcus W.; Sterelny, Kim; Müller, Gerd B.; Moczek, Armin; Jablonka, Eva; Odling-Smee, John

2015-01-01

Scientific activities take place within the structured sets of ideas and assumptions that define a field and its practices. The conceptual framework of evolutionary biology emerged with the Modern Synthesis in the early twentieth century and has since expanded into a highly successful research program to explore the processes of diversification and adaptation. Nonetheless, the ability of that framework satisfactorily to accommodate the rapid advances in developmental biology, genomics and ecology has been questioned. We review some of these arguments, focusing on literatures (evo-devo, developmental plasticity, inclusive inheritance and niche construction) whose implications for evolution can be interpreted in two ways—one that preserves the internal structure of contemporary evolutionary theory and one that points towards an alternative conceptual framework. The latter, which we label the ‘extended evolutionary synthesis' (EES), retains the fundaments of evolutionary theory, but differs in its emphasis on the role of constructive processes in development and evolution, and reciprocal portrayals of causation. In the EES, developmental processes, operating through developmental bias, inclusive inheritance and niche construction, share responsibility for the direction and rate of evolution, the origin of character variation and organism–environment complementarity. We spell out the structure, core assumptions and novel predictions of the EES, and show how it can be deployed to stimulate and advance research in those fields that study or use evolutionary biology. PMID:26246559

Users manual for the Variable dimension Automatic Synthesis Program (VASP)

NASA Technical Reports Server (NTRS)

White, J. S.; Lee, H. Q.

1971-01-01

A dictionary and some problems for the Variable Automatic Synthesis Program VASP are submitted. The dictionary contains a description of each subroutine and instructions on its use. The example problems give the user a better perspective on the use of VASP for solving problems in modern control theory. These example problems include dynamic response, optimal control gain, solution of the sampled data matrix Ricatti equation, matrix decomposition, and pseudo inverse of a matrix. Listings of all subroutines are also included. The VASP program has been adapted to run in the conversational mode on the Ames 360/67 computer.

Modeling and Synthesis Support for the North American Carbon Program

NASA Astrophysics Data System (ADS)

Baskaran, L.; Cook, R. B.; Thornton, P. E.; Post, W. M.; Wilson, B. E.; Dadi, U.

2007-12-01

The Modeling and Synthesis Thematic Data Center (MAST-DC) supports the North American Carbon Program by providing data products and data management services needed for modeling and synthesis activities. The overall objective of MAST-DC is to provide advanced data management support to NACP investigators doing modeling and synthesis, thereby freeing those investigators from having to perform data management functions. MAST-DC has compiled a number of data products for North America, including sub-pixel land-water content, daily meteorological data, and soil, land cover, and elevation data. In addition, we have developed an internet-based WebGIS system that enables users to browse, query, display, subset, and download spatial data using a standard web browser. For the mid-continent intensive, MAST-DC is working with a group of data assimilation modelers to generate a consistent set of meteorological data to drive bottom-up models.

ADS: A FORTRAN program for automated design synthesis: Version 1.10

NASA Technical Reports Server (NTRS)

Vanderplaats, G. N.

1985-01-01

A new general-purpose optimization program for engineering design is described. ADS (Automated Design Synthesis - Version 1.10) is a FORTRAN program for solution of nonlinear constrained optimization problems. The program is segmented into three levels: strategy, optimizer, and one-dimensional search. At each level, several options are available so that a total of over 100 possible combinations can be created. Examples of available strategies are sequential unconstrained minimization, the Augmented Lagrange Multiplier method, and Sequential Linear Programming. Available optimizers include variable metric methods and the Method of Feasible Directions as examples, and one-dimensional search options include polynomial interpolation and the Golden Section method as examples. Emphasis is placed on ease of use of the program. All information is transferred via a single parameter list. Default values are provided for all internal program parameters such as convergence criteria, and the user is given a simple means to over-ride these, if desired.

Task planning and control synthesis for robotic manipulation in space applications

NASA Technical Reports Server (NTRS)

Sanderson, A. C.; Peshkin, M. A.; Homem-De-mello, L. S.

1987-01-01

Space-based robotic systems for diagnosis, repair and assembly of systems will require new techniques of planning and manipulation to accomplish these complex tasks. Results of work in assembly task representation, discrete task planning, and control synthesis which provide a design environment for flexible assembly systems in manufacturing applications, and which extend to planning of manipulatiuon operations in unstructured environments are summarized. Assembly planning is carried out using the AND/OR graph representation which encompasses all possible partial orders of operations and may be used to plan assembly sequences. Discrete task planning uses the configuration map which facilitates search over a space of discrete operations parameters in sequential operations in order to achieve required goals in the space of bounded configuration sets.

Development and Validation of a Primary Care-Based Family Health History and Decision Support Program (MeTree)

PubMed Central

Orlando, Lori A.; Buchanan, Adam H.; Hahn, Susan E.; Christianson, Carol A.; Powell, Karen P.; Skinner, Celette Sugg; Chesnut, Blair; Blach, Colette; Due, Barbara; Ginsburg, Geoffrey S.; Henrich, Vincent C.

2016-01-01

INTRODUCTION Family health history is a strong predictor of disease risk. To reduce the morbidity and mortality of many chronic diseases, risk-stratified evidence-based guidelines strongly encourage the collection and synthesis of family health history to guide selection of primary prevention strategies. However, the collection and synthesis of such information is not well integrated into clinical practice. To address barriers to collection and use of family health histories, the Genomedical Connection developed and validated MeTree, a Web-based, patient-facing family health history collection and clinical decision support tool. MeTree is designed for integration into primary care practices as part of the genomic medicine model for primary care. METHODS We describe the guiding principles, operational characteristics, algorithm development, and coding used to develop MeTree. Validation was performed through stakeholder cognitive interviewing, a genetic counseling pilot program, and clinical practice pilot programs in 2 community-based primary care clinics. RESULTS Stakeholder feedback resulted in changes to MeTree’s interface and changes to the phrasing of clinical decision support documents. The pilot studies resulted in the identification and correction of coding errors and the reformatting of clinical decision support documents. MeTree’s strengths in comparison with other tools are its seamless integration into clinical practice and its provision of action-oriented recommendations guided by providers’ needs. LIMITATIONS The tool was validated in a small cohort. CONCLUSION MeTree can be integrated into primary care practices to help providers collect and synthesize family health history information from patients with the goal of improving adherence to risk-stratified evidence-based guidelines. PMID:24044145

Defense Small Business Innovation Research Program (SBIR). Volume 3. Air Force Abstracts of Phase 1 Awards 1987.

DTIC Science & Technology

1988-04-01

RESISTANCE, AS WELL AS GUIDELINES FROM APPROPRIATE AEROSPACE SPECIFICATIONS; MATERIALS WILL INCLUDE ALUMINUM AND TITANIUM ALLOYS, PLUS A FEW STEELS...VAPOR SYNTHESIS OF NIOBIUM ALUMINIDES TOPIC# 105 OFFICE: AFWAL/ML DIRECT SYNTHESIS OF NbA1 ALLOY FOILS BY CHEMICAL VAPOR DEPOSITION ONTO INERT SUBSTRATES...GROWT OF GAMMA PRIME NICKEL ALUMINIDE (Ni3AI) %% TOPICt 104 OFFICE: AFWAL/ML . SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM - PHASE 1 PAGE 555

Cops, cameras, and enclosures : a synthesis of the effectiveness of methods to provide enhanced security for bus operators

DOT National Transportation Integrated Search

2001-05-31

The safety of operators and passengers is a primary concern of transit systems and has become an increasingly important issue to transit bus operators themselves. Many transit agencies have experienced incidents of assaults against their bus operator...

Synthesis of multiple shaped beam antenna patterns

NASA Technical Reports Server (NTRS)

Stutzman, W. L.; Coffey, E. L.

1973-01-01

Results are presented of research into the problem of finding an excitation of a given antenna such that the desired radiation pattern is approximated to within acceptable limits. This is to be done in such a fashion that boundary conditions involving hardware limitations may be inserted into the problem. The intended application is synthesis of multiple shaped beam antennas. Since this is perhaps the most difficult synthesis problem an antenna engineer is likely to encounter, the approach taken was to include as a by-product capability for synthesizing simpler patterns. The synthesis technique has been almost totally computerized. The class of antennas which may be synthesized with the computer program are those which may be represented as planar (continuous or discrete) current distributions. The technique is not limited in this sense and could indeed by extended to include, for example, the synthesis of conformal arrays or current distributions on the surface of reflectors. The antenna types which the program is set up to synthesize are: line source, rectangular aperture, circular aperture, linear array, rectangular array, and arbitrary planar array.

Ion transport membrane reactor systems and methods for producing synthesis gas

DOEpatents

Repasky, John Michael

2015-05-12

Embodiments of the present invention provide cost-effective systems and methods for producing a synthesis gas product using a steam reformer system and an ion transport membrane (ITM) reactor having multiple stages, without requiring inter-stage reactant injections. Embodiments of the present invention also provide techniques for compensating for membrane performance degradation and other changes in system operating conditions that negatively affect synthesis gas production.

An Experiment in Linguistic Synthesis with a Fuzzy Logic Controller

ERIC Educational Resources Information Center

Mamdani, E. H.; Assilian, S.

1975-01-01

This paper describes an experiment on the "linguistic" synthesis of a controller for a model industrial plant (a steam engine). Fuzzy logic is used to convert heuristic control rules stated by a human operator into an automatic control strategy. (Author)

Theoretical Studies of Microstrip Antennas : Volume II, Analysis and Synthesis of Multi-Frequency Elements

DOT National Transportation Integrated Search

1979-09-01

Volume II of Theoretical Studies of Microstrip Antennas deals with the analysis and synthesis of several types of novel multi-resonant elements with emphasis on dual-frequency operation of rectangular microstrip patch antennas with or without externa...

Optimization of Synthesis Conditions of Carbon Nanotubes via Ultrasonic-Assisted Floating Catalyst Deposition Using Response Surface Methodology

PubMed Central

Mohammadian, Narges; Ghoreishi, Seyyed M.; Hafeziyeh, Samira; Saeidi, Samrand; Dionysiou, Dionysios D.

2018-01-01

The growing use of carbon nanotubes (CNTs) in a plethora of applications has provided to us a motivation to investigate CNT synthesis by new methods. In this study, ultrasonic-assisted chemical vapor deposition (CVD) method was employed to synthesize CNTs. The difficulty of controlling the size of clusters and achieving uniform distribution—the major problem in previous methods—was solved by using ultrasonic bath and dissolving ferrocene in xylene outside the reactor. The operating conditions were optimized using a rotatable central composite design (CCD), which helped optimize the operating conditions of the method. Response surface methodology (RSM) was used to analyze these experiments. Using statistical software was very effective, considering that it decreased the number of experiments needed to achieve the optimum conditions. Synthesis of CNTs was studied as a function of three independent parameters viz. hydrogen flow rate (120–280 cm3/min), catalyst concentration (2–6 wt %), and synthesis temperature (800–1200 °C). Optimum conditions for the synthesis of CNTs were found to be 3.78 wt %, 184 cm3/min, and 976 °C for catalyst concentration, hydrogen flow rate, and synthesis temperature, respectively. Under these conditions, Raman spectrum indicates high values of (IG/ID), which means high-quality CNTs. PMID:29747451

Intelligent microchip networks: an agent-on-chip synthesis framework for the design of smart and robust sensor networks

NASA Astrophysics Data System (ADS)

Bosse, Stefan

2013-05-01

Sensorial materials consisting of high-density, miniaturized, and embedded sensor networks require new robust and reliable data processing and communication approaches. Structural health monitoring is one major field of application for sensorial materials. Each sensor node provides some kind of sensor, electronics, data processing, and communication with a strong focus on microchip-level implementation to meet the goals of miniaturization and low-power energy environments, a prerequisite for autonomous behaviour and operation. Reliability requires robustness of the entire system in the presence of node, link, data processing, and communication failures. Interaction between nodes is required to manage and distribute information. One common interaction model is the mobile agent. An agent approach provides stronger autonomy than a traditional object or remote-procedure-call based approach. Agents can decide for themselves, which actions are performed, and they are capable of flexible behaviour, reacting on the environment and other agents, providing some degree of robustness. Traditionally multi-agent systems are abstract programming models which are implemented in software and executed on program controlled computer architectures. This approach does not well scale to micro-chip level and requires full equipped computers and communication structures, and the hardware architecture does not consider and reflect the requirements for agent processing and interaction. We propose and demonstrate a novel design paradigm for reliable distributed data processing systems and a synthesis methodology and framework for multi-agent systems implementable entirely on microchip-level with resource and power constrained digital logic supporting Agent-On-Chip architectures (AoC). The agent behaviour and mobility is fully integrated on the micro-chip using pipelined communicating processes implemented with finite-state machines and register-transfer logic. The agent behaviour, interaction (communication), and mobility features are modelled and specified on a machine-independent abstract programming level using a state-based agent behaviour language (APL). With this APL a high-level agent compiler is able to synthesize a hardware model (RTL, VHDL), a software model (C, ML), or a simulation model (XML) suitable to simulate a multi-agent system using the SeSAm simulator framework. Agent communication is provided by a simple tuple-space database implemented on node level providing fault tolerant access of global data. A novel synthesis development kit (SynDK) based on a graph-structured database approach is introduced to support the rapid development of compilers and synthesis tools, used for example for the design and implementation of the APL compiler.

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

PubMed Central

Shukla, Chinmay A

2017-01-01

The implementation of automation in the multistep flow synthesis is essential for transforming laboratory-scale chemistry into a reliable industrial process. In this review, we briefly introduce the role of automation based on its application in synthesis viz. auto sampling and inline monitoring, optimization and process control. Subsequently, we have critically reviewed a few multistep flow synthesis and suggested a possible control strategy to be implemented so that it helps to reliably transfer the laboratory-scale synthesis strategy to a pilot scale at its optimum conditions. Due to the vast literature in multistep synthesis, we have classified the literature and have identified the case studies based on few criteria viz. type of reaction, heating methods, processes involving in-line separation units, telescopic synthesis, processes involving in-line quenching and process with the smallest time scale of operation. This classification will cover the broader range in the multistep synthesis literature. PMID:28684977

Synthesis of the project leadership staffing needs for successful development of alternative delivery programs.

DOT National Transportation Integrated Search

2017-08-01

This research provides a synthesis of practices in organizational structuring and professional staffing of the innovative delivery units in several state DOTs across the nation that are actively utilizing alternative project delivery. Several major c...

Correlation between Fischer-Tropsch catalytic activity and composition of catalysts

PubMed Central

2011-01-01

This paper presents the synthesis and characterization of monometallic and bimetallic cobalt and iron nanoparticles supported on alumina. The catalysts were prepared by a wet impregnation method. Samples were characterized using temperature-programmed reduction (TPR), temperature-programmed oxidation (TPO), CO-chemisorption, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM-EDX) and N2-adsorption analysis. Fischer-Tropsch synthesis (FTS) was carried out in a fixed-bed microreactor at 543 K and 1 atm, with H2/CO = 2 v/v and space velocity, SV = 12L/g.h. The physicochemical properties and the FTS activity of the bimetallic catalysts were analyzed and compared with those of monometallic cobalt and iron catalysts at similar operating conditions. H2-TPR analysis of cobalt catalyst indicated three temperature regions at 506°C (low), 650°C (medium) and 731°C (high). The incorporation of iron up to 30% into cobalt catalysts increased the reduction, CO chemisorption and number of cobalt active sites of the catalyst while an opposite trend was observed for the iron-riched bimetallic catalysts. The CO conversion was 6.3% and 4.6%, over the monometallic cobalt and iron catalysts, respectively. Bimetallic catalysts enhanced the CO conversion. Amongst the catalysts studied, bimetallic catalyst with the composition of 70Co30Fe showed the highest CO conversion (8.1%) while exhibiting the same product selectivity as that of monometallic Co catalyst. Monometallic iron catalyst showed the lowest selectivity for C5+ hydrocarbons (1.6%). PMID:22047220

“Synthesis-on” and “synthesis-off” modes of carbon arc operation during synthesis of carbon nanotubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yatom, Shurik; Selinsky, Rachel S.; Koel, Bruce E.

Arc discharge synthesis of single-walled carbon nanotubes (SWCNTs) remains largely uncontrollable, due to incomplete understanding of the synthetic process itself. Here, we show that synthesis of SWCNTs by a carbon arc may not constitute a single continuous process, but may instead consist of two distinct modes. One of these, a “synthesis-on” mode, produces the majority of the nanomaterials. During the synthesis-on mode, proportionally more carbon nanotubes are collected than in another mode, a “synthesis-off” mode. Both synthesis-on and synthesis-off modes for a typical arc configuration, employing a hollow anode filled with a mixture of powdered metal catalyst and graphite, weremore » characterized by using in situ electrical, imaging, and spectroscopic diagnostics, along with ex situ imaging and spectroscopy. The synthesis-on mode duration is rare compared to the total arc run-time, helping to explain the poor selectivity found in the final collected products, a known inadequacy of arc synthesis. Finally, the rarity of the synthesis on mode occurence may be due to the synthesis off mode being more favorable energetically.« less

“Synthesis-on” and “synthesis-off” modes of carbon arc operation during synthesis of carbon nanotubes

DOE PAGES

Yatom, Shurik; Selinsky, Rachel S.; Koel, Bruce E.; ...

2017-09-09

Arc discharge synthesis of single-walled carbon nanotubes (SWCNTs) remains largely uncontrollable, due to incomplete understanding of the synthetic process itself. Here, we show that synthesis of SWCNTs by a carbon arc may not constitute a single continuous process, but may instead consist of two distinct modes. One of these, a “synthesis-on” mode, produces the majority of the nanomaterials. During the synthesis-on mode, proportionally more carbon nanotubes are collected than in another mode, a “synthesis-off” mode. Both synthesis-on and synthesis-off modes for a typical arc configuration, employing a hollow anode filled with a mixture of powdered metal catalyst and graphite, weremore » characterized by using in situ electrical, imaging, and spectroscopic diagnostics, along with ex situ imaging and spectroscopy. The synthesis-on mode duration is rare compared to the total arc run-time, helping to explain the poor selectivity found in the final collected products, a known inadequacy of arc synthesis. Finally, the rarity of the synthesis on mode occurence may be due to the synthesis off mode being more favorable energetically.« less

Opportunities for improving maternal nutrition and birth outcomes: synthesis of country experiences.

PubMed

Mason, John B; Saldanha, Lisa S; Ramakrishnan, Usha; Lowe, Alyssa; Noznesky, Elizabeth A; Girard, Amy Webb; McFarland, Deborah A; Martorell, Reynaldo

2012-06-01

Undernutrition in women in poor countries remains prevalent and affects maternal, neonatal and child health (MNCH) outcomes. Improving MNCH outcomes requires better policies and programs that enhance women's nutrition. The studies aimed to better understand awareness, perceptions, barriers to intervention, and policy and program priorities and approaches, through different platforms, addressing three related priority problems: anemia, intra-uterine growth retardation (IUGR), and maternal thinness and stunting (including incomplete growth with early pregnancy). Results of a global literature review on program effectiveness, and from case studies in Ethiopia, India, and Nigeria, were synthesized. Anemia can be reduced by iron-folate supplementation, but all aspects for successful implementation, from priority to resources to local capacity, require strengthening. For IUGR, additional interventions, offood supplementation or cash transfers, may be required for impact, plus measures to combat early pregnancy. Breaking the intergenerational cycle of women's undernutrition may also be helped by child nutrition programs. Potential interventions exist and need to be built on: iron-folate and multiple micronutrient supplementation, food fortification (including iodized salt),food supplementation and/or cash transfer programs, combatting early pregnancy, infant and young child nutrition. Potential platforms are: the health system especially antenatal care, community-based nutrition programs (presently usually child-oriented but can be extended to women), child health days, safety net programs, especially cash transfer and conditional cash transfer programs. Making these more effective requires system development and organization, capacity and training, technical guidelines and operational research, and advocacy (who takes the lead?), information, monitoring and evaluation.

U.S. speeding-related motor vehicle fatalities by road function classification, 1995-1999

DOT National Transportation Integrated Search

2013-10-01

This document serves as an Operational Concept for the Applications for the Environment: Real-Time Information Synthesis (AERIS) Eco-Signal Operations Transformative Concept. It was developed along with two other Operational Concept documents that de...

Lesion-induced plasticity of high affinity choline uptake in the developing rat fascia dentata.

PubMed

Nadler, J V; Shelton, D L; Cotman, C W

1979-03-23

After removal of the perforant path input to the rat fascia dentata at the age of 11 days, cholinergic septohippocampal fibers invade the denervated area. We have examined the effect of this lesion on hemicholinium-sensitive, high affinity choline uptake and its coupling to acetylcholine synthesis, specific properties of the septohippocampal input. Removal of the ipsilateral perforant path fibers increased the velocity of high affinity choline uptake by dentate particulate preparations, usually within 1 day. Studies conducted 5--104 days after operation showed a consistent 50--65% elevation in the molecular (denervated) layer. In contrast, the choline uptake rate in the granular layer eventually decreased slightly. Calculation of choline uptake rates independently of protein (per whole region) revealed that fasciae dentatae from operated and control sides accumulated choline at approximately equal rates, but on the operated side a greater percentage was transported by structures from the molecular layer and a lesser percentage by those from the granular layer. The rate of acetylcholine synthesis from exogenous choline increased to the same extent as high affinity choline uptake from 3 days after operation onwards. The changes in high affinity choline uptake and acetylcholine synthesis coincided spatially and temporally with the reactive growth of septohippocampal fibers. Our results support the view that a perforant path lesion during development permanently alters the distribution of functional septohippocampal boutons in the fascia dentata. Acetylcholine synthesis is regulated to the same extent by high affinity choline uptake in the anomalous boutons as in normally located boutons.

Parametric synthesis of a robust controller on a base of mathematical programming method

NASA Astrophysics Data System (ADS)

Khozhaev, I. V.; Gayvoronskiy, S. A.; Ezangina, T. A.

2018-05-01

Considered paper is dedicated to deriving sufficient conditions, linking root indices of robust control quality with coefficients of interval characteristic polynomial, on the base of mathematical programming method. On the base of these conditions, a method of PI- and PID-controllers, providing aperiodic transient process with acceptable stability degree and, subsequently, acceptable setting time, synthesis was developed. The method was applied to a problem of synthesizing a controller for a depth control system of an unmanned underwater vehicle.

Indirect synthesis of multi-degree of freedom transient systems. [linear programming for a kinematically linear system

NASA Technical Reports Server (NTRS)

Pilkey, W. D.; Chen, Y. H.

1974-01-01

An indirect synthesis method is used in the efficient optimal design of multi-degree of freedom, multi-design element, nonlinear, transient systems. A limiting performance analysis which requires linear programming for a kinematically linear system is presented. The system is selected using system identification methods such that the designed system responds as closely as possible to the limiting performance. The efficiency is a result of the method avoiding the repetitive systems analyses accompanying other numerical optimization methods.

Application of Decision Tree to Obtain Optimal Operation Rules for Reservoir Flood Control Considering Sediment Desilting-Case Study of Tseng Wen Reservoir

NASA Astrophysics Data System (ADS)

ShiouWei, L.

2014-12-01

Reservoirs are the most important water resources facilities in Taiwan.However,due to the steep slope and fragile geological conditions in the mountain area,storm events usually cause serious debris flow and flood,and the flood then will flush large amount of sediment into reservoirs.The sedimentation caused by flood has great impact on the reservoirs life.Hence,how to operate a reservoir during flood events to increase the efficiency of sediment desilting without risk the reservoir safety and impact the water supply afterward is a crucial issue in Taiwan. 　Therefore,this study developed a novel optimization planning model for reservoir flood operation considering flood control and sediment desilting,and proposed easy to use operating rules represented by decision trees.The decision trees rules have considered flood mitigation,water supply and sediment desilting.The optimal planning model computes the optimal reservoir release for each flood event that minimum water supply impact and maximum sediment desilting without risk the reservoir safety.Beside the optimal flood operation planning model,this study also proposed decision tree based flood operating rules that were trained by the multiple optimal reservoir releases to synthesis flood scenarios.The synthesis flood scenarios consists of various synthesis storm events,reservoir's initial storage and target storages at the end of flood operating. 　Comparing the results operated by the decision tree operation rules(DTOR) with that by historical operation for Krosa Typhoon in 2007,the DTOR removed sediment 15.4% more than that of historical operation with reservoir storage only8.38×106m3 less than that of historical operation.For Jangmi Typhoon in 2008,the DTOR removed sediment 24.4% more than that of historical operation with reservoir storage only 7.58×106m3 less than that of historical operation.The results show that the proposed DTOR model can increase the sediment desilting efficiency and extend the reservoir life.

Geotechnology for low permeability gas reservoirs; [Progress report], April 1, 1992--September 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lorenz, J.C.; Warpinski, N.R.; Teufel, L.W.

The objectives of this program are (1) to use and refine a basinal analysis methodology for natural fracture exploration and exploitation, and (2) to determine the important characteritics of natural fracture systems for their use in completion, stimulation and production operations. Continuing work on this project has demonstrated that natural fracture systems and their flow characteristics can be defined by a thorough study of well and outcrop data within a basin. Outcrop data provides key information on fracture sets and lithologic controls, but some fracture sets found in the outcrop may not exist at depth. Well log and core datamore » provide the important reservoir information to obtain the correct synthesis of the fracture data. In situ stress information is then linked with the natural fracture studies to define permeability anisotropy and stimulation effectiveness. All of these elements require field data, and in the cases of logs, core, and well test data, the cooperation of an operator.« less

Stable synthesis of few-layered boron nitride nanotubes by anodic arc discharge.

PubMed

Yeh, Yao-Wen; Raitses, Yevgeny; Koel, Bruce E; Yao, Nan

2017-06-08

Boron nitride nanotubes (BNNTs) were successfully synthesized by a dc arc discharge using a boron-rich anode as synthesis feedstock in a nitrogen gas environment at near atmospheric pressure. The synthesis was achieved independent of the cathode material suggesting that under such conditions the arc operates in so-called anodic mode with the anode material being consumed by evaporation due to the arc heating. To sustain the arc current by thermionic electron emission, the cathode has to be at sufficiently high temperature, which for a typical arc current density of ~100 A/cm 2 , is above the boron melting point (2350 K). With both electrodes made from the same boron-rich alloy, we found that the arc operation unstable due to frequent sticking between two molten electrodes and formation of molten droplets. Stable and reliable arc operation and arc synthesis were achieved with the boron-rich anode and the cathode made from a refractory metal which has a melting temperature above the melting point of boron. Ex-situ characterization of synthesized BNNTs with electron microscopy and Raman spectroscopy revealed that independent of the cathode material, the tubes are primarily single and double walled. The results also show evidence of root-growth of BNNTs produced in the arc discharge.

Stable synthesis of few-layered boron nitride nanotubes by anodic arc discharge

DOE PAGES

Yeh, Yao-Wen; Raitses, Yevgeny; Koel, Bruce E.; ...

2017-06-08

Boron nitride nanotubes (BNNTs) were successfully synthesized by a dc arc discharge using a boron-rich anode as synthesis feedstock in a nitrogen gas environment at near atmospheric pressure. The synthesis was achieved independent of the cathode material suggesting that under such conditions the arc operates in so-called anodic mode with the anode material being consumed by evaporation due to the arc heating. In order to sustain the arc current by thermionic electron emission, the cathode has to be at sufficiently high temperature, which for a typical arc current density of similar to 100 A/cm 2, is above the boron meltingmore » point (2350 K). With both electrodes made from the same boron-rich alloy, we found that the arc operation unstable due to frequent sticking between two molten electrodes and formation of molten droplets. We achieved a stable and reliable arc operation and arc synthesis with the boronrich anode and the cathode made from a refractory metal which has a melting temperature above the melting point of boron. Ex-situ characterization of synthesized BNNTs with electron microscopy and Raman spectroscopy revealed that independent of the cathode material, the tubes are primarily single and double walled. Our results also show evidence of root-growth of BNNTs produced in the arc discharge.« less

Stable synthesis of few-layered boron nitride nanotubes by anodic arc discharge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yeh, Yao-Wen; Raitses, Yevgeny; Koel, Bruce E.

Boron nitride nanotubes (BNNTs) were successfully synthesized by a dc arc discharge using a boron-rich anode as synthesis feedstock in a nitrogen gas environment at near atmospheric pressure. The synthesis was achieved independent of the cathode material suggesting that under such conditions the arc operates in so-called anodic mode with the anode material being consumed by evaporation due to the arc heating. In order to sustain the arc current by thermionic electron emission, the cathode has to be at sufficiently high temperature, which for a typical arc current density of similar to 100 A/cm 2, is above the boron meltingmore » point (2350 K). With both electrodes made from the same boron-rich alloy, we found that the arc operation unstable due to frequent sticking between two molten electrodes and formation of molten droplets. We achieved a stable and reliable arc operation and arc synthesis with the boronrich anode and the cathode made from a refractory metal which has a melting temperature above the melting point of boron. Ex-situ characterization of synthesized BNNTs with electron microscopy and Raman spectroscopy revealed that independent of the cathode material, the tubes are primarily single and double walled. Our results also show evidence of root-growth of BNNTs produced in the arc discharge.« less

Intelligent transportation systems Professional Capacity Building Program needs assessment : a review and synthesis of thirteen studies

DOT National Transportation Integrated Search

1997-09-01

This report, ITS Professional Capacity Building: A Review and Synthesis of Thirteen Studies, serves as a companion report to ITS Professional Capacity Building: Field Interviews. This report summarizes what other organizations concerned about ITS sta...

A conceptual model of agroecosystem function as a basis for synthesis

USDA-ARS?s Scientific Manuscript database

A primary challenge for LTAR is to organize information about sustainable agricultural intensification such that it can be synthesized across multiple research programs addressing disparate problems. Such synthesis facilitates not only regional to national-scale generalizations to inform the public ...

High-Density Magnetic Recording and Integrated Magneto-Optics: Materials and Devices; Symposium Held in San Francisco, California, on April 12-16 1998

DTIC Science & Technology

1998-04-01

Kido •Solution Flow System for Hydrothermal -Electrochemical Synthesis : New Opportunities for Multilayered Oxide Films 639 VI. Suchanek, T...FLOW SYSTEM FOR HYDROTHERMAL -ELECTROCHEMICAL SYNTHESIS : NEW OPPORTUNITIES FOR MULTTLAYERED OXIDE FILMS W. SUCHANEK, T. WATANABE, B. SAKURAI, M...ABSTRACT A solution flow system for hydrothermal -electrochemical synthesis has been constructed in our laboratory. This equipment can operate at 20

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dagle, Robert A.; Lizarazo Adarme, Jair A.; Lebarbier, Vanessa MC

A composite Pd/ZnO/Al2O3-HZSM-5 (Si/Al=40) catalytic system was evaluated for the synthesis of gasoline-range hydrocarbons directly from synthesis gas. Bifunctional catalyst comprising PdZn metal and acid sites present the required catalytically active sites necessary for the methanol synthesis, methanol dehydration, and methanol-to-gasoline reactions. This system provides a unique catalytic pathway for the production of liquid hydrocarbons directly from syngas. However, selectivity control is difficult and poses many challenges. The composite catalytic system was evaluated under various process conditions. Investigated were the effects of temperature (310-375oC), pressure (300-1000 psig), time-on-stream (50 hrs), and gas-hour space velocity (740-2970 hr-1), using a H2/CO molarmore » syngas ratio of 2.0. By operating at the lower end of the temperature range investigated, liquid hydrocarbon formation was favored, as was decreased amounts of undesirable light hydrocarbons. However, lower operating temperatures also facilitated undesirable CO2 formation via the water-gas shift reaction. Higher operating pressures slightly favored liquid synthesis. Operating at relatively low pressures (e.g. 300 psig) was made possible, whereas for methanol synthesis alone higher pressure are usually required to achieve similar conversion levels (e.g. 1000 psig). Thermodynamic constraints on methanol synthesis are eased by pushing the equilibrium through hydrocarbon formation. Catalytic performance was also evaluated by altering Pd and Zn composition of the Pd/ZnO/Al2O3 catalyst. Of the catalysts and conditions tested, selectivity toward liquid hydrocarbon was highest when using a 5% Pd metal loading and Pd/Zn molar ratio of 0.25 and mixed with HZMS-5, operating at 310oC and 300 psig, CO conversion was 43 % and selectivity (carbon weight basis) to hydrocarbons was 49 wt. %. Of the hydrocarbon fraction, 44wt. % was in the C5-C12 liquid product range and consisted primarily of aromatic polymethylbenzenes. However, as syngas conversion increases with increasing temperature, selectivity to liquid product diminished. This is attributed, in large part, to increased saturation of the olefinic intermediates over PdZn metal sites. Under all the conditions and catalysts evaluated in this study, generating liquid product in high yield was challenging (<10 wt. % C5+ yield).« less

Derivation of sorting programs

NASA Technical Reports Server (NTRS)

Varghese, Joseph; Loganantharaj, Rasiah

1990-01-01

Program synthesis for critical applications has become a viable alternative to program verification. Nested resolution and its extension are used to synthesize a set of sorting programs from their first order logic specifications. A set of sorting programs, such as, naive sort, merge sort, and insertion sort, were successfully synthesized starting from the same set of specifications.

Space exploration initiative (SEI) logistics support lessons from the DoD

NASA Astrophysics Data System (ADS)

Cox, John R.; McCoy, Walbert G.; Jenkins, Terence

Proven and innovative logistics management approaches and techniques used for developing and supporting DoD and Strategic Defense Initiative Office (SDIO) systems are described on the basis of input from DoD to the SEI Synthesis Group; SDIO-developed logistics initiatives, innovative tools, and methodologies; and logistics planning support provided to the NASA/Johnson Planet Surface System Office. The approach is tailored for lunar/Martian surface operations, and provides guidelines for the development and management of a crucial element of the SEI logistics support program. A case study is presented which shows how incorporation of DoD's proven and innovative logistics management approach, tools, and techniques can substantially benefit early logistics planning for SEI, while also implementing many of DoD's recommendations for SEI.

Writing and compiling code into biochemistry.

PubMed

Shea, Adam; Fett, Brian; Riedel, Marc D; Parhi, Keshab

2010-01-01

This paper presents a methodology for translating iterative arithmetic computation, specified as high-level programming constructs, into biochemical reactions. From an input/output specification, we generate biochemical reactions that produce output quantities of proteins as a function of input quantities performing operations such as addition, subtraction, and scalar multiplication. Iterative constructs such as "while" loops and "for" loops are implemented by transferring quantities between protein types, based on a clocking mechanism. Synthesis first is performed at a conceptual level, in terms of abstract biochemical reactions - a task analogous to high-level program compilation. Then the results are mapped onto specific biochemical reactions selected from libraries - a task analogous to machine language compilation. We demonstrate our approach through the compilation of a variety of standard iterative functions: multiplication, exponentiation, discrete logarithms, raising to a power, and linear transforms on time series. The designs are validated through transient stochastic simulation of the chemical kinetics. We are exploring DNA-based computation via strand displacement as a possible experimental chassis.

Regulation of Dynamical Systems to Optimal Solutions of Semidefinite Programs: Algorithms and Applications to AC Optimal Power Flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dall'Anese, Emiliano; Dhople, Sairaj V.; Giannakis, Georgios B.

2015-07-01

This paper considers a collection of networked nonlinear dynamical systems, and addresses the synthesis of feedback controllers that seek optimal operating points corresponding to the solution of pertinent network-wide optimization problems. Particular emphasis is placed on the solution of semidefinite programs (SDPs). The design of the feedback controller is grounded on a dual e-subgradient approach, with the dual iterates utilized to dynamically update the dynamical-system reference signals. Global convergence is guaranteed for diminishing stepsize rules, even when the reference inputs are updated at a faster rate than the dynamical-system settling time. The application of the proposed framework to the controlmore » of power-electronic inverters in AC distribution systems is discussed. The objective is to bridge the time-scale separation between real-time inverter control and network-wide optimization. Optimization objectives assume the form of SDP relaxations of prototypical AC optimal power flow problems.« less

Noise suppression methods for robust speech processing

NASA Astrophysics Data System (ADS)

Boll, S. F.; Ravindra, H.; Randall, G.; Armantrout, R.; Power, R.

1980-05-01

Robust speech processing in practical operating environments requires effective environmental and processor noise suppression. This report describes the technical findings and accomplishments during this reporting period for the research program funded to develop real time, compressed speech analysis synthesis algorithms whose performance in invariant under signal contamination. Fulfillment of this requirement is necessary to insure reliable secure compressed speech transmission within realistic military command and control environments. Overall contributions resulting from this research program include the understanding of how environmental noise degrades narrow band, coded speech, development of appropriate real time noise suppression algorithms, and development of speech parameter identification methods that consider signal contamination as a fundamental element in the estimation process. This report describes the current research and results in the areas of noise suppression using the dual input adaptive noise cancellation using the short time Fourier transform algorithms, articulation rate change techniques, and a description of an experiment which demonstrated that the spectral subtraction noise suppression algorithm can improve the intelligibility of 2400 bps, LPC 10 coded, helicopter speech by 10.6 point.

AutoBayes Program Synthesis System Users Manual

NASA Technical Reports Server (NTRS)

Schumann, Johann; Jafari, Hamed; Pressburger, Tom; Denney, Ewen; Buntine, Wray; Fischer, Bernd

2008-01-01

Program synthesis is the systematic, automatic construction of efficient executable code from high-level declarative specifications. AutoBayes is a fully automatic program synthesis system for the statistical data analysis domain; in particular, it solves parameter estimation problems. It has seen many successful applications at NASA and is currently being used, for example, to analyze simulation results for Orion. The input to AutoBayes is a concise description of a data analysis problem composed of a parameterized statistical model and a goal that is a probability term involving parameters and input data. The output is optimized and fully documented C/C++ code computing the values for those parameters that maximize the probability term. AutoBayes can solve many subproblems symbolically rather than having to rely on numeric approximation algorithms, thus yielding effective, efficient, and compact code. Statistical analysis is faster and more reliable, because effort can be focused on model development and validation rather than manual development of solution algorithms and code.

NASA Fundamental Remote Sensing Science Research Program

NASA Technical Reports Server (NTRS)

1984-01-01

The NASA Fundamental Remote Sensing Research Program is described. The program provides a dynamic scientific base which is continually broadened and from which future applied research and development can draw support. In particular, the overall objectives and current studies of the scene radiation and atmospheric effect characterization (SRAEC) project are reviewed. The SRAEC research can be generically structured into four types of activities including observation of phenomena, empirical characterization, analytical modeling, and scene radiation analysis and synthesis. The first three activities are the means by which the goal of scene radiation analysis and synthesis is achieved, and thus are considered priority activities during the early phases of the current project. Scene radiation analysis refers to the extraction of information describing the biogeophysical attributes of the scene from the spectral, spatial, and temporal radiance characteristics of the scene including the atmosphere. Scene radiation synthesis is the generation of realistic spectral, spatial, and temporal radiance values for a scene with a given set of biogeophysical attributes and atmospheric conditions.

Insolubilized enzymes for food synthesis

NASA Technical Reports Server (NTRS)

Marshall, D. L.

1972-01-01

Cellulose matrix with numerous enzyme-coated silica particles of colloidal size permanently bound at various sites within matrix was produced that has high activity and possesses requisite physical characteristics for filtration or column operations. Product also allows coupling step in synthesis of edible food to proceed under mild conditions.

Synthesis of OECD work on environment and transport and survey of related OECD, IEA and ECMT activities

DOT National Transportation Integrated Search

2000-04-17

This document includes two related papers. The first, The Background and Synthesis Report, presents an overview of key conclusions and findings that can be derived from recent work by the Organisation for Economic Co-operation and Development (OECD) ...

Tolerance analysis program

NASA Technical Reports Server (NTRS)

Watson, H. K.

1971-01-01

Digital computer program determines tolerance values of end to end signal chain or flow path, given preselected probability value. Technique is useful in the synthesis and analysis phases of subsystem design processes.

Synthesis of Carbon Nanotubes in Thermal Plasma Reactor at Atmospheric Pressure.

PubMed

Szymanski, Lukasz; Kolacinski, Zbigniew; Wiak, Slawomir; Raniszewski, Grzegorz; Pietrzak, Lukasz

2017-02-18

In this paper, a novel approach to the synthesis of the carbon nanotubes (CNTs) in reactors operating at atmospheric pressure is presented. Based on the literature and our own research results, the most effective methods of CNT synthesis are investigated. Then, careful selection of reagents for the synthesis process is shown. Thanks to the performed calculations, an optimum composition of gases and the temperature for successful CNT synthesis in the CVD (chemical vapor deposition) process can be chosen. The results, having practical significance, may lead to an improvement of nanomaterials synthesis technology. The study can be used to produce CNTs for electrical and electronic equipment (i.e., supercapacitors or cooling radiators). There is also a possibility of using them in medicine for cancer diagnostics and therapy.

Zeolite catalysis in the synthesis of isobutylene from hydrous ethanol

NASA Astrophysics Data System (ADS)

Phillips, Cory Bernard

1999-11-01

This work deals with the synthesis of isobutylene from a hydrous ethanol feedstock over zeolites. The synthesis is accomplished in three steps: (1) low-temperature direct ethanol conversion to ethylene on H-ZSM-5 zeolite, (2) ethylene conversion to butene products over metal-exchanged zeolites, and (3) butene skeletal rearrangement to isobutylene over FER zeolites. The key to understanding and optimizing each synthesis step lies in the ability to control and regulate the zeolite acidity (Bronsted and Lewis)---both strength and number. Therefore, the continuous temperature programmed amine desorption (CTPAD) technique was further developed to simultaneously count the Bronsted acid sites and quantitatively characterize their strength. The adsorption of ethanol, reaction products, amines, coke and ethanol-derived residue (EDR) were monitored gravimetrically using the highly sensitive, novel Tapered Element Oscillating Microreactor (TEOM) apparatus. The TEOM was also used also in conjunction with CTPAD to characterize Bronsted acidity which is a new application for the instrument. For the first synthesis step, a parallel reaction exists which simultaneously produces diethyl ether and ethylene directly over H-ZSM-5. The reaction rates for each pathway were measured directly using a differential reactor operating at low temperatures (<473 K). Water in the ethanol feed enhances the rate of ethylene formation. A mechanism and kinetic expression are proposed for this reaction over H-ZSM-5, with diethyl-ether desorption and ethylene formation as the rate limiting steps. Heat of adsorption values measured from the independent microcalorimetry work reported in the literature are incorporated into the kinetic analysis which reduces the number of regressed parameters. For the remaining synthesis steps, several zeolite structures (ZSM-5, Y, FER) partially exchanged with Pd, Ti, Ni and Au were prepared and tested. It was determined from this screening study that the zeolites containing Pd are the most efficient catalysts for the dimerization reaction. Characterization results from x-ray diffraction (XRD), electron paramagnetic resonance (EPR) spectroscopy, and CTPAD suggest a stable, Pd species with a low oxidation state as part of the active site in Pd-exchanged zeolites. Isobutylene was present in the C4 fraction at reasonable quantities for most of the catalyst candidates, especially those containing an alkali metal co-cation.

Synthesis and toughness properties of resins and composites

NASA Technical Reports Server (NTRS)

Johnston, N. J.

1984-01-01

Tensile and shear moduli of four ACEE (Aircraft Energy Efficiency Program) resins are presented along with ACEE composite material modulus predictions based on micromechanics. Compressive strength and fracture toughness of the resins and composites were discussed. In addition, several resin synthesis techniques are reviewed.

[Synthesis of 107 Workplace Literacy Programs.

ERIC Educational Resources Information Center

Bussert, Kathy M.

A study examined information from 107 workplace literacy program descriptions from the United States and drew conclusions about joint partnerships, funding, and flexibility. Most of the program descriptions were found in an extensive search using the ERIC database. The programs described were from 1989 and 1990. Some of the findings were the…

On orbital allotments for geostationary satellites

NASA Technical Reports Server (NTRS)

Gonsalvez, David J. A.; Reilly, Charles H.; Mount-Campbell, Clark A.

1986-01-01

The following satellite synthesis problem is addressed: communication satellites are to be allotted positions on the geostationary arc so that interference does not exceed a given acceptable level by enforcing conservative pairwise satellite separation. A desired location is specified for each satellite, and the objective is to minimize the sum of the deviations between the satellites' prescribed and desired locations. Two mixed integer programming models for the satellite synthesis problem are presented. Four solution strategies, branch-and-bound, Benders' decomposition, linear programming with restricted basis entry, and a switching heuristic, are used to find solutions to example synthesis problems. Computational results indicate the switching algorithm yields solutions of good quality in reasonable execution times when compared to the other solution methods. It is demonstrated that the switching algorithm can be applied to synthesis problems with the objective of minimizing the largest deviation between a prescribed location and the corresponding desired location. Furthermore, it is shown that the switching heuristic can use no conservative, location-dependent satellite separations in order to satisfy interference criteria.

STC Synthesis of Best Practices for Determining Value of Research Results : Research Project Capsule

DOT National Transportation Integrated Search

2012-09-01

The RAC Region II has initiated a collaborative research program consortium : through the Transportation Pooled Fund (TPF) Program. The research program : is called the Southeast Transportation Consortium (STC) and is intended to : encourage coordina...

STC synthesis of research results for water quality management at construction sites : research project capsule.

DOT National Transportation Integrated Search

2012-07-01

The RAC Region II has initiated a collaborative research program consortium through the : Transportation Pooled Fund (TPF) Program. The research program is called the Southeast : Transportation Consortium (STC) and is intended to encourage coordinati...

Adding Concrete Syntax to a Prolog-Based Program Synthesis System

NASA Technical Reports Server (NTRS)

Fischer, Bernd; Visser, Eelco

2003-01-01

Program generation and transformation systems manipulate large, pa- rameterized object language fragments. Support for user-definable concrete syntax makes this easier but is typically restricted to certain object and meta languages. We show how Prolog can be retrofitted with concrete syntax and describe how a seamless interaction of concrete syntax fragments with an existing legacy meta-programming system based on abstract syntax is achieved. We apply the approach to gradually migrate the schemas of the AUTOBAYES program synthesis system to concrete syntax. Fit experiences show that this can result in a considerable reduction of the code size and an improved readability of the code. In particular, abstracting out fresh-variable generation and second-order term construction allows the formulation of larger continuous fragments and improves the locality in the schemas.

Thermolysis of Geminal Diazides: Reagent-Free Synthesis of 3-Hydroxypyridines.

PubMed

Erhardt, Hellmuth; Kunz, Kevin A; Kirsch, Stefan F

2017-01-06

An operationally simple protocol for the rapid and efficient construction of highly substituted 3-hydroxypyridines is presented. The thermally induced cyclization of easily constructed geminal diazides derived from β-ketoesters having an additional olefin moiety affords the title compounds in yields up to 97% under reagent-free conditions. The new method allows for the synthesis of preparative quantities of material. Additionally, the synthetic utility of the pyridine products for the synthesis of valuable heterocycles is described.

Synthesis gas and olefins from the catalytic autothermal reforming of volatile and non-volatile liquids

NASA Astrophysics Data System (ADS)

Dreyer, Bradon Justin

2007-12-01

The research presented in this thesis develops an understanding of a clean energy process technology, catalytic partial oxidation (CPO). CPO is a process in which a carbon containing fuel, such as a hydrocarbon, is passed over a noble metal catalyst (e.g. rhodium and platinum) to efficiently generate synthesis gas (H2 and CO) and olefins (e.g. ethylene and propylene) in millisecond contact times. Chapter 1 introduces CPO and compares this technology with conventional methods for synthesis gas and olefin production. CPO has several advantages over the traditional synthesis gas and olefin production methods. One advantage includes autothermal operation, requiring no external heat input from furnaces or heat exchangers. Autothermal operation allows these reactors to be built compactly. The short contact-times associated with CPO further enable for high throughput in relatively small reactor systems, and more compact reactors typically translate to faster response times if transient operation is required. Nobel metal based CPO catalysts are also resistant to deactivation, resulting in less catalyst replacement, regeneration, and maintenance, and an increase in operating efficiency. An overview of the many applications of the chemicals produced from CPO is also presented in Chapter 1. The chemicals produced are crucial in generating valuable chemical intermediates that are eventually incorporated in consumer products, medical devices, building structures, and fertilizers. Additionally, H2 can be used as a source of energy in mobile fuel applications. Fuel cells convert H2 and O2 into electricity and water at higher efficiencies than thermal engine generators. Due to the difficulties in H2 storage, these more efficient energy generators are dependent on hydrogen obtained from synthesis gas production in compact, portable fuel reformers, such as CPO reactors. Furthermore, H2 and CO can be used in reducing environmentally harmful emissions. Particularly, the implementation of NOx traps and hydrogen into diesel engines has shown potential in reducing NOx emissions into the environment. Both concepts are dependent on synthesis gas generated from portable, compact fuel reformers, such as CPO reactors. Chapter 1 also reviews previous research in CPO, along with several important experimental parameters, and outlines the remaining research directions in the remaining chapters. In Chapter 2, steam addition to the CPO of higher hydrocarbons was explored over rhodium-coated ceramic foam supports at millisecond contact times. Steam addition to the CPO of n-decane and n-hexadecane in air produced considerably higher H2 and CO2 and lower olefin and CO selectivities than traditional CPO. For steam to carbon feed ratios from 0.0 to 4.0, the reactor operated autothermally, and the H2 to CO product ratio increased from ˜1.0 to ˜4.0, which is essentially the equilibrium product composition near synthesis gas stoichiometry (C/O ˜1) at contact times of ˜7 milliseconds. In fuel-rich feeds exceeding the synthesis gas ratio (C/O > 1), steam addition suppressed olefins, promoted synthesis gas and water-gas shift products, and reduced catalyst surface carbon. Furthermore, steam addition to the CPO of the military fuel JP-8 was performed successfully, also increasing H2 and suppressing olefins. (Abstract shortened by UMI.)

Computer Synthesis Approaches of Hyperboloid Gear Drives with Linear Contact

NASA Astrophysics Data System (ADS)

Abadjiev, Valentin; Kawasaki, Haruhisa

2014-09-01

The computer design has improved forming different type software for scientific researches in the field of gearing theory as well as performing an adequate scientific support of the gear drives manufacture. Here are attached computer programs that are based on mathematical models as a result of scientific researches. The modern gear transmissions require the construction of new mathematical approaches to their geometric, technological and strength analysis. The process of optimization, synthesis and design is based on adequate iteration procedures to find out an optimal solution by varying definite parameters. The study is dedicated to accepted methodology in the creation of soft- ware for the synthesis of a class high reduction hyperboloid gears - Spiroid and Helicon ones (Spiroid and Helicon are trademarks registered by the Illinois Tool Works, Chicago, Ill). The developed basic computer products belong to software, based on original mathematical models. They are based on the two mathematical models for the synthesis: "upon a pitch contact point" and "upon a mesh region". Computer programs are worked out on the basis of the described mathematical models, and the relations between them are shown. The application of the shown approaches to the synthesis of commented gear drives is illustrated.

Cell-free protein synthesis: the state of the art.

PubMed

Whittaker, James W

2013-02-01

Cell-free protein synthesis harnesses the synthetic power of biology, programming the ribosomal translational machinery of the cell to create macromolecular products. Like PCR, which uses cellular replication machinery to create a DNA amplifier, cell-free protein synthesis is emerging as a transformative technology with broad applications in protein engineering, biopharmaceutical development, and post-genomic research. By breaking free from the constraints of cell-based systems, it takes the next step towards synthetic biology. Recent advances in reconstituted cell-free protein synthesis (Protein synthesis Using Recombinant Elements expression systems) are creating new opportunities to tailor the reactions for specialized applications including in vitro protein evolution, printing protein microarrays, isotopic labeling, and incorporating nonnatural amino acids.

Retrofitting the AutoBayes Program Synthesis System with Concrete Syntax

NASA Technical Reports Server (NTRS)

Fischer, Bernd; Visser, Eelco

2004-01-01

AutoBayes is a fully automatic, schema-based program synthesis system for statistical data analysis applications. Its core component is a schema library. i.e., a collection of generic code templates with associated applicability constraints which are instantiated in a problem-specific way during synthesis. Currently, AutoBayes is implemented in Prolog; the schemas thus use abstract syntax (i.e., Prolog terms) to formulate the templates. However, the conceptual distance between this abstract representation and the concrete syntax of the generated programs makes the schemas hard to create and maintain. In this paper we describe how AutoBayes is retrofitted with concrete syntax. We show how it is integrated into Prolog and describe how the seamless interaction of concrete syntax fragments with AutoBayes's remaining legacy meta-programming kernel based on abstract syntax is achieved. We apply the approach to gradually mitigate individual schemas without forcing a disruptive migration of the entire system to a different First experiences show that a smooth migration can be achieved. Moreover, it can result in a considerable reduction of the code size and improved readability of the code. In particular, abstracting out fresh-variable generation and second-order term construction allows the formulation of larger continuous fragments.

Key Scientific and Policy- and Health-Relevant Findings from EPA's Particulate Matter Supersites Program and Related Studies: An Integration and Synthesis of Results.

EPA Science Inventory

In 1998, the Environmental Protection Agency (EPA) initiated a major air quality program, known as the Particulate Matter (PM) Supersites Program. The Supersites Program was a multi year, $27 million air quality monitoring program consisting of eight regional air quality projects...

The Teaching of Protein Synthesis--A Microcomputer Based Method.

ERIC Educational Resources Information Center

Goodridge, Frank

1983-01-01

Describes two computer programs (BASIC for 32K Commodore PET) for teaching protein synthesis. The first is an interactive test of base-pairing knowledge, and the second generates random DNA nucleotide sequences, with instructions for substitution, insertion, and deletion printed out for each student. (JN)

Performance Analysis and Design Synthesis (PADS) computer program. Volume 2: Program description, part 2

NASA Technical Reports Server (NTRS)

1972-01-01

The QL module of the Performance Analysis and Design Synthesis (PADS) computer program is described. Execution of this module is initiated when and if subroutine PADSI calls subroutine GROPE. Subroutine GROPE controls the high level logical flow of the QL module. The purpose of the module is to determine a trajectory that satisfies the necessary variational conditions for optimal performance. The module achieves this by solving a nonlinear multi-point boundary value problem. The numerical method employed is described. It is an iterative technique that converges quadratically when it does converge. The three basic steps of the module are: (1) initialization, (2) iteration, and (3) culmination. For Volume 1 see N73-13199.

Best practices for achieving and measuring pavement smoothness, a synthesis of state-of-practice : [tech summary].

DOT National Transportation Integrated Search

2015-04-01

The RAC Region II has initiated a collaborative research program consortium : through the Transportation Pooled Fund (TPF) Program. The research program is : called the Southeast Transportation Consortium (STC) and is intended to encourage : coordina...

1,2-Dicyclopropylethyne and (Cyclopropylethynyl)cyclobutane from an Efficient Synthesis of 1,2-(omega-Haloalkyl)ethynes and 1-Cycloalkyl-2-(omega-haloalkyl)ethynes (Pre Print)

DTIC Science & Technology

2012-02-09

Efficient Synthesis of 1,2-(ω-Haloalkyl0ethynes and 1 -Cycloalkyl-2-(ω-haloalkyl)ethynes 5b. GRANT NUMBER (Pre Print) 5c. PROGRAM ELEMENT NUMBER...suffers from low yield as is evi- dent from the reported synthesis of 5-chloropent- 1 -yne (5, 57%)9 and 1,8-dichlorooct- 1 -yne (9, 36%).8 The synthesis ... chloropropane / 1 -bromo-4-chlorobutane is very sluggish and incomplete in THF. However, the reaction in the presence of 10 mol % Bu4NI results in an

GC/MS-based metabolomic studies reveal key roles of glycine in regulating silk synthesis in silkworm, Bombyx mori.

PubMed

Chen, Quanmei; Liu, Xinyu; Zhao, Ping; Sun, Yanhui; Zhao, Xinjie; Xiong, Ying; Xu, Guowang; Xia, Qingyou

2015-02-01

Metabolic profiling of silkworm, especially the factors that affect silk synthesis at the metabolic level, is little known. Herein, metabolomic method based on gas chromatography-mass spectrometry was applied to identify key metabolic changes in silk synthesis deficient silkworms. Forty-six differential metabolites were identified in Nd group with the defect of silk synthesis. Significant changes in the levels of glycine and uric acid (up-regulation), carbohydrates and free fatty acids (down-regulation) were observed. The further metabolomics of silk synthesis deficient silkworms by decreasing silk proteins synthesis using knocking out fibroin heavy chain gene or extirpating silk glands operation showed that the changes of the metabolites were almost consistent with those of the Nd group. Furthermore, the increased silk yields by supplying more glycine or its related metabolite confirmed that glycine is a key metabolite to regulate silk synthesis. These findings provide important insights into the regulation between metabolic profiling and silk synthesis. Copyright © 2014 Elsevier Ltd. All rights reserved.

The integrated manual and automatic control of complex flight systems

NASA Technical Reports Server (NTRS)

Schmidt, David K.

1991-01-01

Research dealt with the general area of optimal flight control synthesis for manned flight vehicles. The work was generic; no specific vehicle was the focus of study. However, the class of vehicles generally considered were those for which high authority, multivariable control systems might be considered, for the purpose of stabilization and the achievement of optimal handling characteristics. Within this scope, the topics of study included several optimal control synthesis techniques, control-theoretic modeling of the human operator in flight control tasks, and the development of possible handling qualities metrics and/or measures of merit. Basic contributions were made in all these topics, including human operator (pilot) models for multi-loop tasks, optimal output feedback flight control synthesis techniques; experimental validations of the methods developed, and fundamental modeling studies of the air-to-air tracking and flared landing tasks.

Germanium, Arsenic, and Selenium Abundances in Metal-poor Stars

NASA Astrophysics Data System (ADS)

Roederer, Ian U.

2012-09-01

The elements germanium (Ge, Z = 32), arsenic (As, Z = 33), and selenium (Se, Z = 34) span the transition from charged-particle or explosive synthesis of the iron-group elements to neutron-capture synthesis of heavier elements. Among these three elements, only the chemical evolution of germanium has been studied previously. Here we use archive observations made with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope and observations from several ground-based facilities to study the chemical enrichment histories of seven stars with metallicities -2.6 <= [Fe/H] <= -0.4. We perform a standard abundance analysis of germanium, arsenic, selenium, and several other elements produced by neutron-capture reactions. When combined with previous derivations of germanium abundances in metal-poor stars, our sample reveals an increase in the [Ge/Fe] ratios at higher metallicities. This could mark the onset of the weak s-process contribution to germanium. In contrast, the [As/Fe] and [Se/Fe] ratios remain roughly constant. These data do not directly indicate the origin of germanium, arsenic, and selenium at low metallicity, but they suggest that the weak and main components of the s-process are not likely sources. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained from the data archive at the Space Telescope Science Institute. STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. This research made use of StarCAT, hosted by the Mikulski Archive at the Space Telescope Science Institute (MAST). These data are associated with Programs GO-7348, GO-7433, GO-8197, GO-9048, GO-9455, and GO-9804.Based on data obtained from the European Southern Observatory (ESO) Science Archive Facility. These data are associated with Programs 67.D-0439(A), 074.C-0364(A), 076.B-0055(A), and 080.D-0347(A).This research has made use of the Keck Observatory Archive (KOA), which is operated by the W.M. Keck Observatory and the NASA Exoplanet Science Institute (NExScI), under contract with the National Aeronautics and Space Administration. These data are associated with Programs H2aH, H6aH, and H39aH (PI: Boesgaard), N01H (PI: Latham), and U11H (PI: Prochaska).This paper includes data taken at The McDonald Observatory of The University of Texas at Austin.

California's Past Programs to Support School and District Improvement: A Synthesis of Evaluation Studies

ERIC Educational Resources Information Center

California Collaborative on District Reform, 2017

2017-01-01

This document synthesizes the findings from the evaluations of four statewide programs designed to provide support for underperforming schools and districts in California as part of the state accountability system: (1) Immediate Intervention/Underperforming Schools Program (II/USP); (2) High Priority Schools Grant (HPSG) Program; (3) School…

Effective Programs for Elementary Science: A Best-Evidence Synthesis. Educator's Summary

ERIC Educational Resources Information Center

Center for Research and Reform in Education, 2012

2012-01-01

Which science programs have been proven to help elementary students to succeed? To find out, this review summarizes evidence on three types of programs designed to improve the science achievement of students in grades K-6: (1) Inquiry-oriented programs without science kits, such as Increasing Conceptual Challenge, Science IDEAS, and Collaborative…

U.S.-Based Short-Term Public Health Cultural Immersion Experience for Chinese Undergraduate Students

ERIC Educational Resources Information Center

Powell, Dorothy Lewis; Biederman, Donna J.

2017-01-01

A U.S. and Chinese university developed a short-term student exchange program in public/community health. The program--which consisted of lectures, seminars, field trips, cross-cultural experiences, and a synthesis excursion--resulted in high levels of program satisfaction, increased intrapersonal awareness, and skill acquisition. Program content…

A Program of Research and Education to Advance the Design, Synthesis, and Optimization of Aero-Space System Concepts

NASA Technical Reports Server (NTRS)

Sandusky, Robert

2002-01-01

Since its inception in December 1999, the program has provided support for a total of 11 Graduate Research Scholar Assistants, of these, 6 have completed their MS degree program. The program has generated 3 MS theses and a total of 4 publications/presentations.

Two-Swim Operators in the Modified Bacterial Foraging Algorithm for the Optimal Synthesis of Four-Bar Mechanisms

PubMed Central

Hernández-Ocaña, Betania; Pozos-Parra, Ma. Del Pilar; Mezura-Montes, Efrén; Portilla-Flores, Edgar Alfredo; Vega-Alvarado, Eduardo; Calva-Yáñez, Maria Bárbara

2016-01-01

This paper presents two-swim operators to be added to the chemotaxis process of the modified bacterial foraging optimization algorithm to solve three instances of the synthesis of four-bar planar mechanisms. One swim favors exploration while the second one promotes fine movements in the neighborhood of each bacterium. The combined effect of the new operators looks to increase the production of better solutions during the search. As a consequence, the ability of the algorithm to escape from local optimum solutions is enhanced. The algorithm is tested through four experiments and its results are compared against two BFOA-based algorithms and also against a differential evolution algorithm designed for mechanical design problems. The overall results indicate that the proposed algorithm outperforms other BFOA-based approaches and finds highly competitive mechanisms, with a single set of parameter values and with less evaluations in the first synthesis problem, with respect to those mechanisms obtained by the differential evolution algorithm, which needed a parameter fine-tuning process for each optimization problem. PMID:27057156

Two-Swim Operators in the Modified Bacterial Foraging Algorithm for the Optimal Synthesis of Four-Bar Mechanisms.

PubMed

Hernández-Ocaña, Betania; Pozos-Parra, Ma Del Pilar; Mezura-Montes, Efrén; Portilla-Flores, Edgar Alfredo; Vega-Alvarado, Eduardo; Calva-Yáñez, Maria Bárbara

2016-01-01

This paper presents two-swim operators to be added to the chemotaxis process of the modified bacterial foraging optimization algorithm to solve three instances of the synthesis of four-bar planar mechanisms. One swim favors exploration while the second one promotes fine movements in the neighborhood of each bacterium. The combined effect of the new operators looks to increase the production of better solutions during the search. As a consequence, the ability of the algorithm to escape from local optimum solutions is enhanced. The algorithm is tested through four experiments and its results are compared against two BFOA-based algorithms and also against a differential evolution algorithm designed for mechanical design problems. The overall results indicate that the proposed algorithm outperforms other BFOA-based approaches and finds highly competitive mechanisms, with a single set of parameter values and with less evaluations in the first synthesis problem, with respect to those mechanisms obtained by the differential evolution algorithm, which needed a parameter fine-tuning process for each optimization problem.

Synthesis of safety for traffic operations

DOT National Transportation Integrated Search

2003-03-01

Traffic operations practitioners are continually making decisions that impact on the safety performance of the transportation network. In order to make the best possible decisions the practitioner must be aware of the best available evidence on safet...

STC synthesis of real-time driver information for congestion management : research project capsule.

DOT National Transportation Integrated Search

2014-02-01

The main focus of this synthesis report is to compile a technical summary of past and current research, as : well as the state of the practice, on the role of real-time information in congestion mitigation programs. The : speci c objectives are to...

MPA-11: Materials Synthesis and Integrated Devices; Overview of an Applied Energy Group

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dattelbaum, Andrew Martin

Our mission is to provide innovative and creative chemical synthesis and materials science solutions to solve materials problems across the LANL missions. Our group conducts basic and applied research in areas related to energy security as well as problems relevant to the Weapons Program.

Distributed Drug Discovery: Advancing Chemical Education through Contextualized Combinatorial Solid-Phase Organic Laboratories

ERIC Educational Resources Information Center

Scott, William L.; Denton, Ryan E.; Marrs, Kathleen A.; Durrant, Jacob D.; Samaritoni, J. Geno; Abraham, Milata M.; Brown, Stephen P.; Carnahan, Jon M.; Fischer, Lindsey G.; Glos, Courtney E.; Sempsrott, Peter J.; O'Donnell, Martin J.

2015-01-01

The Distributed Drug Discovery (D3) program trains students in three drug discovery disciplines (synthesis, computational analysis, and biological screening) while addressing the important challenge of discovering drug leads for neglected diseases. This article focuses on implementation of the synthesis component in the second-semester…

Designing and Implementing a Capstone Gerontology Seminar: Synthesis and Action

ERIC Educational Resources Information Center

Sasser, Jennifer R.

2005-01-01

This paper focuses on the design and implementation of Gerontology: Synthesis and Action, the capstone seminar for the undergraduate and graduate certificate in gerontology program at Marylhurst University, a small, private liberal arts university in the Portland, Oregon metropolitan area. The institutional and programmatic context in which this…

Synthesis of calculational methods for design and analysis of radiation shields for nuclear rocket systems

NASA Technical Reports Server (NTRS)

Capo, M. A.; Disney, R. K.; Jordan, T. A.; Soltesz, R. G.; Woodsum, H. C.

1969-01-01

Eight computer programs make up a nine volume synthesis containing two design methods for nuclear rocket radiation shields. The first design method is appropriate for parametric and preliminary studies, while the second accomplishes the verification of a final nuclear rocket reactor design.

Lesbian, Gay, Bisexual, and Transgender Youth with Disabilities: A Meta-Synthesis

ERIC Educational Resources Information Center

Duke, Thomas Scott

2011-01-01

This meta-synthesis of empirical and nonempirical literature analyzed 24 journal articles and book chapters that addressed the intersection of disability, [homo]sexuality, and gender identity/expression in P-12 schools, colleges and universities, supported living programs, and other educational and social contexts in Australia, Belgium, Canada,…

Summer Synthesis Institutes: A Novel Approach for Transformative Research and Student Career Development

NASA Astrophysics Data System (ADS)

Wilson, J.; Hermans, C. M.

2010-12-01

It is believed that breakthroughs tend to occur when small groups of highly motivated scientists are driven by challenges encountered in real problem-solving situations and given the freedom to experiment with new ideas. Summer synthesis institutes provide a mechanism to facilitiate these breakthroughs and by which graduate students may engage in interdisciplinary research in a way that is not often available in their normal course of study. In this presentation we examine two complementary models of summer synthesis institutes in hydrology, how these intensive programs facilitate scientific outcomes and the impact of synthesis and the summer institute model on student perceptions of academic roles, collaboration opportunities and team science. Five summer synthesis institutes were held over three years, sharing similar duration and structure but different degrees of participant interdisciplinarity and focus questions. Through informal assessments, this presentation will demonstrate how these programs offered a unique opportunity for the development of student-student and student-mentor relationships and facilitated deeper understanding of a student’s own research as well as new techniques, perspective and disciplines. Additionally, though the summer synthesis institute model offers a unique ability to leverage limited funding (on the order of a single graduate student) to advance earth sciences, the model also presents specific challenges for research follow-through and may require specific content and interpersonal dynamics for optimum success.

Optimal Synthesis of the Joint Unitary Evolutions

NASA Astrophysics Data System (ADS)

Wei, Hai-Rui; Alsaedi, Ahmed; Hobiny, Aatef; Deng, Fu-Guo; Hu, Hui; Zhang, Dun

2018-07-01

Joint unitary operations play a central role in quantum communication and computation. We give a quantum circuit for implementing a type of unconstructed useful joint unitary evolutions in terms of controlled-NOT (CNOT) gates and single-qubit rotations. Our synthesis is optimal and possible in experiment. Two CNOT gates and seven R x , R y or R z rotations are required for our synthesis, and the arbitrary parameter contained in the evolutions can be controlled by local Hamiltonian or external fields.

Optimal Synthesis of the Joint Unitary Evolutions

NASA Astrophysics Data System (ADS)

Wei, Hai-Rui; Alsaedi, Ahmed; Hobiny, Aatef; Deng, Fu-Guo; Hu, Hui; Zhang, Dun

2018-03-01

Joint unitary operations play a central role in quantum communication and computation. We give a quantum circuit for implementing a type of unconstructed useful joint unitary evolutions in terms of controlled-NOT (CNOT) gates and single-qubit rotations. Our synthesis is optimal and possible in experiment. Two CNOT gates and seven R x , R y or R z rotations are required for our synthesis, and the arbitrary parameter contained in the evolutions can be controlled by local Hamiltonian or external fields.

Green chemistry for chemical synthesis

PubMed Central

Li, Chao-Jun; Trost, Barry M.

2008-01-01

Green chemistry for chemical synthesis addresses our future challenges in working with chemical processes and products by inventing novel reactions that can maximize the desired products and minimize by-products, designing new synthetic schemes and apparati that can simplify operations in chemical productions, and seeking greener solvents that are inherently environmentally and ecologically benign. PMID:18768813

Solid State Division progress report for period ending September 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, P.H.; Hinton, L.W.

1994-08-01

This report covers research progress in the Solid State Division from April 1, 1992, to September 30, 1993. During this period, the division conducted a broad, interdisciplinary materials research program with emphasis on theoretical solid state physics, neutron scattering, synthesis and characterization of materials, ion beam and laser processing, and the structure of solids and surfaces. This research effort was enhanced by new capabilities in atomic-scale materials characterization, new emphasis on the synthesis and processing of materials, and increased partnering with industry and universities. The theoretical effort included a broad range of analytical studies, as well as a new emphasismore » on numerical simulation stimulated by advances in high-performance computing and by strong interest in related division experimental programs. Superconductivity research continued to advance on a broad front from fundamental mechanisms of high-temperature superconductivity to the development of new materials and processing techniques. The Neutron Scattering Program was characterized by a strong scientific user program and growing diversity represented by new initiatives in complex fluids and residual stress. The national emphasis on materials synthesis and processing was mirrored in division research programs in thin-film processing, surface modification, and crystal growth. Research on advanced processing techniques such as laser ablation, ion implantation, and plasma processing was complemented by strong programs in the characterization of materials and surfaces including ultrahigh resolution scanning transmission electron microscopy, atomic-resolution chemical analysis, synchrotron x-ray research, and scanning tunneling microscopy.« less

Application of lean manufacturing concepts to drug discovery: rapid analogue library synthesis.

PubMed

Weller, Harold N; Nirschl, David S; Petrillo, Edward W; Poss, Michael A; Andres, Charles J; Cavallaro, Cullen L; Echols, Martin M; Grant-Young, Katherine A; Houston, John G; Miller, Arthur V; Swann, R Thomas

2006-01-01

The application of parallel synthesis to lead optimization programs in drug discovery has been an ongoing challenge since the first reports of library synthesis. A number of approaches to the application of parallel array synthesis to lead optimization have been attempted over the years, ranging from widespread deployment by (and support of) individual medicinal chemists to centralization as a service by an expert core team. This manuscript describes our experience with the latter approach, which was undertaken as part of a larger initiative to optimize drug discovery. In particular, we highlight how concepts taken from the manufacturing sector can be applied to drug discovery and parallel synthesis to improve the timeliness and thus the impact of arrays on drug discovery.

Computer Program for Point Location And Calculation of ERror (PLACER)

USGS Publications Warehouse

Granato, Gregory E.

1999-01-01

A program designed for point location and calculation of error (PLACER) was developed as part of the Quality Assurance Program of the Federal Highway Administration/U.S. Geological Survey (USGS) National Data and Methodology Synthesis (NDAMS) review process. The program provides a standard method to derive study-site locations from site maps in highwayrunoff, urban-runoff, and other research reports. This report provides a guide for using PLACER, documents methods used to estimate study-site locations, documents the NDAMS Study-Site Locator Form, and documents the FORTRAN code used to implement the method. PLACER is a simple program that calculates the latitude and longitude coordinates of one or more study sites plotted on a published map and estimates the uncertainty of these calculated coordinates. PLACER calculates the latitude and longitude of each study site by interpolating between the coordinates of known features and the locations of study sites using any consistent, linear, user-defined coordinate system. This program will read data entered from the computer keyboard and(or) from a formatted text file, and will write the results to the computer screen and to a text file. PLACER is readily transferable to different computers and operating systems with few (if any) modifications because it is written in standard FORTRAN. PLACER can be used to calculate study site locations in latitude and longitude, using known map coordinates or features that are identifiable in geographic information data bases such as USGS Geographic Names Information System, which is available on the World Wide Web.

Computer-Aided Communication Satellite System Analysis and Optimization.

ERIC Educational Resources Information Center

Stagl, Thomas W.; And Others

Various published computer programs for fixed/broadcast communication satellite system synthesis and optimization are discussed. The rationale for selecting General Dynamics/Convair's Satellite Telecommunication Analysis and Modeling Program (STAMP) in modified form to aid in the system costing and sensitivity analysis work in the Program on…

Computer Series, 60: Bits and Pieces, 23.

ERIC Educational Resources Information Center

Moore, John W., Ed.

1985-01-01

Describes: (1) an interactive computer simulation for a science fair display of chromatography inks; (2) analytical chemistry programs; (3) microcomputer-assisted drills in organic synthesis; (4) programs for conformation analysis of ethane and butane; (5) MOLPIX--a program for generating and displaying molecular structures; and (6) chemical…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aimthikul, Y.

This thesis reviews the essential aspects of speech synthesis and distinguishes between the two prevailing techniques: compressed digital speech and phonemic synthesis. It then presents the hardware details of the five speech modules evaluated. FORTRAN programs were written to facilitate message creation and retrieval with four of the modules driven by a PDP-11 minicomputer. The fifth module was driven directly by a computer terminal. The compressed digital speech modules (T.I. 990/306, T.S.I. Series 3D and N.S. Digitalker) each contain a limited vocabulary produced by the manufacturers while both the phonemic synthesizers made by Votrax permit an almost unlimited set ofmore » sounds and words. A text-to-phoneme rules program was adapted for the PDP-11 (running under the RSX-11M operating system) to drive the Votrax Speech Pac module. However, the Votrax Type'N Talk unit has its own built-in translator. Comparison of these modules revealed that the compressed digital speech modules were superior in pronouncing words on an individual basis but lacked the inflection capability that permitted the phonemic synthesizers to generate more coherent phrases. These findings were necessarily highly subjective and dependent on the specific words and phrases studied. In addition, the rapid introduction of new modules by manufacturers will necessitate new comparisons. However, the results of this research verified that all of the modules studied do possess reasonable quality of speech that is suitable for man-machine applications. Furthermore, the development tools are now in place to permit the addition of computer speech output in such applications.« less

Design of magnetic coordination complexes for quantum computing.

PubMed

Aromí, Guillem; Aguilà, David; Gamez, Patrick; Luis, Fernando; Roubeau, Olivier

2012-01-21

A very exciting prospect in coordination chemistry is to manipulate spins within magnetic complexes for the realization of quantum logic operations. An introduction to the requirements for a paramagnetic molecule to act as a 2-qubit quantum gate is provided in this tutorial review. We propose synthetic methods aimed at accessing such type of functional molecules, based on ligand design and inorganic synthesis. Two strategies are presented: (i) the first consists in targeting molecules containing a pair of well-defined and weakly coupled paramagnetic metal aggregates, each acting as a carrier of one potential qubit, (ii) the second is the design of dinuclear complexes of anisotropic metal ions, exhibiting dissimilar environments and feeble magnetic coupling. The first systems obtained from this synthetic program are presented here and their properties are discussed.

Purchase of Microwave Reactors for Implementation of Small-scale Microwave-accelerated Organic Chemistry Laboratory Program in Undergraduate Curriculum and Synthetic Chemistry Research at HU

DTIC Science & Technology

2015-05-16

synthesis of iron magnetic nanoparticles is being investigated (Appendix A; Scheme IV). In the first step, precursor iron(III) chloride nanoparticles...and other methods. Currently, we are developing a two-step scheme for the synthesis of esters that will require distillation and/or column...recognize the link between them. We are developing for the above purpose, the microwave-assisted, two-step synthesis of high boiling point esters. The

Alternative approximation concepts for space frame synthesis

NASA Technical Reports Server (NTRS)

Lust, R. V.; Schmit, L. A.

1985-01-01

A structural synthesis methodology for the minimum mass design of 3-dimensionall frame-truss structures under multiple static loading conditions and subject to limits on displacements, rotations, stresses, local buckling, and element cross-sectional dimensions is presented. A variety of approximation concept options are employed to yield near optimum designs after no more than 10 structural analyses. Available options include: (A) formulation of the nonlinear mathematcal programming problem in either reciprocal section property (RSP) or cross-sectional dimension (CSD) space; (B) two alternative approximate problem structures in each design space; and (C) three distinct assumptions about element end-force variations. Fixed element, design element linking, and temporary constraint deletion features are also included. The solution of each approximate problem, in either its primal or dual form, is obtained using CONMIN, a feasible directions program. The frame-truss synthesis methodology is implemented in the COMPASS computer program and is used to solve a variety of problems. These problems were chosen so that, in addition to exercising the various approximation concepts options, the results could be compared with previously published work.

Glucose Synthesis in a Protein-Based Artificial Photosynthesis System.

PubMed

Lu, Hao; Yuan, Wenqiao; Zhou, Jack; Chong, Parkson Lee-Gau

2015-09-01

The objective of this study was to understand glucose synthesis of a protein-based artificial photosynthesis system affected by operating conditions, including the concentrations of reactants, reaction temperature, and illumination. Results from non-vesicle-based glyceraldehyde-3-phosphate (GAP) and glucose synthesis showed that the initial concentrations of ribulose-1,5-bisphosphate (RuBP) and adenosine triphosphate (ATP), lighting source, and temperature significantly affected glucose synthesis. Higher initial concentrations of RuBP and ATP significantly enhanced GAP synthesis, which was linearly correlated to glucose synthesis, confirming the proper functions of all catalyzing enzymes in the system. White fluorescent light inhibited artificial photosynthesis and reduced glucose synthesis by 79.2 % compared to in the dark. The reaction temperature of 40 °C was optimum, whereas lower or higher temperature reduced glucose synthesis. Glucose synthesis in the vesicle-based artificial photosynthesis system reconstituted with bacteriorhodopsin, F 0 F 1 ATP synthase, and polydimethylsiloxane-methyloxazoline-polydimethylsiloxane triblock copolymer was successfully demonstrated. This system efficiently utilized light-induced ATP to drive glucose synthesis, and 5.2 μg ml(-1) glucose was synthesized in 0.78-ml reaction buffer in 7 h. Light-dependent reactions were found to be the bottleneck of the studied artificial photosynthesis system.

REVA CLIENT PARTNERSHIPS

EPA Science Inventory

EPA's Regional Vulnerability Assessment (ReVA) program is an applied research program that is focused on the synthesis and presentation of existing environmental data and model results to inform multicriteria environmental decision-making through a comprehensive analysis of infor...

Exploring the psychological health of emergency dispatch centre operatives: a systematic review and narrative synthesis.

PubMed

Golding, Sarah E; Horsfield, Claire; Davies, Annette; Egan, Bernadette; Jones, Martyn; Raleigh, Mary; Schofield, Patricia; Squires, Allison; Start, Kath; Quinn, Tom; Cropley, Mark

2017-01-01

The study objective was to investigate and synthesize available evidence relating to the psychological health of Emergency Dispatch Centre (EDC) operatives, and to identify key stressors experienced by EDC operatives. Eight electronic databases (Embase, PubMed, Medline, CINAHL, PsycInfo, PsycArticles, The Psychology and Behavioural Sciences Collection, and Google Scholar) were searched. All study designs were included, and no date limits were set. Studies were included if they were published in English, and explored the psychological health of any EDC operatives, across fire, police, and emergency medical services. Studies were excluded if they related solely to other emergency workers, such as police officers or paramedics. Methodological quality of included studies was assessed using checklists adapted from the Critical Appraisal Skills Programme. A narrative synthesis was conducted, using thematic analysis. A total of 16 articles were included in the review. Two overarching themes were identified during the narrative synthesis: 'Organisational and Operational Factors' and 'Interactions with Others'. Stressors identified included being exposed to traumatic calls, lacking control over high workload, and working in under-resourced and pressured environments. Lack of support from management and providing an emotionally demanding service were additional sources of stress. Peer support and social support from friends and family were helpful in managing work-related stress. EDC operatives experience stress as a result of their work, which appears to be related to negative psychological health outcomes. Future research should explore the long-term effects of this stress, and the potential for workplace interventions to alleviate the negative impacts on psychological health. CRD42014010806.

Synthesis of IES-Funded Research on Mathematics: 2002-2013. NCER 2016-2003

ERIC Educational Resources Information Center

Rittle-Johnson, Bethany; Jordan, Nancy C.

2016-01-01

The focus of the present synthesis reflects the research on programs, practices, and policies intended to improve mathematics outcomes funded through the Institute of Education Sciences' (IES's) National Center for Education Research (NCER) and National Center for Special Education Research (NCSER). The authors were asked to review those published…

Synthesis and characterization of hexaarylbenzenes with five or six different substituents enabled by programmed synthesis

NASA Astrophysics Data System (ADS)

Suzuki, Shin; Segawa, Yasutomo; Itami, Kenichiro; Yamaguchi, Junichiro

2015-03-01

Since its discovery in 1825, benzene has served as one of the most used and indispensable building blocks of chemical compounds, ranging from pharmaceuticals and agrochemicals to plastics and those used in organic electronic devices. Benzene has six hydrogen atoms that can each be replaced by different substituents, which means that the structural diversity of benzene derivatives is intrinsically extraordinary. The number of possible substituted benzenes from n different substituents is (2n + 2n2 + 4n3 + 3n4 + n6)/12. However, owing to a lack of general synthetic methods for making multisubstituted benzenes, this potentially huge structural diversity has not been fully exploited. Here, we describe a programmed synthesis of hexaarylbenzenes using C-H activation, cross-coupling and [4+2] cycloaddition reactions. The present method allows for the isolation and structure-property characterization of hexaarylbenzenes with distinctive aryl substituents at all positions for the first time. Moreover, the established protocol can be applied to the synthesis of tetraarylnaphthalenes and pentaarylpyridines.

Integrated programs for women with substance use issues and their children: a qualitative meta-synthesis of processes and outcomes.

PubMed

Sword, Wendy; Jack, Susan; Niccols, Alison; Milligan, Karen; Henderson, Joanna; Thabane, Lehana

2009-11-20

There is a need for services that effectively and comprehensively address the complex needs of women with substance use issues and their children. A growing body of literature supports the relevance of integrated treatment programs that offer a wide range of services in centralized settings. Quantitative studies suggest that these programs are associated with positive outcomes. A qualitative meta-synthesis was conducted to provide insight into the processes that contribute to recovery in integrated programs and women's perceptions of benefits for themselves and their children. A comprehensive search of published and unpublished literature to August 2009 was carried out for narrative reports of women's experiences and perceptions of integrated treatment programs. Eligibility for inclusion in the meta-synthesis was determined using defined criteria. Quality assessment was then conducted. Qualitative data and interpretations were extracted from studies of adequate quality, and were synthesized using a systematic and iterative process to create themes and overarching concepts. A total of 15 documents were included in the meta-synthesis. Women experienced a number of psychosocial processes during treatment that played a role in their recovery and contributed to favourable outcomes. These included: development of a sense of self; development of personal agency; giving and receiving of social support; engagement with program staff; self-disclosure of challenges, feelings, and past experiences; recognizing patterns of destructive behaviour; and goal setting. A final process, the motivating presence of children, sustained women in their recovery journeys. Perceived outcomes included benefits for maternal and child well-being, and enhanced parenting capacity. A number of distinct but interconnected processes emerged as being important to women's addiction recovery. Women experienced individual growth and transformative learning that led to a higher quality of life and improved interactions with their children. The findings support the need for programs to adopt practices that focus on improving maternal health and social functioning in an environment characterized by empowerment, safety, and connections. Women's relationships with their children require particular attention as positive parenting practices and family relationships can alter predispositions toward substance use later in life, thereby impacting favourably on the cycle of addiction and dysfunctional parenting.

Problems and Issues Across Institutions and Programs

Treesearch

Douglas Powell; Jim Wood

2006-01-01

The symposium identified the major barriers to collaboration among institutions and programs. This synthesis, while admittedly drawing from only a sample of the papers presented, provides a synoptic view of the major recurring themes voiced by participants.Several overarching statements were voiced. No one institution or one program in isolation can...

Exemplary Programs in Physics, Chemistry, Biology, and Earth Science.

ERIC Educational Resources Information Center

Yager, Robert E., Ed.

The 1982 Search for Excellence in Science Education project has identified 50 exemplary programs in physics, chemistry, biology, and earth science. Descriptions of four of these programs and the criteria used in their selection are presented. The first section reviews the direction established by Project Synthesis in searching for exemplary…

Data analysis for bus planning and monitoring

DOT National Transportation Integrated Search

2000-01-01

This synthesis report will be of interest to transit agency managers, their schedule and operations planning staffs and others that are responsible for information about systems operations and ridership. It will also be of interest to others who inte...

Development of a weight/sizing design synthesis computer program. Volume 2: Program Description

NASA Technical Reports Server (NTRS)

Garrison, J. M.

1973-01-01

The program for the computerized analysis of weight estimation relationships for those elements of the space shuttle vehicle which contribute a significant portion of the inert weight is discussed. A listing of each module and subroutine of the program is presented. Included are a generalized flow chart describing the subroutine linkage of the complete program and detailed flow charts for each subprogram.

Research on Spectroscopy, Opacity, and Atmospheres

NASA Technical Reports Server (NTRS)

Oliversen, Ronald (Technical Monitor); Kurucz, Robert L.

2004-01-01

I propose to continue providing observers with basic data for interpreting spectra from stars, novas, supernovas, clusters, and galaxies. These data will include allowed forbidden line lists both laboratory and computed, for the first five to ten ions of all atoms and for all relevant diatomic molecules. I will eventually expend to all ions of the first thirty elements to treat far UV end X-ray spectra, and for envelope opacities. I also include triatomic molecules providing by other researchers. I have made CDs with Partridge and Schwanke's water data for work on M stars.The luna data also serve as input to my model atmosphere and synthesis programs that generated energy distributions, photometry, limb darkening, and spectra that can be used for planning observations and for fitting observed spectra. The spectrum synthesis programs produce detailed plots with the line identified. Grids of stellar spectra can be used for radial velocity-, rotation-, or abundance templates and for population synthesis. I am fitting spectra of bright stars to test the data and to produce atlases to guide observer. For each star the whole spectrum is computed from the UV to the far IR. The line data, opacities, models, spectra, and programs are freely distributed on CDs and on my web site and represent a unique resource for many NASA programs.

New Approach to Synthesis of Powder and Composite Materials by Electron Beam. Part 1. Technological Features of the Process

NASA Astrophysics Data System (ADS)

Rudskoy, A. I.; Kondrat'ev, S. Yu.; Sokolov, Yu. A.

2016-05-01

Possibilities of electron beam synthesis of structural and tool composite materials are considered. It is shown that a novel process involving mathematical modeling of each individual operation makes it possible to create materials with programmable structure and predictable properties from granules of various specified chemical compositions and sizes.

Manufacturing of Smart Structures Using Fiber Placement Manufacturing Processes

NASA Technical Reports Server (NTRS)

Thomas, Matthew M.; Glowasky, Robert A.; McIlroy, Bruce E.; Story, Todd A.

1996-01-01

Smart structures research and development, with the ultimate aim of rapid commercial and military production of these structures, are at the forefront of the Synthesis and Processing of Intelligent Cost-Effective Structures (SPICES) program. As part of this ARPA-sponsored program, MDA-E is using fiber placement processes to manufacture integrated smart structure systems. These systems comprise advanced composite structures with embedded fiber optic sensors, shape memory alloys, piezoelectric actuators, and miniature accelerometers. Cost-effective approaches and solutions to smart material synthesis in the fiber-placement process, based upon integrated product development, are discussed herein.

The vehicle design evaluation program - A computer-aided design procedure for transport aircraft

NASA Technical Reports Server (NTRS)

Oman, B. H.; Kruse, G. S.; Schrader, O. E.

1977-01-01

The vehicle design evaluation program is described. This program is a computer-aided design procedure that provides a vehicle synthesis capability for vehicle sizing, external load analysis, structural analysis, and cost evaluation. The vehicle sizing subprogram provides geometry, weight, and balance data for aircraft using JP, hydrogen, or methane fuels. The structural synthesis subprogram uses a multistation analysis for aerodynamic surfaces and fuselages to develop theoretical weights and geometric dimensions. The parts definition subprogram uses the geometric data from the structural analysis and develops the predicted fabrication dimensions, parts material raw stock buy requirements, and predicted actual weights. The cost analysis subprogram uses detail part data in conjunction with standard hours, realization factors, labor rates, and material data to develop the manufacturing costs. The program is used to evaluate overall design effects on subsonic commercial type aircraft due to parameter variations.

Adapting realist synthesis methodology: The case of workplace harassment interventions.

PubMed

Carr, Tracey; Quinlan, Elizabeth; Robertson, Susan; Gerrard, Angie

2017-12-01

Realist synthesis techniques can be used to assess complex interventions by extracting and synthesizing configurations of contexts, mechanisms, and outcomes found in the literature. Our novel and multi-pronged approach to the realist synthesis of workplace harassment interventions describes our pursuit of theory to link macro and program level theories. After discovering the limitations of a dogmatic approach to realist synthesis, we adapted our search strategy and focused our analysis on a subset of data. We tailored our realist synthesis to understand how, why, and under what circumstances workplace harassment interventions are effective. The result was a conceptual framework to test our theory-based interventions and provide the basis for subsequent realist evaluation. Our experience documented in this article contributes to an understanding of how, under what circumstances, and with what consequences realist synthesis principles can be customized. Copyright © 2017 John Wiley & Sons, Ltd.

The digital code driven autonomous synthesis of ibuprofen automated in a 3D-printer-based robot

PubMed Central

Kitson, Philip J; Glatzel, Stefan

2016-01-01

An automated synthesis robot was constructed by modifying an open source 3D printing platform. The resulting automated system was used to 3D print reaction vessels (reactionware) of differing internal volumes using polypropylene feedstock via a fused deposition modeling 3D printing approach and subsequently make use of these fabricated vessels to synthesize the nonsteroidal anti-inflammatory drug ibuprofen via a consecutive one-pot three-step approach. The synthesis of ibuprofen could be achieved on different scales simply by adjusting the parameters in the robot control software. The software for controlling the synthesis robot was written in the python programming language and hard-coded for the synthesis of ibuprofen by the method described, opening possibilities for the sharing of validated synthetic ‘programs’ which can run on similar low cost, user-constructed robotic platforms towards an ‘open-source’ regime in the area of chemical synthesis. PMID:28144350

Review of present groundwater monitoring programs at the Nevada Test Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hershey, R.L.; Gillespie, D.

1993-09-01

Groundwater monitoring at the Nevada Test Site (NTS) is conducted to detect the presence of radionuclides produced by underground nuclear testing and to verify the quality and safety of groundwater supplies as required by the State of Nevada and federal regulations, and by U.S. Department of Energy (DOE) Orders. Groundwater is monitored at water-supply wells and at other boreholes and wells not specifically designed or located for traditional groundwater monitoring objectives. Different groundwater monitoring programs at the NTS are conducted by several DOE Nevada Operations Office (DOE/NV) contractors. Presently, these individual groundwater monitoring programs have not been assessed or administeredmore » under a comprehensive planning approach. Redundancy exists among the programs in both the sampling locations and the constituents analyzed. Also, sampling for certain radionuclides is conducted more frequently than required. The purpose of this report is to review the existing NTS groundwater monitoring programs and make recommendations for modifying the programs so a coordinated, streamlined, and comprehensive monitoring effort may be achieved by DOE/NV. This review will be accomplished in several steps. These include: summarizing the present knowledge of the hydrogeology of the NTS and the potential radionuclide source areas for groundwater contamination; reviewing the existing groundwater monitoring programs at the NTS; examining the rationale for monitoring and the constituents analyzed; reviewing the analytical methods used to quantify tritium activity; discussing monitoring network design criteria; and synthesizing the information presented and making recommendations based on the synthesis. This scope of work was requested by the DOE/NV Hydrologic Resources Management Program (HRMP) and satisfies the 1993 (fiscal year) HRMP Groundwater Monitoring Program Review task.« less

Active vibration control testing of the SPICES program: final demonstration article

NASA Astrophysics Data System (ADS)

Dunne, James P.; Jacobs, Jack H.

1996-05-01

The Synthesis and Processing of Intelligent Cost Effective Structures (SPICES) Program is a partnership program sponsored by the Advanced Research Projects Agency. The mission of the program is to develop cost effective material processing and synthesis technologies to enable new products employing active vibration suppression and control devices to be brought to market. The two year program came to fruition in 1995 through the fabrication of the final smart components and testing of an active plate combined with two trapezoidal rails, forming an active mount. Testing of the SPICES combined active mount took place at McDonnell Douglas facilities in St. Louis, MO, in October-December 1995. Approximately 15 dB reduction in overall response of a motor mounted on the active structure was achieved. Further details and results of the SPICES combined active mount demonstration testing are outlined. Results of numerous damping and control strategies that were developed and employed in the testing are presented, as well as aspects of the design and fabrication of the SPICES active mount components.

Camera-enabled techniques for organic synthesis

PubMed Central

Ingham, Richard J; O’Brien, Matthew; Browne, Duncan L

2013-01-01

Summary A great deal of time is spent within synthetic chemistry laboratories on non-value-adding activities such as sample preparation and work-up operations, and labour intensive activities such as extended periods of continued data collection. Using digital cameras connected to computer vision algorithms, camera-enabled apparatus can perform some of these processes in an automated fashion, allowing skilled chemists to spend their time more productively. In this review we describe recent advances in this field of chemical synthesis and discuss how they will lead to advanced synthesis laboratories of the future. PMID:23766820

The design of multirate digital control systems

NASA Technical Reports Server (NTRS)

Berg, M. C.

1986-01-01

The successive loop closures synthesis method is the only method for multirate (MR) synthesis in common use. A new method for MR synthesis is introduced which requires a gradient-search solution to a constrained optimization problem. Some advantages of this method are that the control laws for all control loops are synthesized simultaneously, taking full advantage of all cross-coupling effects, and that simple, low-order compensator structures are easily accomodated. The algorithm and associated computer program for solving the constrained optimization problem are described. The successive loop closures , optimal control, and constrained optimization synthesis methods are applied to two example design problems. A series of compensator pairs are synthesized for each example problem. The succesive loop closure, optimal control, and constrained optimization synthesis methods are compared, in the context of the two design problems.

Natural Products Synthesis: Enabling Tools to Penetrate Nature’s Secrets of Biogenesis and Biomechanism†

PubMed Central

Williams, Robert M.

2011-01-01

Selected examples from our laboratory of how synthetic technology platforms developed for the total synthesis of several disparate families of natural products was harnessed to penetrate biomechanistic and/or biosynthetic queries is discussed. Unexpected discoveries of biomechanistic reactivity and/or penetrating the biogenesis of naturally occurring substances were made possible through access to substances available only through chemical synthesis. Hypothesis-driven total synthesis programs are emerging as very useful conceptual templates for penetrating and exploiting the inherent reactivity of biologically active natural substances. In many instances, new enabling synthetic technologies were required to be developed. The examples demonstrate the often un-tapped richness of complex molecule synthesis to provide powerful tools to understand, manipulate and exploit Nature’s vast and creative palette of secondary metabolites. PMID:21438619

A Novel Implementation of Efficient Algorithms for Quantum Circuit Synthesis

NASA Astrophysics Data System (ADS)

Zeller, Luke

In this project, we design and develop a computer program to effectively approximate arbitrary quantum gates using the discrete set of Clifford Gates together with the T gate (π/8 gate). Employing recent results from Mosca et. al. and Giles and Selinger, we implement a decomposition scheme that outputs a sequence of Clifford, T, and Tt gates that approximate the input to within a specified error range ɛ. Specifically, the given gate is first rounded to an element of Z[1/2, i] with a precision determined by ɛ, and then exact synthesis is employed to produce the resulting gate. It is known that this procedure is optimal in approximating an arbitrary single qubit gate. Our program, written in Matlab and Python, can complete both approximate and exact synthesis of qubits. It can be used to assist in the experimental implementation of an arbitrary fault-tolerant single qubit gate, for which direct implementation isn't feasible.

Heterogeneous catalytic process for alcohol fuels from syngas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minahan, D.M.; Nagaki, D.A.

1995-12-31

This project is focused on the discovery and evaluation of novel heterogeneous catalyst for the production of oxygenated fuel enhancers from synthesis gas. Catalysts have been studied and optimized for the production of methanol and isobutanol mixtures which may be used for the downstream synthesis of MTBE or related oxygenates. Higher alcohols synthesis (HAS) from syngas was studied; the alcohols that are produced in this process may be used for the downstream synthesis of MTBE or related oxygenates. This work has resulted in the discovery of a catalyst system that is highly selective for isobutanol compared with the prior art.more » The catalysts operate at high temperature (400{degrees}C), and consist of a spinel oxide support (general formula AB{sub 2}O{sub 4}, where A=M{sup 2+} and B = M{sup 3+}), promoted with various other elements. These catalysts operate by what is believed to be an aldol condensation mechanism, giving a product mix of mainly methanol and isobutanol. In this study, the effect of product feed/recycle (methanol, ethanol. n-propanol, isopropanol, carbon dioxide and water) on the performance of 10-DAN-55 (spinel oxide based catalyst) at 400{degrees}C, 1000 psi, GHSV = 12,000 and syngas (H{sub 2}/CO) ratio = 1:2 (alcohol addition) and 1:1 (carbon dioxide and water addition) was studied. The effect of operation at high temperatures and pressures on the performance of an improved catalyst formulation was also examined.« less

Analysis of optimal phenotypic space using elementary modes as applied to Corynebacterium glutamicum

PubMed Central

Gayen, Kalyan; Venkatesh, KV

2006-01-01

Background Quantification of the metabolic network of an organism offers insights into possible ways of developing mutant strain for better productivity of an extracellular metabolite. The first step in this quantification is the enumeration of stoichiometries of all reactions occurring in a metabolic network. The structural details of the network in combination with experimentally observed accumulation rates of external metabolites can yield flux distribution at steady state. One such methodology for quantification is the use of elementary modes, which are minimal set of enzymes connecting external metabolites. Here, we have used a linear objective function subject to elementary modes as constraint to determine the fluxes in the metabolic network of Corynebacterium glutamicum. The feasible phenotypic space was evaluated at various combinations of oxygen and ammonia uptake rates. Results Quantification of the fluxes of the elementary modes in the metabolism of C. glutamicum was formulated as linear programming. The analysis demonstrated that the solution was dependent on the criteria of objective function when less than four accumulation rates of the external metabolites were considered. The analysis yielded feasible ranges of fluxes of elementary modes that satisfy the experimental accumulation rates. In C. glutamicum, the elementary modes relating to biomass synthesis through glycolysis and TCA cycle were predominantly operational in the initial growth phase. At a later time, the elementary modes contributing to lysine synthesis became active. The oxygen and ammonia uptake rates were shown to be bounded in the phenotypic space due to the stoichiometric constraint of the elementary modes. Conclusion We have demonstrated the use of elementary modes and the linear programming to quantify a metabolic network. We have used the methodology to quantify the network of C. glutamicum, which evaluates the set of operational elementary modes at different phases of fermentation. The methodology was also used to determine the feasible solution space for a given set of substrate uptake rates under specific optimization criteria. Such an approach can be used to determine the optimality of the accumulation rates of any metabolite in a given network. PMID:17038164

Synthesis of Trigeneration Systems: Sensitivity Analyses and Resilience

PubMed Central

Carvalho, Monica; Lozano, Miguel A.; Ramos, José; Serra, Luis M.

2013-01-01

This paper presents sensitivity and resilience analyses for a trigeneration system designed for a hospital. The following information is utilized to formulate an integer linear programming model: (1) energy service demands of the hospital, (2) technical and economical characteristics of the potential technologies for installation, (3) prices of the available utilities interchanged, and (4) financial parameters of the project. The solution of the model, minimizing the annual total cost, provides the optimal configuration of the system (technologies installed and number of pieces of equipment) and the optimal operation mode (operational load of equipment, interchange of utilities with the environment, convenience of wasting cogenerated heat, etc.) at each temporal interval defining the demand. The broad range of technical, economic, and institutional uncertainties throughout the life cycle of energy supply systems for buildings makes it necessary to delve more deeply into the fundamental properties of resilient systems: feasibility, flexibility and robustness. The resilience of the obtained solution is tested by varying, within reasonable limits, selected parameters: energy demand, amortization and maintenance factor, natural gas price, self-consumption of electricity, and time-of-delivery feed-in tariffs. PMID:24453881

Synthesis of trigeneration systems: sensitivity analyses and resilience.

PubMed

Carvalho, Monica; Lozano, Miguel A; Ramos, José; Serra, Luis M

2013-01-01

This paper presents sensitivity and resilience analyses for a trigeneration system designed for a hospital. The following information is utilized to formulate an integer linear programming model: (1) energy service demands of the hospital, (2) technical and economical characteristics of the potential technologies for installation, (3) prices of the available utilities interchanged, and (4) financial parameters of the project. The solution of the model, minimizing the annual total cost, provides the optimal configuration of the system (technologies installed and number of pieces of equipment) and the optimal operation mode (operational load of equipment, interchange of utilities with the environment, convenience of wasting cogenerated heat, etc.) at each temporal interval defining the demand. The broad range of technical, economic, and institutional uncertainties throughout the life cycle of energy supply systems for buildings makes it necessary to delve more deeply into the fundamental properties of resilient systems: feasibility, flexibility and robustness. The resilience of the obtained solution is tested by varying, within reasonable limits, selected parameters: energy demand, amortization and maintenance factor, natural gas price, self-consumption of electricity, and time-of-delivery feed-in tariffs.

Microwave power amplifiers based on AlGaN/GaN transistors with a two-dimensional electron gas

NASA Astrophysics Data System (ADS)

Vendik, O. G.; Vendik, I. B.; Tural'chuk, P. A.; Parnes, Ya. M.; Parnes, M. D.

2016-11-01

A technique for synthesis of microwave power amplifiers based on transistors with a AlGaN/GaN heterojunction is discussed. Special focus is on the development of a technique for synthesis of transformation circuits of the power amplifier to increase efficiency with a retained high output power. The use of independent matching at the harmonic frequencies and fundamental frequency makes it possible to control the attainable efficiency in a wide frequency band along with the total suppression of harmonics beyond the operational band. Microwave power amplifiers for operation at 4 and 9 GHz have been developed and experimentally investigated.

Development of a fixed bed gasifier model and optimal operating conditions determination

NASA Astrophysics Data System (ADS)

Dahmani, Manel; Périlhon, Christelle; Marvillet, Christophe; Hajjaji, Noureddine; Houas, Ammar; Khila, Zouhour

2017-02-01

The main objective of this study was to develop a fixed bed gasifier model of palm waste and to identify the optimal operating conditions to produce electricity from synthesis gas. First, the gasifier was simulated using Aspen PlusTM software. Gasification is a thermo-chemical process that has long been used, but it remains a perfectible technology. It means incomplete combustion of biomass solid fuel into synthesis gas through partial oxidation. The operating parameters (temperature and equivalence ratio (ER)) were thereafter varied to investigate their effect on the synthesis gas composition and to provide guidance for future research and development efforts in process design. The equivalence ratio is defined as the ratio of the amount of air actually supplied to the gasifier and the stoichiometric amount of air. Increasing ER decreases the production of CO and H2 and increases the production of CO2 and H2O while an increase in temperature increases the fraction of CO and H2. The results show that the optimum temperature to have a syngas able to be effectively used for power generation is 900°C and the optimum equivalence ratio is 0.1.

Occupational Therapy in Preschools: A Synthesis of Current Knowledge

ERIC Educational Resources Information Center

Jasmin, Emmanuelle; Gauthier, Anne; Julien, Marjorie; Hui, Caroline

2018-01-01

This paper presents a synthesis of current knowledge about occupational therapy in preschools (for 3-6 year olds) in order to provide a better understanding of this field of practice and to guide the implementation or programming of this service. In the literature, occupational therapy in preschools has been documented mainly in the USA. Results…

Program Aids Analysis And Optimization Of Design

NASA Technical Reports Server (NTRS)

Rogers, James L., Jr.; Lamarsh, William J., II

1994-01-01

NETS/ PROSSS (NETS Coupled With Programming System for Structural Synthesis) computer program developed to provide system for combining NETS (MSC-21588), neural-network application program and CONMIN (Constrained Function Minimization, ARC-10836), optimization program. Enables user to reach nearly optimal design. Design then used as starting point in normal optimization process, possibly enabling user to converge to optimal solution in significantly fewer iterations. NEWT/PROSSS written in C language and FORTRAN 77.

Promising Practices and Programs: Current Efforts and Future Directions

ERIC Educational Resources Information Center

Crisp, Gloria

2016-01-01

The final chapter of the issue provides a synthesis of the first eight chapters, offers conclusions and recommendations, and considers future directions regarding practices and programs with promise for high impact at community colleges around the country.

Doctoral Programs in Educational Leadership: A Duality Framework of Commonality and Differences

ERIC Educational Resources Information Center

Zirkel, Perry A.

2012-01-01

In recent years, doctoral programs in education leadership have been subject to notable criticism and proposals for reform. Starting with a synthesis of this criticism, this article focuses on the two primary constituencies--university faculty members who teach in such programs, and school superintendents, who are the leading practitioners such…

Effective Secondary Science Programs: A Best-Evidence Synthesis

ERIC Educational Resources Information Center

Cheung, Alan; Slavin, Robert E.; Kim, Elizabeth; Lake, Cynthia

2015-01-01

This article reports a systematic review of research on science programs in grades 6-12. Twenty-one studies met inclusion criteria including use of randomized or matched assignment to conditions, measures that assess content emphasized equally in experimental and control groups, and a duration of at least 12 weeks. Programs fell into four…

Effective Secondary Science Programs: A Best-Evidence Synthesis

ERIC Educational Resources Information Center

Cheung, Alan; Slavin, Robert E.; Kim, Elizabeth; Lake, Cynthia

2017-01-01

This article reports a systematic review of research on science programs in grades 6-12. Twenty-one studies met inclusion criteria including use of randomized or quasi-experimental assignment to conditions, measures that assess content emphasized equally in experimental and control groups, and a duration of at least 12 weeks. Programs fell into…

Occupational Safety and Health Programs in Career Education.

ERIC Educational Resources Information Center

DiCarlo, Robert D.; And Others

This resource guide was developed in response to the Occupational Safety and Health Act of 1970 and is intended to assist teachers in implementing courses in occupational safety and health as part of a career education program. The material is a synthesis of films, programed instruction, slides and narration, case studies, safety pamphlets,…

A Meta-Analysis of the Effects of Enrichment Programs on Gifted Students

ERIC Educational Resources Information Center

Kim, Mihyeon

2016-01-01

Although descriptions of enrichment programs are valuable for practitioners, practices, and services for gifted students, they must be backed by evidence, derived through a synthesis of research. This study examined research on enrichment programs serving gifted students and synthesized the current studies between 1985 and 2014 on the effects of…

Learning about and from a Distribution of Program Impacts Using Multisite Trials

ERIC Educational Resources Information Center

Raudenbush, Stephen W.; Bloom, Howard S.

2015-01-01

The present article provides a synthesis of the conceptual and statistical issues involved in using multisite randomized trials to learn about and from a distribution of heterogeneous program impacts across individuals and/or program sites. Learning "about" such a distribution involves estimating its mean value, detecting and quantifying…

System Analysis in Instructional Programming: The Initial Phases of the Program Construction Process.

ERIC Educational Resources Information Center

Bjerstedt, Ake

A three-volume series describes the construction of a self-instructional system as a work process with three main phases: system analysis, system synthesis, and system modification and evaluation. After an introductory discussion of some basic principles of instructional programing, this first volume focuses on the system analysis phase,…

An Evaluation of the Technical Adequacy of a Revised Measure of Quality Indicators of Transition

ERIC Educational Resources Information Center

Morningstar, Mary E.; Lee, Hyunjoo; Lattin, Dana L.; Murray, Angela K.

2016-01-01

This study confirmed the reliability and validity of the Quality Indicators of Exemplary Transition Programs Needs Assessment-2 (QI-2). Quality transition program indicators were identified through a systematic synthesis of transition research, policies, and program evaluation measures. To verify reliability and validity of the QI-2, we…

Building Better Bridges into STEM: A Synthesis of 25 Years of Literature on STEM Summer Bridge Programs

ERIC Educational Resources Information Center

Ashley, Michael; Cooper, Katelyn M.; Cala, Jacqueline M.; Brownell, Sara E.

2017-01-01

Summer bridge programs are designed to help transition students into the college learning environment. Increasingly, bridge programs are being developed in science, technology, engineering, and mathematics (STEM) disciplines because of the rigorous content and lower student persistence in college STEM compared with other disciplines. However, to…

ACCESS 3. Approximation concepts code for efficient structural synthesis: User's guide

NASA Technical Reports Server (NTRS)

Fleury, C.; Schmit, L. A., Jr.

1980-01-01

A user's guide is presented for ACCESS-3, a research oriented program which combines dual methods and a collection of approximation concepts to achieve excellent efficiency in structural synthesis. The finite element method is used for structural analysis and dual algorithms of mathematical programming are applied in the design optimization procedure. This program retains all of the ACCESS-2 capabilities and the data preparation formats are fully compatible. Four distinct optimizer options were added: interior point penalty function method (NEWSUMT); second order primal projection method (PRIMAL2); second order Newton-type dual method (DUAL2); and first order gradient projection-type dual method (DUAL1). A pure discrete and mixed continuous-discrete design variable capability, and zero order approximation of the stress constraints are also included.

The challenges and opportunities for integration of solar syngas production with liquid fuel synthesis

NASA Astrophysics Data System (ADS)

Hinkley, James T.; McNaughton, Robbie K.; Pye, John; Saw, Woei; Stechel, Ellen B.

2016-05-01

Reforming of methane is practiced on a vast scale globally for the production of syngas as a precursor for the production of many commodities, including hydrogen, ammonia and synthetic liquid fuels. Solar reforming can reduce the greenhouse gas intensity of syngas production by up to about 40% by using solar thermal energy to provide the endothermic heat of reaction, traditionally supplied by combustion of some of the feed. This has the potential to enable the production of solar derived synthetic fuels as drop in replacements for conventional fuels with significantly lower CO2 intensity than conventional gas to liquids (GTL) processes. However, the intermittent nature of the solar resource - both diurnal and seasonal - poses significant challenges for such a concept, which relies on synthesis processes that typically run continuously on very stable feed compositions. We find that the integration of solar syngas production to a GTL process is a non-trivial exercise, with the ability to turn down the capacity of the GTL synthesis section, and indeed to suspend operations for short periods without significant detriment to product quality or process operability, likely to be a key driver for the commercial implementation of solar liquid fuels. Projected costs for liquid fuel synthesis suggest that solar reforming and small scale gas to liquid synthesis can potentially compete with conventional oil derived transport fuels in the short to medium term.

Methodology for the specification of communication activities within the framework of a multi-layered architecture: Toward the definition of a knowledge base

NASA Astrophysics Data System (ADS)

Amyay, Omar

A method defined in terms of synthesis and verification steps is presented. The specification of the services and protocols of communication within a multilayered architecture of the Open Systems Interconnection (OSI) type is an essential issue for the design of computer networks. The aim is to obtain an operational specification of the protocol service couple of a given layer. Planning synthesis and verification steps constitute a specification trajectory. The latter is based on the progressive integration of the 'initial data' constraints and verification of the specification originating from each synthesis step, through validity constraints that characterize an admissible solution. Two types of trajectories are proposed according to the style of the initial specification of the service protocol couple: operational type and service supplier viewpoint; knowledge property oriented type and service viewpoint. Synthesis and verification activities were developed and formalized in terms of labeled transition systems, temporal logic and epistemic logic. The originality of the second specification trajectory and the use of the epistemic logic are shown. An 'artificial intelligence' approach enables a conceptual model to be defined for a knowledge base system for implementing the method proposed. It is structured in three levels of representation of the knowledge relating to the domain, the reasoning characterizing synthesis and verification activities and the planning of the steps of a specification trajectory.

Mg(OH)2 nanoparticles produced at room temperature by an innovative, facile, and scalable synthesis route

NASA Astrophysics Data System (ADS)

Taglieri, Giuliana; Felice, Benito; Daniele, Valeria; Ferrante, Fabiola

2015-10-01

Nanoparticles form the fundamental building blocks for many exciting applications in various scientific disciplines. However, the problem of the large-scale synthesis of nanoparticles remains challenging. An original, eco-friendly, single step, and scalable method to produce magnesium hydroxide nanoparticles in aqueous suspensions is here presented. The method, based on an exchange ion process, is extremely simple and rapid (few minutes). It employs cheap or renewable reactants, operates at room temperature and does not require intermediate steps (washings/purifications) to eliminate undesired compounds. Moreover, it is possible to regenerate the exchange material and to reuse it for new operation of synthesis, according to a cyclic procedure, providing potential aptitudes of scalability of nanoparticles production. Some of the synthesis parameters are varied, and structural and morphological features of the produced nanoparticles, after few seconds from the beginning of the synthesis up to the ending time, are investigated by means of several techniques, such as X-ray diffraction (profile fitting and Rietveld refinement), transmission electron microscopy, infrared spectroscopy, thermal analyses, and surface area measurements. In any case, pure and stable suspensions are produced, characterized by crystalline and mesoporous Mg(OH)2 nanoparticles, with lamellar morphology. In particular, the nanolamellas appeared constituted by a superimposition of hexagonally plated and crystalline nanosized precursors (2-3 nm in dimensions), crystallographically oriented.

Homogeneous catalyst formulations for methanol production

DOEpatents

Mahajan, Devinder; Sapienza, Richard S.; Slegeir, William A.; O'Hare, Thomas E.

1991-02-12

There is disclosed synthesis of CH.sub.3 OH from carbon monoxide and hydrogen using an extremely active homogeneous catalyst for methanol synthesis directly from synthesis gas. The catalyst operates preferably between 100.degree.-150.degree. C. and preferably at 100-150 psia synthesis gas to produce methanol. Use can be made of syngas mixtures which contain considerable quantities of other gases, such as nitrogen, methane or excess hydrogen. The catalyst is composed of two components: (a) a transition metal carbonyl complex and (b) an alkoxide component. In the simplest formulation, component (a) is a complex of nickel tetracarbonyl and component (b) is methoxide (CH.sub.3 O.sup.-), both being dissolved in a methanol solvent system. The presence of a co-solvent such as p-dioxane, THF, polyalcohols, ethers, hydrocarbons, and crown ethers accelerates the methanol synthesis reaction.

Homogeneous catalyst formulations for methanol production

DOEpatents

Mahajan, Devinder; Sapienza, Richard S.; Slegeir, William A.; O'Hare, Thomas E.

1990-01-01

There is disclosed synthesis of CH.sub.3 OH from carbon monoxide and hydrogen using an extremely active homogeneous catalyst for methanol synthesis directly from synthesis gas. The catalyst operates preferably between 100.degree.-150.degree. C. and preferably at 100-150 psia synthesis gas to produce methanol. Use can be made of syngas mixtures which contain considerable quantities of other gases, such as nitrogen, methane or excess hydrogen. The catalyst is composed of two components: (a) a transition metal carbonyl complex and (b) an alkoxide component. In the simplest formulation, component (a) is a complex of nickel tetracarbonyl and component (b) is methoxide (CH.sub.3 O.sup.13 ), both being dissolved in a methanol solvent system. The presence of a co-solvent such as p-dioxane, THF, polyalcohols, ethers, hydrocarbons, and crown ethers accelerates the methanol synthesis reaction.

A Formal Approach to Domain-Oriented Software Design Environments

NASA Technical Reports Server (NTRS)

Lowry, Michael; Philpot, Andrew; Pressburger, Thomas; Underwood, Ian; Lum, Henry, Jr. (Technical Monitor)

1994-01-01

This paper describes a formal approach to domain-oriented software design environments, based on declarative domain theories, formal specifications, and deductive program synthesis. A declarative domain theory defines the semantics of a domain-oriented specification language and its relationship to implementation-level subroutines. Formal specification development and reuse is made accessible to end-users through an intuitive graphical interface that guides them in creating diagrams denoting formal specifications. The diagrams also serve to document the specifications. Deductive program synthesis ensures that end-user specifications are correctly implemented. AMPHION has been applied to the domain of solar system kinematics through the development of a declarative domain theory, which includes an axiomatization of JPL's SPICELIB subroutine library. Testing over six months with planetary scientists indicates that AMPHION's interactive specification acquisition paradigm enables users to develop, modify, and reuse specifications at least an order of magnitude more rapidly than manual program development. Furthermore, AMPHION synthesizes one to two page programs consisting of calls to SPICELIB subroutines from these specifications in just a few minutes. Test results obtained by metering AMPHION's deductive program synthesis component are examined. AMPHION has been installed at JPL and is currently undergoing further refinement in preparation for distribution to hundreds of SPICELIB users worldwide. Current work to support end-user customization of AMPHION's specification acquisition subsystem is briefly discussed, as well as future work to enable domain-expert creation of new AMPHION applications through development of suitable domain theories.

A Study of Gaps in Network Knowledge Synthesis

DTIC Science & Technology

2016-10-14

Lincoln Laboratory MASSACHUSETTS INSTITUTE OF TECHNOLOGY LEXINGTON, MASSACHUSETTS Technical Report 1195 A Study of Gaps in Network...unlimited. This report is the result of studies performed at Lincoln Laboratory, a federally funded research and development center operated...specifically authorized by the U.S. Government may violate any copyrights that exist in this work. A Study of Gaps in Network Knowledge Synthesis

Accelerating spirocyclic polyketide synthesis using flow chemistry.

PubMed

Newton, Sean; Carter, Catherine F; Pearson, Colin M; de C Alves, Leandro; Lange, Heiko; Thansandote, Praew; Ley, Steven V

2014-05-05

Over the past decade, the integration of synthetic chemistry with flow processing has resulted in a powerful platform for molecular assembly that is making an impact throughout the chemical community. Herein, we demonstrate the extension of these tools to encompass complex natural product synthesis. We have developed a number of novel flow-through processes for reactions commonly encountered in natural product synthesis programs to achieve the first total synthesis of spirodienal A and the preparation of spirangien A methyl ester. Highlights of the synthetic route include an iridium-catalyzed hydrogenation, iterative Roush crotylations, gold-catalyzed spiroketalization and a late-stage cis-selective reduction. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

40 CFR 98.128 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... processing. An isolated intermediate is usually a product of chemical synthesis. Storage of an isolated... withdrawal of product do not occur simultaneously in a batch operation. Batch emission episode means a... process operations. By-product means a chemical that is produced coincidentally during the production of...

40 CFR 98.128 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... stored before subsequent processing. An isolated intermediate is usually a product of chemical synthesis... withdrawal of product do not occur simultaneously in a batch operation. Batch emission episode means a... process operations. By-product means a chemical that is produced coincidentally during the production of...

40 CFR 98.128 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... processing. An isolated intermediate is usually a product of chemical synthesis. Storage of an isolated... withdrawal of product do not occur simultaneously in a batch operation. Batch emission episode means a... process operations. By-product means a chemical that is produced coincidentally during the production of...

A high-level synthesis of oil spill response equipment and countermeasures.

PubMed

Ventikos, Nikolaos P; Vergetis, Emmanouil; Psaraftis, Harilaos N; Triantafyllou, George

2004-02-27

This paper presents an operational synthesis of major oil spill response methods (mechanical, chemical, etc.) and the corresponding oil response equipment for sea context (booms, skimmers, etc.). We focus on important features of oil spill response, in order to formulate a decision-based database, capable of supporting the development of a complete oil spill response operation. Moreover, we classify these findings and introduce simple formatting and standards to supply predictive tools for oil spill models. The actual goal of this paper is to come up with a decision-driven process, which can provide for a realistic choice of oil spill response equipment in the design of the primary oil response phase. This is intended to lead to a prompt, logical, and well-prepared oil spill response operation satisfying time and cost criteria and protecting the marine environment.

Conceptual design of distillation-based hybrid separation processes.

PubMed

Skiborowski, Mirko; Harwardt, Andreas; Marquardt, Wolfgang

2013-01-01

Hybrid separation processes combine different separation principles and constitute a promising design option for the separation of complex mixtures. Particularly, the integration of distillation with other unit operations can significantly improve the separation of close-boiling or azeotropic mixtures. Although the design of single-unit operations is well understood and supported by computational methods, the optimal design of flowsheets of hybrid separation processes is still a challenging task. The large number of operational and design degrees of freedom requires a systematic and optimization-based design approach. To this end, a structured approach, the so-called process synthesis framework, is proposed. This article reviews available computational methods for the conceptual design of distillation-based hybrid processes for the separation of liquid mixtures. Open problems are identified that must be addressed to finally establish a structured process synthesis framework for such processes.

Exploring the psychological health of emergency dispatch centre operatives: a systematic review and narrative synthesis

PubMed Central

Davies, Annette; Egan, Bernadette; Jones, Martyn; Raleigh, Mary; Schofield, Patricia; Squires, Allison; Start, Kath; Quinn, Tom

2017-01-01

Background The study objective was to investigate and synthesize available evidence relating to the psychological health of Emergency Dispatch Centre (EDC) operatives, and to identify key stressors experienced by EDC operatives. Methods Eight electronic databases (Embase, PubMed, Medline, CINAHL, PsycInfo, PsycArticles, The Psychology and Behavioural Sciences Collection, and Google Scholar) were searched. All study designs were included, and no date limits were set. Studies were included if they were published in English, and explored the psychological health of any EDC operatives, across fire, police, and emergency medical services. Studies were excluded if they related solely to other emergency workers, such as police officers or paramedics. Methodological quality of included studies was assessed using checklists adapted from the Critical Appraisal Skills Programme. A narrative synthesis was conducted, using thematic analysis. Results A total of 16 articles were included in the review. Two overarching themes were identified during the narrative synthesis: ‘Organisational and Operational Factors’ and ‘Interactions with Others’. Stressors identified included being exposed to traumatic calls, lacking control over high workload, and working in under-resourced and pressured environments. Lack of support from management and providing an emotionally demanding service were additional sources of stress. Peer support and social support from friends and family were helpful in managing work-related stress. Discussion EDC operatives experience stress as a result of their work, which appears to be related to negative psychological health outcomes. Future research should explore the long-term effects of this stress, and the potential for workplace interventions to alleviate the negative impacts on psychological health. PROSPERO Registration Number CRD42014010806. PMID:29062596

Synthesis of multi-loop automatic control systems by the nonlinear programming method

NASA Astrophysics Data System (ADS)

Voronin, A. V.; Emelyanova, T. A.

2017-01-01

The article deals with the problem of calculation of the multi-loop control systems optimal tuning parameters by numerical methods and nonlinear programming methods. For this purpose, in the paper the Optimization Toolbox of Matlab is used.

Cognitive Education with Deaf Adolescents: Effects of Instrumental Enrichment.

ERIC Educational Resources Information Center

Haywood, H. Carl; And Others

1988-01-01

Twenty-six deaf adolescents received instruction in a structured program of cognitive education called "Instrumental Enrichment." The program addresses, among other processes, comparison, classification, logical progression, spatial orientation, analysis and synthesis, and syllogistic thinking. Following training, the subjects showed…

How students process equations in solving quantitative synthesis problems? Role of mathematical complexity in students' mathematical performance

NASA Astrophysics Data System (ADS)

Ibrahim, Bashirah; Ding, Lin; Heckler, Andrew F.; White, Daniel R.; Badeau, Ryan

2017-12-01

We examine students' mathematical performance on quantitative "synthesis problems" with varying mathematical complexity. Synthesis problems are tasks comprising multiple concepts typically taught in different chapters. Mathematical performance refers to the formulation, combination, and simplification of equations. Generally speaking, formulation and combination of equations require conceptual reasoning; simplification of equations requires manipulation of equations as computational tools. Mathematical complexity is operationally defined by the number and the type of equations to be manipulated concurrently due to the number of unknowns in each equation. We use two types of synthesis problems, namely, sequential and simultaneous tasks. Sequential synthesis tasks require a chronological application of pertinent concepts, and simultaneous synthesis tasks require a concurrent application of the pertinent concepts. A total of 179 physics major students from a second year mechanics course participated in the study. Data were collected from written tasks and individual interviews. Results show that mathematical complexity negatively influences the students' mathematical performance on both types of synthesis problems. However, for the sequential synthesis tasks, it interferes only with the students' simplification of equations. For the simultaneous synthesis tasks, mathematical complexity additionally impedes the students' formulation and combination of equations. Several reasons may explain this difference, including the students' different approaches to the two types of synthesis problems, cognitive load, and the variation of mathematical complexity within each synthesis type.

Malleable architecture generator for FPGA computing

NASA Astrophysics Data System (ADS)

Gokhale, Maya; Kaba, James; Marks, Aaron; Kim, Jang

1996-10-01

The malleable architecture generator (MARGE) is a tool set that translates high-level parallel C to configuration bit streams for field-programmable logic based computing systems. MARGE creates an application-specific instruction set and generates the custom hardware components required to perform exactly those computations specified by the C program. In contrast to traditional fixed-instruction processors, MARGE's dynamic instruction set creation provides for efficient use of hardware resources. MARGE processes intermediate code in which each operation is annotated by the bit lengths of the operands. Each basic block (sequence of straight line code) is mapped into a single custom instruction which contains all the operations and logic inherent in the block. A synthesis phase maps the operations comprising the instructions into register transfer level structural components and control logic which have been optimized to exploit functional parallelism and function unit reuse. As a final stage, commercial technology-specific tools are used to generate configuration bit streams for the desired target hardware. Technology- specific pre-placed, pre-routed macro blocks are utilized to implement as much of the hardware as possible. MARGE currently supports the Xilinx-based Splash-2 reconfigurable accelerator and National Semiconductor's CLAy-based parallel accelerator, MAPA. The MARGE approach has been demonstrated on systolic applications such as DNA sequence comparison.

Sub-micron Cu/SSZ-13: Synthesis and application as selective catalytic reduction (SCR) catalysts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prodinger, Sebastian; Derewinski, Miroslaw A.; Wang, Yilin

For the first time, sub-micron Cu/SSZ-13, obtained by modifying an existing synthesis procedure, was shown to be an effective and stable catalyst for selective catalytic reduction reactions, such as NO reduction. Characterization of the materials with X-ray diffraction, N2-physisorption and 27Al MAS NMR shows that hydrothermal aging, simulating SCR reaction conditions, is more destructive in respect to dealumination for smaller particles prior to Cu-exchange. However, the catalytic performance and hydrothermal stability for Cu/SSZ-13 is independent of the particle size. In particular, the stability of tetrahedral framework Al is improved in the sub-micron Cu/SSZ-13 catalysts of comparable Cu loading. This indicatesmore » that variations in the Al distribution for different SSZ-13 synthesis procedures have a more critical influence on stabilizing isolated Cu-ions during harsh hydrothermal aging than the particle size. This study is of high interest for applications in vehicular DeNOx technologies where high loadings of active species on wash coats can be achieved by using sub-micron Cu/SSZ-13. The authors would like to thank B. W. Arey and J. J. Ditto for performing electron microscope imaging. The authors gratefully acknowledge the US Department of Energy (DOE), Energy Efficiency and Renewable Energy, Vehicle Technologies Office for the support of this work. S. P and M. A. D also acknowledge support by the Materials Synthesis and Simulation Across Scales (MS3 Initiative) conducted under the Laboratory Directed Research & Development Program at PNNL. The research described in this paper was performed in the Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by the DOE’s Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory (PNNL). PNNL is operated for the US DOE by Battelle.« less

How Do Contextual Factors Influence Implementation and Receipt of Positive Youth Development Programs Addressing Substance Use and Violence? A Qualitative Meta-Synthesis of Process Evaluations.

PubMed

Dickson, Kelly; Melendez-Torres, G J; Fletcher, Adam; Hinds, Kate; Thomas, James; Stansfield, Claire; Murphy, Simon; Campbell, Rona; Bonell, Chris

2018-05-01

Positive youth development (PYD) often aims to prevent tobacco, alcohol, and drugs use and violence. We systematically reviewed PYD interventions, synthesizing process, and outcomes evidence. Synthesis of outcomes, published elsewhere, found no overall evidence of reducing substance use or violence but notable variability of fidelity. Our synthesis of process evaluations examined how implementation varied and was influenced by context. Process evaluations of PYD aiming to reduce substance use and violence. Study Inclusion Criteria: Overall review published since 1985; written in English; focused on youth aged 11 to 18 years; focused on interventions addressing multiple positive assets; reported on theory, process, or outcomes; and concerned with reducing substance use or violence. Synthesis of process evaluations examined how implementation varies with or is influenced by context. Two reviewers in parallel. Thematic synthesis. We identified 12 reports. Community engagement enhanced program appeal. Collaboration with other agencies could broaden the activities offered. Calm but authoritative staff increased acceptability. Staff continuity underpinned diverse activities and durable relationships. Empowering participants were sometimes in tension with requiring them to engage in diverse activities. Our systematic review identified factors that might help improve the fidelity and acceptability of PYD interventions. Addressing these might enable PYD to fulfill its potential as a means of promoting health.

A synthesis of the "state-of-the-practice for advancing planning and operations integration opportunities within transportation agencies" : [summary].

DOT National Transportation Integrated Search

2014-12-01

Federal law requires that metropolitan transportation plans include operations and : management strategies to improve the performance of existing roads, relieve congestion, : and maximize the safety and mobility of people and cargo. Transportation op...

Applications for the environment : real-time information synthesis (AERIS) eco-signal operations : operational concept.

DOT National Transportation Integrated Search

2002-04-01

The Logical Architecture is based on a Computer Aided Systems Engineering (CASE) model of the requirements for the flow of data and control through the various functions included in Intelligent Transportation Systems (ITS). Data Dictionary is the com...

Low-voltage all-inorganic perovskite quantum dot transistor memory

NASA Astrophysics Data System (ADS)

Chen, Zhiliang; Zhang, Yating; Zhang, Heng; Yu, Yu; Song, Xiaoxian; Zhang, Haiting; Cao, Mingxuan; Che, Yongli; Jin, Lufan; Li, Yifan; Li, Qingyan; Dai, Haitao; Yang, Junbo; Yao, Jianquan

2018-05-01

An all-inorganic cesium lead halide quantum dot (QD) based Au nanoparticle (NP) floating-gate memory with a solution processed layer-by-layer method is demonstrated. Easy synthesis at room temperature and excellent stability make all-inorganic CsPbBr3 perovskite QDs suitable as a semiconductor layer in low voltage nonvolatile transistor memory. The bipolarity of QDs has both electrons and holes stored in the Au NP floating gate, resulting in bidirectional shifts of initial threshold voltage according to the applied programing and erasing pulses. Under low operation voltage (±5 V), the memory achieved a great memory window (˜2.4 V), long retention time (>105 s), and stable endurance properties after 200 cycles. So the proposed memory device based on CsPbBr3 perovskite QDs has a great potential in the flash memory market.

SYNTHESIS AND ASSESSMENT PRODUCT 4.6: ANALYSIS OF THE EFFECTS OF GLOBAL CHANGE ON HUMAN HEALTH AND WELFARE AND HUMAN SYSTEMS

EPA Science Inventory

This product is a report produced under the auspices of the United States Climate Change Science Program (CCSP). The report is one of the 21 synthesis and assessment products (SAPs) called for in the Strategic Plan of the CCSP to support policy making and adaptive management acr...

The Role of Reflection in Elementary Mathematics and Science Teachers' Training and Development: A Meta-Synthesis

ERIC Educational Resources Information Center

Saylor, Laura Lackner; Johnson, Carla C.

2014-01-01

Meaningful and effective training and professional development programs for teachers are key to the improvement of teaching practices in our schools. In this paper, the authors offer a meta-synthesis of the literature on the role of reflection for mathematics and science teachers within the context of professional development. The authors frame…

A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.

PubMed

Krokowski, Dawid; Han, Jaeseok; Saikia, Mridusmita; Majumder, Mithu; Yuan, Celvie L; Guan, Bo-Jhih; Bevilacqua, Elena; Bussolati, Ovidio; Bröer, Stefan; Arvan, Peter; Tchórzewski, Marek; Snider, Martin D; Puchowicz, Michelle; Croniger, Colleen M; Kimball, Scot R; Pan, Tao; Koromilas, Antonis E; Kaufman, Randal J; Hatzoglou, Maria

2013-06-14

Endoplasmic reticulum (ER) stress-induced responses are associated with the loss of insulin-producing β-cells in type 2 diabetes mellitus. β-Cell survival during ER stress is believed to depend on decreased protein synthesis rates that are mediated via phosphorylation of the translation initiation factor eIF2α. It is reported here that chronic ER stress correlated with increased islet protein synthesis and apoptosis in β-cells in vivo. Paradoxically, chronic ER stress in β-cells induced an anabolic transcription program to overcome translational repression by eIF2α phosphorylation. This program included expression of amino acid transporter and aminoacyl-tRNA synthetase genes downstream of the stress-induced ATF4-mediated transcription program. The anabolic response was associated with increased amino acid flux and charging of tRNAs for branched chain and aromatic amino acids (e.g. leucine and tryptophan), the levels of which are early serum indicators of diabetes. We conclude that regulation of amino acid transport in β-cells during ER stress involves responses leading to increased protein synthesis, which can be protective during acute stress but can lead to apoptosis during chronic stress. These studies suggest that the increased expression of amino acid transporters in islets can serve as early diagnostic biomarkers for the development of diabetes.

A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux*

PubMed Central

Krokowski, Dawid; Han, Jaeseok; Saikia, Mridusmita; Majumder, Mithu; Yuan, Celvie L.; Guan, Bo-Jhih; Bevilacqua, Elena; Bussolati, Ovidio; Bröer, Stefan; Arvan, Peter; Tchórzewski, Marek; Snider, Martin D.; Puchowicz, Michelle; Croniger, Colleen M.; Kimball, Scot R.; Pan, Tao; Koromilas, Antonis E.; Kaufman, Randal J.; Hatzoglou, Maria

2013-01-01

Endoplasmic reticulum (ER) stress-induced responses are associated with the loss of insulin-producing β-cells in type 2 diabetes mellitus. β-Cell survival during ER stress is believed to depend on decreased protein synthesis rates that are mediated via phosphorylation of the translation initiation factor eIF2α. It is reported here that chronic ER stress correlated with increased islet protein synthesis and apoptosis in β-cells in vivo. Paradoxically, chronic ER stress in β-cells induced an anabolic transcription program to overcome translational repression by eIF2α phosphorylation. This program included expression of amino acid transporter and aminoacyl-tRNA synthetase genes downstream of the stress-induced ATF4-mediated transcription program. The anabolic response was associated with increased amino acid flux and charging of tRNAs for branched chain and aromatic amino acids (e.g. leucine and tryptophan), the levels of which are early serum indicators of diabetes. We conclude that regulation of amino acid transport in β-cells during ER stress involves responses leading to increased protein synthesis, which can be protective during acute stress but can lead to apoptosis during chronic stress. These studies suggest that the increased expression of amino acid transporters in islets can serve as early diagnostic biomarkers for the development of diabetes. PMID:23645676

A computer program incorporating fatigue and fracture criteria in the preliminary design of transport aircraft: An evaluation

NASA Technical Reports Server (NTRS)

Berger, P. E.; Thornton, E. A.

1976-01-01

The APAS program a multistation structural synthesis procedure developed to evaluate material, geometry, and configuration with various design criteria usually considered for the primary structure of transport aircraft is described and evaluated. Recommendations to improve accuracy and extend the capabilities of the APAS program are given. Flow diagrams are included.

Supercritical synthesis of biodiesel.

PubMed

Bernal, Juana M; Lozano, Pedro; García-Verdugo, Eduardo; Burguete, M Isabel; Sánchez-Gómez, Gregorio; López-López, Gregorio; Pucheault, Mathieu; Vaultier, Michel; Luis, Santiago V

2012-07-23

The synthesis of biodiesel fuel from lipids (vegetable oils and animal fats) has gained in importance as a possible source of renewable non-fossil energy in an attempt to reduce our dependence on petroleum-based fuels. The catalytic processes commonly used for the production of biodiesel fuel present a series of limitations and drawbacks, among them the high energy consumption required for complex purification operations and undesirable side reactions. Supercritical fluid (SCF) technologies offer an interesting alternative to conventional processes for preparing biodiesel. This review highlights the advances, advantages, drawbacks and new tendencies involved in the use of supercritical fluids (SCFs) for biodiesel synthesis.

Tetraethylene glycol promoted two-step, one-pot rapid synthesis of indole-3-[1- 11C]acetic acid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Sojeong; Qu, Wenchao; Alexoff, David L.

2014-12-12

An operationally friendly, two-step, one-pot process has been developed for the rapid synthesis of carbon-11 labeled indole-3-acetic acid ([ 11]IAA or [ 11]auxin). By replacing an aprotic polar solvent with tetraethylene glycol, nucleophilic [ 11]cyanation and alkaline hydrolysis reactions were performed consecutively in a single pot without a time-consuming intermediate purification step. The entire production time for this updated procedure is 55 min, which dramatically simplifies the entire synthesis and reduces the starting radioactivity required for a whole plant imaging study.

Scenarios for Education in the Twenty-First Century: Synthesis of an Unfinished Dialogue and Questions for Further Progress

ERIC Educational Resources Information Center

Prospects: Quarterly Review of Comparative Education, 2004

2004-01-01

This article presents a synthesis of an unfinished dialogue on Organisation for Economic Co-operation and Development's (OECD) scenarios for education in the twenty-first century and on the position of education that these scenarios question. The first part of this article brings together some of the core considerations put forward by the members…

Review of literature and practices for incident management programs : technical report.

DOT National Transportation Integrated Search

2016-06-01

The project team examined project evaluations, best practice summaries, and synthesis documents, and derived a summary of key elements of programs to speed the time to find and clear stalled vehicles and crashes from freeway shoulders and main lanes....

Program Evaluation: A Review and Synthesis.

ERIC Educational Resources Information Center

Webber, Charles F.

This paper reviews models of program evaluation. Major topics and issues found in the evaluation literature include quantitative versus qualitative approaches, identification and involvement of stakeholders, formulation of research questions, collection of data, analysis and interpretation of data, reporting of results, evaluation utilization, and…

Novel synthesis approach for stable sodium superoxide (NaO2) nanoparticles for LPG sensing application

NASA Astrophysics Data System (ADS)

Nemade, Kailash; Waghuley, Sandeep

2017-05-01

The synthesis of stable superoxide is still great challenge for the researchers working in the field of materials science. Through this letter, we report the novel and simple synthesis approach for the preparation of stable sodium superoxide (NaO2) nanoparticles. NaO2 nanoparticles were prepared by a spray pyrolysis technique, under oxygen rich environment for gas sensing application. The texture characterizations show that as-obtained NaO2 nanoparticles have high structural purity. Most importantly, NaO2 nanoparticles exhibits higher sensing response, shorter response time and recovery time, low operating temperature and good stability during sensing of liquefied petroleum gas (LPG). The main accomplishment of present work is that as-fabricated sensor has low operating temperature (423 K), which is below auto-ignition temperature of LPG. The gas sensing mechanism of NaO2 nanoparticles was discussed without the conventional oxygen bridging mechanism. Through this short communication, LPG sensing application of stable sodium superoxide nanoparticle is explored.

Polyhydroxybutyrate synthesis on biodiesel wastewater using mixed microbial consortia.

PubMed

Dobroth, Zachary T; Hu, Shengjun; Coats, Erik R; McDonald, Armando G

2011-02-01

Crude glycerol (CG), a by-product of biodiesel production, is an organic carbon-rich substrate with potential as feedstock for polyhydroxyalkanoate (PHA) production. PHA is a biodegradable thermoplastic synthesized by microorganisms as an intracellular granule. In this study we investigated PHA production on CG using mixed microbial consortia (MMC) and determined that the enriched MMC produced exclusively polyhydroxybutyrate (PHB) utilizing the methanol fraction. PHB synthesis appeared to be stimulated by a macronutrient deficiency. Intracellular concentrations remained relatively constant over an operational cycle, with microbial growth occurring concurrent with polymer synthesis. PHB average molecular weights ranged from 200-380 kDa, while thermal properties compared well with commercial PHB. The resulting PHB material properties and characteristics would be suitable for many commercial uses. Considering full-scale process application, it was estimated that a 38 million L (10 million gallon) per year biodiesel operation could potentially produce up to 19 metric ton (20.9t on) of PHB per year. Copyright © 2010 Elsevier Ltd. All rights reserved.

The revised solar array synthesis computer program

NASA Technical Reports Server (NTRS)

1970-01-01

The Revised Solar Array Synthesis Computer Program is described. It is a general-purpose program which computes solar array output characteristics while accounting for the effects of temperature, incidence angle, charged-particle irradiation, and other degradation effects on various solar array configurations in either circular or elliptical orbits. Array configurations may consist of up to 75 solar cell panels arranged in any series-parallel combination not exceeding three series-connected panels in a parallel string and no more than 25 parallel strings in an array. Up to 100 separate solar array current-voltage characteristics, corresponding to 100 equal-time increments during the sunlight illuminated portion of an orbit or any 100 user-specified combinations of incidence angle and temperature, can be computed and printed out during one complete computer execution. Individual panel incidence angles may be computed and printed out at the user's option.

Using Decision Procedures to Build Domain-Specific Deductive Synthesis Systems

NASA Technical Reports Server (NTRS)

VanBaalen, Jeffrey; Roach, Steven; Lau, Sonie (Technical Monitor)

1998-01-01

This paper describes a class of decision procedures that we have found useful for efficient, domain-specific deductive synthesis. These procedures are called closure-based ground literal satisfiability procedures. We argue that this is a large and interesting class of procedures and show how to interface these procedures to a theorem prover for efficient deductive synthesis. Finally, we describe some results we have observed from our implementation. Amphion/NAIF is a domain-specific, high-assurance software synthesis system. It takes an abstract specification of a problem in solar system mechanics, such as 'when will a signal sent from the Cassini spacecraft to Earth be blocked by the planet Saturn?', and automatically synthesizes a FORTRAN program to solve it.

Computer-aided linear-circuit design.

NASA Technical Reports Server (NTRS)

Penfield, P.

1971-01-01

Usually computer-aided design (CAD) refers to programs that analyze circuits conceived by the circuit designer. Among the services such programs should perform are direct network synthesis, analysis, optimization of network parameters, formatting, storage of miscellaneous data, and related calculations. The program should be embedded in a general-purpose conversational language such as BASIC, JOSS, or APL. Such a program is MARTHA, a general-purpose linear-circuit analyzer embedded in APL.

Automated design synthesis of robotic/human workcells for improved manufacturing system design in hazardous environments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Joshua M.

Manufacturing tasks that are deemed too hazardous for workers require the use of automation, robotics, and/or other remote handling tools. The associated hazards may be radiological or nonradiological, and based on the characteristics of the environment and processing, a design may necessitate robotic labor, human labor, or both. There are also other factors such as cost, ergonomics, maintenance, and efficiency that also effect task allocation and other design choices. Handling the tradeoffs of these factors can be complex, and lack of experience can be an issue when trying to determine if and what feasible automation/robotics options exist. To address thismore » problem, we utilize common engineering design approaches adapted more for manufacturing system design in hazardous environments. We limit our scope to the conceptual and embodiment design stages, specifically a computational algorithm for concept generation and early design evaluation. In regard to concept generation, we first develop the functional model or function structure for the process, using the common 'verb-noun' format for describing function. A common language or functional basis for manufacturing was developed and utilized to formalize function descriptions and guide rules for function decomposition. Potential components for embodiment are also grouped in terms of this functional language and are stored in a database. The properties of each component are given as quantitative and qualitative criteria. Operators are also rated for task-relevant criteria which are used to address task compatibility. Through the gathering of process requirements/constraints, construction of the component database, and development of the manufacturing basis and rule set, design knowledge is stored and available for computer use. Thus, once the higher level process functions are defined, the computer can automate the synthesis of new design concepts through alternating steps of embodiment and function structure updates/decomposition. In the process, criteria guide function allocation of components/operators and help ensure compatibility and feasibility. Through multiple function assignment options and varied function structures, multiple design concepts are created. All of the generated designs are then evaluated based on a number of relevant evaluation criteria: cost, dose, ergonomics, hazards, efficiency, etc. These criteria are computed using physical properties/parameters of each system based on the qualities an engineer would use to make evaluations. Nuclear processes such as oxide conversion and electrorefining are utilized to aid algorithm development and provide test cases for the completed program. Through our approach, we capture design knowledge related to manufacturing and other operations in hazardous environments to enable a computational program to automatically generate and evaluate system design concepts.« less

49 CFR 1544.205 - Acceptance and screening of cargo.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Preventing or deterring the carriage of any explosive or incendiary. Each aircraft operator operating under a... operator operating under a full program or a full all-cargo program, or a twelve-five program in an all... program, before loading it on its aircraft. (c) Control. Each aircraft operator operating under a full...

Ambient-temperature NO oxidation over amorphous CrOx-ZrO 2 mixed oxide catalysts: Significant promoting effect of ZrO 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Aiyong; Guo, Yanglong; Gao, Feng

2017-03-01

Three series of Cr-based mixed oxides (Cr-Co, Cr-Fe, and Cr-Ni oxides) with high specific surface areas and amorphous textures are synthesized using a novel sol-gel method. These mixed oxides, in comparison to their pure metal oxide (CrOx, Co3O4, FeOx and NiO) counterparts, display enhanced performance for catalytic oxidation of low-concentration NO at room temperature. Over best performing catalysts, 100% NO conversion can be maintained up to 30 h of operation at a high space velocity of 45,000 ml g-1 h-1. The amorphous structure is found to be critical for these catalysts to maintain high activity and durability. Cr/M (M=Co, Femore » and Ni) molar ratio, nitrate precursor decomposition temperature and catalyst calcination temperature are important criteria for the synthesis of the highly active catalysts. This work was supported by National Basic Research Program of China (2013CB933200), National Natural Science Foundation of China (21577035, 21577034), Commission of Science and Technology of Shanghai Municipality (15DZ1205305) and 111 Project (B08021). Aiyong Wang gratefully acknowledges the China Scholarship Council for the Joint-Training Scholarship Program with the Pacific Northwest National Laboratory (PNNL). PNNL is operated for the U.S. Department of Energy (DOE) by Battelle. FG and CHFP are supported by the U.S. DOE/Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office.« less

40 CFR 72.72 - Criteria for State operating permit program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.72 Criteria for State operating permit program. A State operating permit program (including a State Acid Rain program) shall meet... withdrawal of all or part of the Acid Rain portion of an approved State operating permit program by the...

40 CFR 72.72 - Criteria for State operating permit program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.72 Criteria for State operating permit program. A State operating permit program (including a State Acid Rain program) shall meet... withdrawal of all or part of the Acid Rain portion of an approved State operating permit program by the...

40 CFR 72.72 - Criteria for State operating permit program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.72 Criteria for State operating permit program. A State operating permit program (including a State Acid Rain program) shall meet... withdrawal of all or part of the Acid Rain portion of an approved State operating permit program by the...

40 CFR 72.72 - Criteria for State operating permit program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.72 Criteria for State operating permit program. A State operating permit program (including a State Acid Rain program) shall meet... withdrawal of all or part of the Acid Rain portion of an approved State operating permit program by the...

40 CFR 72.72 - Criteria for State operating permit program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.72 Criteria for State operating permit program. A State operating permit program (including a State Acid Rain program) shall meet... withdrawal of all or part of the Acid Rain portion of an approved State operating permit program by the...

Effective Beginning Reading Programs: A Best-Evidence Synthesis

ERIC Educational Resources Information Center

Slavin, Robert E.; Lake, Cynthia; Chambers, Bette; Cheung, Alan; Davis, Susan

2009-01-01

This article systematically reviews research on the achievement outcomes of four types of approaches to improving the beginning reading success of children in kindergarten and first grade: Reading curricula, instructional technology, instructional process programs, and combinations of curricula and instructional process. Study inclusion criteria…

Assistive Technology and Adults with Learning Disabilities: A Blueprint for Exploration and Advancement.

ERIC Educational Resources Information Center

Raskind, Marshall

1993-01-01

This article describes assistive technologies for persons with learning disabilities, including word processing, spell checking, proofreading programs, outlining/"brainstorming" programs, abbreviation expanders, speech recognition, speech synthesis/screen review, optical character recognition systems, personal data managers, free-form databases,…

Family Involvement in School-Based Dysphagia Management

ERIC Educational Resources Information Center

Angell, Maureen E.; Bailey, Rita L.; Nicholson, Joanna K.; Stoner, Julia B.

2009-01-01

This article provides a practitioner-friendly synthesis of existing literature on family involvement in the management of dysphagia for school-age. Research reviewed includes family perspectives on programs, therapists, and characteristics that comprise effective family involvement in school-based dysphagia management programs. Also included are…

STRATEGIES TO REDUCE OR REPLACE THE USE OF ANIMALS IN THE ENDOCRINE SCREENING AND TESTING PROGRAM.

EPA Science Inventory

Abstract: The US Environmental Protection Agency (EPA) is developing a screening and testing program for endocrine disrupting chemicals (EDCs) to detect alterations of hypothalamic-pituitary-gonadal (HPG) function, estrogen, androgen and thyroid hormone synthesis and androgen (AR...

Practical multipeptide synthesis: dedicated software for the definition of multiple, overlapping peptides covering polypeptide sequences.

PubMed

Heegaard, P M; Holm, A; Hagerup, M

1993-01-01

A personal computer program for the conversion of linear amino acid sequences to multiple, small, overlapping peptide sequences has been developed. Peptide lengths and "jumps" (the distance between two consecutive overlapping peptides) are defined by the user. To facilitate the use of the program for parallel solid-phase chemical peptide syntheses for the synchronous production of multiple peptides, amino acids at each acylation step are laid out by the program in a convenient standard multi-well setup. Also, the total number of equivalents, as well as the derived amount in milligrams (depend-ending on user-defined equivalent weights and molar surplus), of each amino acid are given. The program facilitates the implementation of multipeptide synthesis, e.g., for the elucidation of polypeptide structure-function relationships, and greatly reduces the risk of introducing mistakes at the planning step. It is written in Pascal and runs on any DOS-based personal computer. No special graphic display is needed.

The use of automatic programming techniques for fault tolerant computing systems

NASA Technical Reports Server (NTRS)

Wild, C.

1985-01-01

It is conjectured that the production of software for ultra-reliable computing systems such as required by Space Station, aircraft, nuclear power plants and the like will require a high degree of automation as well as fault tolerance. In this paper, the relationship between automatic programming techniques and fault tolerant computing systems is explored. Initial efforts in the automatic synthesis of code from assertions to be used for error detection as well as the automatic generation of assertions and test cases from abstract data type specifications is outlined. Speculation on the ability to generate truly diverse designs capable of recovery from errors by exploring alternate paths in the program synthesis tree is discussed. Some initial thoughts on the use of knowledge based systems for the global detection of abnormal behavior using expectations and the goal-directed reconfiguration of resources to meet critical mission objectives are given. One of the sources of information for these systems would be the knowledge captured during the automatic programming process.

Deep embedding convolutional neural network for synthesizing CT image from T1-Weighted MR image.

PubMed

Xiang, Lei; Wang, Qian; Nie, Dong; Zhang, Lichi; Jin, Xiyao; Qiao, Yu; Shen, Dinggang

2018-07-01

Recently, more and more attention is drawn to the field of medical image synthesis across modalities. Among them, the synthesis of computed tomography (CT) image from T1-weighted magnetic resonance (MR) image is of great importance, although the mapping between them is highly complex due to large gaps of appearances of the two modalities. In this work, we aim to tackle this MR-to-CT synthesis task by a novel deep embedding convolutional neural network (DECNN). Specifically, we generate the feature maps from MR images, and then transform these feature maps forward through convolutional layers in the network. We can further compute a tentative CT synthesis from the midway of the flow of feature maps, and then embed this tentative CT synthesis result back to the feature maps. This embedding operation results in better feature maps, which are further transformed forward in DECNN. After repeating this embedding procedure for several times in the network, we can eventually synthesize a final CT image in the end of the DECNN. We have validated our proposed method on both brain and prostate imaging datasets, by also comparing with the state-of-the-art methods. Experimental results suggest that our DECNN (with repeated embedding operations) demonstrates its superior performances, in terms of both the perceptive quality of the synthesized CT image and the run-time cost for synthesizing a CT image. Copyright © 2018. Published by Elsevier B.V.

Systematic process synthesis and design methods for cost effective waste minimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biegler, L.T.; Grossman, I.E.; Westerberg, A.W.

We present progress on our work to develop synthesis methods to aid in the design of cost effective approaches to waste minimization. Work continues to combine the approaches of Douglas and coworkers and of Grossmann and coworkers on a hierarchical approach where bounding information allows it to fit within a mixed integer programming approach. We continue work on the synthesis of reactors and of flexible separation processes. In the first instance, we strive for methods we can use to reduce the production of potential pollutants, while in the second we look for ways to recover and recycle solvents.

Solar power satellite system definition study. Volume 3: Operations and systems synthesis, phase 2

NASA Technical Reports Server (NTRS)

1979-01-01

The results of the operations analyses are reported. Some of these analyses examined operations aspects of space vehicle in-space maintenance. Many of the analyses explored in great depth operations concerned the LEO Base cargo handling operations. Personnel transportation operations and cargo packaging were also analyzed. These operations analyses were performed to define the operational requirements for all of the SPS system elements so that equipment and facilities could be synthesized, and to make estimates of the manpower requirements. An overall, integrated, end-to-end description of the SPS operations is presented. The detailed operations analyses, upon which this integrated description was based, are included.

Molecular replication

NASA Technical Reports Server (NTRS)

Orgel, L. E.

1986-01-01

The object of our research program is to understand how polynucleotide replication originated on the primitive Earth. This is a central issue in studies of the origins of life, since a process similar to modern DNA and RNA synthesis is likely to have formed the basis for the most primitive system of genetic information transfer. The major conclusion of studies so far is that a preformed polynucleotide template under many different experimental conditions will facilitate the synthesis of a new oligonucleotide with a sequence complementary to that of the template. It has been shown, for example, that poly(C) facilitates the synthesis of long oligo(G)s and that the short template CCGCC facilities the synthesis of its complement GGCGG. Very recently we have shown that template-directed synthesis is not limited to the standard oligonucleotide substrates. Nucleic acid-like molecules with a pyrophosphate group replacing the phosphate of the standard nucleic acid backbone are readily synthesized from deoxynucleotide 3'-5'-diphosphates on appropriate templates.

Guide for Operational Configuration Management Program including the adjunct programs of design reconstitution and material condition and aging management. Part 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This standard presents program criteria and implementation guidance for an operational configuration management program for DOE nuclear and non-nuclear facilities in the operational phase. Portions of this standard are also useful for other DOE processes, activities, and programs. This Part 1 contains foreword, glossary, acronyms, bibliography, and Chapter 1 on operational configuration management program principles. Appendices are included on configuration management program interfaces, and background material and concepts for operational configuration management.

THRESHOLD LOGIC IN ARTIFICIAL INTELLIGENCE

DTIC Science & Technology

COMPUTER LOGIC, ARTIFICIAL INTELLIGENCE , BIONICS, GEOMETRY, INPUT OUTPUT DEVICES, LINEAR PROGRAMMING, MATHEMATICAL LOGIC, MATHEMATICAL PREDICTION, NETWORKS, PATTERN RECOGNITION, PROBABILITY, SWITCHING CIRCUITS, SYNTHESIS

The relative contribution of genes operating in the S-methylmethionine cycle to methionine metabolism in Arabidopsis seeds.

PubMed

Cohen, Hagai; Salmon, Asaf; Tietel, Zipora; Hacham, Yael; Amir, Rachel

2017-05-01

Enzymes operating in the S -methylmethionine cycle make a differential contribution to methionine synthesis in seeds. In addition, mutual effects exist between the S -methylmethionine cycle and the aspartate family pathway in seeds. Methionine, a sulfur-containing amino acid, is a key metabolite in plant cells. The previous lines of evidence proposed that the S-methylmethionine (SMM) cycle contributes to methionine synthesis in seeds where methionine that is produced in non-seed tissues is converted to SMM and then transported via the phloem into the seeds. However, the relative regulatory roles of the S-methyltransferases operating within this cycle in seeds are yet to be fully understood. In the current study, we generated transgenic Arabidopsis seeds with altered expression of three HOMOCYSTEINE S-METHYLTRANSFERASEs (HMTs) and METHIONINE S-METHYLTRANSFERASE (MMT), and profiled them for transcript and metabolic changes. The results revealed that AtHMT1 and AtHMT3, but not AtHMT2 and AtMMT, are the predominant enzymes operating in seeds as altered expression of these two genes affected the levels of methionine and SMM in transgenic seeds. Their manipulations resulted in adapted expression level of genes participating in methionine synthesis through the SMM and aspartate family pathways. Taken together, our findings provide new insights into the regulatory roles of the SMM cycle and the mutual effects existing between the two methionine biosynthesis pathways, highlighting the complexity of the metabolism of methionine and SMM in seeds.

50 CFR 253.18 - Program operating guidelines.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Program operating guidelines. 253.18 Section 253.18 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... Guarantee Program § 253.18 Program operating guidelines. The Division may issue Program operating guidelines...

Social science to improve fuels management: a synthesis of research relevant to communicating with homeowners about fuels management

Treesearch

Martha C. Monroe; Lisa Pennisi; Sarah McCaffrey; Dennis Mileti

2006-01-01

A series of syntheses were commissioned by the USDA Forest Service to aid in fuels mitigation project planning. This synthesis focuses on how managers can most effectively communicate with the public about fuels management efforts. It summarizes what is known about the techniques of persuasive communication programs and provides an outline of the characteristics of...

Aircraft interior noise prediction using a structural-acoustic analogy in NASTRAN modal synthesis

NASA Technical Reports Server (NTRS)

Grosveld, Ferdinand W.; Sullivan, Brenda M.; Marulo, Francesco

1988-01-01

The noise induced inside a cylindrical fuselage model by shaker excitation is investigated theoretically and experimentally. The NASTRAN modal-synthesis program is used in the theoretical analysis, and the predictions are compared with experimental measurements in extensive graphs. Good general agreement is obtained, but the need for further refinements to account for acoustic-cavity damping and structural-acoustic interaction is indicated.

A review and assessment of hydrodynamic cavitation as a technology for the future.

PubMed

Gogate, Parag R; Pandit, Aniruddha B

2005-01-01

In the present work, the current status of the hydrodynamic cavitation reactors has been reviewed discussing the bubble dynamics analysis, optimum design considerations, design correlations for cavitational intensity (in terms of collapse pressure)/cavitational yield and different successful chemical synthesis applications clearly illustrating the utility of these types of reactors. The theoretical discussion based on the modeling of the bubble dynamics equations aims at understanding the design information related to the dependency of the cavitational intensity on the operating parameters and recommendations have been made for the choice of the optimized conditions of operating parameters. The design information based on the theoretical analysis has also been supported with some experimental illustrations concentrating on the chemical synthesis applications. Assessment of the hydrodynamic cavitation reactors and comparison with the sonochemical reactors has been done by citing the different industrially important reactions (oxidation of toluene, o-xylene, m-xylene, p-xylene, mesitylene, o-nitrotoluene, p-nitrotoluene, m-nitrotoluene, o-chlorotoluene and p-chlorotoulene, and trans-esterification reaction i.e., synthesis of bio-diesel). Some recommendations have also been made for the future work to be carried out as well as the choice of the operating conditions for realizing the dream of industrial scale applications of the cavitational reactors.

Synthesis of AuPd alloyed nanoparticles via room-temperature electron reduction with argon glow discharge as electron source.

PubMed

Yang, Manman; Wang, Zongyuan; Wang, Wei; Liu, Chang-Jun

2014-01-01

Argon glow discharge has been employed as a cheap, environmentally friendly, and convenient electron source for simultaneous reduction of HAuCl4 and PdCl2 on the anodic aluminum oxide (AAO) substrate. The thermal imaging confirms that the synthesis is operated at room temperature. The reduction is conducted with a short time (30 min) under the pressure of approximately 100 Pa. This room-temperature electron reduction operates in a dry way and requires neither hydrogen nor extra heating nor chemical reducing agent. The analyses using X-ray photoelectron spectroscopy (XPS) confirm all the metallic ions have been reduced. The characterization with X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HRTEM) shows that AuPd alloyed nanoparticles are formed. There also exist some highly dispersed Au and Pd monometallic particles that cannot be detected by XRD and transmission electron microscopy (TEM) because of their small particle sizes. The observed AuPd alloyed nanoparticles are spherical with an average size of 14 nm. No core-shell structure can be observed. The room-temperature electron reduction can be operated in a larger scale. It is an easy way for the synthesis of AuPd alloyed nanoparticles.

How Design of Places Promotes or Inhibits Mobility of Older Adults: Realist Synthesis of 20 Years of Research

PubMed Central

Yen, Irene H.; Flood, Johnna Fandel; Thompson, Hannah; Anderson, Lynda A.; Wong, Geoff

2015-01-01

Objective The objective of this study was to determine the environmental features that best support aging in place. Method We conducted a realist synthesis, a theory-driven interpretive method of evidence synthesis, of 120+ articles (published 1991–2011) that attempts to explain how place may influence older adults’ decisions about mobility (e.g., physical activity). We developed an initial program theory, reviewed the literature, identified outcomes, analyzed and synthesized patterns, and created a final program theory. Results Safety was a central mechanism, serving as one of the bridges between environmental components (e.g., connectivity, aesthetics, retail and services) and decisions about mobility. Population density, sidewalk presence, and park proximity did not emerge as key factors. Discussion Safety considerations are one of the most prominent influences of older adults’ decisions about mobility. Street connectivity, pedestrian access and transit, and retail and services were also important. These factors are amenable to change and can help promote mobility for older adults. PMID:24788714

OPTICON: Pro-Matlab software for large order controlled structure design

NASA Technical Reports Server (NTRS)

Peterson, Lee D.

1989-01-01

A software package for large order controlled structure design is described and demonstrated. The primary program, called OPTICAN, uses both Pro-Matlab M-file routines and selected compiled FORTRAN routines linked into the Pro-Matlab structure. The program accepts structural model information in the form of state-space matrices and performs three basic design functions on the model: (1) open loop analyses; (2) closed loop reduced order controller synthesis; and (3) closed loop stability and performance assessment. The current controller synthesis methods which were implemented in this software are based on the Generalized Linear Quadratic Gaussian theory of Bernstein. In particular, a reduced order Optimal Projection synthesis algorithm based on a homotopy solution method was successfully applied to an experimental truss structure using a 58-state dynamic model. These results are presented and discussed. Current plans to expand the practical size of the design model to several hundred states and the intention to interface Pro-Matlab to a supercomputing environment are discussed.

Arctic Freshwater Synthesis: Summary of key emerging issues

NASA Astrophysics Data System (ADS)

Prowse, T.; Bring, A.; Mârd, J.; Carmack, E.; Holland, M.; Instanes, A.; Vihma, T.; Wrona, F. J.

2015-10-01

In response to a joint request from the World Climate Research Program's Climate and Cryosphere Project, the International Arctic Science Committee, and the Arctic Council's Arctic Monitoring and Assessment Program an updated scientific assessment has been conducted of the Arctic Freshwater System (AFS), entitled the Arctic Freshwater Synthesis (AFSΣ). The major reason behind the joint request was an increasing concern that changes to the AFS have produced, and could produce even greater, changes to biogeophysical and socioeconomic systems of special importance to northern residents and also produce extra-Arctic climatic effects that will have global consequences. The AFSΣ was structured around six key thematic areas: atmosphere, oceans, terrestrial hydrology, terrestrial ecology, resources, and modeling, the review of each coauthored by an international group of scientists and published as separate manuscripts in this special issue of Journal of Geophysical Research-Biogeosciences. This AFSΣ summary manuscript reviews key issues that emerged during the conduct of the synthesis, especially those that are cross-thematic in nature, and identifies future research required to address such issues.

Computer Aided Program Synthesis.

DTIC Science & Technology

1980-01-01

Representations 18 .2 Refinements and Reductions 18.:2.3 Dependenc ies 20 3.3 The Programming Knowledge Base 21 3.4 Linguistic Knowledge 22 3.5...strategy selection knowledge, i.e. knowledge representing a context sensitive discrimination among alternate methods; and knowledge of logical...program, each supplying his expertise. The client describes his task to the consultant and supplies answers and explanations to the consultant’s

Effective Reading Programs for Middle and High Schools: A Best-Evidence Synthesis. Educator's Summary

ERIC Educational Resources Information Center

Center for Data-Driven Reform in Education (NJ3), 2008

2008-01-01

What reading programs have been proven to help middle and high school students to succeed? To find out, this review summarizes evidence on four types of programs designed to improve the reading achievement of students in grades 6-12: (1) Reading Curricula (Curr), such as "LANGUAGE!," "McDougal Littel," and other standard and alternative textbooks;…

OPTIMIZING SYNTHESIS GAS YIELD FROM THE CROSS ...

EPA Pesticide Factsheets

Symposium Paper Biomass can be gasified to yield synthesis gas, tars, and ash. The process is governed by a number of parameters such as the temperature of the gasifying medium (in this case), and the moisture content of the feedstock. Synthesis gas from gasifying wood pellets was collected and analyzed as a function of inlet air temperature and feedstock moisture content. The air was introduced at temperatures ranging from 630 to 730 °C and the moisture content of the feedstock ranged from 8 to 20%. The data collected was used to establish the relationship between the outcome of gasification and these two parameters, and then to determine optimal operating parameters for maximizing the fuel value (maximizing the concentrations of flammable gases in the synthesis gas) while minimizing the production of gasification tars.

Synthesis, Transfer, and Characterization of Nanoscale 2-Dimensional Materials

DTIC Science & Technology

2015-09-01

deposition systems, leading to reduced operating costs. Transfer has been achieved using polymer-assisted methods , and material quality has been...Introduction and Background 1 2. Materials and Methods 1 3. Results and Discussion 2 3.1 Copper Foil Preparation 2 3.2 Graphene Synthesis and...magnification. a) 10 K, b) 18 K, c) 20 K, and d) 40 K. The red arrows indicate wrinkles in the film

Titanium(IV) isopropoxide mediated synthesis of pyrimidin-4-ones.

PubMed

Ramanjulu, Joshi M; Demartino, Michael P; Lan, Yunfeng; Marquis, Robert

2010-05-21

A novel, one-step method for the synthesis of tri- and tetrasubstituted pyrimidin-4-ones is reported. This method involves a titanium(IV)-mediated cyclization involving two sequential condensations of primary and beta-ketoamides. The reaction is operationally facile, readily scalable, and offers rapid entry into differentially substituted pyrimidin-4-one scaffolds. The high functional group compatibility allows for substantial diversification in the products generated from this transformation.

Sonochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles using nanocrystalline MgAl2O4 as an effective catalyst☆

PubMed Central

Safari, Javad; Gandomi-Ravandi, Soheila; Akbari, Zahra

2012-01-01

An efficient four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles is described by one-step condensation of an aldehyde, benzil, ammonium acetate and primary aromatic amine with nanocrystalline magnesium aluminate in ethanol under ultrasonic irradiation. High yields, short reaction times, mild conditions, simplicity of operation and easy work-up are some advantages of this protocol. PMID:25685459

Vasopressin synthesis by the magnocellular neurons is different in the supraoptic nucleus and in the paraventricular nucleus in human and experimental septic shock.

PubMed

Sonneville, Romain; Guidoux, Céline; Barrett, Lucinda; Viltart, Odile; Mattot, Virginie; Polito, Andrea; Siami, Shidasp; de la Grandmaison, Geoffroy Lorin; Blanchard, Anne; Singer, Mervyn; Annane, Djillali; Gray, Françoise; Brouland, Jean-Philippe; Sharshar, Tarek

2010-05-01

Impaired arginine vasopressin (AVP) synthesis and release by the neurohypophyseal system, which includes the neurohypophysis and magnocellular neurons of the paraventricular and supraoptic nuclei, have been postulated in septic shock, but changes in this system have never been assessed in human septic shock, and only partially experimentally. We investigated AVP synthesis and release by the neurohypophyseal system in 9 patients who died from septic shock and 10 controls, and in 20 rats with fecal peritonitis-induced sepsis and 8 sham-operation controls. Ten rats died spontaneously from septic shock, and the others were sacrificed. In patients with septic shock, as in rats that died spontaneously following sepsis induction, AVP immunohistochemical expression was decreased in the neurohypophysis and supraoptic magnocellular neurons, whereas it was increased in the paraventricular magnocellular neurons. No significant change was observed in AVP messenger RiboNucleic Acid (mRNA) expression assessed by in situ hybridization in either paraventricular or supraoptic magnocellular cells. This study shows that both in human and experimental septic shock, AVP posttranscriptional synthesis and transport are differently modified in the magnocellular neurons of the supraoptic and paraventricular nuclei. This may account for the inappropriate AVP release in septic shock and suggests that distinct pathogenic mechanisms operate in these nuclei.

Synthesis of active controls for flutter suppression on a flight research wing

NASA Technical Reports Server (NTRS)

Abel, I.; Perry, B., III; Murrow, H. N.

1977-01-01

This paper describes some activities associated with the preliminary design of an active control system for flutter suppression capable of demonstrating a 20% increase in flutter velocity. Results from two control system synthesis techniques are given. One technique uses classical control theory, and the other uses an 'aerodynamic energy method' where control surface rates or displacements are minimized. Analytical methods used to synthesize the control systems and evaluate their performance are described. Some aspects of a program for flight testing the active control system are also given. This program, called DAST (Drones for Aerodynamics and Structural Testing), employs modified drone-type vehicles for flight assessments and validation testing.

Formative evaluation of an Inspection Certificate Program (ICP) pilot in Toronto.

PubMed

Dwyer, J J; Komorowski, C; Ruf, F

1999-01-01

The inspection certificate program consists of food establishments voluntarily posting a certificate to inform patrons that inspection reports can be accessed from operators or the public health department. A three-month pilot program was evaluated for program improvement purposes. Only 65% of the selected operators were willing to participate, which suggests a challenge to fully implementing the program. Thirty-nine randomly selected restaurant operators participated. Most operators posted the certificate at the front entrance, and patrons indicated that reports were clear. Operators were supportive of the program. Some operators reported that the program was good for business and offered suggestions to improve it. A total of 583 requests for reports were made which suggests that the program empowered patrons to request reports, mostly from operators. Most patron evaluation forms came from a few operators that had no deficiencies, which limits generalizability.

Motivation of employers to encourage their employees to use safety belts (phase 2).

DOT National Transportation Integrated Search

1983-08-01

An employer manual is developed which offers guidelines for the elements of a successful safety bell program. The guidelines are based upon the model developed as a result of site visits to successful programs and synthesis of expert opinion. A needs...

Mindfulness in Academia: Considerations for Administrative Preparation

ERIC Educational Resources Information Center

Wells, Caryn M.

2013-01-01

This conceptual paper presents a synthesis of information about the workload stress of educational administrators. Currently, there are few programs designed to assist educational leaders to deal with stress (Hawk & Martin, 2011). Stress reduction programs may include mindfulness, a widely used practice of meditation. Mindfulness is used in…

An Overview of Starfish: A Table-Centric Tool for Interactive Synthesis

NASA Technical Reports Server (NTRS)

Tsow, Alex

2008-01-01

Engineering is an interactive process that requires intelligent interaction at many levels. My thesis [1] advances an engineering discipline for high-level synthesis and architectural decomposition that integrates perspicuous representation, designer interaction, and mathematical rigor. Starfish, the software prototype for the design method, implements a table-centric transformation system for reorganizing control-dominated system expressions into high-level architectures. Based on the digital design derivation (DDD) system a designer-guided synthesis technique that applies correctness preserving transformations to synchronous data flow specifications expressed as co- recursive stream equations Starfish enhances user interaction and extends the reachable design space by incorporating four innovations: behavior tables, serialization tables, data refinement, and operator retiming. Behavior tables express systems of co-recursive stream equations as a table of guarded signal updates. Developers and users of the DDD system used manually constructed behavior tables to help them decide which transformations to apply and how to specify them. These design exercises produced several formally constructed hardware implementations: the FM9001 microprocessor, an SECD machine for evaluating LISP, and the SchemEngine, garbage collected machine for interpreting a byte-code representation of compiled Scheme programs. Bose and Tuna, two of DDD s developers, have subsequently commercialized the design derivation methodology at Derivation Systems, Inc. (DSI). DSI has formally derived and validated PCI bus interfaces and a Java byte-code processor; they further executed a contract to prototype SPIDER-NASA's ultra-reliable communications bus. To date, most derivations from DDD and DRS have targeted hardware due to its synchronous design paradigm. However, Starfish expressions are independent of the synchronization mechanism; there is no commitment to hardware or globally broadcast clocks. Though software back-ends for design derivation are limited to the DDD stream-interpreter, targeting synchronous or real-time software is not substantively different from targeting hardware.

Time-frequency filtering and synthesis from convex projections

NASA Astrophysics Data System (ADS)

White, Langford B.

1990-11-01

This paper describes the application of the theory of projections onto convex sets to time-frequency filtering and synthesis problems. We show that the class of Wigner-Ville Distributions (WVD) of L2 signals form the boundary of a closed convex subset of L2(R2). This result is obtained by considering the convex set of states on the Heisenberg group of which the ambiguity functions form the extreme points. The form of the projection onto the set of WVDs is deduced. Various linear and non-linear filtering operations are incorporated by formulation as convex projections. An example algorithm for simultaneous time-frequency filtering and synthesis is suggested.

A versatile and convenient protocol for the stereocontrolled synthesis of olefinic insect pheromones.

PubMed

Vasil'ev, A A; Vlasyuk, A L; Gamalevich, G D; Serebryakov, E P

1996-03-01

A combination of the Horner-Emmons synthesis of alkyl 2,4-dienoates with their hydrogenation over complex L.Cr(CO)3 catalysts (L = 3CO or arene) provides a versatile, stereocontrolled and operationally simple approach to the (Z)-disubstituted, (Z)-trisubstituted, (E)-trisubstituted alkenes and skipped (Z,Z)-disubstituted diolefins with a homoallylic type of functionally. This protocol, sometimes supplemented by an enzymatic hydrolysis, was successfully applied to the synthesis of configurationally pure (gp > or = 98%) pheromones of the furniture carpet beetle, dry bean beetle, rusty grain beetle, square-necked grain beetle and a trail-following pheromone mimic for subterranean termites.

Thermomyces lanuginosus lipase-catalyzed synthesis of natural flavor esters in a continuous flow microreactor.

PubMed

Gumel, Ahmad Mohammed; Annuar, M S M

2016-06-01

Enzymatic catalysis is considered to be among the most environmental friendly processes for the synthesis of fine chemicals. In this study, lipase from Thermomyces lanuginosus (Lecitase Ultra™) was used to catalyze the synthesis of flavor esters, i.e., methyl butanoate and methyl benzoate by esterification of the acids with methanol in a microfluidic system. Maximum reaction rates of 195 and 115 mM min -1 corresponding to catalytic efficiencies (k cat /K M ) of 0.30 and 0.24 min -1  mM -1 as well as yield conversion of 54 and 41 % were observed in methyl butanoate and methyl benzoate synthesis, respectively. Catalytic turnover (k cat ) was higher for methyl butanoate synthesis. Rate of synthesis and yield decreased with increasing flow rates. For both esters, increase in microfluidic flow rate resulted in increased advective transport over molecular diffusion and reaction rate, thus lower conversion. In microfluidic synthesis using T. lanuginosus lipase, the following reaction conditions were 40 °C, flow rate 0.1 mL min -1 , and 123 U g -1 enzyme loading found to be the optimum operating limits. The work demonstrated the application of enzyme(s) in a microreactor system for the synthesis of industrially important esters.

25 CFR 39.137 - May schools operate a language development program without a specific appropriation from Congress?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false May schools operate a language development program... Formula Language Development Programs § 39.137 May schools operate a language development program without a specific appropriation from Congress? Yes, a school may operate a language development program...

Regular Mechanical Transformation of Rotations Into Translations: Part 2. Kinematic Synthesis of the Elements of High Kinematic Joints, Realizing the Process of Motions Transformation

NASA Astrophysics Data System (ADS)

Abadjieva, Emilia; Abadjiev, Valentin

2017-09-01

This work is developed on the basis of the illustrated main parts of the kinematic theory (theory of gearing) of the spatial rack drives in Part 1 of this study. The applied theoretical approach to their synthesis, based on the T. Olivier's second principle is defined. A study of the geometric nature of the surface of action (mesh region, respectively) of these class transmissions is shown. Research software programs for synthesis and visualization of these transmissions and their specific elements are elaborated, on the basis of the given algorithms to the synthesis of the elements of high kinematic joints (active tooth surfaces), with which the movable links of the studied gear systems are equipped.

A 3D Human-Machine Integrated Design and Analysis Framework for Squat Exercises with a Smith Machine.

PubMed

Lee, Haerin; Jung, Moonki; Lee, Ki-Kwang; Lee, Sang Hun

2017-02-06

In this paper, we propose a three-dimensional design and evaluation framework and process based on a probabilistic-based motion synthesis algorithm and biomechanical analysis system for the design of the Smith machine and squat training programs. Moreover, we implemented a prototype system to validate the proposed framework. The framework consists of an integrated human-machine-environment model as well as a squat motion synthesis system and biomechanical analysis system. In the design and evaluation process, we created an integrated model in which interactions between a human body and machine or the ground are modeled as joints with constraints at contact points. Next, we generated Smith squat motion using the motion synthesis program based on a Gaussian process regression algorithm with a set of given values for independent variables. Then, using the biomechanical analysis system, we simulated joint moments and muscle activities from the input of the integrated model and squat motion. We validated the model and algorithm through physical experiments measuring the electromyography (EMG) signals, ground forces, and squat motions as well as through a biomechanical simulation of muscle forces. The proposed approach enables the incorporation of biomechanics in the design process and reduces the need for physical experiments and prototypes in the development of training programs and new Smith machines.

Visual gene developer: a fully programmable bioinformatics software for synthetic gene optimization.

PubMed

Jung, Sang-Kyu; McDonald, Karen

2011-08-16

Direct gene synthesis is becoming more popular owing to decreases in gene synthesis pricing. Compared with using natural genes, gene synthesis provides a good opportunity to optimize gene sequence for specific applications. In order to facilitate gene optimization, we have developed a stand-alone software called Visual Gene Developer. The software not only provides general functions for gene analysis and optimization along with an interactive user-friendly interface, but also includes unique features such as programming capability, dedicated mRNA secondary structure prediction, artificial neural network modeling, network & multi-threaded computing, and user-accessible programming modules. The software allows a user to analyze and optimize a sequence using main menu functions or specialized module windows. Alternatively, gene optimization can be initiated by designing a gene construct and configuring an optimization strategy. A user can choose several predefined or user-defined algorithms to design a complicated strategy. The software provides expandable functionality as platform software supporting module development using popular script languages such as VBScript and JScript in the software programming environment. Visual Gene Developer is useful for both researchers who want to quickly analyze and optimize genes, and those who are interested in developing and testing new algorithms in bioinformatics. The software is available for free download at http://www.visualgenedeveloper.net.

Easily extensible unix software for spectral analysis, display, modification, and synthesis of musical sounds

NASA Astrophysics Data System (ADS)

Beauchamp, James W.

2002-11-01

Software has been developed which enables users to perform time-varying spectral analysis of individual musical tones or successions of them and to perform further processing of the data. The package, called sndan, is freely available in source code, uses EPS graphics for display, and is written in ansi c for ease of code modification and extension. Two analyzers, a fixed-filter-bank phase vocoder (''pvan'') and a frequency-tracking analyzer (''mqan'') constitute the analysis front end of the package. While pvan's output consists of continuous amplitudes and frequencies of harmonics, mqan produces disjoint ''tracks.'' However, another program extracts a fundamental frequency and separates harmonics from the tracks, resulting in a continuous harmonic output. ''monan'' is a program used to display harmonic data in a variety of formats, perform various spectral modifications, and perform additive resynthesis of the harmonic partials, including possible pitch-shifting and time-scaling. Sounds can also be synthesized according to a musical score using a companion synthesis language, Music 4C. Several other programs in the sndan suite can be used for specialized tasks, such as signal display and editing. Applications of the software include producing specialized sounds for music compositions or psychoacoustic experiments or as a basis for developing new synthesis algorithms.

A 3D Human-Machine Integrated Design and Analysis Framework for Squat Exercises with a Smith Machine

PubMed Central

Lee, Haerin; Jung, Moonki; Lee, Ki-Kwang; Lee, Sang Hun

2017-01-01

In this paper, we propose a three-dimensional design and evaluation framework and process based on a probabilistic-based motion synthesis algorithm and biomechanical analysis system for the design of the Smith machine and squat training programs. Moreover, we implemented a prototype system to validate the proposed framework. The framework consists of an integrated human–machine–environment model as well as a squat motion synthesis system and biomechanical analysis system. In the design and evaluation process, we created an integrated model in which interactions between a human body and machine or the ground are modeled as joints with constraints at contact points. Next, we generated Smith squat motion using the motion synthesis program based on a Gaussian process regression algorithm with a set of given values for independent variables. Then, using the biomechanical analysis system, we simulated joint moments and muscle activities from the input of the integrated model and squat motion. We validated the model and algorithm through physical experiments measuring the electromyography (EMG) signals, ground forces, and squat motions as well as through a biomechanical simulation of muscle forces. The proposed approach enables the incorporation of biomechanics in the design process and reduces the need for physical experiments and prototypes in the development of training programs and new Smith machines. PMID:28178184

Visual gene developer: a fully programmable bioinformatics software for synthetic gene optimization

PubMed Central

2011-01-01

Background Direct gene synthesis is becoming more popular owing to decreases in gene synthesis pricing. Compared with using natural genes, gene synthesis provides a good opportunity to optimize gene sequence for specific applications. In order to facilitate gene optimization, we have developed a stand-alone software called Visual Gene Developer. Results The software not only provides general functions for gene analysis and optimization along with an interactive user-friendly interface, but also includes unique features such as programming capability, dedicated mRNA secondary structure prediction, artificial neural network modeling, network & multi-threaded computing, and user-accessible programming modules. The software allows a user to analyze and optimize a sequence using main menu functions or specialized module windows. Alternatively, gene optimization can be initiated by designing a gene construct and configuring an optimization strategy. A user can choose several predefined or user-defined algorithms to design a complicated strategy. The software provides expandable functionality as platform software supporting module development using popular script languages such as VBScript and JScript in the software programming environment. Conclusion Visual Gene Developer is useful for both researchers who want to quickly analyze and optimize genes, and those who are interested in developing and testing new algorithms in bioinformatics. The software is available for free download at http://www.visualgenedeveloper.net. PMID:21846353

Parallelizing quantum circuit synthesis

NASA Astrophysics Data System (ADS)

Di Matteo, Olivia; Mosca, Michele

2016-03-01

Quantum circuit synthesis is the process in which an arbitrary unitary operation is decomposed into a sequence of gates from a universal set, typically one which a quantum computer can implement both efficiently and fault-tolerantly. As physical implementations of quantum computers improve, the need is growing for tools that can effectively synthesize components of the circuits and algorithms they will run. Existing algorithms for exact, multi-qubit circuit synthesis scale exponentially in the number of qubits and circuit depth, leaving synthesis intractable for circuits on more than a handful of qubits. Even modest improvements in circuit synthesis procedures may lead to significant advances, pushing forward the boundaries of not only the size of solvable circuit synthesis problems, but also in what can be realized physically as a result of having more efficient circuits. We present a method for quantum circuit synthesis using deterministic walks. Also termed pseudorandom walks, these are walks in which once a starting point is chosen, its path is completely determined. We apply our method to construct a parallel framework for circuit synthesis, and implement one such version performing optimal T-count synthesis over the Clifford+T gate set. We use our software to present examples where parallelization offers a significant speedup on the runtime, as well as directly confirm that the 4-qubit 1-bit full adder has optimal T-count 7 and T-depth 3.

Using Realist Synthesis to Develop an Evidence Base from an Identified Data Set on Enablers and Barriers for Alcohol and Drug Program Implementation

ERIC Educational Resources Information Center

Hunter, Barbara; MacLean, Sarah; Berends, Lynda

2012-01-01

The purpose of this paper is to show how "realist synthesis" methodology (Pawson, 2002) was adapted to review a large sample of community based projects addressing alcohol and drug use problems. Our study drew on a highly varied sample of 127 projects receiving funding from a national non-government organisation in Australia between 2002…

Synthesis of New Organic Semiconducting Polymer Materials Having High Radiowave Absorption Rate

DTIC Science & Technology

2008-11-01

ISTC Project No. #1571P Synthesis of New Organic Semiconducting Polymer Materials Having High Radiowave Absorption Rate Final Project Technical...Technology Center ( ISTC ), Moscow. REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information...polymer materials having high radiowave absorption rate 5a. CONTRACT NUMBER ISTC Registration No: A-1571p 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

Research perspectives on the public and fire management: a synthesis of current social science on eight essential questions

Treesearch

Sarah M. McCaffrey; Christine S. Olsen

2012-01-01

As part of a Joint Fire Science Program project, a team of social scientists reviewed existing fire social science literature to develop a targeted synthesis of scientific knowledge on the following questions: 1. What is the public's understanding of fire's role in the ecosystem? 2. Who are trusted sources of information about fire? 3. What are the public...

Synthesis of Key Points from the OSEP Early Childhood Transition FAQ (SPP/APR Indicators C-8, B-11 and B-12)

ERIC Educational Resources Information Center

Diefendorf, M.; Henson, J.; Lucas, A.; Whaley, K.

2010-01-01

This document is a synthesis of the key points provided in the Office of Special Education Programs (OSEP) Early Childhood Transition FAQs: SPP/APR indicators C-8 and B-12 released on December 1, 2009. It was developed to assist states with the implementation of effective transition policies and practices. The following is included: (1) Transition…

LOGIC NETS, THEIR CHARACTERIZATION, RELIABILITY, AND EFFICIENT SYNTHESIS.

DTIC Science & Technology

The report consists of two parts. The first discusses a problem in the dual-support approach to network synthesis using threshold gates, gives new...asymptotic results on the number of threshold gates and the size of threshold gate networks, and summarizes the work in threshold logic supported by...this contract, including programs to facilitate experimentation in the design of networks of threshold gates. The second summarizes CDL1 - Computer

Teacher Induction: A New Beginning. Papers from the National Commission on the Induction Process.

ERIC Educational Resources Information Center

Brooks, Douglas M., Ed.

The following papers are included in this monograph that provides a synthesis on beginning teacher induction: (1) "Teacher Induction" (Leslie Huling-Austin); (2) "Local Induction Programs" (Ralph Kester and Mary Marockie); (3) "Statewide Teacher Induction Programs" (Parmalee Hawk and Shirley Robards); (4) "The…

Chemistry. Focus on Excellence, Volume 3, Number 2.

ERIC Educational Resources Information Center

Penick, John E., Ed.; Krajcik, Joseph, Ed.

Eight examples of innovative and outstanding chemistry programs are described. These programs were selected using state criteria and at least four independent reviewers. While Project Synthesis offered a desired state, these examples of excellence provided views of what is already a reality. Included are the goals of an exemplary science program…

Computer Series, 65. Bits and Pieces, 26.

ERIC Educational Resources Information Center

Moore, John W., Ed.

1985-01-01

Describes: (l) a microcomputer-based system for filing test questions and assembling examinations; (2) microcomputer use in practical and simulated experiments of gamma rays scattering by outer shell electrons; (3) an interactive, screen-oriented, general linear regression program; and (4) graphics drill and game programs for benzene synthesis.…

AN INTEGRATED SYNTHESIS OF KEY AND POLICY RELEVANT FINDINGS FROM EPA'S SUPERSITES PROGRAM AND RELATED STUDIES

EPA Science Inventory

This presentation provides an overview and initial insights into the findings based on results from EPA's PM Supersites Program and related studies. Many key atmospheric sciences findings have been identified through the research conducted during the last five years as part of t...

Family Support in Children's Mental Health: A Review and Synthesis

ERIC Educational Resources Information Center

Hoagwood, Kimberly E.; Cavaleri, Mary A.; Olin, S. Serene; Burns, Barbara J.; Slaton, Elaine; Gruttadaro, Darcy; Hughes, Ruth

2010-01-01

A comprehensive review of structured family support programs in children's mental health was conducted in collaboration with leadership from key national family organizations. The goals were to identify typologies of family support services for which evaluation data existed and identify research gaps. Over 200 programs were examined; 50 met…

AN EVALUATION OF HEURISTICS FOR THRESHOLD-FUNCTION TEST-SYNTHESIS,

DTIC Science & Technology

Linear programming offers the most attractive procedure for testing and obtaining optimal threshold gate realizations for functions generated in...The design of the experiments may be of general interest to students of automatic problem solving; the results should be of interest in threshold logic and linear programming. (Author)

Metric-wave and decimetric-wave aperture synthesis systems (review)

NASA Astrophysics Data System (ADS)

Ilyasov, Y. P.

1984-09-01

Aperture synthesis systems using metric or decimetric waves are adequate and promising for astrophysical study of extragalactic radioemission sources, operation with metric waves being characterized by destabilizing effects of the ionosphere and thus requiring special methods of data processing. Methods of closure phase and closure amplitude were proposed and then successfully implemented in very-large-baseline radiotelescope and multi-element interferometers, respectively. Several radiotelescopes were developed which operate in the supersynthesis mode, with rotation of the Earth used for filling the space-frequency plane. Further achievements include the Swarup system (Uti/INDIA) with phase-stable interferometer, the Jodrell Bank system (Manchester/UK), the Palmer Merlin multielement system (UK) with CLEAN procedure and CORTEL telescope correction algorithm, the VLA system (USA), and the international giant equatorial radiotelescope.

Hypersonic vehicle control law development using H(infinity) and micron-synthesis

NASA Technical Reports Server (NTRS)

Gregory, Irene M.; Mcminn, John D.; Shaughnessy, John D.; Chowdhry, Rajiv S.

1993-01-01

Hypersonic vehicle control law development using H(infinity) and mu-synthesis is discussed. Airbreathing SSTO vehicles has a mutli-faceted mission that includes orbital operations, as well as re-entry and descent culminating in horizontal landing. However, the most challenging part of the operations is the ascent to orbit. The airbreathing propulsion requires lengthy atmospheric flight that may last as long as 30 minutes and take the vehicle half way around the globe. The vehicles's ascent is characterized by tight payload to orbit margins which translate into minimum fuel orbit as the performance criteria. Issues discussed include: SSTO airbreathing vehicle issues; control system performance requirements; robust control law framework; H(infinity) controller frequency analysis; and mu controller frequency analysis.

An OKQPSK modem incorporating numerically controlled carrier synthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oetken, R.E.

1988-04-04

The feasibility of incorporating numerically controlled oscillators (NCO) in communication related applications is evaluated. NCO generation of sinusoids may prove useful in systems requiring precise frequency control, tuning linearity, and orthogonality versus frequency. An OKQPSK modem operating at a data rate of 200 kb/s was fabricated. The modem operates in a back to back hardwired channel and thus does not incorporate carrier or symbol timing recovery. Spectra of the NCO generated sinusoids are presented along with waveforms from the modulation and demodulation process. Generation of sinusoids in the digital domain is a viable alternative to analog oscillators. Implementation of anmore » NCO should be considered when frequency allocation, tuning bandwidth, or frequency hopped transmission requires precise frequency synthesis. 24 figs.« less

Human operator identification model and related computer programs

NASA Technical Reports Server (NTRS)

Kessler, K. M.; Mohr, J. N.

1978-01-01

Four computer programs which provide computational assistance in the analysis of man/machine systems are reported. The programs are: (1) Modified Transfer Function Program (TF); (2) Time Varying Response Program (TVSR); (3) Optimal Simulation Program (TVOPT); and (4) Linear Identification Program (SCIDNT). The TV program converts the time domain state variable system representative to frequency domain transfer function system representation. The TVSR program computes time histories of the input/output responses of the human operator model. The TVOPT program is an optimal simulation program and is similar to TVSR in that it produces time histories of system states associated with an operator in the loop system. The differences between the two programs are presented. The SCIDNT program is an open loop identification code which operates on the simulated data from TVOPT (or TVSR) or real operator data from motion simulators.

Fuels planning: science synthesis and integration; social issues fact sheet 01: Developing personal responsibility for fuels reduction: Building a successful program to engage property owners

Treesearch

Rocky Mountain Research Station USDA Forest Service

2004-01-01

In the course of work as a land manager, you will no doubt be involved in developing programs to achieve various objectives, including the improvement of fuels management on private lands. This fact sheet describes six steps that will help you plan and conduct a successful program.

75 FR 48329 - Tribal Drinking Water Operator Certification Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-10

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9186-8] Tribal Drinking Water Operator Certification Program... details of EPA's voluntary Tribal Drinking Water Operator Certification Program, effective October 1, 2010. The program enables qualified drinking water operators at public water systems in Indian country to be...

Synthetic biology: advancing the design of diverse genetic systems

PubMed Central

Wang, Yen-Hsiang; Wei, Kathy Y.; Smolke, Christina D.

2013-01-01

A main objective of synthetic biology is to make the process of designing genetically-encoded biological systems more systematic, predictable, robust, scalable, and efficient. The examples of genetic systems in the field vary widely in terms of operating hosts, compositional approaches, and network complexity, ranging from a simple genetic switch to search-and-destroy systems. While significant advances in synthesis capabilities support the potential for the implementation of pathway- and genome-scale programs, several design challenges currently restrict the scale of systems that can be reasonably designed and implemented. Synthetic biology offers much promise in developing systems to address challenges faced in manufacturing, the environment and sustainability, and health and medicine, but the realization of this potential is currently limited by the diversity of available parts and effective design frameworks. As researchers make progress in bridging this design gap, advances in the field hint at ever more diverse applications for biological systems. PMID:23413816

Future orientation: a construct with implications for adolescent health and wellbeing.

PubMed

Johnson, Sarah R Lindstrom; Blum, Robert W; Cheng, Tina L

2014-01-01

Multidisciplinary research has supported a relationship between adolescent future orientation (the ability to set future goals and plans) and positive adolescent health and development outcomes. Many preventive strategies - for example, contracepting, exercising - are based on taking actions in the present to avoid unwanted or negative future consequences. However, research has been hampered by unclear and often divergent conceptualizations of the future orientation construct. The present paper aims to integrate previous conceptual and operational definitions into a conceptual framework that can inform programs and services for youth and efforts to evaluate future orientation as a target for intervention. Recommendations focus on furthering the study of the construct through measurement synthesis as well as studies of the normative development of future orientation. Also suggested is the need to pair environmental intervention strategies with individual level efforts to improve future orientation in order to maximize benefits.

Future Orientation: A Construct with Implications for Adolescent Health and Wellbeing

PubMed Central

Lindstrom Johnson, Sarah; Blum, Robert W; Cheng, Tina L.

2016-01-01

Multi-disciplinary research has supported a relationship between adolescent future orientation (the ability to set future goals and plans) and positive adolescent health and development outcomes. Many preventive strategies—for example contracepting, exercising—are based on taking actions in the present to avoid unwanted or negative future consequences. However, research has been hampered by unclear and often divergent conceptualizations of the future orientation construct. The present paper aims to integrate previous conceptual and operational definitions into a conceptual framework that can inform programs and services for youth and efforts to evaluate future orientation as a target for intervention. Recommendations focus on furthering the study of the construct through measurement synthesis as well as studies of the normative development of future orientation. Also suggested is the need to pair environmental intervention strategies with individual level efforts to improve future orientation in order to maximize benefits. PMID:24523304

Advanced composite rudders for DC-10 aircraft: Design, manufacturing, and ground tests

NASA Technical Reports Server (NTRS)

Lehman, G. M.; Purdy, D. M.; Cominsky, A.; Hawley, A. V.; Amason, M. P.; Kung, J. T.; Palmer, R. J.; Purves, N. B.; Marra, P. J.; Hancock, G. R.

1976-01-01

Design synthesis, tooling and process development, manufacturing, and ground testing of a graphite epoxy rudder for the DC-10 commercial transport are discussed. The composite structure was fabricated using a unique processing method in which the thermal expansion characteristics of rubber tooling mandrels were used to generate curing pressures during an oven cure cycle. The ground test program resulted in certification of the rudder for passenger-carrying flights. Results of the structural and environmental tests are interpreted and detailed development of the rubber tooling and manufacturing process is described. Processing, tooling, and manufacturing problems encountered during fabrication of four development rudders and ten flight-service rudders are discussed and the results of corrective actions are described. Non-recurring and recurring manufacturing labor man-hours are tabulated at the detailed operation level. A weight reduction of 13.58 kg (33 percent) was attained in the composite rudder.

Six-flow operations for catalyst development in Fischer-Tropsch synthesis: Bridging the gap between high-throughput experimentation and extensive product evaluation

NASA Astrophysics Data System (ADS)

Sartipi, Sina; Jansma, Harrie; Bosma, Duco; Boshuizen, Bart; Makkee, Michiel; Gascon, Jorge; Kapteijn, Freek

2013-12-01

Design and operation of a "six-flow fixed-bed microreactor" setup for Fischer-Tropsch synthesis (FTS) is described. The unit consists of feed and mixing, flow division, reaction, separation, and analysis sections. The reactor system is made of five heating blocks with individual temperature controllers, assuring an identical isothermal zone of at least 10 cm along six fixed-bed microreactor inserts (4 mm inner diameter). Such a lab-scale setup allows running six experiments in parallel, under equal feed composition, reaction temperature, and conditions of separation and analysis equipment. It permits separate collection of wax and liquid samples (from each flow line), allowing operation with high productivities of C5+ hydrocarbons. The latter is crucial for a complete understanding of FTS product compositions and will represent an advantage over high-throughput setups with more than ten flows where such instrumental considerations lead to elevated equipment volume, cost, and operation complexity. The identical performance (of the six flows) under similar reaction conditions was assured by testing a same catalyst batch, loaded in all microreactors.

Efficient and Convenient Synthesis of 1,8-Dioxodecahydroacridine Derivatives Using Cu-Doped ZnO Nanocrystalline Powder as a Catalyst under Solvent-Free Conditions

PubMed Central

Alinezhad, Heshmatollah; Mohseni Tavakkoli, Sahar

2013-01-01

A simple and convenient one-step method for synthesis of acridines and their derivatives from condensation of aromatic aldehydes, cyclic diketones, and aryl amines using Cu-doped ZnO nanocrystalline powder as a catalyst is reported. The present protocol provides several advantages such as good yields, short reaction time, easy workup, and simplicity in operation. PMID:24294130

Diversity-oriented synthesis of dihydrobenzoxazepinones by coupling the Ugi multicomponent reaction with a Mitsunobu cyclization

PubMed Central

Moni, Lisa; Banfi, Luca; Basso, Andrea; Brambilla, Alice

2014-01-01

Summary An operationally simple protocol for the synthesis of 2,3-dihydrobenzo[f][1,4]oxazepin-3-ones, based on an Ugi reaction of an ortho-(benzyloxy)benzylamine, glycolic acid, an isocyanide and an aldehyde, followed by an intramolecular Mitsunobu substitution was developed. The required ortho-(benzyloxy)benzylamines have been in situ generated from the corresponding azides, in turn prepared in high yields from salicylic derivatives. PMID:24605140

Synthesis of an air-working trilayer artificial muscle using a conductive cassava starch biofilm (manihot esculenta, cranz) and polypyrrole (PPy)

NASA Astrophysics Data System (ADS)

Núñez D, Y. E.; Arrieta A, Á. A.; Segura B, J. A.; Bertel H, S. D.

2016-02-01

In this study, a methodology for obtaining a conductive cassava starch biofilm doped with lithium perchlorate (LiClO4) is shown, as well as the electrochemical technique for the synthesis of polypyrrole films, which are used for developing the trilayer artificial muscle PPy/Biopolymer/PPy designed to operate in air. Furthermore, results from the trilayer movement using chronoamperometric techniques are shown.

Synthesis of Algorithm for Range Measurement Equipment to Track Maneuvering Aircraft Using Data on Its Dynamic and Kinematic Parameters

NASA Astrophysics Data System (ADS)

Pudovkin, A. P.; Panasyuk, Yu N.; Danilov, S. N.; Moskvitin, S. P.

2018-05-01

The problem of improving automated air traffic control systems is considered through the example of the operation algorithm synthesis for a range measurement channel to track the aircraft, using its kinematic and dynamic parameters. The choice of the state and observation models has been justified, the computer simulations have been performed and the results of the investigated algorithms have been obtained.

76 FR 12926 - Clean Air Act Proposed Interim Approval of Title V Operating Permits Program; Southern Ute Indian...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... Proposed Interim Approval of Title V Operating Permits Program; Southern Ute Indian Tribe AGENCY... Title V Operating Permits Program submitted by the Southern Ute Indian Tribe (Tribe). The Tribe's Title V Operating Permit Program (Title V Program) was submitted for the purpose of administering a tribal...

Site operator program final report for fiscal years 1992 through 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Francfort, J.E.; Bassett, R.R.; Birasco, S.

The Site Operator Program was an electric vehicle testing and evaluation program sponsored by US Department of Energy and managed at the Idaho National Engineering and Environmental Laboratory. The Program`s goals included the field evaluation of electric vehicles in real-world applications and environments; the support of electric vehicle technology advancement; the development of infrastructure elements necessary to support significant electric vehicle use; and increasing the awareness and acceptance of electric vehicles. This report covers Program activities from 1992 to 1996. The Site Operator Program ended in September 1996, when it was superseded by the Field Operations Program. Electric vehicle testingmore » included baseline performance testing, which was performed in conjunction with EV America. The baseline performance parameters included acceleration, braking, range, energy efficiency, and charging time. The Program collected fleet operations data on electric vehicles operated by the Program`s thirteen partners, comprising electric utilities, universities, and federal agencies. The Program`s partners had over 250 electric vehicles, from vehicle converters and original equipment manufacturers, in their operating fleets. Test results are available via the World Wide Web site at http://ev.inel.gov/sop.« less

Design, Synthesis and Mechanistic Evaluation of Iron-Based Catalysis for Synthesis Gas Conversion to Fuels and Chemicals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akio Ishikawa; Manuel Ojeda; Nan Yao

2007-03-31

This project extends previously discovered Fe-based catalysts to hydrogen-poor synthesis gas streams derived from coal and biomass sources. These catalysts have shown unprecedented Fischer-Tropsch synthesis rates and selectivities for synthesis gas derived from methane. During the first reporting period, we certified a microreactor, installed required analytical equipment, and reproduced synthetic protocols and catalytic results previously reported. During the second reporting period, we prepared several Fe-based compositions for Fischer-Tropsch Synthesis and tested the effects of product recycle under both subcritical and supercritical conditions. During the third and fourth reporting periods, we improved the catalysts preparation method, which led to Fe-based materialsmore » with the highest FTS reaction rates and selectivities so far reported, a finding that allowed their operation at lower temperatures and pressures with high selectivity to desired products (C{sub 5+}, olefins). During the fifth and sixth reporting period, we studied the effects of different promoters on catalytic performance, specifically how their sequence of addition dramatically influenced the performance of these materials in the Fischer-Tropsch synthesis. We also continued our studies of the kinetic behavior of these materials during the sixth reporting period. Specifically, the effects of H{sub 2}, CO, and CO{sub 2} on the rates and selectivities of Fischer-Tropsch Synthesis reactions led us to propose a new sequence of elementary steps on Fe and Co Fischer-Tropsch catalysts. Finally, we also started a study of the use of colloidal precipitation methods for the synthesis small Co clusters using recently developed methods to explore possible further improvements in FTS rates and selectivities. We found that colloidal synthesis makes possible the preparation of small cobalt particles, although large amount of cobalt silicate species, which are difficult to reduce, were formed. During this seventh reporting period, we have explored several methods to modify the silanol groups on SiO{sub 2} by using either a homogeneous deposition-precipitation method or surface titration of Si-OH on SiO{sub 2} with zirconium (IV) ethoxide to prevent the formation of unreducible and unreactive CoO{sub x} species during synthesis and FTS catalysis. We have synthesized monometallic Co/ZrO{sub 2}/SiO{sub 2} catalysts with different Co loadings (11-20 wt%) by incipient wetness impregnation methods and characterized the prepared Co supported catalysts by H{sub 2} temperature-programmed reduction (H{sub 2}-TPR) and H{sub 2}-chemisorption. We have measured the catalytic performance in FTS reactions and shown that although the hydroxyl groups on the SiO{sub 2} surface are difficult to be fully titrated by ZrO{sub 2}, modification of ZrO{sub 2} on SiO{sub 2} surface can improve the Co clusters dispersion and lead to a larger number of exposed Co surface atoms after reduction and during FTS reactions. During this seventh reporting period, we have also advanced our development of the reaction mechanism proposed in the previous reporting period. Specifically, we have shown that our novel proposal for the pathways involved in CO activation on Fe and Co catalysts is consistent with state-of-the-art theoretical calculations carried out in collaboration with Prof. Manos Mavrikakis (University of Wisconsin-Madison). Finally, we have also worked on the preparation of several manuscripts describing our findings about the preparation, activation and mechanism of the FTS with Fe-based catalysts and we have started redacting the final report for this project.« less

Improving cancer treatment with cyclotron produced radionuclides. Progress report, February 1987--September 1989

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larson, S.M.

This report is divided into six sections, each section dealing with a separate aspect of the program. The six sections are entitled (1) In Vivo Measurement of Amino Acid Transport and Protein Synthesis, (2) Angiogenesis in Human Gliomas: Correlations with Blood Flow and Transport of C-11 AIB, (3) Use of F-18 Fluoropyrimidines for Design and Evaluation of Regional and Systemic Chemotherapeutic Strategies in Human Adenocarcinomas of the Gastrointestinal Tract, (4) Enzymatic Synthesis of Metabolites Labeled with N-13 or C-11, (5) Synthesis of Amino Acids Labeled with C-11, and (6) Instrumentation: Cyclotron and Imaging Systems.

The synthesis of a tritium, carbon-14, and stable isotope-labeled cathepsin C inhibitors.

PubMed

Allen, Paul; Bragg, Ryan A; Caffrey, Moya; Ericsson, Cecilia; Hickey, Michael J; Kingston, Lee P; Elmore, Charles S

2017-02-01

As part of a medicinal chemistry program aimed at developing a highly potent and selective cathepsin C inhibitor, tritium, carbon-14, and stable isotope-labeled materials were required. The synthesis of tritium-labeled methanesulfonate 5 was achieved via catalytic tritiolysis of a chloro precursor, albeit at a low radiochemical purity of 67%. Tritium-labeled AZD5248 was prepared via a 3-stage synthesis, utilizing amide-directed hydrogen isotope exchange. Carbon-14 and stable isotope-labeled AZD5248 were successfully prepared through modifications of the medicinal chemistry synthetic route, enabling the use of available labeled intermediates. Copyright © 2016 John Wiley & Sons, Ltd.

Critical role of a double-layer configuration in solution-based unipolar resistive switching memories.

PubMed

Carlos, Emanuel; Kiazadeh, Asal; Deuermeier, Jonas; Branquinho, Rita; Martins, Rodrigo; Fortunato, Elvira

2018-08-24

Lately, resistive switching memories (ReRAM) have been attracting a lot of attention due to their possibilities of fast operation, lower power consumption and simple fabrication process and they can also be scaled to very small dimensions. However, most of these ReRAM are produced by physical methods and nowadays the industry demands more simplicity, typically associated with low cost manufacturing. As such, ReRAMs in this work are developed from a solution-based aluminum oxide (Al 2 O 3 ) using a simple combustion synthesis process. The device performance is optimized by two-stage deposition of the Al 2 O 3 film. The resistive switching properties of the bilayer devices are reproducible with a yield of 100%. The ReRAM devices show unipolar resistive switching behavior with good endurance and retention time up to 10 5 s at 85 °C. The devices can be programmed in a multi-level cell operation mode by application of different reset voltages. Temperature analysis of various resistance states reveals a filamentary nature based on the oxygen vacancies. The optimized film was stacked between ITO and indium zinc oxide, targeting a fully transparent device for applications on transparent system-on-panel technology.

ASIC implementation of recursive scaled discrete cosine transform algorithm

NASA Astrophysics Data System (ADS)

On, Bill N.; Narasimhan, Sam; Huang, Victor K.

1994-05-01

A program to implement the Recursive Scaled Discrete Cosine Transform (DCT) algorithm as proposed by H. S. Hou has been undertaken at the Institute of Microelectronics. Implementation of the design was done using top-down design methodology with VHDL (VHSIC Hardware Description Language) for chip modeling. When the VHDL simulation has been satisfactorily completed, the design is synthesized into gates using a synthesis tool. The architecture of the design consists of two processing units together with a memory module for data storage and transpose. Each processing unit is composed of four pipelined stages which allow the internal clock to run at one-eighth (1/8) the speed of the pixel clock. Each stage operates on eight pixels in parallel. As the data flows through each stage, there are various adders and multipliers to transform them into the desired coefficients. The Scaled IDCT was implemented in a similar fashion with the adders and multipliers rearranged to perform the inverse DCT algorithm. The chip has been verified using Field Programmable Gate Array devices. The design is operational. The combination of fewer multiplications required and pipelined architecture give Hou's Recursive Scaled DCT good potential of achieving high performance at a low cost in using Very Large Scale Integration implementation.

Relative Sensor with 4(pi) Coverage for Formation Flying Missions

NASA Technical Reports Server (NTRS)

Tien, Jeffrey Y.; Purcell, George H., Jr.; Sirinivasan, Jeffrey M.; Young, Lawrence E.

2004-01-01

The Terrestrial Planet Finder (TPF) pre-project, an element of NASA's Origins program, is currently developing two architectures for a mission to search for earth-like planets around nearby stars. One of the architectures being developed is the Formation Flying Interferometer (FFI). The FFI is envisioned to consist of up to seven spacecraft (as many as six 'collectors' with IR telescopes, and a 'combiner') flying in precise formation within f 1 cm of pre-determined trajectories for synchronized observations. The spacecraft-to-spacecraft separations are variable between 20 m and 100 m or more during observations to support various configurations of the interferometer in the planet-finding mode. The challenges involved with TPF autonomous operations, ranging from formation acquisition and formation maneuvering to high precision formation control during science observations, are unprecedented. In this paper we discuss the development of the formation acquisition sensor, which uses novel modulation and duplexing schemes to enable fast signal acquisition, multiple-spacecraft operation, and mitigation of inherent jamming conditions, while providing precise formation sensing and integrated radar capability. This approach performs delay synthesis and carrier cycle ambiguity resolution to improve range measurement, and uses differential carrier cycle ambiguity resolution to make precise bearing angle measurements without calibration maneuvers.

Relative Sensor with 4Pi Coverage for Formation Flying Missions

NASA Technical Reports Server (NTRS)

Tien, Jeffrey Y.; Purcell, George H., Jr.; Srinivasan, Jeffrey M.; Young, Lawrence E.

2004-01-01

The Terrestrial Planet Finder (TPF) pre-project, an element of NASA s Origins program, is currently developing two architectures for a mission to search for earth-like planets around nearby stars. One of the architectures being developed is the Formation Flying Interferometer (FFI). The FFI is envisioned to consist of up to seven spacecraft (as many as six "collectors" with IR telescopes, and a "combiner") flying in precise formation within +/-1 cm of pre-determined trajectories for synchronized observations. The spacecraft-to-spacecraft separations are variable between 20 m and 100 m or more during observations to support various configurations of the interferometer in the planet-finding mode. The challenges involved with TPF autonomous operations, ranging from formation acquisition and formation maneuvering to high precision formation control during science observations, are unprecedented. In this paper we discuss the development of the formation acquisition sensor, which uses novel modulation and duplexing schemes to enable fast signal acquisition, multiple-spacecraft operation, and mitigation of inherent jamming conditions, while providing precise formation sensing and integrated radar capability. This approach performs delay synthesis and carrier cycle ambiguity resolution to improve range measurement, and uses differential carrier cycle ambiguity resolution to make precise bearing angle measurements without calibration maneuvers.

An Intelligent Harmonic Synthesis Technique for Air-Gap Eccentricity Fault Diagnosis in Induction Motors

NASA Astrophysics Data System (ADS)

Li, De Z.; Wang, Wilson; Ismail, Fathy

2017-11-01

Induction motors (IMs) are commonly used in various industrial applications. To improve energy consumption efficiency, a reliable IM health condition monitoring system is very useful to detect IM fault at its earliest stage to prevent operation degradation, and malfunction of IMs. An intelligent harmonic synthesis technique is proposed in this work to conduct incipient air-gap eccentricity fault detection in IMs. The fault harmonic series are synthesized to enhance fault features. Fault related local spectra are processed to derive fault indicators for IM air-gap eccentricity diagnosis. The effectiveness of the proposed harmonic synthesis technique is examined experimentally by IMs with static air-gap eccentricity and dynamic air-gap eccentricity states under different load conditions. Test results show that the developed harmonic synthesis technique can extract fault features effectively for initial IM air-gap eccentricity fault detection.

Designing a multiroute synthesis scheme in combinatorial chemistry.

PubMed

Akavia, Adi; Senderowitz, Hanoch; Lerner, Alon; Shamir, Ron

2004-01-01

Solid-phase mix-and-split combinatorial synthesis is often used to produce large arrays of compounds to be tested during the various stages of the drug development process. This method can be represented by a synthesis graph in which nodes correspond to grow operations and arcs to beads transferred among the different reaction vessels. In this work, we address the problem of designing such a graph which maximizes the number of produced target compounds (namely, compounds out of an input library of desired molecules), given constraints on the number of beads used for library synthesis and on the number of reaction vessels available for concurrent grow steps. We present a heuristic based on a discrete search for solving this problem, test our solution on several data sets, explore its behavior, and show that it achieves good performance.

Improved synthesis of [(18)F]FLETT via a fully automated vacuum distillation method for [(18)F]2-fluoroethyl azide purification.

PubMed

Ackermann, Uwe; Plougastel, Lucie; Goh, Yit Wooi; Yeoh, Shinn Dee; Scott, Andrew M

2014-12-01

The synthesis of [(18)F]2-fluoroethyl azide and its subsequent click reaction with 5-ethynyl-2'-deoxyuridine (EDU) to form [(18)F]FLETT was performed using an iPhase FlexLab module. The implementation of a vacuum distillation method afforded [(18)F]2-fluoroethyl azide in 87±5.3% radiochemical yield. The use of Cu(CH3CN)4PF6 and TBTA as catalyst enabled us to fully automate the [(18)F]FLETT synthesis without the need for the operator to enter the radiation field. [(18)F]FLETT was produced in higher overall yield (41.3±6.5%) and shorter synthesis time (67min) than with our previously reported manual method (32.5±2.5% in 130min). Copyright © 2014 Elsevier Ltd. All rights reserved.

A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century.

PubMed

Godfrey, Alexander G; Masquelin, Thierry; Hemmerle, Horst

2013-09-01

This article describes our experiences in creating a fully integrated, globally accessible, automated chemical synthesis laboratory. The goal of the project was to establish a fully integrated automated synthesis solution that was initially focused on minimizing the burden of repetitive, routine, rules-based operations that characterize more established chemistry workflows. The architecture was crafted to allow for the expansion of synthetic capabilities while also providing for a flexible interface that permits the synthesis objective to be introduced and manipulated as needed under the judicious direction of a remote user in real-time. This innovative central synthesis suite is herein described along with some case studies to illustrate the impact such a system is having in expanding drug discovery capabilities. Copyright © 2013 Elsevier Ltd. All rights reserved.

What Is Lean Management in Health Care? Development of an Operational Definition for a Cochrane Systematic Review.

PubMed

Rotter, Thomas; Plishka, Christopher; Lawal, Adegboyega; Harrison, Liz; Sari, Nazmi; Goodridge, Donna; Flynn, Rachel; Chan, James; Fiander, Michelle; Poksinska, Bonnie; Willoughby, Keith; Kinsman, Leigh

2018-01-01

Industrial improvement approaches such as Lean management are increasingly being adopted in health care. Synthesis is necessary to ensure these approaches are evidence based and requires operationalization of concepts to ensure all relevant studies are included. This article outlines the process utilized to develop an operational definition of Lean in health care. The literature search, screening, data extraction, and data synthesis processes followed the recommendations outlined by the Cochrane Collaboration. Development of the operational definition utilized the methods prescribed by Kinsman et al. and Wieland et al. This involved extracting characteristics of Lean, synthesizing similar components to establish an operational definition, applying this definition, and updating the definition to address shortcomings. We identified two defining characteristics of Lean health-care management: (1) Lean philosophy, consisting of Lean principles and continuous improvement, and (2) Lean activities, which include Lean assessment activities and Lean improvement activities. The resulting operational definition requires that an organization or subunit of an organization had integrated Lean philosophy into the organization's mandate, guidelines, or policies and utilized at least one Lean assessment activity or Lean improvement activity. This operational definition of Lean management in health care will act as an objective screening criterion for our systematic review. To our knowledge, this is the first evidence-based operational definition of Lean management in health care.

In vivo synthesis of nano-selenium by Tetrahymena thermophila SB210.

PubMed

Cui, Yin-Hua; Li, Ling-Li; Zhou, Nan-Qing; Liu, Jing-Hua; Huang, Qing; Wang, Hui-Juan; Tian, Jie; Yu, Han-Qing

2016-12-01

Nano-selenium has a great potential to be used in chemical, biological, medical and environmental fields. Biological methods for nano-selenium synthesis have attracted wide interests, because they can be operated at ambient temperature and pressure without complicated equipments. In this work, a protozoa, Tetrahymena thermophila (T. thermophila) SB210, was used to in vivo synthesize nano-selenium. The biosynthesized nano-selenium was characterized using transmission electron microscopy, energy dispersive X-ray spectroscopy and Raman spectroscopy. The synthesized amorphous spherical selenium nanoparticles had diameters of 50-500nm with the coexistence of irregular nano-selenium. The expressions of glutathione (GSH) synthesis related gene glutathione synthase, cysteine-rich protein metallothionein related gene metallothionein-1 and [2Fe-2S] cluster-binding protein related gene were up-regulated in the nano-selenium producing group. Also, the subsequent GSH detection and in vitro synthesis experimental results suggest the three proteins were likely to be involved in the nano-selenium synthesis process. Copyright © 2016 Elsevier Inc. All rights reserved.

Options for Synthetic DNA Order Screening, Revisited.

PubMed

DiEuliis, Diane; Carter, Sarah R; Gronvall, Gigi Kwik

2017-01-01

Gene synthesis providers affiliated with the International Gene Synthesis Consortium (IGSC) voluntarily screen double-stranded DNA (dsDNA) synthesis orders over 200 bp to check for matches to regulated pathogens and to screen customers. Questions have been raised, however, about the continuing feasibility and effectiveness of screening. There are technical challenges (e.g., oligonucleotides and tracts of DNA less than 200 bp are not screened) and corporate challenges (e.g., the costs of screening are high, but other costs are dropping, so screening is an increasing portion of operating costs). In this article, we describe tangible actions that should be taken to (i) preserve the effectiveness of DNA order screening as a security tool and (ii) develop additional mechanisms to increase the safety and security of DNA synthesis technologies. Screening is not a perfect solution to DNA synthesis security challenges, but we believe it is still a valuable addition to security, and it can remain effective for some time.

Divergent Synthesis of Heparan Sulfate Oligosaccharides

PubMed Central

2015-01-01

Heparan sulfates are implicated in a wide range of biological processes. A major challenge in deciphering their structure and activity relationship is the synthetic difficulties to access diverse heparan sulfate oligosaccharides with well-defined sulfation patterns. In order to expedite the synthesis, a divergent synthetic strategy was developed. By integrating chemical synthesis and two types of O-sulfo transferases, seven different hexasaccharides were obtained from a single hexasaccharide precursor. This approach combined the flexibility of chemical synthesis with the selectivity of enzyme-catalyzed sulfations, thus simplifying the overall synthetic operations. In an attempt to establish structure activity relationships of heparan sulfate binding with its receptor, the synthesized oligosaccharides were incorporated onto a glycan microarray, and their bindings with a growth factor FGF-2 were examined. The unique combination of chemical and enzymatic approaches expanded the capability of oligosaccharide synthesis. In addition, the well-defined heparan sulfate structures helped shine light on the fine substrate specificities of biosynthetic enzymes and confirm the potential sequence of enzymatic reactions in biosynthesis. PMID:26574650

Ohmic Heating: An Emerging Concept in Organic Synthesis.

PubMed

Silva, Vera L M; Santos, Luis M N B F; Silva, Artur M S

2017-06-12

The ohmic heating also known as direct Joule heating, is an advanced thermal processing method, mainly used in the food industry to rapidly increase the temperature for either cooking or sterilization purposes. Its use in organic synthesis, in the heating of chemical reactors, is an emerging method that shows great potential, the development of which has started recently. This Concept article focuses on the use of ohmic heating as a new tool for organic synthesis. It presents the fundamentals of ohmic heating and makes a qualitative and quantitative comparison with other common heating methods. A brief description of the ohmic reactor prototype in operation is presented as well as recent examples of its use in organic synthesis at laboratory scale, thus showing the current state of the research. The advantages and limitations of this heating method, as well as its main current applications are also discussed. Finally, the prospects and potential implications of ohmic heating in future research in chemical synthesis are proposed. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Alcohol synthesis in a high-temperature slurry reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, G.W.; Marquez, M.A.; McCutchen, M.S.

1995-12-31

The overall objective of this contract is to develop improved process and catalyst technology for producing higher alcohols from synthesis gas or its derivatives. Recent research has been focused on developing a slurry reactor that can operate at temperatures up to about 400{degrees}C and on evaluating the so-called {open_quotes}high pressure{close_quotes} methanol synthesis catalyst using this reactor. A laboratory stirred autoclave reactor has been developed that is capable of operating at temperatures up to 400{degrees}C and pressures of at least 170 atm. The overhead system on the reactor is designed so that the temperature of the gas leaving the system canmore » be closely controlled. An external liquid-level detector is installed on the gas/liquid separator and a pump is used to return condensed slurry liquid from the separator to the reactor. In order to ensure that gas/liquid mass transfer does not influence the observed reaction rate, it was necessary to feed the synthesis gas below the level of the agitator. The performance of a commercial {open_quotes}high pressure {close_quotes} methanol synthesis catalyst, the so-called {open_quotes}zinc chromite{close_quotes} catalyst, has been characterized over a range of temperature from 275 to 400{degrees}C, a range of pressure from 70 to 170 atm., a range of H{sub 2}/CO ratios from 0.5 to 2.0 and a range of space velocities from 2500 to 10,000 sL/kg.(catalyst),hr. Towards the lower end of the temperature range, methanol was the only significant product.« less

Translational autocontrol of the Escherichia coli ribosomal protein S15.

PubMed

Portier, C; Dondon, L; Grunberg-Manago, M

1990-01-20

When rpsO, the gene encoding the ribosomal protein S15 in Escherichia coli, is carried by a multicopy plasmid, the mRNA synthesis rate of S15 increases with the gene dosage but the rate of synthesis of S15 does not rise. A translational fusion between S15 and beta-galactosidase was introduced on the chromosome in a delta lac strain and the expression of beta-galactosidase studied under different conditions. The presence of S15 in trans represses the beta-galactosidase level five- to sixfold, while the synthesis rate of the S15-beta-galactosidase mRNA decreases by only 30 to 50%. These data indicate that S15 is subject to autogenous translational control. Derepressed mutants were isolated and sequenced. All the point mutations map in the second codon of S15, suggesting a location for the operator site that is very near to the translation initiation codon. However, the creation of deletion mutations shows that the operator extends into the 5' non-coding part of the message, thus overlapping the ribosome loading site.

Automation of multi-agent control for complex dynamic systems in heterogeneous computational network

NASA Astrophysics Data System (ADS)

Oparin, Gennady; Feoktistov, Alexander; Bogdanova, Vera; Sidorov, Ivan

2017-01-01

The rapid progress of high-performance computing entails new challenges related to solving large scientific problems for various subject domains in a heterogeneous distributed computing environment (e.g., a network, Grid system, or Cloud infrastructure). The specialists in the field of parallel and distributed computing give the special attention to a scalability of applications for problem solving. An effective management of the scalable application in the heterogeneous distributed computing environment is still a non-trivial issue. Control systems that operate in networks, especially relate to this issue. We propose a new approach to the multi-agent management for the scalable applications in the heterogeneous computational network. The fundamentals of our approach are the integrated use of conceptual programming, simulation modeling, network monitoring, multi-agent management, and service-oriented programming. We developed a special framework for an automation of the problem solving. Advantages of the proposed approach are demonstrated on the parametric synthesis example of the static linear regulator for complex dynamic systems. Benefits of the scalable application for solving this problem include automation of the multi-agent control for the systems in a parallel mode with various degrees of its detailed elaboration.

Savannah River Ecology Laboratory. Annual technical progress report of ecological research, period ending July 31, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-07-31

The Savannah River Ecology Laboratory (SREL) is a research unit of the University of Georgia (UGA) that is managed in conjunction with the University`s Institute of Ecology. The laboratory`s overall mission is to acquire and communicate knowledge of ecological processes and principles. SREL conducts basic and applied ecological research, as well as education and outreach programs, under an M&O contract with the US Department of Energy at the Savannah River Site. Significant accomplishments were made during the year ending July 31, 1994 in the areas of research, education and service. Reviewed in this document are research projects in the followingmore » areas: Environmental Operations Support (impacted wetlands, streams, trace organics, radioecology, database synthesis, wild life studies, zooplankton, safety and quality assurance); wood stork foraging and breeding ecology; defence waste processing facility; environmental risk assessment (endangered species, fish, ash basin studies); ecosystem alteration by chemical pollutants; wetlands systems; biodiversity on the SRS; Environmental toxicology; environmental outreach and education; Par Pond drawdown studies in wildlife and fish and metals; theoretical ecology; DOE-SR National Environmental Research Park; wildlife studies. Summaries of educational programs and publications are also give.« less

Network Plus

NASA Astrophysics Data System (ADS)

Bender, Walter; Chesnais, Pascal

1988-05-01

Over the past several years, the Electronic Publishing Group at the MIT Media Laboratory has been conducting a family of media experiments which explore a new kind of broadcast: the distribution of data and computer programs rather than pre-packaged material. This broadcast is not directed to a human recipient, but to a local computational agent acting on his behalf. In response to instructions from both the broadcaster and the reader, this agent selects from the incoming data and presents it in a manner suggestive of traditional media. The embodiment of these media experiments is a news retrieval system where the news editor has been replaced by the personal computer. A variety of both local and remote databases which operate passively as well as interac-tively are accessed by "reporters." These "reporters" are actually software interfaces, which are programmed to gather news. Ideally, they are "broadcatching" that is to say, watching all broadcast television channels, listening to all radio transmissions, and reading all newspapers, magazines, and journals. 1 A possible consequence of the synthesis of media through active processing is the merger of newspapers and television (figure 1). The result is either a newspaper with illustrations which move 2 or, conversely, print as television output. The latter is the theme of Network Plus.

Design and Operation of the Synthesis Gas Generator System for Reformed Propane and Glycerin Combustion

NASA Astrophysics Data System (ADS)

Pickett, Derek Kyle

Due to an increased interest in sustainable energy, biodiesel has become much more widely used in the last several years. Glycerin, one major waste component in biodiesel production, can be converted into a hydrogen rich synthesis gas to be used in an engine generator to recover energy from the biodiesel production process. This thesis contains information detailing the production, testing, and analysis of a unique synthesis generator rig at the University of Kansas. Chapter 2 gives a complete background of all major components, as well as how they are operated. In addition to component descriptions, methods for operating the system on pure propane, reformed propane, reformed glycerin along with the methodology of data acquisition is described. This chapter will serve as a complete operating manual for future students to continue research on the project. Chapter 3 details the literature review that was completed to better understand fuel reforming of propane and glycerin. This chapter also describes the numerical model produced to estimate the species produced during reformation activities. The model was applied to propane reformation in a proof of concept and calibration test before moving to glycerin reformation and its subsequent combustion. Chapter 4 first describes the efforts to apply the numerical model to glycerin using the calibration tools from propane reformation. It then discusses catalytic material preparation and glycerin reformation tests. Gas chromatography analysis of the reformer effluent was completed to compare to theoretical values from the numerical model. Finally, combustion of reformed glycerin was completed for power generation. Tests were completed to compare emissions from syngas combustion and propane combustion.

Nicholas Cleveland | NREL

Science.gov Websites

tools for complex sample analysis Affiliated Research Programs Biochemical Catalysis Working Group The synthesis Catalyst characterization Catalyst testing and reaction screening Analysis of complex organics

49 CFR 192.913 - When may an operator deviate its program from certain requirements of this subpart?

Code of Federal Regulations, 2011 CFR

2011-10-01

... management program. An operator that uses a performance-based approach that satisfies the requirements for... to demonstrate the exceptional performance of its integrity management program through the following... to the operator's pipeline system and to the operator's integrity management program; (vi) A...

77 FR 43084 - Multiple Award Schedule (MAS) Program Continuous Open Season-Operational Change

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-23

... Award Schedule (MAS) Program Continuous Open Season- Operational Change AGENCY: Federal Acquisition... proposing this operational change to enhance the performance of and modernize the MAS program in three key program areas: Small business viability, operational efficiency, and cost control. The DBM will realign...

Lunar Production and Application of Solar Cells, and Synthesis of Diamond Film

NASA Technical Reports Server (NTRS)

Fang, P. H.

1991-01-01

Two projects which are carried out under the Summer Faculty Fellowship Program-1991 are discussed. A conceptual design of a solar cell manufacturing plant on a lunar base is discussed. This is a large program that requires a continuous and expanded effort, the present status of which is reflected here. An experiment on the synthesis of diamond film is discussed. Encouraging, but not yet conclusive evidence has been obtained on a new method to synthesize diamond film. The procedures and observations are presented. A third project is an analysis of the solar cell performance over five years on the moon based on Apollo missions. A paper has been completed and will be submitted to the journal Solar Cells for publication.

Nanostructured materials: A novel approach to enhanced performance. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korth, G.E.; Froes, F.H.; Suryanarayana, C.

Nanostuctured materials are an emerging class of materials that can exhibit physical and mechanical characteristics often exceeding those exhibited by conventional course grained materials. A number of different techniques can be employed to produce these materials. In this program, the synthesis methods were (a) mechanical alloying , (b) physical vapor deposition, and (c) plasma processing. The physical vapor deposition and plasma processing were discontinued after initial testing with subsequent efforts focused on mechanical alloying. The major emphasis of the program was on the synthesis, consolidation, and characterization of nanostructured Al-Fe, Ti-Al, Ti-Al-Nb, and Fe-Al by alloying intermetallics with a viewmore » to increase their ductilities. The major findings of this project are reported.« less

Exploiting basic principles to control the selectivity of the vapor phase catalytic oxidative cross-coupling of primary alcohols over nanoporous gold catalysts

DOE PAGES

Wang, Lu-Cun; Stowers, Kara J.; Zugic, Branko; ...

2015-05-20

It is important to achieve high selectivity for high volume chemical synthesis in order to lower energy consumption through reduction in waste. Here, we report the selective synthesis of methyl esters—methyl acetate and methyl butyrate—through catalytic O 2-assisted cross-coupling of methanol with ethanol or 1-butanol using activated, support-free nanoporous gold (npAu). Both well-controlled studies on ingots in UHV and experiments under ambient pressure catalytic conditions on both ingots and microspherical hollow shell catalysts reveal guiding principles for controlling selectivity. Under UHV conditions, the ester products of the cross-coupling of methanol with both ethanol and 1-butanol evolve near room temperature inmore » temperature-programmed reaction studies, indicating that the reactions occur facilely. Furthermore, under steady-state catalytic operation, high stable activity was observed for cross-coupling in flowing gaseous reactant mixtures at atmospheric pressure and 423 K with negligible combustion. Optimum selectivity for cross-coupling is obtained in methanol-rich mixtures due to a combination of two factors: (1) the relative coverage of the respective alkoxys and (2) the relative facility of their β-H elimination. The relative coverage of the alkoxys is governed by van der Waal’s interactions between the alkyl groups and the surface; here, we demonstrate the importance of these weak interactions in a steady-state catalytic process.« less

An Approach Toward Synthesis of Bridgmanite in Dynamic Compression Experiments

NASA Astrophysics Data System (ADS)

Reppart, J. J.

2015-12-01

Bridgmanite occurs in heavily shocked meteorites and provides a useful constraint on pressure-temperature conditions during shock-metamorphism. Its occurrence also provides constraints on the shock release path. Shock-release and shock duration are important parameters in estimating the size of impactors that generate the observed shock metamorphic record. Thus, it is timely to examine if bridgmanite can be synthesized in dynamic compression experiments with the goal of establishing a correlation between shock duration and grainsize. Up to now only one high pressure polymorph of an Mg-silicate has been synthesized AND recovered in a shock experiment (wadsleyite). Therefore, it is not given that shock synthesis of bridgmanite is possible. This project started recently, so we present an outline of shock experiment designs and potentially results from the first experiments. FUNDING ACKNOWLEDGMENT UNLV HiPSEC: This research was sponsored (or sponsored in part) by the National Nuclear Security Administration under the Stewardship Science Academic Alliances program through DOE Cooperative Agreement #DE-NA0001982. HPCAT: "[Portions of this work were]/[This work was] performed at HPCAT (Sector 16), Advanced Photon Source (APS), Argonne National Laboratory. HPCAT operations are supported by DOE-NNSA under Award No. DE-NA0001974 and DOE-BES under Award No. DE-FG02-99ER45775, with partial instrumentation funding by NSF. APS is supported by DOE-BES, under Contract No. DE-AC02-06CH11357."

Engineering Graphene Films from Coal

NASA Astrophysics Data System (ADS)

Vijapur, Santosh H.

Graphene is a unique material with remarkable properties suitable for a wide array of applications. Chemical vapor deposition (CVD) is a simple technique for synthesis of large area and high quality graphene films on various metal substrates. Among the metal substrates, copper has been shown to be an excellent support for the growth of graphene films. Traditionally, hydrocarbon gases are used for the graphene synthesis via CVD. Unconventional solid carbon sources such as various polymers and food waste have also shown great potential for synthesis of graphene films. Coal is one such carbon enriched and abundantly available unconventional source. Utilization of coal as a carbon source to synthesize large area, transparent, and high quality few-layer graphene films via CVD has been demonstrated in the present work. Hydrocarbon gases are released as products of coal pyrolysis at temperatures ≥400 °C. This study hypothesized that, these hydrocarbon gases act as precursors for the synthesis of graphene films on the copper substrate. Hence, atmospheric pressure CVD and low temperature of 400 °C were utilized initially for the production of graphene films. These conditions were suitable for the formation of amorphous carbon (a-C) films but not crystalline graphene films that were the objective of this work. The synthesized a-C films on the copper substrate were shown to be uniform and transparent with large surface area. The thickness and surface roughness of the a-C films were determined to have typical values of 5 nm and 0.55 nm, respectively. The a-C film has >95 % optical transmittance and sheet resistivity of 0.6 MO sq-1. These values are comparable to other carbon thin films synthesized at higher temperatures. Further, the a-C films were transferred onto any type of substrate such as silicon wafer and titanium foil, and can be utilized for diverse applications. However, crystalline graphene films were not produced by implementing atmospheric pressure CVD and low temperature operation. Annealing of copper support was required to remove the oxide layer present on its surface and low pressure operation was demonstrated to be suitable for crystalline graphene film formation. The CVD system and the synthesis procedure were modified to address these issues. This was done by increasing the synthesis temperature, incorporating a vacuum pump for low pressure operation, and implementing two step procedure of annealing the copper substrate followed by subsequent coal pyrolysis for the synthesis of crystalline graphene films. The synthesized few layer graphene films were uniform and continuous with thickness in the range of 3-7 nm. The optical transmittance and electrical conductivity measurements demonstrated that the graphene films have >95 % transparency and sheet resistivity of 5.0 kO sq-1, respectively. An investigation of growth mechanism of coal derived graphene films synthesized via CVD was conducted utilizing spectroscopy, microscopy, and chromatography techniques. Gas collection was performed at the graphene synthesis conditions utilizing the CVD reactor without vacuum in operation. Various gases released as products of coal pyrolysis in the CVD reactor were collected and analyzed using gas chromatography. The analysis showed the presence of methane, ethane, ethene, propane, propene, carbon monoxide, and carbon dioxide as coal pyrolysis products. The hydrocarbon gases act as precursors for graphene growth. Raman spectroscopy, selected area electron diffraction (SAED), and X-ray photoelectron spectroscopy (XPS) confirmed the formation of crystalline graphene films at 1055 °C and 18-30 min synthesis. The growth mechanism involves copper catalyzed reaction to produce amorphous carbon film within the first few minutes of synthesis. Raman spectroscopy and SAED validated that lower synthesis times (6-12 min) produced hybrid amorphous carbon films. This is followed by hydrogen catalyzed graphitization of the underlying carbon film to form graphene domains. Optical microscopy and Raman spectra demonstrated the formation of these oval shaped graphene domains as synthesis time was increased (18-30 min). The graphene films are formed by growth and merging of these graphene domains on the copper substrate. The growth mechanism of coal derived crystalline graphene films is presented in the current work.

The integrated manual and automatic control of complex flight systems

NASA Technical Reports Server (NTRS)

Schmidt, D. K.

1986-01-01

The topics of research in this program include pilot/vehicle analysis techniques, identification of pilot dynamics, and control and display synthesis techniques for optimizing aircraft handling qualities. The project activities are discussed. The current technical activity is directed at extending and validating the active display synthesis procedure, and the pilot/vehicle analysis of the NLR rate-command flight configurations in the landing task. Two papers published by the researchers are attached as appendices.

Undergraduate HBCU Student Summer Training Program for Developing Nanomedicines to Treat Prostate Cancers

DTIC Science & Technology

2016-08-01

and interpret generated MS data. She also got familiarized with synthesis of HPMA polymer and conjugation of targeted peptide to the polymer . During...techniques (Ciera), polymer synthesis and nanomedicine development (Starr and Andrea), the effect of drug treatment on prostate cancer cells (My’Chelle...career in the field of prostate cancer. W81XWH-15-1-0202 15. SUBJECT TERMS Prostate cancer, co- polymer , anti-androgen, peptide-based targeting

A spectrum synthesis program for binary stars

NASA Technical Reports Server (NTRS)

Linnell, Albert P.; Hubeny, Ivan

1994-01-01

A new program produces synthetic spectra of binary stars at arbitrary values of orbital longitude, including longitudes of partial or complete eclipse. The stellar components may be distorted, either tidally or rotationally, or both. Either or both components may be rotating nonsynchronously. We illustrate the program performance with two cases: EE Peg, an eclipsing binary with small distortion, and SX Aur, an eclipsing binary that is close to contact.

Automated predesign of aircraft

NASA Technical Reports Server (NTRS)

Poe, C. C., Jr.; Kruse, G. S.; Tanner, C. J.; Wilson, P. J.

1978-01-01

Program uses multistation structural-synthesis to size and design box-beam structures for transport aircraft. Program optimizes static strength and scales up to satisfy fatigue and fracture criteria. It has multimaterial capability and library of materials properties, including advanced composites. Program can be used to evaluate impact on weight of variables such as materials, types of construction, structural configurations, minimum gage limits, applied loads, fatigue lives, crack-growth lives, initial crack sizes, and residual strengths.

Design Conference for the Evaluation of the Talent Search Program: Synthesis of Major Themes and Commissioned Papers Prepared for the Conference (Washington, D.C., September 30, 1992).

ERIC Educational Resources Information Center

Westat, Inc., Rockville, MD.

This report gathers papers prepared for a design conference for the evaluation of the Federal Talent Search Program, an early intervention program to identify gifted and talented financially needy students and connect them with discretionary grants for higher education. An introductory paper synthesizes major conference themes. These include: (1)…

Electronic materials high-T(sub c) superconductivity polymers and composites structural materials surface science and catalysts industry participation

NASA Technical Reports Server (NTRS)

1988-01-01

The fifth year of the Center for Advanced Materials was marked primarily by the significant scientific accomplishments of the research programs. The Electronics Materials program continued its work on the growth and characterization of gallium arsenide crystals, and the development of theories to understand the nature and distribution of defects in the crystals. The High Tc Superconductivity Program continued to make significant contributions to the field in theoretical and experimental work on both bulk materials and thin films and devices. The Ceramic Processing group developed a new technique for cladding YBCO superconductors for high current applications in work with the Electric Power Research Institute. The Polymers and Composites program published a number of important studies involving atomistic simulations of polymer surfaces with excellent correlations to experimental results. The new Enzymatic Synthesis of Materials project produced its first fluorinated polymers and successfully began engineering enzymes designed for materials synthesis. The structural Materials Program continued work on novel alloys, development of processing methods for advanced ceramics, and characterization of mechanical properties of these materials, including the newly documented characterization of cyclic fatigue crack propagation behavior in toughened ceramics. Finally, the Surface Science and Catalysis program made significant contributions to the understanding of microporous catalysts and the nature of surface structures and interface compounds.

Integrated Platform for Expedited Synthesis–Purification–Testing of Small Molecule Libraries

PubMed Central

2017-01-01

The productivity of medicinal chemistry programs can be significantly increased through the introduction of automation, leading to shortened discovery cycle times. Herein, we describe a platform that consolidates synthesis, purification, quantitation, dissolution, and testing of small molecule libraries. The system was validated through the synthesis and testing of two libraries of binders of polycomb protein EED, and excellent correlation of obtained data with results generated through conventional approaches was observed. The fully automated and integrated platform enables batch-supported compound synthesis based on a broad array of chemical transformations with testing in a variety of biochemical assay formats. A library turnaround time of between 24 and 36 h was achieved, and notably, each library synthesis produces sufficient amounts of compounds for further evaluation in secondary assays thereby contributing significantly to the shortening of medicinal chemistry discovery cycles. PMID:28435537

Science/Technology/Society. Focus on Excellence, Volume 1, Number 5.

ERIC Educational Resources Information Center

Penick, John E., Ed.; Meinhard-Pellens, Richard, Ed.

This document describes 10 examples of innovative and outstanding science/technology/society (STS) programs. These programs were selected using state criteria and at least four independent reviewers. While Project Synthesis offered a desired state, these examples of excellence provided views of what is already a reality. The goals of an exemplary…

Effective Programs for Struggling Readers: A Best-Evidence Synthesis. [Educator's Summary

ERIC Educational Resources Information Center

Center for Data-Driven Reform in Education, 2009

2009-01-01

Which elementary reading approaches have been proven to help struggling readers to succeed? To find out, this review summarizes evidence on six types of programs designed to improve the reading achievement of children having difficulty in learning to read: (1) One-to-One Tutoring by Teachers (TT) such as "Reading Recovery," "Auditory…

Health and Fitness Through Physical Activity.

ERIC Educational Resources Information Center

Pollock, Michael L.; And Others

A synthesis of research findings in exercise and physical fitness is presented to provide the general public with insights into establishing an individualized exercise program. The material is divided into seven subtopics: (1) a general overview of the need for exercise and fitness and how it is an integral part of preventive medicine programs;…

Increasing the Effectiveness of Inservice Training for Desegregation: A Synthesis of Current Research. Reference & Resource Series.

ERIC Educational Resources Information Center

Smylie, Mark A.; Hawley, Willis D.

This report reviews recent research on strategies that have been found to promote useful and effective inservice training programs in desegregated schools. The first section presents approaches for planning and implementing inservice training for desegregation. The second section describes inservice desegregation training programs that focus on:…

An acceptable role for computers in the aircraft design process

NASA Technical Reports Server (NTRS)

Gregory, T. J.; Roberts, L.

1980-01-01

Some of the reasons why the computerization trend is not wholly accepted are explored for two typical cases: computer use in the technical specialties and computer use in aircraft synthesis. The factors that limit acceptance are traced in part, to the large resources needed to understand the details of computer programs, the inability to include measured data as input to many of the theoretical programs, and the presentation of final results without supporting intermediate answers. Other factors are due solely to technical issues such as limited detail in aircraft synthesis and major simplifying assumptions in the technical specialties. These factors and others can be influenced by the technical specialist and aircraft designer. Some of these factors may become less significant as the computerization process evolves, but some issues, such as understanding large integrated systems, may remain issues in the future. Suggestions for improved acceptance include publishing computer programs so that they may be reviewed, edited, and read. Other mechanisms include extensive modularization of programs and ways to include measured information as part of the input to theoretical approaches.

Synthesis of Hadamard transformers by use of multimode interference optical waveguides.

PubMed

Gupta, Atma Ram; Tsutsumi, Kiyoshi; Nakayama, Junichi

2003-05-20

We propose a synthesis method of optical Hadamard transformer using multimode interference (MMI) couplers. By using the signal transfer matrix of 2 x 2, 4 x 4, and 8 x 8 MMI couplers, we show that sum and difference units of input signals can be synthesized. An interchange unit of two signals can also be synthesized. One synthesis method of Hadamard transformers is a combination of only 2 x 2 units, and the other is a combination of N x N(N > or = 4) units as well as 2 x 2 units. The design examples of operation units are shown, and the size and the output power of Hadamard transformers are estimated.

Method and apparatus for producing synthesis gas

DOEpatents

Hemmings, John William; Bonnell, Leo; Robinson, Earl T.

2010-03-03

A method and apparatus for reacting a hydrocarbon containing feed stream by steam methane reforming reactions to form a synthesis gas. The hydrocarbon containing feed is reacted within a reactor having stages in which the final stage from which a synthesis gas is discharged incorporates expensive high temperature materials such as oxide dispersed strengthened metals while upstream stages operate at a lower temperature allowing the use of more conventional high temperature alloys. Each of the reactor stages incorporate reactor elements having one or more separation zones to separate oxygen from an oxygen containing feed to support combustion of a fuel within adjacent combustion zones, thereby to generate heat to support the endothermic steam methane reforming reactions.

THE EDUCATIONAL INSTITUTION AS A SYSTEM--A PROPOSED GENERALIZED PROCEDURE FOR ANALYSIS.

ERIC Educational Resources Information Center

REISMAN, ARNOLD; TAFT, MARTIN I.

A UNIFIED APPROACH TO THE ANALYSIS AND SYNTHESIS OF THE FUNCTIONS AND OPERATIONS IN EDUCATIONAL INSTITUTIONS IS PRESENTED. SYSTEMS ANALYSIS TECHNIQUES USED IN OTHER AREAS SUCH AS CRAFT, PERT, CERBS, AND OPERATIONS RESEARCH ARE SUGGESTED AS POTENTIALLY ADAPTABLE FOR USE IN HIGHER EDUCATION. THE MAJOR OBJECTIVE OF A SCHOOL IS TO ALLOCATE AVAILABLE…

Discrete-continuous variable structural synthesis using dual methods

NASA Technical Reports Server (NTRS)

Schmit, L. A.; Fleury, C.

1980-01-01

Approximation concepts and dual methods are extended to solve structural synthesis problems involving a mix of discrete and continuous sizing type of design variables. Pure discrete and pure continuous variable problems can be handled as special cases. The basic mathematical programming statement of the structural synthesis problem is converted into a sequence of explicit approximate primal problems of separable form. These problems are solved by constructing continuous explicit dual functions, which are maximized subject to simple nonnegativity constraints on the dual variables. A newly devised gradient projection type of algorithm called DUAL 1, which includes special features for handling dual function gradient discontinuities that arise from the discrete primal variables, is used to find the solution of each dual problem. Computational implementation is accomplished by incorporating the DUAL 1 algorithm into the ACCESS 3 program as a new optimizer option. The power of the method set forth is demonstrated by presenting numerical results for several example problems, including a pure discrete variable treatment of a metallic swept wing and a mixed discrete-continuous variable solution for a thin delta wing with fiber composite skins.

Synthesis of concentric circular antenna arrays using dragonfly algorithm

NASA Astrophysics Data System (ADS)

Babayigit, B.

2018-05-01

Due to the strong non-linear relationship between the array factor and the array elements, concentric circular antenna array (CCAA) synthesis problem is challenging. Nature-inspired optimisation techniques have been playing an important role in solving array synthesis problems. Dragonfly algorithm (DA) is a novel nature-inspired optimisation technique which is based on the static and dynamic swarming behaviours of dragonflies in nature. This paper presents the design of CCAAs to get low sidelobes using DA. The effectiveness of the proposed DA is investigated in two different (with and without centre element) cases of two three-ring (having 4-, 6-, 8-element or 8-, 10-, 12-element) CCAA design. The radiation pattern of each design cases is obtained by finding optimal excitation weights of the array elements using DA. Simulation results show that the proposed algorithm outperforms the other state-of-the-art techniques (symbiotic organisms search, biogeography-based optimisation, sequential quadratic programming, opposition-based gravitational search algorithm, cat swarm optimisation, firefly algorithm, evolutionary programming) for all design cases. DA can be a promising technique for electromagnetic problems.

Mechanism of plant-mediated synthesis of silver nanoparticles - A review on biomolecules involved, characterisation and antibacterial activity.

PubMed

Rajeshkumar, S; Bharath, L V

2017-08-01

Engineering a reliable and eco-accommodating methodology for the synthesis of metal nanoparticles is a crucial step in the field of nanotechnology. Plant-mediated synthesis of metal nanoparticles has been developed as a substitute to defeat the limitations of conventional synthesis approaches such as physical and chemical methods. Biomolecules, such as proteins, amino acids, enzymes, flavonoids, and terpenoids from several plant extracts have been used as a stabilising and reducing agents for the synthesis of AgNPs. Regardless of an extensive range of biomolecules assistance in the synthesis procedure, researchers are facing a significant challenge to synthesise stable and geometrically controlled AgNPs. In the past decade, several efforts were made to develop Plant-mediated synthesis methods to produce stable, cost effective and eco-friendly AgNPs. More than hundred different plants extract sources for synthesising AgNPs were described in the last decade by several researchers. Most of the reviews were focused on various plant sources for synthesis, various characterization techniques for characteristic analysis, and antibacterial activity against bacterial. There are many reviews are available for the plant-mediated synthesis of AgNPs as well as antibacterial activity of AgNPs but this is the first review article mainly focused on biomolecules of plants and its various parts and operating conditions involved in the synthesis. Apart from, this review includes the characterisation of AgNPs and antibacterial activity of such nanoparticles with size, shape and method used for this study. Copyright © 2017 Elsevier B.V. All rights reserved.

Nano-Electronics and Bio-Electronics

NASA Technical Reports Server (NTRS)

Srivastava, Deepak; Kwak, Dochan (Technical Monitor)

2001-01-01

Viewgraph presentation on Nano-Electronics and Bio-Electronics is discussed. Topics discussed include: NASA Ames nanotechnology program, Potential Carbon Nanotube (CNT) application, CNT synthesis,Computational Nanotechnology, and protein nanotubes.

40 CFR 72.70 - Relationship to title V operating permit program.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.70 Relationship to... operating permit programs and acceptance of State Acid Rain programs, the procedure for including State Acid... of an accepted State program, to issue Phase II Acid Rain permits. (b) Relationship to operating...

40 CFR 72.70 - Relationship to title V operating permit program.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.70 Relationship to... operating permit programs and acceptance of State Acid Rain programs, the procedure for including State Acid... of an accepted State program, to issue Phase II Acid Rain permits. (b) Relationship to operating...

40 CFR 72.70 - Relationship to title V operating permit program.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.70 Relationship to... operating permit programs and acceptance of State Acid Rain programs, the procedure for including State Acid... of an accepted State program, to issue Phase II Acid Rain permits. (b) Relationship to operating...

40 CFR 72.70 - Relationship to title V operating permit program.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.70 Relationship to... operating permit programs and acceptance of State Acid Rain programs, the procedure for including State Acid... of an accepted State program, to issue Phase II Acid Rain permits. (b) Relationship to operating...

40 CFR 72.70 - Relationship to title V operating permit program.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.70 Relationship to... operating permit programs and acceptance of State Acid Rain programs, the procedure for including State Acid... of an accepted State program, to issue Phase II Acid Rain permits. (b) Relationship to operating...

A new implementation of the programming system for structural synthesis (PROSSS-2)

NASA Technical Reports Server (NTRS)

Rogers, James L., Jr.

1984-01-01

This new implementation of the PROgramming System for Structural Synthesis (PROSSS-2) combines a general-purpose finite element computer program for structural analysis, a state-of-the-art optimization program, and several user-supplied, problem-dependent computer programs. The results are flexibility of the optimization procedure, organization, and versatility of the formulation of constraints and design variables. The analysis-optimization process results in a minimized objective function, typically the mass. The analysis and optimization programs are executed repeatedly by looping through the system until the process is stopped by a user-defined termination criterion. However, some of the analysis, such as model definition, need only be one time and the results are saved for future use. The user must write some small, simple FORTRAN programs to interface between the analysis and optimization programs. One of these programs, the front processor, converts the design variables output from the optimizer into the suitable format for input into the analyzer. Another, the end processor, retrieves the behavior variables and, optionally, their gradients from the analysis program and evaluates the objective function and constraints and optionally their gradients. These quantities are output in a format suitable for input into the optimizer. These user-supplied programs are problem-dependent because they depend primarily upon which finite elements are being used in the model. PROSSS-2 differs from the original PROSSS in that the optimizer and front and end processors have been integrated into the finite element computer program. This was done to reduce the complexity and increase portability of the system, and to take advantage of the data handling features found in the finite element program.

Natural product-inspired cascade synthesis yields modulators of centrosome integrity.

PubMed

Dückert, Heiko; Pries, Verena; Khedkar, Vivek; Menninger, Sascha; Bruss, Hanna; Bird, Alexander W; Maliga, Zoltan; Brockmeyer, Andreas; Janning, Petra; Hyman, Anthony; Grimme, Stefan; Schürmann, Markus; Preut, Hans; Hübel, Katja; Ziegler, Slava; Kumar, Kamal; Waldmann, Herbert

2011-12-25

In biology-oriented synthesis, the scaffolds of biologically relevant compound classes inspire the synthesis of focused compound collections enriched in bioactivity. This criterion is, in particular, met by the scaffolds of natural products selected in evolution. The synthesis of natural product-inspired compound collections calls for efficient reaction sequences that preferably combine multiple individual transformations in one operation. Here we report the development of a one-pot, twelve-step cascade reaction sequence that includes nine different reactions and two opposing kinds of organocatalysis. The cascade sequence proceeds within 10-30 min and transforms readily available substrates into complex indoloquinolizines that resemble the core tetracyclic scaffold of numerous polycyclic indole alkaloids. Biological investigation of a corresponding focused compound collection revealed modulators of centrosome integrity, termed centrocountins, which caused fragmented and supernumerary centrosomes, chromosome congression defects, multipolar mitotic spindles, acentrosomal spindle poles and multipolar cell division by targeting the centrosome-associated proteins nucleophosmin and Crm1.

Dual catalysis for enantioselective convergent synthesis of enantiopure vicinal amino alcohols.

PubMed

Ye, Chen-Xi; Melcamu, Yared Yohannes; Li, Heng-Hui; Cheng, Jiang-Tao; Zhang, Tian-Tian; Ruan, Yuan-Ping; Zheng, Xiao; Lu, Xin; Huang, Pei-Qiang

2018-01-29

Enantiopure vicinal amino alcohols and derivatives are essential structural motifs in natural products and pharmaceutically active molecules, and serve as main chiral sources in asymmetric synthesis. Currently known asymmetric catalytic protocols for this class of compounds are still rare and often suffer from limited scope of substrates, relatively low regio- or stereoselectivities, thus prompting the development of more effective methodologies. Herein we report a dual catalytic strategy for the convergent enantioselective synthesis of vicinal amino alcohols. The method features a radical-type Zimmerman-Traxler transition state formed from a rare earth metal with a nitrone and an aromatic ketyl radical in the presence of chiral N,N'-dioxide ligands. In addition to high level of enantio- and diastereoselectivities, our synthetic protocol affords advantages of simple operation, mild conditions, high-yielding, and a broad scope of substrates. Furthermore, this protocol has been successfully applied to the concise synthesis of pharmaceutically valuable compounds (e.g., ephedrine and selegiline).

Microflow High-p,T Intensification of Vitamin D3 Synthesis Using an Ultraviolet Lamp

PubMed Central

2017-01-01

Herewith a new process concept for synthesis is presented which combines both UV-photoirradiation and high-p,T intensification (photo-high-p,T) in continuous flow. The application of this procedure to Vitamin D3 synthesis promotes thermal shifting of the equilibrium from the reaction intermediate to the product. This is enabled by microreactors which allow operation under harsh conditions such as the high temperature used here. This provides, to our best knowledge, a new kind of process combination (novel process window). As a result, in less than 1 min, 42% conversion of 7-dehydrocholesterol can be achieved giving a 17% yield and 40% selectivity of Vitamin D3. This approach enhances productivity by up to 2 orders of magnitude compared with the current capillary based vitamin D3 synthesis, because, under the microflow conditions, photochemistry can be performed at fairly high concentration and up to 20 times faster. PMID:29503521

Modular space station, phase B extension. Program operations plan

NASA Technical Reports Server (NTRS)

1971-01-01

An organized approach is defined for establishing the most significant requirements pertaining to mission operations, information management, and computer program design and development for the modular space station program. The operations plan pertains to the space station and experiment module program elements and to the ground elements required for mission management and mission support operations.

Operation Cleansweep in Florida: Extension's Role in an Environmentally Friendly Program Opportunity

ERIC Educational Resources Information Center

Fishel, Fred

2010-01-01

Operation Cleansweep is a free pesticide disposal program that has operated in Florida since 1995. The program is open to commercial facilities, including agricultural production establishments, golf course operators, and pest control companies. Since its inception, the program has had more than 1,700 participants and collected more than 1,000,000…

Operation Cleansweep in Florida: Extension's Role in an Environmental-Friendly Program Opportunity

ERIC Educational Resources Information Center

Fishel, Fred

2010-01-01

Operation Cleansweep is a free pesticide disposal program that has operated in Florida since 1995. The program is open to commercial facilities, including agricultural production establishments, golf course operators, and pest control companies. Since its inception, the program has had more than 1,700 participants and collected more than 1,000,000…

Mimetics of beta-galactosylceramide with simple ceramide substitutes: Synthesis and binding togp 120 of HIV-1, and, Enactment of chemistry knowledge by a high school student at a summer program

NASA Astrophysics Data System (ADS)

Augustin, Line A.

This thesis is the account of two research works. The first part reports the synthesis of O- and C- and aza-C-glycosides of beta-Galactosylceramide (GalCer) that contain simple ceramide substitutes, and the initial results of their binding with gp120 of HIV-1. The O-glycosides were prepared via an established procedure. The C- and aza-C-glycosides originated from a central C1-substituted galactal precursor, and their synthesis is illustrative of a potentially general method for pairs of C- and aza-C-beta-galactosides. They aza-C-glycoside with a simple C-17 hydrocarbon chain exhibited significant higher affinity than GalCer, whereas the corresponding C-glycoside was as active as GalCer. The second part describes the ethnographic study of the enactment of the chemistry knowledge of a high school student at a summer program and the influence of a cultural practice, othermothering, on her ability to perform well on her chemistry Regents Exams. Kelly, an 11th grade student exhibited very good understanding of the chemistry curriculum in the classroom, the laboratory period and the tutoring sessions where she plays a caring role for her peers. The same level of understanding was not reflected on the paper pencil exams taken during the summer program.

Benzoylurea Chitin Synthesis Inhibitors.

PubMed

Sun, Ranfeng; Liu, Chunjuan; Zhang, Hao; Wang, Qingmin

2015-08-12

Benzoylurea chitin synthesis inhibitors are widely used in integrated pest management (IPM) and insecticide resistance management (IRM) programs due to their low toxicity to mammals and predatory insects. In the past decades, a large number of benzoylurea derivatives have been synthesized, and 15 benzoylurea chitin synthesis inhibitors have been commercialized. This review focuses on the history of commercial benzolyphenylureas (BPUs), synthetic methods, structure-activity relationships (SAR), action mechanism research, environmental behaviors, and ecotoxicology. Furthermore, their disadvantages of high risk to aquatic invertebrates and crustaceans are pointed out. Finally, we propose that the para-substituents at anilide of benzoylphenylureas should be the functional groups, and bipartite model BPU analogues are discussed in an attempt to provide new insight for future development of BPUs.

Program and Abstracts, Boron Americas IX Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feakes, Debra A.

The Scientific and Technical Information (STI) submitted includes the final report and a collection of abstracts for the Ninth Boron in the Americas Conference which was held May 19-22, 2004, in San Marcos, Texas. The topics covered in the abstracts include: Application in Medicine, Application in Organic Synthesis and Catalysis, Boranes and Carboranes, Materials and Polymers, Metallaboranes and Metallacarboranes, Organoboron Compounds, Synthesis and Catalysis, and Theoretical Studies. Attendees represented researchers from government, industry, and academia.

A statistical-based scheduling algorithm in automated data path synthesis

NASA Technical Reports Server (NTRS)

Jeon, Byung Wook; Lursinsap, Chidchanok

1992-01-01

In this paper, we propose a new heuristic scheduling algorithm based on the statistical analysis of the cumulative frequency distribution of operations among control steps. It has a tendency of escaping from local minima and therefore reaching a globally optimal solution. The presented algorithm considers the real world constraints such as chained operations, multicycle operations, and pipelined data paths. The result of the experiment shows that it gives optimal solutions, even though it is greedy in nature.

Development of Highly-Conductive Polyelectrolytes for Lithium Batteries

NASA Technical Reports Server (NTRS)

Shriver, D. F.; Ratner, M. A.; Vaynman, S.; Annan, K. O.; Snyder, J. F.

2003-01-01

Future NASA and Air Force missions require reliable and safe sources of energy with high specific energy and energy density that can provide thousands of charge-discharge cycles at more than 40% depth- of-discharge and that can operate at low temperatures. All solid-state batteries have substantial advantages with respect to stability, energy density, storage fife and cyclability. Among all solid-state batteries, those with flexible polymer electrolytes offer substantial advantages in cell dimensionality and commensurability, low temperature operation and thin film design. The above considerations suggest that lithium-polymer electrolyte systems are promising for high energy density batteries and should be the systems of choice for NASA and US Air Force applications. Polyelectrolytes (single ion conductors) are among most promising avenues for achieving a major breakthrough 'in the applicability of polymer- based electrolyte systems. Their major advantages include unit transference number for the cation, reduced cell polarization, minimal salt precipitation, and favorable electrolyte stability at interfaces. Our research is focused on synthesis, modeling and cell testing of single ion carriers, polyelectrolytes. During the first year of this project we attempted the synthesis of two polyelectrolytes. The synthesis of the first one, the poly(ethyleneoxide methoxy acrylateco-lithium 1,1,2-trifluorobutanesulfonate acrylate, was attempted few times and it was unsuccessful. We followed the synthetic route described by Cowie and Spence. The yield was extremely low and the final product could not be separated from the impurities. The synthesis of this polyelectrolyte is not described in this report. The second polyelectrolyte, comb polysiloxane polyelectrolyte containing oligoether and perfluoroether sidechains, was synthesized in sufficient quantity to study the range of properties such as thermal stability, Li- ion- conductivity and stability toward lithium metal. Also, the batteries containing this polyelectrolyte were assembled and tested. The results are detailed below. The synthesis of another polyelectrolyte similar to polysiloxane polyelectrolyte has been started, however, the synthesis was not completed due to termination of the project.

78 FR 7477 - Multistate Corridor Operations and Management Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-01

... in the Multistate Corridor Operations and Management Program authorized by the Safe, Accountable... projects to improve multimodal transportation system management and operations. This notice seeks... Multistate Corridor Operations and Management (MCOM) programs and projects. The purpose of these investments...

Integrated Projectile Systems Synthesis Model (IPSSM)

DTIC Science & Technology

1976-08-01

Lethal area effectiveness Batch mode I terior ballistics Trajectory calculations Weapon system modeling ""TRACT (Cenetsmae an revers elds It ecesuy and...Ballistics (AR) 29 E. Terminal Effectiveness Calculations (LA) 31 F. 6-D Trajectory (TR) 32 G. Recoil Mechanism Design (RM) 33 H. Sabot Design (SD) 33 I...Exterior Ballistics Program (AR) 79 Key Variable Input D2 Exterior Ballistics Program (AR) 89 List of Tables E Terminal Effectiveness Program (LA) 93

Preparation of cherry-picked combinatorial libraries by string synthesis.

PubMed

Furka, Arpád; Dibó, Gábor; Gombosuren, Naran

2005-03-01

String synthesis [1-3] is an efficient and cheap manual method for preparation of combinatorial libraries by using macroscopic solid support units. Sorting the units between two synthetic steps is an important operation of the procedure. The software developed to guide sorting can be used only when complete combinatorial libraries are prepared. Since very often only selected components of the full libraries are needed, new software was constructed that guides sorting in preparation of non-complete combinatorial libraries. Application of the software is described in details.

A Bioluminometric Method of DNA Sequencing

NASA Technical Reports Server (NTRS)

Ronaghi, Mostafa; Pourmand, Nader; Stolc, Viktor; Arnold, Jim (Technical Monitor)

2001-01-01

Pyrosequencing is a bioluminometric single-tube DNA sequencing method that takes advantage of co-operativity between four enzymes to monitor DNA synthesis. In this sequencing-by-synthesis method, a cascade of enzymatic reactions yields detectable light, which is proportional to incorporated nucleotides. Pyrosequencing has the advantages of accuracy, flexibility and parallel processing. It can be easily automated. Furthermore, the technique dispenses with the need for labeled primers, labeled nucleotides and gel-electrophoresis. In this chapter, the use of this technique for different applications is discussed.

Cross-Aldol Reaction of Activated Carbonyls with Nitrosocarbonyl Intermediates: Stereoselective Synthesis toward α-Hydroxy-β-amino Esters and Amides.

PubMed

Mallik, Sumitava; Bhajammanavar, Vinod; Ramakrishna, Isai; Baidya, Mahiuddin

2017-07-21

A practical and flexible strategy toward α-hydroxy-β-amino esters and amides, which are important biological motifs, based on an organocatalytic cross-aldol reaction of in situ-generated nitrosocarbonyl intermediates followed by hydrogenation is presented. The protocol features operational simplicity, high yields, a wide substrate scope, and high regio- and diastereoselectivity profiles. The utility of this method was showcased through the synthesis of bestatin analogues and indole formation.

Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes.

PubMed

Fan, Zhoulong; Lu, Heng; Li, Wei; Geng, Kaijun; Zhang, Ao

2017-07-21

A switchable synthesis of N-substituted indole derivatives from phenidones via rhodium-catalyzed redox-neutral C-H activation has been achieved. In this protocol, we firstly disclosed that the reactivity of Rh(iii) catalysis could be enhanced through employing palladium acetate as an additive. Some representative features include external oxidant-free, applicable to terminal alkynes, short reaction time and operational simplicity. The utility of this method is further showcased by the economical synthesis of potent anticancer PARP-1 inhibitors.

34 CFR 491.30 - How may an SEA operate the program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false How may an SEA operate the program? 491.30 Section 491... Conditions Must be Met After an Award? § 491.30 How may an SEA operate the program? An SEA may operate the program directly, award subgrants, or award contracts to eligible recipients. If an SEA awards contracts...

34 CFR 491.30 - How may an SEA operate the program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 3 2012-07-01 2012-07-01 false How may an SEA operate the program? 491.30 Section 491... Conditions Must be Met After an Award? § 491.30 How may an SEA operate the program? An SEA may operate the program directly, award subgrants, or award contracts to eligible recipients. If an SEA awards contracts...

34 CFR 491.30 - How may an SEA operate the program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false How may an SEA operate the program? 491.30 Section 491... Conditions Must be Met After an Award? § 491.30 How may an SEA operate the program? An SEA may operate the program directly, award subgrants, or award contracts to eligible recipients. If an SEA awards contracts...

34 CFR 491.30 - How may an SEA operate the program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 3 2013-07-01 2013-07-01 false How may an SEA operate the program? 491.30 Section 491... Conditions Must be Met After an Award? § 491.30 How may an SEA operate the program? An SEA may operate the program directly, award subgrants, or award contracts to eligible recipients. If an SEA awards contracts...

34 CFR 491.30 - How may an SEA operate the program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 3 2014-07-01 2014-07-01 false How may an SEA operate the program? 491.30 Section 491... Conditions Must be Met After an Award? § 491.30 How may an SEA operate the program? An SEA may operate the program directly, award subgrants, or award contracts to eligible recipients. If an SEA awards contracts...

Effects of Computer Programming on Students' Cognitive Performance: A Quantitative Synthesis.

ERIC Educational Resources Information Center

Liao, Yuen-Kuang Cliff

A meta-analysis was performed to synthesize existing data concerning the effects of computer programing on cognitive outcomes of students. Sixty-five studies were located from three sources, and their quantitative data were transformed into a common scale--Effect Size (ES). The analysis showed that 58 (89%) of the study-weighted ESs were positive…

A Fifty-State Survey of School Finance Policies and Programs: An Overview

ERIC Educational Resources Information Center

Verstegen, Deborah A.; Jordan, Teresa S.

2009-01-01

This overview provides a synthesis of a comprehensive survey of school finance programs in the 50 states conducted in 2006-07. Information was provided by chief state school finance officers or persons with expertise in a state's public school funding-allocation system. Brief descriptions of the major Pre-K-12 funding formulae, district-based…

Report on the Analysis of Some Process-Oriented Curricula. An Annotated Listing. Program Report R101.

ERIC Educational Resources Information Center

Bernstein, Susan; And Others

This report contains 20 summary-descriptions of curriculum programs and materials selected by the Institute for possible inclusion in its synthesis and validation of a K-6 process-promoting curriculum. Each description includes information on the developer and publisher plus a list of references (mostly published descriptions and critiques).…

Serving Special Needs Populations in Postsecondary Occupational Education: A Synthesis of Program Approaches.

ERIC Educational Resources Information Center

Fadale, LaVerna M.; Winter, Gene M.

The Two-Year College Development Center undertook a project to identify two-year college programs in New York State that successfully serve one or more of the special needs populations targeted by the Carl D. Perkins Act. Four special needs populations were targeted for in-depth study: single parents/homemakers, learning disabled, limited English…

Preparing the "New" Biologist of the Future: Student Research at the Interface of Mathematics and Biology

ERIC Educational Resources Information Center

Duncan, Sarah I.; Bishop, Pamela; Lenhart, Suzanne

2010-01-01

We describe a unique Research Experience for Undergraduates and Research Experience for Veterinary students summer program at the National Institute for Mathematical and Biological Synthesis on the campus of the University of Tennessee, Knoxville. The program focused on interdisciplinary research at the interface of biology and mathematics.…

Learning in One-to-One Laptop Environments: A Meta-Analysis and Research Synthesis

ERIC Educational Resources Information Center

Zheng, Binbin; Warschauer, Mark; Lin, Chin-Hsi; Chang, Chi

2016-01-01

Over the past decade, the number of one-to-one laptop programs in schools has steadily increased. Despite the growth of such programs, there is little consensus about whether they contribute to improved educational outcomes. This article reviews 65 journal articles and 31 doctoral dissertations published from January 2001 to May 2015 to examine…

The Battle of RNA Synthesis: Virus versus Host.

PubMed

Harwig, Alex; Landick, Robert; Berkhout, Ben

2017-10-21

Transcription control is the foundation of gene regulation. Whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. Over the course of evolution and adaptation, viruses have found diverse ways to optimally exploit cellular host processes such as transcription to their own benefit. Just as cells are increasingly understood to employ nascent RNAs in transcription regulation, recent discoveries are revealing how viruses use nascent RNAs to benefit their own gene expression. In this review, we first outline the two different transcription programs used by viruses, i.e., transcription (DNA-dependent) and RNA-dependent RNA synthesis. Subsequently, we use the distinct stages (initiation, elongation, termination) to describe the latest insights into nascent RNA-mediated regulation in the context of each relevant stage.

Non-covalent synthesis of supermicelles with complex architectures using spatially confined hydrogen-bonding interactions

PubMed Central

Li, Xiaoyu; Gao, Yang; Boott, Charlotte E.; Winnik, Mitchell A.; Manners, Ian

2015-01-01

Nature uses orthogonal interactions over different length scales to construct structures with hierarchical levels of order and provides an important source of inspiration for the creation of synthetic functional materials. Here, we report the programmed assembly of monodisperse cylindrical block comicelle building blocks with crystalline cores to create supermicelles using spatially confined hydrogen-bonding interactions. We also demonstrate that it is possible to further program the self-assembly of these synthetic building blocks into structures of increased complexity by combining hydrogen-bonding interactions with segment solvophobicity. The overall approach offers an efficient, non-covalent synthesis method for the solution-phase fabrication of a range of complex and potentially functional supermicelle architectures in which the crystallization, hydrogen-bonding and solvophobic interactions are combined in an orthogonal manner. PMID:26337527

Terminal-area STOL operating systems experiments program

NASA Technical Reports Server (NTRS)

Smith, D. W.; Watson, D.; Christensen, J. V.

1973-01-01

Information which will aid in the choice by the U.S. Government and industry of system concepts, design criteria, operating procedures for STOL aircraft and STOL ports, STOL landing guidance systems, air traffic control systems, and airborne avionics and flight control systems. Ames has developed a terminal-area STOL operating systems experiments program which is a part of the joint DOT/NASA effort is discussed. The Ames operating systems experiments program, its objectives, the program approach, the program schedule, typical experiments, the research facilities to be used, and the program status are described.

BETA: Behavioral testability analyzer and its application to high-level test generation and synthesis for testability. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Chen, Chung-Hsing

1992-01-01

In this thesis, a behavioral-level testability analysis approach is presented. This approach is based on analyzing the circuit behavioral description (similar to a C program) to estimate its testability by identifying controllable and observable circuit nodes. This information can be used by a test generator to gain better access to internal circuit nodes and to reduce its search space. The results of the testability analyzer can also be used to select test points or partial scan flip-flops in the early design phase. Based on selection criteria, a novel Synthesis for Testability approach call Test Statement Insertion (TSI) is proposed, which modifies the circuit behavioral description directly. Test Statement Insertion can also be used to modify circuit structural description to improve its testability. As a result, Synthesis for Testability methodology can be combined with an existing behavioral synthesis tool to produce more testable circuits.

Conceptual spacecraft systems design and synthesis

NASA Technical Reports Server (NTRS)

Wright, R. L.; Deryder, D. D.; Ferebee, M. J., Jr.

1984-01-01

An interactive systems design and synthesis is performed on future spacecraft concepts using the Interactive Design and Evaluation of Advanced Systems (IDEAS) computer-aided design and analysis system. The capabilities and advantages of the systems-oriented interactive computer-aided design and analysis system are described. The synthesis of both large antenna and space station concepts, and space station evolutionary growth designs is demonstrated. The IDEAS program provides the user with both an interactive graphics and an interactive computing capability which consists of over 40 multidisciplinary synthesis and analysis modules. Thus, the user can create, analyze, and conduct parametric studies and modify earth-orbiting spacecraft designs (space stations, large antennas or platforms, and technologically advanced spacecraft) at an interactive terminal with relative ease. The IDEAS approach is useful during the conceptual design phase of advanced space missions when a multiplicity of parameters and concepts must be analyzed and evaluated in a cost-effective and timely manner.

Interactive systems design and synthesis of future spacecraft concepts

NASA Technical Reports Server (NTRS)

Wright, R. L.; Deryder, D. D.; Ferebee, M. J., Jr.

1984-01-01

An interactive systems design and synthesis is performed on future spacecraft concepts using the Interactive Design and Evaluation of Advanced spacecraft (IDEAS) computer-aided design and analysis system. The capabilities and advantages of the systems-oriented interactive computer-aided design and analysis system are described. The synthesis of both large antenna and space station concepts, and space station evolutionary growth is demonstrated. The IDEAS program provides the user with both an interactive graphics and an interactive computing capability which consists of over 40 multidisciplinary synthesis and analysis modules. Thus, the user can create, analyze and conduct parametric studies and modify Earth-orbiting spacecraft designs (space stations, large antennas or platforms, and technologically advanced spacecraft) at an interactive terminal with relative ease. The IDEAS approach is useful during the conceptual design phase of advanced space missions when a multiplicity of parameters and concepts must be analyzed and evaluated in a cost-effective and timely manner.

Biomass publications of the forest operations research unit: A synthesis

Treesearch

Dana Mitchell; Renee Ayala; [Compilers

2005-01-01

The Forest Operations Unit of the Southern Research Station has been studying biomass-related topics since 1977. This CD aids the reader by organizing these publications in one easy-to-use CD. This CD is comprised of an executive summary, two bibliographies, individual publications (in PDF format), and a keyword listing. The types of publications included on this CD...

Analysis and Synthesis of Adaptive Neural Elements and Assembles

DTIC Science & Technology

1992-02-17

effects of neuromodulators on electrically activity. Based on the simulations it appears that there are potentially novel mechanisms with which modulatory...and Byrne, J.H. A learning rule based on empirically-derived activity-dependent neuromodulation supports operant conditioning in a small network...dependent neuromodulation can support operant conditioning in a small oscillatory network". 2. Society for Neuroscience Short Course on Neural

Range pattern matching with layer operations and continuous refinements

NASA Astrophysics Data System (ADS)

Tseng, I.-Lun; Lee, Zhao Chuan; Li, Yongfu; Perez, Valerio; Tripathi, Vikas; Ong, Jonathan Yoong Seang

2018-03-01

At advanced and mainstream process nodes (e.g., 7nm, 14nm, 22nm, and 55nm process nodes), lithography hotspots can exist in layouts of integrated circuits even if the layouts pass design rule checking (DRC). Existence of lithography hotspots in a layout can cause manufacturability issues, which can result in yield losses of manufactured integrated circuits. In order to detect lithography hotspots existing in physical layouts, pattern matching (PM) algorithms and commercial PM tools have been developed. However, there are still needs to use DRC tools to perform PM operations. In this paper, we propose a PM synthesis methodology, which uses a continuous refinement technique, for the automatic synthesis of a given lithography hotspot pattern into a DRC deck, which consists of layer operation commands, so that an equivalent PM operation can be performed by executing the synthesized deck with the use of a DRC tool. Note that the proposed methodology can deal with not only exact patterns, but also range patterns. Also, lithography hotspot patterns containing multiple layers can be processed. Experimental results show that the proposed methodology can accurately and efficiently detect lithography hotspots in physical layouts.

Six-flow operations for catalyst development in Fischer-Tropsch synthesis: Bridging the gap between high-throughput experimentation and extensive product evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sartipi, Sina, E-mail: S.Sartipi@tudelft.nl, E-mail: J.Gascon@tudelft.nl; Jansma, Harrie; Bosma, Duco

2013-12-15

Design and operation of a “six-flow fixed-bed microreactor” setup for Fischer-Tropsch synthesis (FTS) is described. The unit consists of feed and mixing, flow division, reaction, separation, and analysis sections. The reactor system is made of five heating blocks with individual temperature controllers, assuring an identical isothermal zone of at least 10 cm along six fixed-bed microreactor inserts (4 mm inner diameter). Such a lab-scale setup allows running six experiments in parallel, under equal feed composition, reaction temperature, and conditions of separation and analysis equipment. It permits separate collection of wax and liquid samples (from each flow line), allowing operation with highmore » productivities of C5+ hydrocarbons. The latter is crucial for a complete understanding of FTS product compositions and will represent an advantage over high-throughput setups with more than ten flows where such instrumental considerations lead to elevated equipment volume, cost, and operation complexity. The identical performance (of the six flows) under similar reaction conditions was assured by testing a same catalyst batch, loaded in all microreactors.« less

Children's application of simultaneous and successive processing in inductive and deductive reasoning problems: Implications for developing scientific reasoning skills

NASA Astrophysics Data System (ADS)

Watters, James J.; English, Lyn D.

The research reported in this article was undertaken to obtain a better understanding of problem solving and scientific reasoning in 10-year-old children. The study involved measuring children's competence at syllogistic reasoning and in solving a series of problems requiring inductive reasoning. Children were also categorized on the basis of levels of simultaneous and successive synthesis. Simultaneous and successive synthesis represent two dimensions of information processing identified by Luria in a program of neuropsychological research. Simultaneous synthesis involves integration of information in a holistic or spatial fashion, whereas successive synthesis involves processing information sequentially with temporal links between stimuli. Analysis of the data generated in the study indicated that syllogistic reasoning and inductive reasoning were significantly correlated with both simultaneous and successive synthesis. However, the strongest correlation was found between simultaneous synthesis and inductive reasoning. These findings provide a basis for understanding the roles of spatial and verbal-logical ability as defined by Luria's neuropsychological theory in scientific problem solving. The results also highlight the need for teachers to provide experiences which are compatible with individual students' information processing styles.Received: 19 October 1993; Revised: 15 December 1994;

76 FR 72029 - Multistate Corridor Operations and Management Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

... in the FHWA Multistate Corridor Operations and Management Program as authorized in 23 U.S.C. 511... Multistate Corridor Operations and Management Program as authorized in 23 U.S.C. 511. This notice clarifies... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Multistate Corridor Operations and...